{
    "biomarker_id": "AN6314-3",
    "biomarker_canonical_id": "AN6314",
    "condition": {
        "recommended_name": {
            "id": "DOID:1612",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1612",
            "name": "breast cancer",
            "description": "An organ system cancer that originates in the mammary gland."
        },
        "synonyms": [
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "breast tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant neoplasm of breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant tumor of the breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast carcinoma",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
    "biomarker_component": [
        {
            "biomarker": "increased WFDC2 level",
            "assessed_biomarker_entity_id": "Q14508-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "WAP four-disulfide core domain protein 2",
                "synonyms": [
                    {
                        "synonym": "Major epididymis-specific protein E4"
                    },
                    {
                        "synonym": "Putative protease inhibitor WAP5"
                    },
                    {
                        "synonym": "Epididymal secretory protein E4"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "55180-4"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6314-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-3"
                },
                {
                    "id": "27446579",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/27446579",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "There was a significant difference in the median serum levels of HE4 in breast cancer patients, ovarian cancer patients and healthy volunteers (14.63, 16.47 and 11.52 pmol/l, respectively; P=0.013). No significant differences between the breast cancer and ovarian cancer patient groups was observed, the median serum levels of HE4 in these groups were significantly higher than those in the healthy volunteer group (P=0.006 and P=0.017, respectively).The cutoff value for the prediction of breast cancer was determined at >13.24 pmol/l for HE4 with a sensitivity of 61.11%, specificity of 68.75%, positive predictive value of 81.48%, negative predictive value of 44.0% and accuracy of 63.46% [AUC, 0.740 (95% CI, 0.604\u201a\u00c4\u00ec0.875), P=0.006] A significant elevation of serum HE4 levels in patients with breast cancer compared with that in healthy controls was identified. HE4 may serve as a novel biomarker for the diagnosis of breast cancer."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6314-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6314-3"
        },
        {
            "id": "27446579",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/27446579",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "There was a significant difference in the median serum levels of HE4 in breast cancer patients, ovarian cancer patients and healthy volunteers (14.63, 16.47 and 11.52 pmol/l, respectively; P=0.013). No significant differences between the breast cancer and ovarian cancer patient groups was observed, the median serum levels of HE4 in these groups were significantly higher than those in the healthy volunteer group (P=0.006 and P=0.017, respectively).The cutoff value for the prediction of breast cancer was determined at >13.24 pmol/l for HE4 with a sensitivity of 61.11%, specificity of 68.75%, positive predictive value of 81.48%, negative predictive value of 44.0% and accuracy of 63.46% [AUC, 0.740 (95% CI, 0.604\u201a\u00c4\u00ec0.875), P=0.006] A significant elevation of serum HE4 levels in patients with breast cancer compared with that in healthy controls was identified. HE4 may serve as a novel biomarker for the diagnosis of breast cancer."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6314-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6314-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "A new marker for breast cancer diagnosis, human epididymis protein 4: A preliminary study.",
            "journal": "Molecular and clinical oncology",
            "authors": "Gunduz UR, Gunaldi M, Isiksacan N, Gunduz S, Okuturlar Y, Kocoglu H",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27446579",
                    "url": "https://glygen.org/publication/PubMed/27446579"
                }
            ],
            "evidence": [
                {
                    "id": "AN6314-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-3"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}