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            },
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            },
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            },
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                "description": ""
            },
            {
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                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
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                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "betacoronavirus",
                "description": ""
            },
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                "name": "severe acute respiratory syndrome coronavirus 2",
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            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
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                "resource": "MONDO",
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                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CD40LG level",
            "assessed_biomarker_entity_id": "P29965-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "CD40 ligand",
                "synonyms": [
                    {
                        "synonym": "TNF-related activation protein"
                    },
                    {
                        "synonym": "TRAP"
                    },
                    {
                        "synonym": "T-cell antigen Gp39"
                    },
                    {
                        "synonym": "Tumor necrosis factor ligand superfamily member 5"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6431-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6431-3"
                },
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                    "id": "32619411",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32619411",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "We also show that critical illness is associated with further elevations in VWF, as well as increases in soluble P-selectin and sCD40L when compared with controls. Together, these results provide biochemical evidence that endotheliopathy and platelet activation are ubiquitous in COVID-19-associated coagulopathy and might play key roles in the progression of disease."
                        }
                    ]
                },
                {
                    "id": "32757722",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32757722",
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                    "evidence_list": [
                        {
                            "evidence": "Biomarkers of platelet activity and vascular health are significantly associated with the composite outcome of thrombosis or death in hospitalized patients with COVID-19. P-selectin and sCD40L contribute to thrombosis by supporting platelet-myeloid heteroaggregate formation and thrombi stability by interaction with PSGL-1 and alpha IIb beta3, respectively."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
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            "tags": [
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                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "We also show that critical illness is associated with further elevations in VWF, as well as increases in soluble P-selectin and sCD40L when compared with controls. Together, these results provide biochemical evidence that endotheliopathy and platelet activation are ubiquitous in COVID-19-associated coagulopathy and might play key roles in the progression of disease."
                }
            ]
        },
        {
            "id": "32757722",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32757722",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Biomarkers of platelet activity and vascular health are significantly associated with the composite outcome of thrombosis or death in hospitalized patients with COVID-19. P-selectin and sCD40L contribute to thrombosis by supporting platelet-myeloid heteroaggregate formation and thrombi stability by interaction with PSGL-1 and alpha IIb beta3, respectively."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6431-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6431-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.",
            "journal": "The Lancet. Haematology",
            "authors": "Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32619411",
                    "url": "https://glygen.org/publication/PubMed/32619411"
                }
            ],
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6431-3"
                }
            ]
        },
        {
            "title": "Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease.",
            "journal": "Circulation research",
            "authors": "Barrett TJ, Lee AH, Xia Y, Lin LH, Black M, Cotzia P, Hochman J, Berger JS",
            "date": "2020",
            "reference": [
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6431-3"
                }
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    "section_stats": [
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}