{
    "biomarker_id": "AN6439-2",
    "biomarker_canonical_id": "AN6439",
    "condition": {
        "recommended_name": {
            "id": "DOID:9256",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9256",
            "name": "colorectal cancer",
            "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
        },
        "synonyms": [
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer",
                "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "cancer of colorectum",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "cancer of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "cancer of large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "cancer of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colon cancer, advanced, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colon cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer with chromosomal instability, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectum cancer",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectum neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of colorectum",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of the large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of the large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumour of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumour of large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumour of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumour of the large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "CRC",
                "description": ""
            },
            {
                "id": "MIM:114500",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114500",
                "name": "Colorectal cancer",
                "description": "Colorectal cancer"
            }
        ],
        "id": "DOID:9256"
    },
    "biomarker_component": [
        {
            "biomarker": "increased MMP8 level",
            "assessed_biomarker_entity_id": "P22894-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Neutrophil collagenase",
                "synonyms": [
                    {
                        "synonym": "Matrix metalloproteinase-8"
                    },
                    {
                        "synonym": "MMP-8"
                    },
                    {
                        "synonym": "PMNL collagenase"
                    },
                    {
                        "synonym": "PMNL-CL"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6439-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6439-2"
                },
                {
                    "id": "29808017",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29808017",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The patients with high-serum MMP-8 levels (>100 ng/mL) had poor cancer-specific survival, independent of tumour stage, grade, lymphatic invasion, patient age, BRAF VE1 immunohistochemistry, mismatch repair deficiency, Immunoscore and mGPS. High-serum MMP-8 levels are associated with systemic inflammation and adverse outcome in CRC."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6439-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6439-2"
        },
        {
            "id": "29808017",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29808017",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The patients with high-serum MMP-8 levels (>100 ng/mL) had poor cancer-specific survival, independent of tumour stage, grade, lymphatic invasion, patient age, BRAF VE1 immunohistochemistry, mismatch repair deficiency, Immunoscore and mGPS. High-serum MMP-8 levels are associated with systemic inflammation and adverse outcome in CRC."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6439-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6439-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer.",
            "journal": "British journal of cancer",
            "authors": "Sirnio P, Tuomisto A, Tervahartiala T, Sorsa T, Klintrup K, Karhu T, Herzig KH, Makela J, Karttunen TJ, Salo T, Makinen MJ, Vayrynen JP",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29808017",
                    "url": "https://glygen.org/publication/PubMed/29808017"
                }
            ],
            "evidence": [
                {
                    "id": "AN6439-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6439-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
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        }
    ]
}