{
    "biomarker_id": "AN6278-8",
    "biomarker_canonical_id": "AN6278",
    "condition": {
        "recommended_name": {
            "id": "DOID:11394",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11394",
            "name": "adult respiratory distress syndrome",
            "description": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia."
        },
        "synonyms": [
            {
                "id": "DOID:11394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11394",
                "name": "ARDS",
                "description": ""
            },
            {
                "id": "DOID:11394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11394",
                "name": "Non-cardiogenic pulmonary edema",
                "description": ""
            },
            {
                "id": "DOID:11394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11394",
                "name": "Shock lung",
                "description": ""
            },
            {
                "id": "DOID:11394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11394",
                "name": "adult RDS",
                "description": ""
            },
            {
                "id": "DOID:11394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11394",
                "name": "acute respiratory distress syndrome",
                "description": ""
            }
        ],
        "id": "DOID:11394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL6 level",
            "assessed_biomarker_entity_id": "P05231-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-6",
                "synonyms": [
                    {
                        "synonym": "Interferon beta-2"
                    },
                    {
                        "synonym": "IFN-beta-2"
                    },
                    {
                        "synonym": "CTL differentiation factor"
                    },
                    {
                        "synonym": "CDF"
                    },
                    {
                        "synonym": "B-cell stimulatory factor 2"
                    },
                    {
                        "synonym": "BSF-2"
                    },
                    {
                        "synonym": "Hybridoma growth factor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood plasma",
                    "namespace": "UBERON",
                    "id": "0001969",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001969",
                    "loinc_code": "26881-3"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6278-8",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-8"
                },
                {
                    "id": "32479790",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32479790",
                    "tags": [
                        "assessed_biomarker_entity",
                        " assessed_biomarker_entity_id",
                        " biomarker"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IL-6 elevation in plasma are connected with poor outcomes in ARDS, causing inflammation and lung damage."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6278-8",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-8"
        },
        {
            "id": "32479790",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32479790",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IL-6 elevation in plasma are connected with poor outcomes in ARDS, causing inflammation and lung damage."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6278-8",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-8",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study.",
            "journal": "The Lancet. Oncology",
            "authors": "Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, Cai Y, Lu Z, Wang J, Wang Y, Liu S, Cheng B, Wang J, Zhang M, Wang L, Niu S, Yao Z, Deng X, Zhou F, Wei W, Li Q, Chen X, Chen W, Yang Q, Wu S, Fan J, Shu B, Hu Z, Wang S, Yang XP, Liu W, Miao X, Wang Z",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32479790",
                    "url": "https://glygen.org/publication/PubMed/32479790"
                }
            ],
            "evidence": [
                {
                    "id": "AN6278-7",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-8"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}