{
    "biomarker_id": "AN6295-1",
    "biomarker_canonical_id": "AN6295",
    "condition": {
        "recommended_name": {
            "id": "DOID:1793",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1793",
            "name": "pancreatic cancer",
            "description": "An endocrine gland cancer located_in the pancreas."
        },
        "synonyms": [
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreas neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic tumor",
                "description": ""
            }
        ],
        "id": "DOID:1793"
    },
    "biomarker_component": [
        {
            "biomarker": "increased SAA1 level",
            "assessed_biomarker_entity_id": "P0DJI8-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Serum amyloid A-1 protein",
                "synonyms": [
                    {
                        "synonym": "Amyloid fibril protein AA"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "48498-0"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6295-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6295-1"
                },
                {
                    "id": "16211233",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/16211233",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The level of SAA in plasma of pancreatic cancer patients correlated with clinical stage and was significantly higher than in normal volunteers."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6295-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6295-1"
        },
        {
            "id": "16211233",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/16211233",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The level of SAA in plasma of pancreatic cancer patients correlated with clinical stage and was significantly higher than in normal volunteers."
                }
            ]
        },
        {
            "id": "19536090",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/19536090",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "SAA gene expression levels were significantly higher in USPC when compared with NEC (mean copy number by RT-PCR=162 vs 2.21; P=0.0002). IHC revealed diffuse cytoplasmic SAA protein staining in USPC tissues. High intracellular levels of SAA were identified in primary USPC cell lines evaluated by flow cytometry and SAA was found to be actively secreted in vitro."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6295-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6295-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.",
            "journal": "International journal of oncology",
            "authors": "Yokoi K, Shih LC, Kobayashi R, Koomen J, Hawke D, Li D, Hamilton SR, Abbruzzese JL, Coombes KR, Fidler IJ",
            "date": "2005",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16211233",
                    "url": "https://glygen.org/publication/PubMed/16211233"
                }
            ],
            "evidence": [
                {
                    "id": "AN6293-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6295-1"
                }
            ]
        },
        {
            "title": "Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer.",
            "journal": "British journal of cancer",
            "authors": "Cocco E, Bellone S, El-Sahwi K, Cargnelutti M, Casagrande F, Buza N, Tavassoli FA, Siegel ER, Visintin I, Ratner E, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD",
            "date": "2009",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19536090",
                    "url": "https://glygen.org/publication/PubMed/19536090"
                }
            ],
            "evidence": [
                {
                    "id": "AN6295-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6295-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
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                "journal",
                "authors",
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}