{
    "biomarker_id": "AN6477-1",
    "biomarker_canonical_id": "AN6477",
    "condition": {
        "recommended_name": {
            "id": "DOID:4159",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:4159",
            "name": "skin cancer",
            "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
        },
        "synonyms": [
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "CA - skin cancer",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "malignant neoplasm of skin",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "melanoma and Non-melanoma skin cancer",
                "description": ""
            }
        ],
        "id": "DOID:4159"
    },
    "biomarker_component": [
        {
            "biomarker": "increased ALCAM level",
            "assessed_biomarker_entity_id": "Q13740-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "CD166 antigen",
                "synonyms": [
                    {
                        "synonym": "Activated leukocyte cell adhesion molecule"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "skin epidermis",
                    "namespace": "UBERON",
                    "id": "0001003",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001003",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6477-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6477-1"
                },
                {
                    "id": "26134500",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/26134500",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "High ALCAM expression in primary melanoma cells (IRS >/=8) is strongly correlated with unfavorable prognosis as compared with patients with lower ALCAM immunoreactivity in tumor compartment as regards cancer specific overall survival (CSOS) (P = 0.001) and disease free survival (DFS) (P < 0.001). High ALCAM expression in melanoma cells of the primary tumor can be used as a marker of negative outcome and may indicate a more invasive phenotype of cancer cells, which would require a more intensive therapeutic strategy."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6477-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6477-1"
        },
        {
            "id": "26134500",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/26134500",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "High ALCAM expression in primary melanoma cells (IRS >/=8) is strongly correlated with unfavorable prognosis as compared with patients with lower ALCAM immunoreactivity in tumor compartment as regards cancer specific overall survival (CSOS) (P = 0.001) and disease free survival (DFS) (P < 0.001). High ALCAM expression in melanoma cells of the primary tumor can be used as a marker of negative outcome and may indicate a more invasive phenotype of cancer cells, which would require a more intensive therapeutic strategy."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6477-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6477-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Prognostic significance of ALCAM (CD166/MEMD) expression in cutaneous melanoma patients.",
            "journal": "Diagnostic pathology",
            "authors": "Donizy P, Zietek M, Halon A, Leskiewicz M, Kozyra C, Matkowski R",
            "date": "2015",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26134500",
                    "url": "https://glygen.org/publication/PubMed/26134500"
                }
            ],
            "evidence": [
                {
                    "id": "AN6476-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6477-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}