{
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    "biomarker_canonical_id": "AN6344",
    "condition": {
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            "id": "DOID:0080600",
            "resource": "Disease Ontology",
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            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
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                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
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                "resource": "Disease Ontology",
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            },
            {
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                "resource": "Disease Ontology",
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                "name": "COVID19",
                "description": ""
            },
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                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
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                "resource": "MONDO",
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                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
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                "name": "2019 novel coronavirus",
                "description": ""
            },
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                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
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                "name": "SARS-CoV-2",
                "description": ""
            },
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                "id": "MONDO:0100096",
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CST3 level",
            "assessed_biomarker_entity_id": "P01034-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Cystatin-C",
                "synonyms": [
                    {
                        "synonym": "Neuroendocrine basic polypeptide"
                    },
                    {
                        "synonym": "Gamma-trace"
                    },
                    {
                        "synonym": "Post-gamma-globulin"
                    },
                    {
                        "synonym": "Cystatin-3"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "33863-2"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6344-1",
                    "database": "BiomarkerKB",
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                },
                {
                    "id": "32505227",
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                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Other consistently reported markers in non-survivors are increased procalcitonin (PCT) and IL-6 levels, as well as increased serum urea, creatinine, cystatin C, direct bilirubin, and cholinesterase."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6344-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6344-1"
        },
        {
            "id": "32505227",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32505227",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Other consistently reported markers in non-survivors are increased procalcitonin (PCT) and IL-6 levels, as well as increased serum urea, creatinine, cystatin C, direct bilirubin, and cholinesterase."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6344-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6344-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Immunology of COVID-19: Current State of the Science.",
            "journal": "Immunity",
            "authors": "Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salome B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gumus ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32505227",
                    "url": "https://glygen.org/publication/PubMed/32505227"
                }
            ],
            "evidence": [
                {
                    "id": "AN6747-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6344-1"
                }
            ]
        }
    ],
    "section_stats": [
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            ],
            "sort_fields": [
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                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
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}