{
    "biomarker_id": "AN6278-1",
    "biomarker_canonical_id": "AN6278",
    "condition": {
        "recommended_name": {
            "id": "DOID:10283",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:10283",
            "name": "prostate cancer",
            "description": "A male reproductive organ cancer that is located_in the prostate."
        },
        "synonyms": [
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "NGP - new growth of prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "hereditary prostate cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "malignant tumor of the prostate",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate cancer, familial",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostate neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic cancer",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "prostatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:10283",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:10283",
                "name": "tumor of the prostate",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "HPCX1",
                "description": ""
            },
            {
                "id": "MONDO:0010257",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                "name": "prostate cancer, hereditary, X-linked 1",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "HPCX2",
                "description": ""
            },
            {
                "id": "MONDO:0010405",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                "name": "prostate cancer, hereditary, X-linked 2",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "RNASEL familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "familial prostate cancer caused by mutation in RNASEL",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "prostate cancer, hereditary, type 1",
                "description": ""
            },
            {
                "id": "MONDO:0011098",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                "name": "HPC1",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "prostate cancer, hereditary, type 8",
                "description": ""
            },
            {
                "id": "MONDO:0011270",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                "name": "HPC8",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, hereditary, type 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "prostate cancer, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012093",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                "name": "HPC3",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, hereditary, type 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "prostate cancer, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012094",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                "name": "HPC4",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "prostate cancer, hereditary, type 5",
                "description": ""
            },
            {
                "id": "MONDO:0012244",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                "name": "HPC5",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "prostate cancer, hereditary, type 6",
                "description": ""
            },
            {
                "id": "MONDO:0012300",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                "name": "HPC6",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "HPC7",
                "description": ""
            },
            {
                "id": "MONDO:0012470",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                "name": "prostate cancer, hereditary, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "prostate cancer, hereditary, type 9",
                "description": ""
            },
            {
                "id": "MONDO:0012597",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                "name": "HPC9",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "HPC10",
                "description": ""
            },
            {
                "id": "MONDO:0012620",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                "name": "prostate cancer, hereditary, 10",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "EHBP1 familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "familial prostate cancer caused by mutation in EHBP1",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "prostate cancer, hereditary, type 12",
                "description": ""
            },
            {
                "id": "MONDO:0012741",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                "name": "HPC12",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "MSMB familial prostate cancer",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "familial prostate cancer caused by mutation in MSMB",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "prostate cancer, hereditary, type 13",
                "description": ""
            },
            {
                "id": "MONDO:0012758",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                "name": "HPC13",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "HPC11",
                "description": ""
            },
            {
                "id": "MONDO:0012768",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                "name": "prostate cancer, hereditary, 11",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "HPC14",
                "description": ""
            },
            {
                "id": "MONDO:0012769",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                "name": "prostate cancer, hereditary, 14",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "HPC15",
                "description": ""
            },
            {
                "id": "MONDO:0012770",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                "name": "prostate cancer, hereditary, 15",
                "description": ""
            },
            {
                "id": "MONDO:0700275",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0700275",
                "name": "prostate cancer, hereditary",
                "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents."
            },
            {
                "id": "MIM:601518",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/601518",
                "name": "Prostate cancer, hereditary, 1",
                "description": "Prostate cancer, hereditary, 1"
            },
            {
                "id": "MIM:610997",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/610997",
                "name": "Prostate cancer, hereditary, 9",
                "description": "Prostate cancer, hereditary, 9"
            },
            {
                "id": "MIM:611868",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611868",
                "name": "Prostate cancer, hereditary, 12",
                "description": "Prostate cancer, hereditary, 12"
            },
            {
                "id": "MIM:611928",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611928",
                "name": "Prostate cancer, hereditary, 13",
                "description": "Prostate cancer, hereditary, 13"
            },
            {
                "id": "MIM:611955",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/611955",
                "name": "Prostate cancer, hereditary, 11",
                "description": "Prostate cancer, hereditary, 11"
            },
            {
                "id": "MIM:176807",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/176807",
                "name": "Prostate cancer",
                "description": "Prostate cancer"
            }
        ],
        "id": "DOID:10283"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL6 level",
            "assessed_biomarker_entity_id": "P05231-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-6",
                "synonyms": [
                    {
                        "synonym": "Interferon beta-2"
                    },
                    {
                        "synonym": "IFN-beta-2"
                    },
                    {
                        "synonym": "CTL differentiation factor"
                    },
                    {
                        "synonym": "CDF"
                    },
                    {
                        "synonym": "B-cell stimulatory factor 2"
                    },
                    {
                        "synonym": "BSF-2"
                    },
                    {
                        "synonym": "Hybridoma growth factor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "26881-3"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6278-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-1"
                },
                {
                    "id": "10914713",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/10914713",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Univariate analysis of all patients demonstrated that an extent of disease (EOD) on bone scanning > or = 1, IL-6 > or = 7 pg/ml, PS > or = 1, PSA > 100 ng/ml, and ALP > 620 IU/liter were associated with a significantly lower survival rate than their respective counterparts. In multivariate analysis, however, the only two significant prognostic factors were EOD and IL-6. These results indicate that the serum IL-6 level is a significant prognostic factor for prostate cancer as well as EOD."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6278-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-1"
        },
        {
            "id": "10914713",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/10914713",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Univariate analysis of all patients demonstrated that an extent of disease (EOD) on bone scanning > or = 1, IL-6 > or = 7 pg/ml, PS > or = 1, PSA > 100 ng/ml, and ALP > 620 IU/liter were associated with a significantly lower survival rate than their respective counterparts. In multivariate analysis, however, the only two significant prognostic factors were EOD and IL-6. These results indicate that the serum IL-6 level is a significant prognostic factor for prostate cancer as well as EOD."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6278-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Serum interleukin 6 as a prognostic factor in patients with prostate cancer.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Nakashima J, Tachibana M, Horiguchi Y, Oya M, Ohigashi T, Asakura H, Murai M",
            "date": "2000",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10914713",
                    "url": "https://glygen.org/publication/PubMed/10914713"
                }
            ],
            "evidence": [
                {
                    "id": "BB1513-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
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                "journal",
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    ]
}