{
    "biomarker_id": "AN6330-2",
    "biomarker_canonical_id": "AN6330",
    "condition": {
        "recommended_name": {
            "id": "DOID:9351",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9351",
            "name": "diabetes mellitus",
            "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."
        },
        "synonyms": [
            {
                "id": "DOID:9351",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9351",
                "name": "diabetes",
                "description": ""
            }
        ],
        "id": "DOID:9351"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IFNG level",
            "assessed_biomarker_entity_id": "P01579-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interferon gamma",
                "synonyms": [
                    {
                        "synonym": "Immune interferon"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "12729-0"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6330-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6330-2"
                },
                {
                    "id": "15296648",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15296648",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IFN gamma level in patients from group 1 (T2DM) was 3.13 \u00ac\u00b1 0.92 pg/ml, group 2 (CC) 2.73 \u00ac\u00b1 0.91 pg/ ml, group 3 (T2DM and CC) 2.46 \u00ac\u00b1 0.98 pg/ml and group 4 (control) 5.02 \u00ac\u00b1 1.43 pg/ml; p < 0.05. There was no statistically significant difference in the concentration of IFN gamma in patients with T2DM and CC compared to other subjects. However, it has been demonstrated that level of IFN gamma in the control group and the group of patients with T2DM without CC was higher than in the other two groups."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6330-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6330-2"
        },
        {
            "id": "15296648",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15296648",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IFN gamma level in patients from group 1 (T2DM) was 3.13 \u00ac\u00b1 0.92 pg/ml, group 2 (CC) 2.73 \u00ac\u00b1 0.91 pg/ ml, group 3 (T2DM and CC) 2.46 \u00ac\u00b1 0.98 pg/ml and group 4 (control) 5.02 \u00ac\u00b1 1.43 pg/ml; p < 0.05. There was no statistically significant difference in the concentration of IFN gamma in patients with T2DM and CC compared to other subjects. However, it has been demonstrated that level of IFN gamma in the control group and the group of patients with T2DM without CC was higher than in the other two groups."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6330-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6330-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Intracellular IFN-gamma production and IL-12 serum levels in latent autoimmune diabetes of adults (LADA) and in type 2 diabetes.",
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research",
            "authors": "Tsiavou A, Degiannis D, Hatziagelaki E, Koniavitou K, Raptis SA",
            "date": "2004",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15296648",
                    "url": "https://glygen.org/publication/PubMed/15296648"
                }
            ],
            "evidence": [
                {
                    "id": "AN6330-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6330-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}