{
    "biomarker_id": "AN6337-2",
    "biomarker_canonical_id": "AN6337",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL10 level",
            "assessed_biomarker_entity_id": "P22301-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-10",
                "synonyms": [
                    {
                        "synonym": "Cytokine synthesis inhibitory factor"
                    },
                    {
                        "synonym": "CSIF"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "26848-2"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6337-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6337-2"
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNF alpha were higher in ICU patients than non-ICU patients. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNF alpha."
                        }
                    ]
                },
                {
                    "id": "32222466",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32222466",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IL-2, IL-7, IL-10, G-CSF, IP10, MCP1, MIP1A, TNF alpha were higher in severe patients."
                        }
                    ]
                },
                {
                    "id": "33349241",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33349241",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Significant correlations were found about age, IL2R, IL-6, IL-8, IL-10, TNF\u03b1, CRP, ferroprotein, PCT, LC, NC, and EC. PCT (R = -0.650), CRP (R = -0.604), NC (R = -0.585), age (R = -0.564), LC (R = 0.56), IL-6 (R = -0.535), IL2R (R = -0.534) and ferroprotein (R = -0.508) were highly correlated."
                        }
                    ]
                },
                {
                    "id": "32576222",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32576222",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Levels of VEGF-D, TNF-alpha, SCF, LIF, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, IL-17A, IL-18, IL-1 beta, and IFN-gamma were significantly higher in the critical group than in the severe group (Table 1)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6337-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6337-2"
        },
        {
            "id": "31986264",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31986264",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNF alpha were higher in ICU patients than non-ICU patients. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNF alpha."
                }
            ]
        },
        {
            "id": "32222466",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32222466",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IL-2, IL-7, IL-10, G-CSF, IP10, MCP1, MIP1A, TNF alpha were higher in severe patients."
                }
            ]
        },
        {
            "id": "33349241",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/33349241",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Significant correlations were found about age, IL2R, IL-6, IL-8, IL-10, TNF\u03b1, CRP, ferroprotein, PCT, LC, NC, and EC. PCT (R = -0.650), CRP (R = -0.604), NC (R = -0.585), age (R = -0.564), LC (R = 0.56), IL-6 (R = -0.535), IL2R (R = -0.534) and ferroprotein (R = -0.508) were highly correlated."
                }
            ]
        },
        {
            "id": "32576222",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32576222",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Levels of VEGF-D, TNF-alpha, SCF, LIF, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, IL-17A, IL-18, IL-1 beta, and IFN-gamma were significantly higher in the critical group than in the severe group (Table 1)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6337-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6337-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
            "evidence": [
                {
                    "id": "AN6337-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6337-2"
                }
            ]
        },
        {
            "title": "The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.",
            "journal": "Clinical immunology (Orlando, Fla.)",
            "authors": "Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, Zeng X, Zhang S",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32222466",
                    "url": "https://glygen.org/publication/PubMed/32222466"
                }
            ],
            "evidence": [
                {
                    "id": "AN6337-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6337-2"
                }
            ]
        },
        {
            "title": "Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study.",
            "journal": "BMC infectious diseases",
            "authors": "Gong Jing, Dong Hui, Xia Qing-Song, Huang Zhao-Yi, Wang Ding-Kun, Zhao Yan, Liu Wen-Hua, Tu Sheng-Hao, Zhang Ming-Min, Wang Qi, Lu Fu-Er",
            "date": "2020-12-21",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33349241",
                    "url": "https://glygen.org/publication/PubMed/33349241"
                }
            ],
            "evidence": [
                {
                    "id": "AN6337-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6337-2"
                }
            ]
        },
        {
            "title": "VEGF-D: a novel biomarker for detection of COVID-19 progression.",
            "journal": "Critical care (London, England)",
            "authors": "Kong Y, Han J, Wu X, Zeng H, Liu J, Zhang H",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32576222",
                    "url": "https://glygen.org/publication/PubMed/32576222"
                }
            ],
            "evidence": [
                {
                    "id": "AN6337-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6337-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
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                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
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        },
        {
            "table_id": "citation",
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}