{
    "biomarker_id": "AN6310-1",
    "biomarker_canonical_id": "AN6310",
    "condition": {
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            },
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                "description": ""
            },
            {
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                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
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            },
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            },
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            },
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            },
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            },
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                "name": "2019-nCoV",
                "description": ""
            },
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                "id": "MONDO:0100096",
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                "description": ""
            },
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                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
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            },
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                "id": "MONDO:0100096",
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                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "-CoVs",
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            },
            {
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                "resource": "MONDO",
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                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased TMPRSS2 level",
            "assessed_biomarker_entity_id": "O15393-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Transmembrane protease serine 2",
                "synonyms": [
                    {
                        "synonym": "Serine protease 10"
                    }
                ]
            },
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                {
                    "name": "blood",
                    "namespace": "UBERON",
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                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
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                },
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "The role of transmembrane protease serine 2 (TMPRSS2) as a contributing factor to the more severe outcomes noted for COVID-19. Validated TMPRSS2 SNPs that are confirmed to be predictive biomarkers can be incorporated in the CDCs current list of clinical biomarkers for disease severity as discussed above."
                        }
                    ]
                },
                {
                    "id": "32660890",
                    "database": "PubMed",
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                    "tags": [
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                    ],
                    "evidence_list": [
                        {
                            "evidence": "TMPRSS2 expression is regulated in part by androgens and is a known biomarker of prostate cancer severity when fused with ERG. It is known that TMPRSS2 expression is upregulated by androgens in prostate cancer cell lines and in vivo. The authors analyzed data from 4,532 men who tested positive for SARS-CoV-2. Of these patients, 430 (9.5%) had cancer and 118 (2.6%) had prostate cancer (28% of all cancers). Consistent with other publications, men with cancer have worse disease presentations than men without cancer, even when stratified for age. In the 5,273 prostate cancer patients on androgen deprivation therapy (ADT); only four of these patients were positive for SARS-CoV-2. The authors stated that men positive for SARS-CoV-2 and on ADT not only had improved outcomes over other men with prostate cancer positive for SARS-CoV-2, but that ADT may have reduced the chance of infection. They concluded that ADT had a protective effect in men positive for SARS-CoV-2 infection. ADT therapy provides the first evidence that reducing androgens or their effect on tissues may have a beneficial impact on outcomes in men infected with SARS-CoV-2."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6310-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6310-1"
        },
        {
            "id": "32437018",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32437018",
            "tags": [
                "best_biomarker_role",
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            ],
            "evidence_list": [
                {
                    "evidence": "The role of transmembrane protease serine 2 (TMPRSS2) as a contributing factor to the more severe outcomes noted for COVID-19. Validated TMPRSS2 SNPs that are confirmed to be predictive biomarkers can be incorporated in the CDCs current list of clinical biomarkers for disease severity as discussed above."
                }
            ]
        },
        {
            "id": "32660890",
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            "url": "https://glygen.org/publication/PubMed/32660890",
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                "best_biomarker_role",
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            ],
            "evidence_list": [
                {
                    "evidence": "TMPRSS2 expression is regulated in part by androgens and is a known biomarker of prostate cancer severity when fused with ERG. It is known that TMPRSS2 expression is upregulated by androgens in prostate cancer cell lines and in vivo. The authors analyzed data from 4,532 men who tested positive for SARS-CoV-2. Of these patients, 430 (9.5%) had cancer and 118 (2.6%) had prostate cancer (28% of all cancers). Consistent with other publications, men with cancer have worse disease presentations than men without cancer, even when stratified for age. In the 5,273 prostate cancer patients on androgen deprivation therapy (ADT); only four of these patients were positive for SARS-CoV-2. The authors stated that men positive for SARS-CoV-2 and on ADT not only had improved outcomes over other men with prostate cancer positive for SARS-CoV-2, but that ADT may have reduced the chance of infection. They concluded that ADT had a protective effect in men positive for SARS-CoV-2 infection. ADT therapy provides the first evidence that reducing androgens or their effect on tissues may have a beneficial impact on outcomes in men infected with SARS-CoV-2."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6310-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6310-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "TMPRSS2: Potential Biomarker for COVID-19 Outcomes.",
            "journal": "Journal of clinical pharmacology",
            "authors": "Strope JD, PharmD CHC, Figg WD",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32437018",
                    "url": "https://glygen.org/publication/PubMed/32437018"
                }
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                    "id": "AN6309-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6310-1"
                }
            ]
        },
        {
            "title": "Are sex discordant outcomes in COVID-19 related to sex hormones?",
            "journal": "Seminars in oncology",
            "authors": "Strope JD, Chau CH, Figg WD",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32660890",
                    "url": "https://glygen.org/publication/PubMed/32660890"
                }
            ],
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6310-1"
                }
            ]
        }
    ],
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