{
    "biomarker_id": "AN6449-2",
    "biomarker_canonical_id": "AN6449",
    "condition": {
        "recommended_name": {
            "id": "DOID:1319",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1319",
            "name": "brain cancer",
            "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."
        },
        "synonyms": [
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "BT - Brain tumour",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "adult brain tumor",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "adult malignant brain neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "brain neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "brain neoplasm, adult",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "malignant brain tumour",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "malignant primary brain neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "malignant primary brain tumor",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "malignant tumor of Brain",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "malignant tumor of adult brain",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "neoplasm of brain",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "primary brain neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "primary brain tumor",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "primary malignant neoplasm of brain",
                "description": ""
            },
            {
                "id": "DOID:1319",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1319",
                "name": "tumor of the Brain",
                "description": ""
            }
        ],
        "id": "DOID:1319"
    },
    "biomarker_component": [
        {
            "biomarker": "increased NEFL level",
            "assessed_biomarker_entity_id": "P07196-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Neurofilament light polypeptide",
                "synonyms": [
                    {
                        "synonym": "Neurofilament triplet L protein"
                    },
                    {
                        "synonym": "68 kDa neurofilament protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6449-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6449-2"
                },
                {
                    "id": "33023150",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33023150",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The median NfL level was significantly higher in patients with brain metastases than in patients without (35 versus 16 pg/mL, p = 0.001) and separated patients with an area under the curve of 0.77 (0.66-0.89). An increase in NfL could be measured median 3 months (range: 1-5) before the brain metastasis diagnosis. Further, a high level of NfL at time of brain metastasis diagnosis correlated with an inferior survival (hazard ratio: 2.10 (95% confidence interval: 1.11-3.98))."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6449-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6449-2"
        },
        {
            "id": "33023150",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33023150",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The median NfL level was significantly higher in patients with brain metastases than in patients without (35 versus 16 pg/mL, p = 0.001) and separated patients with an area under the curve of 0.77 (0.66-0.89). An increase in NfL could be measured median 3 months (range: 1-5) before the brain metastasis diagnosis. Further, a high level of NfL at time of brain metastasis diagnosis correlated with an inferior survival (hazard ratio: 2.10 (95% confidence interval: 1.11-3.98))."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6449-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6449-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Neurofilament Light Chain as A Biomarker for Brain Metastases.",
            "journal": "Cancers",
            "authors": "Winther-Larsen A, Hviid CVB, Meldgaard P, Sorensen BS, Sandfeld-Paulsen B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33023150",
                    "url": "https://glygen.org/publication/PubMed/33023150"
                }
            ],
            "evidence": [
                {
                    "id": "AN6449-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6449-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}