{
    "biomarker_id": "AN6372-4",
    "biomarker_canonical_id": "AN6372",
    "condition": {
        "recommended_name": {
            "id": "DOID:1793",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1793",
            "name": "pancreatic cancer",
            "description": "An endocrine gland cancer located_in the pancreas."
        },
        "synonyms": [
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreas neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic tumor",
                "description": ""
            }
        ],
        "id": "DOID:1793"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL8 level",
            "assessed_biomarker_entity_id": "P10145-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-8",
                "synonyms": [
                    {
                        "synonym": "Monocyte-derived neutrophil-activating peptide"
                    },
                    {
                        "synonym": "MONAP"
                    },
                    {
                        "synonym": "Lymphocyte-derived neutrophil-activating factor"
                    },
                    {
                        "synonym": "LYNAP"
                    },
                    {
                        "synonym": "Neutrophil-activating factor"
                    },
                    {
                        "synonym": "NAF"
                    },
                    {
                        "synonym": "Granulocyte chemotactic protein 1"
                    },
                    {
                        "synonym": "GCP-1"
                    },
                    {
                        "synonym": "Neutrophil-activating protein 1"
                    },
                    {
                        "synonym": "NAP-1"
                    },
                    {
                        "synonym": "Monocyte-derived neutrophil chemotactic factor"
                    },
                    {
                        "synonym": "MDNCF"
                    },
                    {
                        "synonym": "GCP/IL-8 protein III"
                    },
                    {
                        "synonym": "GCP/IL-8 protein VI"
                    },
                    {
                        "synonym": "IL8/NAP1 form I"
                    },
                    {
                        "synonym": "Protein 3-10C"
                    },
                    {
                        "synonym": "IL-8(1-77)"
                    },
                    {
                        "synonym": "IL8/NAP1 form II"
                    },
                    {
                        "synonym": "Chemokine (C-X-C motif) ligand 8"
                    },
                    {
                        "synonym": "MDNCF-c"
                    },
                    {
                        "synonym": "IL8/NAP1 form VI"
                    },
                    {
                        "synonym": "(Ser-IL-8)72"
                    },
                    {
                        "synonym": "MDNCF-b"
                    },
                    {
                        "synonym": "GCP/IL-8 protein V"
                    },
                    {
                        "synonym": "IL8/NAP1 form IV"
                    },
                    {
                        "synonym": "Emoctakin"
                    },
                    {
                        "synonym": "GCP/IL-8 protein I"
                    },
                    {
                        "synonym": "IL8/NAP1 form V"
                    },
                    {
                        "synonym": "GCP/IL-8 protein IV"
                    },
                    {
                        "synonym": "C-X-C motif chemokine 8"
                    },
                    {
                        "synonym": "IL8/NAP1 form III"
                    },
                    {
                        "synonym": "(Ala-IL-8)77"
                    },
                    {
                        "synonym": "T-cell chemotactic factor"
                    },
                    {
                        "synonym": "GCP/IL-8 protein II"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "33211-4"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6372-4",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6372-4"
                },
                {
                    "id": "30304975",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30304975",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer. Patients with high IL-6, IL-8, or IL-10 expression (greater than median expression levels) exhibited a significantly shorter survival time, compared with patients with low expression (less than median expression levels) (p<0.001 for IL-6, p<0.01 for IL-8, and p<0.05 for IL-10) Univariate Cox analysis revealed that a high expression level of either IL-6, IL-8, or IL-10 was associated with poor survival (IL-6: HR = 0.204, 95% CI: 0.107-0.410, p<0.001; IL-8: HR = 0.303, 95% CI: 0.135-0.683, p<0.01; IL-10: HR = 0.336, 95% CI: 0.125-0.900, p<0.05)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6372-4",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6372-4"
        },
        {
            "id": "30304975",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30304975",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer. Patients with high IL-6, IL-8, or IL-10 expression (greater than median expression levels) exhibited a significantly shorter survival time, compared with patients with low expression (less than median expression levels) (p<0.001 for IL-6, p<0.01 for IL-8, and p<0.05 for IL-10) Univariate Cox analysis revealed that a high expression level of either IL-6, IL-8, or IL-10 was associated with poor survival (IL-6: HR = 0.204, 95% CI: 0.107-0.410, p<0.001; IL-8: HR = 0.303, 95% CI: 0.135-0.683, p<0.01; IL-10: HR = 0.336, 95% CI: 0.125-0.900, p<0.05)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6372-4",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6372-4",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer.",
            "journal": "The Journal of international medical research",
            "authors": "Feng L, Qi Q, Wang P, Chen H, Chen Z, Meng Z, Liu L",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30304975",
                    "url": "https://glygen.org/publication/PubMed/30304975"
                }
            ],
            "evidence": [
                {
                    "id": "AN6278-6",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6372-4"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}