{
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    "biomarker_canonical_id": "AN6429",
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            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
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                "resource": "Disease Ontology",
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                "description": ""
            },
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            },
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                "description": ""
            },
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                "description": ""
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            },
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
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                "resource": "MONDO",
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                "name": "coronavirus disease 2019",
                "description": ""
            },
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                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
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            },
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            },
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                "description": ""
            },
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                "resource": "MONDO",
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                "description": ""
            },
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                "name": "SARS-coronavirus 2",
                "description": ""
            },
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased VWF level",
            "assessed_biomarker_entity_id": "P04275-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "von Willebrand factor",
                "synonyms": [
                    {
                        "synonym": "von Willebrand antigen II"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "41867-3"
                }
            ],
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                    "id": "AN6429-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6429-1"
                },
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                    "id": "32619411",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32619411",
                    "tags": [
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "We also show that critical illness is associated with further elevations in VWF, as well as increases in soluble P-selectin and sCD40L when compared with controls. Together, these results provide biochemical evidence that endotheliopathy and platelet activation are ubiquitous in COVID-19-associated coagulopathy and might play key roles in the progression of disease."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6429-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6429-1"
        },
        {
            "id": "32619411",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32619411",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "We also show that critical illness is associated with further elevations in VWF, as well as increases in soluble P-selectin and sCD40L when compared with controls. Together, these results provide biochemical evidence that endotheliopathy and platelet activation are ubiquitous in COVID-19-associated coagulopathy and might play key roles in the progression of disease."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6429-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6429-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.",
            "journal": "The Lancet. Haematology",
            "authors": "Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32619411",
                    "url": "https://glygen.org/publication/PubMed/32619411"
                }
            ],
            "evidence": [
                {
                    "id": "AN6428-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6429-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
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                }
            ],
            "sort_fields": [
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                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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                }
            ],
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}
