{
    "biomarker_id": "AN6419-1",
    "biomarker_canonical_id": "AN6419",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased BTK level",
            "assessed_biomarker_entity_id": "Q06187-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Tyrosine-protein kinase BTK",
                "synonyms": [
                    {
                        "synonym": "Agammaglobulinemia tyrosine kinase"
                    },
                    {
                        "synonym": "ATK"
                    },
                    {
                        "synonym": "B-cell progenitor kinase"
                    },
                    {
                        "synonym": "BPK"
                    },
                    {
                        "synonym": "Bruton tyrosine kinase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "75708-8"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6419-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6419-1"
                },
                {
                    "id": "32503877",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32503877",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Analysis revealed significantly elevated BTK activity, as evidenced by autophosphorylation, and increased IL-6 production."
                        }
                    ]
                },
                {
                    "id": "32388230",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32388230",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "In contrast, Bruton tyrosine kinase inhibitors, such as ibrutinib and acalabrutinib, may actually have some protective effect."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6419-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6419-1"
        },
        {
            "id": "32503877",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32503877",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Analysis revealed significantly elevated BTK activity, as evidenced by autophosphorylation, and increased IL-6 production."
                }
            ]
        },
        {
            "id": "32388230",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32388230",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "In contrast, Bruton tyrosine kinase inhibitors, such as ibrutinib and acalabrutinib, may actually have some protective effect."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6419-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6419-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Inhibition of Bruton tyrosine kinase in patients with severe COVID-19.",
            "journal": "Science immunology",
            "authors": "Roschewski M, Lionakis MS, Sharman JP, Roswarski J, Goy A, Monticelli MA, Roshon M, Wrzesinski SH, Desai JV, Zarakas MA, Collen J, Rose K, Hamdy A, Izumi R, Wright GW, Chung KK, Baselga J, Staudt LM, Wilson WH",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32503877",
                    "url": "https://glygen.org/publication/PubMed/32503877"
                }
            ],
            "evidence": [
                {
                    "id": "AN6418-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6419-1"
                }
            ]
        },
        {
            "title": "Covid-19 infection in therapy-naive patients with B-cell chronic lymphocytic leukemia.",
            "journal": "Leukemia research",
            "authors": "Paneesha S, Pratt G, Parry H, Moss P",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32388230",
                    "url": "https://glygen.org/publication/PubMed/32388230"
                }
            ],
            "evidence": [
                {
                    "id": "AN6419-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6419-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
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            ],
            "sort_fields": [
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                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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}