{
    "biomarker_id": "AN6446-1",
    "biomarker_canonical_id": "AN6446",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased S100A8 level",
            "assessed_biomarker_entity_id": "P05109-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Protein S100-A8",
                "synonyms": [
                    {
                        "synonym": "Migration inhibitory factor-related protein 8"
                    },
                    {
                        "synonym": "p8"
                    },
                    {
                        "synonym": "MRP-8"
                    },
                    {
                        "synonym": "Cystic fibrosis antigen"
                    },
                    {
                        "synonym": "CFAG"
                    },
                    {
                        "synonym": "Calprotectin L1L subunit"
                    },
                    {
                        "synonym": "Urinary stone protein band A"
                    },
                    {
                        "synonym": "S100 calcium-binding protein A8"
                    },
                    {
                        "synonym": "Calgranulin-A"
                    },
                    {
                        "synonym": "Leukocyte L1 complex light chain"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6446-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6446-1"
                },
                {
                    "id": "25673070",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/25673070",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Serum and mRNA expression levels of S100A8 and S100A9 were found to be upregulated in patients with RCC. The overexpression of S100A8 and S100A9 in cancer cells was also confirmed by immunohistochemistry."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6446-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6446-1"
        },
        {
            "id": "25673070",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/25673070",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Serum and mRNA expression levels of S100A8 and S100A9 were found to be upregulated in patients with RCC. The overexpression of S100A8 and S100A9 in cancer cells was also confirmed by immunohistochemistry."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6446-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6446-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Proteins S100A8 and S100A9 are potential biomarkers for renal cell carcinoma in the early stages: results from a proteomic study integrated with bioinformatics analysis.",
            "journal": "Molecular medicine reports",
            "authors": "Zhang L, Jiang H, Xu G, Wen H, Gu B, Liu J, Mao S, Na R, Jing Y, Ding Q, Zhang Y",
            "date": "2015",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25673070",
                    "url": "https://glygen.org/publication/PubMed/25673070"
                }
            ],
            "evidence": [
                {
                    "id": "AN6445-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6446-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}