{
    "biomarker_id": "AN6456-2",
    "biomarker_canonical_id": "AN6456",
    "condition": {
        "recommended_name": {
            "id": "DOID:11934",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11934",
            "name": "head and neck cancer",
            "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
        },
        "synonyms": [
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck tumours",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head/neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "tumor of head and neck",
                "description": ""
            }
        ],
        "id": "DOID:11934"
    },
    "biomarker_component": [
        {
            "biomarker": "increased C5 level",
            "assessed_biomarker_entity_id": "P01031-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Complement C5",
                "synonyms": [
                    {
                        "synonym": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4"
                    },
                    {
                        "synonym": "Complement C5 alpha' chain"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "4505-4"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6456-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6456-2"
                },
                {
                    "id": "29423024",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29423024",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Higher C5a concentrations correlated with tumor differentiation and OSCC extension state."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6456-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6456-2"
        },
        {
            "id": "29423024",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29423024",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Higher C5a concentrations correlated with tumor differentiation and OSCC extension state."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6456-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6456-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma.",
            "journal": "Oncotarget",
            "authors": "Gallenkamp J, Spanier G, Worle E, Englbrecht M, Kirschfink M, Greslechner R, Braun R, Schafer N, Bauer RJ, Pauly D",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29423024",
                    "url": "https://glygen.org/publication/PubMed/29423024"
                }
            ],
            "evidence": [
                {
                    "id": "AN6456-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6456-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}