{
    "biomarker_id": "AN6429-2",
    "biomarker_canonical_id": "AN6429",
    "condition": {
        "recommended_name": {
            "id": "DOID:3571",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3571",
            "name": "liver cancer",
            "description": "A hepatobiliary system cancer that is located_in the liver."
        },
        "synonyms": [
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Ca liver - primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Resectable malignant neoplasm of Liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant hepato-biliary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant tumor of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "non-resectable primary hepatic malignant neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary liver cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "resectable malignant neoplasm of the liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, not specified as primary or secondary",
                "description": ""
            }
        ],
        "id": "DOID:3571"
    },
    "biomarker_component": [
        {
            "biomarker": "increased VWF level",
            "assessed_biomarker_entity_id": "P04275-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "von Willebrand factor",
                "synonyms": [
                    {
                        "synonym": "von Willebrand antigen II"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "41867-3"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6429-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6429-2"
                },
                {
                    "id": "30386613",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30386613",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The VWF: Ag levels were higher in patients with severe liver fibrosis stage and/or HCC development than in those without. The area under the curve of VWF: Ag for diagnosis of severe liver fibrosis stage was 0.721. Multivariable analysis showed that only VWF: Ag was a predictive biomarker for HCC development."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6429-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6429-2"
        },
        {
            "id": "30386613",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30386613",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The VWF: Ag levels were higher in patients with severe liver fibrosis stage and/or HCC development than in those without. The area under the curve of VWF: Ag for diagnosis of severe liver fibrosis stage was 0.721. Multivariable analysis showed that only VWF: Ag was a predictive biomarker for HCC development."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6429-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6429-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "von Willebrand factor is a useful biomarker for liver fibrosis and prediction of hepatocellular carcinoma development in patients with hepatitis B and C.",
            "journal": "United European gastroenterology journal",
            "authors": "Takaya H, Kawaratani H, Tsuji Y, Nakanishi K, Saikawa S, Sato S, Sawada Y, Kaji K, Okura Y, Shimozato N, Kitade M, Akahane T, Moriya K, Namisaki T, Mitoro A, Matsumoto M, Fukui H, Yoshiji H",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30386613",
                    "url": "https://glygen.org/publication/PubMed/30386613"
                }
            ],
            "evidence": [
                {
                    "id": "AN6429-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6429-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}