{
    "biomarker_id": "AN6406-1",
    "biomarker_canonical_id": "AN6406",
    "condition": {
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            "id": "DOID:0080600",
            "resource": "Disease Ontology",
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            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
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                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased PF4 level",
            "assessed_biomarker_entity_id": "P02776-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Platelet factor 4",
                "synonyms": [
                    {
                        "synonym": "Oncostatin-A"
                    },
                    {
                        "synonym": "Endothelial cell growth inhibitor"
                    },
                    {
                        "synonym": "Iroplact"
                    },
                    {
                        "synonym": "C-X-C motif chemokine 4"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "6002-0"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6406-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6406-1"
                },
                {
                    "id": "32492406",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32492406",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "In a proteomic investigation of sera in SARS patients, decreasing PF4 was found to be associated with poor prognosis which is in consistent with our findings in COVID-19."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6406-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6406-1"
        },
        {
            "id": "32492406",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32492406",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "In a proteomic investigation of sera in SARS patients, decreasing PF4 was found to be associated with poor prognosis which is in consistent with our findings in COVID-19."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6406-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6406-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.",
            "journal": "Cell",
            "authors": "Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H, Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X, Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Chen H, Guo T",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32492406",
                    "url": "https://glygen.org/publication/PubMed/32492406"
                }
            ],
            "evidence": [
                {
                    "id": "AN6404-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6406-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
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                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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                    "count": 1
                }
            ],
            "sort_fields": [
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}