{
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    "biomarker_canonical_id": "AN6296",
    "condition": {
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            "id": "DOID:0080600",
            "resource": "Disease Ontology",
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            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
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                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CXCL10 level",
            "assessed_biomarker_entity_id": "P02778-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "C-X-C motif chemokine 10",
                "synonyms": [
                    {
                        "synonym": "10 kDa interferon gamma-induced protein"
                    },
                    {
                        "synonym": "Gamma-IP10"
                    },
                    {
                        "synonym": "IP-10"
                    },
                    {
                        "synonym": "Small-inducible cytokine B10"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6296-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6296-1"
                },
                {
                    "id": "32360286",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32360286",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IFN-gamma-induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19.;|IP-10 and MCP-3 were highly associated with disease severity and could be used as excellent predictors of COVID-19 progression."
                        }
                    ]
                },
                {
                    "id": "31986264",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31986264",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "We noted that patients infected with 2019-nCoV also had high amounts of IL1B, IFN gamma, IP10, and MCP1, probably leading to activated T-helper-1 (Th1) cell responses. Moreover, patients requiring ICU admission had higher concentrations of GCSF, IP10, MCP1, MIP1A, and TNF alpha than did those not requiring ICU admission, suggesting that the cytokine storm was associated with disease severity."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6296-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6296-1"
        },
        {
            "id": "32360286",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32360286",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IFN-gamma-induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19.;|IP-10 and MCP-3 were highly associated with disease severity and could be used as excellent predictors of COVID-19 progression."
                }
            ]
        },
        {
            "id": "31986264",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31986264",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "We noted that patients infected with 2019-nCoV also had high amounts of IL1B, IFN gamma, IP10, and MCP1, probably leading to activated T-helper-1 (Th1) cell responses. Moreover, patients requiring ICU admission had higher concentrations of GCSF, IP10, MCP1, MIP1A, and TNF alpha than did those not requiring ICU admission, suggesting that the cytokine storm was associated with disease severity."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6296-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6296-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19.",
            "journal": "The Journal of allergy and clinical immunology",
            "authors": "Yang Y, Shen C, Li J, Yuan J, Wei J, Huang F, Wang F, Li G, Li Y, Xing L, Peng L, Yang M, Cao M, Zheng H, Wu W, Zou R, Li D, Xu Z, Wang H, Zhang M, Zhang Z, Gao GF, Jiang C, Liu L, Liu Y",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32360286",
                    "url": "https://glygen.org/publication/PubMed/32360286"
                }
            ],
            "evidence": [
                {
                    "id": "AN6294-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6296-1"
                }
            ]
        },
        {
            "title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.",
            "journal": "Lancet (London, England)",
            "authors": "Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31986264",
                    "url": "https://glygen.org/publication/PubMed/31986264"
                }
            ],
            "evidence": [
                {
                    "id": "AN6296-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6296-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
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        },
        {
            "table_id": "citation",
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}