{
    "biomarker_id": "AN6492-1",
    "biomarker_canonical_id": "AN6492",
    "condition": {
        "recommended_name": {
            "id": "DOID:3571",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3571",
            "name": "liver cancer",
            "description": "A hepatobiliary system cancer that is located_in the liver."
        },
        "synonyms": [
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Ca liver - primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Resectable malignant neoplasm of Liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant hepato-biliary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant tumor of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "non-resectable primary hepatic malignant neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary liver cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "resectable malignant neoplasm of the liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, not specified as primary or secondary",
                "description": ""
            }
        ],
        "id": "DOID:3571"
    },
    "biomarker_component": [
        {
            "biomarker": "increased HSP90AA1 level",
            "assessed_biomarker_entity_id": "P07900-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Heat shock protein HSP 90-alpha",
                "synonyms": [
                    {
                        "synonym": "Lipopolysaccharide-associated protein 2"
                    },
                    {
                        "synonym": "LAP-2"
                    },
                    {
                        "synonym": "LPS-associated protein 2"
                    },
                    {
                        "synonym": "Heat shock 86 kDa"
                    },
                    {
                        "synonym": "HSP 86"
                    },
                    {
                        "synonym": "HSP86"
                    },
                    {
                        "synonym": "Renal carcinoma antigen NY-REN-38"
                    },
                    {
                        "synonym": "Heat shock protein family C member 1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6492-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6492-1"
                },
                {
                    "id": "28939487",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28939487",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Diagnostic performance of plasma Hsp90a was evaluated by the calculated sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). ROC curve showed plasma Hsp90a can discriminating liver cancer with a sensitivity of 92.7% and specificity of 91.3% from non-liver cancer control."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6492-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6492-1"
        },
        {
            "id": "28939487",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28939487",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Diagnostic performance of plasma Hsp90a was evaluated by the calculated sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). ROC curve showed plasma Hsp90a can discriminating liver cancer with a sensitivity of 92.7% and specificity of 91.3% from non-liver cancer control."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6492-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6492-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial.",
            "journal": "EBioMedicine",
            "authors": "Fu Y, Xu X, Huang D, Cui D, Liu L, Liu J, He Z, Liu J, Zheng S, Luo Y",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28939487",
                    "url": "https://glygen.org/publication/PubMed/28939487"
                }
            ],
            "evidence": [
                {
                    "id": "AN6488-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6492-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
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            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 1
                }
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                "journal",
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}