{
    "biomarker_id": "AN6428-1",
    "biomarker_canonical_id": "AN6428",
    "condition": {
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            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
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                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
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                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
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                "name": "2019-nCoV",
                "description": ""
            },
            {
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                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased SIGLEC1 level",
            "assessed_biomarker_entity_id": "Q9BZZ2-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Sialoadhesin",
                "synonyms": [
                    {
                        "synonym": "Sialic acid-binding Ig-like lectin 1"
                    },
                    {
                        "synonym": "Siglec-1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
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                    "database": "BiomarkerKB",
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                },
                {
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                    "database": "PubMed",
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                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "mCD169 could predict SARS-CoV-2 infection at hospital admission during the outbreak. This biomarker could be relevant for triage and rapid therapeutic decision in patients suspected of acute viral infections since mCD169 can be overexpressed in other infections responsible of outbreaks such as influenza or dengue fever."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6428-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6428-1"
        },
        {
            "id": "33206973",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33206973",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "mCD169 could predict SARS-CoV-2 infection at hospital admission during the outbreak. This biomarker could be relevant for triage and rapid therapeutic decision in patients suspected of acute viral infections since mCD169 can be overexpressed in other infections responsible of outbreaks such as influenza or dengue fever."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6428-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6428-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.",
            "journal": "The Journal of infectious diseases",
            "authors": "Bedin AS, Makinson A, Picot MC, Mennechet F, Malergue F, Pisoni A, Nyiramigisha E, Montagnier L, Bollore K, Debiesse S, Morquin D, Veyrenche N, Renault C, Foulongne V, Bret C, Bourdin A, Le Moing V, Van de Perre P, Tuaillon E",
            "date": "2021",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33206973",
                    "url": "https://glygen.org/publication/PubMed/33206973"
                }
            ],
            "evidence": [
                {
                    "id": "AN6423-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6428-1"
                }
            ]
        }
    ],
    "section_stats": [
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            ],
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                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
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                    "count": 1
                }
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}