{
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    "biomarker_canonical_id": "AN6469",
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            "resource": "Disease Ontology",
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            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
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                "description": ""
            },
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
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                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
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            },
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "2019-nCoV infection",
                "description": ""
            },
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            },
            {
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                "resource": "MONDO",
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                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
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            },
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                "resource": "MONDO",
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                "description": ""
            },
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                "description": ""
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            {
                "id": "MONDO:0100096",
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            },
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
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                "description": ""
            },
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                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
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            },
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                "resource": "MONDO",
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                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased AOC3 level",
            "assessed_biomarker_entity_id": "Q16853-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
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                "synonyms": [
                    {
                        "synonym": "Semicarbazide-sensitive amine oxidase"
                    },
                    {
                        "synonym": "SSAO"
                    },
                    {
                        "synonym": "Vascular adhesion protein 1"
                    },
                    {
                        "synonym": "VAP-1"
                    },
                    {
                        "synonym": "Copper amine oxidase"
                    },
                    {
                        "synonym": "HPAO"
                    },
                    {
                        "synonym": "Amine oxidase copper-containing 3"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
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                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6469-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6469-1"
        },
        {
            "id": "32582936",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32582936",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6469-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6469-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients.",
            "journal": "The Journal of infectious diseases",
            "authors": "Tong Ming, Jiang Yu, Xia Da, Xiong Ying, Zheng Qing, Chen Fang, Zou Lianhong, Xiao Wen, Zhu Yimin",
            "date": "2020-08-17",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32582936",
                    "url": "https://glygen.org/publication/PubMed/32582936"
                }
            ],
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                    "database": "BiomarkerKB",
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                }
            ]
        }
    ],
    "section_stats": [
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}