{
    "biomarker_id": "AN6478-1",
    "biomarker_canonical_id": "AN6478",
    "condition": {
        "recommended_name": {
            "id": "DOID:4159",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:4159",
            "name": "skin cancer",
            "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
        },
        "synonyms": [
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "CA - skin cancer",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "malignant neoplasm of skin",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "melanoma and Non-melanoma skin cancer",
                "description": ""
            }
        ],
        "id": "DOID:4159"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased BRMS1 level",
            "assessed_biomarker_entity_id": "Q9HCU9-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Breast cancer metastasis-suppressor 1",
                "synonyms": []
            },
            "specimen": [
                {
                    "name": "skin epidermis",
                    "namespace": "UBERON",
                    "id": "0001003",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001003",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6478-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6478-1"
                },
                {
                    "id": "20935672",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/20935672",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "BRMS1 expression was significantly correlated with disease-specific 5-year survival of melanoma patients (P=0.007, log-rank test). Multivariate Cox regression analysis revealed that BRMS1 staining was an independent prognostic factor for melanoma patients (relative risk=0.51; confidence interval=0.29-0.91; P=0.022). BRMS1 expression was significantly decreased in metastatic melanoma compared with primary melanoma or dysplastic nevi (P=0.021 and 0.001, respectively, chi(2) test). BRMS1 may serve an important prognostic marker and therapeutic target for melanoma patients."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6478-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6478-1"
        },
        {
            "id": "20935672",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/20935672",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "BRMS1 expression was significantly correlated with disease-specific 5-year survival of melanoma patients (P=0.007, log-rank test). Multivariate Cox regression analysis revealed that BRMS1 staining was an independent prognostic factor for melanoma patients (relative risk=0.51; confidence interval=0.29-0.91; P=0.022). BRMS1 expression was significantly decreased in metastatic melanoma compared with primary melanoma or dysplastic nevi (P=0.021 and 0.001, respectively, chi(2) test). BRMS1 may serve an important prognostic marker and therapeutic target for melanoma patients."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6478-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6478-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis.",
            "journal": "Oncogene",
            "authors": "Li J, Cheng Y, Tai D, Martinka M, Welch DR, Li G",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20935672",
                    "url": "https://glygen.org/publication/PubMed/20935672"
                }
            ],
            "evidence": [
                {
                    "id": "AN6477-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6478-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
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        }
    ]
}