{ "biomarker_id": "AN6290-5", "biomarker_canonical_id": "AN6290", "condition": { "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "COVID-19", "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2." }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "coronavirus disease 2019", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2 infectious disease", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-CoV-2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "betacoronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-coronavirus", "description": "" } ], "id": "DOID:0080600" }, "biomarker_component": [ { "biomarker": "increased CRP level", "assessed_biomarker_entity_id": "P02741-1", "assessed_entity_type": "protein", "assessed_biomarker_entity": { "recommended_name": "C-reactive protein", "synonyms": [] }, "specimen": [ { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "loinc_code": "71426-1" } ], "evidence_source": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" }, { "id": "32425269", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32425269", "tags": [ "assessed_biomarker_entity", " assessed_biomarker_entity_id", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome." } ] }, { "id": "32240105", "database": "PubMed", "url": "", "tags": [ "assessed_biomarker_entity", " assessed_biomarker_entity_id", " biomarker" ], "evidence_list": [ { "evidence": "Elevated CRP levels are linked with severe inflammatory response in COVID-19 patients and predict poor clinical outcomes." } ] }, { "id": "32277967", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32277967", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones.;|SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones." } ] }, { "id": "32677844", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32677844", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant." } ] }, { "id": "32347972", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32347972", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e213.1; severe: 35.0\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e239.2; critical: 66.1\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e267.3; in mg/L; P\u201a\u00c4\u00e2=\u201a\u00c4\u00e2.002)." } ] }, { "id": "33349241", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33349241", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented." } ] }, { "id": "32161940", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32161940", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19." } ] }, { "id": "32566572", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32566572", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission." } ] }, { "id": "32243911", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32243911", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring.;|Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring." } ] }, { "id": "32475810", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32475810", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts.;|CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity." } ] }, { "id": "32296824", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32296824", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19." } ] }, { "id": "32281668", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32281668", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19.;|CRP which was associated with disease development, predicted early severe COVID-19." } ] }, { "id": "32368728", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32368728", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms." } ] }, { "id": "32511972", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32511972", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality." } ] }, { "id": "32344321", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32344321", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19." } ] }, { "id": "32615866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32615866", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19." } ] }, { "id": "32471703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32471703", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room." } ] }, { "id": "32414383", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32414383", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration." } ] }, { "id": "32048163", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32048163", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury." } ] }, { "id": "32369209", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32369209", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "Our results showed that the laboratory tests of cancer patients had the following characteristics: low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm." } ] } ] } ], "best_biomarker_role": [ { "role": "monitoring" }, { "role": "prognostic" } ], "evidence_source": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" }, { "id": "32425269", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32425269", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome." } ] }, { "id": "32240105", "database": "PubMed", "url": "", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Elevated CRP levels are linked with severe inflammatory response in COVID-19 patients and predict poor clinical outcomes." } ] }, { "id": "32677844", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32677844", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant." } ] }, { "id": "32347972", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32347972", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e213.1; severe: 35.0\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e239.2; critical: 66.1\u201a\u00c4\u00e2\u00ac\u00b1\u201a\u00c4\u00e267.3; in mg/L; P\u201a\u00c4\u00e2=\u201a\u00c4\u00e2.002)." } ] }, { "id": "33349241", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33349241", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented." } ] }, { "id": "32161940", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32161940", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19." } ] }, { "id": "32566572", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32566572", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission." } ] }, { "id": "32296824", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32296824", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19." } ] }, { "id": "32368728", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32368728", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms." } ] }, { "id": "32511972", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32511972", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality." } ] }, { "id": "32344321", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32344321", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19." } ] }, { "id": "32615866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32615866", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19." } ] }, { "id": "32471703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32471703", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room." } ] }, { "id": "32414383", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32414383", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration." } ] }, { "id": "32048163", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32048163", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury." } ] }, { "id": "32369209", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32369209", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Our results showed that the laboratory tests of cancer patients had the following characteristics: low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm." } ] }, { "id": "32388230", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32388230", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Patient 1: CRP level peaked at 332 mg/L.Patient 2: CRP level was 368 mg/L.Patient 3: CRP level was 396 mg/L." } ] }, { "id": "32259132", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32259132", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Our findings suggest that level of LDH, CRP, ALT and NEU can be used to predict the result of COVID-19 test." } ] }, { "id": "32324595", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32324595", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Inflammatory biomarkers such as CRP and erythrocyte sedimentation rate were increased." } ] }, { "id": "32669866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32669866", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The measurement of CRP was increased by 79.93% in all patients." } ] }, { "id": "32503382", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32503382", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Erythrocyte sedimentation rate (ESR) (R=0.55, p < .01) was positively associated with CT severity scores. To sum up, we can conclude from the analysis of published studies that hematological (lymphocyte count, neutrophil count, and NLR), inflammatory (CRP, ESR, IL-6), and especially biochemical (D-dimer, Troponins, CK) parameters correlate with severe prognosis or exitus in COVID-19 patients and can therefore be used as predictive biomarkers." } ] }, { "id": "32766546", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32766546", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "On multivariable analysis, the risk factors found to be significantly associated with admission to intensive care were age above 50 years old, a qSOFA score above 0, smoking, elevated CRP and elevated procalcitonin levels. Asthma, smoking and elevated procalcitonin levels correlated significantly with mortality in our cohort." } ] }, { "id": "32589600", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32589600", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Many biomarkers have been associated with poor outcomes and represent a candidate for risk stratification models for predicting severe COVID-19 in order to guide clinical care. Among all, lymphopenia, thrombocytopenia, leucocytosis, CRP, PCT, LDH, AST, ALT, D-dimer, cTn represent the most predictive parameters of severe COVID-19" } ] }, { "id": "32492406", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32492406", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "Compared to non-severe patients, severe patients showed significant suppression of lymphocyte count and monocyte count, as well as increase of CRP and AST." } ] } ], "crossref": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5", "categories": [ "Biomarkers" ] } ], "citation": [ { "title": "Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19.", "journal": "The Journal of allergy and clinical immunology", "authors": "Herold T, Jurinovic V, Arnreich C, Lipworth BJ, Hellmuth JC, von Bergwelt-Baildon M, Klein M, Weinberger T", "date": "2020", "reference": [ { "type": "PubMed", "id": "32425269", "url": "https://glygen.org/publication/PubMed/32425269" } ], "evidence": [ { "id": "BD0261-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis.", "journal": "The Journal of infection", "authors": "Li H, Xiang X, Ren H, Xu L, Zhao L, Chen X, Long H, Wang Q, Wu Q", "date": "2020", "reference": [ { "type": "PubMed", "id": "32277967", "url": "https://glygen.org/publication/PubMed/32277967" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "The association between biomarkers and clinical outcomes in novel coronavirus\u00a0pneumonia in a US cohort.", "journal": "Biomarkers in medicine", "authors": "Ayanian Shant, Reyes Juan, Lynn Lei, Teufel Karolyn", "date": "2020-08", "reference": [ { "type": "PubMed", "id": "32677844", "url": "https://glygen.org/publication/PubMed/32677844" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Elevations of serum cancer biomarkers correlate with severity of COVID-19.", "journal": "Journal of medical virology", "authors": "Wei X, Su J, Yang K, Wei J, Wan H, Cao X, Tan W, Wang H", "date": "2020", "reference": [ { "type": "PubMed", "id": "32347972", "url": "https://glygen.org/publication/PubMed/32347972" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study.", "journal": "BMC infectious diseases", "authors": "Gong Jing, Dong Hui, Xia Qing-Song, Huang Zhao-Yi, Wang Ding-Kun, Zhao Yan, Liu Wen-Hua, Tu Sheng-Hao, Zhang Ming-Min, Wang Qi, Lu Fu-Er", "date": "2020-12-21", "reference": [ { "type": "PubMed", "id": "33349241", "url": "https://glygen.org/publication/PubMed/33349241" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China.", "journal": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America", "authors": "Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS", "date": "2020", "reference": [ { "type": "PubMed", "id": "32161940", "url": "https://glygen.org/publication/PubMed/32161940" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Combined use of the neutrophil-to-lymphocyte ratio and CRP to predict 7-day disease severity in 84 hospitalized patients with COVID-19 pneumonia: a retrospective cohort study.", "journal": "Annals of translational medicine", "authors": "Liu YP, Li GM, He J, Liu Y, Li M, Zhang R, Li YL, Wu YZ, Diao B", "date": "2020", "reference": [ { "type": "PubMed", "id": "32566572", "url": "https://glygen.org/publication/PubMed/32566572" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "C-reactive protein levels in the early stage of COVID-19.", "journal": "Medecine et maladies infectieuses", "authors": "Wang L", "date": "2020", "reference": [ { "type": "PubMed", "id": "32243911", "url": "https://glygen.org/publication/PubMed/32243911" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "The role of biomarkers in diagnosis of COVID-19 - A systematic review.", "journal": "Life sciences", "authors": "Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A", "date": "2020", "reference": [ { "type": "PubMed", "id": "32475810", "url": "https://glygen.org/publication/PubMed/32475810" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "A Tool for Early Prediction of Severe Coronavirus Disease 2019 (COVID-19): A Multicenter Study Using the Risk Nomogram in Wuhan and Guangdong, China.", "journal": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America", "authors": "Gong J, Ou J, Qiu X, Jie Y, Chen Y, Yuan L, Cao J, Tan M, Xu W, Zheng F, Shi Y, Hu B", "date": "2020", "reference": [ { "type": "PubMed", "id": "32296824", "url": "https://glygen.org/publication/PubMed/32296824" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early.", "journal": "Journal of medical virology", "authors": "Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y, Jiang X, Li X", "date": "2020", "reference": [ { "type": "PubMed", "id": "32281668", "url": "https://glygen.org/publication/PubMed/32281668" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Eosinopenia and elevated C-reactive protein facilitate triage of COVID-19 patients in fever clinic: A retrospective case-control study.", "journal": "EClinicalMedicine", "authors": "Li Q, Ding X, Xia G, Chen HG, Chen F, Geng Z, Xu L, Lei S, Pan A, Wang L, Wang Z", "date": "2020", "reference": [ { "type": "PubMed", "id": "32368728", "url": "https://glygen.org/publication/PubMed/32368728" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "C-reactive protein: A promising biomarker for poor prognosis in COVID-19 infection.", "journal": "Clinica chimica acta; international journal of clinical chemistry", "authors": "Sahu BR, Kampa RK, Padhi A, Panda AK", "date": "2020", "reference": [ { "type": "PubMed", "id": "32511972", "url": "https://glygen.org/publication/PubMed/32511972" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19.", "journal": "Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology", "authors": "Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y, Li B, Song X, Zhou X", "date": "2020", "reference": [ { "type": "PubMed", "id": "32344321", "url": "https://glygen.org/publication/PubMed/32344321" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis.", "journal": "Therapeutic advances in respiratory disease", "authors": "Huang Ian, Pranata Raymond, Lim Michael Anthonius, Oehadian Amaylia, Alisjahbana Bachti", "date": "2020", "reference": [ { "type": "PubMed", "id": "32615866", "url": "https://glygen.org/publication/PubMed/32615866" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Laboratory Biomarkers Predicting COVID-19 Severity in the Emergency Room.", "journal": "Archives of medical research", "authors": "Assandri R, Buscarini E, Canetta C, Scartabellati A, Vigano G, Montanelli A", "date": "2020", "reference": [ { "type": "PubMed", "id": "32471703", "url": "https://glygen.org/publication/PubMed/32471703" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Plasma CRP level is positively associated with the severity of COVID-19.", "journal": "Annals of clinical microbiology and antimicrobials", "authors": "Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z", "date": "2020", "reference": [ { "type": "PubMed", "id": "32414383", "url": "https://glygen.org/publication/PubMed/32414383" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.", "journal": "Science China. Life sciences", "authors": "Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L", "date": "2020", "reference": [ { "type": "PubMed", "id": "32048163", "url": "https://glygen.org/publication/PubMed/32048163" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Clinical characteristics and outcomes of cancer patients with COVID-19.", "journal": "Journal of medical virology", "authors": "Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X", "date": "2020", "reference": [ { "type": "PubMed", "id": "32369209", "url": "https://glygen.org/publication/PubMed/32369209" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Covid-19 infection in therapy-naive patients with B-cell chronic lymphocytic leukemia.", "journal": "Leukemia research", "authors": "Paneesha S, Pratt G, Parry H, Moss P", "date": "2020", "reference": [ { "type": "PubMed", "id": "32388230", "url": "https://glygen.org/publication/PubMed/32388230" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study.", "journal": "Archives of academic emergency medicine", "authors": "Mardani Rajab, Ahmadi Vasmehjani Abbas, Zali Fatemeh, Gholami Alireza, Mousavi Nasab Seyed Dawood, Kaghazian Hooman, Kaviani Mehdi, Ahmadi Nayebali", "date": "2020", "reference": [ { "type": "PubMed", "id": "32259132", "url": "https://glygen.org/publication/PubMed/32259132" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "The laboratory tests and host immunity of COVID-19 patients with different severity of illness.", "journal": "JCI insight", "authors": "Wang Feng, Hou Hongyan, Luo Ying, Tang Guoxing, Wu Shiji, Huang Min, Liu Weiyong, Zhu Yaowu, Lin Qun, Mao Liyan, Fang Minghao, Zhang Huilan, Sun Ziyong", "date": "2020-05-21", "reference": [ { "type": "PubMed", "id": "32324595", "url": "https://glygen.org/publication/PubMed/32324595" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19).", "journal": "Journal of inflammation research", "authors": "Gholizadeh Pourya, Safari Rohollah, Marofi Parham, Zeinalzadeh Elham, Pagliano Pasquale, Ganbarov Khudaverdi, Esposito Silvano, Khodadadi Ehsaneh, Yousefi Mehdi, Samadi Kafil Hossein", "date": "2020", "reference": [ { "type": "PubMed", "id": "32669866", "url": "https://glygen.org/publication/PubMed/32669866" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Biomarkers associated with COVID-19 disease progression.", "journal": "Critical reviews in clinical laboratory sciences", "authors": "Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T", "date": "2020", "reference": [ { "type": "PubMed", "id": "32503382", "url": "https://glygen.org/publication/PubMed/32503382" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait.", "journal": "EClinicalMedicine", "authors": "Almazeedi Sulaiman, Al-Youha Sarah, Jamal Mohammad H, Al-Haddad Mohannad, Al-Muhaini Ali, Al-Ghimlas Fahad, Al-Sabah Salman", "date": "2020-07", "reference": [ { "type": "PubMed", "id": "32766546", "url": "https://glygen.org/publication/PubMed/32766546" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19).", "journal": "Diagnosis (Berlin, Germany)", "authors": "Ciaccio Marcello, Agnello Luisa", "date": "2020-11-18", "reference": [ { "type": "PubMed", "id": "32589600", "url": "https://glygen.org/publication/PubMed/32589600" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] }, { "title": "Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.", "journal": "Cell", "authors": "Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L, Ge W, Liu W, Liang S, Chen H, Zhang Y, Li J, Xu J, He Z, Chen B, Wang J, Yan H, Zheng Y, Wang D, Zhu J, Kong Z, Kang Z, Liang X, Ding X, Ruan G, Xiang N, Cai X, Gao H, Li L, Li S, Xiao Q, Lu T, Zhu Y, Liu H, Chen H, Guo T", "date": "2020", "reference": [ { "type": "PubMed", "id": "32492406", "url": "https://glygen.org/publication/PubMed/32492406" } ], "evidence": [ { "id": "AN6290-5", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6290-5" } ] } ], "section_stats": [ { "table_id": "biomarker_component", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "biomarker", "assessed_biomarker_entity_id", "assessed_entity_type", "assessed_biomarker_entity.recommended_name" ] }, { "table_id": "citation", "table_stats": [ { "field": "total", "count": 27 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }