{
    "biomarker_id": "AN6314-1",
    "biomarker_canonical_id": "AN6314",
    "condition": {
        "recommended_name": {
            "id": "DOID:2394",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:2394",
            "name": "ovarian cancer",
            "description": "A female reproductive organ cancer that is located_in the ovary."
        },
        "synonyms": [
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant Ovarian tumor",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "primary ovarian cancer",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "tumor of the Ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased WFDC2 level",
            "assessed_biomarker_entity_id": "Q14508-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "WAP four-disulfide core domain protein 2",
                "synonyms": [
                    {
                        "synonym": "Major epididymis-specific protein E4"
                    },
                    {
                        "synonym": "Putative protease inhibitor WAP5"
                    },
                    {
                        "synonym": "Epididymal secretory protein E4"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "55180-4"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6314-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-1"
                },
                {
                    "id": "21633297",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21633297",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Early diagnosis is the most important determinant of early survival for ovarian cancer, and increased levels of HE4, in combination with CA125, is used as a diagnostic marker for ovarian cancer. HE4 levels were found to be significantly higher in individuals with ovarian cancer. Combining both HE4 and CA125 yielded specificity for ovarian cancer of 100%."
                        }
                    ]
                },
                {
                    "id": "19732003",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/19732003",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Preliminary data show that HE4 may have more potential than cancer antigen 125 in discriminating benign from cancerous ovarian masses, and has the strongest correlation with endometrial cancer of all markers tested to date. Utilizing risk stratification, a panel of biomarkers including HE4 may ultimately be useful for detecting ovarian and endometrial cancer at an early stage in patients at high risk."
                        }
                    ]
                },
                {
                    "id": "21683503",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21683503",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Our results demonstrated that an elevated serum HE4 level was related to the advanced stage of epithelial ovarian cancer. An elevated serum level of HE4 is a poor prognostic factor for PFS in patients with epithelial ovarian cancer who were treated with debulking surgery and adjuvant taxane and platinum-based chemotherapy."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6314-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6314-1"
        },
        {
            "id": "21633297",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21633297",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Early diagnosis is the most important determinant of early survival for ovarian cancer, and increased levels of HE4, in combination with CA125, is used as a diagnostic marker for ovarian cancer. HE4 levels were found to be significantly higher in individuals with ovarian cancer. Combining both HE4 and CA125 yielded specificity for ovarian cancer of 100%."
                }
            ]
        },
        {
            "id": "19732003",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/19732003",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Preliminary data show that HE4 may have more potential than cancer antigen 125 in discriminating benign from cancerous ovarian masses, and has the strongest correlation with endometrial cancer of all markers tested to date. Utilizing risk stratification, a panel of biomarkers including HE4 may ultimately be useful for detecting ovarian and endometrial cancer at an early stage in patients at high risk."
                }
            ]
        },
        {
            "id": "21683503",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21683503",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Our results demonstrated that an elevated serum HE4 level was related to the advanced stage of epithelial ovarian cancer. An elevated serum level of HE4 is a poor prognostic factor for PFS in patients with epithelial ovarian cancer who were treated with debulking surgery and adjuvant taxane and platinum-based chemotherapy."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6314-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6314-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Human epididymis protein 4 (HE4) as a serum tumor biomarker in patients with ovarian carcinoma.",
            "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
            "authors": "Chang X, Ye X, Dong L, Cheng H, Cheng Y, Zhu L, Liao Q, Zhao Y, Tian L, Fu T, Chen J, Cui H",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21633297",
                    "url": "https://glygen.org/publication/PubMed/21633297"
                }
            ],
            "evidence": [
                {
                    "id": "AN6312-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-1"
                }
            ]
        },
        {
            "title": "HE4 as a biomarker for ovarian and endometrial cancer management.",
            "journal": "Expert review of molecular diagnostics",
            "authors": "Li J, Dowdy S, Tipton T, Podratz K, Lu WG, Xie X, Jiang SW",
            "date": "2009",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19732003",
                    "url": "https://glygen.org/publication/PubMed/19732003"
                }
            ],
            "evidence": [
                {
                    "id": "AN6314-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-1"
                }
            ]
        },
        {
            "title": "Prognostic significance of human epididymis protein 4 in epithelial ovarian cancer.",
            "journal": "European journal of obstetrics, gynecology, and reproductive biology",
            "authors": "Paek J, Lee SH, Yim GW, Lee M, Kim YJ, Nam EJ, Kim SW, Kim YT",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21683503",
                    "url": "https://glygen.org/publication/PubMed/21683503"
                }
            ],
            "evidence": [
                {
                    "id": "AN6314-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6314-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 3
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}