{ "biomarker_id": "AN6372-7", "biomarker_canonical_id": "AN6372", "condition": { "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "COVID-19", "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2." }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "coronavirus disease 2019", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2 infectious disease", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-CoV-2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "betacoronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-coronavirus", "description": "" } ], "id": "DOID:0080600" }, "biomarker_component": [ { "biomarker": "increased IL8 level", "assessed_biomarker_entity_id": "P10145-1", "assessed_entity_type": "protein", "assessed_biomarker_entity": { "recommended_name": "Interleukin-8", "synonyms": [ { "synonym": "Monocyte-derived neutrophil-activating peptide" }, { "synonym": "MONAP" }, { "synonym": "Lymphocyte-derived neutrophil-activating factor" }, { "synonym": "LYNAP" }, { "synonym": "Neutrophil-activating factor" }, { "synonym": "NAF" }, { "synonym": "Granulocyte chemotactic protein 1" }, { "synonym": "GCP-1" }, { "synonym": "Neutrophil-activating protein 1" }, { "synonym": "NAP-1" }, { "synonym": "Monocyte-derived neutrophil chemotactic factor" }, { "synonym": "MDNCF" }, { "synonym": "GCP/IL-8 protein III" }, { "synonym": "GCP/IL-8 protein VI" }, { "synonym": "IL8/NAP1 form I" }, { "synonym": "Protein 3-10C" }, { "synonym": "IL-8(1-77)" }, { "synonym": "IL8/NAP1 form II" }, { "synonym": "Chemokine (C-X-C motif) ligand 8" }, { "synonym": "MDNCF-c" }, { "synonym": "IL8/NAP1 form VI" }, { "synonym": "(Ser-IL-8)72" }, { "synonym": "MDNCF-b" }, { "synonym": "GCP/IL-8 protein V" }, { "synonym": "IL8/NAP1 form IV" }, { "synonym": "Emoctakin" }, { "synonym": "GCP/IL-8 protein I" }, { "synonym": "IL8/NAP1 form V" }, { "synonym": "GCP/IL-8 protein IV" }, { "synonym": "C-X-C motif chemokine 8" }, { "synonym": "IL8/NAP1 form III" }, { "synonym": "(Ala-IL-8)77" }, { "synonym": "T-cell chemotactic factor" }, { "synonym": "GCP/IL-8 protein II" } ] }, "specimen": [ { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "loinc_code": "33211-4" } ], "evidence_source": [ { "id": "AN6372-7", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7" }, { "id": "33349241", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33349241", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Significant correlations were found about age, IL2R, IL-6, IL-8, IL-10, TNF\u03b1, CRP, ferroprotein, PCT, LC, NC, and EC. PCT (R = -0.650), CRP (R = -0.604), NC (R = -0.585), age (R = -0.564), LC (R = 0.56), IL-6 (R = -0.535), IL2R (R = -0.534) and ferroprotein (R = -0.508) were highly correlated." } ] }, { "id": "32511562", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32511562", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "COVID-19 is associated with high levels of [IL-6, TNF-a, IL-1b, and CXCL8/IL-8]. We found that high serum IL-6, IL-8, and TNF alpha levels at the time of hospitalization were strong and independent predictors of patient survival." } ] }, { "id": "32576222", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32576222", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Levels of VEGF-D, TNF-alpha, SCF, LIF, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, IL-17A, IL-18, IL-1 beta, and IFN-gamma were significantly higher in the critical group than in the severe group (Table 1)." } ] } ] } ], "best_biomarker_role": [ { "role": "monitoring" } ], "evidence_source": [ { "id": "AN6372-7", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7" }, { "id": "32511562", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32511562", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "COVID-19 is associated with high levels of [IL-6, TNF-a, IL-1b, and CXCL8/IL-8]. We found that high serum IL-6, IL-8, and TNF alpha levels at the time of hospitalization were strong and independent predictors of patient survival." } ] }, { "id": "32576222", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32576222", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Levels of VEGF-D, TNF-alpha, SCF, LIF, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, IL-17A, IL-18, IL-1 beta, and IFN-gamma were significantly higher in the critical group than in the severe group (Table 1)." } ] } ], "crossref": [ { "id": "AN6372-7", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7", "categories": [ "Biomarkers" ] } ], "citation": [ { "title": "Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study.", "journal": "BMC infectious diseases", "authors": "Gong Jing, Dong Hui, Xia Qing-Song, Huang Zhao-Yi, Wang Ding-Kun, Zhao Yan, Liu Wen-Hua, Tu Sheng-Hao, Zhang Ming-Min, Wang Qi, Lu Fu-Er", "date": "2020-12-21", "reference": [ { "type": "PubMed", "id": "33349241", "url": "https://glygen.org/publication/PubMed/33349241" } ], "evidence": [ { "id": "AN6353-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7" } ] }, { "title": "An inflammatory cytokine signature helps predict COVID-19 severity and death.", "journal": "medRxiv : the preprint server for health sciences", "authors": "Del Valle DM, Kim-Schulze S, Hsin-Hui H, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz T, Madduri D, Stock A, Marron T, Xie H, Patel MK, van Oekelen O, Rahman A, Kovatch P, Aberg J, Schadt E, Jagannath S, Mazumdar M, Charney A, Firpo-Betancourt A, Mendu DR, Jhang J, Reich D, Sigel K, Cordon-Cardo C, Feldmann M, Parekh S, Merad M, Gnjatic S", "date": "2020", "reference": [ { "type": "PubMed", "id": "32511562", "url": "https://glygen.org/publication/PubMed/32511562" } ], "evidence": [ { "id": "AN6372-7", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7" } ] }, { "title": "VEGF-D: a novel biomarker for detection of COVID-19 progression.", "journal": "Critical care (London, England)", "authors": "Kong Y, Han J, Wu X, Zeng H, Liu J, Zhang H", "date": "2020", "reference": [ { "type": "PubMed", "id": "32576222", "url": "https://glygen.org/publication/PubMed/32576222" } ], "evidence": [ { "id": "AN6372-7", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6372-7" } ] } ], "section_stats": [ { "table_id": "biomarker_component", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "biomarker", "assessed_biomarker_entity_id", "assessed_entity_type", "assessed_biomarker_entity.recommended_name" ] }, { "table_id": "citation", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }