{
    "biomarker_id": "AN6442-3",
    "biomarker_canonical_id": "AN6442",
    "condition": {
        "recommended_name": {
            "id": "DOID:9351",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9351",
            "name": "diabetes mellitus",
            "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
        },
        "synonyms": [
            {
                "id": "DOID:9351",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9351",
                "name": "diabetes",
                "description": ""
            }
        ],
        "id": "DOID:9351"
    },
    "biomarker_component": [
        {
            "biomarker": "increased LGALS3 level",
            "assessed_biomarker_entity_id": "P17931-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Galectin-3",
                "synonyms": [
                    {
                        "synonym": "Galactoside-binding protein"
                    },
                    {
                        "synonym": "GALBP"
                    },
                    {
                        "synonym": "Carbohydrate-binding protein 35"
                    },
                    {
                        "synonym": "CBP 35"
                    },
                    {
                        "synonym": "Lectin L-29"
                    },
                    {
                        "synonym": "IgE-binding protein"
                    },
                    {
                        "synonym": "Mac-2 antigen"
                    },
                    {
                        "synonym": "L-31"
                    },
                    {
                        "synonym": "35 kDa lectin"
                    },
                    {
                        "synonym": "Laminin-binding protein"
                    },
                    {
                        "synonym": "Galactose-specific lectin 3"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6442-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6442-3"
                },
                {
                    "id": "25501605",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/25501605",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Gal-3 is a promising biomarker for detecting prediabetes and diabetes. Sixty-one patients had prediabetes (Group 1), 57 had diabetes (Group 2), and 56 had neither diabetes nor prediabetes (Group 3) Gal-3 levels were higher in Group 2 than in Groups 1 and 3. [1,053.9 (358.1) and 744.1 (119.3) vs. 481.7 (175.4) pg/mL; P < 0.001."
                        }
                    ]
                },
                {
                    "id": "31262951",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31262951",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "S100A9 and Galectin-3 are overexpressed in PCDM tumors and mediate insulin resistance. Galectin-3 and S100A9 distinguish PCDM from type 2 diabetes in subjects with new-onset diabetes."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        },
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6442-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6442-3"
        },
        {
            "id": "25501605",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/25501605",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Gal-3 is a promising biomarker for detecting prediabetes and diabetes. Sixty-one patients had prediabetes (Group 1), 57 had diabetes (Group 2), and 56 had neither diabetes nor prediabetes (Group 3) Gal-3 levels were higher in Group 2 than in Groups 1 and 3. [1,053.9 (358.1) and 744.1 (119.3) vs. 481.7 (175.4) pg/mL; P < 0.001."
                }
            ]
        },
        {
            "id": "31262951",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31262951",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "S100A9 and Galectin-3 are overexpressed in PCDM tumors and mediate insulin resistance. Galectin-3 and S100A9 distinguish PCDM from type 2 diabetes in subjects with new-onset diabetes."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6442-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6442-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?",
            "journal": "Journal of endocrinological investigation",
            "authors": "Yilmaz H, Cakmak M, Inan O, Darcin T, Akcay A",
            "date": "2015",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25501605",
                    "url": "https://glygen.org/publication/PubMed/25501605"
                }
            ],
            "evidence": [
                {
                    "id": "AN6442-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6442-3"
                }
            ]
        },
        {
            "title": "Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer-Associated Diabetes.",
            "journal": "Diabetes care",
            "authors": "Liao WC, Huang BS, Yu YH, Yang HH, Chen PR, Huang CC, Huang HY, Wu MS, Chow LP",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31262951",
                    "url": "https://glygen.org/publication/PubMed/31262951"
                }
            ],
            "evidence": [
                {
                    "id": "AN6442-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6442-3"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 2
                }
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                "journal",
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        }
    ]
}