{
    "biomarker_id": "AN6293-1",
    "biomarker_canonical_id": "AN6293",
    "condition": {
        "recommended_name": {
            "id": "DOID:3571",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3571",
            "name": "liver cancer",
            "description": "A hepatobiliary system cancer that is located_in the liver."
        },
        "synonyms": [
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Ca liver - primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Resectable malignant neoplasm of Liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant hepato-biliary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant tumor of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "non-resectable primary hepatic malignant neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary liver cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "resectable malignant neoplasm of the liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, not specified as primary or secondary",
                "description": ""
            }
        ],
        "id": "DOID:3571"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased CYP3A4 level",
            "assessed_biomarker_entity_id": "P08684-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Cytochrome P450 3A4",
                "synonyms": [
                    {
                        "synonym": "Nifedipine oxidase"
                    },
                    {
                        "synonym": "Cytochrome P450-PCN1"
                    },
                    {
                        "synonym": "CYPIIIA4"
                    },
                    {
                        "synonym": "Cytochrome P450 HLp"
                    },
                    {
                        "synonym": "Cytochrome P450 3A3"
                    },
                    {
                        "synonym": "Albendazole sulfoxidase"
                    },
                    {
                        "synonym": "Cytochrome P450 NF-25"
                    },
                    {
                        "synonym": "CYPIIIA3"
                    },
                    {
                        "synonym": "1,8-cineole 2-exo-monooxygenase"
                    },
                    {
                        "synonym": "1.14.14.56"
                    },
                    {
                        "synonym": "Quinine 3-monooxygenase"
                    },
                    {
                        "synonym": "1.14.14.55"
                    },
                    {
                        "synonym": "Albendazole monooxygenase (sulfoxide-forming)"
                    },
                    {
                        "synonym": "1.14.14.73"
                    },
                    {
                        "synonym": "1,4-cineole 2-exo-monooxygenase"
                    },
                    {
                        "synonym": "Cholesterol 25-hydroxylase"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6293-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6293-1"
                },
                {
                    "id": "29109094",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29109094",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "CYP3A4 was identified as a novel tumor suppressor gene related to a poor prognosis in HCC."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6293-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6293-1"
        },
        {
            "id": "29109094",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29109094",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "CYP3A4 was identified as a novel tumor suppressor gene related to a poor prognosis in HCC."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6293-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6293-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma.",
            "journal": "Cancer genomics & proteomics",
            "authors": "Ashida R, Okamura Y, Ohshima K, Kakuda Y, Uesaka K, Sugiura T, Ito T, Yamamoto Y, Sugino T, Urakami K, Kusuhara M, Yamaguchi K",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29109094",
                    "url": "https://glygen.org/publication/PubMed/29109094"
                }
            ],
            "evidence": [
                {
                    "id": "AN6292-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6293-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "journal",
                "authors",
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        }
    ]
}