[ { "cls_id": "homologset.agr.HGNC:16125", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZA82-1", "uniprot_id": "D3ZA82_RAT", "id": "D3ZA82-1", "name": "", "aln": "MPLPRRGGEPRLAGARVVRTSLPRATPRSPKRVGRGAPLLSHAQRLTRRRHSSEQVPPEPEHADFRSGKWLQERAGGDARDLRHTPLARMGSRQRVSGTEEVVIPCASDSDSGSVDLQLSNLDDIHKGGPSVEFADSDISDIPILPQESLPDNLRSPTLQEPLSEASVERLVQSIQEVLHGDLKGELQKLKFLRSLSSLSQTIPYDESTESFIHRHTAEIVHILTVLVQEEPLHSLNSLVRQEVFVTITDLSYRDVHLLFGSEDREDLLGLITKSMMSLPAICTPIQLPRIVSNQAIQQECLYRGTFETFSVMLQSLVVKDPHLEIFDSIFKHIDPWLQSDRDHERERATFVMAKVLKCLSSYLSPKLPLQFHRLGHLVAVMALLCGDPHKEVAEEAAEGTHYLLHITLRLKYITQDRDS-GKNLRETVKKCRELLEQYN--LKGFYCCPFKIVQVFEVFLDSKELGQFIMTVLDSLKSLPHPYIQQTAGELLITLVKSAEARFEKVPEIIGVICARLSIITLASVRQQIINTVSLFVSRPKYTDIVLSHLLCHPVPYDRHLAELWRTLEVELSSTTWVLWRLLRKLQKCHDGPTQEKMAYVAVAVTDALYEVLMGNKLRAAAFRLFPQLLMTLLIQIHHSIGLTMSDVSIPSGLYAEQEIPTEVTPLCFAIQATKTLLLRTLCWQEFSIMEKNGGWTLLKGEGHLQGVFLLANALMERSHLFAYKIMYLLVPLINRGNDKHKITSAGFFVELLRSPMARRLPRVYSTIRLKTWLNEESKLFRILALRGLRNLVGHREMREDIKSLLPCILNSLYETDERIILLAIQILLQLVRTLDSSTLATMMKTLLSLFGDVRQDVHRFSMTLFGASIKAVKHTEKKSVEDQVLESLVPLLLFSQDENDAIAKESRRVLTLCARFLNWKLPREVYCKDPLYIKPNEVRRVCKFFGERSKGKIDILDQTLTYSKDPKLPIRRTAVLFVGLLSNYVDASELKRKGTDWIENDLRELLQDPEPSLRIIASQALFRIQRVGNIPETEISVSWMRKLLGCLHT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9PYI4-1", "uniprot_id": "E9PYI4_MOUSE", "id": "E9PYI4-1", "name": "", "aln": "MPLPRRGGEPRLAGARVVRTSLPRATPRSPKRVGRGAPLLSHAQRLTRRRHSSEQVPPEPEQADFRSGKWLQERAGGDARDPRHTPLARMGSRQRASGTEEVVIPCASDSDSGSVDLQLSNLDDVQKGGASVEFTDSDIADIPTLPQESLPDNLRLLTLQEPLSETSIERLVQSIQEVLHGELKGETQKLKFLRSLSSLSQTIPYDENTESFIHRHTAEIVHVLSVLVQEEPLHSLTSMVRQEIFVTITDLSFQNVYLLFGSEDREDLLGLITKSIISLPATSTPIQLLKIVSNQAIEQECLYRETFEAFSVMLQSLVIKDPHLEFFDSIFKHIDPWLQSDRDHERERATTVMAQVLKCLSSYLSLKLPLQFQRLGNLVAVMALLCGDPQKEVAEEAAEGTHYLLHITLRLKYIMQDRDNNSKNLRETLKKCRLLLEQYS--LKRFYCCPYKIVQVFEVFLDSRELGQFIMTILDSLKNLPHPCIQQTAGELLITLVKSAEARFERVPEIVGVICARLSIITLTSVRQQIINTVSLFVSRPKYTDVVLSHLLCHPVPYDRHLAELWRSLEVELSNTTWVLWRLLRKLQKCHEGPSQEKMAYVAVAVTDALYEVLMGNKLRAAAFRLFPQLLMTLLIQIHHSIGLTMSDVSIPSGLYAEQEVPMEVTPLCFAIQATKTLLLRTLCWQEFSIMEKSGGWTLLKGEGHLQGVFLLANALMERSHLFAYKILYLLVPLINRGNDKHKLTSAGFFVELLKSPMARRLPKVYSTIRLKAWLNEESKLFRILALRGLRNLVRHQEMREDIKSLLPCILSSLHETDERIILLAIQILLQLVRMLDSTTLATMMKTLLSLFGDVRQDVHCFSMTLFGASIKAVKHTEKKSVEDQVLESLVPLLLFSQDENDEIAKESRRVLTLCARFLNWKLPREVYCKDPLYIKPNEVRRVCKFFGEKSKGKIDILDQTLPYSKDPKLPIRRTAVLFVGLLSHYVDTSELKRKGTDWIEKDLRELLQDPEPSLRILASQALFRIQRVGSTSEAETSVSWLRKLLCCLHT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H579-1", "uniprot_id": "MROH8_HUMAN", "id": "Q9H579-1", "name": "Protein MROH8", "aln": "-----------------------------------------------------------------------------------------MSSKHRICSQEEVVIPCAYDSDSESVDLELSNLEIIKKGSSSIELTDLDIPDIPGLHCEPLSHSPRHLTQQDPLSEAIVEKLIQSIQKVFNGELKGELEKLKFLGDLSSLSQALPYDETAKSFIHSHIADIVHTLNVLVQEERPHSLSSSMRQEVFVTIADLSYQDVHLLLGSEDRAELFSLTIKSIITLPSVRTLTQIQEIMPNGTCNTECLYRQTFQAFSEMLQSLVVKDPHLENLDTIIK-----------------------------------LPLRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKD-QQNLKRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSIISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAVSP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.*::* .. ******** **** ****:****: ::**..*:*::* **.*** * *.*... * * *:****: :*:*:****:*::*:**** :***** .******::****.::**** * *:*** *.****** ***.* :***:****:***:::*:**:***** :*:.* **:::**: * *: .*:.* : : ***** **::** ******:****** :*:*:* ***:*:***:***:********:::******** * *********** :*:.. :**:.::.*** :** :. * ** **::*.**** ****.** ***** :*:**.* ** **::*****:**.*.:*::**:****:*****:****: . ************:*******:***.********:*****:** *.***..***:************: *:***********: ", "identical_positions": 309, "similar_positions": 117, "identity": "29.4%" }, { "cls_id": "homologset.agr.HGNC:16126", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZYG2-1", "uniprot_id": "A0A8I5ZYG2_RAT", "id": "A0A8I5ZYG2-1", "name": "", "aln": "MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWKEEMKSKGQNDEENAQEAPQVKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAIIALGTIKEWLAKNHQEVDRIIFCVFLEVDFKIYKKKMNEFFPIDDNNEGAADADTKEEAEGPEPKGLSPPHKKSKAKKLESSKDSNEVLLKDESGPEEKQTAEGMEGQSQEAGGLRVLLRSLLGLIHRDGVNTTPVPS-PASEDK-AEVHKDEADSAKD--DNTTKESEVTNHSVCDQELPNGQENDSTKSEGKTETESPSSSMETEDLSPNQEDATIVEEPEVIPLIDDQEEQEGGEAQGEEAPAVFAESQGSSEAENTSGPD-VDMNSQVDGVN-EMTESLQEDLQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UYG8-1", "uniprot_id": "MACD2_MOUSE", "id": "Q3UYG8-1", "name": "ADP-ribose glycohydrolase MACROD2", "aln": "MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWKEEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAVIALGTIKEWLAKNHQEVDRIIFCVFLEVDFKIYKKKMNEFFPVDDNNEG-TDADMKEDSEGPEPKGLSPPHKKSKAKKPESSKDSS----EDESGPEEKQTAEEMEGQSQEAGGLRFLLRNLLGLIHRDGVNTTPVPS-PASEDK-AEVHKDE-DSAKD--DNTVKDSDMTNHSVCDQELPNGQENDSAKSEGKTEAESPSSSMETEDLSPNQEDAAIVEQPEVIPLIDDQEAQEGGEAQGKDAPAVFAESQGSSEAENTSGPD-VDMNSQVDGVN-EPTESLQEDLQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A1Z1Q3-2", "uniprot_id": "MACD2_HUMAN", "id": "A1Z1Q3-2", "name": "ADP-ribose glycohydrolase MACROD2", "aln": "MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDS--------------------------------DENGPEEKQSVEEMEEQSQDA----------------DGVNTVTVPG-PASEEA-VEDCKDE-DFAKD--ENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPD-AGAQDEAKEQR-NGTK-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z9J2-1", "uniprot_id": "A0A8M6Z9J2_DANRE", "id": "A0A8M6Z9J2-1", "name": "", "aln": "---MSKKKKEWRAEKERLLSLSLEDRRKDYRGNYLELDKIPTWANHDSNTATEEEE------HQSSSLADKVSLYKGDITILEIDAIVNAANSSLLGGGGVDGCIHRAAGHLLYEECHSLNGCDTGKAKITCGYDLPAKYVIHTVGPIARGNVGQSQRDDLESCYYSSLKLMKDNNLRSVAFPCISTGIYGFPNEPAAEIALKTVQEWIEKHQDEIDRVIFCVFLETDYEIYKRKMSDFFSPDNDDRKKEDDGKMEQGETQPMEGDGGDEEDGDEDGDEDDEEDD-----DKKDQKDVEMMSQTEETQEDVPMDSQKPADSSQAETLDKENKTPEKGDPRVEGSPAAKKKDEQELKKDKGDDPLVLGEEKEQSPGKKKMQKGQADE----EGKPVEDSTKSADTGPGIS--QEDLMEVEAEQQTTLTVITSEADKNVTATKENTSSSTKDEVNAQDKSSKEPDSAPTDSRPNSEDGQGKKSAQE---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .**** ** ******.::**:***:* :*: *..* :* :. .... ::** : ..**::*****:****:**:********:***************** * **:.****:**:************************::. *:::** .** *****:*:**:********************* *** *::**: *::.*:**:*******.*::***:**.:**. *:::. * *:. *:.. :: : . * .::. * *... . * * . *** : ** :: .: .::* .:. .** :: * * :* .* :* *** ** : .* . : : :: . :.: .:: :.: ** . :.. . : .: ", "identical_positions": 184, "similar_positions": 121, "identity": "37.78%" }, { "cls_id": "homologset.agr.HGNC:16127", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AKE7-1", "uniprot_id": "ACL10_MOUSE", "id": "A2AKE7-1", "name": "Actin-like protein 10", "aln": "MKPRIVLKSSSLMPSWDRPVLPGAPGCELAGGVARAHPIKHGVVVDWDALEGLWERLMVGGLQVHPEQWPVLVSDSPSAPPKGREKVAELLFEALTVPACHMANTALLALCSIGAFSGLAVEAGAGVCHATPIYAGHSWHKATFRLNVAGSTLSRYFRDLLVAACPDLQLQGLSRKTVTQLKKRCCYVSLDFQGDICDPARHQRACFCLGNGCYVRLGSERFRCPEPIFQPSLLGHPEPGLPTLAFQALQKIPTTLRTRLANTVVLAGGSTLFPGFVERMNLELEAQCRRHGYPALQPCLVAHPGRDTAVWTGGSMMASLNSFQCRWMTRAMYQEHGPLLVRDVFD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LRP6-1", "uniprot_id": "A0ABK0LRP6_RAT", "id": "A0ABK0LRP6-1", "name": "", "aln": "------------MPSWDRPVLPGVPGCELAGGVARAHPIKHGVVVDWDALEGLWERLMVGGLQIHPEQWPVLVSDSPSAPPEGREKVAELLFEALTVPACHMASTALLALCSVGAFSGLAVEAGAGVCHATPIYAGHSWHKATFRLNVAGSTLSRYFRDLLVASCPDLQLHALPRKTVTQLKKRCCYVSLDFQGDICDPARHQRACFCLGKGCYVRLGSERFRCPEPIFQPSLLGHPEPGLPTLAFQALQKIPTTLRTRLANTVVLAGGSTLFPGFVERMNLELQAQCRRHGYPALQPCLVAHPGRGTAVWTGGSMMASLHSFQRRWMTRAMYQEYGPFLVREVFD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5JWF8-1", "uniprot_id": "ACL10_HUMAN", "id": "Q5JWF8-1", "name": "Actin-like protein 10", "aln": "-----------------------------------------------------------------------------------------------------MASTALLALCSTGAFSGLAVEAGAGVCHATPIYAGHSWHQATFRLNVAGSTLSRYLRDLLVAANPDLLQQALPRKAITHLKKRSCYVSLDFEGDLRDPARHHPASFSVGNGCCVCLSSERFRCPEPIFQPGLLGQAEQGLPALAFRALQKMPKTLRTRLADTVVLAGGSTLFPGFAERLDKELEAQCRRHGYAALRPHLVAKHGRGMAVWTGGSMVASLHSFQRRWITRAMYQECGSRLLYDVFN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **.******** ***************************:***************:******: *** :.*.**::*:****.*******:**: *****: *.*.:*:** * *.*************.***:.* ***:***:****:*.*******:**************.**:: **:********.**:* ***: **. ********:***:*** **:******* *. *: :**:", "identical_positions": 186, "similar_positions": 42, "identity": "53.76%" }, { "cls_id": "homologset.agr.HGNC:16128", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIL6-1", "uniprot_id": "ABHGB_RAT", "id": "Q5XIL6-1", "name": "ABHD16B", "aln": "-------------------------MCVICFVKALVHVFKIYLTANYSYNFRSWP--VDFRWDDLHVPGTNNSSHRALTCAAAAAGVWLLHDAALG---------------EDALTRPPRGARSQVQ-------------------------------CLLQQIRELPSQLASYALAHSLGRWLVYPGSMFLMTRALLPLLQQGQERLVDRYRGRRAKLVACDGNEIDTMFMDRRQHPGSHGRGLCLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGGSTGAPFPQHDANAMDVVVKYALHRLHFSPANVVVYGWSIGGFTATWATMTYPELGALVLDATFDDLVPLALKVMPQSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSGHVPSLPSCQVEGDVEGNRGNELLLRLLEHRYPSVMAREGRTVVIRWLRASNLAQETALYARYHVDDEWCLATLRSYREGRQKDLDHTKTWGPHGPSFPWFVGQGLSARRRRHLALFLARRHLKNLEATHCSPLEPEDFQLPWRL---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80YU0-1", "uniprot_id": "ABHGB_MOUSE", "id": "Q80YU0-1", "name": "ABHD16B", "aln": "-------------------------MCVICFVKALVHVFKIYLTANYSYNFRSWP--VDFRWDDLHAPSTGNSSQRALTCAAAAAGVWLLHDAALG---------------GDTLTRPPRGARSQVQ-------------------------------CLLQQIRELPSQLASYALAHSLGRWLVYPGSMFLMTRALMPLLQQGQERLVDRYRGRRAKLVACDGNEIDTMFMDRRQHPGSHGRGLCLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGGSTGAPFPQHDANAMDVVVKYALHRLNFPPAHVVVYGWSIGGFTATWATMTYPELGALVLDATFDDLVPLALKVMPQSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSNHIPSMPSCQVEGDVEGNRGNELLLRLLQHRYPSVMAREGRTVVTRWLRASNLAQETALYARYRVDDEWCLATLRSYRERCQKELDDAEAWGPHGLSFPWFVGQGLSARRRRQLALFLARRHLKNLEATHCSPLEPEDFQLPWRL---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3Z7-1", "uniprot_id": "ABHGB_HUMAN", "id": "Q9H3Z7-1", "name": "ABHD16B", "aln": "-------------------------MCVICFVKALVRVFKIYLTASYTYPFRGWP--VAFRWDDVRAVGR-SSSHRALTCAAAAAGVWLLRDETLG---------------GDALGRPPRGARSQAQ-------------------------------CLLQQLRELPGQLASYALAHSLGRWLVYPGSVSLMTRALLPLLQQGQERLVERYHGRRAKLVACDGNEIDTMFMDRRQHPGSHVHGPRLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGSSTGVPFPQHDANAMDVVVEYALHRLHFPPAHLVVYGWSVGGFTATWATMTYPELGALVLDATFDDLVPLALKVMPHSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSGRLRPLS----PGDVEGNRGNELLLRLLEHRYPVVMAREGRAVVTRWLRAGSLAQEAAFYARYRVDEDWCLALLRSYRARCEEELEGEEALGPHGPAFPWLVGQGLSSRRRRRLALFLARKHLKNVEATHFSPLEPEEFQLPWRL---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VZF1-1", "uniprot_id": "Q9VZF1_DROME", "id": "Q9VZF1-1", "name": "", "aln": "MSFLNYVFGPNLYMEYRGVPEPQRKMYEAGAVEKFGEQILSTLSVMWSVGYYTSPLLVTFLYRRGYLVTDSIPTLAKITTSVGLIVILSLVMRGLGRKQSRSYSNMIKALVRAKSSKAPGDANSELRRFDIEFNAWPVDFDVKALTGDTKKPVVTARRREPIQLATLPCEAIAYLAINTFGLSMIYPGSVKLLQKLMRPMLISGRAKLIEDDNGIRYKVKTIDSNEIDTLFIDNR--PNNVGNGKTLVICSEGNAGFYEVGIMATPVALKYSVLGWNHPGFAGSTGTPHPHQDKNAIDAVVQFAINNLRFPVEDIILYGWSIGGFSTLYAASVYPDVKGVVLDATFDDVLYLAVPRMPAALAGIVKVAIRNYCNLNNAELANEFNGPISFIRRTEDEIIAEDN------------HIDTNRGNFLVLSVLKHRYPNIFG-----ASQLNKAKGLLSKPLEPYSIPVADEKLCMSRLITYASD-------------EGKSFPMNIGADYSEEVRNLMAVFLLRKHLRDYNSTHCTQLPGEFFTMPWDIPTEQGFVFT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *: : . : *:. :: : * * * : .: :* :.. : * ** :.* .*.*: : *: ** : :* :::* ::****: *: : : *:* .*: :*:: .* * *: : *.*****:*:*.* *.. .* ****.********:* :::*: ***********..***.*.*::* **:*.**::*::.*.*. .:::****:***:: :*: .**:: .:********:: **: ** : *:* ::*:: *** ** : **: ::***:*:::: .. .:: **** *:* :*:**** ::. . . *:: *: .*:. *:: * :* .* :** :* . * . *. :*:** *:**:: ::** : * * * :** : ", "identical_positions": 152, "similar_positions": 142, "identity": "27.34%" }, { "cls_id": "homologset.agr.HGNC:16129", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9BYL1-1", "uniprot_id": "SAM10_HUMAN", "id": "Q9BYL1-1", "name": "Sterile alpha motif domain-containing protein 10", "aln": "----------------------------------------------------------------------------MFTELRSKLSPPRGR---------AGAV---------RAGFG------------------------------------ERRDVDATAHFS-----------------FCRTLLEHTVSAESIPCHLPRTPGTSLTWHDSRSQRAASSRPIKLLQQPGTDTPQGRLYSDHYGLYHTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNAEKLQRMGLAQEAQRQEVLQQVLRLQVREEGRSLQLLSQASFGKMS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7TST3-1", "uniprot_id": "SAM10_MOUSE", "id": "Q7TST3-1", "name": "Sterile alpha motif domain-containing protein 10", "aln": "----------------------------------------------------------------------------MFTELRSKLSPPRAR---------AGAV---------RPGFG------------------------------------ERPDVDASAHFS-----------------FCQTLLEHTVSAENIPCHLPRTPGTSLTWHDSRSQRASSSRPIKLLQQPGSEIPQARLYSDHYGLYHTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNADKLQRMGLTQEAQRQEVLQQVLHLQVREEGRSLKLLSQASFGNMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M2I9-1", "uniprot_id": "F1M2I9_RAT", "id": "F1M2I9-1", "name": "", "aln": "KRNEQIRIHRYLGENDPDLGQTEQVKAHRCDYPHHHQTEGTSLANCKGRPAGCKRGWSTESYPGAQGRLLLWRTSSAYAARRAADTPPSSRSAPCAQGWAAGALPRRLPGRGDRLGLGRLRRVGTRCALPTGHSGCLVLREGRVPEPRIRGLHVHRAAVKAEPPASSRRGCAYRLRGAPGCGRFCQTLLEHTVSAENIPCHLPRTPGTSLTWHDSRSQRASSSRPIKLLQQPGSETPQARLYSDHYGLYHTSPSLGGLTRPVVLWSQQDVCKWLKKHCPHNYLVYVEAFSQHAITGRALLRLNADKLQRMGLTQEAQRQEVLQQVLHLQVREEGRSLQLLSQASFGNMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M1QVC1-1", "uniprot_id": "A0A8M1QVC1_DANRE", "id": "A0A8M1QVC1-1", "name": "", "aln": "------------------------------------------------------------MQQTANSLIKIFALGGVVQEHQLLLLPERTG-HPWAWQTPTEAIT-------ERYAFIP------------------------------------TMAVDAASSFS-----------------FCRAALEHTISAEELNYQLPRRAGGNLTWHEGHEQRVTR-RTVKLLQQPGTEGIQIQP-GEAFTVYHTSPTLSSLCKPVVLWTQQDVCKWLKKHCPHNYLTYVEAFSHHAITGRALLRLNGEKLARMGIIQETLRQEVLQQVLQLQVREEVRNLQLLSRASFGNIS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8ML92-1", "uniprot_id": "AVE_DROME", "id": "Q8ML92-1", "name": "Protein aveugle", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGEETINSTQNKTR-----------------------------------------------TKTTRPKAVYLWTVSDVLKWYRRHCG-EYTQYEQLFAQHDITGRALLRITDSSLQRMGVTDNRDREAIWREIVKQRLKTDIMEIRDMERLNIY---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. * : : : :.* **: .** ** ::** :* * : *::* ********:. ..* ***: :: *: : ::::: ::: : .:: :.: .: ", "identical_positions": 27, "similar_positions": 41, "identity": "7.74%" }, { "cls_id": "homologset.agr.HGNC:1613", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JK72-1", "uniprot_id": "CCS_RAT", "id": "Q9JK72-1", "name": "Copper chaperone for superoxide dismutase", "aln": "------------------MASKSGDGGTMCALEFTVQMS--CQSCVDAVHKTLKGAAGVQNVEVQLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSSQLKNLGAAVAIME------GSGTVQGVVRFLQLSSEL---CLIEGTIDGL-EPGLHGLHVHQYGDLTKDCSSCGDHFNPDGASHGGPQD--TDRHRGDLGNVHAEASGRATFRIEDKQLKVWDVIGRSLVVDEGEDDLGRGGHPLSKVTGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGQGRKDSAQPPAHL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WU84-1", "uniprot_id": "CCS_MOUSE", "id": "Q9WU84-1", "name": "Copper chaperone for superoxide dismutase", "aln": "------------------MASKSGDGGTVCALEFAVQMS--CQSCVDAVHKTLKGVAGVQNVDVQLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSSQLQNLGAAVAILE------GCGSIQGVVRFLQLSSEL---CLIEGTIDGL-EPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQD--TDRHRGDLGNVRAEAGGRATFRIEDKQLKVWDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGQGRKDSAQPPAHL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14618-1", "uniprot_id": "CCS_HUMAN", "id": "O14618-1", "name": "Copper chaperone for superoxide dismutase", "aln": "------------------MASDSGNQGTLCTLEFAVQMT--CQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILG------GPGTVQGVVRFLQLTPER---CLIEGTIDGL-EPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQD--SDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58FYM8-1", "uniprot_id": "A0AC58FYM8_DANRE", "id": "A0AC58FYM8-1", "name": "Copper chaperone for superoxide dismutase", "aln": "MRFHTLIWINDFDDVTPHFSLSSDFQDLRFLLEFAVQMS--CDSCVNAVKAVLEKDPGVQSVQVNLSKEEVLVETALTSLQVQTLIESTGRRAVLKGMGGSDSD-LGAAVAMLS------GAGLVQGVVRFLQLSQDR---CLIDGTIDGL-SPGAHGLHVHELGDLTQDCRSCGDHFNPFRKQHGAPQD--SDRHVGDLGNISAGPDGRASFRLEDSQIKVWDVIGRSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGIIARSAGLFQNPKQICACDGVTLWEERDRPIAGRGRRVETHT-SHL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E1JH26-1", "uniprot_id": "CCS_DROME", "id": "E1JH26-1", "name": "Copper chaperone for superoxide dismutase", "aln": "------------------MSS--------IKIEFAVQMRRGDESYAGALRSALDG---VGQVEIDTQEGRVIIQTQRPWSEIQDKIEATGVRAVLSGFGGQSAVALINTTGSVV------DKTPIQGVVRFTTITADKKPGVVVDGVVDGL-SPGLHGLHIHESGDTSAGCSSVGEHYNPRQSPHGSPAAGAEERHAGDLGNIRADENGRATFRFVDPVLEVWDIIGRAVVLTANADDLGRGGNDQSLIDGNSGERIACGIIARSAGILENFKRICACDGVTLWDERNKPLAGKERSQKL------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40202-1", "uniprot_id": "CCS1_YEAST", "id": "P40202-1", "name": "Superoxide dismutase 1 copper chaperone", "aln": "------------------MTTN-----DTYEATYAIPMH--CENCVNDIKACLKNVPGINSLNFDIEQQIMSVESSVAPSTIINTLRNCGKDAIIRGAGKPNSSAVAILETFQKYTIDQKKDTAVRGLARIVQVGENK---TLFDITVNGVPEAGNYHASIHEKGDVSKGVESTGKVWHKFDEPIECFNE-------SDLG-----KNLYSGKTFLSAPLPTWQLIGRSFVISKS---LNHPENEPSSVKDYS----FLGVIARSAGVWENNKQVCACTGKTVWEERKDALANNIK----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: ::: * :. .. :: *. : .::.. .. : :.: . : :. * *:: * * . : ::*:.*: : : :.: .::*: ..* : :*: ** : . * *. :: .*** . : : . : .*::***:.:: . *.: : * . * *:******: :* *::*:* * *:*:** .:*.. : ", "identical_positions": 42, "similar_positions": 87, "identity": "13.73%" }, { "cls_id": "homologset.agr.HGNC:16130", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A0Q5-1", "uniprot_id": "D4A0Q5_RAT", "id": "D4A0Q5-1", "name": "", "aln": "MKSAKLGFLLGFSLFCLLSPPVLSFVEKVAARLCKEFNDPCALEMDPGSCYESHYRFFYNQTSKKCQIFVFSGCNGNRNNFMLKIDCDVMCNEEYKVKPQ-SQETR-------------SHLRVTSPQPGGLKQTERKPTGRQRARRESGRQPLARHHAE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D263-1", "uniprot_id": "SPIT4_MOUSE", "id": "Q9D263-1", "name": "Kunitz-type protease inhibitor 4", "aln": "MKPTKLGFLLGLSLLCSLSPPVLSGVERLANYLCKDYNDPCLLDVEPGSCYEVHFRFFYNQTAKQCQIFLFTGCNGNLNNFKLKIDCDVTCHETYKNPPLPSGDKRKRSLRALATKNLATDWRLTTLQPGRLRQTERKETLLQRARRESRRQPLARHHT-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6UDR6-1", "uniprot_id": "SPIT4_HUMAN", "id": "Q6UDR6-1", "name": "Kunitz-type protease inhibitor 4", "aln": "MKSAKLGFLLRFFIFCSLNTLLLGGVNKIAEKICGDLKDPCKLDMNFGSCYEVHFRYFYNRTSKRCETFVFSGCNGNLNNFKLKIEREVACVAKYK-PPR------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.:****** : ::* *.. :*. *:::* :* : :*** *::: ***** *:*:***:*:*:*: *:*:***** *** ***: :* * ** * ", "identical_positions": 49, "similar_positions": 28, "identity": "30.62%" }, { "cls_id": "homologset.agr.HGNC:16131", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5DQQ6-1", "uniprot_id": "WFD13_MOUSE", "id": "Q5DQQ6-1", "name": "WAP four-disulfide core domain protein 13", "aln": "MRPVSPLQLLLVLSLAPQPVLGSPKQYFLKYILEPPPCRSEPGACNMFCTQQEECPEPLQCCSAYCGIVCTSN-----------QAPVLGLS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LMQ1-1", "uniprot_id": "A0ABK0LMQ1_RAT", "id": "A0ABK0LMQ1-1", "name": "WAP four-disulfide core domain 13", "aln": "MTPVPPFQLLLVLSLAPQLVPASPKQYFLKYVLEPPPCRSEPDICDTFCTEQEECSPNLQCCSAYCGIVCTSN-----------QAPVVGVS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IUB5-1", "uniprot_id": "WFD13_HUMAN", "id": "Q8IUB5-1", "name": "WAP four-disulfide core domain protein 13", "aln": "MKPVLPLQFLVVFCLALQLVPGSPKQRVLKYILEPPPCISAPENCTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKHKGSEVIMPAN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* ** *:*:*:*:.** * * .**** .***:****** * * * :** **:* :****::*****:*: : *: : ", "identical_positions": 43, "similar_positions": 18, "identity": "46.24%" }, { "cls_id": "homologset.agr.HGNC:16132", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D975-1", "uniprot_id": "SRXN1_MOUSE", "id": "Q9D975-1", "name": "Sulfiredoxin-1", "aln": "MGLR----AGGALRRAGAGPGAP------------------EGQGP-GGAQGGSIHSGCIATVHNVPIAVLIRPLPSVLDPAKVQSLVDTIL---------------ADPDS--VPPIDVLWIKGAQGGDYYYSFGGCHRYAAYQQLQRET------IPAKLVRSTLSDLRMYLGASTPDLQ-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYN0-1", "uniprot_id": "SRXN1_HUMAN", "id": "Q9BYN0-1", "name": "Sulfiredoxin-1", "aln": "MGLR----AGGTLGRAGAGRGAP------------------EGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIR---------------EDPDS--VPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRET------IPAKLVQSTLSDLRVYLGASTPDLQ-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5Q8-1", "uniprot_id": "A0ACD6B5Q8_DANRE", "id": "A0ACD6B5Q8-1", "name": "Sulfiredoxin-1", "aln": "MEGR----WGQTEPNAFTLKILSGDIRNFIVN---PLRIHMRNMGS-LSSENRSIHSDNIQDVHNIPMGVIIRPIPPVLDEQKVQSLMTSIQ---------------ECSDISVVPPIDVLWITGEKGGNYYYSFGGCHRFAAYQRLKMKS------IPAKIIKSNISDLRTYLGASTPNLQ-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VX10-1", "uniprot_id": "SRX_DROME", "id": "Q9VX10-1", "name": "Sulfiredoxin", "aln": "MEFISHFLRATSRRTAALGPILQRNRSEIIQKQSLTNRQAFRRYRSSCSTMDTTVHSAGIDETHLVPMSVIQRPIPSVLDEQKVQSLMETIK---------------NETSEDEVPPIDLLWISGSEGGDYYFSFGGCHRFEAYKRLQRPT------IKAKLVKSTLGDLYHYMGSSAPKYLA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36077-1", "uniprot_id": "SRX1_YEAST", "id": "P36077-1", "name": "Sulfiredoxin", "aln": "----------------------------------------------------MSLQSNSVKPT-EIPLSEIRRPLAPVLDPQKIDAMVATMKGIPTASKTCSLEQAEAAASAGELPPVDVLGVR-VKGQTLYYAFGGCHRLQAYDRRARETQNAAFPVRCRVLPATPRQIRMYLGSSLDIE--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :::* : . :*:. : **:..*** *::::: :: .. :**:*:* : :* :::****** **.: : : .::: :. :: *:*:* ", "identical_positions": 24, "similar_positions": 43, "identity": "13.11%" }, { "cls_id": "homologset.agr.HGNC:16133", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D9I4-1", "uniprot_id": "TBC20_MOUSE", "id": "Q9D9I4-1", "name": "TBC1 domain family member 20", "aln": "MALR--------PSKGDG-SAGRWDR---GAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLLTDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDE-QREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATS---------------------LVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHV---VRLYDFFLACHPLMPIYFAAVIVLYR----------------EQEVLDCDCDMAS---VHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAAS--------TFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKP------RTNRFVKLAVMG------------LTVALGAAALAVVKSALEWAPKFQLQLFP--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABZ3NN82-1", "uniprot_id": "A0ABZ3NN82_RAT", "id": "A0ABZ3NN82-1", "name": "", "aln": "MALR--------PSEGDG-SAGRWNR---GSGKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRCQVWPKLLNVNTDEPPPMSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDE-QREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATS---------------------LVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLLDFRH------------------------VIVLYR----------------EQEVLDCDCDMAS---VHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAAS--------TFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKP------RTNRFVKLAVMG------------LTVALGAAALAVVKSALEWAPKFQLQLFP--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96BZ9-1", "uniprot_id": "TBC20_HUMAN", "id": "Q96BZ9-1", "name": "TBC1 domain family member 20", "aln": "MALR--------SAQGDGPTSGHWDG---GAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEE-QREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATS---------------------LVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHV---VRLYDFFLACHPLMPIYFAAVIVLYR----------------EQEVLDCDCDMAS---VHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQQAERTAAS--------TFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLTKP------RTNRFVKLAVMG------------LTVALGAAALAVVKSALEWAPKFQLQLFP--------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P43570-1", "uniprot_id": "GYP8_YEAST", "id": "P43570-1", "name": "GTPase-activating protein GYP8", "aln": "MPLRSLFHTNQSSHDKDALTRGGYNAYLESLSRCDSGKAEEQKGKVISKLLEKK--DVRALRYIGLGPLGFVNNSLRKDCWYELLASQLLIDDATEYITPVEKHKDEGQVILDAERSFG----GIVDKNLKLQLRKLLVELITRVLRKYPTLNYYQGYHDIVSVFIMCFSWNVTKENGLELENLSLQEEIDMERLFYCIEAFTLLYLRDFMMNSLDFSFEQLRVISSLIKESNMKFYNLFKFDENEPLFAIGSILTIFAHNLKPIDSGDNNLHKILFQIFDMTISMQSMRLPLIIYKNLLLQNASEISKQIEANSDFFENDFDLRHGAIQTVLQKKLYDEALWEEVLQITRKDATTASKKALKRVSLNKYSALLNTACGKPGCFDMSTIIFYLSEQTKMNEHYKEEKYHGVAAR-SKTRALVQRLGHFLPSKYNRWSKISLLIGIVAILYQLRTTRSLSLVLNLRYMISTKLKDLSHININLHHVSHIWVDPIRDILKLGHPTR", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.** . . *. : * :: . :.* . .::* * : *:.. *: *** :.:. *::.:.:* . * :** : . . : ** **:**..**: *: :: : *:: *:::* :* : * *:********* .*:: .. .::.. :* :: :***** ::* : . *. : .:*.: . ::::::: * .:**:. ::* *.* * : :::*: :.:.:: * *: * .:: :: :* ::. : . . . . * * : : .* .:*. : * *:. : : .::::*: :*: :: : : **: *:::: :::* ::.: *: .:::::*. ", "identical_positions": 78, "similar_positions": 159, "identity": "15.48%" }, { "cls_id": "homologset.agr.HGNC:16134", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R5Z9-1", "uniprot_id": "M0R5Z9_RAT", "id": "M0R5Z9-1", "name": "", "aln": "MQQPRVETDIIGAGEGPQRAAPWSAWVLRQDWVRWWVCHIPRSWAQWWNTSGWR----QPLQRMLWGLEGTLYLLLALMLCHALFTTGS-------HLLSSLWPVVAVMWSHLLPAVLLLVLSALPALLFAASFLLLFS---TLLSLVGLLTSMTHPGYAQDLDQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NUB4-1", "uniprot_id": "CT141_HUMAN", "id": "Q9NUB4-1", "name": "Uncharacterized protein C20orf141", "aln": "MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVLWLGALGLTIQAVFSTTGPALLLLLVSFLTFDLLHRPAGHTLPQRKLLTRGQSQGAGEGPGQQEALLLQMGTVSGQLSLQDALLLLLMGLGPLLRACGMPLTLLGLAFCLHPWA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : : . * . .* . ** *. **** :: * .:* :: :* ***. :* . *: : :**: . * . *:** : :. * : ::***: .** *: :: .:. . ", "identical_positions": 31, "similar_positions": 39, "identity": "18.79%" }, { "cls_id": "homologset.agr.HGNC:16135", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZWT2-1", "uniprot_id": "D3ZWT2_RAT", "id": "D3ZWT2-1", "name": "", "aln": "-------------------------------------------MEHLERCAWFLRGTLVR--AAVRRHLPW-------VLVAAMLVGSALKELS-PLPESYLSNKRNVLNVYFVKLA-----------------WAWTVCLLLPFIALTNYHLTG---KTSLVLRRLSTLLVGTAIWYMCTALFSNIEHYTG------SCYQSPALEGIRQEHRTKQQ-CHREGGFWYG-FDISGHSFLLTFCALMIVEEMAVLHEVKTDRSHHLHV-----------------------------------AITTLVVALGFLTFIWVW------MFLCTAVYFHDLIQKVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSSSLTLKQDTYKK---------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59266-1", "uniprot_id": "FITM2_MOUSE", "id": "P59266-1", "name": "Acyl-coenzyme A diphosphatase FITM2", "aln": "-------------------------------------------MEHLERCAWFLRGTLVR--ATVRRHLPW-------ALVAAMLAGSVVKELS-PLPESYLSNKRNVLNVYFVKLA-----------------WAWTVCLLLPFIALTNYHLTG---KTSLVLRRLSTLLVGTAIWYICTALFSNIEHYTG------SCYQSPALEGIRQEHRSKQQ-CHREGGFWHG-FDISGHSFLLTFCALMIVEEMAVLHEVKTDRGHHLHA-----------------------------------AITTLVVALGFLTFIWVW------MFLCTAVYFHDLTQKVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSCSLTLKRDTYKK---------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N6M3-1", "uniprot_id": "FITM2_HUMAN", "id": "Q8N6M3-1", "name": "Acyl-coenzyme A diphosphatase FITM2", "aln": "-------------------------------------------MEHLERCEWLLRGTLVR--AAVRRYLPW-------ALVASMLAGSLLKELS-PLPESYLSNKRNVLNVYFVKVA-----------------WAWTFCLLLPFIALTNYHLTG---KAGLVLRRLSTLLVGTAIWYICTSIFSNIEHYTG------SCYQSPALEGVRKEHQSKQQ-CHQEGGFWHG-FDISGHSFLLTFCALMIVEEMSVLHEVKTDRSHCLHT-----------------------------------AITTLVVALGILTFIWVL------MFLCTAVYFHNLSQKVFGTLFGLLSWYGTYGFWYPKAFSPGLPPQSCSLNLKQDSYKK---------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q52KL1-1", "uniprot_id": "FITM2_DANRE", "id": "Q52KL1-1", "name": "Acyl-coenzyme A diphosphatase FITM2", "aln": "-------------------------------------------MAAAVAGSLVDKLVCLWRQPYTRIYLPH-------LFFCISLVGSVLKNAE-LVPESYFSSSRNVLNLYFVKVS-----------------WGWTIVLLLPFIAYSNFYIK----SHMFALRRLTSLLVATLVWYICTETFFYIEDITG------SCYESNTMVVIRGEFDTKAA-CRKAGFFWDG-FDISGHSFILSYSSLVIMEEMVPMLHIQP---AYRNP-----------------------------------PLDCLYLALNVIVAIWIW------MFGCTSVYFHDIIDKILGTSCGILGWYMTYKVWYVKLFSPGLPPQP-----KQHT------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VRJ2-1", "uniprot_id": "FITM2_DROME", "id": "Q9VRJ2-1", "name": "Acyl-coenzyme A diphosphatase FITM2", "aln": "-MATKRRPLRPNLGGTAGSPSSSGSNMNFRPGGPDITRSEARGTRPTAAPTSIREILVMGVIHLCKKTIFFNTDLKVALYLGSLFVISVIGDFV-PFPKTYFARSDNLFNQYFVKIG-----------------WGWTLLFVVPFLVLSAYTITCG-DHKRMLRHHFPRIVIATFFWFFWTKLFNVVENSYG------RCTT--------KGYATKSS-CLKAGHLWKG-FDISGHAFILIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQFLYKRLTPIIRTLFIGMAALQLLWDI------MLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYPTPGLLPEAPGNGSFSYQREIPTFPFKRPSHLSTGAATTSSGSNSSRTNLNGKAATTGVPRDQQIPTFMGMPLFTSPKAASAAANLLMSDQQKRERDREQQTLES", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53012-1", "uniprot_id": "SCS3_YEAST", "id": "P53012-1", "name": "Acyl-coenzyme A diphosphatase SCS3", "aln": "MSSKWFNAIHLLVCPLTVLVGYLMNAYGYGAALQATLNKDGLVNAMLVKKGWFWTSLVGWWCIIRYRAVPGATGRDRRHIVQSFKRYAILTVWWYVFTQGIWFGVGPIMDLVFVYTGGHCHYDVFDDAGHVNEDFQGSVTRTNRALALIHNVLTLHGHHQEHRQQQLWDRSIGSIQGALQATQPKTPKNVTASAAAAINTFIHDQMHRWQGPLTTSAQ-CRRFGGHWAGGHDPSGHVFLATLMCMFLLGELRVFGRRALAHLYAQKW-----------------------------------QLVRLVTRLFDTGPLWTWRRCGGGSMTCGARLWRAIVEPPVTCAAALLRLTRCIACDHPVIILLTLLVTWLWQLLLTAVASRFHTVREHMSGLLAAYIVTGLVYARDAAALRPV-------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q06676-1", "uniprot_id": "YFT2_YEAST", "id": "Q06676-1", "name": "Acyl-coenzyme A diphosphatase YFT2", "aln": "----------------------------MIRQLNYWSRKAYLIYPFQVFVGALLSIVVSSETLNHQKETCA--------LLKSSNIFNVIFAYKANQLWPFLFFSLAFLQIYFHYLAR-----------------MDILPLPISSTETSSSYLTYTN-HWPLLKNRIISIMITQYACKFVLKYLLLFLNFQFID----HVFIWTGGECSSGSKTTSAEKCRLENGKWDGGFDISGHFCFLVSISMILWMELHLFSRFVQAEDMFWVVN---------------------------------KWVRACLAIVCAVLVIWIC------ILWVTAIYYHTILEKVLGCLMGFICPVFIYHILPKIGILHNYLYL----------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : .:: * . . :. .:: : : . :. * . * * .* *** : .:.: * : . : : :* : :: : : . .:: ", "identical_positions": 10, "similar_positions": 39, "identity": "2.15%" }, { "cls_id": "homologset.agr.HGNC:16136", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9H4G8-1", "uniprot_id": "DPH3B_HUMAN", "id": "Q9H4G8-1", "name": "Putative DPH3 homolog B", "aln": "MAVFHDEVEIEDFQYDEDSETYFCPCPCGDNFSITKEELENGEGVAMCPGCSLIIKVIYDKDQFACGETVPVPSVNKE---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8K0W9-1", "uniprot_id": "DPH3_MOUSE", "id": "Q8K0W9-1", "name": "Diphthamide biosynthesis protein 3", "aln": "MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFAITKEDLENGEDVATCPSCSLIIKVIYDKDQFMCGETVPAPSTNKELVKC-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VGQ9-1", "uniprot_id": "DPH3_DROME", "id": "Q9VGQ9-1", "name": "Diphthamide biosynthesis protein 3", "aln": "MSIYHDEVEIEDFEYDEEEEMYYYPCPCGDRFQISKEELIEGEEVATCPSCSLVIKVIYDPEMFKAEEDE-ESALNEKLGDLKLEKN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q3E840-1", "uniprot_id": "DPH3_YEAST", "id": "Q3E840-1", "name": "Diphthamide biosynthesis protein 3", "aln": "MSTY-DEIEIEDMTFEPENQMFTYPCPCGDRFQIYLDDMFEGEKVAVCPSCSLMIDVVFDKEDLAEYYEEAGIHPPEPIAAAA----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: : **:****: :: :.: : ******.* * ::: :** ** **.***:*.*::* : : : ", "identical_positions": 27, "similar_positions": 23, "identity": "31.03%" }, { "cls_id": "homologset.agr.HGNC:16137", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZXX8-1", "uniprot_id": "A0A8I5ZXX8_RAT", "id": "A0A8I5ZXX8-1", "name": "", "aln": "MGNSGSHKRTKAPNQASKDRPPDMDKARHKQFFSHLKRKKPS---------------------------------TKIVLLFPLDKRQQLAEAAAGPFVRPVRPAEDPLGAPTCFPATVAPMLRGAGDGVDRREGARAREMKRILVLLLQLDARLQEEGRRVAGRPGGGAKAQQYWQPLYAHLLTQREACGEGDPREEQPRKRRRCPRPRP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AKE5-1", "uniprot_id": "A2AKE5_MOUSE", "id": "A2AKE5-1", "name": "", "aln": "MGNSSSHKRTKAPNQANKDRPPDMDKARHKQFFSHLKRKKPSPMASQHATFPFFQWREAPDPARVGENPRIKAGKTKIVLLFPLDKRQQLAEAAAGPFVRPVRPTEDPLGAPTCFPA-VAPMLRGAGDGVDRREGARAREMKRILVLLLQLDARLQEEGRRVGGRPGGGAKVPQCWQPLYAHVLTQRDACGEGDPREEQPRKRRRCPRPRP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BQM9-1", "uniprot_id": "CT144_HUMAN", "id": "Q9BQM9-1", "name": "Uncharacterized protein C20orf144", "aln": "MGNYSSHKRTKAPKQARKERPADMDKAWWKSFLNHLTRKKPA---------------------------------TRIVLILPLDKRQPLANAGQ----RIDYASGAGLGSP------AAPRLRGAGEGSEREP-----RMP-VLLLLRRQEARRPEEG---------GARAALSWPRLLSRFRSPGKAPREAGPAEEQPRKRCRCPRPQL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** .********:** *:**.***** *.*:.**.****: *:***::****** **:*. * .: **:* .** *****:* :*. .* :*:** : :** *** **:. * * ::. : .* *..* ******* *****: ", "identical_positions": 83, "similar_positions": 36, "identity": "39.34%" }, { "cls_id": "homologset.agr.HGNC:16139", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBW4-1", "uniprot_id": "D3ZBW4_RAT", "id": "D3ZBW4-1", "name": "", "aln": "MLSKTLLLILGVLLLLSLAQGGVQ-RKRRYEVQSRSEVKECERKPKLYLCRRHCESDQDCQANNICCSTTCGNVCVNLLDNSVWETPVTPPPDIVYPESGSQPSFEGDMVLPTSPLSPFSTAADK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H1F0-1", "uniprot_id": "WF10A_HUMAN", "id": "Q9H1F0-1", "name": "WAP four-disulfide core domain protein 10A", "aln": "MAPQTLLPVLVLCVLLLQAQGGYRDKKRMQKTQLSPEIKVCQQQPKLYLCKHLCESHRDCQANNICCSTYCGNVCMSIL----------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* .:*** :* : :** **** : :** :.* .*:* *:::******:: ***.:*********** *****:.:* ", "identical_positions": 43, "similar_positions": 21, "identity": "34.4%" }, { "cls_id": "homologset.agr.HGNC:16140", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5M969-1", "uniprot_id": "NANP_RAT", "id": "Q5M969-1", "name": "N-acylneuraminate-9-phosphatase", "aln": "--------------------MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEVICDKVQVKLSKECFHPYS-TCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKSTRLQHMTLEEDVKAMLTELRKE-VRLLLLTNGDRQTQREKIEACACQSYFDAIVVGGEQKEEKPAPSIFYHCCDLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKSGGVPLTS-----SPMPHYMVSSVLELPALLQSIDCKVSMSV--------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CPT3-1", "uniprot_id": "NANP_MOUSE", "id": "Q9CPT3-1", "name": "N-acylneuraminate-9-phosphatase", "aln": "--------------------MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYS-TCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKSTRLQHMILADDVKAMLTELRKE-VRLLLLTNGDRQTQREKIEACACQSYFDAIVIGGEQKEEKPAPSIFYHCCDLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKSGRVPLTS-----SPMPHYMVSSVLELPALLQSIDCKVSMSV--------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TBE9-1", "uniprot_id": "NANP_HUMAN", "id": "Q8TBE9-1", "name": "N-acylneuraminate-9-phosphatase", "aln": "--------------------MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN-TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKE-VRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKS-----SPVPHYMVSSVLELPALLQSIDCKVSMST--------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N6L1-1", "uniprot_id": "A0A8M1N6L1_DANRE", "id": "A0A8M1N6L1-1", "name": "", "aln": "-------------------MMGSRGVLSIIFDLDNTLIDTAGAGRTAIQKVCELLKSTHVQESHIRDICERFLRKLLQESFDPSEGKTIDDVRIQHWCEALQETPGTDPDPALASRCYYTWKNTRLQALSLSSEVRALLEELQKN-YKLLLLTNGDTQTQREKIEAVRCEGLFSLVVVGGDHPEQKPARSIFTHCFESAGVRPQDCIMVGDSLTTDIQGGVNAGVRATVWINAGSKSLPQD-----SVTPDYTLPTVLHLKEVLAQLA---------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W481-1", "uniprot_id": "Q9W481_DROME", "id": "Q9W481-1", "name": "", "aln": "MAASKFHCGKQLTATHSHFDATCAKIRAFYFDLDNTLIPTRAGDSKAIRKLADFLETQYQFSKDDATQATQNFLKAFRRCPDNSQ-TSLDSWRTHLWRESLPAR-----HKHLAEQIYPKWLKLRYRYLAVPADYVQLLLRMRQAGYALALITNGPSNAQWEKVAELNVRGYFDCVLVSSDLPWEKPHPEIFYAACNFLNVKPQECVMIGDKLETDIKGGHLAQLGLTFWTPLSNSSAAAQSLEDVEYKPHVKLGSLLEMYKYFPRLNSVALPEMPSVSRRRGSHMSPISQGSGSGSSSSAICVPGAGHGYHHHHHQQHQEQQQQHHHHHHQRQWLYRRGVSLPAMDCSNSEAENSCDSFL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. ******** * ... .: :: .:*:: : ... . : * :.. . . . : . * * *:: . **.. * * . * : : : : :* .::: * *:*** ::* **: .. *. :::..: :** .** . : .*:* :*:*:**.* ***:** * : *.* .. . . *. : ::*.: : : ", "identical_positions": 50, "similar_positions": 81, "identity": "13.85%" }, { "cls_id": "homologset.agr.HGNC:16142", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5PR01-1", "uniprot_id": "PPDPF_RAT", "id": "Q5PR01-1", "name": "Pancreatic progenitor cell differentiation and proliferation factor", "aln": "MAAIPSSGSLVATHDYYRRRLGSSSSNSSGGSAEYPGDAVPHSPGLPKADSGHWWASFFFGKSTLPFMAA-VLESPEHSAESPQASRSPISCGLAPETMKKQPVMHPSQTNSRAPS-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CR37-1", "uniprot_id": "PPDPF_MOUSE", "id": "Q9CR37-1", "name": "Pancreatic progenitor cell differentiation and proliferation factor", "aln": "MAAIPSSGSLVATHDYYRRRLGSSSSSSSGGSAEYPGDAVLQSPGLPKADPGHWWASFFFGKSTLPFMTT-VLESPERSAESPQVSRSPMTCGLTPETMKQQPVIHSGQTNPRDLS-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3Y8-1", "uniprot_id": "PPDPF_HUMAN", "id": "Q9H3Y8-1", "name": "Pancreatic progenitor cell differentiation and proliferation factor", "aln": "MAAIPSSGSLVATHDYYRRRLGSTSSNSSCSSTECPGEAIPHPPGLPKADPGHWWASFFFGKSTLPFMAT-VLESAEHS-EPPQASSSMTACGLARDAPRKQPGGQSSTASAGPPS-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PFP3-1", "uniprot_id": "PDPFA_DANRE", "id": "Q6PFP3-1", "name": "Pancreatic progenitor cell differentiation and proliferation factor A", "aln": "MAAIPSSGSLIATHDYYRRRIGSTSSNSSCSSSEYTGEVIPHPPGLARQDSGHWWSSFFFGKQNQ--MGTPNGFESQQKTGTYTVTNGQVTC-VAREIVMKRHLSESSDSGK-EPGSPLPS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6PBI2-1", "uniprot_id": "PDPFB_DANRE", "id": "Q6PBI2-1", "name": "Pancreatic progenitor cell differentiation and proliferation factor B", "aln": "MAAIPASGSLVATHDYYRRRIGSTSSSSSCGSSEYSGEVIPHHPGLPKQDSGHWWSSFFFGKQNLPGMGT-VAEEAQQKSGVVSVTNGQVTC-VAREMVMR-QASESSDGGKSEAGNS---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****:****:*********:**:**.** .*:* .*:.: : ***.: *.****:******.. * : ..::. .: . :* :: : : ... . . ", "identical_positions": 43, "similar_positions": 37, "identity": "35.54%" }, { "cls_id": "homologset.agr.HGNC:16143", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A922-1", "uniprot_id": "A0A8I6A922_RAT", "id": "A0A8I6A922-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------MQARRGQWAAARRRGAAAHSSMAAAAAGGAPGPAPGPARPAP------AARNPPAVPRRRGDSRRRQAALFFLNNISLDGR-PPSLGPGGEKPLPPPPPPTEAREAPAPPPAPPGGLPGLPAR-----------PAPQGLLSPTTAPAS----------------------------LGLDGQRQRRRVTSQRCSLEFLEDAVGCAS--VQRTK-----HASGSPRHKGLKKTHFIKNMRQYDTKNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGGG--GGVSVSSEMVFELEGVELGADGKVVSYAKFLYPTNALVTHKND------------------------SHGLLPQPRPSIPRAPPGSRHKPVPTKSTPAG-TELGSDGGDAVEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVKPADLKKDMNETFREKFPHIKLTLSKIRSLKREMRNLSE-ECSLEPVTVSMAYVYFEKLALQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLIDVSVRSWRKGSGSTGRISLDLSSRCLWLWNWPCTSRRTKYYLTTDASPSSSSPEQCTPQGACFGRKASSLARALTSSVPVLPLVTALAPQSRAALSFPWKEALLLFWSVPHLHLEALLRVFLKQMNIVGLGLLFMCLRPAWFMLSILRSSFHFA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K3M5-1", "uniprot_id": "CABL2_MOUSE", "id": "Q8K3M5-1", "name": "CDK5 and ABL1 enzyme substrate 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAAAGGAPGPAPGPSRPAP------AARNPPAVPRRRGDSRRRQAALFFLNNISLDGR-PPSLGPGGEKPAPPPPPPTEAREAPAPPPAPPGGLPGLPAR-----------PAPQGLLSPTTAPAG----------------------------LGLDGQRQRRRVTSQRCSLEFLEDTVGCAS--VQRTK-----HASGSPRHKGLKKTHFIKNMRQYDTKNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGG-----VSVSSEMVFELEGVELGADGKVVSYAKFLYPTNALVIHKND------------------------SHGLLPQPRPSIPRAPPGSRHKPVPTKSTPAG-TELGSDGGDAVEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVKPADLKKDMNETFREKFPHIKLTLSKIRSLKREMRNLSE-ECSLEPVTVSMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLRKSEVKQLIDKLEERFR------------------------------------------------------FNRKD------------------------LIGFEFTVLVALELALYLPENQVLPHYRRLTQQF-----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BTV7-1", "uniprot_id": "CABL2_HUMAN", "id": "Q9BTV7-1", "name": "CDK5 and ABL1 enzyme substrate 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAAAGGAPGPAPGPAGPPPPAAPTSAARAPPQALRRRGDSRRRQAALFFLNNISLDGR-PPSLGPGGEK---PPPPPAEAREPPAPPPPEPP--TGLPART----------PAPQGLLSPTQVPTG----------------------------LGLDGQRQRKRVTSQRCSLEFLEDAVGCAP--AQRTK-----HTSGSPRHKGLKKTHFIKNMRQYDTRNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGG-----VSVSSEMVFELEGVELGADGKVVSYAKFLYPTNALVTHKSD------------------------SHGLLPTPRPSVPRTLPGSRHKPAPTKSAPAS-TELGSDVGDTLEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVKPSDLKKDMNETFREKFPHVKLTLSKIRSLKREMRSLSE-ECSLEPVTVAMAYVYFEKLVLQGKLSKQNRKLCAGACVLLAAKISSDLRKSGVTQLIDKLEERFR------------------------------------------------------FNRRD------------------------LIGFEFTVLVALELALYLPENQVLPHYRRLTQQF-----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q830-1", "uniprot_id": "A0A8M9Q830_DANRE", "id": "A0A8M9Q830-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAACGPRGCPRTNSAKPHK------------ELLRKSRDSRRRQAALLFLTNISLDGRPVYNLSNGLVGPREVDSRCVDVGAAVAGLPLSTTSSYGTFTQVSSSISGGAATPIPRTNVNTYPAPMSPPPALNQGSSDVFTEDGRSDPLSVQAPPLSPTAGPRNTALGSSKSPSQFP--SSNPLPDPRQRTR-----NLSGSPGPKVSKKVHFIKNMRQYDTRGSRVVLICAKRSLCAAFSVLPYGESYHISDSKLEAQRQRHSSGG-----GS---DMVPGLEGVEVD-FGKTVSYARFLLPTNALVRLKSSG-----------------------QTDISTAQMPMSRNRINGQKNFTPSRISSTIG-QDTG--VDELSEYDPNLLSDPQWPCGKHKRVLIFASYVTTVIEYVKPSDLKKDMNETFKEKFPHIKLTFSKIRSLKREMRSVSE-ECGLQPVTIAMAYVYFEKLVLQGRLNKHNRKLVSAACVLLAAKISSDLKKQEVKQLIDRLEERFR------------------------------------------------------INRKE------------------------LISLEFTVLVALEMALYLPDSKVMPHYRRLVQQG-----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7F0B6-1", "uniprot_id": "E7F0B6_DANRE", "id": "E7F0B6-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAACSTQSTLNPCTGKLHR------------EHLRKNKDSRRRQAALLFLTNISLDGRPVRN-NVIATAPSDAEFQCADIATAVNELSAAASSD-GTFSSLPVPRLG--LLGVPPILVLPSDSGFS-----NAGSSEMFLERTRG-SFSSQSNLLSPCS-LQPTPLGPRKSPTLLSVQSCGSSLDSRPRSR-----NASGSPRPRSMKKIHFIKNMRQYDTRGSRIVLICAKRSLCAAFSVLPYGESFHISDPLLDAQRRRHSSGG-----ISTTLEMLPGLEGVELGLYGRTVSYAQFLYPTNALDRHKPS-------------------------VDL-TLPLPFSRNSIP--RSYPSSRLNSTVG-LDLG--LED-SDYDPNMLSDPQWPCGKHKRVLIFASYMTTVIEYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREIRLVGE-ESCLQPVTIAMAFVYFEKLVLQGRLNKQNRKLVAAACLLLAAKISSDLKKQEVKQLIDKLEERFR------------------------------------------------------ISRRE------------------------LIAFEFTILVALEMALYLPESKVMPHYRQLVQQT-----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KF19-1", "uniprot_id": "A0A0B4KF19_DROME", "id": "A0A0B4KF19-1", "name": "Cyclin N-terminal domain-containing protein", "aln": "MASSLNKTRHRRRLAAISFLSNISLDGTHRDTKFGATFGSSLLCNQNKNPSSLGLGSGGFHPHYQQHHHQRSHSATHHNHQKRHHTQQQQQQQQQQHTQQQQQQQQHQQQHQQQQQHQNGALCSPLLCSADVHMGIDGGIGLGLGLEDCTTGASDGDGHFSETENMGQYLMNVLPAADHNRSSIVPAERRNIKRPTSSGRHNHQAPGNGNMGNKLQQQQQQQHKLQQQQRQARSCAAGSGGSGAESGSDSDSVKIPLKVSNLGSGGGVAGGAGSKLLPLRERTFSNGASDQNLQPERRARLN---------------TAPGMRVGSNSSIAMGGGLKRTYVLSGSSVSHITDDSSTESLTPAGNYAGSFRNSLSKSVQISDSRRGTSGQPLGLGQARDERMVLVSRKIPFFIFSSLPYYKGKNGRAEFRKEDRRRRNPSTSRPLSSINDAPFDPFDLLGIQKAESGQDISYGHLLIPSRQYEKERKKHGNASANPSIFENQMEITSTAALKNHGIARCFTYENNNRNSATSPTPDMKLDMDIESVILGGDSSRGQVYSASILDDPELIAGKHRTLLTFTSYMTSVIDYVRPSDLKKELNDKFREKFPTIQLTLSKLRSIKREMRRINKLDSRIDLVTISQAYVYFEKLILANLINKSNRKLCAGACLLLSAKMN-DVKGDALKSLIEKTESVFR------------------------------------------------------LNRKE------------------------LISSEFAVLVALEFSLHVNRHEVLPHYQRLLYESXDWPKRCAEKSFLAAAQAVQQLCRKGSRK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.** . . . . :::* * : . :.* . .. * : . : . :. . : : . . : : . * * :: : : :::..*:**:. * .: *: * :: : :::*:.* . . * *:: *: :**.::* *:. : . .: . . . * *...:*.**: .***: :* *:**:*:**:**:*:****::*:.*:**** ::**:**:**:***:* :.: :. :: **:: *:****** * . :.* **** :.**:**:**:. *:: . :..**: :* :.*: . .*. ** : : .: . : : : ", "identical_positions": 90, "similar_positions": 138, "identity": "10.71%" }, { "cls_id": "homologset.agr.HGNC:16144", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JTF0-1", "uniprot_id": "A0A0G2JTF0_RAT", "id": "A0A0G2JTF0-1", "name": "", "aln": "MDSFMESLNRLKEAHEKEVLGLQNKLLELNSERCRDAQRVEELFAKNHQLREQQKALKENLRVLENRLRAGLCDRCMVTQELARKKQLELESAHLQSLQHLCVLTNEMNVLREENKILKEEVKRLRNLGDKTTPQTWEGTSEPPSPLPLPSPSNRKGATENPPGGSEEAEEEQ------GTDKLSSHKTSPVARVSPATNLLEPRTLDMTPQCISNQLHSTVAVVRPGSRACPPDSDTANGTPPPPSMRSSPSSPTYEHGLPVDSFLRAARPSAIAYETLKHSLQTDRLCLLNRHLSLHLQSPHSSLLTPAAAPNSPLPRGLKAREAEAWEE-------PSALVGVQDPRLEGALHLLLVQQHLRARARASTARLRVPSAPKEMPSSPPADSDSESSDSEAPKPVLSTEAQPDGWHPPPIGQSSSQRKETLVATQDSPPDKPLDLSDRGRCR--DTSKSTGQPLPLSP----TPDPQLPALSRPLILSSHTLSNGSTETRAQESEEYSTPKDTSQTLSGIHVGLTSPRRTAEEPGGR------PRPGPHLQRPDADGTT------AQRPELEQLGESDASDTKAGLISESSIETSIAGEGQ---HAEDLRRGQQQKRKRASDLQDKAPKKPSQGKRKPKEPLTPADGPRSPRDTEDYSLSPINSCRES-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2ABX0-1", "uniprot_id": "A2ABX0_MOUSE", "id": "A2ABX0-1", "name": "", "aln": "MDSFMESLNRLKEAHEKEVLGLQNKLLELNSERCRDAQRVEELFAKNHQLREQQKALKENLRVLENRLRAGLCDRCMVTQELARKKQLELENAHLQSLQHLCILTNEMNGLREENKILKEEVKRLRSLGDKTAPQAWEGTSEPPSPLPLPSPSSWKGTTENPPGAPEEAEEEQS-----GTDKISSHKTSPVSRVSPAANLPEPRALDMTPQCISNQLHSTVAVVRPGSRACPPDSGSADGTPPP-STRSTPPSPTYEHGLPVDSFLRASRPSAIAYETLKHSLQTDRLCLLNRQLSLRLQSPHSSPLASAVAPHSPLPRGLKAREAEAWEE-------PGALVGMQDPRLEGALHLLLVQQHLRARARASTARLQVPSAPEEMPSSPPAGSDSEGSDSEAPKPALSTEAQPDGWHPQTTGQGSSQRKETHVATQDCPPDKPLDLSDRGRCR--DISKSTGQPLPLSPKIVYTPSPQLPTLSRPLVPSSHTLSNVSTETRAQESEEYSTPKDTSHPLPGVCMGLTSPGRTAEEAGGR------PQPGPHLQRPDTGGTTEPKKVRAQRLALEQLEESDTSDTKAGLISEASAEPSMPGVG----HAEDHQQSQQQKRKRASDLQDKG-TYLREGKAGPGM-----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NC74-1", "uniprot_id": "RB8NL_HUMAN", "id": "Q8NC74-1", "name": "RBBP8 N-terminal-like protein", "aln": "MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKENLRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKEEVKRLRGLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRGEEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPANGTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHLQSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLAQQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPAGPGRAQRTEA-AATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQSGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPPPHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGPECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRK----LTATEGPGSPRDAEDHSPSPNSSPWEET", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:*********** *************************:****:**********:*****************************:* *:*.:***.**:: :****** *:***: *********.***:. *:: ****:***** ****.. *. **:***. *****:: * :* :.*:****:::**.:.* *.*: **:** ******.*:*******:***.* ..*:***** . **:*.**:**:**.:******:****:::*: * * :.******** ***:******* *:.*.** .* :.*********** *.**.*:** **********.**:*******.:.* : .:* ** .* *..****..:.*..:..*:: . ..* *. . * . :**.*: .****.. *******: **.* * .*.:** .*** *..*: *: * ** *.::*** :. **. *.** *** *.*:.*.* :.*:** * :* ** *:* ** * ** .* . . * ::* *:*:..::.** *::. .* .* * ::: :. :******: **. . .*: ", "identical_positions": 351, "similar_positions": 159, "identity": "52.47%" }, { "cls_id": "homologset.agr.HGNC:16145", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8J8XUM3-1", "uniprot_id": "A0A8J8XUM3_RAT", "id": "A0A8J8XUM3-1", "name": "Cyclic nucleotide-binding domain-containing protein 2", "aln": "---------------------------------------------------------------------------------------------------------FQGLYQLTVAIILMSRVCKMFRQGLRGFREYQIIEPAQKKHPTFSFWDKKKQGRISFDTQDFAAEEGHFPPRAISITQKKPSWRTDEEIQDLCNILQVLDCYRNYTEYLQLLLAKVMRFERFGRRRVIVKKGQRGNSFYFIYLGTVAVTED--EDGSSAFLDPHPTLLHKGGFFGEMGLLSTAVRRATVVCMEETEFLVVDREDFLANKLGDEVQKETQYRYDFFRKLDMFQSWSDEKLWQLVALGRIEKFP-HGELVSKDIGNSAFITFICKKSKLRHKNIAVYGHGVEWRGQGSTELCLTPKPFWRTGTGIDPQVTKDIWCIFAKPMLVQGALCYRSRQRTYATDKHVGKPREASREAESHPVTDGLRDAKGNSAFSCIHQILVVWEGGLARKEVTQLQKQLTTAVSMFRPQMRLGSSVLHCGKKEVWLDPNETNGNAHANSRQRVRKLTKDGLIIWKPMTVHSGAHCQKSTLALGKGRHMGIGKRKGTANARMPEKGNCEILRMVDLGTCRTYYRWVWQQLELLDHKPLRVHN-------NEMSPKERFKEFQIKSYPLQDFTYLKLLRLQEAREQPAMTFHRKINKAENSLPKLLGPKVKSRYGHSVKCSMVHTKYGELPKEAIVGVYMKVHLTEEGDVVASWGKGTNKNSPCTLPRQYSDSGELGESSAGKMLATSLSTGNLSQSPGEKAGVVVLSMQRWGNHQAFLPEIHRDPRSFILLSLGTELIRVR-------------------------KEKFYDLVD--AETKAK-----------IMKMDVDYPSDEELCQSFLSENDWSIFRRDLLRLLVEP---LKKKPFIPIQTKKKEIYNPKSLLLDLCSLDKKVKVGGEPNGRWECMAIAMATGDQTSELSLTVSSIKSHQQLICSAGGQASISAHPTIFSNDPADVHIKSPSPVSCDTGTCHSDDTLSQLFRRQPCYELTEYTECVSLRQRFRLATGDCRVPASLGWKEDPRPNNRSFLSPLFGALSPSSSPIEASVHPVLSARSGSDPSLGWPSVLAQTRRLRPQKPRRASLGCQVVAILPAMPCSPPPGDVLEGLAGASPWPDLDSRGPVE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D5U8-1", "uniprot_id": "CNBD2_MOUSE", "id": "Q9D5U8-1", "name": "Cyclic nucleotide-binding domain-containing protein 2", "aln": "MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWTAKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRISFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITED--EDGSSAFLDPHPTLLHRGGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALGRIERFS-YGQMVSKDFMNSAFITFICQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNCEILRLVALGDCSAYYKWVWQQLELLDHKPLRIHD-------NEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQGIDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTEEGEIVG-------------------------------------------------------------LHQAFVPEIQRDCRPFILLSLGSELIQVR-------------------------KEKFYDMVD--EETRAK-----------IIKMDVDYPSDEDLCQSFLKENDYIVFRKDLLRLLVEP---LNKSPFIPVQTKKKEIYNHKSLFLDLCSLEKKVKQ-------------------------------------------------HYPIFLAP-------------------------------------------------------------------------QKYLPPLR----------------VVQAIS------------APRHKIQELLPQYKNAGVLI------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96M20-1", "uniprot_id": "CNBD2_HUMAN", "id": "Q96M20-1", "name": "Cyclic nucleotide-binding domain-containing protein 2", "aln": "------------------------------------------------------------------------------------------MRRHMVTYAWQLLKKELGLYQLAMDIIIMIRVCKMFRQGLRGFREYQIIETAHWKHPIFSFWDKKMQSRVTFDTMDFIAEEGHFPPKAIQIMQKKPSWRTEDEIQAVCNILQVLDSYRNYAEPLQLLLAKVMRFERFGRRRVIIKKGQKGNSFYFIYLGTVAITKD--EDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTIVCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWSDEKLWQLVAMAKIERFS-YGQLISKDFGESPFIMFISK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHL-------SEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILG-------------------------------------------------------------LHQAFLPEGECDTRPLILMSLGNELIRIR-------------------------KEIFYELIDNDDEMIKK-----------LLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEP---CQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKP-------------------------------------------------RYPIFMAP-------------------------------------------------------------------------QKYLPPLR----------------IVQAIK------------APRYKIRELLA---------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VXK3-1", "uniprot_id": "Q9VXK3_DROME", "id": "Q9VXK3-1", "name": "Cyclic nucleotide-binding domain-containing protein", "aln": "---------------------------------------------------------------------------------------------------------MSKRQRDVHDGAGKKIAKIRFKKLIRSVILNMQWLSELPEEGGISLNVKKNV-----AMLRQKRKVGMMTMAEKSLLRTPHAKRSVDERKKLCTIVANLACFSKFPPKVRARLVPIVKFMAISPGRIVMKEEDFPVTIYFIIAGEVEMSKNIYKKGSSRPTVQTEAIFGPGDCIGDIDVMEDTPRTNTYIATTYCELLAIFNTNYKI-VLLPFMQKMWQEKKDALRALDYFDFLNEEQIVNASKYGTIQQFEPLETIYTEDLGTMSYVYFVLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GECVVLQCLHMKVNMVNREKVFQLPNIYNLKTGPLLD-------DDTGPNDNEPLFDINEYVQSTSSLDENE---QSKKRKLRKMGLQEIQRLCDEIKKPVS-RRSTKESARQRLRLRQRGRDAERQITRKHYEFYLMGMGGESGN-------------------------------------------------------------ISEDLSEELYSDTSDMPTISTVASAEFE-----------------SE----SEGSEIFTASSTS-EQGNVEETVS--QEGFETHFIDVGSLTFGGIFGLGEKMEHRVIMARTTVQCIVIPRFWLFEPAQNPGNFWQRQRFYIECNIPTREDLFKDFIKTR-----------------------------------------------KWERFRRD---------------------------------------------------------------------------YISSILN-------------NESLANFTKH----------EDIPIISHIVETKSDDN---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VXJ8-1", "uniprot_id": "Q9VXJ8_DROME", "id": "Q9VXJ8-1", "name": "Cyclic nucleotide-binding domain-containing protein", "aln": "--------------------------------------------------------------------------------------------------------MAAKRNRDADIVKHKLDLRVRFKKLVRAVIMNQTWLSDE-EEQGISMNVKKNV-----ALMRQKRKPGMLTVADKALLRSNPAYRTIEERKKLCILIAGLNCFSRIPPKIRARMVPVLKFMSINEPRVIIKNGDMPISVYFILNGEVEMKKNTNNKAVKLEDAVAEAIFGPGDCFGDVEMVEECPRMNTYLALSSCEVLSIYDIDYER-ILKPHMLKQWNEKKLALKAFDYFDFLTPDQIILACKYSYLVQYEPLETIYMGDTDSLGYVRFVLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GECVILQCLSMKVTNTEGEVNYELTEINKDDGLEMFQ-------SWKDVTSRNSFLDIQDILASSTSSEEVEGG-TKKKQAMRKMGLAEIQKFCGLRTSNTP-SRKKTKPRRTLSTAAQARKTQLIQSLRRGTPWMPSVMPNDDDDDDDDDDGH----------------------------------------------IDEDYMGYGEDLYDEVDTDDSSYDSNSSSSSVSMDRTLVQVQLKPHSAGSSPSEKKVSSSSSEIFTASSVINEKSLVDESPKPIKEPVETHFIDVGSLTYGSVFGLGEKMEHRVIMARTVVQCLLLPRFWLLEEEQNPGNIWHRRRFYFECNVPSRQDLFTNFLKTR-----------------------------------------------QWNKFRHD---------------------------------------------------------------------------YIESLLD-------------REEKGNITKE----------EDIPIMCRIVETSDDAT---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4KGS5-1", "uniprot_id": "A0A0B4KGS5_DROME", "id": "A0A0B4KGS5-1", "name": "Cyclic nucleotide-binding domain-containing protein", "aln": "---------------------------------------------------------------------------------------------------------MQRRTKNTADTKRIQSLKALFKKVVRLMSLNDPWRENE-DDPRITSNVMKNLS----ARVRTKSKSGFLTAADKSLIRTPHVIRTIPERMKLCKLFAKLTCLAGFSPKIRARLVPVVRLMPVDAGRIIIRQSDAPITVFFVLTGEVHMIKNEKNQ---KGEGVVMGFLGAGDMMGDVELLEGIKRTHTFRAATYCELLVLFDYDFAP-ILGAYMTKIWEEKKRALKALDYFDFLDDDQIVEACRYGRLKQFDPLDTIFCEDIGSMTNVHFVLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GECLILQCLNIKVTMKRGKKVYDLLPASEGDVSKMFRKAVRSTFSSQSTNEDQSKIDILDLVASTSSSSTGDAQKSALNRKMRKMDLRDIEKRCGMIKSPPQKSRFTWRRSIRKSTMSVFSHSENRLISEDVFEDFWEMYENESDIES----------------------------------------------------------YSSGSDYTDVEFKQSFRFGPALNNTAELD-----------------------YDGSSIFSSSLSSFSSSSGSCTPT-----FESHFIDVGTITFGGIFGLGEKMENRVIMARSTVQCLILPRFFLLEKKQNPGNVWERRLLYVGVMVPSREALFAHYRKAC-----------------------------------------------DWKKFKND---------------------------------------------------------------------------LISETLK-------------PSD-NDITHI----------EDVPIICRIVESPEDLN---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . *:: :* . .. :: * : * :. : :. *: * :* :. * . . :: :. :::: .. *::::: : :.:*: * * : :: :. :: *. :*:: :: * * . *.* : :: * : * : : :: :: * ::: . : :: : * : *: . *.* :*: : : . :: . . . . ::* . . : : . : .: : . : .. * . . ::: : : . : :: : :: :: * . * . .:. . : * : . : ", "identical_positions": 31, "similar_positions": 131, "identity": "2.59%" }, { "cls_id": "homologset.agr.HGNC:16147", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZVK1-1", "uniprot_id": "MCM8_RAT", "id": "D3ZVK1-1", "name": "DNA helicase MCM8", "aln": "----------MSGAYRGRGFGRGRFQN----WKRG---RGGGNFSG---------------RWRDR---TDLSKAAGNHASEQASQP-----LLQ-------QSTLDQFIPYKGWKLYFS-EVYSNNSPLTEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTKDNEITNLIPDIENALRDAPEKTLACMGLAIHQVLT-KDLERHAAELQAQEGLCNGGGTMVNVPHIYARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTKMAFQCAACGEIQSFPLPDGKYNLPTKCPVPACRGR-SFTPLRSSPLTVTMDWQLIKIQELMSDAQREAGR-IPRTIECELVHDLVDSCVPGDTVTVTGIVKVSNSEEGSRSKNDKCMFLLYIEANSVSNSKGQKAQTAEDGCKHGTLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLMLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTATSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVSRVLSQDSNTSVLEVV-----------------------SEKPLSERLKVAPGE-KTDPIPHQLLRKYIGYARQYVHPRLSTEAAQALQDFYLELRKQS--QRVGSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSG--MSNRSTAKRFISALNSIAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQTM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CWV1-1", "uniprot_id": "MCM8_MOUSE", "id": "Q9CWV1-1", "name": "DNA helicase MCM8", "aln": "----------MSGAYRGRGFGRGRFQS----WKRG---RGGGNFSG---------------RWRERENRVDLNEASGKHASAQASQP-----LLQ-------QSTLDQFIPYKGWKLYFS-EVYSNNSPFIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACMGLAIHQVLT-KDLERHAAELQAQEGLSNGGETMVNVPHIYARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYTLPTKCPVPACRGR-SFAPLRSSPLTVTLDWQLIKIQELMSDAQREAGR-IPRTIECELVHDLVDSCVPGDTVTVTGIVKVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQKAVSSATVTRVLSQDSNTSVLEVV-----------------------SEKPLSERLKVAPGE-QTDPIPHQLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQS--QRVGSSPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDEFGNLDFERSQHGSG--MSNRSTAKRFISALNSIAERTYNNIFQYHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKIYQLQTM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJA3-1", "uniprot_id": "MCM8_HUMAN", "id": "Q9UJA3-1", "name": "DNA helicase MCM8", "aln": "----------MNGEYRGRGFGRGRFQS----WKRG---RGGGNFSG---------------KWREREHRPDLSKTTGKRTSEQTPQF-----LLSTKTPQSMQSTLDRFIPYKGWKLYFS-EVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLT-KDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGR-SFTALRSSPLTVTMDWQSIKIQELMSDDQREAGR-IPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVV-----------------------SEKPLSERLKVVPGE-TIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQS--QRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSG--MSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F643-1", "uniprot_id": "E7F643_DANRE", "id": "E7F643-1", "name": "DNA helicase MCM8", "aln": "----------MSSQGSSRGSWRGGNSSGSGGWRGGGGWRGGRGWSNGQYR-----------GWRGRQWSGGGGGGRGNYSNNNTQKGN----APQVSQARVTQATLDITCPYKGWRLYFS-EGFVESSPYVEKIKVFEQYFTSQIDLYDKDEIERKGSILVDYKDLLSNKQVSHSLPDLARDLKEMPEKILDCLGVAIHQVLT-LDLERHAAELQGQEELPAGIRPIINIPHISARLYNYEPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDGKYTMPTKCLQSECRGR-SFTPNRSSPFTLTVDWQTIKVQELMSGDQRESGR-IPRTIECELTQDLVDSCVPGDMVTITGVIKVSNEEGSTRNKKDKCMFLLYIQANSVSNSKGQKSKAVSESEGQGPSVEFSIKDLYAIQEIQAQEDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGDPHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQGICCIDEFDKMGSQHQALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAGKSGAVSGAAATRFNTHESSISILEVS-----------------------SEKPLADTLKLVPGE-AFDPIPHQLLRKYVGYARHYVHPTLSAEAAQVLQDFYLELRKQN--QTADSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIMKHSLTDTYSDEFGRLDFDRSQLGSG--MSNRSKVKKFVSALNKLAERTSKSMFELQDLRQLAKDLQIQVVDFEGFICALNEQGYLLKKGHRMYQLQTI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VF30-1", "uniprot_id": "MCMR_DROME", "id": "Q9VF30-1", "name": "DNA replication licensing factor REC", "aln": "MNPTLSRGGAPSRFVRGRGRGGGAYRPYFYFRRNGRVIPAGGNRQPNQGEPGAPDAPSVPPATRQPRGWSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKR-------------EFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEAIN---------VLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTG-FSQLVEMANLGGYLLMKGANMYEVVPD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .** * : * .* . . * *. : : . ::* .*.**:*** * : :.. :* ..* :: : . :* *. :* : : : . ::.. *.: ::: * : * :.:*:* *:. :*: : : . . .: :* ** :: *: ::.: . .. . :** * .*.: . ** * * :. . * :* . * .* .*.. **** * * *:::* . :: :* :: ** :****: *: *.:**::*:.: .: . . . : *::* *: ::.. * *** :** ** *:*: : :**:*:*:.* ::** * **. *:*:** .: * :*:*****:**:::**: .::* **.:*.*: : *. : :: . . .. :: .. * * :*:.**:..:: .**:.::.:.:.*. ** ..::**:.*:**.*** *:*::.: : :*:::..:** .*.**:****.*.* :* *: ** *::** *: . .: *. .: * . *:: * * * :* *::*::.***: : * *. :*:..: ::***: . : *: * : ** ::*:*::****::* . .: ....*:: ::. *: * .* . : *. *:* .: : :.*:. : : . :*: .:*:::.. * . *. :: * **** ** .:*:: . ", "identical_positions": 197, "similar_positions": 291, "identity": "21.67%" }, { "cls_id": "homologset.agr.HGNC:16148", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U2V5-1", "uniprot_id": "CRLS1_RAT", "id": "Q5U2V5-1", "name": "Cardiolipin synthase (CMP-forming)", "aln": "MLAWRVARGAWGSLRVAVRPPGARLGRGGS------RRALLPPAACCLGCLAERWRLRPAAFALRLPGTSPRTHCSGAGKAAPEPAAGG-------------DAAAQAPSARWVRASATSSYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQKSALGSALDPLADKVLISILYISLTYAD---LIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPR----TLAKYFNPC-YATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCCTAFTTAASAYSYYHYGRKTVQVIKGK-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80ZM8-1", "uniprot_id": "CRLS1_MOUSE", "id": "Q80ZM8-1", "name": "Cardiolipin synthase (CMP-forming)", "aln": "MLAWRVARGAWGPLRVALRPPGARLGRGGS------RRALLPPAACCLGCLAERWRLRPAAFALRLPGAGPRTHCSGAGKAAPEPAAGGG------------GAAAQAPSARWVPASAASSYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQKSALGSALDPLADKVLISILYISLTYAD---LIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPR----TLAKYFNPC-YATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCCTAFTTAASAYSYYHYGRKTVQVIKGK-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJA2-1", "uniprot_id": "CRLS1_HUMAN", "id": "Q9UJA2-1", "name": "Cardiolipin synthase (CMP-forming)", "aln": "MLALRVARGSWGALRGAAWAPGTRPSKRRA------CWALLPPVPCCLGCLAERWRLRPAALGLRLPGIGQRNHCSGAGKAAPRPAAGA-------------GAAAEAPGGQWGPASTPSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNWANQRSALGSALDPLADKILISILYVSLTYAD---LIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPR----TLAKYFNPC-YATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCFTAFTTAASAYSYYHYGRKTVQVIKD--------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8MZC4-1", "uniprot_id": "CRLS1_DROME", "id": "Q8MZC4-1", "name": "Probable cardiolipin synthase (CMP-forming)", "aln": "MLPAIIFRQVQRPLHHGAATLEHVLGVGGSSFVNCLNRYAAATGFIRISFLDIKRRRNYELARLRLYADEKKQSLHLRTLQGRHLLQGVIERKNFLVDDIREARHKVQERVREKIDEIREERENIMTIPNMLTISRAVLSPYIGYVIVQGDFTLGMSLLAFAGITDLLDGQIARRWPSQASKFGSFLDPMADKLLMGSLVISLCYTD---LLPMWLMGIVVFRDVFLLGAGFVIRYISLPPPK----TFSRYFDAT-HVTAQLEPTLLSKINTGVQLATIGLSLGAPIWNYLDHPALQGLWYLTGLTTAATALSYVMNRHNTFKIIQKKT------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07560-1", "uniprot_id": "CRLS1_YEAST", "id": "Q07560-1", "name": "Cardiolipin synthase (CMP-forming)", "aln": "MIQMVPIYSCSALLRRTIPK---------------------RPFYHVLSGLTVRFKVNPQLNYNLFRDLTRREYATNP-------------------------------------SKTPHIKSKLLNIPNILTLSRIGCTPFIGLFIITNNLTPALGLFAFSSITDFMDGYIARKYG-LKTIAGTILDPLADKLLMITTTLALSVPSGPQIIPVSIAAIILGRDVLLAISALFIRYSTLKLKYPGRVAWNSYWDIVRYPSAEVRPSQLSKWNTFFQMVYLGSGVLLLLYEKEEGCEKTEEDFEDRKQDFQKAFSYLGYVTATTTIMSGVSYALKRNAFKLLK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: *: . :. * : : . : : . .: .***:*:::* :* :* .*: ::. .:.::*::.:**::** ***.: : *: ***:***:*: ::* .. ::*: : ::: ***:* : : :** :* : *:: : :*.:.*: :** ** .*: :. .: ::: : .* ** * ::. ", "identical_positions": 48, "similar_positions": 83, "identity": "14.04%" }, { "cls_id": "homologset.agr.HGNC:1615", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIM9-1", "uniprot_id": "TCPB_RAT", "id": "Q5XIM9-1", "name": "T-complex protein 1 subunit beta", "aln": "MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDA-SLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAK-KIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTMLASRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P80314-1", "uniprot_id": "TCPB_MOUSE", "id": "P80314-1", "name": "T-complex protein 1 subunit beta", "aln": "MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDA-ALMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAK-KIHPQTIISGWREATKAAREALLSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P78371-1", "uniprot_id": "TCPB_HUMAN", "id": "P78371-1", "name": "T-complex protein 1 subunit beta", "aln": "MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDA-SLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAK-KIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W392-1", "uniprot_id": "Q9W392_DROME", "id": "Q9W392-1", "name": "T-complex protein 1 subunit beta", "aln": "-MEMSLNPVRVLKNEAQEEKAEMARLSSFIGAIAIGDLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQ-KLHPQIIVSGWRQATQVALEALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLKGSGELKSIQIIKKSGGTLGDSFLDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCTGGEIVSTFENPSLVKLGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQQILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLSLPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEAAEMILRVDNIIRCAPRRRVPDRGYC", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39076-1", "uniprot_id": "TCPB_YEAST", "id": "P39076-1", "name": "T-complex protein 1 subunit beta", "aln": "------MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNT--CMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .*.:: . **:** ***::*:****:***************:* ::. :: *********: : :******:**::*:***:************::*******.*: : *:*** *: *:* *: .* :** :* *:. .. * :**::** ******:* :.**.*::**.:*::***** :*: *::** **.*.**:*****:* ** * :**:*****:****** :****:*:**: .:*** **:*::* **:****:*: :* *. * ********:****** : :****** *:**** ****:.***:.*. ***.*.:**::*:**: :::*** *******:****:* ****:*******.**: *.*:.* : ****:* :*: ** * . **:::*:*::*:** *** :*****:**::**::**:. :* * ***:. *.:.*: ***.**: :** *: **:****::*******:. ** :: ", "identical_positions": 294, "similar_positions": 143, "identity": "54.75%" }, { "cls_id": "homologset.agr.HGNC:16153", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZSU2-1", "uniprot_id": "A0A8I5ZSU2_RAT", "id": "A0A8I5ZSU2-1", "name": "", "aln": "MEYEAKKGKKGFVSPIRRLVFPKAARQAAFKSNVSRRPLHSMPLYPPDYLIDPHILLCDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTPEQDSILSLSARCLLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGLGVDPVPAGMDGSPGSSGRDPGPPGAAPEKRRVGTAERRHTICSLDWRMAWGGGAGAEARAAGGGGSLERQRAGARASGSWERRQTFSGSWERRHAGGG----AGKPGGSWERRQASGGVGGSWERRHPGPNPLDPQNHSPDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYRPTPKRPWLSSCSESCRTDGTFAYDADLSCCSSFNGSQDTFEACYSGASTPSFHSSHCSSIDHSSWAFEQLQDYMVTLRSKLGPPEIQQFAMLLRDYRLGLPIQDYCAGLQKLYGDRRKFLLIGMRPFIPDQDIGYFEGFLESMGIREGGILTDSFGRIKRSMSSTSASAVRSYDGAAQRPEEQTFHQLLTDITHDIEALAPDDDDVYED---VSPSGGDQVEDNYL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NUG4-1", "uniprot_id": "CCM2L_HUMAN", "id": "Q9NUG4-1", "name": "Cerebral cavernous malformations 2 protein-like", "aln": "MEYEVKKGKKGFVSPIRRLVFPKAGRRAACRSSVSRRPLHSMPLYPPDYLIDPQILLCDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTAEQDSILSLSARCLLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGLGVDPVPAGVDASPGGAGRDPGPPGGAPEKRRVGTAERRHTICSLDWRMGWGGGAAEARAGGGGGGSLERQRAGARASGSWERRQTFSGSWERRHGGGGGGGGAGKPGGSWERRQAGSGGGGSWERRHPGPNPLDPQDPSPDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYTSTPERPWLCSRSESCHTDGTYAYDADFSCCSSFNGSQDTFEACYSGTSTPSFHGSHCSGSDHSSLGLEQLQDYMVTLRSKLGPLEIQQFAMLLREYRLGLPIQDYCTGLLKLYGDRRKFLLLGMRPFIPDQDIGYFEGFLEGVGIREGGILTDSFGRIKRSMSSTSASAVRSYDGAAQRPEAQAFHRLLADITHDIEALAPDDDDDDEDEPRGSRGGSDAAEDNYL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8VCC6-1", "uniprot_id": "CCM2L_MOUSE", "id": "Q8VCC6-1", "name": "Cerebral cavernous malformations 2 protein-like", "aln": "MEYEAKKGKKGFVSPIRRLVFPKAARQAAFRSSVSRRPLHSMPLYPPDYLIDPHILLCDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTPEQDSILSLSARCLLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGLGVDPVPAGMDGSPGGSGRDPGPPGAAPEKRRVGTAERRHTICSLDWRVAWGGGAGAEARAAGGGGSLERQRAGARASGSWERRQTFSGSWERRHAGGG----AGKPGGSWERRQASGGVGGSWERRHPGPNPLDPQNHSPDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYRSTPKRPWLSSCTMAPRTHLKRATVAHPHRLS---------TAPTAAVSTTAAGPSSSYRITWSRCGVS---------------------WVLLRSSSL------HCCYETIVWG------------------------CLSRTTVQ---VCRNSMGTDGSSFSLECGPSSQIRTSATSRASWRVWVSARAESS--LTALAASSAA---------------------", "tax_id": 10090, "tax_name": "Mouse" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****.*******************.*:** :*.********************:**************************************************.************************************************************:*.***.:********.**********************:.*****. ..*********************************.*** *************..* *****************: ************************************************* .**:****.* : : :*. . * *. * * :..**.: * . * ... :***. * :* ::* *. :: : :*:* *:* ...: : .*:.*.. :.: :: : : ***... ", "identical_positions": 344, "similar_positions": 71, "identity": "60.25%" }, { "cls_id": "homologset.agr.HGNC:16154", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q969T3-1", "uniprot_id": "SNX21_HUMAN", "id": "Q969T3-1", "name": "Sorting nexin-21", "aln": "MHRGTQEGAMASRLLHRLRHALAGDGPGEAAASPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDEDDEDEDDEEAGPDQLPLGDGTSGEDAERSPPPDGQWGSQLLARQLQDFWKKSRNTLAPQRLLFEVTSANVVKDPPSKYVLYTLAVIGPGP-PDCQPAQISRRYSDFERLHRNLQRQFRGPMAAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRHAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQAQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACCEKALQ---LLGDKSLHPLLAPFLEAHVRLSWRLGLDKRQSEARLQALQEAGLTPTPPPSLKELLIKEVLD----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q3UR97-1", "uniprot_id": "SNX21_MOUSE", "id": "Q3UR97-1", "name": "Sorting nexin-21", "aln": "---------MASRLLHRLRHALASDGPGEAAAGPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDPDDEDEDDE-AGLDSPPSGDGASGEDAERSPPPDGQRSSQLLARQLQDFWKKSRNTLVPQRLLFEVTSANVVKDPPSKYVLYTLAVMGPGP-PDRQPAQISRRYSDFERLHRNLQRQFRGPMSAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRQAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQTQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACSEKALQ---LLGDKRPHPFLAPFLEAHVRLSWRLGLDKRQSEAQLQALQEAGLTSTPPPSLKELLIKEVLD----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VQG1-1", "uniprot_id": "Q9VQG1_DROME", "id": "Q9VQG1-1", "name": "", "aln": "-------MPIHAVMAKRLHHQPTFDGDP-----------PGPDELDSPAIEAAALDIP------PPESDK-------------ALQKGVWERATSAEYKPTTDG------------------STVLRFDILLAHIMPPDGEDVKIKRFVVYELTVKQDGATEDTQPAKIERRYTDFRELYLGLKRQHPAEMANKYFPAKVLMGNFKSELIGERSAAFEAFLTYVASQAMLRDSEYFLRFLQHDELTRACQFLDERRNEMAIPILENCFRLLNKIYMNRSRPVLLILCRLVAACTSSPVPHHAAERWALLALSRFETLCDIDLLPLYIPLLHTCAHLWWQRGQDQKPITDRLTDMSKQGINTANTESLMQAIHKIDPRTETI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : :**:* : ** * ..**:. *. : :. ..*.* * . .** .*..** ..* : ** .: ..: . .::*:* *:* *. * ***:*.***:**..*: .*:**. . *: ** * * **.:* *..** *** ** :: : . **.: : *: ** ** .: . *:.: *.::* :: . *: :*.* .. *. . **. * * *: *:*.: .:* *: * *:: :* :.: *:..: . ** : : * ", "identical_positions": 85, "similar_positions": 100, "identity": "22.31%" }, { "cls_id": "homologset.agr.HGNC:16155", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ABM7-1", "uniprot_id": "D4ABM7_RAT", "id": "D4ABM7-1", "name": "", "aln": "-----------------------------MALTMLNGLLIKDSSPPML-HQISKTPQLDAFNYQSCFMQDLFAHFPDVLFIHRTYNPRGKVLYTFLVDGPRVQVEGPLARAVYFAIPTNEDARGLAQMFQVFKKFNPAWERITTILVDPHFLLLPTLTMEFPAAEVLLSAFHICKFLQGKFYQLSLEQPVQSVLLSSLQSTMCSATAGNLRKLYTLLNTCIPPSRLPELHSHWLLNDRIWLAHRWRSRAQSNRYFQTLEVTAHVLSQFFGATPFEKQGMASVFRYMQQNPSDKANLSLVESPQDSQPPSDASPENPNTEQLVEARIQHSLNAICTGPAAQLCLGELAVVQKSMHLIGSGSEKMNIQILEDTHNVQPQSPASCSCYFNQAFHLPCRHILAMLSARQQVLQPDMLQTQWTSGCATSLDSILGSKWSASLDKHLAVTLLTEEVGRLLEHCSKEEFERRYSTLRELADSWIGPYEQVQL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CWV7-1", "uniprot_id": "ZSWM1_MOUSE", "id": "Q9CWV7-1", "name": "Zinc finger SWIM domain-containing protein 1", "aln": "-----------------------------MALTMLNGLLIKDSSPPML-HQISKTPQLDAFNYQSCFMQDLFAHFPEVLFIHRTYNPRGKVLYTFLVDGPRVQVEGPLARAVYFAIPTNEDARGLAQMFQVFKKFNPAWERVNTILVDPHFLLLPTLTMEFPTAEVLLSAFHICKFLQGKFYQLPLEQPVQRLLLSSLQSTMCSATAGNLRKLYTLLNNCIPSSRLPELHSHWLLNDRIWLAHRWRSRAQSSRYFQSLEIMAHILSQFFGTTPFEKQGMASVFRYMQQNSSDKASLSLAETPQDSHTPSEASAENPNTEQLVEARIQHSLNAICTGPAAQLCLGELAVVQKSMHLIGSGSEKMSIQILEDTHTVQPQPPASCSCYFNQAFHLPCRHILAMLSARQQVLQPDMLPAQWTSGCASSLDSILGSKWSASLDKHLAVTLLTEEVGRLLQHCSEEEFERRYSTLRELADNWIGPYEQVQL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BR11-1", "uniprot_id": "ZSWM1_HUMAN", "id": "Q9BR11-1", "name": "Zinc finger SWIM domain-containing protein 1", "aln": "MLERLKAPWSAALQRKYFDLGIWTAPISPMALTMLNGLLIKDSSPPMLLHQVNKTAQLDTFNYQSCFMQSVFDHFPEILFIHRTYNPRGKVLYTFLVDGPRVQLEGHLARAVYFAIPAKEDTEGLAQMFQVFKKFNPAWERVCTILVDPHFLPLPILAMEFPTAEVLLSAFHICKFLQAKFYQLSLERPVERLLLTSLQSTMCSATAGNLRKLYTLLSNCIPPAKLPELHSHWLLNDRIWLAHRWRSRAESSHYFQSLEVTTHILSQFFGTTPSEKQGMASLFRYMQQNSADKANFNQGLCAQNNHAPSDTIPESPKLEQLVESHIQHSLNAICTGPAAQLCLGELAVVQKSTHLIGSGSEKMNIQILEDTHKVQPQPPASCSCYFNQAFHLPCRHILAMLSARRQVLQPDMLPAQWTAGCATSLDSILGSKWSETLDKHLAVTHLTEEVGQLLQHCTKEEFERRYSTLRELADSWIGPYEQVQL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ******************* **:.**.***:*********.:* ***::*************************:** **********::**:.******************: ********* ** *:****:***************.*****.**:**: :**:*********************..***.::************************:*.:***:**: :*:******:** *******:*******.:***.:. .*:.:.**:: .*.*: *****::*************************** **********.********.****.**************************:******** :***:***:*********** :******** ******:**:**::***************.**********", "identical_positions": 371, "similar_positions": 66, "identity": "76.49%" }, { "cls_id": "homologset.agr.HGNC:16156", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABZ3NNJ5-1", "uniprot_id": "A0ABZ3NNJ5_RAT", "id": "A0ABZ3NNJ5-1", "name": "", "aln": "------MAAPSKPVGLGGPR-----SPACPEPPP----------------------------TRFHQVHGANIRMDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDP----ASLASVPEFSLPDLVSLGHSWVFAITRHHNRVPREGQTEAEAAVPSGPQTLLVEPYLRIQQFRIPRDRLVGRSRPGLYSHLLDQLYEQNVLPPTARRSRLGVLFCP--REDGTADMHIIINGEDMGPSARGLPA-AQPLYAVVDVFASTKSVRLVQLEYGSFCLHVCTCRPEEGTRPDCEPPCGCWELNSGPLEEQSVLLTSEPSLQPQPKPIFDPRLLENLTHLLLVF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D0S4-1", "uniprot_id": "NEUL2_MOUSE", "id": "Q9D0S4-1", "name": "Neuralized-like protein 2", "aln": "------MADPSEHVGLGGPR-----SPARPEPPP----------------------------TRFHQVHGANIRMDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDP----ASLAAVPEFSLPDLVSLGHSWVFAITRHHNRVPREGQPEAEAAVPSGPQALLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYEQNVLPPTARRSRLGVLFCP--REDGTADMHIIINGEDMGPSARGLPA-AQPLYAVVDVFASTKSVRLVQLEYG---------------LPSLQTLCR-------LVIHKRVVHRLAIDVLHLPKGLKDFCKYE---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BR09-1", "uniprot_id": "NEUL2_HUMAN", "id": "Q9BR09-1", "name": "Neuralized-like protein 2", "aln": "------MAAASEPVDSGALW-----GLERPEPPP----------------------------TRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDP----ASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCP--RPDGTADMHIIINGEDMGPSARGLPA-AQPLYAVVDVFASTKSVRLVQLEYG---------------LPSLQTLCR-------LVIQRSMVHRLAIDGLHLPKELKDFCKYE---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W112-1", "uniprot_id": "Q9W112_DROME", "id": "Q9W112-1", "name": "Neuralized-like protein 2", "aln": "MEAAEQLDEAAAPAALCAPSRAAYAAAEQEDPDPDQEQDRGRESPIGSLECAPTLSSRKRQLSRFHPYHGSNIQLGDDATVAYRRASFADALTFSERPLAPGDIFLVEIEKIERGWSGHMRLGLTELAPNVIRTSSEGLPHFALPDLANLGNSWIYPISKFEMNQRQDANDIIEPETDDAPHRNLLG---DATHVRTPRGLLPKR----LLRPAMGNGNDSDILL-TDKGSRIGIIYVPTVQSDSKGELHFIINGVDRGPVSRDIPLNRAPLFVVIDVYGTTKQIRIIQLEGI----------------LSLQSACR--------NVILESFAEDAISELPLPESIKRFLLRRD--------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: . . . :* * :*** **:**::. ..* * * ***..: **..*****::******: * **.**:***** * * :* :*.*:****..**::*::.*::.. . ::.. *. . . * *: :.* **. * * * :.: : ::* * : **:*::: * : *...::*:**** * ** :*.:* **:.*:**:.:**.:*::*** . :. * . . *: : . ", "identical_positions": 90, "similar_positions": 90, "identity": "24.86%" }, { "cls_id": "homologset.agr.HGNC:16157", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AC07-1", "uniprot_id": "D4AC07_RAT", "id": "D4AC07-1", "name": "", "aln": "MELGSCFKTYEDFKECFSAYKKETRCSFIVRDCVSVRFHNLNNGTSFREDILYVQVKFVCIRTQSNRKKTRKVDRCPAYLLLQYNERLDRLFISELNTQHIHADSSAAAGG-VPASKPQKALCLHELQPVQLSIKKDLDTAEKPPVEPSFCLDKIHKPSNPEQEGISPSDMAKIAKVMKNFLTVDEGSMASFSVGTSQDLDRLSFQSSKMSDLFTRFPETLLLHRVENSQGHILYAFLVENKERESRVVHFAVLKAETAPSVAKMLNIFTEFNSDWPKVKVVFVDPSFPHRAILQEIFPAARTLLSIYHTTRLLEKKLHQSSVNASFKRLMKEALREAVFVSSDASLKNLCEMSQALLDEELFSFLQAHWFSCELLWYMHVRKGLHACNTYMDSLDIVTSKVSSLFREQRSLLDCILHFVDYIDFFNTKGLKSLPTNSPKLKRTRLPSTPPRPKKPFRICGGSATRLPVEEVEETKPDSAQSKSPQ-PQDQSSKGGMLDILHQSGSELAYKLCHNEWEVVQNSTHLVDEAGASVAVQLLENSHQVSKDGCSCSCSFQQCYHLPCRHILALLHTSQQPVGEAMVCCRWQKKYQHLLDPNGELQDRGIIPNTDEPEKQGQNHKIRDLSRELANLLMQTEGPELEERCSTLRKIVDIWADPYQRPESSQQQPVDFRDAGCLPFLWGKLETGDSPPPAEAMVHD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CFL8-1", "uniprot_id": "ZSWM3_MOUSE", "id": "Q8CFL8-1", "name": "Zinc finger SWIM domain-containing protein 3", "aln": "MELGSCFKTYEDFKECFSAYKKETRCSFIVRDCISVRFHNLNNGTSFREDILYVQVKFVCIRTQSNRKKTRKVDRCPAYLLLQYNETLDRLFISELNTQHIHADS-NASGG-IPASKPQ-AICLHKLPPVQLSIRKDLDTAEKPSVEPSFCLDKIHKPSNPEQEGISPSDMAKIAKVMKNFLTVDEGSMASFSVGTSQDLDRLSFQSSKMSDLFARFPETLLLHRVENSQGHILYAFLVENKERESRVVHFAVLKAETAPSVAKMLNIFTEFNSDWPKVKMVFVDPSFPHRAILQEIFPSARTLLSIYHTTRLLEKKLHQSSVNASFKRLMKEALREAVFVSSDASLKNLCEMSQVLLDEELFSFLQAHWFSCELLWYIHVRKGLHACNTYMDSLDIVTSKVSSLFREQRSLLDCILHFVDYIDFFNTKGLKSLPTNAPKLRRTRLPSTPPRPKKPFRICGGGDTRLPVEEVEETKADSAQSQLPQ-PQDQSSKAGMLDILHQSGSELAYKLCHNEWEVVQNSTHLVDEAGSSVAVQLLENSHQVSKDGCSCSCSFQQCYHLPCRHILALLHTSQQPVGEAMVCCRWQKKYQHLLDPNGELQDRGIIPNTDQPEKQGQNHMIRDLSRELANLLMQTEGPELEERCSTLRKIVDIWADPYQLPESSQQ-PVDFRDVGCLPFLWGKLEEADSPPLAEAMVHD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96MP5-1", "uniprot_id": "ZSWM3_HUMAN", "id": "Q96MP5-1", "name": "Zinc finger SWIM domain-containing protein 3", "aln": "MELGSCFKTYEDFKECFSAYKRENRCSFILRDCVSVRFHNLNHGTSIREDILYVQVKFVCIRTQSNRKRTREADMCPAYLLLRYNERLDRLFISELNTQHIHGDSKVASPGGDTTGKSQKTMCLQRLQPVQPTTKKDLDTAEKSLVEPSFCLDKVQVSSKPEQEGITPSDLAKIAKVMKNFLKVDEGSMASFSVGDSQHLDRLSFQSSKMTDLFIRFPENLLLHRVENTQGHILYAFLVENKERESRVVHFAVLKAETVTSVAKMLSIFTEFNSDWPKVKVVFVDPSFHYRAILQEIFPAARILLSIYHTTRLLEKKLHRSSANPSFKRLMKEALREAVFVTSEASLKNLCQMSQAVLDEDLFNFLQAHWFTCELLWYMHVRKGLLACNTYMDSLDIVTSKVSSLFREQQSLLDCILCFVDYIDFFNTKGLKNLPTPPPKLKRARPASMPLKSKKAFGICGESLTSLP---AEETKPDAQQVQVQQQSQVPPSQVGMLDTLHQSGSELAYKLCHNEWEVVQNSTHLVDMAGSSVDVQLLEDSHQVSKDGCSCSCSFQQWYHLPCRHILALLHTSQQPVGEAMVCRRWQKKYQYLLGPNGELQDRGMVPNTGQPEKQGRNDMIQDLSRELANLLMQTEGPELEERYSTLRKIVDIWAGPSQPSELFQQ-PGDFKDVGRLPFLWGKQEEGEGFPPATAVMHY", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********************:*.*****:***:********:***:*********************:**:.* *******:*** ***************.** *: * .:.*.* ::**:.* *** : :********. *********:: .*:******:***:***********.************ **.***********:*** ****.********:*****************************..******.*************:******* :*********:** ****************:**.*.****************:*:*******:***.:***:**.*******:******:****** ***********************:******* **************.*** .***:*:* .* * :.**.* *** . * ** .****.*: * : * .* .*: **** **************************** **:** *****:***************** ************************* *******:**.*********::***.:*****:*. *:********************* ***********.* * .* ** * **:*.* ******* * .:. * * *::* ", "identical_positions": 553, "similar_positions": 89, "identity": "79.0%" }, { "cls_id": "homologset.agr.HGNC:16158", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DA57-1", "uniprot_id": "SPT25_MOUSE", "id": "Q9DA57-1", "name": "Spermatogenesis-associated protein 25", "aln": "MSYFVSPQSHLGLLPSGQGGAASSGSSLGLYSPAEPVVVAPGGLGPLSQKAEQVAPAAQAWGPTLAVPEARGCSGGVSWETPRRKEHNRYCPKLPPMRPLESLGWADPCSRSRAPYLGGPSRPRPLLLCGLSPGVLPISSEAGGKEAASQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGVQWEQAHAHAHMASGQMPLVRSRRG----SCL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BR10-1", "uniprot_id": "SPT25_HUMAN", "id": "Q9BR10-1", "name": "Spermatogenesis-associated protein 25", "aln": "MSYFRTPQTHPGPLPSGQGGAASPGLSLGLCSPVEPVVVASGGTGPLSQKAEQVAPAAQAWGPALAMPQARGCPGGTSWETLR-KEYSRNCHKFPHVRQLESLGWDNGYSRSRAPDLGGPSRPRPLMLCGLSPRVLPVPSEAVGKEASSQPDICILTLAMMIAGIPTVPVPGVREEDLIWAAQAFMMAHPEPEGAVEGARWEQAHAHT--ASGKMPLVRSKRGQPPGSCL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** :**:* * **********.* **** **.******.** *******************:**:*:****.**.**** * **:.* * *:* :* ****** : ****** **********:****** ***:.*** ****:************************:****** ******************.:*******: ***:******:** ***", "identical_positions": 180, "similar_positions": 25, "identity": "78.26%" }, { "cls_id": "homologset.agr.HGNC:1616", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6P502-1", "uniprot_id": "TCPG_RAT", "id": "Q6P502-1", "name": "T-complex protein 1 subunit gamma", "aln": "MMG-HRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLS-VAEHFLEQQMHPTVVISAYRMALDDMVSTLK-KISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTV------QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQEN---CETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P80318-1", "uniprot_id": "TCPG_MOUSE", "id": "P80318-1", "name": "T-complex protein 1 subunit gamma", "aln": "MMG-HRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLS-VAEHFLEQQMHPTVVISAYRMALDDMISTLK-KISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTV------QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQES---CETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P49368-1", "uniprot_id": "TCPG_HUMAN", "id": "P49368-1", "name": "T-complex protein 1 subunit gamma", "aln": "MMG-HRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLS-VAEHFLEQQMHPTVVISAYRKALDDMISTLK-KISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMV------QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQEN---CETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P48605-1", "uniprot_id": "TCPG_DROME", "id": "P48605-1", "name": "T-complex protein 1 subunit gamma", "aln": "MFGGQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLA-AAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETV------TLSENGRLEVDIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQ------VKGPYTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVSGSKKRGGNEPTNPAAMAQGQE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39077-1", "uniprot_id": "TCPG_YEAST", "id": "P39077-1", "name": "T-complex protein 1 subunit gamma", "aln": "---MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIK-QVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGN----FTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK---------------QE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *::.:. . :* :**:.* ** *.*::**:*******::*:***:*****:*:****:****** * *******:*::************:**:****:*: * ::::::**.::* * : ** * : :: ::* :*:.: * .::::.: ** : :**. ::*****: * .. : . *:***:*.:******* : :* **:**::****.**:* * *:***:****..**********::** *:*:.*:**:*** :: :* :*: ::* :*:****:********::.. :.:**::*:** ****. ** **.* *:* *.****..**:::: ******:*: :**:******:***.**:**.* :******: *.**::*.* * .**** ***.: *:.* : ** ***.*:* ***** **.*...** *: *****:. . : *::*:.* :*** .**** .:* *: ***:*:* ****:****** :* **", "identical_positions": 276, "similar_positions": 161, "identity": "49.55%" }, { "cls_id": "homologset.agr.HGNC:16160", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9H147-1", "uniprot_id": "TDIF1_HUMAN", "id": "Q9H147-1", "name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "aln": "-----------------------------------------------------------------MGATGDAEQPRGPSGAER-----GGLELGDAGAAGQLVLTNPWNIMIKHRQVQRRGRRSQMTT--SFTDPAISMDLLRAVLQPSINEEIQTVFNKYMK-FFQKAALNVRDNVG-EEVDAEQLIQEACRSCLEQAKLLFS--DGEKVIPRLTHELPGIKRGRQAEEEC-------AHRGSPLPKK---RKGRPPGHILSSDRAAAGMVWKPKSCEPIR-------------------------------------REGPKWDPARLNESTTFVLGSRANKALGMGG-TRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATG--GKMAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTEN-----------------------------------EHRAVEAPPQT---------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99LB0-1", "uniprot_id": "TDIF1_MOUSE", "id": "Q99LB0-1", "name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "aln": "-----------------------------------------------------------------MGATGDTEQPRGPGGAER-----GGLELGDAGAAGQPVLTNPWNIMIKHRQVQRRGRRSQMTT--SFTDPAISMDLLRAVLQPSINEEIQGVFNKYMK-FFQKAALNVRDNVG-EEVDAEQLIQEACRSCLEQAKLLFS--DGEKVIPRLAHELPGIKRGRQAEEE--------SHRGSPIPKK---RKGRPPGHVLSNDRAAAGMVWKQKSCEPIR-------------------------------------REGPKWDPARLNESTTFVLGSRANKALGMGG-TRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATG--GKMAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTEN-----------------------------------EHRAAEAPPQT---------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q91Y53-1", "uniprot_id": "TDIF1_RAT", "id": "Q91Y53-1", "name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "aln": "-----------------------------------------------------------------MGATGDTGGPR-PGTESR-----RPGNVGNAGAAGQPVLTNPWNIMIKPRQVQRRGRRSQMTT--SFTDPAISMDLLRAVLQPSINEEIQSVFNKYMK-FFQKAALNVRDNVG-EEVDAEQLIQEACRSCVEQAKLLFS--DGEKVIPRLAHELPGIKRGRQAEEE--------SHREAPFPKR---GKVGLPGHVLSNDRAAAGMVWKPKSCEPIR-------------------------------------REGPKWDPARLNESTTFVLGSRANKALGMGG-TRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATG--GKMAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTEN-----------------------------------EHRAAEATPQT---------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VZY7-1", "uniprot_id": "Q9VZY7_DROME", "id": "Q9VZY7-1", "name": "DNTTIP1 dimerisation domain-containing protein", "aln": "MVIQRSWKIPTDVGGSINSSTTSANEVQQRSSPGMQLQAANSSSDDSDCSNQTTHSMDTRVASPVEGVRKQTEKDVVPETNTITLSLLGESTSSDAESSQKYVTTPDMAENMLQRIRQRLGGSHNMESGGSAESAMRALELLRISVQQAFDAEVNELIKKYMQNYFKPAFGNIKENLGQHSVNEETLQKMSSCALLENAKAQYTNFVRQHRLVANATDQQRLALKRSAKQDLNPISKVFAGNAGFMPNKPMPCTATTANQLPTQNQNPAALLLSQPDLQPVQPLQQQQQQEQTQTQNQQQPQHRSTVTPLVGGTLPTPVRRQIFWNTAQISTTTKFVLDVQANLSFGFGTDGKERLASKHPELIRYLPDGEDREWLATRGIIPAENRSSRFLFLIYDEVCRLQQTHELYRHKTNIDLSMMLTFSVTDAMIHKMRLFFVDLNIKSRGLITNSYILPSQQQSGNTNNSHLRNALLQGASAQQHQQQVATPPSDETALKELPAASPTPCLQGQVVGSTTTPLKTKLAASSTLSSSHATLTALLNNGGAVVGATPTGNSTSSNIAKFRN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. :: * .:* :: : * * : * ** * :* : * .. :::*** :* ::: *:: :::***: :*: * *:::*:* ..*: * * : :. : :*:** :: :: : : : : *.*::: : . . :*:: . ..:: :.:: .*.:: . . :*:: *. *:.*::. :*.***. :** ::*:* : *: ***.*::* .* :*:.*** : : * . .:: :*: :* * : : ** ::.*. : :* :.. *:.*** :: *. :. :*: *.* : ", "identical_positions": 73, "similar_positions": 130, "identity": "12.92%" }, { "cls_id": "homologset.agr.HGNC:16162", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q78S06-1", "uniprot_id": "SYS1_MOUSE", "id": "Q78S06-1", "name": "Protein SYS1 homolog", "aln": "--------------MAG-QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDALVRSSP-SLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLSSAP---KSNV-----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZY25-1", "uniprot_id": "D3ZY25_RAT", "id": "D3ZY25-1", "name": "Protein SYS1 homolog", "aln": "--------------MAG-QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDALVRSSP-SLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWLYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLSSAP---KSNV-----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N2H4-1", "uniprot_id": "SYS1_HUMAN", "id": "Q8N2H4-1", "name": "Protein SYS1 homolog", "aln": "--------------MAG-QFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSP-SLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLNSAP---KSNV-----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FBT7-1", "uniprot_id": "E7FBT7_DANRE", "id": "E7FBT7-1", "name": "Protein SYS1 homolog", "aln": "--------------MAS-HFRSYVWDPVLIISQIVLMQCIYYSFLGLWLAGVDGLVQTSR-SLDQIFSYEVLGFSTTHGRLSMMAFILNSLTCAFGLWFFIRRGKQCLDFTVTVHFFHMIGCWIYNAHLPAALSWWLVNVACMALMAVIGEYLCMRTELRAIPVNTAP---KSNL-----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VHP1-1", "uniprot_id": "Q9VHP1_DROME", "id": "Q9VHP1-1", "name": "Protein SYS1 homolog", "aln": "--------------MKGGTFRNTQWDPTLLSSQIVSMQFCVYFTLGLLVFVANKLSGDNY-SLDHLFEYHEIHIYDMGGRLVICAFVLNAFLASLALWCIVRRAKLCLDFSCTFHVLHLLICWWYNRSFPANASWWLLNVITGTIMCIGGEFLCLQTEMKEIPVGYAALNQKSDV-----------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P41544-1", "uniprot_id": "SYS1_YEAST", "id": "P41544-1", "name": "Protein SYS1", "aln": "MVSIRRYLRVPNELKPSQIFKQDSLSPSKIGLQIVLLQIFYYTTAIVLFYCWAKLAGYDLNIKEWLFSWENIDFTNAYGLSISLLWLLDSLICVFFLTVIVGRSKLAWDFAITIHAINFIVVFLYTRKFP-SFSWFFLQILSSLILIFLGTWTTRWRELRDTFFEGLVDPNEGEVGLVTPSQQHSNHSELEQSPIQLKDLESQI", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . *:. .* : *** :* * : . * . : :*. . : : * ::*::: . : * :: *.* . **: *.* :::: : *. :* :*:::: :: . * : *:: . :.:: ", "identical_positions": 23, "similar_positions": 51, "identity": "11.27%" }, { "cls_id": "homologset.agr.HGNC:16163", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LQ66-1", "uniprot_id": "A0ABK0LQ66_RAT", "id": "A0ABK0LQ66-1", "name": "", "aln": "---MGCHGESWGDRLRPALTCRLRQIPSCFELCFLIHDALSLSGPASSWRSGA---LVLFLFLSLDQTSASYTAKIKQKVGECPRKRLDCRNGILSSCKTDFNCEAHFKCCHFACGRLCMDPYEEPCLLPSDAGNCKDTLTHWYFDSQKHKCRAFTYSGCGGNSNNFLSKADCRNACMFFVKKGQCPLFPFQMRMECPASCKNDMDCPEKEKCCESRCGFICARAWLDSCFQLGQQPGGIISLIDKRDPFIFPITLGMRYTQKSPT-CLVTQLSSCHFT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q4KUS1-1", "uniprot_id": "WFDC8_MOUSE", "id": "Q4KUS1-1", "name": "WAP four-disulfide core domain protein 8", "aln": "MAKCGVPQRVPGDCFRPVSTRHPRQIPSCFSICFLTHEAQSLRALAHSWWSGALLLLLLFLFLSLEQTSTSYNAKIKQKVGECPRQRLECRNESLSSCKTDFNCKAHFKCCQFACGRKCMDPYEEPCMLPSDKGNCQDILTRWYFDSQKHQCRAFLYSGCRGNANNFLTKTDCRNACMFVEKKGQCPLFPFQMRMECPASCKNDMDCPEKEKCCESRCGFICARVWLVKTGFCPRKP-IVCSKIDKPK---CLQDIDCPLDEKCCTRCGLKCLKPRH--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IUA0-1", "uniprot_id": "WFDC8_HUMAN", "id": "Q8IUA0-1", "name": "WAP four-disulfide core domain protein 8", "aln": "-------------------MWTVRTEGGHFP----------LHSPTFSWRNVA---FLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKP-LLCTKIDKPK---CLQDEECPLVEKCCSHCGLKCMDPRR--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . * * . : ** . * ::*:* *:*: **: . ***:* * **::** * . .**:***:*: : *** *** : ****::***:** ***:. :*:** ::::* .* * ** **:****.: **.***:. *.******** * ***.**:.*:***:.:*********:***.* . ::* : : *** . :*. : * :. :.. : ", "identical_positions": 103, "similar_positions": 64, "identity": "36.92%" }, { "cls_id": "homologset.agr.HGNC:16165", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CYC5-1", "uniprot_id": "DSN1_MOUSE", "id": "Q9CYC5-1", "name": "Kinetochore-associated protein DSN1 homolog", "aln": "--MTSVTRSE---DQEPTMSETQDRPLQPSLKPLEALPQSSAYQEMMTQGVSEEKNHLGSNPGEGESCGADHQEGSQLRSFHLSPQEQSIRPQDRRQSWRRASMKEVNRRKSLAPFHPGITELCRSISVKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLECFRAKASSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAADFSLEASVAEVKEYITKFSLERQAWDRLLLQYQNEVPPEEMPRGSTETRITEVKVDPAAYLRSSQKEVLSTKPDYQRIVQDQNQVFAYVELVMDELQGSVKQLQALMDESTQYLQKVSVQLKKRSMDQLDSSPARKLLKLPLQSSPSTQ--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AFX7-1", "uniprot_id": "A0A8I6AFX7_RAT", "id": "A0A8I6AFX7-1", "name": "", "aln": "MMMTSVTKSE---DQGPTMSETQDRPLQPSLEPLEALPRSSAYQEMMAQGTSEEQNHLGRSPREGEGCGADPQEGPQLRSFHLSPQEQSARHRDRRQSWRRASMKEINRRKSLAPFHPGITELSRSISMKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLECFRAKASSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAPDFSLEASVAEVKEYITKFSLERQAWDRLLLQYQNEVPPEEMPRGSTETKINEVNVDPAAYLRSSQKEVLNTKPDYQRIVQSQNEVFAYMELVMDELQGAVKQLQAFMDESTQYLQKVSVQLKKRSMEQLDSSPARKLLKLHLQSSSTTQ--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H410-1", "uniprot_id": "DSN1_HUMAN", "id": "Q9H410-1", "name": "Kinetochore-associated protein DSN1 homolog", "aln": "--MTSVTRSEIIDEKGPVMSKTHDHQLESSLSPVEVFAKTSASLEMN-QGVSEERIHLGSSPKKGGNCDLSHQERLQSKSLHLSPQEQSASYQDRRQSWRRASMKETNRRKSLHPIHQGITELSRSISVDLAESKRLGCLLLSSFQFSIQKLEPFLRDTKGFSLESFRAKASSLSEELKHFADGLETDGTLQKCFE-DSNGKASDFSLEASVAEMKEYITKFSLERQTWDQLLLHYQQEAK-EILSRGSTEAKITEVKVEPMTYLGSSQNEVLNTKPDYQKILQNQSKVFDCMELVMDELQGSVKQLQAFMDESTQCFQKVSVQLGKRSMQQLDPSPARKLLKLQLQNPPAIHGSGSGSCQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *****:** :: *.**:*:*: *:.**.*:*.:.::** ** **.***: *** .* :* .*. . ** * :*:******** :************* ****** *:* *****.****:.**:*:***.*********::******::**.****.***************:* * .******** **: **.**********:************:**:***:**:*. * :.*****::*.**:*:* :** ***:***.******:*:*.*.:** :*********:******:****** :******* ****:***.********* **...: : ", "identical_positions": 236, "similar_positions": 75, "identity": "65.37%" }, { "cls_id": "homologset.agr.HGNC:16166", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A3KGJ9-1", "uniprot_id": "A3KGJ9_MOUSE", "id": "A3KGJ9-1", "name": "", "aln": "MEHCWVF-WGLVLWMIAPCLYLTHELAPQQGWTYMVPQQCNWFCFKFGKRGCPSKSPNCSTCHHTAGEACYEKFMGYWRTKALWWLGMNSVSEHGTVWKKPSGVTPNSLLHHFDFHCVSCAMLG------NSGFSNINQLFYMAFRTNQASNHSSEAEMRSQTAGPFICPRNASHQGFWGQYWLLQLADLVPQVTRFWKMV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M0R6Y4-1", "uniprot_id": "M0R6Y4_RAT", "id": "M0R6Y4-1", "name": "", "aln": "MEHCWVVVLGLVLWLMPPCLDLTHELGPQQEWTYVVPHQCYWLCFKFGECGCHSKTPNCSTCHHTAGEACYQKTMGDLRTKALWWLGVNSVSEHETVWTKPSEVTPNPLLHHFDFHCVSCAMLG------NSGLSNINQLFYMAFRMNQASRHSSEAGMRNQITGPFICPRNASHQGSWGQHWLLQLADLVPQVTRFWKT-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96LM9-1", "uniprot_id": "CT173_HUMAN", "id": "Q96LM9-1", "name": "Uncharacterized protein C20orf173", "aln": "------------------------MLSGPHPSPTFRPNPCPWPCLHS------------LWMEISPTQLCFLSPGPSPQSPSCCFQGMNSGSELGKLWRKLFKGIPRLSVSHFDFYCGTCVLLGRPQIPQGSSLGNDIDQYPVVFRNASDQGSWMQLEMLLRKLSDLVWTSDALSD-------KILEDGLVP---------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. : . . *: * * *:: . :. : *: . :: : : *:** ** .:* * *. : ****:* :*.:** .*.:.* : : :.** . . : * : . :: . :* : : .*** ", "identical_positions": 31, "similar_positions": 46, "identity": "15.42%" }, { "cls_id": "homologset.agr.HGNC:16167", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2ADM8-1", "uniprot_id": "A2ADM8_MOUSE", "id": "A2ADM8-1", "name": "", "aln": "MEASEPTHPTPSATDQPASVPGIPGGLGGQASPRLTLGPVILPPEQGLAP-TVFLKALPVPLYHTVPPGGLQPRAPLVTGSLEGASVPFILSPLLQPEGPSATQVGKPATPALTVNIVGTLPVLSSGVGSALVSTGRVKNTGKYLCPHCGRDCLKPSVLEKHIRSHTGERPFPCPTCGIAFKTQSNLYKHRRTQTHLNNSRLSLESEGSGSSLLEEGDRPGETASVDSRGD-------EGAPERALSPGALPALAAQNRERKVESAPSLGATLSHREASADHTQMVSPEFSLASPQPRRKLPEPK------PCFLQRQQETCSEKPWDPKALEGQLRKCESTDSGYLSRSDSVEQPPVASSPLHSLSEHSAESEGEGGPGCSSSGNRAERGTPGPSLELEKKKLEERIAQLISHNQAVVDDPQLDHVRPRKTVLSKQGSIDLPMPYTYKDSFHFDIRALEPSRRRAALSPARSTFTPLEKARPLFFHSVPTQLSTTVECVPVTRSNSLPFVEGSKLWPEQ-RDPQDAVPGMQKALSPRPTPARLGCRPGLTLASISSGHPRALVRQAAVEDLPCTPTGDPSAAAEELDGKRAVAKEGVVYKGRAS-KKCSQRKQRMFSQEKWQVYGNETFKRIYQKMKTNHQGGQKHRQVKQGQGTELDFPPPPPPQKQGGGGEDTGLSQDSRIPILGDTTAGCKLESWGSRPSLEDSLEAESPKQLKVVTR-----------VKSSPTLGSTDSLCLSGKSSLLSPSGKLDLGCQPPPVPTACQAGDLEAPETASPDSSGE-------AIKETSPGAQTVLRRSSDGSVALQLAEDKLPSERKRLKVEGLDHQEQPGPLEADTSGGSVQADPPPSERQDSDSEELLGCSNKSTLHVTTAPEPSDVSSAASPVALQWPGIGDKDSPLPSVPRTPGLHSLLPAQPQDPGVPNARSGGFFPPKYLLRLPQGENPSPIVAA-GPEKGSDSLCTSTQPVEQALLVGSELGMLRPPGAYSGP--GEAGGSPDDPSWSRLRDGKEEAQTGREKRDRTKDNILVVGHSPVPITSTTQEIASVLSTHTCDIRVAQDVVSKTHAIHCLCTDSPPARARTYGNLLNPWTSSQKLGIPPKSALEGPPSETKEGLPAFFSSQAHYFLTTFTKPQDISLNQQKPALSHVLGTPRSCEAPS------SFPSLKTEPQLTWCCLSRSLPLPAEQR-RIAPGHLASSLPNRNLQGDSNKTLPKSNGGRTQTSQGGEVSTQAPELPYPSVPELRAEDQVSRPRWKKEQLWRRKVKTSRENTKQKKLRLHSKRCEGSFWQ-----RAKRLCKPPWLPRRSCLPHRLEGLEPRGTLGRSSAEVAGRNVQGEPSCASKDLSVSHGNKEKE-GDCSQTSRPMSPGMSSKTMLEMDKSALKDISPTTGEHNDCSQEKEHAGGSGLSPQSNTFLAVFQED-VPQGKGLDVGPPETQLPPSQDQVSITPNLCFSPDVPELPSSFKPKGTFPHHDVATSVAAICVSAGIRTGRKTLRAHSAES-----CAEETLARNSPDRRGTPDSIPRVLLPGRPSPGK---------QSPGQTLEIPSSGPSSVSSLQEEARAQADFPWWGQYGCGDLTVQGAASGSESRTCQAEGLITSKTVTAPSDPGQPSQVPEEAPLRSIRKRSLEGMRKQTRVELSDTSSDDEDRLVIEI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JZX4-1", "uniprot_id": "A0A0G2JZX4_RAT", "id": "A0A0G2JZX4-1", "name": "", "aln": "METSEPTHPPPSSTDQQASVPGIPGGPGGQASPRLTLGPVILPPEQGLAP-TVFLKAWPVPLYHTVPPGGLQPRAPLVTGSLEGASVPFILSPLLQPEGPSATQVGKPATPALTVNIVGTLPVLSPGVGSALVSTGRVKSTGKYLCPHCGRDCLKPSVLEKHIRSHTGERPFPCPTCGIAFKTQSNLYKHRRTQTHLNNSRLSLESEGSGSSLLEEGDRPGETASVDSRGD-------EGAPERALSPSVHPTLAAQNRERKVD---SLGATLSHREASVDQTQMVSPEFPLASPQPRRKLPEPK------PGFLQRQQETCSEKPWDPRALEGQLRKCESTDSGYLSRSDSVEQPPVASSPLHSLSEHSAESEGEGGPGCSSSGNRAEQGTPGPSLEIEKKKLEERIALLISHNQAVVDDPQLDHVRPRKTVLSKQGSIDLPMPYTYKDSFHFDIRALEPSRRRVALSPALSTFTPLEKARPLFFHSVPTQLSTTVECVPVTRSNSLPFVEGSKLWPEPPRDSQDAVPGVQKALSPRLTSARLGCRPGLTLASIPSGHPRALVRQAAVEDLPCTPTGDPSAVAEDPDGKRAVAKEGVAYKGRAS-KKCSQRKQRMFSQEKWQVYGNETFKRIYQKMKTNHQGRQKHREVKPAQGTELGLP---PPQEQIGGSDDAGLSQDNRIPILGDTTAGAKPGSWRSRPSLEDSLEAESLKQLKAVAR-----------VKSSPTLGSTDGLCLSGKSPLLSPSGKLDLGHQLPPMPGPCQGRDLEAPETASPDPSGE-------VIKETSPGVQTVLRRSSGGSVAPQLAEDKLPSERKRLKVEGLDHQEQPGPLETETSGGSVQADPQPSQKQDSDPREVLGCSNKSILHVSTAPEPSDVSSAASAVALRCLGLEDQDSLLPSVSRTPGLHSLLPAQLQDPGVPTAQSGVSFAPKYLLRLPQGENPLSLVAP-GSGKGSDSLCTSTQPVEQALLVGSELGMLQPPGAYSGS--GEAGGSPKDPSWSKSRDEKEEAQTGREKRDRTSDSIRGTRRSPDPRTSTIQEIASILSTHTCDIHVAQGVVSKAHAIPCLCTDSPPARARTCGNLLNPWTPSQKLGTPPKNAAEGPPLETKEGLPTCFLSQAYYFLTTFTKPQAISLNQQKLALSHSLGNPRSGEATS------SFPSLKAEPQLTWCCLSRSLPLPAEQQ-RAAPGHLASSLPNRNLQGDSNKTLPESSRGRTQTGRGGEGSTQTPELPYPTVPGLRAEDQVSRPRWRK-ELWRRRVKTSRENAKQKKLMLQSKRCEGSFWQ-----RAKRLCKPPWLPRRSCLPHRLEGLEPRGTFGRSSAEASGLNVQGEPSCASKDLSVDRRNKDGK-GDCSQTSGPTSPATNSKTILETDKSTLKDISPAAGERHDCSQEKEHADGFGLSLQSNMLLAGFQED-LPQGKGLGVEPPGAQLLSSQDQVSIVPNLSFSSDVPQLPSSFRSKGIFPHHDIATSVAAIYVSEGIGTGHKTLGPHGTES-----CAEEPLARNSPDRRATPDSIPQVLLPGRPSPGK---------QSPGKTLEIQPSVPNSVGSHQEEARAQADFPLWGQYGCGDLTIQGAASGSESGTCQAEGLITPKTVTAPSNQGQPSEVPEAR-LRSIRKRSLEGMRKQTRVELSDTSSDDEDRLVIEI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5JPB2-1", "uniprot_id": "ZN831_HUMAN", "id": "Q5JPB2-1", "name": "Zinc finger protein 831", "aln": "MEVPEPTCPAPPARDQPAPTPGPPGAPGGQASPHLTLGPVLLPPEQGLAPPTVFLKALPIPLYHTVPPGGLQPRAPLVTGSLDGGNVPFILSPVLQPEGPGPTQVGKPAAPTLTVNIVGTLPVLSPGLGPTLGSPGKVRNAGKYLCPHCGRDCLKPSVLEKHIRSHTGERPFPCATCGIAFKTQSNLYKHRRTQTHLNNSRLSSESEGAGGGLLEEGDKAGEPPRPEGRGESRCQGMHEGASERPLSPGAHVPLLAKNLDVRTEAAPCPGSAFADREAPWDSAPMASPGLPAASTQPWRKLPEQKSPTAGKPCALQRQQATAAEKPWDAKAPEGRLRKCESTDSGYLSRSDSAEQPHAPCSPLHSLSEHSAESEGEGGPGPGPGVAGAEPGAREAGLELEKKRLEERIAQLISHNQAVVDDAQLDNVRPRKTGLSKQGSIDLPTPYTYKDSFHFDIRALEPGRRRAPG-PVRSTWTPPDKSRPLFFHSVPTQLSTTVECVPVTRSNSLPFVEGSRTWLEP-REPRDPWSRTQKPLSPRPGPARLGCRSGLSSTDVPSGHPRALVRQAAVEDLPGTPIGDALVPAEDTDAKRTAAREAMAGKGRAGGRKCGQRRLKMFSQEKWQVYGDETFKRIYQKMKASPHGGKKAREVGMGSGAELGFP----LQKEAAGSSGTVPTQDRRTPVHEDISAGATPEPWGNPPALEASLVTEPTKHGETVARRGDSDRPRVEEAVSSPALGGRDSPCSGSRSPLVSPNGRLELGWQMPPAPGPLKGGDVEAPRPVWPDPKLEGGARGVGDVQETCLWAQTVLRWPSRGS-----GEDKLPSERKKLKVEDLHSWKQPEPVSAETPGGPTQPASLSSQKQDADPGEVPGGSKESARQVGEPLESSGASLAAASVALKRVGPRDKATPLHPAAPAPAEHPSLATPPQAPRVLSALADNAFSPKYLLRLPQAETPLPLPIPWGPRHSQDSLCSSGWPEERASFVGSGLGTPLSPSPASGPSPGEADSILEDPSCSRPQDGRKGAQLGGDKGDRMATSRPAARELPISAPGAPREATSSPPTPTCEAHLVQDMEGDSHRIHRLCMGSTLARARLSGDVLNPWVPNWELGEPPGNAPEDPSSGPLVGPDPCSPLQPGSFLTALTRPQGVPPGWPELALSSHSGTSRSHSTRSPHSTQNPFPSLKAEPRLTWCCLSRSVPLPAEQKAKAASVYLAVHFPGSSLRDEGPNGPPGSNGGWTWTSPGEGGPAQMSKFSYPTVPGVMPQHQVSEPEWKKGLPWR--AKMSRGNSKQRKLKINPKRYKGNFLQSCVQLRASRLRTPTWVRRRSRHPPALEGLKPCRTPGQTSSEIAGLNLQEEPSCATSESPPCCGKEEKKEGDCRQTLGTLSLGTSSRIVREMDKRTVKDISPSAGEHGDCTTHS-TAATSGLSLQSDTCLAVVNDVPLPPGKGLDLGLLETQLLASQDSVSTDPKPYIFSDA-QRPSSFGSKGTFPHHDIATSVAAVCISLPVRTDHIAQEIHSAESRDHSQTAGRTLTSSSPDSKVTEEGRAQTLLPGRPSSGQRISDSVPLESTEKTHLEIPASGPSSASSHHKEGRHKTFFPSRGQYGCGEMTVPCPSLGSDGRKRQVSGLITRKDSVVPSKPEQPIEIPEAP-SKSLKKRSLEGMRKQTRVEFSDTSSDDEDRLVIEI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**..*** *.*.: ** *..** **. ******:******:********* ****** *:**********************:*..*******:******..*******:*:*************.*:*.:* *.*:*:.:*********************************.**************************** ****:*..******:.**.. :.**: ***.**.***.. .* *:* : :.: . *::::.***. * : *.** :. **.** ***** * * ***** *.:*****.:* **:*****************.*** ...******************** ... ** *: ..**:***:****** ***********.***:****** ********** *****************.***.. *. **:** :*:*********************************: * * *:.:*. . **.**** .******.**: :.:.***************** ** **. . **: *.**:.*:*.:. ****. :**.**: :***********:***********:. :* :* *:* ..*:**.:* *:: .*...: :** * *: * :**.. .* . *:** ** :*. *: :.*:* . ***:**. *. * ..:*.*:**.*:*:** * ** * . :. *:***... **.. * ::**. .***** .* ** .*********:****.*. :** *:.::*.**..*. . .*::**:*. *: * *::* :* . *.*..* **:.***: * *: : * ... :*. *. *.: * * * .* :. *.*********.*.* .: . *. :..****:* * *:* :*** ** .*.. **. ***.. .*** *: :* :: ** * :* ** . . . * . ..: :* :* .* **: ::.*.: ..:* * ** .*. **** *::****... :** ** .* *.*. . * . *. ***::*:** :. . : *** *..** .: * .*****:**:*********:******: : *. :** :*. .*:.:. : * *. * * *. * .:* .::.**:** : .:.***.*.*:* ** .* ** *:**:** ::.** :*.* * **.** .*.*: *** * ****:* * *::*:* :* *:* *****:.: . ::: : *** ** . * . .*: : * ** ::*****::**: **: .. * *** **: ** .:: :* ****.: :** .***.** *: : .*. : **** .** *****:******: :* : *.: : *.:** * ..*: .*** : * :. .:.*******.*: .: *** .* *.*..* ::*.* :: ** ******::*: .: **:. . *..**** * ..**. ** ::** :*::**************:***************", "identical_positions": 866, "similar_positions": 424, "identity": "51.15%" }, { "cls_id": "homologset.agr.HGNC:16168", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZX40-1", "uniprot_id": "D3ZX40_RAT", "id": "D3ZX40-1", "name": "", "aln": "MSVRLRFLSPGEAGAVGTVGRSASFAGFSSAQSRRVSKSINRNSVRSRLPAKSSKAYGTLRKGSLCLDPRPQQVKKIFDALKRGLREHLCEQQAELDYLCRCHTDTQRSSRLAFYYDLDKQMRMVERHIRKVEFHISKVDELYEGYCIQWRLRDGASNMQRAFSNSTQSRASRESLQELGRSLQECLEDMCLIEGTLEGHLGEFHVKMKGLVGYARLCPGDQYEVLMRLGRQRWRLKGRIEPDDSQTWDEEERVFVPTVHENLEIKVTELRGLGSMVVGAVTCDVADFFTARPQLVVVDITELGTIKLQLELLWNPLDSECRLVSPSPTGRFSVGSRKGSLYTWTPPSTPSFRDKYYLSVLQQP--MQQALLLGG--PRATSILGYLSDS--ELQGPRLRSRS----QELLEMDSFSSED-----PRDTETSTSASTSDVGFLPMPVAP--TACIEEETREEPPPLGLLPGLTHPAG-GVLVEQPGWRDLRGERLDLLLDDPIHSPTVPRSRKGQEDGGAGDG-------VEGPVQEVLDLLRSADPAQPQLRELEYQVLGLRERLKPRGVQPEPVSAQSLMD---CILESFAFLNADLASDELSLFGGSQALERDSPPPPRPSLKVS----------PSE------------------LTAGTPELDTLLTVHLQVCKALLQKLASPNLSRMVQDCLLEEAVQQRQVLEVLSDLDLEQVSKAKSVEEIIPQASQRKGGLALWQGCTQPGGVLACPASTLLSQLKKTFLHRVRGKYPGQLEIVCRRLLEQVLGCGGLFVTAGLQDEQVVTWFQFHSYLQRQNISDLEKHLTQLTKEVTLIEELNCAGPAKALRKLHGKRLSQLQPLPQTLQAWARLQLDGPPRLCRAARMRLASAARNKRFREKALLYYTNALNDSDSKLQQAACMALQQLGGVESIEQIVSLCQSDLEAVRAAAREATLSFGEKGRLAFEKMDKLHAEQ-EAFCQEADVEITIF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A1L3T7-1", "uniprot_id": "RIPR3_MOUSE", "id": "A1L3T7-1", "name": "RIPOR family member 3", "aln": "MSVRLRFLSQGDAGAVGTVGRSASFAGFSSAQSRRLSKSINRNSVRSRLPAKSSKAYRTLRKGSLCLDPRPQQVKKIFDALKRGLREHLCEQQAELDYLCGRHTDTQRGSRLAFYYDLDKQLRLVERHIRKVEFHISKVDELYEAYCIQWRLRDGASNMQRAFSNSTQSRASRESLQELGRSLQECLEDMCLIEGTLEGHLGEFQVKMKGLVGYARLCPGDQYEVLMRLGRQRWRLKGRIEPDDSQTWDEEERVFVPTVHENLEIKVTELRGLSSMVVGAVTCDVADFFMARPQLVVVDITELGTIKLQLELLWNPLDSECRLVSPSPTGRFSMGSRKGSLYTWTPPSTPSFRDKYYLSLLQQP--VQQSLLLGG--PKATSILGYLSDS--ELQGPRLRSRS----QELLEMDSFSSED-----PRDTETSTSASTSDVGFLPVPVGS--AACTEEETREGPPPLGLLPGLAHPAR-GVLVERPGWRDLGGERLALLQDAPIHSPMVPRSRKGQEDGDVGDG-------VEGPVQEVLDLLRSADPAQPQLRELEYQVLGLRERLKPRGVQPEPVSAQSLMD---CILESFAFLNADLASDELSLFGGSQAPERDSPPPPRPSLKVS----------PSE------------------LTAGAPELDTLLTVHLQVCKALLQKLASPNLSRMVEDCLLEEAVQQRQVLEVLSDLDLEQVSKARSVEEIIPQASHRKGGLALWQGCTQPGGVLACPASTLLSQLKKTFLHRVRGKYPGQLEIVCRRLLEQVVGCGGLLVPAGLQEEQVVTWFQFHSYLQRQSISDLEKHLAQLTKEVTLIEELSCAGPAKALRKLHGKCLSQLQPLPQTLQAWALLQLDGPPRLCRAARTRLASAARNKRFREKALLYYTNALNDSDAKVQQAACVALQQLGGIESCEQIVSLCQSDLEAVRVAAREATLSFGEKGRLAFEKMDKLHSEQ-EAFCQEADVEITIF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96MK2-1", "uniprot_id": "RIPR3_HUMAN", "id": "Q96MK2-1", "name": "RIPOR family member 3", "aln": "MSVRLRFLSPGDTGAVGVVGRSASFAGFSSAQSRRIAKSINRNSVRSRMPAKSSKMYGTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQAELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKVDELYEDYCIQCRLRDGASSMQRAFARCPPSRAARESLQELGRSLHECAEDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEEKAFIPTLHENLDIKVTELRGLGSLAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGKFSMGSRKGSLYNWTPPSTPSFRERYYLSVLQQP--TQQALLLGG--PRATSILSYLSDS--DLRGPSLRSQS----QELPEMDSFSSED-----PRDTETSTSASTSDVGFLPLTFGP--HASIEEEAREDPLPPGLLPEMAHLSG-GPFAEQPGWRNLGGESPSLPQGSLFHSGTASSSQNGHEEGATGDREDGPGVALEGPLQEVLELLRPTDSTQPQLRELEYQVLGFRDRLKPCRARQEHTSAESLME---CILESFAFLNADFALDELSLFGGSQGLRKDRPLPPPSSLKAS----------SRE------------------LTAGAPELDVLLMVHLQVCKALLQKLASPNLSRLVQECLLEEVAQQKHVLETLSVLDFEKVGKATSIEEIIPQASRTKGCLKLWRGCTGPGRVLSCPATTLLNQLKKTFQHRVRGKYPGQLEIACRRLLEQVVSCGGLLPGAGLPEEQIITWFQFHSYLQRQSVSDLEKHFTQLTKEVTLIEELHCAGQAKVVRKLQGKRLGQLQPLPQTLRAWALLQLDGTPRVCRAASARLAGAVRNRSFREKALLFYTNALAENDARLQQAACLALKHLKGIESIDQTASLCQSDLEAVRAAARETTLSFGEKGRLAFEKMDKLCSEQREVFCQEADVEITIF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5EB20-1", "uniprot_id": "RIPR3_DANRE", "id": "Q5EB20-1", "name": "RIPOR family member 3", "aln": "MSVKLKFDYPADG---GMVQRSRSFTGVNTLGGRRRLSSARSSLRSKAVTGKSPRIPSNSRAGSSVWGQQPEQVDRIFQALRKGLKDYLESHQTELDFLSSQQRDTKRNSRLAFFYDLEKEIRALERYIRRLEFQISKVEELYESYCIQWRLCQGALNMKRAFSLSPSSRQSRESLLELNRNHRHSLEDMSAMEAELEILLGELHVKMKGLIGFARLCPGDQYEVLIRLGRQRWRIRGRIQTDDRQMWDEEEMVFLPHIHGNFEIKVTEVKGLSSILVGMVTCRSADFFTARPQMMVVDITELGTIKLQLEVVWNPFDSTEVRPLTASASRQSIHSRKGSVYSWTPPNTPSFTEKYFLSMMRQMQDADGSFSIGSRESRGVSLLSYLADSTQALSPPAYEKTSGPPVAQHTVLDAKIQDDDLLKTHTDAEESVEWPSETDTASPSPAGSKRDSIFLFHRYSTPDILKQSGEMSVSAGEGDAQETTNPDEATEQETSFKQETEDRVAVKDRKPSRAQKKAVAKR--------VSALLEDLNTALEETSNVETLKKLDLQIRQLNHVLKKDLDASQVPSSQTLAVEEEEVLGSFDFLSADCTEDEMPIMSSIRLGNTGIGSFNESTLKSMGLLCQEQRCVSSEDSAEGQVRLRGDAAVKASVTTGVYSLDQALETHLSVCAVLLRALKQSD-SDLVHKDIMDELSRQVNVLEKIAALSQKLIDEISAADLLSKTP---KGIEVFWKECCESDSAFCCSTEAFLRALRKHFIHKVKAKEPGQTDAVFNQLLHQVQ-CSGMVASVTLCTAERLTVFQLLVYLSRWSITDFGEHISLLSKEVYLIACLESPKRRRALKKLKGKRISDLQPTGRILQLLAKLQTDANHKVASAASSCLNRASRSKSFRAKAVVHYTDLLKNSNTNVRHEACLALKSLKASESAEQVAELWRSADEDLRNAARETVLSFGKKGQMAFQRMDQIYELQ-DEAYKNLETEITIL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:*:* .: * * ** **:*..: .** .* . . . :..**.: . * ** . :*:**.:**:**::**:::* :*:***.*. : **:*.*****:***:*: * :**:**::**:****:**** **** ** :** .*:***: .. ** :**** **.*. :.. *** :*. ** ***::::****:*:*******:****:*******:::***:.** * ***** .*:* :* *::*****::**.*: ** *** **** :***::***************: ***:*: .:.:.: *: *****:*.****.**** ::*:**:::* : :: :*. .:..*:*.**:** * * .. * : :*: .:* *:* *.. .:. * . .. : . . * :: : * * .. : : : : . . :. ... ..: * *: . *::*: *: :.. ** : *:::* :* ** **.** : **:.::.. : . . .:** . * :*:*. .** * .**.** .**: * ..: * :*.. :::* :* :*** :: *. : :.: : : : . ** :*: * .. .:.*.: ::* *:* * *:*:.* *** : . .:**.** *.*:. . * : :* **: **.* .::*: :*:: *:*** ** * .. :.::**:** :.:*** : *: * ** *. ::. ** * * *.: ** **::.**: * :.::.::: **:**: * . ** :* ..* :* * :* ****:.****:**::**::**:: * : :: :.****:", "identical_positions": 340, "similar_positions": 301, "identity": "34.17%" }, { "cls_id": "homologset.agr.HGNC:1617", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7TPB1-1", "uniprot_id": "TCPD_RAT", "id": "Q7TPB1-1", "name": "T-complex protein 1 subunit delta", "aln": "MPENVASRSGPPAAGPGNRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTS--PGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P80315-1", "uniprot_id": "TCPD_MOUSE", "id": "P80315-1", "name": "T-complex protein 1 subunit delta", "aln": "MPENVASRSGAPTAGPGSRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDVEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVSLNGSGKLFKITGCTS--PGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P50991-1", "uniprot_id": "TCPD_HUMAN", "id": "P50991-1", "name": "T-complex protein 1 subunit delta", "aln": "MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNS--GITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCAS--PGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VK69-1", "uniprot_id": "Q9VK69_DROME", "id": "Q9VK69-1", "name": "T-complex protein 1 subunit delta", "aln": "----MAPKAAAVNIKPTAK---AFKDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGGTVEDTELVDGLVFTCRSAGSN-APKRIEKAKIGLIQFCISAPKTDMDHNVIVSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVAS-GTNKFVKITGIQN--MGRTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDIVNTFS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39078-1", "uniprot_id": "TCPD_YEAST", "id": "P39078-1", "name": "T-complex protein 1 subunit delta", "aln": "----MSAKVPSNAT---------FKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD-ENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGS-KIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::.: . ::::.** ::* :** **::*:*********:******: ..*:: *:*** ****** :***.*:****:* *** *********:::*:** :. :**:**:*** *::*** . ::.::** :*. :.*.*** *:.:*:***.**:*** **:*:*::*::*:*: * . ..***.:*:::..:***::* *:::*:*:* * . .* ********** :*.**.* :::::*.** **::*:***:*:**: *:***: *****:********:.*** ***.*:: **:**:***:***:.* : :*:* :: ** : *.**:*.**: *: *:.::** . **::: **:*:::::*: **:******:***** *. *.********:: :*: ::::.*:::: : **.*:****:*********.* .*****.:* :** . **.**:.. :: * ::**:*** *::***:* ::***:***:. : ", "identical_positions": 260, "similar_positions": 182, "identity": "47.79%" }, { "cls_id": "homologset.agr.HGNC:16170", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZSF0-1", "uniprot_id": "D3ZSF0_RAT", "id": "D3ZSF0-1", "name": "", "aln": "MLEGRLPSVSLLSVFFCFQFRWLFSFSEDKGNKEVTSPAVIIRQQIEQEDSEHCREEGRAAAKGCSINAGSSWNQVQPLKISSGK------RPSELQGPRVSSQPRSSLLGISQPAADKLVETIPREGRQEQAELSSRYQAASG---GRLFLDFHSMEIIKGGADEDSASDLSDSERVAIPPSPFTPPDLNLRAEEIDPVSFSLHPEPSQAESGHCYPDFLPPPFNSWDLRDMAVVLNTECRTEALPRATGLLGKYIDRLLQLEWLQVQTVQGEKARAAKAKL---PGAAGGLKSPGRGKLLTSSLSKPLPSPEGISKPGPSRKKGFRHEEAHPSYYAFETLPNSGDGPGRP----RLCSQKQAPEPRME-KKKKSSKGPKPQ----LRAPPCVEGNPAMEANGNIRIPKQSPVLLDPVGSYRASRTQAHVDLKKKGSANNCGCAPSSGEKKLKTNGAKQSTYKLK--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AJW5-1", "uniprot_id": "A2AJW5_MOUSE", "id": "A2AJW5-1", "name": "", "aln": "--------------------------------------------------MRDCHQK-------SSINAGSSWNQVQHSKTTSGK------RQSGSQGPHVSSQLRSSLLGISQPAAEKLMETVPTEGIQEQAALSSRYQAASG---SKLFLDFHSMEIMKG-ADEDSASDLSDSERVAIPPSPFTPPELNLRAEEIDPVSFSLHPELSQAESRQTYPDFLPPPFNSWDLRDMAVVMNSECRSEALPRATGFLGKYIDRLLQLEWLQVQTVQCEKARAAKAKP---PGASGVLKSPGRGKLLTSALSKPLPSPEGISKSGPSRKKGFRHEEAHPSYYAFETLPNSVDGPGRP----RLCSQKQAPELRME-KKKKSSKGPKLQ----PRAPPCAEGNPAMEANGNIRIPRQSAVLLDPVDSHRASRTQAHVDLKKKGSANTCGYAPSSSEKKLKTNGAKQSTYKLK--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NTX9-1", "uniprot_id": "F217B_HUMAN", "id": "Q9NTX9-1", "name": "Protein FAM217B", "aln": "------------------------------------------------------------------MNAGPSWNKVQHSKNSSGK------RQSKSQVPHASSQPRSSLTAVTQPTEEKLKESISPEARRKRNPLGSRCQGASG---NKLFLDFQSMKIIKENADEDSASDLSDSERIPIPPSPLTPPDLNLRAEEIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMALLLNAENKTEAVPRVGGLLGKYIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGALKSPGRSKLIASALSKPLPHQEGASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGGT----RFCSQRQTLEMRTEEKKKKSSKSTKLQ----RWDLSGSGSSSKVETSGHIRVPKQAAVILDSADSCKASKTQAHAHPRKKGKAESCGHATVSSEKKLKTNGVKQNTYKLK--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5G3-1", "uniprot_id": "A0ACD6B5G3_DANRE", "id": "A0ACD6B5G3-1", "name": "", "aln": "-------------------------MGTVLQESTVYNSLNLNHSQYKAARHAAASKKTSKAPVLPTPNTSPSSEPVCQQRLRRIRPDTMLIMANPTHRQQSSVKLRSHAASKNGHKDNRKNPGAVKESEGKANSVKSDTVNAEREEPSDCRTEEESCSSRSKAGGDDSASDISDSERYSVLPAKISPPDLDLRAEVIDGPDPLHSFKPTNRVQRSSFPDFLPPPFNSWSLTQLAVYLNTDGKTIPRPKPVGQLERYLDRLLQMEWHQIQTLQEDSSKSAPKHR--HPTPHSSLSAPKCILQCQRAFPLGLLSSMTSLHLSCTHCHNHYSNGSYRQHTRLHTEKRSSGVPQRSSSESRTRSEPRHREHRLSDPLSESRHLRRMQAAGNIRNPVSTCSPEPLSDAGEVKKRRPGRRSQSSVG-AREFGSRVRGRSEQRKTQEDCVLSSAGASDALRGSKESSRLNRKQKRVEFLTQ", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:..* : * : : . : : * : ** . . :: *. : : * *. . : .* . . ..:*****:***** .: *: ::**:*:**** ** : :*:***.**.**.* ::*: :*:: :: . *: * * :*:***:*:** *:**:* :.::.. : * . . *.:* ::. * : . :: : . : : .: :.* .. . . * *: : * * . .:* : : * . :. *.:: : . .... : ::.: .:: . : * :. .... *: . .. : : ", "identical_positions": 69, "similar_positions": 127, "identity": "14.56%" }, { "cls_id": "homologset.agr.HGNC:16171", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D8B3-1", "uniprot_id": "CHM4B_MOUSE", "id": "Q9D8B3-1", "name": "Charged multivesicular body protein 4b", "aln": "MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGE-EFDEDELMAELEELEQEELDKNLLEISG---------PETVPLPNVPSVALPSK---PAKKK--------EEED-DDMKELENWAGSM--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZP83-1", "uniprot_id": "A0A8I5ZP83_RAT", "id": "A0A8I5ZP83-1", "name": "", "aln": "MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGE-EFDEDELMAELEELEQEELDKNLLEISG---------PETVPLPNVPSVALPSK---PAKKK--------EEED-DDMKELENWAGSM--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D4A9Z8-1", "uniprot_id": "D4A9Z8_RAT", "id": "D4A9Z8-1", "name": "", "aln": "MSVFGKLFGAGWGKAGKGDPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEQTSTAISKPVGFGE-EFDKDELMAELEELEQEELDKNLLEISG---------PETVPLPNVPSVALPSK---PAKKK--------EEED-DDMKELENWAGSM--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H444-1", "uniprot_id": "CHM4B_HUMAN", "id": "Q9H444-1", "name": "Charged multivesicular body protein 4b", "aln": "MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGE-EFDEDELMAELEELEQEELDKNLLEISG---------PETVPLPNVPSIALPSK---PAKKK--------EEED-DDMKELENWAGSM--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZVC4-1", "uniprot_id": "CHM4B_DANRE", "id": "Q7ZVC4-1", "name": "Charged multivesicular body protein 4b", "aln": "MSLFGKMFGSG-GKGGK-SASPQEAIQRLRETEEMLTKKQEFLEKKIEQELVTAKKNGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENAHTNTEVIKNMGYAAKAMKAAHDNMDIDKVDELMQDIIEQQELAQEISDAISKPVGFGE-EFDEDELLAELEELEQEELDKNLLEIG-----------DNVPLPNVPSTSLPSR---PAKKK--------EEEDEDDMKDLEAWAAN---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6IQ73-1", "uniprot_id": "CHM4C_DANRE", "id": "Q6IQ73-1", "name": "Charged multivesicular body protein 4c", "aln": "MSVFGKLFGGG-GKGGK-GPTPQEAIQKLRETEEMLAKKQDFLEKKIDAELLIAKKNGTK-NKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGFAAKAMKTAHENMDIDKVDDLMQDITEQQELAQEISDAISRPVGFGE-EFDEDELMAELEELEQEELDKDLLQISG---------PEDVPLPNVPSNPLPKKTAVAQKKR--------QEEDEDDMEELKAWAM----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8T0Q4-1", "uniprot_id": "CHM4_DROME", "id": "Q8T0Q4-1", "name": "Charged multivesicular body protein 4", "aln": "MSFFGKMFGGK----KEVAPTTGEAIQKLRETENMLIKKQEFLEAKIEDELNIARKNASK-NKRVALQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTAVLTTMKNAADALKRAHQNMDVDKVHDMMDDIAEQQDVAREISDAISNPVAFGA-DLDDEDLERELDELEQENFDKEIIGIP----------EPTPTLPEAPTEDLPEK---AKEKKKATTTTAVEDDDDPDMKQLLSWSN----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39929-1", "uniprot_id": "SNF7_YEAST", "id": "P39929-1", "name": "Vacuolar-sorting protein SNF7", "aln": "--MWSSLFGWT-SSNAKNKESPTKAIVRLREHINLLSKKQSHLRTQITNQENEARIFLTKGNKVMAKNALKKKKTIEQLLSKVEGTMESMEQQLFSIESANLNLETMRAMQEGAKAMKTIHSGLDIDKVDETMDEIREQVELGDEISDAISRPLITGANEVDEDELDEELDMLAQENANQETSKIVNNNVNAAPISENKVSLPSVPSNKIKQSENSVKDGEEE------EDEEDEDEKALRELQAEMGL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:..:** : :. :** :**: ::* ***..*. :* : *: :* ** * :***:** *: * :::**:.::* * ::*.*: * .: * .*.*:* *..:*:***.: *::* :* ::. : * ***.*: * :.*.::* **: * **: ::: * .**..*: : . . . :::: * : * ", "identical_positions": 62, "similar_positions": 77, "identity": "24.9%" }, { "cls_id": "homologset.agr.HGNC:16172", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A728-1", "uniprot_id": "D4A728_RAT", "id": "D4A728-1", "name": "Barrier-to-autointegration factor-like protein", "aln": "MDNMSPRLKAFLSEPIGEKDVAWVDGISCELAINLVTKGFNKAYVLLGQFLLMHKNEAEFQRWIICCCGATECEARQSSTCLKEWCACFL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BVR0-1", "uniprot_id": "BAFL_MOUSE", "id": "Q8BVR0-1", "name": "Barrier-to-autointegration factor-like protein", "aln": "MDDMSPRLRAFLSEPIGEKDVAWVDGISRELAINLVTKGFNKAYVLLGQFLLMHKNEAEFQRWIICCCGATECEARQSSTCLKEWCSCFL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H503-1", "uniprot_id": "BAFL_HUMAN", "id": "Q9H503-1", "name": "Barrier-to-autointegration factor-like protein", "aln": "MDNMSPRLRAFLSEPIGEKDVCWVDGISHELAINLVTKGINKAYILLGQFLLMHKNEAEFQRWLICCFGATECEAQQTSHCLKEWCACFL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VLU0-1", "uniprot_id": "BAF_DROME", "id": "Q9VLU0-1", "name": "Barrier-to-autointegration factor", "aln": "MSGTSQKHRNFVAEPMGNKSVTELAGIGETLGGRLKDAGFDMAYTVLGQYLVLKKDEELFKDWMKEVCHASSKQASDCYNCLNDWCEEFL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.. * : : *::**:*:*.* : **. *. .* *:: ** :***:*:::*:* *: *: *:. :* : **::** **", "identical_positions": 31, "similar_positions": 29, "identity": "34.44%" }, { "cls_id": "homologset.agr.HGNC:16173", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZM9-1", "uniprot_id": "DOK5_MOUSE", "id": "Q91ZM9-1", "name": "Docking protein 5", "aln": "MASNFNDIVKQG---YVRIRS---------RRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKKSERAASLSTVVPLPRSAYWQHITRQHSTGQLYHLQDVTSPLKLHRTETFPTYRSEH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P104-1", "uniprot_id": "DOK5_HUMAN", "id": "Q9P104-1", "name": "Docking protein 5", "aln": "MASNFNDIVKQG---YVRIRS---------RRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6A882-1", "uniprot_id": "A0A8I6A882_RAT", "id": "A0A8I6A882-1", "name": "", "aln": "MIPAVKPLGCDGAPDTIPTSSGVDTHMEIFKQSKIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQIECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDIQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKKSERAASLNTVVPLPRSAYWQHITRQHSTGQLYHLQDVTSPLKLHRTETFPTYRSEH", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . .: : :* : * :: **************************************************************************************:***********************************************************:******************************************************************************** *******.*:**********************:****:************:*****", "identical_positions": 279, "similar_positions": 15, "identity": "87.74%" }, { "cls_id": "homologset.agr.HGNC:16175", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BJ73-1", "uniprot_id": "RSPO4_MOUSE", "id": "Q8BJ73-1", "name": "R-spondin-4", "aln": "MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRREGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLPSCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEETASCRVLSESRKCPIKRLCPGERNPRQKN-RKDRRQRKDRKLER----RPHQRGSQ-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ACX0-1", "uniprot_id": "D4ACX0_RAT", "id": "D4ACX0-1", "name": "", "aln": "MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRREGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLPTCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEEMASCRVISESRKCPIKRPCPGERNPRQKN-RKDRRQRKDRKLER----RLHQHGSQ-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q2I0M5-1", "uniprot_id": "RSPO4_HUMAN", "id": "Q2I0M5-1", "name": "R-spondin-4", "aln": "MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**********:********* *****.***********:******************************:**** *:*******.************************:*:********:******:**.***** *** .***.**** ********.****:****** * :** *:*:*:********:* *****.* **: ***** ******:* * :* * * ", "identical_positions": 190, "similar_positions": 24, "identity": "81.2%" }, { "cls_id": "homologset.agr.HGNC:16176", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QY24-1", "uniprot_id": "ZBP1_MOUSE", "id": "Q9QY24-1", "name": "Z-DNA-binding protein 1", "aln": "MAEAPVDLSTGDNLEQKILQVLSDDGGPVKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSPEPATWSIGG-AASGDG----------------APAIPENSSAQPS--LDERILRFLEANGPHRALHIAKALGMTTAKEVNPLLYSMRNKHLLSY--DGQTWKIYHSRQEGQDIAHSGVTQESPAIICQHNPVNMICQQGANSHISIANSNAIQIGHGNVIVREKACGEPGPRTSH--PLPLAWDASAQDMPPVAHGAQYIYMDKSLLQQVQLGHHNEMSLVGDAGKHPSYSFSDSPPEVSTTTADPGASFNMQTFEPGPHPEGDTVQTVHIKSCFLEDATIGNGNKMTIHLRSKGEVMESGDSEEPKKEDTGTSSEATPPRSCQH-------TPSDSMLPTSELRAMALGDSSPQTTEPVLREHEVQDIESSQDTGLSKQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8VDA5-1", "uniprot_id": "ZBP1_RAT", "id": "Q8VDA5-1", "name": "Z-DNA-binding protein 1", "aln": "MAEASVDLGTGDNLEQKILQVLSDAGSPVQIDQLLKKLQVPKKILNQVLYRLKKEGRVSSPAPATWSLGGDGASGDG----------------APEIPEDSAAQPS--LEERILRFLETKGPQRALHIAKALGMTTAKEVNPILYSMRNKHLLTVS-DTQMWTIYRSSQEGQERACSGVGQESPAVIYQQNPINMICQQGPNSLISISNSKAIQIGHGNVMSRQTICGDPGPGTPHHAPLPVLEDAAAQDTPPGTHGAQLIHLNKSMLRRVQLGHGNEMNLERDPVEHPIFSFSSSPPE-STTTADPETAFNMQTPEPGPHPEGGTTQIVHIKSCLLEDTTVGNNNKMTIHRRSKGGTKESADSQE-LKEDTGASSEATPPRSCLH-------TPSDSTLLTSELTAMALGDGSPQITESMLREDEVQAAETCQTQD----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H171-1", "uniprot_id": "ZBP1_HUMAN", "id": "Q9H171-1", "name": "Z-DNA-binding protein 1", "aln": "MAQAPADPGREGHLEQRILQVLTEAGSPVKLAQLVKECQAPKRELNQVLYRMKKELKVSLTSPATWCLGGTDPEGEGPAELALSSPAERPQQHAATIPETPGPQFSQQREEDIYRFLKDNGPQRALVIAQALGMRTAKDVNRDLYRMKSRHLLDMDEQSKAWTIYRPED-------SGRRAKSASIIYQHNPINMICQNGPNSWISIANSEAIQIGHGNIITRQTVSREDGSAGPRHLPSMAPGDSSTWGTLVDPWGPQDIHMEQSILRRVQLGHSNEMRLHGVPSEGPAHIPPGSPPV-SATAAGPEASFEARIPSPGTHPEGEAAQRIHMKSCFLEDATIGNSNKMSISPGVAGPGGVAGSGEGEPGEDAGRRPADTQSRSHFPRDIGQPITPSHSKL-TPKLETMTLGNRSHKAAEGSHYVDEASHEGSWWGGGI---", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*..* . .:***:*****:: *.**:: **:*: *.**: *******:*** :** . ****.:** ..*:* *. *** ...* * :* * ***: :**:*** **:**** ***:** ** *:.:*** : : *.**:. : ** :*.::* *:**:*****:*.** ***:**:********:: *:. . : *. .: * *::: . . *.* *::::*:*::***** *** * . : * . ..*** *:*:*.* ::*: : .**.**** :.* :*:***:***:*:**.***:* * :...: **:* . * .** ***.* * *.:* :*:**: * : :* .*.. : . ", "identical_positions": 173, "similar_positions": 119, "identity": "39.23%" }, { "cls_id": "homologset.agr.HGNC:16177", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C1E1-1", "uniprot_id": "BPIB2_MOUSE", "id": "Q8C1E1-1", "name": "BPI fold-containing family B member 2", "aln": "MARACSLGLLLLLLLLLRTVVTVSLPVIVVRLNKAALDYVSDIGKAPLQRALQVTISDFMDPSGEVLQSTRVQILDAHVPFFYLKFIAGFGVHLSAAANFTIKVFSVPEPMELVLPVDLLADVHVARDSIGTLVLSVPACSSIFSPAGMLDGSISTSQELLDRVQEHIKADLNNKLCLHVYGLVQDLNVHLGTLIGLSPVGPESQIRYSITSMPTITSNYISLDIGAILSLLGKPILLPMHGAHPFVLPWPLGDAGAMATVGLSQHLFDCALLMLQKAGSLNLEITGQLNSKNNPLNTSVLGQLIPEVAHLFPEPTPLVLKVQLGATPVVTLHTSNSTLQLQPLVEVFAAPSNLALQFLFSLDVMVNLDLQLSVSKAKLRGSTSLLGGFQLSVATSNVGSVDMDQVLTLISTVFQKPLLDHLNALLGMGVVLPRVHNLHYVHSEVLVREGYVVVSSGLAYQH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A5H4-1", "uniprot_id": "D4A5H4_RAT", "id": "D4A5H4-1", "name": "", "aln": "MAGACSLG---LLLLLLQAVVTVSLPVIVVRLNKAALDYVSDIGKAPLQRALQVTISDFMDPSGEVLQSTRVQILDVHVPFFHLKFLAGFGVHLSAAANFTIKVFRVPEPMELVLPVDLMADVHVARDSIGTLVLSVPTCSSIFSPASMLDGSNSTSQELLDLVQEHIRADLNNKLCLHVYGLVQDLNVHLGTLIGLSPVGPESQIRYSMTSMPTITSNYISLNIRAILFLLGKPILLPLHDAHPFVLPWPSGDEEAMATVGLSQHLFDCALLMLQKAGSLNLDITGKLNSKNNPLNTSVLGQLIPEVAHLFPEPTPVVLKVQLGATPVVTLHTSNSTLHLQPFVEVFAAPPNLALQFLFSLDVMVNLDLQLSVSKAKLRGSTSMLGGFQLSVATSNVGSVDMDQVHTLISTVFQKPLLDHLNALLGMGIVLPSVLNLHYVHSEVLVREGYVVVSSGLSYQR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N4F0-1", "uniprot_id": "BPIB2_HUMAN", "id": "Q8N4F0-1", "name": "BPI fold-containing family B member 2", "aln": "MAWASRLG---LLLALLLPVVGASTPGTVVRLNKAALSYVSEIGKAPLQRALQVTVPHFLDWSGEALQPTRIRILNVHVPRLHLKFIAGFGVRLLAAANFTFKVFRAPEPLELTLPVELLADTRVTQSSIRTPVVSISACSLFSGHANEFDGSNSTSHALLVLVQKHIKAVLSNKLCLSISNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLLGKPIILPT-DATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDITGQLRSDDNLLNTSALGRLIPEVARQFPEPMPVVLKVRLGATPVAMLHTNNATLRLQPFVEVLATASNSAFQSLFSLDVVVNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFEKPLLDHLNALLAMGIALPGVVNLHYVAPEIFVYEGYVVISSGLFYQS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** *. ** *** ** .** .* * *********.***:*************:..*:* ***.**.**::**:.*** ::***:*****:* ******:*** .***:**.***:*:**.:*::.** * *:*:.:** : . *. :*** ***: ** **:**:* *.***** : .***.:**********.***********:.*:**:**:****:: *:* ******:** .* ***** * :********:***.***:*****:***:***:*.*.:* ****.**:******: **** *:****:******. ***.*:**:***:***:*:..* *:* ******:*** *******.**:*:**:**..**:**:**** :* *** **:.***:***********.**:.** * ***** .*::* *****:**** ** ", "identical_positions": 305, "similar_positions": 102, "identity": "66.02%" }, { "cls_id": "homologset.agr.HGNC:16178", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q05701-1", "uniprot_id": "BPIB3_RAT", "id": "Q05701-1", "name": "BPI fold-containing family B member 3", "aln": "MMPGVYALLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSLVGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGLFSLVEELSGLKIEELTLPTVSIKLLPGVGVQLSLHTKVSLHGSGPLVGLLQLAAEVNVSSKVALGMSPRGTPILILKRCNTLLGHISLTSGLLPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVPLGPLGSVEFTLATLPLISNQYIELDINPIVKSIAGDVIDFPKPRLPVKMPPKEDHTSQVTVPLYLFNTVFGLLQTNGALDLDITPEMVPRNIPLTTTDLAALAPEALGKLPPGQHLLLSLRVMKSPMILLQNKKVTVSIPVTIHVLSSVPQGTPVALFQMNGVMTLNAHLVPSTTKLHISLSLERLTVQLASSFSQPFDASRLEEWLSDVVRAAYMQKLNEHLEVGIPLPKILNVNFANSVVDVIENAVVLTVAP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80ZU7-1", "uniprot_id": "BPIB3_MOUSE", "id": "Q80ZU7-1", "name": "BPI fold-containing family B member 3", "aln": "MMLGVYTLLLLWGLATPCLGLLETVGTLARIDKDELGKAIQNSLVGGPILQNVLGTVTSVNQGLLGAGGLLGGGGLLSYGGIFSLVEELSGLKIEELTLPKVSLKLLPGVGVQLNLHTKVSLHGSGPLVGLLQLAAEVNVSSKVALGMSPRGTPILVLKRCSTLLGHISLMSGLLPTPIFGLVEQTLCKVLPGLLCPVVDSVLSVVNELLGATLSLVPLGPLGSVEFTLATLPLISNQYIELDINPIVKSIAGDVIDFPKPRIPVKVPPKEDHTSQVTVPLYLFSTVFGLLQTNGALDLDITPEMVPRNVPLTTTDLAALAPEALGKLPPAQHLLLSLRVTKSPMVLLQNKKATVSIPVTIHVLSSVPQGTPVALFQLNGVMTLNAHLAPSSTKLHISLSLERLSVQLASSFPQPFDASRLEEWLSDVVRAAYMQRLNEHLEVGIPLPKILNVNFANSVVDIIENAVVLTVAP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P59826-1", "uniprot_id": "BPIB3_HUMAN", "id": "P59826-1", "name": "BPI fold-containing family B member 3", "aln": "-MLALWSLLLLWGLATPCQELLETVGTLARIDKDELGKAIQNSLVGEPILQNVLGSVTAVNRGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKVLLKLLPGFGVQLSLHTKVGMHCSGPLGGLLQLAAEVNVTSRVALAVSSRGTPILILKRCSTLLGHISLFSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVSLGALGSVEFSLATLPLISNQYIELDINPIVKSVAGDIIDFPKSRAPAKVPPKKDHTSQVMVPLYLFNTTFGLLQTNGALDMDITPELVPSDVPLTTTDLAALLPEALGKLPLHQQLLLFLRVREAPTVTLHNKKALVSLPANIHVLFYVPKGTPESLFELNSVMTVRAQLAPSATKLHISLSLERLSVKVASSFTHAFDGSRLEEWLSHVVGAVYAPKLNVALDVGIPLPKVLNINFSNSVLEIVENAVVLTVAS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .:::*********** ************************** ********:**:**:****:**********.:**:*.:***************.* :*****.****.*****.:* **** ***********:*:***.:*.******:****.******** *******:**:*** * ***************.********.*.**.**.******:**********************:***:*****.* *.*:***:****** ******.*.***********:*****:** ::********** ******** *:*** *** ::* : *:***. **:*..**** **:*** :**::*.***:.*:*.**:************:*::****.:.**.********.** *.* :** *:*******:**:**:***::::*********.", "identical_positions": 359, "similar_positions": 84, "identity": "75.9%" }, { "cls_id": "homologset.agr.HGNC:16179", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q05704-1", "uniprot_id": "BPIB4_RAT", "id": "Q05704-1", "name": "BPI fold-containing family B member 4", "aln": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGDAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIEANDNTAQLGGKYRYGEILDSDGSLRDLRHEDYRPSDSAY--HRGPGRYRSAADPSSAGRLHRRELRPGEIPAGVATGALGPGGLLGTGGILANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAMLPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGALDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2BGH0-1", "uniprot_id": "BPIB4_MOUSE", "id": "A2BGH0-1", "name": "BPI fold-containing family B member 4", "aln": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAY--HRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P59827-1", "uniprot_id": "BPIB4_HUMAN", "id": "P59827-1", "name": "BPI fold-containing family B member 4", "aln": "MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQSDALHSALREVPLGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGKYRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAP----VGRLHRRELQPGEIPPGVATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKP-MPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** *********.**** ::*.**********.:**** :*:***::*******:***.:******** *** ****::*.* *:****::*** *************:*:**:****:..**..:.** *** ****:*. .***:****:*****.******:**********:** :******************************************************************************:****************************************************************:***************************:************************************.******* **: *:* ***********:****:*****.****:**** *:*:***:****:******:**************** ** ***** ***:* **********:**:**:****:*:***********::*****.***********:***************: ::*:****************:******************************:", "identical_positions": 525, "similar_positions": 69, "identity": "84.81%" }, { "cls_id": "homologset.agr.HGNC:1618", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P80316-1", "uniprot_id": "TCPE_MOUSE", "id": "P80316-1", "name": "T-complex protein 1 subunit epsilon", "aln": "-----------MASVG--TLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTITNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDKVLVDIN--NPEPLIQTAKTTLGSKVINSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVVD------AKIAILTCPFEPPKPKTKHKLDVMSVEDYKALQKYEKEKFEEMIKQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIELIAIATGGRIVPRFSELTSEKLGFAGVVQEISFGTTKDKMLVIEKCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q68FQ0-1", "uniprot_id": "TCPE_RAT", "id": "Q68FQ0-1", "name": "T-complex protein 1 subunit epsilon", "aln": "-----------MASVG--TLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDNVLVDIN--NPEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKEVLN------AKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIAQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIELIAIATGGRIVPRFSELTSEKLGFAGVVREISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P48643-1", "uniprot_id": "TCPE_HUMAN", "id": "P48643-1", "name": "T-complex protein 1 subunit epsilon", "aln": "-----------MASMG--TLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIK--DTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVED------AKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P40413-1", "uniprot_id": "TCPE_YEAST", "id": "P40413-1", "name": "T-complex protein 1 subunit epsilon", "aln": "MAARPQQPPMEMPDLSNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDEY", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *..:. :* ** ****:*:***..*.* **** ****:**::**. ::*****.****:::. **::*:********* *::*::****:*:********************.***::* :*:::*****:**:*:::**::**.:*:: .*.: .. . : *:::***:****::.. * ::**:**:**:.* * :*:****:***::*:*** :.*:***:***:*********** * .*:*******************: ***:*: **.**::**:*** ::*::**::.*****************.********* *:* ***:*.*******.:*: :*** .. : * .******:**:**:.*::::** *:**.****::**:*:***:***:***::*.**********:: :****:**** ::***:*.**:**:.***:*:****::** *:: ::::*:** . :*:*** *:***: .*::.:******* ****: *******:: .*:.* ", "identical_positions": 323, "similar_positions": 165, "identity": "57.47%" }, { "cls_id": "homologset.agr.HGNC:16181", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JLV2-1", "uniprot_id": "TP4AP_MOUSE", "id": "Q9JLV2-1", "name": "Short transient receptor potential channel 4-associated protein", "aln": "MAAAPAAAGAGASRGRRLAATAAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKLSKWSGIPQLLLKLYATSHLHSDFVECQSILKEISPLLSMEAMAFVTEDRKFTQEATYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQAPTVFPSLGTSEEGGLPHTSARAQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQV-DMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TEL6-1", "uniprot_id": "TP4AP_HUMAN", "id": "Q8TEL6-1", "name": "Short transient receptor potential channel 4-associated protein", "aln": "MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQV-DMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE---------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1P2D2-1", "uniprot_id": "A0A8M1P2D2_DANRE", "id": "A0A8M1P2D2-1", "name": "", "aln": "--MATRGPGFSRTQTRR------------GKP-CKNIFHKIRQGQVTGEGLTRGSQVPVALLEERDKRAQWQGIPVLLRRLHKSSHPNSDLSKIHSIVMELSSLLSMEAISFVTEERKMPQESISPNTYTFDLFGGVDLFMEILMRPTLTIQQNTPTMSDDLIKDCLSVLYNCCICTEGVTKSLAAREDFVMYLFTLMSNKKVFLQTATLIEDILSVRKEIIQLEEIPNLDSLVQSFNQQQLANFCRILSVTISEPDVGVDDKHTLLARSTQQKT--STCPSHAENNQVALLNIPGFIERLCKLATRKVTEAA-DASARLELEDWHSWLDNALVLDTLMQLAIEEAEQ-------SSTESSDESSLSSSPLRHRLPQSMKIVHEIMYKVEVLYVLCVLLMGRQRNQVHRMLAEFKLIPGLNNLFDKLIWRKQ-PFGHILHRQNQSCDCSPEISFKIQFLRLLQSFSDHHENKYLLLSGQELNELSDIYLNANIFEMEALNNTDRNLVCDGKKGLLTRLISVMKKEPIDSSFRFWQARAVESFLRGTPSYADQVFLLRRGLLEHILYCIIDSGCKSHDVLQSYFDLLGELMKFNIDAFKRFNKYVTTEEKFQMFLTQINSSLVDSNMLVRCIVLSLDRFENETNDVKVVEVFSECRLLSYMAQVENRLLFLLRLISIINVQTLTQENVSCLNTSLVILMLARRRGKLPLYLSALREKEYSEKYPGCLLNNFHNLLRFWQHHYLNKDKDSTCLENSSCIPFTYWKETVSVLLGSGRSSRCAIATYIDEPYRDLDRDFMELSLETERTLFTSQTHPACGYNS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. ..* . : ** *:* **: ::****:**.**.*. *.. ::* **** ::*.*** ** :*: :** :**: : :.*: *:*.******::****:**:.**: **** *********::*******::*: :. .:**:: *****:*** *:******* ** ::***::*****:.**.************.*:**:*:*:*:***.***..*:***********:***** *.* ********:.:***. * ** ** **.***.****:***********:*:: ** ***:*::*********:**::* **:*: .. :*:*..*. :. * :*******:******:*********************:********************: . . :** :**.*****:*::**********************..******* * *:*** *:**: ****.******:******:.****** :******************.*****:***:***********:** ***:*****************:*********:.*: ***:**.***************:.********:. *:**.**:******:*::** .:: **:***.**:************************: :***** *:. *:*:**** *************:***:**************.*:*******:**...*.* .*:.:**:*** *:**** * ", "identical_positions": 538, "similar_positions": 167, "identity": "65.69%" }, { "cls_id": "homologset.agr.HGNC:16183", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LY74-1", "uniprot_id": "A0ABK0LY74_RAT", "id": "A0ABK0LY74-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERSQSRLSLSASFEALAIYFPCMNSFDDEDAA-DSRRLKGAIQRSTETG--LAVEMPSR-------------TLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGVCIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P60191-1", "uniprot_id": "RIMS4_MOUSE", "id": "P60191-1", "name": "Regulating synaptic membrane exocytosis protein 4", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERSQSRLSLSASFEALAIYFPCMNSFDDEDAA-DSRRLKGAIQRSTETG--LAVEMPSR-------------TLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGVCIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H426-1", "uniprot_id": "RIMS4_HUMAN", "id": "Q9H426-1", "name": "Regulating synaptic membrane exocytosis protein 4", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERSQSRLSLSASFEALAIYFPCMNSFDDEDAG-DSRRLKGAIQRSTETG--LAVEMPSR-------------TLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F2S0-1", "uniprot_id": "E7F2S0_DANRE", "id": "E7F2S0-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERSQSRLSLSASFEALAIYFPCMNSFDEDDGDPEGRRLKG-IQRSTETG--LAVEMPSR-------------TVRQASHESIEDSMNSYGSEGNLNYSGMCLASDAQFSDFLDGMGPAQFVGRQTLATTSMGDVEISLMERSGQLEVEVIQARGLIMKPGSKGPPAAYIKVYLLENGICIAKKKTKSVRKSLDPLYNQVLVFSESPQGKVVQVIVWGNYGRMDRKCFMGVARILLEELDLSSMVIGWYKLFPTSSMVDPTMAPLIRHSSQLSLESTVGPCCERS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K6M2-1", "uniprot_id": "A0A0B4K6M2_DROME", "id": "A0A0B4K6M2-1", "name": "", "aln": "MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSE---EVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTN--IGLGSRRSSIASLDSLKL--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..* *:** :. . :.: *** . . . * * * *. .** *.*.: . : :.* ..:: : :*. .. : . .* .*. :.:*:..:**.*:****.*.:..:**:::.* .:.* ***::*:**** *. ** **.*:*.**:.. *: * **. .*::*****:* *:* :* * ::*: ***:***:::* *****:::*::*:*:.:.:****** *:*:*. . : .*: * :::.. ", "identical_positions": 91, "similar_positions": 105, "identity": "3.24%" }, { "cls_id": "homologset.agr.HGNC:16185", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60602-1", "uniprot_id": "ROMO1_HUMAN", "id": "P60602-1", "name": "Reactive oxygen species modulator 1", "aln": "MPVAVGPYGQ-SQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC----------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P60603-1", "uniprot_id": "ROMO1_MOUSE", "id": "P60603-1", "name": "Reactive oxygen species modulator 1", "aln": "MPVAVGPYGQ-SQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC----------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A742-1", "uniprot_id": "D4A742_RAT", "id": "D4A742-1", "name": "Reactive oxygen species modulator 1", "aln": "MPVAVGPYGQ-SQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC----------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NYD1-1", "uniprot_id": "ROMO1_DANRE", "id": "Q6NYD1-1", "name": "Reactive oxygen species modulator 1", "aln": "MPVSVGSYGQQAQPSCFDRVKMGFMMGFAVGMAAGAMFGTFSCLRIGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC----------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VUM2-1", "uniprot_id": "Q9VUM2_DROME", "id": "Q9VUM2-1", "name": "Reactive oxygen species modulator 1", "aln": "MPLPTSSFSQ-QGPTCFDKMKTGFIIGFCVGMASGAVFGGFSALRYGLRGRELINNVGKTMVQGGGTFGTFMAIGTGIRC----------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q02889-1", "uniprot_id": "MGR2_YEAST", "id": "Q02889-1", "name": "Protein MGR2", "aln": "MPPLPQNYAQ-QQPSNWDKFKMGLMMGTTVGVCTGILFGGFAIATQGPGPDGVVRTLGKYIAGSAGTFGLFMSIGSIIRSDSESSPMSHPNLNLQQQARLEMWKLRAKYGIRKD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :.* *: :*:.* *:::* **:.:* :** *: * :: :** : ..**** **:** **. ", "identical_positions": 27, "similar_positions": 22, "identity": "23.68%" }, { "cls_id": "homologset.agr.HGNC:16187", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4FZU9-1", "uniprot_id": "S52A3_RAT", "id": "Q4FZU9-1", "name": "Solute carrier family 52, riboflavin transporter, member 3", "aln": "-----------------------------------------------------------------------MAFLTHLLVCVFGMGSWVAINGLWVELPLLVTKLPEGWYLPSYLTVVIQLANTGPLLVTLMHRFRPGCLSEVPVIFLILCVGTTACILLAFLWSMTSWIQGRQHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLLPALVALVQGSGITTCVNVTETPGTTLNPVTTMETSITQRT---LSPSLT---PLTWHLESRYLAPRFSPLLFFLLLSFLMGCCLVAFFLLQRQPWGRQGSIEDLLHSQVTLHSIKP--RDTEDTGSVGAPVSSPGKGSVEVSVASLRPAQLAFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATLSSVASPLACFLPIFLPNRSLLFLGVLTVLGTGFGTYNMAMAAMSPCPILQGHWGGEVLIVLSWMLFVACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLKLFSSADYCSLDCSA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D6X5-1", "uniprot_id": "S52A3_MOUSE", "id": "Q9D6X5-1", "name": "Solute carrier family 52, riboflavin transporter, member 3", "aln": "-----------------------------------------------------------------------MAFLTHLLVCVFGMGSWVAINGLWVELPLLVTELPEAWYLPSYLTVVIQLANIGPLLVTLMHRFRPGCLSEVPVIFLILCVGTAACILLAFLWNVTSWIQGGQHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLLPALVALVQGSGITTCVNVTETPGTTLN---TMETPITQGN---LSPSLP---SPSWHQESRYLAPRFSPLLFFLLLSFLTGCCLVAFFLLQRQPWGRQGSIEDLLHSQVTLHSIRP--RDTEDTSSLGAPVSSPGKGSVEASVASLRPAQLAFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATLSSVASPLACFLPIFLPNRSLLFLGVLTVLGTGFGAYNMAMAAMSPCPVLQGHWGGEVLIVLSWVLFAACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLKLFSSADYCSLDCSV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NQ40-1", "uniprot_id": "S52A3_HUMAN", "id": "Q9NQ40-1", "name": "Solute carrier family 52, riboflavin transporter, member 3", "aln": "-----------------------------------------------------------------------MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTLLHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPVPTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFVLQRQPRCWEASVEDLLNDQVTLHSIRP--REENDLGPAGTVDSSQGQGYLEEKAAPCCPAHLAFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSLLFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVVLRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0S5Y3-1", "uniprot_id": "S5A3A_DANRE", "id": "B0S5Y3-1", "name": "Solute carrier family 52, riboflavin transporter, member 3-A", "aln": "-----------------------------------------------------------------------MPLYIHALACAFGLGSWVSINGLWVELPLIVNVLPEGWDLPSYLTVIIQFANLGPLLVTLAHKFCPGRLRENLAIYAVLSIGVVACILLAVFWNYTTVIFGQPRSTAFFILTFFLALVDCTSSVTFLPFMMQLPAKYITTYFIGEGLSGLVPGLVALAQGVGMSKCVNVTNVSDNVTDPG-----------------------PSTFIVETQYLPPNFSTEIFFSFLAVMTTISLGAFLILNRLPRTFELSTENLVSDSDAVATVCRGLEDPMDPKTNCPEEVEQKQNEVLLPKPQHSSYQLAFIYVMVLWVNSATNGLLPSVQTFSCMPYGNMAYHLSAALSAVANPVACIIAMFFPKRSLVFLGILCLLGSTFGGYNMAMAAMSPCPLLQDTPLGDAIIVLSWVFFTGLLSYVKVMVGVILRDRSHSALVWCGAAVQTGSLLGSIIMFPLVNVYHLFKSGDICNTNCPL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V9S9-1", "uniprot_id": "Q9V9S9_DROME", "id": "Q9V9S9-1", "name": "Riboflavin transporter", "aln": "MSRYHRGRGAGSPTNPAGPVYGVISTLDDATPSPADFARCSSLEAKKSELSLFLNWGGPQKNMEISSKLRNRSWLVDVLAIFFGIGTWLGVNGTFIQLPLLVDEAPEGWSLPSYLSVMVQIGNLGPLLYTAIQKYSPKKLNDGWTIHGVLLVGAISCLLTAFFYNQTASVAGTDHSLALFLLTCFTALNACTSSVLFMPYMGRFKEQYMVTYFIGEGLSGLLPSVTALIQGIGESGDCVLVNVTESGEE-----------------------------VYALRKTPPRFDTRVFFLILFALMVLAYVGYALLNSLPLAR---------------------REYAQVTVSEGNKYVYGEADNQPKAEKLSKGQYTYLLLLIGAISLFSNGMFGSIQSYSSAPYGSQAYHLAATLSVIANPVACFMAMFLHFTSLRIITVLSILAGLLTSYVFTTAALSPLPPLHDQTVGAVLVVTAWTLLVGIVSYTKLGITTVMRAQGGQSLVWVGAITQLGSAIGAVAIFFAINYSDLFQAAESNC-----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . *. **:*:*: :** :::***:* **.* *****:*::*:.* **** * ::: * * : *. :* :*. :*:: *.::. *: : . :* *:::** * ** ***** *:*:* :: *:.*:*:*******:*.:.** ** * : :.: . . . : ...*.. :** :* : . .: :*: * .: : : : ::: :: :. :**:: *:*::*. .** ****:*:** :*.*:*.::.:*: ** :: :* :*. : * :: *.:** * *:. * .::* :* :: . :**.*: : .::* . .:*:* ** .* ** :*:: :* :* **.:.: ", "identical_positions": 119, "similar_positions": 143, "identity": "21.96%" }, { "cls_id": "homologset.agr.HGNC:16188", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R184-1", "uniprot_id": "F110A_MOUSE", "id": "Q8R184-1", "name": "Protein FAM110A", "aln": "MPVDTLSPGAPATPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLVRQPLFSPGPRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEASRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGTTTTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERSLDRVPYGVSVIERNARVIKWLYGLRQARDPPTTEG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G4XVC3-1", "uniprot_id": "G4XVC3_RAT", "id": "G4XVC3-1", "name": "", "aln": "MPVDTLSPGAPTTPALPFRLRTKVPGYLLPRPADGGARKPSAVERLEADKAKYVKSLRVANTRQEPVQPPLARQPLFSPGSRGPVLTPSRRVLPCSGRRPQLDLDILSSLINLCDSPVSPSEANRTPGRPEGSAHKVPPATPPRPPPSTVAVRRVDVRPLPASPARPYPSPGAATTSSPGRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPCSSEGGCSRRSSATVEERTLERVPYGVSVIERNARVIKWLYGLRQARDPPTTEG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BQ89-1", "uniprot_id": "F110A_HUMAN", "id": "Q9BQ89-1", "name": "Protein FAM110A", "aln": "MPVHTLSPGAPSAPALPCRLRTRVPGYLLRGPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLSKQPLFSPETRRTVLTPSRRALPGPCRRPQLDLDILSSLIDLCDSPVSPAEASRTPGRAEG-AGRPPPATPPRPPPSTSAVRRVDVRPLPASPARPCPSPGPAAASSPARPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPGSSEGGCSRRSSVTVEERARERVPYGVSVVERNARVIKWLYGLRQARESPAAEG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***.*******::**** ****:****** **************************:*********** * :****** .* .*******.** . **************:********:**.*****.** * : ************ ***************** ****.:::***.************************************************************** ***********.*****: :********:*****************:.*::**", "identical_positions": 252, "similar_positions": 28, "identity": "85.14%" }, { "cls_id": "homologset.agr.HGNC:16191", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LQK9-1", "uniprot_id": "A0ABK0LQK9_RAT", "id": "A0ABK0LQK9-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "aln": "ACRELSDSPLTPGSPTVSIYAVFLRLLKVTQLGFFHTLVTVLERQVFDFLGYQWAPILANFAHIVVVILGLFGTIQYRPRYIVVYVVWAAVWVTWNIFIICFYLEVGGLSKDSELLTFSLSRHRSWWEEYGPDCLHEKAATAGLGALHGQSVVVGPGCGMVHSYVEALHSGLQILLALLGFVYGCYVVSVLTEEDDSFDFIGG-------------------------------------------FDPFPLYHVNEK---------------------------------------------------PS----------------------------------------------GLLSKQAYLPA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JMG4-1", "uniprot_id": "NKAI4_MOUSE", "id": "Q9JMG4-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4", "aln": "----------------MGFCSGRCTLLALCAL----QLVTALERQVFDFLGYQWAPILANFTHIIVVILGLFGTIQYRPRYIVVYVVWAAVWVTWNVFIICFYLEVGGLSKDSELLTFNLSGHRSWWEEHGPGCLHEEEATAGLGALHGQSLVVGAGCAMVHSYVEALHSGLQILLALLGFVYGCYVVSVLTEEEDSFDFIGG-------------------------------------------FDPFPLYHVNEK---------------------------------------------------PS----------------------------------------------SLLSKQAYLPA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IVV8-1", "uniprot_id": "NKAI4_HUMAN", "id": "Q8IVV8-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4", "aln": "----------------MGSCSGRCALVVLCAF----QLVAALERQVFDFLGYQWAPILANFVHIIIVILGLFGTIQYRLRYVMVYTLWAAVWVTWNVFIICFYLEVGGLLKDSELLTFSLSRHRSWWRERWPGCLHEEVPAVGLGAPHGQALVSGAGCALEPSYVEALHSCLQILIALLGFVCGCQVVSVFTEEEDSFDFIGG-------------------------------------------FDPFPLYHVNEK---------------------------------------------------PS----------------------------------------------SLLSKQVYLPA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A6MHQ4-1", "uniprot_id": "NKAIN_DROME", "id": "A6MHQ4-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "aln": "--------------MGSCSCTRRHFLLSICFL----QVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFYLNVGQLNRDSDLLNLGTG-SVSWFEANGYGCKPTYNMAADD-TFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILGAILISCIFLDEDDRFDFMNGDAKSPQHTVVHPMYVSYTSIPTTSASATMQSNKHLQLQHQQPQQNSLKLYHHQQQQQPKLHHFNKNYQLSGSNNNTLNNNLHQRAPALLPPNTTNNRSASFQTQSHPSNNHVTQRTGGEGSNCSSLRRHRQHHSKALVSPSPMSPQTTPSLSYASLQNSSPYLAGNSLSNSNYSIFQSPDSLQGSSHFARIHHKPKPPKSDYPVSGEFNPGGNISSPVRPLDRLSRSLEDDEDNFSLQKFAPGEHGVTYVPFQSPTPNSLFLGENNNSQPHLVFHTNSRSSPNNNAYPYDQSGLPSSLRMGSNSNARRPTHIPLPTVPMHNCQEVENDEDADGESEQDHDQMLTPPPPPLVRPHIHQRLGQAPYLDLSPEVAERYAIPSKLGPSLPIQVPLPVPHGSPMVRRSNRRPRPSNPVNFCDQIRATPPGYVVRAQSDDRLMEQVEADAAPHVNRRSGRGGSGQKTRPRSFCNSIVGVQG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *: : : ::: :********** *****.** **:.:*:*::*: ::* :*::.* :* :*: ** *:*****:** * :**:**.:. . **:. .* :.. : : * ** : . ** ** :* :****:: . : .:: :*:* ***:.* :.: *** ::: ** .* ... **.. ", "identical_positions": 72, "similar_positions": 68, "identity": "10.62%" }, { "cls_id": "homologset.agr.HGNC:16192", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P0DX21-1", "uniprot_id": "S17A9_RAT", "id": "P0DX21-1", "name": "Voltage-gated purine nucleotide uniporter SLC17A9", "aln": "-MPSQRSSLMQPIPEE-----------TRKTPSAAAEDKRWS-------------------------------RPECQLWTGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLG----SGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYLLD-EKDLVLALG---VLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPHSKGWVFNVVPWLLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKSMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTCVFHLVAIVSNLGLGTFLVFGKAQRVDLVPTHEDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCL5-1", "uniprot_id": "S17A9_MOUSE", "id": "Q8VCL5-1", "name": "Voltage-gated purine nucleotide uniporter SLC17A9", "aln": "-MPSQRSSLMQPIPEE-----------TRKTPSAAAEDTRWS-------------------------------RPECQAWTGILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLG----SGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLN-EKDLVLALG---FLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLVFGKAQRVDLVPTHEDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYT1-1", "uniprot_id": "S17A9_HUMAN", "id": "Q9BYT1-1", "name": "Voltage-gated purine nucleotide uniporter SLC17A9", "aln": "---------MQPPPDE-----------ARR---DMAGDTQWS-------------------------------RPECQAWTGTLLLGTCLLYCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLS----SAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLS-EKDLILALG---VLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHEDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G9P7-1", "uniprot_id": "A0AC58G9P7_DANRE", "id": "A0AC58G9P7-1", "name": "Voltage-gated purine nucleotide uniporter SLC17A9", "aln": "MADEQETGLFNPHEDVPFIKQCDCSTPGLQITQSSSKPTVWPRYDKHCLLKFIYLNIVHLCVDGTGIRHLERRRPLARTWTLMLLLVTCVLHWSRMAMPICAVTMAREFEWSKTETGMVLGAFFWGYCFTQVVGGHASDRIGGERVLLLSTSSWGIMTALTPILAKTG----LSPLLTMTASRFLLGVMQGVHYPSLVSICSQRVTEGERGLLMSTLACGCYLGMMLVGGVGSLMLDWFGWQSVFYGAGLLAVFWACCVWKCLLQ-GTDISLDSL---WISR-KDVSESSRINWLYLLREPSVWAMIIAHLCFSSSYYTLMSWLPTFFKDTFPHAKDWVFNVIPWFVALPTSLFGGSISDHLIRQGCGTAAVRKLMQFCSMGVASVFILFLCKTSSFIQAVACVSVTIGLSTFHNSGVSVNVNDQAPSCAGALYGVMNTCAAFTGLLMVYISGYMIEVTGSWVNVFSVLALVNVIGVAVFITLGEAKRIDQLDEPEII", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQZ7-1", "uniprot_id": "Q9VQZ7_DROME", "id": "Q9VQZ7-1", "name": "", "aln": "MDEKLKYSLLRG--------------------ELVDTQSIWT-------------------------------RHEKRVWFITLITGTCMLYSTRTTMPLLVPAVASAQKWSKTDSGTVLSSFFWGYTLTQVVGGYFSDRFGGQRVILFAAIGWSLITFLMPTIIWTAGSIKSYAIPFIVAIRILNGALQGVHFPSMISLTSQNLCPNERSSFFGLLTAGSALGTLLTGIMGSFLLDYFGWSYVFRVIGLMGIAWALVLRYYAMAGERNRIINIATPSRLCANKSPAETSAVPWLRYFRRLSFWACVLTHACEMNCFFVLLSWLPTYFHDGFPHAKGWVVNMIPWLALPPCTLFAKYLTTRLLAREWHTTTVRKVIQSCCFAAQNLALFVMSRTSDFHTALICMTIIIGGTGFHNNAVTVNPQDLAPLHSGSVFGLMNTVGAIPGFLGVYLAGHILELTQSWPMVFSAAAGINLVGWIIFIVFGSAEAIV--------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. . *. * : * *: **:*: :* :**: . ::: *.*.::* **.:***** :******: .**:**::*:*::: .*. :* * : . : :. *:* * :***::*:: *: **.: .**. . : .*. .* ::.* :**.:*: **. :* * : : *. : : : : :. :. . : * :*. :.** : :: . .:: *:*****:*.: **.:*.*:.*::**: * :**. :: :*: : . :***.:* :. .: : : :*:.* :: : ** *::..::** :* ** :* ::*: ** .*:.*.: * :.*:::* * ** :* * :. :* *:.:*.*: : ", "identical_positions": 112, "similar_positions": 154, "identity": "22.49%" }, { "cls_id": "homologset.agr.HGNC:16193", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CZJ2-1", "uniprot_id": "HS12B_MOUSE", "id": "Q9CZJ2-1", "name": "Heat shock 70 kDa protein 12B", "aln": "MLTVPEMGLQGLYISSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEARALQQASFSVVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGIFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKKMLALEVFAHALRFFKEHALQELREQSECMLEKGAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAASVYCRKLRLHQLMDLSSRTAGRGRLGERRSIDSSFRHAREQLRRSRHSRTFLVEAGVGELWAEMQEGDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNLVKWSSQGMLRMSCEAMNELFQPT-VSGIIQHIEMLLAKPEVQGVKLLFLVGGFAESAVLQHAVQEALGTRGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGHHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPEGCPENTG-TSPSRREIRAAMQFGDTEIKVTAVDVSTNRSVRAAIDFLSN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96MM6-1", "uniprot_id": "HS12B_HUMAN", "id": "Q96MM6-1", "name": "Heat shock 70 kDa protein 12B", "aln": "MLAVPEMGLQGLYIGSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEVRAPQQASFSVVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHALRFFREHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPT-VSGIIQHIEALLARPEVQGVKLLFLVGGFAESAVLQHAVQAALGARGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTEIKVTAVDVSTNRSVRASIDFLSN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q4KM45-1", "uniprot_id": "ADSSP_RAT", "id": "Q4KM45-1", "name": "Adipose-secreted signaling protein", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAANRGSKPR-------------VRSIRFAAGHDAEGSQ--SHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPAVR------------------------RLSKDIREAPVHSLHLKLLS----------------------------------------------------------VTPIPEGYSIKCEYSAHKEG----------VLKEEMLLACEGDIGTCVHVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD----------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * :* : *: : * **:.* : * *:: : :.:: :: *: *.:: . . *::: * :: * *: ::.:* . *.: *.:*. .:. * .:: .*.. : * *: : : .: .* :::: . . ..* . : : * :::.. . . ..* ", "identical_positions": 27, "similar_positions": 75, "identity": "3.93%" }, { "cls_id": "homologset.agr.HGNC:16196", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q32ZH1-1", "uniprot_id": "Q32ZH1_RAT", "id": "Q32ZH1-1", "name": "Beta-defensin", "aln": "MRLLLMALPLLALLPQVIPDYSAEKRCLNRLGHCKRKCKAGEMVMETCKYFQVCCVLDDNDYKQKASITRTMEKTST---IEYNLS-------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96PH6-1", "uniprot_id": "DB118_HUMAN", "id": "Q96PH6-1", "name": "Defensin beta 118", "aln": "MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:***:***:*.******* **.**:* ** ***:::** ** * :*** ::.**: .::*::: .: : * . ** *: *: ", "identical_positions": 41, "similar_positions": 26, "identity": "33.33%" }, { "cls_id": "homologset.agr.HGNC:16197", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZCD7-1", "uniprot_id": "D3ZCD7_RAT", "id": "D3ZCD7-1", "name": "non-specific serine/threonine protein kinase", "aln": "MAGASS---------EAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQG---------RAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLR-CRRAGIAAPVVFFVDYASNCLYMEEIEDSVTVRD---YIQSTMETK---QDPQCLLDLARKIGQVLARLHDEDLIHGDLTTSNMLLTR--PLEQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETVFEAFLKS--------YGASS-KKSDPVLKKLDEVRLRGRKRSMVG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3ZL21-1", "uniprot_id": "D3ZL21_RAT", "id": "D3ZL21-1", "name": "non-specific serine/threonine protein kinase", "aln": "MAAGSSEA-------ETEAEALAAAQERSRLFLSGLELVQQGAEARVFRGRFQG---------RAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLR-CRRAGIAAPIVFFVDYASNCLYMEEIEDSVTVRD---YIQSTMETK---QDPQCLLDLARKIGQVLARLHDKDLIHGDLTTSNMLLTR--PLEQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETVFEAFLKS--------YGASS-KKSSPVLKKLDEVRLRGRKRSMVG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PW4-1", "uniprot_id": "PRPKB_MOUSE", "id": "Q99PW4-1", "name": "EKC/KEOPS complex subunit Tp53rkb", "aln": "MAGTSS---------EAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQG---------RAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLR-CRRAGIAAPVVFFVDYASNCLYMEEIEDSVTVRD---YIQSTMETE---KDPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRR--PLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETAFEAFLKS--------YGASS-KKSSPVLKKLDEVRLRGRKRSMVG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96S44-1", "uniprot_id": "PRPK_HUMAN", "id": "Q96S44-1", "name": "EKC/KEOPS complex subunit TP53RK", "aln": "MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQG---------RAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLR-CRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRD---YIQSTMETE---KTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKP--PLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKS--------YSTSS-KKARPVLKKLDEVRLRGRKRSMVG", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QB90-1", "uniprot_id": "F1QB90_DANRE", "id": "F1QB90-1", "name": "non-specific serine/threonine protein kinase", "aln": "MAQTDS------------AKAAVPS------YLKEAQMIKQGAEARVYRSTFLG---------RSVIIKERFPKLYRHPEVDEKLTRRRTTQEVRSILR-CRRAGISAPVVYFVDYATHCIFLQDVVNSVSVRD---HIRS---------QPDGLQTLAERIGEVLAQMHDEDVIHGDLTTSNMLLTSGGQQQDFNLVLIDFGLSYISALPEDKGVDLYVLEKAFLSTHPKTEALFERLLKS--------YSSAS-KKSTAVIKKLDEVRLRGRKRSMVG", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VRJ6-1", "uniprot_id": "Q9VRJ6_DROME", "id": "Q9VRJ6-1", "name": "non-specific serine/threonine protein kinase", "aln": "---------------------------------MSLEILKQGAEGRLYLGDFKG---------EACLIKERFVKKYRHPELNTQITRQRMKAEAKASGR-CLAAGILAPKILHSDLNTHKLYMEYFDAAKTAKQ---FIQETVSTQTEDEAKKCLLEFCTRIGEIIGKMHSNHIIHGDLTTSNILINP--KGGDYDVILIDFGLSHYNQATEDKGVDLYVLERALLSTHSEQPYIFEHVLAA--------YRTACGKDEQAVLTKFEEVRARGRKRTMIG", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53323-1", "uniprot_id": "BUD32_YEAST", "id": "P53323-1", "name": "EKC/KEOPS complex subunit BUD32", "aln": "-----------------MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR--DGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEVRLRGRKRSMLG", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.****. :: . ::* * * **** :: : ::* * : : .*: .* : * . :::: . . . ::. . : :*. :. :* :. *****:**::: ******. . ***********:*:****.. :: : : *. * .:::*** *****:*:*", "identical_positions": 59, "similar_positions": 60, "identity": "21.07%" }, { "cls_id": "homologset.agr.HGNC:16198", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A438-1", "uniprot_id": "A0A8I6A438_RAT", "id": "A0A8I6A438-1", "name": "", "aln": "MEPESIEICPYNPHHRIPLSRFQYHLASCRKKNPKKAKKMASCKYNACHVVPIRKLAEHEATCVNRSSMEEEDALGPLQVSLPRP-QNEDTLQVR-WLSSPDIWNVD-GANCHPMFVLKS----FVPQKLVCESDIQESPGGDQCPEDPQTRTRKANF-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CWD0-1", "uniprot_id": "GTSFL_MOUSE", "id": "Q9CWD0-1", "name": "Gametocyte-specific factor 1-like", "aln": "MEPESIEICPYNPHHRIPLSRFQYHLASCRKKNPKKAKKMASCKYNACHVVPIRKLAEHEATCVNRSSVEEEDTLGPLQVSLPQP-QNQDTLQVR-WLSNPDIWNVD-GANCHPMFVLKS----FVPQKLVCESDIQESRGGDQCPEDPQTRTRKANF-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1H1-1", "uniprot_id": "GTSFL_HUMAN", "id": "Q9H1H1-1", "name": "Gametocyte-specific factor 1-like", "aln": "MEPEAFEICPYDPHHRIPLSRFQYHLASCRRKNPKKAKKMATCKYNACHVVPIKNLEEHEAVCVNRSAVEEEDTENPLKVSPPSSEQNDDTQQVSPCLPSPDIWNVD-GANCQHVFVLKT----FFPQKVVCENDTKESAR----ETSPQKILRPGQ------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8SWX0-1", "uniprot_id": "ASTRX_DROME", "id": "Q8SWX0-1", "name": "Gametocyte-specific factor 1 homolog", "aln": "-----MVYCPYNKEHKMLRKKLQQHILKCR-VIYKDTVELMVCPFNSSHLIPEPQFFQHTQSCEDRNIIVHYQTSAPAVLSEDTR--HAKIESEENWDDDESVPDYDPQVYCSRANIVREPNGLFPAQRRAFIEQEKRRHFGEDYEEEKKPRKAKARADLRPTPYEHRRPYSRRQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ***: .*:: .::* *: .** *.: :: * :*:.*::* :: :* * :*. : . :: * :* : . . . .: : * . * ::: * .*: . .: :. . : .. ", "identical_positions": 22, "similar_positions": 51, "identity": "12.57%" }, { "cls_id": "homologset.agr.HGNC:162", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QY83-1", "uniprot_id": "ACL7B_MOUSE", "id": "Q9QY83-1", "name": "Actin-like protein 7B", "aln": "MATKNSPSPKPMGTAQGDPGEAGTLPAPEAAGIRDTG-STQLKTKPKKIRKIKALVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDNFKETYVGHELLNMEASLKLVNPLKHGVVVDWDCIQNIWEYIFHTAMKIMPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAMHVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKF-SDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELHVDYELPDGKIITIGQERFRCSEMLFKPSLVGCTQPGLPELTATCLARCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDS-PTVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4QR76-1", "uniprot_id": "ACL7B_RAT", "id": "Q4QR76-1", "name": "Actin-like protein 7B", "aln": "MATKNNPSPKPMGTAQGDPGEAGTLPAPEAG-IRDTG-STQLKAKPKKIRKIKALVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDTFKETYVGHELLNMEASLKLVNPLKHGVVVDWDCIQNIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELMFETFGIPAMHVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKF-SDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELHVDYELPDGKVITIGQERFRCSEMLFKPSLVGSTQPGLPELTATCLDRCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDS-PTVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y614-1", "uniprot_id": "ACL7B_HUMAN", "id": "Q9Y614-1", "name": "Actin-like protein 7B", "aln": "MATRN--SPMPLGTAQGDPGEAGTRPGPDAS-LRDTGAATQLKMKPRKVHKIKAVIIDLGSQYCKCGYAGEPRPTYFISSTVGKR-CPEAADAGDTRKWTLVGHELLNTEAPLKLVNPLKHGIVVDWDCVQDIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAGHAF-TDDHLHIIEHIKKKCCYAAFLPEEELGLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSLAGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDS-PAVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGSVAIYSKC-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P45891-1", "uniprot_id": "ACTY_DROME", "id": "P45891-1", "name": "Actin-like protein 53D", "aln": "-----------------------------------------MSSEVDSNSHHAAVVIDNGSGVCKAGFSPEDTPRAVFPSIVGRP-RHLNVLLDSVIGDSVIGEAAARKRGILTLKYPIEHGMVKNWDEMEMVWQHTY-ELLRADPMDLPALLTEAPLNPKKNREKMTEIMFEHFQVPAFYVAVQAVLSLYATGRTVGIVVDSGDGVTHTVPIYEGFALPHACVRVDLAGRDLTDYLCKLLLERGVTMGTSAEREIVREIKEKLCYVSMNYAKEMDL--HGKVETYELPDGQKIVLGCERFRCPEALFQPSLLGQEVMGIHEATHHSITNCD-MDLRKDMYANIVLSGGTTMFRNIEHRFLQDLTEMAPPSIRIKVNASPDRRFSVWTGGSVLASLTSFQNMWIDSLEYEEVGSAIVHRKCF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. : . : *::** ** **.*:: * * .:.* **: . .. : :*. . .. *.* *::**:* :** :: :*:: : :: * : ..*:::.**.*..**** :*::** * :**::*: *::**:*: *:* *:**:**.**:*.*** ** ** *.* ** ***:** :** * * : :. . .*:..**:* **.:: :*:.* . ******: *.:* *****.* **:*** * *: * * .: .*: .::::* **::*.** **: .: .** ::*: :.* . * *:*:*: *******:**** :**::*:.. *:** *.. :: ** ", "identical_positions": 141, "similar_positions": 125, "identity": "33.41%" }, { "cls_id": "homologset.agr.HGNC:1620", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P80317-1", "uniprot_id": "TCPZ_MOUSE", "id": "P80317-1", "name": "T-complex protein 1 subunit zeta", "aln": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSK---EMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDE--PIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCG-DSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKY---KPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQ-----AEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZY35-1", "uniprot_id": "A0A8I5ZY35_RAT", "id": "A0A8I5ZY35-1", "name": "T-complex protein 1 subunit zeta", "aln": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSK---EMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDE--PIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIVELKKKVCG-DSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKY---KPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQ-----AEHSESGQLVGVDLNTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P40227-1", "uniprot_id": "TCPZ_HUMAN", "id": "P40227-1", "name": "T-complex protein 1 subunit zeta", "aln": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSR---EMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDE--PIDLFMIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKRKVCG-DSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKH---KPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQ-----AEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VXQ5-1", "uniprot_id": "Q9VXQ5_DROME", "id": "Q9VXQ5-1", "name": "", "aln": "MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPV---EINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVRAEREFIDQRVKKVIELKRSVCD-GTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAF---KDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLT-----VEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVMRAGMTSLKG---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39079-1", "uniprot_id": "TCPZ_YEAST", "id": "P39079-1", "name": "T-complex protein 1 subunit zeta", "aln": "-MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD-NLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. ****** * ** :*:::*.***.*:.********:****.***:**:****:*** ***** *** :**:.::***: ******: * ::****:**. ::.**:****:*:*** *:.::::.*::.*:. . ::: *::**.:** ***.. *:::** .:::*:: . : :**.*:*:*:*:* * .** :::***:***.***** .*:::**:* ********:********.:*::*: :. :**:*:: ::**:::**..**. ..** **:********:***.::*..*:************* *. ** * **.:**. : **.:*:**: .:**:*:*:: . .:* * *:*:**..:::::* ***:******: *.: * ::*****. : . * * **::: .::***:***:***.*. ***:* :.:. : .:. . . **:** *:. .. *::*.* * :: : ..: **:*:** **::*** ::** ", "identical_positions": 251, "similar_positions": 190, "identity": "45.8%" }, { "cls_id": "homologset.agr.HGNC:16200", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LF07-1", "uniprot_id": "A0ABK0LF07_RAT", "id": "A0ABK0LF07-1", "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "aln": "-----------------------------------------------------------MANENHGSPR--------------------EEASLLSHSPGTSNQNQPCSPKPVRLV----------------QDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSTLVETPPVENKPRKRQLSE--EQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPILKIWG-ASTEDKQ-------AALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEE-VEASELEPRLVYCYPVRLAVSAPPMPSVEMHMENSVVCIRYKGEMVK------VSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLY---EGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLSAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWGPTPERLQELTAAYK-----------------------QSGR---SHGSSSSSSSSSS--EAKDRDSGREQGPS---REPHPT-------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59114-1", "uniprot_id": "CAPAM_MOUSE", "id": "P59114-1", "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "aln": "-----------------------------------------------------------MANENHGSPR--------------------EGASLLSHSPGTSSQSQPCSPKPVRLV----------------QDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSSLVETPPVENKSRKRQLSE--EQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPTLKIWG-SSTEDKQ-------AALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPDVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAVLKENNIPEE-VEASELEPRLVYCYPVRLAVSAPPMPSVEMHVENSVVCIRYKGEMVK------VSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLY---EGTGLQGSLPVHVFETLHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSAEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNGPGFAKWGPTPERLQELTAAYK-----------------------QSGR---SHGSSSSSSSSSSSSEAKDRDSGREQGPS---REPHPT-------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H4Z3-1", "uniprot_id": "CAPAM_HUMAN", "id": "Q9H4Z3-1", "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "aln": "-----------------------------------------------------------MANENHGSPR--------------------EEASLLSHSPGTSNQSQPCSPKPIRLV----------------QDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSE--EQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWG-TSPEDKQQ------AALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEE-VEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVK------VSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLY---EGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYR-----------------------QSGR---SHSSGSSSSSSSE---AKDRDSGREQGPS---REPHPT-------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IKJ1-1", "uniprot_id": "CAPAM_DANRE", "id": "A0A0R4IKJ1-1", "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "aln": "-----------------------------------------------------------MTSENHTTIK--------------------ADSALVMSPTGSTSQAAPFSPSTSKPI----------------QELPDELIQAGWSKCWSKRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNAAPASGEANADAG--LGNGQRKRHPSEDASQAGPNSFKRPKVEIPATPTTPTVPISPSTPG---VKPWVNTTTDEKQGQASTPAPAPYRPSVVYWDLDIQTNAVIRERAPADHLPPHPEIELQRAQLTTKLRQHYHELCSQREGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIPIRLSRIKYKEEARKLLFKYAEAAKKMIDSRNATPESRKVVKWNVEDTMNWLRRDHSASKEDYMDRLEHLRKQCGPHVASVAKDSVEGICSKIYHISAEYVRRIRQAHLTLLKECNISVDGTESAEVQDRLVYCYPVRLSIPAPPQTRVELHFENDIACLRFKGEMVK------VSRGHFNKLELLYRYSCIDDPRFEKFLSRVWCLIKRYQVMFGSGVN---EGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFCSAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEELMDAMVTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTRMEASRFRRHQMTVPAFEHEYRSGSQHICKREEIYYKAIHGTAVIFLQNNAGFAKWEPTTERIQELLAAYK-----------------------VSGRSLPSPGPSSTNTGEKDSKPAPERTAPSQDNSSPVDKTAQDTTNT----------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VPB7-1", "uniprot_id": "Q9VPB7_DROME", "id": "Q9VPB7-1", "name": "", "aln": "MAANNNNSIIHNLGAGTEGLLSSVIASTGTPGMGSSPVPSRASSSSASSAAQSAWDQLTASASNNMSPSPTAGAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGPPTLGPGGYGEELTAELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGICHAGGP-------TPIIPNMHQQQQHQH------HHLKRRPSDDMHIHPNQHHMGGGP------PMKKFV----------LAGP-----------WDLEVCTNAVIVERPPTLLPQPHPEVEALRAAFTMKLLKTYEDLCMRRENIKAPRDSFNRWLMERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIPIKIVKPKFTGDARKQLSRYAEAAKQIIESRSAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDRLAHLKRQCEPHLVETVKSSVETLCVKIYHLSADHARKIRERHSQLLKEHGIPEPTPPPPPPHLKKVWCYPIQFAVPSPRMPTIEYLQDRDHMIIKYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKKFDLFIGRVWCLLKRYQTFLGNALNSSQEAELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQYCSAFADTDAYFGSRGPFLDFKPVSGSFQVNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPEWKS-----ISKLDDSMYKRRSMVVLGMAHEYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRPQRDRERERAAAAAAAAGVTSSQQSPSTPPSAASTAPTTNSCTISGVNSNSSSTATTTSTSSSPSLTTTSSSMSPLSPHTPTGNPPPQFPMTISNTSSSSNLVAASPTMSVQSDCSSPSSSTMSLSPAPASGGYPDGVTSATAAAVSITATTTTSAAGAGSAFGQANSISSSASTQAVINSAV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .*: : :: : ...:. . :*.. . : ::*. **:: ** * **:**.****:*:.*.:****** .* ::****: : . * :::: .. : ::*. :: *. : .* :* : ***:: ***** .* *: ***::* *: : ** : *.:** :**.*:.**:*****::****:*.* ******.* * :*.**:****.****:: : *: :*:: * :*****:::*:**.*..:*:**********:.***: .** **: *** **::** **: ..*.*** :* ****:* ::.::**: * :*** .*. .. . : *:***:::::.:* . :* :.. :::. :: :. ::.** ***:.*.** *: *: *****::*** ::* .: *. *.:*** *** *:: ***:*******:*.**:*:****.* *.:****** *.* * ****:.***.****::* : *:: ** : ******:*:***:. ::::: * ::*:.: : .: **** * **: ::.:: *.::.* *::***..*:*:* *. *:: * *:: * * .. :..:.. . .. : .* . * ", "identical_positions": 259, "similar_positions": 231, "identity": "26.84%" }, { "cls_id": "homologset.agr.HGNC:16203", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63471-1", "uniprot_id": "BPIA2_RAT", "id": "Q63471-1", "name": "BPI fold-containing family A member 2", "aln": "MFQLGSLVVLCGLLIGTSESLLGDVANAVN------------NLDILNSPSEAVAQNLNLDVGSLQQATTWPSAKDSILETLNKVELGNSNGFTPLNGLL-LRVNKFRVLDLQAGLSSNGKDIDLKLPLVFEISFSLPVIGPTLDVAVSLDLLNSVSVQTNAQTGLPGVTLGKCSGNTDKISISLLGRRLPFVNRILDGVSGLLTGAVSILLQNILCPVLQYLLS-TMSGSAIQGLLSNVLTGQLAVPL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P07743-1", "uniprot_id": "BPIA2_MOUSE", "id": "P07743-1", "name": "BPI fold-containing family A member 2", "aln": "MFQLGSLVVLCGLLIGNSESLLGELGSAVN------------NLKILNPPSEAVPQNLNLDVELLQQATSWPLAKNSILETLNTADLGNLKSFTSLNGLL-LKINNLKVLDFQAKLSSNGNGIDLTVPLAGEASLVLPFIGKTVDISVSLDLINSLSIKTNAQTGLPEVTIGKCSSNTDKISISLLGRRLPIINSILDGVSTLLTSTLSTVLQNFLCPLLQYVLS-TLNPSVLQGLLSNLLAGQVQLAL-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63550-1", "uniprot_id": "Q63550_RAT", "id": "Q63550-1", "name": "", "aln": "MFQLGSLVVLCGLLIGTSGSLF----------------------DIFQNP--------ELDVES-----VWSEINYRIRYALETMDLDMLADYLSKRGIE-LKIKDLRILNLNHEVSPNGDEVTLKMPMALNASLSLPARDLTTDVSISMEAITSFAIEKDPKTGRRVLNMQRCSLNTDNTSISLLNRKSNFVNLALDSALYLIKRGLTLPVRRQLCPVLQLIISNTFHPDEISNPQTAIST--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96DR5-1", "uniprot_id": "BPIA2_HUMAN", "id": "Q96DR5-1", "name": "BPI fold-containing family A member 2", "aln": "MLQLWKLVLLCGVLTGTSESLLDNLGNDLSNVVDKLEPVLHEGLETVDNTLKGILEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVISKLLPTNTDIFGLKISNSLILDVKAEPIDDGKGLNLSFPVTANVTVAGPIIGQIINLKASLDLLTAVTIETDPQTHQPVAVLGECASDPTSISLSLLDKHSQIINKFVNSVINTLKSTVSSLLQKEICPLIRIFIH-SLDVNVIQQVVDNPQHKTQLQTLI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:** .**:***:* *.* **: . .: . ::*: * : : : : . .: *::.. :*:.: :*. : *..*:. : :. * . :: *:: :.:.:::.:.:* : .*: :. . *:***.:: ::* ::.. :. :: ::. :**::: .: :: . :. ", "identical_positions": 31, "similar_positions": 88, "identity": "12.4%" }, { "cls_id": "homologset.agr.HGNC:16204", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZJA2-1", "uniprot_id": "D3ZJA2_RAT", "id": "D3ZJA2-1", "name": "", "aln": "-MHLLWRFLVLLLGLLALPSALPKQPWPGLTKAHKDGRSTLARIIAQGLLKHNAEGRIQSMRLLDRLNVSGTVAPGMVSWLISGMNFQQQQEISINITNVQLDCGGIQMAFPKEWFSANITLEFDIEFKLPFNSNILKTHAQMGLAAESWLEKDEFGRRKLVTGRCQMEPSSDSASMTTEAASPKMKNFLHNLRESLGKVIPNLVESQVCPLIGEILRQLDVKLLKGLVEQVAAHN-----LGQP----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D9J8-1", "uniprot_id": "BPIA3_MOUSE", "id": "Q9D9J8-1", "name": "BPI fold-containing family A member 3", "aln": "-MHLLWRLLVLLLGLLALPSALPKQPWPGLTKAHKDGRSTLARIIAQGLLKLNAEGRIQSMRLLDRLNVSGTVAPGMVGWLIGGMNFQQQQEISINITNVQLDCGGIQMAFPKEWFSANITLEFDIEFKLPFNSNIIKTHACMGLTAESWLEKDEFGRRELVMGRCRMEPSSGGASMSTEETSPKMKHFLHNLRESLGKVIPNLVESQVCPLIGEILRQLDVKLLKGLVGACS----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BQP9-1", "uniprot_id": "BPIA3_HUMAN", "id": "Q9BQP9-1", "name": "BPI fold-containing family A member 3", "aln": "MMCPLWR-LLIFLGLLALPLAPHKQPWPGLAQAHRDNKSTLARIIAQGLIKHNAESRIQNIHFGDRLNASAQVAPGLVGWLISGRKHQQQQESSINITNIQLDCGGIQISFHKEWFSANISLEFDLELRPSFDNNIVKMCAHMSIVVEFWLEKDEFGRRDLVIGKCDAEPSSVHVAILTEAIPPKMNQFLYNLKENLQKVLPHMVESQVCPLIGEILGQLDVKLLKSLIEQEAAHEPTHHETSQPSACQAGESPS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *** *:::******* * *******::**:*.:***********:* ***.***.::: ****.*. ****:*.***.* :.***** ******:********::* ********:****:*:: .*:.**:* * *.:..* **********.** *:* **** .:: ** .***::**:**:*.* **:*::************* ********.*: : ", "identical_positions": 149, "similar_positions": 53, "identity": "58.43%" }, { "cls_id": "homologset.agr.HGNC:16205", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CXC3-1", "uniprot_id": "MGME1_MOUSE", "id": "Q9CXC3-1", "name": "Mitochondrial genome maintenance exonuclease 1", "aln": "--MKLPLTFCRLLSRLNRFSVKASPPVSFSTFSYLCSQKKK-NSYEAVDQAKYSRLVRSVLS-RGPAQTPESLFKEDDVLYGPVSKHKAAEPEPQARVPQHCFPIFNEERTGKPHTDASSSPLKIPLQRNSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQENLTGGEE-HPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPLIRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTEKQKNLSAPEPA---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BQP7-1", "uniprot_id": "MGME1_HUMAN", "id": "Q9BQP7-1", "name": "Mitochondrial genome maintenance exonuclease 1", "aln": "MKMKLFQTICRQL-RSSKFSVESAALVAFSTSSYSCGRKKKVNPYEEVDQEKYSNLVQSVLSSRGVAQTPGS-VEEDALLCGPVSKHKLPNQGEDRRVPQNWFPIFNPERSDKPNASDPSVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** *:** * * .:***:::. *:*** ** *.:*** *.** *** ***.**:**** ** **** * .:** :* ******* .: : ****: ***** **:.**::. .* ********* ******:*****. :* *:*****:**:******** ***********:**:**********.*. :* :.*****:****.::***:*********:*:*:*********:****************:*:.*:************:***::************************** ****:**:************:** . :* ", "identical_positions": 241, "similar_positions": 60, "identity": "69.65%" }, { "cls_id": "homologset.agr.HGNC:16207", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P86411-1", "uniprot_id": "RGPA2_RAT", "id": "P86411-1", "name": "Ral GTPase-activating protein subunit alpha-2", "aln": "MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDASDLKQFFETNYSQIYFIFYENFITLENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVL----SSRGPCTLETLIN-PSPSVV------------DAKIYPEEITPLLPAVSGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTG--FKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLEIPHLRPKPLYVTVTRDNETIYSTKIPYMAARVVFIKWIVTFFLEKKYLT-ATQNTKNGVDVLPKIIQTVGGGAI-QEKVPELDGAGATEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRTVYEMVQRILLSTRGYVNFVNEVFRQAFLL---PSCEISITRKVVQVYRKWILQNKP-VFMEEPDKKDVAEEDADKLGLSETD-SKEVSSESSGHKRSSSWGRTYSFTSAMSRGCVTEEDNTNVKAGAQAMLQVFLTNAANVFLLEPC-----------VEVPMLLREQVDACKAVLIIFRRMIMELTMNQKTWEQMLQILLRITEAVMQK-----PKDKLVQDSFARSLAGLLFRTLIVAWIRANLCVYISRELWDDFLRVLSSLTEWEELITEWSNIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLEPQKGTAVGRSFSLSWRSHPD---VTEPMRFRSATTSGAPGVEKARNTVRQKATEVEEFQ----QAESTAAADCDYLVVG----------------------------------QQP-VPRSSSTSDITERLYSDSSQGQKVENSQNLSSSEPKSVQESKGHVTHEHEGVTILVRRSSSPAELDLKEESQQTHGRCRERQKSESTGSDMAVGYSNEAELPVSPWQTCEEDPE------LSTPTDAVADSDARHWLQLSPTDASN---------------------------------LTESRECLADDCSIIAGGNLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHAKVFSYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPPLRMFASWLFKATTLPNEYKEGKLQAYKLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVLNTIIKNCS-PRFFSLGLPGFSMLVGDFITAAARVLS--TDMLAAPRSEALTLLGSLVCFPNTYQEIPLLQSVPEVSDVVTGAEDVKHYLINILLKNATEEPNECARCIAICSLGVWICEELAQ----------------------------CASHPQVKDAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSALLHPVSTAVIEELHPSRAPLLDYIYRVLHCCVCGSSTYTQQSHYTLTLADLSSTDYDPFLPLANVRNSEPVQYHSSA-DLGNLLTVEEEKKRRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHDN---------AHVEGTELSSEVFRSPNLQLFVFNDSTLISYLQTPAEG----PAGGTSGGSLSDVRVIVRDISGKYSWDGKVLYG-------------PLEGR--LAPSGRNPS----FQISGWHHHTCGPQSNLFHGEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSPTPSAMNCDQEKE--------IIEVILRQSTQEDEYVQRCHS-NSAVKVTSQG---------QPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFITITKKPEVPFFGPLFDGAIVSGKLLPSLICATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD-------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A3KGS3-1", "uniprot_id": "RGPA2_MOUSE", "id": "A3KGS3-1", "name": "Ral GTPase-activating protein subunit alpha-2", "aln": "MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDASDLKQFFETNYSQIYFIFYENFITLENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVL----SSRGPCTLETLIN-PSPSIV------------DAKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTG--FKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLEIPHLRPKPVYVTVTRDNETIYSTKIPYMAARVVFIKWIVTFFLEKKYLT-ATQNTKNGVDVLPKIIQTVGGGAI-QEKVPELDGAGSTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRTVYEMVQRILLSTRGYVNFVNEVFRQAFLL---PSCEISVTRKVVQVYRKWILQNKP-VFMEEPDKKDVAQEDADKLGLSETD-SKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEDNTNVKAGAQAMLQVFLTNAANVFLLEPC-----------AEVPMLLREQVDASKAVLIIFRRMIMELTMNQKTWEQMLQILLRITEAVMQK-----PKDKHVKDLFAQSLAGLLFRTLIVAWIRANLCVYISRELWDDFLRVLSSLTEWEELITEWSNIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCILEPQKGTAVGRSFSLSWRSHPD---VTEPMRFRSATTSGAPGVEKARNTVRQKATEVEEFQ----QAESTAAADCDYLVVG----------------------------------QQQ-VPRSSSTSDITERLYSDSSQGQKVEHSQNLSSSEPKSVQESKGHVTHEHEGITMLVRRSSSPAELELKDDLQQAHGRCRQRQTSESTGSDTVVGYSNEAELPVSPWQACEEDPD------LSTPTDAVADSDARHWLQLSPTDASN---------------------------------LTDSRECLADDCSIIAGGNLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHAKVFGYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPPLRMFASWLFKATTLPNEYKEGKLQAYKLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVLNTIIKNCS-PRFFSLGLPGFSMLVGDFITAAARVLS--TDMLAAPRSEALTLLGSLVCFPNTYQEIPLLQSVPEVSDVVTGAEDVKHYLINILLKNATEEPNECARCIAICSLGVWICEELAQ----------------------------SASHPQVKDAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSALLHPVSTAVLEELHPSRAPLLDYIYRVLHCCVCGSSTYTQQSHYTLTLADLSSTDYDPFLPLANVRNSEPIQYHSSA-DLGNLLTVEEEKKRRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHDN---------AHVEGTELSSEVFRSPNLQLFVFNDSTLISYLQTPAEG----PAGGTSGGSLSDVRVIVRDISGKYSWDGKVLYG-------------PLEGR--LAPNGRNPS----FQISGWHHHTCGPQKDLFNGEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSPTPCAMNWDQEKA--------IMEVILRQSAQEDEYVQRCNS-DSSVTVTSQG---------QPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFITITKKPEVPFFGPLFDGAIVSGKLLPSLICATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSVSGTD-------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q2PPJ7-1", "uniprot_id": "RGPA2_HUMAN", "id": "Q2PPJ7-1", "name": "Ral GTPase-activating protein subunit alpha-2", "aln": "MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYENFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVM----SSRGPCTLETLIN-PSPSVA------------DVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTG--FKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAARVVFIKWIVTFFLEKKYLT-ATQNTKNGVDVLPKIIQTVGGGAV-QERAPELDGGGPTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLL---PSCEIAVTRKVVQVYRKWILQDKP-VFMEEPDRKDVAQEDAEKLGFSETD-SKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPC-----------AEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQK-----PKDKQIKDLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPD---VTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQ----QSENAPAAGSGHLTVG----------------------------------QQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPE------LNTPTDVVADADARHWLQLSPTDASN---------------------------------LTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCP-PRFFSLGFPGFSMLVGDFITAAARVLS--TDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQ----------------------------CTSHPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSA-ELGNLLTVEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDN---------AHVEGSELSFEVFRSPNLQLFVFNDSTLISYLQTPTEG----PVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYG-------------PLEGC--LAPNGRNPS----FLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKE--------IIEVILRQNAQEDEYIQSHNF-DSAMKVTSQG---------QPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD-------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R8QI48-1", "uniprot_id": "A0A2R8QI48_DANRE", "id": "A0A2R8QI48-1", "name": "", "aln": "MFTRRVYGDVKKSTQKVLDPKKDVFTRLKHLRALLDIIDRNELKAFFETNCSQIYFIFYENFITLESNLKQKGN-KSQREELDSILFIFEKILQLLPEKINSRWQYHSIGSILKKLLHTGNSFKIRCEGMRLFLLWLQALQNHCAEEQLLIFACLIPGFPAVP----SSRGPCTLDTIIYNPFSNPP------------DAKIVPEEITPLVPAVPGEKVADDHTCSVLQIVLKVIVLQASSLDWKNKENQDTG--FRFLFSLFKKYYLPHLFPTFSKHTNLYKPQLDLPIHRPKPLYVPVTRNNESTYCTRDQYLAPRVAFITWLVNFFLEKKYVNSTTSNSKNGGEVLPKLIQTVTAGSISQEKSTDLEPNGPVEQEKNHSNSSTLSDRRGSNSSLCSIEEEHRGVYDMVQAILLSTRDNVNFVNEVFHQAFLL---PSCEASATRKVIKVYRKWILQEKP-AFMAEPETTNQEEDTEEEQLVTETDNAHIQALETHGHKRSSSWGRTYSFSSAISRGCLTEELNLEVKAGIQSALQVFLTNSANVFLLEPC-----------QDVPKLLENQLEVCRAVLSVYRHIIMEQNMNRQTWEQLLQVLLRITEAVMKR-----PQENQKKDTFAHSLASILFKTIFVAWVRANLTVFISRELWDELLAVLSSLSHWEELVFEWASIMDSLTAVLARHVYGLDLHNLPLDKLSEQKEKKQRGRGVMADSHKVSEAGRSFSLSWKNSGDQVGAQEPMRFRSATTTGTPAVEKARNNVRQKAKRSQSISNCVHLCEALPATKSVPMLLHTVSSFLPGISHNSHCSHRLSDVEECQLSECEMGDGDSPLPRSSSTSDITQQIN-DTFTGQRKDESMDLVRS---SVSESSSAGTRESDAPVILIERSNSPADLDYPAEGAPAFLKMKLREKSESVSSETSNGYLNEAEVGLLSWHTLEEEPDSPSTQDVSMSMSVTADTVSQRSLLLSHTEALAGSPHFPPVSPALLVPHGCCEGPQLLEDAMNMPQHLDSSEFLADDISIIAGGSLTGWHADSAFVLWRRILGILGDVNSIRCARIHAKVFSYLYELWHKLAKIRDNLGIRVDSDTAMVKPLFIPPLRMLASWLFKATMLPSEFKAGKLQAYKLICEMMTKHQDVLPNSDFLVHLYHVMHKGFTSDDQDVLNTMIRWCS-PRFFFLGLPGFTMLVGDFITAAARILN--TDSFEAPRVEAQAVLGSLVCFPNLYQQIPSLQSVPGSEDILVGKEDMKDYLVNILLKTARSETCEGARCVAICGLGLWVCEELRQ----------------------------TETHHQVKDAINVLGVTLKFGNKVVANVACDIFQLLISHWQHLQRLEPSLPKRIIEIFVATVAFLLPSAEHSTVEADKKLMVSLLLCLLDWCMSVPLSILLEPITMPVLDDPTSQKAPLLDYIYRVLHTCVSGSNLHTQQSHYLLSLADLS-TDYEPFLMLGNVKSFEPPAIHNAMGDFGNLLTVAEEKKRRSMELIPLTARMVMTHLVNHLGHHPLSGGPALLNSLISENHDN---------PYVESSELSSEVFKSPNLQLFVFNDSTLISYLQIPSDNSNTAPLSANPRDHSSEVRIIIRDISGKYSWDSGVLFR-------------TLDGTGVTSSDSREQSSHEAARLEKRSSVRFSKCSSELDVEDGVDVLDQLLEDLGHSSPECLPEPQLRLTQPPSPPMGMNLEIEGL--------IMEAVHRQSKQEEEELMRRQIEDPSVRAERQK---------EPTHQEPKSPFYLCRLLLNDLGMNSWDRRKSFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIGEGQEDKYSILSNTQGSQVYEDFVSGLGWEVNLATHCGFMGGLQRNGSTGSTAPYYATSNVEVIFHVSTRMPSDSDDSITKKLRHLGNDEVHIVWSEHTRDYRRGIIPTDFGDVLVIIYPMKNHMFFVQIMKKPQVPFFGPLFDGAIVTGELLPSLVRATCINASRAVKSRLPLYQSFYEERALYLEAIIQNHKENMTFEDFAAQVFSPSPSYWPSGGAGSLSCSTSADLSVSVMTNDSGDQVSPTIPRATKNRVSGKLRRSASAISKSSN---------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VB98-1", "uniprot_id": "Y5521_DROME", "id": "Q9VB98-1", "name": "Probable Rho GTPase-activating protein CG5521", "aln": "MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQAEANLKQKVH-KAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKLRREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGMASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKDHRAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMR--------------SINKKEEVMASCVVVLINWVSRFTHERLLS--------------------------------------------HRLDCTLHIEDVDQVRLHGYQQG-----LIVRDVLYVNRENINFVHEVYRQAFLLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPN-------------------DDPPPPSNAGGTPRSQRLRTPSYVGAIAG----SKDQLVVRAGRQNVLQVFVTNAANVFLVNTANLNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSGTNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIGSVWQGSGSNSAANGGSAASAAISQ-----NRQRESLAESSSSRSEETSSQVPLPNHPRPHHQHT---QSQGGTGHGTRPIPLT------------------------------------PMLSRSYSEGSLASAARSSRIRRRRAATPKPKALQPSQLAENRINPQDLRRAMSLDSLARKGDAEETDSYQEGDNESGAGS-RSPSPTASSGIEGGSIKDAQLQID---------------------ASLDDANSGSYGSGSNSGSIS------------------------------------------GRRCIILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQG---AVNMQQLPLFYHALHQLLTGEDRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYPSSLLTRSVLQPTPQKFELMECS-DLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERGRQLAAIERVP----QLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPFN--------EQGDTLVLQVLRVLLQVASGAPRHER-------VKLTADDDFDMHIAHDDLQGDG---------RLPEATYQTSETIQKCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVELPSVVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQG-CGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAGSTAAMEAATGMSSASPRGPRKLGAPFKSVTKKHSLQHIAVGGGAGAGGDTPPESPTLPQRRFK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::: :.****** *: *.*** :**:*** :** :: .: * :**** *::***:*:.** * .** * : *::*****. *:::**** :*** : **: :*:. : **** *** *:* **:* **** *:* :.. ::* *:**: . .. : . :: * . . : ..*:..*:*. ..** * .. *:::*: :* *:.* *:::. *. * **: * . :** : *.* .:*:* *::* * .: :*. *..: *. * .:: :. * ..** . .: * . :: :*: :* .* :***:**::***** .. : *..: ***.*: :.* *: **: . . .. * . *. ** *: .*:: .: : *:** * ****:**:**:**::.. . *.:* : .: ** ::* ::*: *: :****:* :**::*. *::: *. . . :. *.. :*:*::*:*:**: * :. **:.:* **.**:. ***: ** . :::** *::* .**::: :****:::*.: :*:* * : : . .... * : : : * * ::.: . *.: : : . . .: .. : : : ** * ..:.. . :: . . .: . . : *.... : : : *. * :..* * ::*:: : *: : * : : . .** **. ***.**: ::*:*:** ***** * . :**:** :* *: :* **::* .* *.:.: * ::**: :.*.* : : * .:* *** * :*:* : : * : * :* .:* :*.:*:*:: :::: **:: * :**.::*: *:: *:* :*. :** *. ::****:*:*. . **..* : : *::.:::**:*: * *. ***:*:. ** *: .* * : ::*:.::*: :*:* :: :* ** * ::* . .:* :* *:.* * .: .. ::** .:.**:*** ::**::* . :* *.. .*: : *** ..*: : : : : *:: .: :::. : : .*. ::.: * * *: * ***.*:**.*:. *.: * *::.*:.* ..: .*. : *:***::*.. : *::: *: . .:**:::**:.** .**. :*: :: . . . . . . * **.:* :**:****: . .*. *. .* . * : : : : . :. * . :.:: * :. ... ** ****:..**: .*:**. ***::..**:***:*:* ::******:**:*:. ***** *** * **..** **:.****::* ** **:*** *:* * *******. :**::**:*******.::: * ***************.*****.*:** * ** :::**::* :* : : :**:**:**** : ::*:* *.:*: **.*****: :. :****.***** *::: ..::* ******::::.* * . ", "identical_positions": 535, "similar_positions": 582, "identity": "24.47%" }, { "cls_id": "homologset.agr.HGNC:16208", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P59383-1", "uniprot_id": "LRRN4_MOUSE", "id": "P59383-1", "name": "Leucine-rich repeat neuronal protein 4", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MRWTLMLQLLQLLLQLLM-------------------------------AQSQSLERISQDRIPLFRLTQQGDWDSLDRHPT----------------DSLCVG-----------------------------------------------LPAAGVTTLNLAN---RSLESLPSCLPRTLRSLDGSHNLLRALS------------------------------------------------EPVLGRLPELRVLTLHHNRISVLH---WGRDTLAELRELDLSHNLLTELPPCAGPSGSSLRSLALAGNPLRALLPRTFA------------------------CFPALRLLNLSCSELG-------------------HIAQEAFAGVDGGPLAALELLDLSGTSLERVESGWIRNLPKLKSLFLR-----------------------------------------------KMPRLKTLEGDIFKMTPNLRQLDCGDSPALTSVHTEIFQDTPNLQVLQFQNCNLSSFGPW--NSSQVLSVSLFGN-------------------------------PLICSCELAWLLVDVNKTVLHRAADTMCEPALGSTGPFSGPLSLSHLSNVCRSDQSTTLLPSNPGRFDHSVFAPR-------IQGPSIEQSTALSAQPGGSQQNITKVPSLTMTSPTQGSWMYKDASEET---------AQS-TNSELVYSPSRALPGAASSG-----AEQTATHILEPNISSASTPLVS-----------KYLEPLPTSPN-PRSLPQTKQRTQATPRALHT---------------------DPPQDEIPVL----------LLDDDSEEEE-TRDQVAAPPQDVSCEYHPCKHLQTPCAELQRRFRCRCPGLSGEDTTPDP-----------------------------------PTLQGVSEVTDTSVLVHWCAPNSVVLWYQIHYVAEGRSGN-----------------QSVV-DIYATARQHPLYKLTPGTTYHVCVLAANRAGLSQSQTSGWRRSCATFTTKPSSVVIFWGLCTASGLLLVSTLVLS-----------------------VCLWRQRWKPHRQFYDTHLVAFKN---------------------------------------------PARAEEVTQWE-----------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LTX4-1", "uniprot_id": "F1LTX4_RAT", "id": "F1LTX4-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MWWTLMLQLLQLLLQLQM-------------------------------VQSHSLEGLSQHQIPLFRLTQLGVWDSHDRRPN----------------DSSCEG-----------------------------------------------LPAAGATTLNLAN---RSLERLPSCLPRTLRILDGSHNLLHALS------------------------------------------------EPVLRRLPELSVLTLHHNRISVLH---WDGSTPTGLHELDLSHNLLAELPPCSGLSRSSLSLLSLAGNPLQALQPRTFA------------------------CFPELQFLNLSCSKLG-------------------HIAQEAFAGVDGGPLEALELLDLSGTNLERVESEWIRNLPKLKSLYLR-----------------------------------------------KMPRLKTLEGDIFKMTPNLRLLDCQESPALTSVHTEIFQDTPNLQVLQLQNCNLSSFGPWTVNSSQVLLVSLFGN-------------------------------PLICSCELAWLLLDASKTVLHRAADTTCEPALGSKGPFSGPLPLSHLSNVCRSDQSTTLLASNPPHDHHSVSAPW-------TQEPSIGQSRALSAQPEGSQQNITKVPSLTMAPPTQGSRTYRDTSEET---------AQSTTNSEIVYSPSRALPGTASSG-----AEQTDTYILEPSISSASTPLVS-----------KYLEPSPTSPN-PRSISQINQRTQANPKAFHT---------------------DPPQDEIPVL----------LLDDDSEEET-TQDQVAAPRQDVSCDYHPCRHLQTPCAELQKRLRCRCPGLSGQDTIPDP-----------------------------------PKLQGVSEMTDTSVLIHWCAPNSVVLWYQIHYLAEGGSGN-----------------RSVT-DIYATARQHPLYKLSPGTTYHVCVLAANRAGLSQPQTSGWGRSCATFTTKPSSVVIFWGLCTASGLLLVSTLVLS-----------------------VCLWRQRWKPHRQFHDTHLVAFKN---------------------------------------------PARSEEVTQW------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WUT4-1", "uniprot_id": "LRRN4_HUMAN", "id": "Q8WUT4-1", "name": "Leucine-rich repeat neuronal protein 4", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MRQTLPLLLLTVLR--------------------------------------PSWADPPQEKVPLFRVTQQGPWGSSGSNAT----------------DSPCEG-----------------------------------------------LPAADATALTLAN---RNLERLPGCLPRTLRSLDASHNLLRALS------------------------------------------------TSELGHLEQLQVLTLRHNRIAALR---WGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFA------------------------CFPALQLLNLSCTALGRG--------------AQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLERVESGWIRDLPKLTSLYLR-----------------------------------------------KMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGN-------------------------------PLTCSCDLSWLLTDAKRTVLSRAADTMCAPAAGSSGPFSASLSLSQLPGVCQSDQSTTLGASHPPCFNRSTYA----------QGTTVAPSAAPATRPAGDQQSVSKAP--NVGSRTIAAWPHSDAREGT---------APSTTNSVAGHSNSSVFPRAASTTRTQHRGEHAPELVLEPDISAASTPLAS-----------KLLGPFPTSWDRSISSPQPGQRTHATPQAPNP---------------------SLSEGEIPVL----------LLDDYSEEEEGRKEEVGTPHQDVPCDYHPCKHLQTPCAELQRRWRCRCPGLSGEDTIPDP-----------------------------------PRLQGVTETTDTSALVHWCAPNSVVHGYQIRYSAEGWAGN-----------------QSVVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLSQPRSSGWRSPCAAFTTKPSFALLLSGLCAASGLLLASTVVLS-----------------------ACLCRRGQTLGLQRCDTHLVAYKN---------------------------------------------PAFDDYPLGLQTVS--------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VAD1-1", "uniprot_id": "Q9VAD1_DROME", "id": "Q9VAD1-1", "name": "LRRCT domain-containing protein", "aln": "MEAWKQLPNGGRFLLLLLACIAHLGHPILAWRPCPELSPALRLPCRCNVVPFAATGQLGAVAMDCDRVVFHGDAPQLPYGAPIVAYTQRHSGQQVLPAQTFGQLKLTIEELDLSYNLIRRIPEKAFDGLKDSLNELRLANNLLGDNLNPIFSTAELHVLKNLRLLDLSGNKIKLIEEGLLKGCMDLKEFYIDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQLEIIDLRHNVIRSIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKHLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVLPELRSLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQISGDLLAGLQDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDISDN-QLSYLFPSSFRIHPRLREIRAANNKFSFFPAELISTLQYLEHIDLSHNQLKTIEELDFARLPRLRVLLVANNQLDMVSEMAFHNSTQLQILDLAHNNLDRIGERTFEGLVRLEQLNLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSSVDLSHNKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGTGIENLELLETPFLQFLNLSHNKLKNVKPEVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNFGKLEMLRSLRLSHLPQCTRIEKNAFKQLPNLVSLEAYDLPLLGYLDLQGILELLPGLEVLDIEVKDSSIGSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVPQFLNALEDRRASLQLQGLASNPIVCDCNARALRRWLPSSGMPDVTCASPAYLLNRKLIEVGDDELTCDARRMTSSTSRPTASVPHLLKTSSQLVTRSSSTTEEPLIIWSLEPTQPPSLKKMKTKAPLMKAQSPIISNDDTLIIGIVGGVVAFIAILIIIICIIRLRMSNAEYQQNATMIGIPAGMQMGAHNAAYNYKNGAGAALYAVPPYHATLPHKAASIHQSSQNLSQRQQQQQQQQQVAAAAAAYSTMSRMSYFSGAGGGNGDGAESLTHQHPHQHQPYIIYSDDKAYR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * * :* * * . : :* .* * : . .. ** . .... . *.*:. :.*: : *:*. ** *:* : ::: . * :* :* * * :**::.* . : *.** * : *** : *** * *:**.* .: . :** :* *: *:** . * .::* ** *:::**** :.::.. : .* .*. ::*. : :*.:::*: *: ..:. ** :. *: : . *: *.*: : * ::* * . .: * * :.: : . : * :. * * .: **.*.. . . : . .: * .:: * . *.:. : : : . .: :. : . . . * : : : . * * :. :*. * * : * . .* : .* . :: . . ::*:* ** . . : ::. . * . .: : * .*: .**..:* : * : .. * :* :: *.*.:* : : . ... . *. : : :. .* * * . : * :* . :: :*: : : : : *: ..: ::* *: * . :: ::. . : ", "identical_positions": 120, "similar_positions": 223, "identity": "8.61%" }, { "cls_id": "homologset.agr.HGNC:16209", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CSU0-1", "uniprot_id": "RPR1B_MOUSE", "id": "Q9CSU0-1", "name": "Regulation of nuclear pre-mRNA domain-containing protein 1B", "aln": "MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRK--AKSNRKLTFLYLANDVIQNSK-RKGPEFTREFESVLVDAFSHVAREAD-EGCKKPLERLLNIWQERSVYGGEFIQQLKLSME----------------DSKSP-----------PPKAA-------EEKKS-LKRTFQQIQ---------EEE---DDDYPGSYSPQDP---SAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKIT-----DKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQN------------QKEVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD---------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NQG5-1", "uniprot_id": "RPR1B_HUMAN", "id": "Q9NQG5-1", "name": "Regulation of nuclear pre-mRNA domain-containing protein 1B", "aln": "MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRK--AKSNRKLTFLYLANDVIQNSK-RKGPEFTREFESVLVDAFSHVAREAD-EGCKKPLERLLNIWQERSVYGGEFIQQLKLSME----------------DSKSP-----------PPKAT-------EEKKS-LKRTFQQIQ---------EEE---DDDYPGSYSPQDP---SAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKIT-----DKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQN------------QKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B9C1-1", "uniprot_id": "A0A8M2B9C1_DANRE", "id": "A0A8M2B9C1-1", "name": "", "aln": "MSSFSESALEKKLSELSNSQQSVQTLSLWIIHHRKHAALIVRVWHRELKK--AKSSRKLTFLYLANDVIQNSK-KKGPEFAKDFEGVLIDACSHVARDGD-DGCKKQMDRLLTIWQERNLYRPDFIQQLKLTID----------------DSESP-----------KHKTAG--QRNADDRKN-LKRSYQKVQ---------EEEEEEDDDYRGHYSPRETD--AAAPQLTEDLVKALQDLENAASGDAAVRQKIASLPQEVQDVSLLEKITA----DKQAADKLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLTEYIQS------------QKDALNEREKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD---------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W039-1", "uniprot_id": "Q9W039_DROME", "id": "Q9W039-1", "name": "CID domain-containing protein", "aln": "MSAFTDSALLKKLAELNSSQQSIQTLSLWLIHHRKHSAAIVRTWQRELEN--VPEPKKLTFMYLANDVIQNSK-KKGPEYGKEYSLVLGKVFAHIGEKCNSDKLLGSLGRILNIWLERGVYDPKTIADWRSRLHKEAPGSSSSSNGKTNGDSEKPEKEKDHGGSGKPEKSERREKRKHEDRHSKSKRSRHHVQGSSANSAPPTEEVVSVEPENGHTPPYLP---LGEPPEPEELIRALTSIENSASSDAVVRERIAKLPQEISEISCISKLE-----DKDKAKELAIQVNEAVDLLNDYNARLAAEMEERSKLATMLRDFQAE------------QKELLSQAEQRLDEHKKKLAKMLGLQKEIHDHLSNLPDLTRLPDVTGGLAPLPSAGDLFNALH--------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q05543-1", "uniprot_id": "RT103_YEAST", "id": "Q05543-1", "name": "Regulator of Ty1 transposition protein 103", "aln": "-MPFSSEQFTTKLNTLEDSQESISSASKWLLLQYRDAPKVAEMWKEYMLRPSVNTRRKLLGLYLMNHVVQQAKGQKIIQFQDSFGKVAAEVLGRINQEFP-RDLKKKLSRVVNILKERNIFSKQVVNDIERSLK----------------TESSPVEALVLPQKLKDFAKDYEKLVKMHHNVCAMKMRFDKSS---------DELDPSSSVYEENFKTISKIGNMAKDIINESILKRESGIHKLQSTLDDEKRHLDEEQNMLSEIEFVLSAKDPSRLNKNVDEDNIIPTYEVGDGDDDDDDGDNDDDDDDDDDDKNYDDRSNDSNYGVTNISTTDKKNEVVEKTDSEHKNSTHNPSDNQFGMKRTHDMIGHDDANDIPEKKVHLDSKTSEDGTFNSEDGHYELDIEGHVGAQTDEGVENSGGVSSSIQDLLSKLAN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .*:.. : .** *..**:*:.: * *:: : :.: :. *:. : . . :** :** *.*:*::* :* :: .: * .. .:: .. : *::.* **.:: . : : . :. ...* ... * .: . * . . . *.::: .:.: * :.:: . : :.::. : . :*: . . *. : : : :: . : . :*: : : . .: . : . . : .: . * . :*: . * . .* .. *.: ", "identical_positions": 37, "similar_positions": 127, "identity": "8.49%" }, { "cls_id": "homologset.agr.HGNC:1621", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q61390-1", "uniprot_id": "TCPW_MOUSE", "id": "Q61390-1", "name": "Probable T-complex protein 1 subunit zeta-2", "aln": "MAAIKIANPGAEVTRSQAALAVNICAARGLQDVLRPTLGPKGALKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASIIAKVAAAQDHVTGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFDVAKTKALEVLDEIKVQKEMK---REILLDVARTSLQTKVHAELADILTEAVVDSVLAIRRPG--VPIDLFMVEIVEMRHKSETDTQLIRGLVLDHGARHPRMRKQVRDAYILTCNVSLEYEKTEVSSGFFYKTVEEKEKLVKAERKFIEDRVQKIIDLKQKVCAE-SNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLERLTLACGGLAVNSFEGLSEECLGHAGLVFEYALGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQIKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNY---KHRVQGRVRLGIQAFADALLIIPKVLAQNSGYDLQETLIKIQTKHAESKE-----LLGIDLNTGEPMAAAEAGIWDNYCVKKHLLHSCTVIATNILLVDEIMRAGMSSLRD---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92526-1", "uniprot_id": "TCPW_HUMAN", "id": "Q92526-1", "name": "Probable T-complex protein 1 subunit zeta-2", "aln": "MAAIKAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEEVKVTKEMK---RKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPG--YPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQ-SNKGFVVINQKGIDPFSLDSLAKHGIVALRRAKRRNMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVNPCSVTLLVKGPNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTY---KNSIKGRARLGVQAFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQ-----LVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLK----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VXQ5-1", "uniprot_id": "Q9VXQ5_DROME", "id": "Q9VXQ5-1", "name": "", "aln": "MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPVEIN---KKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVRAEREFIDQRVKKVIELKRSVCDG-TDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAF---KDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPE-----LVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVMRAGMTSLKG---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39079-1", "uniprot_id": "TCPZ_YEAST", "id": "P39079-1", "name": "T-complex protein 1 subunit zeta", "aln": "-MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQ-ADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. *. ** * ** :*: :*.***.*:...*****::****.***:**:****:*** ***** *** :**:.::***. ******: * ::****:**. ::.**:****:::**: *: ::::.*::.*: :: *::**.:** ***.. *:::** .::**:: . :**.***:::*:* .** :::***:***.*** * .::.:*::* ********:**.*****.:.:::: :. :**:*:: :::*:*:** .** .:* **:********.**: :**..*:*********:*** *. ** * **.:.* : **.:*:*:: .:**:*:*:: : :* * *:*:**..:::: * ***:******: *.: * ::*****. : . * * :*: : .::***:***:***.*. *:*:* :.: : : : : :*:** *:. .. *::*.* * :: : ..: **:*:** **::*** ::*: ", "identical_positions": 229, "similar_positions": 191, "identity": "41.79%" }, { "cls_id": "homologset.agr.HGNC:16211", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZCM8-1", "uniprot_id": "D3ZCM8_RAT", "id": "D3ZCM8-1", "name": "", "aln": "MWKRTDPQAKIKAGDRPQTCHSLALGSATESALPHPLELSDFQSFSVFEDISHHIKEGGAQLVKKVNAIFQLDITKDGKTILQWTIDLKNGSGDMYLGSAR-LPADTIFIIPDTVFTELVVGKMNPQKAFLAGKFKVRGKVLLSQKLERIFREWAKF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DAH1-1", "uniprot_id": "SCP2D_MOUSE", "id": "Q9DAH1-1", "name": "SCP2 sterol-binding domain-containing protein 1", "aln": "MWKRPDPQAKIKAGDRPQTCQSLALGSATESALPQALKLSDFQNFSVFEDISQHIKEVGAQLVKKVNAIFQLDITKDGKTILQWTIDLKNGAGDMYLGSAR-LPADTVFIIPDSVFTELVVGKINPQKAFLAGKFKVRGKVLLSQKLERIFREWAKI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJQ7-1", "uniprot_id": "SCP2D_HUMAN", "id": "Q9UJQ7-1", "name": "SCP2 sterol-binding domain-containing protein 1", "aln": "MWKRSDHQPKIKAEDGPLVGQFEVLGSVPEPAMPHPLELSEFESFPVFQDIRLHIREVGAQLVKKVNAVFQLDITKNGKTILRWTIDLKNGSGDMYPGPAR-LPADTVFTIPESVFMELVLGKMNPQKAFLAGKFKVSGKVLLSWKLERVFKDWAKF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VY92-1", "uniprot_id": "Q9VY92_DROME", "id": "Q9VY92-1", "name": "SCP2 domain-containing protein", "aln": "---------------------------------------MSLQSDAVFQKIIDGLKE-NEAKAKAVNGVFLYKITKDGKVAKEWTLDCKN--AKAYEGPAQGIKVDTTLTVADEDMVDIALGKLNPQAAFMKGKLKIAGNIMLTQKLAPLLKTDAKL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .::. .**:.* ::* . .* **.:* .***:**. .**:* ** .. * *.*: : .** : :.: : ::.:**:*** **: **:*: *:::*: ** ::: **:", "identical_positions": 39, "similar_positions": 45, "identity": "24.84%" }, { "cls_id": "homologset.agr.HGNC:16212", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JW48-1", "uniprot_id": "A0A0G2JW48_RAT", "id": "A0A0G2JW48-1", "name": "", "aln": "MGHLGTDRPTLISCPLSAYWPLPAAGVSGSMVFCLENKMPHRLLGSAMVHFHASEVQQLLHNKFVVILGDSIQRAVYKDLVLLLQKDTLLTASQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSGSGHHLVRFYFLTRVYSEYLEDVLEELSYGPAPDLVIINSCLWDLSRYGRCSMESYRENLERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSATLAGNHCFDVLDLHFHFRHAVRHRHRDGVHWDQHAHRHLSHLLLTHVADAWGVELPKHDRLPDPWIEDWPEMDHSYQGSHKQPPDFREKPALPLLPPFHLPPPMSFPYPL-QPSPPPLFPPLPQDTPFFQGQPFPPYEFK-YNAMEDFSMP---GCGPGMNFVPGPLPPSVSGPVSHGQHRGPVVHRGKPRCVLNNPYHVPRIGGPCRHRLRHSDRLIHTYKQDRRGYAHSGTWPG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P1Z5-1", "uniprot_id": "PED1A_MOUSE", "id": "Q6P1Z5-1", "name": "PC-esterase domain-containing protein 1A", "aln": "------------------------------MVFCLENEMPHRLLGSAMVHFHASEVQQLLHNKFVVILGDSIQRAVYKDLVLLLQKDTLLTASQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSGSGHHLVRFYFLTRVYSEYLEDILEELSYGPAPDLVIINSCLWDLSRYGRCSMESYRENLERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSATLAGKHCFDVLDLHFHFRHAVRHRHRDGVHWDQHAHRHLSHLLLAHVADAWGVELPKHDRLPDPWIEDWSEMDHSFQGSHKQPPDFREKLALPLLPPFHLPPPMSFPYPL-EPSPPPLFPPLPQDTPFFQGQPFPPYEFK-YNAMEDFSMP---GCGPGMNFVPGPLPPSVSGPVSHGQHRGPVVHRGKPRCVLNNPYHVPRIGGPCRHRLRHSDRLIHTYKQDRRGHAHSGTWPG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1Q7-1", "uniprot_id": "PED1A_HUMAN", "id": "Q9H1Q7-1", "name": "PC-esterase domain-containing protein 1A", "aln": "------------------------------MVFCLSSEEPRRPLRSDMVHFQASEVQQLLHNKFVVILGDSIQRAVYKDLVLLLQKDSLLTAAQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSGSGHHLVRFYFLTRVYSEYLEDVLEELTYGPAPDLVIINSCLWDLSRYGRCSMESYRENLERVFVRMDQVLPDSCLLVWNMAMPLGERITGGFLLPELQPLAGSLRRDVVEGNFYSATLAGDHCFDVLDLHFHFRHAVQHRHRDGVHWDQHAHRHLSHLLLTHVADAWGVELPKRGYPPDPWIEDWAEMNHPFQGSHRQTPDFGEHLALLPPPPSSLPPPMPFPYPLPQPSPPPLFPPLPQDTPFFPGQPFPPHEFFNYNPVEDFSMPPHLGCGPGVNFVPGPLPPPIPGPNPHGQHWGPVVHRGMPRYVPNSPYHVRRMGGPCRQRLRHSERLIHTYKLDRRPPAHSGTWPG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *****..: *:* * * ****:***********************************:****:************************************************************:****:****************************************************:*******:************* ***:**************.****************:**********************:************:. ********.**:*.:****:*.*** *: ** ** *****.***** :***************** ******:** **.:****** *****:*********.:.** .**** ******* ** * *.**** *:*****:*****:******* *** ********", "identical_positions": 386, "similar_positions": 38, "identity": "79.75%" }, { "cls_id": "homologset.agr.HGNC:16213", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZXL1-1", "uniprot_id": "A0A8I5ZXL1_RAT", "id": "A0A8I5ZXL1-1", "name": "", "aln": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADRQDAAASNVSGSQLQNNLNLESDSTSETSFPLSKEAP---EEHQVVHQPFPRQRFPQETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPD-SEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSG------DQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2ATD1-1", "uniprot_id": "ISM1_MOUSE", "id": "A2ATD1-1", "name": "Isthmin-1", "aln": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAG-------NNNLNLESDSTSETSFPLSKEAP---EEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPD-SEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSG------DQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B1AKI9-1", "uniprot_id": "ISM1_HUMAN", "id": "B1AKI9-1", "name": "Isthmin-1", "aln": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPD-SEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSG------DQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5EGE1-1", "uniprot_id": "ISM1_DANRE", "id": "Q5EGE1-1", "name": "Isthmin-1", "aln": "MVRLAAELLLLLGLLLLTLHITVLRSSPLQHGNDTVSLEQDSRVAENNVNADS-SSSVQLGPGDRQTR---VAHIPASQPWAQS---PGTGG-SLQRDGPGAFLLDLQNFPDLSKADINGQNPNIQVTIEVVDSLEGSEPEKGMRKENKPGWAAP--NWRNWWQRSSSSSSSSVSTPKGPEEQDYPYESNTEDSNFLKPLGDWERRVKSEAGAGSRTQTEYDYIDGEGDWSAWSPCSVSCGNGNQKRTRSCGYACTATESRTCDMPSCPGIEDAFKTAATEVSLLAGTEEFNATELFGVDTDSCERWMNCKSEFLKKYMSKVATDLPSCPCFYPTEVAYSTADVHDANTKRNFRWKDASGPKEKLEIYKPTARYCIRSMLTLESTTLAAQHCCYDDSMKLITRGKGAGTPNLISTEFSADLHYKVDILPWIICKGDWSRYNHARPPNNGQKCAENPQDEDYYKQFEEAREF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*************************.* . *:.: :**:* * ::* . .::: * . **:.: ** ***** * :***** *************************. : **.:*. : ****.*: * :** ***** * : :. . :** *:*.::*****. .*:: . .. :: *.*** ******* ** ***:**************** ******** *.******:*:***********:******:** ** *******.********** ** .******* ***********:.* .:::****************************:*************.*.*:********************:******:**************.**********:*.*.**** ***:****:", "identical_positions": 313, "similar_positions": 73, "identity": "66.45%" }, { "cls_id": "homologset.agr.HGNC:16216", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A8H6-1", "uniprot_id": "D4A8H6_RAT", "id": "D4A8H6-1", "name": "", "aln": "MAQKPLSTTAAERMNLVAQDEIWKYRLKAESEARQNWPSKWGYLTTSMKELLEGDEEPHTPKPKVELPSHFRVHPVSPLDKYIKILPSPPVPKTTQGFIGWRSGLP--LYCLEKYTEIRSCKGAYARDLRWPKQGVH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DA42-1", "uniprot_id": "CMIP1_MOUSE", "id": "Q9DA42-1", "name": "Ciliary microtubule inner protein 1", "aln": "MAQKPLSTTAAERMNLVAQDEIWKYRLRAESEARQNWPAKWGYLTTSMKELLEGEEEPQTPKPKPELPSHFYVRPVSPMDKHIKILPSPPVPKTTQGFIGWRSGKPA-LYCLEKYSEVCSCKGAYARELCWPEQGVH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1P6-1", "uniprot_id": "CMIP1_HUMAN", "id": "Q9H1P6-1", "name": "Ciliary microtubule inner protein 1", "aln": "MAQKPLSTAAAERMNLVGQDEIWKYRLKAESEARQNWPQNWGFLTTPFEELIKCEEDLPTPKPKIELPERFRIRPVTPVEKYIKVFPSPPVPQTTQGFIGWRSAVPGLNKCLELDDAIRSCKGAFARELCWPKQGVH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "********:********.*********:********** :**:***.::**:: :*: ***** ***.:* ::**:*::*:**::******:**********. * *** : *****:**:* **:****", "identical_positions": 92, "similar_positions": 28, "identity": "67.15%" }, { "cls_id": "homologset.agr.HGNC:16217", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GJA8-1", "uniprot_id": "A0A8I6GJA8_RAT", "id": "A0A8I6GJA8-1", "name": "", "aln": "MTRGMTRAMRRAVDMAR-----------------AGARPPKKHGDD----PKAG-----ARPAQPSSRARARIKGHTGDPLASTASPDLTPDVYVLRVRLEETGELFRVANCRSDMTVRELKEELDLMVGIPFNLQRLHFLDQGILMDDATLKFYDVIPGAIISLCIWHYDGWTELVLAAVEGDPSKMSCLGISEDTFYRTANSQHFKGEQWRQWTAQRAFVALYVSAHRGHVDAVQYLLELGANCLAKSPLGRTPLHVAAAMGRTECIQPLLEHGASIHDRDLKSETPVTIARRLKRGNFERKMFILYWMIKSGTRDP-DLVSRDASEKHSPGVMARKTSVLIS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AMD2-1", "uniprot_id": "A2AMD2_MOUSE", "id": "A2AMD2-1", "name": "", "aln": "MTRGMTRAMRRAADVAG-----------------AGARPPKRQGDD----PKAG-----ARHTQPSSRARAQVRGHTGDPLASTVSPDLTPDVYVLRVKLEETGELFRVANCRNDMTVRELKEELDLMVGIPFNLQRLHFLDRGILMDDATLKFYDVIPGALISLCIWHYDGWTELVLAAVEGDPSKMSCLGISEDTFYRTANSQHFKGEQWRQWTAQRAFVALYISAHRGHVDAVQYLLGLGANCLAKSPLGRTPLHVVAAMGRTDCVQPLLEHGASIHDRDLKSDTPITIARRLKRGHLEHKMFLLYWMVKSGSRDP-DLVGRKALEKSSPGMATRRSTILIS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZ19-1", "uniprot_id": "ANR60_HUMAN", "id": "Q9BZ19-1", "name": "Ankyrin repeat domain-containing protein 60", "aln": "MTRGRAWGMRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLACARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLMVGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHRLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** : .****. * ** *. : * : *:.* * :** : **.: : . ** *::. ***:***:****:******:*******.************************::**.*:****:****:**:**.:*******:*****************:****::**:*******:**:**:*::**:********:::****.******* **.**::**********.*****::*: **:********* *.:**::**:**:: *::*.:*: : *** ** *** :.* :: ..*. :.: :: ", "identical_positions": 199, "similar_positions": 79, "identity": "57.68%" }, { "cls_id": "homologset.agr.HGNC:16219", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DD18-1", "uniprot_id": "DTD1_MOUSE", "id": "Q9DD18-1", "name": "D-aminoacyl-tRNA deacylase 1", "aln": "MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISMEDSQKELEHMVRKILNLRVFEDESGKHWSKSVMDKEYEVLCVSQFTLQCVLK-GNKPDFHLAMPTEQAESFYNSFLEQLRKSYRPELIRDGKFGAYMQVHIQNDGPVTIELESPAPGAASSDPKQLSKLEKQQQRKEKTRAKGPSESSKERNAPR-KEDRSASSGAEGDVSSEREP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TEA8-1", "uniprot_id": "DTD1_HUMAN", "id": "Q8TEA8-1", "name": "D-aminoacyl-tRNA deacylase 1", "aln": "MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLK-GNKPDFHLAMPTEQAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQLSKLEKQQQRKEKTRAKGPSESSKERNTPR-KEDRSASSGAEGDVSSEREP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6A4Q0-1", "uniprot_id": "A0A8I6A4Q0_RAT", "id": "A0A8I6A4Q0-1", "name": "D-aminoacyl-tRNA deacylase", "aln": "------MLLAQNVTLEIYQISAIGRGICVLLGISMEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKEYEVLCVSQFTLQCVLK-GNKPDLHLAMPTEQAESFYNSFLEQLRKSYRPELIRDGKFGAYMQVHIQNDGPVTIELESPAPGAASSDPKQVTPTNNILKLTNKK--------STGKCKP----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F1QGC8-1", "uniprot_id": "DTD1_DANRE", "id": "F1QGC8-1", "name": "D-aminoacyl-tRNA deacylase 1", "aln": "MKAIIQRVTRASVTVGEEQISSIGRGLCVLLGISVEDTQKDVDYMVRKILNLRVFEDENGRAWSRSVMDGELEVLCVSQFTLQCLLK-GNKPDYHAAMPAELAQPFYNNMLEQLRETYKPELIKDGQFGAKMQVLIQNDGPVTIQLESPP---APTDPKLLSKQEKQQQRKEKTRSKGPSDSSREKAAQRSKVDPSASSGAEGDVSSEREP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VGP0-1", "uniprot_id": "DTD_DROME", "id": "Q9VGP0-1", "name": "D-aminoacyl-tRNA deacylase", "aln": "MRAVIQRVKAAKVTVLDELVSSIGPGLCVLVGIKASDTAKDVEYLVRKILALRLFEEE-GKRWQKSVKDLNLELLCVSQFTLYHRLK-GNKPDFLAAMKGEEAQELYNQFLDRLGQSYDSTKIKDGKFGAYMQVHIENDGPVTINLESPE-------------QKDTDREVDK--------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07648-1", "uniprot_id": "DTD_YEAST", "id": "Q07648-1", "name": "D-aminoacyl-tRNA deacylase", "aln": "MKIVLQKVSQASVVVDSKVISSIKHGYMLLVGISIDDSMAEIDKLSKKVLSLRIFEDESRNLWKKNIKEANGEILSVSQFTLMAKTKKGTKPDFHLAQKGHIAKELYEEFLKLLRSDLGEEKVKDGEFGAMMSCSLTNEGPVTIILDSDQ-------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .*.: :*:* * :*:**. .*: ::: : :*:* **:**:* . *.:.: : : *:*.****** * *.*** * . *: :*:.:*. * . ::**:*** *. : *:***** *:* ", "identical_positions": 48, "similar_positions": 44, "identity": "22.75%" }, { "cls_id": "homologset.agr.HGNC:1622", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AR12-1", "uniprot_id": "A0A8I6AR12_RAT", "id": "A0A8I6AR12-1", "name": "T-complex protein 1 subunit eta", "aln": "----MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQRKMLEKCAMTALSSKLISQQKVFFAKMVVDAVMMLD-ELLQLKMIGIKKVQGGALEESRLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALIPDVLGRCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNEDIADNFQAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS-TVDAPAP-AAGRGRGQGRFH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P80313-1", "uniprot_id": "TCPH_MOUSE", "id": "P80313-1", "name": "T-complex protein 1 subunit eta", "aln": "----MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQRKMLEKCAMTALSSKLISQQKVFFAKMVVDAVMMLD-ELLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALVPDVLGHCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNENIADNFQAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS-TVDPPAP-SAGRGRGQARFH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99832-1", "uniprot_id": "TCPH_HUMAN", "id": "Q99832-1", "name": "T-complex protein 1 subunit eta", "aln": "----MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLD-DLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS-TVDAPT--AAGRGRGRGRPH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VHL2-1", "uniprot_id": "Q9VHL2_DROME", "id": "Q9VHL2-1", "name": "T-complex protein 1 subunit eta", "aln": "-----MQPQIVLLKEGTDSSQGKPQLVSNINACQSIVDAVRTTLGPRGMDKLIVDAHGKATISNDGATIMKLLEIIHPAAKTLVDIAKSQDAEVGDGTTSVVLLAGEFLKQVKPFVEEGVHPRVIIKAIRKALQLCMEKINEMAVQIVEQSKDQQRALLEKCAATAMSSKLIHQQKDFFSRIVVDAVLSLD-ELLPLNMIGIKKVTGGSLEESQLVSGVAFKKTFSYAGFEMAPKSYDNCKIALLNIELELKAERDNAEIRVDNVKEYQKVVDAEWQILYNKLAKIHESGANVVLSKLPIGDVATQYFADRDIFCAGRVPEEDLKRTMKACGGAVMTTANDIKPNVLGLCEHFEERQVGGERFNLFQGCPNAKTSTLILRGGAEQFLEETERSLHDAIMIVRRTIKHDSVVAGGGAIEMELSKLLRDYSRTIAGKEQLLIAAIAKGLEIIPRQLCDNAGFDATNILNKLRQKHAQGGQWYGVDINKEDISDNYEQCVWEPSIIKINALTAAAEAACMILSVDETIKSPKA-GEPPMAGGGMGMGRGMGRPM", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P42943-1", "uniprot_id": "TCPH_YEAST", "id": "P42943-1", "name": "T-complex protein 1 subunit eta", "aln": "MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSE-KSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :::******:*** *::***.** : :*::.**** * * *** .. *:*********:***:::**********:::************.:**.*::*:.**::***: .::*::. *.* .*.::**:*:** : . * . * :**:** **:***** :: ** :: ****: ** : * ::*****: **::*:* :: ************** **.:.* ** **:*******:****:**. *::** :*****:::::** ::..:**:::********:***:****::******. :*::*.: * **:: ::.. : .: ** * *** *:*.**:*:* ***:***.*::*******.: *.***********:*::::. :****** ***:** *****:**.**:*::* * **.**:******:****** :****** *::* **** ::.*:*.**: ****::::****.:*:**: :*:******.. : . * *** . ", "identical_positions": 297, "similar_positions": 159, "identity": "53.9%" }, { "cls_id": "homologset.agr.HGNC:16223", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BG94-1", "uniprot_id": "COMD7_MOUSE", "id": "Q8BG94-1", "name": "COMM domain-containing protein 7", "aln": "-------------------------------------------------------------------MGRLHCTQDPVPEAVRGDMQQLNQLGAQQFSDLTEVLFHFLTEPKEVERFLAQLSEFATSNQISLGPLKSIMKSLLLVPNGALKKGLTAEQVRTDLQTLGLSEEKATYFSEKWKQNASTLAQWAMGQTLMVNQLIDMEWRFGVTSGSSELEKVGSIFLQLKLVVKKGKQTENLYME---------------------LTLP----QFYSFLHEMERVRAS-MECLS----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86VX2-1", "uniprot_id": "COMD7_HUMAN", "id": "Q86VX2-1", "name": "COMM domain-containing protein 7", "aln": "-------------------------------------------------------------------MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIE---------------------LTLP----QFYSFLHEMERVRTS-MECFC----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0LV51-1", "uniprot_id": "A0ABK0LV51_RAT", "id": "A0ABK0LV51-1", "name": "", "aln": "MLYIQGLPGRDLESYWDAQSGSWNPAAARALSRDRRLGVWRKCGCGSAARPGRRKRAPLPGCGAPGTMGRLHCTQDPVPEAVRGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGPLKSIMKSLLLVPNGALKKGLTAEQVRTDLLTLGLSEEKATYFSEKWKQNAPTLAQWAIGQTLMINQLIDMEWRFGVTSGSSELEKVGSIFLQLKLVVKKGKQTENLYIASCTRWRESERAWSASADPVSPMATPGSQLPWEARCKEFLKPRVSVLEESCPILM", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *******:******* *************** ***************************:******.*:**:*************.***:**::*: ********************.***:**:*****:********:***************************:****:*: :: * : : :*: : *.* :* . ", "identical_positions": 159, "similar_positions": 28, "identity": "53.54%" }, { "cls_id": "homologset.agr.HGNC:16225", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AGP4-1", "uniprot_id": "A0A8I6AGP4_RAT", "id": "A0A8I6AGP4-1", "name": "", "aln": "ETLHLLRGGCLGDCGNFAVLVDLHVLPQGSNKDSSWFSEQKKEEVCLLLKETIDSRVKEYVGIYKQHRPST--AEFSRSSPLSLKGYGFQITAYFIRRGIHLRCIQSSRNTELRIFPESFVVCVSQLAFGHDTWANQNEKSTQRALHGASDYFAQCAESS--PPPGIKLKRNTLKEIVRRAESKGTDVSKPQTS------RDLVGKSSDSVITVVPRRRD------------------------ASAILLSEPVGQAQDDIRAAKSHQELP----------------VQKLENVSQTQPGDTRSQQQLHPGEWLKTGLLSRSPVYNYESASPGPKQSPRAAKTQQKRR---------------------NCGSVEDSDHRRRVSLGNEGLVPEDSVVETSTAVRVLPALELSN-------PGLLLKQDLAKATAKEELHALENLSSRHLVTDNPGQARPTGSATVTERLAPV--------QSGPSKKRKKLQSSSRGCSGKKS---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D7Y9-1", "uniprot_id": "SLX4I_MOUSE", "id": "Q9D7Y9-1", "name": "Protein SLX4IP", "aln": "----MASKKFAVKCGNFAVLVDLHVLPQGSNRDSSWFSEQKKEEVCLLLKETIDSRVKEYVGIYKQRKPSS--AEFTRSSPLSLKGYGFQITAYFLKRGIHLHCIQNSQNTELRVFPERFVVCVSQLAFGHDIWANQNEKSTKKALHGVSDYFPECAESS--PSPGTKLKRNALKEIVRRTKSKGTDVSKPQPS------GDLVGRSSDSVITVVPWRRD------------------------ASAILLSESVGQAQDDIRAAKSHQELP----------------VQKLENVSQTQPGDTRSQQQLHPGEWLKTGLLSRSPAYNYESASPGPKQSLRAAKTQQKHR---------------------NCGSVEDCDHRRRVSLGNEGLVPEDADRERSTAVRVLPALELSD-------PGLLLKQDLAKAKAKEELHALENLSSRHLVTNNPGQAQQSDSAAITEQLATD--------QGGPSKKRKKLQSYNRGCSGKKN---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VYV7-1", "uniprot_id": "SLX4I_HUMAN", "id": "Q5VYV7-1", "name": "Protein SLX4IP", "aln": "----MASKKFAVKCGNFAVLVDLHILPQGSNKDTSWFSEQKKEEVCLLLKETIDSRVQEYLEVRKQHRPSN--AEFTRSNPLSLKGYGFQITAYFLKRGIRLRCIRSTQNAELCVFPDRFVVCVSQLAFSRDLLASQNEDLTERVLHGVSDYFAECAESS--LPPSAKLRRNALKEIVKRTETKSSVTSKSQTR------RDTVETSSDSVIAEIARRRNDG---------------------QASSSPPSESMGQAKDSIKAAESHWGLP----------------VQKLEKVNQTQPEDTSGQQKPHPGERLKTGLLSRSPVCSCESASPCPKQSPRVAKTQQKRR---------------------NCSSAEDFDHHGRVSLGSDRLVPREIIVEKSKAVRVLPASELSD-------PGLLLKQDLAKTTSKEELHVLESLSSRHLMKNNPGQAQQTGLATNTERLSTI--------QNSPTKKRKK---YERGH--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7T2B3-1", "uniprot_id": "SLX4I_DANRE", "id": "Q7T2B3-1", "name": "Protein SLX4IP", "aln": "----MEPSKFVVKCGNYAVLVDLHILALGDQDNANWFSPAHRKEVGSLIRDALEPRVRQFQEARYQKIQSKPRKDLTPTAPLCLEGGNVRLAVHFMKRHVNLRCIVRQHYRELRVFPERVVVCASPPENSALPNGNLNLDVSE---QSQSKYFSNSGETANPLQSSTATKRAVLQKIARKTKIQPPRSQDNQESKTGQFQADNAEKGSRSVLQRITRQANIQPQQCQDDQVYKSGQFQADKQEKGSGDVLQKITRQANIQPQQCQDDQESKSGQVQADKEENGSGDVLHKIAKQTNTQPPQSQDDQEFKSGQFPAGESEKGSRSVLQEIARQANIQSPHSQEDQEFKSGQFQVAEECVEACLPVPISVSSIKSLVDVKALSSSKLSNNKDVTESYLDTTGPRRRPRAPSSSGEDADHQKTKRLRLGQSAVSSDSNNPSSGIAAPDSVCSPQPEISQTNQSGLATSLRGLSVKPVSSGSSISSRPAAREERKGGEPRTSRLRRLKKS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .***:*******:*. *.: ::.*** :::** *::::::.**::: *: *. ::: : **.*:* ..:::.:*::* :.*:** : ** :**: .***.* . .. * . :: :. *.**.:..*:: .. :* .*::*.:::: : . .. * * . .* **: :. : : .*. .: **: . : .:.. ::*: : .:*** :: .:*: :.*: . * * * ** : : *: : . * * . .*..: *... . * .. . .: * * *. ..: ::: : .* : .*:. :. *: . *: .. *: :.:: * ", "identical_positions": 81, "similar_positions": 155, "identity": "16.01%" }, { "cls_id": "homologset.agr.HGNC:16226", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZWF9-1", "uniprot_id": "D3ZWF9_RAT", "id": "D3ZWF9-1", "name": "", "aln": "MTEPSLLPAAQMEGLALLP----LASPCPRIPRARISRQ---PGRWAHLGCSPGPSTG-PTNLPRYPLKPRPADCAYSRLSWAESLSMDGFWPGVERIQQRGE-RKKEDCGGSRSQLL-EGDAESQWLQDTG-LAGLVGGLGLDD----DHQGLLSTLTQTQVAAVCRRLDIYARSARRRQKAPVRDVRDIFGVFTSREAAPEN-----------GDSGMKWTEFNSEDSASPLRPA--GGPQEPAGMEEVFNMESAYSEQAAVLLQ---RTWSSPEGARAWGKGCLPRFRIPKGRLG---------VTRIGDLSSRDMKKILPLALIELTALYDILGLDLKRSKGRKWKGADSG-LFGVPLHSLLEADHRVFP--STQVPLLLQALLSCLEKRGLDTEGILRVPGSQARVKGLEQKLERDFYAGLVSWDKVHP----NDASDLLKRFLRKLPAPLLTAEYLPAFAAVPNIPDLKQRLQALHLLVLLLPEPNRNTLKALLEFLRKVAAQEQHNKMTLWNVSTVMAPNLFLPRGRPP--KLAQG-EKQLAEGAAEVVCMMVQYQDLLWTVASFLVAQVRKLNDSNCRRSQLCDGGLKTWLRRTHVDRDKARNGLEATPKVATIQVPATGPSMDLLQVPLSPSTRVTHVLKLFTEHLNPGSQPEEGSETSNSLLSDNTKKKPATFLVYEVGGNIGEHRLDPDAYLLDLYRANPHGEWVIRQSPT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9Q6X9-1", "uniprot_id": "RHG40_MOUSE", "id": "E9Q6X9-1", "name": "Rho GTPase-activating protein 40", "aln": "MTEPSLLPAAKMEGLALLP----LTSPCPRIPRARISRQ---PGRWAHLGCSPGLSTG-PTNLQQHPQKPRPADCSHSRLSWAESLSMDGFWMEVERIQQRAE-VKKEDCGEGRSQLL-EGDTESQWLQDTG-LSGLAGGLGLDG----DHQGLLSTLTQTQVAAVCRRLDIYARSARRRQKAPVRDVRDIFGVFTSRELAPEN-----------GVSGMKWTKINSEDSASPLRSAEPGGPQELAGMEEVFNMDSAYSEQAAVLLQ---RAWPSPGGTTAWGKGPLPRFRIPKGRLG---------VTRIGDLSSRDMKKIPPLALIELTALYDILGLDLKRCKGGKWKGPDSG-LFGVPLHSLLEADHRVFP--STQVPLLLQALLSCLEKRGLDTEGILRVPGSQARVKGLEQKLERDFYAGLVSWDKVHP----NDASDLLKRFLRKLPVPLLTAEYLPAFASVPDIPDLKQRLQALHLLVLLLPEPNRNTLKALLEFLRKVAAQEQHNKMTLWNVSTVMVPSLFLPRGRPP--KLTKG-GKQLAEGAAEVVCMMVQYQDLLWTVASFLVAQVRKLNDSNGRRSQLCDGGLKTWLWRTHVDRDKAGEGLEATPKVAKIQVQATWPSMDLLQVPLNPSTRVTHVLKLFTEHLNPGSQPEEGSENPNSLLSHNT--KPVTFLVYEVGGNIGERRLDPDAYLLDLYRANPHGEWVIRQSPT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5TG30-1", "uniprot_id": "RHG40_HUMAN", "id": "Q5TG30-1", "name": "Rho GTPase-activating protein 40", "aln": "MAEPALLPAAQMERLAPGP----LASPCPRIPRARIARRC--AQRWADLGCSSGPSSGRMDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDE-LREEDSGGNEGQLPEEGEAESQWLQDTG-LSGLLGGLGLDG----DHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPVRDVRDVFGVFNSGKMSSEN-----------GDSGMKGAQLSSGASKFPPAAE-PGGLQEQAGREEAFNMDSAYSEQAAVLLQ---RSRPSRGGTSAWGKCSLPKFTVPKGRLG---------VTRIGDLSLQDMRKVPSLALIELTALCDILGLDLKRSKAGKWKAAETR-LFGVPLDSLLEADHKVLP--STQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHH----NDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPP--KLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVRKLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQV--VWPIKDPLKVPLTPSTKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPDAYLLDLYRANPHGEWVLKQNPT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8T0G4-1", "uniprot_id": "CONU_DROME", "id": "Q8T0G4-1", "name": "Rho GTPase-activating protein conundrum", "aln": "MNSNTDLHHSDDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCS-IGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVES-----------------QKTMMGKKGWHRHRNSNEITAK------------PSGKASNVGVGHDSTVINKYSTNLKHLHP-------------------------FVI-------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . : * :. : :: * * . * . .* . . :. * : . .: . ::: : . :: * :: :* . . .. * .* . . . . : .. *:* : .* : :** :. *: :. . .:* . : : * * : :: * * :* . ::. . .. ** :. : * . .. :: . : . .: .* : :* **::: .: :**::: * :.*.: * * : : ****.:.:*:. *::* *: ***.*: *:. * :** **:**: * : :.: * ::** ** . . *::. :: *.****::*:** **** * : * :*.:.* ::.* :* :** ***:*::**.*:. : :: ***.: **:*:*.*.:* : * : . . ::* ...:. ::: : *: *.. *:.: ** : : .*.: : : *. * . :* : .: * : :** * ::: ", "identical_positions": 114, "similar_positions": 197, "identity": "15.79%" }, { "cls_id": "homologset.agr.HGNC:16227", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M1F2-1", "uniprot_id": "A0ABK0M1F2_RAT", "id": "A0ABK0M1F2-1", "name": "", "aln": "---MAQKRINSRTQFAGHKLQVHMSS---GAEKNLKPSTLPPLRQAKGHSKRKTKSVTKIQPVAQSQVSVDMTTAT-KTPRALRRRDQPHHGKVQAK--VRLMKSMLRNQRTSLQELYSHEGYLSKLNQELIKTILETEDSTALSVREMLQQQNILGNIIDILEYSNKKRVQELRSEFQEWKEKEESKTNTLQWEVEQLNSEIRKANEEVNLLSTYMDHEYPIRLVQIANHVRLVQQAKDSQQDELDNLREMREKVLAFFSNIIQEKKRRILKSLVVKTQEPHENRLLLKTRDSRRLQRCVLWFEELIKQLKEEIPMLISEVEQMYAEIWNPREAVFKDVLLQRPKCTPDMAVELNIPTQELFPF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NUD7-1", "uniprot_id": "CT096_HUMAN", "id": "Q9NUD7-1", "name": "Uncharacterized protein C20orf96", "aln": "MAHVLQKPKHSGTHSIVQEFQVPDYVPWQQSKQETKPSTLPPVQQANSLHTSKMKTLTRVQPVFHFKPTTVVTSCQPKNPRELHRRRKLDPGKMHAK--IWLMKTSLRSGRAALRELRSRENFLSKLNRELIETIQEMENSTTLHVRALLQQQDTLATIIDILEYSNKKRLQQLKSELQEWEEKKKCKMSYLEQQAEQLNAKIEKTQEEVNFLSTYMDHEYSIKSVQISTLMRQLQQVKDSQQDELDDLGEMRRKVLESLSDKIQKKKKKILSSVVAETQRPYEEALLQKMWESQDFLKCMQRFREIIDQFEENMPVLRAEVEELQAQTREPREVIFEDVLLRRPKCTPDMDVILNIPVEEPLPF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7TF22-1", "uniprot_id": "A0A8N7TF22_DANRE", "id": "A0A8N7TF22-1", "name": "", "aln": "--------------MIGRDMWSLHSVDYRKWERSTSSKHLLWTAPIHKSDISSNKAGKRSSPTLKPGKSLNTVHNDFSTLPKLLTRRKTESVEQEKKDCIKTLMLLIRSRKEAIKDLEEHCEQLQERNLQVARSIVDTDRNSVSKANELLVQSQQMRRSMTALKRWDDSLIKSAKADLIATEEASHTHLSGLQKQLDVVKAEVLKAQKELRFLKTYRDMEFPVKVLQIADMERKLDQLKKLQQNEQEDVTLLFKKEMESLERCQKQREQEVLSAIAEKHVSHIPPIVKLMTSQNYKMKEQISLHRKVIMELELKKEDITKSIQELQLSRPNIKRKIFPDVFLKSDKCTPDMDVHLNIPHEDLLPV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.: ::. ... * : . *: .: .*. : : . .. * * : . : . * : : :*. : ::::* .: *.: * :: .:* : : .:. .. :* *.: : : *: :.. ::. :::: :* .. : . *: : : ::::: *:::*:.:*.** * *:.:: :**: * ::* *. **:* ::: : .* : :. :::::.:*.::. : : :. : . : ..::* ::: : : .:::: . : :. :* **:*: ****** * **** :: :*.", "identical_positions": 50, "similar_positions": 146, "identity": "13.7%" }, { "cls_id": "homologset.agr.HGNC:16228", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WTQ6-1", "uniprot_id": "TRIB3_RAT", "id": "Q9WTQ6-1", "name": "Tribbles homolog 3", "aln": "----------------------------------MRATSLAASADVPC-------------------------RKKPLEFDDNIDVECPVLKRVRDEPEPGPTP-----SLPPASDLSPAVAPATRLGPYILLEREQGNCTYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLG----------------SQLLYTFFTKTHG----------DLHSLVRSRRGIPEPEAAALFRQMASAVAHCHKHGLILRDLKLRRFVFSNCERTKLVLENLEDACVMTGPDDSLWDKHACPAYVGPEILSSRPSYSGRAADVWSLGVALFTMLAGRYPFQDSEPALLFGKIRRGTFALPEGLSASARCLIRCLLRREPSERLVALGILLHPWLREDC---------SQVSPPRSDRREMDQVVPDGP-----QLEEA--EEG--EVGLYG------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4K2-1", "uniprot_id": "TRIB3_MOUSE", "id": "Q8K4K2-1", "name": "Tribbles homolog 3", "aln": "----------------------------------MRATPLAASADVSC-------------------------RKKPLEFDDNIDAKCPVLKRVRDEPEPGPLPSLLPPSPPPASDLSPAVAPATRLGPYILLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLG----------------SRLLYIFFTKTHG----------DLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWLREDH---------GRVSPPQSDRREMDQVVPDGP-----QLEEA--EEG--EVGLYG------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96RU7-1", "uniprot_id": "TRIB3_HUMAN", "id": "Q96RU7-1", "name": "Tribbles homolog 3", "aln": "----------------------------------MRATPLAAPAGSLS-------------------------RKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAG----------------TQLLYAFFTRTHG----------DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDP---------MPLAPTRSHLWEAAQVVPDGL-----GLDEAREEEGDREVVLYG------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V3Z1-1", "uniprot_id": "TRIB_DROME", "id": "Q9V3Z1-1", "name": "Tribbles", "aln": "MDNSSGQNSRTASSASTSKIVNYSSPVSPGVAAATSSSSSSSSSGMSSSQEDTVLGLFTPKKEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQPVKLIQQRYLISAQPSHISAAVAAKTPASYRHLVDLTASN--LRCVDIFTGEQFLCRIVN-EPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQMAQNANGLSTEPEPDTDVDMG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. ::.:. . *:* : .. * :* . ... :.***. : . *:: .. :.:. ** :: *:: . * .* :* *.. * : : : :* ..: :. ::*: :* : : *.** :*:*:. :: **::*::****** ** * : *.** *.**.: :: * **:* ** .** *..**:*..: :*.*:.**:***** *:***.*:*** :. *: **:* :* ** ..* *: .***:: :**:.* *:* ****:: :: *. * ...*. * :. :: : ", "identical_positions": 96, "similar_positions": 118, "identity": "19.71%" }, { "cls_id": "homologset.agr.HGNC:16229", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5HZK2-1", "uniprot_id": "NRSN2_MOUSE", "id": "Q5HZK2-1", "name": "Neurensin-2", "aln": "---------MSCSRPCVCSHGTSVEESTWYGFDFYPN----------LFYNDWLGTTTLPYNPERIPIRYINRP---WPSL--CWKVTVAVASLFLLLGVAALTTGYAVPPKLELVNESKFSSMEDPVADYN----------QALMTCRVVGATLCGVAG-----------IMLAVCLFLIASGWMF----------------QDIKAEPLVTETDSPVEVFRDEPEK-LSPAFHETSSQSPFLTPPS---------PFGQQSVQTSQPQRDL-----------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9GZP1-1", "uniprot_id": "NRSN2_HUMAN", "id": "Q9GZP1-1", "name": "Neurensin-2", "aln": "-------MMPSCNRSCSCSRGPSVEDGKWYGVRSYLH----------LFYEDCAG-TALSDDPEGPPVLCPRRP---WPSL--CWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYN----------QALGTCRLAGTALCVAAG-----------VLLAICLFWAMIGWLS----------------QDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQSWFSPPAS---------PFGQSSVQTIQPKRDS-----------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABZ3NNL1-1", "uniprot_id": "A0ABZ3NNL1_RAT", "id": "A0ABZ3NNL1-1", "name": "Transcription factor SOX", "aln": "MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRATGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSSEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVASGEEPLGFLSRMPPGPTGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . *.:.* . * :.:.: . : *: .* * * . *:.. : * * * ..* *: : . .. . . * .* .* *. :* : *: : *. .:* ..: * . :***: . ..:. .. . * * .:: .** ", "identical_positions": 29, "similar_positions": 58, "identity": "9.24%" }, { "cls_id": "homologset.agr.HGNC:1623", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P42932-1", "uniprot_id": "TCPQ_MOUSE", "id": "P42932-1", "name": "T-complex protein 1 subunit theta", "aln": "MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVISGYEIACKKAHEILPELVCCSAKNLRDVDEVSSLLRTSIMSKQYGSETFLAKLIAQACVSIFPDSGN------FNVDNIRVCKILGSGIYSSSVLHGMVFKKETEGDVTSVKDAK---IAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADIALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVQEEMGHCDSVYLSEVGDTQVVVFKHEK-EDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVH--------QEGNKNVGLDIEAEV-PAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWD----DDQND------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ACB8-1", "uniprot_id": "D4ACB8_RAT", "id": "D4ACB8-1", "name": "T-complex protein 1 subunit theta", "aln": "MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVITGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLRTSIMSKQYGSEEFLAKLISQACVSIFPDSGN------FNVDNIRVCKILGSGVYSSSVLHGMVFKKETEGDVTSVKDAK---IAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEK-EDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVH--------QEGNKNVGLDIEAEV-PAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWD----DDQND------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P50990-1", "uniprot_id": "TCPQ_HUMAN", "id": "P50990-1", "name": "T-complex protein 1 subunit theta", "aln": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGH------FNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAK---IAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEK-EDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVH--------QEGNKNVGLDIEAEV-PAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWD----DDQND------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B7F7-1", "uniprot_id": "A0ACD6B7F7_DANRE", "id": "A0ACD6B7F7-1", "name": "T-complex protein 1 subunit theta", "aln": "MALHVPKAPGFAQMLKDGAKHYSGLEEAVFRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRMGLSVSEVIEGYEMACKKALEILPDCVCSSAKNLHDLEEATAMIRSAVMSKQYGNEDFLANLIAQACVSIFPESGS------FNVDNVRVCKILGCGLNSSTMLHGMVFKKEAEGDVTSVKDAK---IAVFSCPFDCTVTETKGTVLIKNADELMNFSKGEEDLMEAQVKAIADSGASVVVTGGKVADMALHYANKYKLMVVRLNSKWDLRRLCKTVGATALPRLTSPTPEEMGRCDSVYLSEVGDTQVVVFKHDK-EDGAISTLVIRGSTDNLMDDIERAIDDGVNTFKVLVRDA--RLCPGAGATEIELAKHITSYGESCPGLEQYAIKKYAEAFEALPRALAENSGVKGNELISKLYATH--------HEGNKNSGFDIEGEG-PAVRDMMEAGILDPYLVKYWGIKLATNAAITVLRVDQIIMAKPAGGPKAPKQQGHWDKDGWDDEPDKFDTHH", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P47079-1", "uniprot_id": "TCPQ_YEAST", "id": "P47079-1", "name": "T-complex protein 1 subunit theta", "aln": "MSLRLPQNP-NAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGN----WDQED------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:*::*: * * ::*:* : :*. : : :.* * :** * *: ** * **:::*:* *:::******:****:: ***.*::***:. *: ::*****:*:::** **:::*:*: :***. *:* **::* : : : * : * . .: .* :* :::. : **:**.* :*::*:::* ::* : ****.:** **:* .: .*::::****::*.**.*.*:.: * :**::**:* ********::.*:*:::******. ::* :* **. *.. :*:*. *.::**** *:* :::::: **::*****:. ***.**:* .*. **:* ::* *:*. :*.***::: * . **:::**:*:* :******:**** :.* * : :* **.******* .:**.*** *** * ***::* ***.:**:***.:*:. **::.:**:.* : .: *.**:.* .*:*: * .* * * :.*::**:** *** :******* ****:.*. : *: * ", "identical_positions": 240, "similar_positions": 192, "identity": "41.45%" }, { "cls_id": "homologset.agr.HGNC:16230", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BPK2-1", "uniprot_id": "ZCHC3_MOUSE", "id": "Q8BPK2-1", "name": "Zinc finger CCHC domain-containing protein 3", "aln": "MATGGGAEEESQRGRPQLPLPARPVARVEEPEGVREKMGWAQVVKNLAEKKGDFREPR--RRDE--TGSGASGGLGSPGGLATPNPGDFPPAARGDPKGRRRDPTGEASDAYRKKSASGAGDPSRRKKAEVTAAMATPARPGTTEDATERPLQDEPP-AAGPGKGRFLVRICFQGDESACPTRDFVVGALILRSIGMDPDDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKRELEDCWENFVVLGRSRSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGTCTQDRCFRCGEEGHLSPYCRKVIVCNLCGKRGHAFAQCPKAVHNSVTAQLTSVAGH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZZ10-1", "uniprot_id": "D3ZZ10_RAT", "id": "D3ZZ10-1", "name": "", "aln": "MATGSGAEEEPQRGRPELPLPARPVARAEESEGVREKMGWAQVVKNLAEKKGDFREPR--RRDE--AGSGASGGLGSSGSLAAPNPGDFPPAARGDPKGRRRDPTGEAADAYRKKGASSAGDPSRRKKADVSAAMPTPARSGATEDATERPLQDEPP-AAGPGKGRFLVRICFQGDESACPTRDFVVGALILRSIGMDPDDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKRELEDCWENFVVLGRSKSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGTCTQDRCFRCGEEGHLSPYCRKVIVCNLCGKRGHAFAQCPKAVHNSMAAQLTGLAGH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NUD5-1", "uniprot_id": "ZCHC3_HUMAN", "id": "Q9NUD5-1", "name": "Zinc finger CCHC domain-containing protein 3", "aln": "MATGGGAEEERKRGRPQLLPPARPAARGEEADGGREKMGWAQVVKNLAEKKGEFREPRPPRREEESGGGGGSAGLGGPAGLAAPDLGDFPPAGRGDPKGRRRDPAGEAVDPRKKKGAAEAG--RRKKAEAAAAAMATPARPGEAEDAAERPLQDEPAAAAGPGKGRFLVRICFQGDEGACPTRDFVVGALILRSIGMDPSDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKREQEDCWENFVVLGRSKSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGSCTQDRCFRCGEEGHLSPYCRKGIVCNLCGKRGHAFAQCPKAVHNSVAAQLTGVAGH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****.***** :****:* ****.** **.:* ******************:***** **:* *.*.*.***....**:*: ******.***********:*** *. :**.*: ** *:* .:***.****.* :***:********. *******************.*********************.************************************ *************:*************************************************************************************************:********************* ***********************::****.:***", "identical_positions": 342, "similar_positions": 39, "identity": "84.44%" }, { "cls_id": "homologset.agr.HGNC:16231", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BME9-1", "uniprot_id": "CBLN4_MOUSE", "id": "Q8BME9-1", "name": "Cerebellin-4", "aln": "MGSARRALSVVPAVLLILVLP---VWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPLGISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIYSFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLEKGNLLGGWQYSTFSGFLVFPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ABJ2-1", "uniprot_id": "D4ABJ2_RAT", "id": "D4ABJ2-1", "name": "", "aln": "MGSARRALSVVPAVLLVLVLP---VWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPLGISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIYSFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLEKGNLLGGWQYSTFSGFLVFPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NTU7-1", "uniprot_id": "CBLN4_HUMAN", "id": "Q9NTU7-1", "name": "Cerebellin-4", "aln": "MGSGRRALSAVPAVLLVLTLPGLPVWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPLGISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIYSFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLEKGNLVGGWQYSTFSGFLVFPL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***.*****.******:*.** ****************************************************************************************************************************************************************:****************", "identical_positions": 193, "similar_positions": 5, "identity": "96.02%" }, { "cls_id": "homologset.agr.HGNC:16232", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91W29-1", "uniprot_id": "COX42_MOUSE", "id": "Q91W29-1", "name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "aln": "---MFSRAARSLVMRTG-LRTRGT----GTHSPGDAAGS-QRRMTPY-VDCYAQR-SYPMPDEPFCTELSEEQRALKEKEKGSWTQLSQAEKVALYRLQFHETFAEMNHRSN-EWKTVMGCVFFFIGFTALVIWWQRVYVFPKKVVTLTEERKAQQLQRLLDMKSNPIQGLAAHWDYEKKEWKK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q91Y94-1", "uniprot_id": "COX42_RAT", "id": "Q91Y94-1", "name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "aln": "---MFSRATRSLVMKTGGLRTQG------THSPGSAASSSQRRMTPY-VDCYAQR-SYPMPDEPYCTELSEEQRALKEKEKGSWAQLSQAEKVALYRLQFHETFAEMNHRSN-EWKTVMGCVFFFIGFTALVIWWQRVYVFPKKVVTLTEERKAQQLQRLLDMKSNPIQGLSAHWDYEKKEWKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96KJ9-1", "uniprot_id": "COX42_HUMAN", "id": "Q96KJ9-1", "name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "aln": "---MLPRAAWSLVLRKGGGGRRG------MHSSEGTTRG-GGKMSPY-TNCYAQR-YYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSN-EWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R6I1-1", "uniprot_id": "F1R6I1_DANRE", "id": "F1R6I1-1", "name": "Cytochrome c oxidase subunit 4", "aln": "---MLSSRALVRGLQSGFWRRLS------TSSGIWAAHTHDVDVTDCSVPQYNNRLDTPLPDVPFVRNLSAEQKKLKEKEKGPWTQLSKEEKLAIYRLTHELSFPEMRKGSK-EWMTVLAGVFFFLGFTGLLVWWQRVFVYGDVPHTLSQEWIEKQTQRMLDMKVNPITGFAHKWDYEKKQWK-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P00425-1", "uniprot_id": "COX5B_YEAST", "id": "P00425-1", "name": "Cytochrome c oxidase subunit 5B, mitochondrial", "aln": "------------MLRTSLTKG---------ARLTGTRFVQTKALSKATLTDLPER-WENMPN----LEQKEIADNLTERQKLPWKTLNNEEIKAAWYISYGEWGPRRPVHGKGDVAFITKGVFLGLGISFGLFGLVRLLANPETPKTMNREWQLKSDEYLKSKNANPWGG------YSQVQSK-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P00424-1", "uniprot_id": "COX5A_YEAST", "id": "P00424-1", "name": "Cytochrome c oxidase subunit 5A, mitochondrial", "aln": "------------MLRNTFTRAGG------LSRITSVRFAQTHALSNAAVMDLQSR-WENMPS----TEQQDIVSKLSERQKLPWAQLTEPEKQAVWYISYGEWGPRRPVLNKGDSSFIAKGVAAGLLFSVGLFAVVR-MAGGQDAKTMNKEWQLKSDEYLKSKNANPWGG------YSQVQSK-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VIQ8-1", "uniprot_id": "Q9VIQ8_DROME", "id": "Q9VIQ8-1", "name": "Cytochrome c oxidase subunit 4", "aln": "MALRLLNSAVLRQLASQLPKSAQVGSVAAVHTLDKIGKREIVGYGWNGTACYADRVDYPLPAVR-FREPTNEINALRAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSG-EWKLHLGVSLLFCAAAIWVAVLMNIFVYDELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWKN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . .* :* : * ::: * *. * * : . .. . : : : . . *: * . : : . : ** * *.: : * ", "identical_positions": 14, "similar_positions": 28, "identity": "7.61%" }, { "cls_id": "homologset.agr.HGNC:16233", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZMS9-1", "uniprot_id": "D3ZMS9_RAT", "id": "D3ZMS9-1", "name": "", "aln": "MSCPLGKKALPQAMLLLLLSFQVLITPVTKANEETDKSVN-----FIP-TVEFAVNTFNQKSQDEYAYRMEHIMSSWREEVDHPIVFSMRLRLRRTICKKFEESLDICPFQESHDRNNTFTCLFTVGTLPWITEFQLFKNVCS----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0H6-1", "uniprot_id": "CST9_MOUSE", "id": "Q9Z0H6-1", "name": "Cystatin-9", "aln": "MSCPLRKKALPLTMLLLLLSFHVLITPVSKANKETNRSVH-----FIP-TVEFAVNTFNQESQDEYAYRMEHIMSSWREKVNFPTVYSMRLQLRRTICKKFEESLDICPFQESHGLNNTFTCLFTVGTYPWITKFKLFRSVCS----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H4G1-1", "uniprot_id": "CST9L_HUMAN", "id": "Q9H4G1-1", "name": "Cystatin-9-like", "aln": "MLGLPWKGGLSWALLLLLLGSQILLIYAWHFHEQRDCDEHNVMARYLPATVEFAVHTFNQQSKDYYAYRLGHILNSWKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNNTFTCFFTISTRPWMTQFSLLNKTCLEGFH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * .*. ::*****. ::*: . : ::: : . : ::* ******:****:*:* ****: **:.**:*:*: *:**.* * ** * ***:.:* * **** ******:**:.* **:*:*.*:...* ", "identical_positions": 64, "similar_positions": 42, "identity": "43.54%" }, { "cls_id": "homologset.agr.HGNC:16234", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZQ48-1", "uniprot_id": "D3ZQ48_RAT", "id": "D3ZQ48-1", "name": "CCCTC-binding factor", "aln": "MAAAEVPVASGHFTQIKEQKLKPGDLEEEKEEGGVQRGEAQEGAVEEAEAEP-------------QELPSRAPVESDRRILTLQTLHLTSQDVHLQGLGWLSVPHSEELSMTVPQAESILQLPSVLWLDPEPPLSLQHCVTVSIPEELYPPEMLELRHFHLLRENVPEDDEENQESTSNLEESTAPKK--------------PEED-EKDQLLPQGGTDKKEERFLFVEMKPREGKD-EIVLTISHLSLEEQQDPPAAKHTSAPGAKAAKPKPQRQTKGRPRT------------FQCDTCPFTSSKLSTFNRHIKIHSDERPHLCHLCLKSFRTVTLLRNHVNTHTGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSLCKYASVEASKLKRHIRSHTGERPFQCSQCAYASKDTYKLKRHMRTHSGEKPYECPTCHARFTQSGTMKIHIAQKHGENVPKHECPHCATIIARKSDLRVHLRNLHGHSPEEIKCRYCPAAFHERYALLQHQRTHKNEKKFKCKQCDYACKQERCLTAHMRTHTGERPFSCLTCNKHFRQKQLLTVHLRKYHDPSFVP-----SVHLCLKCGKGFSRWSNLQRHRKKCDPEHEKSAPSRNGRP--VTR----------------AQASEEGAEHDKDVATQESATSGEPRPPEEQALGHQGESAAGSPSPDQGLTCEMIFNMMDK----------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2APF3-1", "uniprot_id": "CTCFL_MOUSE", "id": "A2APF3-1", "name": "Transcriptional repressor CTCFL", "aln": "MAAAEVPVPSGYFTQIKEQKLKPGDLEEEKEEDGVQRVEAQEGVVKEVEAENSC-----------LLLEARAPVESDRRILTLQTVHLESQDVHLQGLGWLSVPHSEELSGTVPEAEGILQLPSVLWLDPEPQLSLQHCVTVSIPEELYPPEELQRIHFHLLRENVLMAEE-NPELTPDLDESTALKK--------------PEED-EKDQLPPQGETDKREERLLLLEMKPKEGKDDEIVLTISHLSLEEQQDPPAANQTSVPGAKAAKPKRRRQTKGKPQS------------FQCDTCPFTSSKLSTFNRHIKIHSNERPHLCHLCLKAFRTVTLLRNHVNTHTGTRPHKCRDCDMAFVTSGELVRHRRYKHTYEKPFKCSLCKYASVEASKMKRHIRSHTGERPFQCCQCAYASRDSYKLKRHMRTHSGEKPYECPTCHVRFTQSGTMKIHIAQKHGENVPKYECPHCATIIARKSDLRVHLRNLHSQSPEEMKCRYCPAGFHERYALIQHQRTHKNEKKFKCKQCDYACKQERCLKAHMRMHTGEKPFSCLACNKHFRQKQLLTVHLRKYHDPNFVP-----NLHLCLKCDKRFSRWSNLQRHRKKCDPEHETLAPNKDRRP--VTR----------------TQASEGEAGHKE----------GEPQCPGEQALGHQG-EAAGSQSPDHGLTCEIIFNMMDK----------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NI51-1", "uniprot_id": "CTCFL_HUMAN", "id": "Q8NI51-1", "name": "Transcriptional repressor CTCFL", "aln": "MAATEISVLSEQFTKIKELELMPEKGLKEEEKDGVCR-EKDHRSPSELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQEGVQVVVQQPG-----PGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASE-DSKLAVSLAETTGLIK--------------LEEEQEKNQLLA----ERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAKSTK--NQRKTKGAKGT------------FHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIP-----TVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRR--TRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK----------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VS55-1", "uniprot_id": "Q9VS55_DROME", "id": "Q9VS55-1", "name": "", "aln": "--MPRRTKKDEDPEDLQTFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHT-SDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQARLAASEKQPMIINQRLRSQRGTKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGDEEVLVKHEPSANSKISAKNCFGFEDDDDYEEYGDGENEVDGASQEFLQLMDMIEQDS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. . . .:: . : :.. * . : . : : . *::. : :: .: . . :. . . .:: .*: . : . .* : .: . . .: . * .. : : : * ::* . .: . .** .. .: * :* .:: . .. . .::.* : : * * :*:*: :.** : * * .. * :* ::**: . *:**:*** *.:*:** *: **.******** ***** ***.**: *.***** :*::**: .******:** :*:***:* :****** *:*** *:* *: *****.::* * : : * .:* :*.* .**:*****::::* * :.** * : :** * ::*:.** :.** *.**. :* : :*: * .*:** * * : ***:*** *:. *: .: * .:: * .* : *:: ** ** :. . : : . .. * . :. .. :::* : ", "identical_positions": 150, "similar_positions": 179, "identity": "18.27%" }, { "cls_id": "homologset.agr.HGNC:16235", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60905-1", "uniprot_id": "DNJC5_RAT", "id": "P60905-1", "name": "DnaJ homolog subfamily C member 5", "aln": "-MADQ-RQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHPDKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVVCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVS-PE------DLEAQL-------------------------QSDEREATDTPIVIQPAS--------------ATETTQLTADS-HPSYHTDGFN---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P60904-1", "uniprot_id": "DNJC5_MOUSE", "id": "P60904-1", "name": "DnaJ homolog subfamily C member 5", "aln": "-MADQ-RQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHPDKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVVCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVS-PE------DLEAQL-------------------------QSDEREATDTPIVIQPAS--------------ATETTQLTADS-HPSYHTDGFN---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3Z4-1", "uniprot_id": "DNJC5_HUMAN", "id": "Q9H3Z4-1", "name": "DnaJ homolog subfamily C member 5", "aln": "-MADQ-RQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHPDKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFVFCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVS-PE------DLEAQL-------------------------QSDEREATDTPIVIQPAS--------------ATETTQLTADS-HPSYHTDGFN---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FF34-1", "uniprot_id": "E7FF34_DANRE", "id": "E7FF34-1", "name": "DnaJ homolog subfamily C member 5", "aln": "-MAEQQRQRALSTSGESLYVVLGVEKNTAQEDIKKSYRKLALKFHPDKNPNNPEAADKFKEINNAHAILSDPTKRNIYDKYGSLGLYVAEQFGEENVNTYFVLSSWWAKALFIFCGVATGCYFCCCLCCCCNCCCGKCKPHPPHSDDPDFYVS-PE------DLEAQM-------------------------QSDERDGS-SPIMMQPSS--------------ATESTQLTADSHHTSYRTDANY---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q03751-1", "uniprot_id": "DNJC5_DROME", "id": "Q03751-1", "name": "DnaJ homolog subfamily C member 5 homolog", "aln": "MSAPGMDKRKLSTSGDSLYEILGLPKTATGDDIKKTYRKLALKYHPDKNPDNVDAADKFKEVNRAHSILSDQTKRNIYDNYGSLGLYIAEQFGEENVNAYFVVTSPAVKAVVICCAVITGCCCCCCCCCCCNFCCGKFKPPVNESHDQYSHLNRPDGNREGNDMPTHLGQPPRLEDVDLDDVNLGAGGAPVTSQPREQAGGQPVFAMPPPSGAVGVNPFTGAPVAANENTSLNTTE-QTTYTPDMVNQKY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :* *****:*** :**: *.:: :****:*******:******:* :*******:*.**:**:* *******:*******:**********:***::* .**:.: *.: * * *** *** * **** ** ...: ::. *: *: ::: *. *: . . : : *.* *.*.*.*.: . :.:* .* ", "identical_positions": 102, "similar_positions": 56, "identity": "40.8%" }, { "cls_id": "homologset.agr.HGNC:16236", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B4F7B7-1", "uniprot_id": "DUS15_RAT", "id": "B4F7B7-1", "name": "Dual specificity protein phosphatase 15", "aln": "MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFG--------------------------------------------------------------EIPFRDEE----DLRALLPLCRRCRQGPGTSAPSA------------------------TTASSAASEGTLQR-------------------LVPRSPRESHRP------------LPLLARVKQTFFCLPRCLSRKGGK------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R4V2-1", "uniprot_id": "DUS15_MOUSE", "id": "Q8R4V2-1", "name": "Dual specificity protein phosphatase 15", "aln": "MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTIVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFG--------------------------------------------------------------EIPFRDEE----DLRALLPLCRRCRQGSATSAASA------------------------TTASSAA-EGTLQR-------------------LVPRSPRDSHQP------------LPLLARVKQTFFCLPRCLSRKGGK------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1R2-1", "uniprot_id": "DUS15_HUMAN", "id": "Q9H1R2-1", "name": "Dual specificity protein phosphatase 15", "aln": "MTEG---VLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSG------------------------------------------------------------AQCPPMTSATCLLAARVALLSAALVREATGRTAQRC------------------------RLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQL----IMADVQVQLRPGSSSCTLSASTERPDGS-----STPGNPDGITHLQCSCLHPKRAASSSCTR--------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LWL2-1", "uniprot_id": "DS22A_DANRE", "id": "Q1LWL2-1", "name": "Dual specificity protein phosphatase 22-A", "aln": "MGNGMNKVIDGLYLGNIRDSENRDSLSRNGITHILSVCNNAKPVLEDMTYLCINAADASSQNLSQHFKESIRFIHECRLNGGACLVHCLAGVSRSTTVVVAYLMTVTSYGWQECLTAVKAVRSFVGPNYGFQQQLQEFQMKQVSEYQAWLRASYR--------------------------------------------------------------SSPFKDQE----QVEALLSLFAEQQQ-----------------------------------------------------------------------QGQQNDP--------------EWMSQGSRIYPLSYNQYSASGS-----NR-----------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9PI51-1", "uniprot_id": "M9PI51_DROME", "id": "M9PI51-1", "name": "Dual specificity protein phosphatase 15", "aln": "MNWHMGKVLPGLYVGNYRDSKDHAQLERFKISHIIAIHDSPRRLLPDKHYLCVMASDTPDQNLSQYFSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGRAVANPNAGFQSQLQEFEQFKLSEERRRLRERFPSSALEQLDRTKVATALDNYQELLQNRDICEGNCSRGEKCPTGVCNMDPTKGLFRRRPSNASTHSRLRAQSSNANASSSSLSVSSAAAQSCPTSPKNSPLPIVRRSVGNERIPEDEIVLEQPPTTSREAAEYAAAFEDARREQEQRQLQQQQQLSRSQRSPRPVNSSREAPRVSSAGSRRESAAREGNGSAQLQRSASTVSGFGVRPRSSPAGLHAYTGSVPSSVHGSRVDLRDADKGSAIYLGCSAPRASTLSISSSRGSSGGSAPPSPCHTPPASPRHGVKRSTSLVKKPR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *: ***:** *::: .* * *:**::: :..: :* * ** : .:*:.. :.::*. . *** .**. * *:**:**:***.*:. **:**.* .*:: * .::* *....** **:.**:** . .: . * : : . . * .* ", "identical_positions": 54, "similar_positions": 59, "identity": "12.08%" }, { "cls_id": "homologset.agr.HGNC:16239", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AFK4-1", "uniprot_id": "A2AFK4_MOUSE", "id": "A2AFK4-1", "name": "Mitochondrial ribosome-associated GTPase 2", "aln": "-------------------MVSTRLVLARTCTVFEGVLKWAPSTRAVLRPSHLL-LQASCRLLSVGIVDHAKHREPSGKKVLSEKKLKRHFVDHRRVLVRGGSGGSGMSCFHSEPRKEFGGPDGGDGGNGGHIILRVDQQVKSLSSVLSQYQGFSGEDGGSKNCSGRGGATLYIQVPVGTLVK---------------------------------------------------------------------------------------EGDKIVADLSNLG---------DEYVAALGGAGGKGNRFFLANDNRAPVTCTPGQPGQERVLYLELKTMAHAGMVGFPNAGKSSLLRAISNAKPAVASYPFTTLNPHVGIVHY-EGHQQVAVADIPGIIRGAHQNKGLGLSFLRHIERCRFFLFVVDLTLPEPWTQVDDLKYELEKFEEGLSERSHVIIANKIDLPQARA-------RLPQLQARLGQEAIGLSALTGENLEQLLLHLKELHDAHIEAELEQGRQPLRW", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AA18-1", "uniprot_id": "A0A8I6AA18_RAT", "id": "A0A8I6AA18-1", "name": "Mitochondrial ribosome-associated GTPase 2", "aln": "-------------------MVPTRLVLARTCTVFDSVLKWAPSTCAVLKPSQLLPLQASCRLLSVGIVDHAKHREPSGKKLLSEKKLKRHFVDHRRVLFRGGSGGSGMSCFHSEPRKEFGGPDGGDGGNGGHIILRVDQQVKSLSSVLSQYQGFSGEDGGSKNCFGRGGATLYIQVPVGTLVK---------------------------------------------------------------------------------------EGDEIVADLSHLG---------DEYVAALGGAGGKGNRFFLANDNRAPVTCTPGQPGQERVLYLELKTMAHAGMVGFPNAGKSSLLRAISNAKPAVASYPFTTLNPHVGIVHY-EGHQQVAVADIPGIIRGAHQNKGLGLSFLRHIERCRFFLYVVDLSLPEPWTQVDDLKYELEKYEEGLSERSHVIIANKIDLPQARA-------HLLQLQDRLGQEVIALSALTGENLEQLLLHLKVLHDAHIEAELEQGRQPLRW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H4K7-1", "uniprot_id": "MTG2_HUMAN", "id": "Q9H4K7-1", "name": "Mitochondrial ribosome-associated GTPase 2", "aln": "-------------------MAPARCFSARLRTVFQGVGHWALSTWAGLKPSRLLPQRASPRLLSVGRADLAKHQELPGKKLLSEKKLKRYFVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVK---------------------------------------------------------------------------------------EGGRVVADLSCVG---------DEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVAHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHY-EGHLQIAVADIPGIIRGAHQNRGLGSAFLRHIERCRFLLFVVDLSQPEPWTQVDDLKYELEMYEKGLSARPHAIVANKIDLPEAQA-------NLSQLRDHLGQEVIVLSALTGENLEQLLLHLKVLYDAYAEAELGQGRQPLRW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QCB3-1", "uniprot_id": "E9QCB3_DANRE", "id": "E9QCB3-1", "name": "", "aln": "------------------------------------------------MFVRLKILQRSGRTVREALLQREKHTHTLEER-LSEKKLSRCFVDQRRVRLQAGSGGKGASSFHSEPRKEWGGPDGGDGGAGGHIIIRVNRQVKSLSSVSTVYRGRDGEAGGSKNCFGRNANPTYISVPVGTVVR---------------------------------------------------------------------------------------EQGVVLADLSQQD---------QQVTVAYGGAGGKGNRSFLTNENRAPMRATEGQQGQQREIQLELRTMAHAALVGFPNVGKSSLLRAISKARPAVAAYPFTTLNPHVGIVEY-RDHTQVAVADIPGLIPGAHLNRGLGLSFLRHIERCRVLLYVLDMSSPEPWEQFQQLCFELDQYRPLFSQRPHAIVANKMDLPESRA-------NLEALRERISQTVIPVSALTRGNTGELILHLREMYDSYPQAETLP-------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLN0-1", "uniprot_id": "Q9VLN0_DROME", "id": "Q9VLN0-1", "name": "Mitochondrial ribosome-associated GTPase 2", "aln": "---------------------------------------MLFSTGKSFLARFSLNISRNAKPIGLIANYCQVASALRPKKAKSTRKEAQYFSDAKRIRAIGGKGGDGCVSFLQLWCNERAGPDGGDGGHGGHVVFQASNDVRNFNHVGSVLKAEEGEPGSSKDCHGKNAKHSVIKVPIGTVIRN--------------------------------------------------------------------------------------AQGQIVGDLGQAD---------LMFVAARGGAGGKGNRFFTTDKETSPKVSEYGPRGEDLSYTLELRSMADVGLIGYPNAGKSTLLNALTRAKPKVAPYAFTTLRPHLGTVQY-DDHVQLTIADLPGLVPDAHRNKGLGIQFLKHAERCTLLLFVLDASAPEPWTHYEQLMHELRQFGGRLASRPQLVVANKLDVEEGQN-------NFEELQRRLQNPVLGISAKMGHNLGQLLNSIRRGYDRHKDQPQESS------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38860-1", "uniprot_id": "MTG2_YEAST", "id": "P38860-1", "name": "GTPase MTG2, mitochondrial", "aln": "MSIAWSSVFKRELRLERFLPRVYSTKVPDNAPRAADNEQWLETLRPITHPEQKKSDHDVSYTRHINVPLGEVTSVNYLQRYNKHKHSQGNFVDVRIVKCKSGAGGSGAVSFFRDAGRSIGPPDGGDGGAGGSVYIQAVAGLGSLAKMKTTYTAEDGEAGAARQLDGMRGRDVLIQVPVGTVVKWCLPPQKVRELVEREMRKDNNATLRSILGSTAVNLSVSSGSHRKKIQLYRHEMAESWLFKDKAKEYHENKDWFKDLHKKMEAYDHSLEQSELFNDQFPLAGLDLNQPMTKPVCLLKGGQGGLGNMHFLTNLIRNPRFSKPGRNGLEQHFLFELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEK-VKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPISALREENIDVLKKKMFKCARQSEFDK----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: . :: * * : : .* ** * .* .. . ******* ** : ::. : .: : : . .** *.::: * . * **:**::: . :. * ** ** ** * :: * . * * : :**:::*. .::* **.***::*. ::.*:* :. : **** * :* * .: .::**:**:: .* ::*:* **:* **. ::*:* : :* . : * *: . : ::.**:*: : .. : : :** * * : ", "identical_positions": 79, "similar_positions": 95, "identity": "14.93%" }, { "cls_id": "homologset.agr.HGNC:16243", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P20689-1", "uniprot_id": "MYLK2_RAT", "id": "P20689-1", "name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MATENGAVELGTQSLSTDHPPTD--------------------------------------AAGDGSPASEKEP-------SLPDTEKDLGPTNTKKDPGAPDPKKNPDPPSLKKTP-EAPGPEK-KGDSAPASASNQGPSGEGDGGGGPAEG----GTGPP------AVLPQPTATADASIQKLDATQAPSGNQESGEAKAGKKAAECR--EAGRRGSPAFLH----SPSCPAIISCSEKTLAM-------KP-------------LSETTELIFAGVSETPD--PQDPGPAKDEGGTNTLADGKEE---AEAGQAEQAKVQGDTSQRIGFQAVPSERAE-VGQALCLTAKEED-----------------------------------CFQILDDCPPPPAPFPHRIVELRTG-NVSSEFSMNSKEALGGGKFGAVCTCTERSTGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYSAIETSHEIILFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLITKDQSARMSAEQCLAHPWLNNLAEKAKRC--------------NRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCR8-1", "uniprot_id": "MYLK2_MOUSE", "id": "Q8VCR8-1", "name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTENGAVELGSQSLSTEQTPKA--------------------------------------AAGDGPSASEKEP-------SAPATEKDLSPPNAKKDPGAPDPKNNPDPPSLKKDPAKAPGPEK-KGDPVPASASSQGPSGEGDGGGGPAEG----SEGPP------AALPLPTATAEASIQKLDPTQAPSGNQGSGEAKAGKKAAECR--EAGRRGSPAFLH----SPSCPAIISCSEKTLAV-------KP-------------LSETTDLVFTGVSVTPD--PQDPGPVK-AGGTNALAEKKKEEAEKASGQAGQAKVQGDTPQRIGFQAVPSERVE-VGQALCLTAREED-----------------------------------CFQILDDCPPPPAPFPHRIVELRTG-NVNSEFSMNSKEALGGGKFGAVCTCTERATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQSARMSAEQCLAHPWLNNLAEKAKRC--------------NRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1R3-1", "uniprot_id": "MYLK2_HUMAN", "id": "Q9H1R3-1", "name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MATENGAVELGIQNPSTDKAPKG--------------------------------------PTGERPLAAGK-------------------------DPGPPDPKKAPDPPTLKKDA-KAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEG----SAGPP------AALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQ--AAARRGSPAFLH----SPSCPAIISSSEKLLAK-------KP-------------PSEASELTFEGVPMTHS--PTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSE-VGQALCLTAREED-----------------------------------CFQILDDCPPPPAPFPHRMVELRTG-NVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRC--------------NRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A9N0-1", "uniprot_id": "A0AB13A9N0_DANRE", "id": "A0AB13A9N0-1", "name": "", "aln": "------------------------------------------------MSLKDSMKCPVPPSNPTTLEAKVDDLRLKVELLLGSSRSCSMCGTCAQHRALQETLTSQLSTQT-------------------------RLLDSLEKKVMEMRVALEDLTRGLEDRQCERVSVPLVALQRRKSLPVRS--------------------------------------SAEEVYICLDRDRKTMPHAFNKPSEKGILLEVNENNGTRREDHQAKKDSTEVKVEPTLPIKRENGTSSVTPRSEQTQKMNKTENKSMPPTQNHVLIPIRTP------AIASQKTEAQEIRKVPPPNIKVPVAAAVIIPNTTGQTCTESVNVTPANHILPKTTV----TPAAPPLVNNNTPKLTVSEVPKDFKPSHKYPQTSLPPSVAAQRSEQTPVNMPTTKTTTPQDAALFPPTHKPPKTVGLSVTTATKEASSLRQVHSCPNSLQRLQVPGLKADLVHTVTSTLTSKKRATETVGAAKLTSDGIQIKISSATDKNSAQTKSYNPPKLCFKVIDDVSPQPAPFAHRFVALKSSPPPCDTFSIHTREVLGGGRFGKVHKCTETRTGMRLAAKIINTRNSKERDMALNEMQVMNQLSHPNILQLYEAFEVKNQVVLILEYVEGGELFERIVDESSPLTEVDAMVFVKQICEGVQYMHQMYVLHLDLKPENILLVNRSSHQVKIIDFGLARRYKPREKLKVSFGTPEFLAPEVVNFDFVSFPTDMWTLGVVTYMLLSGLSPFLGDDDGQTLNNVLMGNWYFDEDAFEHVSADARDFVSNLLIRERSGRMSATQCLKHPWLNNIFEKAKSS--------------NIVLKSQVLLKKYMARRLWKKNYIAIAAANRFKKIGSSGSLTSLGI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z7Y7-1", "uniprot_id": "A1Z7Y7_DROME", "id": "A1Z7Y7-1", "name": "", "aln": "MIYIDDSEPEGVLEPAFPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKREDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSN--VTIAKYDFEDECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDEDDEEEVAVQQAKQKDQQQDEELANLCGDAELENKELDATKDNLKNFIVRWETHPNSPYVFDVEGNVIAPLSETSYPHPR------------RTHGADSLSSSRVCSPSPCDSISTLTDDERGDIEDLPEEDESRSAENESPRSVATPINESREKLFPTVATSSPSTPTPQHLFNENFDEFSGSQSTAQQ-------QRSMKSYLHTFDRRNSDTTYLLGRRSSGERVNLADEIRKLSDHLLMLAEINTKLGDANNNGSSSGAPADPPAAAAAAAAPVPTSTAPASVAPSGSTSSKTSEISQEGNRWTSKTTSSSSWNRPTLKGGLFSQASSSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKLSNGNSSSSKSLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSN---YIASNASNSISTSASNPSSTGASNPITTSASNESASSRRAKFRINQMSRDVPVGLPDTHQTVNLEEAANTTKDCLLHLLEKYNETRIRNPVGRHQSISVDWRVSDNLEYRSMSSINAFFQRHNPNGGGHNVRHIQAQLEEKAAGK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : . : . .. * . :. . :: : . . :. .* : . : : *. * . . * .* :.. . :: :* :. :: . : . . . .. : : . : :. . . : : : . . :...: * :. : :. ..* . . :. *. .. .. . :. : .. * : . : : : . . :. : .: : .: . : : : ...: * . *: :. . ** :. .: :.. :.:.::... . : * : . : : :. * . . :.:.. : .. : :. ::*. .* .: .:. : * :: ** : : :..:: :. . : :.. . ...:..::* :. : * ", "identical_positions": 24, "similar_positions": 189, "identity": "2.63%" }, { "cls_id": "homologset.agr.HGNC:16244", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3E2-1", "uniprot_id": "D4A3E2_RAT", "id": "D4A3E2-1", "name": "Probable aminopeptidase NPEPL1", "aln": "--------------------------------------------------------------------------------------------------------------------MAS-----VGLQFQASAGDADPQSRPLLLLGQLQHLHRVPWSHVRGKLQPRVTEELWQAALATLNPNPTDSCPLYLNCATVAALPSRVSRHNSPSAAHFITRLVRTCLPPGTHRCILMVCEQPEVFASACALARAFPLFTHRSG---ASRR-------------TEKRTVMVEFFLVGQD----NGPVEVSTLQCLTNATEGVRLAARIVDTPCSEMNTDIFLEEISQVGRELGITPTIIRDEQLKTKGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAILGAFRAAIKQGPSLPVSCGLQGFKDNLHAVFCLAENAVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIIVDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGQKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLDCEVDAQEDDSVGRDSKRRRLV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NSR8-1", "uniprot_id": "PEPL1_MOUSE", "id": "Q6NSR8-1", "name": "Probable aminopeptidase NPEPL1", "aln": "--------------------------------------------------------------------------------------------------------------------MAS-----VGLQFQASAGDADPQSRPLLLLGQLQHLHRVPWSHVRGKLQPRVTEELWQAALATLNPNPTDSCPLYLNCATVAALPSRVSRHNSPSAAHFITRLVRTCLPPGTHRCILMVCEQTEVFASACALARAFPLFTHRSG---ASRR-------------AEKRTVMVEFFLVGQD----NGPVEVSTLQCLTNATEGVRLAARIVDTPCNEMNTDIFLEEIIQVGKELGITPTIIRDEQLKTKGFGGIYGVGKAALHPPALAILSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQG-----------FKDNLHAVFCLAENAVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIIVDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLDCEVDAQEGDNMGRDSKRRRLV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NDH3-1", "uniprot_id": "PEPL1_HUMAN", "id": "Q8NDH3-1", "name": "Probable aminopeptidase NPEPL1", "aln": "--------------------------------------------------------------------------------------------------------------------MAN-----VGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTCLPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSG---ASRR-------------LEKKTVTVEFFLVGQD----NGPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQG-----------FKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDVEEGD-LGRDSKRRRLV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0C4FEI8-1", "uniprot_id": "GRSM_DROME", "id": "A0A0C4FEI8-1", "name": "Aminopeptidase grsm", "aln": "MAPYPNGFLSYAVAIHLKSPHLQMEESLRQGAGYWNALSSREKNQYRSKYQKRCLSKSSTSRHRRQSEKLKHMGCGRKKIVPKCSRKPTTPACKPRSVNRCPRKSSSNRSSRECMLMKSPKGMATDVKFNESLGCSDPQTHPVLIIGQLRHLNLLKFSHLESKLSPRVTEETFLNAVACLHPAPTDKVSLYLDVATVAALPLKASRHNTASRAHAITRLVKNHVLNVSEESVVLVCERENLFASACAVVRAFPLYSRKTGNLLASSQPKLNLGCGDGNANSGRNVVNVEFVLINKDGCIESEPLTDDELNCLNETTRAIRMTARIVDMPCNEMNVDHFIQEVEDVGRELCITPKVIRGEELLEQGFGGIYGVGKAAAVPPALVVLSHEPKGAQETIALVGKGIVYDTGGLSIKAKTGMPGMKRDCGGAAAILGTFYAAVQCG-----------FRDNLHAVFCLAENSVGPNATRPDDIHTLYSGRTVEINNTDAEGRLVLADGVCYANKDLKANIILDMATLTGAQGVATGKYHGAILTNSETWEAKSLQAGRKSGDLLAPIIYCPELHFSEFASAIADMKNSVADRQNAQSSCAGLFIAAHLGFDYPGIWMHVDMATPVHCGERATGYGVSLLLTLFGGHTDSKLLQSIASTDEEPPS---KRWCRD-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . ..::*: * * :***::*:*::***:**: : :**:..**.****** : *:: *:* ***. .***: ******* :.****:.* ** *****:. : :...:::***: ::******:.*****:::::* ** : :..* ***.*:.:* . *: . *:** ::* .:*::***** **.***.* *::*: .**:** * *.:**.*:* :************ ****.:*** *.** :*** ***************.** *************:**:* **:: * *:************:************ ****:*******************.** *** *:**:**********:******.*:**** *** .::**:*.***: *::**********:**:**********:*: *********:*:***:**:*:*:*:*:***.******:**:***:*** ::. **: ::. . * . ** ", "identical_positions": 316, "similar_positions": 132, "identity": "46.75%" }, { "cls_id": "homologset.agr.HGNC:16245", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A2F2-1", "uniprot_id": "D4A2F2_RAT", "id": "D4A2F2-1", "name": "", "aln": "MNRGHRHGVSSGCLG---TMEVKSKFGAEFRRFSLERSKPGK-FEEFYGLLQHVHKIPNVDVLVGYADIHG-DLLPINNDDNYHKAVSTANPLLRVFIQKKEEA-DYSAFGTDTLIRKKNVLSNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQAGASLEPEDQDSDEDDIIIEGSGEPQQIPKATPEALSLESLTQIELSFESGQNGFSPLQDTSLVAVPSSLDTESESRAPDQKLLEEDGTIITL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JK83-1", "uniprot_id": "PAR6B_MOUSE", "id": "Q9JK83-1", "name": "Partitioning defective 6 homolog beta", "aln": "MNRGHRHGASSGCLG---TMEVKSKFGAEFRRFSLERSKPGK-FEEFYGLLQHVHKIPNVDVLVGYADIHG-DLLPINNDDNYHKAVSTANPLLRIFIQKKEEA-DYSAFGTDTLIRKKNMLSNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSSQSTDNSLLGFPQQVEASFEPEDQDSDEDDIIIEDSGEPQQIPKATP-AQSLESLTQIELSFESGQNGFSPPQDTSLVPVPGSLDTELESRAPDQKLLEEDGTIITL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYG5-1", "uniprot_id": "PAR6B_HUMAN", "id": "Q9BYG5-1", "name": "Partitioning defective 6 homolog beta", "aln": "MNRSHRHGAGSGCLG---TMEVKSKFGAEFRRFSLERSKPGK-FEEFYGLLQHVHKIPNVDVLVGYADIHG-DLLPINNDDNYHKAVSTANPLLRIFIQKKEEA-DYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQKLLEEDGTIITL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "O97111-1", "uniprot_id": "O97111_DROME", "id": "O97111-1", "name": "", "aln": "MSKNKINTTSATAASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINNDDNFGRALKTARPLLRVIVQRKDDLNEYSGFGT---MKPRNLIGSILMGHTPVKTKAPSISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQR---TLTSTHRGS--FSRNSQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTG---------------VTLDESPTSTSAGNHNHQPP----LSSSPSSHHQQAASNASTIMASDVKDGVLHL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.:.: : ..: . . :******.*****:*::*.:. : *::* .*::::**:.*::.*: * * :. **********: :*:.**.****:::*:*:: :**.*** :: :*:: .:* .. *. **:*:*** **:******:********* *:*::**********:*****. **** **************:***********:*******:**:********:*** ******:***** . .* ** * :..* . .:: : .:: : :::* *:: .* :* : * .:*::.. * * . ..* . : :.*. : .. :: *", "identical_positions": 166, "similar_positions": 113, "identity": "43.92%" }, { "cls_id": "homologset.agr.HGNC:16247", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZUS5-1", "uniprot_id": "A0A8I5ZUS5_RAT", "id": "A0A8I5ZUS5-1", "name": "", "aln": "----MLLLHSSAHILHSALLLILLLELKGAD----MKELKVIQPQKLVSVYDGGSVILNCTVTSLTPVGPTRWFKGEGQNRQLIYSFRGDYFP-RITNIADVTKRNNTDFSIRISNIMLADAGTYYCVKFQKGTVEPDIEIQSGGGTELFVYGADMKKLKVVQPEKLISVDAGESVTLNCTVTSIIPMGPIKWFRGAQHSRHLIFNFTGGYFPRVTNVSDSSKRNNLDFSIRISNVMPADAGTYYCVKFQKELLETDIEIQSGGGTELLVFEPKTS-----------------GIAKILAAALLGYKLMLVIAVTLIHKHRCKIPE-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5JXA9-1", "uniprot_id": "SIRB2_HUMAN", "id": "Q5JXA9-1", "name": "Signal-regulatory protein beta-2", "aln": "MCSTMSAPTCLAHLPPCFLLLALVLVPSDASGQSSRNDWQVLQPEGPMLVAEGETLLLRCMVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPLNCDYSIYIHNVTREHTGTYHCVRFDGLSEHSEMKSDEGTSVLVKGAGDPEPDLWIIQPQELVLGTTGDTVFLNCTVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAVQAS----NNDFSILLQNVSSEDAGTYYCVKFQRK---PNRQYLSGQGTSLKVKAKSTSSKEAEFTSEPATEMSPTGLLVVFAPVVLGLKAITLAALLLALATSRRSPGQEDVKTTGPAGAMNTLAWSKGQE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . **: . *** *:* ..*. :: :*:**: : * :* :::*.* *.. . * :*.* . *::* **.*: . ** :. * .:: * *:** * *: .:***:**:*: : ..::: :.* .. : * .* ::**::*: :*::* ***** . * ***:**:** **. *:** * .*: * *. * * **** :.** . ***********:: .: : ** **.* * .** *: ::*..:** * : : *: * : * ", "identical_positions": 105, "similar_positions": 89, "identity": "30.09%" }, { "cls_id": "homologset.agr.HGNC:16249", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBM0-1", "uniprot_id": "D3ZBM0_RAT", "id": "D3ZBM0-1", "name": "", "aln": "----------MPLLYSIVGLAGLLLWMG----------------HTVGALRMPN-TTLVQGRPK----NIAVWPLSGLGVPRHRRKRHISARDMN--ALLDYHNHIR-------ASVHPPASNMEYMVWDEQLARAAEAWATQCIWAHGPSQ---LTKYVGQNLSVHSG--RYRSVVDLVKSWSEEKRHYSFPAPKDCTPHCPWLCSGPVCSHYTQMVWASSSRLGCAIHTCSSINVWGSTWQQAVYLVCNYAIKGNWIGEAPYKTGKPCSACPPSYQGNCNSNMCFSGLKS----NRLPWV---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A5I3-1", "uniprot_id": "CRSPL_MOUSE", "id": "A2A5I3-1", "name": "Peptidase inhibitor R3HDML", "aln": "----------MPLLSSIVGLTGLLLWMG----------------HTVGALRMPN-TTLVQGRPK----NTAVWPLSGLGVPRHRRKRHISARDMS--ALLDYHNHIR-------ASVHPPAANMEYMVWDEQLARSAEAWATQCIWTHGPSQ---LMKYVGQNLSIHSG--RFRSVVDLVRSWSEEKRHYSFPAPKDCTPHCPWLCSGPVCSHYTQMVWASSSRLGCAINTCSSINVWGNTWQQAVYLVCNYAIKGNWIGEAPYKAGKPCSACPPSYQGNCNSNMCFSGLKS----NRLPWV---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3Y0-1", "uniprot_id": "CRSPL_HUMAN", "id": "Q9H3Y0-1", "name": "Peptidase inhibitor R3HDML", "aln": "----------MPLLPSTVGLAGLLFWAG----------------QAVNALIMPN-ATPAPAQPE----STAMRLLSGLEVPRYRRKRHISVRDMN--ALLDYHNHIR-------ASVYPPAANMEYMVWDKRLARAAEAWATQCIWAHGPSQ---LMRYVGQNLSIHSG--QYRSVVDLMKSWSEEKWHYLFPAPRDCNPHCPWRCDGPTCSHYTQMVWASSNRLGCAIHTCSSISVWGNTWHRAAYLVCNYAIKGNWIGESPYKMGKPCSSCPPSYQGSCNSNMCFKGLKS----NKFTWF---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7EZY0-1", "uniprot_id": "E7EZY0_DANRE", "id": "E7EZY0-1", "name": "", "aln": "----------MNLVCAQLVFAVTLWTAG----------------AEAGIVAVCSGTSLLQAEQLSM--EAEVRNSSDGSTFRVRRRRFISGKDMT--ALLDYHNRVR-------SQVFPPAANMEYMVWDERLAKSAEFWASQCIWEHGPHH---FLQHIGQNLSIISG--RYKSIIDLVKSWYDERHSFSYPS----------RCSGSVCTHYTQMVWAASNKIGCAIKKCSDIFVFGSMWKQATLLVCNYAIKGNWVGEAPYKIGRPCSACPSSYGGSCNKNQCDSRPKSRRNTNGFRGYKQ-------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VY39-1", "uniprot_id": "Q9VY39_DROME", "id": "Q9VY39-1", "name": "Venom allergen-1", "aln": "MPRLLSKCSVFALWAPAVLLFVLACEKGLAGAQTLIETITTTTPASSGGYCAAALCELYNGTHLVHVPHTACGNNGSFSPACGPEPKLLEMSERRRQLLLDMHNLARSKIASGNLDGYRSAAHMPLLRWDTELEQMAALHAKRCQFAHDKCRNTPRFKFSGQNIGYFWIGREFKSHSRRMKSFVINWFREHQDANQSFIDRYHPHPQGKKIGHFTLLVSDRVNRVGCAGVR----FLEPKSNRFQFMLTCNYDYN-NIFNEPIYQSGPAGSKCPQHRISEKFPSLCDWRDAN----NDLDSEESDEDGNTLDNNIPL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IRL3-1", "uniprot_id": "Q8IRL3_DROME", "id": "Q8IRL3-1", "name": "Venom allergen-1", "aln": "--MSRSPCWIFLLYLVLIIFTFTFAQN----------------------YCDPELCPSGR--------HVACQNSGRFVSGCSGEFVQVDAHIP---LILQLHNERRNLIAGGGVSGFPSAVQMATMSWDTTLAQLAAYNALQCRMAHDECRNTNTYRYAGQNLSILFTRSVDVAVFLRQR--IAAWFDENRDATSGDMEDYQMR-GGPAIGHFTTMVNERNNRVGCAIAR----FTDAN-NVQATLLACNYAVT-NVVNNPVYRAGTAASECTTGRNSN-YPNLCSPNEVY----NYNQWSG--------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : : . . :. :*: ** * . . .* :* : ** * : * * :* *. : :. ***:. : : : * *:* :* .::*** . *.*** . * ..:. *: * . * *. .. . * * ", "identical_positions": 35, "similar_positions": 43, "identity": "11.04%" }, { "cls_id": "homologset.agr.HGNC:1625", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LF54-1", "uniprot_id": "A0ABK0LF54_RAT", "id": "A0ABK0LF54-1", "name": "", "aln": "-------------------MLWLTPDALSIPASWVQMESSTVFD--YDKSNLLCDN-NVIFFSIIFTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNVFILNLCLSDLMFSCLLPVLIS-AQWGWFLGDFFCKFINMIFCISLYSSIFFLTIMTIHRYMSVVSPIS--SLGIYTLRCRMLVTTSVWAASILFSIPDTVFHKVISLK-------------CDFSE--RHGLLASVYQHNILFLLSMGIILFCYVQILRTLFRS--RSRQRHRTVRLIFTIVVAYFLSWAPYNLVLFLKT---EVIQLS--CEGRQQLDFAMIICRNLAFSHCCFNPVLYVFVGVKFRRHLKRLLQQVWLCPKTS-NPVPFSYSPGTFTYEGPSFY-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0M1-1", "uniprot_id": "XCR1_MOUSE", "id": "Q9R0M1-1", "name": "Chemokine XC receptor 1", "aln": "------------------------------------MESSTAFYDYHDKLSLLCEN-NVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLIS-AQWSWFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPIS--TLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVISLN-------------CKYSE--HHGFLASVYQHNIFFLLSMGIILFCYVQILRTLFRT--RSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKT---GIIQQS--CESLQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTS-STVPCS--PGTFTYEGPSFY-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P46094-1", "uniprot_id": "XCR1_HUMAN", "id": "P46094-1", "name": "Chemokine XC receptor 1", "aln": "------------------------------MESSGNPESTTFFY--YDLQSQPCEN-QAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWGWVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLS--TLRVPTLRCRVLVTMAVWVASILSSILDTIFHKVLSSG-------------CDYSE--LTWYLTSVYQHNLFFLLSLGIILFCYVEILRTLFRS--RSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQIIRS--CEAKQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASIPHSPGAFAYEGASFY-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13AAP3-1", "uniprot_id": "A0AB13AAP3_DANRE", "id": "A0AB13AAP3-1", "name": "", "aln": "---------------------------MTLN--------NTTYDYDDDYEDQLCRKDDVVKFGSIIIPLFFSIVVVMSCIGNVLVLIILALYESLKFLTNVFILNLALSDLLFTFGLPFWASYFIHGWTFGEIGCKAVKFLFYVGFYSSVLFLTLMTIQRYMAVVHPLS----DWEKCRCFSVAPIIIWMMSGTAALVGAHYSKILKDLNNTY---------CEYES--IKVKSGIAYFQNAFFFAAFLIMGFCYCRMLQTITNA--RTSKRHKTVRLIFSIALVFFIGWAPYNIAMFLRSLTDQNIPPFTICEVSKGVDYAYYLCRLLAFSHCCLNPVFYVFVGVKFRNHLYMILEKILKKKKKL--DSSQGRMAK-NQSQG-SMY-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32T4R5-1", "uniprot_id": "A0AB32T4R5_DANRE", "id": "A0AB32T4R5-1", "name": "", "aln": "---------------------------MDLQTVTPKQNENSTYDYNDDYPDEACNKMNVIQFGTIVSPIIFTIVVMFSCVGNILVLCVLVKYENLRSLTNTFLLNLAISDLIFTVGLPFWAYYYVNGWTLGDHACKAVNYVFYTGYYSSIIFMTVLTIHRYVAVVHPLSV-VMSRKSIHCYATS-IVVWIISLSAAIPQAMFKTVVRNPIDTQSEASDVIKLCDFDGQ-IHWKLWSTYLQNGFFIVAFLIIAFCYTVILTRLLRP--TSHTRKKTVHLIFFIVLFFFLGWGPFNVAIFLDSLISWGISPFNECEVSKSIDYLMYVSQMVAYSHCCLNPVVYVFMGIKFRNHLKKMLWTLCKNNVEP--PNRNSRIIYSNGEEI-SMY-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1REM0-1", "uniprot_id": "A0A8M1REM0_DANRE", "id": "A0A8M1REM0-1", "name": "", "aln": "MISSFLSDGQRRFLKEQFTTPNECTDDMMHEDMSYEVFNFSYDDYYLTYEYPLIVLEEGNSLFGKISAICYSLIVCMGLPGNLFLLWLVLKKVGLSSSADCLLLHLTISDLVFTLTLIPWTIYHIRGWIFGFAACRLFSWFIFLGLYSYMLFLTVMTVHRYIAVQHPVFASSVGNRGRLYAHVSSAVVWMISLGFSLPEMIFSETLDRYDG--------VQCVSYSRSEFWILFGYFSQIILFFLLPFLVIALCYARMGFTIHQSRIRSRNRHHAVCLILSIAIGFFICWAPYNIFLFIHSLEFLGVVELR----ETLSDTVYCVTHILAYFHCCLNPLVHIFGGKKYRNFLPWSRRVRWLPQSFS------NEMFSSQSSFSGQFHL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : : ::. :. ** ::* :: .* :: ::*:* :***:*: * .* :* *: .. .: . ** ::*:*::*::**::* *: :* * :: : : .:. :*: .: :: :** : : .. : *:::* **: :.: :*: *.*:*. :*: : : : : : :*: ***:**:.::* * *:* .* .:: ", "identical_positions": 48, "similar_positions": 92, "identity": "12.37%" }, { "cls_id": "homologset.agr.HGNC:16252", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2KBB4-1", "uniprot_id": "A0A0G2KBB4_RAT", "id": "A0A0G2KBB4-1", "name": "", "aln": "MPR-TRNTGDLCPISEDTTHSGRSRRSAQRS-YINRMAEATPANMNDPLLLPLRINPPGLSLAQFILGYMSWLTYLACFLRTQAQQVLLNTCRFKLLFQKLIEKMGLLVLCVFGFWMFSMHLPSKMEVWQDDSISGPLQSLRMYQEKVRHHTGEIQDLRGSMNLLIAKLQQMEAMSDEQKMTQKIMKMIQGDFIEKPDFALKSIGASIDFEHTSPTYNHDKARSYWNWIRLWNYAQPPDVILEPSVTPGNCWAFAGDRGQVTIRLAQKVYLSNVTLQHIPKTISLSGCLDTAPKDFVIYGMEHPPREEVFLGAFQFQPENIIQTFQLQNQPPRGFAAVKVKISSNWGNPRFTCLYRVRVHGCATPPKR-SYL-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DA32-1", "uniprot_id": "SUN5_MOUSE", "id": "Q9DA32-1", "name": "SUN domain-containing protein 5", "aln": "MPR-TRNIGALCTLPEDTTHSGRPRRGVQRS-YISRMAEPAPANMNDPLLLPLRMNTPGLSLVQILLGYMSWLTYLACFLRTQTQQVFLNTCRCKLFCQKVMEKMGLLVLCVFGFWMFSMHLPSKVEVWQDDSINGPLQSLRMYQEKVRHHTGEIQDLRGSMNQLIAKLQKMEAISDEQKMAQKIMKMIQGDYIEKPDFALKSIGASIDFEHTSATYNHDKARSYWNWIRLWNYAQPPDVILEPNVTPGNCWAFASDRGQVTIRLAQKVYLSNITLQHIPKTISLSGSPDTAPKDIVIYGLESLPREEVFLGAFQFQPENVIQMFQLQNLPPRSFAAVKVKISSNWGNPRFTCMYRVRVHGSVTPPKD-SHLEPLS---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TC36-1", "uniprot_id": "SUN5_HUMAN", "id": "Q8TC36-1", "name": "SUN domain-containing protein 5", "aln": "MPRSSRSPGDPGALLEDVAHNPRPRRIAQRGRNTSRMAEDTSPNMNDNILLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCRCKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSGEIQDLRGSMNQLIAKLQEMEAMSDEQKMAQKIMKMIHGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHSYWNWIQLWNYAQPPDVILEPNVTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGMEGSPKEEVFLGAFQFQPENIIQMFPLQNQPARAFSAVKVKISSNWGNPGFTCLYRVRVHGSVAPPREQPHQNPYPKRD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VKG2-1", "uniprot_id": "Q9VKG2_DROME", "id": "Q9VKG2-1", "name": "", "aln": "------------------------------------MAHNSRNNLG---IMRLRED----------------VDDISHILRQQQIDSKVAQGSCKFNCLGGEPKG------------------VGSGMCNNRDVSAYVDT--LFKRKIGHLMDDVYNLKKQVMSADCSSKSAQSTPKPESVALAKPRIN---------YASEELGARIINVKAHSIDGTNIIR---SLLGLDFSTNPPVNMIRTGLSPGSCFGFNGSRATVTLHLARTIIVEAITLTHVAREMTPDLCVKSAPKNFDVYGLRSENSKRELLGQWSYDNAANKRTQSYSVRSDTFFRNLDFSFNSNHG-ANSTCIYRVEVYGRL----------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **. : *:. :: :* : . :: ** * : . *: * : :: .:.. ::: :::.*: * .:: :*: .: .. :. :: .. :.:: :: :* :.:** * :: . : : . : * ::** ::...::**.*:.* ..*. **::**:.: :. :** *:.: :: . . .:***:: :**:. :. :** :.:: : . . * :...:.** * . **:***.*:* ", "identical_positions": 49, "similar_positions": 118, "identity": "12.93%" }, { "cls_id": "homologset.agr.HGNC:16253", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A9V0-1", "uniprot_id": "D4A9V0_RAT", "id": "D4A9V0-1", "name": "serine C-palmitoyltransferase", "aln": "MANPRDS---------AVTNG-------------------------------TLRNPKTQPGKRQSTD------------CVKNGISK-------EAQQNRKAEEDDKLVFKP-YPEPPLYVFVFTYMGYGIGMLFGYLRDFMRNWGIEKCNAAVEREEQKDFVPLYQDFENFYTRNLYMRIRDSWSHTVCSVPVPNFDIMEKVTDDYNWTFRHTGKVIKNVINMASYNYLGLASKYNESMEKVKDTIEKYGVGVASTRNEMGSLDIHNELEDLMAKFLNVEAVMVFGMGFATNSTNIPIFVGKGCLILSDEFNHTSVILGSRLSGAVIRPFKHNNIQNLEKLLREAIIRGQPRTG-RAWKKILILVEGVYSMEGSIVNLPQIVALKKKYKAYLYMDEAHSIGCTGTMGQGIRELFGLAPEDIDIYMGTFTKSFAASGGYIAGKKEIVDYVRVQSHSATYATSMSPVVAAQIIRSLKIMMGYEGNFGGVQRIQQLRENIKYFRRRLIEMGFIIYGNDYSPVVPVLLYMPAKVSAFGRLLLKKKIAVVVVGFPATSLPEGRARFSLSSAHTREMLDTVLEVVDKIGDLLNVKYFPYKK--SGRAVLYNKENFDNEASFEEKSSEPEA-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BG54-1", "uniprot_id": "SPTC3_MOUSE", "id": "Q8BG54-1", "name": "Serine palmitoyltransferase 3", "aln": "MANLNDS---------AVTNG-------------------------------TLHNPKTQQGKRQSTG------------CVKNGISK-------EAQQNRKAYAEDKPVFEP-YQEAPLYVYVLTYMGYGIGILFGYLRDFMRNWGIEKCNAAVEREEQKDFVPLYQDFENFYKRNLYMRIRDSWSHTVCSAPEPYMNVMEKVTDDYNWTFRHTGKVIENIINMASYNYLGLAGKYDDSMVRVKDTLEKYGVGVASTRNEMGTLDIHKELEDLMAEFLNVEAVMSFGMGFATNAMNIPVFVGKGCLILSDEFNHTSVILGSRLSGAVIRPFKHNNAENLEKLLREAIIRGQPGTG-RAWKKILIVVEGVYSMEGSIVNLAQIVALKKKYKAYLYIDEAHSIGCTGPTGRGVRELFGLDPEDIDVYMGTFTKSFSGSGGYIGGKKEIVDYLRMQSHSTTYATSMSPVVAAQLIRSLKITMGYEGNIGGMERIQQLKENIKYFRRRLKEMGFIIYGNDFSPVIPVLLYMPAKVSAFSRFLLKKKISVVVVGFPATSLPEGRARFSMSSAHTREMLDTVLEVVDELGDLLNVKYFPLKK--SGRAILYNKEGFDNEASFEEMHSEPEA-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NUV7-1", "uniprot_id": "SPTC3_HUMAN", "id": "Q9NUV7-1", "name": "Serine palmitoyltransferase 3", "aln": "MANPGGG---------AVCNG-------------------------------KLHNHKKQSNGSQSRN------------CTKNGIVK-------EAQQNGKPHFYDKLIVES-FEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTR-RAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKK--SARPELYDETSFELED------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q9N3-1", "uniprot_id": "A0A8M9Q9N3_DANRE", "id": "A0A8M9Q9N3-1", "name": "serine C-palmitoyltransferase", "aln": "MIRTEEL---------HSCNG-------------------------------TLKSRSGQ--KQTENY------------TLKNGYHKNE-----KVQKNGNGFHQPRVRGEDSFEEAPMYVAVLTYMGYGIVILFGYFRDFLRAVGLEKCHQAQEREEQKDFVPLYQDFENFYKRNLYMRVRDNWNRPICSLPGPVFDLMERVSDDYNWTFRLTGRTIENVINMGSYNYLGFAENNVDFLKTVAEKTRQYGVGVCSTRQELGNFSIHEELEHLVADFLGVESAMAFGMGFATNSMNIPALVGKGCLILSDELNHTSLILGARLSGATIRVFKHNNMQSLEKLLKEAICSGQPRTH-RSWKKILIMVEGIYSMEGSLVRLPEIIALKKKYKAYLYLDEAHSIGAVGPTGRGVTEHFGVDPKEIDVLMGTFTKSFGATGGYIAGKKELVDYLRCHSHSAVYATAMSPPVVEQIIRAIKCIMGVDGTTEGQRRVRQLAENTHYFRSRLKEMGFIIYGNKDSPVIPLLLYQPGKVGAFSRAMLKRKIGVVVVGFPATTITEARARFCVSAAHTRDMLNKVLQSLDELGDYIRVKFSRHRR--PYRPELYNVTNFGLDS------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V3F2-1", "uniprot_id": "Q9V3F2_DROME", "id": "Q9V3F2-1", "name": "serine C-palmitoyltransferase", "aln": "MGNFDGDSGTVFEQSYATTNGNGKVPNGNGAADLSAPEKQELLRKFSAPAYTEIRTRRCQPKPANDAQSPSSINYHPEKKSIPNGHASILDQESKPNQAEGKLSPELEHFQKTSFEEVPLHTACLTYLGFYLLMILGYINQLLFVP-----KVATEK-GRDGYVALYDAFESFYSRYVYRRIKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETR-CLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHEDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAIDEIADDLGLKYSRKPR--DPNPVIY---------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40970-1", "uniprot_id": "LCB2_YEAST", "id": "P40970-1", "name": "Serine palmitoyltransferase 2", "aln": "MSTPANYTRVP------------------------------------------LCEPEELPDDIQKEN--------------EYGTLDS------PGHLYQVKSRHGKPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLGMTFQK--NKHLDLLEHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSG-AVYPCMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTN-RPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDKYFVN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : . * . : . : * : :**:.: : ::*:..::: : : :.. .. :. **.** * : *: * :.:. . * : ::::.: . * :* :*:.***:**:* : : . ..* ::* . : * * * ::. * .: *.**:.**: : ::. .*::*** **:*: * *****. : ***.: .**::::: : *:* . :.*.*::* .**::****:: .*.::: ******.**::*****:*. *. *:*: : *.: *.::*: ********..:***:.. : ::* :* . : *: ::.. : * : ::: * * .::::: * :*:* * .:*.* ** :.*:*:*:* .*: *. * : ::*..* ..:***.: *.* **.:*:: *:: :: *. :.::.* : :* . : ", "identical_positions": 130, "similar_positions": 191, "identity": "20.73%" }, { "cls_id": "homologset.agr.HGNC:16254", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80ZW0-1", "uniprot_id": "STK35_MOUSE", "id": "Q80ZW0-1", "name": "Serine/threonine-protein kinase 35", "aln": "-----------------------------------------------------------------MGHQESPLTRAAAGGAAYIKRLRKVLSWRELGDGHGNLEAEASPGSVAVITRAAPRRATRSARLPASRPTRLCRQARLGTDHPPARAPRGNRFARKRNSAGQITIQGPAPPHLGARRRDEARGARAAPLLLPPPPAAMETGKENGARRGTKSPERKRRSPVQRVLCEKLRP--AAQAMDPAGAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQVTCAA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZKU3-1", "uniprot_id": "D3ZKU3_RAT", "id": "D3ZKU3-1", "name": "Serine/threonine-protein kinase 35", "aln": "MQVKSGKALAERTRLAKALCTNRGILARSFCWLGVLASDWFRAVAAAGSTSAVERRRSSSLASWGMGHQESPLTKVAAGGAAYIKRLRKVLSWRELEDSHGNLEAEASPGSAAVISGAAPRPATRPTRLPASRPTRLCRQPGLGTDHPPARAPRGNRSARKRNSAGQITIQGTAPPHLRARRRDEAGGARAAPLLLPPPPAAMETGKENGARRRTKSPERKRRSPVQRVLCEKLRP--VAEAKDPAMAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGAKVAVKKIRCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKDVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQVTCAA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TDR2-1", "uniprot_id": "STK35_HUMAN", "id": "Q8TDR2-1", "name": "Serine/threonine-protein kinase 35", "aln": "-----------------------------------------------------------------MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSA----TRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKD-GARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGG--SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ********::..******:*** * ***** :.**.* *:***.*.*. :* ** :* .:**.:* **. *:*** * ** *:* *** ..***:****.***: * ***** ********************: **** *:********** *. . **** .*.* **. **.***********:**** .*****************************:*********************************:**********************.********************************:**************************************************************************************:*************************************************************************************************:********************************", "identical_positions": 461, "similar_positions": 42, "identity": "76.07%" }, { "cls_id": "homologset.agr.HGNC:16255", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O95932-1", "uniprot_id": "TGM3L_HUMAN", "id": "O95932-1", "name": "Protein-glutamine gamma-glutamyltransferase 6", "aln": "-----------------------------------------------MAGIRVT-------KVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSR---ALDCEEILIFTMETGPRASEALHTKAVFQTSE----LERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLG--EFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPS----YNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHE-DESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKP-SIAGKFKVLEPPMLGHDLRLALCLANL-TSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEK--LLVEKDITLED-FITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1M4T7-1", "uniprot_id": "F1M4T7_RAT", "id": "F1M4T7-1", "name": "Protein-glutamine gamma-glutamyltransferase E", "aln": "-----------------------------------------------MAGVRIT-------KVDWQHSENGAAHHTQDYPCPELVVRRGQLFSLTLDLNR---ALDSEEALIFTVETGPHASEALHTKAIFQTAE----LEIGDTWTAAKEEQTENTITVSLSSPSNAVIGRYLLSARAASRRKHSDRKLG--QFILLFNPWCPEDDVFLDSEEERQEYVLNDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPSHQDDPATDVSHRHDPVYVTRIISAMVNSNNDRGVVQGQWQGKYGGGTNPLNWRGSVAILQKWFKGKYKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDGNLSVDKYVDSYGRTLEDLTEDSMWNFHVWNESWFARQDLGSS----YDGWQVLDATPQEESEGTFQCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHE-DKRRERVYSDTKKIGRCISTKAVGSDSRVDITGLYKYPEGSRKERQVYGKALKKLLSVEAWGRRRRIRRASVRGIWRDDLLEPVTKP-SITGKFKVLEPPVLGQDLKLALCLTNL-TTRAQRVRVNVSGATILYTRKPVAEILRESHTMKLGPLEEKRIPVTISYSQYKEDLTEDKKILLAAMCLVSKGEK--LLVEKDITLED-FITIKVLGPAVVGVTVAVEVLVINPLSESVKDCVLMVEGSGLLQGQLSVEVPSLKPQERALIQFNITPSKSGPRQLQVDLVSSQFPDIKGFVIIHVATAK------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M3BAQ1-1", "uniprot_id": "A0A8M3BAQ1_DANRE", "id": "A0A8M3BAQ1-1", "name": "Protein-glutamine gamma-glutamyltransferase 2", "aln": "-----------------------------------------------MCSSSSSNTPDQGVRVDLECVKNNTDHHTHEITQERLIIRRGQAFSLKISAEN---IQQN--HISITAETGPGASEVKHTLFSFSTQS----STN----PAQVCSRSESSVSLALVFPSDAPVGRYSVCVKHGS-----SSCMN--TLTLLFNPWCKDDHVYLPSEAERQEYIMSEQGVLYKGVDEYITSMNWDYGQFEEDIVDICLKLLDLNPKCLKDPQEDYSARCNPVYVSRVVSAMINCNDDQGVLAGQWGDSYTGGVPPSRWSSSVEILRRWVKYNCSPVKYGQCWVFAAVMCTVLRCLGIPCRVVTNYQSAHDTDRNLVVDEYFSDYG-VRPKNSQDSVWNFHVWVEAWMRRPDLTEDTL--YDGWQVLDPTPQEKSSGTYCCGPAPVMAILEGHTEVKYDVPFVFAEVNADRVCWLLMT-DGSRKKIMSDSRSVGQNLSTKAVGSSSRLDITDLYKHGEGSAQERAVYTEAVHRLT----------------------DLQIPESPPVSVQMRLSLDVPPLNGADVPLKLFLK---GSRTQCVCVNISAQVMRYTGAPAAAVWSHSTDVQLQDTEEKALSFTLPYSAYGHRMLENNCIKVSAIAREKNNPKDTYLTEKNIILHTPNLSITVSGSPLLDSEMTATVQFENPLSSTLQNCSISLSGSGLLKSTEKSSTVQLGPGQRIRLQVSFTPYRLGLKKLMATFNSATFKDVQASVDVDVRSA-------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLU2-1", "uniprot_id": "Q9VLU2_DROME", "id": "Q9VLU2-1", "name": "protein-glutamine gamma-glutamyltransferase", "aln": "MGQKLSCCQKCGDWKWCTSKDNEESTLRIRNANANYFTGIPQGDKTDGASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLECSLKVLGTVG------RIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSR-------------------HAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIEQP-LKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIEPRPEDLLQPNGSHRSSNIIRRRTDVIA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. :: : .: : *. . *::***: * *.: .. . : :* .. .* * : . . * : .:::: : *. . : .: : : :****** :*.*:* .. :*:**:: : ::::* : : . *. ****..::: .*.:*. : * :*: *:* :**::*. :* **: *:* .: **. * .* .** **::: * . . **:.*** *:.*: *: *.***. *::: :.*****: .* ** :.. . : **:**:*** * *: * ** . ::****:*.**** *.. : ***.* *: :*. .* ********* : * . : : .:: :*: :***** . .* ***. **: * * :** . :*::: . .: :.: * .. : * : :*:: . ::* .: ** .. : . :.* ... : . : :. * . : .: : ::* . .. :. . .. : : . : . *** ::. : :.*.*: : . . : .. ** * : . : * : *:.. .: . ", "identical_positions": 149, "similar_positions": 221, "identity": "18.56%" }, { "cls_id": "homologset.agr.HGNC:16257", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AQ07-1", "uniprot_id": "TBB1_MOUSE", "id": "A2AQ07-1", "name": "Tubulin beta-1 chain", "aln": "MREIVHIQIGQCGNQIGAKFWEVIGEEHGIDCAGSYCGTSALQLERISVYYNEAYGKKYVPRAVLVDLEPGTMDSIRSSRLGVLFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVMDVVRRESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRILNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENTDACFCIDNEALYDICFRTLRLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNIMAACDPRRGRYLTVACIFRGKMSTKEVDQQLLSIQTRNSNCFVEWIPNNVKVAVCDIPPRGLNMAATFLGNNTAIQELFTRVSEHFSAMFRRRAFVHWYTSEGMDISEFGEAESDIHDLVSEYQQFQDVRAGLEDSEED-VEEAEVEAEDKDH--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M0R8B6-1", "uniprot_id": "M0R8B6_RAT", "id": "M0R8B6-1", "name": "Tubulin beta chain", "aln": "MREIVHIQIGQCGNQIGAKFWEVIGEEHGIDCAGSYCGTSALQLERISVYYNEAYGKKYVPRAVLVDLEPGTMDSIRSSRLGILFQPDSFVHGNSGAGNNWAKGHYTEGAELIETVMDVVRRESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRILNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENTDACFCIDNEALYDICFRTLRLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNIMAACDPRRGRYLTVACIFRGKMSTKEVDQQLLSIQTRNSNCFVEWIPNNVKVAVCDIPPRGLNMAATFLGNNTAIQELFTRVSEHFSAMFRRRAFVHWYTSEGMDISEFGEAEADILDLVSEYQQFQDVRAGLEDIEEGGEEEAEMGAEDKNH--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H4B7-1", "uniprot_id": "TBB1_HUMAN", "id": "Q9H4B7-1", "name": "Tubulin beta-1 chain", "aln": "MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEE-DEEVTEEAEMEPEDKGH--------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FC32-1", "uniprot_id": "E7FC32_DANRE", "id": "E7FC32-1", "name": "Tubulin beta chain", "aln": "MREIVHLQIGQCGNQIGSKFWEVISDEHGINRVGAYEGDMDLQLERVNVYFNEAHGGKYVPRALLVDLEPGTMDSVRGSQIGQLFRPDNFIHGNSGAGNNWAKGHYTEGAELVEQVVDRVRNEAESCDCMQGFQFVHSLGGGTGSGMGTLIINKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNATLSIHQLIENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDPRNMMTACDPRRGRYLTVAGIFRGRMSTKEVDEQMLAIQQKNSNYFVDWIPHNVKVAVCDIPPRGLKMASTFIGNNTAIQEVFKRIGEQFALMFRRKAFLHWYTGEGMDELEFSEAESNLNDLVSEYQQYQDATADMDYEEEEVMEEESSIAHSTQVEIKTEVVTETSVSE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P02557-1", "uniprot_id": "TBB_YEAST", "id": "P02557-1", "name": "Tubulin beta chain", "aln": "MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQKERLNVYFNEASSGKWVPRSINVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVLPSPKTSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICQRTLKLNQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTAIGSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSVKEVEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAPQGLDMAATFIANSTSIQELFKRVGDQFSAMFKRKAFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEATVEDDEEVDENGDFGAPQNQDEPITENFE---------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****:*:. ********: *** * ***:: *: * :* **:.**:*** . *:***:: *******:*::*.* :* **:**.::.*:*.*** ************:: *:: :*.*:*.**.:****:.**************::.*****:***:: :***:****.**********.**:***:*::* :*********** ***:*. *:*****:*** .***:*****:*****:********:********** *:***** ***.:*:*:*.********.:* *:*.* *.******* :***::*.***:::: :* :**. **:***:**:.***.:.*:**.**:**:.*.*:***:*.*:.::*: **:*:**:****.**** **.*** :: ********:*:. . : : : .. ", "identical_positions": 271, "similar_positions": 122, "identity": "58.15%" }, { "cls_id": "homologset.agr.HGNC:16258", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6GMV2-1", "uniprot_id": "SMYD5_HUMAN", "id": "Q6GMV2-1", "name": "Protein-lysine N-trimethyltransferase SMYD5", "aln": "-------------------MAASMCDVFSFCVGVAGRARVSVEVRFVSSAKGKGLFATQLIRKGETIFVERPLVAAQF--LWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLP--HPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHYPPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKG----QLELLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIG-TSSLSQWVHACDTLELKPQDREQLDAFIDQL----------------------YKDIEAATGEF-LNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADEPN------------------VTSEEEEEEEEEEEGEPEDAELGDEMTDV------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZII8-1", "uniprot_id": "D3ZII8_RAT", "id": "D3ZII8-1", "name": "Protein-lysine N-trimethyltransferase SMYD5", "aln": "-------------------MAASMCDVFSFCVGVAGGARGSVEVRFVSSAKGKGLFATQLIRKGETIFIERPLVASQF--LWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLP--HPELCSVRKDLHQNCPRCQVTYCSAECRLAAAEQYHQILCPGPSQDDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFSHFCSKTANEEEEIVHKLLGDKFKG----QLELLRRLFTEALYEETLSQWFTPDGFRSLFALVGTNGQGIG-TSSLSQWVHACDALELKPQEREQLDTFIDQL----------------------YKDIEAATGEF-LNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIEPGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADDPN------------------VTSEEEEEEDEEE-GEPEDAELGDEMTDV------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TYX3-1", "uniprot_id": "SMYD5_MOUSE", "id": "Q3TYX3-1", "name": "Protein-lysine N-trimethyltransferase SMYD5", "aln": "-------------------MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQF--LWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILP--HPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPS-HDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKD----QLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIG-TSSLSQWVHACDALELTPQDREQLDTFIDQL----------------------YKDIEAATGEF-LNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPN------------------VTSEEEEEEDEEE-GEPEDAELGDEMTDV------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1RET2-1", "uniprot_id": "SMYD5_DANRE", "id": "F1RET2-1", "name": "Protein-lysine N-trimethyltransferase SMYD5", "aln": "-------------------MAAPVDDMFSRCVDSA-KASNCVDVRFINNVKGKGLFAKKPFKKGDTIFIERPLVSSQF--LWNALYKYRACEYCLRALETAEENARRLSGLPALILP--HPELCKVRPDRHQACPQCQVMYCSSECRQAAMDQYHKILCLGPSNDDPDHPVNKLQDAWRSVHFPPETSSVMILAKMVATIKQTQDKERWQRLFTNFCSRTANEEEEIVHKLLGEKFQG----QLGLLRNLFTTALYEDRLSQWFTPEGFRSLFSLVGTNGQGIG-TSSLSQWVHACDALELPRQQREQLDAFIDQL----------------------YKDIDKETGDF-LNCEGSGLFLLQSSCNHSCVPNAEASFPENNFLLHLTALGDIGPGEEICISYLDCCQRDRSRHSRHKILRENYLFICSCQKCLSQMDDAD------------------MTSEDEEEVEGEG--ETEGEDMEDEMTDV------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VDD0-1", "uniprot_id": "Q9VDD0_DROME", "id": "Q9VDD0-1", "name": "Protein-lysine N-trimethyltransferase SMYD5", "aln": "--------------------------------------MNNFEIRELP-GKGRAMIATKNFAKDEVIFEEEPFVSRQF--SWNVAYGYAACDHCMRPLETVLENVRRLASDPKVEVPLLQHDPTAQWVAQFTQCPRCKVRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPINVLNETWKKMHYPPETGSIMLIVRLMALYQQSTKKEEFLEQLQSFQSLIVNREQKIYHKMLGENFEQ----QMEQLYLAFCNAFTGEEFSIFKTPDAFKTLMAILGTNSQGIA-TSVLSQWVAKVSDLPLTDSEKEQLDTVIDGL----------------------YAKVGEFAGEF-LNNEGSGLYLLQSKINHSCVPNACSTFPYSNDIVVLKALAPIQQGEEICISYLDECMLERSRHSRHKVLRENYVFICQCPKCRAQASDPD------------------ETSEDDDDDDEMD-----DYDDDDDMN--------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38890-1", "uniprot_id": "SET5_YEAST", "id": "P38890-1", "name": "Histone-lysine N-methyltransferase SET5", "aln": "MTLTIKIGTLNDSDQSAVHNGTENGSDFRKITPTEEEICDDVVLLWKEEPGTEDATIQHLYDRITERNQSWKLSASRFRKILNEHHLYDTDLETVSLYKDKIHFPKALDSDAKVEVKFIDDEHGRGLFAKRDFSKGQIILKENKPIVYIPPLDKLFLISNGKACARCGKALYDLTQHKIMVHYLDCEVCKAIWCSEKCKKAHASLHELLYHSWRSNRIDILHAGNWKRFVNYCEKYCFTAAFSVGLIYGSMLLDTTGEVKEQWQKLASISQRERIKLRDASGIGSTFSLLNGTTVHTEEESDNGTKKGVEKNIDDETVWEKCYELFCGAFPKASEEIDFEKFLTMIGTFNINQYNGQVYHWISFINHDCEPNAYIEQVEEHEELRLHARKPIKKGEQIRITYVNPLHGVR---LRRRELRVNWGFLCQCDRCQNELSTFERVPNLEKKNADANLGVEKIDSNDSSEDGSKKSTGNRKSSMREAQPDLKEILKNGKEFELDIPETVDTQGNVRKTSVRFDSNVSVAVDER", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . : : . : : :* * : * : : : . : * . . : . : . : . . : . * :.: * : :*: . : . :: :: . : : . :: .: : : : . : . .: : :..**. * * : . :: :: ** : .. * * :* .. :: * **.* *** .: : : * * **:* *:*:: * *:: ** *: * *.* :* : . : *::..: . : ", "identical_positions": 40, "similar_positions": 98, "identity": "7.56%" }, { "cls_id": "homologset.agr.HGNC:16259", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M3B2-1", "uniprot_id": "F1M3B2_RAT", "id": "F1M3B2-1", "name": "", "aln": "MGDTAPPQAPAGGLGGASGAGLLG--------GGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTMQLLSLVQHGQGARKASKHAKATATTATTTAPPPPPTAPPVASQAAST-APPPPPDYHHHHQQHRLTSNDNGG---INREQQPPASTPGDQRNSALLALQGSLKRKQIVNLSPANSKRPNGFPDSSFLDIKRIRVGENFSTGQGSLPVNNGQSHMMPGPLPMNQAPLRKTNALPPSAHSPGNNLFNMGLKEVKKEPGETLSCSKHMDDQLTQESVFTNRFGDDPGDQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFGIDLGQQSQRSTPRPSLPMDKIIIKSEYSPGLTP---GSPQLRPPSAGPAFSLANSALSTSSPIPTVPQSQPQLQTVSGASRAPPSWQEVSHAQQLKQIAANRQQHVRMQQQQQQQQQQQQQQQQPPPSWPALQSSAGPSPGAFVQEKIP-SPSFGQQPFSPQGSPMPGVTGSSNQSKAAGNYTYKASPSAQTGHLDVLLHQKPQDLSRGFINNPHPTLEPRHGNTKPLFHFNSDQANQQMP----SQSKPSLLHYTQQQQPQLQPQSQQQQQQQQ-----------------QQQQQQQQQQGSLAAQQQQ---QAQSSLAAQQQQQQQQQQQQQQ------QQQQQQQQQQPS-QPTQALSSQPLLRSPLPLQQKIMLQKMQNQSIAGLGYQVTQQHRQDQHSVVGQSTGPSPSPNSCSNPNTGSGYMNSQQSLLNQQMMGKKQTLQRPTMEQKQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRNAGSLQPAAQYSGGPSSVSLNSNQALTNPVSTHTILTSNSSLMSTSHGMRMPLLST-VQNIGMYGNLPCNQPGTYSVTSAMNQLTQQRNTTQLITNQNNPLMPRPPPLGASTGNNAAAFGAGPAGSPQQLRPNLAHGLAGMTAQRSSTVMITASTTATNWASQEVTGKQQEALKPTGVRFPTSTP-AYTPNQSLQPGVGSQPFSQRAVAPPSQLTPAVQMRPVNQMNQTLNGQTLGPLRGLNLRPNQLTTQNLSNMNPPGTGLNPPRTGANQPPSLTPNTFPSSNQSSRAFQGPDHGSDLAFDFLSQQSDSMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGSNS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F6U238-1", "uniprot_id": "F6U238_MOUSE", "id": "F6U238-1", "name": "", "aln": "MGDTAPPQAPAGGLGGASGAGLLG--------GGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTMQLLSLVQHGQGARKASKHAKATVATATTTAPPPPPTAPPVASQAAAT-APPPPPDYHHHHQQHRLTSNDNGG---INREQ-PPASTPGDQRNSALLALQGSLKRKQIVNLSPANSKRPNGFVDSSFLDIKRIRVGENLSTGQGGLPVNNGQSQMMPGPLTMNQAPLRKTNALPPPAHSPGNNLFNMGLKEVKKEPGETLSCSKHMSDQMTQESVFTNRFGDDPGDQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFGIDLGQQSQRSTPRPSLPMEKIIIKSEYSPGLTQGTSGSPQLRPPSAGPAFSLANSALSTSSPIPTIPQSQPQLQTVSGANRALSSWQEVSHAQQLKQIAANRQQHARMQQQQQQQQQQ------PSPSWPALQSSAGPSPGAFVQEKIP-SPSFSQQPFSPQGSPMPGVTGSNTQSKAAANYTYKASPSAQAGHLDVLLQQKPQELNRSFINNPHPALEPRHGNTKPLFHFNSDQANQQMPSLLPSQSKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGSLAAQQQQQQPQPQSSLVAQQQQQQQQQQQQQQGSLTAQQQQQQQQQQQPS-QPTHALSSQPLLRSPLQLQQKIMLQKMQTQSITGLGYQVTQQHRQDQHTVVGQNTGPSPSPNSCSNPNTGSGYMNSQQSLLNQQMMGKKQTLQRPTMEQKQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRNTGTLQPAAQYSGGSSTVSLNSNQALTNPVSTHTILTPNSSLMSTSHGMRMPLLST-VQNIGMYGNLPCNQPGTYNVTSTMNQLTQQRNTTQLITNQNNPLMSRPSPLGANNGNNVATFGAGSAGSSQQLRPNLAHSLSGMSAQRSSTVMITANTTATNWASQEVTGKQQEALKSTGVRFPTSTPAAYTPNQSLQPGVGSQPFSQRAVAPPSQLSPAVQMRPMNQMNQALNGQTLGSLRGLNLRPNQLAAQSLSNMNPSGTGLNHPRTGTNQPPSLTPNAFPSSNQSSRAFQGPDHGSDLAFDFLSQQSDSMCPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGSNS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IZL2-1", "uniprot_id": "MAML2_HUMAN", "id": "Q8IZL2-1", "name": "Mastermind-like protein 2", "aln": "MGDTAPPQAPAGGLGGASGAGLLG--------GGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPT---------NWSALPSSAGPSPGPFGQEKIP-SPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQ------------QQQQQQQQQQQQQQSSISAQQQQ---QQQSSISAQQQQQQQQQQQQQQ---QQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RIA2-1", "uniprot_id": "A0A8M1RIA2_DANRE", "id": "A0A8M1RIA2-1", "name": "", "aln": "MGEAAPTQATPSGFAPMLGVGMGGSITPMATSRGSAVPQLHSAIVERLRARIELCRRHHSTCENRYERGLAENSDREHESTLQLLNIVHQGPGTRKTKGSRSASQHPSEFIRG---------------------------------------------NGEHKGHGASDAESKISSQIAQG---LRRKIEAQSPGYTPKQNGLSCGASGSNFKRLRMESSSFRPGTCALAAGQTQRLVGDSTHGNILQRKD----TFMTSHGIDVFNITLKDIKKEPIEVQTCGQATTDPSMLVFDFKDEVIG-----QIDPDLQDLFDELT-KSVPSFNELEFEKML----KQDDDFGLDLGRPSSAGAAPPCVHLDKP-IKTEYSSDLSHTTGGSQQLRPASAGPSFSMANTTLSTSPITSGLHGQVP----SGGASRGHPAWPEISHAEQLKQMAANQLQPNSILHNHQQSQVR---------NWSSTLG-VHQTLGSFPQETLPGNASLSQQRLNPQ---------NTGQPKGLTNCFLKPNGFNQSHNVDAKILSN-----------------------KPLLHFSPKAPPSTTG-------------------------------------------------------------------------QQMPVMTVPPNKTTMQQQQAPS-----AGQGRHFQNCQLPMQPSSCLQTKPPSQ-----------RPLLNQHGAGISFKLTQQRQ-----------GISSAPRLPVNGRPVDLPSQVQQQRPPQKNPNQEQNLQR-------QLGQPQPNIADMEKLNTQDQFSRHLTRPPPDYKHPRNGVG-APQTSLYSGN---------------VSDQSDIQSLSCQLANAPGAKMAASGERRFPLGQD--------------------------------------PNSGPTGAQACANQQPGGLSRMG----LQPNKTQFHGTNSQGGAFQLVRTSVSQDSLLGQRLSDSRMDAALNWATSAKQSGLDVKRLPNAVAPQ--SDVHFAPRSICPPNQVAPHSSLLPLNPANRSS-----------APRSSQPRIPPLPGVNQSSVEQQG-----------CPSTFGGMNQSPVTYQN-NRAGRLTFDFLPE-DDNTVPGINADSDFIDSLLKSGSGNDDWMKDINLEEILGGHS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::**.**...*:. *.*: * **..*::************ :**:** :**.***** **.****:***:***.:*::* *:**: .*: .: * *: .:: .:.: *: :* *::: **. : : **: .: . : *. * * : **:: : * . .: ** . * * .:**: **::**** *. :*.: . * :. . :**:**:**:*** ***.:.:**:*:*: **** *.:***: *. .:. *.: ::* **:***..*: ** ****.****:**:**::****. . : . . .**.*. .:* *:***:****:***: * : :::** * .*.: . . : *.* **.:* ..*:.** :.** .. *.* * *.. * ::*. : .: ***:**... . . * . : . :: **** . * :: *: * . **: .* ::* : : : .* :*:.::::**:: * *.:*. * .. . : **. *: .::*.*** ** * :** **: .***:.***:*******. *...* :: ***. ** :: : . *. ::.: * :*. . :* ... . *.. * . * . * *:** :: . . : :: *: : . ..: .: : **. : :. ** .. *: *::.**.*::* .: *:* .:: *..* *..:* ... : *. * . ***. ::*. ::.. *:****.: .*. *.:*:*:********: .***********:****.:*", "identical_positions": 297, "similar_positions": 298, "identity": "24.92%" }, { "cls_id": "homologset.agr.HGNC:16260", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D9X8-1", "uniprot_id": "SACA3_MOUSE", "id": "Q9D9X8-1", "name": "Sperm acrosome membrane-associated protein 3", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGICMSMYTQVLVPVDADG---------------------------DHHILWSRFYERWGSCFNPCAGLVNCLPPHSSALYLCHRMEARSRAPRRQL-CPPGITWLALAY-------LLSCLLASSKAKVFSRCELAKEMHDFGLDGYRGYNLADWVCLAYYTSGFNTNAV-DHEADGSTNNGIFQISSRRWCRTLASNGPNLCRIYCTDLLNNDLKDSIVCAMKIVQEPL-----GLGYWEAWRHHCQGR---DLSDWVDGCDF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M6E7-1", "uniprot_id": "F1M6E7_RAT", "id": "F1M6E7-1", "name": "Sperm acrosome membrane-associated protein 3", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEARSRAPRRQP-CPPGITWLALAY-------LLSCLLASSKAKVFSRCELAKVLHDFGLEGYRGYNLADWICLAYYTSGFNTDAV-DHEADGSTNNGIFQISSRKWCKNLAPNGPNLCRIYCTDLLSNDLKDSVACVMKIAQEPQ-----GLGYWESWKHHCQGR---DLSDWVDGCDF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IXA5-1", "uniprot_id": "SACA3_HUMAN", "id": "Q8IXA5-1", "name": "Sperm acrosome membrane-associated protein 3", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSALRGAPLIRVHSSP---------------------------VSSPSVSGP-RRLVSCLSSQS---SALSQSGGGSTSAAGIEARSRALRRRW-CPAGIMLLALVC-------LLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAYFTSGFNAAAL-DYEADGSTNNGIFQINSRRWCSNLTPNVPNVCRMYCSDLLNPNLKDTVICAMKITQEPQ-----GLGYWEAWRHHCQGK---DLTEWVDGCDF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VSA5-1", "uniprot_id": "Q9VSA5_DROME", "id": "Q9VSA5-1", "name": "lysozyme", "aln": "MLRWPVVCLLLPLLATAKIFDRCELANLLQHRFGLPAAQVATLVCIAQHSSDFNTAAFGGGVGLGGGSHGLFQISDVYWCSPPGQGKGCGLSCSRLRDDDIADDVLCVRKIYAEHQRISGDGFTAWQAYDAYCRQDANSYVAGCGGPGSSALSVAASYHKPQQVQVHSYPVQQYHQVAQIQPQGKIYSRCELAQELYYQHKLPMPQIPTWVCIAQHESSFNTAAVGRLNADGSADHGLFQISDLFWCTHEQRAGKGCHATCNQFLDSSIGDDVQCIRRIHQEHTQISGDGFNAWTVYKRNCLNQHYEQIAACFAKPPAHQPQHHPNAIAGGPVKSKVSYAYQYGQVQVHQTPIAPAVNQYYRPPQPSPVLSYQTNVAAYSGNPFLRPRPVNPPRQHPNAIGVPLKNQTPANPFYIHKQQTQYQPQYQTHFQTHYQRTGKVYNRCELAQELYFSHKFPMQDLATWVCIAEHESSFNTTAVGRLNADGSADHGLFQISDLYWCTHNDGGGKGCHIDCNRLLDSDITDDVKCVRTIHEEHTRISGDGFTAWTVYNGHCRQKTRADVANCFDGKDLPAEVAKPSKGNELVKKTSPTPKAKIYNRCELAKELYHR--HKFPMREIPTWVCIAEHESSFNTAAVGKLNADGSEDHGLFQISDIYWCTHDQTSG-KACHIECDRLLDSDISDDVQCIRTIHEEHTRLSGDGFNAWTVYNGHCRNQNLAKLSDCFDGNEISEADKTSHYGERPQVMPHQSVPQKPQHKTATIQEYAGNPFLQNLQAAKPPQPTLNKNKLTNNVVAPKEQKTNKLYATNPFFNGQVQSKPPPTQGAPVYSTKKPNYDHNPFLKAPGSVTPSVKPSHASQEVKLHDSTSYAQNPFLSLLGKPIVPAQAPIKPQSKPPSPSKSTQLVSRPYVSSDSFRNEVIKFTATSAAVATTASFTKQSVTTTTRKPQTASTTKPVSTTAKTTSLPLWSWQTSTTAKPTISESGNRYTTSTTRSVITNKPNTHPTIAAVSRPTTRATTRSTNGPIRTTSQPGTYLNTPLSSRSPIRQSTIRSSTVFTTRSTTRPTIRSTTHAISRPTSSPTTRPTTRLTTRPTTRTTTRASVSPTTRPTVGLTTYQPTRTPTSITRRPIYTTQKQYTTTTRATTPYPTVSKPTTRPSTTTRPLTTTRYIPTTRQSVITQTTNRNSAIYLPRNNTISTNRSTTKSPYHYVSINKPTTRSTTSTRPSTTIRYSPTTRQPPTTRSTTRYSAITAFSTRQTSTTPRPYLFTSTTKKSVTTKDPFDHPFFQKFKAKFEKTTTTTNQKASTLAVNQNQTTISPYYAKYQENKVKTGAKTVLSYDFGQNRNTTSRPKSAFDVYLNWNKN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W4C2-1", "uniprot_id": "Q9W4C2_DROME", "id": "Q9W4C2-1", "name": "lysozyme", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRAAP---------FGSWYWLGLGLG-----LLLAIECGVVSAKRFLRCELARKLLDQ--HGFERSLLSNWICLLEHESDLDTGRI-TTNANGSRNYGLFQINGR-FCQEGRRGG--ICNAKCEDFLDENLRESVTCAKRIQTSDG------FRHWAGWQRYCRNAQ--NLPNLKVICGI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A1ZBX6-1", "uniprot_id": "A1ZBX6_DROME", "id": "A1ZBX6-1", "name": "lysozyme", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCLKARHPKTKRDLMNMKTFCLWIVPVL-----ILLQLGIEQVESKKYQRCELTRVLVEN--YNFDKTFISNWICLVEHESYLDTTKV-TKKGNESKNYGLFQINSKDYCSEGRKGG--QCNMKCEDFSNDDISDDIACARMIQEREG------FKYWKGWDRFCRNPQ--NLPNLRVACNLRSLSPVRSPRGFLTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. *: .:* : ****:: : . : :. *:*: . * ::: : :.: * : *:***.. :* . *. * : . :: : : * * : * : .*:. .*.: : ", "identical_positions": 22, "similar_positions": 45, "identity": "1.61%" }, { "cls_id": "homologset.agr.HGNC:16261", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q76M99-1", "uniprot_id": "S22AO_RAT", "id": "Q76M99-1", "name": "Steroid transmembrane transporter SLC22A24", "aln": "MAFQDLITQIGCLGRFQILHLIFVLICFILVVPHTVLENFTAAIPSHRCWVPILDNNTMSDNNSRILSQDDLLRISIPMDSNLRPE-----KCRRYIQPQWDLLHLNGTFSTVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQTLNSVAKFIYMTGIFIGHLMGGHLSDKFGRKFIVTCGLLTLAVTETSVAFAPTFLIYCSLRFLTGISSSCIRTNSALLILEWTSPKFQAMVMALIFSAGGIGQVLLGVLAFGIRNWQHLQLAMSVPVFFLLIPTRWLSESARWLIITNKPQEGLKELIKVAHINGIKNSRDVLTLEVVKTTMKDELEAAETK---PSPLVLFRTPNLRKRICLLSFVRCVSLISTVGLLINLQYLSNKVFLLQCLYG--VVCTPANLLGNFSMNYMGRRTTQIIFMSVMG--------ISILSITFLTQEMQIPRLVLASLGGAISSASLTSTAVLSNELVPTVIRATALGVIGIFGSAGAALSPLLMILMTYSASLPWIIYGVLPILS--SLVVLLLPETRNQPLPDSIQDVENKRKSSREVKK-DAVAKVTPF--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCA0-1", "uniprot_id": "S22AJ_MOUSE", "id": "Q8VCA0-1", "name": "Solute carrier family 22 member 19", "aln": "MAFQDLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRILSQDDLLRISIPLDSNLRPD-----KCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLLGGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNRIKNSGDALTLEVVKTIMKEELEAAQTK---PSPLDLFRTPNLRKRICLLSFVRFVSVMSLLGLLINIQYLSNNVFLLQCLYG--VVCIPANVLGNFSMNYMGRRMTQLIFMSVLG--------ISILAVVFLPQEMQILRVFLSTLGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILPFLG--GLVALLLPETKNQPLPDSIQDIENKRKSSKEAKK-DVVAKVTPL--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O70609-1", "uniprot_id": "O70609_RAT", "id": "O70609-1", "name": "", "aln": "MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNGNLSQDDLLRVSIPLDSDLRPE-----KCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTFLSTIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQTVLAGLAFTVRNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVVRTIMKEELEASQTK---SSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLRINVFLLQCLLG--IITIPANLVGIFLVNHLGRRISQLFIISLFG--------ISILAIIFVPQEMQILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSFLG--GLVVLLLPETKNQPLPDSIQDVENEGRASRQGKQNDTLIKVTQF--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I6ANT8-1", "uniprot_id": "A0A8I6ANT8_RAT", "id": "A0A8I6ANT8-1", "name": "", "aln": "MAFQELLNQVGGLGRFQILQMVFVVFTSVIVVPHIIIENFTAAIPSHRCWVPILDNVTVSDNDSRILNQDKLLKISIPLDSHLRLD-----KCRRFAQPQWHLLDLNDTFSSITEPDTEPCVDGWVYDRSNFHSTTVTEWNLVCESQALNSVTKLSFMIGAFIGGIVNGLLSDRFGRKFILKYALLQMAITETCAGFAPNLFIYCSLRFLAGMSLEPITVNINLLMFEWTSPKFLTMVTVLGSCAGSFGGMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVINKPQKGLKELKKVAHINGMKKSGDNITMEVVRTSMKKELEAAKMR---PSPRDLFHTPILRKQIYILSFIRLLFILSGVGVAIHLQHLSNNIELLQILIS--VSSILFSVIGHFVLNHIGRRITQMVIMFLRG--------ISILTAIFAPQEMETLRFIMAMMAEGLAALSYAANSLHANELLPTTLRATARGVIGMFGNIGFFLAPLCMMLASYSPNLPWIFYGGFAILS--GFIVLLLPETKNNPLPDCTHDVENDWKESRQEMKEDPIIKVTRF--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q76M72-1", "uniprot_id": "S22AR_MOUSE", "id": "Q76M72-1", "name": "Solute carrier family 22 member 27", "aln": "MSFQELLNQVGSLGRFQILQIVFLLLLNAIVVPHIAMENFTAAIPNHRCWVPILDNDTASDNGSRILSQDDLLRISIPLDSNLRPE-----KCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAALLSCAPNIGYMISAGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGD-LTMEIVRTSMKAELEAAKTK---PSLRDLFHTSILRKRICVLSFMRLFFTVSIFGLAVHLQHLSSNIILLQFLIS--ALAILVSVIGPFVLNHIGRRITYLVLMSLRG--------IFILIAVFVPQEMQTLRIIMATLAEGISSLCVGVSRLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYYANMPWIFYGGFSIFN--AFTVFLLPETKNQPLPDSTHDVGNDWKESRKGKKEDPIIKVTRF--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IVM8-1", "uniprot_id": "S22A9_HUMAN", "id": "Q8IVM8-1", "name": "Organic anion transporter 7", "aln": "MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRPE-----KCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKK--PSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFG--AVILLANCVAPWALKYMNRRASQMLLMFLLA--------ICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFIS--GFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VDS0-1", "uniprot_id": "Q9VDS0_DROME", "id": "Q9VDS0-1", "name": "Solute carrier family 22 member 13", "aln": "-MVNPSPARGGESTAPHILPNEMENDVDKRIATPPPAPAGSDVIADVVGDFGIWQLRTILIIFLCKIPAAWFMACIIFTGPELYPGSEFTCDTSYLTSSSNSSFSISDNQCYVLDESTGTSSECEQFNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYWTPDSPRWLLRHAADRFSIDNVEQILREGAAINDRSFKIPPDFRQQLEQLSERLKAQPPPAPWTELWKGKRAKTHMVAAHLALAFFVINFMGMLLNIRSFGRDYLVPNTIAMGFSEIIGCFLALHFTLKHNKWKWQCAGVFNILAGILGCMGWIFTNADSMDADLKVSLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFSILGGICTSLLLTPRLSVSPVVPHLEQRNTKEQSPLNAPVWTVESDVNNTRL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: : * :** : : *.. . * : * : :: * ...: . .. : :... : . .. : :: . .: : :::*** : : : :: .: * ::* :: : :. : : : . .. * : ::*::* *:.: : . :: : : . * .. *: .. * : : ::.* :.::: * :*.***: . .:.:: : . : . .: :: * : : .. : : .:: : : .*: ::.: : . : : : : ::: : .: : . * : .: .:: : . **::*: : . :*: :* :. * :.::. :* *. .*: .: .. : . : .*. ", "identical_positions": 38, "similar_positions": 173, "identity": "6.62%" }, { "cls_id": "homologset.agr.HGNC:16262", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q2EJA0-1", "uniprot_id": "YAP1_RAT", "id": "Q2EJA0-1", "name": "Transcriptional coactivator YAP1", "aln": "MEPAQQPPPQPAPQGP-APPSVSPAG--------------TPAAPPAPPAGHQVVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLG---AGTLTASGVVSGPAATPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPTSAS--PAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRLDPRFAMN-QRITQSAPVKQPPPLAPQSPQGGVLGGGSSNQQQQIQLQQLQMEKERLRLKQQELFR----------------QELALRSQLPS-LEQDGGTQNAVSSPGMTQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSEIL-DVESVLAATKLDKESFLTWL---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P46938-1", "uniprot_id": "YAP1_MOUSE", "id": "P46938-1", "name": "Transcriptional coactivator YAP1", "aln": "MEPAQQPPPQPAPQGP-APPSVSPAG--------------TPAAPPAPPAGHQVVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTASGVVSGPAAAPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPAPAS--PAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRLDPRFAMN-QRITQSAPVKQPPPLAPQSPQGGVLGGGSSNQQQQIQLQQLQMEKERLRLKQQELFRQAIRNINPSTANAPKCQELALRSQLPT-LEQDGGTPNAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSEIL-DVESVLAATKLDKESFLTWL---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P46937-1", "uniprot_id": "YAP1_HUMAN", "id": "P46937-1", "name": "Transcriptional coactivator YAP1", "aln": "MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTS--PPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMN-QRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPT-LEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1L8J7-1", "uniprot_id": "YAP1_DANRE", "id": "Q1L8J7-1", "name": "Transcriptional coactivator YAP1", "aln": "MDPNQHN----------------------------------------PPAGHQIVHVRGDSETDLEALFNAVMNPKNTIVPPSVPMRLRKLPDSFFTPPEPKSHSRQASTDAGTAGTVTPHHVRAHSSPASLQLGAVSPGALTS----MGPANAP-PQHLRQSSYEIPDDMPLPPGWEMAKTPSGQRYFLNHNDQTTTWQDPRKALL-QMNQAAPASPVPVQQQNIMNPASGPLPDGWEQAITSEGEIYYINHKNKTTSWLDPRLDPRFAMNQQRISQSAPVKQGSQLPS-SPQSGVMSGNNP-----IRLQQIHIEKERLRIK-QELLRQ-------------RPQELALRNQLPTSMEQDGGTQNPVSSPGMGQDARNMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMETGDTLGPGSMATQPSRFPDYLDAIPGTDVDLGTLEGESMAVEGEELMPSLQEALSSDILNDMESVLAATKIDKENFLTWL---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q45VV3-1", "uniprot_id": "YAP1_DROME", "id": "Q45VV3-1", "name": "Transcriptional coactivator yorkie", "aln": "MLTTMSASSNTNSLIEKEIDDEDMLS--------------------PIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQPDG-------------QSPIAAIPQLQIQPS----PQHSRLAIHHSRARSSPAS---LQQNYNVRARSDAAAANNPNANPSSQQQ---PAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYD--VISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAER----------------IKQNDVLQTTKQTTTSTIANNLGP-LPDGWEQAVTESGDLYFIN--HIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDN----------------------------------------------------LCSNLFNDAQAIVNPPSSHKPDDLEWYKIN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . :.: :*:*. *:: :*:***::*:** : * :*:*:****:***.** *. ::: .: **: :. :: ::* .. * .* : ::: * *:. *. . *::.... *:: :. : .*. * : * .: . .: : :: :*.* : : : : .:. . ::. . : : : *: :* *.. *. . .* : * . : : * : * *: : .. * : : .* .* : : . .*:*.* :: . : .* * :. *. *: **:::.*:: :. *.*::: * :::: ... .* . * * ", "identical_positions": 67, "similar_positions": 139, "identity": "13.11%" }, { "cls_id": "homologset.agr.HGNC:16263", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8JZX9-1", "uniprot_id": "BORG1_MOUSE", "id": "Q8JZX9-1", "name": "Cdc42 effector protein 2", "aln": "MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGDDMFGDISFLQGKFHLLPGTAVEEAEEDGSFDLPFQFTRTTTVCGRELPDGLSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLESPQPSPQPSPQGAGNVDVWRIPEAGSPHNGMSPEPEAEEPFLSHASSLLSLHVDLGPSILDDVLQIMDHDLGRVQIPT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5PQP4-1", "uniprot_id": "BORG1_RAT", "id": "Q5PQP4-1", "name": "Cdc42 effector protein 2", "aln": "MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGDDMFGDISFLQGKFHLLPGTAVEEAEEDGSFDLPFQFTRTTTVCGRELPGGLSPLLKNAISLPVIGGPQALTLPTTQAPPKPPRLHLESPQPSPKSSPQEAGNVDIWRVPEAGLPHNGMSPEPEAEEPFLSHASSLLSLHVDLGPSILDDVLQIMDQDLGRVQIPT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O14613-1", "uniprot_id": "BORG1_HUMAN", "id": "O14613-1", "name": "Cdc42 effector protein 2", "aln": "MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSP----QEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "************************************************.******************* ** .****:**********:********.* ***********************:************:***** * .*.**:**:**:* *:.*::**. *******:************************:**. :****", "identical_positions": 182, "similar_positions": 21, "identity": "85.05%" }, { "cls_id": "homologset.agr.HGNC:16264", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XHZ0-1", "uniprot_id": "TRAP1_RAT", "id": "Q5XHZ0-1", "name": "Heat shock protein 75 kDa, mitochondrial", "aln": "MARELRALLLWGRGLQSALRAPALAGVRRGKPVLHLQKTTVHFRDPTQSLASGISAGQLYSTQAAEDKKEEALHSIISNTEAVQGSVS-KHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKRVCEG-QVLP----EMEIHLQTDAEKGTITIQDTGIGMTKEELVSNLGTIARSGSKAFLEALQH-----QAETSSRIIGQFGVGFYSAFMVADKVEVYSRPAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFANESRVQDVVTKYSNFVSFPLYLNGRRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFILHYKTDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFVRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTTAEQDIKEDIAKLLRYESS-ALPAGQLTSLSDYASRMQAGTRNIYYLCAPNRHLAEHSPYYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPAGERLSEKETEELMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHTLIKKLNQLREREPELAQLLVDQIYENAMIAAGLVDDPRAMVGRLNDLLVKALERH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQN1-1", "uniprot_id": "TRAP1_MOUSE", "id": "Q9CQN1-1", "name": "Heat shock protein 75 kDa, mitochondrial", "aln": "MACELRAVLLWGRGLQTVLRAPALAGVRRGKPVLHLQKTTVQFRGPTQSLASGISAGQLYSTQAAEDKEEESLHSIISNTEAVRGSVS-KHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVCEG-QVLP----EMEIHLQTDAKKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLEALQN-----QAETSSKIIGQFGVGFYSAFMVADKVEVYSRSAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFASESRVQDVVTKYSNFVSFPLYLNGKRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFTLHYKTDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKAADILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTTAEQDIKEDIAKLLRYESS-ALPAGQLTSLPDYASRMQAGTRNIYYLCAPNRHLAEHSPYYEAMKQKHTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPADERLSEKETEDLMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHTLIKKLCQLRESEPELAQLLVDQIYENAMIAAGLVDDPRAMVGRLNDLLVKVLEKH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q12931-1", "uniprot_id": "TRAP1_HUMAN", "id": "Q12931-1", "name": "Heat shock protein 75 kDa, mitochondrial", "aln": "MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLG-PRRNPAWSLQAGRLFSTQTAEDK-EEPLHSIISSTESVQGSTS-KHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDG-QALP----EMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQN-----QAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESS-ALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z6L9-1", "uniprot_id": "A1Z6L9_DROME", "id": "A1Z6L9-1", "name": "Heat shock protein 75 kDa, mitochondrial", "aln": "--MSVRAMGVLGQACRLGRCAQVLRQSHRSAP-----------------AAFNITIGSQHSPG------ALSLRRYSTETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKTDCREYADEERIKAVIKKYSNFVGSPILLNGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGKPGLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKEMREE--SKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNRFALLQPELEINPKHPIIKKLNKLRESDKDLAQLIAKQLFANAMVGAGLAEDPRMLLTNMNTLLSRALEKY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:**: : *: : * .* . * * .: * .*. .*: :.*: . **. ********::***********::***:*************:*:. :. * : *. :**:: *: : *********:**************** **: :: .:*:**.***********:*:**::***::*.*.* : * :* :****.:** *...*. **:*::***:**::::.* *:: *:.******. *: ***:: * ::.:*:::*:.: : **.:***:::::.* **: ***::*.**.*::::*.*: **.:*::**: .:.****:******:*: .:*******::******************:*:***** .*:. *:*:*: ::***:.*:* *:.*****::*****::: . **:******:*** : .:. ** :* . : * :*****.**** *** *****::*::. ****:* :***.*::* :*..***:***.:: : .:*. . . * ..* : *:.*:.: * .:* :**.* ******.::** **.*****:* *. .:::* **** *****:*.:**** :** : ****:..*:: ***:.***.:*** :: .:* ** :.**::", "identical_positions": 335, "similar_positions": 222, "identity": "46.66%" }, { "cls_id": "homologset.agr.HGNC:16265", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M064-1", "uniprot_id": "A0ABK0M064_RAT", "id": "A0ABK0M064-1", "name": "Protein Wnt", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKCMMPVSLMLSQERRLRLRRLPMCDRCRRPASEIPPQKLRLRSLRPVSPREMCFRERSGAPL----------------------------------WKMLVPGHWDGLRPAMPSLLLLFVAALLSS--------------------------------------------WAQLLTDANSWWS--------------LALN-------PVQRPEMFIIG--------------AQP-----------------------------------------------------------------------------------------VCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNLSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKN---------------------------------------------------------------------------------------------------------FAKGSEE----------------------------------------QGRALMNLQNNEAGRRAVYKMADVSCKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELTNSRFNQPSPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGTDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEIVDQYVCK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P22726-1", "uniprot_id": "WNT5B_MOUSE", "id": "P22726-1", "name": "Protein Wnt-5b", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSLLLVVVAALLSS--------------------------------------------WAQLLTDANSWWS--------------LALN-------PVQRPEMFIIG--------------AQP-----------------------------------------------------------------------------------------VCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKN---------------------------------------------------------------------------------------------------------FAKGSEE----------------------------------------QGRALMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELANSRFNQPTPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEVVDQYVCK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H1J7-1", "uniprot_id": "WNT5B_HUMAN", "id": "Q9H1J7-1", "name": "Protein Wnt-5b", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSLLLLFTAALLSS--------------------------------------------WAQLLTDANSWWS--------------LALN-------PVQRPEMFIIG--------------AQP-----------------------------------------------------------------------------------------VCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKN---------------------------------------------------------------------------------------------------------FAKGSEE----------------------------------------QGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q92050-1", "uniprot_id": "WNT5B_DANRE", "id": "Q92050-1", "name": "Protein Wnt-5b", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRMNQGHLLLAVTLIVC--------------------------------------------NSQLLVVANSWWS--------------LAMN-------PIQRPEMYIIG--------------AQP-----------------------------------------------------------------------------------------LCSQLTGLSQGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMHIGSRETAFTYAVSAAGVVNAVSRACREGELSTCGCSRAARPRDLPRDWLWGGCGDNVNYGYRFAREFVDAREREKN---------------------------------------------------------------------------------------------------------YPRGSVE----------------------------------------HARTLMNLQNNEAGRMAVYNLANVACKCHGVSGSCSLKTCWLQLADFRRVGEFLKEKYDSAAAMRINRRGKLELVNNRFNPPTGEDLVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTYKHERCHCKFHWCCYVKCKRCTSLVDQFVCK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P28466-1", "uniprot_id": "WNT5_DROME", "id": "P28466-1", "name": "Protein Wnt-5", "aln": "MSCYRKRHFLLWLLRAVCMLHLTARGAYATVGLQGVPTWIYLGLKSPFIEFGNQVEQLANSSIPLNMTKDEQANMHQEGLRKLGTFIKPVDLRDSETGFVKADLTKRLVFDRPNNITSRPIHPIQEEMDQKQIILLDEDTDENGLPASLTDEDRKFIVPMALKNISPDPRWAATTPSPSALQPNAKAISTIVPSPLAQVEGDPTSNIDDLKKHILFLHNMTKTNSNFESKFVKFPSLQKDKAKTSGAGGSPPNPKRPQRPIHQYSAPIAPPTPKVPAPDGGGVGGAAYNPGEQPIGGYYQNEELANNQSLLKPTDTDSHPAAGGSSHGQKNPSEPQVILLNETLSTETSIEADRSPSINQPKAGSPARTTKRPPCLRNPESPKCIRQRRREEQQRQRERDEWFRGQSQYMQPRFEPIIQTINNTKRFAVSIEIPDSFKVSSEGSDGELLSRVERSQPSISSSSSSSSSSSRKIMPDYIKVSMENNTSVTDYFKHDVVMTSADVASDREFLIKNMEEHGGAGSANSHHNDTTPTADAYSETIDLNPNNCYSAIGLSNSQKKQCVKHTSVMPAISRGARAAIQECQFQFKNRRWNCSTTNDETVFGPMTSLAAPEMAFIHALAAATVTSFIARACRDGQLASCSCSRGSRPKQLHDDWKWGGCGDNLEFAYKFATDFIDSREKETNRETRGVKRKREEINKNRMHSDDTNAFNIGIKRNKNVDAKNDTSLVVRNVRKSTEAENSHILNENFDQHLLELEQRITKEILTSKIDEEEMIKLQEKIKQEIVNTKFFKGEQQPRKKKRKNQRAAADAPAYPRNGIKESYKDGGILPRSTATVKARSLMNLHNNEAGRRAVIKKARITCKCHGVSGSCSLITCWQQLSSIREIGDYLREKYEGATKVKINKRGRLQIKDLQFKVPTAHDLIYLDESPDWCRNSYALHWPGTHGRVCHKNSSGLESCAILCCGRGYNTKNIIVNERCNCKFHWCCQVKCEVCTKVLEEHTCK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. :* * :.*: ::* .:: *: : :. :** * . *** .*:* * : . * *..**::.*:***.**::*******.:: :*** : :.: * ** :*::** *.. ::****:*:*::*.*** :**::* ** *******:::.*:** :*:*:**:*.* : :*. : :.* ****:****** ** : * ::************ *** **:.:*.:*: *:***:.*: :::.::*:*:: : :*. *: .**:*:* ***:* .. : **:**:*:*.*.* :.* ::******: : ***:*:***** *:*: **.::::. **", "identical_positions": 153, "similar_positions": 125, "identity": "15.24%" }, { "cls_id": "homologset.agr.HGNC:16266", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E7F6V3-1", "uniprot_id": "E7F6V3_DANRE", "id": "E7F6V3-1", "name": "", "aln": "---METLKRWM-KDWKYPTSLLFIYGFFSTVKPLEPFLYPFLTGPDKNLTTEQLNNQIFPVWTYSYLAVLVPVFLLTDWLRYKPVVVFQSLILFCTTSMLLWCNGVPEMQAMQFTYGVVTSCDVAYFTYIYSMVEIKHYLKATSYCRTAHLLGYTVGSVLGQILVSLELMSYNNILVFTLVLTGIAMIASILLPMPKVSMFFHKKQSEEDDNEGHSGNVKPLEPEEGFGTMVDLSNDVKVDETK-------WQQDVLDGSNGCDSSSAKSSKSSRKAGCGDVLLRLWRDFLQCFSSRTLLLWSAWWALATCGYNQTVNYVQSLWEHVEPSSNFTVYNGGAEALSNLFGAAAAYGIGLSSAD--WSRWGEMALSALSALEGGALFAMVFSGNIWVCYGGYILFKSLYMLLITIAMFQIAAGLNMERYALVFGANTFCALVLQTIITSVVVDSRG-LGVDVVTQFIINGAYFSVIAVIFFLRGLY--TTMCRKPET---------------------DTSRE----------NLEEAFKKDAQ---------------IVTETKL----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q1LV16-1", "uniprot_id": "Q1LV16_DANRE", "id": "Q1LV16-1", "name": "", "aln": "------MRR---SDWVFPTVLLSLYGFFANCRPAEPFLTPYLVGP-KNISEEVVTNYLFPIWTYSYLSLLCPVFLLTDLLRYKPLIVAQGLFLVTNYIILSFANSLPALTYLQFNFAVVTSTEVAYFSYIYSVIPPERYQRATGYVRSAMLAGYTFGAILGQMLISLANTSYFHVNTVTLSLMIVALCISLSLPMPQHGVFFKKKQVEVS---------------------MDTMNEVADGGS---------SRDLEKEVTGRSVKICEYIKTSGKQ--------MWESLKESYSSRRLVQWSLWWALATAGYGQVFNYVQLMWDHIEPSSTSSVYNGGVEAVCALVGAAAAFSVGYIQVQ--WGVWGELSLGVFSAVGAGCVFLMGLTNSIWLSYAGYAIFKASYMFLITITMFQIAVNLSMECYALTFGINSFVALTLQTILTAIVVDNTA-LGLDIATQGLYTVCKHFCTSTVTNTEALT--VIMEDQRKS---------------------DTSGKQETQSSSSSSSLQNKEQSALQ---------------AYTETAL----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0ABK0L0X6-1", "uniprot_id": "A0ABK0L0X6_RAT", "id": "A0ABK0L0X6-1", "name": "", "aln": "MVAMNCCRTPPRDSWVYPTVILCLFGFFSMFRPSESFLIPFLSGPSKNLTSTEMTNEILPVWTYSYLAMLPPVFVLTDYLRYKPIIMLHVMAFTICYLFLLFGQSVMLMQTAEFFFGIVSATEIAYFAYIYSMVSPEHYQKVSSYCRSITLVSYTAGSVLAQLLVSLMNVPYSTLFYISLACVSVAFFVSLFLPMPKKSMFFHTKPNREA-----------------CPKPLEPCTVLKEAHN--------NGAQPELFANAQNLGDREQ-----DNSALRIFVYWFQDLKECYSSKHLVYWSLWWAFATAGYNQILNFVQVLWEQKAPSKDSSIYNGAVEAIATFGGALASFSVGYIKVD--WDLLGELGLAVFSAVVAGSLLLMNYTLSIWVCYTGYVLVKSSYSFLITIAVFQIAVNLSLERYALVFGIDTFIALVIQTIMTMIVADQRG-LQLPVTTQLSAERKCRTLLPPRALVSHTYKSQEMCQRSSNPVTSTPVTKGQDFKMGSQKSFATHRHPIRTDSKTTTKLHPQANRPAHCKHSIYDHGSYISYFLDAMTKYLTRNNSREELKCFSSQFGGMHSITKEKI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PL8-1", "uniprot_id": "S19A3_MOUSE", "id": "Q99PL8-1", "name": "Thiamine transporter 2", "aln": "--MDSSCRTPPSNSWVYPTVILCLFGFFSMFRPSEAFLIPFLSEPSKNLTSPEMTNEILPVWTYSYLATLPPVFVLTDYLRYKPVIMLHVVAFATSYLFLLFGQGVMLMQTAEFFFGVVSATEIAYFAYIYSMVSPEHYQKVSSYCRSITLVAYTAGSVLAQLLVSLTNLPYSSLFYISLACVSVAFFFSLFLPMPKKSMFFHAKSDRDD-----------------CPKPLEQCTVPKEAQS--------NRTHSELFANSKNLEDREMSNPDPENSALRHFAHWFQDLKECYSSKHLVYWSLWWAFATAGYNQILNYVQVLWEHKAPSQDSSIYNGAVEAIATFGGALASFSVGYLKVN--WDLLGELGLAVFSAVIAGSLFLMNYSRSIWVCYAGYLLVKSSYSFLITIAVFQIAVNLSLERYALVFGIDTFIALVIQTIMTMIVVDQRG-LQLPVTTQFLVYGSYFAVIAGVFLMRSIY---ILCS-------------------------AKCRKEVQNLATTRSPNEPHPQEPS-----------------NVSTKF----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZV2-1", "uniprot_id": "S19A3_HUMAN", "id": "Q9BZV2-1", "name": "Thiamine transporter 2", "aln": "---MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSRE------------------IKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVN--WDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRG-LNLPVSIQFLVYGSYFAVIAGIFLMRSMY---ITYS-------------------------TKSQKDVQSPAPSENPDVSHPEEESN---------------IIMSTKL----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VGV6-1", "uniprot_id": "Q9VGV6_DROME", "id": "Q9VGV6-1", "name": "Thiamine transporter 1", "aln": "-----------MESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLITDLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRVTSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNRSEAIEG------------------------------------------GTKSDGGNLEKGSEQPSNEEASQEKKIPALQLLWSHFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVWKSFENEP-TIAWNGAVDVALTLLSAVFALLAGYFHAGRLNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEEDSFALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVIL------------------------------------QYIWSISKKPKAIQEAN-------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VGV5-1", "uniprot_id": "Q9VGV5_DROME", "id": "Q9VGV5-1", "name": "Thiamine transporter 1", "aln": "-----------MKEWLKISCLLCVFGCIREIRPSEPYVTEYLLGPWRNITEQQLTHDVYPVGTYSYLVQLVFVFLITDFLRYKPLIITIGAAGVIIWSMLIWTTSLLSLQILEFFFGTYMAAEVAYYTYIYAKVDKKYYARVTSHTRAAMFAGKLVSGITSQLMLNLELMNYKELNYITLGTQIIAMLWAFGLPRVDRSLYFHREQLSITE------------------------------------------PQTQLPG-VGNLAEMDQQQENTQ-KQPGALSLLWLHFRNAYTNPRVVQWSLWYAIGLAGYLQVTYYVQVLWKVIEPEP-VIAWNGAVDAVLTALAALSALAAGYLHTGRLRPRASLLILGILSAVEGGCVLICCWTQDIYWSYAGFVLFGALYGFTITVASAEVARNLEEESFGLVFGVNTFVALIFQSLLTIIFVTDTG-FELDPVGQYTAYAFYFIGVGVLYLISVLI------------------------------------EYLMCRNNDVEKLENSLD------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VK64-1", "uniprot_id": "Q9VK64_DROME", "id": "Q9VK64-1", "name": "Thiamine transporter 1", "aln": "-----------MKSWLKISLLLCTFGFFREFRPSEPYVTEYLASDYGNLTTDQIYQDVYPFGTYSVLAQLVIVFLITDLVRYKPVIVLSALAGITLFSMLIWTETVGMLQVAQVFFGTFTAAEVAYYTYMYAKVNKEQYQVVTGHTRAAILSGKFLGGLFAQILVSTDSMDYRQLHYLSLATQLISLAVSLFLPSVPRSLYFYAGSEKIT---------------------------------------------------IADGEETSPKFSFAN-----ACRLLWYHLVSSYSNPVVLQWSIWWALATCGQVQVISYIQFLWKEVAPNK-LSVYNGGVEAVATLLGAIGAILAGLLNSNKRRG-SYMMGISICAAALGALLIYAAKTQLIWVAYVNYVLFCTVFFFIITVAGAVVAENLVEDSFGLIFGINTLVGLILQTILTVAVVERVG-FALEPRDQYVVYGSYFVVLGGISIIGSIC------------------------------------VKLFCRTNK-SSVENVVSLT----------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..* : :* :* : :* *.: * ::: : . : *. *** * * **::** :****::: * : : : :. :. : ::**::*:*: : : * .:.: *: : . ..: .*:::. * : .:: :: :: ** .::* . . : : ..::. :. ** *:*:. .* * ::* :*. . :**..:. .* : * : : :. .. :: : *: .* .: : : : **:: :* .* : :.* ** ::: .* :* ::* .. . : : * ", "identical_positions": 57, "similar_positions": 126, "identity": "9.64%" }, { "cls_id": "homologset.agr.HGNC:16267", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3K6-1", "uniprot_id": "D4A3K6_RAT", "id": "D4A3K6-1", "name": "Protein Wnt", "aln": "MDRAALLALPSLCALWAAVLSLLPCGTQGNWMWLGIASFGVPEKLGCSGLPLNSRQKELCKRKPYLLPSIREGARLGIQECRSQFRHERWNCMV-ATATSTQLATAPLFGYELSSGTKETAFIYAIMAAGLVHSVTRSCSAGNMTECSCDTTLQNSGSASEGWHWGGCSDDVQYGMWFSRKFLDLPVRNTTEKESKVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGYFLKDKYENSIQISDKTKRKMRRREKDQRQTPILKDDLLYVHKSPNYCVENKKLGIPGTQGRECNRTSGGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTSLNHRVFFLLTSLGPFKNPWQEYSKYRGECQQQTTELRIEPPLKESEKELEELEGA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QYS1-1", "uniprot_id": "WNT16_MOUSE", "id": "Q9QYS1-1", "name": "Protein Wnt-16", "aln": "MDRAALLALPSLCALWAAVLSLLPCGTQGNWMWLGIASFGVPEKLGCADLPLNSRQKELCKRKPYLLPSIREGARLGIQECRSQFRHERWNCMV-ATTTSTQLATAPLFGYELSSGTKETAFIYAIMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSPSEGWHWGGCSDDVQYGMWFSRKFLDLPIRNTTGKESRVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHFLKDKYENSIQISDKTKRKMRRREKDQRQTPILKDDLLYVHKSPNYCVENKKLGIPGTQGRECNRTSGGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UBV4-1", "uniprot_id": "WNT16_HUMAN", "id": "Q9UBV4-1", "name": "Protein Wnt-16", "aln": "MDRAALLGLARLCALWAALLVLFPYGAQGNWMWLGIASFGVPEKLGCANLPLNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMGASPLFGYELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTDVHTCK------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A5WVL3-1", "uniprot_id": "A5WVL3_DANRE", "id": "A5WVL3-1", "name": "Protein Wnt", "aln": "MDNTG-CGIHAVHHLFLIWLSVYPLCSQGSWMWLGITSVGVPEKLGCAHLPLSHKQKELCARKPHLLPSVKEGARLGITECQTQFRHERWNCST--------RRDPNVFGYELTSGTKETAFIHAVMAAGLVHAVTRSCSAGNMTECSCDTSLLGSGSPTEGWHWGGCSDDIAFGTSFSRRFIDSAAKNTSTRGEEALLIMKQHNSEAGRQAVAKTMLTDCRCHGVSGSCAVKTCWRTMAAFERVGAYLKDRYETSVHVVDRSKRKVRRKDKEQRHVPITKDELIFFNKSPNYCLEDRRLGVTGTRGRKCNRTSAGPDGCNLLCCGRGYNTHVVRHVERCECKFVWCCYVRCRRCETMNDMHTCK------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.:. .: : *: * : * :**.******:*.********: ***. :***** ***:****::******* ** :********* . :*****:*********:*:*******:*****************:* ..**.:***********: :* ***:*:* . **: : ...** *: **.********* * .*****************:**::**::* ***:**.*::: *::***:**::*:**: ** **:*::.:******:*:::**:.**:**:***** *.***************************:***********:*.*:**. ", "identical_positions": 234, "similar_positions": 79, "identity": "55.85%" }, { "cls_id": "homologset.agr.HGNC:16268", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3TRM4-1", "uniprot_id": "PLPL6_MOUSE", "id": "Q3TRM4-1", "name": "Patatin-like phospholipase domain-containing protein 6", "aln": "---------MGTPSHELNTTSSGAEVIQK-------TLEEGLGRRICVAQPVPFVPQVLGVMIGAGVAVLVTAVLILL---VVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRK--EPPPS------------VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPD------------------------------------------------------------GKECVVKEVVPGDSVNSLLSILDVITGHQHPQR--------------------------------------------------TVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPG---------------------LPTRTSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAP--------------------LLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPR----ELREQPAGACEYSYCEDESATGGCPFGPYQGRQ-----------------------TSSIFEAAKRELAKLMRIE--DPSLLNS----------------------------------------------------------------------------------------------------RVLLHHAKAGTIIARQG-DQDVSLHFVLWGCLHVYQRMIDKA-----------------------EEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSG-----------KKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGN-----------------LQQLQGPFP-GSGLSVPQHS---ELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIG-PTLLLNSDVIRALLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTP-WTVRCLRQADCILIVGLG-DQEPTVGQLEQMLENTAVRALKQLVLLHREEG-PGPTRTVEWLNMRSWCSGHLHLRCPRR---------------------------LFSRRSPAKLHELYEKVFSRRAD-------------------RHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRI-EPPTSYVSDGCADGEESD---------------------------CLTEYEEDAGPDCSRDEGGSPE--GASPSTA-SEVE---------------------------EEKSTLRQRRFLPQETPSSVADA------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M0R715-1", "uniprot_id": "M0R715_RAT", "id": "M0R715-1", "name": "lysophospholipase", "aln": "---------MGTPSHELNTTSSGSEVIRK-------ALEEGLGRRICVAQPVPFVPQVLGVMIGAGVAVLVTAVLILL---VVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRK--EPPPS------------VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPD------------------------------------------------------------GKECVVKEVVPGDSVNSLLSILDVITGHQHPQR--------------------------------------------------TVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPG---------------------LPTRTSPVRGSKRVVSTSGTEDTPKETSGRPLDPTGAPLPGPAGDPVKPTSLEAPSAP--------------------LLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRTPTQELREQPAGACEYSFCEDESATGGCPFGPYQGRQ-----------------------TSSIFEAAKRELAKLMRIE--DPSLLNS----------------------------------------------------------------------------------------------------RVLLHHAKAGTIIARQG-DQDVSLHFVLWGCLHVYQRMIDKA-----------------------EEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSG-----------KKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGN-----------------LQQLQGPFPAGSGLSVPQHS---ELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIG-PTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTP-WTVRCLRQADCILIVGLG-DQEPTVGQLEQMLENTAVRALKQLVLLHREEG-PGPTRTVEWLNMRSWCSGHLHLRCPRR---------------------------LFSRRSPAKLHELYEKVFSRRAD-------------------RHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRI-EPPTSYVSDGCADGEESD---------------------------CLTEYEEDAGPDCSRDEGGSPE--GASPSTA-SEVE---------------------------EEKSTLRQRRFLPQETGAQ----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IY17-4", "uniprot_id": "PLPL6_HUMAN", "id": "Q8IY17-4", "name": "Patatin-like phospholipase domain-containing protein 6", "aln": "MEAPLQTGMMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILL---VVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRK--EPPPA------------VLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPD------------------------------------------------------------GKECVVKEVVPGDSVNSLLSILDVITGHQHPQR--------------------------------------------------TVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPG---------------------LPTRTSPVRGSKRMVSTSATDE-PRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAP--------------------LLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQ-----------------------TSSIFEAAKQELAKLMRIE--DPSLLNS----------------------------------------------------------------------------------------------------RVLLHHAKAGTIIARQG-DQDVSLHFVLWGCLHVYQRMIDKA-----------------------EDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSG-----------KKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGN-----------------LQQLQGPFPAGSGLGVPPHS---ELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIG-PTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTP-WTVRCLRQADCILIVGLG-DQEPTLGQLEQMLENTAVRALKQLVLLHREEG-AGPTRTVEWLNMRSWCSGHLHLRCPRR---------------------------LFSRRSPAKLHELYEKVFSRRAD-------------------RHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRI-EPPTSYVSDGCADGEESD---------------------------CLTEYEEDAGPDCSRDEGGSPE--GASPSTA-SEME---------------------------EEKSILRQRRCLPQEPPGSATDA------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B6R2-1", "uniprot_id": "A0A8M2B6R2_DANRE", "id": "A0A8M2B6R2-1", "name": "lysophospholipase", "aln": "----------------MGQSTSDTESAEP-------PETDRFGNIKSLVEDQLQTSMVVGIVIGAGVVIVLIAVLIFF---VLRRMQLRKLEAQEVPKYRFRKRDKVLFYGRKIMRKVSQSTSSLVG--ATSSTRPRLKKKQKMLNIAKKILRFKKEVPTLQMK--EPPPS------------VLEADLTEFDVANSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFLQFQQGEYVFRPGQPDSSIYVVQDGKLELCLTGQD------------------------------------------------------------GKDGVVKEVYPGDSVHSLLSILDVITGHQRPYK--------------------------------------------------TVSARAAEVSTVLRLPVDAFLSIFEKYPESLVRVVQIIMVRLQRVTVLALHNYLGLTNELFSHEMQPRSSPLSP----------------------HPTRSSPVRHSKRFGSLTVPDKHREAAVQN----------ATGGDHGK----EGGTIP--------------------TLSRTISMPVDIAGMQKSLRSDFDMAYERGRISVSAEDGVP--AFTKEQRERKVTVDEVPSG--VYLYPEEESGMD--IFSSFQGRP-----------------------NATVFEEAQKEILRLMKIE--DPSLLNG----------------------------------------------------------------------------------------------------RVTFHHAKAGSVLARQG-DQDVSLHFVLSGCLHVYQKMIDKQ-----------------------EAVCLFVTQPGEMVGQLAVLTGEPLIFTIKAERDCTFLKISKSEFYEIMREQPSVVLSAAHTVAIRMSAFVRQMDFAIDWMAVEAGRALYRQDDQSDCTYIVLNGRLRSVIRKANG-----------KKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELVKLPEGTLNNIKRRYPQVVTRLIHLLGQKILGN-----------------LQQPRGPFS-SSALGLPSMASSPDVTNPASNLSTVAVLPVCDEVPINAFNLELSHALSAIG-PTLLLTSDIIRERLGASALDSIHEYRLSGWLAQQEDINRIVLYQTDSGMTP-WTQRCIRQADCILIVGLG-DQEPALGELEQMLENTAVRALKQLILLHREDG-PGPSRTVEWLNMRSWCSGHLHLKCPRR---------------------------VFSRRSPTKLREVYEKVFEKTAD-------------------RHSDFSRLARVLTGNSIALVLGGGGARGCSHVGVIKAMEDTGIPIDIVGGTSIGSFIGALYAEERSAVRVKQRAREWSKAMNSVFKTVLDLTYPITSMFSGSAFNTSISKVFEDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGNLLMDGGYINNLPADIARTLGTKTVIAIDVGSQDETDLCNYGDCLSGWWLLWKRINPWAEKVKVPDMAEIQSRLAYVSCVRQLELVKKSAYCEYIRPPIDRFKTMDFGKFDEIYDVGYQHGKLVFTEWARGDIIDNMLKDHRSADYNDSKKTDSCPCPSADFTDLAEIVSRI-EPVQSYVG---ADAEESD---------------------------YATEYEEDGMDTVREEEGEEEEEEGEDPEDQ-SPGEWGPNGVFPP------------------DEDKTVRQRKNVSRDPNADFSGVSDC---------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9U969-1", "uniprot_id": "SWS_DROME", "id": "Q9U969-1", "name": "Neuropathy target esterase sws", "aln": "---------MDVLEMLRASASGSYNTIFS------DAWCQYVSKQITATVYMYFALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSG-------QMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAE------------YLEETIEG----SDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNAD------------------------------------------------------------GSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYK--------------------------------------------------TVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKS---------------------------VSTMSGPINSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVT----VTRPPS--------------------SPSRHSREEHTLSDPNPNPDGSFHGTTN---LFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSID-----------------------MRLVQSSAVDSLRKELGLSEEDSHIIEP----------------------------------------------------------------------------------------------------FVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDK-----------------SDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGG-----------KKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGS-----------------MQTR-------SGSGAPGAP--VEANPVTHKYSTVALVPITDEVPMTPFTYELYHSLCAIG-PVLRLTSDVVRKQLGSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSA-WTQRCMRQADVILIVGLG-DRSHLVGKFEREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKR---------------------------IFTRKSQYRINDLYSRVLLSEPN-------------------MHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRFN---QWFNKEPPKRVNHASLNEYTFIDLAQIVCRLPETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDSDVELDLKLERKTDKSTQSSPPSNSRSDMRGKEEARHMSNWHWGVKHKDETGSGATEATKTQTGQEQELQQEQQDQGATAEQLVDKDKEENKENRSSPNNETKN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04958-1", "uniprot_id": "NTE1_YEAST", "id": "Q04958-1", "name": "Lysophospholipase NTE1", "aln": "--MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSAN-APPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQN-ARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKASYSSSLSHKP--QNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERY-VEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLAGLLPPLEE--NGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIP--------GSQETTLNSQVPEFLLHRRNSI----------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ... :... . . : : :. : :: : : : : : . .: . : . : **. : : . :.. :*. ::::*::***:* * :: .: *: :: . :: : : : * *. :: * *:.: **:*:::::: .: *:* ..: :* ::* : . * :::*::: :* :* . : ::****. *:.. .: . * . . .. . . . . ** . : . . . . : : : : : : :. : : . : :: : . : :. . : ::: * : * . :. . .* :** *: * * .: :. . : : : .:: : * .. :. :*. : : *.*::* :.:..::: *.: :: *:**.**:*.: : . :: ::** .:*: .* ** :* * :*: ****:**.::*. : : .:* :: :: ::.::::*. : . . . . : . : . *::::*: :*: .* :* ::: :* ..: *.. ** :: : : :.::*: *: .:* *: :.. ** *: *.* **::. . . . :*: *: : . : .:*:**: * * * .**. *.* * *: *:*:: .: .: : : :.** **** *:*::*.********** :*:*:::*::: *:*:*::**.***:::*.*:..: . :.:::: :.. : ***:*:** :* ** * .* * ***:*: *: :*:** * .:*. * ***:*:**:*:* :*** : :* :*:****::***. : * ::*:**** *: *** *.*:*::::: **::. ::*::.:** **.**:.*. ** .*.: *:**.*: : *: *..*::* .** .*: : : : . . . : .* ", "identical_positions": 220, "similar_positions": 404, "identity": "11.85%" }, { "cls_id": "homologset.agr.HGNC:16270", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35308-1", "uniprot_id": "MOT3_MOUSE", "id": "O35308-1", "name": "Monocarboxylate transporter 3", "aln": "------------------------------------------------------------------------------------------------------------------------------MG-AGGPRRGAG-------------------------------------------------------------------PPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRELK---RDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLVELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSMLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPPPRRD-----------------------------------------------------------------------------------------PSPHGGPAR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRRLLDVAVCTDRAFVVYVVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKN---YEIIFYLAGSEVALAGVFMAVTTYCCLRCSKNISSGRSAEGGASDPEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPEQEPEEEAVPELDHESIGGHEARGQKA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O70461-1", "uniprot_id": "MOT3_RAT", "id": "O70461-1", "name": "Monocarboxylate transporter 3", "aln": "------------------------------------------------------------------------------------------------------------------------------MG-AGGPRRGAG-------------------------------------------------------------------PPDGGWGWVVLGACFVITGFAYGFPKAVSVFFRELK---RDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPD-----------------------------------------------------------------------------------------PAPPGGRAR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKN---YEIIFYLAGSEVVLAGVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPE--PEEEAVPDLSHESVGGHEAHGQNA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O95907-1", "uniprot_id": "MOT3_HUMAN", "id": "O95907-1", "name": "Monocarboxylate transporter 3", "aln": "------------------------------------------------------------------------------------------------------------------------------MG-AGGPRRGEG-------------------------------------------------------------------PPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALM---RDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPR-----------------------------------------------------------------------------------------RDSAGDRAGDAPGEAEAD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKN---YEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTE--PEIEARPRLAAESV----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5K3-1", "uniprot_id": "A0ACD6B5K3_DANRE", "id": "A0ACD6B5K3-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------MGGIVEDRETAG-------------------------------------------------------------------APDGGWGWVVLLGGFVITGFSYAFPKAISVYFKELM---HDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLLNCCTCGAVMRPLKLKERKACN----------------------------------------------------------------------------------QELKEMLPPEAGQEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVCENNNDKKPSKKKLLDFSVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKN---YELIFYMAGGELITAGIFLALASFCCISQKKRKDS--------PQTQQTYVEVNPER---------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0L6-1", "uniprot_id": "Q9W0L6_DROME", "id": "Q9W0L6-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------MVDTNSSNPGIVGGNSASSARLRRFERTDSELACEEAARLTAEQSPEDEDNQDNDEDDDDE-----------------ESVYGELPPPPDGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFV---AYFHEGKGTVAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPLTYPKKKKQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQAGGGGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESENSPYHSQDAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEAGAGGDFASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYEKSMQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAGLYVPFVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVADLPQVN--SLLLNNCCLLVSTIAVTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALIGTPLAGAIYDMTHT---YDLPFYMAGALFGIS-TITSFLAPCLKRCSPSEETPVHVETLTPIDEEQGEDAEDDEDQPITIVPKIIKTLASPQQEEGHPQFPQKTSESKL----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53918-1", "uniprot_id": "ESBP6_YEAST", "id": "P53918-1", "name": "Uncharacterized transporter ESBP6", "aln": "MSTHSNDYFSASSGMVSETSSEVSSINSSQPVSFSKASIAAPVPCSDLHSTKSNDASRKLSISRTLTNRLNDIKKAVDDDNLQTEENSADVNKILESRFDVADAIRLQHNESVQSKLNIPVTHTTTAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLMRNRLYPASTKHSGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIALLKERNPTPAIG---------------------------------------------------------------------------------------LKSPRAMFEQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKAMFSLKVITKPFVVLIALWFMFALFAYNMMVFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMG-LAGDKFGRANVTIVLTTLLTIYMFAFWIP--AHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLVCEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMKLTERQAMTNEKLKEWKASEYDTDSADEDWGKLKERKTKYDLLLGPGIKKYFLRMVYPMKV------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . .****:***: *: . :..: : . * :..: : .*: : * *.. : *. : . : ::*:: : * * *.: * .:.: : *: : :* :*.:* *:: *: . : . :* * *: . *: . . ::.. : . . : : :: . : . * . * . .:.. :*: * :*:. : ..* * :*. . . . * :: . . : : :.: .* . . : :: : .: * .:: . *: * : .. * :.* . : : :. . . : ", "identical_positions": 44, "similar_positions": 126, "identity": "4.51%" }, { "cls_id": "homologset.agr.HGNC:16271", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AU37-1", "uniprot_id": "RD21L_MOUSE", "id": "A2AU37-1", "name": "Double-strand-break repair protein rad21-like protein 1", "aln": "-------MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISP---------KVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFEIYNINEIDIS--EPLAQNQSRPEEITLREEYSNDLLFQAGSFGDEPEILRRHSFFDDNILMNSSGLVVEHSSGSFAEEKSLFFDNGDGFGDEGAAGEMIDNLLQDE-STFLEEAYLNKEVSLPPELPSSIMVEPGNSDDQCIPEDEEINEITLLSNEDEGFTLDPIDDLDIADRRRRKKRRLLVDPVKEISSKAMHRQLASFMDTLMVLDLAPPTQRLMMWK-----KRGGVDMLLSTATQDLINDELKMLFTKCFLSSDYKLA-KLTLKESVRKEVGNQQIAEPSVMGEPNSHSELDQPQDWKDVTDESVGSFQENVNMNVNSEQDILGMISPAVEGLSSMNGSLAQEN--CPAELE--SSGSKQNTEAEKWNQRLFQTLNVLREFNKMGMQSFSLKKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSVPYADIIATVGPMFYKM----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ADQ7-1", "uniprot_id": "D4ADQ7_RAT", "id": "D4ADQ7-1", "name": "", "aln": "-------MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIQKIISP---------KVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFRPGLVDLPKENFEAAYNTITLPEEFHDFDIYNTNDIDIS--EPLAQNQSRPEEITLREEYSTDLLFQTGSFGDEPELLRRHSFFDDNILMNSSGLVVEHSSGSLTEEKSLFFDNGDGFGDEGAAGEMIDHLLQDE-NTFFEDTYLNKEVFLPPEVPSSVMVEPGNSDDHYIPEDEKINEITLISNEEEGFTLDPIDGLDIADRRKRKKRRLLIDPVKEISSKTMHKQLTSFMDTLMVLDLAPPTQRLMMWK-----KRGGVETLLSTATQDLINEDLKMLFANCFLSSDYKLA-KLTLKESLRKEVGNQHILDPSVVEEPNSHSELGQPQDGKDVTDESMGSFQENINRNINSKQDILEMISPAAEGFSLVSASSAQEN--HPAELE--SSGSKQNTEAEKWNQRLFQTLNELREFNKMGMQFFSLIKLCRNSDRKQAAAKFYTLLILKKHRAIELSQSAPYADVIATVGPMFHKL----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H4I0-1", "uniprot_id": "RD21L_HUMAN", "id": "Q9H4I0-1", "name": "Double-strand-break repair protein rad21-like protein 1", "aln": "-------MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSP---------KVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFEASYNAITLPEEFHDFDTQNMNAIDVS--EHFTQNQSRPEEITLRENFDNDLIFQAESFGEESEILRRHSFFDDNILLNSSGPLIEHSSGSLTGERSLFYDSGDGFGDEGAAGEMIDNLLQDDQNILLEDMHLNREISLPSEPPNSLAVEPDNSECICVPENEKMNETILLSTEEEGFTLDPIDISDIAEKRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWK-----KRGGVHTLLSTAAQDLIHAELKMLFTKCFLSSGFKLGRKMIQKESVREEVGNQNIVETSMMQEPNYQQELSKPQTWKDVIGGSQHSSHEDTNKNINSEQDIVEMVSLAAEESSLMNDLFAQEIEYSPVELE--SLSNEENIETERWNGRILQMLNRLRESNKMGMQSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMFYNI----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q12158-1", "uniprot_id": "SCC1_YEAST", "id": "Q12158-1", "name": "Sister chromatid cohesion protein 1", "aln": "MVTENPQRLTVLRLATNKGPLAQIWLASNMSN-IPRGSVIQTHIAESAKEIAKASGCDDESGDNEYITLRTSGELLQGIVRVYSKQATFLLTDIKDTLTKISMLFKT---SQKMTSTVNRLNTVTRVHQLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQENSMERKVQGAAPWDTSLEVGRRFSPDEDFEHNNLSSMNLDFD---IEEGPITSKSWEEGTRQSSRNFDTHENYIQDD------DFPLDDAGTIGWDLGITEKNDQNNDDDDNSVEQGRRLGESIMSEEPTDFGFD----LDIEKEAPAGNIDTITDAMTESQPKQTGTRRNSKLLNTKSIQIDEETENSESIASSNTYKEERSNNLLTPQPTNFTTKRLWSEITESMSYLPDPILKNFLSYESLKKRK--IHNGREGSIEEPELNVSLNLTDDVISNAGTNDNSFNELTDNMSDFVPIDAGLNEAPFPEENIIDAKTRNEQTTIQTEKVRPTPGEVASKAIVQMAKILRKELSEEKEVIFTDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPALFERFINA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . * :::****:****:: .: :.:. *:: :: : ::* .. : *:*****.** *:**:*.::*.:**:* .::: *:.* * . . . *::* .:: : . . : :: : :: : * : :*: : : .:. . *: **.* :* * *. ::.. : . :* :.. : :: :**: : *: : : : : .*.: *: . ::* * .* :* ** .. : : *.:.* ..* : * . ::: *:. *. . **:. . :: * :::.: : :: **:::. : . : **: : .*. .: . . . * :* : : : . . . :. :* .* : .. . : : : *. :* .: . . .* :::*: *: :* * .. .* ***: .:.:: * :.: ", "identical_positions": 83, "similar_positions": 191, "identity": "14.19%" }, { "cls_id": "homologset.agr.HGNC:16272", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96JK9-1", "uniprot_id": "MAML3_HUMAN", "id": "Q96JK9-1", "name": "Mastermind-like protein 3", "aln": "-MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNS--------------GTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEP-EFS-QPATETPLSQESAS--VKSDPSHSP---FAHVSMGSPQARPSSSGPPFSTVSTATS-LPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNP-------AAVTVAGSASGP-------VAVP-SSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTN---SLNKQHNILTYGNTKPLTHFN--ADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPG---FLGS---QPQAAIMKQMLID---QRAQLIEQQKQQFLREQRQQQQQQQQQ----------------------ILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQA-ALQSMRTSRLMAQ----NAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYN-MSTGMTQMLQ-----HPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKG--PVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQP-RLTKQHFPQGLS-QSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPS----GSFAPSSQSQAYERNAPQDVSYNY---SGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6ABZ3-1", "uniprot_id": "A0A8I6ABZ3_RAT", "id": "A0A8I6ABZ3-1", "name": "", "aln": "-MGDFAAPAAAANGGSICINSSLSSSLGGAGIGVN-TPNSTPVAPSSNHPAAGGCGGSGGPGGSSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKAQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGSFSPTSKRIRKDLSTGLEAINNLPSNMPLPSASPLHQLDLKPSLPLQNS--------------AVHTPGLLEDLSKNGRLPEIKLPVNGCGDLEDSFAILQNKDLKQEPLDDPACIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEQ-EFS-QTAMETPLSQESVS--VKSDASHSP---FAHVSLGSPQARPSSSGPPFSTVSTGTS-LPSVANTPVAPNPASSPANCAVQSPQTPTQAHTPGQAPPRPGNGYLLNP-------VSAAVSGSGSGS-------VAVP-SSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQ------QQQQHSNQTSSWSPLGPPSSPYGTAFASEKPNSPMMYPQAFNNQSTIVPAMANSLQKTTMNNYLPSNHMTMISQQPNNLGTN---SLNKQHNILTYGNTKPLTHFN--ADLSPRMTPPMANPSKTPLMPYIQQPPQPQPPQQQPPQQQPPPPPQLQAPRAHLSEDQKRMLLIKQKGVMNPPMAYAALPAHGQEQHAVGIPRTTGPMQNSVPPGSGGMVSGASPGGLG---FLGS---QPQAAIMKQMLMD---QRAQLMEHQKQQFLREQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQILAEQQLHQSHLPRQHLQQQRTPYPVQQVNQFQGSPQDIAAVRNQAVALQSMRTSRLMAQ----NAGMVGMGPSQNPGTMATAAAQSEIGLAPYSAPPTSQPGMYN-MNTGMTQMLQ-----HPNQSGMGIPHNQPQGPRQPASGQGVGVVSGFGQSMLVNSAFSQQHQQLKG--PVGQALPRPQGPPRLQSVMGTVQQGAQNWQQRSLQGVPGRTSGELGPFNNSASYPLAAGQP-RLTKQHFPQGLS-QPVMDGNPGAVRTLNPAAMGRQMMPPLAGQQGASQGRPLVIPGLSQGVPGMPAFSQPTAQQQIAG----GSFAAGNQGQAYERNPAQDMSYNY---SGEGAGASFPGLPDSTDLVDSIIKSGPGDEWMQELDELFGNP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M2B6W6-1", "uniprot_id": "A0A8M2B6W6_DANRE", "id": "A0A8M2B6W6-1", "name": "", "aln": "MMGDFASPAAVPTGGGICINNSN-----------------------VNLNSAINAANSGSTGGG--NIPKHSTVVERLRQRIEGCRRHHVNCESRYQQAHAEQLELDRRETVSLYQRSLEQRAKKS--NNSKQQ--SKQQEPDSSASAEQRNSTLIALQETVKRKLDSARSPLNGDQ-NGLSDGSYSPTTKRLRKEGCTGMDSLG------SLPPISPLHQMDIKPTLPSGNNSASSNNGTGNGNAGTNHITGRPEDLGKNGGMPDIKL--NGSLDLDDGFSLL--KDLKQEPLDDGAGIESSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDMHDLFNEDFEEKKEVSDFTRVTTEQTQLAQDPAPNSVATAPNSAPQPQSGQMPMGSPQVRPSSSGPPFATAASGTPPQQPLQQSPAVGMPSGSPANCVARSPQTPTQAQT--QAS-RPGNGFMMNAGPAVGPVGSTPVAGGGPGSGGTGGGGVPVPPTSELSPAEQLKQMAAQQQQRAKLIQQKHQQQ-----------------------SQAANWSPAGAPTSPYSGPFNPDKPNSPMMYTQAFNPSNTMGPKAP------SINNYLPQNHINMLNQQQQQQQPNNLAAQNSHNKQLSFSNTKPLTHFSGVDHMNQRMTPPMANQAKNPMMPYMQG----NAAQGGGPPQAPGPMP---SQTAHLSEEQKKMMILKQK-MMSQGLPYGPMQPHVQE--VVGLPRQAGGVQP--PHGGPGGVAPAGPNGAGPGGYLPNPQQQQQAAMMKQMMAMEQEKRVQLHLMEQQQKAQLMREQRQQQQQQ---------------------HMLAEQLQQQQHLPRQMTQAQRNPYPLQ---QFQGTSQEMAAR-NQT--LQNMRTARLMQQQQQQNPGMMQMTPVQNAAAMPT---QGDMSMA-YGGQAGAQTGMYQGMNPNMGQMLQQQQQHHPNQASMAMAQRQAGAGGQGMVGGGAG--AGYGQAMLMNPNLSQQQLKSAGVAPGGQPMAKAQVQ-RLQSMMGGGGQ-AWPQQQQNMQAMAGRTSNDMVAFNSNPAYAMQGGQPPRMAKQHFAQAMGGQTMVDP-----RSINPAAMGGPMMPHMAGQPRTNQPRGMVMPGMNQGVPNMAAFGQGPAQGMPGASGGGGPYMPGGQPQGYQRTSNQELAYGYGSQSGAGAGVSF-GLSDGTDLDS-------TEGWMEEF---FPNQ", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *****:***...*..****.* * :* ....**..**. :*************************.*****:.*****:**:*******:******** ...*** ** *: .:******* *** *********:.********* ** .**.:***:**:**: .:*::::. .**. *****:*:**:** *. * .* ***.*** :*:*** **. **:*.*::* ********** : *::*************************************::************ :*: .: :* *:*:... * : .. :* .::.:****.*********:*.::.*. .: .:*.. *:.*****..:*****.**:* **. *****:::*. :..*:*...*. *.** :*::*******************:***:*** .*::.*** *.*:***. .* .:********.**** ...: * . ::*****.**:.*:.** :: .* : *.::: *::.********. .:. *****:** *.*:***:* : * * * * : *****:**:::::*** :*. :.*..: .* ** **:** :* :* * *. * *: *.* * * :* . * ***:****: :*.** ::** : *:*:****** :**** :*.***** * **.***:* ****:.*::** .*: **.***:*** * *.**: : * **..:*.* *.::.:* *. . :*.***: *...* **** ****:.*.:.:.*. . * * *.* :*:**:**:*. ::**: : * * **.:.:.* ****:** * * **:.:*.:.****.:: .**...:*.: .*** *::****.*.:. *.::* *::****** *** :.** :.* * :*:.*:.****.*.**.* .** . *.: ...* *.*:*.. *:::*.* ** *** ** **.*.:** . : **:*: * * ", "identical_positions": 556, "similar_positions": 316, "identity": "45.06%" }, { "cls_id": "homologset.agr.HGNC:16273", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7F350-1", "uniprot_id": "F7F350_RAT", "id": "F7F350-1", "name": "Synapse-associated protein 1", "aln": "MFRGLSSWLG--------------LKQPEGAAA-GEEPPS--GDKLSSGAAPPEKSSEGLVEPTEEEEQ--------------LTEDPQFLHQAKGLG---------------------------------------------------------------------NYLYSFASAATK-----------------------KITESVTETAQTIKKSVEEGK-------IDDILDKTIIGDFQKEQKKFVEEQHTKKSEAAVPPWVESHDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRISLIKQSAQLTALAAQ-----------QQASGKEEKSSSRD-------------DNLPLTEAVRPKTPPVVIKSQLKNQEDE-EEISTSPGVSEFVSDAFDACN-LNQEDLRKEMEQLVLDKKQEEATALEEDSTDWEKELQQELQEYEVVAE-----------------------------------SEKRDENWDKEIEKMLQES---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D5V6-1", "uniprot_id": "SYAP1_MOUSE", "id": "Q9D5V6-1", "name": "Synapse-associated protein 1", "aln": "MFGGLSSWLG--------------LKPPEGAAAEGEEPPSRDGDKLSAGAAPSEESPERPVEPTEEQQQQP------------PTEDPQFLHQAKGLG---------------------------------------------------------------------NYLYNFASAATK-----------------------KITESVTETAQTIKKSVEEGK-------IDDILDKTILGDFQKEQKKFVEEQNTKKSEAAVPPWVESHDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRISLIKQSAQLTALAAQ-----------QQASGKEEKSSNRD-------------DNLPLTEAVRPKTPPVVIKSQLKSQEDE-EEISTSPGVSEFVSDAFDTCS-LNQEDLRKEMEQLVLDKKQEEATALEEDSTDWEKELQQELQEYEVVAE-----------------------------------SEKRDENWDKEIEKMLQES---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96A49-1", "uniprot_id": "SYAP1_HUMAN", "id": "Q96A49-1", "name": "Synapse-associated protein 1", "aln": "MFRGLSSWLG--------------LQQPVAGGG----QPN--------GDAPPEQPSETVAESAEEELQ--------------QAGDQELLHQAKDFG---------------------------------------------------------------------NYLFNFASAATK-----------------------KITESVAETAQTIKKSVEEGK-------IDGIIDKTIIGDFQKEQKKFVEEQHTKKSEAAVPPWVDTNDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDELLSKMRFALVPKLVKEEVFWRNYFYRVSLIKQSAQLTALAAQ-----------QQAAGKEEKSNGRE-------------QDLPLAEAVRPKTPPVVIKSQLKTQEDE-EEISTSPGVSEFVSDAFDACN-LNQEDLRKEMEQLVLDKKQEETAVLEEDSADWEKELQQELQEYEVVTE-----------------------------------SEKRDENWDKEIEKMLQEEN--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q960T2-1", "uniprot_id": "SAP47_DROME", "id": "Q960T2-1", "name": "Synapse-associated protein of 47 kDa", "aln": "MFSGLTNQFTSLVGAVKGGAGDEDVPAPTGDAPAAAPAASTSVEATASSAVDPEAAAAAGGEGLEGEEAGKRLPKSASLVDSLVSEATGWLGSAKGWLGNASIPSMPAMPSMPSMPAMPAMPSIPSIPGLRKGAGADGAEGAEGAVAGEGGAAASGAVSGGEDDDKSRYISATEGADSHPASGGGTPTGDEGQIGQGKGDEVKITTKVTQQAKHFGSFLSSAISKAGSKIKETVKDNTILDSFNKEQEAFIKGQGGVGN--GAAPWIGHANEAKIKEEILGLSQDRRNFVRAPPAGVDFEFSYDTAYPTAIAIMAEDKALETMRFELVPKIITEENFWRNYFYRVSLIIQAAELGTLGADGVGQASSGEDANEVATKEKKSKTAEPAKGDSSVKAIAEQPKAVIEPEAQECDVQAAKSKAKAKAQAGKELGQKISESEFVSDDFQASSESDLAEIQDGMRKLGIDSMTQQALAATDE-EQWEKDLEAELKDYEVVDEGGTGGDGGGGRRKGRKAGEDDTEADEDEPTISNLRTRSTNNDWEEYADLIEDTDDLK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** **:. : : * . . .. . . .* .. * * : : * .**. .*: .* :: *** .*:: *: : . :... : : *:**:..*:***: *:: * . ...**: :* .*:::**.** *:***:* *****:*:*.:* **.*:.:: **: *..*** ****::.** ********:*** *:*:* :*.*: ::.: **:**. : : .: *. : . **: * : : :*:. . . ****** *::.. : :::. *.:* :*. ::: . :: :***:*: **::**** * :.. :::*:: : : : . ", "identical_positions": 110, "similar_positions": 133, "identity": "19.86%" }, { "cls_id": "homologset.agr.HGNC:16274", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5PQS5-1", "uniprot_id": "CYYR1_RAT", "id": "Q5PQS5-1", "name": "Cysteine and tyrosine-rich protein 1", "aln": "MDALRLP--RRLGVLLWKVVLLFVYAEDCRAQCGKDCRAYCCNGSTPHCCSYYAYIGSILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAAHINAIS--YP-MAPPPYTYDHETEYCTDLPPPYSPAPQASAQRSPPPPYPGNSRKYSSSQNRICNN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VIH7-1", "uniprot_id": "CYYR1_MOUSE", "id": "Q8VIH7-1", "name": "Cysteine and tyrosine-rich protein 1", "aln": "MDALRLP--RRPGVLLPKLILLFVYAGDCLAQCGKECHSYCCDGSTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAAHINAIS--YP-MAPPPYTYDHEMEYRTDLPPPYSAAPQASAQRSPPPPYPGNPRKYSSSQNRIRDN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96J86-1", "uniprot_id": "CYYR1_HUMAN", "id": "Q96J86-1", "name": "Cysteine and tyrosine-rich protein 1", "aln": "MDAPRLP--VRPGVLLPKLVLLFVYADDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVS--SY-PGPPPYGHDHEMEYCADLPPPYSPTPQGPAQRSPPPPYPGNARK-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NYG4-1", "uniprot_id": "CYYR1_DANRE", "id": "Q6NYG4-1", "name": "Cysteine and tyrosine-rich protein 1", "aln": "MENPRSASLQKSWKFVRESLLLCLIAGRGEAQC-DGCIEYCCDGVPPFCCSYYAYVGDVLSGTAISGIVFGVVFLMGAVAAVFLCVCMCVKNSRGSRVGVFSSTYINTVTQGYPGPPPPPYSYDHEMFPPDLRPPPYTPTVPRSANYSPPPPYPGFSRK-----------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: * . : :: : :** : * *** . * ***:* .*.*******:*.:******:*****:**:**.:*.: :*:***:** *.:***:: :::**::: **** :*** ****:.: .*: ******** .** ", "identical_positions": 72, "similar_positions": 42, "identity": "42.35%" }, { "cls_id": "homologset.agr.HGNC:16275", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AC58GIM4-1", "uniprot_id": "A0AC58GIM4_DANRE", "id": "A0AC58GIM4-1", "name": "", "aln": "MRRHVQTSLTKSDVMRETPANFQQDQNPETPPILSPSQQESQSRRARRTEQSMSSSLPAQNKMDKQKLRPEIPPRVSKSSAQRLSRDLTCSICLDLFKQPVSLPCDHTFCEACITSYWSGPRVKCQAGSGSCPQCRKVFHGKSYRPNRIVANIVESYCQGMEESGVRLGAVSEPAPTAPLCMRHREELKLYCEEDQELVCLVCGISQDHRAHTLVCVQDAQKRYRAS--------------------------LTTSANALQKELNTALECERETEEEVKKLKDHTADLKQRIEAQFSELHQFLYQEEKLLQVKLKTEERRELIRLDEHKALLSVEISRLRRAVNDIEDKLSEQDPYTLLRSIKGLLQR---QPPKFERPTLTPPSLCEGRFAGPLQYRVWKSLKGSIYPVPSAITFN--------SKTANPWLSLTSSLTCVRYQTFNSSVQDNPQRFNAALSLMGGQGFTKGRHYWEVEVYSSTVWTVGVARESVTRKG-VINTMPANGFWTLSLSYGVQYMAGTSPPTLLSLEEPLARIGVYLDYKRGLVSFYNAESMTHLYTFRDTFTETLFPYFNLGFLDKVHENEPLKVFMPKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9C037-1", "uniprot_id": "TRIM4_HUMAN", "id": "Q9C037-1", "name": "E3 ubiquitin-protein ligase TRIM4", "aln": "------------------------------------------------------------------------------MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAP-----GGGPFPCPECRHPSAPAALRPNWALARLTEKTQR------RRLGPVPP-----GLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAMAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHFKQEEKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKS-QAPTLELLQNPKEVLTRSEIQDVNYSLEAVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWR-NPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFWLSPLASLVIPPVTDRK----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .*: :..:***.**** *::***: *.*.**..*: *: .*. .**:**: : *** :*.:.*. : ***.*. ** ** * *:*:**:**. ***** **:*::*::. :::* : **:. * .* . * :::..:. : ::..: **: . : **.::**:**:** :**.*: :*:.**.. :*:*:. *. *: *:: : :: :* : . **:. * :* * * ::. ::. ::*: : : *. ::: : .. . :.*. : :*..* ::*: . . *.. :**: .::* : **.*:****** .* :***.**.* : * *:*:: * . : * * . * .* *:***** * ****.* . .**:** : .. * *:* *. * .: . ", "identical_positions": 141, "similar_positions": 160, "identity": "23.5%" }, { "cls_id": "homologset.agr.HGNC:16276", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z3L3-1", "uniprot_id": "D3Z3L3_MOUSE", "id": "D3Z3L3-1", "name": "", "aln": "-MASQFMKNLKEEVTCPLCLNLMVKPVSADCGHSFCQGCITVYFESTKCDKEMFSCPVCRLSYQSSNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEKLQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAQEYKEQLQVVLQRLMADKKEFENWKDDLQKDRTYWENQIQKDVENVQSEFKRMRDIMNSEEKKELQKLKQEKENIINKLAESENEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIK-------------RSHTFSMKKPKAIAREQR--KFRAPDLQG----MLQVLQEVTEAQRYWVQVTLVQNNNPNIAITDDKR-------QIRYEDLQARNLEHGCENSHEGVLGHPVIQSGKHYWEVDVSGKGAWVLGLSDGSYLFNPIFRSNAERNP---LFRR----------GIKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPS--VLTLSLMVPPCRVGVFLDYAAGTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPMGSSEPMTICWPDS----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "E9PV98-1", "uniprot_id": "E9PV98_MOUSE", "id": "E9PV98-1", "name": "", "aln": "-MASQFMKNLKEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFESIKCDKEMFSCPVCRLSYQSSNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEKLQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAREYKEQLQVVLQRLMADKKEFENWKDELQKDRTYWENQIQKDVENVQSEFKRMRDIIDSEEKNELQKLRQEKEDILNNLAESESEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIK-------------RSLTFSMKKPKTIAREQR--KFRAPDLQG----MLQVLQEVTEAQRYWVQVTLVQNNHPNIAITDDKR-------QVRYEDHQASNLIHECENSHEGVLGHPAIQSGKHYWEVDVSGKGAWVLGLSDGSYLFCPIFHSNAERNR---LFCR----------GIKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPS--VLTLSLMVPPCRVGVFLDYAAGTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPTGSSEPMTICWPDS----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0L8F8-1", "uniprot_id": "A0ABK0L8F8_RAT", "id": "A0ABK0L8F8-1", "name": "", "aln": "-MASEFVMNLKEEVTCPICLDLMVEPVSGDCGHSFCQACITLNYESSKCNQDEFICPVCRVSYLFKNLRPNRHVANIVQRLKEFKSSPEEEPKVLSCARHGEKLQLFCKKDMMPICWLCERSQEHRGHQTVLIEEVVQEYKEKLQAALQKLMADKKEFENWKDDLQKERTYWQNQIQKDVENVQSEFKGMRDIMDSEEKKELQKLMQEKEDIMSSLEESENEYSQQSKLLGDLILDVEHQLQCSATEMLQVRLHELP-------------GSHTFSMRKPKTIPKEQRR-VFRAPDLQG----MLQVLQEVTEAQRYWVQVTLVESNNPNIFITADKR-------QIRYEDHQARHFARPTENCHAGVLGYPAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPLFRLNLSNDSHSRLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPS--VLTLSLMVRPCRVGIFLDCAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICWPDS----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A0G2JYE1-1", "uniprot_id": "A0A0G2JYE1_RAT", "id": "A0A0G2JYE1-1", "name": "", "aln": "-MASSVLEMIKEEVTCPLCLELLKEPVSADCNHSFCRACITPNYESNRNTEGQGSCPVCRVRYLFRNLRPNQHVAKIVESLKGFKSIPEKEQKVNVCAQHGEKLQLFCTKEMRAICWVCERSQDHRGHQTALIEELDHEYKRKLQDALQKLMEKEKTCDEWQENVQQQRTYWETQIQSDVEYIQKEFKLLRELLDSKENEKLQELKKEKEDVVKRLERSENELVQRRQRVRDLISYMQHQLKFSTMDMQQDVNSLLRSYVKAIERNSPIVRSQTLKLKQPQTIPKRRRR-MFQAQDMKG----MLQAYLGLMDLRRYWVHMNLHANNHAVIAVNKEKR-------QIQHTSYYKRNLQIS-EIYNLSVLGYPAIHSGKHYWEVDVSRKNAWLLGVNDG-LCAQPQLHSITEMSFSAKYNSC-----------VEQHGNYQPKYGYWVIGMKNR---SASDECFVSHNSS--VSTLSLPCPPTRVGVFLDREACTLSFYDVSNFGGLIYRFHNPFFPDTLYPYFNPMECSEPMTVCRPPSSNSVGR----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3YVI9-1", "uniprot_id": "D3YVI9_MOUSE", "id": "D3YVI9-1", "name": "", "aln": "MMASSALAMAKEEVTCPICLELLKEPVSTDCGHSFCQTCIILNYVSNRRMDGVGSCPVCRVGYLFENLRPNQNMINIVKRIKELKSIPEEKEKVFYCAQHGEKLKLFCKEDRMAICWVCERSQKHRGHQTALIEEVDQEYKEKLQAALKKLMENEKRCDKWQDDLQQQRADWENQIQRDVEYVQMELKGLRDLLDSKENEGLQELKKEKEEVMEKLEESENELREQTELVRDLISDVGHQLALSTMEMLQGMNSVLT-------------RIQVLRLKQPQTIPPKRRR-TYQVQDQVQDLNVMLQAIQGLMYVRRYWVHVTLYANNHAVIAINKEKR-------QIQHTSYYKRNLQIS-KTYNLGVLGYPAICSGKHYWEVDVSRKKTWILGLNDG-LCVQPQLHSISEMGFKVKYNSS-----------VKQCGNYQHKYGYWVIGMKNWSVYNASDECSVTHNSS--VLALSLSGPPSRVGVFLDREACTLSFYDVSNFGALIYRFYEPFFPHTVYPYFNPMECSEPMTVCGPSSSISVETQSKE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "E9PWL0-1", "uniprot_id": "E9PWL0_MOUSE", "id": "E9PWL0-1", "name": "", "aln": "-MASSVLEMIKEEVTCPICLELLKESVSADCNHSFCRACITLHYESNRNPEGEGNCPVCRVPYLFENLRPNRHVANIVERLKGFKSIPEEEQKVNACVEHGEKLQLFCKEDMMAICWLCKQSQEHSGHQTALIEEVNHEYKEKLQAALQKLMENEKRCDEWQDDLQQQRADWENQIHSDIEDIQIEFNGLRDLLDSKENEKLQELKKEKEEVMEKLEESEHELREQRELVRDLISYVQHQLELSVMEMKQGVNYVLT-------------SIQTMTLKQPQIVPPKRRRGTSKAPHLKG----MLQSFEGLMDVQQYWVHMTLHARNNAVIAINKEKR-------QIQYRSYN--TVPVS-EIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDG-KCAQPQLHSKEEMGIKKKYHSH-----------IKQNVTFQPKCGYWVIGMKNSSVYNAFDECSITHNSS--VLALSLPDRPSRVGVFLDQEVCTLSFYDVSNSGALIYRFYDPSFPVEVYPYFNPMECSEPMTVCGPPS----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P15533-1", "uniprot_id": "TR30A_MOUSE", "id": "P15533-1", "name": "Tripartite motif-containing protein 30A", "aln": "-MASSVLEMIKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNTDGKGNCPVCRVPYPFGNLRPNLHVANIVERLKGFKSIPEEEQKVNICAQHGEKLRLFCRKDMMVICWLCERSQEHRGHQTALIEEVDQEYKEKLQGALWKLMKKAKICDEWQDDLQLQRVDWENQIQINVENVQRQFKGLRDLLDSKENEELQKLKKEKKEVMEKLEESENELEDQTELVRDLISDVEHHLELSTLEMLQGANCVLR-------------RSQSLSLQQPQTVPQKRKR-TFQAPDLKG----MLQVYQGLMDIQQYWVHMTLHARNNAVIAINKEKR-------QIQYRSYN--TVPVS-EIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDG-KCAQPQLHSKEEMGIKKNLHSQ-----------IKQNVLFQPKCGYWVIGMKNPSVYKAFDECSITHNSS--ILVISLPDRPSRVGVFLDRKAGTLSFYDVSNCGALIYRFYDPAFPVEVYPYFNPMKCSEPMTICGPPS----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C035-1", "uniprot_id": "TRIM5_HUMAN", "id": "Q9C035-1", "name": "Tripartite motif-containing protein 5", "aln": "-MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPE-GQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQGSVMELLQGVDGVIK-------------RTENVTLKKPETFPKNQRR-VFRAPDLKG----MLEVFRELTDVRRYWVDVTVAPNNISCAVISEDKRQVSSPKPQIIYGARGTRYQTFVNFNYCTGILGSQSITSGKHYWEVDVSKKTAWILGVCAG---FQPDAMCN-----------------------IEKNENYQPKYGYWVIGLEEGVKCSAFQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPYLNPRKCGVPMTLCSPSS----------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** : *******:**:*: :.:* **.*:**: *: . . . *****: * *:*** :: :**: :: .* ** ** *..***** *** :: ***:*::**.* **:* * **: :**: :** .* * . : :: : ::: ::. *:.**: : : ::: :*:::: :*.: **:* :*:::::. * .** * :: : : ::* : *:* * :: * : . :::*: .. .:: :. . **: : ::***.:.: * . :. :** *: : .:** : *********:* . :*:**: * * . :.: :* * *:****: .* ::. . . : :*: * ***:*** . *:**::::* * ***:* *. ::**:** .. *:*:* * * ", "identical_positions": 145, "similar_positions": 151, "identity": "26.41%" }, { "cls_id": "homologset.agr.HGNC:16277", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3L4-1", "uniprot_id": "D4A3L4_RAT", "id": "D4A3L4-1", "name": "RING-type E3 ubiquitin transferase", "aln": "---------------------------------------------------------------------------MTSAVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQACIIGNSDNS-VLNPEGKSSCPVCRTVYQPGSLRPNRHLAAIVKRLREVVLGPGKQLEVI--------FCALHGEKLQLFCKEDGKLICWLCERSLEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEKLKALIQEKRESWKSQVEPERHRIQTEFNQLRSILDREEQRELKKLEVEERKGLSVIEKAEGDLIHQSQALKDLISDLEHRCRG-STVELLQDVGDVTKRSEFWTLKKPQALPTKLKSLFRAPDLKKMLRVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAKLSEPSSLEEH-YDCSVLGSQHFSSGKYYWEVDVTKKTAWILGVCSTPVEPMFSFSQYSSKQGAYSRYQPQSGYWVIGLQRKHEYRAYEDSSPSLLLSMTVPPRRIGVFLDYEAGTVSFYNVTNHGLP---IYTFSKYYFPTALCPYFNPCSCVVPMTLRRPTS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGE7-1", "uniprot_id": "TRIM6_MOUSE", "id": "Q8BGE7-1", "name": "Tripartite motif-containing protein 6", "aln": "---------------------------------------------------------------------------MTSTVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQVCIIGNSNNS-VFGQGGRSSCPVCRTSYQPGNLRPNRHLAAIVKRLREVALCPGKQLEVI--------FCALHGEKLQLFCKEDGKLICWLCERSQEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEKLKALIQEKRESWKSQVEPEKRRIQTEFKQLRSILDREEQRELKKLEVEERKGLSIIEKAEGDLIHQSQSLKDLISDLEHRCQG-STVELLQDVGDVTKRSEFWTLRKPQALPTKLKSLFRAPDLRKMLKVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAQLSEPSSLEEH-YDCSVLGSQHFSSGKYYWEVDVSKKTAWILGVCSTPVDPMFSFSQYSSKQGAYSRYQPQCGYWVIGLQCKHEYRAYEDSSPSLLLSMTVPPRRIGIFLDCEAGTVSFYNVTNHGLP---IYTFSKYYFPSALCPYFNPCSCIVPMTLRRPTS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C030-1", "uniprot_id": "TRIM6_HUMAN", "id": "Q9C030-1", "name": "Tripartite motif-containing protein 6", "aln": "---------------------------------------------------------------------------MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRES-VIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAV--------LCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQG-STMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKH-YDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFP---IYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GIM4-1", "uniprot_id": "A0AC58GIM4_DANRE", "id": "A0AC58GIM4-1", "name": "", "aln": "MRRHVQTSLTKSDVMRETPANFQQDQNPETPPILSPSQQESQSRRARRTEQSMSSSLPAQNKMDKQKLRPEIPPRVSKSSAQRLSRDLTCSICLDLFKQPVSLPCDHTFCEACITSYWSGPRVKCQAGSGSCPQCRKVFHGKSYRPNRIVANIVESYCQGMEESGVRLGAVSEPAPTAPLCMRHREELKLYCEEDQELVCLVCGISQDHRAHTLVCVQDAQKRYRASLTTSANALQKELNTALECERETEEEVKKLKDHTADLKQRIEAQFSELHQFLYQEEKLLQVKLKTEERRELIRLDEHKALLSVEISRLRRAVNDIEDKLSEQDPYTLLRSIKGLLQRQPPKFERPTLTPPSLCEGRFAGPLQYRVWKSLKG--SIYPVPSAITFNSKTANPWLSLTSSLTCVRYQTFNSSVQDNPQRFNAALSLMGGQGFTKGRHYWEVEVYSSTVWTVGVARESVTRKGVINTMPAN-----------GFWTLSLSYGVQYMAG--TSPPTLLSLEEPLARIGVYLDYKRGLVSFYNAESMTHLYTFRDTFTETLFPYFNLGFLDKVHENEPLKVFMPKI", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::.. : ::**.***:*:.:*:*: *.*:**:.** . * * *** *:. :: . **** :* **. : .* :* .: :* * *:*:*:*:** :::* :* * :**.* . :::. :.*: : * : *:.* : * : .*: . *.: : **:::*.:*:.:* : *: **: **:: * ::: : * : . *: :.*:* : .. **:.: .: :*. : . : *: .. * .* :: : : .: . :*:*.:*** * *:.. **: : * . :.. *::*.* *:.*::****:* ..*.* :**. .: :. . : *:*.:.*. :* * :**. ***: * *:*::** : * *****. . **:: ** ::: *:.: *. ", "identical_positions": 122, "similar_positions": 165, "identity": "21.14%" }, { "cls_id": "homologset.agr.HGNC:16278", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZNJ9-1", "uniprot_id": "D3ZNJ9_RAT", "id": "D3ZNJ9-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MATVGPRTGPNSGAEALALAAELQGEATCSICLEFFREPVSVECGHSFCRACIMRCWERPGAG-TGTVTRTLPCPLPCPQCREPARPSQLRPNRQLAAVASLLRRFSLPPTVPGESGTPAVAAPAAAARCPQHGEQLKLYCQDDGRAICVVCDRAREHRSHAVLPLEEAVQEAKELLDSRMKALKKVLEDYEAFRSTEERESKELLKQMAAEKEKVGAEFQALRAFLVEQEGRLLSRLEVLSREVTQKQNENLAQLEGDITQLSKLSSQIQETAQKPDIEFLQEFKNTLSKCSSVPSSKPTTVSSEMKNKVWNVSLKSFVLKGLLKKFKEDLQGELEKEEKVELSLDPDTANPRLILSLDLKSVRLGQRAQDLPNHPRRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWAMQLNNGQYWAVTSPERTQLNCGQLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRIWP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q923T7-1", "uniprot_id": "TRIM7_MOUSE", "id": "Q923T7-1", "name": "E3 ubiquitin-protein ligase TRIM7", "aln": "MATVGPRTGPNAGAEALALAAELQGEATCSICLEFFREPVSVECGHSFCRACIMRCWERPGAG-TGTATRTLPCPLPCPQCREPARPSQLRPNRQLAAVVSLLRRFSLPPTAPGERGTPAVPARAAAARCSQHGEQLKLYCQDDGRAICVVCDRAREHRSHAVLPLEEAVQEAKELLDSRLRALKKVLEDYEAFRSTEERESKELLKQMAAEKEKVGAEFQALRAFLVEQEGRLLSRLEVLSREVTQKQNENLAQLEGEITQLSKLSGQIQETAQKPDLDFLQEFKSTLSKCSSVPSSKPTTVSSEMKNKVWNVSLKSFVLKGLLKKFKEDLQGELEKEEKVELTLDPDTANPRLILSLDLKSVRLGQRAQDLPNHPRRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWAMQLNNGQYWAVTSPERTQLNCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRIWP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C029-2", "uniprot_id": "TRIM7_HUMAN", "id": "Q9C029-2", "name": "E3 ubiquitin-protein ligase TRIM7", "aln": "MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWALQLNGGQYWAVTSPERSPLSCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRIWP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*******.:**********************:****************** ********* .*:.**: * *************************.:********.:.*** *: *..* ****** **** :**********************.******:**********:**::.*** *** *.*****::************:**********************.*** *****:********** :********.**********::******.***:**.**..*******************:*****:********:***********:*****************.****:********* ********************************************************:***.***********: *.**:******************************************************", "identical_positions": 446, "similar_positions": 49, "identity": "87.28%" }, { "cls_id": "homologset.agr.HGNC:1628", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P10810-1", "uniprot_id": "CD14_MOUSE", "id": "P10810-1", "name": "Monocyte differentiation antigen CD14", "aln": "MERVLGLLLL--LLVHASPAPPEPCELDEES----CSCNFSDPKPDWSSAFNCLGAADVELYGGGRSLEYLLKRVDTEADLGQFTDIIKSLSLKRLTVRAARIPSRILFGALRVLGISGLQELTLENLEVTGTAPPPLLEATGPDLNILNLRNVSWATRDAWLAELQQWLKPGLKVLSIAQAHSLNFSCEQVRVFPALSTLDLSDNPELGERGLISALCPLKFPTLQVLALRNAGMETPSGVCSALAAARVQLQGLDLSHNSLRDAAG--APSCDWPSQLNSLNLSFTGLKQVPKGLPAKLSVLDLSYNRLDRNPSPDELPQVGNLSLKGNPFLD---SESHSEKFNSGVVTAGAPSSQAVALSGTLALLLGDRLFV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63691-1", "uniprot_id": "CD14_RAT", "id": "Q63691-1", "name": "Monocyte differentiation antigen CD14", "aln": "MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQPNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSARVPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTDTWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISALCPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAG--TPSCDWPSQLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLH---SESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P08571-1", "uniprot_id": "CD14_HUMAN", "id": "P08571-1", "name": "Monocyte differentiation antigen CD14", "aln": "MERASCLLLLLLPLVHVSATTPEPCELDDED--FRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACARSTLSVGVSGTLVLLQGARGFA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: **** ***.*.:.*******::. * ****:*:*:**.** * .* :**::.** .** :*****::*: *::* :::* ::**** :*::*:::*.*:****. * *:*****:*::*** . *:*** *. * ******** :*********************** ***:** .****::******* ***:**::**** ***::* *****:****.:***:***** * :.********* :.. :* * *.* ********:**::********* ***** ***:* * *:***:*..*:* ***** : .:. ***** * * *. :..:****.** * * *.", "identical_positions": 222, "similar_positions": 86, "identity": "58.89%" }, { "cls_id": "homologset.agr.HGNC:16280", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LY63-1", "uniprot_id": "F1LY63_RAT", "id": "F1LY63-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MSESGEMSEFGYIMELLAKGKVTIKNIEKELICPACKELFTHPLILPCQHSVCHKCVKELLLS-LDDSFN-DVASDSSNQSSPRLRLTSPSMDKIDK---INRPGWKRNSLTPRPTMFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDK-ADSYVLEYRKINRDE-------EMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELVLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGITKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDAYFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGG----IQLEETITAKYLEYEEDV-------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80WG7-1", "uniprot_id": "TRI36_MOUSE", "id": "Q80WG7-1", "name": "E3 ubiquitin-protein ligase Trim36", "aln": "MSESEEISEFGYIMELLAKGKVTIKNIEKELICPACKELFTHPLILPCQHSVCHKCVKELLLS-LDDSFN-DVASDSSNQSSPRLRLTSPSMDKIDK---INRPGWKRNSLTPRPTTFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKVLMCPEHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDK-ADSYVLEYRKINRDE-------EMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELILHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGVTKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGG----IQLEEAITAKYLEYEEDV-------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NQ86-1", "uniprot_id": "TRI36_HUMAN", "id": "Q9NQ86-1", "name": "E3 ubiquitin-protein ligase TRIM36", "aln": "MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLT-LDDSFN-DVGSDNSNQSSPRLRLPSPSMDKIDR---INRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDK-ADSYVLEYRKINRDD-------EMS-WNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGG----IQLEEPITAKYLEYQEDM-------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A9A8-1", "uniprot_id": "A0AB13A9A8_DANRE", "id": "A0AB13A9A8-1", "name": "", "aln": "MSDS-EMSEFASLVERLDRGEVPMKSIERELICPICKELFTHPLILPCQHSICHRCVKELLFPNHEDSFSTDAGSESSNPGSPRSRVPSPGLDKLVRSGSICSPGWRRSSVTPRVTSFPCPGCQHDIDLGERGISMLFRNFTLESIVERYRQAARAAVAIMCGVCKPPPQEATKSCMDCKASFCNECFKLHHPWGTPRAQHEYVGPTTNFRPKVLMCPEHEMEKVNMYCEVCRRPVCHLCKLGGSHANHRVTSMSSAYKILKEKLSKSIHYLISKEEQVRTQITALELLMRSTEENGQLAERRANEHFERLQVALQERRAEMLWAVQQCRSRRVERLRAQVEEYQGMLENSGLVGYAQEVLKETDQSCFVQTAKLLHVRIQKATDSLKTFQPAASSSFEEFQLDTSREEILLKELSFGG-VPDAPVLDLSRCRVYNEALLHWRLPEDSVPTDRHLLEFRKLQQDEEEEKEEVERCWRTSESVYGSSTVVCDLDRDARYAFRVKSCRNGVCSAYSPEVTLHTPPAPVFSFLFSDSCGFSAERLQLSRRRASVESVAGMSVLLAAERVQTGSYTCLDYIIGDTGISQGRHYWAFRVDPASYLVKVGVASDCKLADWFHGPRDSSSPRFDQDSGHDSGSEDVCVDVCQPFLLLTVGMGRLFVPKPP----APESRVLPLPARIGVCLDYEAGRVSFYDGDSLRCPCVRPVECSGEHVSSIRPDGGAEPYTWRSQSQPSGSHTCEEESDCVCVCVCACACACVSVRASQ", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:* *:***. ::* : :*:*.:*.**:***** ****************:**:******:. :***. *..*:.** .*** *:.**.:**: : * ***:*.*:*** * ******:**:******:. ********:************.****.:*******:*******.**:******::***** :***************:******* *::*****:*************.*:*****:****** *******.*.:**.**.**::**: *:***:.** **: *:..* ***:* *::*::.:* *:: .:. *::::::*:*****:***.*********************** **:******:***:*:***.:***:: :: *:: :* **** . * * :: .:.:***:**:.*: **.. :* ::**:**:::*: * .. .* *:*.:: :*: .: *****:: :..:**. * *: *************.:.**:. *:* *. :* *** **:.:******:*.* **.*******.*:::*:*:** **:* **********. ** :*::.***: ***::***********. .* .*** *:*:** ::*:**.* **.****:*: **: ** : *:*.*** * ::* * *:** .:: *.. . .:. :: * :.* ", "identical_positions": 422, "similar_positions": 203, "identity": "55.16%" }, { "cls_id": "homologset.agr.HGNC:16281", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1H278-1", "uniprot_id": "TRI11_RAT", "id": "B1H278-1", "name": "E3 ubiquitin-protein ligase TRIM11", "aln": "--------------------------------------------------------------------------MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQP-----EGPYACPECREVSAQRNLRPNRPLAKMAEMARRLHPPSPVPQG----------VCAAHREPLTTFCGDDLSLLCPTCERS-EHWAHRVRPLQEAADDLKGRLEKSLEHLRKQMEDAMLFQAQAEETCALWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQKLEEEELEVLPRLREGAARLGQQSTQLAALVSELESRCQLP-ALGLLQDIKDALCRVQDVKLQPPAVVPMELRTVCRVPGLVETLRRFRG-------DITLDPDTANPELVLSEDRRSVQRGEQRQALPDSPERFDPGPCVLGQERITSGRHYWEVEVGDQTSWALGVCKETVNRKEKGELSAGNGFWILVFLG---SFYNSNERAFSPLRDPPKRVGIFLDYEAGHLSFYSATDGSLLFIFPETPFSGTLRPLFSPLSSSPTPMTICRLIGVSGDTLGPQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PQ2-1", "uniprot_id": "TRI11_MOUSE", "id": "Q99PQ2-1", "name": "E3 ubiquitin-protein ligase TRIM11", "aln": "--------------------------------------------------------------------------MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQP-----EGPYACPECRELSAQRNLRPNRPLAKMAEMARRLHPPSPVPQG----------VCAAHREPLTTFCGDDLSLLCPICERS-EHWTHRVRPLQEAADDLKGRLEKSLEHLRKQMEDAMLFQAQAEETCALWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQKLEEEELEVLPRLREGAARLGQQSTQLAALISELESRCQLP-ALGLLQDIKDALCRVQDVKLQPPAVVPMELRTVCRVPGLVETLRRFRG-------DITLDPDTANPELVLSEDRRSVQRGEQRQALPDNPERFDPGPCVLGQERITSGRHYWEVEVGDQTSWALGVCKETANRKEKGELSAGNGFWILVFLG---SFYNSNEPAFSPLRDPPKRVGIFLDYEAGHLSFYSATDGSLLFIFPETLFSGTLRPLFSPLSSSPTPMTICRLIGVSGDTLGPQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96F44-1", "uniprot_id": "TRI11_HUMAN", "id": "Q96F44-1", "name": "E3 ubiquitin-protein ligase TRIM11", "aln": "--------------------------------------------------------------------------MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQP-----EGPYACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQG----------VCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLP-ALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRG-------DVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCRENVNRKEKGELSAGNGFWILVFLG---SYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GIM4-1", "uniprot_id": "A0AC58GIM4_DANRE", "id": "A0AC58GIM4-1", "name": "", "aln": "MRRHVQTSLTKSDVMRETPANFQQDQNPETPPILSPSQQESQSRRARRTEQSMSSSLPAQNKMDKQKLRPEIPPRVSKSSAQRLSRDLTCSICLDLFKQPVSLPCDHTFCEACITSYWSGPRVKCQAGSGSCPQCRKVFHGKSYRPNRIVANIVESYCQGMEESGVRLGAVSEPAPTAPLCMRHREELKLYCEEDQELVCLVCGISQDHRAHTLVCVQDAQKRYRASLTTSANALQKELNTALECERETEEEVKKLKDHTADLKQRIEAQFSELHQFLYQEEKLLQVKLKTEERRELIRLDEHKALLSVEISRLRRAVNDIEDKLSEQDPYTLLRSIKGLLQRQPPKFERPTLTPPSLCEGRFAGPLQYRVWKSLKGSIYPVPSAITFNSKTANPWLSLTSSLTCVRYQTFNSSVQDNPQRFNAALSLMGGQGFTKGRHYWEVEVYSSTVWTVGVARESVTRKGVINTMPANGFWTLSLSYGVQYMAGTSPPTLLSLEEPLARIGVYLDYKRGLVSFYNAESMTHLYTFRDT-FTETLFPYFN--LGFLDKVHENEPLKVFMPKI---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: . : .*..: **:**** *.:** *.*.**. ** *. * *. :**:**:: :. **** :*::.* : * * * :* *** * :* :: *:* * * :* :* : :*:* . :. * .* : *:*::: *: : :::* :. . . :*.: .:*..*:::* :**: * :*: ** . * ** * * *. : ::* : ::*.: . . **:.**. * * :*. . * . * .. : ::* :*::..**** * *:.. .*: ..:: *.*:**:.. .::* : :*.********* . * *::**.:*...** : ..**** * : .:. :: .*.:* *:*::***: * :***.* . : *: * : *: ** * *. . : . .: ", "identical_positions": 134, "similar_positions": 155, "identity": "23.59%" }, { "cls_id": "homologset.agr.HGNC:16283", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BVW3-1", "uniprot_id": "TRI14_MOUSE", "id": "Q8BVW3-1", "name": "Tripartite motif-containing protein 14", "aln": "MASETTEARAPFQPD--GAYGWRCPEHSERPAELFCRRCGRCVCALCPVLGAHRGHPVGLAEEEAVRVQKLIQDCLECLATKKRQHADNIAHLEDAGERLKVYADSSKAWLTQKFTELRLLLDEEEVLAKKFIDKSTQLTLQVYREQAETCGKQIEVMDDFSTRVWGIGQEPNPVQLLQAYIATKTEMGQQMSPSELSHPVPLSFEPVKNFFKEFVEAIGNTLQTPMDTRLKENINCQLSNSSSTKPGALLKTSPSPERALFLKYARTPTLDPDTMHARLRLSPDGLTVRCSLLGRLGPRPAPRFDALRQVLGRDGFAAGRHYWEVDVQEAGVGWWVGAAYPSLRRRGASAAARLGCNRESWCVKRYDLEYWAFHDGQRSRLRPRRDPHRLGVFLDYEAGILAFYDVAGGMSHLHTFHAAFQEPLYPALRLWEGPISIPRLP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14142-1", "uniprot_id": "TRI14_HUMAN", "id": "Q14142-1", "name": "Tripartite motif-containing protein 14", "aln": "MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. :* :*:* :.: . *******.:* ******** ********************* * **:**** *:**: ** **:** ***:::*** *:**. *:***:**. *************.********.************::* :*:::*:*:*.***.*.***:*** **** **: ** **** .**.***********.*** :***: .*****:* ****.******:.******:**********:*:*********************.* *****.*** *** *. ***** ***.** **:*************.********.*****************:***:********************* * .***********:******:*********:*:**************.*******", "identical_positions": 342, "similar_positions": 65, "identity": "77.38%" }, { "cls_id": "homologset.agr.HGNC:16284", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JTL1-1", "uniprot_id": "A0A0G2JTL1_RAT", "id": "A0A0G2JTL1-1", "name": "", "aln": "MPLTRSLRGPHQV-ACTVCTRPLQDAVTIACGHAVCLLCLPR-APMGAQ-----LLCPLCQGAEEEKIQTAVTPVSLGPLSETCCEEHGEKIYFFCKTDAELLCVFCREGPAHQAHTVGFLDEAIQPYRDRLRSRLEALRMERDKIEDRKCQEDQKLQEVLMQVESKKQQVEAAFERLKRELVDQRCLLLTRLEELEQQIWKEREEYITTVSQEVDRLGAQVEELEEKCQQPASELLQDARLNQSRYEMKTFVCPEAISSDLIKKIRNLHRKILCLPKMMRTFSENLMHHLETDS-------ETEA-----------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "G3UY57-1", "uniprot_id": "G3UY57_MOUSE", "id": "G3UY57-1", "name": "", "aln": "MPSTRSLRGLHQV-ACPVCTRPLQDAVTTACGHTVCLLCLPR-TPMGAQ-----LLCPLCQGAEEEKIQAAVAPVSLGPLSETYCEEHGEKIYFFCKTDAELLCVFCREGPAHQAHTVGFLDEAIQPYRDRLRSRLEALRMERDKIEDRKCQEDQKLQEVLMQVESKKHQVEAAFERLKRELVDQRCLLLNRLEELERQICKEREEYISKVSQEVDRLSTQVEELEEKCQQPASELLQDARLNQSRYELKTFVSPEAISSDLVKKIRNLHRKILSLPKMMRTFSENLMQHLETDS-------ETEA-----------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C019-1", "uniprot_id": "TRI15_HUMAN", "id": "Q9C019-1", "name": "E3 ubiquitin-protein ligase TRIM15", "aln": "MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQ--EEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * **: *:: **.:*: **:**** .***:.* **** : **** ******* ***: ::.::**.****.** ************:.***:*********:*************************** ***:*** ********* :* *:****:***:*****::** :****** **.***:** ***:***:.**:** **.:**:****************.*:**** *:****.*****.**:****::***** **:*** ***** :*** ** :* : ", "identical_positions": 212, "similar_positions": 52, "identity": "45.4%" }, { "cls_id": "homologset.agr.HGNC:16285", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8N7UV72-1", "uniprot_id": "A0A8N7UV72_DANRE", "id": "A0A8N7UV72-1", "name": "", "aln": "--------MASLNV-SEDLSCPVCCEIFKNPVVLSCSHSVCKECLQQYWRTKTTQECPVCRRRSSKGEPPVNLALKNLCELFLKERNERC---SSASEEICSLHSEKLKLFCLEDKQPVCVMCVTLQQHDNHKFRPISEVASSYKEELNTALKSLQVKLKRNEERKAEFEKTVQHIKSQADHTERQVKHEFEKLHQFLRDEEEATITALREEEEQKKQMMKEKLEEMNTHISALSHTIKDTEEMLKAKDVCFLKEFPVSMERVQISQPDPQTPSGALIHVAGYLGNLTYRVWKKMQDIVHYTPVILDPNTAHPGLILSDDLTTLRNRRN-TQPSPDNPERFDQMYCVLGSEGFISGKHCWDVEVKESLYWNFGVT-------------TASNQRKG--FFS--TGVWSVRCE-------------------------------------------------------------------------LSFGSGFIVKQSLERVRVDLDCDRGTVSFSDPLKNTHLHTFTTTFTESVFPYFYF-------NDIVNCLKILPC--------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1QHK9-1", "uniprot_id": "A0A8M1QHK9_DANRE", "id": "A0A8M1QHK9-1", "name": "", "aln": "--------MASL---SDDFSCPVCCEIFKDPVFLSCSHSFCKECLQQYWSIMETEECPVCRRKSSRDDPPINLVLRNLCELFLKEKNERC---SSVSEEICSLHGEKLKLFCLEDKQPVCVMCVTLQQHENHKFKPIDEAIPMCKEEFNAAVTSLKCKLKRREKMKGQLEETLQHIKTQAERTERQIKHEFESLHQFLRDEEEATITALREEEEQKKQMMKEKLEEMNTHISALSHTIKDSEEMLKANDVCFLKEFPVSMERVQISQPDPQTPSGALINVSCYLGNLPFRVWKKMQEIVYYTPVILDPNTANSSLVLSDDLTSVARDII-IELRPDNPERFDSYCCVLGSEGFTSGTHYWDVEVNESPGWSLGVT-------------TASKQRKGRVFFN--TDFWGVQCG-------------------------------------------------------------------------PFQLPGVQVQKDLKYVRVDLDCDSGTVSFSDPVTNTHLHTFTSTLTESVFPFFCS-------YFTLRILPLGSIQMLEE---------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB13A8Y3-1", "uniprot_id": "A0AB13A8Y3_DANRE", "id": "A0AB13A8Y3-1", "name": "", "aln": "------------------------------------------------------------------MDP------------------------VAVGDPACALHSEKLQLFCLEDKQLACLVCRDSEKHVSHTFRPIAEAVSSYKEELKTTLKSLQFKLTQELKTRGELEKTVQHIKSQADHTLHQIQHEFKKLHQFLRDEEEATITALREEEEQKKQKMKEKLEEMNTHISALSQTIKNTEEMLKANDVCFLKEFPVSMERVQISQPDPQTPSGALIHVSRYLGNLPFRVWKKMQDIVHYTPVILDPNTANPHLVLSDDLTSLRDSFLNSKPLPDNPERFDYYSCVLGSEGLNSGKHRWDVEVKKCSIWSLGLT-------------TASNQRKGRDFFN--TGVWCVSFG-------------------------------------------------------------------------LYEPSGFIVKQSLERVRVDLDCDRGTVSFSDPVTNTHLHTFTTTLTESVFPFFCS-------IYQLRILPFRS---------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1NGD4-1", "uniprot_id": "A0A8M1NGD4_DANRE", "id": "A0A8M1NGD4-1", "name": "", "aln": "--------MASLSE--ENFSCPICHEIFKDPVVLSCSHSFCRECLQQYWRAVDIQECPVCRRRSSRDDPPNNLVLKNLCESFLKERKEKP---SPGSEEICSLHGEKLKLFCLEDKQPVCLVCRDSEQHDNHKFRPIGEVVSSHKEELNTGLKSLQEKLRHKETIKEEFEKTVQHITAQADHSEHQIKQEFEKLHQFLKDREKGTITALRKEEKQKKQMMKEKLEEINTHISALSDSIRDTKEMLKANDVCFLKEFPGSMERVQISQPDPQTPSGALIHVSQYLGNLQYRVWRKMEDIVHYTPVILDPNTANSHIVLSEDLTSVRESEN-KQWLPDNPERFD-YPCVLGSVGFCSGKHRWDVEVKESRCWSVGVT-------------TASNQRKRDVFFN--TDVWSVWH-------------------------------------------------------------DPYG-------LIKSSSNEFPVEQYLECVRVELDYDRGTVCFSDPVNNTHLHTFTTTFTDAVFPFLWCDL-----FSSLRILPFNR---------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TMD8-1", "uniprot_id": "A0AB32TMD8_DANRE", "id": "A0AB32TMD8-1", "name": "", "aln": "--------MASLKVSVEDISCSVCCEIFKDPVVLSCSHSFCRECLQQFWRTKGTQECVVCRRRSSRDDPPNNLVLRNLCESFHQERKEKR---SSGSEEMCSLHGEKLKLFCLKDKQPVCLVCVTSQQHDNHKFRPIGEVVPAYKEELYTALKTTQKKFEQNEEMKVEFEKTVQHITAQADDTEHQIKQQFEKLHQFLRDEEAATITALREEEEQKKQMMKEKLEEINTHNSALSDSIRDTKEMLEANDVCFLKEFAGSMERVQISQPDPQTPSGALIHVSQYLGNLQYRVWKKMQDVVHYTPVILDPNTAHPILVVSDDLTSVRETDV-EHLFPDNPERFDWFPCVLGSEGFSSGKHSWDVEVKERRWWSVGVT-------------TESNQRKGKVFFN--TDVWSVRYREDNQNVDDDDDADEEKDEDDDDDDEDDDDDDDDDDDDEDEDDDEEKDNEDDDDDDDDDDDDEDGDDDEDSSPNLSVSTSFNIEQDLECVRVELDYDRGTVCFSDPVTDTHLHTFTTTFTDTVFPFFTS-------LDPLRILPVKDQ--------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0ACD6B6D8-1", "uniprot_id": "A0ACD6B6D8_DANRE", "id": "A0ACD6B6D8-1", "name": "", "aln": "--------MSSLSE--EDLSCPVCREVFKNPVILSCSHSFCRECLQHFWRTKGTQQCAVCRR-ISAHEPLCNLVLKNVCESFIK--KEKP-------EEICSLHNKKLKLFCLEDKQPVCLVCVTSHQHDQHTFRHIEEVLQAYKEELNKALTSLQEKLKHSKKLKGEFKRTVQHITAQADDTERQIKHQFEKLHQFLRDEEEATITALREEEEQKKQMMKEKLEEINTHISALSHTIRDTEEMLKANDVCFLKEFAGSMERVRISQPDPQTPSGALIHVSQYLGNLQYRVWRKMQDIVHYTPVILDPNTAHPHLIVSDDLTSVRLTED-KHPLPDNPERFDYFECVLGSVGFSSGKHRWDVEVKDNDEWTVGVT-------------TAS-KRKGEDFYD--SDIWSVEN-------------------------------------------------------------VEYFANTPQDSPNSSASNCFHVKQDLEFVRVELDCDEGTVCFSDPVTNTHLHTFTATFTDSVFPFFTS-------LDPLRILPVKVSEHFTCNSGSSSFRHVSSCCPRLMSDQVTDVLL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1Q7P5-1", "uniprot_id": "A0A8M1Q7P5_DANRE", "id": "A0A8M1Q7P5-1", "name": "", "aln": "--------MASSAE--YDYSCPVCHDIFKTPVILSCTHSFCKECLQQFWRSKNTQECPVCRRRSSKKDLPVNLALKNLCESFLKERNERR---SSGSEEICSLHSEKLKLFCLEDKQPVCLVCRDSEKHLGHTFRPLSEMAAENMEELNTALKSLQEKLKHNENIKEEFEKSVQHIKAQAEHTERQIKQQFKKLHQFLRDEEEATITALREEEEQKKQMMKEKLEEMNTHISALSHTIKDTEEMLKANDVCFLKEFPVSMERVQISQPDPQMPSGALIHVSRYLGNLPFRVWKKMQDIVQYTPVILDPNTAYPEFVVSDDLTSVTFSEN-KQPVPDNPERFDYYPFVLGSEGFNSGKHCWDVEVNRSFEWRVGVT-------------TASNQRKGQVFLN--SDVWSVYYY------------------------------------------------------------------------AHGLLATGFCGSDLDRVRVDLDYDRGTVSFSDPVNNEHLHTYTTTFTDTVFPFIYC-W-----RSSLRILPFSSQ--------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1PZW6-1", "uniprot_id": "A0A8M1PZW6_DANRE", "id": "A0A8M1PZW6-1", "name": "", "aln": "--------MSSQAE--YDYICPVCHEVFRVPVILPCGHSFCQRCVRQFWSGRRARECPVCRRSCRHLQPVVNLALKNLCEEFETRRKR------SRPEDMCGLHQEKLKLFCLQDNQPVCVVCFTSQQHDQHTLRPVAEAAAPRKDQLSAALKILQEKLQHREKTKEELQKTLQHIRAQAEQTERQIRLQFQKLHQFLRDEEEASVSAVREEEEEKQQMMKEKLEDINKHISDLSHAIRDTEESMSRSSIRFLQEFTVSMERVQISPPDPQIPAGALINESRHLGNLMHRVWRKMENIVQHTPVVLDPNTAHPDLLVSADLSSVRWSWS-KRALPDNAERFDHHPCVLASEGVRSGTLSWAVEVRQSSDWTLGVT-------------TELNQRKGWDFFS--ADVWSVCYDEYS--------------------------------------------------------------------VSERPVFGVRVKQRLERVRVDLDYDGGTISFSDAVNNTHIHTFSSNFTHTLIPFFSCYT-----IFNLKILPSNSQQQLNTNAELTP---------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7TBF6-1", "uniprot_id": "A0A8N7TBF6_DANRE", "id": "A0A8N7TBF6-1", "name": "", "aln": "-------MATKQSHLAEDLSCPICGSILQKPVVLFCRHRFCKPCLESLWNGGGSCECPLCCQPSSMGELVVNTVLEKTCEGFLEKCKN--------DPLACREHGETLTLFCLEHLEPTCSKCKSSMNHQGHRLYPLNEASHDCKEELKNALKPLQEKLKLFRKVKLTCEHAVNHIKNQAENTERQIREEFEALHQFLRDEEASRLSMLKQEREQKRQMMNEKIEDLENDITSLTNTIRIIEQEMRSQDIPFLKNYKDTIKRTWRIPQDPEMIAGSLLDIAKHLGSLKFKVWERMLEIIQYTPVTLDPNTAASCFLLSEDLTTLQCCSQ-TFKLPENPERFNVGAEVLGYEGFSSGRHSWDVEVKNNTYWVIGVA-------------SASISRKGKHVLTPAEGFWTIRLRNGE------------------------------------------------------------------YKACTAPWSPLTMTKEPQVVRVVLDMNRSRVTFYDLRERTPLFTYTDIITPRAFPYFCSACK----EYPLKVLPAWISIKSE----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q5RKG6-1", "uniprot_id": "TRI35_RAT", "id": "Q5RKG6-1", "name": "E3 ubiquitin-protein ligase TRIM35", "aln": "MEPGPSVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPRPCRAHRAPLTLFCVEDKELLCCACQADARHQEHRVQPIKDTAQDFRAKCKNMEHVLREKAKSFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQATVDAMKEESRKKHLLAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKRRLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVADDLTSVINHGY--RVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPSWRVGVVRVQAHAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDG---------------------------------------------------------------DHCMTSDTATAPLVQAMPRRLRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRVSIKEELDI-------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C006-1", "uniprot_id": "TRI35_MOUSE", "id": "Q8C006-1", "name": "E3 ubiquitin-protein ligase TRIM35", "aln": "MEPGPSVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPRPCRAHRAPLTLFCLEDKELLCCACQADARHQEHRVQPIKDTAQDFRAKCKNMEHVLREKAKAFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQATLDAMKEESRKKHLQAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKRRLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVADDLTSVINHGY--RVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPTWRVGVVRVQAHAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDG---------------------------------------------------------------DHCMTSDTATAPLVQAMPRRLRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRVSIKEELDI-------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPQ4-1", "uniprot_id": "TRI35_HUMAN", "id": "Q9UPQ4-1", "name": "E3 ubiquitin-protein ligase TRIM35", "aln": "MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGY--RVQVENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQ--------DSGAEGHSHSCYHDTRSGFWYVCRTQGVEG---------------------------------------------------------------DHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRICPLHISVKEELDG-------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * * * ***::. : * * .* * . : : : : * : : :* :: ::: :*. *::**: .* . : : :* .:*: .**:::: . *: *. : : ..: ** :. .* .* *:. . :* .* .:**.:* : .*. :***** : :: **::: :*.***. :*. . .* * * : * .*:. :. ..* : :** *: : . : * * :.*: : : :. ", "identical_positions": 58, "similar_positions": 96, "identity": "9.81%" }, { "cls_id": "homologset.agr.HGNC:16286", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BPU7-1", "uniprot_id": "ELMO1_MOUSE", "id": "Q8BPU7-1", "name": "Engulfment and cell motility protein 1", "aln": "MPPP------SDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSN-FYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLAS-LSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKK-IASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGTDQ-EIQTYTIAVINALFLKAPDERRQEMANILAQKQLRYIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKR-------KSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRP--ILELKEKIQPEILELIKQQ-RLNRLVEGTCFRK-LNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYD--SNCQLNFIAPDKHEYCIWTDGLNAL--LGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92556-1", "uniprot_id": "ELMO1_HUMAN", "id": "Q92556-1", "name": "Engulfment and cell motility protein 1", "aln": "MPPP------ADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSN-FYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLAS-LSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKK-IASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQ-EIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKR-------KSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRP--ILELKEKIQPEILELIKQQ-RLNRLVEGTCFRK-LNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYD--SNCQLNFIAPDKHEYCIWTDGLNAL--LGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VKB2-1", "uniprot_id": "Q9VKB2_DROME", "id": "Q9VKB2-1", "name": "", "aln": "MIPKKTTVKDSHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTS-LSTDHTFALEFIKEKGLDTLIKMIEDGGQ-----------TNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLENIVMCSN-KHVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRTIAQTISAKQFRLALIG------NGLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQ-RLSFLVEGTHFAKYLRGTRTKDKFWYARLSPNHKVIHYGDCDEKTIP--TMEELPKKLPISEIKQLLEGKECPHMKET---RIRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINAL--LGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGVDISKDPPPIPEDPENYDFCFES-------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07799-1", "uniprot_id": "LMO1_YEAST", "id": "Q07799-1", "name": "ELMO family protein LMO1", "aln": "-------------MKHNRQMPDESLENIKVLLNPKLGKPVKSLTS--AQSKACYHTLISNKNLN--KTSDEYEKLLANYILLCDEKYLCKTVIPDSRFWAILCDNCQKLRSETLVANLIRIFNVALKCQDSNKNEVIVSICHISRE----------------NSQLIGILLQLLSQRPIHIPLFTDTILCITLFLKCSLTLCETSLSHAVEFVPRILILLFQYNFPASMSELLYIEDLQPLILEEFVPLKQRLINFLSSVSIDDYSCSLK--ADLLTAIKDNSVFQK-------GLEMEMG------DLPSINLLNAYDTFTFLNSPNGSFKRLYTEQLLFGENDFPLYEAIFKLSDQ----------FRRLFNLSGKKENQYSDSERDLKLQIATAVLNRQTCFYKTLELFLRFWIESLAKSQSDLVSLLNLAIITLKYVCLSSSDLEAAIQTKSLLKTQVVALDS-MRYKFARTLQLDSIKKEQYRTWSSSIASFDTMLSGQVR-----------DYVRHQRLLQLQKGTWVYAENPLNPEAGTPKVYFLIVSDNHANLLAREFETQTNDLPYLFDNKILTSPGSEALANG---RTKVVVLKHITSFKSIELTTPSRRTSSNVYIKLDEANVYTGVELKDRN--------------------------DRTVLKFYLDTEEGRYIWLDGLKLISPFQHEDISEDTKEQIDTLFDLRKNVQMINLNVRQDIIVPPPEPSDEDEDEEFYNLETLKKVTQNFYFD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* : . : ::: . *. ::.: . : :. .:* . * ::: .: : * :* .:.. . . : : : *.: * ..* : . . . : .: . . : . : :::*:.: : ::: : . . . . ::: : . .:: : : * : :: * .:.:: :. . : *: :: : . : .: ** : ::.**: .: . : . : : : : : : . : : : :: * . . : . *: : : : :: *. .: :.. .: . :* * :* * . : . ::. ..: * :. *. : . . :: *: :..: . :: *: :: : * : : .: . * . :: .:: . *: .* * *.:.. : . :. :: ::: : . : .. . ..: ** ::: : *: .. *.* : * **:: : : : :*. ..:::***:.:. :::::: : : *** *.: .: : :: ", "identical_positions": 50, "similar_positions": 245, "identity": "6.54%" }, { "cls_id": "homologset.agr.HGNC:16287", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZA85-1", "uniprot_id": "D3ZA85_RAT", "id": "D3ZA85-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "-----MAAAERAWG-----AAVGVARLCRRLCHVAT--PHAFK---KQPLHQYVQRPLFPLRTPLYNTVRFMFIQTQDTPNPNSLKFIPGK-PVLETR-TMDFPTPAAAF----RSPLARQLFR-IEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPP--GEAGSS------------EEDDEVVAMIKELLDTRIRPTVQEDGGDVIYRGFED--GIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQVMDDEESDEKEANSP-------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZ23-1", "uniprot_id": "NFU1_MOUSE", "id": "Q9QZ23-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "-----MAAAERAWG-----AAVGVVRLCRRFCHVAT--PHTFK---KQPLHQYVRRPLFPLRAPLCNTVRFMFIQTQDTPNPNSLKFIPGK-PVLETR-TMDFPTPAAAF----RSPLARQLFR-IEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPPPPGEAGS-------------EEDDEVVAMIKELLDTRIRPTVQEDGGDVIYRGFED--GIVRLKLQGSCTSCPSSIITLKSGIQNMLQFYIPEVEGVEQVMDDDESDEKEANSS-------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UMS0-1", "uniprot_id": "NFU1_HUMAN", "id": "Q9UMS0-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "----MAATARRGWG-----AAAVAAGLRRRFCHMLKN-PYTIK---KQPLHQFVQRPLFPLPAAFYHPVRYMFIQTQDTPNPNSLKFIPGK-PVLETR-TMDFPTPAAAF----RSPLARQLFR-IEGVKSVFFGPDFITVTKENEELDWNLLKPDIYATIMDFFASGLPLVTEETPS--GEAGS-------------EEDDEVVAMIKELLDTRIRPTVQEDGGDVIYKGFED--GIVQLKLQGSCTSCPSSIITLKNGIQNMLQFYIPEVEGVEQVMDD-ESDEKEANSP-------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G6J7-1", "uniprot_id": "A0AC58G6J7_DANRE", "id": "A0AC58G6J7-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "--MPIQDVTSRSLGALTSMAAYRSVGFGRNLAAVLKR-TYHGSGLIRPPVYTMGRSPVPQQTTTVF--IRNMFIQTQDTPNPNSLKFLPGR-AVLDSG-TMDFAGPRDAF----CSPLARQLFR-IDGVKSVFFGPDFITITKTSGETEWKVIKPDVFATIMDFFTSGLPVINEADAPRADTAPS-------------EDDDEVVAMIKELLDTRIRPTVQEDGGDVLYHGFED--GIVKLKLQGSCTSCPSSIITLKNGIQNMLQFYVPEVEGVEQVKEE---DVEVA----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8SY96-1", "uniprot_id": "NFU1_DROME", "id": "Q8SY96-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "MSKFLSQAALNTLRN----TRLGSRQLVRSFKGISNTRNHRIPAHQESGCGHSVGCGLLELRMPVAC-RRSMFIQTQDTPNPESLKFLPGV-DVLGKGNTYDFPNGTTAH----NSPLAKLLFR-VEGVKGVFFGADFVTISKQEG-AEWSLIKPEVFAVIMDFFASGLPVLNDAQPN--ADTEIL------------EDDDETVMMIKELLDTRIRPTVQEDGGDIVFMGYEG--GVVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVESVEQVFDEADRMIESEFERFEKNLKTLKQQEPSGGGPH", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "B8A6A3-1", "uniprot_id": "B8A6A3_DANRE", "id": "B8A6A3-1", "name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "aln": "------MAASIRWS---------LQRFVR-----SNHLRYPVNDRNQCYSLWAARRIQHQQNEFKSFSVRKLSILTQDTPNPRSLKFLPGK-PVLGTG-TQDFPTSASAE----SSPLARDLFQ-ISGIKSVFYGPDFITLTKTDDDVEWTDIKRHAIEVISKFFEGGEAITTGAAHA---ESSVT------------EDDDEIVSLIKELLDTRIRPTVQEDGGDVIFKGFED--GTVKLKLVGSCTGCPSSTVTLKNGIQNMMQFYIPEVDNVEQVQDEVDEINMKVYTELEKKLQDV-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P32860-1", "uniprot_id": "NFU1_YEAST", "id": "P32860-1", "name": "NifU-like protein, mitochondrial", "aln": "--------------------------------------------------MFKSVAKLGKSPIFYLNSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLINHSKLAQQIFLQCPGVESLMIGDDFLTIN-KDRMVHWNSIKPEIIDLLTKQLAYGEDVISKEFHAVQEEEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGGDIDYRGWDPKTGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQIMDPEQEIALKEFDKLEKKLESSKNTSHEK----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : * * *** .:***:. :* . : .: * **: :* *::.:: * **:*:. . .*. :* . : . : * : . *:*:* :*:**:******:: *****: : *:: * * *:: *:*:.*.** :*** *::.*::.*: **. * *: : ", "identical_positions": 58, "similar_positions": 58, "identity": "18.65%" }, { "cls_id": "homologset.agr.HGNC:16288", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZY8-1", "uniprot_id": "TRIM9_RAT", "id": "Q91ZY8-1", "name": "E3 ubiquitin-protein ligase TRIM9", "aln": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQT-PESESPQSRRASGSG-VSDYDYLDLD--------------------KMSLYSEADSGYGSYGGFASAPTTPCQ--------KSPNGVRVFPPAMPPPP---THLSP----ALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGT--LTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKAS-------SPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVA------------------------------------------------------------------------------------------------WFAFD---PGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTG----------LPVPDFYSSRASIA-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C7M3-1", "uniprot_id": "TRIM9_MOUSE", "id": "Q8C7M3-1", "name": "E3 ubiquitin-protein ligase TRIM9", "aln": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQT-PESESPQSRRASGSG-VSDYDYLDLD--------------------KMSLYSEADSGYGSYGGFASAPTTPCQ--------KSPNGVRVFPPAMPPPP---THLSP----ALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGT--LTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKAS-------SPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFD---PGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVSLWAPGLRACSGCYFKVCPGAVKSPQAPAP----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C026-1", "uniprot_id": "TRIM9_HUMAN", "id": "Q9C026-1", "name": "E3 ubiquitin-protein ligase TRIM9", "aln": "MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQT-PESESPQSHRAAGSG-VSDYDYLDLD--------------------KMSLYSEADSGYGSYGGFASAPTTPCQ--------KSPNGVRVFPPAMPPPA---THLSP----ALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGT--LTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKAS-------SPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVA------------------------------------------------------------------------------------------------WFAFD---PGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTG----------LPVPDFYSSRASIA-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B3Y3-1", "uniprot_id": "A0A8M2B3Y3_DANRE", "id": "A0A8M2B3Y3-1", "name": "", "aln": "MDEMEEELKCPVCGSFFREPIILPCSHNICLACARNILVQT-PDAESPQSSRASGSG-VSDYDYLDLD--------------------KMSLYSEADSGYGSYGGFVSAPTTPCQ--------KSPNGVRVFPPSMPPPQQAQHHLLPHTG-VLPPVPRNSCLTCPQCHRSLTLDDRGLRGFPKNRVLEGVVDRYQQSKAAALKCQLCEKSPREATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRISRRASPRKISTCTEHELENLSMYCVQCKTPVCYQCLEDGKHSTHEVKALGAMWKLHKGQLSQALNVLSDRATEAKEFLVQLRNMVQHIQENGVEFEACLVAQCDALIEALNRRKAQLLSRVTKEHEHKLSVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHMTENQWGKGS--LTPRMSSDFDLTLDSGPLLQTIHQLDFVQMK-----------VPAAPILQLEECCTQTSSATLSWKQPPLSTIAVDGYILELDDGTGGQFREVYVGTEMICTVDGLHFNSTYKSRVKAFNSSGVGQYSKTLVMQTSEIA------------------------------------------------------------------------------------------------WFTFD---SASAHPDIILSNDNLTVTCNSYDDRVVMGNTGFSRGVHYWEMTIDRYDNHPDPAFGVARADVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTDGGISKGATVGVLLDFTRGILLFLINDEQQGPVAFNTLEGMYYPAISLNRNVQVTLHSG----------LPIPDFYTPGESEAAGSVC", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9MRI4-1", "uniprot_id": "TRIM9_DROME", "id": "M9MRI4-1", "name": "E3 ubiquitin-protein ligase TRIM9", "aln": "---MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAR--EALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKP------RGAAQQRESVCGEHEET-LSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPP--NHSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVA------------------------------------------------------------------------------------------------WFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLYGVFYPAVSINRGVTLTMHTA----------MDAPKMDYF----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 283, "similar_positions": 244, "identity": "32.53%" }, { "cls_id": "homologset.agr.HGNC:16289", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZN56-1", "uniprot_id": "D3ZN56_RAT", "id": "D3ZN56-1", "name": "", "aln": "MADPKMASQLQEDVTCPICLEILQDPVTIDCGHNFCLKCINQIGKTS-ENILCPLCKCSVSKNTFRPNKLLASLAEKIQTMDPADIQQEKEEARCQKHKKKLYYFCEQDGALLCVVCRDSKDHKFHDVTLIDEAVQNYKVQIESQAQDLGRKDKEIIEEKKRGEGAIWTFRAQVELEKLKVIEEFKHLRQRLDEEESFLLSRMDWLEKQGAKQLGQYVTVTEKQLNSLRTLTKSLKIRLQSSSIELLKDIKDTLSRNKEFQFLSPIPVPVDLEKKRSEAKARLESVLKSLTEFKDNLKAKGKKDKSEFVSSLNKEERESWSLLQKNNSMSPTPVPMTLDKDSADPDLTISHDGKKVTLYYIAGKASNKQAKPRPFYPFHCVRGSPGLSSGRRVWEAEIWEPSGGACIIGVATELAQGSQSQNIRMQNCIWALRISPTGCQPFTNCKTQEHLQVCLKKVGVYVNHDCGEVIFYDAITSKHIYTFQTSFNGRVFPLFGLQVTCSHITLTP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R0K2-1", "uniprot_id": "TRI31_MOUSE", "id": "Q8R0K2-1", "name": "E3 ubiquitin-protein ligase TRIM31", "aln": "MAGQPLACQLQEEVTCPICMEILQDPVTIDCGHNFCLQCISQVGKTS-EKIQCPLCKLSVNKNTFRPNKLLASLAEKIQSMDPADIQAEKEDSRCQRHKEKLHYFCEQDGAFLCVVCRDSKDHKSHNVTLIDEAAQNYKVQIESQAQDLGQKDKKIIEEKKQGEGAIWAFRAQVDLEKLKIHEEFKLLRQRLDEEESFLLSRLDWLEQQGAKQLRQYVTVTEKQLNSLRKLTKSLKIRLQSSSMELLKDIKDALSRGKEFQFLNPNPVPEDLEKKCSEAKARHESIIKTLTELKDDMNAEGKRDKSAFMNSLNKEEKESWSLLQKNNSVLPTSVPVTLDKSSADPDLTFSQDLKKVTLYIVAGKASNRQAKPRPFYPFHCVRGSPGLSSGRQVWEAEIRGPSGGACIVGVVTELARGAQSQTVSAQSYIWALRISPSGCQPFTNCKAQEYLQVCLKKVGVYVNHDCGEVVFYDAITSKHIYTFQTSFDGKVFPLFGLQVACSHITLSP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZY9-1", "uniprot_id": "TRI31_HUMAN", "id": "Q9BZY9-1", "name": "E3 ubiquitin-protein ligase TRIM31", "aln": "MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSVRKNAIRFNSLLRNLVEKIQALQASEVQSKRKEATCPRHQEMFHYFCEDDGKFLCFVCRESKDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEKQRILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYVASTEPQLNDLKKLVDSLKTKQNMPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKLSEAKSRHDSITGSLKKFKDQLQADRKKDENRFFKSMNKNDMKSWGLLQKNN--------HKMNKTSE-----------------------------------------PGSSS------------AGGRTTSGPPNHHS-SAPSHS--------LFRASSAGKVTFPVCLLASYDEISGQ------GASSQDTKTFDVALSEELHAALSEWLTAIRAWF-CEVPSS------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. :. :***:* ****::***.************:**.*:*:** : ***** ** **::* *.** .*.****:::.:::* ::::: * :*:: ::****:** :**.***:***** *:*:**:**.***: **:.* * * :*:*: :: * :* : .* **: ** :: **: *:* *:**:.*****: ** ::*:: :**: ** ***.*:.*..*** : : .. :**:*** .*.*.:*****.* *** :**** ****:* :*: :*.::**:::*. *:*:. *..*:**:: :**.****** .::* * ** ** :** * .. : .: *:. :* *.:* .*. * .: ::. : . .. :. :*. *:.::: :.: : . * :*..* ", "identical_positions": 182, "similar_positions": 149, "identity": "35.83%" }, { "cls_id": "homologset.agr.HGNC:16290", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M0K4-1", "uniprot_id": "A0ABK0M0K4_RAT", "id": "A0ABK0M0K4-1", "name": "E3 ubiquitin-protein ligase TRIM33", "aln": "MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAPVPVPVPVPVPAPAPAPAPAPAPAPGPSSGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIP-----GGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS-ESVGTSG--QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVG-QVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPVPTTTTTTQQ-------------------------------HPRQAAPQMLQQQPPRLISVQTMQRGNMN--CGAFQAHQMRLAQNAARIP-GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSAHN--PINPTSPTTATMANAN--RGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTN--LHLESELDTLTSLENHVK--TEP--ADISESCK----------QSGLSSLVNGKSPIRNLMHRSARIGGDGN------SKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP--SGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCH-ELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFN-------------------EMMKVVQVYADTQEINLKADSE------VAQAGKAVALYFEDKLS--EIYSDRTFAPLPEFE-QEEDDG-------EVTEDSDEDFIQPRRKRLKSD-ERPVHIK--------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PP7-1", "uniprot_id": "TRI33_MOUSE", "id": "Q99PP7-1", "name": "E3 ubiquitin-protein ligase TRIM33", "aln": "MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAAAPAPAPA--PAPAPAPAPAPAPAPGSSSGPPLGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIP-----GGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS-ESVGTSG--QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVG-QVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPIPTTTATTQQ-------------------------------HPRQAAPQMLQQQPPRLISVQTMQRGNMN--CGAFQAHQMRLAQNAARIP-GIPRHSAPQYSMMQPHLQRQHSNPGHAGPFPVVSAHN--PINPTSPTTATMANAN--RGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTN--LHLESELDTLTGLENHVK--TEP--TDISESCK----------QSGLSNLVNGKSPIRNLMHRSARIGGDGN------SKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP--SGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCH-ELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFN-------------------EMMKVVQVYADTQEINLKGDSE------VAKAGKAVALYFEDKLS--EIYSDRTFTPLPEFE-QDEDDG-------EVTEDSDEDFIQPRRKRLKSD-ERPVHIK--------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPN9-1", "uniprot_id": "TRI33_HUMAN", "id": "Q9UPN9-1", "name": "E3 ubiquitin-protein ligase TRIM33", "aln": "MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVST------------------PAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIP-----GGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS-ESVGASG--QRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVG-QVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQ-------------------------------HPRQAAPQMLQQQPPRLISVQTMQRGNMN--CGAFQAHQMRLAQNAARIP-GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNT-TINPTSPTTATMANAN--RGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTN--LHLESELDALASLENHVK--IEP--ADMNESCK----------QSGLSSLVNGKSPIRSLMHRSARIGGDGN------NKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP--SGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCH-ELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFN-------------------EMMKVVQVYADTQEINLKADSE------VAQAGKAVALYFEDKLT--EIYSDRTFAPLPEFE-QEEDDG-------EVTEDSDEDFIQPRRKRLKSD-ERPVHIK--------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6E2N3-1", "uniprot_id": "TRI33_DANRE", "id": "Q6E2N3-1", "name": "E3 ubiquitin-protein ligase TRIM33", "aln": "-MEVEASGTEDNGDGGAKEPEAVVSIDTETKEAADEAKSQETVPQTPTTSSDSSSSGGGGEATDGTPNAESADPPPPPPPPPPPPPSTPADSTAAAASP-------------AVLTEMSPPPPASTSSSSSTPAAPINLLDTCAVCKQSLQNR-DCEPKLLPCLHSFCLKCIPQPDRKITMPVQ-----GPHGQDTRIVNVMRCTVCHQDYKQIDMVDNYFVKDTSEATNTSVENSTQVCTSCEDNASAIGFCVECGEWLCKTCIEAHQRVKFTKDHKIRKKEEVSPESVGTSG--QRPVFCPVHKQEALKLFCETCDTLTCRDCQLLEHKEHRYQFLDEACQNQKGIIATFMTKLQEKRGLVEYSASEVQKRLKEVAETHKKVEHEIKIAVFTLINEINKKGKSLLQQLESVTKDRSMKLLSQQRDISVLAQQIIHVLNFTNWAITNGSSTALLYSKRLITYQLRLIMKARVDAVPPANGAVRFFCDPTFWAKNVVNLGNLVIEKVAPTAPPSNMMVNQQISPGHNHPGKHSGQINLAQLRLQHMQQAAIAQKHQQQHQHHQQQQHQHQHQQQQQQQQQQQQQQQQQQQQQQHQQQIQQQMRIASQMSQHPRQGAPQMIQQPPPRLISMQALHRGGVNGSSHMFPPHHLRMVSAQNRMPSAQPRLNGQPYPMMQPQLQRQHSNPGHAGPFPVASLHNISAANPTSPTSASMANAHMHRGPSSPVITPIELIPSVTNPENLPCLPDIPPIQLEDAGSSTLDNILSRYISANAYP--TVGPTNPSPGPSTHSPGSSGLSNSHTPARPSSTSSTGSRGSSGTT------------VDQVKVKQEPGVEEECSYSGANVKTERTKDGRRSACMMSSPEGSLTPPLPILGSVSTGSVQDILRTLGENVK--SEPQSDNLSSCTN----------PNSRATLTNGTSGSNGGQRGGATNANSQTTA----GKEDDPNEDWCAVCQNGGELLCCDHCPKVFHITCHIPTLKSSP--SGDWMCTFCRNLANPEIEYNCDDDPPRNKEKNEMAMSPEEQRRCERLLLHVFCH-ELSTEFQEPVPTSVPNYYKIIKHPMDLTLVKRKLQRKHPLHYKSPKEFVSDVRLVFSNCAKYN-------------------EMSRIIQVYDEEKQSNVQADSE------VAEAGKAVSLYFEERLL--EIFPEQTFPVVMEKETQIEAEK-------EDSDDSDDDIIQPKRKRLKVDTEMLLHIK--------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KGE5-1", "uniprot_id": "A0A0B4KGE5_DROME", "id": "A0A0B4KGE5-1", "name": "", "aln": "-----------------------MDMDLEQLKNDFLPLIAGIKQEQ--------------------LDAVPTDALPQMSTPNTASGAPTTSSLSSSS-----------------LSLSNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSN--DRPKLLECLHVACAQCVSTKFSELDRSLPPLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRAD-IPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPN--GTPQPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVG----MQRHGQPHVSSSTHP--QNMDISLRGLLN-NQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQMR-PHFMPGQQG-FSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAMQNSLGFHG--SQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEGSEKSSSGE-------LSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNTSNSPALLGVNATGSPSPIENGRKSCGSASLGDSDGACLPAKRARRSAHEXNELMPGGKGTDGEQQAETGQERRQEEQQQLPAFLEEMDLEMPQRPHSLGSSVIQESADYVLQLLHAYAAAFGL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . : * .:.. . * .. : ... :: : . .* * . . ... * .*. * * * .. .**** *** * :*:. :: .: . : :: . :: * *. : . : ..* : *:**.*.* * .:**:*.*::*.:*::****:*:**** *: *::.. *.:. :. :: :* :* ** *.******* ******** :*::*:*:* .* :.: : .::::: *: : ::. ::.* : : :.:* : :**. ..: * :*.:**.*: :*:.* ..: *:.::. : *: : * ::* : *: .**. *:* **: :. :*: : * * :* .: .:*: : . :. :.:* * ... . .* :* : . . *:* : * : . ** *:. *:: .. * .:: ** :* .: . * . . : * *::: * **: * *. . . . :.. .: : ::: * .. . :. : : . :*. .:* : *..::*: : * . . . *..* :: . *..*: . . * *:..:. .. *. . . :. :. .. .: ... *:. :.:. .* *.:. : . ::.* ** ... : .. * :* : . .: .. :.*********** :**:*:**::****** .**:*:: * * * .* * :* :: : ..:. : :*. : * :*: * ::*: * * :*:** . : ..**:*:. **.* :: :*: . . **: **:****:*.* : :: : : : : . : *: * :*.. .: : : . : . : . . *.::: :.:* : : : .:: ", "identical_positions": 205, "similar_positions": 373, "identity": "15.89%" }, { "cls_id": "homologset.agr.HGNC:16297", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VC97-1", "uniprot_id": "BUP1_MOUSE", "id": "Q8VC97-1", "name": "Beta-ureidopropionase", "aln": "MAGPEWQSLEQCLEKHLPPDDLAQVKRILYG-KQTRNLDLPREALKAASERNFELKGYAFGAAKEQQRCPQIVRVGLVQNRIPLPTSAPVAEQVSALHKSIEEIAEVAAMCGVNIICFQEAWNMPFAFCTREKLPWTEFAESAEDGLTTRFCQKLAKKHNMVVVSPILERDREHGGVLWNTAVVISNSGLVMGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNPSATIGELSESLWPIEARNAAIANHCFTCALNRVGQEHFPNEFTSGDGKKAHHDLGYFYGSSYVAAPDGSRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKMTGRLEMYARELAEAVKPNYSPNIVKEDLVLAPSSG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q03248-1", "uniprot_id": "BUP1_RAT", "id": "Q03248-1", "name": "Beta-ureidopropionase", "aln": "MAGPEWQSLEQCLEKHLPPDDLSQVKRILYG-KQTRNLDLPRKALEAASERNFELKGYAFGAAKEQQRCPQIVRVGLVQNRIPLPTSAPVAEQVSALHKRIEEIAEVAAMCGVNIICFQEAWNMPFAFCTREKLPWTEFAESAEDGLTTRFCQKLAKKHNMVVISPILERDRDHGGVLWNTAVVISNSGLVMGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSVNGAEIIFNPSATIGELSESMWPIEARNAAIANHCFTCALNRVGQEHYPNEFTSGDGKKAHHDLGYFYGSSYVAAPDGSRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKMTGRLEMYARELAEAVKPNYSPNIVKEDLVLAPSSG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UBR1-1", "uniprot_id": "BUP1_HUMAN", "id": "Q9UBR1-1", "name": "Beta-ureidopropionase", "aln": "MAGAEWKSLEECLEKHLPLPDLQEVKRVLYG-KELRKLDLPREAFEAASREDFELQGYAFEAAEEQLRRPRIVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQEAWTMPFAFCTREKLPWTEFAESAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLWNTAVVISNSGAVLGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANHCFTCAINRVGTEHFPNEFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQVNDVWNFKMTGRYEMYARELAEAVKSNYSPTIVKE---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VI04-1", "uniprot_id": "Q9VI04_DROME", "id": "Q9VI04-1", "name": "Beta-ureidopropionase", "aln": "MSAFELKNLNDCLEKHLPPDELKEVKRILYGVEEDQTLELPTSAKDIAEQNGFDIKGYRFTAREEQTRKRRIVRVGAIQNSIVIPTTAPIEKQREAIWNKVKTMIKAAAEAGCNIVCTQEAWTMPFAFCTREKFPWCEFAEEAENGPTTKMLAELAKAYNMVIIHSILERDMEHGETIWNTAVVISNSGRYLGKHRKNHIPRVGDFNESTYYMEGNTGHPVFETEFGKLAVNICYGRHHPQNWMMFGLNGAEIVFNPSATIGRLSEPLWSIEARNAAIANSYFTVPINRVGTEQFPNEYTSGDGNKAHKEFGPFYGSSYVAAPDGSRTPSLSRDKDGLLVVELDLNLCRQVKDFWGFRMTQRVPLYAESFKKASEHGFKPQIIKET--------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:. * :.*::******* :* :***:*** :: :.*:** .* . *....*:::** * * :** * :**:** :** * :*:.**: :* .*: . :: : :.** .* **:* ****.**********:** ****.**:* **:: :*** ::**:: .***** :** .:*********** :** ********************* *****:*:**::*********** **:*:.:*****:******** ***.:*.********** ** .:**** *::***:*****:***:::* ***********.****.***.:*****.:*:****:*::*.* *:** * :**..: :* : .:.* *:** ", "identical_positions": 229, "similar_positions": 101, "identity": "58.12%" }, { "cls_id": "homologset.agr.HGNC:16298", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AE48-1", "uniprot_id": "MIDN_RAT", "id": "D4AE48-1", "name": "Midnolin", "aln": "-----------MEPQPGGARSCRRGAPGGACELSTT--------------------------AESAAPMSLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQPPATPGPGRAAGGGFRKYRLILFKRPWHRQGPQSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAP---------------------------------------------LQHRHVLAAAAA---------AAAAARGDSSIAT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------PVSSPCRP----VSSAARVPPVSSSPSS--------------PVSPSP---------------------------------------------------------------------------------------------------------------------------------------------------VTAGTFQSHAASTTCPEQTDCSPP------------------------------------------------------------------------------------ASS------NTTSTPGSS--PTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQG--------------------------------------------------------MPASLTQLRCHAQCS-PASPAP----------DLTPKTTSCEKLATP---SLLQGQS-----------QIRMCKPPGDRLR---------QTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGR---------------------------------------------------SDSSSSGGGGSPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TPJ7-1", "uniprot_id": "MIDN_MOUSE", "id": "Q3TPJ7-1", "name": "Midnolin", "aln": "-----------MEPQPGGARSCRRGAPGGACELNTA--------------------------TESAAPMSLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQ-------------------------------------------VSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAP---------------------------------------------LQHRHVLAAAAA---------AAAAARGDSSVAT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------PVSSPCRP----VSSAARVPPVSSSPSS--------------PVSPSP---------------------------------------------------------------------------------------------------------------------------------------------------VTAGSFRSHAASTTCPEQMDCSPP------------------------------------------------------------------------------------ASS------SSTSTPGSS--PTPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQG--------------------------------------------------------MPPSLTQLRCHAQCS-PASPAP----------DLTPKTTSCEKLAATSSTSLLQGQS-----------QIRMCKPPGDRLR---------QTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWTPSRKAGR---------------------------------------------------SDSSSSGGGGGPSEATGLGLDFEDSVWKPEVNPDIQSEFVVA------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q504T8-1", "uniprot_id": "MIDN_HUMAN", "id": "Q504T8-1", "name": "Midnolin", "aln": "-----------MEPQPGGARSCRRGAPGGACELGPA--------------------------AE-AAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQ-------------------------------------------VSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAP---------------------------------------------LQHRHVLAAAAA---------AAAAR-GDPSIAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------PVSSPCRP----VSSAARVPPVPTSPS---------------PASPSP---------------------------------------------------------------------------------------------------------------------------------------------------ITAGSFRSHAASTTCPEQMDCSPT------------------------------------------------------------------------------------ASSSASPGASTTSTPGAS--PAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQG--------------------------------------------------------MPPSLAQLRCHAQCS-PASPAP----------DLAPRTTSCEKLTAAPSASLLQGQS-----------QIRMCKPPGDRLR---------QTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGR---------------------------------------------------SDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NYU6-1", "uniprot_id": "MIDN_DANRE", "id": "Q6NYU6-1", "name": "Midnolin", "aln": "-----------MDQHP-SARSCSSRGAAPSCES-----------------------------VSGEPPMNLYIHSTTGTRFELSLPAEETVEGLKRRLSQRLKVPKERLALLHKETRLSSGKLQDLGITDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQ-------------------------------------------VSDFLSGRSPLTLALRVGDHMMFVQLQLAAQPSGG------------------------------------------PQLQHRHLISRGSSEGTTGLSHGASGSASGMARVSHN-----------------------------------------------------------------------------------------------------------------------------------------------------------------PHPHHPHQHPHHPNTTLPSNPAAFPPSPSIPSIPPMYSTSASGHCSPPPQPSQ---------------------------------------------------------------------------------------------------------------------------------------------------LPGSFLHSQQPSSACAPSPSSPSP------------------------------------------------------------------------------------AASCPEASCSAKTSGNCN--TPLRSRKPGAIIESFVNHAPGVFSGTFSGTLHPNCQDSTGRPRRDIGTILQILNDLLSATRHYQG--------------------------------------------------------MPPSLTQLRYQTQCTSPNSPAPSPPPSPPHTTGLTGLPTTVPSETQPTLHPLVQCQS-----------QIRMCKPPGDRLR---------QTENRATRCKVERLQLLMQQKRLRRKARRDSRAPYHWLPNRKAGR---------------------------------------------------SNSNSS----MSSEGS-LDLDFEDSVWKPDVKADMKSEFIMA------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8SXD4-1", "uniprot_id": "MIDN_DROME", "id": "Q8SXD4-1", "name": "Midnolin homolog", "aln": "MDKSAATNSATADGQNEAAAAAAAAATAAGCGSNNSSSTSSSNNTANSNNALQRLATTTSAVVASPMTINLNISTTTGGNFGVSVEPHISVESLKKIIAKKLKVAKDRICLLHREKELQDGTLRDHNLMDGSKIILIPNVETGLLAQR--PENTVMQALESLNDAQ-------------------------------------------VNDFLSGKTPLNLSMRLGDHMMLIQLQLSTVNPAGGGAATVAPVAGGASGSSINAAASTTSTVPVMPAGTGCSGANSTSLSSSAVLAAAAAGVGGSTGTSGSGTSSSSSSTSSSSSSSSSSSRTRSSGQRSSGRIGHGHVHSHQHPSLHAANWHGFSHGHGHGHSHGNGHGHHHHHHHHHHHHHHHHNASAVAAGSGGGMSSLRKMYGDLPSSSGASGSAPATGTGQSQSSSTLNGPDLTKLLIKGGIQNIVNSFALKDAGANARPVANGGSGSSPGKPVLEQSPIKSLSNLVSSPIKMTTIKNIPLPTTAATSSSSSCNCSSAAPSSSSSTSSGACATGGCQQDPIAAKLTSCLCTRLPTPSVAPPVATLVAPAPVARSGSTSSPSKCPESSCSGANAGFAARSTLAGTRVTFSGNSMLHKTGNNRITRTKHRHYHGQGHGHGHGNGHSSSSSSSSSSSSSHFFNHACAGNQPSVNAAAFATSSSSSSSSPSSSSSSPSKRRKLEQGMGAGAVGATAATATAAATVALPASTSATTAEPDDSLLGVSDTRTLAEASRNLTQTLRKLSKEVFTNKIDLSGAGVVSSGRSSSSGATSSGAASGEEAPRKSGSGAVIESMKNHGKGIYSGTFSGTLNPALQDRFGRPKRDISTVIHILNDLLSATPQYGRGARISFEAPTTGSVSGSGSGSGSSGSSSTTSSGSGLHHGSRSKMYSSKHHNCAKCNSRAQQQQQQSATLASGSGGSCSFRDCPSYHSSSAATKASTSSKSSSHSCCQTAEAPSSMTSQSNGCTCRYRRDDGQGEREREHTCQKCTVELANMKTRSKMDQLRLVMQQHKQKREARKLKSGPYATAASASAADSLSSIAAGGTAAVPMGAAAQYSAVSALVATPLQPAAVPVQTGKAAPANSITGNSSNANVNGNTSTAPATAATSAAAAPTAAPPSEVSPNHIVEEVDTAA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .* :. ... .* . .:.* * :*** .: ::: . :**.*:: ::::***.*:*:.***::..*..*.*:: .: ****: *:*.**:**::* **::********.::* *.*****::**.*::*:*****::****:: . *. ::: .:: .:.: . . : . * :. *.. ... . * . ** : .. : : .*::.. . ..... .:* .:.:: .. . *. .**:***: **. *::********:* ** ***:***.*:::********* :* .. * : : .: . .... . : .:: . : : * : * . *:* * : * **.*:::*:*::**:: :*:**: .** .. .*. .:*..: .* .. :. .. .::..:.:: ", "identical_positions": 129, "similar_positions": 191, "identity": "11.05%" }, { "cls_id": "homologset.agr.HGNC:16299", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZW34-1", "uniprot_id": "D3ZW34_RAT", "id": "D3ZW34-1", "name": "", "aln": "MLPGTSQVPTEASMSWVLLSVLWLIIQTQVTDTTLTAELKPQKIVHPKKLPISQRRGLENNQTESYAKEERYAPEVQYQIILNGEEIIFHLKRTKHLLGPDYTEISYSPRREEMTRRSQNVKPCYYEGHIQNAKGSLASISTCDGLRGYFTHRDQKYQIMPLQSTDEGEHAVIPHNWEEPGAVNYKHSEKQIGRKRSHLRTSRSLKSP-NEDSLQGQKYIGLFLVLDNSYYKMYKGNVTRMRSFVFEVLNLLNVIYKTIDIQVSLVGMEIWSDRDKIKVVPNLGATFTNFMRWHYSNLGQRIHNHAQLLSGAGFLHGRVGMAAANSLCTTSSVSVIEAKRKNNVALVALMSHELGHALGMQDVPYYTKCPSGSCVMNQYLSSKFPKDFSTVSRSRFQGFLSSRNTRCLLLAPDPKNIIK-PTCGNRLLDMGEGCDCGSPEECTNLCCEPLTCRLKSQPDCREEASNLVIE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0X2-1", "uniprot_id": "ADEC1_MOUSE", "id": "Q9R0X2-1", "name": "ADAM DEC1", "aln": "MLPGTSRLPTEASMSWVLLSVLWLIIQIQVIDATLTPELKPHEIVRPKKLPISQKRGLENNQTERYGKEEKYAPEVQYQIILNGEEIVFHLKRTKHLLGPDYTETSYSPRGEESTRHSQDVKPCYYEGHIQNARGSLARISTCDGLRGYFTHRDQRYQIKPLQSTDEGEHAVLPYSWKGQDTVHDKDAEKQVVRKRSHLRTSRSLKNP-NEDLLQGQKYIGLFLVLDNAYYKLYNGNVTQMRTFLFKVLNLLNMIYKTINIQVSLVGMEIWSDQDKIKVEPNLGATFTHFMRWHYSNLGKRIHNHAQLLSGASFRHGRVGMAAGNSFCTTSSVSVIEAKKKNNVALVALMSHELGHALGMKDVPYYTKCPSGSCVMNQYLSSKFPKDFSTVSRSHFQGFLSSRNARCLLLAPDPKNIIK-PTCGNQVLDVGEECDCGSPEECTNLCCEPLTCRLKSQPDC-SEASNHITE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15204-1", "uniprot_id": "ADEC1_HUMAN", "id": "O15204-1", "name": "ADAM DEC1", "aln": "MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * *::*: *:******.*****:* *. . *.**. ::** **** * ::* ::***** :.***:* ******:*******:: *::*********** **** ** * :.:::: ***:*:* * :.*:* *************:.*:*** **:**** ****:. . : ...: . . *. *:. :* *****.* :** *:.****.*:*****::** *: *:* :*:*:*.*:****:**:**::**:********* ***** *. .:** :*:*** ****::**:******* .* : ***:**.**:*:.***:*****:*******.:*******.*** ***: ************************ .*::*: :* *::.:*** ** *.**:. *.***::*::** ******:********.***:**. .** :*.* *", "identical_positions": 285, "similar_positions": 118, "identity": "60.64%" }, { "cls_id": "homologset.agr.HGNC:163", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z1P2-1", "uniprot_id": "ACTN1_RAT", "id": "Q9Z1P2-1", "name": "Alpha-actinin-1", "aln": "--MDHYDSQQ----------TNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQ----------------------GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TPR4-1", "uniprot_id": "ACTN1_MOUSE", "id": "Q7TPR4-1", "name": "Alpha-actinin-1", "aln": "--MDHYDSQQ----------TNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQ----------------------GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P12814-1", "uniprot_id": "ACTN1_HUMAN", "id": "P12814-1", "name": "Alpha-actinin-1", "aln": "--MDHYDSQQ----------TNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQ----------------------GEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T375-1", "uniprot_id": "A0AB32T375_DANRE", "id": "A0AB32T375-1", "name": "", "aln": "--MDHHHHPQHHHHHQYDGGENDYMQQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALGFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYNKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDISNSWGRLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTDGKEEMLQHKDFETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELEYYDSPSVNARCQRICDQWDSLGVLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGQNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGNDAQKRTGMMDAEDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDSVPGALDYMSFSTALYGESDL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P18091-3", "uniprot_id": "ACTN_DROME", "id": "P18091-3", "name": "Alpha-actinin, sarcomeric", "aln": "MMMENGLSMEYG---------DGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:: : :.**: *::*:*: **********:**************** *:*******:************** *.**:*****.***:******.*******:************* *********************** :********************:****:*:****.**********:**** ** **:*: **********::****:***.:*::.*.:***:*******.:****.***:. *********** ******:***:**:************:***:.* .:*:: .:*:***::* *** ****:*::*.:** ****************::*:**: ****.*:* ** .**.:***** * *****:***:**::** ** ** *** **: :*:. ..*.*:*** **************************** *:*:*. *******:****** **.***:* **:.:*::**.** *:**:**********::*: *** * *****:****** **:****** :**** *:.: .*: .**: ::: . *****:..:::. **..******:***:* :* :**:** **:**. :**::****: :*: : *.: ::*:***** :*::**::: ***:*::** ** :**::**:*::***.** :*********:* *.***:********:*******:****:******::::* *..****:**:***:.**:* * *: :* **:::****. * * *:**:***:**::*****:**: **::**.** ** **************** **.** **:.*****************:**", "identical_positions": 606, "similar_positions": 197, "identity": "63.92%" }, { "cls_id": "homologset.agr.HGNC:1630", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QZA6-1", "uniprot_id": "CD151_RAT", "id": "Q9QZA6-1", "name": "CD151 antigen", "aln": "MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQ-------QLNTELKENLKDTMIKRYHQSGHEGVTNAVDKLQQEFHCCGSNNSRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCGKREHASNIYKVEGGCITKLESFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35566-1", "uniprot_id": "CD151_MOUSE", "id": "O35566-1", "name": "CD151 antigen", "aln": "MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQ-------QLNTELKENLKDTMVKRYHQSGHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P48509-1", "uniprot_id": "CD151_HUMAN", "id": "P48509-1", "name": "CD151 antigen", "aln": "MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQ-------QLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BLG9-1", "uniprot_id": "A0A8M2BLG9_DANRE", "id": "A0A8M2BLG9-1", "name": "Tetraspanin", "aln": "MADAEEKTNSCGTVCLKYLLFVFNLLFWLAGGAVMAVGIWTLLDKSDYISLLSSNTYMVAAFILIGAGAVVVFTGILGCCATIREQRSLLIVFLILLLLIFLLEITAGVLAYVYYQECFPLCYQLNAELRADLKERMVENYQQPGQEHITRAIDNLQQDLKCCGSNSSADWRDGAWIRN-YADRRLVPDSCCKTPSVGCGVRDHPSNIYKVEGGCISKLEEFILQHLLILGSVGLGIAFVQIVGMIFTCCLYRSLKEEIY", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.: :**. :***********.:* ***** ********** ********:*.**:.:*:**: **.**:.**:******::*:*.** :::****:****** **:***.*** ***:**: :**: * :.*:*.*:* :: *:*:***:::*****.* **:*. ***. *. *:******** . ** *:*.***********:*** ** :** ::*:**:*** **:.************* * *", "identical_positions": 162, "similar_positions": 61, "identity": "62.31%" }, { "cls_id": "homologset.agr.HGNC:16305", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZXM1-1", "uniprot_id": "D3ZXM1_RAT", "id": "D3ZXM1-1", "name": "", "aln": "--------------MLLLG----ISILALAWRPASSSEPEWEVVVPIRR---------DPDINGRHYYRRGTE-------DSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQR---------------------------------LTGSSLDLRRCFYSGYVNAE--------------------PDSFAAVSLCG--GLRGAFGYQGAEYVISPLPNTSAPEAQRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTG--------------VGESHNRRRSGRAKRFVSIPR----------YVETLVVADESMVKFHGADLEH--------YLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRDT-GPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKP----ITLPEDLPGTSYSLSQQCELAFGVGSKPCPYMQY-CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVER----------------------------------------HNPNKYRVDG---SWAKWEPYGPCSRTCGGGVQLARRQ------CSNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQ--RGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSVLRYSGTGTAVESLQASRP-ILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSRPKD-PRGP-PVLRN---------SVLSLSNQVE----QPDNRPPARWVAGNWGPCSVSCGSGLQKRAVDCRD--SPGQQGISACDVDHRPVEKRACG-EPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59384-1", "uniprot_id": "ATS15_MOUSE", "id": "P59384-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 15", "aln": "--------------MLLLG----ISILALAWRPAGSSEPEWEVVVPIRR---------DPDINGRHYYRRGTE-------DSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQR---------------------------------LTGSSLDLRRCFYSGYVNAE--------------------PDSFAAVSLCG--GLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTG--------------AGESHNRRRSGRAKRFVSIPR----------YVETLVVADESMVKFHGADLEH--------YLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRDT-GPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKP----ITLPEDLPGTSYSLSQQCELAFGVGSKPCPYMQY-CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVER----------------------------------------HNPNKYRVDG---SWAKWEPYGSCSRTCGGGVQLARRQ------CSNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQ--RGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSVLRYSGTGTAVESLQASRP-ILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSTRPKD-PRGS-PVLRN---------SVLSLSNQVE----QPDNRPPARWVAGSWGPCSVSCGSGLQKRAVDCRD--SPGQQGASACDVDHRPLEKRACG-EPCPTWELGNWSPCSKSCGRGFKRRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TE58-1", "uniprot_id": "ATS15_HUMAN", "id": "Q8TE58-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 15", "aln": "--------------MLLLG----ILTLAFAGRTAGGSEPEREVVVPIRL---------DPDINGRRYYWRGPE-------DSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQG---------------------------------LTGGSSDLRRCFYSGDVNAE--------------------PDSFAAVSLCG--GLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAG--------------FGESRSRRRSGRAKRFVSIPR----------YVETLVVADESMVKFHGADLEH--------YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDS-GPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKP----ISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQY-CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVER----------------------------------------HNLNKHRVDG---SWAKWDPYGPCSRTCGGGVQLARRQ------CTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQ--RGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRP-ILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKD-PRGP-SVLHN---------SVLSLSNQVE----QPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRG--SAGQRTVPACDAAHRPVETQACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2BIA3-1", "uniprot_id": "A2BIA3_DANRE", "id": "A2BIA3-1", "name": "", "aln": "-------------MFLLLRSVLLVNVFYAQWRIVNSMQS--QLCVPIRM---------DHVKNS---LVDDED-------SILPRKAVFKISAFEQDFVLELRSDSSFIAPGFSARTDSAAHNS---------------------------------AHG--EDLSRCFYAGEVNSD--------------------PYSYAALSLCK--GLQGAFGYDGWEYFIKPASNN----TDRDNEAAHLIRRR-SNADLSGNSTSRCGVDSNATQTVAQSLAKFKHLKEQH-------------MNNVTMSFLRNRSKRFVSIPR----------YVETLVVADESMAKFHGDDLKH--------YVLTLMSVAAKLYKHPTILNSINIVVVKFMVINEEEK-GPKVSGNAAMTLRNFCTWQKKLNKNNDKHPEYWDTAILFTKQDLC----GSSTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKACEEVFGKLQDNHMMSPTLIRINRTSPWSPCSAAIITDYLDSGHGDCLLDQPEKP----LALPDVLPGASYGLERQCELAFGAGSKPCPFMQAPCQRLWCTGKTRGQLVCQTRHFPWADGTSCGDGQLCMRGTCIDK----------------------------------------QELLKTKVDG---KWGKWGPFGSCSRTCGGGVQLSKRE------CDNPVPVNGGKYCQGVRVKYRSCNLSPCP--DTGKSYREEQCEAYNGFSLNTNRLTSSVVWVPKYSGVSAKDMCKLICRANGTGYFYVLAPKVVDGTPCSPDSSSVCVQGKCIKAGCDGKLGSNKKSDKCGVCGGDNKNCKKVSGLFTKPMHGYNFVVMLPMGSSNIDIRQ--RGYKGITSDDNYLAVKNNQGKYLLNGNYVVSAMEKDILVKGSLLRYSGTVGSSETLQAVKP-LGEALIIEVLSVGQMTPPRIRYSFYLPRESKDNKAQKKEEKARAENSILREEGGVNKGGKEADILKDKIAPAYVKDIASKPGKWVAAGWDVCSVTCGNGLQRRMVQCLG--GDGGPGV-DCEPSQKPSAIQACG-DPCPMWDVGDWSPCSKTCGKGFKRRLLRCITTVGKLLPREKCVDKKKPQELDFCSLAPCK--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W1Z6-1", "uniprot_id": "Q9W1Z6_DROME", "id": "Q9W1Z6-1", "name": "", "aln": "MTVAAIGSNRHRRLALIVLTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPT-----MHIMSPKLGSGK--VTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSK---MEICRDLHCRQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHK-VPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCAR-------------YRQKVR------GLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQLRTRRKRSSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADELSSKSR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:: : . .: : :* : * : . *:: : :: . . *. : . . . : : .* . : . **:.** .::*.* * : .* * . :. :. * .:* . . : : . * : : . ** ::** :..*..: . :: ::*::: . **:**:: . **:*: :. : . : * : :. *..** **:*** .* .* ::* *:::* ** * :..:.:*** * ** . **:: * . : *.*..***:** :.* ** : . : *:***.* . .** ** : : *:* . :.:**:*: . . : *** : .:** * ** . .. . * . * .* :**.** . * *:* : : . .: * .*.:* ..*. * * . : * * . * * :: :** * . :: .: :. . .** :*. ..* : *: ... : : . .. ... .*:. : *:.*:* : .**.. .. : *.. . . : : :. :: . : . * .. : : . : .:.*:: . * : . : : .: * . : *: . :* . : .* :*. . . : : . : : .. . ::: . ::.. . . :* * * . :. * * : * * : . . .. . * * : . *: : : . .::. : ", "identical_positions": 142, "similar_positions": 282, "identity": "12.18%" }, { "cls_id": "homologset.agr.HGNC:16306", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZW03-1", "uniprot_id": "A0A8I5ZW03_RAT", "id": "A0A8I5ZW03-1", "name": "", "aln": "--------------------------------MEASADSSEASAACRFFLEGRCRFGARCRQPHPGAPAPSPEVAQP------------------------------EARSKKPALRTAADVIRRIRWDPRLDPADFSVGYTDRFLGVQEEPFCAFCWDEPLAALG-PGVLAVPQHRIRYFRFRGRLVWDRASRTDLIFGSGSVAGRGPTILDALDDRDEHWREVKAEIPDTEKTGVGFEDLDTQGAPEEGGGNPTTTGLDTGLETQEEGGAIKETRTGLDSGLETPEEGGTIKEARTELDSSLETPEVDGPTKETVLNGTTELETPDPSI-CCSGVKEISVQ---VPKATVLSQWQVQVLETSGLSADEMESVWDPGAWPDDRR------APRKPRPTHFVALMVTEPGLRAEVVKAQEHLVRIAPYCAEFLVPAQALHLTVVLLRITGPGEEAAAVRALRRAILKPGLQAPSELQFR-DLILLGHHVLCATPSP--TLASMVQTLNQRLEAEGLRVVQLP-ELQPHLTLAKVPHG-----TQVCLPKPEYILNEELGRQPLEKLWLCRMGR---AGQSYLPLAQIPLN--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BTN6-1", "uniprot_id": "LENG9_MOUSE", "id": "Q8BTN6-1", "name": "Leukocyte receptor cluster member 9", "aln": "--------------------------------MEASADSSEAPAVCRFFLEGRCRFGARCRQPHPGAPAPSPVVTQP------------------------------EAGSKKPALRTAADVIRRIRWDPRLDPADFSVGYTDRFLGVQEEPFCAFCWDEPLAALG-PGVLAVPQHRIRYFRFRGRLVWDRASRTDLIFGSGSVAGRGPTILDALDGGDEHWTEVTAEIPDTEKTGVGLEGLDTQDALAEAGGNPTGTGLDSGLETHEEGGAIKETRTGLDS--------------------SLETPEVDGPTKETGLNGTTELEMPDPSM-NFSGVKISSVE---EPRATLLPQWQAQGMETKGLSAEEMGNVWDPGVWPDDRR------APRQPRPTHFVALMVTESGLRAEVVKAQEHLVRIAPSCAEFLVPAQALHLTVVLLRLTGPGEEAAAARALRRAILKPGLQAPSQLQFR-DLVLLGHHVLCATPSP--TLTGMAQTLNQRLEAEGLRVVLLP-ELQPHLTLAKVPHG-----TQVCLPKPEYTLNQELGRQPLSKLWLCRMGR---AGHSYLPLVEISLK--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96B70-1", "uniprot_id": "LENG9_HUMAN", "id": "Q96B70-1", "name": "Leukocyte receptor cluster member 9", "aln": "MGSRPPCGATSSARRACQFPAPMAAAREPELPQEAPATEPAPPPACRFFLEGRCRFGARCRQPHPGAPAPPGREAQP------------------------------EAGAKKPPLRTAADVIQRIRWDPRLDPADFSVGYVDRFLGVREEPFSAFCWDQPLAALG-PGVLAVPQHRVRFFRFHGRLVWDRASRTDLVFGSGSAAGRGPTILDAPNTEGAHG----AEGAEWTLAGTG---QEAQAAPKRGSTRPLCTG-------HQEPG--------------------------------VEEPGELEAAQERALGTAADLGTLAPRG-RLAGVTEEALKPTAATRTTLLGGKEAQALGVPGGSAETTEAEWGPAAWPEDKRARLSVAAPCQPRPTHFVALMVTEPGLQAEVTKAQEYLVHVAPHCANFLVPSQNLHLTLALLRLAGAGEEAAAIGALRRALLAPGLNAPPRLSFR-KLVLLGPHVLCAPPSP--TLESMAQVLSQRLEAEGLSTLQSPGQLHPHLTVAKVPHG-----SQVHLPKLEFTLSQEVGCQPLQTLWLCRIGR---TGGPFQPLAEIRLE--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6J5-1", "uniprot_id": "A0ACD6B6J5_DANRE", "id": "A0ACD6B6J5-1", "name": "", "aln": "------------MEIEEETTRGNPTEESDQQIQPDEIKQETGPNICQHFLLGRCHFGDRCRLSHSVLDVPQTTNSEKDDTAVTEKQSKSRKNGKKCHTDIQHENIEKKGSKKKPRMRTADEVISRIIWDASVHPDDFIVGHLDRFLGVLERPFSDFSWDTQVCDCDFSEELALPRHRIQYFSYKGQRVWDRDSRTDRVFGS-----TGQTILPPFCGENQQQDNLTSDTGQQEESTNAADVSTDPDQSTELSEVQDDVASVITPSKNKQSQGDALNHSGNEN------------------AEEETKDHILLSRTESAPEGENTATAEDPTLNHLAGNLTVTQK---VEQAEIAEEWKDSWDGVSGSEAELASAILPQ---PQSKR-------PPPRKPTHFICFRVDSPAALQAFQRVQRKVLSTLPQSEPMWVNPATLHVTLSLLVLN-SAEEVSAAAELMRTIVRSSHKPPISVTFAPKLKHFNGTVLHVVPQPSSDVQSLNSPLQEAFKDKGWLHRHSR-CPSYHLTLAKVKREPKAEKMFEGIGTVKLAKDVNFGKLEVNKLYLCVKGQRNTESGFYQVVCAVQLPNV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . *:.** ***:** *** .*. .* :: :. *** :*** :** ** **. :.* ** **: ****** *.**. *.** :. . . **:*:**:::* ::*: **** **** :*** * *** . . : :: : : . . . .. ::: . * * :* : : :: : : . . * .*: *:.:* * :****:.: * ... . :.*. :: * . : * . **:*: ** : ..**.:* * *::: .. :.* : * .* :. ** . *.* : .: . *.: :: :* ***:*** : : . : . :.* :..*:** *: . : : : * ", "identical_positions": 111, "similar_positions": 126, "identity": "18.75%" }, { "cls_id": "homologset.agr.HGNC:16309", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z7A9-1", "uniprot_id": "D3Z7A9_MOUSE", "id": "D3Z7A9-1", "name": "", "aln": "------------------MTFVFTAVLCLGLNLGQETSMSEGNPHKPTLSVQPGLVVAKGKQVTISCEVTTGAREYRLYKEGGPHPWRTRNTPKTTNKAQFLIPSIEQRSGGIYRCYYKTPTGWSEHSDPLELAVTGLYSKPSLSTQPSNVVNSGETVTLQCVSTLGFNRFVLTKEGEQKWSLIQESEFINSTGQFQGLFTVGPVTPSQRWIFRCYGYHVNSPQVWSEPSDLLEIHVSEADQPLRPSPNISDPKTVSQPQNYTMENLIRMGASILVLVLLGVLLFEAQHSQRQTQHAAGRESSASFMVADTWE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A6Y0-1", "uniprot_id": "D4A6Y0_RAT", "id": "D4A6Y0-1", "name": "", "aln": "------------------MTFIFTAVLYLGLNLGQETSGLEGNPHKPTLSVQPGSLVARGKQVTILCEVTTGAQEYRLFKEGGPHPWRTKNTPKATNKAQFLISSIEQQHGGIYRCYYKTPSGWSEHSDPLELVVTGLYSKPSLSIQSSTVVTSGETVTLQCVSQLGFNRFVLTKEGEQKPSLIRDSEFINSTGQFQGLFPMGPVILSQRWMFRCYGYYVNSPQVWSEPSDLLEIHVSEAAQPLGLSPNISHPKTVSQHQDYTMENLIRMGVSVFILVILGILLFEAQHSQRRTQHAAGRESSTFFMVAETWG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A6NI73-1", "uniprot_id": "LIRA5_HUMAN", "id": "A6NI73-1", "name": "Leukocyte immunoglobulin-like receptor subfamily A member 5", "aln": "MAPWSHPSAQLQPVGGDAVSPALMVLLCLGLSLGPRTHVQAGNLSKATLWAEPGSVISRGNSVTIRCQGTLEAQEYRLVKEGSPEPWDTQNPLEPKNKARFSIPSMTEHHAGRYRCYYYSPAGWSEPSDPLELVVTGFYNKPTLSALPSPVVTSGENVTLQCGSRLRFDRFILTEEGDHKLSWTLDSQLTPS-GQFQALFPVGPVTPSHRWMLRCYGSRRHILQVWSEPSDLLEIPVSGAADNLSPSQNKSDSGTASHLQDYAVENLIRMGMAGLILVVLGILIFQDWHSQRSPQAAAGR-------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: : .:* ***.** .* ** *.** .:** ::::*:.*** *: * *:**** ***.*.** *:*. :..***:* *.*: :: .* ***** :*:**** ******.***:*.**:** .* **.***.***** * * *:**:**:**::* * :*:: * ****.**.:*** *:**::**** : ************ ** * : * * * *.. *.*: *:*::******* : ::**:**:*:*: **** .* **** ", "identical_positions": 149, "similar_positions": 71, "identity": "47.6%" }, { "cls_id": "homologset.agr.HGNC:1631", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q2VLH6-1", "uniprot_id": "C163A_MOUSE", "id": "Q2VLH6-1", "name": "Scavenger receptor cysteine-rich type 1 protein M130", "aln": "MGGHRMVLLGGAGSPGCKR-FVHLGFFVVAVSSLLSASAVTNAPGEMKKELRLAGGENNCSGRVELKIHDKWGTVCSNGWSMNEVSVVCQQLGCPTSIKALGWANSSAGSGYIWMDKVSCTGNESALWDCKHDGWGKHN-CTHEKDAGVTCSDGSNLEMRLVNSAGHRCLGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGPIWLDDLACNGNESALWDCKHRGWGKHNCDHAEDVGVICLEGADLSLRLVDGVSRCSGRLEVRFQGEWGTVCDDNWDLRDASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISCEGHEATLWECKHQEWGKHYCHHREDAGVTCSDGADLELRLVGGGSRCAGIVEVEIQKLTGKMCSRGWTLADADVVCRQLGCGSALQTQAKIYSKTG--ATNTWLFPGSCNGNETTFWQCKNWQWGGLSCDNFEEAKVTCSGHREPRLVGGEIPCSGRVEVKHGDVWGSVCDFDLSLEAASVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCTHSRDVSVVCSRYIDIRLAGGESSCEGRVELKTLGAWGPLCSSHWDMEDAHVLCQQLKCGVAQSIPEGAHFGKGAGQVWSHMFHCTGTEEHIGDCLMTALGAPTCSEGQVASVICSGNQSQTLLPCSSLSPVQTTSSTIPKESEVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTVCDDNWDMTDANVVCKQLDCGVAINATGSAYFGEGAGAIWLDEVICTGKESHIWQCHSHGWGRHNCRHKEDAGVICSEFMSLRLTNEAHKENCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPIPSDKTPSRPMWVDRVQCPKGVDTLWQCPSSPWKQRQASPSSQESWIICDNKIRLQEGHTDCSGRVEIWHKGSWGTVCDDSWDLNDAKVVCKQLGCGQAVKALKEAAFGPGTGPIWLNEIKCRGNESSLWDCPAKPWSHSDCGHKEDASIQC----LPKMTSESHHG--TGHPTLTALLVCGAILLVLLIVFLLWTLKRRQIQRLTVSSRGEVLIHQVQYQEMDS--KADDLDLLKSSGVIQRHTEKENDNL-----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JVY2-1", "uniprot_id": "A0A0G2JVY2_RAT", "id": "A0A0G2JVY2-1", "name": "Scavenger receptor cysteine-rich type 1 protein M130", "aln": "MGKNRMVLLGGAGSPGYKG-FVHLGFFVVAVSSLLSVSAVTQAPEGRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGWANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHN-CTHEQDAGVTCADGSNLEMRLVNSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGQIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSGRLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISCEGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKLTGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSLWQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDLSLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQLKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVICSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIWQCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQRQASPS-QESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQLGCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKC----LPRMTLESQHG--TGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIHQVQYQEMDS--KTDDLDLLKSSENSNDSYDFNADGLTSLSKYLPISGIKRGPIIHNPLRLAFKKP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q86VB7-1", "uniprot_id": "C163A_HUMAN", "id": "Q86VB7-1", "name": "Scavenger receptor cysteine-rich type 1 protein M130", "aln": "MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTR-GGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQ--ATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNS-SSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPS-EETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQRLAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL-", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. ***** .:**.. : **:*. *.::* ***.. **.: .*****..***:******:*::::*****.*****: ***:*:****** *** ****:***** ****:*** ***********:*****. ***::******:*********.. ..: * **:******:*********. *******:** ****:*****:::* *** **:*** *******:*:***:***:********.**** .************:.***************:***.** **:*.*********::********:* * ****.:**:***.::*:***:*******:*.**********:****** ******** ******:* **:*.*** * :**************:*. ::*** ******* .**.****::*:*********:**::***::***.**:******:*************.***:** *:*****.*:*********************.****.*****.*.*******.*** : **:*****.:***** :***..*::.**************.**.****:*************** * * **:**** **:* * *******:*:*** :****:. *.. ************:** .*.* *.: .* .**.::* *.** *******.**********:********:***.**::**:***:**.** ********:****:* *****: *.****:**********::**********:**********.** : *:*********:**::*.*.** **************:*.::* . **: : ***.* ****** ***********::* **** :*:** **:******* *.********* *************:**:*.*:***** *::*:*** ** *********:**:***********: *.**:*******:::* : : . :: * : :.:: *: : *.:**.:::.::: * **** ***:****** *:**:**:**:* ::*****::** : : . * ", "identical_positions": 789, "similar_positions": 227, "identity": "67.9%" }, { "cls_id": "homologset.agr.HGNC:16312", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "id": "P83555-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MLLWFLSLVCSGFFLVQRMSAHVGSHDKPFLSAWPSYVVPLGQNVTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRCF--HPQYANVLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGIIKNSVQVSAEHHESGSHVTYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKITGVYKKPSLSALMGPVLMMSGETMALSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGKFEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNCPAYTEADTKTNNYKNLHILTGLLVTMVLVVIIIFYSCYFSKQNKSQKQAAASMEQEYEVKNTINTQNFEGQERQEVTYTELEQRIFNQNLMPPISRIS-EFSADTIVYMEIMK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83556-1", "uniprot_id": "KI3L1_RAT", "id": "P83556-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MMFEFLSLLCSGFFLVQRMSAHMGSYDKPFLCASPSYIVPQGQNVTLICDSHSKPNIFKVYKEDGFPILQLHEKTFTKSLDIGPVTPEYAGTYRCF--HHQYPNEISAHSEPLKIIISGIYMKPFLIAPQTPLANSGENVTLECHSEIMFDTYILTSHRMEILKETLQHFQESHFSGSYASFTIGPMTPDHSGTYTCYGAYNHSLYEWSDSSDPVDIKITGEYKKPSLSSVMSPVLVSE-QNMTLSCISNHQFEMFHLSREGVPQGKGIPAMQSHSGKFEAKFLLSPVIQKGNYRCYGSFKNSSHVWSSPSDPLYLPAKDN---LKNLHIQIGLLVTMVLVIVVIIIIIIIIIIIIYYYYFSKK-------SSILEQESEVKATINRQDPERQEEHKVTYIEFEQRIFNKNLMPPISQSPKEFSIDTVVYTEVMI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N743-1", "uniprot_id": "KI3L3_HUMAN", "id": "Q8N743-1", "name": "Killer cell immunoglobulin-like receptor 3DL3", "aln": "MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVSEGQHVTLQCRSRLGFNEFSLSKEDGMPVPELYNRIFRNSFLMGPVTPAHAGTYRCCSSHPHSPTGWSAPSNPVVIMVTGVHRKPSLLAHPGPLVKSGETVILQCWSDVRFERFLL--HREGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCFGSVTHLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQAG-ENVTLSCSSRSLFDIYHLSREAEAGELRLTAVLRVNGTFQANFPLGPVTHGGNYRCFGSFRALPHAWSDPSDPLPVSVTGN---SRHLHVLIG-------TSVVIIPFAILLFFLLHRWCANKKN------AVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDTSV------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : .:*: * ****:: .*:*. *****.* *. :*. **:*** * *: * *.: **:* * :*:: * :* :****. :****** * : .. ** *:*: *:::*:: ** *: **..:* .* *:* *: *: ::* ** * ::.:: : * :** ..:::***** *** *:*: .: ** * .***:** :.* * *****: .*.: :.::*** * *: :*:***. . :.*: .*.*:*:* *.*: : *****:***: .*.**.***** :....* . . . ::: : :::::::: .*: : ::** : *:* :: : *: ::*** :::: :*.:. :. *: . . ** * ", "identical_positions": 141, "similar_positions": 139, "identity": "32.41%" }, { "cls_id": "homologset.agr.HGNC:16313", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P85411-1", "uniprot_id": "KTDAP_RAT", "id": "P85411-1", "name": "Keratinocyte differentiation-associated protein", "aln": "MKIPILPIVALLSLLALHAAQGAALGTP---MEDTTSSNYPSGTEGLS-EFLNFNKLQSAFKSDDFLNWHVLTDMFKKALPFINWEFFPKVKGLRSAVPDSQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3V2T4-1", "uniprot_id": "KTDAP_MOUSE", "id": "Q3V2T4-1", "name": "Keratinocyte differentiation-associated protein", "aln": "MKIPILPVVALLSLLALHAVQGAALGHPTIYPEDSSYNNYPTATEGLNNEFLNFKRLQSAFQSENFLNWHVITDMFKNAFPFINWDFFPKVKGLRSAAPDSQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P60985-1", "uniprot_id": "KTDAP_HUMAN", "id": "P60985-1", "name": "Keratinocyte differentiation-associated protein", "aln": "MKIPVLPAVVLLSLLVLHSAQGATLGGP---EEESTIENYASRPEAFNTPFLNIDKLRSAFKADEFLNWHALFESIKRKLPFLNWDAFPKLKGLRSATPDAQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****:** *.*****.**:.***:** * *::: .**.: .*.:. ***:.:*:***::::*****.: : :*. :**:**: ***:******.**:*", "identical_positions": 53, "similar_positions": 35, "identity": "51.96%" }, { "cls_id": "homologset.agr.HGNC:16315", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96L94-1", "uniprot_id": "SNX22_HUMAN", "id": "Q96L94-1", "name": "Sorting nexin-22", "aln": "MLEVHIPSVGPEAEGP---RQSPEKSHM--VFRVEVLCSGRRHTVPRRYSEFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQEVPKELLEFLRLRHF-PTDPKASNWGTLREFLP-GDSSSQQHQRPVLSFHVDPYVCNPSPESLPNVVVNGVLQGLYSF--SISPDK--AQPKAACHPAPLPPMP-----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0G2K0V0-1", "uniprot_id": "A0A0G2K0V0_RAT", "id": "A0A0G2K0V0-1", "name": "", "aln": "MLEVHIPSVGPEAEGP---RQSPEKGHM--VFQVEVLYSGRRHTVPRRYSEFHALHKRIKKRYKVPDFPSKRLPNWRTRGLEQRRQGLETYIQGVLYLNQDVPKELLEFLRLRHF-PTDSKASSWSTLGEFLP-SDTSSQLHHRPVIGFCLDPYIHTPSPAPLPEVVVDGVLQGLYGFGTSTSPAA--AQPEANCHPAPSP-MP-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F1Q9H4-1", "uniprot_id": "F1Q9H4_DANRE", "id": "F1Q9H4-1", "name": "", "aln": "MLDHQCVSPVIEVFIPSLMREVDETGKLRKLFRVEILFNGRKHFVLRRHGEFQTLHRKVKKILRVPDFPSKRNQHLRTKPLEQRRQELEDYIQVILYQNDVVPQELLDFLQVKHFHPTSKNCSSDENQSDYCREQEYRYQSFHQRVVGFSADPYQLE-SRSDLPDIVVAGVLQGFYPKDVKVSFKKSCGKPSGVTCAPALPAHPKIPIITINRSSVSSLPV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: : * *. * *: *..:: :*:**:* .**:* * **:.**::**:::** :******** : **: ****** ** *** :** *: **:***:**:::** **. :.*. . :: : * .:: *:.* *** * **::** *****:* . * .:*.. ... * * ", "identical_positions": 80, "similar_positions": 54, "identity": "36.2%" }, { "cls_id": "homologset.agr.HGNC:16318", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DCL8-1", "uniprot_id": "IPP2_MOUSE", "id": "Q9DCL8-1", "name": "Protein phosphatase inhibitor 2", "aln": "---------------------------------------------------MAASTASHRPIKGILKNKTSAASPPVVPSAEQPRPIVEEELS----------------------------------------KKSQKWDEMNILATYHPADKDYGLMKIDEPNTPYHNMIGDDEDAYSDSEGNEVMTPDILAKKLAAAEGSEPKYRTRE---QESSGEEDNDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDDEDEE------MAETADGDSMNVEESSQGSTTSDHLQHKSQSS--------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P50411-1", "uniprot_id": "IPP2_RAT", "id": "P50411-1", "name": "Protein phosphatase inhibitor 2", "aln": "---------------------------------------------------MAASTASHRPIKGILKNKTSTTSS-VVASAEQPRRTVEEELS----------------------------------------KKSQKWDEMNILATYHPADKDYGLMKIDEPDTPYHNMIGDDEDVCSDSEGNEVMTPEILAKKLAAAEGSEPKFRTRE---QESSGEEDNDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDDEDEE------MSETADADSMNIEESNQGSTAGDHLQHKSQSS--------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NXS1-1", "uniprot_id": "IPP2B_HUMAN", "id": "Q6NXS1-1", "name": "Protein phosphatase inhibitor 2 family member B", "aln": "---------------------------------------------------MAASTASHRPIKGILKNKTSTTSS-MVASAEQPRRSVDEELS----------------------------------------KKSQKWDEINILATYHPADKGYGLMKIDEPSPPYHSMMGDDEDACRDTETTEAMAPDILAKKLAAAEGLEPKYRIQE---QESSGEEDSDLSPEEREKKRQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDEE------MLETADGESMNTEESNQGSTPSDQQQNKLRSS--------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8JNP7-1", "uniprot_id": "A8JNP7_DROME", "id": "A8JNP7-1", "name": "", "aln": "MEAVVQAEADDNNASDVQRGVGGALLAVVATQWAAMATPPRARGFAATCAIIIWRTSRFQCLFGYCRRDSRLSSSNSGSSNRNNNHKIYEIINDSQPPDVTQIARMQNNPSPQLPCKGILKTSRSFDKSGASFRKSAKFDELNVMQTFHPADKDYGHMKIDEPKTPYNYTEGFD-------ENRDELDTELLVEKLRIAANTQPSTESIE---DDGSSGDDQPLSEEERQRRREFERRRKAHYREFEAVKLARKLIQEEDDDDDDEDK------GADSRPSGSSQGASSSGRFASSSTKRSSSQADSTTSPSTSAGQNMDLEPSNN------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJE7-1", "uniprot_id": "Q9VJE7_DROME", "id": "Q9VJE7-1", "name": "Protein phosphatase inhibitor 2", "aln": "--------------------------------------------------------MDGDQVKGILKSGN--------NSAQFS-------------------------------------------------LKAAKFDEVNILATFHPAGKDYGHMIIDEPKTPFVFEEDLP----------KELDTNALIEKLRHTSKSEMPAFGIEGDSEESSADEDFPESVEEKVRRMEFERRRKVHYKEFYSVPLARRLIADEFAELTSSEFNIHCEGGMESCEACSENNQLDGEASNLTQTKYSYSESQSEYRISDHSEPEPGFSPSHHCYQKLKAELFSKAEPEELASLTHLHRMPSVNDDEPSREPRVPYPSVVPTQTQNLHEHKSSLKITSEKPTPARICKSNPDNRPGTSKKETR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : . * . *: *:**:*:: *:***.*.** * ****..*: . . : .: * :** : : * ::.*. :* * **: :: :** :** **.* : ***:** .: : ..: :: . * : .. . .:. ", "identical_positions": 42, "similar_positions": 52, "identity": "10.1%" }, { "cls_id": "homologset.agr.HGNC:1632", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QX82-1", "uniprot_id": "MUC24_RAT", "id": "Q9QX82-1", "name": "Sialomucin core protein 24", "aln": "MSGASRGLFWAATCLAALCLSAAQSN-SSASPNVTDPP----TTTSKVVPTTLTTTKPPETCESFNSCVSCVNATLTNNITCVWLDCHEANKTYCSS-ELVSNCTQKTSTDSCSVIP-TTPVPT-NSTAKPTTRPSSPTPTPSVVTSAGATNTTVTPTSQPERKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSK-ERNYHTL--------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0L9-1", "uniprot_id": "MUC24_MOUSE", "id": "Q9R0L9-1", "name": "Sialomucin core protein 24", "aln": "MSGSSRRLLWAATCLAVLCVSAAQPNITTLAPNVTEVP----TTTTKVVPTTQMPTVLPETCASFNSCVSCVNATFTNNITCFWLHCQEANKTYCAN-EPLSNCSQVNRTDLCSVIPPTTPVPT-NSTAKPTTRPSSPTPTPSVVTSAGTTNTTLTPTSQPERKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSK-ERNYHTL--------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q04900-1", "uniprot_id": "MUC24_HUMAN", "id": "Q04900-1", "name": "Sialomucin core protein 24", "aln": "MSRLSRSLLWAATCLGVLCVLSADKN-TTQHPNVTTLAPISNVTSAPVTSLPLVTTPAPETCEGRNSCVSCFNVSVVN-TTCFWIECKDE--SYCSHNSTVSDCQVGNTTDFCSVST-ATPVPTANSTAKPTVQPS-PSTTSKTVTTSGTTNNTVTPTSQPVRKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSK-ERNYHTL--------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PHX2-1", "uniprot_id": "M9PHX2_DROME", "id": "M9PHX2-1", "name": "", "aln": "-MNRQAKFLILCLFVGLFSANLCEEVTTPAPADTTTQE----SKNTTTPPDTTTTVTPPSTSTTSTTTEKTTTTPPIT-----------------TSTEKTTTSTTPASTTSSTTPASTTSSTTPATTTTTPGTTSTTTPSPNSTTTTPPPHTSTTPAPKPVPCGHFDGSSFIGGIVLTLGLLAIGLVAYKFYKARNERNYHTLXAATAFTSAFNAAAGAAAASSSAASTDAERVRFVQPSIPLRSPPTQPPPPPPTHMGGSGGGAAAAPQNCSPSARDRLLHT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: . :. :. .: :. .:.* ..: . . . .. *.*. .: . ... . : . : . * .:. . :*. .* :*:... .* .:.:.. .*:: ..:.: **:.:* . **.:********.**: *: :. *** *:: ******* ", "identical_positions": 36, "similar_positions": 76, "identity": "12.68%" }, { "cls_id": "homologset.agr.HGNC:16324", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A8JNP7-1", "uniprot_id": "A8JNP7_DROME", "id": "A8JNP7-1", "name": "", "aln": "MEAVVQAEADDNNASDVQRGVGGALLAVVATQWAAMATPPRARGFAATCAIIIWRTSRFQCLFGYCRRDSRLSSSNSGSSNRNNNHKIYEIINDSQPPDVTQIARMQNNPSPQLPCKGILKTSRSFDKSGASFRKSAKFDELNVMQTFHPADKDYGHMKIDEPKTPYNYTEGFDENRDELDTELLVEKLRIAANTQPSTESIEDDGSSGDDQPLSEEERQRRREFERRRKAHYREFEAVKLARKLIQEEDDDDDDEDKGADSRPSGSSQGASSSGRFASSSTKRSSSQADSTTSPSTSAGQNMDLEPSNN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJE7-1", "uniprot_id": "Q9VJE7_DROME", "id": "Q9VJE7-1", "name": "Protein phosphatase inhibitor 2", "aln": "-------MDGDQVKGILKSGNNSAQFSLKAAKFDEVNILATFHPAGKDYGHMIIDEPKTPFVFEEDLPKELDTNALIEKLRHTSKSEMPAFGIEGDSEESSADEDFPESVEEKVRRMEFERRRKVHYKEFYSVPLARRLIADEFAELTSSEFNIHCEGGMES-------CEACSEN-NQLDGEASNLTQTKYSYSESQSEYRISDHSEPEPGFSPSHHCYQKLKAELFSKAEPEELASLTHLHRMPSVNDDEPSREPR--VPYPSVVPTQTQNLHEHKSSLKITSEKPTPARICKSNPDNRPGTSKKETR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "O14990-1", "uniprot_id": "IPP2C_HUMAN", "id": "O14990-1", "name": "Protein phosphatase inhibitor 2 family member C", "aln": "------------------------------------------------------------------MSASTSSHRPIKGILKNKSSSGSSVATSGQQSG-GTIQDVKRKKSQKWDESSILAAHRATYR------------DYDLMKANEPGTSYMSVQDNGE---------DSVRDVEGEDSVRGVEGKEATDASDHSCEVDEQESSEAYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWKELQSEDNENE----------ETPQGTNEEKTAAEESEEAPLTGGLQTQSCDP----------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : :... . . ..: . .. . : : : : :. : . . . .: : * :: . * .: *. .. :: : * : . .* :. ::: : :. . * . ... . :: .. . .. ", "identical_positions": 6, "similar_positions": 63, "identity": "1.94%" }, { "cls_id": "homologset.agr.HGNC:1633", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P25918-1", "uniprot_id": "CD19_MOUSE", "id": "P25918-1", "name": "B-lymphocyte antigen CD19", "aln": "-----------------------------------------------MPSPLPVS----FLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSPVSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPPFKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSG----SQLYVWAKDHPKVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRRPNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHETG-----LEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSNAESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHSIQ--SGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LNH2-1", "uniprot_id": "F1LNH2_RAT", "id": "F1LNH2-1", "name": "", "aln": "MWGLPQPSQTPMVHCPLGSCLPQHPLRSRAEAGCPREPGYHAISSPCLPPPLPYLSRRQAPEFLTGGGRRGWGSPFPLPTEGDNVVLSCLRDSSPVSSEKLAWYRGNQSTPFLELSLRSPDLGLHIGPLGILLVIVNVSDHRGGFYLCQKRPSFKDTWQPAWTVNVEDSGELFRWNASDLGDLDCDLGNRSSGSHRSTSG----SQLYVWATDHPEVWKTKPVCAPREISLNQSLINQDLTVAPGSTLWLSCGVPPVPVTKGSISWTHVHPKTLNVSLLSLSLGGEHPVREMWVWGSLLLLPQAKASDEGTYYCLQGGLTIKMHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSMAAFLYFRRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAASLGSGPVSYGNPRIEVQDAGAQRHETG-----LEEEGEAYEEPDSEEGSEFYENDSNLEQDQLSQDGSGYENPEDDPVGPEEEDSFSNAESYENADEELAQPVGRTMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLQSIR--SGPSHEEDADSYENMDKSDDPEPAWAGEGHMGTWGAT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P15391-1", "uniprot_id": "CD19_HUMAN", "id": "P15391-1", "name": "B-lymphocyte antigen CD19", "aln": "-----------------------------------------------MPPPRLLF----FLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLS-QDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGP-KSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*.* *** * . . **.*.** ** .:* .:::*:* * . .***:** *.**:*: .*.* *.*.***:: ******* *. :. ***.******.***:****.**: .*.*.* **** . *.** .:*****.*:*::* :* * * ****** ****:************** .*::*.:*******: *****.* .::*.*:*** : ****:*.* * *.*** :*.**:. *::: **..:* ******** *..***.*:***: *:..:*: :**::***********:*********.*.*.************.*** .:******.**. . ***** :** ** .: *****.********.********** ***:************:*:***:************ ****:***.* *****************:********************:**: .**.************:.*. :*** * *:****.: ", "identical_positions": 341, "similar_positions": 118, "identity": "55.99%" }, { "cls_id": "homologset.agr.HGNC:16341", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AC58HX46-1", "uniprot_id": "A0AC58HX46_DANRE", "id": "A0AC58HX46-1", "name": "Type II GnRH receptor", "aln": "MALNHLSLLHRMSGNVSLSLISLLENSSLASSSSPQSPQWETPTFTTAARYRVVATLVLFVFAAVSNLSVLISVTRGRGRHLASHLRPLIASLASADLVMTFVVMPLDAIWNITVQWYAGDAMCKLLCFLKLFAMHSAAFILVVVSLDRHHAILHPLEALDAGRRNRRMLLAAWILSVLLASPQLFIFRAIKAEG-VDFVQCATHGSFQHRWQETAYNMFHFVTLYVFPLLVMSFCYTRILVEINRQMPR----GKGGEPCLRRSGADMIPKARMKTLKMTIIIVASFVVCWTPYYLLGIWYWFQPRMLQVTPEYVHHALFVFGNLNTCCDPVIYGFFTPSFR-ADITSCFSRRNQ------------------------NCSPKSLDRLSARRGGASGEAESDLGSGDQPSGQTA-------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q96P88-1", "uniprot_id": "GNRR2_HUMAN", "id": "Q96P88-1", "name": "Putative gonadotropin-releasing hormone II receptor", "aln": "-------------------------------------------------------------------------MSAGNG-------------------------TPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSG---VRKLLGAAWGLSFLLAFPQLFLFHTVHCAGPVPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRS-FDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKE------------------------GSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI-----------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7KTL9-1", "uniprot_id": "Q7KTL9_DROME", "id": "Q7KTL9-1", "name": "", "aln": "-----------MAKVAEENDHRDLSNWSNVNDTNGTIHLTKDMVFNDGHRLSITVYSILFVISTIGNSTVLYLLTKRRLRG-PLRIDIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAILKPLKRSYN--RGRIMLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAIYLEIYRKSQR--VLKDVIAERFRRSNDDVLSRAKKRTLKMTITIVIVFIICWTPYYTISMWYWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLYNIRGRMNNNNPSVNNRHTSLSNRLDSSNQLMQKQLTNNSLLNGRGQVMAAAVSATTKLANVVSLKGTANGNGSAAAAGTVPITPPLTVTIAPLATDDEANDDSCLSAVTIRCQDQSPIRQKCGDSIELTSVVK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: . * : * **** : * *: : *::::. : :::: * :.*** *:*:** * :* .** *.: : ** *:*: . . . : **. .**: ::*. *: : :: :** : ** * :.: * * : ** * .:.: ::*:::: *: *::****** :.:***:. : : **::. *: :*::** :. * . ... : . . : * : .. *: . ", "identical_positions": 63, "similar_positions": 90, "identity": "13.38%" }, { "cls_id": "homologset.agr.HGNC:16343", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "id": "P83555-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MLLWFLSLVCSGFFLVQRMSAHVGSHDKPFLSAWPSYVVPLGQNVTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRC--FHPQYANVLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGIIKNSVQVSAEHHESGSHVTYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKITGVYKKPSLSALMGPVLMMSGETMALSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGKFEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNCPAYTEADTKTNNYKNLHILTGLLVTMVLVVIIIFYSCYFSKQNKSQKQAAASMEQEYEVKNTINTQNFEGQERQEVTYTELEQRIFNQNLMPPISRIS-EFSADTIVYMEIMK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83556-1", "uniprot_id": "KI3L1_RAT", "id": "P83556-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MMFEFLSLLCSGFFLVQRMSAHMGSYDKPFLCASPSYIVPQGQNVTLICDSHSKPNIFKVYKEDGFPILQLHEKTFTKSLDIGPVTPEYAGTYRC--FHHQYPNEISAHSEPLKIIISGIYMKPFLIAPQTPLANSGENVTLECHSEIMFDTYILTSHRMEILKETLQHFQESHFSGSYASFTIGPMTPDHSGTYTCYGAYNHSLYEWSDSSDPVDIKITGEYKKPSLSSVMSPVLVSE-QNMTLSCISNHQFEMFHLSREGVPQGKGIPAMQSHSGKFEAKFLLSPVIQKGNYRCYGSFKNSSHVWSSPSDPLYLPAKDN---LKNLHIQIGLLVTMVLVIVVIIIIIIIIIIIIYYYYFSKK-------SSILEQESEVKATINRQDPERQEEHKVTYIEFEQRIFNKNLMPPISQSPKEFSIDTVVYTEVMI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A0G2JN01-1", "uniprot_id": "A0A0G2JN01_HUMAN", "id": "A0A0G2JN01-1", "name": "", "aln": "MSLMVVSMACVGFFLLQGAWPHEGGQDKPFLSAWPSPVVSEGEHVALQCRSRLGFNEFSLSKEDGMPVPELYNRVFRNTVFIGPVTPAHAGTYRCRGSHPHFLTGWSAPSNPLVIMVTGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLL--HREGKFNDTLRLTGELHDGVSKANFSIGRMTQDLAGTYRCYGSVPHSPYQLSAPSDPLDIVITGLCGKPSLSAQPRPMVKAG-ESVTLSCSSRSSYDIYHLSRDGEAHELRFPAVPKVNGTFQANFPLGPATHGGTYRCFGSFRDSPYEWSDLSDPLLVSVTDS----------------------------------------------------MKEKGKDVIL----------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : .:*: * ****:* .* *. *****.* ** :*. *::*:* * *: * *.: **:* * :*:: .* :: :****. :****** * :: . ** *:** *:::*:: ** *: **..: .* *:* *: **: ::* ** :::::: * * . * ..::** ** * *** ***: : *: * .***:** *** *****: *:: :.::*** * .:: :*:**:* .: :**: . .*.*:*:* *.* : *.***:***:::.: **. **** :..... *: :* ", "identical_positions": 125, "similar_positions": 101, "identity": "28.74%" }, { "cls_id": "homologset.agr.HGNC:16344", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "id": "P83555-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MLLWFLSLVCSGFFLVQRMSAHVGSHDKPFLSAWPSYVVPLGQNVTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRCFHPQYANVLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGIIKNSVQVSAEHHESGSHVTYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKITGVYKKPSLSALMGPVLMMSGETMALSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGKFEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNC----PAYTEADTKTNNYKNLHILTGLLVTMVLVVIIIFYSCY--FSKQNKSQKQAAASMEQEYEVKNTINTQNFEGQERQEVTYTELEQRIFNQNLMPPISRIS-EFSADTIVYMEIMK-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83556-1", "uniprot_id": "KI3L1_RAT", "id": "P83556-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MMFEFLSLLCSGFFLVQRMSAHMGSYDKPFLCASPSYIVPQGQNVTLICDSHSKPNIFKVYKEDGFPILQLHEKTFTKSLDIGPVTPEYAGTYRCFHHQYPNEISAHSEPLKIIISGIYMKPFLIAPQTPLANSGENVTLECHSEIMFDTYILTSHRMEILKETLQHFQESHFSGSYASFTIGPMTPDHSGTYTCYGAYNHSLYEWSDSSDPVDIKITGEYKKPSLSSVMSPVLVSE-QNMTLSCISNHQFEMFHLSREGVPQGKGIPAMQSHSGKFEAKFLLSPVIQKGNYRCYGSFKNSSHVWSSPSDPLYLPAKDN-------LKNLHIQIGLLVTMVLVIVVIIIIIIIIIIIIYYYY--FSKK-------SSILEQESEVKATINRQDPERQEEHKVTYIEFEQRIFNKNLMPPISQSPKEFSIDTVVYTEVMI-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A0G2JNF4-1", "uniprot_id": "A0A0G2JNF4_HUMAN", "id": "A0A0G2JNF4-1", "name": "", "aln": "MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPG---------------------------------------------------------------------------------------------PLVKSEETVILQCWSDVRFQHFLL--HREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAG-ESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVIILFILLLFFLLHRWCSNKKN-----AAVMDQEPAGNRTANSEDSDEQDPQEVTYVQLDHCVFTQRKITRPSQRPKTPPTDTRVYTELPNAESRSKVVSCP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : .:*::* ****:* .* * : ** * * *. **..: .* *:* *: *: ::* ** :*:::: * * . * ..::**** * *** ***: .: *: * .***:** *** *:*****: .*.:: :.::*** * .:: :*:**** .: : :.* . .*.*:*.* *.* : *.***:***:::.: **..**** :....* .: : . : :: : :::.:::::: : *:: :: ::** : * * :: : *: ::*** :::: :*.:. :. *: . . ** ** *: ", "identical_positions": 103, "similar_positions": 121, "identity": "22.89%" }, { "cls_id": "homologset.agr.HGNC:16345", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "id": "P83555-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MLLWFLSLVCSGFFLVQRMSAHVGSHDKPFLSAWPSYVVPLGQNVTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRC--FHPQYANVLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGIIKNSVQVSAEHHESGSHVTYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKITGVYKKPSLSALMGPVLMMSGETMALSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGKFEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNCPAYTEADTKTNNYKNLHILTGLLVTMVLVVIIIFYSCYFSKQNKSQKQAAASMEQEYEVKNTINTQNFEGQERQEVTYTELEQRIFNQNLMPPISRIS-EFSADTIVYMEIMK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83556-1", "uniprot_id": "KI3L1_RAT", "id": "P83556-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MMFEFLSLLCSGFFLVQRMSAHMGSYDKPFLCASPSYIVPQGQNVTLICDSHSKPNIFKVYKEDGFPILQLHEKTFTKSLDIGPVTPEYAGTYRC--FHHQYPNEISAHSEPLKIIISGIYMKPFLIAPQTPLANSGENVTLECHSEIMFDTYILTSHRMEILKETLQHFQESHFSGSYASFTIGPMTPDHSGTYTCYGAYNHSLYEWSDSSDPVDIKITGEYKKPSLSSVMSPVLVSE-QNMTLSCISNHQFEMFHLSREGVPQGKGIPAMQSHSGKFEAKFLLSPVIQKGNYRCYGSFKNSSHVWSSPSDPLYLPAKDN---LKNLHIQIGLLVTMVLVIVVIIIIIIIIIIIIYYYYFSKK-------SSILEQESEVKATINRQDPERQEEHKVTYIEFEQRIFNKNLMPPISQSPKEFSIDTVVYTEVMI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N109-1", "uniprot_id": "KI2LA_HUMAN", "id": "Q8N109-1", "name": "Killer cell immunoglobulin-like receptor 2DL5A", "aln": "MSLMVISMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLS--REGRAHEPRLPAVPSVNGTFQADFPLGPAT--HGGTYTCFGSLHDSPYEWSDPSDPLLVSVTGNSS-SSSSSPTEP-----------------------SSKTGIRR-----HLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMDQEPAGDRTVNREDS----DDQDPQEVTYAQLDHCVFTQTKITS---------------------PSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRGSSRETTALSQNRVASSHVPAAGI--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : .:*: * ****:* :* *. ***:*.* ** :** * :*** * *: .**.:***:* * :*::. * ** :****. :****** * : . ** *:** *:::*:: ** * * . :* ****.* *. ** * * * ::. . . :.:** * *****:*: *****.***: :.:** . .* *: * *: *: : :: *. * :*: :: : * .. :*:: : ..*:. : :.. : . : : : .: : .. *: : : : . . : ..: :. . . : ..: . : : ", "identical_positions": 101, "similar_positions": 109, "identity": "23.22%" }, { "cls_id": "homologset.agr.HGNC:16346", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "id": "P83555-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MLLWFLSLVCSGFFLVQRMSAHVGSHDKPFLSAWPSYVVPLGQNVTLTCDSHRGSNIFKLYKEEGSPNHQLHETTFQKSQVFGPVTTEHAGTYRC--FHPQYANVLSAHSEPLKIIISGIYMKPFLLILQSPLVDTGGNVTLECHSENMFDTYILISHRMGIIKNSVQVSAEHHESGSHVTYSIGPMTPDLVGTYTCYGANSYYPYEWSDSSDPIDIKITGVYKKPSLSALMGPVLMMSGETMALSCISDHQFDTFHMSREGVPRGQGMPAVQSHSGKFEAKFLLSPMIQKGNYRCYGSFRNASHVWSSPSDPLYLPAKGNCPAYTEADTKTNNYKNLHILTGLLVTMVLVVIIIFYSCYFSKQNKSQKQAAASMEQEYEVKNTINTQNFEGQERQEVTYTELEQRIFNQNLMPPISRIS-EFSADTIVYMEIMK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83556-1", "uniprot_id": "KI3L1_RAT", "id": "P83556-1", "name": "Killer cell immunoglobulin-like receptor 3DL1", "aln": "MMFEFLSLLCSGFFLVQRMSAHMGSYDKPFLCASPSYIVPQGQNVTLICDSHSKPNIFKVYKEDGFPILQLHEKTFTKSLDIGPVTPEYAGTYRC--FHHQYPNEISAHSEPLKIIISGIYMKPFLIAPQTPLANSGENVTLECHSEIMFDTYILTSHRMEILKETLQHFQESHFSGSYASFTIGPMTPDHSGTYTCYGAYNHSLYEWSDSSDPVDIKITGEYKKPSLSSVMSPVLVSE-QNMTLSCISNHQFEMFHLSREGVPQGKGIPAMQSHSGKFEAKFLLSPVIQKGNYRCYGSFKNSSHVWSSPSDPLYLPAKDN---LKNLHIQIGLLVTMVLVIVVIIIIIIIIIIIIYYYYFSKK-------SSILEQESEVKATINRQDPERQEEHKVTYIEFEQRIFNKNLMPPISQSPKEFSIDTVVYTEVMI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NHK3-1", "uniprot_id": "KI2LB_HUMAN", "id": "Q8NHK3-1", "name": "Killer cell immunoglobulin-like receptor 2DL5B", "aln": "MSLMVVSMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLS--REGRAHEPRLPAVPSVDGTFQADFPLGPAT--HGGTYTCFSSLHDSPYEWSDPSDPLLVSVTGNSS-SSSSSPTEP-----------------------SSKTGIRR-----HLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMDQEPAGDRTVNREDS----DDQDPQEVTYAQLDHCVFTQTKITS---------------------PSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRGSSRETTALSQNRVASSHVPAAGI--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : .:*: * ****:* :* *. ***:*.* ** :** * :*** * *: .**.:***:* * :*::. * ** :****. :****** * : . ** *:** *:::*:: ** * * . :* ****.* *. ** * * * ::. . . :.:** * *****:.: *****.***: :.:** . .* *: * *: *: : :: *. * :*: :: : * .. :*:: : ..*:. : :.. : . : : : .: : .. *: : : : . . : ..: :. . . : ..: . : : ", "identical_positions": 100, "similar_positions": 110, "identity": "22.99%" }, { "cls_id": "homologset.agr.HGNC:16347", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5CD99-1", "uniprot_id": "Q5CD99_RAT", "id": "Q5CD99-1", "name": "Polypeptide N-acetylgalactosaminyltransferase", "aln": "--------------MASLRRVKVLLVLNLIAVAGFVIFLAKCRPIAVRSGDAFHEIRPRAEV-ANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPSEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYS-KELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYP-GLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQR---YENSAHGYSWELWCMYISPP-------KDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTK-RNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERKALRKSLKCKNFQWYLDHVYPEMRRYNNTIAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVE-NRGLAGIDLILRS--CTGQRWTIKNPIK-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TT15-1", "uniprot_id": "GLT17_MOUSE", "id": "Q7TT15-1", "name": "Polypeptide N-acetylgalactosaminyltransferase 17", "aln": "--------------MASLRRVKVLLVLNLIAVAGFVIFLAKCRPIAVRSGDAFHEIRPRAEV-ANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPSEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYS-KELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYP-GLVKVVRNQKREGLIRARIEGWKAATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQR---YENSAHGYSWELWCMYISPP-------KDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTK-RNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERKALRKSLKCKNFQWYLDHVYPEMRRYNNTIAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVE-NRGLAGIDLILRS--CTGQRWAIKNPIK-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6IS24-1", "uniprot_id": "GLT17_HUMAN", "id": "Q6IS24-1", "name": "Polypeptide N-acetylgalactosaminyltransferase 17", "aln": "--------------MASLRRVKVLLVLNLIAVAGFVLFLAKCRPIAVRSGDAFHEIRPRAEV-ANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYS-KDLPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKVPLEEYVHKRYP-GLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQR---YENSAHGYSWELWCMYISPP-------KDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTK-RNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVE-NRGLAGIDLILRS--CTGQRWTIKNSIK-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7EZL6-1", "uniprot_id": "E7EZL6_DANRE", "id": "E7EZL6-1", "name": "Polypeptide N-acetylgalactosaminyltransferase", "aln": "MMRFTGFRTPKSFMAFVMRRWKILLVLNVFTVAGFITFWGKCNVRTTKGVGQQMAVDSRGQTNLNGSVQETSITHDVLLKRLGSLEDVVYRQLNGLSKSLGLIEGFGGRGRGGIPATLTPAEEKEAKFLREKYGYNAFLSDKISLDRSLPDYRPSKCKKAFFP-RDLPQISIIFIFVNEALSVILRSVHSAVNHTPAHLLKEIILVDDNSDDVQLKGPLEEYVNKRYP-GLIKIVRNQKREGLIRARIEGWKVATGEVTGFFDAHVEFTPAWAEPVLSRIKENHKRIILPSIDNIKDETFELER---YENSGHGYNWELWCMYISPP-------KQWWDEGDTSAPIRTPAMIGCSFVVNREYFGDLGLLDAGMDVYGGENIELGIRVWLCGGSMEVLPCSRVAHIARTKKPYHSNIAFHTR-RNALRVAEVWMDQYKSNVYLAWNLPMKNHGIDYGDVSERLALRKRLQCKSFDWYLDNIYPEMRRYNNTVFYGEIRNTNVTHLCVDQGIKENHTATLHPCHGWGPQLGRYTKEGYLFLGPLGSTG--EDTRCVVDDKISSYPQLLNCEKVSSVRQKTWHFAQNESIISRATGRCLEVVPANVYFGYALILRS--CTGQKWNIKNLMKQDQGQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6WV20-1", "uniprot_id": "GALT1_DROME", "id": "Q6WV20-1", "name": "Polypeptide N-acetylgalactosaminyltransferase 1", "aln": "-------------MLPRFRSFYGKLIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSENEIARP------ATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNR--PDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNELS----CATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHIIHSNTGMCLDHQGLKSLDDAQVAPCDPHSESQRWTIEH--------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* *:: ::.. *: : . : . : . . . . .: : : * . :. .*.* : * *. *:.. *: : ::... :* . * **:::: :**: *:* . * : : .** *:::**.**. **:**:***::. : *********.**: :* *: **..* * * :.::* ::* ******: * : ***:* *:*** * . .*.**:*.**:*.:. :::* ** *. : *: . . . *:.*: :*. * : . * :*:* * *.::*.:* ::* * ** :****:*:.:::* ***::*.:*****.** * :**: *: *: *:* ****:* . .:: * : * ***:.* *** *:**.*:***.::*** .: : : ..:*:*: :*... : * * : .: . * . . *:.. * ::: :.. : :: *: ** **: . . : . . .*:* *:: ", "identical_positions": 160, "similar_positions": 186, "identity": "25.24%" }, { "cls_id": "homologset.agr.HGNC:16348", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C0D4-1", "uniprot_id": "RHG12_MOUSE", "id": "Q8C0D4-1", "name": "Rho GTPase-activating protein 12", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERSG----KITAGQAYIEVEYDYEYDAKDRKIVIRQGERYLLVKKTNDDWWQVRPDENS----------KAFYVPAQYVK----EVTRKALMPPVKQATGLPNNSMKTIQSMHLQRSTENVNKMP--ELSSFGKPSSSVQGTGLIR---------------------DAN---QNFGSNYNSGQ-TLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLD--------IEKTSFSQEQSCDSAGEGSERIQQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAI-----------------QVNGEWETHKDSSGRCYYYNRTTQERTWK------------------------------PPRWARDVS-----------------------------TSR-DFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERG---------------------------------------------------------------HTLYTSDYTK----EKWLKHVDD-----------------------QGRQYYYSADGSRSEWELPKYNASSQ-------------------QQREIIKSRSL------------------------------------------------------------------------------------DRRLQEPIVLTK-WRHSTIVLDSNDK----------------DSPTTTKLCLPENESP--PTS--SKHQDPG-----QEKYGLLNVTK--------ITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSS-------TSW------------------------------------------------------FGSNQ-SKPEFTVDLKGAVIEMASKDKSSKK-----------------------------------------------NVFELKTRQGTELLIQSDNDAVIN-----------DWFKVLSSTINNQVAEADEAAEEETPDSP---------GVEKHDKEKDQKELKKLRS-----------------------------MKG-SSMDSSEQKKTKKNLKKFLTRRPTLQAVREK-----------------------------------------------------------------GYIK--------DQVFGSNLANLCQRENGTVPKFVKLCIEHVEEH--GLDVDGIYRVSGNLAVIQKLRFAVNHDEKLD-------LNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ----------------------EPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZDI5-1", "uniprot_id": "D3ZDI5_RAT", "id": "D3ZDI5-1", "name": "Rho GTPase-activating protein 12", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERSG----KIASGQVYIEVEYDYEYEAKDRKIVIRQGERYLLVKKTNDDWWQVRLDENS----------KAFYVPAQYVK----EVTRKALMPPVKQTTGLPNNSMKTTQSMHLQRSTENVNKMP--ELSSFGKPSSSVQGTGLIR---------------------DAN---QNFGSNYNSGQ-TLNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLD--------IEKTSFSQEQSCDSAGEGSERTHQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAI-----------------QVNGEWETHKDSSGRCYYYNRTTQERTWK------------------------------PPRWARDVS-----------------------------TSR-DFQSPGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSEELDERG---------------------------------------------------------------HTLYTSDYTK----EKWLKHVDD-----------------------QGRQYYYSADGSRSEWELPKYNASSQ-------------------QQREIIKSRSL------------------------------------------------------------------------------------DRRLQEPIVLTK-WRHSTIVLDSNDK----------------DSPTSTKLCLPENESP--PTS--TKHQDPG-----QEKYGLLNVTK--------ITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSS-------TSW------------------------------------------------------FGSNQ-SKPEFTVDLKGAAIEMASKDKSSKK-----------------------------------------------NVFELKTRQGTELLIQSDNDAVIN-----------DWFKVLSSTINNQVAEADEAAEEEAPDSP---------GVEKQDKEKDQKELKKLRS-----------------------------MKG-SSMDSSEQKKTKKNLKKFLTRRPTLQAVREK-----------------------------------------------------------------GYIK--------DQVFGSNLANLCQRENGTVPKFVKLCIEHVEEH--GLDVDGIYRVSGNLAVIQKLRFAVNHDEKLD-------LNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ----------------------EPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVELILLELSTVFGR-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IWW6-1", "uniprot_id": "RHG12_HUMAN", "id": "Q8IWW6-1", "name": "Rho GTPase-activating protein 12", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKMADRSG----KIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENS----------KAFYVPAQYVK----EVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLP--ELSSFGKPSSSVQGTGLIR---------------------DAN---QNFGPSYNQGQ-TVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHFPGPEFLD--------VEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAI-----------------QINGEWETHKDSSGRCYYYNRGTQERTWK------------------------------PPRWTRDAS-----------------------------ISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERG---------------------------------------------------------------HTLYTSDYTN----EKWLKHVDD-----------------------QGRQYYYSADGSRSEWELPKYNASSQ-------------------QQREIIKSRSL------------------------------------------------------------------------------------DRRLQEPIVLTK-WRHSTIVLDTNDK----------------ESPTASKPCFPENESS--PSS--PKHQDTASSPKDQEKYGLLNVTK--------IAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSS-------TSW------------------------------------------------------FGSNQ-SKPEFTVDLKGATIEMASKDKSSKK-----------------------------------------------NVFELKTRQGTELLIQSDNDTVIN-----------DWFKVLSSTINNQAVETDEGIEEEIPDSP---------GIEKHDKEKEQKDPKKLRS-----------------------------FKV-SSIDSSEQKKTKKNLKKFLTRRPTLQAVREK-----------------------------------------------------------------GYIK--------DQVFGSNLANLCQRENGTVPKFVKLCIEHVEEH--GLDIDGIYRVSGNLAVIQKLRFAVNHDEKLD-------LNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ----------------------EPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GV37-1", "uniprot_id": "A0AC58GV37_DANRE", "id": "A0AC58GV37-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSERDGRCDLSIAPGQVYIEVEYDYEYKAKDKLISIRQGECYMLVRKTNEDWWQVRREEGT----------KAFYVPAQYVR----EVRR-ALMPPPKPRAKPPN----VLEITHCRSSNENLNQRAPTEKSTFGRPPPSTTPSPLPG---------------------QQTPPLLLRDSNHNPGMKSVVAELTLLNNNNHHNFHHANPTLP-QGRAESPPRDQGCQGKL--------TGGLSVDTDGSVS-PGDGVEKMRNDSESGDELSSSSTEHIQSVSLSGQGRPESPVYTNLQELKICQSSVPPVPSTSPL-----------------HVLGDWETHKDTSGRNFYFNRTTQERTWK------------------------------PPR-SRDNG-----------------------------VSRGDTSNTGDMEPLSSEENCPSTHSSQSDSQYGSPPRGWSEELDEHG---------------------------------------------------------------HTLYVSEYTN----EKWIKHVDE-----------------------QGRPYYYSADGSRSEWELPKYNLSPP-------------------ISGEAPKSHSL------------------------------------------------------------------------------------ERKQQEPIVLTK-WRHSTYVLDISDKTTWFYLFA-------NKKLPFKNRWFSVNHPP--RGFGLPVYREPS------EKCGVLNVTK--------ITEHGKKVRKNWASTWTVLQGSSLLFAKGQGSG-------TSWSYCHNGSFPELLLSLLSNWKRS-------------IKPRPAVSYTHCRRARASSFGGNQ-SKPEFTVDLRGGSVEWASKEKSSKK-----------------------------------------------HVIELKTRVGTELLIQSEIDSVIN-----------DWFRALSETINTHAWESDEAIEEDMPESP---------GSEKHDKEKDPRDSKKNRV-----------------------------VKN-SSMESSEQKKTRVKLKKFLTRRPTLQAVRDK-----------------------------------------------------------------GYIK--------DQVFGCSLTALCQREGTSVPNFVKMCIEHVENT--GLNVDGLYRVSGNLAVIQKLRFAVNHDEKVN-------LDDSKWEDIHVTTGALKMLFRELPEPLFTYASFNDFVEAIKNS---------------------DYKQRVQSIKDLIKQLPKPNQETMKVLFKHLKRVIDHGEVNRMTTQSVAIVFGPTLLRPEIETGNMAVHMVYQNQIVELILLEYENIFGR-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9QA49-1", "uniprot_id": "A0A8M9QA49_DANRE", "id": "A0A8M9QA49-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADR------SIAPGQTYIEVEYDYDYKSKDRLITIKHGESYLLVKKTNDDWWQVRKDDAS----------KPFYVPAQYVR----EVRR-ALMPPPKPLNIAGRGGPAPNRPSALEIQRPNDNKKS---------PCPSPSSTALLP---------------------PRD----DRGSPVSPTR-HLPPAQMNTFPGSLPCFRAESPGSKLDGERD---KDKDSERKD--------RGEKAAVQEELAEEGGDS-DKNRIDSESGDELSSGSTDNLQSLG-SGQGRPDSPVYTNLQEMKISQSSTPPLPSSSPI-----------------HTNGDWETHKDQNGRHYYYNRSTQERTWK------------------------------PPR-ARDSL-----------------------------PRKEEKHDMTDTEVLSSEENCLS---SQSDSQYGSPPRGWSEEMDEHG---------------------------------------------------------------HTLYVCDYTN----EKWLRHTDE-----------------------RGRLYYYSADGSRSEWELPKIGLKSQSNHTP-------------LMPGDLHKTRSL------------------------------------------------------------------------------------DRRLPDPIPISRTQRHSIYSHETNDKLKQKFVKVRQSFLPRRKTTLRSHPYFPQDTKTGSPDSDSSCPSSPKPPHSPSEKCATLNMTK--------ITEHGKKVRKNWTSYWTVLQGSLLIFNKGQGGG-------SGW------------------------------------------------------FGRDQKSSVEYSVDLKGGSVDWASKDKSSKK-----------------------------------------------HVLELKTRQGTELLLQSDSDGLVN-----------DWHKALTEAIHTYMWESDEAIEEDMPESP---------ENEKHDKEKDRKNSKKARD-----------------------------IKKTASMDNAEQKK-KNKLVVLLLGRPTLQAVKDK-----------------------------------------------------------------GYIK--------DQVFGCSLSSLCQRENSTVPRFVWLCIEQVEKN--GLGVDGLYRVSGNLAIIQKLRFAVNHEEKID-------LGDSKWEDIHVTTGALKMFFRELPEPLFTYTFFSDFISAIKMP---------------------DYKQKVQTVKDLMKKLPRPNHDTIQVLFKHLKKVIQHVDENRMTTQSVAIVFGPTLLRPEIETANMAVHMVYQNQIVELILMEYDTIFGR-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q06407-1", "uniprot_id": "RGA2_YEAST", "id": "Q06407-1", "name": "Rho-type GTPase-activating protein 2", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSADPIN-DQSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGT----------LICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRG--LCCMDCHEKLLRKKQLLLE---------------------NQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQ-----ERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDS-----------------IVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNK-----------------ENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSR---------------------------------------------------PQTADNLLPHKKVAPSPN----KKLSRSFSL-----------------------KSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPV------------------------------------------------------------------------------------SRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLG-SISKKQNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSES--------AHHRSSSLQTSRSTNALLEDDSTKVDATDESATS----LEK-----------------------------------------------------DFYFTELTLRKLKLDVRELEGTKKKLLQDVENLR-----------------------------------------------LAKERLLNDVDNLTREKDKQSASSR------ESL-EQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPN-----------------------------SSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLS-----------------------------------------------------------------PSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIH-DFDGEKDIVDMKERNYIVEFILGNYRDIFKQA", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P39083-1", "uniprot_id": "RGA1_YEAST", "id": "P39083-1", "name": "Rho-type GTPase-activating protein 1", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASTAPN-EQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGA----------LICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRG--LFCLSCHEKLLAKRKYYEEK--------------------KRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSD--------IVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTP-----------LRNSSGQYLAKSPSSYRQGIIVNDSLEESDQ----------------------------IDPPNNSSRNASELLTSVLHSPVSVN------------MKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVP---------------------------------------------------DLAGVQQEQAEKYSYSNNSGKGRKISRSLSR-----------------------RSKDLMINLKSRATGKQDSNVKLSPASKVTSRR------SQDLMRDNDSHTGLDTP------------------------------------------------------------------------------------NSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSN---QNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDK-------------------------------------------------------EIVTAEHYLKQLKINLKELESQREELMKEITEMK-----------------------------------------------SMKEALRRHIESYNSEKNKLYLDSN------ELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAP-------------------VLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDA------------------------------------------------------------NMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQN---TETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIR-DFSGEKDIIDMKERNYIVAFIFGNYKDILT--", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P39960-1", "uniprot_id": "BEM2_YEAST", "id": "P39960-1", "name": "GTPase-activating protein BEM2/IPL2", "aln": "MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQTIRNSTSGASPYMHSHHHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIASTLKDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGTTLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSENYDTTVFKTGWVNKSHGQTVATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGNDVASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANENHQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSEVYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFPLLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVFPGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSSTHELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPLVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWLAVATIICSIPVLRSSSWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPNLDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHKTNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRSALVTGSYLPILFNELFPNYSLFPKNTLVGAASDAKLPPPRSSARLSKSLSISEPIPIASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNIDMDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLDTTGRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDTKDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIANSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFNTFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWIVLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNGTESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKNGSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGTQNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSITNSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAALHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIELR--GLDEVGLYRIPGSIGSINALKNAFDEEGATDN---SFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYK----------------AHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQDFIKNPNDYFKQ-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P38339-1", "uniprot_id": "RGD1_YEAST", "id": "P38339-1", "name": "RHO GTPase-activating protein RGD1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEETAKKPASATVS-----------------------------AKSSHDGGTDDLAHLFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIR----------KKYAFEEEHVQELSKQYKHFFNIQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKS-------------------VKENSKRLEKDVSDAIHSAEKAQSRYN------------------------------------------------------------------------------------SLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEE------------------------------------------------------------------------------ELLRKIDN-------------------------ADLEYKQKVDHSNSLRNTFITKER--------------------PRIVQELKDL-------------------------------------------------------------------------------------ILEIDTAMTIQLQKYTIWTEN---------------------LVLNTGVTISPLDSTKSMKSFAGSVSNER------DLYSFLNKYN-------QTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPP-------------------------------------------------------------------------KFAVDPSRNSIPKRMISTHNES-----------------------------------------------PFLSSSSNTAAVPNANLNSATPSLN-----------TNKQLPPTMASSISSTSNAAGAMSPSSS----------IVTSDTTSSITKTLDPGN-----------------------------NSPQIPEELINSLDSDRPISHIQTNNNMPPGVQKN-----------------------------------------------------------------------------FKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKF--GLDQEGIYRKSANVLDVSKLKEEIDKDPANIS--MILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIED---------------------PTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDAN---DVNFQIMAMEVLLEVSDQAFEPE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . . : . : . . . . . : : : . : . : . . . .. . . . . : : :. . . . : : :* * * :* :: : :: .: *:** ... :. :. . :: . :* : .**:.::. . : : :: ** .:: : *: :* * * :.:::. : : . : :: : ", "identical_positions": 16, "similar_positions": 91, "identity": "0.73%" }, { "cls_id": "homologset.agr.HGNC:16352", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZGI8-1", "uniprot_id": "D3ZGI8_RAT", "id": "D3ZGI8-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "----MTG---YPKLVGVPLKVRRLHTAVCHYKGRTGAEHLWLMRHLKDPFVKAAKAESYRCRSAFKLLEMNEKHHILR---PGLRVLDCGAAPGAWSQVAVQSVNATGADS---SSPMGFVLGVDLLHMFPLAG----------------------------------------------ATFLCPADVTDPRTFQRILELLPRRRADVILSDMAP---------------------NATGIRDLDHDRLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLAQEFRSTRVVKPEASRKESAEVYLLATQYHGRKGSTKQ----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CPY0-1", "uniprot_id": "MRM2_MOUSE", "id": "Q9CPY0-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "----MAG---HLKLVGVPLKVRRLHTAVCHYRGRTGAEHLWLTRHLKDPFVKAAKVESYRCRSAFKLLEMNEKHQILR---PGLRVLDCGAAPGAWSQVAVQRVNATGADS---SSPVGFVLGVDLLHIFPLAG----------------------------------------------ATFLCPADVTDPRTFQKILELLPSRRADVILSDMAP---------------------NATGIRDLDHDKLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLTQEFQSTRVVKPEASRKESSEVYLLATQYRGGKGTRRP----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UI43-1", "uniprot_id": "MRM2_HUMAN", "id": "Q9UI43-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "----MAG---YLKLVCVSFQRQGFHTVGSRCKNRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEVNERHQILR---PGLRVLDCGAAPGAWSQVAVQKVNAAGTDP---SSPVGFVLGVDLLHIFPLEG----------------------------------------------ATFLCPADVTDPRTSQRILEVLPGRRADVILSDMAP---------------------NATGFRDLDHDRLISLCLTLLSVTPDILQPGGTFLCKTWAGSQSRRLQRRLTEEFQNVRIIKPEASRKESSEVYFLATQYHGRKGTVKQ----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A421-1", "uniprot_id": "A0AB13A421_DANRE", "id": "A0AB13A421-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "----MWK---RIQRSCIHMSAVCLKKTPLHLKGKSTADKRWLIRQLSDPFVKAAHEQNYRCRSAFKLIEMDDKYRLLK---PGFTVIDCGAAPGAWSQVAVQRVNSTGESV---DLPKGSVIGIDILHIFPLDG----------------------------------------------AQFLTNHDITSPSTHTALERLLPEAGADVILSDMAP---------------------NASGFRELDHERLVSMCLSMLDLADKVLRPGGSLICKYWDGGLAHMLQQRLFSAFQDVRTVKPRASRKESAELFFLARMLKKR----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VDT6-1", "uniprot_id": "MRM2_DROME", "id": "Q9VDT6-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "MRLVFTGNCVFKRLLHTEIGGKYAKQQPRNLKGRSKSSQEWLTRQLADPYVEKARMMNYRCRSAFKLLEIDDKYGILR---PGDTVLECGAAPGSWTQVAVERTNANGKQE---RAPQGAVFSIDLLHFHAVPG----------------------------------------------ATIFGGMDFTSSLAQKRLREALQDRKVNCVLSDMAP---------------------NATGVRMLDQESITNLCYEVLRFALAMSAPQAHLVVKVWDNGDVPKLERDMLRFYEKVKRVKPRASRGDSAEHFLVARNFKGATDS-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53123-1", "uniprot_id": "MRM2_YEAST", "id": "P53123-1", "name": "rRNA methyltransferase 2, mitochondrial", "aln": "----------MILVYNRIRSIISSSLGRIHVRYNSNSQNRWLNRQLKDPYTKEAKVQNLRSRAAFKLMQIDDKYRLFSKNRTDQRILDLGYAPGAWSQVARQRSSPNSMILGVDILPCEPPHGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDDLHKDHGYFQNMLEEELTHVKDTELYREIFTSDDIYETPNTNSTLIEREKFPVDVIISDMYEPWPQTTGFWNNITNQAYFRMANTSGVSIRDHYQSIDLCDAALVTAIDLLRPLGSFVCKLYTGEEENLFKKRMQAVFTNVHKFKPDASRDESKETYYIGLKKKRNVDKLDVFSNS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : .: :.: ** *:* **:.: *: . *.*:****::::::: :: .. ::: * ***:*:*** : .. . * .:: :: : :: *. .. .: ::*** *::*. *: .:* : : : * . :: * : . ::: : : ..: .** *** :* * : :. : ", "identical_positions": 39, "similar_positions": 78, "identity": "11.82%" }, { "cls_id": "homologset.agr.HGNC:16353", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9UNF1-1", "uniprot_id": "MAGD2_HUMAN", "id": "Q9UNF1-1", "name": "Melanoma-associated antigen D2", "aln": "MSDTSESGAGLTRFQAEASEKDSSSMMQTLLTVTQNVEVPETPKASKALEVSEDVKVSKASGVSKATEVSKTPEAREAPATQASSTTQLTDTQVLAAENKSLAADTKKQNADPQAVTMPATETKKVSHVADTKVNTKAQETEAAPSQAPADEPEPESAAAQSQENQDTRPKVKAKKARKVKHLDGEEDGSSDQSQASGTTGGRRVSKALMASMARRASRGPIAFWARRASRTRLAAWARRALLSLRSPKARRGKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIKRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFG-DVKKLITDEFVKQKYLDYAR--VPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRARMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAEAKAKAQES----------GSASTGASTSTNNSAS--ASASTSGGFSAGASLTATLTFGLFAGLGGAGASTSGSSGACGFSYK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q3B7U1-1", "uniprot_id": "Q3B7U1_RAT", "id": "Q3B7U1-1", "name": "Melanoma-associated antigen D1", "aln": "MSDTSESGADPARSQGKASEKDSGSMMQDLLTVTQNLEVSETPKAKKAPEVSEAAKVPKASGNPKATEVSKAPEASEAAATQASPTTQLSETQVLAAENKSPAADTKTQKADLQAMTMPATQTKTVSSVTDSKVNTKTPETEAPASQSGADEPEPEGAAVQVQENQDTRPKVKAKNTEKGKHLEGEEDGNSDQSQTSETTGGRRVSKALMASMARRASRGPIAFWARRASRTRLAAWARRALLSLRSPRARRGKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIRRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFG-DVKKLITDEFVKQKYLDYAR--VPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRAQMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAETKAKAQESSGASAGTGAGASASAGTSVSTSGTAGSGANAGASGGFSTNPSLTASLTFGLFAGLSGAGASNSSSSGACGFSYK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9I7L4-1", "uniprot_id": "Q9I7L4_DROME", "id": "Q9I7L4-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASTSR----------------------------------------AARSQNAIPSQEAQQP----VDVVDAKVRAILNYILDHTAQKIPIKDKDLIA--VAGDKSELKKRLPLVTNLLAETFGIILTPLDATTKTFICT-AEEPVASIHELTPAQRPQFTLLYIILMYIFLRGNRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQYLKRERSQLSAYDDSKTFFLWGPRAKAEFTFEQMVQFASKLLNQHPKVFGHHLSMAQEG---VNAE----------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** :* *: : .***.: * * :::.:.. :::*:* : ****: .*:: : .. : : . * :.*** *. :* . : :* : **. : *. : *:: ** ::* **:.*** .:: :: :*. *.: *. .*. ** :::* * : ****:**. * :. : .: *:** *: * : ::::**.*: ::.** :. : * *. . ** ", "identical_positions": 65, "similar_positions": 86, "identity": "10.47%" }, { "cls_id": "homologset.agr.HGNC:16354", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4QQW3-1", "uniprot_id": "HOT_RAT", "id": "Q4QQW3-1", "name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "aln": "MAAAARARVTHLLRHLQSTACQCPTHSHTY-SQVPGLSPSGKTTDYAFEMAVSNIRYGAGVTKEVGMDLQNMGAKNVCLMTDKNLSQLPPVQIVMDSLSKNGISFQVYDNVRVEPTDGSFMDAIEFAKKGAFDAYVAVGGGSTMDTCKAANLYACSPHSEFLDYVNAPIGKGKPVTVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKTGIASRAIKPTLGLVDPLHTLHMPCQVVANSGFDVLCHALESYTAIPYSMRSPCPSNPIQRPAYQGSNPISDIWAVHALRIVAKYLKRAVRNPDDLEARSSMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKTYKAKEYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLETAEILGANIRTAKIQDAGPVLADALRKFLFDLNVDDGLAALGYSKDDIPSLVKGTLPQERVTKLAPRAQSEEDLSALFEASMKLY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R0N6-1", "uniprot_id": "HOT_MOUSE", "id": "Q8R0N6-1", "name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "aln": "MAAAARARVTHLLRHLQSTACQCPTHSHTY-SQAPG--PSGKTADYAFEMAVSNIRYGAGVTKEVGMDLQNMGAKNVCLMTDKNLSQLPPVQIVMDSLSKNGISFQVYDDVRVEPTDGSFMDAIEFAKKGAFDAYVAVGGGSTMDTCKAANLYASSPHSEFLDYVNAPIGKGKPVTVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKTGIASRAIKPTLGLVDPLHTLHMPCQVVANSGFDVLCHALESYTAIPYSMRSPCPSNPIQRPAYQGSNPISDIWAVHALQIVAKYLKRAVRNPDDLEARSKMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKTYKAKEYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLETAGILGANIRTARIQDAGLVLADALRKFLFDLNVDDGLAALGYSKDDIPSLVKGTLPQERVTKLAPRAQSEEDLSALFEASMKLY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IWW8-1", "uniprot_id": "HOT_HUMAN", "id": "Q8IWW8-1", "name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "aln": "MAAAARARVAYLLRQLQRAACQCPTHSHTY-SQAPGLSPSGKTTDYAFEMAVSNIRYGAAVTKEVGMDLKNMGAKNVCLMTDKNLSKLPPVQVAMDSLVKNGIPFTVYDNVRVEPTDSSFMEAIEFAQKGAFDAYVAVGGGSTMDTCKAANLYASSPHSDFLDYVSAPIGKGKPVSVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKIGITSRAIKPTLGLIDPLHTLHMPARVVANSGFDVLCHALESYTTLPYHLRSPCPSNPITRPAYQGSNPISDIWAIHALRIVAKYLKRAVRNPDDLEARSHMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKMYKAKDYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLEMAEILGADTRTARIQDAGLVLADTLRKFLFDLDVDDGLAAVGYSKADIPALVKGTLPQERVTKLAPCPQSEEDLAALFEASMKLY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W265-1", "uniprot_id": "HOT_DROME", "id": "Q9W265-1", "name": "Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial", "aln": "---MSRKNVLGLINTIVANSCKCPAHSHNYGSAAPTASQTGR-MEYAFEMSASTVRFGPGVSAEVGADLRNLGARKVCLVTDKNVVQLPSVKVALDSLARNGINYEVYDETRVEPTDGSMWHAVEFARGKEFDAFLAIGGGSAMDTAKAANLFSSDANAEFLDYVNCPIGRGKEISVKLKPLIAMPTTSGTGSETTGVAIFDYKKLHAKTGISSKFLKPTLAVIDPLHTLSQPQRVMAFAGFDVFCHALESFTAVDYRERGLAPSDPSLRPTYQGRNPVSDVWARFALETIRKNFVNAIYQPDNLEARSQMHLASTMAGVGFGNAGVHLCHGLSYPISGNVRDYKPKGYSADHALIPHGLSVVISAPAVFEFTAPACPDRHLEAAQLLGAEVRGVEKADAGRLLADTVRGFMQRAGIENGLRELGFSSSDIPALVEGTLPQERITKLAPRAQTQENLSQLFEKSMEVY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P10127-1", "uniprot_id": "ADH4_YEAST", "id": "P10127-1", "name": "Alcohol dehydrogenase 4", "aln": "----------------MSSVTGFYIPPISF--------------------------FGEGALEETADYIKNKDYKKALIVTDPGIAAIGLSGRVQKMLEERDLNVAIYDKTQPNPNIANVTAGLKVLKEQNSEIVVSIGGGSAHDNAKAIALLATN-GGEIGDYEGVNQSKK-----AALPLFAINTTAGTASEMTRFTIISNEEKKIKMAIIDNNVTPAVAVNDPSTMFGLPPALTAATGLDALTHCIEAYVST-------------------ASNPITDACALKGIDLINESLVAAYKDGKDKKARTDMCYAEYLAGMAFNNASLGYVHALAHQLGG-------------FYHLPHGVCNAVLLPHVQEANMQCPKAKKRLGEIALHFGASQEDPEET----IKALHVLNRTMNIPRNLKELGVKTEDFEILAEHAMH-DACHLTNPVQFTKEQVVAIIKKAYEY-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .: :* .. *.. ::* . ::. ::** .: : . . * ...: :**..: :*. ... .::. : : :::****: *..** * : . .:: ** . .: **:*: **:**.** * .:*:. :. : * .* .. :.*::.: ** : * : * :*:*.: *.:*::.: . **::* * .: : : : * : .: :**: * *. :**:.*.**.: *.::: :.* . :***:. .: * * . :: * :: .::: : .: .* :* .. *: *.: :: : * ::*:: ::: : : ", "identical_positions": 69, "similar_positions": 149, "identity": "14.74%" }, { "cls_id": "homologset.agr.HGNC:16356", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZTY5-1", "uniprot_id": "D3ZTY5_RAT", "id": "D3ZTY5-1", "name": "", "aln": "MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKMQRKHHERMERRYRRELAER--SDTLSFSSLTSSTLSRRLQHMTLGSQLPYSQATLHGTAKGKAKIQKKLERRKQGVEGTFKVSEDGRKSVRSLSGLQLGNDVMFVRQGTYANPKEWG--RAPLRDMF----------LSD-EDSVSRAT-----LAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYVSSGLHGLG-REDGGLDGAG-TPRGR---LHS-----SPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDED---LEPETSPLETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQALERPLALEDTEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80T11-1", "uniprot_id": "USH1G_MOUSE", "id": "Q80T11-1", "name": "pre-mRNA splicing regulator USH1G", "aln": "MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKMQRKHHERMERRYRRELAER--SDTLSFSSLTSSTLSRRLQHMTLGSQLPYSQATLHGTAKGKAKIQKKLERRKQGGEGTFKVSEDGRKSVRSLSGLQLGSDVMFVRQGTYANPKEWG--RAPLRDMF----------LSD-EDSVSRAT-----LAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYVSSGLHGLG-REDGGLDGAG-TPRGR---LHS-----SPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDED---LEPETSPLETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQALERPLALEDTEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q495M9-1", "uniprot_id": "USH1G_HUMAN", "id": "Q495M9-1", "name": "pre-mRNA splicing regulator USH1G", "aln": "MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAER--SDTLSFSSLTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKSARSLSGLQLGSDVMFVRQGTYANPKEWG--RAPLRDMF----------LSD-EDSVSRAT-----LAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLG-REDGGLDGVG-APRGR---LQS-----SPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDED---LEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RQW2-1", "uniprot_id": "A0A8M1RQW2_DANRE", "id": "A0A8M1RQW2-1", "name": "", "aln": "MNDKYHKAARDGYLDLLKEATRKDLNAPDEDGMTPTLWAAYHGNLDALRLIAGRGGNPDKCDIWGNTPLHLAASNGHLNCLSFLVSFGANVWCLDNDYHTPLDMAATKNHMDCVRYLDSIAAKQTALNPKLVSKLKDRAFRDAERRIKECVKLQQRHRRRMERKFQREATEASVSDAMSFSSYASSTLSRKLHHFNTATNVPYSQATIHATARGKTKIQKKLEKKKQG-DGTFKIYEDGRKSVRSLSGLQLGNDVMFLKQGTYVNPKDRS--RRNIRDMF----------PSDNEDAISRAISEPDLHGQDVDYSEISTDSGHDSLFNRPGLGTMVFRRNYVSGGLFGIGSRDEGSLTGSERVDNVR---LQNRM---HPSLDDDSIGSAHSLQERNI-QELPWDEVELGLDDD---DEPDTSPLEVFLATQSMNEFIPILKREKIDLDALLLCSDNDLKGIHIPLGPRKKIMDACMRRLETLEEPGPIEDTEM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7T6J6-1", "uniprot_id": "A0A8N7T6J6_DANRE", "id": "A0A8N7T6J6-1", "name": "", "aln": "MDDRFHRAARDGHLLLLKEATRKHLNAPDEDGMTPTLWAAQHGNVDALRLIVGRGGDPDKCDIWGNTPLHLAAANGHLSCLSFLVSFGANVWCLDNDYHTPLDMAASRSHMDCVRYLDSIAAKQITINPKLVSKLKERGFRNAEKRIRNCEKLQRKHHQRMERHFMRESAALDTSDTMSYSSFSS-TLSRRMPQFNTLDSMTYSQATLQSTARGRTKIQRKLEKKKQV-EGTFKISEDGRKSVRSLSGLQLGNDVMFLKQGTFVDRRHQSSPRLNIRNMFSGKSDIRLEDVDDEEDTVSRALSDP--GLYEAAYSEISTDSGRDSLFNRPGLGTMVFRRNYATDGVFRTG-RGEGSVAGSEPVGRAPNIHLRGRLPLRSPSLDEVSIGSSLSLQEKNL-QDLPWEEGDLGLEEEDDELQPSSAPLEVFLASQGLSDYVSIFQREQMDLEALLLCSEQDLISIHIPLGPRKKLLDACRRRNSVMEEAEGMLDTTL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:*::*:*****:* ********.**************** ***:::****..***:****************:**** ***********:*************** :.**:************ ::*****.***::.**:**:**::* *:*::*:.****:: ** : **::*:** :* ****:: :: :.*****::.**:*::*:*:***::** :****: ******.*********.****::***:.: :. . * :*:** .* **::*** : :**:*****:****.************* :.*:. * * :*.: * . . *:. ****: *:**: ***::. ::***:* :***::: :*.::***.***: :.:: .::::*::**:**:***: ** .* :*******::.* ** ..:*.. : ** :", "identical_positions": 266, "similar_positions": 133, "identity": "53.85%" }, { "cls_id": "homologset.agr.HGNC:1636", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AC58J1X9-1", "uniprot_id": "A0AC58J1X9_DANRE", "id": "A0AC58J1X9-1", "name": "", "aln": "---MMYLVLAVCILSASVFSQSGSHSLWVFATFLTGDISVQFPEFSAVVMLDDIVIGHYNADDRSFVPSTVQESVNIT-EQITISTVCKGIHEGMKTKAYYLIDYLNHTRGLHVQQRLVGCELLQNEPGQMMTLEAFNGE--SGFERRYDIQGDQQTHWKWPVIKSR-AQLEYDAWLYAHFYRPLCINQLRKYLKKEKKRVMARVKPRVRVIQRTCSKTGKIQMTCLATGFYPRHINLTLLQDGQPVNEERVMGGELLPNADGTYQMRKSVELSAEEQRERRTYTCTVNHLSLDNKLDISIEPGLDPVIIFPSVLLLLCVFGVLAGFLMWRKKYKQPEQVHKHFHCFTDKLIFIRYKHCSLRFLIVFLPLQVTYTPTSATDQTTEQSQL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P29017-1", "uniprot_id": "CD1C_HUMAN", "id": "P29017-1", "name": "T-cell surface glycoprotein CD1c", "aln": "MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFS-FVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQ--EQLGTKHGDILPNADGTWYLQVILEVASEEPAG---LSCRVRHSSLG-GQDIILYWGHHFSMNWIALVVIVPLV-ILIVLVLWFK------------------------KHCSYQDIL------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :*:**: : ... . * .* : . ::: :. .:.. .. **:: ::::. ::: .. *:: *::: : :: *: :::: . * .**** ..:. : : **** .*:. : . .* : * * : :: *. * . * *. * * :*:*.. : .*.. :*:: :.* *:****: : :* ::: * :: . *::*******: :: :*:::** :* *.* **. ** : * . : : :::::: :. :* :::* * **** : :: ", "identical_positions": 67, "similar_positions": 123, "identity": "17.22%" }, { "cls_id": "homologset.agr.HGNC:16361", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q810W9-1", "uniprot_id": "WHRN_RAT", "id": "Q810W9-1", "name": "Whirlin", "aln": "-----------------------------------------------------MNAQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSEPEREQFTHCLNAYHARRN----------------VFDLVRTLRVLLDSPV------KRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYR-------------QPAWAA-----------------PDGAG---------------------------PGEVRLVSLRRAKAHE------------------------GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVK----ALKGSKKLVLSVYS------------AGRIPGGYVTNHIYTWVDPQGRSTSPPS-SLP--HGSTLRQ----HEDDRRSALHLLQSGDEK--------KVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLK-----------------------------VGDQILEVNGRSFLSILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESITNS---AGFPGDLTEEGTNKPGFYKGPAGSQVTLSSLGNQTRALLDDQARHLLTEQERATMMYYLDQYRGGTISVEALVMALFELLNTHAKFSLLSEVRGIISPQDLDRFDHLVLRREIESMKARQPPGPG---------VGDTYSMVSYSDT-GSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTCETTQGSTNALPDVSVDDVRSPSEDLPGIKPPPPPPPLAQGHDRLLGQTRKPVRED---SAPLSSA-AHSGIVFSAPRNRSPPPPPGIAPTPTPGPSSARDSPS------------------------------------SPIYASISHANPSSRKPLDTHLALVNQHPIG------------PFPRVQSP-----------------------------------------------------------------------------------------------------PHLKSPPAEAPGAGACLPPPSPSEHADAMG--ANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSE-DSGVDAGETE-ASTSGRGRQTANTKNKNGKELPQTERTTEGANKPPGLLEPTSTLIRVRKSAATLGIAIEGGANTRQPLPRIVTIQRGG------SAHNCGQLKVGHVILEVNGQTLRGKEHREAARVIAEAFKTKERDYIDFLVTEFNVML------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80VW5-1", "uniprot_id": "WHRN_MOUSE", "id": "Q80VW5-1", "name": "Whirlin", "aln": "-----------------------------------------------------MNAQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSEPEREQFTHCLNAYHARRN----------------VFDLVRTLRVLLDSPV------KRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYR-------------QPAWAA-----------------PDGAG---------------------------PGEVRLVSLRRAKAHE------------------------GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVK----ALKGSKKLVLSVYS------------AGRIPGGYVTNHIYTWVDPQGRSTSPPS-SLPQPHGSTLRQ----REDDRRSTLHLLQSGDEK--------KVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLK-----------------------------VGDQILEVNGRSFLNILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESVANS---AGFPGDHTEEGTSKPGFYKGPAGSQVTLSSLGNQTRALLDDQARHLLTEQERATMMYYLAQYRGGTISVEAMVMALFELLNTHAKFSLLSEVRSIISPQDLDRFDHLVLRREIESMKARQPPGPG---------VGDTYSMVSYSDT-GSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTGETTQGSTNALPDVSVDDVKSPSEDLPGIKPPPPPPPLAQGHDRLLGQPRKPGRED---PAPLSSA-AHSGIVFSAPRNRSPPP----GTAPTPGPSSAQDSPS------------------------------------SPIYASISHANPSSRKPLDTHLALVNQHPIG------------PFPRVQSP-----------------------------------------------------------------------------------------------------PHLKSPPAETPGAGACLPPPSPSEHPDAVG--ANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSE-DSGVDAGETE-ASTSGRGRQTASAKNKNGKEQPRTERTAEGANKPPGLLEPTSTLVRVRKSAATLGIAIEGGANTRQPLPRIVTIQRGG------SAHNCGQLKVGHVILEVNGQTLRGKEHKEAARIIAEAFKTKERDYIDFLVTEFNVML------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P202-1", "uniprot_id": "WHRN_HUMAN", "id": "Q9P202-1", "name": "Whirlin", "aln": "-----------------------------------------------------MNAPLDGLSVSSSSTGSLG-SAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTHCLNAYHARRN----------------VFDLVRTLRVLLDSPV------KRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYR-------------QPAWGG-----------------PDSAG---------------------------PGEVRLVSLRRAKAHE------------------------GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVK----ALKGSKKLVLSVYS------------AGRIPGGYVTNHIYTWVDPQGRSISPPS-GLPQPHGGALRQ----QEGDRRSTLHLLQGGDEK--------KVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLK-----------------------------VGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANS---AGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESMKARQPPGPG---------AGDTYSMVSYSDT-GSSTGSHGTSTTVSSARN-----------TLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGRED---LQPPSSMPSCSGTVFSAPQNRSPPA----GTAPTPGTSSAQDLPS------------------------------------SPIYASVSPANPSSKRPLDAHLALVNQHPIG------------PFPRVQSP-----------------------------------------------------------------------------------------------------PHLKSPSAEATVAGGCLLPPSPSGHPDQTG--TNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSE-DSGVDAGEAE-ASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGG------SAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IAF3-1", "uniprot_id": "A0AC58IAF3_DANRE", "id": "A0AC58IAF3-1", "name": "Whirlin", "aln": "-----------------------------------------------------MSTDLERLSLNSSSGNSVASSARS-----------LSANVKKLHNALNLLLSDLEREQFIHCLNVYHSKRN----------------VYDLVQTLKVILNVPS------KRQLLPMLRLVIPRSDQLLFDQYTSEGLYLKSEIHARNGDPDGAQEGANSSPTHGANF-----PASQVALRGSPDSISTSS------DGTATLIPLLGRNFLPEPPGEIRQVILKRHKSNE------------------------GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRMGDQIMKVNDKVFDRVTHADAVK----VLKGSKKLCMSVRS------------VGRIPGGYITNHVYTWVDPQGRSVSPPPDLLAEHRSATLRR----SNSQGRSHMQLLQDGDEK--------KVNLVLDDGRSLGLMIRGGAEYSLGIYITGVDRGSAAECGGIKTVPSPASSRPALPPPAHTPSPVCPPSCPQVGDQILEVNGRSFLSIPHDEAVRVLKSSHHLMMTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSV-TGISLDQGASTSAKGGFYKGVAGSQVTLSSLVNQSRAMLEEQARHLLTEPERQTMGYYIQEYRDGHVGVEQLVMALFELFNTHAKFSLLSEVRGIVTPQDVEKFDGLVLRREIDALKARQGGGAG---------FQDSFSMVSYPDTLASSSASFMTNTTLSSARN----------DGVAENNGEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPPPPG--------LQRRPSRKATLS---KRPSSSS-SQSGLYFTAP-SRSHTR-----ESKHPKAPKAFMSPP------------------------------------GTLKIDVPAS----------QLSVVSQHPIG------------PFPRVQSPNKAKPAQSSSPIPP-------------------------------------------------------------------------------------PAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHFVMVEVHRPNAEPDVNEVRPLPQVRGG-TLSQLSDSGQTLSE-DSGVDIPE------SGRLSKDTSPRPARTRAPRDGHGGGETSAKPPGLLEPMSTLVRVAKSASTLGIAIEGGANTRQPLPRIVTIQRGG------SAHNCGQLKVGQVILEVNGVSLRGKEHREAARLIAEAFKTKEKDYIDFLITEFNVAL------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9P8V0-1", "uniprot_id": "A0A8M9P8V0_DANRE", "id": "A0A8M9P8V0-1", "name": "", "aln": "-----------------------------------------------------MSTDLERASLKSG-ANSLGSGGRT-----------LSVNVKKLHNALNVLLNDFEREQFIHCLNVYHAKRN----------------VFDLVQTLKVILNTPH------KRQLLPMLRLVIPRSDQLLFDQYTSEGLYLKTDLLAASVKHECSEDLSSTNAHAGAS---------SVHFAPQSDQAGPSHGSLRPASVFSTSAEGTAPALMLEAPSEIRQVTLKRSKSHE------------------------GLGFSIRGGSEHGVGIYVSLVEPGSSAEREGLRVGDQIMKVNNVVFDRVTHGEAVK----VLKGSKKLSMSVCS------------MGRIPGGYVTNHVYTWVDPQGRSVSPPP--------DLVEQ----HSLGGR--LSDLHTNTEK--------KVNISLDDGRSLGLMIRGGAEYALGIYITGVDRGSAAEYSGLK-----------------------------VGDQILEVNGRNFRSICHDEAVQILKNSRHMLMTIKDVGRLPHARTVVDETKWIPSAQIAESSANSNSQSILSVDVGTGSLGKSVCCKGVVP---AVGAVRAGAWSSLEEQAFMLLTETERQTMSYYIQEYQRAHIGVEPLAMALFELFNTHAKLSLLAEVRTLVAPQDLERFDGQVLLREMEAWRARHGGQGL---------LHPDSICITQPEGLVPSPACQMNTGGSGYSKS-----------ECRLDG-SLMPLETLNSLPDVALDKVQVSSESPPSFKPPPPPIRHASPKTQTKRPSSKLSQTNLFFTAPFRRHQENHTLNHSHLSCSSHTSPCTIHHTTSPCSISHTPPPCS--------------------------------HHHSSPRTSSYHSSPSSGRDLVQFLMNRQAGTLS------------PHPESPNRSRD-------------------------------------------------------------------------------------------------GTPMISPRSSPSLSPSLLMPAPPPCSPERLD----GSPSTHSCGPQHAEPETTEDRPQPQLRGA-TLSQLSDSGQTLSE-DSGVDIAEAGGLSKDSSPRPGKPPFQQFTGDTRRAEGLAQATAKQMGMMEP--ILVRVPKCASTLGIAVEGGANTRQPLPRIATIQKGG------SVHLCGQLRVGQVILEVNGVSLKGMEHRDATRLIAEAFKTKDKDHVDFLIMEFNSAL------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9PF56-1", "uniprot_id": "M9PF56_DROME", "id": "M9PF56-1", "name": "", "aln": "MRLGGSGIPYDGDPLTMSAAGNDYAELCDLGPSRWSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMAFGMISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLM-----------------------------IGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRK-----------------------------------GQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTADDLEIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEAXHLLALPASDPLERQKLEFLYEWGIDLTETPKPMPTPIPLTKAKNPPPLPHELHNNINSQYGSSAALSNHQPHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTGTGAATTGSKQQQQPGNTTNTPTKASREATPTREQHHQHATPTREHQQQTPTRQQQLQREQQQQLQREQQQQHHRDRQQHFREQREQREREYQHEHEHEQHHHHHHHREHHEQHQHQHGHQHHPQHQHHHQYSSQQQHQRYSSSNSYKSHNNSVYQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. : . .*. . . . * :...: *: : : . . . * :. * .::: * : :* :* .. :.. .:. : : . . . *. : : * : .: *:*:.::**.: *:*:*:* :* .* **: *** ** *:.**. : :.* :*:* **.*::: ::* : * . . : : . :.**.:: :... ..: . * :. . .: :*:: : *:**** ****.**.***::**** .* *: .*: :**:******:.* .: ***** ** ::: :.::***::**: * : * . : . ::::* ** . . :: **: :* : :: :. .*:::::*: * :*::*:* : *:* ::* * ** :. . : : .... . . .. ::. : .: :* . : . : * . . . . : . .: * *. . . * . *.. . . . ... : * : . * : ::*.:* . :*.. . . : : : : : : * : :: : *: * * : : * : : *:. .: . :.:::: : : ", "identical_positions": 121, "similar_positions": 249, "identity": "9.18%" }, { "cls_id": "homologset.agr.HGNC:16364", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A7B5-1", "uniprot_id": "D4A7B5_RAT", "id": "D4A7B5-1", "name": "", "aln": "MASSGRLGFTVRSLLNLPEQDAQPRVRCEQQTCVPQT---AAWLESERSHYPSSDESGLETSPADSSQLASLGRASPGSDAEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGVTESSDVTASADLHAAPGLLRRVVVPVLVHDRSPCN----GRGEGTAAVPQDKCSSRLATACPVQGYTAFGPGSALGLFPAYQHLAPPALVSWNW---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O70584-1", "uniprot_id": "NKX28_MOUSE", "id": "O70584-1", "name": "Homeobox protein Nkx-2.8", "aln": "MATSGRLGFTVRSLLNLPEQDAKPRVRREQQTCVPQT---AAWLESECSHYLSSDESGLETSPADSSQLASLRRESPGSDPEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGITEPSDMAASSDLHAAPGLLRRVVVPVLVHDRPPSNN---GRGEGTSAVPQDKCSARLATACPVPGYTAFGPGSALGLFPAYQHLAPPALVSWNW---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15522-1", "uniprot_id": "NKX28_HUMAN", "id": "O15522-1", "name": "Homeobox protein Nkx-2.8", "aln": "MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGG--GGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P8T3-1", "uniprot_id": "A0A8M9P8T3_DANRE", "id": "A0A8M9P8T3-1", "name": "", "aln": "MAISNKFSFTVRSILDLPENDTESIVQHSPLDSFSVS-PYSTWTENDRGH-ISSDDSNIEASP-DSTEPDVL---SVDTEHEKRKKRRVLFSKAQTYELERRFRQQRYLSAPEREQLAHLLRLTPTQVKIWFQNHRYKMKRAR---------IECAQDLNQPP-VLRRVVVPILVRDGKPYQNCTIDTEKGNGIVPP----TVPSSPFTVQGFHSLQQQTPFALFPTYQHFTNTAASRHHFCVW", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** *.::.*****:*:***:*:: : . . . ::* :.: .* ***:*.:*:** **:: * .:: ***:*********** ********************* *******************:**.* : .: :*: .* :*******:**:* * . : .. : ::. .: *: :: :.:.***:***:: .* :: ", "identical_positions": 103, "similar_positions": 63, "identity": "42.21%" }, { "cls_id": "homologset.agr.HGNC:16369", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88767-1", "uniprot_id": "PARK7_RAT", "id": "O88767-1", "name": "Parkinson disease protein 7 homolog", "aln": "---------------------------MASKRALVILAKGAEEMETVIPVDIMRRAGIKVTVAGLAGKDPVQCSRDVVICPDTSLEEAKTQGPYDVVVLPGGNLGAQNLSESALVKEILKEQENRKGLIAAICAGPTALLAHEVGFGCKVTSHPLAKDKMMNGSHYSYSESR-VEKDGLILTSRGPGTSFEFALAIVEALSGKDMANQVKAPLVLKD--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99LX0-1", "uniprot_id": "PARK7_MOUSE", "id": "Q99LX0-1", "name": "Parkinson disease protein 7 homolog", "aln": "---------------------------MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVMICPDTSLEDAKTQGPYDVVVLPGGNLGAQNLSESPMVKEILKEQESRKGLIAAICAGPTALLAHEVGFGCKVTTHPLAKDKMMNGSHYSYSESR-VEKDGLILTSRGPGTSFEFALAIVEALVGKDMANQVKAPLVLKD--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99497-1", "uniprot_id": "PARK7_HUMAN", "id": "Q99497-1", "name": "Parkinson disease protein 7", "aln": "---------------------------MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENR-VEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5XJ36-1", "uniprot_id": "PARK7_DANRE", "id": "Q5XJ36-1", "name": "Parkinson disease protein 7 homolog", "aln": "---------------------------MAGKRALVILAKGAEEMETVIPVDVMRRAGIAVTVAGLAGKEPVQCSREVMICPDSSLEDAHKQGPYDVVLLPGGLLGAQNLSESPAVKEVLKDQEGRKGLIAAICAGPTALLAHGIAYGSTVTTHPGAKDKMMAGDHYKYSEAR-VQKDGNVITSRGPGTSFEFALTIVEELMGAEVAAQVKAPLILKD--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z9J4-1", "uniprot_id": "DJ1A_DROME", "id": "A1Z9J4-1", "name": "Protein DJ-1alpha", "aln": "MLSVLRKSFPNGVTHAHRVIRCKSNQDKCAKNALIILAPGAEEMEFTISADVLRRGKILVTVAGLHDCEPVKCSRSVVIVPDTSLEEAVTRGDYDVVVLPGGLAGNKALMNSSAVGDVLRCQESKGGLIAAICAAPTALAKHGIGKGKSITSHPDMKPQLKE--LYCYIDDKTVVQDGNIITSRGPGTTFDFALKITEQLVGAEVAKEVAKAMLWTYKP", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VA37-1", "uniprot_id": "DJ1B_DROME", "id": "Q9VA37-1", "name": "Protein dj-1beta", "aln": "----------------------------MSKSALVILAPGAEEMEFIIAADVLRRAGIKVTVAGLNGGEAVKCSRDVQILPDTSLAQVAS-DKFDVVVLPGGLGGSNAMGESSLVGDLLRSQESGGGLIAAICAAPTVLAKHGVASGKSLTSYPSMKPQLVN--NYSYVDDKTVVKDGNLITSRGPGTAYEFALKIAEELAGKEKVQEVAKGLLVAYN-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .* **:*** ****** *..*::**. * ****** . :.*:***.* * **:** :. . . :***:**** * : : :*. * ::*: **. ********.**.* * :. * .:*::* * :: * * : : * :** ::*******:::*** *.* * * : . :* :: ", "identical_positions": 82, "similar_positions": 51, "identity": "37.44%" }, { "cls_id": "homologset.agr.HGNC:1637", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P11609-1", "uniprot_id": "CD1D1_MOUSE", "id": "P11609-1", "name": "Antigen-presenting glycoprotein CD1d1", "aln": "MRYLPWLLLWAFLQVWGQSEAQQKNYTFRCLQMSSFANRSWSRTDSVVWLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSAGCEMYPGNASESFLHVAFQGKYVVRFWGTSWQTVPGAPSWLDLPIKVLNADQGTSATVQMLLNDTCPLFVRGLLEAGKSDLEKQEKPVAWLSSVPSSADGHRQLVCHVSGFYPKPVWVMWMRGDQ--EQQGTHRGDFLPNADETWYLQATLDVEAGE---EAGLACRVKHSSLGGQDIILYWDARQAPVGLIVFIVLIMLVVVGAVVY------------------------YIWR-RRSAYQDIR----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P11610-1", "uniprot_id": "CD1D2_MOUSE", "id": "P11610-1", "name": "Antigen-presenting glycoprotein CD1d2", "aln": "MRYLPCLLLWAFLQVWGQSEVQQKNYTFRCLQTSSFANISWSRTDSLILLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSTGCEMYPGNASESFFHVAFQGKYAVRFRGTSWQRVLGAPSWLDLPIKVLNADQGTSATVQTLLNDTWPQFARGLLEAGKSDLEKQEKPVAWLSSVPSSAHGHLQLVCHVSGFYPKPVWVMWMRGDQ--EQQGTHRGDFLPNADETWYLQATLDVEAGE---EAGLACRVKHSSLGGQDIILYWDARQAPVGLIVFIVLIMLVVVGAVVY------------------------YIWR-RRSAYQDIR----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63493-1", "uniprot_id": "CD1D_RAT", "id": "Q63493-1", "name": "Antigen-presenting glycoprotein CD1d", "aln": "MLYLPCLLLWAFPQFWGQSEVQQ-NYTFGCLQISSFANRSWSRTDSVVWLGDLQTHRWSNDSDTISFTKPWSQGKFSNQQWEKLQHMFQVYRTSFTRDIKEIVKMMSPKEDYPIEVQLSAGCEMYPGNASESFLHVAFQGEYVVRFHGTSWQKVPEAPSWLDLPIKMLNADEGTRETVQILLNDTCPQFVRGLLEAGKPDLEKQEKPVAWLSRGPNPAHGHLQLVCHVSGFHPKPVWVMWMRGDQ--EQGGTHRGDILPNADETWYLQATLDVEAGD---EAGLACRVKHSSLEGQDIILYWGGRQVSPVLIFLIVGVLVLVVCAVAY------------------------YIIRKRRRSYQDIM----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P15813-1", "uniprot_id": "CD1D_HUMAN", "id": "P15813-1", "name": "Antigen-presenting glycoprotein CD1d", "aln": "MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSNDSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLS--YPLELQVSAGCEVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLLNGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMRGEQ--EQQGTQPGDILPNADETWYLRATLDVVAGE---AAGLSCRVKHSSLEGQDIVLYWGGSYTSMGLIALAVLACLLFLLIVGF------------------------TSRFKRQTSYQGVL----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N5I1-1", "uniprot_id": "A0A8M1N5I1_DANRE", "id": "A0A8M1N5I1-1", "name": "", "aln": "--------------------------MALATYIVG--QTPFPEFSVVVMLDDLQLAYYDSIG-WKTIYRSGSDSKYYDEEQSDAGIVFRDMFYDMKDRAFYLKDHQNHTDGVHVHQRLVGCELLNNEKTGPLHYWDAFGGQNMEEFIFDTEKHTIQVKMPWVITWDQLKRLH-ENFMYDNVYHPICIKTLRRYLNMEKKNVMRKVKPRVRLMQKKLSDSQGLQISCLATGFYPRHINLTLFRDAELVDDDQITGGEILPNGDGTYQMRKSLIVSEEELQKGHKYNCTANYLNLDNKMDIVFDVAESDPGSFSVSVVMGVLVFVGLS--------------------VLSITALIMRRKRRDTGSVSGTSQNQYVYAQTSVQDAT----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3AVG2-1", "uniprot_id": "A0A8M3AVG2_DANRE", "id": "A0A8M3AVG2-1", "name": "", "aln": "--MKTMLFLLYLLSCLTFTDAGFHSLLVLATYVDG--QTPFPELSVVVMLDDVQIIYYDSDT-WRVFHRSPSDSKYYDEDQSDADAVFHDTYDEMKYRVLHLKNQLNHTDGITVLQRIVGCELFN-DKPGIYHLWDAHDGKTIEKFTFNIYNHEFQLKNQWFRTWDQVMIQQ-KRIVHENIYYPVCIKVLRRYLNVEKNSVMRKVKPRVRLMKKKLPDSQGLQISCLATGFYPRHINLTLFRDAEPVDDDQIIGGEILPNGDGMYQMRKSLIVSKEELDEGHEYTCTMKHLNLDNKLDIVFDVSGTVPGCFSVSVVISVLVFMCVS--------------------VFIITKLIMRRKRQDTG--RGSEKCDYSPTISSSQDEI----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58J1X9-1", "uniprot_id": "A0AC58J1X9_DANRE", "id": "A0AC58J1X9-1", "name": "", "aln": "--MMYLVLAVCILSASVFSQSGSHSLWVFATFLTGDISVQFPEFSAVVMLDDIVIGHYNADD-RSFVPSTVQESVNIT-EQITISTVCKGIHEGMKTKAYYLIDYLNHTRGLHVQQRLVGCELLQ-NEPGQMMTLEAFNGESGFERRYDIQ-GDQQTHWKWPVIKSRAQLEY-DAWLYAHFYRPLCINQLRKYLKKEKKRVMARVKPRVRVIQRTCSKTGKIQMTCLATGFYPRHINLTLLQDGQPVNEERVMGGELLPNADGTYQMRKSVELSAEEQRERRTYTCTVNHLSLDNKLDISIEPG-LDPVIIFPSVLLLLCVFGVLAGFLMWRKKYKQPEQVHKHFHCFTDKLIFIRYKHCSLRFLIVFLPLQVTYTPTSATDQTTEQSQL----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58IU49-1", "uniprot_id": "A0AC58IU49_DANRE", "id": "A0AC58IU49-1", "name": "", "aln": "---MDKILLLFLFLLPTSAPKGSHSLCLLATYIKG--PSPFPELSGVMMLDDIPLLYYNGDT-KTFFMRGNTTAEDNVFDANAFLSIIGHIQSSFVDRWGLASRDLNKTDRIFTLQQLVLCELSEDGEHGKMISRDAVEGTTTDELQHVDHKFTYKHTLNVSAYLIDFYLEL-TKSLHKTLFQPTCFKTLSGYLIQRRNQINRKVKPKVRLFKKELS--SGFIVSCLATGFYPRHINLTLLRDGQPVSDHDVTGGDLLPNGDGTYQMRKSLEIRAEE-RQKHKYSCSVKHLSLDNKLHVDLDFDHGEPFKLLIPTVLVVLTICSTFIKERGRK-------------VCDEVDSYVRPGATWNGEWLQESCGAMTRVFMHVAKGAFLDKLYDVSF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . :.. . : *.:: :. . : : : . :: : . * * . * : : : ** . : . : * .:**:*: : : ::. : .: *::***.* : :: :: : : * :: .* .: : . : : . ", "identical_positions": 17, "similar_positions": 61, "identity": "4.31%" }, { "cls_id": "homologset.agr.HGNC:16370", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DBS9-1", "uniprot_id": "OSBL3_MOUSE", "id": "Q9DBS9-1", "name": "Oxysterol-binding protein-related protein 3", "aln": "---MSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMTYTQ-----EPPVQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQADIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEE---------LFDEWVSKLRHHRMYRQNEIAMFPRDVNHFFSGSSVTDSAPGVFESVSSR-KRSSLSKQNSFPPGSNLSFSCGGDTRVPFWLQSSEDMEKCSKDMAHCHAYLLEMSQLLESMDVLHRTYSAPAINAIQ----------------------------------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQEDLCHVAHKVYFALRSAFNSISVEREKLKQLMELDTSPSPSAQVVGLKHALSSALAQNTDLKERLRRIHAESLLLDPPAVPKPGDN----------------------LAEENSRDEGRALVHQLSNESRLSITDSLS---EFFDAQEVLLS-----------------------------------PSSSENEISDDDSYVSDISDNLSLDNLSNDLDNER------QTLGPVLESSGEARSKRRTSLPAPGPNT----------SSVSLWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAAFAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGASSSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFFRKSSDDAWVSNG---TYLELRKDLGFSKLDHPVLW", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6GM73-1", "uniprot_id": "A0A8I6GM73_RAT", "id": "A0A8I6GM73-1", "name": "Oxysterol-binding protein", "aln": "---MSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMTYTQ-----EPPAQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQTDIEREKLHGSIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSED---------VFDEWVSKLRHHRMYRQNEIAMFPRDVNHFFPGSSVTDSAPGVFESVSSR-KRSSLSKQNSFPAGSNLSFSCGGDTRVPFWLQSSEDMEKCSKDLAHCHTYLLEMSQLLESMDVLHRTYSAPAINAIQ----------------------------------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQEDLCHVAHKVYFALRSAFNSISMEREKLKQLMELDTSSSPSAQVVGLKHALSSALAQNTDLKERLRRIHAESLLLDPPAGPKPGDN----------------------LAEEISRDESRALVHQLSNESRLSITDSLS---EFFDAQEVLLS-----------------------------------PSSSENEISDDDSYVSDISDNLSLDNLSNDLDNER------QTLGPVLESSGEARSKRRTSLPAPGPNT----------SSVSVWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAHMPSPLERMVYVAAFAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLRDDSCHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGASSSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFFRKSSDDAWVSNG---TYLELRKDLGFSKLDHPVLW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H4L5-1", "uniprot_id": "OSBL3_HUMAN", "id": "Q9H4L5-1", "name": "Oxysterol-binding protein-related protein 3", "aln": "--MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQ-----EPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEE---------VFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSR-KRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKD---------------------AKGTLQVPKPFSG-PVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDN----------------------LAEENSRDENRALVHQLSNESRLSITDSLS---EFFDAQEVLLS-----------------------------------PSSSENEISDDDSYVSDISDNLSLDNLSNDLDNER------QTLGPVLDSGREAKSRRRTCLPAPCPSS----------SNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNG---TYLELRKDLGFSKLDHPVLW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R2E5-1", "uniprot_id": "F1R2E5_DANRE", "id": "F1R2E5-1", "name": "Oxysterol-binding protein", "aln": "--MSSEEKSSTMSQKISSPSHSNSSSSSKHDSRQDSWEIVEGLRGGHSNVQ-----EPEKQAGFMLKKRKWPMKGWHKRYFYLDKGILKYAKCAADVEKGKLHGCIDVGLSVMAIKKKAKCIDLDTEENIYHLKIKSQE---------LFDEWVSKLRHHRLYRQNEIAMFPHEKALFHPHYPLT-SSPTIPDSQAIR-KRASLAKQSSLH--SPAPFTS--QAKVTAWLQSSDDMDRCTKELSVCEAQLLELNHLLRSMEVLHRTYSAPAINALQASTYDSPKKEKRHPRKWRPKNYGKD---------------------NKTTLQVPSCISAGSVRLHASNPNLSSVDLTTEKTYHEPLDSPIDVSKLQEDFCRVANNLHTTMKSALCMLTTEKERVKQMLEHEPCPSPSAQLLGLKNALTAAVTQNAELRERLCKIHAESHISEPTVHINLSPGP---------------------LQKQDSSDCSRPLVHQASNESRASISESLS---EFFDAQEVLLS-----------------------------------ASSSENEASEDDSYISDISDNVSMDNFSNEAENER------LNTGCLVNGG--FQEQRRSCLPSPSPNT----------SNISLWNILKNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAHTQDPFERMVYIATFAVSGYASSYYRAGGKPFNPVLGETYECDRPDKGFRFVAEQVSHHPPISSCHAESKNFIFWQDVRWRNKFWGKSMEIVPVGSSHVVLPGFGDHYEWNKVTSCIHNILSGQRWIEHYGEISIKNSNSEKCQCKVTFIKAKYWNSSMNEVEGSVTDHKGKVVHKLFGKWHEGMYCGSPPSATCIWRTNPMPPEFEQYYGFTKFAMELNELDPLTKPLLPPTDTRLRPDQRLLEEGNVQSAEVQKQRIEQLQRERRKVLEENHMTHQPRFFQKSKDETWVSNN---TYWDLRKDPGFSNLDCPVLW", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38713-1", "uniprot_id": "OSH3_YEAST", "id": "P38713-1", "name": "Oxysterol-binding protein homolog 3", "aln": "METIDIQNRSFVVRWVKCGRGDVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDTKTLLDYTTKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQEIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFNASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDKIIIIDSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLNGTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRFVTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIVEETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAASPPSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYR-DKTRTLRKPFNPLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLAN--ETTHETIWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERR----NKGQDVEPKYFEKVSKNEWKYITGPKSYWERRKKHDWS--DISQLW", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 160, "similar_positions": 298, "identity": "15.92%" }, { "cls_id": "homologset.agr.HGNC:16371", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96L46-1", "uniprot_id": "CPNS2_HUMAN", "id": "Q96L46-1", "name": "Calpain small subunit 2", "aln": "MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTP-EPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9D7J7-1", "uniprot_id": "CPNS2_MOUSE", "id": "Q9D7J7-1", "name": "Calpain small subunit 2", "aln": "MFLAKAILEGADRGLGGALGGLLGGGGQARAGGG-NIGGILGGIVNFISEAAAAQYTP-EPPPQQQHFTVVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKELKTEGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVFKQYDSDHSGSLGSSQLHGAMQAAGFQLNEQLYLMIVRRYADEDGGMDFNNFISCLVRLDAMFRAFKALDRDRDGLIQVSIREWLQLTMYS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q1LYC9-1", "uniprot_id": "Q1LYC9_DANRE", "id": "Q1LYC9-1", "name": "", "aln": "MFLLK-----------KAIG----------------------GVIDVIGNIDPNQFVPSEPPPPRRPLAYAVSNESAEEQQFRKVFNQLAGDDMEVSPTELMNILNKIISKHGDLKTDGFTIESCRSMVAVMDSDSTGKLGFHEFKHLWNNIKKWQGIYKTYDRDHSGTIGADELPAAFRAAGFPLTDQLFQMIIRRYSDESGNMDFDNYIGCLVRLDAMCHAFKTLDKDNDGTIKVNVQEWLQLTMYS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** * *:* *:::.*.: . *:.* **** :: :: . :.** * ::**: *.**** ****..*:*******::*** :***:**::::***:*:*****:******.***:********* ::* ** ****::*:.:* .*::**** *.:**: **:***::*.*.***:*:*.******** :***:**:*.** *:*.::*********", "identical_positions": 127, "similar_positions": 66, "identity": "51.0%" }, { "cls_id": "homologset.agr.HGNC:16372", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ACR7-1", "uniprot_id": "D4ACR7_RAT", "id": "D4ACR7-1", "name": "", "aln": "MAEGPEEARSRPPGQDGGSEDHEPVPSGPGSPSSSS-------AAAPRPPALTTV-----ASAVPEPEPQCELRKRRE----TGAEPQEPGGCEASDG------PGRLSAREYSRQVHEWLWQSYCGYLTWHSGLAALPAYCGPPP---AAPQPAAPPP---PPPPPQLAYYNPFYFLSAAAPGPGAATSAG-ATPTAVAGLTARAPHVQASARAVPVTRVGSAAPARTASDTGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSGIKDISKFAMHYIIEEIDEDTSMEDLQKMMIVALIYRLLVCFYEIICIWGAGGATPGKFLLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNG-VR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UBU6-1", "uniprot_id": "FA8A1_HUMAN", "id": "Q9UBU6-1", "name": "Protein FAM8A1", "aln": "MAEGPEEARGHPPGQDDGGGDHEPVPSLRGPPTTAVPCPRDDPQAEPQAPGRPTAPGLAAAAAADKLEPPRELRKRGEAASGSGAELQEQAGCEAPEAAAPRERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAYCSPQPSPQSFPSGGAAVPQAAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAPVAGLGPRAPHVQASVRATPVTRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSGIKDISKFAMHYIIEEIDEDTSMEDLQKMMVVALIYRLLVCFYEIICIWGAGGATPGKFLLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNG-VR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RP26-1", "uniprot_id": "A0A8M1RP26_DANRE", "id": "A0A8M1RP26-1", "name": "", "aln": "---------------------------------------------------------------MAKKNSAKEADKNGE-----GANDDD-----------------KMTTNEYCARLQQWMWRYYSGYVSWQSWVLMSAPLF----------------------PPPQFG-----------CQAPGSSASVYPTTPADIAAWYN---QMSSPGAIRPADTATSSTGDRGAAQP---AGREYIIPSPLRRFLAETVDFFILFCVKATIVLWIMHLCGMKDISKFIMQFIVEEIDENTSLEDLQKMMVVALAYRVLVCVYEIICIWGAGGATPGKFLLGLRVVSCDTTVLVQPNRVLVVPASTVSLSASTVRALNKNFSIAFLFPIFITLLFFQHNRTVYDVVAGTIVVQRRSRAR", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. * *. * **: :: ::::.**. ::::*:*: *.**::*:* : .. ****:. . .*.. ::. :**: :*. ::.:. *. . *:: * .::. *****:*** :**:** ******* :****** ****.*:****** *::*:*****:**:*******:*** **:***.************************:***:**: *.****:*:*.**:::**:*** ****** :** ************.**:*******:*.. .*", "identical_positions": 159, "similar_positions": 84, "identity": "38.41%" }, { "cls_id": "homologset.agr.HGNC:16378", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A6R6-1", "uniprot_id": "D4A6R6_RAT", "id": "D4A6R6-1", "name": "", "aln": "-------------RMSQEPRMYSLLLVLFLSHGGACQREPSSRQDLHPLLQKMAEEIIEGSYLNALLDLALFESSHVWTADLSHRVLAYLNSRNVAFTIPSLQAVMETHLEQYLYQ--PQKLLEDLRATDAQQFHT----AMKCLLEDKWGHLDLEDIVINLGDIRDEALQSPGVNRSLFLITLER-----------------------CFQVLNALECVEVLGKVLRGSSGSFLQPDITDRLPQDLHEDAFKNLSAVFKDLYDQTSAHTQRALYSWMTGILRTPFNVTDGSISWVSAEKLWILGRYMVHLSFEEIMNISPIEIGLFISYDNATKQLDMVYDVTPELAQAFLERIRGSSFDMRNIST-IHR--------------LGLLVCFYDGLELLDAALAQVLLHQMLKCSRLRGFQAGVQKLKANLLD--IATENQTLNETLGSLSDAVVGLTSTQLESLSSDAVHSAISTLNQVTGWGRSQIVILSAKYLAQEKVLSFYSVSQMGVLLAGVGTQAFYSMDHKDLWQVLRSPLSQDMSDLSPVQHQGVLSKLMEAEDAASGIVEVPRALFKEVSLYDLWKGPGFNATVLKEKELRRSQALFLYELLEKTTERPEELLSSRQLVKGVQCSHIDAMSAHVFLALFQHFENNFSLLSPDQVNCLAWKYWEVSRSS---------------MPPFLLATLPSRFLASVPPSRCVRFLISLGKRHLDTLVLDSDKRSLVIRKVQQCLDGVIADEYTVDIVGN--LLCHLPASFIERGISPRAWATALHGLRSCRALSSGQKAAVRFRLLEQWGPPQNWTAETTKDLAPFLAFFSGDELHTVATKFPEILQQTASKMVG---TLLPKEF-LWAVFESVRNSSNESPGSDPTFGCHG------VVTPSSDDIVKLAEANACWDPEVLLCMEEDTFIRNVELLGAVKGFSRPQLMALKEKAIQVWDLPSHWKEHHVVSLGRIALALNESELEQLDLSSIDTVASLGQQTEWTPGQAKSILQEFLEDSGCGIQDLKSFHLVGLGPTLCAMDPTEIPLIKTSEFRAVVARIGTLLCSTPVLAGFKKKAEVVFGRPTEWTSSILQELGTIAAGLTKAELRMLDKELMPYFQPWAIRCLPGEVFKELSTEQIASLGPQNAAFVTHSQRLQLSSSQLQSLQRAVDGAKTHFWQIDPMSSSPTWPASTGSPTGEPTFQALWLGCPLLLLMAKS---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K561-1", "uniprot_id": "OTOAN_MOUSE", "id": "Q8K561-1", "name": "Otoancorin", "aln": "--------------MSQGPRTCSLLLVLLLSHGGAYQREPSPRQDLHPLLQKMAEEIIEGSYLNALLDLTLFERSHVWTADLSHRVLAYLNSKNVAFTIPSLQAVMEAHLEQYLYQ--PQKLLEDLRATDNQQFHT----AMKCLLEDKWGHLDLEDVVINLGDIRDEALQSPGVNRSLFLITLER-----------------------CFQVLNALECVEVLGRVLRGSSGSFLQPDITERLPQDLHEDAFKNLSAVFKDLYDQTSAHTQRALYSWMTGILRTPFNVTDGSVSWVSAEKLWILGRYMVHLSFEEIMNISPIEIGLFISYDNATKQLDMVYDITPELAQAFLERIRCSSFDVRNIST-IHR--------------LGLLVCFYDGLELLDATLAQVLLHQMLKCSRLRGFQAGVQKLKANLLD--IATENQTLNETLGSLSDAVVGLTSSQLESLSSDAVHSAISTLNQVTGWGRSQIVILSAKYLAQEKVLSFYNVCQMGVLLAGVGTQAFYSMDHKDLWQVLRSPLSQDMSDLSPVQQQGVLGKLMEAEDATSGIAEVPRALFKEVSLYDLWKESRFNATVLKAKELRRSQALFLYEFLGKTTERPEELLSAGQLVKGVPCSHIDAMSDHLFLALFQYFDNNFSLLSPDQVNCLAWKYWEVSRSS---------------MPPFLLATLPSRFLSSIPPSRCVRFLISLGKRRLETLVLDSDKRSVVVRKVQQCLDGVIADEYTVDIVGH--LLCHLPASFIERGISPRAWAAALHGLRSCTALSSEQKAAVRVRLLEQWGPPENWTAETTKDLAPFLAFFSGDELHTVATKFPEILQQTASKMVG---VLLPKEF-LWAVFESVQNSSNESPSFDPTFGCHG------VVTPSSDDIFKLAEANACWDPEVLLCMEEDTFIRNVELLGAVKGFSRAQLMALKEKAIQVWDLPSRWKEHHIVSLGRIALALSESELEQLDLSSIDTVASLGQQTEWTPGQAKSILQAFLEDSGYGIQDLKSFHLVGFGPTLCAMDPTEIQLIKTSEFRAVVARIGTLFCSTPVLAGFKKKAEVVFGRPTEWTSSILQELGTIAAGITKAELRMLNKELMTYFQPSAIRCLPGEVFKELSTEQIASLGPQNAASVTHSQRLQLSSAQLQSLQRALDGAKTHSWQTDPLSSSPTWPASTGSPTGEPASQALWLGCTLLLLTAKS---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7RTW8-1", "uniprot_id": "OTOAN_HUMAN", "id": "Q7RTW8-1", "name": "Otoancorin", "aln": "--------------MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQSSHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQ--PQKLLEDLRKTDAQQFRT----AMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLER-----------------------CFQMLNSLECVEILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDITPELAQAFLERISSSNFNMRNTST-IHRQAHELWALEPFPKMLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLRGFQAGVQKLKAELLD--IAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSPYQVNCLAWKYWEVSRLS---------------MPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGN--LLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMAR---TLPTKEF-LWAVFQSVRNSSDKIPSYDPMPGCHG------VVAPSSDDIFKLAEANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7EXK7-1", "uniprot_id": "E7EXK7_DANRE", "id": "E7EXK7-1", "name": "", "aln": "MGFYREVFILSLLVQLAAVMSQDMVASQMLNSNQSTIGFPRLPADFREMAKKLMITCSNKGYQMPAMNHTQNSSHAQMMESPVPVFLELLSSIPPFSHARPYMKPNDTAEEQEITRNFAEKMRNCTNMGHMIEFMRNATEGPRCFMRAFVAPLSWTIIMQNGTDLLKEDLTKLLWAAKPFLETMPPSSFVLPPFTQNSQLAEMMKVFSEVFAVLSEQQKNEIIGWVKERNAQNEFNCHLKAPTTNNSQQEKPASQSDPSVKMLDMMSKPSDEVAKPSVMNVSTPVHTVCPAKMLWLKAKMLSMMGPFLSSLPIEEVKNIPKEELCDFFRTPDFPPSFQNVTGMKPVLGRTLFQRLKQECSSSDNFTQNVYR--------------LGSLACFFDSAPSLNLTLSRKLLSQIEACSNQE-----VDKVKRQLVQNILEKDDSSSSELLQSLGSSVSALPVSRLSRFSPEDLNSTLSTLSQVK-WSPAQATALAKKMLETAKNVSGEKLLSLGSVVRGVASSLLKNVKTEGLLENK--ALENMAEKMSSLQRTALLNAFRRDVNASELVKGLPDSLLSSLSLSILEKADLGSVDQLKGRGWTRAQSVFLLKKIMGNKINLGELGKLGQAVQGVTCEMLEKFNRTDALQMSQELNKSYIWLSRTQIRCAAQKLFASLEAQRAGYFNDIKNAELQAIPAVLLINLPVEKIQNLSDAVCPAFMEKMKDVNLSSLPNSSPARSALTKRAIGCLKGNLSDLTAAEVLTLGPLVCELDPVWISS-LNPAARNATLKSLASCQYIQQQNRQDLFRLLNAIYGDPAYWSEEDVRAIGPLLFLNDTAVEKLPSKSWLKLYLSELDSLSSQPAVPPPKEFSTWFDLSALRRKLFELKTTSALLSRRKRAVVLTTTDLTLANIEDLKQGNVYWTAAQFSKMAVQIFKDAMPTLGEINNYSTEQLTALKAKTVEAWGSVSMLNESLISNLGCICQSFSAEELGNLSIASLDTLEILAN-CNFTQTQRAAIWQAFQRTTGMNVFGLGELETAGLGQFICGLQPAQIDLLNPLSFREAVEAVGRTSCPPNILDRLKEKTVAVFGKPENWTEAQICIMGNIIAGLNAVEMSRLNPTILPFIQPSAIPLIPGDRLAMLSVSQLKALGPDNAAMVTDAQRVGLKVDQRAALDEAVG-LKTARADVPTGTSTGNSTGNSNPSSGGSGAQPLKGGATVESMAGSVLLVQVIVLVLIGYIF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:. :*. . : * *:: : ::: : .* . :: . . .* *.* . : ** : : .:*: : . . :* . :*::. *. :: : :: .. * . . ** *: * :*. : *::* * . .: . :: .:. ..: ::: . * .: * * ::.. . : .: . .. . *:.*: * ::* :: *.:**: :*. *: *: : . .:: * .:.* *.:::::*: . . * : ::* ** *.**::. *: :::: ** *: **. . *:*:* :*:: : ::.: .* * **..:* .*. ::*. :*.: ::.::***.**. *. :* *: * * * :* .: .:* :: **.:. : .:. :.: : .:.: ..:*. *: .:*. : . ::: : : :::..:** * : . ** : *:*::** : : .. . ** . * *:** *. :: :. * * :::.: ** *:.* * * : . . :*..** ** . : .:. : * *: .: . *.:* .* :: : ::. **.. ::* :.::: *:*.* . *. :.* * ::*:.* .* :. :: : * :* * *: * .: :.*:* : . :..: :: . ..: . .*** * :.:::.. : .. . : .. : :* .* :.*. * : * : * : ** ::.:* ** :** *:::.*. * .* : .** *. ::. .** :*.::*:**: *. ::* * :* * : :* .: .* .:. .*:* :*.:: ::* *:: .** .* :* *.. :* :*.*: .*** * :**.: : :*.* **:. .*: *: ::.::** ** :*.: : **..*: :***:*** **.:** *. * :*:.*:. ** : . :: . ...: ..:* * *..: : .. ", "identical_positions": 224, "similar_positions": 431, "identity": "18.08%" }, { "cls_id": "homologset.agr.HGNC:16379", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AC58GIM4-1", "uniprot_id": "A0AC58GIM4_DANRE", "id": "A0AC58GIM4-1", "name": "", "aln": "MRRHVQTSLTKSDVMRETPANFQQDQNPETPPILSPSQQESQSRRARRTEQSMSSSLPAQNKMDKQKLRPEIPPRVSKSSAQRLSRDLTCSICLDLFKQPVSLPCDHTFCEACITSYWSGPRVKCQAGSGSCPQCRKVFHGKSYRPNRIVANIVESYCQGMEESGVRLGAVSEPAPTAPLCMRHREELKLYCEEDQELVCLVCGISQDHRAHTLVCVQDAQKRYRASLTTSANALQKELNTALECERETEEEVKKLKDHTADLKQRIEAQFSELHQFLYQEEKLLQVKLKTEERRELIRLDEHKALLSVEISRLRRAVNDIEDKLSEQDPYTLLRSIKGLLQRQPPKFERPTLTPPSLCEGRFAGPLQ--YRVWKSLKGSIYPVPSAITFNSKTANPWLSLTSSLTCVRYQTFNSSVQDNPQRFNAALSLMGGQGFTKGRHYWEVEVYSSTVWTVGVARESVTRKGVINT-----------------MPANGFWTLSLSYGVQYMAG----TSPPTLLS--LEEPLARIGVYLDYKRGLVSFYNAESM-THLYTFR-DTFTETLFPYFNLGFLDKVHENEPLKVFMPKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IYM9-1", "uniprot_id": "TRI22_HUMAN", "id": "Q8IYM9-1", "name": "E3 ubiquitin-protein ligase TRIM22", "aln": "---------------------------------------------------------------------------MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKES-VIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSP--------QEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQY-YWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDF-SAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNP-----WNCLVPMTVCPPSS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. * :.:::**.***:*:.:*:** *.*:**:****: . . * . *..*** *:. *: . **** :***** : .. : . . :* :* ::*:::*:** :::* ** :**:*:.* . :::. *. : .* .: : * ** : * : * : .:* . *:: :*:* *.*:: :* :**: **: * . * .* . * : . :.*:: :* .. * *. : : :. .:::*. .. .* . . *. :* *.*.. * : :*. :*.. :::: . *: : :.** * :*:.::* * *:.*::****:* .. .* :** : : : .: * *:*.:.*. :* * :* *.:*: : * .****:***: *:***:*. . : :*.* *:.. :**** : *:.* *. ", "identical_positions": 131, "similar_positions": 171, "identity": "22.24%" }, { "cls_id": "homologset.agr.HGNC:16380", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q66H79-1", "uniprot_id": "Q66H79_RAT", "id": "Q66H79-1", "name": "E3 ubiquitin-protein ligase TRIM32", "aln": "MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRACGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELTGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRVQEELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETAD---EEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAVEEGAASSASASVTFREMDMSP---EEVVPSPRASPAKQRS----SEAASSIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CH72-1", "uniprot_id": "TRI32_MOUSE", "id": "Q8CH72-1", "name": "E3 ubiquitin-protein ligase TRIM32", "aln": "MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRGCGRRLPRQFCRSCGVVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELTGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRIQEELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETAD---EEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAGEEGAASSASASVTFREMDMSP---EEVAPSPRASPAKQRS----SEAASGIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTMDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13049-1", "uniprot_id": "TRI32_HUMAN", "id": "Q13049-1", "name": "E3 ubiquitin-protein ligase TRIM32", "aln": "-MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETAD---EEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEA-TASAASTSVTFREMDMSP---EEVVASPRASPAKQRG----PEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B7G1-1", "uniprot_id": "A0ACD6B7G1_DANRE", "id": "A0ACD6B7G1-1", "name": "RING-type E3 ubiquitin transferase", "aln": "---MATSTSLDPELVREVLECPICLETYNQDQLRPKLLQCGHSVCRQCLEKLLASTINGVRCPFCSKVSRMSSISQLADNLTVLKIIDCASACSSNMGLMCKSCKNRLPRQYCCDCSIVLCDICKNEGHQRQGHVVQAIRMAAELRRKDIGAKLSDLREAMGNIQKKKAAIDNVTKSLRMKYKAVQQEYAKAELRLQEELGRSRRAFATSLAEIEKLNAQLLEEQTYLLNIAEVQVVSRCDYLTMRIKQTDIALLEEGSNNDEEEDLDLKTNLPVVLKLQDPELVKIENSKSLEVGQLTTKPCNVNVEEEEDGLDFPTATSAPLDIYRDIDMVPAVEEAVCASPGSFKSKSVDGGGPSPGASGGQLCQFVKKMGCKGNLPGMFNLPVSICVTLQGEVLVADRGNYRIQIFNRKGFQREIRRNPSSIDNFVLSFLGADLPNLIPLSIAITAQGLIGVTDNYDNSVKVYTTDGHCIACHKNQLIKPWGIAAMPSGQFVVSDVEGGKLWCLAVDRNVGVVNYNRLCSAVRPKFVTCDSSGTVYFTQGLGLNIENRHNEHHLEGGFSIGSVGMDGQLGKQLSHFFSETEDFRCITGMCVDSNGDLIVTDSGRKEILQFPKEGGYNILIQEGLTCPVGVAVTQKGQLLVLDCWDHCVKVYTYLQRRRSSTC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::: *: : :*********:*::.::*******:***::***********:***********::*::*::**:********** *. ..: ***:.* .*****:* .*.:***: *:: .** ** . .:: *** **:*:* **: *** *::*::***::.*::.*: :**** ***.: * *:*:**.***: *: ****:** *:*::***:*********.******: :***:*:***** :: **: :*.:.** *.*** **:*: : .*::** ..** .**:*:. .:::::. :*::** * * * .** : :*. . . .**. * * *:****.**. *********: ** *.*************:*.**** :****.**.**.************* ***:*:..:*******.****:**** ****:***:.** *****:*:*******:*********::***. ***:*. *************:.************:***:*************** *****:*:******.******:*****:.*****:**.*****:*** ***.:**:********:*:* *************:*:*:* ** *:. ", "identical_positions": 411, "similar_positions": 164, "identity": "61.71%" }, { "cls_id": "homologset.agr.HGNC:16381", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M317-1", "uniprot_id": "A0ABK0M317_RAT", "id": "A0ABK0M317-1", "name": "Protein phosphatase 1L", "aln": "--------------------------MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKSHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLP----------------------------EALKQHLQDYEKDK-------------------------------------------------------------------------------------ENSVLTYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN----------SSKTEEQ-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BHN0-1", "uniprot_id": "PPM1L_MOUSE", "id": "Q8BHN0-1", "name": "Protein phosphatase 1L", "aln": "--------------------------MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKSHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLP----------------------------EALKQHLQDYEKDK-------------------------------------------------------------------------------------ENSVLTYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN----------SSKTEEH-----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5SGD2-1", "uniprot_id": "PPM1L_HUMAN", "id": "Q5SGD2-1", "name": "Protein phosphatase 1L", "aln": "--------------------------MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLP----------------------------EALKQHLQDYEKDK-------------------------------------------------------------------------------------ENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRN----------SSKTEEQ-----------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QD96-1", "uniprot_id": "F1QD96_DANRE", "id": "F1QD96-1", "name": "Protein phosphatase 1L", "aln": "-------------------------------MSPLALLARTLRCVLLRPGGLLLLGFSLALWSFIFHTGELQGLLQMLR-GRAAGPGLPVPLLPRD-----GPPEEQLSNTWQLRSGAAAVYSIQGRRDHMEDRFDILTDTRNRSHPAIFSIYDGHGGEAAAEYAKAHLP----------------------------IMLRQQLQRYERQK-------------------------------------------------------------------------------------ENSAVSRQAILRQQILNMDREILEKLTASYDEAGTTCLVALLSEKELTVANVGDSRAVLCDKDGNAIPLSHDHKPYQLKERKRIKKAGGFISFSGSWRVQGVLSMSRSLGDFPLKKLKVLIPDPDLMTFDLDTLQPQFMILASDGLWDTFSNEEAVHFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFKK----------RAGNKD------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9XZ28-1", "uniprot_id": "Q9XZ28_DROME", "id": "Q9XZ28-1", "name": "PPM-type phosphatase domain-containing protein", "aln": "MDDELEDKVFYQTYVSHMKILSKFAVGFSSINSPLAYIWKLCRLYVLRP-EVIFCGLILFVLLLYLQAVDVWSRSILGRIQATLGRQKAVKMMELS-------ASAGDHQSWEEMKQQSSAFAVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLKTEGNSGDYDKSPYLARKQSRKDANKENTEPTAGVMRKDSLRKAHSTTADCSAIKQKTTEASIADIYTVQLNSAMRASGNLGAAKDSFLNNNNNGQNGAANAPPPNYEAKCYIEHGRINFGKLITDEIMSADYKLVEQAKRATNIAGTTALIAIVQGSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGVWRVAGVLATSRALGDYPLKDKNLVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTFALEHLKEPDFGAKSLAMESYKRGSVDNITVLVIVFKNDVYKIGSSAGKAGEESLKVPAKSQPVAPAVVQRSNSIKTK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *: : : * :*** ::: : * : ::: :: * . :: . . ::*: . :.::: *** :***** : : *.: ::*.::****** **::.* * :* : :::: *:. :. :: ::*:. * :::*: . : : ****.*:*::. ..* ********.*: * * *****.**** *::*****: *****:* * *** *:*: **:***:***. :::*. **::**:*: :*.*:*********:****** * *:*.**.*****:.::*: **. *****:*: *:: : :. ", "identical_positions": 129, "similar_positions": 112, "identity": "24.25%" }, { "cls_id": "homologset.agr.HGNC:16384", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08629-1", "uniprot_id": "TIF1B_RAT", "id": "O08629-1", "name": "Transcription intermediary factor 1-beta", "aln": "-------------MAASAAAATAAASAATAASAASGSPGSGEGSAGGEKR---PAASSAAAASASASSPAGGGGEAQELLEHCGVCRERLRPERDPRLLPCLHSACSACLG-------PATPAAANNSGDGGSAGDGAMVDCPVCKQQCYSKDIVENYFMRDSGSKASSDSQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKTR------DGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKNTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLN---AWTKSAEAFGKIVAER---PGTNSTG--PGPMAPPRAP-----GPLSKQGSGSSQPMEVQEG-----YGFGT-DDPYSSAEPHVSG---MKRSRSGEGEVSGLMRKVPRVSLERLDLDLTSDS--------------------QPPVFKVFPG------------------------------------------------------STTEDYNLIVIERGAAAAAAGQAGTVPPG-----APGAP--------PLPGMAIVK---------------------------------------------------------------------------EEETEAAIGAPPAAPEGPETKPVLMALTEGPGAEGPRLASPSGSTSSGLEVVAP--------------------------------------------EVTSAPVSGPGILDDSATI--------------CRVCQKPGDLVMCNQCEFCFHLDCHLPSLQDVP--GEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRP--LHQLATDSTFSMEQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFK-QFNKLTEDKADVQSIIGLQRFFETRMN---------------DAFGDTKFSAVLVEPPPLNLPSAGLSSQELSG-PGDGP---------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q62318-1", "uniprot_id": "TIF1B_MOUSE", "id": "Q62318-1", "name": "Transcription intermediary factor 1-beta", "aln": "--------------MAASAAATAAASAATAASAASGSPGSGEGSAGGEKR---PAASSAAAASAAASSPAGGGGEAQELLEHCGVCRERLRPERDPRLLPCLHSACSACLG-------PATPAAANNSGDGGSAGDGAMVDCPVCKQQCYSKDIVENYFMRDSGSKASSDSQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKTR------DGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKNTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLN---AWTKSAEAFGKIVAER---PGTNSTG--PGPMAPPRAP-----GPLSKQGSGSSQPMEVQEG-----YGFGS-DDPYSSAEPHVSG---MKRSRSGEGEVSGLLRKVPRVSLERLDLDLTSDS--------------------QPPVFKVFPG------------------------------------------------------STTEDYNLIVIERGAAAAAAGQAGTVPPG-----APGAP--------PLPGMAIVK---------------------------------------------------------------------------EEETEAAIGAPPAAPEGPETKPVLMPLTEGPGAEGPRLASPSGSTSSGLEVVAP--------------------------------------------EVTSAPVSGPGILDDSATI--------------CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVP--GEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRP--LHQLATDSTFSMEQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFK-QFNKLTEDKADVQSIIGLQRFFETRMN---------------DAFGDTKFSAVLVEPPPLNLPSAGLSSQELSG-PGDGP---------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13263-1", "uniprot_id": "TIF1B_HUMAN", "id": "Q13263-1", "name": "Transcription intermediary factor 1-beta", "aln": "------------------MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLG-------PAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSR------DGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLN---AWTKSAEAFGKIVAER---PGTNSTG--PAPMAPPRAP-----GPLSKQGSGSSQPMEVQEG-----YGFGSGDDPYSSAEPHVSG---VKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADS--------------------QPPVFKVFPG------------------------------------------------------STTEDYNLIVIERGAAAAATGQPGTAPAG-----TPGAP--------PLAGMAIVK---------------------------------------------------------------------------EEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAP--------------------------------------------EGTSAPGGGPGTLDDSATI--------------CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVP--GEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRP--LHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFK-QFNKLTEDKADVQSIIGLQRFFETRMN---------------EAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP---------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4KGE5-1", "uniprot_id": "A0A0B4KGE5_DROME", "id": "A0A0B4KGE5-1", "name": "", "aln": "MDMDLEQLKNDFLPLIAGIKQEQLDAVPTDALPQMSTPNTASGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSELDRSLPPLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGTPQPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHPQNMDISLRGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAMQNSLGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEGSEKSSSGE-------LSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNTSNSPALLGVNATGSPSPIENGRKSCGSASLGDSDGACLPAKRARRSAHEXNELMPGGKGTDGEQQAETGQERRQEEQQQLPAFLEEMDLEMPQRPHSLGSSVIQESADYVLQLLHAYAAAFGL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: * . .:*....*:. .. . : : .. ** * :.....* * :* * : * .: *:** *** **: *:. : *. : . ..:: : :** . :** : * :. : . .:. ..: *. *:**.*.* ***:**:*** :*::**:****:* *****::... *:.. . :: *::* :* * ****:**.********. *:**:*:* .: . :.*: *::**..:. *: *.. ** : . : : * :* : ::. ::* : :*.**: *: ::* :.: : * .:: *: :..: :* : * . ***...: *:* *** : :*:: .* :*. :::* :** * . :* *:.: * * *.. * * *** * .* : * .. * :. . :* . **.* : . :.** .*:*. . : :* *.::* . .:.* .* .. .* * .:*: :. . ****:. .*:. * :*** *: .:: :: ::.* .::*. :. :* . . * .. . ** :: *. **:. :. :* : **. .. *.:: : * ** . *:*: *::* ** :**:*::..:* .*.*.* ** : :*.: :** . ...: **. : * :*: * *:*: . :. .* : ...:.* :**:**: . . *.. *..** :*. : **. .. *:.*** :: :: ... : .* . .* : .. *. . * .**. ", "identical_positions": 216, "similar_positions": 314, "identity": "17.79%" }, { "cls_id": "homologset.agr.HGNC:16385", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V660-1", "uniprot_id": "G3V660_RAT", "id": "G3V660-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-----------MGLYATAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLR------PHLAKVLVYELLLGK--GFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQE--RPGQAHQVPRFVRVNTLKTCPEDAIDYFKRQGFSYQGR------ASSLEDLRTLKGQHFLLDPLLPELLVFPAQTD--LHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLK------NQGKIFAFDQDAKRLAAMATLLARAGVSCCEVAEKDFLTVSPSDQRYGQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKE-----------------------RLQALAGFQQRALCHAL-RFPSLQRLVYSTCSLCQEENEDVVQEALQ---QNSGTFRLAP---VLPTWPHRG-------------LSTFPGS-EHCLRASPETTLTGGFFIAVFER------AEVVPSPAPQTSAVVP----------------------EPLSKAPKRKRRR------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4F6-1", "uniprot_id": "NSUN5_MOUSE", "id": "Q8K4F6-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-----------MGLYAAAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLR------PHLAKVLVYELLLGK--GFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQESSRPGQAYQVPRFVRVNTLKTRPEDAIDYFKRQGFSYQGR------ASSLEDLRALKGQHFLLDPLLPELLVFPAQTD--LHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLK------NQGKIFAFDQDAKRLAAMATLVARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKE-----------------------RLQALAGFQQRALCHAL-RFPSLQRLVYSTCSLCQEENEDVVQEALQ---HNSGTFRLAP---VLPTWPHRG-------------LSTFPGS-EHCLRASPETTLTGGFFIAVFER------AEVVPTPAPQTDAMDP----------------------EPLSQVPKRKRRRKAAVGASMQPST", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96P11-1", "uniprot_id": "NSUN5_HUMAN", "id": "Q96P11-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-----------MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLR------PHLAKVLVYELLLGK--GFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGR------ASSLDDLRALKGKHFLLDPLMPELLVFPAQTD--LHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNKTSHLAALLK------NQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQLEEPGAGTPSPV-----------------------RLHALAGFQQRALCHAL-TFPSLQRLVYSTCSLCQEENEDVVRDALQ---QNPGAFRLAP---ALPAWPHRG-------------LSTFPGA-EHCLRASPETTLSSGFFVAVIER------VEVPR----------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3BD27-1", "uniprot_id": "A0A8M3BD27_DANRE", "id": "A0A8M3BD27-1", "name": "", "aln": "-----------MALYLKAAEILEKVEQKRGAVKTLVYDSKFPNIKQLFALVCETQKYSSVLQEIINSTKLLK-ETKLR------IHLAKVLVYDLLIGH--GVKCGG-AWKTTMLKHRARLQAALARIKIKRKVSRNQDLLPSSIQQTQNDVIPRYVRVNTLKTSLEDVIDYLKREGFSYQGT------PGRLEDLDRLSGKMFLCDLHLKDLLVFSGKTD--FHDHFLYKAGHIILQGKASCLPAFLLNPPVGSHVIDACAAPGNKTSHLAAIMK------NKGKLFAFDLDAKRLSTMSTLLLRAGVTCHKLANQDFLKVDPQNSEYKEVKYILLDPSCSGSGMVCLRDELP--ETQEDG-----------------------RLQALAAFQLHCLNHAL-QFPQLERIVYSTCSIHSQENEEVVTACLQ---RNPG-FRLVH---LLPDWPERG-------------HEPLT----QCLRASTAKTRTHGFFVAMLERRPAQSDKETPPLNTPLSSASQEKQDKPQSNPSDEEQENMETSNEQPANPSSKKKRKRNRKKHKKQES--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VDZ4-1", "uniprot_id": "NSUN5_DROME", "id": "Q9VDZ4-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-MSKKPHSIKVPTQYRATAKILKAALEQQKCIKTLIFAEKHARTRSLHTVLKKFSENRVALEKAIEETGLLRDNPSFD------PSLAKILVTELLFGR--KELNGESKPVQTVRSYKDRLLNSIRDFGVQRKEPN-----------------PRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFMTDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQ------NKGCIYSVEQDHVRYNTLCEITKDAGCDIVKPILGDALNLTP--ERFPDVEYILVDPSCSGSGMQNRMTVCD--EPKEDK-----------------------RLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQ---LNPSFKLLSCKKALRNKWHNVG-------------DKDYPNIGKNVLYCQPDSDLTDGIFLALFEK---------------------------------------------------RREGEKD-----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53972-1", "uniprot_id": "RCM1_YEAST", "id": "P53972-1", "name": "25S rRNA (cytosine(2278)-C(5))-methyltransferase", "aln": "MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLS-EDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTL--------KVDKWSELVPGSIYYDEFIPNLFGIHPSDK--ITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAM-SFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD--------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* : :* . . : :.::: . . *: : .: :*. . :* :**:.: * : .: * : : :: . *::*:*. : . . : * : * : :: : . . * * : ::*:*.:*:*:.* :* * . *:* *:*** ** : . : *: :::.: * * : : ** . : . .: :* :::********: ** * .:* : : **: ** :::.*.***: :*** ** * . : * . * : . . . *:* . :*: ", "identical_positions": 68, "similar_positions": 105, "identity": "11.93%" }, { "cls_id": "homologset.agr.HGNC:16386", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LRE5-1", "uniprot_id": "F1LRE5_RAT", "id": "F1LRE5-1", "name": "Oxysterol-binding protein", "aln": "MAS-------------------IVEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDS--------GFVPS-------------VQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKDDEQRKKVETLKDTTNSMVESIKHCIVLLQIAKDQSNAEQHADGVLSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPAQLCKS---EQRPSSLPVGPVLATLGHHQTPTPNSTGSGNSPPSSSLTPP-SHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSMSNGTSDADLFDSHDDRDEDGEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPRDRMVQVVKWYLSAFHAGRRGSVAKKPYNPILGEIFQCHWTLPNDTEENAELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLEYGEHYILTFPNGYGRSILTVPWVELGGECSINCSKTGYSANIVFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGIMYAKYATG-ENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGTVKH----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A8Z1-1", "uniprot_id": "OSBL9_MOUSE", "id": "A2A8Z1-1", "name": "Oxysterol-binding protein-related protein 9", "aln": "MAS-------------------IVEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDS--------GFIPS-------------VQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKDDEQRKKVETLKDTTNSMVESIKHCIVLLQIAKDQSNAEQHADGIISTINPVDAIYQPSPLEPVISTMPSQTALPPEPAQLCKS---EQRPSSLPVGPVLATLGHHQTPTPNSTGSGNSPPSSSLTPP-SHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSMSNGTSDADLFDSHDDRDDDGEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPRDRMVQVVKWYLSAFHAGRRGSVAKKPYNPILGEIFQCHWTLPNDTEENAELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLEYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIVFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGIMYAKYATG-ENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAVKH----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96SU4-1", "uniprot_id": "OSBL9_HUMAN", "id": "Q96SU4-1", "name": "Oxysterol-binding protein-related protein 9", "aln": "MAS-------------------IMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDS--------GFVPS-------------VQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKS---EQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSP-SHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATG-ENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z814-1", "uniprot_id": "A1Z814_DROME", "id": "A1Z814-1", "name": "Oxysterol-binding protein", "aln": "MASTTGSAPSLGPPQSGSGGSGTLEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDALIGIDDQEDNTFTITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRRPNHLELVARRVSEADAYLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKHSIVSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDDEEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEKAPDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYEEEEETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIP-GISQDAQEVRDGPVPWCRRDQLTFLAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVTFPNGYGRSILTVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKRNRVSAEVYAPSEKKPFVSITGEWSGLMEAKWHDKNKTEVFVDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFKPVGDNWIYAKPLSQRMYLQEKEAKR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** :**.**************:**** **************::* *******:.*:*****::*.*******:********. :***:*:: **:** **: : : ** *: . :: . ::::*******::*** :*:*.:: : .: ::.* ::*::.:*:*:: ***.** *****: ::. : . .: ...: . .: . .. .. :* * : *. ::. .* . ... *.** ..*. *:..*.. .: * : :. ** . .::.: . :: :.:.* : ** .. :: ..* . . . .* * ..: * .: . .::: *:* * *:* ******::*************************:*******:.*** .**:**:*** :**:**:****:.:************:***** :* . .:::: * :***** ::.:**:**************** :**** * **:********:********:* *: :: .*.**:***************:****. .*:*.::** **: * ********::*::**:::*.:**.* ** ***.*:* **: :. ****.:::**:**:** : :*:***** :**:** .**:.**: ** **. :*::** :*: *** :: ** : *: *: *:* :** :*: :: ", "identical_positions": 351, "similar_positions": 227, "identity": "44.71%" }, { "cls_id": "homologset.agr.HGNC:16387", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2A716-1", "uniprot_id": "A2A716_MOUSE", "id": "A2A716-1", "name": "Oxysterol-binding protein", "aln": "MDFQER-DTPSLAESTQSS----KPSSTQQAS-----------ELWEVMEEPRG--RLGADDIMPERQ----EGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDIT-------KGKVHGSIDVRLSVMSIN---KKAQRIDLDTEDNIYH--LKIKSQDLFHSWVAQLRAHRLAQRLDMP-----------------------SATHRKAPGTQMLTAGSAS--ALPGVGPRE--KVSSWLRDSDGLDRCSHALSECQGKLQELHR--LLQSLESLHRIPSAP----VIPTHQTSVTTERPKKGKRTSRMWCTQGFAKDDTIGRVGR----------------LHGSVPNLSRYLESRDTSGPRG----------------LPPPDYAHLQRSFWALAQKVHNS----LSSVLVALTTERDRLRDLHQGSELSR-------------------MVVSEAPDGQRRLHSLSISSDTTADSFSSLNPEEQEALYMKGRELTPQLSQS--SVLSLADSHTEFFDACEVLLS-----------------------------------ASSSENEGSEEEESCASEITTSLSEEVLDIRGADR-------------------YQKGPCVPGIAVGPPRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRMADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFIFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSN--IHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPPPGGQCIWKPNSMPPDHERNFGFTQFALELNELTSELKRTLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRRVMEENNIVHQARFFRRQTDSSGKEWWVTNHTYWRLRAEPGYGNLDGAVLW", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0L2K0-1", "uniprot_id": "A0ABK0L2K0_RAT", "id": "A0ABK0L2K0-1", "name": "Oxysterol-binding protein", "aln": "MDFQER-DTPSLAESTQSS----KPSSTQQAS-----------ELWEVVEEPRG--RLGAEDIMPERQ----EGHLLKKRKWPLKGWHKRYFVLEDGVLHYATTRQDIT-------KGKVHGSIDVRLSVMSIN---KKAQRIDLDTEDNIYH--LKIKSQDLFQSWVSQLRAHRLAQRSDLP-----------------------NATHRKAPGTQTLTAGSAS--ALPGVGPRE--KVSSWLRDSDGLDRCSHALSECQGKLQELHR--LLQSLESLHRIPSAP----VIPTHQASVTTERPKKGKRTSRMWCTQGFAKDDTIGRVGR----------------LHGSVPNLSRYLESRDTSGPRG----------------LPPPDYAHLQRSFWALAQKVHNS----LSSVLVALTTERDRLRDLHQGSELSR-------------------MAVSEAPDGQRRLHSLSISSDTTADSFSSLNPEEQEALYRKGRELTPQLSQS--SVLSLADSHTEFFDACEVLLS-----------------------------------ASSSENEGSEEEESCASEITTSLSEEVLDIRGADR-------------------YPKGACVPGIAVGPPRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRMADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFIFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSN--IHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPPPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRTLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRRVMEENNIVHQARFFRRQTDSSGKEWWVTNHTYWRLRAEPGYGNLDGAVLW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BZF2-1", "uniprot_id": "OSBL7_HUMAN", "id": "Q9BZF2-1", "name": "Oxysterol-binding protein-related protein 7", "aln": "MDFQER-DPPFLPESAQSS----KPSSAQQAS-----------ELWEVVEEPRV--RLGTEGVMPERQ----EGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDIT-------KGKLHGSIDVRLSVMSIN---KKAQRIDLDTEDNIYH--LKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSL------------------PSTAHRKVPGAQLPTAATAS--ALPGLGPRE--KVSSWLRDSDGLDRCSHELSECQGKLQELHR--LLQSLESLHRIPSAP----VIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIGRVGR----------------LHGSVPNLSRYLESRDSSGTRG----------------LPPTDYAHLQRSFWALAQKVHSS----LSSVLAALTMERDQLRDMHQGSELSR-------------------MGVSEASTGQRRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQT--SILSLADSHTEFFDACEVLLS-----------------------------------ASSSENEGSEEEESCTSEITTSLSEEMLDLRGAER-------------------CQKGGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSN--VHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAVLW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AY80-1", "uniprot_id": "A0A8M3AY80_DANRE", "id": "A0A8M3AY80-1", "name": "Oxysterol-binding protein", "aln": "MDSVDH-NQSHMSGVEKVSSGWQKPSHSRSSSTASSRHSRLNVKDWEVMDDCPADLTITAENIQDANTPGICEGYLMKRRKWPLKGWHKRYFVLDKGILRYTKNQHDFS-------RGKMHGSLDVSLAVMSVN---KKARRIDLDAGDNLYH--LKAKSQDLYFIWVTKLSAHRMYKKNEAAHVHNGY---------LQVLSHTSNLSHKTSPMQDMGTSGSSMGENLQYVSPAVNGKVSAWLQTQE-PDFCGQELTRCQMELNELQR--LVQKLNSLESGQTVYNGDLQRMISMQNLSLDKPKK-KSAKIFGHSRTLSRVEGLGMPFRGITKSLSSSQLNSSSLLGTSVPSIPDYVSTPANSPAS------------------TSPESKKLHQDICSMSLKVHAS----LRTAHEALAQERQRLRDTWSGRDLHQN--------TSAQLNNLCSLAELDVNSRHTKIHKLSISSNSSDDSFRTVE---------QRKSVSSRCSSF--RAPSIADSVAEYFDACDELKC-----------------------------------ASSSEMSDESGLSDGSSNSEPYEAHAMASRKYRAS-------------------LSKAAAKPNTIKSTGRRTTLPAVCPDNSHVGLMTILYNNIGKDLSRVSMPAALNEPVCLLQRLCEELEYSDLLDTANHTDDPFQRMVYIAAFAISGYATAQFRNRYKPFNPVLGETFECIREDRGFRYISEQVSHHPPISACHADSDNFSFWQDQRWKNKFWGKSLEIMPTGMVNVTLKKYGDHYEWNKVVTCIHNVLSQQRYLEHYGEVIIQNLNSSVCTCKITFVKSRYWGADAARNQVQGQVLDQTGNVIHRFGGFWHEGIFCETLPVPQCIWKPNPQPKNYLLYYGFSSFAMEMNELVPELKPLLPPTDTRLRPDQRLLEEGKVEETDKKKDEVEEKQRERRKIMAKRGEEHIPRFFRKSLDAAGREVWLTNGTYWKIRENPGFANVNNLELW", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38713-1", "uniprot_id": "OSH3_YEAST", "id": "P38713-1", "name": "Oxysterol-binding protein homolog 3", "aln": "METIDIQNRSFVVRWVKCGRG--DVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDTKTLLDYT--TKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQEIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFNASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDK---IIIIDSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLNGTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRFVTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIVEETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAAS--PPSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYR-DKTRTLRKPFNPLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGD--KSHILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLANETT--HETIWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERR----NKGQDVEPKYFEKVSKNE-WKYITGPKSYWERRKKHDWSDIS--QLW", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: : : . : : . . : . : . ::: : .: :. * * . :: *:* ... . : .::. * : * :: * . .:*:. : :.: : *: *. * : :: . : : :: . :. . : : ::..: : * *: . :: * :: .*.*: . .: :... : . : . : : : * *. :: . .: . .. . : .: : ::. . * :* . : *.. .. .: : :. : :. .. : : * : . : : : .. * .. *:*** : : *.** .. .. ::: . : . : * . . ** :* .. .* .:* :*:***** ::**. ***: ** :.* :**: ** *.: ** : :* :* * * *****:*.**:* * * *** ***:***:**: * .*: :: .:******:*: * :.:.: *: :**.: .: ::*::: :*::* .*. ::. :.. .:* * *: :.. :*. :.. . : * * :.: . : **: . : :**:.*: ::**:. * **.**:***** * ***::: :: * .:*: **:** :.. .::*.: . : :**. * : .:.::. **", "identical_positions": 140, "similar_positions": 275, "identity": "13.77%" }, { "cls_id": "homologset.agr.HGNC:16388", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BXR9-1", "uniprot_id": "OSBL6_MOUSE", "id": "Q8BXR9-1", "name": "Oxysterol-binding protein-related protein 6", "aln": "MSSDE-KGISPAHKTSTPTHRSASSSTSSQRESRQSIHVLERTASSSTEPSVSRQLLEPEPIPLSKEADSWEIIEGLKIGQTNVQKPDRHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKAR-RIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYR-QNEIVRSPRDASFHIFPATSTAESSPAANVSVVDGKMQ--------------------PNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEE-----MDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWR---TKSVSKDTKIQLQEGPPAKGQFNTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPN-LCADI-EFQTPPSHLTDPLESSTDYTK------LQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQVVSEQDHNKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSES---TICDHVVSVNIIPSPDEPGEQ---IHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDES--YISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTLRNTKSSVCICKLTFVKVNYWNSNVNEVQGVVIDQEGKVVHRLFGKWHEGLYCGVAPSAKCIWRPGSLPTNYELYYGFTRFAVELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAAAEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LMF4-1", "uniprot_id": "A0ABK0LMF4_RAT", "id": "A0ABK0LMF4-1", "name": "Oxysterol-binding protein", "aln": "MSSDE-KGISPAHKTSTPTHRSALSSTSSQRESRQSIHVLERTASSSTEPSISRQLLEPEPIPLSKEADSWEIIEGLKIGQTNVQKPDRHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKAR-RIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYR-QNEIVRSPRDASFHIFPATSTAESSPAANVSVVDGKMQ--------------------PSSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEE-----MDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWR---TKSVSKDTKIQLQEGPPAKGQFNTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPN-LCADI-EFQTPPSHLTDPLESSTDYTK------LQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHNKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSES---TICDHVVSVNIIPSPDEPGEQ---IHANLPLSQQVVNESRLSMSESVSEFFDAQEVLLSASSSENEASDDES--YISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNVNEVQGVVIDQEGKVVHRLFGKWHEGLYCGVAPSAKCIWRPGSLPTNYELYYGFTRFAVELNELDPVLKELLPPTDARFRPDQRFLEEGNLEAAAAEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BZF3-1", "uniprot_id": "OSBL6_HUMAN", "id": "Q9BZF3-1", "name": "Oxysterol-binding protein-related protein 6", "aln": "MSSDE-KGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKAR-RIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYR-QNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQ--------------------PNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEE-----MDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWR---TKSVSKDTKIQLQ-------------------------VPFSATMSPVRLHSSNPN-LCADI-EFQTPPSHLTDPLESSTDYTK------LQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSES---IICDQVVSVNIIPSPDEAGEQ---IHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDES--YISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BJS4-1", "uniprot_id": "A0A8M2BJS4_DANRE", "id": "A0A8M2BJS4-1", "name": "Oxysterol-binding protein", "aln": "MSRHQSRTTSLEEKVATPIHR----STAPLQKSSTPTHKSASSSSSSQRDSR-------------QEPDSWEIIEGLRIGQTHVQRPEKHEGFMLKKRKWPLKGWHKRFFVLDNGILKYSKSPVDIQKGKLHGSIDVGLSVMSIKKRAR-RIDLDTEEHIYHLKVKSPDVFDLWVCKLRHHRLFR-QNEIVRSPRDATLRTFPPSAGAESPQNTPSSTHPKKQGK-------------------PSSFPWQLPPSCSN--------GQSKVAAWLQESEE-----MDKCAEELAYCQSSLLELNQLLQSLEILQRTQSAPNFTDMQSNCVDLSKKEKRVSRRWR---TKSVSKDAKLQQQVQS--------------LPQSHSAKVPLSASMSQVRLHSSNPN-LCAELADFQAPVTRLTDGIDSAGDYIK------LQEDFCIIAQKVHSLLKSAFNTVAIEKEKIKQVLLDHEQ-TGQSNQIVTLRRSLSQALSQNAELKTRLNRIHSES---VLSEQVVSVNIISSPDEACEP---LHVGLPLSQQVSNESRLSMSESVSEFFDAQEVLLSASSSENEASDDES--YVSDVSDNISEDNASVTDNVSRQMPNGELASSMFRNGRRPCLPAPAPDTSNINLWNILKNNIGKDLSKVSMPVELNEPLNTLQHMCEELEYTELLDKAAQTDDPYERMAIVAAFAVSGYSSTYYRAGSKPFNPLLGETYECIREDKGFCFFSEQVSHHPPISACHCDSQNFTFWQDVRWKNKFWGKSMEILPIGTVNVMLPSYGDHYEWNKVTTCVHNILSGRRWIEHYGEVTIRNTRSTTCICKLSFIKGNYWSSNVNEVQGSVMDQEGRVIHRLFGKWHEGLYCGVPPSAKCIWRPGSMPTDYELYYGFTRFAVELNELFPEMKELLPPTDARFRPDQRFLEEGNVQMATAEKQRIEEQQRNRRKWMEENNIKHQPRFFKKVMDSNQRERWVSNSMYWELRKDPGFLKLENPELW", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38713-1", "uniprot_id": "OSH3_YEAST", "id": "P38713-1", "name": "Oxysterol-binding protein homolog 3", "aln": "METIDIQNRSFVVRWVKCGRGDVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDTKTLLDYTTKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQEIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFNASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDKIIIIDSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLNGTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRFVTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIVEETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAASPPSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYR-DKTRTLRKPFNPLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLAN--ETTHETIWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERR----NKGQDVEPKYFEKVSK-NEWKYITGPKSYWERRKKHDWSDIS--QLW", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. : : * : . : .. ** : ..* . : : ::..:*. : . * : :.. : .: *: : . :: :. :* :. .: :::. :: * : :.. . : * : : . :*: : *.*.:. .. : :.: . : . .* : * : :. .:: :* * . :. : .. :: *: * : *. : *: ..:*.* .: . :: :. : ..:. : **...: : *. . :: *.. .*: : : :.. : :.. : : . *. **: :*: . . .* * :. . .: : : *. **. .:. :* .:* ** : :. *.:. ** .:. * ** : :..* ::..**.: .. . : . .: .:::. ::. :. : . :* . : :. * . :* .* .:*::*:*****.::*** ***:. ** :.* :**: ** **:: ** : .* :* * *: *****:*.**:* **** ** ::**:***:**: * ..: :: : .:******:*: * :.: : . *: : *.: ** ::*:::*.*::* .*. ::.::. . : *: :*. ...: * *** :.* .: : **. *.: :: : ****:*: :***: * *****:*:*** * ****:: * * ::*: **.** ::. . *::*:** . *: : .. . *** **. .: .:. **", "identical_positions": 175, "similar_positions": 318, "identity": "17.4%" }, { "cls_id": "homologset.agr.HGNC:16389", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BKC6-1", "uniprot_id": "HBAP1_RAT", "id": "Q5BKC6-1", "name": "HSPB1-associated protein 1", "aln": "MEAGCEGSSPQTLGERTMGEEGERVKPFTPEKAKEVIMSLQQPAIFCNMVFDWPSRHWTAKHLSKVLEGKQIRFRMGLRSTGTVPQFETECSYVDATLEEFLAWNCDQSR-ISGPFKKYDHSKFWAYADYKYFVTLFEDKTDVFQEVMWSDFGFPGRNGQESTLWIGSLGAHTPCHLDSYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFQKA--RRHMVTLSPGQVLFVPRHWWHYVESLDPVTVSINSWIELEEDHLARVEEAVTRMLVCTLKTAEDPHHPRTWLNPTEVEETSHEVNSCYLNSAVCAFFDHCERAKEVEMQAPRANGEEPGVQ-----EHMEVEQARDPSSDVGAGKQEAASPFGPDLVPVTPASEE----RGGALEGDSQECTSRNGEHCAELPCARRQQASKGA--RAEAGQSAPRYPVAPSRVFVSTDDLLDCLVNPQVTRMVAQLLIQG-KSL---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BK58-1", "uniprot_id": "HBAP1_MOUSE", "id": "Q8BK58-1", "name": "HSPB1-associated protein 1", "aln": "MAAGCEGIAPPTLGERTVGEEGEPVKPFTPEKAKEIIMSLQQPAIFCNMVFDWPSRHWTAKHLSKVLEGKQIRFRMGLRGTGTVPQYETECSYVDATLEEFLTWNCDQSS-ISGPFKDYEHSKFWAYADYKYFVTLFEDKTDVFQEVVWSDFGFPGRNGQESTLWIGSFGAHTPCHLDSYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKCFPQFQKA--RRHMVTLSPGQVLFVPRHWWHYVESLDPVTVSINSWIELEEDHLARVEEAITRMLVCTLKTAEDPHHPRTWLNPTEVEETSHEVNSCYLNSAVCAFFDHCEKAKAVELQVLSANGAEPRVQE----EHMEVEQAQGPSLTSRAEKQEAVSLFGPDLIPVTPASEE----RGGALEGDSEESVSSNGGHFAELPCARRQQTSKGA--SALTEPLAPRGPMAHSRVFVSTDDLLDCLVNPQVTRMVAQLLIQG-KSCDTF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96EW2-1", "uniprot_id": "HBAP1_HUMAN", "id": "Q96EW2-1", "name": "HSPB1-associated protein 1", "aln": "MAAGSEATTPVIVAAGAGGEEGEHVKPFKPEKAKEIIMSLQQPAIFCNMVFDWPARHWNAKYLSQVLHGKQIRFRMGMKSMSTVPQFETTCNYVEATLEEFLTWNCDQSS-ISGPFRDYDHSKFWAYADYKYFVSLFEDKTDLFQDVKWSDFGFPGRNGQESTLWIGSLGAHTPCHLDSYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKA--QRHAVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHLARVEEAITRMLVCALKTAENPQNTRAWLNPTEVEETSHAVNCCYLNAAVSAFFDRCRTSEVVEIQALRTDGEHMKKEELNVCNHMEVGQTGSQNLTTGTDKPEAASPFGPDLVPVAQRSEEPPSERGGIFGSDGKDFVDKDGEHFGKLHCAKRQQIMSNS--ENAIEEQIASNTTTTPQTFISTDDLLDCLVNPQVTRIVAQLLIQG-RSL---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6AXL5-1", "uniprot_id": "HBAP1_DANRE", "id": "Q6AXL5-1", "name": "HSPB1-associated protein 1 homolog", "aln": "MSS----------------------KPFTPEEARRIVQVLQKPAVFLNMTTDWPALHWTVEHLSACLT-KRIRFRVGKRSEDMAPLFETECSYVEATIKEFLSWTANDGEPLVGPFLDYHCKEFWAYADYKYIAQLFQDKPAMFQDVVWSDFGFPGRDGRDSTLWIGTQCANTPCHLDSYGCNLVFQIQGRKRWHLFPPDDTACLYPTRVPYEESSVFSHVNVIRPDLKKFPAYGRA--RLYTVTLQPGQVLFVPRHWWHYVESVDPVTVSVNSWIEMDMDDEARVAEALTKTIVCAVKSSPSLDNSDQWLNPTEDGVSSHDENMQYLNLAVKVCMN--KKRDDIEDQPK----------------AEAVKRDFSGVLKSPASPPSLVS-FGPHLIPVHLTEKP---QCSSTKDSCCFSCTDSPQCQITTKDQDKLRSDNKLGQRSGQSVLQDTENPGGSGEMHISTNDVLECLVHPDVIALVTRLIMCRQRELHS-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VB06-1", "uniprot_id": "Q9VB06_DROME", "id": "Q9VB06-1", "name": "", "aln": "--------------------------MELSSKLRDLILNTHVPLVLEQFPLKWECFEGSLHDWCKRFD-KEATCLPAFELMALADSSTPQWERKRTKSSQLLNMQQFLRK---YGVLDGDSTHWAAYQYKKADEVPLSCR----SGIGFSSFGFP-DIGNDYRFWLGSEQANTPCHYDTFGVNIVVQVHGCKSWLLFPPETP--LQSTRIPYEETSVYCLENFYAPDPAKISSYEHLGRQAYHCNLQPGNVLIVPRHWWHYVEAKS-TSLSVNYWVPLKVDMDLILDEFLVMHIVESFVRGESNQVKQYLLNPNQLDNVSTKP--------------------------------------------SDLFAQFEQAVQNLESGKSTRQLYDTDYISQADWKTL-------------LNSINLSVRPLEVMPHEEYKLLLNAN----SKRFRVAANPPETTPISSNCELLVSSMCAPRVIAEMKREFFRRLGKSNSL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..: : :: : * :: :: .* . . . . . : *. . . . . . :. .::* . . . ..: ** * :. : . : :*.**** *.: :*:*: *:**** *::* *:*.*::* * * ****: . * .**:****:**:. *. ** :. : : : : .*.**:**:**********: . .::*:* *: :. * : * :. :* :. . . . ***.: * : . . :... :. . . . . : . . . . : ::..: * * : : :: . ", "identical_positions": 71, "similar_positions": 121, "identity": "14.29%" }, { "cls_id": "homologset.agr.HGNC:1639", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P08921-1", "uniprot_id": "CD2_RAT", "id": "P08921-1", "name": "T-cell surface antigen CD2", "aln": "--MRCKFLGSFFLLFSLSSKGADCRDSG---TVWGALGHGINLNIPNFQMTDDIDEVRWERGS--TLVAEFKRKMKPFLKS-GAFEILANGDLKIKN-LTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMIYWECSN--ATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTN-LRAPFKCKAVNRVSQESEMEVVNCPEKGLPLYLIVGVSAGGLLLVFFGALFIFCICKRKKRNRRRKGEELEIKASRMSTVERGPKPHSTQASAPASQNPVASQAPPPP-GHHLQTPGHRPLPPSHRNREHQPKKRPPPSGTQVHQQKGPPLPRPRVQPKPPCGSGD-VSLPPPN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P08920-1", "uniprot_id": "CD2_MOUSE", "id": "P08920-1", "name": "T-cell surface antigen CD2", "aln": "--MKCKFLGSFFLLFSLSGKGADCRDNE---TIWGVLGHGITLNIPNFQMTDDIDEVRWVRRG--TLVAEFKRKKPPFLIS-ETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPN--TTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTN-LNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAA--AQNSVALQAPPPP-GHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P06729-1", "uniprot_id": "CD2_HUMAN", "id": "P06729-1", "name": "T-cell surface antigen CD2", "aln": "MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEK-DTYKLFKNGTLKIKH-LKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCIN--TTLTCEVMNGTDPELNLYQDGKHLK-LSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPAST--PQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PSH0-1", "uniprot_id": "A0A8M9PSH0_DANRE", "id": "A0A8M9PSH0-1", "name": "", "aln": "MSLPVLRVSPAMFKKKIQALTLKTEAAESP-CVYKKVGENVVIELMIDQLNPG-DHLIWKKSQ----MKVFEKKNSAVKTKNEGFDIDHSGSLIIEN-IQTDKSGTYKAEVFNSDGKSKTKMEIQLCVQEPVSEPSITVQCGDEGVHLSCIFLSGTEASVSWMKNGQKTDKTAAVLHISWSELELGDSYSCTVSNRISLKSAKDVQPACSSTENTTNADGD-------------------RKKDEDGGGKGENNNDDGQSFLFGLDLWMVVLVAVAG--GVFLILFIICVVCICCRRRNKSKAEEEKEFRLAPLMPDNSSQPEEQQYMQQSESLRPSKSQRPLPPLPNA---------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :.. :: .:.. . : :*..: ::: *:. . *.: * : : *.:: .. . :.: .* * *:: : :... *:. ::.:.* : ::: : * **:* * * : . *:* .:.**: .:. :. * :.* . * :* :* : . .. * :::.. :.*: : . .: : : .: .* .. . *. * **. . * :* ** . ", "identical_positions": 36, "similar_positions": 102, "identity": "10.06%" }, { "cls_id": "homologset.agr.HGNC:16390", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ADT7-1", "uniprot_id": "D4ADT7_RAT", "id": "D4ADT7-1", "name": "Nucleotide-binding oligomerization domain-containing protein 1", "aln": "MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPE-EVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSS-QLPDCAVTLTDVFLLVTEVHLNRTQPIS-LMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFN--QVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITSEGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTAQLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BHB0-1", "uniprot_id": "NOD1_MOUSE", "id": "Q8BHB0-1", "name": "Nucleotide-binding oligomerization domain-containing protein 1", "aln": "MEEHGHHEMEGTPLGCHSHIKLLKINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTKPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLTSTAKFFFHFRCRMFSCFKESDMLSLQDLLFKHFCYPEQDPE-EVFSFLLRFPHTALFTFDGLDELHSDFDLSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFQTVFEGSSSQLPDCAVTLTDVFLLVTEVHLNRPQPSS-LVQRNTRSPAETLRAGWRTLHALGEVAHRGTDKSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQGQ-SYEFFHLTLQAFFTAFFLVADDKVSTRELLRFFREWTSPGEATSSSCHSSFFSFQCLGGRSRLGPDPFRNKDHFQFTNLFLCGLLAKARQKLLRQLVPKAILRRKRKALWAHLFASLRSYLKSLPRVQSGGFN--QVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVQELQPCFSRLTVIRLSVNQITDTGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLKHLKLGKNRITSEGGKCVALAVKNSTSIVDVGMWGNQIGDEGAKAFAEALKDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTVIWLTKNELNDESAECFAEMLRVNQTLRHLWLIQNRITAKGTAQLARALQKNTAITEICLNGNLIKPEEAKVFENEKRIICF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y239-1", "uniprot_id": "NOD1_HUMAN", "id": "Q9Y239-1", "name": "Nucleotide-binding oligomerization domain-containing protein 1", "aln": "MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPE-EVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSP-QLPDCTMTLTDVFLLVTEVHLNRMQPSS-LVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFN--QVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RMD1-1", "uniprot_id": "A0A8M1RMD1_DANRE", "id": "A0A8M1RMD1-1", "name": "", "aln": "---MGSYKTEN------SYLKLLTVHRELLVEQVKNTQCILDNLLMNSFICTEDIEIIQRSSTKTDQVRKILELVQSKGEECSAYFTQILYEAYDAYIDLRPWFDEIQYTPLDTIKAIPVVNTDPISKYCEKLRYELGRDTQFITSYSKSEETPLEDLYTDTQMELLNDTGESLGYLQNLDQLLGD-QGVFNPQAETIFITGDAGVGKSIMLQKLQNLWSRRELKTGAKFFFKFRCRAFSAFKETDEISLKDLIFKHNCYPDGDPDNEVFAYILRFPETVVFTFDGYDELQMDFDLDNVPETVSPEEKTRPLLLLMNLLCGKLLKGSRKILSARSGTEIQSRVIRKKVFLKGFAPEHLKRYLALHFPEQEHRMLVSDQLDANPHLCGLCSIPLFSWIILKSFKHLQSVYDDFE--LPGSCITLTNVFLLLSEVFLGHSTARPGLLRRTLRCPTETFKAGEQKLSGFARLALHGIETSKLVFTLDEAVCCGLNDEDLQFGFLRPASHYDS-SSASSFEFLHETLQAFLAAFSLVLDAKLNPESILKFFSKCKYK-KSSRLSCIP------CLKNTKPRESDAFQTN--FQFTNLFLCGLLSKSNAALLEHLVPPSALKQKRKILKSYLSNSVKTHLKSLPRSPSTDIEGDKVHAMPNFLWMLRCIFETNSEDVAKMTANGISADYIKIAFCNIYSADCSALNFVLHHRRKHLGVDMDNNNINDYGVKQLRPSFSKMTVVRFCVNQLTDSGIEVLAEELIRHKIVKVLGLYQNHITDVGAKQVAKIIEECPHLRTVKLGCNNITSVGGKYLASAIHKSKSIFDIGMWGNCIGDEGAEAFAEALKNHPSLTNLSLSANGITSHGGRSLAQTLKENTSLHIVWLIQNKISDDAASDLAEAFRSNSSLTHLMLIDNEFTIDGARQLSEGLKDNTTLKEVNIKGSRISEAEEHLYQGDRRLRFH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : * .:::** :** ** :::****::**** *.::.:** **: ..*:.*:*****:******** * :* :* : ***:*** *: ** ::* :: :*****:*:* ::**:.****::*: .*::.*: **: * ** ***:. ..*.** * .* **.. *::* :.**:*: ********::**:**.**: .* : .****:**** **.***:* : *:**:*** ***: **: ***:::****...:***** ***: *:*:..**:: .* * ::**:** ***.*:****: *:*:**:* *: :.:****:*:**:*.**: * ***: : : .**:***:**.**.:***.***::.*:*:::.::. **.. :***:****::**.*.: . . *::*. *.*.**::** .* .:..:* :* : * :** :*. .. *:: *:*:****. .. .. . *:**:* *****::** ** * ::....:*:** : :: ** . ** . * *:.: ************:*:. **.:*** : *::*** * ::* *:: :****** .:: :*:***.*:******:**:*:.*.:::*.**.*:*:*:::** *******.***** ::*.:*:****:*****::*:*.**::**:*:.***:** *::**.*** ::***. ****:*:***:**: *::*::** * :*** *.*** **: :* *:::*.** ::***** :*****:******::*****.***: ***:..**:***::*::**:* ::** :*::.*: *. :** :: *.:* ** **:*.:* .*: **: .*:.** :.*: ::*. *. * ::::.::*: .", "identical_positions": 441, "similar_positions": 322, "identity": "46.03%" }, { "cls_id": "homologset.agr.HGNC:16391", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EPY0-1", "uniprot_id": "CARD9_RAT", "id": "Q9EPY0-1", "name": "Caspase recruitment domain-containing protein 9", "aln": "---------------------MSD------YENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQD-------LTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYDLAMRLAHLSEEKGAALMRNRDLQLEVDQLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWDLQQERDLLQARVQELEVSVQEGKLHRNSPYIQVLEEDWRQALQEHQEQASTIFSLRKDLRQAEALRTRCMEEKEMFELQCLALRKDAKMYKDRIEAILQQMEEVSIERDQAMTSREELHAQCAQSFQDKDKLRKQVRELDEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILS--SDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFVVLNKKHLSQT-HDTVPSSSEPPEKERRRLKESFENYR------RKRALRKMQNSWR-QGEGDHGNTTGSDNTDTEGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AIV8-1", "uniprot_id": "CARD9_MOUSE", "id": "A2AIV8-1", "name": "Caspase recruitment domain-containing protein 9", "aln": "---------------------MSD------YENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQD-------LTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRNSPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRKDAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILS--SDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFMALNKEHLSLT-HGMGPSSSEPPEKERRRLKESFENYR------RKRALRKMQNSWR-QGEGDRGNTTGSDNTDTEGS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H257-1", "uniprot_id": "CARD9_HUMAN", "id": "Q9H257-1", "name": "Caspase recruitment domain-containing protein 9", "aln": "---------------------MSD------YENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQD-------LTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLS--SDLEDGSPRRSQELSLPQDLED-TQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR------RKRALRKMQKGWR-QGEEDRENTTGSDNTDTEGS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3ASN6-1", "uniprot_id": "A0A8M3ASN6_DANRE", "id": "A0A8M3ASN6-1", "name": "", "aln": "MCNVHLTLKTCYQTALNKPTAMSDGPGVFEVEEDDECWARLEDYRMLLIKTIEPSRITPYLRQCKVLSSEDEEQIYNDPSLVIRRRKVGVLLDILQRTGLKGYEAFLESLELDYPDVYRKITGKEPARVFSVLIDTAGECGLTQFLMSEVSRLQKLAQDERRARLEVSAQVKEQHETIRQLQLCENELHKQQERVHRIREERERMCEEARTLKDENYRLMHDLTRLSEEKNCALMCNRDLQLEIEKLKHSLMNAESDSKIQRKKTVNLKNAMEQRPSPEIIWKMQRQNDLLKARIQELESASKVQTPEQEKPDSQTLEDFKQQSQAQYQELVNDLYNLRRDLHDAEKLRDKYREEKDELELKCLMLKKDSKMYGDRMEDILKQLEEVIKERDKAICTREEYHLENSKNLQDKDQYRKQIREMGERYDELQVQLFRTQGEVLALQATLRKQKSPIRVNSGESSLLSSFESSTGLLTFYPQLKSSEEESRERGEKDMSEESQSQTSGEFNSCLFSERRVSGEDISDNCKNNRKCNFHYRSYSPNVVLDRKRALRTKRCTDKDNMQGLLDNTTGS---DTDGM", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** *:*****: **.:*: * ..*:**************..:****: .**.****:************** *** ******** **::*:*:**********::**::**.****:**:** :*** .** ::* :..:.: *::*:: :. *:*:****:*::** * . * : *:*** * *:: ****..*** *******:::*:****:**.*.*::**:*::*::******* *::*.:*::. **:**:***: : : . .:..* *.**: :*: ::*: .. ::.**:**::.* * : ***: :**:** *:**:*** **:* ** *:*** ***:*: :*** * : ::.:*:** ** :**:.*: ****:*:*: :..:** :. *::*: : * *.* .. : *:: :*:. : * : . . .*. . : . : .. . *:.*: : :..* ******. : : : : ***** **:* ", "identical_positions": 242, "similar_positions": 170, "identity": "41.72%" }, { "cls_id": "homologset.agr.HGNC:16392", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ER64-1", "uniprot_id": "OSBL5_MOUSE", "id": "Q9ER64-1", "name": "Oxysterol-binding protein-related protein 5", "aln": "------------------------------------------MKEEAFLRRRFSLCPPASTPQKTDP-----------------------------------RKVPRNLLLGCENELGPITPGRDMESNGPSQPRDE----------------------------------EPQTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDALKAQKENYRQEKKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTP--KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLYGLPTSATIP-DQDLFPLNGSALEN----DAFSDKSERENAEDSD-AETQDHSRKTNESGSDLLDSPGGPWR-GTTYVEQVQEELGELDETSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLGKLSDYYYHGDLLSRAAAEDDPYCRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCRWLHPQTNSHTFYIAEQVSHHPPVSAFYVSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRK------EEYTLTMPYAHCRGILYGTMTMELGGKVNIECEKNNLQAELDFKLKPFFGSSANINQISGKIMSGEEVLARLTGHWDRDVFIKEESSGGTELFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIREGDQHKATQEKSVLEEAQRQRAREHQQSLTPWKPQLFLLDPLTQEWRYRYEDLSPWDPLKDIAQYEQDGILHTLQRETMSGQTTFLGSPDSRHKRPSSDRRLRKASDQPSGHSQVTESSGSTPESCPDLSDE----DFVPGGESPCPRCRREVHRLKMLQEAVLSIQEAQQELHRHLSTMLSSTVRAGQAPAPSLLQNP---------------RSWFLLCIFLTCQLFINYILK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZYG1-1", "uniprot_id": "A0A8I5ZYG1_RAT", "id": "A0A8I5ZYG1-1", "name": "Oxysterol-binding protein", "aln": "-------------MCREQRWALVCGQKRLELLAPQKPPSTHTMKEEAFLRRRFSLCPPASTPQKTDP-----------------------------------RKLPRNLLLGCENELGPITPGRDMESNGPSQPRDE----------------------------------EPLTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDTLKAQKENYRQEKKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTP--KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGETVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLYGLPTSATIP-DQDLFPLNGSALEN----DAFSDKSERENADDSD-AETQDHSRKTNESGSDLLDSPGGPRR-GTTYVEQVQEELGELDETSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLSKLSDYYYHGDLLSRAAAEDDPYCRIKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWLHPQTNSHTFYIAEQVSHHPPVSAFYVSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRK------EEYTLTMPYAHCRGLLYGTMTMELGGKVTIQCEKNNLQAELDFKLKPFFGSSTSINQISGKITSGEEVLARLTGHWDRDVFIKEEASGGTKLFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIHEGDQHKATQEKSVLEEAQRQRAREHQQSLTPWKPQLFTLDPLTQEWRYQYEDYSPWDPLKDIAQYEQDGILHTLQRETMSGQTAFLGSPESRHKRPSSDRRLRKASDQPSGHSQVTESSGSTPESCPDLSDE----DFVPGNESPCPRCRREVHRLRMLQEAVLSIQEAQQELHRHLSAMLRSTVRAGQAPAPGLLQNP---------------RSWFLLCIFLTCQLFINYILK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H0X9-1", "uniprot_id": "OSBL5_HUMAN", "id": "Q9H0X9-1", "name": "Oxysterol-binding protein-related protein 5", "aln": "------------------------------------------MKEEAFLRRRFSLCPPSSTPQKVDP-----------------------------------RKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE----------------------------------GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTP--KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLEN----DAFSDKSERENPEESD-TETQDHSRKT-ESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRA------EDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSP---------------RSWFLLCVFLACQLFINHILK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FGK0-1", "uniprot_id": "E7FGK0_DANRE", "id": "E7FGK0-1", "name": "Oxysterol-binding protein", "aln": "------------------------------------------MKEENLFRRRFSLCPTATSPPKIDP-----------------------------------RVLTRNLSYGGDNELYPLSPGNETERNGLPLLRDE----------------------------------VSPARSPSS---VSESRMFIGLEKESSSPTEKLARKESLKVQKKNYRQEKKRVAKELFSALKDPSVVIMSNWLKIRGTLKSWTKLWCVLRPGILIIYKTP--GSDHWVGTILLNACKLIERPSKKDGFCFKLYHPMDKSIWAMKGPEGETVGSITQPLPSNYLIFRAASESDGRCWMDALELALSCSSLSKM-TAKSCRDGDLSSSSESS--HILQLLQSSALT-DQELLQLNDSMLENNMENDANSDKSEREAHEDSDNAANENGGRLTEESDMDQSDD---VCLQATGFVEEAHEEMGEAGEASQVETVSDENKGLIWTLLKQLRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADLLSKAVTEESPYGRMKQVLRWYLSGFYKKPKGLKKPYNPILGEMFRCCWLHPQTDSCTFYIAEQVSHHPPVSAFYISNKKDGFCISGSILAKSKFYGNSLSAILDGKARLLFLTRD------EEYVITMPYAHCKGILYGTMTLELGGKITIECEKTQCYTELEFKLKPFLGSSCNVNQISGKIRIGEDILATVEGHWDSKVHLIEKKTGHQEVLWNPGPDIRRQRLKKRVVPIDQQEAFESERLWQHVTQAINDKDQNRATQEKFVLEEAQRQEARERAER--AWNPRLFTLDADTNEWHYKHADTKPWDPERCLVQFEKDGIIQTKEKSQRRRNRYSYSQDWAGQQKVRVNGKHRKSSSQPSSCSQNTESSSTTPEPNHESSDN-------EGFMNQCARCSKEVKDIALIEASVAAIQKTQQDIQRNLSALGRQIARHKTAEESKSLSG----------------RHFLILCMLLLFQLLINHVFT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4JCZ0-1", "uniprot_id": "A0A0B4JCZ0_DROME", "id": "A0A0B4JCZ0-1", "name": "Oxysterol-binding protein", "aln": "MQQPATPSTPVNNAPSATPSAASGPAASAPAVASSTPIRINSAKQQGAAGGGDTLAHPATPHSHSMPGTPHQQPQSSSVPTGGHLLQLQAPLPSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGISITPPNSAGLRQSTVFDFKFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFNDHDLDADSQNE----APNAVMSGLESESESDPAEPAQDDVVDQQCVE-------------TSYVPFTEEEFGEQGE--QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRG------ECYTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYG-QWLYKYADLRPWDSRNDVRQYECQ--FKVLTQTRHKSVPIVHGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSDSSQSPQGAVKRSSSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYALIGLAFSLILRWLFK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q02201-1", "uniprot_id": "OSH6_YEAST", "id": "Q02201-1", "name": "Oxysterol-binding protein homolog 6", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSKKLTVGSDSHRLSKSSFSS----NKSSHSATKDQPIDTD-----------------------------------------------DIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLP-NKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPN--FQADIEFKTKGYVFGTYDAIEGTVKDYDGN-AYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESP-LRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVD----------EDP-EKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQKKMIENEKQNPAKQ--------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P38755-1", "uniprot_id": "OSH7_YEAST", "id": "P38755-1", "name": "Oxysterol-binding protein homolog 7", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALNKLKNIPSLTNSSHSSING----IASNAANSKPSGADTD-----------------------------------------------DIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLP-NKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPK--YQVDIEFKTKGFISGTYDAIEGTIKDYDGK-EYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFP-LAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEG----------TDKHEEQIRSILETAPILPGQTFTEKFSIPAYKKHGIQKN--------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . ::* ::: :..:.:: :: *::** **:::.****:** :*:* :::: . :.* .* :.. *: *: ***:.:: *:.:*** **:*** * . * * . . ::**:**.***** .*:. :..: : : .**:* *** :*:::* : : :* * *. : * .: :*:* *.: :***.:: * : .:::** * :. .: * *: : *:*: : : . . . * :. * **.:**::*: *: :: **:** :*: ** *::: . . ** : * . * . . : . . ", "identical_positions": 89, "similar_positions": 128, "identity": "8.73%" }, { "cls_id": "homologset.agr.HGNC:16393", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CIS0-1", "uniprot_id": "CAR11_MOUSE", "id": "Q8CIS0-1", "name": "Caspase recruitment domain-containing protein 11", "aln": "MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLEDEKKQLSLIRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPRKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDNGSLDQSLPRHLPATIISQNLGDTSPRTNGQEADDSSTSEESPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQALMRTVKGHEEDFTDGSPSSSRSLPVTSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPHRSTVEEDNDSCGFDALDLDDENHERYSFGPPSIHSSSSSHQSEGLDAYDLEQVNLMLRKFSLERPFRPSVTSGGHVRGTGPLVQHTTLNGDGLITQLTLLGGNARGSFIHSVKPGSLAERAGLREGHQLLLLEGCIRGERQSVPLDACTKEEARWTIQRCSGLITLHYKVNHEGYRKLLKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKCDDVVHVLDTMYQDRHEWLCARVDPFTDQDLDTGTIPSYSRAQQLLLVKLQRLVHRGNREEADSAHHTLRSLRNTLQPEEMLSTSDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPENELSRNLTLIPYSLVRAFHCERRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVTRDEFLRKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGIGCVRDLIKCKVYPIVLLIRVSEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKTIWVDEDQL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZNJ6-1", "uniprot_id": "A0A8I5ZNJ6_RAT", "id": "A0A8I5ZNJ6-1", "name": "Caspase recruitment domain-containing protein 11", "aln": "MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLEDEKKQLNLIRVELLTFQERYYKMKEERDSHNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSGSLDQSLPRHLPATIISQSLGDTSPRTNGQEADDSSTSEESPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQ-----VKGHEEDFTDGSPSSSRSLPVTSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPHRSTVEEDNDSCGFDVLDLDDENHERYSFGPPSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSGGHVRGTSPLVQHTTLNGDGLITQLTLLGGNAHGSFIHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDACTKEEARWTIQRCSGPVTLHYKVNHEGYRRLLKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKCDDVVHVLDTMYQDRHEWLCARVDPFTDQDLDMGTIPSYSRAQQLLLVKLQRLVHRGTREEADSAHHTLRSLRNTLQPEEPLSASDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPENELSRNLTLIPYSLVRAFHCERRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVTRDEYLRKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGISCVRDLIKCKVYPIVLLIRVSEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKTIWVDEDQL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXL7-1", "uniprot_id": "CAR11_HUMAN", "id": "Q9BXL7-1", "name": "Caspase recruitment domain-containing protein 11", "aln": "MPGGGPEMDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQ-----AKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQRKTIWVDEDQL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****** ************:***:*********************************************************************************************************************:************: *********:.* ********************:***********************************************************************:***************** *****************************************:*******.***************************************************************************************************************...*******:**.*****.:**:*******************************:******************:*::*:** .*****: **.****. ***:*.**:**** ********************** **************** ***.*****:.********.*************************:*************** *****..* *********.* :*********:***:**********:**************************:******:******** :************:*:*:***************************:*********** ********************:*** ********************:***.***.*.:*****:********* **:**************:***********************************:*************:******.**.:**:**********:************:*******:**********************:**:***************:****.********************.*.*****.::*****:***.******************************************.:**.********:**** **************", "identical_positions": 1055, "similar_positions": 82, "identity": "91.03%" }, { "cls_id": "homologset.agr.HGNC:16394", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZVT3-1", "uniprot_id": "D3ZVT3_RAT", "id": "D3ZVT3-1", "name": "", "aln": "MASEGASSEIIEKQRTKLLSVLQQDPDSILDTLTSRRLISEEEYETLEAITDPLKKSRKLLILIQKKGEDSCCCFLKCLSNAFPQSASTLGLKQEVPRQG---TGEVVEVSRGLEDPFSLGTITPEIAELS---EEKECPGLGAPEFFTCKESSHREPEVPSWENQEGRGAQQVTAPRSVKGVEYEVPASISLLSDGQRYEEPDDSLYLEEGEGEESLGYPED---VLEEGAGDDPQCFVYDSEEECEYEENMGSSGEDSSCD--DTSETCVPLEGEKSAEERKRVFQHVLSCLNMDRNRKLLPEFVRQFSIDRGCEWTPKTPGDLAWNFLMKVQALDSTARDSILRPEVAGEENEELPAG-IEKLGIGDPQTIHPLDVLCACMLCADSSLQREVMSNMYQCQFALPLLLPDAENNKNLLMVGAMKDLKQ-PSAQSSGGPLRETDTFLGLTKMPVISFVRLGRCSFSKSRIVNTLLSSSQQKPYPIFLHQDLSVPVLPRQISDGLVEVTWCFP-DKLLKESPHAFQKPVAVANLRGDLESFWIQFGFLVEVSSGLFFFTDCLGEKEWDLLMFLGEDTIERCYFILSPQAKESEEAQIFQRILKLKPSQLLFWEAEEAGDRRKTMEALQAALQEVMSSP-LRCVSLEEMASLARELGIQVDQDFEVTQDIQVSP-----TTVEGENQQPCSQTKSPAESGAQEPIREPGAQCDDSQNAPVFHQTPVYMPYPAHPWPLPIKAGGNFYHVPLNAPWVMGSHFGSQQRAKWFFPFPHQNTSVHSRGQNFSIKYFQPWRCYSRGRFTNCSAKSQQNQ-NGPFGRSQR-QTS----HPENRQTSRTRQRSGTAASHVGHIHSSGSQATKATGKPHSEKARAQGMQLTKAAGKSIRTQSHIKHPHPQPCQPAGAIQERIIPTSHQEAQRTTQGRPSDLAFKPGSQSTSGNKHSSASQYNSHPPNFQSKHFQPKPFQPVP-----SHSQPSQAKPTHLNPSPANYTHVQPSHAKPTHSKAFQAN-------SHHPHPSHAKPTHLNPSHANPTHVQPSHAKPTHSKAFQAKP------------------TPSQTSWSQANSNHPHPSLAKPSHPNPSHAN----------PTHVQPSHAKPAHLQSSQTKPSPSQSTQFTAHKPQQSQSKPSQQRPSQPKSSQTKPSQARASHPRAGRR-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9PWH2-1", "uniprot_id": "E9PWH2_MOUSE", "id": "E9PWH2-1", "name": "", "aln": "MATEGASSELIEKKRTKLLSVLQQDPDSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCLSNAFPESASTVGFKHEVPRQE---AEETVGVNRNSEDPLSLGTIIPEIAELS---EEKECLDLRALKFFTYKESGHRELAVSSRENQEGHGTPQVTAPHSVKRVEYEVPASITFLSNGQRYEEPDDSLYLEEGEHQEYLGFPEDVETVLEEEAGKDPQCFVYDNEEEWENEETMGFSSEASSCS--EINFSLEEEE-EKSAEERKRVFQHVLSCLNMDRSRKLLPDSVKQFSTDRGREWTPETPGDLAWNFLMKVQALDSTARDFTLRHKMVDEENKELLLARMEKLGIGDAQTIHPLDVLCACMLCADSSLQREVMSNMYHCCFALPLLLPDAENNKSILMMGAMKDLKQ-HATQSSGGPPRETDASLSLMKMPVISFVRLGHCSFSKSRILNTLLSSSRQKPHTFFLRRDLSVPVLPRQISDGLVEVMWHFPDDAELTVSPHVFQKPVAVANLRGDLESFWVQFGFLVEVSSAVFFLTDCLGEKERALLRFLGDDAIERCYVILSPQAKESEEAQIFQKILKLRPSQLLFWEVEEAGDRRRAMEALQAALQEVMSSP-LKCVSLEDMACLARELGIQVDQDFEVIQDTQVSP-----RTIEGENQQPQSQTKSPSESRTQKPLREPGTQCEDSQNAVIFHQTPVFMPYPAHPWPLPIEAGSNFYHVPLRAPRAISSHFRSQQKAEWFFPFPHQNTSVHSRGQNFAIKYLQPWRFYSRERFTRCSATPQQYHPNGPFGRSQR-QASPVQTHPKSRQMSRTLERSGTVVSRVGHGRSLGSQARRAAGKPQPEKACAQGLQLTKAAGKSIRTLPHIKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPRAGRR-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BX69-1", "uniprot_id": "CARD6_HUMAN", "id": "Q9BX69-1", "name": "Caspase recruitment domain-containing protein 6", "aln": "MATESTPSEIIERERKKLLEILQHDPDSILDTLTSRRLISEEEYETLENVTDLLKKSRKLLILVQKKGEATCQHFLKCLFSTFPQSAAICGLRHEVLKHENTVPPQSMGASSNSEDAFSPGIKQPEAPEITVFFSEKEHLDLETSEFFRDKKTSYRETALSARKNEKEYDTPEVTLSYSVEKVGCEVPATITYIKDGQRYEELDDSLYLGKEEYLGSVDTPEDAEATVEEEVYDDPEHVGYDGEEDFENSETTEFSGEEPSYEGSETSLSLEEEQ-EKSIEERKKVFKDVLLCLNMDRSRKVLPDFVKQFSLDRGCKWTPESPGDLAWNFLMKVQARDVTARDSILSHKVLDEDSKEDLLAGVENLEIRDIQTINPLDVLCATMLCSDSSLQRQVMSNMYQCQFALPLLLPDAENNKSILMLGAMKDIVKKQSTQFSGGPTEDTEKFLTLMKMPVISFVRLGYCSFSKSRILNTLLSPAQLKLHKIFLHQDLPLLVLPRQISDGLVEITWCFPDSDDRKENP-FFQKPVALANLRGNLESFWTQFGFLMEVSSAVFFFTDCLGEKEWDLLMFLGEAAIERCYFVLSSQARESEEAQIFQRILNLKPAQLLFWERGDAGDRRKNMEGLQAALQEVMFSSCLRCVSVEDMAALARELGIQVDEDFENTQRIQVSSGENMAGTAEGEGQQRHSQLKSSSKSQALMPIQEPGTQCELSQNLQNLYGTPVFRPVLENSWLFPTRIGGNFNHVSLKASWVMGRPFGSEQRPKWFHPLPFQNAGAQGRGKSFGIQSFHPQIFYSGERFMKFSRVARGCHSNGTFGRLPRPICQHVQACPERPQMMGTLERSRAVASKIGHSYSLDSQPARAVGKPWPQQACTRVTELTEATGKLIRTS-HIGKPHPQSFQPAAATQ-KLRPASQQGVQMKTQGGASNPALQIGSHPMCKSSQFKSDQSNPS----TVKHSQPKPFHSVP--------------------------------------------------------------------------------------------------------------------------------------------------------SQPKSSQTKSCQSQPSQTKPSPCKSTQPKPSQPWPPQSKPSQPRPPQPKSSSTNPSQAKAHHSKAGQKRGGKH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*.:.**:**::*.***.:**:************ ****:****** :** **********:***** :* **:** .:**:**: *:::** :: . : : .. . **.:* * ** .*:: .*** .* : :** *::.:** :.: :*:: .: :** . **: * ****:*: :.:****** ****** : * :. *** .:** . .**: . **.**: * .*. *.* .* . : . : : *** ****:**:.** ******.**:**: *:*** *** :***::************** * **** * :: .*:.:* . :*:* * * ***:******* ***:******:******:* **************.:**:*****: : ::* **** .:*: * * *********** ********:*****.:: * : :**::**.: ************: * ** . . .* ******:*****:***** *****:****.:**:******** ** ***: :*****.:**.**:*********:**:*:*:****** :*****: **.********* *. *:***:*:**.**********:*** * ***. * ***.** ** **.::* : *::***:**: *** :: ***: * :.* :* . *.** **.*.*. .:. * *:*:.:**.*:*.**:..:.**:.*.*: ::* ** ** . * .: : **.*** * . *: * * :** :..*::** * .**. :*.*** .::* :: :**:*:** *** ** ****. ***.* * :: *.*:* .* .*** .:: *:: **:. . .. .:.* .. ** **:**:.** :: :.*::*..: :.*::****.:*** .. :. .*.** * **.*****.*:****:* *.:**:: ", "identical_positions": 528, "similar_positions": 274, "identity": "44.11%" }, { "cls_id": "homologset.agr.HGNC:16395", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "S4R1M9-1", "uniprot_id": "OSB10_MOUSE", "id": "S4R1M9-1", "name": "Oxysterol-binding protein-related protein 10", "aln": "MERAAQSTDGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQSRYFVLDFEAGLLQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSKEKQLWVTQLRACAKYHMEMSSK---------TTPGSRSRSLTLLPHGTPSSASPCSQRHLS-TGAPG-VVSVTRHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSVRQAAPPSHK--PGASETILGWHGPTSHSTDQLKNGTLGSLPSASANITWAILPNSAEEEHNSQPEPEPDSGPELVLSEEEQSDNEDKGEVEPGAMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTSPHPPISAHEHPMADDPSK-----SYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLDHGEEYVFTLPSAYARSILTVPWVELGGKVNISCAKTGYSATVTFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYSNGETKVIDTTTLPVYPKKLRPLEKQGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEERQRVEERKRETLRTPWRPKYFIPEGDGWVYFNPLWKTH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LWM8-1", "uniprot_id": "F1LWM8_RAT", "id": "F1LWM8-1", "name": "Oxysterol-binding protein", "aln": "MERAAQSADGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGLLQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSREKQLWVTQLRACAKYHMETSSK---------TTPGSRSRSLTLLPHGTPSSASPCSQRHLS-AGAPG-VVSVTRHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLTLLQQSVRQAGPPSHK--PGASESILGWHGPTSQSTDQLKNGTLGSLPSASANITWAILPNSAEEEHSSQPEPEPDSGPELVLSEEEQSDHEDKGEVEPGTVEDQHSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTSPHPPISCHEHPMADDPSK-----SYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLDHGEEYVFTLPSAYARSILTVPWVELGGKVNISCAKTGYSATVTFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYSNGETKVIDTTTLPVYPKKLRPLEKQGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEEKQRTEERKRETLRTPWRPKYFIPEGDGWVYFNPLWKTH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXB5-1", "uniprot_id": "OSB10_HUMAN", "id": "Q9BXB5-1", "name": "Oxysterol-binding protein-related protein 10", "aln": "MERAVQGTDGGG--GSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSK---------SAPSSRSRSLTLLPHGTPNSASPCSQRHLS-VGAPG-VVTITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPSQK--PGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSK-----SYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5T9-1", "uniprot_id": "A0ACD6B5T9_DANRE", "id": "A0ACD6B5T9-1", "name": "Oxysterol-binding protein", "aln": "MEKIVNVSHSGG-----SKGKSADLGNPAQRQ-----------SRSGSY---------SPGSAAVSDTHPS-QSQKRHLEGVLNKYTNLLQGWQNRYFVLDPELGQLQYFINEHSKVQKPRGSLPLIGSSVAPSDEFPFMFTVCAANGDFFKLRASDVREQQIWMTQLQLCARRHSDGNAKGCSSSSSSSTSSTGRTRSFSLHPHPVPQNSFISAQKQSPQHGTPASVISITHHRSPTGGQRACSRNPAGLHQVKEVMSQAEGQQKNLVNSIESLPSRGPLSSLDQDLLLLKATSAATLSCLGECLSLLQHNVCQAAQHITHGHPNTGENNS-WSRPKTASEDQMKNGEL-----MCNNTSARHQPHSPIHRSKERLKDKENSSPESVDSSEEITDTEDNEEEDLGVLDDQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYANFMAHPDVFLAITSGATPEERMIRFVEYYLTAFHEGRKGAVAKKPYNPILGESFHCTWDVPREKVRPLRTTSSSPAPAAAAAHSAQTSSNEGLGSYRLRFVAEQVSHHPPVSGFYCECKERRICVNTHVWTKSKFMGMSIGVSMVGEGVLHLLDHDEQYVFTLPSAFARSILTVPWVELGGKVSISCAKSGYSATVTFHTKPFYGGKVHRVTAEVKHNPSGTIVCKAQGEWNGTLEFTYNSGETKVIDTSKLPVIKKKIRPLDKQGQYESRRLWQQVTTALKAGDIDEATEHKHQLEERQRREGKQRSASSSSWKPKYFIKEGEGWVYHNPLWKTK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P35844-1", "uniprot_id": "KES1_YEAST", "id": "P35844-1", "name": "Oxysterol-binding protein homolog 4", "aln": "------------------------------------------------------------------------------------------------------------------------------MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHP----------------------ELFLEPSFINDDNYKEHCLIDPEVESPE--------------------LARMLAVTKWFISTLKSQYCSRNESLGSE--KKPLNPFLGELFVGKWENKEHP-EFGETVLLSEQVSHHPPVTAFS-----------------------------------------------------------------IFNDKNKVKLQGYNQIKASFTKS------LMLTVKQFGHTMLDIKDESYLVTP-PPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGRGYFSGKKNSFKARIYK---------DSKDSKDKEKALYTISGQWSGSSKIIKANKKEE----------------------SRLFYDAAR------------------------IPAEHLNVKPLEEQHPLES---------RKAWYDVAGAIKLG----------DFNLIAKTKTELEETQRELRKEEEAKGISWQR-RWFKDFDYSVTPEEGALVP--------------------EKDDTFLKLASALNLSTKNAPSG-----TLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .: *. ..: : : **:: .* *. . : :*:: * .: * * .. . :* . * .: .:. :.* . .:: * **..: :*:: * . :** : * :: :. : ...: . :. : . . .. ::: ::* : : :::: . *.: . ::* * : * .: .. :: .:*: .:..*:*.:. : *: . .::: :. * . . : . .. * :: :. . : *.: *:: : .* ::.* :.:. *: . ::... *:::: . :. : .* :::: . * :: *. : ::: *. . : .: * ::.. *: : : : : : ", "identical_positions": 43, "similar_positions": 174, "identity": "5.48%" }, { "cls_id": "homologset.agr.HGNC:16396", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B9EJ86-1", "uniprot_id": "OSBL8_MOUSE", "id": "B9EJ86-1", "name": "Oxysterol-binding protein-related protein 8", "aln": "-----------------------MEAALADGEPDRSSLLGDSKDVLGPS----TVVANSDEPQHLTPGKMSQRQGRDANPTPTRDLPQPSLSPAS----------------------------------------LHSQGFER----------------------GKEDISQNKDDSSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQ--KNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMVREGKEHDLSISSDSTHVTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDLYSDKSDKENDPEHDESDNEVLGKSE-ESDTDTSERQDDSYIDPEPVEPLKETTYMEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRG------EDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLKLG-KEVLATLEGHWDSEVFINDKKTDNSEIFWNPTPDIKQWRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKTQEWVCKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHR-TPMVSVPKMKHKP-------TRQQKKVVKGYSSPE-----PDIQ---------DSSGSEAQSVKPSTRRKKGIDLGDIQSSIESIKQTQEEIKRNIMALRNHLL--------SSTPATDYFLQQ---------KDYFVIFLLILLQVIINFIFK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JXN8-1", "uniprot_id": "A0A0G2JXN8_RAT", "id": "A0A0G2JXN8-1", "name": "Oxysterol-binding protein", "aln": "-MEDLTGVRPQEFEIKLLLRGKIKIIHYSEVAEVQERLLGDSKDVLGPS----TVVANSEEPQHLTPGKMSQRQGKDAYPTPTREL-QPSLSPAS----------------------------------------LHSQGFER----------------------GKEDISQNKDDSSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQ--KNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSGLLKRTMMRDGKEHDLSISSDSTHVTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVLGKSE-ESDTDTSERQDDSYIDPEPVEPLKETTYMEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKRVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRG------EDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLKLG-KEVLATLEGHWDSEVFINDKKTDNSEIFWNPTPDIKQWRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWACKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHR-TPMVSVPKMKHKP-------TRQQKKVAKGYSSPE-----PDVQ---------DSSGSEAQSVKPSTRRKKGIDLGDIQSSIESIKQTQEEIKRNIMALRNHLL--------SSTPATDYFLQQ---------KDYFVIFLLILLQVIINFIFK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BZF1-1", "uniprot_id": "OSBL8_HUMAN", "id": "Q9BZF1-1", "name": "Oxysterol-binding protein-related protein 8", "aln": "-----------------------MEGGLADGEPDRTSLLGDSKDVLGPS----TVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPAS----------------------------------------PHSQGFER----------------------GKEDISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQ--KNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSE-ESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRG------EDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLG-KEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHR-TPMVSVPKMKHKP-------TRQQKKVAKGYSSPE-----PDIQ---------DSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLV--------SSTPATDYFLQQ---------KDYFIIFLLILLQVIINFMFK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4JCZ0-1", "uniprot_id": "A0A0B4JCZ0_DROME", "id": "A0A0B4JCZ0-1", "name": "Oxysterol-binding protein", "aln": "MQQPATPSTPVNNAPSATPSAASGPAASAPAVASSTPIRINSAKQQGAAGGGDTLAHPATPHSHSMPGTPHQQPQSSSVPTGGHLLQLQAPLPSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGISITPPNSAGLRQSTVFDFKFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLR-------------SNSSTGTAPTSSYIGEPLPVSHETQWSEADYEK-HFNDHDLDAD--------SQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVE----TSYVPFTEEEFGEQGE--QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRG------ECYTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLG-KETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSY-GQWLYKYADLRPWDSRNDVRQYECQFKVLTQTRHKSVPIVHGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSDSSQSPQGAVKRSSSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYALIGLAFSLILRWLFK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q02201-1", "uniprot_id": "OSH6_YEAST", "id": "Q02201-1", "name": "Oxysterol-binding protein homolog 6", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSKKLTVGSDSHRLSKSSFSSNKSSHSATKDQPIDTD------------------------------------------------------------------DIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLP-NKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPN--FQADIEFKTKGYVFG--TYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKES-PLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDP-EKQIRSILQIAPILPGQ-----------------------------------------------------------------QFTDKFFIPAFEKIKSQKKMIENEKQNPAKQ-----------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P38755-1", "uniprot_id": "OSH7_YEAST", "id": "P38755-1", "name": "Oxysterol-binding protein homolog 7", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALNKLKNIPSLTNSSHSSINGIASNAANSKPSGADTD------------------------------------------------------------------DIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLP-NKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPK--YQVDIEFKTKGFISG--TYDAIEGTIKDYDGKEYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHF-PLAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEGTDKHEEQIRSILETAPILPGQ-----------------------------------------------------------------TFTEKFSIPAYKKHGIQKN-----------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . : :* : : *..:.:: ::.*::** **:::.******* :*:*::::: ..:.* :* :.: *: *: ***:.:: *:.:*** **:*** * . * * . .:::**:**.***** .*:: :..: : ::.**:* *** :*:::* : : :* * *. : * .: :*** *.: :***. : * : : . :*** * :: . : : *.:* : :.*:*:. :.* : . .. . * :. * **.:**::*: *: .:: **:** :*: ** *:.* . .**. : * . * . * . . : . : . . ", "identical_positions": 96, "similar_positions": 138, "identity": "9.35%" }, { "cls_id": "homologset.agr.HGNC:16397", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CI95-1", "uniprot_id": "OSB11_MOUSE", "id": "Q8CI95-1", "name": "Oxysterol-binding protein-related protein 11", "aln": "MQGGEPASVMKVSESEGKLEGLATAVTPNKNSGNSSCGGAISSSSSNSSRGGSAKGWQYSDHMESVNGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLAS--SGNSPISQRRPSQNAMSFFNVGHSKLQS--VNKRAHLHPDHLVEVREMMSHAEGQQRDLIRRIECLPASGLLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGALPSGTTIEWLEPKIPLSNHYKNGAEQP-FATEPNKPMGAPEAQCVAESGVLAREPEDISADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIGITNGATPEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASGVSSSSSTPAITDHAPLPEEAPTQSVSDCYTVRFVAEQVSHHPPVSGFYAECAERKMCVNAHVWTKSKFLGMSIGVTMVGEGVLCLLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKYNLTNTVVCRVQGEWNSVLEFTYSNGETKFVDLAKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKRSLEERQRTEERLRTETGTPWKTKYFIKEGDGWVYHKPLWK-------GIPS-QPAE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BXB4-1", "uniprot_id": "OSB11_HUMAN", "id": "Q9BXB4-1", "name": "Oxysterol-binding protein-related protein 11", "aln": "MQGGEPVSTMKVSESEGKLEGQATAVTPNKNS---SCGGGISSSSS--SRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLAS--SSNSPISQRRPSQNAISFFNVGHSKLQS--LSKRTNLPPDHLVEVREMMSHAEGQQRDLIRRIECLPTSGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKISLSNHYKNGADQP-FATDQSKPVAVPEEQPVAESGLLAREPEEINADDEIEDTCDHKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSDCYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKHNITNTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKHTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWK-------IIPTTQPAE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7UVT3-1", "uniprot_id": "A0A8N7UVT3_DANRE", "id": "A0A8N7UVT3-1", "name": "Oxysterol-binding protein", "aln": "------------MQTEAVLEHHS------------------GSQSS--GRTG-SKSWQYSDLMEKVDGYLMKYTNLVTGWQYRYFVLNNEAGLLEYFVNEQSRNQKPRGSLPLGGAVISPSDEDSHTFTVNAISGEQYKLRASDAKERQHWVSRLQVCAQHHTEAMGKTNPPLQSRSLSMASQGSGSSPGSQHRISQNSNALLGLSQLQRGSSLYSSRKSLLPDHLLEAREMMTQAQGQHRDLIQSIEGLPSSQGPSPLDQDLLLLKATSLATMTCLSDCLHILQLQQVARQKFPL-SGPALEWLEPKLP--DILKNGGTLPSITKDDGKTEGAVLEPLEMDSCDIVLEQEEIDATQEVDDSSPSEEEDLGAVEEERSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFVAITDGSSPMDRMVRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWNVPK--------EAASPTGIPKEG-------SSCASDCYNVRFVAEQVSHHPPVSGFYAECQERQMCVNTHVWTKSKFMGMSIGVSMIGEGNLNLLEHGEEYTFSLPSAYARSILTVPWVELGGKVNVNCAKTGYSAVITFQTKPFYGGKLHRVNAEVKHNPTNAVVCRVQGEWNGVLEFAYTSGETRFVDVTKLPVTRKRVRPNELQGPYESRRLWQHVTESLKERDMDKATEHKRFLEERQRKEERHRAETQTPWRTKYFERKGEGWMYYQPLWKTAGQSSSSVPSPQNP-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P35844-1", "uniprot_id": "KES1_YEAST", "id": "P35844-1", "name": "Oxysterol-binding protein homolog 4", "aln": "-----------------------------------------------------MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPIS------LTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTK---WFISTLKSQYCSRNESLGSEKKPLN---------------------------------------------PFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVKQFGHT-----------------------------------------------------------MLDIKDES----------------------YLVTPPPLHIEGILVASPFVELEGKSYIQSSTG--------------------LLCVIEFSGRGYFSGKK--------------------------------------------------------NSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLES---------RKAWYDVAGAIKLG----------DFNLIAKTKTELEETQRELRKEEEAKGISWQR-RWFKDFDYSVTPEEGALVPEKDDTFLKLAS-------------------------ALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL---------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : *. .. : .:.. ::. . *:*. : :.* *: : * * :.*. .: ..* : .. : : :* ::* *: :.*::*. : **: : : :: * :.: . *: .. .: :* :* . :.. :* ::: .: :. :* :*:: * :: *. * . ** :* :: :. :: .:*: .:..*:* :.:..*: :. . : ..:*: . : . . : .*.: : ..: : * : *::.:. .* ::.* :.:. *: . :*... *:: : :. : .* :::: : * * . .. : :: :*:: .*:* . : *: : . : : ", "identical_positions": 49, "similar_positions": 171, "identity": "6.41%" }, { "cls_id": "homologset.agr.HGNC:16398", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K4M9-1", "uniprot_id": "OSBL1_RAT", "id": "Q8K4M9-1", "name": "Oxysterol-binding protein-related protein 1", "aln": "-MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHGTEMKHILVGN--KVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVP-KNSLQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVP-------ANSGKHRMSEGKDCGGGD-----ALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKK------------------------------TSKQASTSEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMET--VIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNR-SKSEEDWKTR-------WFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91XL9-1", "uniprot_id": "OSBL1_MOUSE", "id": "Q91XL9-1", "name": "Oxysterol-binding protein-related protein 1", "aln": "-MNTEAEQQLLHHARNGNAEEVRKLLAAMARMEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVEDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVLLLLEYDADSTVVNGSGQTAKEATHDKEIRNMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAQGAEMKHILVGN--KVVHKALKRYEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDSCLFSIRCFDDTVHCFRVP-KNSVQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVVSAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADIVSEASRETCVALNDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEEEFYDALSGSESEGSLTCLEAVTAHSFEENEVP-------GSSGKHRMSEGKDCGGGD-----ALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKK------------------------------NSKQTSSSEESDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMES--VIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAARKNR-SKSEEDWKTR-------WFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BXW6-1", "uniprot_id": "OSBL1_HUMAN", "id": "Q9BXW6-1", "name": "Oxysterol-binding protein-related protein 1", "aln": "-MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGN--KVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVP-KNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEH-------LGSRKHRMSEEKDCGGGD-----ALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKK------------------------------NSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMES--VIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNR-SKSEEDWKTR-------WFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q392-1", "uniprot_id": "A0A8M9Q392_DANRE", "id": "A0A8M9Q392-1", "name": "Oxysterol-binding protein", "aln": "MEELDPEEQFLRDARNGNLEGIQRLLMCKIKEEANIDINCKGKSKSNHGWTPLHLACYFGHRDVVEALLKAGADANLPNNVGDTPLHKAAFTGRKEVVMLLLQHDACASVINGMAQIPKDITQSAEIKSMLEATERTEERKLEEQLLEAAREGAVSTLTRLLNLKKPPNINCTDLLGNTPLHCAAYRGQKQCAVKLLQHKANPNVKNKNDQTVFDLTNDAEMKQIIAGNVVKGMTRHVKMFEGPLWKSSRFFGWRSYWVVLQDGVLSWYPKQTDADSNTRRQGCKPLTQAHCMIKAKDNCYFTVKCFDDSVHHFKVTQKNNPEESRKMWLEAIEEHSAFSTHYCSQEPDSEEEEDNAVSVNELSESLQRAESCHQRLEKEVLSLLSMVKEDGLAEKIPVTVIQKLKDVCEASSESCSSLHRCLELFSRQEGARSVKLEQEVEKNKILSEALQTLATEHHELEQSVVKGSSPRSVLSDDEFYDALSDSDSEPVLSGFQTDGHSHEDHDDFTSELYCSIPGQHSGRMSQEERRGEEEDDEEVANVNGLRKHRTSLPAPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHQANSSENSIERMKCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLDFRLISEQVSHHPPISAFHAEGLQKNFVFHGSIYPKLKFWGKSVEAEPKGIITLELPKHNEAYTWTNPTCCVHNIIVGQLWIEQYGNVEVINHRTGEKCCLNFKPCGLFGKELHKVEGYILDKSKKKVCVLYGKWTECMYLVDPATFETHKKNDKKASEEKK------------------------------SSKQSQSSD-SEETPQPGGDSLEVIPGSQLLWRIAPRPANSAQMYSFTSFALQLNELDKEIES--VIPKTDSRLRPDIRAMENGDIDMASEEKKRLEEKQRAARKNR-SKSDDEWKARNIASGPRWFHQGPNPHNGSQDWLFSNSYWDRDYSQVPDIY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4LGH8-1", "uniprot_id": "A0A0B4LGH8_DROME", "id": "A0A0B4LGH8-1", "name": "Oxysterol-binding protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEG--------------DYAEHVERTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPPVSAFHAE--SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKMEITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIPDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLEEGNLDGASKEKTRLEEKQRHTRKQRKSTNSDDWSPR-------WFKYATNPHTKIDDWLYSGGYWDRKYDNTDTIF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:: . : .**.**:.*:**::.***:**::*** :********::********** ****:: *: :* . ... :**: ********:**:*** ************** :.* :*::.********:****** .::* ***:* **:********.:*** :*:*: . **:*:*** .*********:*******::*: ** **. . *.**..* .*:**:***:: * *:.:: ******* : .. :: . *:..: .:: . .*.. . : : * ... **.* ** ***.*.:: *.** **: ** :*.:::. .: **.****** :*:*::* **:**.******* :**:* *...::*..* **: ..**:. :**::*..****.* : *:", "identical_positions": 212, "similar_positions": 136, "identity": "21.07%" }, { "cls_id": "homologset.agr.HGNC:164", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ARF4-1", "uniprot_id": "A0A8I6ARF4_RAT", "id": "A0A8I6ARF4-1", "name": "F-actin cross-linking protein", "aln": "MSSVCCVLVLRPRLCAQACSPRNREKVTTARRLSIHPSIHPSIHPSIHPSIHFSIRLSIPRAALAPQSPQPPSAMNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLG-----EAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JI91-1", "uniprot_id": "ACTN2_MOUSE", "id": "Q9JI91-1", "name": "Alpha-actinin-2", "aln": "--------------------------------------------------------------------------MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLG-----EAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P35609-1", "uniprot_id": "ACTN2_HUMAN", "id": "P35609-1", "name": "Alpha-actinin-2", "aln": "--------------------------------------------------------------------------MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLG-----EAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N882-1", "uniprot_id": "A0A8M1N882_DANRE", "id": "A0A8M1N882-1", "name": "", "aln": "-------------------------------------------------------------------------MMNQIELSVPYDNGYEIDEYMMQEDEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDFITSKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHVSWKDGLALCALIHRHRPDLIDYAKLNKDDPLGNLNLAFDIAEKHLDIPKMLDAEDILSTPKPDERAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLGVNQENEKLMEDYERLASELLEWIRRTIPWLENRAAEKTMVEMQRKLEDFRDYRRMHKPPKVQEKCQLEISFNTLQTKLRISNRPAFMPSEGKMVSDIASAWQGLEQAEKGYEEWLLTEIRRLERVEHLAEKFRQKATNHESWATGKEEMLTRKDYESASLMEVRALLRKHEAFESDLSAHQDRVEQIAAIAQELNELDYHDVASVNQRCQSICDLWDHLGTLTQKRREALERTEKLLETVDQLFLEYAKRSAPFNNWMEGAMEDLQDMFIVHTIEEVQTLIAAHEQFKATLPEADAERQAILGIQQEVLKIFQSYGIRGDLTNPYSTITAEEIAIKWDKVKKLVPQRDSALQEELARQHANERLRRQFAAQANLIGPWIQTRMEEIGHCSMAMGGTLEDQMTQLKQYEHVIVSYKSNIDRLEGDHQLIQESLIFDNKHTNYTMEHVRVGWELLLTTIARTINEIETQILTRDAKGISQEQMHEFRSSFNHFDRKKNGGMDSDDFRACLISMGYDLG-----EVEFARIMMLVDPNASGNVSFQSFIDFMTRETADTDTAEQVIASFKILAADKPYILSDELRRELPPDQAEYCISRMPPYCGPGALPGALDYTAFSTALYGESDL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P18091-3", "uniprot_id": "ACTN_DROME", "id": "P18091-3", "name": "Alpha-actinin, sarcomeric", "aln": "-------------------------------------------------------------------------MMMENGLSMEYG-----DGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : .: *. * ** **:**:*: **********:**************** *:********************** **********************:*:****:*************:*********************** :****************:***:**** *:****.:**************:**.**:*: *:* *:::***:****:***.:*::.***************:**** **:*. *********** ******:***:******:********:***:.* .:::: :*:***::* *** ****:*::*.:** .*********:*****::*:*** ****:.:*: ** ***.:***** * ****:****:**::** ** *: ***::* :*:....* *::** :*********:***************** *:*** ..** *** *** **:**:***:** **:. *::**.:* *.**:***:******::*: *** ******::**:* ** **:****** *** * : *: : .** .:.:.: * . ***:*:* ::: **..*::*** **.:* :** :*: ** ****** :** :****: :*: : .: : *:****: :**:**: : ** **:.** ** :**:::*:*::****** :***** ***:* *.***:*.******:***:***::***:******:.:.* :. ::*::**:*:**.:* : :* **: :**** * * *::*:******::********* **:***:******.:***********:***.***.* **..:****** :**:*****:**", "identical_positions": 587, "similar_positions": 202, "identity": "58.99%" }, { "cls_id": "homologset.agr.HGNC:16400", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M9PLT8-1", "uniprot_id": "A0A8M9PLT8_DANRE", "id": "A0A8M9PLT8-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSMNHPKHFKSGETQNDLGSAHQKRSD-PEPSCVSMKSDWSMN-------------------------------------HPIKFKSGDTKN-------DLSSVQK----------------------------RSDPEPSCVSMKSDWSMDPPMQFKSKDTPPDLSSVHQERSE-PEPSCMSMNS-DLPLDPPIR--------------------------------------------------YKSGET-----------------------QNDLS------------PQVFNTFRSNLLKKFECLYEGTAAQGNPTLLNEIYTELYITESKSGEISHEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLMKD-KTLSLSDLLQLFFPQTKEMEISSDK--YKVLFIFDGLDECRLSLDFQSAVRLCDVSESASVDELLTNLIVGNLLPSALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPVFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHFLILQTNIKHQKDYEEKLT--------DEDMILKLGKVAFQQLMKGNIIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFVHLSIQEHLAALYVHLSCINKSINQFNFAAKQ-------------------------SLWSKT--KFMFKT---VALSELHQRAVVETLQSKNGHLDLFLRFLLGLSVESHQILLQRPLKLKRRSIKNN-KTVEYIKKKIRTID--SPEKSINLFHCLNELGDHSLVEEIQQYLKSGGINEAKLSSSQWSAVAFVLLTSEKKLEEFNINEFVAE-------NNKTEKLVIFKKLLP-VIRECRSVQLYNCGLTGEGCAALASALISNPEHLTDLNLSRNNLGDSVTLLSAV-LEDPHCKLEKLWLSYCGVT----------------------------------------------------------DEGCAALVSALRSNPEHLRELNLSGNNL-GDSVTLLSAVLEDPHCKLEKLRLYYCGLTDEGCAALASALRSNPEHLRDLDLSWNKLGDS-VTLLSAVLEDPRCKLEKLE-------------------------------------------------------------------LYNCGLTDEGCAALASALRSNPEHLRDLNLSGN----------------------------------------------------------KLGDS-VTLLSAVLEDPRCKLEKLWLSDCGLTDEGCAALASALRSN------------------------------------------------------------------------------------------------------------------------PEHLTELDLSWNNLSKSTVRLFSDLKDNPHNKLKTLHI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PCI8-1", "uniprot_id": "A0A8M9PCI8_DANRE", "id": "A0A8M9PCI8-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDTQTTIEKDYSPR-----------------------FSLVHQKRSEPSCVSIRRDQSVAHPIDFKSEDTQTHLSSVHQERLD-PEPSCVSIRSDRSVA-------------------------------------HPIDFKSKNTH---------LSSVHQE---------------------------RSEPEPSCVSIRSDRSVAHPIDFKSEDTQTHLSTFHQKRKE-ADPSCVSMRS-DTFMNQPIN--------------------------------------------------IKIGET-----------------------QNDLK------------QNLLNTFRSNLLKKFECLYEGTAVQGNPTLLNEIYTELYITESESGEISHEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQNK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLMKD-KTLSLSDLLQLFFPQTKEMEISSEK--YKVLFIFDGLDECRLSLDFQSAVRLCDVSESASVDVLLTNLIVGNLLPSALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPVFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHFLILQTNIKHQKDYEEKLT--------DEDMILKLGKVAFQQLMKGNIIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFVHLSIQEHLAALYVHLSCLNNNRNEFEQISKQ-------------------------SLWSKVRDHFHFNSSKLVSISKLHQRAVNEALQSKNGHLDLFLRFLLGLSVESHQILLQGLMKLKIRSIQNN-ETVEYIKKKIRKIN--FPEKFINLFHCLNELGDHSLVEEIQQFLKSGGMNEAKLSSSQWSAVVFVLLTSEKKLEKFDINEFAAR-------NNNTEQLFIFKKLQP-VIRQCRSVQLSYCGLTDEGCAALASALRSNPEHLRDLYLSGNKLGDSVSLLSGV-LEDPHCKLETLWLSDCGLTSKDSAALASALRSNPEHLRVLDLSWNRLGDS-VTLLSAVLEDPHCKLETLLLRDCGLTDEGCAALASALRSNPEHLKHLDLSWSNL-GDSVTLLSAVLEDPRCKLEKLGLSNCGLAEEGCAALASALRSNPEHLRGLNLSVNNLGDS-VTLLSAVLEDPRCKLEKIK-------------------------------------------------------------------LSYCGLTDEGCAALASALRSNPEHLRDLDLSTN----------------------------------------------------------NLGDS-VTLLSAILEDPHCKLEKLELKNCGLTDEGCAVLASALRSN------------------------------------------------------------------------------------------------------------------------PEHLRDLNLSWNNLSNSTKKLLSDLKDDPHNKLETLHTSLSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TA29-1", "uniprot_id": "A0AB32TA29_DANRE", "id": "A0AB32TA29-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDTKISKDEDYSPRFSSVHQERSD-LEPSCVSMRSEQSMG-------------------------------------SPMHFRSEDTEA-------DLSSVYQK---------------------------RSDPEPSCVSMRSDWSMDLPYNFRSEDTPTDLSSFHHKRTE-AEFSRVSMRS-DMFINHPIN--------------------------------------------------IKNVEA-----------------------QCNIR------------QNLLNTFRSNLLKKFECLYEGTAAQGNPTLLNEIYTELYITESESGEISHEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLMKD-KTLSLSDLLQLFFPQTKEMEISSDK--YKVLFIFDGLDECRLSLDFESAVRLCDISESASVDVLLTNLIVGNLLPSALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPMFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHFLILQTNIKHQKDYEEKLT--------DEDMILKLGKVAFQQLMKGNIIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFVHLSIQEHLAALYVHLSCINNNRDEFEQIKKQ-------------------------SLWFKVKDLFQLNSLECVSLFSLHQRAVNEALQSKNGHLDLFLRFLLGLSVESHQILLQRLMKLKSRSMQTN-KTVKYIKMKIWTID--SPEKSINLFHCLNELGDHSLVKEIQQYLKSGRINRAKLSSSQWSAVAFVLLTSEKKLEEFNINEFVAG-------NNENKKQKVFQKLLP-VIKQSRSVLLYNCGLTEMDWDNLTSALRSNPSDLRVLNLSRNILGNSVTLLSAV-LEDPCSKLEKLWLSDCGLTDEGCAALATALRSNPEHLRELNLSWNNLRDS-VTLLSAVLEDPRCKLETLWLSKCGITGKSCAVLASALRSNPEHLRDLDLSGNKL-GDSVTLLSAVLEDPHCKLKILWLSDCGLTDEGCAALASALRSNPGQLRVLDLSENKLKNSGVMQLCAVLEDPHCKLDKLG-------------------------------------------------------------------LYDCSLTDEGCVALASALRSNPEHLRELDLSVN----------------------------------------------------------KLRDSGIKLLSAVLEDPRCKLEKLWLSNCGLTDEACAALASALRSN------------------------------------------------------------------------------------------------------------------------PEHLRELNLSKNKLGESDVKLLSDLKDDTHYKLKELNY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3AQ59-1", "uniprot_id": "A0A8M3AQ59_DANRE", "id": "A0A8M3AQ59-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKIFQN--------LTAESGKG-IRDYVVQIRFCFIMD-------------------------------------DTQISRDENVSP-------GCSSVHQK---------------------------RSDPEPSCVSMRSDWSMDPPISFKSKDTPPDFSSVHQKSTE-SEPSCVSMRSDDESVDQPLH--------------------------------------------------VRSGDT-----------------------ETDLS------------HEALNTFRSDLLKKFECLYEGTAAQGNPTLLNEIYTELYITESESGEISHEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIIPLPFREINLMKD-KTLSLSDLLQLFFPQTKEMEISSDK--YKVLFIFDGLDECRLSLDFQSAVRLCDVSESASVDVLLMNLIVGNLLPSALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPVFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHLLILQTNIKHQKDYEEKLT--------DEDMILKLGKVAFQQLMKGNIIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFVHLSIQEHLAALYVHLSCINNNRDGFEEIKKP-------------------------SLWSKVKDLLYLNSSQLVSLSELHQRAVNEALQSKNGHLDLFLRFLLGLSVESHQIILQRLMILKSRSIQIN-KTVEYIKMKIRTID--SPEKFINLFHCLNELGDHSLVEEIQQYLKSGRINRAKLSESQWSAVAFVLLTSEKKLEEFHINEFVG----------ETEKIFIFMKLLP-VIRECRSVQLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCGLTDEGCAALASALRSNPEHLRELNLSGN----------------------------------------------------------RLGDS-VTLLSALLEDPRCNLEILWLSYCGLTDEGCAALASALRLN------------------------------------------------------------------------------------------------------------------------PEHLRELNLSHNNISKSTVKLLSDLKHNPHNKLETLYI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7FA88-1", "uniprot_id": "E7FA88_DANRE", "id": "E7FA88-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYCNYNMDNTRSSRDE-----------------------DIYSCTSRESEEVLSNTSYWSL--PSYFRHR--KFHRSSVHEKISDSSESSRVSLKSDWSMN-------------------------------------PPPLLGEER----------KSSNLNMS---------------------------------SLVSVRSDWSMDPPPLLR-------------AKGKSAVSSGVSDNI-DWLVCSPYL--------------------------------------------------RVERKS------------------------SALR------------------HKLSLLKKFQCLYEGTAVQGKPTLLNEIYTELYITESESGEISHEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLIKD-KKFSLVSLLQTFFTREIHLDMIQN---SAVIFIFDGLDECRLPFNFSRNEILLDVTKETSVDVLLTNLIVGNLLPYALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPVFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHFLILQTNIKHQKDYEEKLT--------DEDMILRLGKLAFQQLMKGNIIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFVHLSIQEHLAALYVHLLFTNHNINVFEQMTKSFEGTPLNKSDLQSLTLNMELFEISEPVLTDVAAMCEMDWRVVNEISALHCKAVDEVLQNKNGHLDLFLRFLLGLSVECNQILLQRLTKQRRHLYNDN-KTVEYIKKKIRTIN--SPEKSISLFHCLNELGDHSLVEEIQQYLTSGKIKEFKLSSSQWSAVAFVLLTSEKKLEEFWLKEFVGA-------ETKADH--VLQKLLP-VVKESRKAELSKCGLTEECCAALASALRSKLSHVRELDLSGNKLGDS--------------------------------------------------------------------------------------------------------------------GIENLSTGLENLHCKLEILRLRSCGITAKGCTALASALRSNPEQIRQLDLSENNIRDWGVKHLFTELKNPDCKLEILG-------------------------------------------------------------------LRNCGITIEGCAALTSALIINPSHLRELDISRN----------------------------------------------------------SLGDTGQELLTSLLNSQHHKLEILLLHKFPMT------FTSLPSSH------------------------------------------------------------------------------------------------------------------------SPEMFPQRFRTHNLKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6YSM0-1", "uniprot_id": "A0A8M6YSM0_DANRE", "id": "A0A8M6YSM0-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSHKQTLKYFSPVCSS-----------------------VQQERSDSAEPSSVSVKSHWSIDPPPQMTER--RDSLSLALQERSDSPEPSHVSMKSDWSID-------------------------------------PPPQMKEENRSLVQQERSPKSSCVSMKRDWSIDPPPQMNDEDGQKRLSLVQQERSDSAEPSLVSMKSDWSIDPPPQMKDGDRQKSLSLVQQERSDSPEPSHVTMKS-NWSIDPPPQ--------------------------------------------------MTDRRDSLRQIPRPRPGAEEPISKKMKYDESVIKSQECMENPSLIFSHEVNTFRVNLLKKFQCLYEGMVTQDNPALLNEIYTELYITESESGEISNEHEVRQIETQSRRSTTEDTAIKCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLMKD-KTLSLSDLLQLFFPETKEIDIFSDK--YKILFIFDGLDECRLLLNFKSNEILQHVTKTSSVDVLLTNLIVGNLLPSALIWITSRPAAADLVPSECVH-RVTEVRGFNDPQKEEYFSKRISDQSLANTIISHLKSSRSLYIMCHIPVFCWISATVLEKMLS----------------EAETAE----IPKTLTQMYTHFLMAQINTKDMKYTGKK----------DKDMIFKLGKLAYEQLERGNVIFYEEDLRECGIDVAEASVYSGLCTQIFREEFGLYQGKVFSFIHLSVQEHLAALYVHLLFTNHNRNVFEQMTKKTSKT------------------------LDILDCFHSNSPENVLLSELHQKAVDEALQSKNGHLDLFLRFLLGLSLESNQILLQELMIKFRSSSDSSEKTVEYIKKRINNIC--LPEKSINLFYCLNELGDHSLVKEIQQYMDYGTLAETKISCGQWSALVFILLTVEQAMDVFELNKFIGL-------KKSSDE--VLRKLLP-VIKKSRSAIMDDCNITAEGCAYLASALGSNPSYLRELDLSANKLQDS--------------------------------------------------------------------------------------------------------------------GIKKLSKGLQDSHCKLEKLNLYHCGVTNEGCAALASALKSNPEHLRDLNLSENKIGNLGLTCLSEILKNSLCKLEILR-------------------------------------------------------------------LCQCGIT--DCTDLASALISNPEHLRELELSLN----------------------------------------------------------KIGDSGVTALCAAFEDPRFKLEKLGLSGCGLTDEGCAALTSALRSN------------------------------------------------------------------------------------------------------------------------HEHLRDLDLSGNKVDKEVKGSILQRILEKLNNIQILSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58HZJ9-1", "uniprot_id": "A0AC58HZJ9_DANRE", "id": "A0AC58HZJ9-1", "name": "", "aln": "MVDKEASNDGDFSSRRSHFQSQKSNTSESNPEITPEDLSAKKLIKMFEKRTPDNQSKFNNQKSNTAKSIRSDRSIQNPVKIKEIRTPADLSSQRSNPPESSSVSMKSDQSTLEPEKVDGGHTSTGISSQRSNPPKPMPRSIKSDQSTPELDKVDGGHTSTALSSQRSNPPDPKPRSIKSDQSTPEPDKVDGGHTSTGLSSQRSNPPESSSVSMKSDQSTLEPDKVDGGHTSTGLSSQRSNPPESSSVSMKSDQSTLEPEKVDGGHTSTGIGCQRSNPPDPKPRSIKSDQSTLEPDKVDGGHTSTGLSSQRSNPPESSSVSMKSDQSTLEPDKVDG--GHTSTGISSQRSNP-PESSSVSMKSDQSTL-------------------------------------EPEKVDGGHTST-------GISSQRSNP-----------------------------PESSLVSLKSDQSTLEPDKVDGGHTSTGISSQ---RSNPPESSSVSMKS-DQSMPEPIKFDGGHTPTGLSETSTNDQFMNKQVKIKRRHTLTGLSKTSINYQFMEKQLKTERRHT-----------------------STGLS---------LNSKLFENLLKSNLLKKFQCVSEGTSILGNPTLLNEIYTELYITESDSGEINNEHELRQIETQSRRSAKEDTPIQCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFIVDWAEKNKNQD-IQLIFPLPFREINLMKD-RTLSLSDLLQVFFPETKEMEISSEH--YKVLFIFDGLDECRVSLDFDSGVKLHDVSESASVDVLLMNLIMGNLLPSALIWITSRPAAADLIPSGFVH-RVTEVRGFNDPQKEEYFRKRIRDQSLADTIISHLKSSRSLHIMCHIPVFCWISATVLEKIFS----------------QAERGE----IPKTLTQMYTHFLIMQTNIRHEKDYEEE----------DKDMILKLGKLAFEQLQKGNLIFYEEDLRECGLDLTEAAVYSGLCTQIFREEFGFSQSKVFCFVHLSIQEHLAALYAHHFLTNNCLN--------------------------------------------KHWKTFNPLSFLHQRAVNEALQSKNGHLDLFLRFLLGLSLEFNQTLLQELLTQTGSCSYNTEETVQFIKQKIREIN--SPERSINLFHCLNELGDQSLMKEIQNYLRSGEIKETKLSSSQWSALVYVLLTSEQEMEDFDLNQFIG---------TQNTADEVLQKLQP-VVKESRSVQLSGCSVTDKGCAALALVLRSDSSHLRELDLSENNLRDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKDPHCKLEKLRLSDCGVTDEGCAALASALRSNSTHLTELDLSLNNLEDSGVKLLSDGLKDPHCKLEILR-------------------------------------------------------------------LSDCGVTVEGCADLASALRSNSTHLRELDLTLN----------------------------------------------------------NLEDSGVNLLSAGLKDPHCKLEKLRLSDCGFTDEGCADLASALRSN------------------------------------------------------------------------------------------------------------------------STHLTELDLSLNNFGDSGVKLLSDGLKDPHCKLEKLRLSYCRVRAEGGVALASALRSNPEHLRELDLSENKL-----------------------------------------------------------------------------GNSGVKMLSELKNDSRYKLDTLK-------------F--------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6YU37-1", "uniprot_id": "A0A8M6YU37_DANRE", "id": "A0A8M6YU37-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDNQ------------TFSDAPVCSNESNPEFEPSCVSMKSDQSMD-------------------------------------PPMKFKEGHTSA-------DLS-DRLNP-----------------------------PGSSCVSMKSDWSMDRPIQFKEEHSSADLSN----KSNPGEPSCVSSKS-DQSMGPPIN--------------------------------------------------VMEEHS-----------------------AADLR---------LDPHLKQNGLRSNLLRKFQCLYEGTAMQGDPTLLNEIYTELYITESDSGEINNKHELRQIETRSRRSATEDTPIQCRDIFTPLPGQDK---------AIRTVLTKGVAGIGKTVSVQKFIVDWAEEKENQD-IQLIFPLPFREINLMKD-RTLSLSDLLQVFFPETKEMEISSEQ--FKVLFIFDGLDECRVSLDFKCDVKLHDVSESASVDVLLTNLIMGNLLPSALIWITSRPAAADLIPSEFVH-RVTEIRGFNDPQKEEYFRKRIRDQFLADIIIINLKSSRSLHIMCHIPVFCWISATVLEKIFS----------------QAQSGE----IPKTLTQMYTHFLIMQTNIRHEKDYEEEVR--------DEDMILKLGKLAFEQLVKGNLIFYEEDLRECGLDVTEASVYSGLCTQIFREEFGFYQGKVFCFVHLSIQEHLAALYAHHSLTNKNRNVFKQTKPS-------------------------------LLSKVLNQKKHDSLSVLHQRAVKEASQSKNGHLDLFLRFLLGLSLESSGTLLRELLTQTGSCSYNKEETVQYIKQKIRENR--SPERSINLFHCLNELGEDSLMQEIQDYLSSGEIKETKLSSSQWSALVYVLLTSEKKMDFFDLSKFIG---------PQLRADVVLQKLLP-VVKESRSVRLGDCKVTDKVCAALASALRLNSSHLTQLDLIGNKLGDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKDPHCKLKNLMMRDCGVTDEGCAALASALRSNSTHLTELNLNENNLGDAGVKRLSDGLKGPHCKLEILR-------------------------------------------------------------------LWRCGVRDEGCAALASALSSNSTHLKELELSDN----------------------------------------------------------KLGDSGVKLLSDALKDPHCKLEKLRLNGCGVREQGCVSLALALRFNP-----------------------------------------------------------------------------------------------------------------------SSHLTELDLTSNELGKSGVKLLSDLRDDPRYKLRHL---------------------------ACDMFGRII-----------------------------------------------------------------------------VSSGGGRLDELLPTTSTET--------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7UUW9-1", "uniprot_id": "A0A8N7UUW9_DANRE", "id": "A0A8N7UUW9-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDHRGHRDENLPKGRP-----------------------TFPHRSNPPEPSGVSMKSDRS------MHH--PLKFKGNTGFRVKP-PEPSGVSMKSDRSMH-------------------------------------HPLKFKGGID-----------PGFRVNP-----------------------------PEPSGVSMKSDWSMHHPLKFSGGIDP---------MFRPPEPS-VSEKS-GQSVDPTLK---------------------------------------------------FSVHT-----------------------CHGSS---------HRKPLQT--FRSNLLKKFQCVSEGTARNKSPTLLNEIYTELYITEGDSGEINNEHEVRQIETQSRRSTTEDTPIQCRDIFTALPGQHK---------AIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD-VQLIFPLPFREINLMKD-RTLSLADLLHVFFPETKEMEISRDG--YKVLFIFDGLDECRLSLDFNSGVKLCDISESASVEDLLINLIVGNLLPSALIWITSRPAAADLIPSAFVH-RLTEVRGFTDPQKEEYFRKRIRDQRLADEIIQHLKSCRSLFIMCHIPVFCWISATVLEDMMR----------------RTDIGE----IPKTLTEMYTHFLIIQTSIRHEKHYEKKLK--------DEEMILKLGKLAFRQLMKGNLIFYEEDLRECGIDESEASVYSGLCTQIFREELGLFQGKVFCFVHLSIQEHLAALYVLLSFLLYERDELSEN----------------------------------FRSTRPHEFTCHTVFDLHQRAVDKALQSRNGHLDLFLRFLLGLSLKSNQTLLKNVLTQVGNISYSQEETVEYIKIRIKLNP--SPEKSINLFHCLNELGDHSLVNEVQKYVRSGDLSGSRLSSSQWSAVVFILLTSEQ-LDEFNLRRYLTDSEHQTQTQKLQTPDEVLQKLLS-VVEASRSAVLINCGVSDEGCAALASVLRSKSSNLRELNLSENKVGDS--------------------------------------------------------------------------------------------------------------------GVKRLSAGLKDPHCKLEKLRLRCCGVSDEGCAALASVLKSNSSNLRELDLSWNKVGDSGVKLLSAGLKDPHCKLEKLR-------------------------------------------------------------------LCRCGVSDEGCAALVSVLSSNSSNLRELNLTEN----------------------------------------------------------KVGDSGVKLLSAGLKE-NSKLEKLWLFICGVSDEGCAALASILRSN------------------------------------------------------------------------------------------------------------------------SSNLRELDLTGNKVGDSGVKLLSAGLKDPHCKLEKLTLDFCGVSDEGCAALASALRSNSSNLRELNLFNNNL-----------------------------------------------------------------------------GVSGVKLLSDLRDDPHYKLETLH-------------ISWGFIC--------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6Z1F5-1", "uniprot_id": "A0A8M6Z1F5_DANRE", "id": "A0A8M6Z1F5-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METEGPDSPEPSCVSLRSDHSKA-------------------------------------HHVLFKDEDPFEY-------SSGQTGRS----------------------------SPTPSHVSLASNMSINQPLEFKS------------------CSNTLLLKEIQEAIQSVLR------------------------------------------------------------------------------------------------------------IRFQCLHEGLSKHSVLIPLNDIYTELYITEGEGGELNNEHEIRWIETACRRALTEDRPVNLNDIFKPLHGQDR---------PIRTVLTKGVAGIGKTVSVQKFIIDWAEGEANQD-IWFIFPLPFRELNLLKD-QSFSLKGLLQYFMN--IELDISLHE--GKIMFIFDGLDECRLPLDFHNNVKLCDVTESASVDVLLTNIIRGNLLPSSLIWITSRPAAADVVPSKCIH-RVTEVRGFSDPQKEEYIRKKVSDQTLSDRIISHLKSSRSLYIMCHIPVFCWISATVLKKMLS----------------EAESAE----IPNTLTQMYTQFLMLQLRIKNEKAYDKKSS--------DIDIVLKLGELAFQQLEKLNLIFYKEDLREYGIDEQEASVYSG----LFREESGMFQGKVYSFVHLSVQEHLAALYVYLYFVNENINKLNQP-----------------------------------NFLTSILKCVPTVFDVYQTAVKKALQSTSGHLDLFLRFLLGFSLESNQNLLGDLQVQTESSSDSREQIVGFIKEKIKESP--PPEKMINLFHCLNELNDHSLVEEIQDFLQSESRINMKLTASQWSAMVFVLLTSGQKLDVFDLNKYIG---------TYILPDESLQRLQP-VLAASRTAKLCEHNLTKRGYSVLVSVLTSKTSCLRELNLTRSAVNDSGLKLLCSGLENPQCKLETLRLEFCGVSDKGCDFLASALRSNPSHLKALDLSGNTLNFTGLKNLLAEFQKPHCKLQRLCLRLCGLTDVGCDALASVLRSDPSHLTELNLSGNKLGDLGMKLLAGGLQNPHCKLQILRLGDCSITHEGCAALASALRSNPSHLRELDLSGNKLNNAGVQILSGELENPDCNLEILR-------------------------------------------------------------------LENCDVGEEGCAALAEALKSNPLTLKELDLCWN----------------------------------------------------------KLGNSGVQRLCTSLENPNCTLGVLRLTGCNISENGCAALASVLRSN------------------------------------------------------------------------------------------------------------------------PSYLRDLDLSHNDLRSSGVRLLSSALEKPDCKLEILRLEYCKITDDGCAVLASALKSNPSHLRELYLYMNSFN---------------------------------------------------------------------------LTASGRQLLSKIKDDPHYKLQTLH-------------YESHFFC--------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6Z5L8-1", "uniprot_id": "A0A8M6Z5L8_DANRE", "id": "A0A8M6Z5L8-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKDFNENRSRITDAALDLTLFFLR-------------------------------------------------EMKQDQA-----------------------ADTLQG----------ELFFINQLKCSLKKKYQSVFEGIAQQGDSTLLNNIYTDLYITQGASEQVNTDHEIRQIEAASRRHQSLEIQVECKHLFEA-AEQHE---------QIRTVLTKGVAGIGKSVSVQKFVLDWAEGKENQD-ISFIFPLPFREMNLKEK-ERQSLKDLITQFFPETEGLNLTRSTR-FKVLFILDGLDECRLPLNFAGNETCRDVSSAVSLDVLLTNLIKGNLLPSALIWITSRPAAASKIPADCID-RLTEIRGFNDAQKEEYFRKRLTDQNQAREIIDHIKQSKSLFIMCHIPVFCWISATVLQNILK------LKHRAH---AETLQES-----PKTLTQMYTHFLRFQIQQSRRKYDGENTADVS----WDPNLILSLGKLAFQQLERNNVIFYESDLKDCGIDVDKASVYSGMCTQIFKEETGIILGTMYCFLHLSIQEFIAALYQHLILDNDKKQGWFF----------------------------------------IQISKNKGMIDFLKTAVDKALESENGHLDLYLRFLLGLSLQSNRQLLRGLLTQQDDRDQSKGEIIAYIKQKLEGNL--SPERSINLFYCLNELNDQTLLKQIQSHLSRGSLSSADLSPAQWSALVFVLLTSEEELEVFELQKFQRS-------------DECLIRLSA-VIKTSKRALLQGCYLTVRSCESLSSALQSSNCVLRELDLSNNDLQDS--------------------------------------------------------------------------------------------------------------------GVKKLSDGLKSQHCKLETLRLQFCNLTVQCCESLSSALQSSNCVLRELDLSINDLQDSGVKKLSDGLKSQHCKLDTLR-------------------------------------------------------------------LSGCMVTEEGCGFLSSALTSNPSHLRELDLSYN----------------------------------------------------------HPGDSGVKLLSEQLEDPNYTLDKLNLDHGGE---------TRITAGP-----------------RKYVCFLTLDPNTAHTELILSEENR-EVKSVRE-------NQPYPDHPDRFDYYH------------QVLCRESVCGRCYWEIDWSGDGVVCISVS-----YKSIRRKGGGDECVFG-YNAQSWSLRCDSSRFKFW----HNNTHTDLPVEALSSRIGVFVDHSAGILIFYNIYR---------------------------------------------------------------------------DTMSLIHSVQTTFTEPLCAGFRV--------------YYPGSSVKLS-----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6Z047-1", "uniprot_id": "A0A8M6Z047_DANRE", "id": "A0A8M6Z047-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEERVKDS------------------------------LSEKHRVRSGSCVSSSVSLKSDCSKE-DPPKFSEKTPSSAQSVRSGLCVSSFVSLKSDCSKE-------------------------------------DPPKFSEKTPSSAQSDEDELPDSGQETHRNHKS--------------------FTDNLQSIFQNLESKMFRFLKNELEKFKQILQEENRQEFVKDYNENRSRITEAALDLTLFFLR-------------------------------------------------EMKQDHA-----------------------ADTLQD----------ELLFINQLKCSLKKKYQSVFEGIAQQGDSTLLNNIYTDLYITQGASEQVNTEHEIRQIEAVSRRHQSLETQVEFKHLFK--AEQDE---------QIRTVLTKGVAGIGKSVSVQKFVLDWAEGKENQD-ISFIFPLPFREMNLKEK-ERQSLKDLITQLFPETKGLNLTRSTQ-FKVLFILDGLDECRLPPNFAGNEMCCDVSSAVSLDVLLTNLIKGNLLPSALIWITSRPAAASKIPADCID-RLTEIRGFNDAQKEEYFRKRLTDQNQAREIIDHIKQSKSLFIMCHIPVFCWISATVLQNILN------LKHRAH---AETLQES-----PKTLTQMYTHFLRFQIQQSRRKYDGENTADVS----WDPKLILSQGKLAFQQLERNNVIFYESDLNDCGIDVYKASVYSGMCTQIFKKETGIILGTMYCFLHLSIQEFIAALYQHLILDNNKKQ--------------------------------------------AEKSRNESMINLLKTAVDKALESENGHLDLYLRFLLGLSLQSNRQLLRGLLTQQDDRDQSKEGIIAYIKQKLEGNL--SPERSINLFYCLSELNDQTLLKEIQSHLSRGSLSSARLSPAQWSALVFVLLTSEEELEEFELWKFQRS-------------DECLIRLSA-IIKNSKRALLQSCNLTVQSCKSLSSILQSSNCVLRELDLSNNDLQDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKSQHCKLDTLRLATCNLTVQCCESLSSVLQSSNCVLRELDLSNNDLQDSGVKKLSDGLKSEHCKLDTLR-------------------------------------------------------------------LSGCMVTEEGCGFLSSALTSNPSHLRELDLSYN----------------------------------------------------------HPGDSGVKLLSEKWQCPNYTLDTLNLDHVGD---------MRITAGP-----------------RKYVCFLTLDPNTANTQLKLSKENR-KVKHVREDLRIMRKDRRYPYHPDRFDPVF------------QVLCRESVCGRCYWEIDWSGDHGVFISVS-----YKSIRRKRG-DACEFG-CNAQSWSLLCLSSRFTFR----HNNTHTHVPVKPLSRRIGVFVDHSAGTLIFYNIYK---------------------------------------------------------------------------DTMSLIHSVQTTFTEPLCPGFG---------------FYSGSSVKLS-----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TJY6-1", "uniprot_id": "A0AB32TJY6_DANRE", "id": "A0AB32TJY6-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQ------------------------------QIQETRLKGDTRASQTISSPSSSCSM-AEERVKDS-LSEKHSVRSGSCVSSSVSLKSDRSKD-------------------------------------CPPVFSGETPSSAQSVEFESADSGDETHRRHKS--------------------FTDNLQSIFQNLESKMFTFLKNELEKFKKILQE-NRQEIVKEFNENRSRITEAALDLTIFFLR-------------------------------------------------EMKQDQA-----------------------ADTLVG----------ELFFINQLKCSLKKKYQSVFEGIAQQGDSTLLNNIYTDLYITQGASEQVNTEHEIRQIEAASRRHQSLEIQVKCKHLFEA-AEQDE---------QIRTVLTKGVAGIGKSVSVQKFVLDWAEGKENQD-ISFIFPLPFREMNLMEK-ERQSLKDLITQFFPETKGLNLTRSTR-FKVLFILDGLDECRLPLNFAGNETCRDVSSAVSLDVLLTNLIKGNLLPSALIWITSRPAAASKIPADCID-RLTEIRGFNDDQKQEYFRKRLTDQNQAREIIDHIKQSKSLFIMCHIPVFCWISATVLQNILK------LKHRAH---AETLQES-----PKTLTQMYTHFLRFQIQQSRRKYDGENTADVS----WDPKLILSLGKLAFQQLERNNVIFYESDLKDCGIDVYKASVYSGMCTQIFKKETGFVLHTMYCFLHLSIQEFIAALYQHLILDNDKTQ--------------------------------------------AEKSRDESMIDLLKAAVDKALESENGHLDLYLRFLLGLSLQSNRQLLRGLLTQQDDRDQSKEEIIAYIKQKLEANL--SPERSINLFYCLNELNDQSLLKQIQSHLSSGSLSSARLSPAQWSALVFVLLTSEEELEEFELQKFQRS-------------DECLIRLSA-IIKTSKRALLQGCYLTVPSCESLSSVLQSSNCVLRGLDLSNNDLQDS--------------------------------------------------------------------------------------------------------------------GVNLLSDGLKSQHCKLETLRLVMCNLTVESCESLSSVLQSSNFVLRELDLSNNDLQDSGVKLLSDGLKTVNCKLETLR-------------------------------------------------------------------LSGCMVTEEGCGFLSSALTSNPSHLRELDLSYN----------------------------------------------------------HPGDSGVELLFEKLADPNYTLDKLNLDHGGH---------TRITAGP-----------------RKNACFLTLDPNTTYAFLILSEENR-EVKTVREY-------QLYPDHPDRFDGIYP-----------QVLCRESVCGRCYWEIDWSGDDYVDISVS-----YKSIMRKGVDPECVFG-RNAQSWSLCCDSSSFTFW----HNDTDTRLPVKPLSRRIGVFVDHSAGTLIFYNIYR---------------------------------------------------------------------------DTMSLIHSVQTTFTEPLWPGFT---------------VWCQSSVKLC-----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TPE7-1", "uniprot_id": "A0AB32TPE7_DANRE", "id": "A0AB32TPE7-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-AEERVKDS-LSEKYSVRSGS--SSSVSLKSDWSKD-------------------------------------EPPKFSEKSPSSARSVEYELPYSGDKTHRSHKG--------------------FTKDLPRIFQNLESKIIRYLKNELEKFKKILQEENRQDFVKHFNENRSIITEAALDLTLFFLR-------------------------------------------------EMKQDEA-----------------------ADTLEG----------ELFFINQLKCGLKKKYQNVFEGIAQQGDSTLLNNIYTDLYITQGASEQVNTEHEIRQIEAASRRHQSLEIQVECKHLFEA-AEQDE---------QIRTVLTTGVAGIGKSVSVQKFVLDWAEGKENQD-ISFIFPLPFREMNLMEK-ENQSLKDLITQFFPQTKGLNLTRSTR-FKVLFILDGLDECRLPLNFAGNETCRDVSSAVSLDVLLTKLIKGNLLPSALIWITSRPAAANKIPADCID-RLTEIRGFNDAQKEEYFRKRLTDQNQAREIIDHIKQSKSLFIMCHIPVFCWISANVLLNILKENRNTELKHRDN---SETLHES-----PKTLTQMYTHFLRFQIQHSRRKYDGENTADVS----WDPNLILSLGKLAFQQLERNNVIFYDSDLKDCGIDVYKASVYSGMCTQIFWEETGIILGTMYCFLHLSIQEFIAALYQHLFLDSDKKHLSIF----------------------------------------RQKSKNKVMTDLLKTAVDKALESENGHLDLYLRFLLGLSLQSNRQLLRGLLTQQNDRDQSKEEIIAYIKQKLEGNL--SPERSINLFYCLNELNDQTLLKEIQSHLSSGSLSSADLSPAQWSAVAFVLLTSEEELEEFELQKFQRS-------------DECLIRLSA-VIKTSKRALLQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CNLNVRCCESLSSALQSSNCLLRELDLSNNDLQDSGVKLLSDGLKSQHCKLETLR-------------------------------------------------------------------LSGCMVTEEGCGFLSSALTSNPSHLRELDLSYN----------------------------------------------------------HPGDSGVKLLSEQLEDPNYTLDTLNLNHGGE---------KRITAGP-----------------RKYVCFFTLDPNTANTRLILSKKNR-EVKCVREN-------QSYPRHPDRFDDHP------------QVLCRESVCGRCYWEIDWSGGNEVCISVT-----YKSIRRKRG-YECRFG-YNAQSWSLICSSSRFSFT----HNDTHTDLPVKPFSRRIGVFVDHCAGTLIFYNIYR---------------------------------------------------------------------------DTMSLIHSVQTTFTEPLIPGFW---------------VYSGSSVKLLKTEERFTQNPLQDQ---------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PSD3-1", "uniprot_id": "A0A8M9PSD3_DANRE", "id": "A0A8M9PSD3-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEEQGKMS------------------------------LSEKHSVISDSCVSGSVSVKSDCSKDGDLPNFSVEKPMSAKSVISDSCVSGSVSVKSDCSKDGDLPNFSVEKQTSAKSVISDSCVSGSVFVKSDCSKDGDLPNFSEETPSSGKSFEHKTSDSDFQTHRKHKG--------------------FQDGLLGIFQDLENQIMNYLKHELEKFKKILQKENIIDFVKDFNENRCSIKEAALDLTLYFLR-------------------------------------------------EMKQEES-----------------------ADTLED----------ELIFIHQLKCGLQKKYQCVFEGIAQQGDSRLLKNIYTDLYITQGGSEQVNTEHEVRQIEVASRRHEAQELQVECRHLFEA-SEQDK---------QIRTVLTKGVAGIGKSVSVQKFVLDWAEGKENQE-ISFIFPLPFREMNLKEK-ETLSLMELITQFFPETKGLNLTRRNR-FKVLFILDGLDECRLPLNFAGNETCCDVSSPASLDVLLTNLIKGNLLPSALIWITSRPAAASKIPPDCID-RLTEIRGFNDAQKEEYFRKRLTDENQAKEIIDHVKQSKSLFIMCHIPVFCWISATVLQNILQEKRNNDVKHNQADDASKTLQESNTEDTPKTLTQMYTHFLRFQIQQSRRKYNGEYTPDVS----WDKDAILSLGKLAFHHLLNNNLIFYDTDLEACGIDVYKASVYSGMCTQIFKEETGIILGTMYCFVHLTLQEFIAALYAHLILDTNKKSVFDQ----------------------------------------DSKKINESMIDLLKTAVDKALESDNGHLDLFLRFLLGLSLQSNRRILRGLLTPQDQDDQSTEKILQYIKQKFDANL--SPERSINLFYCLNELNEQTLVKEIQTHLSKGSLSSADFSSAHWSALAFVLLTSDEEMEEFELQKFHKS-------------DECLIRLSA-VIKTCKRALLNDCNLTDRSCSALATVLESDTS-LKELNMSNNNLQDS--------------------------------------------------------------------------------------------------------------------GVKLLCTGLKDMKCELEILRLSDCNITEEGYKALASALRSNPSHLLELDLRGNDPGESGVKELDDLLQDPNCTLKTLRFLSPSAEESCQFVNGVVGKNPLLLKTLNLNDFRSTRNHPFIYEIEDTQVNHLAALLQDKHCRVNMLILGGCSFTDDQWESLTSALKLNPSHLRELILMWN----------------------------------------------------------GPGESGVKILSDFLIEPQLKLEKLCLCYCSITEERCEILTSALKSNPSHLRELNLSQNIPGDSGMKNLSDLLMNPQSKLEKLQLCKCSITEEQCVILTS----ALKSNPSHLRDLNLSLNNLGDSGVKTLSDLLMKPHLKMEKLWLCKCSITEEQCVILASALKSNPSHLRELSLSENNLGDSGVKNLSDLLMKPQFKLEKLHLSHCSITEEQCEILTSALKSNPSHLRELDISKNQIRNTGVNLLCDVLNNSDCKLETLRLN----------------------------------------------DCGITDVSSLTQCLTNTKALQFLKVLYLRENHIGDSKQELSDVVRDSNCELSVDEFSLPDFGQIKDIKCCIS---------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58JCK2-1", "uniprot_id": "A0AC58JCK2_DANRE", "id": "A0AC58JCK2-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGYVFVLSSLCPVFILLQFLLEFLLEIKLFRSIMGNTHAAG-------------------------------------DQDLSTECSSVHQKRAEAEPSCVSMKSDASMGVPITFKSENTGPAVSSVHQ-KRAEAELSCVSMKSDASMNPPIEFKSGNTGPAVSVDRDGQTGDLQQDSLQPEHDELQRVKEQH-------------------------------------------------------------------------------------------------------KTSMKNKYERLFEGINHGETQTLLNRIYTQLYIIEGESEGVNEEHEVLQMEKRARTKPSQHTPVYCNDIFKASAGAGHEEQIKKEKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKDNQD-VDFMFVLPFRELNLIRD-HQYSLHRLLLDFHPKLEDLEP-KIYEQCRVVFIFDGLDESRITLNFSDEEKVCAVTEPSSVAVLMRSLLKGDLLPSALIWITSRPAAAHQIPSTYIK-RLTEIQGFTEPQKEEYFRKRISDEHQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE----------------EDVSAE----IPQTLTEMYIHFLLIQINMRKQKYEE---RDPEKLLQSNRGVILKLAEVAFRQLMKGNVMFYEEDLIESGIDVTDASVYSGICTEIFKEESVIHQRKVYSFIHLSFQEFLAAFFVFYCHLTENREPLRVIYDSEYSYN-------------------------QYLQSSS----EKSLYDLLSSAVVKAVWSSNGHLDLFLRFLLGVSLDSNQRLFQDLLTHTEESSENIRRITQYIKDEIKRGKHLSAERSINLFLCLLEVKDQTLAREIQEFVKSDKHSEEELTPAHCSTISYMIEMSEEPLDELDSNKFNTS-------------DVGRRRLIA-AVRNCRRALLQRCELTVQCCESLSSALQSSNCVLRELDLSNNDLQDS--------------------------------------------------------------------------------------------------------------------AVKLLSDGLKSQHCKLETLRLMTCKLTADSCESLSSALQSSNCVLRELDLSNNDLPDSGVKLLSDGLKSQHCKLETLR-------------------------------------------------------------------LQWCKLTVQCCESLSSVLQSSNCVLRELDLSNNDLQDSGVKKLSDGLKSQHCKLETLRLAMCNLTVQCCESLSSALQSSNCVLRELDLSNNDLQDSGVKLLSDGLKTVDCKLETLRLSGCMVTEEGCGFLSSALTSN------------------------------------------------------------------------------------------------------------------------PSHLRELDLSYNHPGDSGVKLLSEQLEDPNYTLDKLNLDHGGHTRITAGPRKYVCFLTLDPNTANTRLILSEENREVKHVRENQPYPDHPDRFDGVY-QVLCRESVCGRCYWEIDWSGDDG-VCISVSYKSIRRKRGG---VECWFGSNAQSWSLSCSS-SNFSFRHNNTRTDLPVKALNRRIGVFVDHSAGTLIFYNIYRDTMSLIHSVQTTFTEPLCPGFRIYPGSSVKLS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TQ28-1", "uniprot_id": "A0AB32TQ28_DANRE", "id": "A0AB32TQ28-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDTHTSG-------------------------------------DLDLFTSCS-----------------------------------------------------------------------------VDGDDQTRDLQQDSLQPEHDELQRAKNQH-------------------------------------------------------------------------------------------------------KTSMKNKYERLFEGINHGETQKFLNRIYTQLYIIEGESEGVNREHDVLQIEKRARTKPSQHTPVYCNDIFKASAGAGHEEKIKKEKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKANQG-VDFMFVLPFRELNLIRD-HQYSLHRLLLDFHPELEDLEP-KIYEQCRVVFIFDGLDESRITLNFSDEEKVCAVTESSSVAVLMWSLLKGDLLPSALIWITARPAAAHQIPSTYIH-RLTEIQGFTEPQKEEYFRKRISDEHQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE----------------EDVSAE----IPQTLTEMYIHFLLIQINMRKQKYEE---RDQEKLLQSNRGVILKLAEVAFRQLMKGNVMFYEEDLIESGIDVTDASVYSGICTEIFKEESVIHQRKVYSFIHLSFQEFLAAFFVFHCYLTDKREPVMLLYESKYSDDEDVSDGNEY-----------EDSDVQFLQSSS----EFSLCHLLSLAIYKAVMSSNGHLDLFLWFLLGVSLESNQRLFQDLLTHTEESSESIRIITQDIKDKIKTDDDLSAERSINLFLCLLEVKDQTLAREIQEFVKSDKHSERELSPAHCSTISYMIEMSEEPLDELDFNKLNTS-------------PVGRWRLIP-AVRNCRRALLQWSYLSVQYCESLFSALKSSNCVLRELDLSTNDLQDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKSPNCKLETLRLQCCNLTAQSCESLTSALQSSNCVLRELDLSNNDLQDSGVKLLSDGLKSPNCKLETLR-------------------------------------------------------------------LVMCNLTVQCCESLSLALQSSNCVLRELDLSNNGLQDSGVKLLSDGLKSQHCKLDTLRLVMCNLTVQSSESLSSALQSSNCVLRELDLSTNDLQDSGVKLLSDGLKSQHCKLETLRLSGCMVTEEGCGFLSSALTSN------------------------------------------------------------------------------------------------------------------------PSHLRELDLSYNHPGDSGVKLLSEQLEDPNYTLDKLNLDHGGHTRITAGLHKYACFLTLDPNTTYAFLILSEENREVKRVREYQQYPDHPDRFDGIYPQVLCRESVCGRCYWEIDWSGDGCSVCTAVSYKSIRRKGRG---AECLFGRNAQSWSLCCSS-SSFIFRHNYTRTELPVKPLSRRIGVFVDHSAGTLIFYNIYRDTMSLIHSVQTTFTEPLYPGFTVWCQSSVKLC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58JCJ8-1", "uniprot_id": "A0AC58JCJ8_DANRE", "id": "A0AC58JCJ8-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEERVKDSLSEKHSVRSGSCVSSSVSLKSDRSKEEHLPNFR-------------------------------------EKTPPSAQS---VRSGSCVSSSVSLKSDWSKRDPPNFREKTPSSAKSSVHQ-KRAEAEPSCVSMKSDWSMNRPITFRSKITQPAISVDRDDQTGHLQQDSLQPEHDELQRVKEQH-------------------------------------------------------------------------------------------------------KTSMKNKYERLFEGINHGETQTLLNRIYTQLYIIEGESEGVNEEHEVLQMEKRARTKPSQHTPVYCNDIFKASAGAGHEEKIKKEKAQIKTVLTKGIAGIGKTVSAQKFILDWAEEKDHQD-VDFMFVLPFRELNLIRD-HQYSLHRLLLDFHPELEDLEP-KIYEQCRVVFIFDGLDESRITLNFSDEEKVCALTESSSVAVLMWSLLKGDLLPSALIWITSRPAAAHQIPSRYIK-RLTEIQGFTEPQKEEYFRKRISDEHQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE----------------EDVSAE----IPQTLTEMYIHFLLIQIHMRKQKYEE---RDPEKLLQSNRGVILKLAEVAFSQLMKGNVMFHEEDLTESGIDVTDASVYSGICTEIFKEESVIHQRKVYSFIHLSFQEFLAAFFVLYCHLTENREPLRVIYDSEYSYN-------------------------QYLQSSS----EKSLYDLLSSAVVKAVWSSNGHLDLFLRFLLGVSLESNQRLFQDLLTHTEESTESIRRITQHIKDKIKRDKRLSAERSINLFLCLLEVKDQTLAREIQEFVKSDKHSEEELSPAHCSTISYMIEMSEEPLDELDFNKLNTS-------------AEGRRRLTA-AVRNCRRALLQGCNLTVQCCESLSSALQSSNCVLRELDLSNNDLQDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKSQHCKLETLRLQWCKPTVQSCESLSSALQSSNCVLRELDLSNNDLQDSGVKKLSDGLKSQHCKLETLR-------------------------------------------------------------------LVMCNLTVQCCESLSSALQSSNYVLRELDLSNNDLQDSGVKKLSDGLKSPNCKLETLRLVMCNLTVQCCESLSSALQSSNCVLRELDLSNNDLQDSGVKLLSDGLK-RNCKLDTLRLSGCMVTEEGCGFLSSALTSN------------------------------------------------------------------------------------------------------------------------PSHLRELDLSYNHPGDSGVKLLSEQLEDPNYTLDKLNLDHGGETRITAGPRKWVCFLTLDPNTAHTQLILSEENREVKRVRENQPYPYHPDRFD-VHRQVLCRESVCGRCYWEIDWSGDVG-VCISVSYKSIRRKGRG---VECWFGYNAQSWSLICSS-SRFSFRHNHTDTDLPVEPLSRRIGVFVDHSAGTLIFYNIYRDTMSLIHSVQTTFTEPLCPGFTVYSGSSVKLS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3B0M3-1", "uniprot_id": "A0A8M3B0M3_DANRE", "id": "A0A8M3B0M3-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESD-EQHNDTLVQMGSSGNSGIN----ADLRAEKEATV-------------------------------------IAPLLNGN-------------------------------------------------------NITGPVTFNYCSNSAENEPQKYPKTADKHTEKQDDLKLQK-------ILETH-------------------------------------------------------------------------------------------------------RTYMKKKVDCILDCT--KENAEHFKAFYTELFIAEGDMQDVNQEHEILKIDDAFKKKKASLRSIRCKDIFAELK----------AKSEKNTVLTKGIAGIGKTVSVRKFILDWAEGQTNHD-IHCVFLLPFREINLMTN-EDFNLHEFLLKFYPELKELETSVLFQQCNLAFIFDGLDESRLPLNFK-SRTLNNVEERSSVDMLFTSLVKGNLLPSALVWVTSRPAAANQIPPRYVG-LFTEVQGFTDQQKEKYFRNRIADETQASKIISHIKTSRSLYIMCHIPVFCWITATVLQDILQ----------------RN-IES----IGTTLTEMYIHFLLIQMNMKSQKYDPEEEREYAKLLEANREVILKLAKLAFEQLKKENVVFYEQDLKDCGIDVN--VEFTGMIAEIFKVEHGLHEAKVFYFVHLSVQEFLAAVYVFFCFLNRNTHELTFFFESSQNTPR----------------------ELQFLFKKTFRKVK--FHDLIKRATDKAMRSKRGHLDLFLRFLLGISLESSQNLLKGLFSHVIDTTRSIKKISPHFKHLQNKNI--SCDCSVNLFFCLLELKDHSLYEEIQRSLNSDRRPSKELSSSMCTVLTYIVLMSEKELDELNPKRFTSS-------------QENYRKLVP-AVRCCRKALFNGCGLDEMSFQTISSALQSSDSYLTELELSNNHLQDS--------------------------------------------------------------------------------------------------------------------GVKLLSDGLKSSHCQLNILRLCGCGLTDQSCESLSSALQSSNSVLRELDMSNNMLKDSGVKLLAVALKSLNCKLERLR-------------------------------------------------------------------FSMCNLTAESCESLSSVVELSNSVLRELDLSNN----------------------------------------------------------DLQDSGVKLLSDGLKR-NCRLEILRLSGCMVTEVGCGFLSSALSST------------------------------------------------------------------------------------------------------------------------TSTLRELDLSYNHPGDSGEKLLSDAHNQPNCR---LCVDHGGEFRLTTGLHKYARFFTLDPNTANARLILSEENRKVTCVRKKQPYPDHPDRFEGYL-QVLCRESVCGRSYWEIEWTG-VV--FISVSYSSIGRMGSD---KECWFGFSNQSWSLFCSS-DRCSFTHSSTEIDLPVKHTSSRIGVYVDHSAGTLSFYSVS-DTVSLIHSVQTTFTQPLHPGFYISLGSSVKLC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TTK4-1", "uniprot_id": "A0AB32TTK4_DANRE", "id": "A0AB32TTK4-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAMNRLMTDMLEELVEAELKQFTRQLWMGVKPGVDPIP-------------------------------------RGKLENKDR-----------------------------------------------------QDVVDCMVQHYSKDAGKIAVQALRSIKQNERADRLELNLRKDDDFLGEVLKKH-------------------------------------------------------------------------------------------------------KESIKASVD-VFEGK--KDNKTDINKVYTELFITEGDMTDVCKEHEVQKFDLALQMPRSEDKPIDCNEIFNLLR----------GKDKGNVVLTKGIAGIGKTFSVNKFILDWAEGRANLD-VDCMFLLPFREINLMIKDGDVSLHKFLLKLFPDITGVETTPFYEKCKLLFIFDGLDESRLDLNFN-LSSVDDVHSCASIDGLFTSLIKGRLLRSSLIWVTSRPAAANRIPSYHVG-LFTEVRGFTDKQKEEYFRKKVPDEDQASRIISHIRTSRSLYIMCHIPVFCWIIATVLQDILQ----------------KNKGED----IPSTLTEMYIHFLLIQMNIKNQKYDEKLIRDRTELLGSNRDMISKLAKLAFEQLKKENVMFYREDLAACGINAD--EEFTGLCTEIFKKDSVLHELKVYYFIHLSVQEFLAALHVFLCYLELEK--------DMNLTDS----------------------DLMFFLEDSRPKQKELLHVLLRKAIDKAEKSDRGHFDLFLRFLLGISLESNQKLLIGILNETKNSKQSISKTVQYLKQLQNNDK--CPDKSINHFFCILELQDRTLYQQIMKYLRSKTNRPKVMSRSNCSALVYVLLMSQEVLDKFNPKLFNKT-------------YAGCRILVP-AVRCSRKALFSDCGLTETCFETVALALQLENCPLVELDLSYNYSLEA--------------------------------------------------------------------------------------------------------------------AVNVMCAGLKSPHCHLESLRLAGCHLGQDSCMQVVSALQSISHRLKELDLSGNDLQDSGLQKLLQGMENTEKRLQVLR-------------------------------------------------------------------LSWCNLTEMSCQQLSTILS-SNSVFRELDLSNN----------------------------------------------------------DLQDSGVKLLSDGLKSPNCKLKILRLSGCMVTEEGCGFLSSALSSN------------------------------------------------------------------------------------------------------------------------PSHLRELDLSYNHPGQSGVQLLQHTLEDPHCKLKTLKTDPMGDHLMKPGIVKYAFNLTLNPNTAHVHLLLSDGDRKVT-LKEKQPYPDDPERFEEHH-QVLSRESLSGRCYWETEWTGQEG--TVGVAYESIPRKPDDLLYGRCMLGNNIISWKITCGSRTHVSHAEEDITVKSPSSGSCKRVGVYVDTTAGVLSFYHVF-DTLTHLYTFLMPFTQPLYAAFRVD-GESVSICPIP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "D4A523-1", "uniprot_id": "NLRP3_RAT", "id": "D4A523-1", "name": "NACHT, LRR and PYD domains-containing protein 3", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKMMSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCVPIPRGQMEKADHLDLAT-----------------------------------LMIDFNGEEKAWG--------------------------------------MAVWIFAAINRRDLWEKAKKDQPEWN--DACTSNLSMVCQEDSLEEEWIGLLGYLSRISICKKKK-------------------------------------------------------------------------------------------------DYCKIYRRHVRSRFYSIKDRNARLGESVDLNRRYTQLQLVKEHPSKQEREHELLTIGR-TKMWDRPMSSLKLELLFEPEDEHLEP---------VHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRAP---KSLADLIISCWPDPNPPVCKILCKPSRILFLMDGFDELQGAFDEHIEEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEILFTMCFIPLVCWIVCTGLKQQMET--------------GKSLAQT-----SKTTTAVYVFFLSSLLQSRGGIEEHLFSA-----------YLPGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMN--VFQKEVDCER--FYSFSHMTFQEFFAAMYYLLEEEEEGVTVRKGPEGC-----------------------------------------SDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS-CKISQQVRLELLKWIEVKAKAKKLQRQPSQLELFYCLYEMQEEDFVQSAMGHFPKIEIN---LSTRMDHVVSSFCIKNCHRVKTLSLGFLHNSPKEEEEEKRGSQPLDQVQCVFP-DPHVACSSRLVNCCLTSSFCRGLFSSLSTNQS-LTELDLSDNTLGDP--------------------------------------------------------------------------------------------------------------------GMRVLCEALQHPGCNIQRLWLGRCGLTHQCCFNISSVLSSSQ-KLVELDLSDNALGDFGVRLLCVGLKHLLCNLQKLW-------------------------------------------------------------------LVSCCLTSACCQDLALVLSSNHSLTRLYIGEN-----------------------------------------------------------ALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSLCCSALTSVLKTN-------------------------------------------------------------------------------------------------------------------------QNLTHLYLRSNALGDMGLKLLCEGLLHPDCKLQMLELDNCSLTSHSCWDLSTILTHNQSLRKLNLSNNDLGD--------------------------------------------------------------------------LCVVTLCEVLKQQGCLLQSLQLGEMYLNCETKRTLEALQEEKPELTVVFEISW------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R4B8-1", "uniprot_id": "NLRP3_MOUSE", "id": "Q8R4B8-1", "name": "NACHT, LRR and PYD domains-containing protein 3", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLAT-----------------------------------LMIDFNGEEKAWA--------------------------------------MAVWIFAAINRRDLWEKAKKDQPEWN--DTCTSHSSMVCQEDSLEEEWMGLLGYLSRISICKKKK-------------------------------------------------------------------------------------------------DYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQEREHELLTIGR-TKMRDSPMSSLKLELLFEPEDGHSEP---------VHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTP---RSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQQMET--------------GKSLAQT-----SKTTTAVYVFFLSSLLQSRGGIEEHLFSD-----------YLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMN--VFQKEVDCER--FYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGC-----------------------------------------SDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS-CKISQQVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEIN---LSTRMDHVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFP-DTHVACSSRLVNCCLTSSFCRGLFSSLSTNRS-LTELDLSDNTLGDP--------------------------------------------------------------------------------------------------------------------GMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQ-KLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLW-------------------------------------------------------------------LVSCCLTSACCQDLALVLSSNHSLTRLYIGEN-----------------------------------------------------------ALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTN-------------------------------------------------------------------------------------------------------------------------QNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLNLGNNDLGD--------------------------------------------------------------------------LCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFEISW------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96P20-1", "uniprot_id": "NLRP3_HUMAN", "id": "Q96P20-1", "name": "NACHT, LRR and PYD domains-containing protein 3", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLAT-----------------------------------LMIDFNGEEKAWA--------------------------------------MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKK-------------------------------------------------------------------------------------------------DYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK-TKTCESPVSPIKMELLFDPDDEHSEP---------VHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ---RSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES--------------GKSLAQT-----SKTTTAVYVFFLSSLLQPRGGSQEHGLCA-----------HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN--LFQKEVDCEK--FYSFIHMTFQEFFAAMYYLLEEEKEGRTN--VPGSR-----------------------------------------LKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS-CKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEIN---LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQS-LTELDLSDNSLGDP--------------------------------------------------------------------------------------------------------------------GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ-KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLW-------------------------------------------------------------------LVSCCLTSACCQDLASVLSTSHSLTRLYVGEN-----------------------------------------------------------ALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTN-------------------------------------------------------------------------------------------------------------------------QNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGD--------------------------------------------------------------------------LGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z7N0-1", "uniprot_id": "A1Z7N0_DROME", "id": "A1Z7N0-1", "name": "Leucine-rich repeat-containing protein 34", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCDVLLPCEYNPKECPSPAAE------------KSRLFTILLLYCWQR--EYDKRPYRQFQ--------FKRLTFEERIGRRYHCIRDLRIIVNYLLRRPQLSVQISSLVVSNWDAGLLKDFVR----------------------------SLLPVWYIELRLMRFPR----------------------EFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILR--------------------------EFLLVSKTLRRLNVSSCS----------------------------------------------------------LTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQ---------------------NTLWALSLEHCELTAQDMIPIAEHLARTNS-KFRRLRIACNKIGPDGAFFLLRGMSMG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNLELLDLSYCSIGTHGGEWVAKYLASCR-RLQVLHLNYNDMGPTAVNLILLAMKK-QCKLEKLT-------------------------------------------------------------------LYGNHFDSRTAMIVRRLLDAEVVLHSELDISYT-------------------------------------------------------------------YDEALQDYRVVPWR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : . *: : * *. :: : . . : * :.. . * . . . * : . : : :: : * .: .: ..: : . . * : *:*. . : :. * : :: . : . : : . ", "identical_positions": 11, "similar_positions": 53, "identity": "0.53%" }, { "cls_id": "homologset.agr.HGNC:16403", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K7Z1-1", "uniprot_id": "A0A0G2K7Z1_RAT", "id": "A0A0G2K7Z1-1", "name": "Zinc finger protein 346", "aln": "MECP---------------VPDFTEAADPGGAGPYKSSEEPEGREPDGVRFDRERARRLWEAVSGAQPAGREE--------------VEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVKRYLAIHG-METLKGDVKRLDSDQKSSRSKDKNHCCPVCNMTFSSPVVAQSHYLGKTHARNLK-------------------LKQQPAKGAALQQ------------HRETLDPDKFCSLCHSAFNDPAMAQQHYTGKRHRKQETKLKLMAHYGRLAGPTASDSPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQS-PKTLVTLGSQMPVQTQP---TPKDSSTVED------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0B7-1", "uniprot_id": "ZN346_MOUSE", "id": "Q9R0B7-1", "name": "Zinc finger protein 346", "aln": "MECP---------------APDATDAADPGEAGPYKGSEEPEGREPDGVRFDRERARRLWEAVSGAQPAGREE--------------VEHMIQKNQCLFTSTQCKVCCAMLISESQKLAHYQSKKHANKVKRYLAIHG-METIKGDVKRLDSDQKSSRSKDKNHCCPICNMTFSSPAVAQSHYLGKTHAKSLK-------------------LKQQSTKGAALQQ------------NREMLDPDKFCSLCHSTFNDPAMAQQHYMGKRHRKQETKLKLMAHYGRLADPAVSDLPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQS-PKTLVTLGSQTPVQTQP---TPKDSSTVQD------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UL40-1", "uniprot_id": "ZN346_HUMAN", "id": "Q9UL40-1", "name": "Zinc finger protein 346", "aln": "MEYP---------------APATVQAADGGAAGPYSSSELLEGQEPDGVRFDRERARRLWEAVSGAQPVGREE--------------VEHMIQKNQCLFTNTQCKVCCALLISESQKLAHYQSKKHANKVKRYLAIHG-METLKGETKKLDSDQKSSRSKDKNQCCPICNMTFSSPVVAQSHYLGKTHAKNLK-------------------LKQQSTKVEALHQ------------NREMIDPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKLKLMARYGRLADPAVTDFPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQS-PKTVASSLGQIPMQRQP---IQKDSTTLED------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2RV29-1", "uniprot_id": "ZN346_DANRE", "id": "A2RV29-1", "name": "Zinc finger protein 346", "aln": "MERL---------------VQRMYCLG---MRDPPPANIMAQ-QEPNGD-FP-------------YLPSGAAE--------------VNRMIKENSDLFSDSQCKVCSAVLISESQKLAHYQSKKHASKVRRYMSIHGSEEPIAKRFKPSGDDQSNVDEKDKYKACSVCNMTFSSPVVAQSHYQGKVHSKNLR-------------------MQSIGSQTPALPQPEAQAKKDDGMQGPAEQDPNRFCSICQASFNNPLMAQQHYSGKKHKKHMNKQKLMETFG----PSTAPASTVKGYPCTVCNIELNSVEQYQAHISGSKHKNHAKPKKGPNAFAPPPDNYQPDYQYPTNEDCLEDPAEWDSFNVAYE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0R2-1", "uniprot_id": "Q9W0R2_DROME", "id": "Q9W0R2-1", "name": "Matrin-type domain-containing protein", "aln": "MSCPGSLRGFHIPHLAPGETPKIRVDSACIESHPDAEISTSNRLVAPGKRTDKKDNGSIRTNMKRKAKCMEEDSLKANGDLALFPGRDESYPEELNRLIGPLNCQLCKVQMTSRKRARDHYESKAHDRHISAWLAKNY--TEVGLEAPPVKRLAKQGPTGPNAFHCELCNLDLTSSMHARQHYLGRKHKRVEQGVAKPSGARHCDTSVGRYGIGSLFRKPESLTKDSPTDVLISENSVIKSDDNERTCHLCKIVVTSAAQMQAHLAGARHQKNWRTSRQDQNHS------EAPIPETEKLDAAELALYRTPMGQYYCQPCNMMMNHES--TLQQHFIGKKHLKRVKN--LSQTEKNV--------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. . . * : . * : : :: . *: :*::* . : *..: **:** * :: ::: : : .. : * :**: ::*. *:.** *: * : : : . : :* : * :: * :*: .... * * * :*:*: . : .. : . : . : ..: ** .: .. ::.: . . : . : ", "identical_positions": 32, "similar_positions": 81, "identity": "8.63%" }, { "cls_id": "homologset.agr.HGNC:16404", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BJ95-1", "uniprot_id": "IL17F_RAT", "id": "Q5BJ95-1", "name": "Interleukin-17F", "aln": "--MKGSCETTMVKSLLLLMLGFAIISSGAARRNPKVGLSALQKAGNCPPLEDNSVRVDIRIFNQNQGISVPRDFQNRSSSPWDYNITRDPDRFPSEIAEAQCRHSGCINAQGQEDGSMNSVPIQQEILVLRREP-QGCSNSFRLEKMLIKVGCTCVTPIVHHAA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TNI7-1", "uniprot_id": "IL17F_MOUSE", "id": "Q7TNI7-1", "name": "Interleukin-17F", "aln": "--MKCTRETAMVKSLLLLMLGLAILREVAARKNPKAGVPALQKAGNCPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRHSGCINAQGQEDSTMNSVAIQQEILVLRREP-QGCSNSFRLEKMLLKVGCTCVKPIVHQAA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96PD4-1", "uniprot_id": "IL17F_HUMAN", "id": "Q96PD4-1", "name": "Interleukin-17F", "aln": "MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKH-QGCSVSFQLEKVLVTVGCTCVTPVIHHVQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5TKT4-1", "uniprot_id": "Q5TKT4_DANRE", "id": "Q5TKT4-1", "name": "", "aln": "----MSSALNLRFLMVACMMGLVLISFGAEG----ASVRSDQKNKNSHPEADHSYRLVLDAEFKAS-TNPIHPINNDSISPWTYMFTHNESLYPTSIAEAKCSLTGCL-IDGVEVQDYESKPIYTQIMVLRRIRGEKPNYSFKLEYKTIAVGCTCVRPYVEQL-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: ::*:.:: * .. ** .. * . : :: : : . . : ::. * *** * .* : :*:.:.:*:* **: :* * :* .* : :*:** : . **:** : ****** * :.: ", "identical_positions": 34, "similar_positions": 48, "identity": "20.73%" }, { "cls_id": "homologset.agr.HGNC:16405", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CY21-1", "uniprot_id": "BUD23_MOUSE", "id": "Q9CY21-1", "name": "18S rRNA (guanine-N(7))-methyltransferase", "aln": "MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPS-YLLDIGCGSGLSGDYISEEG-HYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGVPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVRGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTESQDADQASESMFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43709-1", "uniprot_id": "BUD23_HUMAN", "id": "O43709-1", "name": "18S rRNA (guanine-N(7))-methyltransferase", "aln": "MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPC-YLLDIGCGTGLSGSYLSDEG-HYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VHW6-1", "uniprot_id": "Q9VHW6_DROME", "id": "Q9VHW6-1", "name": "18S rRNA (guanine-N(7))-methyltransferase", "aln": "MA---RRPEHSAPPEIFYNDDEAKKYSTNTRIIEIQVEMAERALELLALPDDDESRLILDIGCGSGLSGSVLEDSE-HMWIGIDISKSMLDIAVEREVAGDVILGDMGEGMPFKPGTFDGAISISALQWLCNADKSYHNPHKRLLKFFTTLFSCLTRTARAVFQFYPENSDQIEMVTSQAMKAGFYGGLVVDYPNSAKAKKYYLVLMTGGSAELPQALGSPEEERRVN---YIKKRDACREARGKAPKKSRDWILAKKERRRRQGLETRPDTKYTARKRSGKF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25627-1", "uniprot_id": "BUD23_YEAST", "id": "P25627-1", "name": "18S rRNA (guanine(1575)-N(7))-methyltransferase", "aln": "MS----RPEELAPPEIFYNDSEAHKYTGSTRVQHIQAKMTLRALELLNL---QPCSFILDIGCGSGLSGEILTQEGDHVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISISAIQWLCNADTSYNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDDQVDDILQSAKVAGFSGGLVVDDPESKKNKKYYLVLSSGAPPQGEEQVN-LDGVTMDEENVNLKKQLRQRLKGGKDKESAKSFILRKKELMKRRGRKVAKDSKFTGRKRRHRF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: ***. .***:**:: **:** .:*: .**..*: ****** * . . :******:****. : :. * * *:*** :** .:.*: **::* *** *:**:.*:**..*****:******:.. . * :** ** :*:: * : .: * *:**:*.:*:: : .* *** **:*** *:* * **:** * :* .. : : : .:: : ..:: ::* *** :*:* :. *:::*.*** :*", "identical_positions": 109, "similar_positions": 84, "identity": "38.52%" }, { "cls_id": "homologset.agr.HGNC:16406", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LLR5-1", "uniprot_id": "A0ABK0LLR5_RAT", "id": "A0ABK0LLR5-1", "name": "EF-hand domain-containing protein 1", "aln": "MCVWRYLGVSRGPRVLFVARATRAAEGNRGGNCGAAMVTNPVHGLPLLPGSSFTDSTKTAFHRSQTLGYRNGYAFVRRPTMGIGGDRLPYNQLSPAELDELANKAPILTYGPLKQAAPAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRRVNIYYYLEDDSMSVIEPVVENSGIPQGKLVKRQRLAKNDVGDHYHWKDLNRGINLTIYGKTFRIVDCDRFTQDFLESQGIELNPSEKMPLDPYTELRKEPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPKVLVDNGKNFPQCVLEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMSDLPRVDVSKKEPPPVKQELPPYNGYGLIEDSAQNCFALVPKAPRKDIVKMLMNDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPVDNPIYYGPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIRKQDSPAPELECKQATEETKALATEELKAQGLDKLIEKIQMHLKDISCKDNLRERFQVYDKEESGYVDKETFFKVCETLNVPVDDSLIKELIRLCTHGEGRINYYNFVRAFSD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D9T8-1", "uniprot_id": "EFHC1_MOUSE", "id": "Q9D9T8-1", "name": "EF-hand domain-containing protein 1", "aln": "------------------------------------MGTNPVHGLPFLPGSSFTDSTKTAFHRSQTLNYRNGYAVVRRPTMGIGGDRLHYNQLSQAELDELANKAPILTYGPLKQAPLAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRHVNIYYYLEDDSMSVIEPVVENSGIPQGKLIKRQRFTKNDMGDHYHWKDLNRGINLTVYGKTFRIVDCDRFTQDFLESQGIELNPSEKIPLDPYTQLRKEPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPKVLVENAKNFPKCVLEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMPDLPPVDVTKKEPPPVKQELPPYNGYGLIEDSAQNCFALIPKAPRKDVVKMLMNDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPVDNPIYYSPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIQKPELPAPELESKQATGEPMVQGTEESKVQDLDALIDQIHMHLKYNSYKENLRETFQMYDKDESGYVDRETFFKICETLNVPVDDSLIKELIRLCTHGEGRINYYNFVRAFSN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5JVL4-1", "uniprot_id": "EFHC1_HUMAN", "id": "Q5JVL4-1", "name": "EF-hand domain-containing protein 1", "aln": "------------------------------------MVSNPVHGLPFLPGTSFKDSTKTAFHRSQTLSYRNGYAIVRRPTVGIGGDRLQFNQLSQAELDELASKAPVLTYGQPKQAPPADFIPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQVNIYYYLEDDSMSVIEPVVENSGILQGKLIKRQRLAKNDRGDHYHWKDLNRGINITIYGKTFRVVDCDQFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRVPKVLVENAKNFPQCVLEISDQEVLEWYTAKDFIVGKSLTILGRTFFIYDCDPFTRRYYKEKFGITDLPRIDVSKREPPPVKQELPPYNGFGLVEDSAQNCFALIPKAPKKDVIKMLVNDNKVLRYLAVLESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKYLGRTKVVKPYSTVDNPVYYGPSDFFIGAVIEVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQNHVRKREAPAPEAESKQTEKDP--------GVQELEALIDTIQKQLKDHSCKDNIREAFQIYDKEASGYVDRDMFFKICESLNVPVDDSLVKELIRMCSHGEGKINYYNFVRAFSN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :*******:***:**.*************.******.*****:******* :**** *******.***:**** ***. *:*:*************.********:* **:****:************************ ****:****::*** **************:*:******:****:*** ***********.**:.*****:***:*:**********************************::**** *********************:*************:*****:*.****:***********************.******************::**:***:.*** :**:*:**************:**:**********:****:**::***:**********.****************************************:********.:*.****:**.*****************:****************:************:::* : **** *.**: :. .* *: **: *: :** * *:*:** **:***: *****:: ***:**:*********:*****:*:****:***********:", "identical_positions": 524, "similar_positions": 88, "identity": "76.61%" }, { "cls_id": "homologset.agr.HGNC:16407", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9W3R8-1", "uniprot_id": "Q9W3R8_DROME", "id": "Q9W3R8-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "-----MQRLTKSLR------SLPFPAGKILRTQLVVRR---------------------------------------EYSSEIPDPVELSFDSYT------GENPETSPPLLTYHGLFGSKQNWRGISKALVRKVSRKVYAIDVRNHGESPHSSVHNSKAMSEDLRLFME-QRSHPN---AACMGHSMGGRSMMYFARKYPELVERLIVVDISPISVPRSTGEMTEIFDAMVSLD-----LSPSMSMSEGRKIAREKLLKATEDET---VDFIMLNLRKNPDT----------------GAFSWACNAHVLREFLTR--FDKYQSNLEELPPYTG-----PTTFICGTRSPYMRREQWPQIQKMFPNSEIHWL-DAGHLVHFEKPQEFLTIVSEFLNRTE----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A8I6AS56-1", "uniprot_id": "A0A8I6AS56_RAT", "id": "A0A8I6AS56-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "-----MPRTWQGLT--GVRRFLSRSVAAAVVAKETLIRGQSRTPGRWPFTGPLRTRPSRPRPSFSHGPFLLHSPHPYSMVAPPSRPLPLSYNLLD------GDA--TLPAIVLLHGLFGSKSNFNSLAKALVQRTGRRVLTVDARNHGDSPHSPDASYEAMSQDLQGLLP-QLGLVP---SVLVGHSMGGKTAMLLALQRPDVVERLVVVDISPAGTTPGS-YLGNFIAAMKAVD-----IPENIPHSRARKLADEQLSSVVKEAS---VRQFLLTNLVEVN-----------------GRFSWRVNLDALAQQLDK--ILTFP---QQLESYPG-----STLFLLGGNSPYVPPSHHSAIRRLFPQTQIQTVPNAGHWVHSDKPQDFMDAVISFLA-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4F5-1", "uniprot_id": "ABHDB_MOUSE", "id": "Q8K4F5-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "-----MLRWARAWR--VPRGVLGASSPRRLAVPVTFCS--SRSSG---------------------------------QENADLRPLPLSYNLLD------GDA--TLPAIVFLHGLFGSKTNFNSLAKAMVQRTGRRVLTVDARNHGDSPHSPDASYEAMSQDLQGLLP-QLGLVP---CVLVGHSMGGKTAMLLALQRPDVVERLVVVDISPVGTTPGS-HIGAFIAAMKAVE-----IPEKVPHSQARKLADKQLSSVVKEAG---IRQFLLTNLVEVG-----------------GRFSWRLNLDTLAQHLDK--IMTFP---QQREPYSG-----PTLFLLGGNSTYVQPSHHSEIRRLFPQAQIQTVPNAGHWVHSDKPQDFMDAVTSFLA-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFV4-1", "uniprot_id": "ABHDB_HUMAN", "id": "Q8NFV4-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "-----MLRWTRAWR--LPREGLGPHGPSFARVPVAPSS---SSGG---------------------------------RGGAEPRPLPLSYRLLD------GEA--ALPAVVFLHGLFGSKTNFNSIAKILAQQTGRRVLTVDARNHGDSPHSPDMSYEIMSQDLQDLLP-QLGLVP---CVVVGHSMGGKTAMLLALQRPELVERLIAVDISPVESTGVS-HFATYVAAMRAIN-----IADELPRSRARKLADEQLSSVIQDMA---VRQHLLTNLVEVD-----------------GRFVWRVNLDALTQHLDK--ILAFP---QRQESYLG-----PTLFLLGGNSQFVHPSHHPEIMRLFPRAQMQTVPNAGHWIHADRPQDFIAAIRGFLV-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DRD9-1", "uniprot_id": "ABHDB_DANRE", "id": "Q6DRD9-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "MSNFAMSALCRVFTRGAPCGLSSCSSVTGLRDFCSGVSRLDRAGS---------------------------------DSMRTASPVNLTYDVFD------GKG--DSTPLVFLHGLFGSKSNFHSIAKSLVQRTGRKVLTIDARNHGKSPHSPVLTYDTMTSDLTHLLG-QLHIGK---CVLIGHSMGGKVAMTTALSQPNLVERLVVVDISPSLTSAHT-NFHAYIQAMKEVK-----IPSDIPRSTARRLAEDQLRKIVKERS---VRQFLLTNLEEQN-----------------GQYGWRINLESISNHLED--ILGFP---EFDTTYEG-----PTLFLGGSSSAYISSDDYPEIQRLFPCADIQYIPDASHWIHADKPLDFISSIITFLQP------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53219-1", "uniprot_id": "IMO32_YEAST", "id": "P53219-1", "name": "Probable alcohol acetyltransferase", "aln": "----MMILGKAGILAQYGTIYVRQNTIRNNLSSCIFKQSLCAFHS------------------------------LAKVLQQKQVPLDLSYDIIKRDAVKTGDEGKPRPPIIILHGLFGNKLNNRSIGRNLNKKLGRDVYLLDLRNHGSSPHSSVHNYEVMSEDVKHFIT-KHELNTNGGPIIIGHSMGGKVAMMLVLKNPQLCSMLVCIENAPVSLRPNA-EFVEYIKALMEIV-----NDKGKTIRTLKQADEHLAERIGGNEL---VRRFLLTALKKVKMD--------NSSSVSSYTFEERIPLATLKDAIVKGEIAAWP-LDPARERWTR-----PALFIRATQSHYVVDEYLPIIGAFFPRFETRDI-DAGHWVNAEKPGECAESIVDFVERHED---", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VGJ4-1", "uniprot_id": "Q9VGJ4_DROME", "id": "Q9VGJ4-1", "name": "sn-1-specific diacylglycerol lipase ABHD11", "aln": "------MARQRLLG-----SILSKGGAQVLRNFQSFVQG--------------------------------------------TRLEYVSYTSPR--------NQMQAPPIVVMHDLNLSLESWRQVAVNLSQVGLRQVITVDARNHGLSPYITGHSPMHLAADVEALMS-HQRLNK---IVALGHGMGGRAMMTLALTQPQLVERVILVDITPAPVPSNFYLTRQVFEMMLQVAP---SIPSNLSLSEGRTFILPLFQDVVHDAS---ELRRIIYNLRKMQD----------------NTFGWAVNPQAVLSSWGEM-MINYEATLGGLRPYMG-----EVLLIAGSQSEFVTTTSIAVMQRYFPN-TVVQILDAGHCVYEDQPEQFVELVVEFTQTCLVC--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53208-1", "uniprot_id": "EAT1_YEAST", "id": "P53208-1", "name": "Ethanol acetyltransferase 1", "aln": "------------------MSRLAHNKALPYKIIVDLS------------------------------------------FHRTRLPSDVSSLIKFE----------QRPAIINIHGLLGSHVMFHSLNKLLSRKLDADIFSVDVRNHGISPKAIPYDYTTLTNDLIYFIETHIGLER--PIYLLGFSMGGKIALLTTLYKNINIRKCISIDLPPYETPELDPMILQNYDLIMRIIRRDVKILRGSPSWQKKVLELFKSLECNKRKCGGAVALYFANGFLSVKSNNVHQAQLHYEQQQHDPYINYSMPLSSMPNLLDE--VKKWPDLSNQRDFFQKGTASRKVLFMKGLQSNFIN-NDYSLLRYNFPCADVREF-NTGHNLLLENPEDSFKCILNFFAEETLDFE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: ..:: *.* . . : : : : :* **** ** :: *: :: : :*..***: : . : :: .* : : . : : . : . . : : . :: . * :: . : ** . ::.* : :.* : : * ", "identical_positions": 21, "similar_positions": 58, "identity": "5.2%" }, { "cls_id": "homologset.agr.HGNC:1641", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LKH2-1", "uniprot_id": "A0ABK0LKH2_RAT", "id": "A0ABK0LKH2-1", "name": "", "aln": "---------------------------------------------------------------------------------MGDSEEDRVQQ-LSSLDEEHLIASSTRYSLQGFRFQPPYILKKAAGYLCHGLVPFVLQLICLTLCAILLLAILIKVSNVAYSQGQEQAKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------EKVYQDVAQLKPQINH-----------------------------LCRPCPWDWTF----FQGNCYFFSKFQQN--WKDSVTSCRKLGAQLVVVKSDDEQS----FLQQTSKEKG----YAWMV----------------------LSDLKREGIWHWVDGSHLLFSFTKYWNKGEPNNE--------WEEDCAEFRGDG------WNDAPCTNKKYWICKKSALS-CTGK-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZW9-1", "uniprot_id": "C209C_MOUSE", "id": "Q91ZW9-1", "name": "CD209 antigen-like protein C", "aln": "------------------------------------------------------------------------------------------------------MRMHTR------------------------------------------LQFLKRVSNVAYSHGQEQAKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------EKVYKEMTQLKSQINR-----------------------------LCRPCPWDWTV----FQGNCYFFSKFQQN--WNDSVNACRKLDAQLVVIKSDDEQS----FLQQTSKEKG----YAWMG----------------------LSDLKHEGRWHWVDGSHLLFSFMKYWNKGEPNNE--------WEEDCAEFRGDG------WNDAPCTIKKYWICKKSAMS-CTEK-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZP17-1", "uniprot_id": "D3ZP17_RAT", "id": "D3ZP17-1", "name": "", "aln": "---------------------------------------------------------------------------------MSESKETGKQQ-LGPLDEELLTSSHTRYSMKGFGFQPNSGFSSFTGYLVHSHVPLALKALFLTVFSVLLVVILVKVYKIPSSHEQEESNQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------KNFYQELIQLKAGVDR-----------------------------LCRSCPWDWTA----FQGNCYFFSVAQKS--WNDSATACHNVGAQLVVIKSEEEQN----FLQKTSKKRG----YTWMG----------------------LIDINKESTWHWVDGSPLTLTFMKYWNKGEPNNV--------GDKDCAEFREDG------WNDTKCDNKKFWICKKPETS-CSSK-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZX1-1", "uniprot_id": "C209A_MOUSE", "id": "Q91ZX1-1", "name": "CD209 antigen-like protein A", "aln": "---------------------------------------------------------------------------------MSDSKEMGKRQ-LRPLDEELLTSSHTRHSIKGFGFQTNSGFSSFTGCLVHSQVPLALQVLFLAVCSVLLVVILVKVYKIPSS--QEENNQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------MNVYQELTQLKAGVDR-----------------------------LCRSCPWDWTH----FQGSCYFFSVAQKS--WNDSATACHNVGAQLVVIKSDEEQN----FLQQTSKKRG----YTWMG----------------------LIDMSKESTWYWVDGSPLTLSFMKYWSKGEPNNL--------GEEDCAEFRDDG------WNDTKCTNKKFWICKKLSTS-CPSK-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NNX6-1", "uniprot_id": "CD209_HUMAN", "id": "Q9NNX6-1", "name": "CD209 antigen", "aln": "---------------------------------------------------------------------------------MSDSKEPRLQQ-LGLLEEEQLR---------GLGFRQTRGYKSLAGCLGHG--PLVLQLLSFT----LLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVER-----------------------------LCHPCPWEWTF----FQGNCYFMSNSQRN--WHDSITACKEVGAQLVVIKSAEEQN----FLQLQSSRSNR---FTWMG----------------------LSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNV--------GEEDCAEFSGNG------WNDDKCNLAKFWICKKSAAS-CSRDEEQFLSPAPATPNPPPA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q91ZW8-1", "uniprot_id": "C209D_MOUSE", "id": "Q91ZW8-1", "name": "CD209 antigen-like protein D", "aln": "---------------------------------------------------------------------------------MSDSMESKTQQ-VVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------VQNKIYQELMQLKAEVH----------DG------------------LCQPCARDWTF----FNGSCYFFSKSQRN--WHNSTTACQELGAQLVIIETDEEQT----FLQQTSKARG----PTWMG----------------------LSDMHNEATWHWVDGSPLSPSFTRYWNRGEPNNV--------GDEDCAEFSGDG------WNDLSCDKLLFWICKKVSTSSCTTK-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZXN3-1", "uniprot_id": "D3ZXN3_RAT", "id": "D3ZXN3-1", "name": "", "aln": "-MCFKSGLRAHLIVPILEWETPAFWTSAEYNTLCFYILFECRVSFLGESWTLRKHECLESGYKGTTKTGLSQTRALAIAVTMSESMESNTQQ-LDNPEDEEYLMSGSRYSIISSRLRTKFGIKSLAEYTKQSHNPLVLPLLSFLFLAGLLLIILVLVSKVPSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------VQDKIYQELMQLKTEVH----------DG------------------LCQPCPRDWTF----FNGSCYFFSKSQRN--WHNSITACKELGAQLVIVETDEEQT----FLQQTSKTRG----PTWMG----------------------LSDMHNEATWHWVDGSPLSPSFAQYWNRGEPNNV--------GDEDCAEFSGDG------WNDLRCDTRIFWICKKVSTSSCTIK-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CJ91-1", "uniprot_id": "C209B_MOUSE", "id": "Q8CJ91-1", "name": "CD209 antigen-like protein B", "aln": "---------------------------------------------------------------------------------MSDSTEAKMQP-LSSMDDDELMVSGSRYSIKSSRLRPNSGIKCLAGCSGHSQVPLVLQLLSFLFLAGLLLIILFQVSKTPNTERQKEQEKILQELTQLTDELTSRIPISQGKNESMQAKITE---------------------------------------------------------------------------------------------------------QLMQLKTELLSRIPIFQGQNESIQEKISEQLMQLKAELLSKISSFPVKDDSKQEKIYQQLVQMKTELFRLCRLCPWDWTF----LLGNCYFFSKSQRN--WNDAVTACKEVKAQLVIINSDEEQT----FLQQTSKAKG----PTWMG----------------------LSDLKKEATWLWVDGSTLSSRFQKYWNRGEPNNI--------GEEDCVEFAGDG------WNDSKCELKKFWICKKSATP-CTEG-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZCF3-1", "uniprot_id": "D3ZCF3_RAT", "id": "D3ZCF3-1", "name": "", "aln": "---------------------------------------------------------------------------------------MRIQQ-MGS-----------------------------LGFLDRSNIPLVLQLLFLILFAGLLVAIVIQVSKIPSSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------VQWEQTKQEKMYQDLSQLKSEIDS-----------------------------LCRLCPWDWTF----FNGNCYFFSKSQRD--WHNSITACQEMEAQLVTIKSPEEQS----FLQQTSKKNG----YTWMG----------------------LSDLNKEGEWYWLDGSPLSDSLRNYWNEGQPNNI--------DGQDCVEFRNDG------WNDAKCDNWKFWICKKTATT-CSSK-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZW7-1", "uniprot_id": "C209E_MOUSE", "id": "Q91ZW7-1", "name": "CD209 antigen-like protein E", "aln": "---------------------------------------------------------------------------------------MRAPQ-MGS-----------------------------LGFLDKGHIPLVLQLLFLILFTGLLVAIIIQVSKMPSSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------IQWEHTKQEKMYKDLSQLKSEVDR-----------------------------LCRLCPWDWTF----FNGNCYFFSKSQRD--WHDSMTACKEMGAQLVIIKSHEEQS----FLQQTSKKNS----YTWMG----------------------LSDLNKEGEWYWLDGSPLSDSFEKYWKKGQPNNV--------GGQDCVEFRDNG------WNDAKCEQRKFWICKKIATT-CLSKW----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6A230-1", "uniprot_id": "A0A8I6A230_RAT", "id": "A0A8I6A230-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------MQCQVREGPNLEGLRRCMIMCIQAFIYPD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPLPIDS---------------------------------LCRPCPWEWTF----FHGRCYYFSKSQRN--WNDSVAACQEVDAQLVTVESDEEQT----FLDTFLKNKG----PAWMG----------------------LSDLKQESTWQWVDGSPLSDSFRKYWIKGEPNNQ--------GNEDCAELREDG------WNDNKCDNKKFWICKKPETS-CSSK-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F1QW96-1", "uniprot_id": "F1QW96_DANRE", "id": "F1QW96-1", "name": "", "aln": "-----------------------------------MNTLSYREEDRGKKAVIKAAMSRAEAHKDSDGLLKDKMSDIYEAVESTGPDGERVEM-MVNIYESADYVIDHDLQTNPQQPLQQTGSICLKKRRSRASPVCVVLLCSLLMTAVTVLSLYVYTNYTQETRITSLTEERDQLLTNITNLTEEKAKLLASNTNLKVEKDQQ----------------------------------------------------------------------------------------------------LKMMKAMKDQLENIIKNLLKENKQFSSKNEDLLKQSAQLKKEKKD---------------------------LEKRLHEQDSWFY----FQSSFYFISSEERN--WTESRRYCRDKGADLIIINNREEQD----HVKKMS--GGF---TVWIG----------------------LTDS--DDRWKWIDGTNMTTGFR-FWNHGEPNGQ--------GGENCVTSRSSG------WADYPCFYPFPWICEKNTLK-CQ-------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IRH8-1", "uniprot_id": "Q8IRH8_DROME", "id": "Q8IRH8-1", "name": "", "aln": "-------MIRPTLIVVLISLASVDSGHNSPVTTIPVAEPISQVPHGFQLGQNNHISSSSNISRSGGGNGRDKRGAQLDPSEIARQNQITQQI-FANYLERRLFPNRTANQKIPTIADILPKPKPSPRPRPRGFAASDGGNFKRSGGGAQRNRLAAAASKRQSGYNRKRLREEQEEEEEADDQER-------------------------------------------------------------------------------------------------------------------------DQQPLANQEDFDYDVQESLQSVESEQHDQYYGNIFHRDPSENEVDNDCPN-------------------CVDESQYTPNKWTMPLLKLGEKRYYLGIFFKAN-WFKATQYCRYHGMHLASISSQEEND----RLEKHIRDFGLGHEHFWIS----------------------GTDLADEGNFFWMATG--RPITFTNWNAGEPNNFRY---ENGEEENCLELWNRDGKG-LKWNDSPCSFETYFVCEVQPN-----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VQU4-1", "uniprot_id": "Q9VQU4_DROME", "id": "Q9VQU4-1", "name": "", "aln": "-------------------------------------------MFRLSVLVLNLLLVSHEFSAGTAKIEIQPLPALCNGYCFPTLKPVMEYV-AIHQDKWNTCTEILANEARKDQIQLNIQLDALKADVSNIKASQLSKDEKLDRMEREQFAMHESLETINRYLTVKLDRT-------------------------------------------------------------------------------------------------------------------------------------------------------------KLQLEAIKNTMDYMKAQMDG----------------------------YFSAINGVQCLQPGFEKIGDRYFYIEEDVELNWLDAQAKCRRMGGHLASIKTKQEFD----AIVEKLDDSK----SYFLG----------------------VNENTKTGDFVSAASG--KSCLYHEWGPGEPHHN-------NDQERCVSILRKL------MHVGNCTYEKRFICQYGI------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "B7Z0K3-1", "uniprot_id": "B7Z0K3_DROME", "id": "B7Z0K3-1", "name": "C-type lectin domain-containing protein", "aln": "MPPAGQQLRLTALVYLALGIALLCNGSDGETRQKYANESLADADDPSPVWSQFLEDYVLSQGSSSSGSQRKSKDLPYMGADMGINGPLSYHSSAYKRPGNNIYITRRIGEAVELEPHLRKPVESQSPIVNPQFRPMTNQMLHQQHQQMQQQQQQQQLQQRQQPGFLQQLFGIGGSGGGGGSGTQQQQHVRPVPLQQQQVQQIAQQHP--------------------------------------------------------------------------------------------------QQQHLVGGQPTTFRAVSENDLYLLGAIEKLVYRVDYLESRVRRSEQLIYYLMAGNN-------------QKEVKDPCPANFTR----ISDNCYYINSQQQVN-WKTANSACKGLNSHLAEFEKVSENEEIMAYLLNQPTHRGR---DYWLGGLNPGLLWIWSNSAKPVNPNMNLTSIAMAQKGENSTAANLVDSSEQAAEEATGEDVLNNTVQIEGKGRCLRLSYNAGKHSYVYYGQECTSRHYYICEHEDKTLDNKIKKITRELKLFE------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . *: * : *: .* ... .* : :: . . . * * ::*: ", "identical_positions": 8, "similar_positions": 19, "identity": "1.38%" }, { "cls_id": "homologset.agr.HGNC:16410", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P59041-1", "uniprot_id": "DJC30_MOUSE", "id": "P59041-1", "name": "DnaJ homolog subfamily C member 30, mitochondrial", "aln": "--------------------------------------------------MAAARCLGWTLSPLWRWWQVRGLPPSSATGLCSRGR------------TYS-------RTALYELLGVPSTATQAQIKAAYYRQSFLYHPDRNPGSAEAAERFTRVSEAYLVLGSTILRRKYDRGLLSDQDLRGPGVKPSKTPVADPAPPRPPPYTPRAPGGSRASPGDGRTMFDFDAFYQAHYGEQLERERRLRARREALRKKQENQANKGTSWDDTRDATFFVVLFLIFVFVGFRI---------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96LL9-1", "uniprot_id": "DJC30_HUMAN", "id": "Q96LL9-1", "name": "DnaJ homolog subfamily C member 30, mitochondrial", "aln": "--------------------------------------------------MAAMRWRWWQRLLPWRLLQARGFPQNSAPSLGLGAR------------TYSQGDCSYSRTALYDLLGVPSTATQAQIKAAYYRQCFLYHPDRNSGSAEAAERFTRISQAYVVLGSATLRRKYDRGLLSDEDLRGPGVRPSRTPAPDPGSPRTPPPTSRTHDGSRASPGANRTMFNFDAFYQAHYGEQLERERRLRARREALRKRQEYRSMKGLRWEDTRDTAAIFLIFSIFIIIGFYI---------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F8P1-1", "uniprot_id": "E7F8P1_DANRE", "id": "E7F8P1-1", "name": "", "aln": "MAEVTGSVRNAVNKLSAFKTLLSLHHHPHGPVVDSRALCRKSNVCVHWCAADCVWALHNKHAQLYRPQISGCYTLVSAKHWCLLLRPVGSRLYSCRTADESSGLLHRSRTAYYDILKVSPNATHAQIKSAYYKQSFIYHPDRNR-SEDAARQFALVAEAYNVLGSSSLRRRYDRGILTQKEVQSSGR---------PAAPPPP---------RRAPASGKTAHFDFDAFYQAHYGEQLQREKLQRLRQQQIQQRRMEMQKQWRREQITGVSVILLLLLGGVIINSLKS---------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VHW5-1", "uniprot_id": "Q9VHW5_DROME", "id": "Q9VHW5-1", "name": "J domain-containing protein", "aln": "--------------------------------------------------------MYQHSPMLWR-------PLLLLRGLYLSQR---------------------HQMSHYDALGIRRQCTQNEIKAAYYKLSMLYHPDRNQGSENAAKKFREINQAYEILGNYRLRRLYDKGIVHTAGAQYAQDVHDVAEPVVEDDAETKFYKSRFQKSRVSDSAGRTPIYDFDEWSRNHYGKSFDRRQAAQAKYDRIKVQRETNRISGQTDMVLLAFIFAGVAVYLMFLAESSYDTPKQKAKERYRRDQEEREQKLVGKQS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* . * : : *: * : .*: :**:***: .::****** * :**.:* : :** :**. *** **:*:: : . . . : .. . ::** : : ***:.::*.: : : : :: :: . : . ..: ", "identical_positions": 36, "similar_positions": 55, "identity": "11.43%" }, { "cls_id": "homologset.agr.HGNC:16411", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q32PX9-1", "uniprot_id": "AFG1L_RAT", "id": "Q32PX9-1", "name": "AFG1-like ATPase", "aln": "-MAASWSPLVTLRSAARSRLTGRGVGCGARVIAIFPPAPGPRKPLWKAYTVQTLEGVRPTAASEAHSRALAVCHGPLAHYDFLIKAQE--LKNDEHQRRVVQCLQKLQEDLKGYN---------------IEEGGLFSKLFSR-------------------------NKPPKGLYVYGDVGTGKTMVMDMFYEYVE-VKSKRRVHFHGFMLDVHKRIHRLKQSLPKRKVG-FMAKSYDPIAPIAEEISQEASLLCFDEFQVTDIADAMILKQLFENLFKN--GVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGVDYRKRELTPAGKLYYLTSE----------ADVGTVMDKLFDELAQKQNDLTSPR-----------ILKVQGRELRLNKACG-TVADCTFEELCERPLGASDYLELSKNFDTVIIRNIPQFSLAKRTQVRRFITLIDNFYDFKVRIICSASVPISSLFVY--------------QHQDS-ESDQSRVLMDDLGLSQDSAG-LSMFTGEEEIFSFQRTLSRLTEMQTEQYWIEGDRSRK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3V384-1", "uniprot_id": "AFG1L_MOUSE", "id": "Q3V384-1", "name": "AFG1-like ATPase", "aln": "-MAASWSPLVTLRSAARSRLTGRGVGCGARVVAIPPPAPGPGKPLWKAYTVQTSEGVRPTAASEARLKALAVCHGPLDHYDFLIKSQE--LREDEHQRRVVQCLQKLQEDLKGYS---------------IEEGGLFSKLFSR-------------------------NKPPKGLYVYGDVGTGKTMVMDMFYAYVE-TKRKKRVHFHGFMLDVHRRIHHLKQSLPKRKAG-FMAKSYDPIAPIAEEISQETSLLCFDEFQVTDIADAMILKQLFENLFKN--GVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCDTLQLDSGVDYRKRELAPAGKLYYLTSE----------ADVEAVVDKLFDELAQKQNDLTSPR-----------ILKVQGRELRLNKACG-SVADCTFEELCERPLGASDYLELSKNFDTVIIRNIPQFSLAKRTQARRFITLIDNFYDFKVRIICSASAPISSLFLH--------------QHQDS-ESDQSRILMDDLGLSQDSAG-LSMFTGEEEIFAFQRTISRLTEMQTEQYWIEGDRSRK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WV93-1", "uniprot_id": "AFG1L_HUMAN", "id": "Q8WV93-1", "name": "AFG1-like ATPase", "aln": "-MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTATSETYLKALAVCHGPLDHYDFLIKAHE--LKDDEHQRRVIQCLQKLHEDLKGYN---------------IEAEGLFSKLFSR-------------------------SKPPRGLYVYGDVGTGKTMVMDMFYAYVE-MKRKKRVHFHGFMLDVHKRIHRLKQSLPKRKPG-FMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKN--GVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSE----------ADVEAVMDKLFDELAQKQNDLTRPR-----------ILKVQGRELRLNKACG-TVADCTFEELCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLH--------------QHHDS-ELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "X1WDT8-1", "uniprot_id": "X1WDT8_DANRE", "id": "X1WDT8-1", "name": "", "aln": "-MAAGKASLAALG---LQFCVGNKLLSKSNLPCIISRVR---RGFSTSVLSQTID-----ESSASTSPSSSCFGGPLEHYNSLVRDGQ--LREDLQQRAVVEKLDQMQKNLRGYN---------------NDHSTFFSKFISK-------------------------RKPPKGYYIFGDVGTGKTMVMDMFFNHVE-TEKKKRVHFHGFMLDVHKRIHRLKQSLPKRKVG-RMAKAYDPIAPVAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFLN--GVVVVATSNRPPDDLYKNGLQRVNFVPFIAVLKEYCQTLRLDSGIDYRRRNRPAAGKLFYLSSE----------PDVDATLDKLFDEMAFKQNDITRPR-----------SLKVHGRILTLDKACG-TIADCTFEELCDRPIGASDYLEISAVFDTVFIRNIPLLTLNKKTQARRFITLIDTLYEHKVRVVLKAETPLDDLFVH--------------EHHDDHDPHETHVLLDDLGISRDAGSSLAIFTGEEEVFAFQRTVSRLTEMQTEEYWVAGDRSTN", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q5TYS0-1", "uniprot_id": "LCE1B_DANRE", "id": "Q5TYS0-1", "name": "Lactation elevated protein 1 homolog B", "aln": "-MAAYAS---RWRTDCLLRLVFKKTRLSKQVCCEVCKAS---RGCSTTSTGHTST-----------SAPWPVYGRLVTHYDSLVHFGS--LRKDPQQRTALLQLEELTRVLTDYTNIPILLPQPKDCLQNQPTSELQDKVGSRETVNICRPDENVSNEKEDQQEESSKPHPPQGYYIYGNVGTGKTMLMDLFYSFVE-NRRKKRVHFNGFMLDVHRRIHKLKQSLPKRRIG-KMT-MYDPIFPVAMEIAEETCLICFDEFQVVDIADAMILKQLFEGLFKC--GVVVVATSNRPPEELYKNGLQRAAFVPFIGVLKEYCRIVSLDTGIDFRTREMKPAGRLYYISSE----------PDAENAVNALFEELAFRQNDVTRPR-----------VLNVQGREVTLSRTCG-TIADCSFQELCEQPLGAGDYLEIARCFDTVIIRNVPYLQLGMKDQARRFTTLIDNFYDQKVRVVMLADAPLDRLLDQ--------------GQMTG-EEARDRLMLDELGLTDEASKRITLFTADEEIFAFQRTVSRLAEMQTEQYWISGDRSQS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P32317-1", "uniprot_id": "AFG1_YEAST", "id": "P32317-1", "name": "Protein AFG1", "aln": "MIALKPNAVRTFRQVQHCSFRICRYQSTKSNKCLTPLQEYDRLVKLGKLRDDTYQR--------------GIISSLGDLYDSLVKYVPPVVKTPNAVDQVGGWLNGLKSVFSRGK---------------PKNIGAYVDVSKIG------------------------NSIPRGVYLYGDVGCGKTMLMDLFYTTIPNHLTKKRIHFHQFMQYVHKRSHEIVREQNLKELGDAKGKEIDTVPFLAAEIANNSHVLCFDEFQVTDVADAMILRRLMTALLSDDYGVVLFATSNRHPDELYINGVQRQSFIPCIELIKHRTKVIFLNSPTDYRKIPRPVSSVYYFPSDTSIKYASKECKTRRETHIKEWYNYFAQASHTDDSTDSHTVHKTFYDYPLTIWGREFKVPKCTPPRVAQFTFKQLCGEPLAAGDYLTLAKNFEAFIVTDIPYLSIYVRDEVRRFITFLDAVYDSGGKLATTGAADFSSLFVEPEQILNDFELRPTTKEPDSVDTGMVDEMVEKHGFSKEIAKKSQMFALDEERFAFARALSRLSQMSSTDWVTKPTY---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* . .* *: *:: :: . *: : : . .. . *:* *::*:** ****:**:*: : *:*:**: ** **:* *.: :. :. * *.: :* **:::: ::*******.*:******::*: *: ***:.***** *::** **:** *:* * ::*. : *:: *:* :. :: :. . :. :: :* .: . *.: ** . : : :*: :*::** .*:.*.*** :: *::.:: ::* : : : : *** *::* .*: :: . . :. *: . . : :::. *:: : . :*: :** *:* *::***::*.: :: ", "identical_positions": 104, "similar_positions": 138, "identity": "18.41%" }, { "cls_id": "homologset.agr.HGNC:16412", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M649-1", "uniprot_id": "NLRC4_RAT", "id": "F1M649-1", "name": "NLR family CARD domain-containing protein 4", "aln": "MNFIKENSQALIQRMGIVVIKQICDDLFALNVLNGEEVAIICSHRVEQDAARDIVHMILKKGSAACNLFLKSLENWNYPVYQDLTGHSLFHQNLEEDLDVLAQSLKDLYNSPVFKNFFPLGEDIDIIFNLQITFTEPVLWRKDHRHHRVEQMTLGSLLEALKSPCLIEGESGKGKSTLLQKIAMLWASGMCPALNQFKLVFFIRLSSARGGLFETLYDQLVNIPDSISKPTFRALLLKLHKKVLFLLDAYNEFHPQNCPEIEALVKENHRFKNMVIVTTTTECLRHIRHVGALTVEVGDMTEDSARVLIREVLINELAEGLLFQMQESRCLRNLMRTPLFVVITCAIQMGSEEFQAHTQTMLFQTFYDLLIQKNRRRHSGGTSGDFVRSLDYCGDLALEGVFSHKFDFELEDVCSMNEDVLVRTGLLCKYTAQRLRPTYKFFHKSFQEYTAGRRLSSLLKSREPEEVSKGNSYLKKMVSISDITSLYGNLLLYTCGSSTEATRAIMRHLAMVCEHGSLQGLSVTKRPLWRQESIQNLRNTTEQDVLKAINVNSFVECGINLFSESISKSELSQEFEAFFQGKSLYINSENIPDYLFDFFKYLPNCVSALDFVKLDFYGRATVSQDKTGENSSGVHTEGPS-TYIPSRAVSLFFNWMQKFKTLEVTLRDISKLNKQDIKYLGKIFSSASNLKLYIKRCAAVAGRLSSVLRTCKNIHSLMVEASPLTTEDEQYITSVTDLQNLSIHDLHTQRLPGGLADSLGNLKNLLKLILDDIRLNEEDAKSLAEGLRNLKKMRLLHLTRLSDMGEGMDYIVKSLSEEPCDLQEMKLVDCCLTANSLKILAQNLHNLVKLSVLDMSENYLEKAGSEALQGLIGRLGVLEQLSALMLPWCWDAYISLPNLLKQLEGTPGLVKLGLKNWRLRDEEIRSFGEFLEMNPLRDLQQLDLAGHGVSSDGWLSFMDVFENLKQLVFFDFGTEEFLPDAALVRKLGQVLSKLTLLQEARLTGWELDDYDISVIKGTFKLVTA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UP24-1", "uniprot_id": "NLRC4_MOUSE", "id": "Q3UP24-1", "name": "NLR family CARD domain-containing protein 4", "aln": "MNFIRNNRRALIQRMGLTVTKQICDDLFALNVLNNQEANVIYCEPLEQEAARKIIHMTMQKGSAACNLFLKSLENWDYFVYQDLTGQNLSYQVTEEDLNVLAQNLKDLYNSPAFLNFYPLGEDIDIIFNLEKTFTEPIMWKKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGGCRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLHKEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLFVVITCAIQMGRQEFQAHTQTMLFQTFYDLLIQKNSHRYRGGASGDFARSLDYCGDLALEGVFAHKFDFEPEHGSSMNEDVLVTIGLLCKYTAQRLKPTYKFFHKSFQEYTAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTCGSSTEATRAVMRHLAMVYQHGSLQGLSVTKRPLWRQESIQSLRNTTEQDVLKAINVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDFFEYLPNCASALDFVKLDFYERATESQDKAEENVPGVHTEGPSETYIPPRAVSLFFNWKQEFKTLEVTLRDINKLNKQDIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMHTLMVEASPLTTDDEQYITSVTGLQNLSIHRLHTQQLPGGLIDSLGNLKNLERLILDDIRMNEEDAKNLAEGLRSLKKMRLLHLTHLSDIGEGMDYIVKSLSEESCDLQEMKLVACCLTANSVKVLAQNLHNLIKLSILDISENYLEKDGNEALQELIGRLGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRDEEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQLVFFDFSTEEFLPDAALVRKLSQVLSKLTLLQEVKLTGWEFDDYDISAIKGTFKLVTA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NPP4-1", "uniprot_id": "NLRC4_HUMAN", "id": "Q9NPP4-1", "name": "NLR family CARD domain-containing protein 4", "aln": "MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****::* :*******:.* *** ****. **** :*. :* .. :**:*** *:** ::*** :********::*:* ::***.*:.* :* * **: ***.*****::* * **:************: *****::*:**::******:**..**:**:***:**************:*****.** * **. *::***::* *:******* ***::**. * * ** *:****::.******.****:**********:***********************:.****.**********: **. **: : .* * *:*:********:************** .**::**** **:********** ::: * ::.** ****:**********:****** :. .*:*****: **********::*.*********************.*:*****:***.**:********** *..** ******.*****:*:*** * :**.* ***::*********:*.::*****::*****:********:*:.** *** ****************** **********::****.*****:***** * * :*: *: *:* * .. ****.********* *:*:********:.*******:*********:.*:* *****.:** ** ** ****:::********* :**::*****.*:.**** *:.*:***** ********* :**:*:*::***** .*****:.**** *:***:***:************.*.***:*::** ***:**::*:********:***:**:******* *.***: **.*:.** :*::***** *. **..***:** .* *.********* * **: :* *: ***:::***:***: ******* **.*************.*:*****.******.*******:***.:*.**::** *:*.*.*:******", "identical_positions": 719, "similar_positions": 209, "identity": "70.21%" }, { "cls_id": "homologset.agr.HGNC:16421", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JTZ2-1", "uniprot_id": "SOX6_RAT", "id": "A0A0G2JTZ2-1", "name": "Transcription factor SOX-6", "aln": "-----------------MSSKQATSPFACTVDG-EETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRER-EIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQ-VQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQ-PHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQP--QIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P40645-1", "uniprot_id": "SOX6_MOUSE", "id": "P40645-1", "name": "Transcription factor SOX-6", "aln": "-----------------MSSKQATSPFACTADG-EEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRER-EIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQ-VQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQ-PHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQP--QMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P35712-1", "uniprot_id": "SOX6_HUMAN", "id": "P35712-1", "name": "Transcription factor SOX-6", "aln": "-----------------MSSKQATSPFACAADG-EDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDR-EIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQ-VQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINQRLKGLSDRFGRNLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQP--QIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TT03-1", "uniprot_id": "A0AB32TT03_DANRE", "id": "A0AB32TT03-1", "name": "", "aln": "MLNMEGFLRSSFLLSRIMSSKQATSPFTSTPDGGEDGVNQERMPWEKEENSESLVAPQLPLHNLLHNKPPLEELQPISSSVPPESDWDSLMSAQQRMESDSNKVCSLYSFRNNSTSPHKPEEGARERGDLLSSSAFGTPERRKGSLADVVDTLKQKKLEEMTKTEQDESSCMEKLLSKDWKEKMERLNTGELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQMEKQRQQMELARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGMSYKPGDNYPVQFIPSTMAAAAASGLNPLQLQ-----------------------------------------QLYAAQLASMQVSPGAKMPPLPQPPNSAGQISPSGLKNEKRSSTPLAQVKEEG-TQPLNLSARPKTAEPIKSPTSPTQSLFPGSKSSPNSLSKSGDIPSPIGG-LGRGSSLDILSSLNSTALFGDQDAVMKAIQEARKMREQIQREQLQHHQQGMEVKLSALTSMGLNNCRTEKERSHYDNLGHHLS-KLGEDGKIGHRVIDLTRPEDFEGCRELNGCADKPHQYYCWPTGGASTTEARVYREPRGRNSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMTNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIIDGKKLRISEYKQMMRSRRQEMRQFFTVGQQPQTQIPITTSAGVVYPGAITMATTTPSPHMTSDCSSASASPEPTIPVIQSTFNMKMEPGTMVPSDAVNGEDEMDMYEDFEDEPKSDYSSENDTHEPVSAN--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q59DN5-1", "uniprot_id": "Q59DN5_DROME", "id": "Q59DN5-1", "name": "", "aln": "---------------------------------------MKPPGEDQTNEKEHSDLGMIKQLQLIRNRILSQAHYDSMTDIDASAQQQQQLQNVQRLQHES----CLQELHNHLSSQYG-----------------------------AVRFTAANPQHQNQQAVSVSSGNLMPFLPAFLQPPMP--NAQQLLQLIPGHENAQSVPTHHHSHPQSEAFSTHKMALAPMWSTAAVAAAHIQAALAAAAVAAANNN---KNSSHFSNNTNIVGLATRGNE---------LLNTDSDPQMEIGETRRGGNGGSCRSRPESPTYENPPYEILSYSHNTPPES--------------------------------------------------------------------PHGRTADCSKNFSPSPTDN--LSIASVSEAQDSEMDAPLNLSK--PKGSPSSSPNSSSQ----------------------------RDHCENLTPVVSSPPLSWHQGQPHYAEIELPLLKSHG-RVWNSAVACSGGSRATRVSRDSVNSCGTNSERS------AALDPESLNSGQLGPVPASPSSQPLRQGNGHGHG-------------------------GNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCR-------------TGGVSGGSGSLCADACP---KGSGGSNSQVAVAAAAAVYHLQDMASSAASTAHGHDCGHTPPQQFFYPPESLSPSGFSSDEVELASQRELDD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: : .: : :::*: : : : .:: :. :. **:: :. .* .::* :* : .* : .: :: . .*. : :*. : * *: :** * * :: : :: * :: :* :: **. . :**:::: :* ::: ::..:: :: : :.* : : :: .. * :. : . :* . . :* * :::. : :.. * . :..: : .**: .* . :.:::.::. ***** ...* .**.*.:* *. . :: . :.*..* .*. * * ::.: * . . : : :. .:..* .:.**: * : :.*::* . : :* :* :*: .:**********************:* *************:***:*:* :********:****:*:*::*:*:*:********:****:**.*** :**.** ****:: :* * *: ::.: : . ... .* * . .: ..: .* . .: . .. . : : *. . *.:**:: . ", "identical_positions": 150, "similar_positions": 223, "identity": "17.61%" }, { "cls_id": "homologset.agr.HGNC:16422", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P58660-1", "uniprot_id": "CAR10_MOUSE", "id": "P58660-1", "name": "Caspase recruitment domain-containing protein 10", "aln": "-------------------------------------------------MQGRADAGEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQARGRALEEERAGLEQRLREQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKERE------PDGADLLSELRAENQRLTASLQELQEGLQQEMSRPGAAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEA---GGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGWSPPAGLDPQDKSPDSMPGLGDRWSGAVVRRVLSGPGSARTEQKEPRAEGTGLEGAGLEAEAQQRTLPWNQSSTLPFLLDSKACHSFHEALDAWAKGPGAEPFYIRANFSLPERSDPHALCVKAQEILRLVDPAHKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQEKYLISSRHRSPRSNLKKRALG---LVRPKPAGGTAGDSAEQLPAEPCSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEEQCTSSAPGAPKAWPATAGLGSRIRAIQESVGKKHCLLELGARGVRELVHSEVYPIVIHVEVTEKNVREIRGLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQVPAHAWGHAEELAKVVRGRILQEQARLVWVERGSSRGGSGSSSEA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A425-1", "uniprot_id": "D4A425_RAT", "id": "D4A425-1", "name": "Caspase recruitment domain-containing protein 10", "aln": "MLGGPGGRGAGGGANDPEGTAPSRRRSRRPNTEPGAQGSCSARDSEDAAMQGRADAAEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQARGRALEEERAGLEQRLREQQAAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRGRGPPPGAEEKEKE------PDGVDLLSELRAENQRLTASLQELQEGLQQEMSRPGAAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSSLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGET---GGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGWSPSGGLDPQDKSPDSLPILGDRWSGAVVRRVLSGPGSARTEQKEPRAEGSGLEGTGLEAEVQQRTLPWNQSSTLPFLLDSKACQSFHEALDVWAKGPGAEPFYIRANFSLPERADPHALCVKAQEILRLVDPAYKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQEKYLISSRHRSPRSNLKKRALG---LVRPKPAGGTAGDSAEQLPADPCSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCSAESLSGEEQCTSSAPGAPKAWPASAGLGSRIRAIQESVG-KHCLLELGARGVRELVHSEVYPIVIHVEVTEKNVREIRSLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQVPAHAWGHAEELAKVVRGRILQEQARLVWVERGSSRGGSGSSSEA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BWT7-1", "uniprot_id": "CAR10_HUMAN", "id": "Q9BWT7-1", "name": "Caspase recruitment domain-containing protein 10", "aln": "-------------------------------------------------MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRG-CPSSSEA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * ***:*.**:***************************:*****************:*****************.******:**********:**********************************************************:**********.*************:** *************************************************************************.***********:* **..**:**************:********* *****.*******************************************:*************** *****************************************************************:********:**.****:***:.***********************************: **.***.*********************************** *************************************************************** **..* :****.**.:. ******************** * :* *.*.:****: ****.***** ***.**** *:*****:******:.***************::****:*****************.*:************.************************** * *****.**********. ******.*..****.:** :**:* ****:********************************************.******** *.********* **:.************** ****************:.*:****************:*.********************* ************** ************************** ***** . *****", "identical_positions": 921, "similar_positions": 72, "identity": "85.12%" }, { "cls_id": "homologset.agr.HGNC:16429", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIH4-1", "uniprot_id": "LIAS_RAT", "id": "Q5XIH4-1", "name": "Lipoyl synthase, mitochondrial", "aln": "MALR------CWDAARSLGSRIFG----------------------RYACS-VRALSSLP------------------DEKKKFLHNGPDLQDFVSGDLADKSTWDDYKGNLKRQKGE--RLRLPPWLKTKIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDPSEPDNTARAIAEWGLDYVVLTSVDRDDVVDGGAEHIAKTVSCLKERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVQPDVVSKTSIMLGLGETDEQVYATMKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEEVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKVSKV------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99M04-1", "uniprot_id": "LIAS_MOUSE", "id": "Q99M04-1", "name": "Lipoyl synthase, mitochondrial", "aln": "MALR------CWDTARSLGSRIFG----------------------RYAFT-VRALSSLP------------------DKKKEFLHNGPDLQDFVSGDLADKSTWDEYKGNLKRQKGE--RLRLPPWLKTKIPMGKNYNKLKNTLRNLSLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPDNTAKAIAEWGLDYVVLTSVDRDDVADGGAEHIAKTVSCLKERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLRHAKEVQPDVVSKTSIMLGLGETDEQVYATLKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEKVGNELGFLYTASGPLVRSSYKAGEFFLKNLVARRKTKASKV------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43766-1", "uniprot_id": "LIAS_HUMAN", "id": "O43766-1", "name": "Lipoyl synthase, mitochondrial", "aln": "MSLR------CGDAARTLGPRVFG----------------------RYFCSPVRPLSSLP------------------DKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGE--RLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKDL--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PHG4-1", "uniprot_id": "LIAS_DANRE", "id": "Q6PHG4-1", "name": "Lipoyl synthase, mitochondrial", "aln": "MALISR---SCGAASRYSSSHLFLPSKGAEAANVYCN---------RLSTAASTSSSSSPSPST------------HNDRKKDLREDGLNLQDFISGELSEKSKWEEYRGNLKREKGE--RLRLPPWLKTEIPIGKNYNKLKNTLRELNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARRPPPLDPDEPYNTAKAIAAWGLDYVVLTSVDRDDIPDGGAEHFAKTVSNIKERNSKILVECLTPDFRGDLAAVEKIALSGLDVYAHNVETVRELQRHVRDPRANFDQSLSVLRHAKKVKSSVLTKTSIMLGLGETDAQIQATLTELRDSGVDCLTLGQYMQPTKRHLKVEEYVTPEKFAFWEKVGQEMGFIYTASGPLVRSSYKAGEFFLKNLLEKRKTEETTATAE---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7JQW6-1", "uniprot_id": "LIAS_DROME", "id": "Q7JQW6-1", "name": "Lipoyl synthase, mitochondrial", "aln": "-MLR-------ALKTHAEAPIVVAT---------------------RAASTNAEKLEEIR----------------------ERLAKGPNFHDFVQNPDNTRNEWEQYDGKLRREKGEEQRLRLPPWLKTTIPVGKNYAKIKAQMRELKLSTVCEEARCPNIGECWGGGEHGTQTATIMLMGDTCTRGCRFCSVKTARKPPPLDVNEPVNTATAIASWGLDYIVLTSVDRDDLPDGGSEHIAETVREIKARNSNIFVECLVPDFRGNLECVKTIANSGLDVYAHNIETVEKLTPYVRDRRAHYRQTLQVLTEAKRFNPNLITKSSIMLGLGETDEEIENTLKDLREAGVDCVTLGQYMQPTNKHLKVIEYVTPEKFKHWEERGNELGFLYTASGPLVRSSYKAGEFFITSILENRKKRQNDTEVPKKQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32875-1", "uniprot_id": "LIPA_YEAST", "id": "P32875-1", "name": "Lipoyl synthase, mitochondrial", "aln": "MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAK----KLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: .. : * .. . * .: **:.. .. . ::.: :** ***. ** *.** *:* :::* * ***************** : .. ******:*************** * *. * ** *** ** ***.*:***:*****: ***::*:*:** :* : .: :** * ****:* :. :* .********:*** .* *** ** : *:* ** .** ..:::*:********.* :: *:. ** * :*:****:**.:*:** **:.**** .*:: . *:** * ************** *: .:: .*: . ", "identical_positions": 169, "similar_positions": 86, "identity": "39.49%" }, { "cls_id": "homologset.agr.HGNC:1643", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZD88-1", "uniprot_id": "D3ZD88_RAT", "id": "D3ZD88-1", "name": "B-cell receptor CD22", "aln": "MCVPCPWLLLILGHVASFR--SATGWSVEHPQTLFAWEGACIQIPCKYKVPKPRSRLDSILLFQNYTFDNTTRDFTGKVLYNNTKAS--IETELYFSQQDRVTFLGNRSNNCTLKIDPIHANDSGKLGLRLISGTDKWMEHIHLNVSERPFQPYIQLPSEIRESQRVSLTCGLNFTCFGYDISLRWSLDGSEVS-------PVTSSITSSVENVYTESKLTFQPKWTDHGKSMMCQVWHFS-QVLSERTVRLDVKYTPKLQITVNP--TEVKEGNSVTMTCQVNSSNPSLSTKKVSWFKDGSFLKEQ-----QEQEELTLHSVTKDMRGKYQCRASNNIGQGQSKEVALTVLYPPEPSKVHIYPSPAEEGQSVELICDSLASPRAT-NYTWYHNGEMVPGASHEKLQISNVSLWHAGKYSCLAENRLGCGKIEQEAELDVHYVPKAVTTVIQSVTPIREGDSVTLDCRYNSSNPEVTKYEWSPQGSGSEVTPGVLRIQKATWDSPPIKCAACNYKCSWSFPVSLNVHYAPRAVKILKVSPASEIHAGQHVLLQCDFSGSFPTEVRFFWKKNGNLVQEGRYLNFSSISPEDSGNYNCMVRNSIGETSSQAWSLQVLYAPRRLRVSISPGDSVMEGKKATLSCESDAHPPVFKYIWFDANDQDLHFSGQKLRLEPLRVQHTGSYRCQGINELGTGKSPPSTLTVYYSPETIGKRVALGLGFCLAICILAIWGMKIQKKWKHNRSQQGPQDNSSGQSFFVRNKKARRTRLTEGPQSQGCYNLAMDDTVSYAVLRFPESDTHGAGGARSPATQGPPPNDDDTVTYSVLQKRNMGDYENVSPNCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P35329-1", "uniprot_id": "CD22_MOUSE", "id": "P35329-1", "name": "B-cell receptor CD22", "aln": "MRVHYLWLLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSS-KVLSERTVRLDVKYTPKLEIKVNP--TEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSAT-NYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDTHNTGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P20273-1", "uniprot_id": "CD22_HUMAN", "id": "P20273-1", "name": "B-cell receptor CD22", "aln": "MHLLGPWLLLLVLEYLAFS--DSSKWVFEHPETLYAWEGACVWIPCTYRALDG--DLESFILFHNPEYNKNTSKFDGTRLYESTKDG------KVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMR------QAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT--VSWLKDGTSLKKQ------NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT-NYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58JBZ3-1", "uniprot_id": "A0AC58JBZ3_DANRE", "id": "A0AC58JBZ3-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------MSGLSEDTSHERSFVKSALSKFDDVTTLIPEPVKLGEFVAMVMSVSMSPPLPLIFLLMIHMVSSADWAVTYSSSHICALKDS-------------------SVIMSCTFKYPTGHQIMKVFWNKDFVEHRDELADLSEHPEYSQRLQYLGDKQQNCTVKLSLVTKK-----------------------------------------------DEHMYYFRFITDQPGGKWAGYPG----------VRLSVTDLQLES-----PERVTEGDSVRLTCRSSCNLTDTPTFIWYRNSERMIERSSE-LLLHSVRREDAGRYRCAVH---GHTLTSPEIYLNVMYPPKSVSVSISGSAVIVSGDSVTLNCSSDSNPP-----------------------------------------------------------------------------------------AEISWFKGETSVGSGRIFNISKISSGDSGEYKCRARNALGEKYSDPVTLDVQYPPMNVSVSISGSAVIMSGHSVTLSCSSDSNPP-AQISWFKG--ETLVGFG--------RIFSISKIRCRARNVHGEKYSDPVTLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .: :: .: *. : .:: : . *: : : .: .* ::* .. * . * : . . . :: :. .: .* . : . . . : : : * **.: .. : :: :*.: **: . * * * * . . **..*.: * * .. * .: **:* : : : * : : .: .** * * .. * *:* * ** *:. *.. * .**:*** * :*. * ..: * *. : . :.:..:*. *:*.*.* ..*::*:. *.. .*:* *.* .: **:* . :*.*:..**:*.**::** : **. : * . .: . *:. * * * ** ", "identical_positions": 83, "similar_positions": 136, "identity": "9.52%" }, { "cls_id": "homologset.agr.HGNC:16432", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P40807-1", "uniprot_id": "DCOR1_DROME", "id": "P40807-1", "name": "Ornithine decarboxylase 1", "aln": "---------------------MAAATPEIQFYERELNIR----RVIEECDLQRL-----------------------------DQALNICDLSSVERKLRLWQKLLPRIKPFYAVKCNDDPMVVRLLAQLGAGFDCASKNEVKLVLGFDVSPERIIFANPCRPVSHLEYAKEHQVSNGTVDNEFEVYKLHTHYPNSNLIVRFKSEAKEAQCPLGDKFGCDADVDAAALMLLAKSLELKVTGTSFHVGSGCSELQAYDRAIKKAKNLFKFGALLG--YDMDFLDIGGGFPGSDDVKFEKIAESVNTSVQRHFPDER-VHIIAEPGRFFVAAACTLVCKIHAKREIRNEAGKLDT----------VMYYLNDGVYGSFNCILYDHQVVIA-------EHYLDNAESLP-------------HLKSLIWGPSCDALDKISEDLHLPN-LNRGDLLGFRNMGAYTMPIASAFNGFEVPKTLYFQAI----------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40808-1", "uniprot_id": "DCOR2_DROME", "id": "P40808-1", "name": "Ornithine decarboxylase 2", "aln": "---------------------MVNGDLRIQYYDEELNIR----KVIEQADLEHL-----------------------------DQALNICDLSSLERKLRLWHKLMPRIEPHYAVKCNDDPVVVKFLADLGTGFDCASKNELKLVLGLGVSPERIIFAHPCRPASHLRYAKEQQVVNGTVDNEYEIYKLRKHYPDSNLIVRFKSEAKKALCPLGDKYGCDAEADAAALMLLAKALGLKVTGTSFHVGSGCSEVEAYDRAIEKAENIFKVGEMIG--HKMELLDVGGGFPGIDDEMFEEIAQSVNTSVELRFPDKR-IRIISEPGRFFVEAAYTLICKVHAKREVRSKDGKLDT----------MMYYLNDGIFGAFAGMFYYPEEVAP-------ELYLDEAESLP-------------KLKSVIWGPSCDAMDKIS-DLLLPN-LNPGDLLGFRNMGAYTMPIASPFNGFDVPETRFFKAK----------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P08432-1", "uniprot_id": "DCOR_YEAST", "id": "P08432-1", "name": "Ornithine decarboxylase", "aln": "MSSTQVGNALSSSTTTLVDLSNSTVTQKKQYYKDGETLHNLLLELKNNQDLELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGEVKRLFNNWVKELPRIKPFYAVKCNPDTKVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYANPCKVASFIRYAASKNVMKSTFDNVEELHKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEMEN-VDVLLKAIKELGLNLAGVSFHVGSGASDFTSLYKAVRDARTVFDKAANEYGLPPLKILDVGGGFQ---FESFKESTAVLRLALEEFFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENE---------------AMIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPTCDGLDCIAKEYYMKHDVIVGDWFYFPALGAYTSSAATQFNGFEQTADIVYIDSELD-------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "O14977-1", "uniprot_id": "AZIN1_HUMAN", "id": "O14977-1", "name": "Antizyme inhibitor 1", "aln": "---------------------MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHT--------------------------LTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAK-ELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIG--FTMNMLDIGGGFTG-TEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGS-DEPAFMYYMNDGVYGSFASK-LSEDLNTIP------EVHKK-YKEDEP------------LFTSSLWGPSCDELDQIVESCLLPE-LNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGITSDSMMKNFFFVPSCIQLSQE-DSFSAEA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q63764-1", "uniprot_id": "AZIN1_RAT", "id": "Q63764-1", "name": "Antizyme inhibitor 1", "aln": "---------------------MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHT--------------------------LTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYMVKCNSTPAVLEILAALGTGFACSTKNEMALVQELGVSPENIIYTSPCKQASQIKYAAKVGVNIMTCDNEVELKKIARNHPNAKVLLHIATEDNIGGEDGNMKFGTTLKNCRHLLECAK-ELDVQIIGVKFHISSACKEYQVYVHALSDARCVFDMAGEFG--FTMNMLDIGGGFTG-TEIQLEEVNHVISPLLDIYFPEGSGIQIISEPGSYYVSSAFTLAVNIIAKKVVENDKLSSGVEKNGS-DEPAFVYYMNDGVYGSFASK-LSEDLNTVP------EVHKK-YKEDEP------------LFTSSLWGPSCDELDQIVESCLLPE-LSVGDWLIFDNMGADSLHGPSAFSDTQRPAIYFMMSLSDWYEMQDAGITSDAMMKNFFFAPSCIQLSQE-DNFSTEA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M1N598-1", "uniprot_id": "A0A8M1N598_DANRE", "id": "A0A8M1N598-1", "name": "", "aln": "-------------------MSMKGSLDELHYSVELLEGSAALRDVIDKHIYDQT--------------------------FAQKSAFFAADLGVIVQQQARWRNKMDQIRPFYTVKSNSSPVVVELLASLGTGFICSNKHELDLVKGFGVSSQDIILGGTCKQLSHIKYAAKHNIPLLVCDNEAEMRKIARCHPKAKVLLLLTSESCCEKEEMAIPFGSTLKDCRRLLECAAGELNLQVTGVKFNIPSCCQEVEKFSRAVSEARCVFDMGEELG--FEMNILDIGGGFDG-SEEQLDKVNQMLKPMLDMYFPRSTGLSIIAEPGAYYVSSAFTLAVNIIDKKTVARDCSAQPHDALSANDEPEFLYHINDGVYGSFASKLLCEDSIATP------LAHKH-VSADEP------------LFSSSLWGPSEDDLDLVMERCLLPE-LSVGDWLLFRNAGASALGSAFSHGDQHKPPVFYSITEYDWQEIHNSGVTVDVRMKNFSLVPCCLQPNMSGASISTPA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q801V3-1", "uniprot_id": "Q801V3_DANRE", "id": "Q801V3-1", "name": "", "aln": "---------------------MKGFVDAPNYFIELLEGGTTLENVIDNHIYEQN--------------------------LAEKNAFVVADLGALMRQHVVWKTTMPLVRPFYPVSCNSSPVVIELLSALGVGFVCANKAETTLVLSHDVPPENIILSGVCKQLSLIKHAAKTGINFLLCENEAELRKIARAHPEAKLLLQVSTEAQI--EEASVTIGCSLKGCRHLLELAK-ELNVSVAGVTFQVPASCKDPQAYTHALSDARCIFDMGKELG--FDMNILDIGGGFSG-SEFQLKQVHSVIRPLLEAYFPSESGVSIIAEPGNFFVFSCFTLAVNVIGKKAAYRNLHTSTHDKLTSSDAPEFVYYMNDGVYGSFMGR-LFGNIISTP------SVHKMSLTLDEP------------VFSSSLWGPSCDPLDQVVERCLLPE-LAVGDWLVFSNMGASGQEGPATFSDTDQPPVYYTISTDDWFEMQEAGISLDDTMKNLSLVQFGL-------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0ABJ3HKJ7-1", "uniprot_id": "A0ABJ3HKJ7_MOUSE", "id": "A0ABJ3HKJ7-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPPKKRRRF-----TRLFG-P----------LSHGELSDR----------------------VYNYPEG-LGEVLYR------------------EQFDFNAEPP------------------WEPS---------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * ::. * * .: : :* * . * *: ", "identical_positions": 7, "similar_positions": 10, "identity": "1.34%" }, { "cls_id": "homologset.agr.HGNC:16435", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D8V0-1", "uniprot_id": "SPP_MOUSE", "id": "Q9D8V0-1", "name": "Signal peptide peptidase", "aln": "------------------------------------------MDSAVSDPHNGSAE-AGTPANGTT---RPPSTPEGIALAYGSLLLMALLPIFFGALRSVR------------------------------------CARGKSSS-DMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSH---TISPFMNKFFP---------ANFPNRQYQLLFTQGSG---------------------------------------------------ENKEEIINYEFDTKDLVCLGLSSVVGVWYLLR-KHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALLLRFDISLKKNTH--------------TYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVAEMF--SYEESNPKDP-AAETESKEESTEASASKRLE-KKEK---------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZP98-1", "uniprot_id": "D3ZP98_RAT", "id": "D3ZP98-1", "name": "", "aln": "------------------------------------------MDSALSDPHNGSSE-AGTPANGTT---RPPSTPEGIALAYGSLLLMALLPIFFGALRSVR------------------------------------CARGKSSS-DMPETITSRDAARFPIIASCTLLGLYLFFKLFSQEYINLLLSMYFFVLGILALSH---TISPFMNKFFP---------ANFPNRQYQLLFTQGSG---------------------------------------------------ENKEEIINYEFDTKDLVCLGLSSVVGVWYLLR-KHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALLLRFDISLKKNTH--------------TYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALVKGEVAEMF--SYEESNPKDP-AAVTESKEESTEASASKRLE-KKEK---------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TCT9-1", "uniprot_id": "SPP_HUMAN", "id": "Q8TCT9-1", "name": "Signal peptide peptidase", "aln": "------------------------------------------MDSALSDPHNGSAE-AGGPTNSTT---RPPSTPEGIALAYGSLLLMALLPIFFGALRSVR------------------------------------CARGKNAS-DMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSH---TISPFMNKFFP---------ASFPNRQYQLLFTQGSG---------------------------------------------------ENKEEIINYEFDTKDLVCLGLSSIVGVWYLLR-KHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTH--------------TYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMF--SYEESNPKDP-AAVTESKE-GTEASASKGLE-KKEK---------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VPQ7-1", "uniprot_id": "SPP_DROME", "id": "Q9VPQ7-1", "name": "Signal peptide peptidase", "aln": "--------------------------------------MAEEVIGTVKEVLKGIIENVNAPKNESAPGEKKPSTPEGMAVAYSSLVVMAMLPIIFGSIRSVK------------------------------------LHKLKKSTGEKADTMTKKDAMYFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAH---LLSPVINSLMP---------AAVPKVPFHILFTKGEG---------------------------------------------------KHKEDIVNYKFSTHDIVCLVISSAIGVWYLLK-KHWIANNLFGLAFAINGVEMLHLNNFVTGVILLSGLFFYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLIENGLNASNFAMLGLGDIVIPGIFIALLLRFDDSKKRKTR--------------IYFYSTLIAYFLGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLF--AYEDHPEEKPEKKEKKEKDEGVSSSGSKKKESKKGK---------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34248-1", "uniprot_id": "SPP_YEAST", "id": "P34248-1", "name": "Intramembrane protease YPF1", "aln": "MDKYLNSFVDHLSEWSSRAFRNNSSSANQSASNKELEQVFEQINAIVENHNNKLTTAFDKISYRVAHKITHLVESHSLVFNYATLVLIASALVVIGSFTSISSIPFTALPPTREHSLFDPTDFDVDHDCHVIYRENDEDKKKKKKSKRFFDMMDEKHAIILPLTSGCTLLALYFVIKKLHLNWLKYVVKILNFNITLLNIPAGTFVYSYFLNSLFRNLSHLASWNPLVVLPRYRVTIADDNEDLNKIGGFVTNLNYKDGLTNSVVHKKTLDEIEKDHWMKHFYRRELVEPKDIKSKRQISNMYLNSALIVSFVLSIVSTVYFYLSPNDWLISNAVSMNMAIWSIAQLKLKNLKSGALILIALFFYDICFVFGTDVMVTVATNLDIPVKLSLPVKFNTAQNNFN-FSILGLGDIALPGMFIAMCYKYDIWKWHLDHDDTEFHFLNWSYVGKYFITAMVSYVASLVSAMVSLSIFNTAQPALLYIVPSLLISTILVACWNKDFKQFWNFQYDTIEVDKSLKKAIEKKENSITYSTFILSEYYNDADKYALLGDDVNENFDDDEEFVQEEDLSDSSEEELSEEDLLDDESS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . :.: : . : ...:.. *.:*:::* :.:*:: *: : *. : : : .:.* :*: :..:*:.**:.:* : :: ::. * : :: :. * .:*.:: . . ::: ::... : *.:* * :.: :*.: :* *:: * :.*: .* ..: ::: .: *:*:*. :* ::* .**:**: :****:******..:: *:** :* .: : . *::*****:.:**:***: ::* : : ** ::: :*. .* ::. : :*: *******:**: : .:*** . :. :: *: ... :.*: . * * : ", "identical_positions": 80, "similar_positions": 157, "identity": "13.61%" }, { "cls_id": "homologset.agr.HGNC:16437", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q60928-1", "uniprot_id": "GGT1_MOUSE", "id": "Q60928-1", "name": "Glutathione hydrolase 1 proenzyme", "aln": "--------------------------------------------MKNRFLVLGLVAVVLVFVIIGLCIWLP--------------------YTSGKPDHVYSRA----AVATDAKRCSEIGR---DILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEVINAREVAP---RLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHG--RLPWARLFQPSIQLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCR--QGKVLQEGETVT-MPKLADTLQILAQEGAKAFYN--GSLTAQIVKDIQEAGGIMTVEDLN--------NYRAELIEHPMSIGLGDATLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFY-------LQDDGGTAHLSAVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSP-ANFIKPGKQPLSSMCPSIILDKD-GQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKD--IDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPAGY-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BX51-1", "uniprot_id": "GGTL1_HUMAN", "id": "Q9BX51-1", "name": "Glutathione hydrolase light chain 1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSEFFSAQLRAQISDDTTHPISYYKPEFY-------MPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILLNNEMDDFSSTSITNEFGVPPSP-ANFIQPGKQPLSSMCPTIMVGQD-GQVRMVVGAAGGTQITMATALAIIYNLWFGYDVKWAVEEPRLHNQLLPNVTTVERN--IDQEVTAALETRHHHTQITSTFIAVVQAIVRMAGGWAAASDSRKGGEPAGY-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VYR2-1", "uniprot_id": "Q9VYR2_DROME", "id": "Q9VYR2-1", "name": "", "aln": "--------------------------------------------MYIRIGLNSLISVVIVILVAVYIYRYPDGNAGKKKASRRPPNPEDPLPPSNSPLHRFSRA----AICSDSDVCSQLAK---KVLENGGSAVDGALAALICNGLIGMQSMGIGGGMVMNVYVAKENKSYSILAREMAPLALRADNFSSFRDEQDFKRSGWSIAVPAELAGYAVAHQRFG--RLKWKDLVLPTLELCRRGYRLYKHQYDALILNQDMIRADSGLRRMFIDPDTGRFWPLGHLIRPAAQLCNTYDRLANEGPLSFYR--GSIADDLLADLKDAGSAITKEDLN--------QAHAKLSS-AIVMPLDEYDLHLTPPPGSGHVLGFIMNILKEFRAEFSRAGTMSPR--QIHLMVEAMKFGFVKRWQLDES-------ASEELLSNLTSHELAKSVARQINHTHTFNRPEFYGASPGIQIRDEHGTAHTSVLHGN-DAVSVTSSINFYFGSGRTGRRTGVIFNNAMSDFSIEQLKNYFDLPFVPGTNGVAPAARPMSSMCPVIVTERATGNVRLVVGAAGGTKIISALSPLLVRILWQEASIKAAIDASRIHHQMLPNVLLYEYG--LRQSYVDSLAERGHRCERYENRGSVICGIAQANDTIWVNSDFRKPGGVSGF-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q05902-1", "uniprot_id": "ECM38_YEAST", "id": "Q05902-1", "name": "Glutathione hydrolase proenzyme", "aln": "MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAP--MDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQ----EGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSI-YNFPEPGKRPLSSTAPTIVLSEL-GIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFP-KSVVNAIRNVRGEWHAVSDYWRKRGISSVY", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : : : : . :: : : **** * : . .**: *::**: *** . :*:::*: *.**: . * * :. * *. :*:** .* *: . * :****:**::* : :: * : :: .*:*:*:**: * : : * : : :*: .: . . . ** : :. ", "identical_positions": 46, "similar_positions": 64, "identity": "6.88%" }, { "cls_id": "homologset.agr.HGNC:16438", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AJN7-1", "uniprot_id": "S4A11_MOUSE", "id": "A2AJN7-1", "name": "Solute carrier family 4 member 11", "aln": "MSQNE-----------HCQDSGEYFSAGTQGYFKN------NMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAP----------MESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMM-----MPRAAGHSMSSLHTHRHPQ--------------PPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGH---HYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHS----------LSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZVP9-1", "uniprot_id": "D3ZVP9_RAT", "id": "D3ZVP9-1", "name": "Solute carrier family 4 member 11", "aln": "MSQNE-----------HCQDSGEYFSAATLGYFKN------DTDDNPDVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDIEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFAQDPNHAEPDCDLDLLMAKLFTDAGGP----------MESKVHLLSDTIQGVTATVRGLQYEQSWLCIVCTMKSLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMM-----MPRAAGHSMSSLHTHRHPR--------------PPKCKDFFPFGKGIWVDIMRRFPVYPLDFTDGIIGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGH---HYHTKRTSSLASLLGISRSPNTSLHTALNTSFLASPIEMTTASSPISTHSNQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLISSYGFQEIEMSKFRYNPSESLFEVAQIHS----------LSFKAISSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVNVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NBS3-3", "uniprot_id": "S4A11_HUMAN", "id": "Q8NBS3-3", "name": "Solute carrier family 4 member 11", "aln": "MAAATR-------RVFHLQPCENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLFTDAGAP----------MRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPE--------------PPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSA-----THSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQS----------LSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP--------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T691-1", "uniprot_id": "A0AB32T691_DANRE", "id": "A0AB32T691-1", "name": "", "aln": "MKTDKDGKDMRGVTVNRFAEEAPSSGMAKNGYFYQ------EMEQREREEHEEGSEEREEGQDSPIPSGDDIHLYG-----SQTHQGGPETDVHGCVLLNTSRRYVKLMNFEEEVRAHRDLDGFLERASILLHEDEASLDDVLKTMLRHVSQDPHTAEPGCNFEEIMSSLFTDAGSQEVNDRSANFIFYDNVHLLSETLQCVTATATGIQYQQSWLCILCNVKNLQRRHVCISRLDRPQNWGENCAEVRYVILILAPSKMKSTKTAMELGRTFASMFSDISFRQKLLESKTQEEFKEALVIQRYHLTAAKRKTTAVEGEETDPHSQKPLKSAESVFSHLVSLSLLCRGPCCRDFFRVGRGIYEDLCRRLPLYPSDFTDGLVGNNKALVKFMTTSIFLYIAVLLPAIAFGSLNDESTRGEIDVQKTIIGQSIGGIIYSLCAGSPLVIPLTTAPIAIFISVIRGICDDYELDFAAFYACIGLWNSLFLIMGGVFNLSLLVKLFKRSIEEVIALFISIAFVADAVKGTVKIFHDNYHAP------TLANGSAAELNRISG----SVHLGELNQTEAGPVSLPES----FILCTRARPLLCLLLMMGTLWVGYTLYQFRRSPFLHVKMREILSDCALPISVLVFSYVGSYVFNDIALPVFNFHEG-PVFQVAPLDK----------LTGASVLSAMGLGFLLFLLIFIDQNIVVSLTNAPENRLLKGTAYHWDLTLSGLINILMSVLGLPWMHAAFPHSTLHVRQLAIVEERVEGGHLYETIVSVKETRVTSLVANILIGVSVFLLPVPLQWIPKPVLYGLFLYIALTSIEGNQMCDRMALLLKEQTSYPPTHYIRKVPQRKIHYFTFLQMVQLLFLCAFGMYPLPYMKMIFPLLMFILIPIRNCLLPRIIEAKYLDIMDAQRM---------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53838-1", "uniprot_id": "BOR1_YEAST", "id": "P53838-1", "name": "Boron transporter 1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNESTRVTVSRG---------------------------CTASDECAQALERTNDELDRESSVSESRSDEESHEKLSRRR--------------------------------------------------FPTLGIGIWLDLKDRIPYYKSDWVDAFN------YRVIPSIVDTYFNNLLPAIAFAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISIFNYTVYEIIKPLNTSYFGFMFWICMWSMIFHLVLAFTNAVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFSAKSGEK-----------------------------------------------------SVQDGFASVVVALVMTAFGLFFKLFHYYPLFSHRIRTFISDYSTALSVLFWSSFTHFGGYLHDVKFKKLPITKAFFPTSKVNRPQNTWLAYEPIPVKDVFIALPFGIFLTILFYFDHNVSSLMAQRHQYKLKKPSSFHYDFALLGLTTCISGVLGIPAPNGLIPQAPLHTETLLVRDSNQK------VISCVEQRFTNTFQGLMILGTMTRPLLVCLGEIPQAVLSGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMKVSKKSMLIFLSFSLTGFAGEFAITN-TIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQKFTIKNLLLENIRDAKFCDKHED", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :* :** .:: * .::: .:: ...: :::::** :* * :* * .* ** *: *:* * *:.*.: : :.: : *: ***:***.. : * . .*::.: ..::.*:::.: .*.** * .*.*:::: .: * . : .: .* :*. :* : .. * ::. .. :::.***.:.:: ..:: .: * . .::: : .* : *: * : :* :** : .::** :* . . : . . * : :. :. : *: :*::* :*:::::*: :.: : :* * :::*:*: * .: . .::*:* :. *::.**.. * : :.. : .* *:: .:: . :::* * . * **:.** ***: :.:..: *.: .*:.:*:.: . * : :*.::.: * :.: : *: .:. : : : *:: ::.: : * * ** *:: ", "identical_positions": 95, "similar_positions": 223, "identity": "10.1%" }, { "cls_id": "homologset.agr.HGNC:16441", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80ZQ0-1", "uniprot_id": "SACA4_MOUSE", "id": "Q80ZQ0-1", "name": "Sperm acrosome membrane-associated protein 4", "aln": "MVLGWPLLLVLVLCPGVTGIKDCVFCELTDSARCPGTHMRCGDDEDCFTGHGVAQGVGPIINKGCVHSTSCGREEPISYMGLTYSLTTTCCSGHLCNKG-TGLSTGAT-SLSLGLQLLLGLLLLLQYWL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZT54-1", "uniprot_id": "D3ZT54_RAT", "id": "D3ZT54-1", "name": "", "aln": "MVFGWLLLLVLVLCPGGTGIKDCVFCELTDSARCPGTHMRCGDDEDCFIGHGVAQGVGPIINKGCVHSTNCGREEPISYMGLTYSLTTTCCSGHLCNGG-AGLATGAT-SLSLGLQLLRGLLLLLQYWP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TDM5-1", "uniprot_id": "SACA4_HUMAN", "id": "Q8TDM5-1", "name": "Sperm acrosome membrane-associated protein 4", "aln": "MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEEPVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL-----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: * ****:.* ** **:*********** :****:*:******** ***** *.**:*****:::*.** ***:** *:******.**:*:*** . :. :.*** **:*** :* ** ", "identical_positions": 81, "similar_positions": 25, "identity": "62.79%" }, { "cls_id": "homologset.agr.HGNC:16442", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESG6-1", "uniprot_id": "P2Y14_MOUSE", "id": "Q9ESG6-1", "name": "P2Y purinoceptor 14", "aln": "MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O35881-1", "uniprot_id": "P2Y14_RAT", "id": "O35881-1", "name": "P2Y purinoceptor 14", "aln": "MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPIS----ISSYASRLEKS-----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15391-1", "uniprot_id": "P2Y14_HUMAN", "id": "Q15391-1", "name": "P2Y purinoceptor 14", "aln": "MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *:*:*:**.:.*: * ***:****:** :***:*:****:**********************:***:*.******:*.********:**** *****:*********.***************** .*::***.***:***:**:***************.*::**:*:*:***.************:**:***:***** *** ***:********* :** ***:**********:.*..**.***:***********.****::** * * ***************** ..: . * *. ", "identical_positions": 232, "similar_positions": 55, "identity": "68.64%" }, { "cls_id": "homologset.agr.HGNC:16443", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0KWS3-1", "uniprot_id": "A0ABK0KWS3_RAT", "id": "A0ABK0KWS3-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "aln": "MPQGAAALPACRCRPCGPGAHLLGRRCPRLCVCSKRVKVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCMVTSVTPAPD-WAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVRCITEEEDSFDFIGG-------------FDSYG--------------------YQGPQKTS------HLQLQP--MYMSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q4PNJ2-1", "uniprot_id": "NKAI2_MOUSE", "id": "Q4PNJ2-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2", "aln": "-------MGYCSG------------RCTLIFICGMQL-VCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYVTGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCMVTSVTPAPD-WAPEDHRYITVSGCFLDYQYIEVAHSSLQIVLALAGFIYACYVVRCITEEEDSFDFIGG-------------FDSYG--------------------YQGPQKTS------HLQLQP--MYMSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VXU1-1", "uniprot_id": "NKAI2_HUMAN", "id": "Q5VXU1-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2", "aln": "-------MGYCSG------------RCTLIFICGMQL-VCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSVTPAPD-WAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGG-------------FDSYG--------------------YQGPQKTS------HLQLQP--MYMSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A8U9-1", "uniprot_id": "A0AB13A8U9_DANRE", "id": "A0AB13A8U9-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "aln": "-------MGCCSG------------RCTLAFICGMQL-ISILERQIFDFLGYQWAPILTNFIHIITVILGLFGTVQFRPRYVTGYAVWLVLWVAWNVFIICFYLEVGDLSKDTDLIMTFNISMHRSWWMENGPGCRVTPVTPPPS-WAPEDHRYISIAGCLLEYQFVEVAHSSLQIILALAGFIYACYVVKLISEEEDSFDFIGG-------------FDSYG--------------------YQGPQKTS------HLQLQP--MYMSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A6MHQ4-1", "uniprot_id": "NKAIN_DROME", "id": "A6MHQ4-1", "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "aln": "-------MGSCSCTR----------RHFLLSICFLQV-ITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFYLNVGQLNRDSDLLNLG--TGSVSWFEANGYGCKPTYNMAADDTFRPQ--RPERVEGCLLDYPLVEITHSGVQCALALLGILGAILISCIFLDEDDRFDFMNGDAKSPQHTVVHPMYVSYTSIPTTSASATMQSNKHLQLQHQQPQQNSLKLYHHQQQQQPKLHHFNKNYQLSGSNNNTLNNNLHQRAPALLPPNTTNNRSASFQTQSHPSNNHVTQRTGGEGSNCSSLRRHRQHHSKALVSPSPMSPQTTPSLSYASLQNSSPYLAGNSLSNSNYSIFQSPDSLQGSSHFARIHHKPKPPKSDYPVSGEFNPGGNISSPVRPLDRLSRSLEDDEDNFSLQKFAPGEHGVTYVPFQSPTPNSLFLGENNNSQPHLVFHTNSRSSPNNNAYPYDQSGLPSSLRMGSNSNARRPTHIPLPTVPMHNCQEVENDEDADGESEQDHDQMLTPPPPPLVRPHIHQRLGQAPYLDLSPEVAERYAIPSKLGPSLPIQVPLPVPHGSPMVRRSNRRPRPSNPVNFCDQIRATPPGYVVRAQSDDRLMEQVEADAAPHVNRRSGRGGSGQKTRPRSFCNSIVGVQG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * * :* :: : ::***:****** *****.**.**: :*:*::*: ::* :*: * :* .**: **.*:*****:.*:*.:::**: : **: ** ** * .. . : *: * : **:*:* :*::**.:* *** *:: * : : :*:* ***:.* : ** :* **:.* : * ** ::.* ", "identical_positions": 80, "similar_positions": 64, "identity": "11.76%" }, { "cls_id": "homologset.agr.HGNC:16445", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99L04-1", "uniprot_id": "DHRS1_MOUSE", "id": "Q99L04-1", "name": "Dehydrogenase/reductase SDR family member 1", "aln": "MVAPMKGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRATAQEAQSLGGRCVPVVCDSSQESEVKSLFEQVDREQKGRLDVLVNNAYAGVQAILNTTNKSFWEVPASIWDDINNVGLRGHYLCSVYGARLMVPAGKGLIVIVSSPGGLQHMFNVPYGVGKAACDRLAADCAHELRRHGVSYVSLWPGLVQTEMVKEFMAKEDTPEDPLFKKMKPDFSSAESPEMSGKCVVALATDPNILNLSGKVLPSCDLARRYGLKDIDGRPVKDYFSLGYALSQVSSLGWLNSFLPGFLRVPKWVVTLYNSKF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6AXY8-1", "uniprot_id": "Q6AXY8_RAT", "id": "Q6AXY8-1", "name": "Dehydrogenase/reductase SDR family member 1", "aln": "MIMTMKGQVCVVTGASRGIGRGIALQLCQAGATVYITGRHLDTLRATAQEAQSLGGRCVPVVCDSSQESEVKSLFEQVDREQQGRLDVLVNNAYAGVQAILNTTTKSFWEAPASLWDDINNVGLRGHYLCSVYGARLMVPAGKGLIVVVSSPGGLQHMFNVPYGVGKAACDKLAADCAHELRRHGVSYVSLWPGLVQTEMVKEYVAKEEQPEDPLFKKMKSVLSSAETTEMSGKCVVALATDPNILSLSGKVLPSCDLARRYGLKDVDGRPVQDYFSLGYALSQVSSLRWLASYLPGFLRVPKWIVTLYTSKF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96LJ7-1", "uniprot_id": "DHRS1_HUMAN", "id": "Q96LJ7-1", "name": "Dehydrogenase/reductase SDR family member 1", "aln": "MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLRVPKWIIALYTSKF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* .*:**********************:****************..*********:**************:**********:***************:**** .*:***.***:*************:*************:****::****.**:**************:*************** ******:****::**.:***: :**::*::*. :****:.*:***************.*****************:*:*****:**:**. .**:**.* ** *:**.*******:::**.***", "identical_positions": 252, "similar_positions": 51, "identity": "80.51%" }, { "cls_id": "homologset.agr.HGNC:16446", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R6R8-1", "uniprot_id": "M0R6R8_RAT", "id": "M0R6R8-1", "name": "Caspase recruitment domain-containing protein 14", "aln": "MAELCRMDSTLTALDEELLWDMLESHRCRIVQSICPSRLTPYLRQAKVLGQLDEEEILHSSRFTNSAMRVGHLLDLLKARGKNGAIAFLESLKFHNPDVYTLVTGLQSDIDFSTFSGLMETSKLTECLAGAISSLQEELAQEKAQKEVLLRRCQQLKERLGLAEAHAEGLRQLEVDHGRMKREVSTHFHEVLKLKDEMLNLSLHYSNALREKELAATRCHSLQEELYLVKQELQRASLVSSCERESLERSLKMASDLEPEGEELNRLKEENEKLRSMTFSLTGFELRILLSQYPGMIDLHHQVEKDILEQSLDEARESKQELVDRIHSLRERAVAAERQQKQYWEEKEQTLLQFRKTQVDCELYKEKMTMLQGQVAELQKERDQAYTARDRAQMEISQRLVEKDALRRRVFELTEQVCELRTQLRRLQAEAPGGPKQEAGNREICLRGKQRLVRMHAVCPPDDSDCSFLSSTESRLWWDLNSTSSREQMDSFRSSSPMPPSQQSLYKR--VAEDFLEDPESLS----LPEVLEVRLQGATLDDTDTDLEFEMLDGADLSQTEDSLQGSSRS-LNVSESSVPVRRRP-ARKILSQVTVLAFQGDALLEQIGVIGGNLTGIFIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSVKINTEGYKNLIQDLDAKVVTSGDSFYIRVNMAMQRRGEGELHAHCNDILHVTDTMFQGRSCWHAHHVNPYTMKDMEP-GTIPNYSQAQQQLLALIQDMTQRCTVAR--KPP-GGPQKLVRIVSVDKAAVSPLTSSFDQGQEDSGKEEGGPSVCFWPENCFTLAPYTLVHPHRPAWPRPVLFVPRVIGKILGKKLCLLQGFKQCSAEYLSQEEYVTWSQRGDIIQEGESIGDHHCVTRHAVQSLMNTSTHALLDVRLDSVRVLHKMDIFPIIIHVSVNEKTAKKLRKGLHRLGSSEEQFLEVARQEEGELDRVPCLYSSLAPDNWSDLDSLLNCVRLAIADEQKKVVWTEGPC-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99KF0-1", "uniprot_id": "CAR14_MOUSE", "id": "Q99KF0-1", "name": "Caspase recruitment domain-containing protein 14", "aln": "MAELCRMDSTLTALDEEMLWDMLESHRCRIVQSICPSRLTPYLRQAKVLGQLDEEEILHSSRFTNSAMRVGHLLDLLKARGKNGAIAFLESLKFHNPDVYTLVTGLQSDIDFSTFSGLMETSKLTECLAGAISSLQEELAQEKAQKEVLLRRCQQLKERLGLAEAHAEGLRQLEVDHSRMKREVSTHFHEVLKLKDEMLNLSLHYSNALREKELAATRCHSLQEELYLVKQELQRASLVSSCERESRERSLKMASNLEPQGEELNRLKEENEKLRSMTFSL---------------------VEKDILEQSLDEARESKQELVDRIHSLRERAVAAERQQKQYWEEKEQTLLQFRKTQVDCELYKEKMTMLQGQVAELQKERDQAYTARDRAQMEISQRLVEKDALRRRVFELTEQVCELRTQLRRLQAEAPGGPKQEAGARELCLRGKQRLVRMHAVCPPDDSDCSLLSSTESRLWWDLNSTSSREQMDSFRSSSPMPPSQQSLYKR--VAEDFLEDPESLS----FPEVLEMRLQGATVDDTDTDLEFEMIDGADLSQTEDSLQGSSRS-LNVSESSVPVRRRP-ARKILSQVTVLAFQGDALLEQIGVIGGNLTGIFIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSVKINTEGYKNLIQDLDAKVVTSGDSFYIRVNLAMQRGGDGELQTHCNDILHVTDTMFQGRSCWHAHHVNPYTMKDMEP-GTIPNYSQAQQQLLALIQDMTQRCTVPR--KPP-GGPQKLVRIVSVDKAAVSPLTSSFDQSQWDSGKEEGGPSVCFWSESCFTLAPYTLVHPHRPARPRPVLFVPRLVGRILGKKLCLLQGFKQCSAEYLSQEEYATWSQRGDIIQEGESIGDHHWITRHAVESLMNMSTHALLDVRLDSVRVLHRMDMFPIIIHVSVNEKTAKKLRKGLHRLGSSEEQFLEVARQEEGELDRVPCLYSSLAPDSWSDLDSLLSCVRLAIADEQKKVVWTESPC-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BXL6-1", "uniprot_id": "CAR14_HUMAN", "id": "Q9BXL6-1", "name": "Caspase recruitment domain-containing protein 14", "aln": "MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSL---------------------AEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKR--VAEDFGEEPWSFSSCLEIPEGDPGALPGAKAG--DPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRP-ARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTR--KPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEG-SSTCFWAESCLTLVPYTLVRPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q0C3-1", "uniprot_id": "A0A8M9Q0C3_DANRE", "id": "A0A8M9Q0C3-1", "name": "Caspase recruitment domain-containing protein 14", "aln": "MAESVLDTPDLKDLQEEELWGLINDNRHAICLGIRPCVLIPYLRQARVLTDLDEDEILNCLTLINRSMRTSHMLDLLRIQGRNGAMALLESLMIHYPTLYTQITGRQPSIEPSRFSGLIKYTELTEYLVHAVSSMQKELQVTQHESSRLRAQCCELEGKLGQAEQNNQEFFQIQREHARLHNHLDGLNRELLKLKDEKCDLYVRYTTALEEKSANVIRNRDLQLEIYQLQCDLRKAQKQTEFQR---QHSVKNLSDTQKLKDELSAVR--AKLLETETFSP---------------------VKQDILAHDLKEIETRRSELAEEVNRINEEKEQLQQEKEELLEEKNSLALEVAKLTVDCEMYKHRSMLFQSQLEDVQAERDKAYLSRDEAQAQIARSLAEKDTLRSQLMELQEKLFTMNACSTQRERREKSRDRKFSCESSPPSSPTLRRQ-----------RCDLKTIHPKCFISYDASEFSDEHISSIISNQVEPPCSESLRRRDLHFSSRSDTEDNFS----IQDLADDCFTDDDYVVIAKGHCLEESVSSSSISSPMSKRSHPDSVSRVSAPPFLMRSRPQALRITGRILTIFFQGETLLNQIQIIGGNKTGVFVHHVTKESSAHNSGISPGTQILQLKYERKRRAVQMVLEDTTMEEALWALGQVQGPCHITLRPNQDAYENLLQQLKNDEVMSGDSFYVRVNMTLPGDVAGNLSVKCNDIIHITNTYHTNDGFWWGSHVHPCHLEDLKS-GALPNYYRAQRLLIRAIEDMTYSRKTHRKGRTAADEKQRVVRIVSTSQQRRNPLWVSVEDDNSKSQDNDG-----CLPSRCLTLMPFTLVTPRFPPICRPVLLLPTILGRVLHKRLAEQEGYQLCEPEQLMTSEHGMQMQKGEILEECDS-KTHLCYTLQGVEKIMKRGTHCVLPFGLDCVCRLHRAEIFPIIVYIISTERSLRRLRHKLRQNSVTESQVLECSCSEEPLLDKLPCLYRSIPPESWHDTATLVDTLKTVVTEEQNKIVWVESDPW", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.* . *. *:** ** :::.:* * * *. * ******:** :***:*:*:. : * :**..*:****: :*:***:*:**** :* * :** :** *..:: * ****:: ::*** *. *:.*:*:** : :.. * :* :*: :** ** . : : *:: :*.*::..:. :*:*:**** .* ::*:.**.**. . * :.** *:* :: :*::*. :. : ::*:: *: : :**. :: : *.: *** .::*** :.*.* . :.**.:.:: :.*. :::::: ***:. *:. * : *::*:.: :*.*: ::* ***:** :** ** :*:: *.***:** :::** ::: :.: : : . . :: : . . * *.: : . : : * * :.*: *.. **..:** :* .. : .:* : : : . * :. . * : . . ** . . :* ** * :* .:: : ***::**:** :**** **:*:*:** *:*.: .: *****: :.*: .. .: .**:**:*:*: * :*:* * :::: * :.*:.*:*:*. . . ******:***::: *:* .:**:::*:*:* . . . * . :*:. ::* . *::*** :**: *: *:*** .. * :.. . *::***** .: .** *.: .: .. :* .. *:** *:*** *: *. ****::* :*::* ::*. :*:: * .* * .*: *:*:*::* : : * :.*:.:*: .**.:* . **.* **: ::***:::: .*: ::*:: *:: . :*.*.** : .** **: **** *:.*:.* * *:. :: .:::**:*:**.* ", "identical_positions": 305, "similar_positions": 360, "identity": "29.53%" }, { "cls_id": "homologset.agr.HGNC:16447", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9Q459-1", "uniprot_id": "E9Q459_MOUSE", "id": "E9Q459-1", "name": "", "aln": "MAVTQGQLSFSDVAIEFSQEEWECLDHAQRALHRDVMLENYSNLLSLGVTLPNLNAMSKLEQYKGPWTVESEAIRTRKSNGKEYIRAMS---------------------------------AENINGNEAKSISSGSS----------------ILSSDKILASG----DK-------------------------------------------------APVVHEYDVYSSLRIK-------------GQKAT----------------------------IKGKPYQCKECDKVFSYTSSLAYHRQIHTGEKLYKCLECGKAFFRRSYLLVHERHHTGAKPYKCNECGKVFSQNSHLKSHRRIHTGEKPFKCNHCGKAFSVRSNLTHHQVIHTGDKPYKCNECGKVFSQTSSLTIHRRTHTGEKPYRCNECGKVFSSHSNLNTHQAIHTGEKPYKCSECGKVFTQNSHLANHWRIHTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPYKCNECGKVFTQNSHLASHRGVHSGEKPYKCEECGKLFSQTSNLARHWRVHTGEKPYKCSECGKAFSVRSSLIAHQVIHTGEKPYKCTECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAFNSHSNLNTHQVIHTGQKPYKCMQCGKVFTQNSHLAN----------------------------HQRTHTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPYKCNECGKVFTQNSHLASHRRTHTGEKPYQCNKCDKAFSVRSSLTTHQAIHTGEKPYTCSECGKVFSRSSNLTSHQRLHVGQKHM---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96SE7-1", "uniprot_id": "ZN347_HUMAN", "id": "Q96SE7-1", "name": "Zinc finger protein 347", "aln": "MALTQGQVTFRDVAIEFSQEEWTCLDPAQRTLYRDVMLENYRNLASLGISCFDLSIISMLEQGKEPFTLESQVQIAGNPDGWEWIKAVITALSSEFVMKDLLHKGKSNTGEVFQTVMLERQESQDIEGCSFREVQKNTHGLEYQCRDAEGNYKGVLLTQEGNLTHGRDEHDKRDARNKLIKNQLGLSLQSHLPELQLFQYEGKIYECNQVEKSFNNNSSVSPPQQMPYNVKTHISKKYLKDFISSLLLTQGQKANNWGSPYKSNGCGMVFPQNSHLASHQRSHTKEKPYKCYECGKAFRTRSNLTTHQVIHTGEKRYKCNECGKVFSRNSQLSQHQKIHTGEKPYKCNECGKVFTQNSHLVRHRGIHTGEKPYKCNECGKAFRARSSLAIHQATHSGEKPYKCNECGKVFTQNSHLTNHWRIHTGEKPYKCNECGKAFGVRSSLAIHLVIHTGEKPYKCHECGKVFRRNSHLARHQLIHTGEKPYKCNECGKAFRAHSNLTTHQVIHTGEKPYKCNECGKVFTQNSHLANHQRIHTGVKPYMCNECGKAFSVYSSLTTHQVIHTGEKPYKCNECGKVFTQNSHLARHRGIHTGEKPYKCNECGKVFRHNSYLSRHQRIHTGEKPYKYNEYGKAFSEHSNLTTHQVIHTGEKPYKCNECGKVFTQNSHLARHRRVHTGGKPYQCNECGKAFSQTSKLARHQRVHTGEKPYECNQCGKAFSVRSSLTTHQAIHTGKKPYKCNECGKVFTQNSHLARHRGIHTGEKPYKCNECGKAFSQTSKLARHQRIHTGEKPY---ECGKPFSICSSLTTHQTIHTGGKPYKCNVWKVLKSEFKPCKPSQNS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TKY4-1", "uniprot_id": "A0AB32TKY4_DANRE", "id": "A0AB32TKY4-1", "name": "", "aln": "--------------MAFIKEESE-----------DVKIE-------------------------ETFSVKNEDLQEQTDLVKEYERSKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEHHVKIEDKTHLETDDILKMRDK-------------------------------------------------------RCFTCNQCGKSLANKSKLKIHMRIHNREKLFTCTQCGKNFNQSSNLNQHMRIHTGEKPFTCTQCGKSFSQSSNLNLHMRIHTGEKPFTCSQCGKSFSQSSSLNLHMRIHTGEKPFTCTQCGKSFSQSSILNIHMRNHTGEKPFTCLQCGKSFSQSTYLNQHMRIHTGENLFTCTQCGKSFSNSANLNLHMRIHTGEKPFTCTQCGKSFSQSSNLNIHMRIHTGEKPFTCSQCGKSFSQSPYLNHHMRIHTGEKPFTCSQCGKSFSKSSNLNIHMRIHTGEKPFTCTQCGTSFSQSSNLNI----------------------------HMRNHTGEKPFTCLQCGKSFSRSTSLNRHMMIHTGEKAFMCLKCENTFITAAELKRHQRVHTGEKPYKCSQCSKRFARSGTLKTHERIHTGEKL--------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * :** ** :* .::::.: . *: :: * : : * . :: :* : :.**.***:: :*.* * *. :* :.*.:*** *.*.* *. * * ******: *.:*** *. *.* * *******:.* :*** * :.* * * *******:.*.:***:* * *. * ******:.* :*** *:*.::* .* :*:* : : * :*** ** :.* * :******:.*.:*** *: * * * *******:.*.:*** * :.. *. * ********: .: **:*.. ***. * ****:**:.* :**. *:*.*:* * * ******: * :***:** :**. * ****:*.: * :* :.* :.* *: *******:*.:*.* *: ..* *: ****** ", "identical_positions": 200, "similar_positions": 119, "identity": "23.75%" }, { "cls_id": "homologset.agr.HGNC:16448", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VI04-1", "uniprot_id": "ASGL1_RAT", "id": "Q8VI04-1", "name": "Isoaspartyl peptidase/L-asparaginase", "aln": "MATARPSSCGRDSVPATPRASIDVSLVVVVHGGGASNISPGRKELVSEGIAKAATEGYNILK-----AGGSAVDAVEGAVTMLENDPEFNAGYGSVLNADGDIEMDASIMDGKDLSAGAVSAVRCIANPVKLARLVMEKTPHCFLTGRGAEKFAADMGIPQTPAEKLITERTKKHLEKEKLEKGAQK------------ADCPK---NSGTVGAVALDCKGNLAYATSTGGIVNKMVGRVGDSPCIGAGGYADNNLGAVSTTGHGESILKVNLARLALFHVE-QGKTVDEAATLALDYMKSKLKGLGGLILINKTGDWVAKWTSASMPWAAVKNGKLQAGIDLCETKTRNLPTC-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C0M9-1", "uniprot_id": "ASGL1_MOUSE", "id": "Q8C0M9-1", "name": "Isoaspartyl peptidase/L-asparaginase", "aln": "------MACARGTVAPPVRASIDVSLVVVVHGGGASNISANRKELVREGIARAATEGYKILK-----AGGSAVDAVEGAVTVLENDPEFNAGYGSVLNVNGDIEMDASIMDGKDLSAGAVSAVRCIANPVKLARLVMEKTPHCFLTGHGAEKFAEDMGIPQVPVEKLITERTKKHLEKEKLEKGAQN------------ADCPK---NSGTVGAVALDCRGNLAYATSTGGIVNKMVGRVGDSPCIGAGGYADNNLGAVSTTGHGESILKVNLARLALFHVE-QGKTVEEAAQLALDYMKSKLKGLGGLILVNKTGDWVAKWTSASMPWAAVKNGKLQAGIDLCETRTRDLPC--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7L266-1", "uniprot_id": "ASGL1_HUMAN", "id": "Q7L266-1", "name": "Isoaspartyl peptidase/L-asparaginase", "aln": "-----------------------MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILR-----EGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQK------------TDCQK---NLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIE-QGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5BKW9-1", "uniprot_id": "ASGL1_DANRE", "id": "Q5BKW9-1", "name": "Isoaspartyl peptidase/L-asparaginase", "aln": "-----------------------MLPVVVVHGG-AGHIPKERTEESTIGVKEAARTGYAILQ-----RGGSAVDAVVEAVALMETNPRFNAGRGSVLNIKGEVEMDALVMDGRTLDSGAVSAVRRIANPVQLARLVMEKTKHLCLTAEGASKFARSMGVPEVPEESLITDYAKMRWKKN-LEPDANP------------VECQMG--KMGTVGAVAVDMDGNIACATSTGGMINKMEGRVGDTPCVGCGGYADNKIGAVSPTGHGEAIMKVTLSRLVLFHME-QGKTPEEASDLALAYMKERVDGLGGVVVVDHNGTWAARFSSLQMSWAAAQQGKLHFGLFHGDHFTEPVEEHT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VXT7-1", "uniprot_id": "ASGL1_DROME", "id": "Q9VXT7-1", "name": "Probable isoaspartyl peptidase/L-asparaginase CG7860", "aln": "----------------------MPRPVLLIHGG-AGDISDSRIAGKFAGIKQALRSAWGLLSPDNGSGGGSALDAVEAAVRSMELDENFNAGYGSCLNTSGQVELEASLMEGRDLRAGCITLLRDVMHPITVARRLMEKQRHTFLGGAAAQELALATGSERLQPGALVTEGARLTLKEFEDQVAQGKDPFFARTELTDDKPVPKTDPSGETVGAVAMDASGQIVVGTSTGGITGKWPGRIGDTPILGSGTYADNCRGGVSTTGHGETLMRYNLAQRILSAMEYQGLSAQAAADKECREMTKRLGGTGGAIVVGHSGDLGISFTSRRMAWGYVQDGTIFYGIEGQVVHQEPFTLST", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::::*** *. *. * *: .* .: :* ****:*** ** :* : .**** ** ** .*::*::* :*:*: * :*.:: :: : :*: :** :*** * * .* ::* * . *:*: : :: : . ******:* *::. .*****: .* **:**:* :*.* **** *.**.*****:::: .*:: * :* ** : : *: *..:: * ** :::.:.* ::* *.*. .::*.: *: . ", "identical_positions": 96, "similar_positions": 90, "identity": "27.04%" }, { "cls_id": "homologset.agr.HGNC:16449", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VH31-1", "uniprot_id": "RFPLA_MOUSE", "id": "Q8VH31-1", "name": "Ret finger protein-like 4A", "aln": "MAHLFKEKSNCYFCFRCLESPVYLNCGYICCLKCLDSLEKSPEGDGVLCPTCSVVSLKEDIIHAKQLGALVTKIKNLEPQLNFILTMDQGMKIFQVTMTLDVDTAQNHLIISDDLLSVYYTPQKQARKKCAERFHPSPCVLGSSRFTSGRHYWEVVVGTSKEWDIGICKESINRKKAIHLSEKNGFWTVGVRAKKVYSASTDPLTVLRVNPRLRRVGIFLDMLEKSVSFWDLSDGSHIYTFLEIPDTDPFRPFFSPASSYPDGDQEQVLSICPVTNPGIFGIPVNPQ--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ABM4-1", "uniprot_id": "RFPLA_RAT", "id": "D4ABM4-1", "name": "Ret finger protein-like 4A", "aln": "MAHFFKENSSCYFCFRYLENPVYLNCGYICCFQCLDSLEKSPEGDGVLCPNCSVVSLKEDIRHAKQLRNLVTTVKDLEPQLNFILTMDPSMKIFQVNMILDVDTAQNNLIISEDLRSVYHTSQTQDRKKCAERFDPSPCVLGSSRFTSGCHYWEVVVGTSKEWDIGICKESINRQEVVYLSEKKGFWTVGVRNEEVYAASTDPLTVLLVNPRLHRVGIFLDLLEKSVSFWDLGDGSHIYTFLEIPDTEPFRPFFSPANTYPD--EEQVISICPVMNPSIFGLPVNPV--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A6NLU0-1", "uniprot_id": "RFPLA_HUMAN", "id": "A6NLU0-1", "name": "Ret finger protein-like 4A", "aln": "MAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQD--DQSILSICSVINPSAASAPVSSEGK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. **: * .*:: **..* *:*** **::**:**:*.*:*:*:** ***** *:** :* **: :*:***:*: :***: *: *** * :*****:* ****:** *. .* **: ****..: ****:.***** ***** ****: **:*:****:**: : **.::** *** * :*::*** *:* * *.*:*:*******: :*::*:::.**.*****:*** :*:****: * ::.::***.* **. . **.. ", "identical_positions": 147, "similar_positions": 76, "identity": "50.87%" }, { "cls_id": "homologset.agr.HGNC:1645", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P24807-1", "uniprot_id": "CD24_MOUSE", "id": "P24807-1", "name": "Signal transducer CD24", "aln": "MGRAMVARLGLGLLLLALLLPTQIYCNQTSVAPFP-GNQNISAS---PNPSNATTRGGGSSLQSTAGLLALSLSLLHLYC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q07490-1", "uniprot_id": "CD24_RAT", "id": "Q07490-1", "name": "Signal transducer CD24", "aln": "MGRAMVVRLGLGLLLLALLLPTQIYCNQTSVAPFS-GNQSISAA---PNPTNATTRSGCSSLQSTAGLLALSLSLLHLYC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P25063-1", "uniprot_id": "CD24_HUMAN", "id": "P25063-1", "name": "Signal transducer CD24", "aln": "MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******.******************..:*:... . ..*. * : ***:****:.. .:*****.*:.:********.", "identical_positions": 48, "similar_positions": 24, "identity": "60.0%" }, { "cls_id": "homologset.agr.HGNC:16451", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "id": "O09108-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACD----------------LP---HLPG-----LLLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01230-1", "uniprot_id": "LSHB_RAT", "id": "P01230-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMTCD----------------LP---HLPG-----LLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P0DN87-1", "uniprot_id": "CGB7_HUMAN", "id": "P0DN87-1", "name": "Choriogonadotropin subunit beta 7", "aln": "MEMFQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :***** **** . .**** *** ***:*****.*:* ******..*:*******:*.*** ..**.:** **.**:: * *:****** **:*:**:.*****:*. ** *::*****: :*::** ** :*** :* ", "identical_positions": 90, "similar_positions": 33, "identity": "54.55%" }, { "cls_id": "homologset.agr.HGNC:16452", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "id": "O09108-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACD----------------LP---HLPG-----LLLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01230-1", "uniprot_id": "LSHB_RAT", "id": "P01230-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMTCD----------------LP---HLPG-----LLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P0DN86-1", "uniprot_id": "CGB3_HUMAN", "id": "P0DN86-1", "name": "Choriogonadotropin subunit beta 3", "aln": "MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :***** **** . .***: **** ***:*****.*:* ******..*:*******:*.*** ..**.:** **.**:: * *:****** **:*:**:.*****:*. ** *::*****: :*::** ** :*** :* ", "identical_positions": 90, "similar_positions": 34, "identity": "54.55%" }, { "cls_id": "homologset.agr.HGNC:16453", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "id": "O09108-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACD----------------LP---HLPG-----LLLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01230-1", "uniprot_id": "LSHB_RAT", "id": "P01230-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMTCD----------------LP---HLPG-----LLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P0DN86-1", "uniprot_id": "CGB3_HUMAN", "id": "P0DN86-1", "name": "Choriogonadotropin subunit beta 3", "aln": "MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :***** **** . .***: **** ***:*****.*:* ******..*:*******:*.*** ..**.:** **.**:: * *:****** **:*:**:.*****:*. ** *::*****: :*::** ** :*** :* ", "identical_positions": 90, "similar_positions": 34, "identity": "54.55%" }, { "cls_id": "homologset.agr.HGNC:16454", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESQ4-1", "uniprot_id": "NMUR2_RAT", "id": "Q9ESQ4-1", "name": "Neuromedin-U receptor 2", "aln": "-------------------------------------------------MGKLENASWIH-----DPLMKYLNSTEEYLAHLCG----------------PKRSDLSLPVSVAYALIFLVGVMGNLLVCMVIVRHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQHFPNGSS-VPGSATCTVTKPMWVYNLIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEAN--------------------------KVAVNIHRPSRK-------------------------SVTKMLFVLVLVFAICWTPFHVDRLFFSFVE------EWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPTCKWCHP-------------------------------------------------------RHRPQGPPAQKIIFLTECHLVELTEDAG--------------------------------------------------------------------------------PQFPGQSSIHNTN--------------------LTTAPCAGEVP--------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BZ39-1", "uniprot_id": "NMUR2_MOUSE", "id": "Q8BZ39-1", "name": "Neuromedin-U receptor 2", "aln": "-------------------------------------------------MGKLENASWIH-----DSLMKYLNSTEEYLAYLCG----------------PKRSDLSLPVSVVYALIFVVGVIGNLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSS-VPGSATCTVTKPIWVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEAD--------------------------KVTVNIHRPSRK-------------------------SVTKMLFVLVLVFAICWTPFHVDRLFFSFVD------EWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHP-------------------------------------------------------QHRPQGPPAQKVIFLTECHLVELTEDAG--------------------------------------------------------------------------------PQFPCQSSIHNTQ--------------------LTTVPCVEEVP--------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9GZQ4-1", "uniprot_id": "NMUR2_HUMAN", "id": "Q9GZQ4-1", "name": "Neuromedin-U receptor 2", "aln": "----------------------------------------------MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCG----------------PRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSL-VPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEAD--------------------------EGNANIQRPCRK-------------------------SVNKMLFVLVLVFAICWAPFHIDRLFFSFVE------EWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHS-------------------------------------------------------QHDPQLPPAQRNIFLTECHFVELTEDIG--------------------------------------------------------------------------------PQFPCQSSMHNSH--------------------LPAALSSEQMSRTNYQSFHFNKT--------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VFW6-1", "uniprot_id": "Q9VFW6_DROME", "id": "Q9VFW6-1", "name": "", "aln": "----------------------MAVKMLPTN-----------SSGVLAT-----DLQLFHNEKFLLNLTQVLNISADNLTSLL---QGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVVMQGM---------GTSCTMKN--DFFAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQ---ALPRR--------------------CYDVNRGISAQT-------------------------RVIRMLVAVAVAFFICWAPFHAQRLMAVYGS---TSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKVTLARHFGLGG---KNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTT----------MTSMATTTTGLNGSANGSGNGTTTGQSVRLNRVSLDSVQMQ-------GQNRSRQDLFDN------PRRMLQTQISQLSSVGDAHSLLEEDLQFPGEPLQRQPTMCSIDELTDDLAISRSRLKLTRITRPPGGVTGGVAGGSTTGAAGSGGVSGDESSGKVRKAKVKVLKSSSPFKGLRTKFNWRARRKGSHKPHEKGATVNGGDTEERAAF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VFW5-1", "uniprot_id": "Q9VFW5_DROME", "id": "Q9VFW5-1", "name": "", "aln": "MLQGVAITIANDSNDDGINQSFMAHVSPSPNQSPSIGVGIGIASSTMANPSESPEMLLLKNDKFLTHVAHLLNITTENLSNLLGSTNGTNASTMAADSPVDESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNE---------GYSCTMEN--DFYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQ---SLPRR--------------------TFDANRGLNAQG-------------------------RVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLR-QNGSMRLQPASCSVNNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTTTTTTTINSNSMAAGNGVGGGAGGGGGGRRLRKQELYGPGPGTAVPHRMLQAQVSQLSSLGDANSLLEAEVVDRHYASGRAKRALLATKSGALLVTPPQSGDPSEVSQPATRLKLTRVISRRDEVAN---TSTPPFCGSHSLPDPETCQSASVAGRSSRKFPWRKRRQKTEDPSSEGLTYGSPKSQ-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8ITC9-1", "uniprot_id": "PK1R_DROME", "id": "Q8ITC9-1", "name": "Pyrokinin-1 receptor", "aln": "-------------------------------------------------------------------------MSAGNMSHDLG--------------PPRDPLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYSG---------VEQCGIVR--VIVKHSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIYAP--ARGAKLRDQHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFG---------------------------------------------------------------KKVSKGSLNSRNNIESRRLRRALTNS-----------------------------------SQTQRFS------------------------------------IESAEQPKPSIMQNP---------------------TNKPPVAAQYAMIGVQVN-------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8ITC7-1", "uniprot_id": "CAPAR_DROME", "id": "Q8ITC7-1", "name": "Neuropeptides capa receptor", "aln": "-------------------------MNSSTDPTFSELNASFTNTPDTLFATSVSSDPSHGFGEEDYACGTFNCSPKEFVAFVLG--------------PQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMSPKIVNEIPVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLG-------------------------VQQGTNNRETRNS--------------------QMRKKTVIRMLAAVVITFFVCWFPFHLQRLIFLYAKN-------MDNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGKAVGAYYN--------------------------------------------SGFARDHSSFRESSAYDRVHSVHVRASQHPNKFETDSS-------------------------------------------------------------------------------SANRVLIKKTYSLP--------------------LPKNADSTVLSTTDIVIVLENSHTVCEEPKVENDIWIENEETCI-----------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: ::: : **:.**:**: .*:** :: ::*.**:***.**:**:: * *:* :: * * * : * .:::::.:.::**::** **: **:::: :* :.: ::* .: * : : : :*: ** * :** :. :: : * * :** .:.: * :** *** :**: : : : :*. :::* :**::*.::*:::: **: : . . . . . . ", "identical_positions": 63, "similar_positions": 98, "identity": "8.65%" }, { "cls_id": "homologset.agr.HGNC:16457", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P58500-1", "uniprot_id": "M3KCL_MOUSE", "id": "P58500-1", "name": "MAP3K7 C-terminal-like protein", "aln": "--MISTAR-----------VPADKPVRIAFS-------------------------LNDAPDDTPSEDAIPLVFPELEQQLQPLPPCHDSVESMQVFKQHCQIAEEYHEVKKEIALLEERKKELIAKLDQAEKEKLDAAQLVQEFEALTEENRTLKMAQSQCVEQLENLRIQYQKRQGSS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P57077-4", "uniprot_id": "M3KCL_HUMAN", "id": "P57077-4", "name": "MAP3K7 C-terminal-like protein", "aln": "--MISTAR-----------VPADKPVRIAFS-------------------------LNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0LTI0-1", "uniprot_id": "A0ABK0LTI0_RAT", "id": "A0ABK0LTI0-1", "name": "", "aln": "MELRSNPRSLEVQISSLCLVTSLKSTRKPLPGFTTLHSSRLPRKGLYATGRPQDMQVHDPRNDTPSEEATPLVFPELEQQLQPLPPCHDSAESMQVFKQHCQIAEEYHEVKKEIALLEERKKELIAKLDQAEKEKLDAAQLVREFEALTEENRTLKMAQSQCVEQLEKLRIQYQKRQGSS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E7F0K5-1", "uniprot_id": "E7F0K5_DANRE", "id": "E7F0K5-1", "name": "", "aln": "MDVDVSAE-----------TLELRYQILSFSYQACYS------------------ACVFLSELKDAEDPLP-SFPDLEQRLQPVLPCRSLKESIEVYKDHCKMANEFNQVKHEIARLEDRKKELMAELLEDEKASMEFARYEEEYRILTEENQNLITVHSERAQQLETLRVISQKRQGSS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ... . : .:. : . .*:. * **:*:*:***: **:. **::*:*:**::*:*:::**:**: **:*****:*:* : ** .:: *. .*:. *****:.* .:*: .:***.**: *******", "identical_positions": 55, "similar_positions": 52, "identity": "30.56%" }, { "cls_id": "homologset.agr.HGNC:16459", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ARB3-1", "uniprot_id": "A0A8I6ARB3_RAT", "id": "A0A8I6ARB3-1", "name": "", "aln": "MCATRRGARCSPRRRRGGEFAQGRGSQSERRRAEGGRTPRGGVGTWGPGWAGPAALPVGGSGWRRRPGRGGARCRLRCGGGGNNSADRGARTASRGAGRGTMNEEEQFVNIDLNDDNICSVCKLGTDKDTLSFCHICFELNLEGVPKSNLLHTKSLRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTILSKKINWIVQYAQNKNLDLDSECSKTSQHHLFNFRHKPEKKLLPQFDSQVPKYSAKG-LAGSAVGISSYTQRILDHREDTDFGLGILEDADA-------LWTHSHNQAQKTEETSSVPERSVQTQSPRYSREELNSMTLAEVVQLSTKLRQQIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNCSKLPCLQVGRTGTRPHLSTNN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D7G4-1", "uniprot_id": "EURL_MOUSE", "id": "Q9D7G4-1", "name": "Protein EURL homolog", "aln": "-----------------------------------------------------------------------------------------------------MNEEEQFVSIDLNDDNICSVCKLGTDKDTLSFCHICFELNLEGVPKSNLLHTKSVRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTIVSKKINWIVQYAQNKNLDLESECSKTSQHPLLNFRHKPEKKLLPQFDSQVPKYSAKG-SAGNAGSISSYAQRILEHRENTDFRLGLLEDADA-------LWTHSHSQAQKTEETSSGPEGTIQTQNPHYSREELNSMTLAEVVQLSAKLQQRIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNCSKLPCLQVGRTGTRSHLPMNH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NYK6-1", "uniprot_id": "EURL_HUMAN", "id": "Q9NYK6-1", "name": "Protein EURL homolog", "aln": "-----------------------------------------------------------------------------------------------------MNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNIEGVPKSDLLHTKSLRGHKDCFEKYHLIANQGCPRSKLSKSTYEEVKTILSKKINWIVQYAQNKDLDSDSECSKNPQHHLFNFRHKPEEKLLPQFDSQVPKYSAKW-IDGSAGGISNCTQRILEQRENTDFGLSMLQDSGATLCRNSVLWPHSHNQAQKKEETISSPEANVQTQHPHYSREELNSMTLGEVEQLNAKLLQQIQEVFEELTHQVQEKDSLASQLHVRHVAIEQLLKNCSKLPCLQVGRTGMKSHLPINN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q503Y8-1", "uniprot_id": "EURL_DANRE", "id": "Q503Y8-1", "name": "Protein EURL homolog", "aln": "-----------------------------------------------------------------------------------------------------MEEEEHFVNIDLNDDNICSICKLETDTGTLSFCHVCFELSIEGISSATLLHSKSLRGHRDCFEKYHLIANQKLSRAKASHSTYEGVKRALSQRINRIIQYAQNRDSVTPENPGRWGAKQILCHTQQAGRKLVPQSDAQVPRYAPRWTEEASMVSESDYGKSMLDCHSAEELGLG--------------LWPGERPQNREQRDSR-------QRRHSGHSREELMRKNVEELRQLNEQLLLQIQNVFEELSVVVQEKDSLSSELHVRHIAIEQLFKNCAKLPWLQIGRAGVKAANNPVE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:***:**.**********:*** **. ******:****.:**:..: ***:**:***:************ .*:* *:**** ** :*::** *:*****:: .: .: : :: . ::. .**:** *:***:*:.: .. . *. : :*: :. :: *. **. .: * :: .:: * : . :***** .: *: **. :* :**:*****: *******:*:*****:*****:***:*** **:**:* :. .", "identical_positions": 132, "similar_positions": 83, "identity": "33.08%" }, { "cls_id": "homologset.agr.HGNC:16460", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZFK8-1", "uniprot_id": "D3ZFK8_RAT", "id": "D3ZFK8-1", "name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "aln": "------------MGEIEGTYRTLPT-----SGTRLGGQTAIG--VSTLEPEQALSPKM------QEKHMHIRVKLLDSTVEIFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSY-WIWLEPMKPIIRQVRK-PKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLRRDLLEERLTCTATTSALLISHLLQSEIGDYD--ETLDREHLKANDYLPNQ-EQSLDKILDFHQRHTGQTPADSDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEHHTFFRLSDQP-KPKAKAVFFSRGSSFRYSGRTQKQLVDYIRDGGTKRIPYERRHSKTRTSLHTLTGDLPKQSISFTDGLRTSASLSSANASFYPPP-TSLSSPGLPSVKDSSSSPVDPQAPHIKSTAAERSSRPSSSEGPSTQSAHLPGPPVLQPGPGFSVDSPQPSPSSLKSRLSLSPERQAS-LSTAEQGSSPVLSP---------------------------------------------------------------VLSGTGTARMDNQEEQKHKHTSEDEAYFIAKEIVATERTYLKDLEVITVWFRSVVIKEEAMPAALMTLLFSNIDP-IYEFHRGFLHEVEQR---------------LALWEGPSS----GDHQRIGDILLRNMRQLKEFTS-------------------YFQRHDEVLTELEKATKHCKRLEAVYKEFELQKVCYLP---------LNTFLLKP--------------------------------------------------VQRLVHYRLLLNRLCTHYSPEHEDYTDCHEALKAITEVTTELQQSLTRLEN-------------------------------------------------------------------------LQKLTELQRDLVGVENLIAPGREFIR---------------------------------------------EGCLHKLTKKGLQQRMFFLFS-----------------DMLLYTSKS------------------------VTGASQFRIRGFLPLRGML-------VEDSENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKSAGDTPAVLLGGPVYTRSPRSSDEVSLE-DSED-GRGTRGSLEGNSQHR---------------ANTTMHVCWYRNTSVSRADHSAAVEN------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVS-----------------------------------LPREADSIHKDYVFKLQFKS------------------------------------HVYFFRAESKYT---------FERWMEVIKRASSSPGRPPSFTQDCSHLSPGLEAEVREKEACPSLCLDKNL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91VS8-1", "uniprot_id": "FARP2_MOUSE", "id": "Q91VS8-1", "name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "aln": "------------MGEIEGTYRALPT-----SGTRLGGQTAIG--VSTLEPEQSLSPRM------QEKHMRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSY-WIWLEPMKPIIRQVRK-PKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYD--ETLDREHLKANEYLPNQ-EKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLSDQP-KPKAKAVFFSRGSSFRYSGRTQKQLVDYVKDGGMKRIPYERRHSKTRTSLHALTVDLPKQSVSFTDGLRTSASLSSANVSFYPPPSSSLSPPGLPNLKDSSSSLVDPQAPVIKSTAAERSSGPSSSDGPSTQSAHLPGPPVLRPGPGFSMDSPQPSPSSLKSHLSLCPELQAA-LSTAEQGASPVLSP---------------------------------------------------------------VLSGAGTARMDNQEEQKHKHMPEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDP-VYEFHRGFLHEVEQR---------------LALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTS-------------------YFQRHDEVLTELEKATKHCKKLEAVYKEFELQKVCYLP---------LNTFLLKP--------------------------------------------------VQRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLEN-------------------------------------------------------------------------LQKLTELQRDLVGVENLIAPGREFIR---------------------------------------------EGCLHKLTKKGLQQRMFFLFS-----------------DMLLYTSKS------------------------VTGASHFRIRGFLPLRGML-------VEESENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKTIGDSPPVLLGGPVYTRTPRSSDEVSLE-ESED-GRGNRGSLEGNSQHR---------------ANTTMHVCWYRNTSVSRADHSAAVEN------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVS-----------------------------------LPREADSIHKDYVFKLQFKS------------------------------------HVYFFRAESKYT---------FERWMDVIKRASSSPGRPPSFTQDCSHHSPGLEAEIREKEACPSPCLDKNL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O94887-1", "uniprot_id": "FARP2_HUMAN", "id": "O94887-1", "name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "aln": "------------MGEIEGTYRVLQT-----AGMRLGAQTPVG--VSTLEPGQTLLPRM------QEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSY-WIWLEPMKPIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYD--ETLDREHLKVNEYLPGQ-QHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQP-KPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSP-STLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSG-AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVP-LGPAEQGSSPLLSP---------------------------------------------------------------VLSDAGGAGMDCEE-PRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDP-IYEFHRGFLREVEQR---------------LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTS-------------------YFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLP---------LNTFLLKP--------------------------------------------------IQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLEN-------------------------------------------------------------------------LQKLTELQRDLVGIENLIAPGREFIR---------------------------------------------EGCLHKLTKKGLQQRMFFLFS-----------------DMLLYTSKG------------------------VAGTSHFRIRGLLPLQGML-------VEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHR---------------ANTTMHVCWYRNTSVSRADHSAAVEN------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVS-----------------------------------IPREADGIHKDYVFKLQFKS------------------------------------HVYFFRAESKYT---------FERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3ATD1-1", "uniprot_id": "A0A8M3ATD1_DANRE", "id": "A0A8M3ATD1-1", "name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "aln": "------------MGEIEGSYRSLQTP----AGSRLGGQHNTG--ISTLEPGQSLSSAMGAGGKGHNKGLQIRVQGLDEAQEFYELESKADGQLLLSDVFRRINLIESDYFGLEFQNLQMN-WVWLDPSKLIVKQVRR-PMNTLFRLSVKFFPPDPGQLQEEFTRYLFSLQIKRDLLDGRLSCTENTAALLASHLVQSEIGDYD--DLADREFLKMNKLLPCQ-EHVQEKIMELHRRHTGQTPAESDFQVLEIARKLEMFGVRFHPAADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPEVHGPHQDTLEFLMGSRDQCKIFWKNCVEHHSFFRLLDQP-QPKSKAIFFSRGSSFRYSGRTQKQLVEYVRDSGLRRTPYQRRNSKIRMSTRSLASDVPKQNLSFNDSLRTHIPPSSITASF-----QSLHAPSVSMRAETPNQLLHLHQTQHQPLRAPSPMKQDPIKTNSQSTYAFPDS--------IAIDSPQLSPFNDKGPLCLSPSFQMSTLSLPGQAPSPLQSP---------------------------------------------------------------ILNEVGTARLDEDEEGRRKRYPTDKAYFIAKEILTTERTYLKDLEVITVWFRSAVIKENAMPEGLMTLLFSNIDP-IYEFHRGFLKEIDQR---------------LALWEGRSNAHVKGDYQRIGDVMLRNMCSLKEFTG-------------------YLQKHDEVLTELEKATKRVKKLETVYKEFELQKVCYLP---------LNTFLLKP--------------------------------------------------IQRLMHYKLILERLCKHYSPQHRDYDDCKEALKEVAEIATQLQSSLIRLEN-------------------------------------------------------------------------FQKLTELQRDLIGIENLTAPGREFIR---------------------------------------------EGCLYKLTKKGLQQRMFFLFS-----------------DMLLYTSKG------------------------VTATNQFKVHGQLPLHGMILIVLDAPVEESENEWSVPHCFTIYSAQRTIVVAASSKVEMNKWIEDLNMAIEMSKKCQEKSDVLLDPSLCDRSNRSSDEVSLEQESEDDMNSSRCSLDKQSHHR---------------ANTTMHVCWHRNTSVSMSDHSLAVEN------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDFPLASLPLLGYTVS-----------------------------------TPGESDSIHKEYVFKLQFKS------------------------------------HVYFFRAESEYT---------FERWMEVIKSAASATGRMSLLVPKGP-------AEVNVGN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A8JQT5-1", "uniprot_id": "A8JQT5_DROME", "id": "A8JQT5-1", "name": "Moesin/ezrin/radixin homolog 1", "aln": "MSLADMGTASRSAGGEGGRHYDLATGGAGSGGHPVGGGLPGGRMTHSLSTPSGVDGTPSTPRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTHTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAAWDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPGDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTVVRSVDLNSSMELEEEAEDPGTADTEEEEGEPVGEEEEEELVEEEVDSDLTASTINRETMGAASAAAASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANSTETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHFSDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGSYQYHNDLNHPSESSSSSYFGTGFGTKRYGQSERTKLAQSENYLTPSLDSQSSRHTHSLPRNSELSGVDSVDSYDSHYITHHSVGILPPGHLSSSSEKLDFQLPSGNLYSTTQFVKPEDASAHYMEDEEEEEEDEGENIYDQVERDSWLKSSSCKDLFERYSSTYYDREHSKPMTAFDKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYPGSTYNTQEHKRQHGHHMDYSGSQDDISQDSYELLEKYDIDFFGGRGRSEDHMRSCSLDSGNYIPSDDESVSEGHQQHKYRSEMDVKSKSAADIMNEIWDAEDPRYLPREKLSVKSDGNFYKKIQEALVRTSSLESQSEMFETKISRSSDSSKKSRDSLYHTDSKKSRETTKSKTSVASSQDSKESLVGDCFGRNYEMPTTTGKKVKQFTKKELYEKFAQSSQESKSDYYDAVETGLEHTPEGLYSRPKVKSHDCLLSDTHSSTANSSFYDSRDTYSTFPSNKTHKTSKVHSISLQNVEIERNAKSFGSKSPESVSTPASGKRCREKDIQTGDSLDQMAPIKRGNSQSCKISAFRRRSDSENIFSFDQDRIECIQKYTKQWEGQQPKDEKSKQSPEYPLTPELVSEFEKQQARLMAHQKITRKEELIAKTHFEEYNPIMVPLNYSSHATVERTKSDPNSLANRARLGSNSRRHVLMHQKSIDLTPADSNSSDEDYIYKQIPSAPPLCKAHGNFEIPKCYDGSAASQIAQELPKTGFELPKSFFRDYERRFTKVLKEDIPYVLHKRHIMNGTAPSPSEKKHTKPKSPKSPKSPKSPKSPKSPKSPKASSGGLGPGSTDFLPDILDSLLPSDTKEFLFTQNIDLSKVDPITLEIDKTIPTIHLSSPKRDITKQMDASTLEKLNKKLSQIESDSATSSRTESMQQQKLEQKQMELIQSLRKELQANARKANKPRVIPKTKSAGKSKKGKTRITSFSSDDESLDSDDVFGSAEAIPDRLEFSPPQSRKEIESILRIEQSRLISAAWGRGQTMSSTEIEGSPPQCRRLADLESRYHTQKLDPQYANATELRRISERSISIPSSEDEPHMPMRGRIDECTNDYQRNENIPSPILEHAEFFRSNDDIYETCHEERITGSDIDYTLKKQTSSGSKSKVKLIEEIIDSSIVMRSKGHAPILFAHARLNLSEGSVSLQRQKATQQQSPTTERRTKSLDTPVISLHRLPPMNAFSSKDDTVGFEEEAEILEEKSLERENQATAQDEDTADSIHSCAGSIPTQSSYQTNGRDSLLSAVSIDTEEAELLNQLRYIEKIALQGVKIKDKKKSKMKLRSGDHLILNIPKYRFTDWSPYSSANSSRKTSPGVSRASSIESTGKGKLKTSEPYKGKPVSRSRPESRRTSADDIKARDGRGSKKSSPKERPRSIEMRRLSKDKSKSQEETEADIAKRKERQQKLYESAMKQTITMLSPVKDTLPAFPAPGDKILVKTDGDKIIIETEFKSKAEDHVLIAKSPRKLDNSLVKFSRSFDEGRSPDKLDKANRSFEDRNKSFEDSEKSDAPEDMLIKSPKKIAKAQELKQKIEGSVVHKKIDGKSSSLERPAEHHYLGPDVKARSLDDKRQATEAAKKNEEKPAPVVRSAIGDRRMFAHQYQVQEPHQEDIDMQAVISERRSLEILKRSLPSEDARDSEGAFSRKPSTAESLDSYVSVDESHSAASKSPVPGTGGGTEGYPHRVPTIECEEPSIEEDENSSERRHLKVGGQDTNRLSLDRSRSDETGSWMTVECDEFIGSDTSDNEPRTLEPDRNVLETQATLEDANPLEYSNCATPTSDLNILLTPPNASPQIEKSVLETFEKYTGSSDTGKKKNTLDKQSDRSKSSDSWTSGEKDTSPQRQQDWSLSVGKEKSSVEEESSVSCSIARPLGISQDFGKEEARKCQELKQRMLQLEVGKEEITPTPSNEQTPTNEPKILVSKKPSTPTLEKQSPIDLGTSTESYLEPIEERIAKILDRGGARTEDSESSSGGSRKPPRIEKPARANAGKKLSVTRADAGKSGSDRSSQESKSSFDSKGSLSVESRGSFETESSSGSLGAAQRRGELAQKEQQSTWRPFPIESSNSSSTDDPWHHVETDGGYERYDAQNPLRDSSDSDVKEASPDDQKDASDASYQDELNDFPATFGYPAMTSSLGGIGVNPTDIIGYSTGFTLGRTLSRISERSTASEKSSMEDDVSKASTHSVSMRDESVGSTDHQPSLSSDSRSNTNLAYISDADRRTSAEMPEIPCDSATGDRLSSFGSLNEPKSPTLVTGRFSVTHVDEQQGDDVERHTLMCLSNAGSQDSEDWPLPEIPFDHVPVKPADSLYAMPDLDKPVPKSFCWKASLSFQQSQDSLDWPSPPSSAIGAPIIVENIETYYASEVQSADKVILDEEMAVGPPDVAKVLPYEDTAYLMSAAFDDNDFGNEQLQPDTVSCLSSTLSAASCLSSSLNVSCTTSSTQATARALRKNSSPEVIVAQPTRSPAPRSPLSEDELFSSDDVFMPGTIKVQLSPDAQLRKLSKGSNNSDTSIDDILSGSTTYLEDQTTVRKNYEARLSSGGGGASCKKCSHSSHSEEETSSLGTDLDGTVRMGGLQQKKCTHSSHSEDTSIGLSISEWSTGTNTVRQYANLSGSDSLSAVSTHSCAKSEKSNQTKSSISSINKSAESLNEQSGGSSFSHKFSGDNGSSDGLRYDMLSNSETDKLSEATSATRSDDTTLTLTEMAHTISEWSTSSSRTLVGVAPGEYLPLKQALSGNKTSLSSPSEEKRCALPQVHRRSGSNGNQARAAQEHADSQTGPETSAAARKRRSLEMMSKLYQSQEICSESESPFVERLYAHSEKLTERYQSQEFVPLHGGPPASHLASSTTSQIQTQQPQQVRQKPRAPQPPTKPKPAVTRPIMQALLNKMKQPGLAEQAAEAAEAEEKKAMIAASAVAAKPPPPPVPTVPPIVTPSDLPGDAVAPPPKPLAKHHSYDDRTLSKTQIREFKTTSKQLRQSSSFHEHMLSKSQQSSQELPMRIDEERDPHSTSSATNTTTTTNTLNSESTEPNSPQMPQRADKLVRCSPYYSSSLSSESPPNQLLQKPPRKTATQLSAGAVAASLKSPPSGNDTDSSLDVRGQEAKMRSRGYRKKRQLPVKRMRANLTAAALLEQAESSECSEGYVPEVDSGSSEYSSCQRDDQYLEFDEELERDQTDDYEDYPQYSGKFESLDMSDNVDEMGFPRYDRLSHITKPMYHQALVMERPNPVQLPAPANHPMPPATGQPVKPARTKKRQFKREDSTAAGTSGHSTAAPQVRPYHGRSYCNPEESEYETRGGGLSDELANSSEDSCSGFGGDAGASGSGTIRRGTTKGAGQDQEQGTGGQARHVPYPDFLSDYESEPIEYERYACGLDIRVDPPPKFHDSDELSDQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * : * * .* :*. * :*.. . : * : :*:: **.: :::::.*. *::*: :* :::**:*.****:*::: . **: * : :*: : ::*:.:**:.***.**:**:*****.**::*** * * .*:**: *:::*:. **: : *: .*. :* * **:: *::*.**:**::*:::** **: *::*:::* * * **. ::***:***: ***. *:****.*:*:**:********:***** :* ::**:**:: .*::** *** *** * *** *: *: .:**********:****::::.::. :* ::* :* : . .: : . .: :. . .. . .: : :: .. :: . . :. : : . . : . :. .*.* . . . .. .* :: .. * .. . * : : *. * : ** : *.: :* . : * :.. : . ** *:. :.: :: .. . . .::: :: .: .:. ::.:::: : ::: :* : : . .** *.: . : .:* :* :* : . * *. * . :. *. : .: : . : : . ::: :. * : : * .:**: *. :: :: *: .: :* *: :: .:. . .:.: :. : ::. : :::: :*: :: .: . : . : . . :: . . . .: :.. *.: . * .. : ** . * ::. :: : :.:. * :*: ***. *: *: :*::.:. :*. :: *** ::: :** : : * :::. .::*::* .: : :* * .:* . : .::: ::.:... . . . . ", "identical_positions": 209, "similar_positions": 382, "identity": "4.89%" }, { "cls_id": "homologset.agr.HGNC:16461", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5PQQ2-1", "uniprot_id": "WBP11_RAT", "id": "Q5PQQ2-1", "name": "WW domain-binding protein 11", "aln": "MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVLQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDMSSTSEDDGYPEDMDQDKHDDSTEDSDTDRSDAESDGDEFGHRDDSERDNTEEKKSGLSVRFADMPGKSRKKK--KNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEEEDDDDSEDSEAEKPSQKQHKEDSHADGSSAASSQQQAPPQAVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMP-GIRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQRPKADDAS------------------------AATIEKKAT-------------ATISAKPQITNPKAEVTRFVPTALRVRRENKGATAVPQR-RSEEDSAVPVAKAAPRSGPSVPVSVQTKDDVYEAFMKEMEGLL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q923D5-1", "uniprot_id": "WBP11_MOUSE", "id": "Q923D5-1", "name": "WW domain-binding protein 11", "aln": "MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPARAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVLQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDMSSTSEDDGYPEDMDQDKHDDSTEDSDTDRSDAESDGDEFGHREDSERDNTEEKKSGLSVRFADMPGKSRKKK--KNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEEEDADDSDDSEAEKQSQKQHKDDGHSDSTAAASSQQQAPPQSAPASQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMP-GIRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQRPKADDAS------------------------AATIEKKAT-------------ATISAKPQITNPKAEVTRFVPTALRVRRENKGATAVPQR-RSEDDSAVPVAKAAPRSGPSVAVSVQTKDDVYEAFMKEMEGLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2W2-1", "uniprot_id": "WBP11_HUMAN", "id": "Q9Y2W2-1", "name": "WW domain-binding protein 11", "aln": "MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNEEKKSGLSVRFADMPGKSRKKK--KNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMP-GLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTS------------------------AATIEKKAT-------------ATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQR-KSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P0D5-1", "uniprot_id": "WBP11_DANRE", "id": "Q6P0D5-1", "name": "WW domain-binding protein 11", "aln": "MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPRQIIRDMEKLDEMEFNPVQQPLLNEKVLRDKRKKLRETFERIVRLYERENPETYKELRKLELEYETKRGQLSLYFDSVKNAESVEVDSIPLPEMPHAPSSILIQDIPLPGAQPPSILKKSSALG---KASSLSAAALAGVPRLPAGRKPPGPPPGPPPPQILQLYG---------NTRRTEASAGSDTEMMDGGRDSDSKSEADEE-----------SDSQEDSSAEREDSDR-----GERDE-ERER-ADKHTGRSVRFADMPSPNKKKRRVVKTKSITPLQAMMLRMAGQSVPEE----EEEDEEEEYSESEDSEAEDQASTDAPQPLVNPRLPVPSAPMAAQQ---PPSLMQAPPITGPPPLGPPPAPPMRPPGPPSGPPPGPPPGAPPFLRPPGLPSALRGPMPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGMPPPPP---PPRAGPPRMAPPLSLFPPP--LNPNVLSAPPSIVPRQKSPAASSNEGAPSGSALQMPPPPGTTANPLAPTIEKRATVAGSGGASAQGGGATISAKPQIINPKAEVTRFVPTALRVRRDRAGGTGRREEERPPANQQTPAHQAPPIAHAPTPPNLKTKDQVYEAFMREMEGLL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O76861-1", "uniprot_id": "O76861_DROME", "id": "O76861-1", "name": "Wbp11/ELF5/Saf1 N-terminal domain-containing protein", "aln": "MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKKQRQMVRAAVLKNKDPSQILEEMEKIDEMEYNVLQPSPLNEKVLRDKRKKLKETFDRVMRLYHNDEPEHWADLKRKEVEYEKKRLKKQQYYESVKHAQSVQIDEIPLPAPVSAVS---------GGSTETTGGSVVAGFG---ASVVIRLPPPPMTMALPP--YAPGAPPGVSRNSDLASEA---------QVEKSKENEQKDWLGVPPGPPPDLFAFSELN-----------SDAEGNTDYDGEGEEEEPEPLKKGKDKEKDKNSEATEPNNQNIDDF---------------MKEMEHVHKRKHRKLAAKE----DEADKKREEDDGKDIDKIEERTSDSDKRTASSTDDEDDDDQDEDEN--MPEVPTKPASVKSSTATPAPAPPTAPTLPTIPLPPASSVPAPPQL--PHLP-----PIPNLGPPGIMYRPPPMRPPHPGSGFGIRMPP-GPPP--GPRAPHGLGPIPRMGIRMPPGPPPG-------------------LPPRLAHHNKQGGGAG-----------------------APKESAKGV-------------ATITAKPQIRNLSADVTRFVPSTLRVKREDQRRTARPRHAANDGHHAHSEAHSKP----------PTKDDAYLQFMNEMQGLL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***** .:*****:*************:********* ******** *** **:.:***:****:* :* . ******:******:***:*::***..::*: : :*:: *:*** ** : . *:::**:*: *:::.**** * * *: .: . :. * : : . **. .**.*** . . : . .: . . . * * : :: : .*: ::. : .. : . .: *::. : . .: *: :. :: : * : .:* :* .:. : .:..* : . .: . . .. *. ... *.**** *. *. **... *** * * :* *:*.* *** ** ** * .*: ** **** * ** *: * ** ** : : * : *.. . :.. ***:***** * .*::*****::***:*: *. .. . . :: * ***:.* **.**:***", "identical_positions": 187, "similar_positions": 151, "identity": "27.42%" }, { "cls_id": "homologset.agr.HGNC:16462", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96SI9-1", "uniprot_id": "STRBP_HUMAN", "id": "Q96SI9-1", "name": "Spermatid perinuclear RNA-binding protein", "aln": "----------------------------MRSIRSFANDDRHVMVKHS------------TIYPSPEELEAVQNMVSTVECALKHVSDWLDET--------NKGTKTEGETEVKKDEAGENYSKDQG--------GRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCVNEASIIIRNTKEPTLTLKVILTSPLIRDELE----KKDGENVSMKDPPDLLDRQK-----CLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKS--------IGTCNRPLGAGEALRRVMECLAS--GILLPGGPGLHDPCERDPTDALSY---------MTIQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSK--PFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRK-ILDSKAID---LMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASG--PSKKTAKLHVAVKVLQAMGYPTGFDADIECMSSDEKSDNESKNETVSSNSSNNTGNSTTETSSTLEVRTQGP----------ILTAS-GKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNK--KVAKASAALAALEKLFSGPNAANNKKKKIIPQ-------------------AKGVVNTAVSA-----------------------AVQAVRGRGRGTLTRGAFVG---ATAAPGYIAPGYGTPYGYSTAA--PAYG------------------------LPKRMVLLP--VMKFPTYPVPHYSFF------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q91WM1-1", "uniprot_id": "STRBP_MOUSE", "id": "Q91WM1-1", "name": "Spermatid perinuclear RNA-binding protein", "aln": "----------------------------MRSIRSFANDDRHVMVKHS------------TIYPSPEELEAVQNMVSTVECALKHVSDWLDET--------NKGTKPEGETEVKKDEAVENYSKDQG--------GRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCINEASIIIRNTKEPTLTLKVILTSPLIRDELE----KKDGENVMMKDPPDLLDRQK-----CLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKS--------IGTCNRPLGAGEALRRVMECLAS--GILLPGGPGLHDPCERDPTDALSY---------MTTQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSK--PFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKKMKRNLRK-ILDSKAID---LMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASG--PSKKTAKLHVAVKVLQAMGYPTGFDADIECISSDEKSDNESKNDTVSSNSSNNTGNSTTETSSTLEVRTQGP----------ILTAS-GKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNK--KVAKASAALAALEKLFSGPNAANNKKKKIIPQ-------------------AKGVVNTAVSA-----------------------AVQAVRGRGRGTLTRGAFVG---ATAAPGYIAPGYGTPYGYSTAA--PAYG------------------------LPKRMVLLP--VMKFPTYPVPHYSFF------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JKU6-1", "uniprot_id": "STRBP_RAT", "id": "Q9JKU6-1", "name": "Spermatid perinuclear RNA-binding protein", "aln": "----------------------------MRSIRSFANDDRHVMVKHS------------TIYPSPEELEAVQNMVSTVECALKHVSDWLDET--------NKGTKPEGETEVKKDDAVENYSKDQG--------GRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTVKDNLPIQIQKLTEEKYQVEQCINEASIIIRNTKEPTLTLKVILHSPLIRDELE----KKDGENVMMKDPPDLLDRQK-----CLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKS--------IGTCNRPLGXGEALRRVMECLAS--GILLPGGPGLHDPCERDPTDALSY---------MTTQQKEDITHSAQHALRLSAFGQIYKVLEMDPLPSSK--PFQKYSWSVTDKEGAGSSALKRPFEDGLGDDKDPNKRMKRNLRK-ILDSKAID---LMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASG--PSKKTAKLHVAVKVLQAMGYPTGFDADIECMSSDEKSDNESKNDTVSSNSSNNTGNCTTETSSTLEVRTQGP----------ILSSQQVAKILCGANEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNK--KVAKEVQR--TLEKLFSGPNAANNKKKKIIPQ-------------------AKGVVNTAVSD-----------------------AVQAVRGRGRGTLTRGAFVG---ATAAPGYIAPGYGTPYGYSTAS--PAYG------------------------LPKRMVLLP--VMKFPTYPVPHYSFF------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M2B247-1", "uniprot_id": "A0A8M2B247_DANRE", "id": "A0A8M2B247-1", "name": "Spermatid perinuclear RNA-binding protein", "aln": "----------------------------MRSIRSFGNDDRHVMAKHS------------TIYPSSEDLEAVQSLVSTVECALKHVSDWMDQSQASQSNPTNASSTQEEETEPTVDESPEGSTNEESSCSSGPSEGGVLCGVMRIGLVAKGLLIKDDMDLELVLMCRENPTKTLLSTVCEHLPQQIEKLTEEKYEVQQCIPEAAILVCTTTEPKLTLKVTLTSPQFKDDCE----TEEQESVESSEPADLLDRQR-----CLVALASLRHAKWFQARVNGLKSCVIVLRILRHMCNRVPAWEPLKGWPLELICEKA--------IATCNRPLGAGEALRRVMECLAS--GILLPGGPGLHDPCEKEPTNTLSA---------MTDEEAEAITSNAQHALRLMAFGQIYKVLDMDPLPSSK--PSQKYPWS--DKEGLG---LKRPYEDGLMDDKDLIKKMKRNLRKAVLDSKAIDSNQPMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTVYEASG--SSKKTAKLHVAVKVLQAMGYPTGFDTDLDSMSADEKSDGEGKSES-STHSSNNT-THSSDSSNTLEVRTQGP----------ILTAS-GKNPVMELNEKRRGLKYELISESGGSHDKRFVMEVEVDGQKFRGAGPNK--KVAKASAALAALEKLFSGPNAAGNKKKKIIPQ-------------------SKGALAAAAAVSAV--------------------AVQAARGRGRPTLTRGAFVS---AAAAPGYVTPGFGAPYGYSAAAATPAYGGL----------------------FIDNPFYQPRTIAPFFIHLGPQDLFSDF----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q86BI3-1", "uniprot_id": "Q86BI3_DROME", "id": "Q86BI3-1", "name": "", "aln": "MANNNYAGFNYGGTQYNTGQVSYPAVTNATYANAAAYQNAAVAAGQGGYGGAAGAGAGATSGPGAGGYGGYGDYRSAMQYDATKTFYQQSPASYNASGSTASVSKTHYSAPPVKNQVKGKMDKSNGG-----PKPPSSAPPAGNNYSGYDTALYNAASMYVAQQHQGNPNQKPNGGANNWYQRKMGATIPGATAIRGMRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDVTCTGTDAYAAHVRGAK-HQKVVKLHQKLGKPIPSEEPKKMGKINFVPAAAGGAGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEARANRAMMSSHRGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFG--RMGNGPPPHFGMMPGGNVRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIVLDESVSVKITLTSPLLRDANPGEAATTDEGEGDSEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLINGPGLLDPCEKDPTDALLELTKQEREDLTVSAQLFLRYIAFRQIYKVLGMEPLPAMKFPMRPWRVNRKRRRSSGKAGGAPGTETESNDIDETGSDEKVAKKEGVGGTPAST", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: . :: * . :. * *.. . . *::: .:. . : :. . .: :: :.:. . . . . : : .: :. : :*.:. . . : :: :. :*. : . ::. * .: .: . ..: ::: * . .: :. : *:..* * *::: :.: : :*: * * :::: : . .*.. . *: .: :.*.. . : * * : : : . ** : * . :* *: * *:::.* * .: . : : ... * :*: : : :. : : . .:: :. *. : ** : : ..:. ** . .: . :: *:. *::. ..* :* . : . .:.*...:. :.::* . ...:.* . * : :: .: : :.* .*. : .: :**:.: : . . *:: : :... .: ..:::*: :.* . *: . . . .:: * : : :.*:: * * . . . : . * * ", "identical_positions": 58, "similar_positions": 242, "identity": "6.5%" }, { "cls_id": "homologset.agr.HGNC:16463", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R1C7-1", "uniprot_id": "PR40A_MOUSE", "id": "Q9R1C7-1", "name": "Pre-mRNA-processing factor 40 homolog A", "aln": "-----------------------------------------------------------------------------MRPGTGAERGGLMVSEMESQPPSRGPGDGERRLSGSNLCSSSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPP-MGGPPMGQMPGMMSSVMSGMMMSHMSQASMQPALPPGVNSMDVAAGAASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGGLITKSNLHAMIKAEESSKQEECTTASTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAA---NANTSTTPTNTVG-SVPVAPEPEVTSIVATAVDNENTVTVSTEEQAQLANTTAIQDLSGDISSNTGEEPAKQETVSDFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIIN-DPRYSALAK-LSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWN--AISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWSEAQQYLMDNPT-----FAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKTLLRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQP----GSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVVEVN----TTFEDFVAIISSTKRSTTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRERFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSESDDDDSHSKKKRQRSESHSASERSS-SAESERSYKKSKKHKKKSKKRRHKSDSP-------------ESDTEREKDKKEKDRDSEKDRSRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZVY5-1", "uniprot_id": "A0A8I5ZVY5_RAT", "id": "A0A8I5ZVY5-1", "name": "Pre-mRNA-processing factor 40 homolog A", "aln": "MQATPSEAGGESPQSCVSVSRSDWTVGKPVSLLAPLIPPRSSGQPLPFGPSGRQPLRSLLVGMCSGSGRRRSSLSPTMRPGTGAERGGLMVSEMESQPPSRGPGDGERRLSGSNLCSSSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPP-MGGPPMGQMPGMMSSVMSGMMMSHMSQASMQPALPPGVNSMDVAAGAASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLE------------------AMIKAEESSKQEECTTTSTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAA---NANTSTTPTNTVG-SVPVAPEPEVTSIVATAVDNENTVTASAEEQAQLANTTALQDLSGDISSNTGEEPPKQETVTDFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIIN-DPRYSALAK-LSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWN--AISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWSEAQQYLMDNPT-----FAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKTLLRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPVFSLGSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVVEVN----TTFEDFVAIISSTKRSTTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRERFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDDDSHSKKKRQRSESHSASEHSS-SAESERSYKKSKKHKKKSKKRRHKSDSP-------------ESDTEREKDKKEKDRESEKDRSRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75400-1", "uniprot_id": "PR40A_HUMAN", "id": "O75400-1", "name": "Pre-mRNA-processing factor 40 homolog A", "aln": "-----------------------------------------------------------------------------MRPGTGAERGGLMVSEMESHPPSQGPGDGERRLSGSSLCSGSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPP-MGGPPMGQMPGMMSSVMPGMMMSHMSQASMQPALPPGVNSMDVAAGTASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGSLITKSNLHAMIKAEESSKQEECTTTSTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAAAAANANASTSASNTVSGTVPVVPEPEVTSIVATVVDNENTVTISTEEQAQLTSTPAIQDQSVEVSSNTGEETSKQETVADFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIIN-DPRYSALAK-LSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWN--AISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWSEAQQYLMDNPT-----FAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKSLLRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQP----GSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVVEVN----TTFEDFVAIISSTKRSTTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQAAPPIELDAVWEDIRERFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDDDSHSKKKRQRSESRSASEHSS-SAESERSYKKSKKHKKKSKKRRHKSDSP-------------ESDAEREKDKKEKDRESEKDRTRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VQK5-1", "uniprot_id": "Q9VQK5_DROME", "id": "Q9VQK5-1", "name": "", "aln": "----------------------------------------------------------------------------------------------MNVPPSVGNGGAP-----------------------PGR---GIGYTP---------------PGAIVPQFPPPGFGAPPP-------------------------PELAAAFGVMATST--------EWTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPWKEYRSDTGKVYYHNVATKETCWEPPPEYVDMK------------------AKAKAEEAAAAAKAVAAMTS-----------SSLAGMVPPAALASILPAALPVA-------------------PRLPTPEIHSPLTPSS-NEN--SSSAMDQAMAATLAAIE-----------------------VPQQNAKKDDKSESAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISK-DPRYAAFKN-LNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWT--AVPEPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVA-----FKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFSAMLGQS----GSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAK----TSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEAN--VSVAEPYESAKKLVEHLEAFALYEKEIGVEKIWEDFVKESEDACSHHHSRSRKSKKNKKHKKRVRSVSRSDIENEHIEVE-KSKRRRSKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSCESDVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNEELTLSDGELESKRAALLAQLSEQLDE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P33203-1", "uniprot_id": "PRP40_YEAST", "id": "P33203-1", "name": "Pre-mRNA-processing protein PRP40", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSIWKEAKDASGRIYYYNTLTKKSTWEKPKELISQEELLLRENGWKAAKTADGKVYYYNPTTRETSWTIP-------------------------AFEKKVEP--------------------------------------------------------------------IAEQKHDTVSHAQVNGNRIALTAGEKQEPGRTINEE--------------------------ESQYANNSKLLNVRRRTKEEAEKEFITMLKENQVDSTWSFSRIISELGTRDPRYWMVDDDPLWKKEMFEKYLSNRSADQLLKEHNETSKFKEAFQKMLQNNSHIKYYTRWPTAKRLIADEPIYKHSVVNEKTKRQTFQDYIDTLIDTQKESKKKLKTQALKELREYLNGIITTSSSETFITWQQLLNHYVFDKSKRYMANRHFKVLTHEDVLNEYLKIVNTIENDLQNKLNELRLRNYTRDRIARDNFKSLLREVP--IKIKANTRWSDIYPHIKSDPRFLHMLGRN----GSSCLDLFLDFVDEQRMYIFAQRSIAQQTLIDQNFEWNDADSDEITKQNIEKVLENDRKFDKVDKEDISLIVDGLIKQRNEKIQQKLQNERRILEQK-----------------------------------------------KHYFWLLLQRTYTKTGKPKPSTWDLASKELGESLEYKALGDED------NIRRQIFEDFKPESSAPTAESATANLTLTASKKRHLTPAVELDY---------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.* * ..** **** **:*:****. * : * * : ** :: ** **:* *:*: * * * * *. : . :: * * : :: :: : :. .: . *.** : * :*::..* *. .:.: :. : . **** . . :*: *: * : :: : : : .: ** ::::* . .::. :: .:.::. :. .: * : : ::* : * . :**. : *:.: : * : *:.: . . : *: * * . : : : : :**.* : : :.::*:: ::: :. * ::* *:.* :* .: :: : : * ::** *.:* ** ***: **: **** :*:: : . ::.* :: * :: * : : ::: :: . :: .:* ::.* :.*::: : ::: ::* * :.: :.:. . : .: : . . :. .* . . .:. . *:: . * : ** . . *:: : * ", "identical_positions": 104, "similar_positions": 207, "identity": "9.74%" }, { "cls_id": "homologset.agr.HGNC:16465", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VDI1-1", "uniprot_id": "ESIP1_MOUSE", "id": "Q8VDI1-1", "name": "Epithelial-stromal interaction protein 1", "aln": "MYTRSKVVGPGLGTSSISRDHAG----AGQRRELGLQQNRRQSLEVAAPEGPKMERQGHADQGSAGTYTLIAPNESRRQKIQRIAEQELADLERWKQQNRAKPVYLVPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDESIRIRKEAEEAKFQKMKAIQREKSNKLEEKKQLQEDIRRATFREHHQSKTAELLSRLDTERRNRSACLIAPPATQSSRWKLPVLLRDPSWAGSQAHRDSPQKEDNPRLQKTRDG-HQKNKLLETKGQHQEEERAQIHQAEHWRVNNAFLDRLQG--------------------------KSQPGGLEQSGGCCNMNSTDS--------WGL-----------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5BK43-1", "uniprot_id": "ESIP1_RAT", "id": "Q5BK43-1", "name": "Epithelial-stromal interaction protein 1", "aln": "MYPRSRVVGPGLGTSSSSRDHAG----AGQHGELDLQQNQRQNLEVAEPKGPKLERQGHGDQRSTGTYTLIAPNETRRQKIQRIAEQELADLERWKQQNKAKPVHLVPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDEAIRIRKDAEEAELQRMKAIQREKSNKLEKKKQLQEDIRRATLREHHQSKTAELLSRLDTDRTNRSACNIAPPAAQSSRWKLPVLLRDPSRAGSQAHKDSPQKEDNQKLQKTRDG-HQKNKLLETKGQHQEEERAQIHQAEHWRVNNAFLDRLQG--------------------------KSQPGGVEQSGGCWNMNSTDG--------WGI-----------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96J88-1", "uniprot_id": "ESIP1_HUMAN", "id": "Q96J88-1", "name": "Epithelial-stromal interaction protein 1", "aln": "MNTRNRVVNSGLGASPASRPTRDPQDPSGRQGELSPVEDQREGLEAA-PKGPSRESVVHAGQRRTSAYTLIAPNINRRNEIQRIAEQELANLEKWKEQNRAKPVHLVPRRLGGSQSETEVRQKQQLQLMQSKYKQKLKREESVRIKKEAEEAELQKMKAIQREKSNKLEEKKRLQENLRREAFREHQQYKTAEFLSKLNTESPDRSACQSAVCGPQSSTWKLPILPRDHSWARSWAYRDSLKAEENRKLQKMKDEQHQKSELLELKRQQQEQERAKIHQTEHRRVNNAFLDRLQG--------------------------KSQPGGLEQSGGCWNMNSGNS--------WGI-----------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B640-1", "uniprot_id": "A0ACD6B640_DANRE", "id": "A0ACD6B640-1", "name": "", "aln": "MNHYKHPRRNAVERGGYRRHTIN---------QRNNMTDSGQTNNNECPNSSPGTSNPQNQPEHAGGFTKIPPNESRRSKLLSISQKGEENLRRLKEENRPGPIHLPPERLGGNVSLEEVRQKQWVNARNSKIEKKVKKEEMDKMKRQAEEETNEKMKAKQREKANKLEMRKKQEDERRKQQHQQDKQKKTEEFLQRFE-----RSSSTVSMAASNS--------IPASPWTKCHEYRESRRAEENASLLKMQEEQRRKAAILEEKQKQQEEDRKRQTEADHRRVNSAFLDRLEASGSGVRVSEPVTQTLESSNVWLEEDDEPQDTALSTSRNPSQVHTDSAEEDDGDYTWTVMKLQNRFPDFKRDMLEDIVIQCNGNYKKAFELLNV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* .: .: . * . : . : : : *:.. : :. :* *.** .**.:: *::: :*.: *::*:. *::* *.****. * ****** :: .** ::*:*::* :::::*** ::*** ****:**** :*: ::: *: ::.:* ** *:*.::: **:. : ..:* . : . :::* : *:* * * :: ::* :** * ::**::* : :::* ***.******:. :.* .:. * . :::: .. * : ", "identical_positions": 81, "similar_positions": 111, "identity": "20.88%" }, { "cls_id": "homologset.agr.HGNC:16466", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A606-1", "uniprot_id": "A0A8I6A606_RAT", "id": "A0A8I6A606-1", "name": "Suppressor of fused homolog", "aln": "MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKR---------ETGES--APPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTYDRAPSRKDSLGSDISTAVIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPE--EFKLPKEYSWPEKKLKVSI------LPDVVFDSPLH-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0P7-1", "uniprot_id": "SUFU_MOUSE", "id": "Q9Z0P7-1", "name": "Suppressor of fused homolog", "aln": "MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKR---------ETGES--APPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPE--EFKLPKEYSWPEKKLKVSI------LPDVVFDSPLH-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UMX1-1", "uniprot_id": "SUFU_HUMAN", "id": "Q9UMX1-1", "name": "Suppressor of fused homolog", "aln": "MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKR---------ETGES--APPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPE--EFKLPKEYSWPEKKLKVSI------LPDVVFDSPLH-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VG38-1", "uniprot_id": "Q9VG38_DROME", "id": "Q9VG38-1", "name": "Suppressor of fused homolog", "aln": "MAEANLDKKP-EVKP---------------PPGLKAIIDHLGQVYPNQPNPLQVTTLLKYWLGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGLSDLHGDERVHLREEGVTRSGMGFELTFRLAKTEIELKQQIENPEKPQRPPTWPANLLQAIGRYCFQTGNGLCFGDNIPWRKSLDGSTTSKLQNLLVAQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASRWNGRGVLNFLRQDMQTGGDWLVTNMDRQMSVFELFPETLLNLQDDLEKQGSDLAGVNADFTFRELKPTKEVKEEVDFQALS--EKCANDENNRQLTDTQMK----REEPSFPQSMSMSSNSLHKSCPLDFQAQAPNCIS-------------LDGIEITLAPGVAKYLLLAIKDRIRHGRHFTFKAQH--LALTLVAESVTGSAVTVNEPYGVLGYWIQVLIPDELVPRLMEDFRSAGLDEKCEPKERLELEWPDKNLKLIIDQPEPVLPMSLDAAPLKM", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** . . * . * ****:** .. ::**:********:::****** *****:***. *. . *:* ************:**:*** **:******** : *. *. ******:*:*.:.** **: * :* **::.*:..** .: *::*::*:::***: : ** *.* * ***** :**..*.:***:*:*::** :** **:*:* * ::**: *. .::..:*.:**:*:**.*. :: :*. . * .*: .:. : ..::..*: :* : ..:* :* . .*.* . . . : . . * *:.:.:.: . : *.::.*: ******:*: :*:*:*: .* *: .* :.**.. * *:*:*:.:*:* :::**:.. * * * * .**:*:**: * ** : :**: ", "identical_positions": 179, "similar_positions": 155, "identity": "35.45%" }, { "cls_id": "homologset.agr.HGNC:16467", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K2H4-1", "uniprot_id": "ACAP1_MOUSE", "id": "Q8K2H4-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "aln": "MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSCLLESGQHYLAAGRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALRTARAGYRSRALDYALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKK-YKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPA-PEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCE--LGNVIINQIYEARV-EAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRGPPR---------------------GHPPVPPKPPIRP------------------------------------------------HSGIVRSKSECPSDDMGSLHPG---------ALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETT---NADIVTLLRLAKMREAEAAQGQAG--DETYLDIFRDFSLMASDDPEKLSRRSHDLHTL-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ABD3-1", "uniprot_id": "D4ABD3_RAT", "id": "D4ABD3-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "aln": "MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGSCLLESGHHYLAASRAFVVGICDLAHLGPPEPMMAECLEKFTESLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAESLEAALSHNAEVPRRRVQEAEDAGTALRTARAVYRSRALDYALQVNVIEDKRKFDIMEFILRLVEAQATYFQQGHEELNQLAQYRKELGAQLHNLVLNSARERRDMEQRHVLLKQKELGGEEPEPSLKEGSSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKK-YKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHSPGSAATLSCGGPARGREPGGVGQVAAQVQSVDGNAQCCDCKEPA-PEWASINLGITLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCE--LGNVVINQIYEARV-EAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRGPPR---------------------GHPPVPPKPSIRP------------------------------------------------QSGIVRSKSESPSEDIGSLHPG---------ALLFQAAGYPPSLPTMADALAHGADVNWVNAGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETT---NADIVTLLRLAKMREAEAAQGQTG--DETYLDIFRDFSLMASDDPEKLSRRSHDLHTL-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15027-1", "uniprot_id": "ACAP1_HUMAN", "id": "Q15027-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "aln": "MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVLLKQKELGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKK-YKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPA-PEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCE--LGNVIINQIYEARV-EAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRGRPR---------------------GQPPVPPKPSIRP------------------------------------------------RPGSLRSKPEPPSEDLGSLHPG---------ALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETA---NADIVTLLRLAKMREAEAAQGQAG--DETYLDIFRDFSLMASDDPEKLSRRSHDLHTL-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VCQ6-1", "uniprot_id": "Q9VCQ6_DROME", "id": "Q9VCQ6-1", "name": "", "aln": "MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR--------YCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHS-----------RPQSTNAPNNSLPAKRR------IHWEEFLKIPGNAYCCDCRSPE-PRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMME--LGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQE---NADIVTLLRLTQLNDEIGPNDEYNGEDETYKNVMKDFSKLPASQTRVLRQR-HDSNTLESQRSSLTNSD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04412-1", "uniprot_id": "AGE1_YEAST", "id": "Q04412-1", "name": "ADP-ribosylation factor GTPase-activating protein effector protein 1", "aln": "-MDFYTTDINKNVVPLFSKGTVARTASKAQYPSWCNNALKLTNILLKSLR-------------CKFQTNRCED-------DRGFEVYCVILKSIALLMAAKESLILLQIPPSLPSGFP-----------------------------------------------FRSPQLSFTYLSTRLS------------------------GSQHKSTHSHHINHQTHPIHSSSSNSNSNNR--------------------IPTKTDSSKQHTQHFSFANAG------------------------------ASNRDELLSIVRKIDKS---------------------------------------------------------------------------------------------NLKCCDCGSTATVEWVSINLLCILCIKCSGVHRSLGSHISKIRSLTLDNFTSLELMHLLQNNVSNSNVNAIYESNL-RNFPVKKITANSDDSERSKFIIDKYQFKKFVIDSNQGR------------------------------------------------------------------------------------------------------------------EASLKSLIKAIHLDSVFMMQR-------------AIAQSKYSLRELTASEKEQNDLNHSSIFQYSLKHYEIVDGTPIFFITEFLLCNGIHIDNLPKITTNWSPKVLEYWETKLEMYGTFQAVNTSRPRSGPHLNMHSNVDSASSYNKKHDLRVNIPERSASASKRWSLSSIPKSSQNLMSPTNLLTMHKSLKLAKKDKK---------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * * :. . :: :** . :.* : .: : : . : *: . : :: : ..: :: *.:. . . * : . .. :. :: : .: . .. : . * . . . * :. *: .. * **** .. .*.**** ***:***:***** * **:****** : . : : : :.* :* ***:.: :** ... :. :* ** ::*: : : . : * : : : .* : : * . : . . . : .: **** ** :: . . . : . . : : : :: * . :.:.: . . . . :: ::: . :. .. * :: :. ", "identical_positions": 63, "similar_positions": 141, "identity": "7.33%" }, { "cls_id": "homologset.agr.HGNC:16468", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZFJ6-1", "uniprot_id": "D3ZFJ6_RAT", "id": "D3ZFJ6-1", "name": "Serine beta-lactamase-like protein LACTB, mitochondrial", "aln": "MYRFLSSVTSRATATAGPALGGGRRGAHGRPGLPMLSLGWAGGLGLGLGLALGAKLAIGLRGAVPIQSPADP--EASGATELPHEQAPGPGSPHTPASPAARGFSRAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDLPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDMKKVKEEKAYKALKMMKGTPPP-DQEKELKEKGGKDNDKSDSPKAKAEQDSEAKCRSAKPGKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERTSGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVEKKQTHGACRKQRHYASHTGGAVGASSVLLVLPEELDPEAVNNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRAD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EP89-1", "uniprot_id": "LACTB_MOUSE", "id": "Q9EP89-1", "name": "Serine beta-lactamase-like protein LACTB, mitochondrial", "aln": "MYRLLSSVTARAAATAGPAWDGGRRGAHRRPGLPVLGLGWAGGLGLGLGLALGAKLVVGLRGAVPIQSPADP--EASGTTELSHEQALSPGSPHTPAPPAARGFSRAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDLPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMVKGTPPPSDQEKELKEKGGKNNEKSDAPKAKVEQDSEARCRSAKPGKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGQFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVEKKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDSEAVNNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRAD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83111-1", "uniprot_id": "LACTB_HUMAN", "id": "P83111-1", "name": "Serine beta-lactamase-like protein LACTB, mitochondrial", "aln": "MYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMMK------ENVAFEQEKEGKSNEKNDFTKFKTEQENEAKCRNSKPGKKKNDFEQGELYLREKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGCKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVERKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDTETINNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRSD", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***::*:**:**:*..* * . ****.* *.*** *. **.************.**. *****.* **** * *** :* .:**: .* **:***.*.:* *:*********************************************************************************:***************************************:**************:* :: :** **.*:*.* .* *.**:.**:**.:****************:******************************************:** ******************************************************************************** **********************************************:***:*:*****************************.*::*************************************:*", "identical_positions": 471, "similar_positions": 50, "identity": "85.17%" }, { "cls_id": "homologset.agr.HGNC:16469", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5FVC7-1", "uniprot_id": "ACAP2_RAT", "id": "Q5FVC7-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "aln": "MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCAANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFK-DSPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL-EKMGVKKPQPGQ-RQEKEAYIRAKYVERKFVDKYS------TLLSPSEQEKRIIS--------------KSCEDQRLS--------HTRVSVHTP------------------VKSNDSGIQQCSDDGRESLPSTVSANS----------------------LYE---PEGERQE-----SSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQ----DSQKF------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZQK5-1", "uniprot_id": "ACAP2_MOUSE", "id": "Q6ZQK5-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "aln": "MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFK-DSPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL-EKMGVKKPQPGQ-RQEKEAYIRAKYVERKFVDKYS------ALLSPSEQEKRIIS--------------KSCEDQRLS--------HARASVHTP------------------VKSNDSGIQQCSEDGRESLPSTVSANS----------------------LYE---PEGERQE-----SSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQ----DSQKF------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15057-1", "uniprot_id": "ACAP2_HUMAN", "id": "Q15057-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "aln": "MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFK-DNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANV-EKMGIKKPQPGQ-RQEKEAYIRAKYVERKFVDKYS------ISLSPPEQQKKFVS--------------KSSEEKRLSISKFGPGDQVRASAQSS------------------VRSNDSGIQQSSDDGRESLPSTVSANS----------------------LYE---PEGERQD-----SSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQ----DSQKF------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B8JLA1-1", "uniprot_id": "B8JLA1_DANRE", "id": "B8JLA1-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "aln": "MKVTVDFEECLKDSPRFRATIEDVEEDFGELESKLDKLVKLCIGMIDAGRVYNQANKQFVNGIRDLALQSTRDEVIGSSLAAFSETLQEMNNYHTILFDQAQRSIRSQLQTFVKEDLRKFKDAKKQFDKVSEEKEVALVKNAQVPRNKLHEVEEATNILTTTQKFFRNIALDYVLQINVLQSKRRLEILKSMLAYMNANLTFFNQGHDLFSQLQPLMKQLSGQLDQLVVDSAKEKRDMEQKHSSIQQKAALQDFSTEDSKLEYNIDTDNGIAMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKRFR-DNPTVVVEDLRLCTVKHCEDVERRFCFEVLSPSKSCMMQADSEKLRQAWIKAVQSSIASAYRENEDEIISLDRQSSASLGSLDSGCES-VKLVKGESALQRVLAIPGNEFCCDCGQSDPRWASINLCITLCIECSGIHRSLGVHNSKVRSLTLDTWEPELLKLMCELGNDVINQIYEAHR-EENGGKKPQPGDPRREIEAFIRAKYVDKRFVLKPTEQEQMEKIMTLRKHDKRMQGNMEFLPPRPPPPTPKLRTASNASVASLSGQEVRRDSLFCPDELDSLFSYFDTSSKLQNLKRADSGIQNSADGSREMLASTPSSSS----------------------LSETDLPESEAAANQAERSPVFSKLTNFSADSLLYWASCACSLKDMAQALAHGADINWVNLEDSSRTPLIQAVQGGSLISCEFLLQNAACVDQQDIRGRGPLHHATILGHTGQVCLFLKRGAKQNTVDTDSRSPLSIAVEAANADIVTLLRLAKMNEEMRGSEGAFGQAGQYSLSQSHTEQ-QYKKCIQEFISLHLQ----ES---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VCQ6-1", "uniprot_id": "Q9VCQ6_DROME", "id": "Q9VCQ6-1", "name": "", "aln": "MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRY------------CDSNTNSTS-NKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNN-SLP---------AKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQ---ELLASETAEVLSIDSGGVVEDGE---SGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAE----SPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPASQTRVLRQRHDSNTLESQRSSLTNSD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: *::************ :.. * *. .** :*:*::*** :*:*: : :. * .: ** : .:* : . :*** ::****:**:.*:: :*. ***:*:.:.** * :* **** : **:****. :*: :*::**:***::::. *:: ***** *.: *::: .**.::* : * :::::**.** .:: :*::. :*: * * : :: *:::* :::: : * :: . :******: *:.**** **** :.:.****:*: . *. :*: ****:*:*: :: :*******:**:** ::**** .: . **.*:* **.:* :.. . : .:.. ** * . :.. **** **** .:******** *********:******* *********:**.* :*:* ****:*:*::***. :. * *** **:*:****:::** . :: : . .. : . .. ::: :. :.* : * : .:.* *. .::... ** ** .* *. *:* *** * * :: . : * *** .**:::***** *.* :: * * ..** :* ** .** *:**: * . . :.:..*.***: **********:::*:*: .: *: : : .: : : . : : :* ", "identical_positions": 270, "similar_positions": 236, "identity": "31.29%" }, { "cls_id": "homologset.agr.HGNC:16470", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8IFW4-1", "uniprot_id": "THIOT_DROME", "id": "Q8IFW4-1", "name": "Thioredoxin-T", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVYPVRNKDDLDQQLILAEDKLVVIDFYADWCGPCKIIAPKLDELAQQYSDRVVVLKVNVDENEDITVEYNVNSMPTFVFIKGGNVLELFVGCNSDKLAKLMEKHAGVYTDEAADVKAVHIDGECIVDLTAESSESDNDNNNVNEVSAHDENAVLEH", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9V429-1", "uniprot_id": "THIO2_DROME", "id": "Q9V429-1", "name": "Thioredoxin-2", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVYQVKDKADLDGQLTKASGKLVVLDFFATWCGPCKMISPKLVELSTQFADNVVVLKVDVDECEDIAMEYNISSMPTFVFLKNGVKVEEFAGANAKRLEDVIKANI---------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47938-1", "uniprot_id": "THIO1_DROME", "id": "P47938-1", "name": "Thioredoxin-1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASVRTMNDYHKRIEAADDKLIVLDFYATWCGPCKEMESTVKSLARKYSSKAVVLKIDVDKFEELTERYKVRSMPTFVFLRQNRRLASFAGADEHKLTNMMAKLVKA-------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q6P902-1", "uniprot_id": "TXND2_MOUSE", "id": "Q6P902-1", "name": "Thioredoxin domain-containing protein 2", "aln": "--------MTLNNGGKANER----GSNENPLQALSKNEAFLVP------------EFLDTAQSKEKAIASKVSNTLHMSTEESEFPQQVSSTPMFSENTVHPRHEVSPKPSSKNTQLKQENISKSSGYSKQTNYSNTPKSLAKTTHPKQGSTLKPATNSTHYREDDIPKSSEDIIQPKKGDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQPKKEDRPKSSEDSVPSKKGDRPKSSEDSVQPKKEDRPKSSEDSVQSKEGEVHKPLKDSIQSKETKVPKSPQDSIQSKEDKTHRPLKDSVQSKESEEPKSSHESIQSKE-DKIHKP--------------LKDSIPSKE-------------GDIPKSPEDTIQSQE-EITASEEDTIQSQEGNTIKSSEEDVQLSESKLLGLGAEIETLEEG-LVRVIKDKEEFEEVLKDAGEKLVAVDFSAAWCGPCRMMKPLFHSLSLKHED-VIFLEVDTEDCEQLVQDCEIFHLPTFQFYKNEEKVGEFSGALVGKLERSISELK---------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5XHX6-1", "uniprot_id": "TXND2_RAT", "id": "Q5XHX6-1", "name": "Thioredoxin domain-containing protein 2", "aln": "--------MFKKNQKLSKDK----GLEVNSVQAGAPEESDVKLNNGGKANERGSNEFLDTAQSKEKVIASVVGNMLHMSTEESEPPQQVSSTSMFSENTIYPKHEGSPKSSTKNTQLKQEDISKTSSYSKQTNSSNIPKSLAITTYPKQGSTLKPAANGTHDREAEKPKSSEDLIQSKKGDIFKPSEDSIQSKKGDMPKSSEDPIQSKKDDTAKSLEDTIQSKNGDMPKSSEDPIQSKKDDTARSLEDSIQSKKGDMPKSS-DTIQSKESETPKFLQDTIQSKGGKINKQVKDSMKSKESKIRKPLKDSIQSKENKIPKSSQDSAQPKEGKIHKPLKDSLPSKEGDISKPSEDTIQAKE-EITVSPEDTIQAKE-EITMSPEDTIQAKEEITVSPEDTIQAKEEITVSPEDTMQSKE-EITVSPEDTVQSQEGD-IKSSE-DVQPSENEIFPFEAEIETLEEG-MVRVIKDKEEFEEVLKDAGEKLVAVDFSAPWCGPCRKMRPHFHSLSLKHED-VIFLEVDTEDCEQLVQDCEVFHLPTFQFYKNEEKVGEFSGALVEKLEKSIAELK---------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q86VQ3-1", "uniprot_id": "TXND2_HUMAN", "id": "Q86VQ3-1", "name": "Thioredoxin domain-containing protein 2", "aln": "MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSN---VPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKE-------------GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHED-VVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK---------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : . : * :*:.:** * *****: : . . *: :. . .:.*:::.:. *::. : :*** * : : : *. :* : ", "identical_positions": 19, "similar_positions": 37, "identity": "3.06%" }, { "cls_id": "homologset.agr.HGNC:16471", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GEU7-1", "uniprot_id": "A0A8I6GEU7_RAT", "id": "A0A8I6GEU7-1", "name": "", "aln": "MDLEVKGVAAA-RSQTQLYSGRKNSLKQGWTSRSWAIQNSCLPMVPPLDLGSLVDSDEEDKFSPAPRGTVH---DAPRSQPTLSYIMPCQRPYIQHHLNEAEQDTIPEDLPAPTGKYKLKYQQYASEMKDGYKQYIQRSAEKPKP----GKGP-----EANKKVEGACLDDLITLDRKALLQQGYADSPYHRRSSAKKSDVETVALEKKRQTVAEQMMVDHLSRAVISDPEQDLNTKNQESSHVPPDSERAPLRVRRRTLHETKIRTNSTLTENDLSQKVEFEGRVLSRNGRDACRELIGFFFAHDQSLTVYEYRMFGKNRTSVLPFIKKDVYCHQYGQRKGEQYELGDFYTGATLTFLSCDHPSLPKSIKENALLRLRITSIDQVALDSLKAASAEPGREDPVSQEAQDQLVLQAIQEKLKEQLHTKGVRILTGLGKYFQRLDKEGNGLLEKTDFQQALETFHLEVSEQDFESSWLILLGHGHSQNKVDYGEFKRAIFGEMNEYRKSFVRKAFMKLDFNKTGTVSVIDIRKCYCAKKHPRVISGHSTEEEIKSSFLETLKDACSKPDEVSYGEFEDYYEGLSVGIAGDEDFVNILCTPWGI-------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BUG5-1", "uniprot_id": "CAYP2_MOUSE", "id": "Q8BUG5-1", "name": "Calcyphosin-2", "aln": "-------------------------------------------MVPPLDLGSLVDSDEEDNFSQTARGTVHVHLNPPRSEPALGWVLPCQRPNSQHRLQEVEQDVIPEDLPAPTGKYRLKYQQYASEMKDGYKQYIQRSTEKPKA----ASRP-----EATEKVEGASLDDLMTLDRKALLQQGYADSPYGRQSITRKSDVETVAIEKKKQTVAEQMMMDHLSRAVISDPEQDLNTKNQESSRVPPDSERAPLRVRRRTLHETKIRTNSALTENDLSQKVEFDGRVLSRNGRDACRELIGFFFAHDQSLTVYEYRMFGKNRTSVLPFIKKDIYHHQCGRRKGKQYELGDVYTGATLTFLSCDQPSLPKTIKENALLRLRITNIDQVALNSLKAASAEHGEEEAVSPEAHDQLVLQAIQDKLKEQLHKKGARILTGLGRYFQGLDKEGNGLLEKADFQQALKTFHLEVSEQDFESFWLILQGYGHSKNKVDYGEFKRAIFGEMNEYRKSFVRKAFMQLDFNKTGIVSVIDIRKCYCAKKHPRVISGHSTEEEIKSSFLETLKGTCSKCDEVSYGEFEDYYEGLSIGVAGDEDFVNILRIPWRI-------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BXY5-1", "uniprot_id": "CAYP2_HUMAN", "id": "Q9BXY5-1", "name": "Calcyphosin-2", "aln": "MDLEVKGVAATSRSQIQPFFGRKKPLQQRWTSESWTNQNSCPPVVPRLDLGSLVDSDDEDNFSYIPLSTAN----LPNSSSTLGWVTPCQTPYTQYHLNKLDQNIIPENLPAPTDKCKLKYQQCKTEIKEGYKQYSQRNAENTKSNVTHKQSPRNKIDEKCVQDEEANTDDLTTLDRKAILQQGYADNSCDKQQRARKLDAEIVAAEKKKQIVAEQVMIDHLSRAVISDPEQNLAIEQKESDHILPDSKMTPLRFRKRTLHETKIRTHSTLTENVLSHKLQFDGRIVSRNGRDACRELIGFFFTHDQSLTIYEYRQFGKNRTNVLPFIQKSIYSHQCGRRKGKQYRLGDFYVGATLTFLSSDHLSLPESIKENTLLKLRITNIDQIALDSLKTASMEQ-EDDIIIQETNDRLVFKAIQDVLKEKLHKRGVRILTGLGKYFQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNG--KVDYGEFKRGIIGEMNEYRKSYVRKAFMKLDFNKSGSVPIINIRKCYCAKKHSQVISG----------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58HWL6-1", "uniprot_id": "A0AC58HWL6_DANRE", "id": "A0AC58HWL6-1", "name": "", "aln": "-------------MKANAKYSHLQKNDQQLHKMTGADRGSRPAEVPVLKLDALQNAEEEHLAIHVKDAGMK---IVSGDLSAMSWGSSASTPTKQCFPSKMKDLIQNQVALDDGESLQLSYRAQTQRSPQYSNKTSQHSPE-------------------------------------STCKNTAQTSFNALQVNSKMRDAEGLTEERKLQAVIEQVMVDQLSRAVISDPEQNAVSVSPTS--VPPR--------YRRTLHHTQVKTRMSLTENILSNKLCFQARILSRCGREACRKLIGFFFTCDQTMTIYEYRNFGKNRWNALPFIARGVYWN-----RGRPYCLQDISQGAELHFCTDG-PHFPQSLRQQPCLSLTVTDVDDGAKGALLAQSGET-LRHLSEEEINEQNTLKEMQGAVRDRLRGRAIQTLISLGRDMQKMFDLKADGVQQKELLRRSLMEQLCITAQDFEAVWRIVSRRMEG--RVNPADVMRAVTGEMNEDRKALFLKVYVKLDPNKTGSIFLSDIEKFYRGKQEADTALDP----RPNPDFLAFIQEAGKITKTVSYAEFEDYYEGPVHACYCACFWIFLSDWSCSQGSQQWNEPPAWKRYHLKVLRLCSSDRNSHIH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** *.*.:* ::::*. . : . . .::.: ... * * .: .: : . :*.*: . : :: *:..* : :: . : :: *.* :: *:* * * **:*:*:***********: . * : * :****.*:::*. :**** **:*: *:.*::** **:***:******: **::*:**** ***** ..**** :.:* : :*. * * *. ** * * : . :*::::::. * * :*.:*: * .:* : * * . * ::: .:: :* ::::*: :. : * .**: :* : . . ::: :: : :* :: :***: * *: .. :*: .:. *.: ***** **: . *.:::** **:* : : :*.* * .*:.. . . ", "identical_positions": 129, "similar_positions": 158, "identity": "20.38%" }, { "cls_id": "homologset.agr.HGNC:16472", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZR99-1", "uniprot_id": "D3ZR99_RAT", "id": "D3ZR99-1", "name": "", "aln": "MSGSNGPTDTRAYQSLAEDCPFGSAEQPKRSTGR-----------------LVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRARWGRRRPYILTLGVMMLLGMALYLNG-------------------------DAAVSALVANPRQK------LVWAISITMIGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWMHLELGKLLGTEFQVMFFFSALVLTLCFITHLCSIPEDPLRDDATDPPL-----------------------QPDPQGSSLSADGMPRYGSIEKVKNGDADTGLPVQG-GKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCISHLIGWTAFLSNMLFFTDFMGQIVYHGDPYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKVMVSYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYHREEEKEKQQEVPGGPDNHGRGKGVDCAALTCMVQLAQILVGGGLGFLVNMAGSVVVVVITASAVALIGCCFVALFVRYVD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P58355-1", "uniprot_id": "S45A2_MOUSE", "id": "P58355-1", "name": "Membrane-associated transporter protein", "aln": "MSGSNGPTDTHTYQSLAEDCPFGSVEQPKRSTGR-----------------LVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRARWGRRRPYILTLAIMMLLGMALYLNG-------------------------DAVVSALVANPRQK------LIWAISITMVGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYILGAIDWVHLDLGRLLGTEFQVMFFFSALVLILCFITHLCSIPEAPLRDAATDPPS-----------------------QQDPQGSSLSASGMHEYGSIEKVKNGGADTEQPVQE-WKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCVSHLIGWTAFLSNMLFFTDFMGQIVYHGDPYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKAMVSYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYHREEEKEKGQEAPGGPDNQGRGKGVDCAALTCMVQLAQILVGGGLGFLVNMAGSVVVVVITASAVSLIGCCFVALFVRYVD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UMX9-1", "uniprot_id": "S45A2_HUMAN", "id": "Q9UMX9-1", "name": "Membrane-associated transporter protein", "aln": "MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSR-----------------LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNG-------------------------ATVVAALIANPRRK------LVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAPLTEVAKGIPP-----------------------QQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQG-AKNKNHAEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGLCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLTCMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VSV1-1", "uniprot_id": "Q9VSV1_DROME", "id": "Q9VSV1-1", "name": "", "aln": "MVGVTADASQANQLSSVRNPMIKYMLKTRENHAREQDRDYSHVFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTTFREIPLPLIEQDELLRPLSEQAIKKELKKKNNTIYYIQETTQLELQMASDDPKRLEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPVSLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGE-IVPLKQARGLGTDVAIISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYASTFLSFL-AAIAAMFVLYV-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . .. :. * . : : .:. .* :. * :. **.**.*:::*:*:**.:*: . *:.* ***::**::.*::** **:*: ******* * *.. :: *: * * *:**::. . :*: :*::*:**:** ** : * ::**:*:* ::: *.: .***:****::** :*.:** .:* ::* :: .:* : :::: :*: : :: * ** . : :::.. . ::: :. .. * :: : : .:::*: *:::. ** * *.:::*: * ..:: *:****:*: *::*** .* ** * ** **..****:.* :. .*:** . ::.::* *.:*: * : :*:* .:**:*. :..**:.: *:: .*::**** *::.** :: . : * : ** * * * ::.** :**::*. .:* **. .:. .*: ::: :::: ..:.*:** ** ", "identical_positions": 151, "similar_positions": 203, "identity": "25.08%" }, { "cls_id": "homologset.agr.HGNC:16473", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q715S9-1", "uniprot_id": "NDK8_RAT", "id": "Q715S9-1", "name": "Protein NME8", "aln": "MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQALFRKLKNELNEDELLHFVVAEADSIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVIALIDEEKKIAAGEMARPQYVEIPLVD-------SLDEEYGEVHYESNVEVYNMAVINPDAVLMRKNLEIKEKITKEGFIIEIQENMLLPEEVAREFYNHMIDEPDFEEFVYSMTNRLSCVLIISQGEDTEVIEEEALPQSDDE--EEPDPLEEPHVRFAPMLVKKKRDSLQEYMDRQHMSDYCHVEDDAVKVSKFIDILFPDF------KTMKSTNVQRTLGLLYPEVCEEEKDNVLDIIQNEGFTILMQRQVVLSEEEARAVCHVHEDEDYFDNLIGYMCSNNSYILVLMREHSVERWKELIGPKTVEEAYASHPDSLCVRFASGNFPVNQFYGSSSKAAAETEIEHFFPPQSTLALIKPHVSHKERMEILKAIRDARFELTQMKEMHLTPEHASKVYFKITGKDFYKNVLDVLSSGMSVVMILTKWNAVGEWRRMMGPVDPEEAKLLSPNSLRARYGIDVLRNAVHGASNMSEAATAISNVF-----------------------------------------TESNFEN---------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q715T0-1", "uniprot_id": "NDK8_MOUSE", "id": "Q715T0-1", "name": "Protein NME8", "aln": "MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQSLFRKLKNELNEDEILHFVVAEADNIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVITLIDEERKIVAGEMDRPQYVEIPLVD-------AIDEEYGEVQYESAAEVYNMAIIKPDAVLMRKNIEVREKIAKEGFVIEIQENLILPEEVVREFYTHIADQPDFEEFVVSMTNGLSCVLIVSQ-EDSEVIQEETLPQTDTE--EEPGVLEEPHVRFAPVMIKKKRDSLQEYMDRQHMSDYCDVEDDAVKVSKLIDILFPDF------KTMKSTNVQTTLALLHPDICEEEKDDVLNVIHNEGFTILMQRQIVLSEEEARTVCKIHENEEYFDNLIGHMTSNHSYVLALRRENGVEYWKTLIGPKTIEEAYASHPQSLCVQFASGNFPTNQFYGSSSKAAAEKEIAHFFPPQSTLALIKPHVTHKERMEILKTIKEAGFELTLMKEMHLTPEHANKIYFKITGKDFYKNVLEVLSLGMSLVMVLTKWNAVAEWRRMVGPVDPEEAKLLSPESLRAKYGLDILRNAVHGASNFSEASEIISNVF-----------------------------------------TEGNPEN---------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N427-1", "uniprot_id": "NDK8_HUMAN", "id": "Q8N427-1", "name": "Protein NME8", "aln": "MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVD-------SDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDF------KKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLF-----------------------------------------EDPE-EN---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q4G2-1", "uniprot_id": "A0A8M9Q4G2_DANRE", "id": "A0A8M9Q4G2-1", "name": "", "aln": "MAAKKKEISLQININNDEQWSEALALKGLLVVDVYQQWCGPCRAVVGLFRKIKNELG-DELLHFATAEADGIEALEMYRGKCEPTFLFYAGGELVSVLRGPNAPLLQKTIQEELSNEKNVLEHGGARRAVKDEGLTEEEEVNDDTEDHPHDEDVTVPTDKSYTVAIIKPDVVAHGKADEIIMKIQDAGFVILAHEERTLTEAEAQDFYQHKAAEPYFQELVQFMSSGPSHVLVISKTEGCEDVIPAWREFIGPADVEEAR--------------REQPESLRAQYGSESLLNGLHGSSDRERASRELAFFFPNFSFSVWDSRPEEEPVERTLALVRPDAARENREEILSRIRQAGFRVAMQKELMLTEEQVRLFYSTHVEEEYFNSLMENMTSGLVLALALVKEGAVEHWRNILGPKDPIKAKNEQPDSLRAQFSVENSSINQLHGSSSSEEAEKEISFFFPPEDTLAVIKPDTQHK--EEILEEIQAQGFTISQLKDTILSREMAEEFYKEHREKPFFSQLVDYMCRGPCTMLVLTKENAVQEWRAAMGPTDPDQARLTAPESLRARFAKDVLENAVHGSSNTEHADQKIKFIFGDIGEIIPDTASPPLETEESFAELKNLQSSRSPSFGDLRNETEPDTTDGAEEMNLEMTESHAASTDQTEALETPESSQPDTGESPSL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:**:*:.** :*.:. *.* * *** *:**** *****:*: ****:****. **:***..****.* :*: :*.****.*** .*::: ::*.****:::.: :.:*::: * : *.: : .. * . : *.:*:*:**.* * *: ** . **:* ..: *.* . :** : : *:*:* *:. * :*::*: . : . *.. ::: :**: : : : . ..* ..:: : :**:* . :. :: **.*: *: .*.::::* *:: .* : *::::*:*::.: . : :*:**:.*: * *. *.* :: .:: *: ::**: :* *:** .:*: . . **::**.* ** ** .*** :.**.:***.. : :**: :: * :: :*. *: * .:.* : * *:.:::: :. * . :::*** *** *** :**.**::*:* :*:*:**::. . *.* ***:** .* :. :* : : : ", "identical_positions": 175, "similar_positions": 205, "identity": "25.66%" }, { "cls_id": "homologset.agr.HGNC:16475", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VJG8-1", "uniprot_id": "Q9VJG8_DROME", "id": "Q9VJG8-1", "name": "", "aln": "----------------MFCALSAFLTFVGVYALSSYLYEQLRTPYKLIKIRYFSGTRP----TLKERFGDWAAVTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGSQVYEHIEKETANIPISILVNNVG--IATPKSLLKYNQEETQNIIDTNVVAVSQLSRIFFQRMKAS--------KLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGGLLIPSASAYAKSAVNQLRD------EVDETPGYLWHHVQNAVATAFT---WRVRTYVACKLFNKISDNI-----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8INZ8-1", "uniprot_id": "Q8INZ8_DROME", "id": "Q8INZ8-1", "name": "Hydroxysteroid dehydrogenase-like protein 1", "aln": "---------------------MGLIYIVGSLSIAAFLYENLKSLFSIIKSVVEPFFRPNLPKTLAEKFGNWAVVTGATDGIGKEYARELARQGLNLVLVSRKEEKLIAVTNEIG-SQYNVKIKWIVADFAKGREVYAHIEKELNGIEVGILVNNVGT-IHDPESLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMIS---------RRKGAIVNLGSSSELQPHPNLTAYAATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKVRQGGLLFPNAYSYARSAVFTLG-------KTSETNGFWVHGLQYALMKLFP---MEIRTYFVYQLFKRMRIEAMEHRLKNQKLS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8BTX9-1", "uniprot_id": "HSDL1_MOUSE", "id": "Q8BTX9-1", "name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "aln": "MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLVRLHFIPRLGSR--PDLIKQYGRWAVISGATDGIGKAYAEELASHGLNVILISQEEEKLQAAAKHIA-DTYRVETLVLVADFSRGREIYAPIREALRDRDIGILVNDVGAFYPYPQYFSQVPEDTLWDIVNVNIAAASLMVHIVLPGMVE---------RKKGAIVTVSSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVTSSGAAPASFLHRCPWLAPSPRVYAQHAVSTLG-------ISKRTTGYWSHSIQFLFAQYMP---EWLWVWGANLLNRSLRKEALSCQA------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4V8B7-1", "uniprot_id": "HSDL1_RAT", "id": "Q4V8B7-1", "name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "aln": "MAAVDSFYLLYREIARSCSCYVEALALVGAWYTARKSIPVICDFYSLVRLHFIPRLGSR--PDLIKQYGRWAVISGATDGIGKAYAEELASHGLNIILISQEEEKLQAVAKHIA-DTYRVETLVLVADFSRGREIYAPIREALRDRDIGILVNDVGAFYPYPQYFSQVPEDTIWDIVNVNIAAASLMVHIVLPGMVE---------RKKGAIVTVSSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVTSSVTAPGSFLRRCPWLAPSPRVYAQHAVSTLG-------ISKRTTGYWSHSIQFLFAQYMP---EWLWVWGANLLNRSLRKEALSSQA------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3SXM5-1", "uniprot_id": "HSDL1_HUMAN", "id": "Q3SXM5-1", "name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "aln": "MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSR--ADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIA-DTYKVETDIIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVE---------RKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLG-------ISKRTTGYWSHSIQFLFAQYMP---EWLWVWGANILNRSLRKEALSCTA------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A5WWC6-1", "uniprot_id": "HSDL1_DANRE", "id": "A5WWC6-1", "name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "aln": "MAAVDSFQLLYREIARSCSGYVETLALVGACYMASKTVIFMRDCYSLIRLYFVPRLVRH--RDLSQQYGQWAIICGASEAIAKAYAEELARHGICVILISKDLSSVSDTARLIS-NNYGVEAICIEADFNQGPSACKPIKDAISSKDIGFLVNSFDGTLEISQNFLELSESVLWGTINRNIAATTLVTRLALPAMME---------KGRGAVVNISSGHCFHPIPRKAAFSASTAFLDNFSRSLHYEYGDQGVFVQSLLPFRVAS--QRPEGSAPPASWLVPSPQVYASHALSTLG-------ISHRTTGYWPHSMQLGLVKMMP---EWVWMLGSRVFTMAT---------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38286-1", "uniprot_id": "MKAR_YEAST", "id": "P38286-1", "name": "Very-long-chain 3-oxoacyl-CoA reductase", "aln": "----MTFMQQLQEAGERFRCINGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFD---KYGAKTGKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELSKDAIDVELIISYLVTSSMSKIR----RSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPYWAHAVYQFVITETFGVYSKIVNSINYSFHKSIRIRALKKAARQVKKE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .* : :. . : * :. : **::.*.* :*.::* :.: ::*::: ..: . : * . *.. : .***... . : : :. . : * :. : : : :* ::.:.* * * : ::.:. : : .* * : *: : . *.: : *.. :. :: : : * : . : : ", "identical_positions": 25, "similar_positions": 85, "identity": "6.98%" }, { "cls_id": "homologset.agr.HGNC:16476", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2RUW1-1", "uniprot_id": "TOLIP_RAT", "id": "A2RUW1-1", "name": "Toll-interacting protein", "aln": "-------------------MATTVSTQRGPVYIGELP-QDFLRITPTQQQQQIQLDAQAAQQLQYG--------GAVGTVGRLSITVVQAKLAKNYG----MTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEI----------------------FDERAFSMDDRIAWTHITIPESLKQ---------------------GQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQG--------------VGYVPIAGMPAVCSPGMVPMAMPPPA-VAPQPR--------CNEEDLKAIQDMFPNMDREVIRS------VLEAQRGNKD-------------AAINSLLQMGEES--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZ06-1", "uniprot_id": "TOLIP_MOUSE", "id": "Q9QZ06-1", "name": "Toll-interacting protein", "aln": "-------------------MATTVSTQRGPVYIGELP-QDFLRITPTQQQQQIQLDAQAAQQLQYG--------GTVGTVGRLSITVVQAKLAKNYG----MTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEI----------------------FDERAFSMDDRIAWTHITIPESLKQ---------------------GQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQG--------------VGYVPIAGMPAVCSPGMVPMAMPPPA-VAPQPR--------CNEEDLKAIQDMFPNMDREVIRS------VLEAQRGNKD-------------AAINSLLQMGEES--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H0E2-1", "uniprot_id": "TOLIP_HUMAN", "id": "Q9H0E2-1", "name": "Toll-interacting protein", "aln": "-------------------MATTVSTQRGPVYIGELP-QDFLRITPTQQQRQVQLDAQAAQQLQYG--------GAVGTVGRLNITVVQAKLAKNYG----MTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEI----------------------FDERAFSMDDRIAWTHITIPESLRQ---------------------GKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQG--------------VGYVPITGMPAVCSPGMVPVALPPAA-VNAQPR--------CSEEDLKAIQDMFPNMDQEVIRS------VLEAQRGNKD-------------AAINSLLQMGEEP--------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZV43-1", "uniprot_id": "TOLIP_DANRE", "id": "Q7ZV43-1", "name": "Toll-interacting protein", "aln": "-------------------MATTISTQRGQVYIGELP-QDFLRIMPTQQQQQVQLDAQAARQLQYG--------GSLGTAGRLSITVVQAKLAKNYG----MTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEI----------------------FDERAFSMDDRIAWTHVTIPENLRE---------------------GTVVDEWYSLSGRQGDDKEGMINLVMSFATIPAGMMMQPQPVVLMPTVYQQG--------------VGYVPIAGVPGMYNQGVVPMGMPAAAPVASQSAP-------CSEEDLKALQDMFPNLDKEVIRT------VLEAQQGNKD-------------AAINSLLQMAEEL--------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q05610-1", "uniprot_id": "DON1_YEAST", "id": "Q05610-1", "name": "Donuts protein 1", "aln": "MGKKNRKGKENNAAKT---SFLKVENIKNTNSGLELPSQDYTNVEEKESSPKTDFPLITKEHVNTK--------TDSNILDYPTIGDLVSSVEKLCV----LKELKIAFPEVDDTLIKAILIASQGVLEPAFNSLLYYSSPEENTDFALPMKPI-------SVEDYSKINVSEILQREIFDDIEDEFSGQGINGSMVI---------------------SKIESELSSLAEHIGNISTPGSNREVAESTRNVAVAEGHNTILSNEDSILKGKEKGKEEEKEKGEEKGVNSLKGAAVKVVAKSLKNNRIPVTVKRNEPSNNLFDVLNCDESEEEEEQDVETNTSNQERKNQGGNTEVPEAQRDSADRLPAKDDGGYKSAFGTDSCGLFAADAKDEKKQVHPSRQELSFT---", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q08412-1", "uniprot_id": "CUE5_YEAST", "id": "Q08412-1", "name": "Ubiquitin-binding protein CUE5", "aln": "MEEKEGIKDSSLLEKSNVPESINEDISKTTDVDLNSDGKKDNDTSAKDGTPKVEEKVNKSSGIDEDEVVTPAEDAKEEEEEHPPLPARRKSEEEPSKENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDPESGKDIELPTQPVRKNPEAPARRRQTQLEQDELLARQLDEQFNSSHSRRRNRDRATRSMHEQRRRRHNPNEREQHHEDSEEEDSWSQFVEKDLPELTDRAGRSLQDTANKVSNWISDAYRRNFASGNEQNDNQHGHQDQQEWEPEIVDLSQGGKNSRPQQPERRRFNSFGVQVGDDSLESHGITLHNEDGFEDDEDVPPQLPTRTKSGESTGKVVAETTYIDTPDTETKKKWQPLPPEPLDTTPTKVNAVSRNKKNPDEDEFLINSDDEM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : : :. .: : : :: : . : : .:. : * :*. .* :* :: : * .: * : * : : . : . .. .: : . : : .. :. * . : .*. : :*: .: . * *: . :: ", "identical_positions": 12, "similar_positions": 61, "identity": "2.92%" }, { "cls_id": "homologset.agr.HGNC:16484", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VIH3-1", "uniprot_id": "S28A3_RAT", "id": "Q8VIH3-1", "name": "Solute carrier family 28 member 3", "aln": "MSRSDPDPGKNSEPSKSKMSLELR-PTAPSDQGRLNEAFQDED--LEEQNAPGNSTVRSRVVQSGEQGRAKQDDRQITIEQEPLGPKEGTEEESEDERQKGFLERKYDTVCEFCRKHRVILQHTIWAVLLTGFLALVIAACALNFHRALPLFVITLVTIFFVVWDRLMAKYEQRIDDVLSPGKRLLERHWFWLKWVVWCSLILAVILWLALDTARLGQQQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYT-DHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKSELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDSRNLLEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDRFMVAKLIGYKTFFNEFVAYEHLSKFINLRKAAGPKFVNGVQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGMLSDTPVAINCHHVLE---SSKVLSNTTEVASCCQGLFNSTVARGPNDVLPGGNFSLYTLKSCCNLLKPPTLNCGWIPNIP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ERH8-1", "uniprot_id": "S28A3_MOUSE", "id": "Q9ERH8-1", "name": "Solute carrier family 28 member 3", "aln": "MSRADP--GKNSEPSESKMSLELR-PTAPSDLGRSNEAFQDED--LERQNTPGNSTVRNRVVQSGEQGHAKQDDRQITIEQEPLGNKEDPEDDSEDEHQKGFLERKYDTICEFCRKHRVVLRSTIWAVLLTGFLALVIAACAINFHRALPLFVITLVTIFFVIWDHLMAKYEQRIDDFLSPGRRLLDRHWFWLKWVVWSSLILAIILWLSLDTAKLGQQNLVSFGGLIMYLILLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGRQVQTFLGYTDTGARFVFGEKYT-DHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFIGQTESPLLVQPYLPHVTKSELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKSAMKMENGDSRNLLEAASQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFNYPELSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYDHLSKLINLRKAAGPKFVNGVQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGILSDTPVDINCHHVLE---NGRVLSNTTEVVSCCQNLFNSTVAKGPNDVVPGGNFSLYALKSCCNLLKPPTLNCNWIPNKL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HAS3-1", "uniprot_id": "S28A3_HUMAN", "id": "Q9HAS3-1", "name": "Solute carrier family 28 member 3", "aln": "--------------------MELRSTAAPRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYK-DHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIPGGNHSLYSLKGCCTLLNPSTFNCNGISNTF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z7N3-1", "uniprot_id": "A1Z7N3_DROME", "id": "A1Z7N3-1", "name": "", "aln": "----------------MAEPIEGEQEEKPPPSRAKRITYLVLHVLLHIIFISYFTAATIIFIFYDKDSKECWPNRGSEATTESIDNSTEDDDDDDYDTEETSEKPVPEVKPKLLCQINWCHGYGFLIVLFILFYILWLYYWVFKPFVGIKLYNN---------------YLEPVIDKWIAFSR-------QWIVSGVMLAIVLAVVVAYLGFECRNDAYKAIGLLGPVCFVLIGFAVSKHHLQVPWRIVTHGLLGQLLLGILCLRLPFGRSIFQCLGDKVTIFLNYAQHGARFVYGDRICDEYVFAFAILAVVFFFSVITSIMYYLGWMQFILNGFGFLLQAMVGTTVCESVNAAGNVFLSMTESPLVIRPYIEILTVSELHAICTSGYATVAGTVLGAYVSFGASASFLIAASVMAAPGSLAFAKLFYPETEES-LTRSDNIKLESSTDTSILDAAASGAAAALLIVLGIVSNIIAFLAIVFFLDAVTEWIFELIGLHNITLLYILSQIFIPIVFVMGVPWHDCQAIGLVVAQKSFINEFVAYRNLGILVSDKK-------------VDPRSAAIATFALCGFANPGSLGIVIASLSAMAPSRRSDITRVAFRSYFAGSFVSFTSASLAGILIQN-------------------------------------------EYTGGN---------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* . * . : . *. . .: : :. . :. :. :::.: :: : :. : : . : :*: : : : .:: . .: *: * **. :: .: *: : :::**::. .: . : :.: * : :::: * .**: :* ** * *: *:***:* ** * *: :* :* ** *:: ** **:*:: ::.*** :*.:*.***.: *::**** **:*:. .*::: . *:: *** *:**:*:. *****:::**: :* ****:* *:*::*:**:*****:***..::.*::****:**.:** ****:****:. :* .. :*:*.. . .:*:**:.**:::: :* .*. *:*****:: *:::. .*: .::. :::: * * **:*: *:*** *:* :. ::. *:*:****** :*. : :* :. ** ***:******* *******..*:::****: **: *.*: :**:...* :*.:**:* .. .*** ", "identical_positions": 184, "similar_positions": 208, "identity": "25.84%" }, { "cls_id": "homologset.agr.HGNC:16485", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8NHY5-1", "uniprot_id": "HUS1B_HUMAN", "id": "Q8NHY5-1", "name": "Checkpoint protein HUS1B", "aln": "MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGS-GGLHEARLWC-EVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAG--ASSLKLQLTHKRRPSLTVAVELVSSLG-RARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFLEGQQIHPTTALCNIWDNTLLQLVL-VQEDVSLQYFIPAL--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8K572-1", "uniprot_id": "HUS1B_MOUSE", "id": "Q8K572-1", "name": "Checkpoint protein HUS1B", "aln": "MRFRARITSKRFIELFIQVSSTVAKLAKVCVLRVCPDRLYFCPMG---LLGEAQLWG-EMRRDVFHHFCMEGASQEFNEICLELMSEHLARAVKNAGN--ASSLKLQLTNKQRPCLTLVVELASCPG-HTRAVVHDLPVRVLPRRRWKDCTEPHVRGSDVSVYLPALKTLKNMVERMANVGSHVLVEANLNGRMNLTVETDRVTIKSYFKNLGNPPNAVLCMSQGRDPETMVQVRVDNRKLLQCFDGHQINPTMALCNILSNTLLHLVL-VHEDISLQYFIPAS--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VN60-1", "uniprot_id": "HUS1_DROME", "id": "Q9VN60-1", "name": "Checkpoint protein Hus1-like", "aln": "MKFRALMQDPLYMKEFQAIVATLTKLAKDCVMILGSRQMHFIVNEDQSSAASPLVWAGITAEEYFPEYRMEAAHPDQEYIVLGVSSANLGRALSVLRGGGVNSCKLKLQRIQFPCISVIASVLTSSSTEAREVVHDVPVTIIPGSDWSAYVVPRVPNSQLALGLPSLRLLKSLIDKLKNISPSLEFQVNVDGELNVIATSEMSTVTSRFQKL--------LIRTVSGSQQEASCSVDSRKASAFFGALQLPNEELTIGIDREHSIHLQIDVRQDVVLHSILPAVCM", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:*** : . :: * : .*:::*** **: : . : * .. :* . * .: **.. : : * * : : :*.** . ..* **:* . : *.::: ..: :. . .:* ****:** ::* * * : *: :: ** : *:.::::: *:.. : .:.*:.*.:.: :: :: * *::* : . : .. **.** : . *: .* : ::* : *::*: *: ::** ", "identical_positions": 58, "similar_positions": 100, "identity": "20.28%" }, { "cls_id": "homologset.agr.HGNC:16486", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9PY16-1", "uniprot_id": "E9PY16_MOUSE", "id": "E9PY16-1", "name": "", "aln": "MAGE------------------RRRALL----ELLTRPGNTRCAD----------------------------CGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWDEAQVEFMASHGNEAARATFESKVPPFYYRPTFSDCQLLREQWIRAKYERQEFVHVEKQEPYSTGYREGLLWKRGRDNGQFLSRKFVLTEREGALKYFNKNDAKEPKAVMKIEHLNATFQPAKMGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLEGLPLSTQGHHWPHGITIVTPDRKFLFTCETESDQREWIAAFQKVVDRPMLPQEYAVEAHFKHKP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75689-1", "uniprot_id": "ADAP1_HUMAN", "id": "O75689-1", "name": "Arf-GAP with dual PH domain-containing protein 1", "aln": "MAKE------------------RRRAVL----ELLQRPGNARCAD----------------------------CGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I5ZRW6-1", "uniprot_id": "A0A8I5ZRW6_RAT", "id": "A0A8I5ZRW6-1", "name": "", "aln": "MPPQGPWCPWEETLTKLQWEAGQDEVVLSWSPEALQGPAMVQWGGGSLVLHGSHLPLSDLPFNMFGKAGYARVSGVPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWDETQVEFMTSHGNEAARATFESKVPPFYYRPTFSDCQLLREQWIRAKYERQEFLHVEKQEPYSTGYREGLLWKRGRDNGQFLSRKFVLTEREGALKYFNKNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLEGLPPSTQSHHWPHGITIVTPDRKFLFTCETESDQREWIAAFQKVVDRPMLPQEYAVEAHFKHKP", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. : : ..:* * * *. .: .. .*.***************************************:*:*****:****:**** ******.****** ********************:: *******:*****:*****************************:***********************:***************************************************.********************************************************************.*:* ***.******************:**********:*****.********************", "identical_positions": 332, "similar_positions": 31, "identity": "78.3%" }, { "cls_id": "homologset.agr.HGNC:16487", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R2V5-1", "uniprot_id": "ADAP2_MOUSE", "id": "Q8R2V5-1", "name": "Arf-GAP with dual PH domain-containing protein 2", "aln": "MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGIFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHHGNLNVKAKFEARVPAFYYVPQANDCLVLKEQWIRAKYERQEFTAIDKAVSHPGNREGFLWKRGRDNAQFLRRRFVLLSREGLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGHPHGLQITYRKEGHTRNLFVYHDSGKEIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFELGQVFLGSNEQGYEVWEDLPKGIRGNRWKAGLTVITPERKFIFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAETGCGLG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JK15-1", "uniprot_id": "ADAP2_RAT", "id": "Q9JK15-1", "name": "Arf-GAP with dual PH domain-containing protein 2", "aln": "MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGVFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHNGNLSVKAKFEARVPTFYYVPQASDCLVLKEQWIRAKYERQEFMA-EKAVSPPGDREGFLWKRGRDNSQFLRRRFVLLSREGLLKYYTKEEGKTPKAIINIKDLNATFQTEKIGHPHGLQITYRKEGQTRNLFVYHDSGKEIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGYEVWEGLPQGIRGNRWKVGLTVITPERKFVFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAKSG----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NPF8-1", "uniprot_id": "ADAP2_HUMAN", "id": "Q9NPF8-1", "name": "Arf-GAP with dual PH domain-containing protein 2", "aln": "MGDRERNKKRLLELLRAPDTGNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREFMADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGLQITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEAYEDLPKGIRGNRWKAGLTIVTPERRFVLTCPSEKEQQEWLESLRGVLSSPLTPLNRLTASTESGRSSR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***************:*..***.******************:****:*.**********:************:**** *:*** **********:***:***.****************:** * :::* **:************:*****:****:*******:***:**:***:*.************************::*:********:*********************:***:********::****************::*********** :*************** ******.:*****.:*.**:********.***::****:*::***:****:**************:**: **:*:::* ", "identical_positions": 311, "similar_positions": 57, "identity": "81.63%" }, { "cls_id": "homologset.agr.HGNC:16488", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K351-1", "uniprot_id": "A0A0G2K351_RAT", "id": "A0A0G2K351-1", "name": "", "aln": "MSGSNPKATTAGSQAGPGGLVAGKEEKKKAGGGVLNRLKARRQGPPHTSDDGPGTAVTEQELLALD-TIRPEHVLRLNRVTENYLCKPEDNVYSIDFTRFKIRDLETGTVLFEIAKPCISDQDQ------------DTEEESVDVDISVGRFVRYQFTPAFLRLRTVGATVEFTVGDRPVTGFRMIERHYFRERLLKTFDFDFGFCIPSSRNT--------------FRLMIENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C4B4-1", "uniprot_id": "U119B_MOUSE", "id": "Q8C4B4-1", "name": "Protein unc-119 homolog B", "aln": "MSGSNPKAATAGSQAGPGGLVAGKEEKKKAGGGVLNRLKARRQGPPHTPDDGSGAAVTEQELLALD-TIRPEHVLRLNRVTENYLCKPEDNVYSIDFTRFKIRDLETGTVLFEIAKPCISDQDQ------------DAEEESVDVDISVGRFVRYQFTPAFLRLRTVGATVEFTVGDRPVTGFRMIERHYFRERLLKTFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLVMHNKADYAYNGGQ--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A6NIH7-1", "uniprot_id": "U119B_HUMAN", "id": "A6NIH7-1", "name": "Protein unc-119 homolog B", "aln": "MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQAPHHAADDGVGAAVTEQELLALD-TIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIRDLETGTVLFEIAKPCVSDQEE------------DEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFREHLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q90Z08-1", "uniprot_id": "U119B_DANRE", "id": "Q90Z08-1", "name": "Protein unc-119 homolog B", "aln": "MNSQSSRNETAATAVN-GSDSAAASRDHKSGGGVLKRLKSRRNQVDRRP-------VTEEELRALGRDITPDEVLGLRAVARDYLCKLEDNIYNIDFTRFKIRDLETGTVLFEIAKPPHCDLDE------------EDDENR-DADTSAGRFVRYQFTPAFLKLRTVGATVEFTVGDQPVTNFRMIERHYFQDRLLKSFDFDFGFCIPNSRNTCEHIYEFPQLPEDLIRLMIEHPYETRSDSFYFVDNKLIMHNKADYAYNGGQ--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9XYQ2-1", "uniprot_id": "UN119_DROME", "id": "Q9XYQ2-1", "name": "Protein unc-119 homolog", "aln": "MSVVG-KQLNPVQSSGAGAVTTSSSAAAGSSSSNSGVEANGGSGGSSGAAAAGAGASGDAKRPAESSSVTPDEVLHLTKITDDYLCSANANVFEIDFTRFKIRDLESGAVLFEIAKPPSEQYPEGLSSDETMLAAAEKLSLDDTADPNAGRYVRYQFTPAFLNLKTVGATVEFTVGSQPLNNFRMIERHFFRDRLLKTFDFEFGFCFPFSKNTVEHIYEFPNLPPDLVAEMISSPFETRSDSFYFVGNRLVMHNKADYAYDGGNIV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. . : . . *. :. . :... . . : : * . : *:.** * :: :***. : *::.************:*:******** : : : . .* ..**:**********.*:***********.:*:..*******:*:::***.***:****:* *:** . **. *:**********.*:*:*********:**: ", "identical_positions": 106, "similar_positions": 62, "identity": "39.85%" }, { "cls_id": "homologset.agr.HGNC:16489", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C9S8-1", "uniprot_id": "ATG4A_MOUSE", "id": "Q8C9S8-1", "name": "Cysteine protease ATG4A", "aln": "----------------MESVMSKYENQILIFPDYL---------EEFPDTDELVWILGKQHPLKTE--------------------KSKLLSDISARLWFTYRRKFSPIGGTG-----------------------------PSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGE-GKSIGEWFGPNTVAQVIKKLAL-FDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAG----DFLTASNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTF---HCLQSPQRMSI--------------LNLDPSVALGFFCKEEKDFDNWCSLVQKEILKEN-LRMFELVQKHPS--------HWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG--------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JFS9-1", "uniprot_id": "A0A0G2JFS9_MOUSE", "id": "A0A0G2JFS9-1", "name": "Cysteine protease", "aln": "----------------MESVMSKYENQILIFPDYL---------EEFPDTDELVWILGKQHPFKTE--------------------KSKLLSDISARLWFTYRRKFSPIGGTG-----------------------------PSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGE-GKSIGEWFGPNTVAQVIKKLTL-FDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAG----DFLTVSNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTF---HCLQSPQRMSI--------------LNLDPSVALGFFCKEEKDFDNWCSLVQKEILKEN-LRMFELVQKHPS--------HWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG--------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6A6C4-1", "uniprot_id": "A0A8I6A6C4_RAT", "id": "A0A8I6A6C4-1", "name": "Cysteine protease", "aln": "-----MTAGEWSQGVERSTVMSKYENQIIIFTEYL---------EEFPDTDELVWILGKPHLLKTE--------------------KSKLLSDISARLWFTYRRKFSPIGGTG-----------------------------PSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGE-GKSIGEWFGPNTVAQVIKKLAL-FDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADTAGESPPDSLIASSQSKGTSAPCLAWKPLLLIVPLRLGINQINPVYIEAFKECFKMPQSLGALGGKPNNAYYFIGSLGDELIFLDPHTTQTFVDTEESGLVDDHTF---HCLQSPQRMSI--------------LNLDPSVALGFFCKEEKDFDNWCSLVQKEILKEN-LRMFELVQKHPS--------HWPPFVPPAKPEVTTTGAEFIDSTEQLEDFDLEEDFEILSV---------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WYN0-1", "uniprot_id": "ATG4A_HUMAN", "id": "Q8WYN0-1", "name": "Cysteine protease ATG4A", "aln": "----------------MESVLSKYEDQITIFTDYL---------EEYPDTDELVWILGKQHLLKTE--------------------KSKLLSDISARLWFTYRRKFSPIGGTG-----------------------------PSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGE-GKSIGEWFGPNTVAQVLKKLAL-FDEWNSLAVYVSMDNTVVIEDIKKMCRVLPL-SADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTF---HCLQSPQRMNI--------------LNLDPSVALGFFCKEEKDFDNWCSLVQKEILKEN-LRMFELVQKHPS--------HWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV---------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VPW2-1", "uniprot_id": "Q9VPW2_DROME", "id": "Q9VPW2-1", "name": "Cysteine protease", "aln": "----MLVGLSDQLARIMESVFEAYLGPDSVLASAVGQAVGSGEPEDIPRRNTDVWVLGKKYNAIQE--------------------LELIRRDIQSRLWCTYRHGFSPLGEVQ-----------------------------LTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFWTPDCRDAT-YLKIVNRFEDVRNSFYSIHQIAQMGESQ-NKAVGEWLGPNTVAQILKKLVR-FDDWSSLAIHVAMDSTVVLDDVYASCR--------EGG---------------------SWKPLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYLDPHTTQRTGAVAQKTAAAEQDYDETYHQKHAARLNF--------------SAMDPSLAVCFLCKTSDSFESLLTKLKEEVLSLCSPALFEISQTRAVDWDTTEDIDWPTMPDIDWPAGTSDSDSFAIVEESGRDSDAGCSGAIGSGKKPSERAVI------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53867-1", "uniprot_id": "ATG4_YEAST", "id": "P53867-1", "name": "Cysteine protease ATG4", "aln": "MQRWLQLWKMDLVQKVSHGVFEGSSEEPAALMNHDYIVLG----EVYPERDEESGAEQCEQDCRYRGEAVSDGFLSSLFGREISSYTKEFLLDVQSRVNFTYRTRFVPIARAPDGPSPLSLNLLVRTNPISTIEDYIANPDCFNTDIGWGCMIRTGQSLLGNALQILHLGRDFRVNGN-ESLERESKFVNWFNDTPEAPFSLHNFVSAGTELSDKRPGEWFGPAATARSIQSLIYGFPECGIDDCIVSVSSGDIYENEVEKVFAE-----------------------------NPNSRILFLLGVKLGINAVNESYRESICGILSSTQSVGIAGGRPSSSLYFFGYQGNEFLHFDPHIPQPAVEDSFVESCHTSKFGKLQLSEMDPSMLIGILIKGEKDWQQWKLEVAESAIINVLAKRMDDFDVSCSMDDVESVSSNSMKKDASNNENLGVLEGDYVDIGAIFPHTTNTEDVDEYDCFQDIHCKKQKIVVMGNTHTVNANLTDYEVEGVLVEKETVGIHSPIDEKC", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:. : . * * : . . : *:.:*: *** * *:. . .:* *****:* ** :*.:** *****: : .. :::: * * :. :*:*::.. * .* ***:** :.*: ::.* * : . *::.. : :: . . :*::: ::***. :* * :: :. .* * **:*..: **:* .:*.:.:*** .* : : : : : * : .:.* ..*: : . * :. : . . : . . * . .. . . ", "identical_positions": 66, "similar_positions": 108, "identity": "12.5%" }, { "cls_id": "homologset.agr.HGNC:16490", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A305-1", "uniprot_id": "A0A8I6A305_RAT", "id": "A0A8I6A305-1", "name": "dipeptidyl-peptidase IV", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MKIPSGRCNMAAAMETEQLGVEIF--------------------------ETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVKRADPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLS---------------------------------------WKPLLDL-FQATLDYG------MYSREEELLRERKRIGTVGIAAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNLVTREERRLTYVHNELASMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAEGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTHLQIVLISPELFIP-------VEDDAMDRQRLIESVPDSVTPL-IIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITS--ILKESKYKRSSGGLPAP------SDFKCPIKEEIAITSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGDVVRLTDRGYSHSCCLSRHCDFFISKYSN-QKSPHCVSLYKLSSPDDDPVHKTKEFWATILDSAG-PLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80YA7-1", "uniprot_id": "DPP8_MOUSE", "id": "Q80YA7-1", "name": "Dipeptidyl peptidase 8", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MKIPSGRCNMAAAMETEQLGVEIF--------------------------ETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLS---------------------------------------WKPLLDL-FQATLDYG------MYSREEELLRERKRIGTVGIAAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAAGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKHAWSILLDRSQTHLQIVLISPELFIP-------VEDDAMDRQRLIESVPDSVTPL-IIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITS--ILKESKYKRSSGGLPAP------SDFKCPIKEEITITSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSRHCDFFISKYSN-QKNPHCVSLYKLSSPEDDPVHKTKEFWATILDSAG-PLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6V1X1-1", "uniprot_id": "DPP8_HUMAN", "id": "Q6V1X1-1", "name": "Dipeptidyl peptidase 8", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------MWKRSEQMKIKSGKCNMAAAMETEQLGVEIF--------------------------ETADCEEN-IESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLS---------------------------------------WKPLLDL-FQATLDYG------MYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIP-------VEDDVMERQRLIESVPDSVTPL-IIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITS--ILKESKYKRSSGGLPAP------SDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSN-QKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAG-PLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VC19-1", "uniprot_id": "Q9VC19_DROME", "id": "Q9VC19-1", "name": "Dipeptidyl peptidase 9", "aln": "MESRTQMNQSNQQQQQQRNRLPSSPSPPLSVVSLTGGPNANTTLMGLEHDAVPSSQLGRNNNNGGGHHRSHSITNAATTSLANLLDGFTARVSTAVSVAGGTNMLMDRSSQSAASTPGSTHSIASLTSMGSLGTTANALYSSIGSALNSITSPIQAAAAAATATTTEVVVAAASVITNHLSSPTSGTPPHGLDVDEGDDECDDCEEDEDDPVDNDGHIAAPTPNKSWAENKQVVQEIRKKMCNLSSMVPTNVQFRHLSD----GRARCYFLGTPPQSWETTLLFADINLTQSEEQQLLVQRLEGIASDEWSPTMNAGSPTSSGHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAREYQLLQERKRLSTWGITSYELHKPSGKLVFPCFNDLYQCLDTG---YNSGLLFPTQLRTCPQWTALDPQICPQNSDMIAYISDCDLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEEFSRYQGFWWQPHSNDG-----IYRIVYEEVDESEVSVYTFPSSTAMHGRVDEYRFPRTGSPNAKSKLKLVQFVLNEALQVSEIAIKDLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFLDLT-ETSVTFLWASE-ETGFRHLYLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWEVLARN---LWVDKANKLVYFVGLRDTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKLMLLVYCNIQRLPSCKVMRVNQTCSNGGVNGIQISLVGYLHEGGKPEPQYCP-QIFSPQLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMHMLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNNEAGYSAGSVLEYVNSFPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYETKLLSFLQNL-----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 343, "similar_positions": 294, "identity": "30.33%" }, { "cls_id": "homologset.agr.HGNC:16491", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ERV7-1", "uniprot_id": "PIDD1_MOUSE", "id": "Q9ERV7-1", "name": "p53-induced death domain-containing protein 1", "aln": "-------------------------------------MAA--------VLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPA--------------GNQLNLDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRDNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWLLFVPP--RVRRCREVVVRTRSNNTWNDLETQLEEEAPKR---------LWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTTTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLPR----------LRGAQGSGQGTDFSLM-PLNLGDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQ-PGAVGHLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M0R797-1", "uniprot_id": "M0R797_RAT", "id": "M0R797-1", "name": "p53-induced death domain-containing protein 1", "aln": "-------------------------------------MAA--------VLEGPKPEETAAAAEDAARPTVEAVASRPGVPILLA--------------GNQLNLDLRPGGCRRLQYLCSQQHTQLLQVEFLRLSTHEDPRLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPASMRDLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLSENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPPGLAHLPLITRLDLRDNQLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLFLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPITIHYRLWLPEPGLVSLGPHDFLLSGVLELQPHGVAFQQNVSLWLLFVPPRVRVRRCREVVVRTRSDNIWNDLETHLEEEAPKR---------RWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTSTWDDISTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRSKVDATLSRLLDRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNMKEVYITTALDREAQDVRGQVSFYRGSLPMEVPEEAEAARRRKGTDALWMATLPIKLPR----------LRGAQGSGQGTDFSLM-PLNLGDAETGFLTQSNLLSVASRLGSDWPTVALHLGMPYRKLQRIRHEFRDDLDGQIRHMLFSWAESQTGQ-PGAVGHLVQALEQSDRQDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPSTSALQNPESAQA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9HB75-1", "uniprot_id": "PIDD1_HUMAN", "id": "Q9HB75-1", "name": "p53-induced death domain-containing protein 1", "aln": "-------------------------------------MAA--------TVEGPE-LEAAAAAGDAS----EDSDAGSRALPFLG--------------GNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPP--QARRCREVVVRTRNDNSWGDLETYLEEEAPQR---------LWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPR----------LRGSEGPRRGAGLSLA-PLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQ-PGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IWL1-1", "uniprot_id": "A0AC58IWL1_DANRE", "id": "A0AC58IWL1-1", "name": "", "aln": "MEREEKKQTERKEWPAPPDEEGDAYSFTNKRRAMLMETAAGPDFLGKLETEESPPLGVSLCSEHTDTWAPSIVSSSSSSLPCLSPPLPPSVGLDGVLVEERLVLDVYRGGAEVLPVFWEFVQERMRGLQYLRLGS-EDEGALERALRVLPR-LTQLRSLAIRGCRFHDPQGDPLPGLLSSLPDSVSSLSLLVHLDLSFNRFSSLPSCLLSFSHLSELLLCHNNLTTLPEGIGALASLRRVSLLGNRLVDLPQDLGLLCGLEELDVSFNLLEKLPDELGQLQNLQRLELSNNKLRALPETLGSLRSLRQLLIQSNDLRSVPDCLHSLPMLDKLDVRNNPLGRPPTPPLLAQLT-----PVVEDS-------------EIPELHLRFNQHSFQVSPAGCHVFLPGGAELLFPRQCVGVVTQLQWAEKRPDRKWVWLEEHDVLLSRQLELRPHGATFQKLVGVCIPYRKT-----RKGDVVVRRFDGQSWTTLTTMTRRGSDKHSCRPGGRPARLACCSVSQFSWFVAVCCPFLDSCSVSPEGALLVSQCDPGIKLSFPPNCTAETRTVTLQVLQVALSEVQDLTGDPHASAGPLLRLSQTPSMHFLQPIRVQVPLPPGVTGHMVDLSRLHLMHGDPTAHTWTDVTAQVSLYVTHIYAVFFITHFSWYWLWYTTHRCVSGVVRKMYHRLKQFRVRFLALQRKNDPEQILLQCLPSDKAESRLESLADQYEGPQPSELCVLLEGEQFFAGFERGIDINSDRPDCKDGRLSFTFYSHLKNIKEVYVCATHP-VQTTVRGQVSFYRGEVPSDLP--EEVARKRKGHDDQWMATLPLRIPINMHMIKWSTHLESFVKQKSEIDGSISGELNLGDPESGYLTQTNLLSISLRINQEWQNIGINLGMSYEQLERIRHQHRDNFGAQVLAMLFHWARGQQGTGPGAVQRLMTALVDSGRRDLAEEVEDIVTLGKRKYEESLKRVGLET-----PVTSTE--PQSS--", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * .: .: .: . : . . ::* **: **.. * : :: :::***.: ** *: :* :* * ****.::* : :.. * * * *:.** .: .*: *.******* :.:**:*: .: *. ***.** *: ***.:***.:* ::: * * ** ** *. *:.**:* ***:.:* *:* * .* .*:*:.*:*: ** :*..***** *:::** * *** * **:: :**:*:* * *. * * :. *: * * *:*.* * : .** *:* ** * *. *..* ** .. . ::: *: * * ** *** ***:***.:**: *.: : : . * :**** ..: * * * .. : :: * *.*.:****:.* *. ::* :.***:** *. .**::: ***. * *.* *::**:::* *:: * :..*:..*** ***: . ****: **:***.*:** :* *:***:: * : ** *:::** * .**:** * :************: **.*:.** :.**: .**.::****:.****:****** .*.:: * * :*.**:**: ::***:***.******:::***** :**:.*.*******:****: :: ********** :* :* *.**:*** * ******:::* *.. . *: *****.*:*:***:****:: *:. :* :.::**:.*.:::****:.**::. *: *** **. * * **** *: ** :*.*:*:****. :: **::**::*::* ** . * :*: *:.: ", "identical_positions": 374, "similar_positions": 262, "identity": "37.51%" }, { "cls_id": "homologset.agr.HGNC:16492", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80YR2-1", "uniprot_id": "FHI2B_MOUSE", "id": "Q80YR2-1", "name": "FHF complex subunit HOOK-interacting protein 2B", "aln": "--MLSRLGALLQEAVGAREPSIDLLQAFVEHWKGITHYYIESTDENTPAKKTDIPWRLKQMLDILVYEEKQQASSGEAGPCLEYLLQHKILETLCTLGKAEYPPGMRQQVFQFFSKVLSQVQHPLLHYLSVHRPVQKLLRLGGTVPGSLTEKEEVQFTSVLCSKIQQDPELLAYILEGKKIIGKKKTARESTAPPKDIAGYRDKDCPHSDALNRDPGLDKEHCGVPALSIHLPAETEGPENGPGESNLITSLLGLCKSKKSRLALKAQENILLLVSVASPAAATYLTQSTSCCMAIAEHLCQLYRSMPACLDPADIATLEGISWR---LPSAPSDETAFPGKEALAAFLGWFDYCDHLITEAHTVVADALAKAVAEKLFVETLQPQLLHVSEQSILTSTALLTALLRQLRSPALLQEAMTFLLGTDQHPAAIED-SPHTLGTHLIMHCDHLSDEISIATLRLFEELLQKPHEQAIRSLVLQNLEGRLYVARGS--------PEPESYEDTLDLEEDPYFTDGFLDSG----LQPSTKPPPAPATSSDGKTAVTEIVNSFLCLVPEEAKTSAFLEENGYDTYVHDAYGLFQECSSRVAHWGWPLGPAPLDSHEPERPFFEGRFLQVLFDRIARILDQPYSLNLQVTSVLSRLALFPHPHIHEYLLDPYISLAPGCRSLFSVLVRVIGDLMQRIQRVPQFSGKLLLVRKQLMGQVPGEHLDHQTLLQGVVVLEEFCKELAAIAFVKFPPHGPYLNFSPPPEGQV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86V87-1", "uniprot_id": "FHI2B_HUMAN", "id": "Q86V87-1", "name": "FHF complex subunit HOOK-interacting protein 2B", "aln": "--MLSRLGALLQEAVGAREPSIDLLQAFVEHWKGITHYYIESTDESTPAKKTDIPWRLKQMLDILVYEEQQQAAAGEAGPCLEYLLQHKILETLCTLGKAEYPPGMRQQVFQFFSKVLAQVQHPLLHYLSVHRPVQKLLRLGGTASGSVTEKEEVQFTTVLCSKIQQDPELLAYILEGKKIVGRKKACGEPTALPKDTTSHGDKDCSHDGAPAR-PQLDGESCGAQALNSHMPAETEELDGGTTESNLITSLLGLCQSKKSRVALKAQENLLLLVSMASPAAATYLVQSSACCPAIVRHLCQLYRSMPVFLDPADIATLEGISWR---LPSAPSDEASFPGKEALAAFLGWFDYCDHLITEAHTVVADALAKAVAENFFVETLQPQLLHVSEQSILTSTALLTAMLRQLRSPALLREAVAFLLGTDRQPEAPGD-NPHTLYAHLIGHCDHLSDEISITTLRLFEELLQKPHEGIIHSLVLRNLEGRPYVAWGS--------PEPESYEDTLDLEEDPYFTDSFLDSG----FQTPAKPRLAPATSYDGKTAVTEIVNSFLCLVPEEAKTSAFLEETGYDTYVHDAYGLFQECSSRVASWGWPLTPTPLDPHEPERPFFEGHFLRVLFDRMSRILDQPYSLNLQVTSVLSRLALFPHPHIHEYLLDPYISLAPGCRSLFSVLVRVIGDLMQRIQRVPQFPGKLLLVRKQLTGQAPGEQLDHQTLLQGVVVLEEFCKELAAIAFVKFPPHDPRQNVSPAPEGQV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0JPF5-1", "uniprot_id": "FHI2B_DANRE", "id": "A0JPF5-1", "name": "FHF complex subunit HOOK-interacting protein 2B", "aln": "MDMFNKVTAFLQQALETREPSINLLESFVDHWKAITNYYIETTDESRAVKNTDIPWRLRQMLDILVYEEKQQGE--EAGPCMEYLLQHKILETLCTLGKAQYPPGMSQQVMVFFSKVLSHIQKPVLHLINVYRPVQKLINLCG-LPHSQTEKEESQFLFAVCTQVNKDPYVLNYILEIK-----NDSLKRSSSTSDEAA---EKDCSGSSSPERASSPSSSSSACSLLSRSGAHPVSSPQEATG---MIPVLLHLEKSEKRRVAHRSLESLLLLVSSTQEDTGHLLAERTPLCDLLAQRLTELYLLIPSTIDPADIHSFSVVQWRTRFTQDSTAESQSFPGSENVYRFFCFLDLCNELIKQAPKVLGVKMARALHSQWLKGVIQPHLLQMSEVGILVHTTLLSCSVRHIHSPALLEELVQFMLGSDTDSETRQHLHTHLLRYRLIEHCNHISDEISITTLRLFEELLQKPNRRILSNLVLRNLENRSYKLPGTGASDERLRVESDLLDESEELEEDPFFPDMYDDSGDSNHEPLLSLPNVRERLNPNLHTQVVDTVNSFLCLVPQEAKTSHLVQGAGYDTYVHDAHKVFKECTALVRDWKWPDS-AKATVNNPSTDFYEGHFLHILFDRIARILEQPYELNLQVTSVLSRLAVFPHPNLHEYLLDPYISLSPGARSLFSTLVRVIGDLMQRIQNITNVTDRLVVIRRQLMGLDEESMVDHMTLLKGVIVLEEFCKELAAVAFVKLPTEEQ------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:.:: *:**:*: :*****:**::**:***.**:****:***. ..*:*******:**********:**. *****:******************:***** ***: ******:::*:*:** :.*:******:.* * . * ***** ** .:*:::::** :* **** * :.: ..:: ..: : :***. ..: * . . . .. *. . .. : .. :*. ** * :*:* *:* :: *.:***** :. :. *.: :. * :..:* :** :* :***** ::. :.** .:.::. :***.* : *: ::* *:.**.:* .*:. :*:*: .: : .:**:**::** .**. *:**:. :*:::*****.* : *:**:* .. : . .* * :** **:*:******:************:. : .***:***.* * *: *.: ::: :*****:*.* : *** : * . : :* *.: *********:***** ::: *********: :*:**:: * * ** : ::*. *:**:**::****::***:***.*************:****::***********:**.*****.*************.:.:...:*:::*:** * . :** ***:**:***********:****:*.. ", "identical_positions": 350, "similar_positions": 222, "identity": "45.93%" }, { "cls_id": "homologset.agr.HGNC:16493", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AE97-1", "uniprot_id": "D4AE97_RAT", "id": "D4AE97-1", "name": "", "aln": "----------------------------------------MN---SMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGS-LSVVTTVWGVTNTSQSQVLGNPMANASNPMNPGGNPMASGMSTSNPGLNSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAG--MGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPG---ISPFGTHGQRMPQQT------YPGPRPQSLPIQSIKRSYPGE--PNYGNQQYGPNSQFPTQPG-QYPTP-NPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGD-NKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSG---NTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKR----------------------------FKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGSNYQGHGNFDFPHGNPGG-TSMND---------------FMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHV-PHPSSQAGPPLHHSGAPPP------------SQPPRQPP---QAAPSNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDP-PDLPS---------NSNDDLLSLFENN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P1E1-1", "uniprot_id": "ZMIZ1_MOUSE", "id": "Q6P1E1-1", "name": "Zinc finger MIZ domain-containing protein 1", "aln": "----------------------------------------MN---SMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGS-LSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMSTSNPGINSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAG--MGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSLNPAGMAAGMTPSGMSGPPMGMNQPRPPG---ISPFGTHGQRMPQQT------YPGPRPQSLPIQSIKRPYPGE--PNYGNQQYGPNSQFPTQPG-QYPTP-NPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGD-NKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSG---NTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKR----------------------------FKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGNNYQGHGNFDFPHGNPGG-TSMND---------------FMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHV-PHPSSQAGPPLHHSGAPPP------------SQPPRQPP---QAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDP-PDLPS---------NSNDDLLSLFENN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9ULJ6-1", "uniprot_id": "ZMIZ1_HUMAN", "id": "Q9ULJ6-1", "name": "Zinc finger MIZ domain-containing protein 1", "aln": "----------------------------------------MN---SMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGS-LSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAG--MGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGP------MGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPG---ISPFGTHGQRMPQQT------YPGPRPQSLPIQNIKRPYPGE--PNYGNQQYGPNSQFPTQPG-QYPAP-NPPRPLTSPNYPGQRMPSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFS-GSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGD-NKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSG---NTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKR----------------------------FKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGG-TSMND---------------FMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHV-PHPSSQSGPPLHHSGAPPPP----------PSQPPRQPP---QAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDP-PDLPS---------NSNDDLLSLFENN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B3N1-1", "uniprot_id": "A0A8M2B3N1_DANRE", "id": "A0A8M2B3N1-1", "name": "", "aln": "----------------------------------------MNSIPSMDRHIQQTNDRLLCIKQHLQNPANFQTAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKNRQSDPQGKVPLQPPMN---SMKPSLSHGDGSFPYDSVPWQQNANQAPGS-LSVVTTVWGVTNTSQSQVLGNPMANTNNPMNPGGNALGSGMSANNPGINSPQFPGQQQQFSTKGGSNQAYMQQSMYGRPGHPGGGGFAGSYPGGPNAPSG--MGMPPHTRPPSDFTQPAAAAAAAAVAAAAATATATATATVAALQET-NKDMNQYNQVCSSFQMGPTQGYNSQFMNQPGPRGPPSMAGGMNPAAMGGGMNSSNMSGPPMGMNQPRGPG---MGPFGGHGQRMPQQG------YPGPRPQSMPMQGTKRPYPGE--PNYGGQQFGPNGQFPNQQG-QYPNP-NASRPLPSPNYPGQRMPGQQSTGQYPPTGVPMGQYYKQEPFNGQNNNFS-GGGYG-YSQG--NGPPR--QVVNYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDMKPNMTSLPPPPNNPNEELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPSVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGD-NKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASTG---NATLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQNSEFEEVNIDPTCSWRPVPIKSDIHIKEDPDGPLAKR----------------------------FKTMSPSQMIMPNVMDMIAQLGPGPSPYTPLPPQHGGNNGEYGGQGNSYQGHGNFDFPHSNSGGGAPMND---------------FMHG-PQLSHPPDVPNSLMGPDKPLAHGMPDTMPHPVSADQSHASMQPGMHASPHPNSQSAQPLHHSGPPSS-------------QPPRQPPSQQQPSQNTHPHPDMSFNPS--ADGQPGGQGPADMPEPSLDLLPELANPDELLSYLDP-PDLPS---------SSNDDLLSLFENN", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A6J3SHB9-1", "uniprot_id": "A0A6J3SHB9_DROME", "id": "A0A6J3SHB9-1", "name": "", "aln": "MSEKVEQVKESRKEKVKEEITKDDSTSVLTFDPHPYFPFLFDPYSSSKYGSQVRERKIDRCLKQLQDALNGGKKNDEMNQQAGSSRAPATGGQISPPGATTVGVEQQQHLQQQHQQQYYNQQQQQQQQQYQQQHQRDNFLAYQQQQQQQQQQQQQLQRSGGGGGNFMLGNDLVGGDSLRSLNNTFGPNSEFTSLGGANSSASSSLSGLSSSSSQGYTGMVAASQQHQQQQPHHHQQQQQQQQQQHMGSMDAMGGYSQMGGGMHPGPNSGMMGNMNGQYMNGGSGQGGYNGAQGMGMGYGGGGSMGPQRHHQMTPMNQMQNMSMGPGVGGSGGMGGGMNPLQQQAAQQQMGGMNPMAKMQGMANGGYPQQAPPSLTQQQQQQQQRRMAPYPHPQMHMAQKRAAAGVGGAGGMYPGNPMQQQQAQMYGNQQMHPGSGGGVPLPMQAGGAGNGYGRSGPMGVGNGGYGRMSAGNGMGPTGGPVMGPMGPGGMTAGGMGPGPGCMSQQRFMPQGSGGGMPGVGYGGVGGAASHQGQFYPGSGQSAGMQQAGGMCPAGPGAVATTGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVP-YVSPNPDIKP----------------PMDNSEEMRLTFPVRDGIILAPFRLLHNLSVSNHVFHLKQNVYNTLMCRNDLELQLKCFHQDDRQMNTNWPHTVTVSANATPLNIERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPYNMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGGDGGVNSLDQLNAMEKSLSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGSGNNNSSTGHNSPQTPGTPSRMGGGMGGSGSADSQQQQQEQLLNSLMSSQTQLKFSESDLSAELQSFDAAAAAINDTAHDLNLLQDVD-PMEILSYLDPQPDLNTPPSSGSSNNNASDDLLATLFD-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: * . * : :: ::**:. * . *: : .*..** : * *. ** . : : : * ::: :. : :: :: : ::* .*... *:. : : *::. . . . : *: :.: ... * ** :: . .: ** : .: : : : * * .. : * * : . *: .: *. *:. .* ** . . :.* .: *....:.. .. . :* :..:: : : . . ** :.* .: .* ..* . : *. . * . .* ** :*.: * : * . * :* * * . * .: . * .*: *. ** . * * * .: *: .* **. * .. * * :: . . * . ** ***********:**..*:* *:**. *:** * : .:*:*********::* **** ***:********: .*::*** *.*****:**:*::********* :* **.*****.***.: *.*: :**:** ********:*:*.::******************.*** * *:.*** **.: *****:*. *.:* .. : ::* * . *:******* **:******:**********:** :*.***:**** *.*:*: : **:***:*.***:: :*:.:** **.:..**.: :..: *.. :: *.***.. :*. . * . .. ... .* .. ..:..*. *.: .* . .* : . *: .*.*. .. * : .. * . .: :.: * . : .* . . : .*.*. * :* . . : * :. .. .. : . .*:** :: * *:****** *** : .:.****: : : ", "identical_positions": 305, "similar_positions": 307, "identity": "25.31%" }, { "cls_id": "homologset.agr.HGNC:16494", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9NRY7-2", "uniprot_id": "PLS2_HUMAN", "id": "Q9NRY7-2", "name": "Phospholipid scramblase 2", "aln": "-----------------------------------------------------------------------MRSWNSLFCLNS----SRPPGHIVYPKHQAGHTGKQADHLG----------------SQAFYPGRQHDYLVPPAGTAG-----IPVQN-QPGRPEG-------------VPWMPAPPPPLNCPPGLEYLSQID-MILIHQQIELLEVLFSFESSNMYEIKNSFGQRIYFAAE----DTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNC-CCCPCCLQEIEIQ----------APPGVPVGYVTQTWHPCLTKFTIKNQ--KREDVLKISGPCIVCSCIAGV--DFEITSLDEQIVVGRISKHWSGFLREAFTDADNFGIQF----------------PRDLDVKMKAVMIGACFLIDYMFFERTR---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3Z9T8-1", "uniprot_id": "D3Z9T8_RAT", "id": "D3Z9T8-1", "name": "Phospholipid scramblase", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLSTTSYESPPGLEYL---------LQQFEFVEAILGFETANQYKIKDKLGQKVYYAIE----DSNFLTRNCCGDNRPFSMRIIDNSGHEVITLQRPLRCDS-CFCPCCLQKMEVQ----------APPGVPIGYIIQTWHPCRPKFTVQNE--EKQDVLKIIGPIITCSFGGNV--DFEIKSLDEAFVVGRISKHWSGFLKEILTDVDSFGIQF----------------PLDLDVKIKAVMLGACFLIDFMFFESSRGQRPKLRLW------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DCW2-1", "uniprot_id": "PLS2_MOUSE", "id": "Q9DCW2-1", "name": "Phospholipid scramblase 2", "aln": "-----------------------------------------------------------------------MEAPRSGTYLPAGYAPQYPPAAVQGPPEHTGRPTFQTNYQV----------------PQSGYPGPQASYTVSTSGHEGYAATRLPIQNNQTIVLAN-------------TQWMPAPPPILNCPPGLEYLNQID-QLLIHQQVELLEVLTGFETNNKFEIKNSLGQMVYVAVE----DTDCCTRNCCEASRPFTLRILDHLGQEVMTLERPLKCSS-CCFPCCLQEIEIQ----------APPGVPIGYVTQTWHPCLPKLTLQND--KRENVLKVVGPCVACTCCSDI--DFEIKSLDEVTRIGKITKQWSGCVKEAFTDSDNFGIQF----------------PLDLEVKMKAVTLGACFLIDYMFFEGCE---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VT88-1", "uniprot_id": "Q9VT88_DROME", "id": "Q9VT88-1", "name": "Phospholipid scramblase", "aln": "MKSNVNQGGYAPPGFGSGFQPNAPPAEGFGYPPPTGGHNAPYPPAPGHPQPPPPTNYGFMPGPQPAGYAPVPQMPPYGEAPPYGAGQPPYMGGPGGQPPYAGGPGGQPPYVGGPGGQPHYGGGAPPPQAFGGYPPGPAGPGGPPNAFGGYPPGQPQQPIVTQPGMGPGMGPGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTID-QLLVKQKVELLEAFTGFETNNKFTIKNALGQKVYFAAE----DNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSS-CLFPCCLQSIEVS----------APPGNVIGTIEQEWSICSPSFRILNH--VGDTVMRIEGPFCTFSLCGDV--EFNVVSLTGE-KIGKISKQWSGLAREIFTDADFFGINF----------------PLDLDVRMKAVLLGATFLIDAMFFEKAGNQETDRPGML-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VZW1-1", "uniprot_id": "Q9VZW1_DROME", "id": "Q9VZW1-1", "name": "Phospholipid scramblase", "aln": "----------------------------------------------------------------------MMQMSEYKVLPQN-----------------------------------------------------------APQDENGAVVLQPQAANVGNNANGP-------------ENWMSIPVGMPNCPQGLEYLTALD-QLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYE----ESDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKCDILCCFPSCMNAVEVS----------APPGQVIGSVEQVCTFMRPKFNIKNT--CGDTVLQIEGPVCPCKCFSDT--NFKVLSANNE-EIGKISKQWSGLGRELFTDADYFSVTF----------------PLNLDVRMKALIFAALFLIDAVYYEQ-----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A8M6Z868-1", "uniprot_id": "A0A8M6Z868_DANRE", "id": "A0A8M6Z868-1", "name": "Phospholipid scramblase", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------MLPETCLSPLEVTA----------------MLSSPNPYHYPSQLEGLTRIERLFVFRDHPECIEVCCEVQPNRSYSVKDDSGNKVFSVTE----ADDCCGSQYAER--FFVMNVTDNLNREVIRLVHPSVCTR-----CSSHELEVQ----------SPPGTPIGYVRQNWHILLPKFTVENE--RGEPEFKIMGPSVFWTCCTDV--NFELVPLNAAAVERSFGRIINPSYWAGPNPGANFVLEF----------------PSSLQVKMKATVLGACILIHNMYYENKQ---------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KEL2-1", "uniprot_id": "A0A0B4KEL2_DROME", "id": "A0A0B4KEL2-1", "name": "Phospholipid scramblase", "aln": "----------------------------------------------------------------------MLQNNAVRTLQYDSEIRVAQQPSLSEPRVYDS--------------------------------------HISITSQPRPEAPRIPLPVPIATVTGS---------------RTLIPLSGYDCLADLPSVHIEQ-TFELNDVRLPFAALTGVSSENRYVVRSPLGDAIFAANE----SSTEKNRLLWGAGRPFQMHLLDKTHQEALVFRKKLAMGS---MCCQAKSLEIW----------IPPGNLLGKVVQSPTFMQPEFFIEDES-TGQLTFCVEGPVGLGFCCFSLPKDCYFKIHSGGNMRASIDHKWLASKSQ-YTTNIYFS-------------------DAKLTAKERALILGSAFLLEYLFFQTRF---------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47140-1", "uniprot_id": "AIM25_YEAST", "id": "P47140-1", "name": "Altered inheritance rate of mitochondria protein 25", "aln": "----------------------------------------------------------------------MHRTAIFLTYRSCMRNFSTLSKTLTVSSGK----------------------------------------VIRNGPFRRVIREKNQITKAPSVKAFK----------------ENSNSGIIKVHDPIATTILNEPTVIIERQIEFMNVFLGFEQANRYAIMDVNGNKIASMMERDFSITKAIMRQFYRLHRPFLVDVFDNWGNVIMTIKRPFSFINSHIKTIIPPSAYVDNGSDSTHYHDGKEGTTVGETIQNWHLWRRRYELFQKDGVEGSTFDQFGKIDAPFLSFDFP-----VTDADGKIMASVDRNWVGLGREMFTDTGVYVVRFDSQRCFDNIYPTEMLSSQVLTLDQRAVLLANAVSIDFDYFSRHSRQTGGFLSFGGGYDE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . .. . : : . *: : * * : : *: . : : : : * :* * : : : * . . : . : * :* :. . :. ::. ", "identical_positions": 10, "similar_positions": 37, "identity": "2.18%" }, { "cls_id": "homologset.agr.HGNC:16495", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JIZ9-1", "uniprot_id": "PLS3_MOUSE", "id": "Q9JIZ9-1", "name": "Phospholipid scramblase 3", "aln": "---------------------------------------------------------------------MAGYLPPKGYAPSPP----------------------------------------------------PPYPVPSGYPEPVALHPGPGQAPVPTQVPAPAPGFALFPSPGPVAPGPPAPFVPLPGVPPGLEFLVQID-QILIHQKAERVETFLGWETCNMYELRSGTGQQLGQAAEE----SNCCARLCCGARRPFRIRLADPGDREVLRLLRPLHCGC-SCCPCGLQEMEVQAPP----------GTTIGHVLQTWHPFLPKFSILDADRQPVLRVVGPCWTCGCGTDTNFEVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVD----------------LDVKVKAVLLGATFLIDYMFFEKRGGAGPSAITS------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6QBQ4-1", "uniprot_id": "PLS3_RAT", "id": "Q6QBQ4-1", "name": "Phospholipid scramblase 3", "aln": "---------------------------------------------------------------------MAGYLPPKGYAPSPP----------------------------------------------------PPYPVPAGYPEAAALHPGPGQAPVPTQGPAPAPGFSLFPSPGPVVPGPPGPFVPLPGVPSGLEFLVQID-QILIHQKAERVETFLGWETCNRYELRSGTGQQLGQAAEE----SNCCARLCCGARRPLRIRLADPGDREVLRLLRPLHCGC-SCCPCGLQEMEVQAPP----------GTTIGHVLQTWHPFIPKFSILDADRQPVLRVVGPCCTCGCGTDTNFEVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVD----------------LDVRVKAVLLGATFLIDYMFFEKRGGAGPSAITS------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NRY6-1", "uniprot_id": "PLS3_HUMAN", "id": "Q9NRY6-1", "name": "Phospholipid scramblase 3", "aln": "---------------------------------------------------------------------MAGYLPPKGYAPSPP----------------------------------------------------PPYPVTPGYPEP-ALHPGPGQAPVPAQVPAPAPGFALFPSPGPVALGSAAPFLPLPGVPSGLEFLVQID-QILIHQKAERVETFLGWETCNRYELRSGAGQPLGQAAEE----SNCCARLCCGARRPLRVRLADPGDREVLRLLRPLHCGC-SCCPCGLQEMEVQAPP----------GTTIGHVLQTWHPFLPKFSIQDADRQTVLRVVGPCWTCGCGTDTNFEVKTRDESRSVGRISKQWGGLVREALTDADDFGLQFPLD----------------LDVRVKAVLLGATFLIDYMFFEKRGGAGPSAVTS------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2BEN3-1", "uniprot_id": "A2BEN3_DANRE", "id": "A2BEN3-1", "name": "Phospholipid scramblase", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEQPYLSPAAVPPGLEYLTQID-QILVHQKIELLEAIIGFETNNQYEIKNSMGQKIFHAKEN----TDCCTRNICGPLRSFEIEIRDNFEQEVIHLSRPYRCTS-CCFPCCLQELEVQAPP----------GNPIGYIKQDWHMFKPMFSLYDMSKTKMLTIEGPLCAVSCCGDVDFDVLGKD-GNPVGRISKQWAGLIKESLTDSDNFGINFPID----------------LDVKMKAVLLGACFLIDFMFFEQTGDSGQRCSVFG-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VT88-1", "uniprot_id": "Q9VT88_DROME", "id": "Q9VT88-1", "name": "Phospholipid scramblase", "aln": "MKSNVNQGGYAPPGFGSGFQPNAPPAEGFGYPPPTGGHNAPYPPAPGHPQPPPPTNYGFMPGPQPAGYAPVPQMPPYGEAPPYGAGQPPYMGGPGGQPPYAGGPGGQPPYVGGPGGQPHYGGGAPPPQAFGGYPPGPAGPGGPPNAFGGYPPGQPQQPIVTQPGMGPGMGPGMAPQGGPAGDWMSIP-TGIPNCPRGLEYLTTID-QLLVKQKVELLEAFTGFETNNKFTIKNALGQKVYFAAED----NDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSS-CLFPCCLQSIEVSAPP----------GNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVSLT-GEKIGKISKQWSGLAREIFTDADFFGINFPLD----------------LDVRMKAVLLGATFLIDAMFFEKAGNQETDRPGML-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VZW1-1", "uniprot_id": "Q9VZW1_DROME", "id": "Q9VZW1-1", "name": "Phospholipid scramblase", "aln": "----------------------------------------------------------------------MMQMSEYKVLPQN-----------------------------------------------------------APQDENGAVVLQPQAANVGNNANGP-------------ENWMSIP-VGMPNCPQGLEYLTALD-QLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYEE----SDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKCDILCCFPSCMNAVEVSAPP----------GQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVCPCKCFSDTNFKVLSAN-NEEIGKISKQWSGLGRELFTDADYFSVTFPLN----------------LDVRMKALIFAALFLIDAVYYEQ-----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47140-1", "uniprot_id": "AIM25_YEAST", "id": "P47140-1", "name": "Altered inheritance rate of mitochondria protein 25", "aln": "------------------------------------------------------------------MHRTAIFLTYRSCMRNFS-------------------------------------------------------------TLSKTLTVSSGKVIRNGPFRRVIREKNQITKAPSVKAFKENSNSGIIKVHDPIATTILNEPTVIIERQIEFMNVFLGFEQANRYAIMDVNGNKIASMMERDFSITKAIMRQFYRLHRPFLVDVFDNWGNVIMTIKRPFSFINSHIKTIIPPSAYVDNGSDSTHYHDGKEGTTVGETIQNWHLWRRRYELFQKDGVEGSTFDQFGKIDAPFLSFDFPVTDAD-GKIMASVDRNWVGLGREMFTDTGVYVVRFDSQRCFDNIYPTEMLSSQVLTLDQRAVLLANAVSIDFDYFSRHSRQTGGFLSFGGGYDE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : ::: :: * :: : *:* * : : . *: : * ... * *.: : : * . :: : ** . *. . * :* * : : : . . :* * .. :. :.::* ** :* :**:. : : * : * : :*:::. . ** ::.: ", "identical_positions": 28, "similar_positions": 64, "identity": "6.15%" }, { "cls_id": "homologset.agr.HGNC:16496", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91WC3-1", "uniprot_id": "ACSL6_MOUSE", "id": "Q91WC3-1", "name": "Long-chain-fatty-acid--CoA ligase 6", "aln": "-MQTQEILRILRLPELSDLGQFFRSLS--------ATTLVSVGALAAVLAYWLTHRPKALQPPCNLLKQSEEVEDGGGARRSVIGGCTQ---LLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQ-------PYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFVG------VFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSISYIINTADICTVIVDKPHKATLLLEHVERKETPGLKLVILMEPFEDALRER--------GKKCGVDIKSMQAIEDCGRENHHAPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVL-ISFLPLAHMFERVIQSVVYCHGGRVGFFQG-DIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTS-LKRWLLEFAAKRKQAEVRSG-----IIRNNSIWDELFFNKIQASLGG-HVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTCKGE-GEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSE-PVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKKGIEG---TYQELCMKKELKKAILDDMVMLGKES--GLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYLVSV-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P33124-1", "uniprot_id": "ACSL6_RAT", "id": "P33124-1", "name": "Long-chain-fatty-acid--CoA ligase 6", "aln": "-MQTQEILRILRLPELSDLGQFFRSLS--------ATTLVSMGALAAILAYWLTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGDCTQ---LLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQ-------PYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFIG------VFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSIRYIINTADICTVIVDKPHKAILLLEHVERKETPGLKLVILMEPFDDALRER--------GKKCGVDIKSMQAIEDSGQENHRVPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVH-FSYLPLAHMFERMVQSVVYCHGGRVGFFQG-DIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTS-LKRWLLEFAAKRKQAEVRSG-----IIRNNSIWDELFFNKIQASLGG-HVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTSKGE-GEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSE-PVAQIYVHGDSLKAFLVGIVVPDPEVMPCWAQKKGIEG---NYQELCKSKELKKAILDDMVMLGKES--GLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UKU0-4", "uniprot_id": "ACSL6_HUMAN", "id": "Q9UKU0-4", "name": "Long-chain-fatty-acid--CoA ligase 6", "aln": "-MQTQEILRILRLPELGDLGQFFRSLS--------ATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQ---LLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQ-------PYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIG------VFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKER--------GQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVL-ISFLPLAHMFERVIQSVVYCHGGRVGFFQG-DIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTP-LKRWLLEFAAKRKQAEVRSG-----IIRNDSIWDELFFNKIQASLGG-CVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGE-GEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQ-PVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEG---TYADLCTNKDLKKAILEDMVRLGKES--GLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VVT8-1", "uniprot_id": "Q9VVT8_DROME", "id": "Q9VVT8-1", "name": "Long-chain-fatty-acid--CoA ligase", "aln": "MTPEKSVMAYVNHLIVSNFSYFWDEIDGYLYYLGGTLGTLTLGSLAASVAYYFATRPVPERPLVPLENQSPLLEGPEQIHVSKFYKESKNGKFVSYITENVRTLYQTFREGAYASNNGPCLGWRETLTS------PYQWINYDEALLRAKNFGAGMLALGARP--KQLIG------IYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTDMQVVIVEDDGKAAMLLEKAPR----SLKIIVAIKPIRQTTLER--------ARSRGIQIFSFIDVEKLGAKGNHPEVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSVILQMGDHRIR-AGDVM-VSFLPLAHMFERCCENGMYYVGGCVGFYSG-DIKELTNDLKMLKPTVMPAVPRLLNRVYDKIQNDISASGLKRGLFNMAMRAKEKEIARG-----VLRRNGCWDKLVFKKVHQAFGG-NLRLMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDVPEMEYFANQNT-GEVCVRGSNVFHGYYKDPEKTAEAIDSEGWHHTGDVGMWLPNGTLRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQ-YVNQVYVYGESLKSCIIAVVVPDTDVLKQWATENNVRG---TLSVLCNNKNVKELIMNDMLNWGKQS--GLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDMYKHLD-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39518-1", "uniprot_id": "LCF2_YEAST", "id": "P39518-1", "name": "Long-chain-fatty-acid--CoA ligase 2", "aln": "-MAAPDYALTDLIESDPRFESLKTRLAG--------YTKGSDEYIEELYSQLPLTSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSSLSSENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : : : : : :. : . * . ::: .: ** *: * . : *** * .::: .*. . *.. :*:*:* : . : ::*.****: : .* ::*:. ..**:****.: :*:. :: :*. . :* * : : :. . . : : *: :*. * .: :** .:.* :.:****** ***. ::* *:.:... : :: ..:*****:*** * :** * * :*:* * * .. ***:*.*. * . . ::* : : *. .. : . :..:.:.*:: ::* :::.*:** : .* *:*.**. : :*** ** .. :: : . *. . :* .. *: * : :. **: ::*.:**. * *: :.* :*:*.:** ***:. * : :*** *::***::***:.******** * : *::*.*:.**: ::.:* * :. . . . * . : :: : .::: ::. **:.**::: * : : :::::.::***:* **.: .:** ::::* ", "identical_positions": 149, "similar_positions": 227, "identity": "19.79%" }, { "cls_id": "homologset.agr.HGNC:16497", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P58196-1", "uniprot_id": "PLS4_MOUSE", "id": "P58196-1", "name": "Phospholipid scramblase 4", "aln": "MSGLVPTAPEQPTEEMENQIKSPTAVPDAPPDYNSHFAPGPAGPVASP----SAGLPMGYYIPQQPGAIPLYHPTGGTHPIQYQPGKYPVTNQPAPIMWMAGPAPVPNCPPGLEYLAQ---------------------------------LDNIHVLQHVEPLELMTRFETNNRYDIKNNIDQMVYIVTED----TDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCT---------CCCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFEINSLDGVSNIGSIIRKWN-GFLSTMVNADHFEIRFP----------------LALDVKMKAMIFGSCFLIDFMYFERPPPRRMSR---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0M2G4-1", "uniprot_id": "A0ABK0M2G4_RAT", "id": "A0ABK0M2G4-1", "name": "Phospholipid scramblase", "aln": "MSGVVPTAPEQPTEEAENQVKATTAVPDAPPDYNSHFVPGPAGPAAPP----SAGLPMGYYVPQQPGAIPLYHPTGGTHPIQYQPGKYPLTSQPAPIMWMPGPAPMPNCPPGLEYLAQAFRSDYNESHLESPISVPNEISKDFETQNLLEKLDNIHVLQHLEPLELMTRFETNNRYDIKNNVDQMVYIVTED----TDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCT---------CCCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESAMRVRGPCATYGCGSDSVFEVNSLDGASNIGSIIRKWN-GFLSTMGNADHFEIRFP----------------LALDVKMKAMIFGCCFLIDFMYFERPPPRRSSR---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NRQ2-1", "uniprot_id": "PLS4_HUMAN", "id": "Q9NRQ2-1", "name": "Phospholipid scramblase 4", "aln": "MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQ---------------------------------LDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTED----TDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCT---------CCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWN-GLLSAMADADHFDIHFP----------------LDLDVKMKAMIFGACFLIDFMYFERSPPQR-SR---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z868-1", "uniprot_id": "A0A8M6Z868_DANRE", "id": "A0A8M6Z868-1", "name": "Phospholipid scramblase", "aln": "----------------------------------------------------------------------------------MLPETCLSPLEVTAMLSSPNPYHYPSQLEGLTRIER-----------------------------------LFVFRDHPECIEVCCEVQPNRSYSVKDDSGNKVFSVTEA----DDCCG--SQYAERFFVMNVTDNLNREVIRLVHPS---------------VCTRCSSHELEVQSPPGTPIGYVRQNWHILLPKFTVENERGEPEFKIMGPSVFWTCCTDVNFELVPLNAAAVERSFGRIINPSYWAGPNPGANFVLEFP----------------SSLQVKMKATVLGACILIHNMYYENKQ---------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P47140-1", "uniprot_id": "AIM25_YEAST", "id": "P47140-1", "name": "Altered inheritance rate of mitochondria protein 25", "aln": "MHRTAIFLTYRSCMRNFSTLSKTLTVSSGKVIRN-----------------------------------------GPFRRVIREKNQITKAPSVKAFKENSNSGIIKVHDPIATTILN---------------------------------EPTVIIERQIEFMNVFLGFEQANRYAIMDVNGNKIASMMERDFSITKAIMRQFYRLHRPFLVDVFDNWGNVIMTIKRPFSFINSHIKTIIPPSAYVDNGSDSTHYHDGKEGTTVGETIQNWHLWRRRYELFQKDGVEGSTFDQFGKIDAPFLSFDFPVTDADG-KIMASVDRNWVGLGREMFTDTGVYVVRFDSQRCFDNIYPTEMLSSQVLTLDQRAVLLANAVSIDFDYFSRHSRQTGGFLSFGGGYDE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . .: ... : . . . : * ::: .: . * : : .: : : * . * *:: * * .. :: : :* : : *..:* . ::*:: : : :: . . * : :. *. * : :.* * :. :* ::. .. *. *:.. ", "identical_positions": 19, "similar_positions": 68, "identity": "4.73%" }, { "cls_id": "homologset.agr.HGNC:16499", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96DA2-1", "uniprot_id": "RB39B_HUMAN", "id": "Q96DA2-1", "name": "Ras-related protein Rab-39B", "aln": "-MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLD---TQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFV-PNVVHSSEEVVKSERRCLC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8BHC1-1", "uniprot_id": "RB39B_MOUSE", "id": "Q8BHC1-1", "name": "Ras-related protein Rab-39B", "aln": "-MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLD---TQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFV-PNVVHSSEEVIKSERRCLC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9W3Q0-1", "uniprot_id": "Q9W3Q0_DROME", "id": "Q9W3Q0-1", "name": "", "aln": "MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPNSLDFNLVVAEPEKSSCC", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*.*: ******:*********.*:: **:*:**::**********:**:*:: *.:****:*************::******* **::**:*: **::: *: *:: *::*:: **.*** * ** :*:** .**:*:* :*::::*****.. ***:** :*:::* :: ** . ::**:*:**** ** :. . * :.*: . *", "identical_positions": 114, "similar_positions": 66, "identity": "52.29%" }, { "cls_id": "homologset.agr.HGNC:165", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R4I6-1", "uniprot_id": "Q8R4I6_RAT", "id": "Q8R4I6-1", "name": "", "aln": "MMMVMQPEGLGAGEGPFSGGGGG-EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGDHQLLQEGLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLG-----EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88990-1", "uniprot_id": "ACTN3_MOUSE", "id": "O88990-1", "name": "Alpha-actinin-3", "aln": "MMMVMQPEGLGAGEGPFSGGGGG-EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLG-----EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q08043-1", "uniprot_id": "ACTN3_HUMAN", "id": "Q08043-1", "name": "Alpha-actinin-3", "aln": "MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQA----------------------ETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLG-----EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P18091-3", "uniprot_id": "ACTN_DROME", "id": "P18091-3", "name": "Alpha-actinin, sarcomeric", "aln": "-MMMENGLSMEYGDG----------YMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **: : .: *:* ******:*:*: **********:**************** *:********************** **:**:***********************:************************************* :****************:******** *:*****:***************** **:*: ******:*********:***.:*::*******:********:**** **:*. *********** ******:******:***:********:***:.* .: *::.:*:***::* *** *****:::*.:** ************:***::*:*** ****:*:*:*** .**.:*:***:* **:**:***:**::**. ** *********..:*: .. *:*::** ::****************:***:***** *:**:..***:*** ******.**:***:** **:. *::**.** *:****:***********: *** *:::**::** *.*: **:****** ***:* . *:.: *::.* : : : *** **:.:*:. **. **:***. **** :** :** ** ****** :** :****: ::: * :. ** ****:*: *:: ** : **.**:.** ** :**.::*:*::* *:** :*********** *.*******:****:**:*********:******:::.* :.*::*::**:*:**.:* :::* **:::**** :* * *:**:******:::***:***: **:***.** ** *:*******..******:** ****... .*****::**:*****:**", "identical_positions": 605, "similar_positions": 197, "identity": "65.19%" }, { "cls_id": "homologset.agr.HGNC:16500", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QXT1-1", "uniprot_id": "DAPP1_MOUSE", "id": "Q9QXT1-1", "name": "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide", "aln": "MGRAELLGGNMSTQDPSELWGRADGGTDLLQDLGWYHGNLTRHAAEALLLSNGRDGSYLLRDSNEQTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEYSSLKDFVKHFANQPLIGSETGTLMVLKHPYPREVEEPCIYESVRVHTAMQTGRTENDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLQRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSKIRKQLDQGEDTVRSRSFIFK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ACC1-1", "uniprot_id": "D4ACC1_RAT", "id": "D4ACC1-1", "name": "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide", "aln": "MGRAELLGGNMSTQDPSELWGRADGGSDLFQDLGWYHSNLTRHAAEALLLSNGRDGSYLLRDSNEQTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEYSSLKDFVKHFANQPLIGSETGTLIVLKHPYPRQVEEPSIYESVRVHTAMQTGRTENDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLQRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQDRVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSKIRKQLDQ-DDTIRSRSFIFK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UN19-1", "uniprot_id": "DAPP1_HUMAN", "id": "Q9UN19-1", "name": "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide", "aln": "MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******* *:*******:**.*:** ::*:*******.*************** *********** ********************************:***********************:********:****.*****************:*********************************:*********************************:************************************:*****:* :.*:********", "identical_positions": 255, "similar_positions": 20, "identity": "91.07%" }, { "cls_id": "homologset.agr.HGNC:16501", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P70271-1", "uniprot_id": "PDLI4_MOUSE", "id": "P70271-1", "name": "PDZ and LIM domain protein 4", "aln": "MTHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSAPDD-KAQAHRIHIDPESQDCSPATSRRSSVSGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEATLPAQMSALHVSPPTSADTARVLPRNRDCRVDLGSEVYRMLREPAEPTASEPKQSGSFRYLQGMLEAGEGGDRPGSGGPRNLKPAASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCENHAKARVKPPEGYDVVAVYPNAKVELV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P36202-1", "uniprot_id": "PDLI4_RAT", "id": "P36202-1", "name": "PDZ and LIM domain protein 4", "aln": "MTHAVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDSIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSSPND-KAQAHRIHIDPEAQDGSPATSRRSSISGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEVTLPSQMSALHVSPPPSADTPRILPRNRDCRVDLGSEVYRMLREPAEPAASEPKQSGSFRYLQGMLEAGEGGDRPGSGGSRNLKPAASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCENHAKARVKPPEGYDVVAVYPNAKVELV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P50479-1", "uniprot_id": "PDLI4_HUMAN", "id": "P50479-1", "name": "PDZ and LIM domain protein 4", "aln": "MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSS-EATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPPEGYDVVAVYPNAKVELV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.*:******************************************* ************************************.:.***:*:* ************ ** **:****.* :* . **.*..**********:******** *.***:***:******.***..* ***.*********************.*:********************** **.**.*****:*****************************************************************.**************************", "identical_positions": 293, "similar_positions": 28, "identity": "88.52%" }, { "cls_id": "homologset.agr.HGNC:16502", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AAW6-1", "uniprot_id": "D4AAW6_RAT", "id": "D4AAW6-1", "name": "Rhomboid-related protein 3", "aln": "-------------------------MG-----EHPSPGPAVAACAEAERIEELEP----------------------------------------EAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFRSLLES--HSSKLDPHKKEVLLALAD----SHADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSS--KALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITLLEART-RVALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHP--------------SFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIF-AYTLLDLKLPPPP-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P58873-1", "uniprot_id": "RHBL3_MOUSE", "id": "P58873-1", "name": "Rhomboid-related protein 3", "aln": "-------------------------MG-----EHPSPGPAVAACAEAERIEELEP----------------------------------------EAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFRSLLES--HSSKLDPHKKEVLLALAD----SHADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSS--KALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITLLE-----VALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHP--------------SFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIF-AYTLLDLKLPPAP-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P58872-1", "uniprot_id": "RHBL3_HUMAN", "id": "P58872-1", "name": "Rhomboid-related protein 3", "aln": "-------------------------MG-----EHPSPGPAVAACAEAERIEELEP----------------------------------------EAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLES--HSSKLDPHKREVLLALAD----SHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSS--KALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLE-----VAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHP--------------SFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIF-AYTLLDLKLPPPP-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W0E9-1", "uniprot_id": "Q9W0E9_DROME", "id": "Q9W0E9-1", "name": "", "aln": "-------------------MWPGSERGSSRALEIPTSQQNAGGSSQQETLADIEHISTIAGSLASIGSLSHTQMRYQCTNDAGYDTEHTSLNSDFDEAELRRELLRDKWKLLFDMFDPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLPTGPGYVTFQDFVNVMSGKRTRSFKCAVHHRDREVCSENDFQLVLNEPPLFRKMVHAVAMEILPEERDRKYYADRYTCCPPPFFIILVTLVE-----LGFFVYHSVVTGEAAPRGPIP--SDSMFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNYHQMR--YGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEFLAIDQAETAGAVSYVAHLAGAIAGLTIGLLVLKSFEQKLHEQLLWWIALGTYLALVVFAIAFNIMNGFAMFNIRVEKIRVT-ETIFNDFQV-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W0F8-1", "uniprot_id": "Q9W0F8_DROME", "id": "Q9W0F8-1", "name": "rhomboid protease", "aln": "-----------------MLLLSG------------------------------------------------------------------------APSQGR----RPKNRPLIGTVEEGEMPPSTVLQMPPAPLS-------------------------SKSGLVLGVCCDQLMAVQPVQRASGAAATKS------------------------NSPDWGNHRAKHHEGSAAPFKWIPP-FFIILATLLE-----VLVFLWVG-----------ADPPEDSLLVYRPDQRLQLWRFLSYALLHASWLHLGYNVLTQLLFGVPLELVHGSLRTGVIYMAGVLAGSLGTSVVDSEVFLVGASGGVYALLAAQLASLLLNFGQMR--HGVIQLMAVILFVFCDLGYALYSRELAMHQLQTRPS-------------VSYIAHMTGALAGISVGLLLLRQLDGGLRPRPLRWLALGVWCIFSAFGIAFNLVNTVTAQLLAEEEGQVIRQHLMNDLGMG", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P20350-1", "uniprot_id": "RHOM_DROME", "id": "P20350-1", "name": "Protein rhomboid", "aln": "-----------------MENLTQ------------------------------------------------------------------------NVNETKVDLGQEKEKEASQEEEHATAAKETIIDIPAACSS-------------------------SSNSSSYDTDCSTASSTCCTRQGEHIYMQRE------------------------AIPATPLPESEDIGLLKYVHRQHWP-WFILVISIIE-----IAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMK--SASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQ-------------VSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIVFNLINTVTAQLMEEQ-GEVITQHLLHDLGVS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VYW6-1", "uniprot_id": "Q9VYW6_DROME", "id": "Q9VYW6-1", "name": "", "aln": "MPVKTVNRQQSQTPAQQLQLQQQRDVENGLYPTIPAERRSPPSRPQTLRQDTIDMEEIP-----------------------------------LNQTNSQEPEDRRKMHEIFDKHDSDRDGLINTHELKELISDG-YCRDIPAYIADQILKRSD----QDNDGHLDFEEFYAMSLRHKWMVRNMLTRYCRYVVP----------------------PPKPLEGDEPDGAYEKQMSICPPPLTMVLFSIIEIIMFLVDVIHFQDDPNYQDRIGESTSGPAATLFIYNPYKRYEGWRFVSYMFVHVGIMHLMMNLIIQIFLGIALELVHHWWRVGLVYLAGVLAGSMGTSLTSPRIFLAGASGGVYALITAHIATIIMNYSEME--YAIVQLLAFLVFCFTDLGTSVYRHLTDQHDQI------------------GYVAHLSGAVAGLLVGIGVLRNLEVRRWERILWWVAVIVYFALMTTGIIIHVFVPDYFPKQEYN----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q86BL6-1", "uniprot_id": "Q86BL6_DROME", "id": "Q86BL6-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------MSAQVESNGASESNNNCVKDVRLLLLP-------------------------ENSTDSDGNPASVAFSAESHKKF-----------------------------------IDDLTRTIDVGHVRRKRLWRVP-WFILLMSFVQ------------------ISLHWIASECMQKVLIFKPEWNVEYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLMGASAGVYAMLGSHVPHLVLNFSQLS--HRFARIASLLILLLSDVGFTTYHFCHNHNRNPR----------------TSLEAHIGGGVAGILCGFIVYRRLQPANQKAIYF-----------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. * :: :::: . :::.* . : ** . * .:* . :* *: * ..*: **: : * . :*. * .***:. : . : *:*.****:: :::. : :*: : :: :: :.* : : . **: * .*: *. : : ", "identical_positions": 31, "similar_positions": 62, "identity": "6.02%" }, { "cls_id": "homologset.agr.HGNC:16503", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AD20-1", "uniprot_id": "D4AD20_RAT", "id": "D4AD20-1", "name": "Bactericidal permeability-increasing protein", "aln": "MRTKQVPVLGACFLLWSLYIASSQTVYPGIKARITQRALDYGLQVGMEILEQLAKEIVIPDLNGSESLKFLKIDYVKYNFSNIKINAFSFPNTSLAFVPGVGIRALSNHGTANISTNWDVKAPLFQDSGAADLFLSGIYFTGIIVFTRNDFGHPALELQDCHVQVSHARVSFSGGLSVLYNSFAEPMEKPILKNLNEMVSLCPIAISQVEEFNVNISALEVLTKIDNYTVLDCSLISPPEVTENHLDFHLKGAFYPLESLVDPPFTPAPFELPESRDSMLYIGVSEYFFKSASFAHFVSGALGTVLSTREISNYFNQNAQGIGSVLSKIAEIYILSQPFMLQIMATGPPVVNLHPNNFSLELPAAVIMLTQPENSTIQPIVSMDFVASTSVGLAILGQKLICSLSLNRFRLSLPENSPRDIKVVRFENILSSILHFGVLPLANTKLQQGFPLPNPYNISFVNSDIEVLEGFLLISTDVAHETSSKQQPNLHSWGHLNMVHGPRKKQPIH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C186-1", "uniprot_id": "BPIFC_MOUSE", "id": "Q8C186-1", "name": "BPI fold-containing family C protein", "aln": "MRTKQVPVLWACFLLWSLYIASSQTVYPGITARITQRALDYGLQVGMKVLEQLAKEIVIPDLNGSESLKFLKIDYVKYNFSNIKINAFSFPNTSLAFVPGVGIRALSNHGTANISTNWSVKAPLFRDSGAANLFLSGIYFTGIVAFTRNDFGYPALELQDCHVQVSHARVSFFGSLSALYNSFAEPMEKPILKNLNEMVQLCPIAISQVEQFNVNISALEVLTKIDNYTVLDCSLISPPEITENHLDFNLKGAFYPLESLVDPPFTPAPFHLPESRDSMLYIGISEYFFKSASFAHYVSGALGTTLSTREISNYFSQNVQGFGSVLSKIAEIYVLSQPFILQMMATGPPMVNLQRNNFSLEFPAAVIMLTQLDNSTIQPIVSMDFVASTSVGLAILGQKLICSLSLNRFRLSLPENSQRDAKVVRFENILSSILHFGVLPLANTKLQQGFPLPNPYNISFINSDIEVLEGYLLVSSDLAYDTSSKPQPNLNSWGDLNLVHRPWREQPTH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFQ6-1", "uniprot_id": "BPIFC_HUMAN", "id": "Q8NFQ6-1", "name": "BPI fold-containing family C protein", "aln": "MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEM--LCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* ** :*** .*****.**::****:****.***********:*.**:::**: ** :***.*****:***:***:********.*****************:**:*********:*..::***:*:*.*:*****:*****: :******:*:*:****:.*:***:*** * **.******************** **** *:*: :*.*:*:***********:** ****.**:***:**::***.*****.*.****:*.** *** :******::***********:.:*.:...***.****:* ** **:*.***:*****:*****::::*** **::**: .**:*::**:::**** .***::.**************.****:*:**********:***.. : :*:*******************:********.**::: *:*********:**:*:*: ::**** **.:: * **:: : :. ", "identical_positions": 348, "similar_positions": 122, "identity": "68.37%" }, { "cls_id": "homologset.agr.HGNC:16504", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AB30-1", "uniprot_id": "D4AB30_RAT", "id": "D4AB30-1", "name": "", "aln": "MQWSLCLVLCGLLAGTQADPGALLRLGMDIMNHEVQTAMEESHILEKMAAEASNPQTGGKAIKGLSNMKVKDVLEPVITLNFVPGVGIFQCVSTGMTITGKSFTGGNMEINVVLNITATDRILQDEETGTPVFRSEGCEVILVNVKTNLPNN---KAINKFVDSTLRKVLPGLMCPAIDAVLVYVNKKWTNLTDPMPVDRMGTVKYALTSPPATTASHIQVDFSPVVQLQEGQLIPLATNGSSPEFPEGSAK-DSQLLLSDTFLTAELALLQKSLEVNLKDKRVRKLS-QTTRTLAGFIPQVAKSYHKPKPLLIKVKINKPPKVTMKAGKSLMHLHGSLEMFAARRHGKHPKSLFRLETHIGLEIHYSVHENRLQMATSLDSLLSLSRESSSIGDFQETALTGFITDYLQKAYIPVVNDVLHVGLPLPDLLAIDYNLSELDVVEDALVLSLKME", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BU51-1", "uniprot_id": "BPIB6_MOUSE", "id": "Q8BU51-1", "name": "BPI fold-containing family B member 6", "aln": "MLCSLSLVLCGLLAGTRADPGGLLRLGMDIMNHEVQSAMEESHILEKMAAEASNPQPGGKAIKGLSNMKVKDVLEPVITLNFVPGVGISQCVSTGMTITGKSFTGGNMEINVVLNITATDRLLQDEEAGTPVFRSEGCEVILVSVKTNLPNN---KAINKFVDSTLRKVLPGLMCPAIDAVLEYVNKKWAKLTDPMPVDKMGTVKYALTSPPATTASHIQVDFSPVVQLQEGQLIQLATDGSLPEFPEGSAK-DSQLLLSATFLTAELALLQKSLEVKLKDKRVGKLP-QNTRTLAGFIPQVAKTYHKPKPLLIKVKINKPPKVTMKAGKSLMHLHGSLEMFAARRHGKHPKSLFRLETHIGLEIHYSVQDNRLQMVTSMDSLLSLARESSSVGDFHEAELTGFITDYLQKAYIPVVNDVLHVGLPLPDLLAINYNLAELDIVEDALVLGLKTE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFQ5-1", "uniprot_id": "BPIB6_HUMAN", "id": "Q8NFQ5-1", "name": "BPI fold-containing family B member 6", "aln": "MLRILCLALCSLLTGTRADPGALLRLGMDIMN-QVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLKLG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *.*.**.**:**:****.********** :**:**:************.: *.* *.***::*:***** ************* ********:***** ****** *.******:*:*:***:* ***:*********.******.* * :***:****:*************** ***:**::*:*****.:******.* *.******:**:******* *:*: * ** *. **** ** .*****. ***:*********:.*:::*. : :*. *.*:*** ***:** :* *.*** ::**:********:****:***.:******* :.* * *** **.*:.*:::***::*:***.**:* ****:*:***:*:*:* ******.**::**********:*******:**::***:***:**:**:*.** ", "identical_positions": 313, "similar_positions": 95, "identity": "68.94%" }, { "cls_id": "homologset.agr.HGNC:16505", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q921A4-1", "uniprot_id": "CYGB_RAT", "id": "Q921A4-1", "name": "Cytoglobin", "aln": "MEKVPGDMEIERRERNEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLH---DPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILDVIAEEFANDFP-VETQKAWTKLRGLIYSHVTAAYKEVGWVQQVPNTTTLPATLPSSGP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CX80-1", "uniprot_id": "CYGB_MOUSE", "id": "Q9CX80-1", "name": "Cytoglobin", "aln": "MEKVPGDMEIERRERSEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFRHMEDPLEMERSPQLRKHACRVMGALNTVVENLH---DPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILEVIAEEFANDFP-VETQKAWAKLRGLIYSHVTAAYKEVGWVQQVPNTTTPPATLPSSGP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WWM9-1", "uniprot_id": "CYGB_HUMAN", "id": "Q8WWM9-1", "name": "Cytoglobin", "aln": "MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLH---DPDKVSSVLALVGKAHALKHKVEPVYFKILSGVILEVVAEEFASDFP-PETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q575S8-1", "uniprot_id": "CYGB2_DANRE", "id": "Q575S8-1", "name": "Cytoglobin-2", "aln": "MEKEREDEETEGRERPEPLTDVERGIIKDTWARVYASCEDVGVTILIRFFVNFPSAKQYFSQFQDMEDPEEMEKSSQLRKHARRVMNAINTVVENLH---DPEKVSSVLVLVGKAHAFKYKVEPIYFKILSGVILEILAEEFGECFT-PEVQTSWSKLMAALYWHITGAYTEVGWVKLSSSAV-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8UUR3-1", "uniprot_id": "CYGB1_DANRE", "id": "Q8UUR3-1", "name": "Cytoglobin-1", "aln": "ME---GDGGVQLTQSPDSLTEEDVCVIQDTWKPVYAERDNAGVAVLVRFFTNFPSAKQYFEHFRELQDPAEMQQNAQLKEHGQRVLNALNTLVENLR---DADKLNTIFNQMGKSHALRHKVDPVYFKILAGVILEVLVEAFPQCFSPAEVQSSWSKLMGILYWQMNRVYAEVGWENSKK--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VF15-1", "uniprot_id": "Q9VF15_DROME", "id": "Q9VF15-1", "name": "", "aln": "------------------MNSDEVQLIKKTWEIPVATPTDSGAAILTQFFNRFPSNLEKFP-FRDVP-LEELSGNARFRAHAGRIIRVFDESIQVLGQDGDLEKLDEIWTKIAVSHIPR-TVSKESYNQLKGVILDVLTAACSLDES---QAATWAKLVDHVYGIIFKAIDDDGNAK-----------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. : :: * * : *.::* :** .*** : * *:.: *:. ..::: *. *:: .:: :: * * :*:. : :. :* : .*. :: * ****:::. . :*:** :* : . : * : ", "identical_positions": 29, "similar_positions": 55, "identity": "14.95%" }, { "cls_id": "homologset.agr.HGNC:16507", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8TBG9-1", "uniprot_id": "SYNPR_HUMAN", "id": "Q8TBG9-1", "name": "Synaptoporin", "aln": "MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQ-RYLSDPMEKHSSSYNQGGYNQDSYGSSSG-YSQQASLGPTS-DEFG-QQPTGPTSFTNQI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P22831-1", "uniprot_id": "SYNPR_RAT", "id": "P22831-1", "name": "Synaptoporin", "aln": "MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQ-RYLSDPMEKHSSSYNQGGYNQDSYGSSGG-YSQQASLGPTS-DEFG-QQPSGPTSFNNQI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGN8-1", "uniprot_id": "SYNPR_MOUSE", "id": "Q8BGN8-1", "name": "Synaptoporin", "aln": "MCMVIFAPLFAMFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLQQVTFEVPTCEGKEQQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQ-RYLSDPMEKHSSSYNQGRYNQESYGSSGG-YSQQANLGPTS-DEFG-QQPSGPTSFNNQI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M9PVE4-1", "uniprot_id": "A0A8M9PVE4_DANRE", "id": "A0A8M9PVE4-1", "name": "", "aln": "MCMVIFAPLFAIFAFATCGGYSGQMRVSVDCINKSDSNLSIAINFAYPFRLNQVEFDVPMCEGRRQERLYLIGDFSSSAEFFVTIAVFSFLYSLLATVVYIFFQNKYRENNRGPLIDFIVTVVFSFMWLVSSSAWAKGLSDVKAATDPDEVVLLVSACKVQTNKCSSLYGPRWSGLNTSVVFGYLNFVLWAGNIWFVFKETGWHKGGAARYPASSLEKQTTAFNQQVYNQGSFDQSGATFTGTGDFAQSEYSQVGNYSSSGPISYTNQ-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***********:*********** :*:****:**::***** * *******:** *:** ***:.:::* *:** *********:***:***** *******************************:***.************.****.**:**:**** :*** :::.* *.********:***:****************..* ** :..:**:::::** *** *:..*.. :: ..:. :. .:.* ..:** *:.** ", "identical_positions": 179, "similar_positions": 62, "identity": "66.54%" }, { "cls_id": "homologset.agr.HGNC:16508", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62739-1", "uniprot_id": "RAB3I_RAT", "id": "Q62739-1", "name": "Rab-3A-interacting protein", "aln": "------------------------------------------------------------------------------------------------------------------MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPHPSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISN-ISIHVPEPASSVASEVAAGLTRFTSRKDSCNAEREFLQGATVTEASAG----------------------------NDDIFGLSTDSLSRLRSPS-VLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATAEKQLK-----------------EAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNK-----------------------------STSSAMSGSHQD------------------------------FSAIQPIVKDCREADLS-----LYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLT---------FAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPK--------------KCALTGQSKPCKHRIKLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL---------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q68EF0-1", "uniprot_id": "RAB3I_MOUSE", "id": "Q68EF0-1", "name": "Rab-3A-interacting protein", "aln": "------------------------------------------------------------------------------------------------------------------MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPHPSTLCAAPLQANALDLSDLPTQPVYSSPRHFNCAEVSN-ISAHAPDPASSVPSAVASGLTKLTSRKDSCNAEREFLQGATITEASAG----------------------------NDDIFGLSTDSLSRLRSPS-VLEVREKGYERLKEELAKAQR--------------------------------EAHKMVREANVKQATAEKQLK-----------------EAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAAKTPFKRGHTRNK-----------------------------STSSAMGGSHQD------------------------------LSVIQPIVKDCKEADLS-----LYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLT---------FAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPK--------------KCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL---------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96QF0-1", "uniprot_id": "RAB3I_HUMAN", "id": "Q96QF0-1", "name": "Rab-3A-interacting protein", "aln": "--------------------------------------------------------------------------------------------------MGLKKMKGLSYDEAFAMANDPLEGFHEVNLASPTSPDLLGVYESGTQEQTTSPSVIYRPHPSALSSVPIQANALDVSELPTQPVYSSPRRLNCAEISS-ISFHVTDPAPCSTSGVTAGLTKLTTRKDNYNAEREFLQGATITEACDG----------------------------SDDIFGLSTDSLSRLRSPS-VLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLK-----------------EAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNK-----------------------------STSSAMSGSHQD------------------------------LSVIQPIVKDCKEADLS-----LYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLT---------FSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPK--------------KCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL---------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58J6L5-1", "uniprot_id": "A0AC58J6L5_DANRE", "id": "A0AC58J6L5-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------MKIFWAMASEPLEGFHEVNLASPTTPDVHGVIDPSPPKHNAPPSTLYRTHS--LSSSQNAASALRADQLPTQPVYSAPRHLGGDDTLN-GSGNDP---------------------------------AAVDAVDAD----------------------------GEDGLGLSTDGLSRLRSPS-VMEVREKGYEKLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVHEANLKQATAEKQLK-----------------EALGKIDVLQAEVAALKTLVLSTSPTSPCKEMPPGPKAPFKKGHVRNK-----------------------------STSSAMLGSQQE------------------------------VAVTQPIVRECKEVDSL-----LFTEFKAWKEEPTLERSCSFLERIYREDIYPCLT---------FSKSELGSAILEAVEQNTLSVEPVGFQPLPVVRASAVECGGPKMAE--------TLVKCALCGQTKTCKHRIKFGDSSSYYYVSPFCRYRITSVCNFFTYIRYILQGLVKQQDAEQMFWEVLQLRKEMSNAKLGFYKDEL---------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P17065-1", "uniprot_id": "SEC2_YEAST", "id": "P17065-1", "name": "Rab guanine nucleotide exchange factor SEC2", "aln": "MDASEEAKRVSIQVTSLSTQLIESVDKQSHLEEQLNKSLKTIASQKAAIENYNQLKEDYNTLKRELSDRDDEVKRLREDIAKENELRTKAEEEADKLNKEVEDLTASLFDEANNMVADARKEKYAIEILNKRLTEQLREKDTLLDTLTLQLKNLKKVMHSLDNESTVTNNSNRYSTILSDSATSSSTSLNKVPTSYSLASQDIYSGIVYSPSISSIRYDISLYNEFLKFVAALPRCENIKATSTESKLIRRLVNDEIQPILKIDNASGIGWLVKKTLLSLIIDGLVVVEPLSGVNATYQIGYNSSSPAKQATSNMPKMFKFPLDSPPVAVHAACSFCGESRDDIIEHARMYILKTLHKTDDGKEQVTNTYPLCHWCLLKLRQTCEIFAFLRSLKVGAWHLEKLTTQNITKEDLEKFSEVTKHTKRDGRVSSQDKKTKRLSFMAGLGINSSTKNKPKMEIFSSETNAKPGQPTTNIQRAWLQLCKLRCILHWTHIGIWAVDDSISSKIGPLVEDDSDEDQNDAISVRLQDKALWKQDAKRPFSSSSAEESQKSDAFDFESGDMENEITGESSSDESSSDGSSTDNSTADSSSEDESSLADSTTSSADSSSPESIDNGEGDDTVTKDDKSSIKSANNNEENSDCGDKKGRSIIKKKAPQRKIQKKKLLQDLDDLEEQFREESAIDQTEFENAESNVKQNISSKRASSGDENSKKDNNEKTLKTNLTIGDKTQEQIGENSPSSGLHASSSNDDNFDDAQEQQ", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. :. : : ::: . .: :. . . : : .: . : ::.. *:. :. : : : . . :.* *.* :.. * * . : **: . :.. .*: : :: * .::*:. * . : *:. . *:.*. .. ... :: * . : *:. .: * :.* *. : *:*.: : * : **::.. :.. :. :.* : : :.*: .*: .:.::.* . .. . ..: :*:.:...*: . : .:: ... **.. :. . * . ::: : : : : ::. :* :* : . : . :. . : ", "identical_positions": 37, "similar_positions": 160, "identity": "4.87%" }, { "cls_id": "homologset.agr.HGNC:16509", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VC66-1", "uniprot_id": "ADIP_MOUSE", "id": "Q8VC66-1", "name": "Afadin- and alpha-actinin-binding protein", "aln": "MGDWMT-VTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSSVPLSKNVHGVFGVFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMNKKDKNIAMDVLNYVGRADGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQKKKPRERAEDGTGTVAISDIEDDSGELSRDSVWGLSCDTVREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGLNEEDVISRQDHEQETEKLELEIERCKEMIKAQQQLLQQQLATTCDDDTTSLLRDCYLLEEKERLKEEWTLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTNFDHQNSENVKLFSAFSGSSDPDNLIVHSRPRQKKLHSVANGVPACTSKLTKSLPASPSTSDFRQTHSCVSEHSSISVLNITPEESKPSEVARESTDQKWSVQSRPSSREGCYSGCSSAFRSAHGDRDDLP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8CGZ2-1", "uniprot_id": "ADIP_RAT", "id": "Q8CGZ2-1", "name": "Afadin- and alpha-actinin-binding protein", "aln": "MGDWMT-VTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSATPLSKNVHGVFSAFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELSIVALLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLEASRREMISLQERDRQLQCKNRNLHQLLKNEKEEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMNKKDKNIAMDVLNYVGRVDGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILLENAELKKVLQQMKKEMISLLSPQKKKPRERAEDSTGTVVISDVEDDAGELSRDGVWSLSCDTVREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGFHEEDVISRQDHEQETEKLELEIERCKEMIKAQQQLLQQQLATACDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTTFDHQNSENVKLFSAFSGSSDPDNLIVHPRPRQKKPHSVANGVPACTSKLAKSLPTSP--SDFCPSRSCVSEHSPVSALTVTPEETKPNEVGRESTDQKWSVVSRPSSREGCYGGCSSAYTSSHVERDDLP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y2D8-1", "uniprot_id": "ADIP_HUMAN", "id": "Q9Y2D8-1", "name": "Afadin- and alpha-actinin-binding protein", "aln": "MGDWMT-VTDPGLSSESKTISQYTSETKMSPSSLYSQQVLCSSIPLSKNVHSFFSAFCTEDNIEQSISYLDQELTTFGFPSLYEESKGKETKRELNIVAVLNCMNELLVLQRKNLLAQENVETQNLKLGSDMDHLQSCYSKLKEQLETSRREMIGLQERDRQLQCKNRNLHQLLKNEKDEVQKLQNIIASRATQYNHDMKRKEREYNKLKERLHQLVMNKKDKKIAMDILNYVGRADGKRGSWRTGKTEARNEDEMYKILLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQKKKPRERVDDSTG-TVISDVEEDAGELSRESMWDLSCETVREQLTNSIRKQWRILKSHVEKLDNQVSKVHLEGFNDEDVISRQDHEQETEKLELEIQQCKEMIKTQQQLLQQQLATAYDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWLKQQFLNMTTFDHQNSENVKLFSAFSGSSDWDNLIVHSRQPQKKPHSVSNGSPVCMSKLTKSLPASPSTSDFCQTRSCISEHSSINVLNITAEEIKPNQVGGECTNQKWSVASRPGSQEGCYSGCSLSYTNSHVEKDDLP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TUL9-1", "uniprot_id": "A0AB32TUL9_DANRE", "id": "A0AB32TUL9-1", "name": "", "aln": "MGDWWSPAMMPDPTLDTKELSS-ISGISMSPSRQNSQHSLHSTMVLPKSTYSVLSAFCTEENISQCVTYINQEVCSLGLSAVSVECKS----GSVSAVPVLNLLYEVLQLQRRAQRGLQELETQQIKNCSDLEHLQNNNCRLKDQLEHTRRENSGLHEGERQLQLKIKTLQNCLKSEKEEVQKLQSIISSRATQYNHDLKRKERDFTKLKDRLNQLLMDKRDKKLSIEVSNYVGRSDGKRGLWKTGKMEARHEGEMYKALLTDYEARQRSLMLENSELKKVLQHMKKDMIAILSPKKPCVKAELADDSLEQAGSECEDEAGESSRE-TLEQSCEQAREKLTNSIRLQWRKLKSHMERLDSQASLVASQEREAEELISRKDQEEELQRMRLELQQCKEFIHMQQQLLQQQISSPCDEETAALLNDCYTLEEKERLKEEWRLFNEQKRNFERERKNFTEAAIRLGHERKVFEEDRAAWLKTQFLNMTPFVDRKR---------PALSEPHSALSVGTEPEAKLHSTP---PLFTKSLTN--------SVFCTPKAAPVKMPTTADLYRTLNLIPESRGHGKCPSAEMLSRSRLRNSS---SDCS-VISLVRDENSSV-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** : . * :.* :*. * .**** **: * *: *.*..:..:..*** :**.*.::*::**: ::*:.:: *.*. .:. *.:** : *:* ***: . :.:***::* **::***. .:**:*** :*** .*:* :**** * :.*:: **.**:******.**:*********:*****::.***:**:**:*:*:**:::::: ***** ***** *:*.* ***:*.**** **.*** **:.:::**:*******:***:**::***:* : . *.: . *: *:::** **: **: .**:****** *** ****:*:**.*.* * : . *::***:*:*:* :::.**:::***:*: ********:::. *::*::**.*** *********** **:***:******:.********* ***.***:**:*:* ****** * .:: .. *: .. : : * **.. * ..*:: * * .::. : .. * * : .. :... : ** . . ..** : :...: ", "identical_positions": 266, "similar_positions": 188, "identity": "43.18%" }, { "cls_id": "homologset.agr.HGNC:16510", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B2RYN2-1", "uniprot_id": "FBX31_RAT", "id": "B2RYN2-1", "name": "F-box only protein 31", "aln": "----MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERIEAG-------------------------------------PARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCR-----------------------------DVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQVRQEQ-----EAGEG-------------PAPHREPAVKDPEGPPAKASKEAGPGAEAAEQSSTSGQGQPFVLPAGVSSRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSRVQATFQNADAPSPQAFDEMLRNIQSLTS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TQF0-1", "uniprot_id": "FBX31_MOUSE", "id": "Q3TQF0-1", "name": "F-box only protein 31", "aln": "----MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERIEAG-------------------------------------PARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCR-----------------------------DVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQVRQEQ-----EAGEG-------------AAPPREPSAKAADGPPAKDGKEPGGGAEAAEQSASSGQGQPFVLPVGVSSRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSRVQATFQNAAAPSPQAFDEMLRNIQSLTS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5XUX0-1", "uniprot_id": "FBX31_HUMAN", "id": "Q5XUX0-1", "name": "F-box only protein 31", "aln": "----MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASA-----------------------GVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCR-----------------------------DVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IYD6-1", "uniprot_id": "A0AC58IYD6_DANRE", "id": "A0AC58IYD6-1", "name": "", "aln": "MLLRMAVCARLCGVGQSRRCRRRQRHSQADQDSDSDMEMEEGEEEERVVGKAKDEPDGSGIGGGCHSSCGAGPSGAGSGASASGSAGPPHPQSLLDLPPELLVEIFASLPGIALPNLALVCKKFRQILNTETIWRRRCTEEFGMRDDLRKMEIVGISSRDLYVKRVNPQVKSGRFMKLLPDYEHMDYRDVYTHLLHPYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWEKNKATVECMYGHKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQEEFRTWLEEEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPCLPSDLLQPGLFKGTYGSHGLEIIMLSFHGSKAKATKLTGDPNVPAGQLTLEIDLQRPVRLPDLEQQRSMEELSRLVLGVHEEVQRAS------QSQG------------VQAEAAESEVEASDSAPPAGAEDEEPAAAAAPKT------QAFVLPLGVMARNEVYPRTCKMCFYGTGLIAGHGFTSPERTPGLFILFDDDRFGFIWLELKSFSLYSRLTDQLTHAQAPSMQRFENMLRNMQSWTS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *********** :* *****:: . : : :* * : . ****: . * ***:*************** **.** **.:**:**:*:******* **:*: ::***:**.*:*.* ***::*** ***************************************:* **** :******: *:: *************:*.** **:***************.***********.******************************************. *.**::***************:****** :*:.**:*****:**** *:****:: ::***:*: *.::****:** *:*.*:: . .:* *. : .:..* . : .. ** :. *.**** ** :*** *****::*********************:*:***:*****:************: : :* *** * *::**:*:** **", "identical_positions": 344, "similar_positions": 93, "identity": "57.82%" }, { "cls_id": "homologset.agr.HGNC:16511", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CHH9-1", "uniprot_id": "SEPT8_MOUSE", "id": "Q8CHH9-1", "name": "Septin-8", "aln": "---MAATDLERVSNAEPEPRSLSLGGHVGFDSLPDQLVSKS--------------------VTQGFSFNILCVGETGIGKSTLMNTLFNTTFET---------EEASHHEECVRLRPQTYDLQESNVHLKLTIVDAVGFGDQINKDDSYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVA----EINAVMNAHLPFAVVGSTEEVKVGNKLVR--ARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQ----------------ETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRIHQEEKR----------------------KVEEKRRELEEETNAFNCRKAAMEALQSQALHATSQQPLRKDKDKKN------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B0BNF1-1", "uniprot_id": "SEPT8_RAT", "id": "B0BNF1-1", "name": "Septin-8", "aln": "---MAATDLERISNAEPEPRSLSLGGHVGFDSLPDQLVSKS--------------------VTQGFSFNILCVGETGIGKSTLMNTFFNTTFET---------EEASHHEECVRLRPQTYDLQESNVHLKLTIVDAVGFGDQINKDDSYRPIVDYIDTQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVA----EINAVMNAHLPFAVVGSTEEVKVGNKLVR--ARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQ----------------ETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRIHQEEKR----------------------KVEEKRRELEEETNAFNCRKAAMEALQSQALHATSQQPLRKDKDKKK---VGGWSSIYSVTIP--------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q92599-1", "uniprot_id": "SEPT8_HUMAN", "id": "Q92599-1", "name": "Septin-8", "aln": "---MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKS--------------------VTQGFSFNILCVGETGIGKSTLMNTLFNTTFET---------EEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVA----EINAVMNAHLPFAVVGSTEEVKVGNKLVR--ARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQ----------------ETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKR----------------------KVEEKRRELEEETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKNRSDIGAHQPGMSLSSSKVMMTKASVEPLNCSSWWPAIQCCSCLVRDATWREGFL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q642H3-1", "uniprot_id": "SEP8A_DANRE", "id": "Q642H3-1", "name": "Septin-8-A", "aln": "---MAATDVDIFSNEE--KRNLSLGGHVGFDSLPDQLVSKS--------------------VTQGFCFNILCVGETGIGKSTLMNTLFNTMFEN---------EEASHYQNGVYLRPRTYDLQESNVHLKLTIVDTVGFGDQINKEESYKPIVDYIDTQFENYLQEELKVKRSLFNYHDTRIHICLYFISPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMSELVSNGVQIYQFPTDDEAVT----EINSSMNAHLPFAVVGSVEEVKVGNKTVR--ARQYPWGVVQVENESHCDFVKLREMLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSQPFSLQ----------------ETYEAKRKEFLGDLQKKEEEMRQMFVNKVKETEAELKEKERELHEKFEQLKRMHQEEKR----------------------KVEEKRRELEEEMNAFNRRKVAAETLSLSQP-------LKKDKDKKN------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A4FUM1-1", "uniprot_id": "SEP8B_DANRE", "id": "A4FUM1-1", "name": "Septin-8-B", "aln": "---MAATEVNTYPTEE--MRSLSLSGHVGFDSLPDQLVSKS--------------------VSQGFSFNILCVGETGIGKSTLMNTLFNTTFEN---------EEASHFHNGVHLRPRTYSLQESNVDLQLTIVDTVGFGDQVNKEESYKPIVDYIDAQFENFLEEELKIKRSLYNYHDSRIHICLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTVSKSELQKFKIKIMSELVSNGVQIYQFPTDDEAVA----EINSSMNAHLPFAVIGSSEEVKIGNKMVR--ARQYPWGVVQVENESHCDFVKLREMLIRVNMLDLREQTHARHYELYRRCKLEEMGFKDTDADSEPFSLQ----------------ETYVAKRREFIVELQMKEEQMRQMFVNKVKETEAELKEKERELHERFEMLKRTHQEEKR----------------------SLEEMRRDFEEEMNTFNRRKVAAETLQSLQGSTG----LKKDKEKKT------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P54359-1", "uniprot_id": "SEPT2_DROME", "id": "P54359-1", "name": "Septin-2", "aln": "----MSVEVDFVDKKEVHLRTLKQSGHVGFDSLPDQLVNKS--------------------VQNGFVFNVMCIGETGLGKSTLMDTLFNTSFES---------TPSPHTLPSVKLKAHTYELQESNVRLKLTICDTVGYGDQINKDDSFKAVVDYIDAQFENYLQEELKIKRSLVTCHDSRIHICLYFICPTGHGLKSLDLVCMKKLDSKVNIIPVIAKADTISKVELQRFKAKIIQELNANGVHIYQFPTDDETVA----ETNTSMNSHIPFAVVGSTEFIKVGNKLIR--ARQYPWGTVQVENETHCDFVKLREMLIRTNMEDMREKTHTRHYELYRQKRLEQMGFSDVDSDNKPISFQ----------------QTFEAKRSNHLAELQSKEEEVRQMFVQRVKEKEAELKESEKDLHAKFEKLKRDHAEEKR----------------------KLEESRKALEEDYLDFQRRKQQLATAHHTLT-------LGKSKKK--------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32458-1", "uniprot_id": "CDC11_YEAST", "id": "P32458-1", "name": "Cell division control protein 11", "aln": "-MSGIIDASSALRKRKHLKRGITFTVMIVGQSGSGRSTFIN----------------------------TLCGQQVVDTSTTILLP-----------------TDTSTEIDLQLREETVELEDDEGVKIQLNIIDTPGFGDSLDNSPSFEIISDYIRHQYDEILLEESRVRRNPR-FKDGRVHCCLYLINPTGHGLKEIDVEFIRQLGSLVNIIPVISKSDSLTRDELKLNKKLIMEDIDRWNLPIYNFPFDEDEISDEDYETNMYLRTLLPFAIIGSNEVYEMGGDVGTIRGRKYPWGILDVEDSSISDFVILRNALLISHLHDLKNYTHEILYERYRTEALSGESVAAESIRPNLTKLN---------------GSSSSSTTTRRNTNPFKQSNNINNDVLNPASDMHGQSTGENNETYMTREEQIRLEE--------------------------ERLKAFEERVQQELLLKRQELLQREKELREIEARLEKEAKIKQEE--------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q07657-1", "uniprot_id": "SHS1_YEAST", "id": "Q07657-1", "name": "Seventh homolog of septin 1", "aln": "MSTASTPPINLFRRKKEHKRGITYTMLLCGPAGTGKTAFANNLLETKIFPHKYQYGKSNASISSNPEVKVIAPTKVVSFNSKNGIPSYVSEFDPMRANLEPGITITSTSLELGGNKDQGKPEMNEDDTVFFNLIMTHGIGENLDDSLCSEEVMSYLEQQFDIVLAEETRIKRNPR-FEDTRVHVALYFIEPTGHGLREVDVELMKSISKYTNVLPIITRADSFTKEELTQFRKNIMFDVERYNVPIYKFEVDPEDDDLESMEENQALASLQPFAIITSDTRDSEGRYV-----REYPWGIISIDDDKISDLKVLKNVLFGSHLQEFKDTTQNLLYENYRSEKLSS-VANAEEIGPNSTKRQSNAPSLSNFASLISTGQFNSSQTLANNLRADTPRNQVSGNFKENEYEDNGEHDSAENEQEMSPVRQLGREIKQENENLIRSIKTESSPKFLNSPDLPERTKLRNISETVPYVLRHERILARQQKLEELEAQSAKELQKRIQELERKAHELKLREKLINQNKLNGSSSSINSLQQSTRSQIKKNDTYTDLASIASGRD-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : * :. : : ..: . . :. :. .:. . :. . :.. : :.: : * *:.::.. . . : .*: *:: * ** :::*. .* *:* .**:* ****.*:.:*: ::.:.. .*::*:*:::*:.:: ** : *: :: .: **:* * : * * : : ***:: * . * *:**** :.:::.. .*: *:: *: :: :::: *: ** ** *. . : . : . : ::: . : : . : :.: . . : . :. .. .: ", "identical_positions": 53, "similar_positions": 134, "identity": "9.48%" }, { "cls_id": "homologset.agr.HGNC:16512", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VIM4-1", "uniprot_id": "BSND_MOUSE", "id": "Q8VIM4-1", "name": "Barttin", "aln": "MADEKTFRIGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPKALSLLETGLS-EVKSP--QPPYVRLWEEAAYDQSLPDFTHIQMKVMGYSEDPRPLLAPEL---KTGASSVREGEPRTAQAWMEAPVVVHRGSDENEGEKSHSQSSPS--VGPQGSAPLASFHDDLDVGSSEGSSLQPSP-NRDEPH--RQVPWASRGPLDRFSDFALIDDTPTSEDTVLDGQAREAALPRKQQWSLRMKGETVQA---RAEEPEQEEEDLYYGLPDSPGNPLPDKELGFEPDIQG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8R2H3-1", "uniprot_id": "BSND_RAT", "id": "Q8R2H3-1", "name": "Barttin", "aln": "MADEKTFRIGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSIMVIGGVLWSMCQCYPKITFVPADSDFQGMLSPKALSLLETGLS-EVKSP--QPPYVRLWEEAAYDQSLPDFTHIQMKVMGYSEDPRPLLAPEL---KTGTSSAKEGEPHSAQTWMEAAVVVHRELDEKEGEKSRSQSSPP--ACSQGSAPLASFHDDLDVGSSEGRSPQPSPPDRDEAH--LQVPWASRGPLDRFGDFALIDDTPISEDMGLEGQAQEEALPSKQPWSLRMKEETVQA---GAEEPEQEEEDLYYGLPDSPGDPLPDKELGFEPDVQG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WZ55-1", "uniprot_id": "BSND_HUMAN", "id": "Q8WZ55-1", "name": "Barttin", "aln": "MADEKTFRIGFIVLGLFLLALGTFLMSHDRPQVYGTFYAMGSVMVIGGIIWSMCQCYPKITFVPADSDFQGILSPKAMGLLENGLAAEMKSPSPQPPYVRLWEEAAYDQSLPDFSHIQMKVMSYSEDHRSLLAPEMGQPKLGTSDGGEGGPGDVQAWMEAAVVIHKGSDESEGERRLTQSWPGPLACPQGPAPLASFQDDLDMDSSEGSSPNASPHDREEACSPQQEPQGCRCPLDRFQDFALID-APTLEDEPQEGQQWEIALPNNWQRYPRTKVEEKEASDTGGEEPEKEEEDLYYGLPDGAGDLLPDKELGFEPDTQG", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F4W6-1", "uniprot_id": "E7F4W6_DANRE", "id": "E7F4W6-1", "name": "", "aln": "MAENKPYRYGLIVLGMAFVALGMFMISVEEPHVFVTFCAMGVIMMGIGTVWTVCQCYPRVTVILQE-------------------------------------------------------------------------------------KEELCGAEKQDLIEGRSDEKSSAKPVK-------------APLAGFCDDDEAEIS--------------------------------ADPKLHTESKRSEHVIVLQTCRSSPSVLTCSSSPQTDRKSSRP------DPNRE---MYYGRVKDSCNVTSELESE-------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::*.:* *:****: :::** *::* :.*:*: ** *** :*: * :*::*****::*.: : * ::. **... : . ****.* ** : * * * : *. . . . : . : .. :*::* :*** ... : .: * ", "identical_positions": 49, "similar_positions": 55, "identity": "15.26%" }, { "cls_id": "homologset.agr.HGNC:16513", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A096MKC4-1", "uniprot_id": "A0A096MKC4_RAT", "id": "A0A096MKC4-1", "name": "Transmembrane channel-like protein", "aln": "----------------------------------MLQIQVEGK-----------------------------------------------------------------------------------EDDTDASSSEEEEE-----DKLPRRESLRPKRKRTRDVINEDDPEPEPEDEE-----------TRKAREKERRRRLRR---------------GAEEEEE-----------IDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGK------GKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKN-IGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKAN------------------------------------------------------------------------------------------------------------------------------------------------------ITLWEANMIKAYNESLS---GNTTGPPFFVHP----------------------------------------------------------------------------------------ADVPRGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKMAAARA-----AAAAGGQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R4P5-1", "uniprot_id": "TMC1_MOUSE", "id": "Q8R4P5-1", "name": "Transmembrane channel-like protein 1", "aln": "----------------------------------MLQIQVEEK-----------------------------------------------------------------------------------EEDTEESSSEEEE------DKLPRRESLRPKRKRTRDVINEDDPEPEPEDEE-----------TRKAREKERRRRLRR---------------GAEEEEE-----------IDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGK------GKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKN-IGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKAN------------------------------------------------------------------------------------------------------------------------------------------------------ITLWEANMIKAYNESLSGLSGNTTGAPFFVHP----------------------------------------------------------------------------------------ADVPRGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKMAAARA-----AAAAGGQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TDI8-1", "uniprot_id": "TMC1_HUMAN", "id": "Q8TDI8-1", "name": "Transmembrane channel-like protein 1", "aln": "------------------------------MSPKKVQIKVEEK-----------------------------------------------------------------------------------EDETEESSSEEEEEVE---DKLPRRESLRPKRKRTRDVINEDDPEPEPEDEE-----------TRKAREKERRRRLKR---------------GAEEEE------------IDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGK------GKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKN-IGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKAN------------------------------------------------------------------------------------------------------------------------------------------------------ITLWEANMIKAYNASFS---ENSTGPPFFVHP----------------------------------------------------------------------------------------ADVPRGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARA-----AAAAGRQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QFU0-1", "uniprot_id": "TMC1_DANRE", "id": "F1QFU0-1", "name": "Transmembrane channel-like protein 1", "aln": "-----------------------MPRHKLIASESDVSIEVDEGKDKESCVYYVEVEENCERGKIKQASRDGKRRRERNGETRRKASEKRTNEGESKKAEKKHEKGHRTARKAGEKHGKRQRRKNAGEEDAEDKSSKEKKNMKNEKNKTLKLEEEKEKDVRKKKRKHVKNEEDETNHEK-----------TKQHLKEEKRRKKRKKPETTSESESKSESESASESESKNSPAVGVLGSLTPEELENLKEAVEERKKLITQLKGKPWPMRRKLVVLRESQEFVEKYEGALGK------GKGRKLYAYKVMMMKKWMKFQRDFENFKTACIPWEMKIKEIESHFGSSVASYFIFLRWMYGINMILFGLTFGLVMVPEALMGKPYGSLPRKTVPREEEASAMNFAVLWDFGGYAKYSVLFYGYYNSQRAIGWLKFRMPLSYFLVGVGTVAYSYMVVIRTMARN-ANEEGGGDDTSFNFSWKTFTSWDYLIGNPETADNKFASITTSFKEAIVEEQESRKDDNIHLTRFLRVLANFLVLCCLAGSGYLIYFVVRRSQKFALEGLENYGWWERNEVNMVMSLLGMFCPMLFDVISTLENYHPRIALQWQLGRIFALFLGNLYTFIIALMDAIQLKRAEEEIVKKN------------------------------------------------------------------------------------------------------------------------------------------------------MTIWQAN---LYNGTVP---DNSTAPPLTVHP----------------------------------------------------------------------------------------ADVPRGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETMVGQEFVRLIISDTMTTYITLLIGDFMRAVLVRFLNNCWCWDLEYGFPSYSEFDVSGNVLGLIFNQGMIWMGAFYAPCLPALNLLRLHVSMYLQCWAVMCCNVPQERVFKASGSNNFYMAMLLVILFLSTLPAIYTIVSIPPSFDCGPFSGKPRMFDVIQETLETDFPAWFSKVFSYASNPGLVLPFLLLLVLAIYYLQSTSKTYKRVNMELKKKLQAQNEENKKKNKLAALKAASDLEQARKAGEQRRNSISDLGVNEENPESHVSSSHT--------------------------SRPPASRGHTSSGHLPGHPQQPQKNSKKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0U1QT59-1", "uniprot_id": "TMC_DROME", "id": "A0A0U1QT59-1", "name": "Transmembrane channel-like protein", "aln": "MQNDEEPAAAAGTSGLSNGESLRSPPAPAPRRPKPGILRLDIGKPRRSSGGSVDFRCVGSSSSNGNTSNVATGANSENNSGVTSPHQLSVTWAPPCDLDRGGWQMQSSADAKREFYKGQRGRRAASQEDHRSYELNDFPLQNQSSDAESCHQEPHFAHQRSPGIGFDEDGGGGDIDDEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVLLVNHSEDLAKHDN----WLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHRNESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKKIFKVPEVKQAEPTATTLTNRWRKVLEASSPVTPTQPPDFDTEEYKNQARKELISRIMKKALRKGSATSDEDSFVRRDDDDTDTEHQDSLPHDEEAKDKRFGLSRLQQIRRTRKPSLVDIVQIAKQERARAGSIVAGTSSSGTGNFPIKETHPKSRFKVEKHERKDRGSMKDKKDTRHRQSPQQQQQPPPYESPKDNEHDPDTNSRIVSASLLRRHKEQAEGEEPPTTPDAPQTPNSPVEPVEQALEESTPETPTLAKSKFHIVDEKKPPPHEVEDKPLPTPKESGSGGGSLGKFKFRKHKFKSNNVAAVKPEPEVFKFDERSVERSSDVPATHAAEYLNNEPSGTEEQDRSLPSPTPSQGQGHHQRQLSVLSRQGRKKIGNLLALVREAVNLKKDDVEQAGSDESPGPTTPTYLAYTPPPPPSVLSSVSSSTALEMPPTPEPESPTPSAPLHFGSSTSSRAPSKPPKPPMVPASATAPTATMDDLEELDTAGPITFPRRSDSHRRRTMRQDSQSSIWSDNIPTITISTTGSDECIVDAAAPQNGLPDPRSASPEPTVNIIRIDIENEHEK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.:: ::: . :: : :. : *. .: .:: :: . * : .... . . *.: : .:::* :* :** :.:*: :::::: :* . **** : .. :*::* :* :: *: .* :. :*** :** ***:***.***** ****: :*::: ..::: ** : : *** :. * * *: .:::* * :** :*****.. *. :::**:***..: **::..:: *:.* ... ...* **** * .**::**:.***.*:: *:. .****: ** : ::. : *.*.*::*: *. ** : *.:*:.:* .. * .:* :*:.*:**.:* * :*: :. :*::** *: *.**: * : *** :::::: *: * :::* : :: *. :. : .:* .* . * :: *:* **** :***: :: : * : : :: * **:** :**: * ****:* :*.* :*.:: *:* ** *** :*** *::* * :*:::* **::.* *: ****. ***** *****:.:** :***..:*. * ** : **:.***** *: :.* :* . :* : : : :... *:..:*:::* **** : : : .* :*:.::: : *:: : . : :. ", "identical_positions": 213, "similar_positions": 268, "identity": "10.44%" }, { "cls_id": "homologset.agr.HGNC:16516", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P57682-1", "uniprot_id": "KLF3_HUMAN", "id": "P57682-1", "name": "Krueppel-like factor 3", "aln": "MLMFDPVP---------VKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSPPIKKYSPPSPGVQP--FGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D4A4V3-1", "uniprot_id": "D4A4V3_RAT", "id": "D4A4V3-1", "name": "", "aln": "MLMFDPVP---------VKQEAMDPVTVSYPSNYIESMKPNKYGVIYSTPLPDKFFQTPEGLAHGIQMEPVDLTVNKRGSPPSAAGSPSSLKFP-SHRRASPGLSMPSSSPPIKKYSPPSPGVQP--FGVPLSMPPVMAAALTRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMDNSNSGMPVPVIESYEKPILQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q60980-1", "uniprot_id": "KLF3_MOUSE", "id": "Q60980-1", "name": "Krueppel-like factor 3", "aln": "MLMFDPVP---------VKQEAMDPVSVSFPSNYIESMKPNKYGVIYSTPLPDKFFQTPEGLTHGIQVEPVDLTVNKRGSPPAAGGSPSSLKFP-SHRRASPGLSMPSSSPPIKKYSPPSPGVQP--FGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMDNSNSGMPVPVIESYEKPLLQKKIKIEPGIEPQRTDYYPEEMSPPLMNPVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2BG67-1", "uniprot_id": "A2BG67_DANRE", "id": "A2BG67-1", "name": "", "aln": "MLTCDPKPDMSLYQPYSTLIKSHETFGMVLPPAVVSGAHLYPSHYHPSYQLPYSHRQSQD--VHQAQIEPVDLSIGNKSS----GSSPSSSLAS-SSPRASP----PS---PYEAHSPASRCSQNRQLSPSLTLPIPAVTQVLTPFVSSPGMIPVIP--MPLSVLYPPSLHLSPSIIISPVTPEDPAN-HKHFSVIKS------ENTSDHHELLKPIKSEPHPEHTQDNHSQEKSVITALPNYNDRGNTQSP-----KVESPDLLKKRRIHRCDFNGCNKVYTKSSHLKAHRRTHTGEKPYKCMWEGCTWKFARSDELTRHYRKHTGVKPFHCPDCDRTFSRSDHLALHKKRHLLV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ** * . :: :.. : *. :.. : * ** .. *: : * *:*****::.::.* ..**** . * **** ** * : :**.* * :. .*::* .: : : ***::*** : .* : : **. .:::* : :. ..**:* ::. . . ::* ::: :**. . : * ** : *. . .* ***** :********::*************************** *****************:*****:***:******:**********:***:**", "identical_positions": 143, "similar_positions": 82, "identity": "40.17%" }, { "cls_id": "homologset.agr.HGNC:16517", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6G6J0-1", "uniprot_id": "A0A8I6G6J0_RAT", "id": "A0A8I6G6J0-1", "name": "Transmembrane protease serine 6", "aln": "MPRCFQLPCSTRMPTAEVPQAAGGQGDGGDGEEAAEPEGVFKAPRNAKRKDRDYVRFTP--LLLVLAALASAGVMLWYFLGYKAEVTISQVYSGSLRVLNRHFSQDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYAFGEGPLICFFWFILDIPEYQRLTLSPEVVRELLVGELLS--NSSALASYRTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQDCQVNLTLEGRLDPQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGFRTLQPYAERIPVVASDGITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVLT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DBI0-1", "uniprot_id": "TMPS6_MOUSE", "id": "Q9DBI0-1", "name": "Transmembrane protease serine 6", "aln": "MPRCFQLPCSTRMPTTEVPQAADGQGDAGDGEEAAEPEGKFKPPKNTKRKNRDYVRFTP--LLLVLAALVSAGVMLWYFLGYKAEVTVSQVYSGSLRVLNRHFSQDLGRRESIAFRSESAKAQKMLQELVASTRLGTYYNSSSVYSFGEGPLTCFFWFILDIPEYQRLTLSPEVVRELLVDELLS--NSSTLASYKTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLPLKGPDQQTTSCLWHLQGPEDLMIKVRLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGMHSYYDPFLLSVKSVAFQDCQVNLTLEGRLDTQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNRLCTQGQWMIQNRRLCGFRTLQPYAERIPMVASDGVTINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQSDCRDGSDEQHCDCGLQGLSSRIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPVSNTLQKVDVQLVPQDLCSEAYRYQVSPRMLCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQVLT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IU80-4", "uniprot_id": "TMPS6_HUMAN", "id": "Q8IU80-4", "name": "Transmembrane protease serine 6", "aln": "---MLLLFHSKRMPVAEAPQVAGGQGDGGDGEE-AEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * *.***.:*.**.*.****.***** ***** **. .::*** *.*:*:.* :**.* .*.****:*********** :******************* **** ***:*:******::**::************:*:****** *******:***::** ******: *** **** ***: ..*::****************:**..*************. **** *:***: ::*********:***:*::**** .:****:****.*********************:******::********:**:****:***:.*.** *:*****:.***.**.* ***:******.******************************: ****** ********:* *********:**: *:***************:*:*.**************************:**************** ***:*********:*** *************************************:***:.********:******** *******::*************:******************************. ********: ****************:************************ **:**************** ********* ***** *.:********:*****.*.*****:**************************: ********************:******:* *:.*****:*", "identical_positions": 663, "similar_positions": 105, "identity": "81.35%" }, { "cls_id": "homologset.agr.HGNC:16519", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U1Y1-1", "uniprot_id": "RAB34_RAT", "id": "Q5U1Y1-1", "name": "Ras-related protein Rab-34", "aln": "------MNILAPVRRDRVLAEL--------PQCLKKEAALHVRKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHSKQWLADALKENDPSNVLLFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWSVSSLTGENVREFFFRVAALTFEANVLAELE--KSGSRHIGDVVRINS---DDKNLYLTASKKKATCCP-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64008-1", "uniprot_id": "RAB34_MOUSE", "id": "Q64008-1", "name": "Ras-related protein Rab-34", "aln": "------MNILAPVRRDRVLAEL--------PQCLKKEAALHVRKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLTDALKENDPSNVLLFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWAVSSLTGENVREFFFRVAALTFEANVLADVE--KSGARHIADVVRINS---DDKNLYLTASKKKATCCP-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZG1-1", "uniprot_id": "RAB34_HUMAN", "id": "Q9BZG1-1", "name": "Ras-related protein Rab-34", "aln": "------MNILAPVRRDRVLAEL--------PQCLRKEAALHGHKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYALMEKDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEANVLAELE--KSGARRIGDVVRINS---DDSNLYLTASKKKPTCCP-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1Q809-1", "uniprot_id": "A0A8M1Q809_DANRE", "id": "A0A8M1Q809-1", "name": "", "aln": "-----MMNSLPPVKGDRIICEL--------PLYFTRDAAVHTKDGFNITVREACQGQKT---GLNVAKVIVVGDVGVGKTCLINRFCKDSFDRTYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFRCIASTYYRGAQAIIVVFDLSNYESLDHAREWLEDAMRDNDPSSVLLFLVGTKKDLSHPDLLAQMEQEAIRLSEEIRAEYWAVSALSGASVRDFFLRVASLTFEATVLSELE--KNNSRRAGDIVKISN---NCDNNFK---KRQSSCCH-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0A7-1", "uniprot_id": "Q9W0A7_DROME", "id": "Q9W0A7-1", "name": "Ras-related protein Rab-36", "aln": "MPHRLRQNLLLPQPPTVVLHDPRTHLRHLPPAYSAAQTPLSKERDFGAQVRYYLEAPRK--PKFRPCKVIFVGDCSVGKTAIVNRFCYDKFQSNYKATIGVDFELENFSILGHNYSLEMWDTAGQERFRCIAGAYYRNASVIVVTYDMSKKDSLESAKKWLNSALNYNASKRPLVFLVGTKADLLSKEEFVRMERLAGLAAAELQAEYWSVSARSGFKVTELFQRIAALAFEEAVMQEIRSIKNKPQEQATQASVKSQTFDLRNFFGSRLSQQKSGCTC", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * * :: : * ::.: . .* * : :. :. .***.*** .****.::**** *.*: .**********:*.*.:** :**::*********:***.:***.*..*::.:::.. **: :::** .*:. * .. *:****:* ** **: * : *::****:**: :* .* ::* *:*:*:** *: ::. *. .:. . . :.. : * : .:: : * ", "identical_positions": 91, "similar_positions": 87, "identity": "32.62%" }, { "cls_id": "homologset.agr.HGNC:16521", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZZP2-1", "uniprot_id": "D3ZZP2_RAT", "id": "D3ZZP2-1", "name": "small monomeric GTPase", "aln": "-MEAIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMHVQPFQIVFLLVGHKCDLASQ---RQVSREEAEKLSKDCGMKYIETSAKDATNVEESFTILARDIYELIKKGDICIQDGWEGVKSGFV-PNTVHSSEEAVKPRKQCFC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BHD0-1", "uniprot_id": "RB39A_MOUSE", "id": "Q8BHD0-1", "name": "Ras-related protein Rab-39A", "aln": "-METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLHSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMHVQPFQIVFLLVGHKCDLASQ---RQVSREEAERLSTDCGMKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFV-PNTVHSSEEAVKPRKECFC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14964-1", "uniprot_id": "RB39A_HUMAN", "id": "Q14964-1", "name": "Ras-related protein Rab-39A", "aln": "-METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMYVQPFRIVFLLVGHKCDLASQ---RQVTREEAEKLSADCGMKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVKSGFV-PNTVHSSEEAVKPRKECFC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W3Q0-1", "uniprot_id": "Q9W3Q0_DROME", "id": "Q9W3Q0-1", "name": "", "aln": "MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELS----DPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPNSLDFNLVVAEPEKSSCC", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*.*: ******:*********.**: **:*:*. * *********:**:*:: *.:******************:******** :**:**:*: ****: *: **: :::*.: ** *** * ** . *:*: ***:::: : *::::****:..:****:* ::::::* *:.*: :***:*:**** **::. . ..:*.*.. *", "identical_positions": 115, "similar_positions": 67, "identity": "51.8%" }, { "cls_id": "homologset.agr.HGNC:16522", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6P7A1-1", "uniprot_id": "LARG2_RAT", "id": "Q6P7A1-1", "name": "Xylosyl- and glucuronyltransferase LARGE2", "aln": "MLP--RGRPR----ALG-AALLLLLLLVVG-------FFLFG-------RDP--------------------EYGLGTTATLDGDP----YGSRNRSTSS--------------------LQLLLPPKCEMLHVAIVCAGYNSSREIITLMKSVLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSVLPLSLARVIVLDTDVTFSSDIMELWALFGHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQIGWEQMWKLTAKRELLTLTATSLADQDIFNAVIKEHPELVHPLPCVWNVQLSDHTLAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRDLHLTFLGFDGKLLCRELFGCPNQFPPGVEQLQQALAQLDEEEPCFEFRQQQLTVHRVHITFLSHQPPPPRP-HDVTLVAQLSMDRLQMLEALCRHWRGPMSLALYLTDAEAQQFLRFVETSPVLSARKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLALGRRQRKAALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHASTDYTRWREAQAPYRVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRDCLQALKEEFHQDLSRRYGSAALKYLTALQQSRSRA--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5XPT3-1", "uniprot_id": "LARG2_MOUSE", "id": "Q5XPT3-1", "name": "Xylosyl- and glucuronyltransferase LARGE2", "aln": "MLP--RGRPR----AMGAAVLLLLLLLVVG-------FFLFG-------RDP--------------------DYGLGTTATLDEDP----YRSRNLSASS--------------------PQLLLPPKCEMLHVAIVCAGYNSSREIITLTKSLLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSILPPSLARVIVLDTDVTFSSDIVELWALFDHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNAVIKEHPHLVHPLPCVWNVQLSDHTRAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRNLHLTFLGYDGKLLRRELFGCPNQFPPGAEQLQQALTQLDEEEPCFEFRQQQLTVHRVHITFLPHQPPPPQP-HDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDEEAQQFLHFVETSPVLSMRKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLELDSR-RKTALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHSSTDYSRWREAQAPYSVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRNCLQALKEEFHQDLSRRYGSAALKYLTALQQARSRA--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N3Y3-1", "uniprot_id": "LARG2_HUMAN", "id": "Q8N3Y3-1", "name": "Xylosyl- and glucuronyltransferase LARGE2", "aln": "MLP--RGRPR----ALG-AAALLLLLLLLG-------FLLFGGDLGCERREPGGRAGAPGCFPGPLMPRVPPDGRLRRAAALDGDPGAG-PGDHNRSDCG--------------------PQPPPPPKCELLHVAIVCAGHNSSRDVITLVKSMLFYRKNPLHLHLVTDAVARNILETLFHTWMVPAVRVSFYHADQLKPQVSWIPNKHYSGLYGLMKLVLPSALPAELARVIVLDTDVTFASDISELWALFAHFSDTQAIGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLRLDRLRQAGWEQMWRLTARRELLSLPATSLADQDIFNAVIKEHPGLVQRLPCVWNVQLSDHTLAERCYSEASDLKVIHWNSPKKLRVKNKHVEFFRNFYLTFLEYDGNLLRRELFVCPSQPPPGAEQLQQALAQLDEEDPCFEFRQQQLTVHRVHVTFLPHEPPPPRP-HDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDAEAQQFLHFVEASPVLAARQDVAYHVVYREGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLGLGSR-RKAALVVPAFETLRYRFSFPHSKVELLALLDAGTLYTFRYHEWPRGHAPTDYARWREAQAPYRVQWAANYEPYVVVPRDCPRYDPRFVGFGWNKVAHIVELDAQEYELLVLPEAFTIHLPHAPSLDISRFRSSPTYRDCLQALKDEFHQDLSRHHGAAALKYLPALQQPQSPARG", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q66PG1-1", "uniprot_id": "LARG2_DANRE", "id": "Q66PG1-1", "name": "Xylosyl- and glucuronyltransferase LARGE2s", "aln": "MLCPCRGKLKLLVVSLSFVILFTWLYLLVGNSENGRSLLLSACLVESTEARLLERDVLASRVREVEEENRQIRLQLSQSQGLAGQPAEGNYGNQQWVASADTGPEDVENTAEERANHSECSRSPTAEKCELLHVACVCAGHNASRDVVTLVKSILFHRRNPLHFHFITDTVANQILSTLFQSWMVPSVQVSFYDADELKSEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAIFRKFTEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLYLERLRRMGWEQMWRLTAERELMSMLSTSLADQDIFNAFIKQNPVLVHQLPCFWNVQLSDHTRSEQCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSQASSESTVLQQALEELDEDDQCYDFRRERIMLHRVHLYFLQYEYSPTDDGTDITLVAQLSMDRLQMLEAICKHWEGPISLALYMSDAEAQQFLRYAQASEVLKNRKNVGYHIVYKEGQFYPVNLVRNVALRNVNTPYVFLTDVDFLPMYGLYDYLRKSIVQLDMANT--KKALVVPAFETLRYRLSFPKSKAELLSMLDMGTLYTFRYHVWTKGHAPTNYAKWRTATTPYKVEWEADFEPYVVVRRDCPEYDQRFVGFGWNKVSHIMELDAQEYDLIVLPNAFMIHMPHAPSFDISKFRSSPSYRYCLTTLKDEFHQDLSRKYGSAALKYLTAQRNI------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** **: : ::. . : * *::* ::* . * : * :* .:: .. : . ***:**** ****:*:**:::** **:**:*:****:*::**:**.:**.***::****:* ****.*::**. ***********:******.*.. ** .*::*******:**::** ****:* :*::.*.:******************:**************** *:**:: ******::**.***::: :***********.**::* **: ***.********* :*:** *.:*******************.****:::**** :**:** **** **.* .. ***** :***:: *::**:::: :****: ** :: .*. *:****************:*:** **:*****::* ******::.::* ** *::*.**:**::* :**** :***** :. ******:*:**** *.****** ** ** : * **********:**:***:**.***::** *:*:***** *.:**:.*:*::** * :** *:* *::****** ****.** **********:**:*******:::***:** **:*****:***:*****:** ** :**:********::*:******.* :: ", "identical_positions": 424, "similar_positions": 168, "identity": "55.94%" }, { "cls_id": "homologset.agr.HGNC:16523", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P35292-1", "uniprot_id": "RAB17_MOUSE", "id": "P35292-1", "name": "Ras-related protein Rab-17", "aln": "MAQAAGLPQAS----------TASGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLP-TVGCAFFTKVLDLG--------SSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEE--------------------REVTFQEGKEFAESKSLLFMETSAKLNYQVSEIFNTVAQELLQRAGDTGSS--------RPQEGEAVALNQEPPIRQRQ-CCAR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B2RZ46-1", "uniprot_id": "B2RZ46_RAT", "id": "B2RZ46-1", "name": "Ras-related protein Rab-17", "aln": "MAQAGGLPQAS----------PSSGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLP-TVGCAFFTKVVDLG--------SSSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFHPGEVVVMLVGNKTDLGEE--------------------REVTFQEGKEFAESKSLLFMESSAKLNYQVSEIFNTIAQELLQRAGDGQSS--------SPQEGEAVVLNQGPTVRPRQ-CCA-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H0T7-1", "uniprot_id": "RAB17_HUMAN", "id": "Q9H0T7-1", "name": "Ras-related protein Rab-17", "aln": "MAQAHRTPQPR----------AAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILP-TVGCAFFTKVVDVG--------ATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQE--------------------REVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRS-DEEGQ--------ALRGDAAVALNKGP-ARQAK-CCAH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P36018-1", "uniprot_id": "YPT52_YEAST", "id": "P36018-1", "name": "GTP-binding protein YPT52", "aln": "--------------------------MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQSITIHPNDGNETKDVVIKFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSLQKARNWVDELKNKVGDDDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAISTEEAKQYAQEQGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKQNRQIGGGNNGQVDINLQRPSTNDPTS-CCS-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9V3I2-1", "uniprot_id": "RAB5_DROME", "id": "Q9V3I2-1", "name": "Ras-related protein Rab5", "aln": "MATTPRSGGASGTGTAQRPNGTSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIE--------DTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPN-IVIALAGNKADLS--------------------NIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLP--KND-----------GANNQGTSIRPTGTETNRPTNNCCK-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ******..:***:*:. *::* * . *:*.**::: : : :*:*********:*:*:. :*:*.*:**::**** .:**: :*: *:.:*.:: . ::: * ***.** * : :*.*::*:.: *** * *** . *.::* :.::* * . : . ** ", "identical_positions": 66, "similar_positions": 63, "identity": "25.19%" }, { "cls_id": "homologset.agr.HGNC:16524", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P61106-1", "uniprot_id": "RAB14_HUMAN", "id": "P61106-1", "name": "Ras-related protein Rab-14", "aln": "------------------------MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q91V41-1", "uniprot_id": "RAB14_MOUSE", "id": "Q91V41-1", "name": "Ras-related protein Rab-14", "aln": "------------------------MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LXD4-1", "uniprot_id": "A0ABK0LXD4_RAT", "id": "A0ABK0LXD4-1", "name": "Ras-related protein Rab-14", "aln": "------------------------MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M1PEV5-1", "uniprot_id": "A0A8M1PEV5_DANRE", "id": "A0A8M1PEV5-1", "name": "Ras-related protein Rab-14", "aln": "------------------------MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIMEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSETQPQREGCGC", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q86BK8-1", "uniprot_id": "Q86BK8_DROME", "id": "Q86BK8-1", "name": "Ras-related protein Rab-14", "aln": "MSKVRSVVNKLHERIDYFIEKCPNMTAAPYNYNYIFKYIIIGDMGVGKSCLLHQFTEKKFMANCPHTIGVEFGTRIIEVDDKKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDTRNLTNPSTVIFLIGNKSDLESTREVTYEEAKEFADENGLMFLEASAMTGQNVEEAFLETARKIYQNIQEGRLDLNASESGVQHRPSQPSRTSLSSEATGAKDQCSC", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::*****.*****************************:*************:**..:**************************************************:******.***:*****:***: *:*******:**:****:****** **:***:****:*:*******:* *****:******:** *. *:**. :: *.*", "identical_positions": 174, "similar_positions": 30, "identity": "72.8%" }, { "cls_id": "homologset.agr.HGNC:16525", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P35279-1", "uniprot_id": "RAB6A_MOUSE", "id": "P35279-1", "name": "Ras-related protein Rab-6A", "aln": "MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSD-VIIMLVGNKTDLADKRQVSIEEGERKAKELN-VMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSRE-DMIDIKLE-KPQEQPVN------EGGCSC----------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9WVB1-1", "uniprot_id": "RAB6A_RAT", "id": "Q9WVB1-1", "name": "Ras-related protein Rab-6A", "aln": "MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSD-VIIMLVGNKTDLADKRQVSIEEGERKAKELN-VMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSRE-DMIDIKLE-KPQEQPVN------EGGCSC----------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H0N0-1", "uniprot_id": "RAB6C_HUMAN", "id": "Q9H0N0-1", "name": "Ras-related protein Rab-6C", "aln": "MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSD-VIITLVGNRTDLADKRQVSVEEGERKAKGLN-VTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSRE-DMSDIKLE-KPQEQTVS------EGGCSCYSPMSSSTLPQKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "O18334-1", "uniprot_id": "RAB6_DROME", "id": "O18334-1", "name": "Ras-related protein Rab6", "aln": "MSSG-DFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNTNSFHQTSKWIDDVRTERGSD-VIIMLVGNKTDLSDKRQVSTEEGERKAKELN-VMFIETSAKAGYNVKQLFRRVAAALPGMDSTENKPSE-DMQEVVLKDSPNETKDP------EGGCAC----------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q99260-1", "uniprot_id": "YPT6_YEAST", "id": "Q99260-1", "name": "GTP-binding protein YPT6", "aln": "MSRS---GKSLTKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGIDFLSKTMYLDDKTIRLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSFEYIDKWIEDVKNERGDENVILCIVGNKSDLSDERQISTEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSLPEFQNSESTPLDSENANSANQNKPGVIDISTAEEQEQSACQC----------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** . *:.* *:*:******.*.******** **:**: *** ************:* *: *:*********:***** ***** .*::*****: :**. ***:**:.***.: **: :***::**:*:**:* ****:*** *. *:** :******* **:::* :** ::.::. . : : : : .* :..* * ", "identical_positions": 115, "similar_positions": 54, "identity": "43.56%" }, { "cls_id": "homologset.agr.HGNC:16526", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8JZR0-1", "uniprot_id": "ACSL5_MOUSE", "id": "Q8JZR0-1", "name": "Long-chain-fatty-acid--CoA ligase 5", "aln": "-------MLFIFNFLFSPLP---------------TPALICLLTFGTAIFLWLINRPQPVLPLIDLDNQSVGIEGGARRGAF-----QKNNDLILYYFSDAKTLYENFQRGLAVSDNGPCLGYRK-------PNQPYKWISYKQVSDRAEYLGSCLLHKGYK------SSQDQFVGIFAQNRPEWVISELACYTYSMVAVPLYDTLGTEAIIFVINRADIPVVICDTPQKATMLVENVEKGLTPGLKTIILMDPFDDDLMKR--------GEKCGVEMLSLHDAENIGKENFKKPVPPKPEDLSVICFTSGTTGDPKGAMLTHENVVSNMAAFLKFLEPIFQPTSDDVT-ISYLPLAHMFERLVQGILFSCGGKIGFFQG-DIRLLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTP-LKKFLLNLAIISKFNEVKNG-----IIRRDSLWDKLVFSKIQGSLGG-KVRLMITGAAPISTPVLTFFRAAMGCWVFEAYGQTECTGGCSITSPGDWTAGHVGTPVACNFVKLEDVADMNYFSVNNE-GEICIKGNNVFKGYLKDPEKTQEVLDKDGWLHTGDIGRWLPNGTLKIVDRKKNIFKLAQGEYIAPEKIENVYSRSR-PVLQVFVHGESLRSFLIGVVVPDPDSLPSFAAKIG-------VKGSFEELCKNQCVKEAILEDLQKIGKEGGLKSFEQVKSIFVHPEPFTIENGLLTPTLKAKRVELAKFFQTQIKSLYESIEE------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O88813-1", "uniprot_id": "ACSL5_RAT", "id": "O88813-1", "name": "Long-chain-fatty-acid--CoA ligase 5", "aln": "-------MLFIFNFLFSPLP---------------TPALICLLTFGTAIFLWLINRPQPVLPLIDLDNQSVGIEGGARRGAF-----QKNNDLILYYFSDAKTLYEVFQRGLAVSDNGPCLGYRK-------PNQPYKWISYKQVSDRAEYLGSCLLHKGYK------PSQDQFIGIFAQNRPEWVISELACYTYSMVAVPLYDTLGAEAIIYVINRADISVVICDTPQKATMLIENVEKDLTPGLKTVILMDPFDDDLMKR--------GEKCGIEMLSLHDAENLGKENFKKPMPPNPEDLSVICFTSGTTGDPKGAMLTHQNIVSNMAAFLKFLEPIFQPTPEDVT-ISYLPLAHMFERLVQGVIFSCGGKIGFFQG-DIRLLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTP-LKKFLLNLAIISKFNEVRNG-----IIRRNSLWDKLVFSKIQSSLGG-KVRLMITGAAPISTPVLTFFRAAMGCWVFEAYGQTECTAGCSITSPGDWTAGHVGTPVSCNFVKLEDVADMNYFSVNNE-GEICIKGNNVFKGYLKDPEKTQEVLDKDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENVYSRSR-PILQVFVHGESLRSFLIGVVVPDPESLPSFAAKIG-------VKGSFEELCQNQCVKKAILEDLQKVGKEGGLKSFEQVKSIFVHPEPFSIENGLLTPTLKAKRVELAKFFQTQIKSLYESIEE------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ULC5-1", "uniprot_id": "ACSL5_HUMAN", "id": "Q9ULC5-1", "name": "Long-chain-fatty-acid--CoA ligase 5", "aln": "-------MLFIFNFLFSPLP---------------TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVS-----QKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRK-------PNQPYRWLSYKQVSDRAEYLGSCLLHKGYK------SSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQR--------GEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVA-ISYLPLAHMFERIVQAVVYSCGARVGFFQG-DIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTP-LKKFLLKLAVSSKFKELQKG-----IIRHDSFWDKLIFAKIQDSLGG-RVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNE-GEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQ-PVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLG-------VKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQD------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1RAK0-1", "uniprot_id": "F1RAK0_DANRE", "id": "F1RAK0-1", "name": "Long-chain-fatty-acid--CoA ligase", "aln": "-------MEFLFEFLFTPLS---------------TSGLVFLFSLAAVALVHLNTRPKPLQPPTDLNRQTVGVAGGARKSAL-----LKSDNLISYMYEDGKTLYEVFQRGLRVSGNGPCLGFRK-------KGQPYQWLKYKQVSDRAEFLGSGLIHRGQK------PSQDTFIGIFAQNRPEWIIAELACYTYSMVAVPLYDTLGPEALVFIINRANISTVICDKKDKAETLLDNSEKKLTPLLKTIILMDSYDSALTER--------GSKIGLDVLSLKDVEALGKNNHHRPVPPKPEDLSIICFTSGTTGDPKGAMLTHENVVADAAGVVRTFESVFVPVPSDVS-ISFLPLAHMFERVVQTVLYGVGGRVGFFQG-DIRLLPDDMKALQPTVFPVVPRLLNRVYDKVQSGAKTP-FKKWLLNFAIEKKCAEVKQG-----IIRNDSMWDKLIFHKVQESLGG-RVRVMVTGAAPISPSVLTFLRACLGCQIFEAYGQTECTAACSFTIPGDWKTGHVGAPIPCNTIKLVDVEEMDYFASNGE-GEICVKGTNVFRGYLGDPEKTAEALDKDGWLHTGDIGKWLPSGVLKIIDRKKNIFKLAQGEYIAPEKIENVYIRSA-PVAQVFVHGESLQSSLVAIVVPDPEVLPGFAEKLG-------LKGSLEELCRNQELKKAIISDLNKLGREAGLKSFEQVKDLYLHPDMFTIENGLLTPTLKAKRADLTKYFRVQIESLYANM--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VVT8-1", "uniprot_id": "Q9VVT8_DROME", "id": "Q9VVT8-1", "name": "Long-chain-fatty-acid--CoA ligase", "aln": "MTPEKSVMAYVNHLIVSNFSYFWDEIDGYLYYLGGTLGTLTLGSLAASVAYYFATRPVPERPLVPLENQSPLLEGPEQIHVSKFYKESKNGKFVSYITENVRTLYQTFREGAYASNNGPCLGWRET------LTSPYQWINYDEALLRAKNFGAGMLALGAR------PKQ--LIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFIIRQTDMQVVIVEDDGKAAMLLEKAPR----SLKIIVAIKPIRQTTLER--------ARSRGIQIFSFIDVEKLGAKGNHPEVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSVILQMG-DHRIRAGDVM-VSFLPLAHMFERCCENGMYYVGGCVGFYSG-DIKELTNDLKMLKPTVMPAVPRLLNRVYDKIQNDISASGLKRGLFNMAMRAKEKEIARG-----VLRRNGCWDKLVFKKVHQAFGG-NLRLMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDVPEMEYFANQNT-GEVCVRGSNVFHGYYKDPEKTAEAIDSEGWHHTGDVGMWLPNGTLRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQ-YVNQVYVYGESLKSCIIAVVVPDTDVLKQWATENN-------VRGTLSVLCNNKNVKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRPQLKSYFKPQLEDMYKHLD-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39518-1", "uniprot_id": "LCF2_YEAST", "id": "P39518-1", "name": "Long-chain-fatty-acid--CoA ligase 2", "aln": "----MAAPDYALTDLIESDPRFESLKTRLAGYTKGSDEYIEELYSQLPLTSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSS-----LSSENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCT--DGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. . : : :. :.. .. .: .: :* *: * . : *** * ..::: .*. . *.. :*: :: .:.* ::*.***:: : .* ::*:. ..**:***.:: .::. :: :* * * : : :. . . : .:*: :.* :* :**..:.* :.:****** ***. ::* *:.:. . . . :: :.:*****:*** * :** * * :*:* *:* .. ***:*.*. ::. . . .:: : : : * .. : . :.:::: *:: ::* . .::.*:**:: .: *:*..:. : :.** ** .. :: : . * . :* .* :* *.: :. **: ::* :**. * :*::* :.:*.:** ***:. .* : ::** *::***::****.******:* * : *::*.*:.*:: ::.:* * : . .. * .*: ::: ::..: : **: **::: : : : :::::.::***:* ** . .:*: :..:* ", "identical_positions": 134, "similar_positions": 241, "identity": "17.75%" }, { "cls_id": "homologset.agr.HGNC:16527", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3U8-1", "uniprot_id": "D4A3U8_RAT", "id": "D4A3U8-1", "name": "Transmembrane channel-like protein", "aln": "--------------MSPQLKSLDGED----------------DKSARRPTRKQTSIAACPQDGHRAQSSRKDPAKGSPRPGSSRKKQMEHGS-----------YQKGLRGQKPCKVERPSQG-RKK-DRRTPLTE------------------------------------------------------RRTPPRKEREVLRKETG-KHLRK----------PRTTSLASSVSTRESLSEEELAQILEQVEEKKKLITTMRNKPWPMAKKLRELREAQAFVEKYEGALGK------GKGKHLYAYRMMMAKKWAKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKESIVDEQESSKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQN--VSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVH--------LKLSNEE-------------------------------------------------------------------------------------------------------------------------------------------------------KIKNITHWTLFNYYNSSGGN----ESVPRPPPHPADVPRGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETAVGIEFMRLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANPGLIIPAILLMF-LAIYYLNSVSKSLSRANTQLRKKIQALREVE----------KNHKSIKGKATVTYSEDTNKNSSKNATQPHLTNEEPTSYSP--SQIQTLDKKARGSSTSRTDGGASQSTS------------------------------------------WHHVGSQP---PRVRQDSGQPQSQTYTGRS-----------------------------PSGKRTQRPHN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R4P4-1", "uniprot_id": "TMC2_MOUSE", "id": "Q8R4P4-1", "name": "Transmembrane channel-like protein 2", "aln": "--------------MSPQLKSLDEEG----------------DKSARRPTRKQTSRAACPQDGHRAQSSRKDPAKGSPRPGSSRKKQMEHGS-----------YHKGLQGQKPRKVERSLQG-RKK-DRRTSLKE------------------------------------------------------QRASPKKEREALRKEAG-KQLRK----------PRSTSLGSSVSTGDSLSEEELAQILEQVEEKKKLITTVRNKPWPMAKKLRELREAQAFVEKYEGALGK------GKGKHLYAYRMMMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKESIVDEQESNKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQN--VSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVH--------LKLSNEE-------------------------------------------------------------------------------------------------------------------------------------------------------KIKNITHWTLFNYYNSSGGN----ESVPRPPPHPADVPRGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETAVGIEFMRLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANPGLIIPAILLMF-LAIYYLNSVSKSLSRANAQLRKKIQALREVE----------KNHKSIKGKAIVTYSEDTIKNSSKNATQIHLTKEEPTSHSS--SQIQTLDKKAQGPHTSSTEGGASPSTS------------------------------------------WHHVGSQP---PRGRRDSGQPQSQTYTGRS-----------------------------PSGKRTQRPHN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TDI7-1", "uniprot_id": "TMC2_HUMAN", "id": "Q8TDI7-1", "name": "Transmembrane channel-like protein 2", "aln": "--------------MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRR-----------HREELGEQERGEAERTCEG-RRKRDERASFQE------------------------------------------------------RTAAPKREKEIPRREEKSKRQKK----------PRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGK------GKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQN--VSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVH--------LKLANEE-------------------------------------------------------------------------------------------------------------------------------------------------------TIKNITHWTLFNYYNSSGWN----ESVPRPPLHPADVPRGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMF-LAIYYLNSVSKSLSRANAQLRKKIQVLREVE----------KSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSA--SQSQAMDKKAQGPGTSNSASRTTLPAS------------------------------------------GHLPISRP---PGIGPDSGHAPSQTHPWRS-----------------------------ASGKSAQRPPH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QZE9-1", "uniprot_id": "TMC2B_DANRE", "id": "F1QZE9-1", "name": "Transmembrane channel-like protein 2-B", "aln": "-----------MCVLQLGWKWMQNLIVEVMWTQK---------EEQK----------AGINQNLRREEGKPNQQTVWRRAKKRRMNRR---------------ARGEAGGRSK-KMRMR--------VRKNRREE------------------------------------------------------ERKLSIPGREQQRKTSQ-RRRSP----------SSCSSSSDNNSDDESMSEGEMARLKEEVEEKKKLIATLRNKPWRMKRRLKCLKEAQEFVEKFEGALGK------GKGRRLYAFKVMMTKKLIKFNRDFENFKTACIPWESRIKEVESHFGSSVASYFIFLRWMYGLNLVLFGFMFGLVVIPELLMGIPYGSIPRKTVPREEQDSAMDFSVLFEFGGYCKYSILFYGFYNNQRTIGFLQFRLPLSYLLVGVGIFGYSLMVVIRTMARNANEGGDGGDEGNFTFCWKLFTSWDYLIGNPETADNKFASTTTSFKESIVDEQENLKDENIHLRRFLRLLANVLILCCLAGSGYLIYAVVKRSQDFAKRDRNELTWLQKNEVEIVMSLLGLVCPPLFEAIAELEDYHPRIALKWQLGRIFALFLGNLYTFLFALFDEVN--------GKLENEK-------------------------------------------------------------------------------------------------------------------------------------------------------QIKNQTVWALKEYYANYTLQYNITENIPPPNIAPADVIRGP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETEVGIEFVKLTVSDIQVTYLTILIGDFLRALIVRFLNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGAFYAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKASRSNNFYMGLLLLVLFLSLMPVIYSIMTLPPSFDCGPFSGKDKMYDVITETIDKDLPPFMADIFSYASNPGLIISVVLLMVWLAIYYLNAVSKAYQNSNLELKRKMQMQRDEE----------KNRRNNK-DSTNQVMKDLEDLLPNKSLIPP-PSVEETEKPA--EQPSKSSKVTGKPGAAASGKGVHVQKD------------------------------------------VSLAAANP--RAPVTRAPGPRQPGPLPGNPRGPPP----------------------GQGMGRGRGGPPPRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7FFT2-1", "uniprot_id": "TMC2A_DANRE", "id": "E7FFT2-1", "name": "Transmembrane channel-like protein 2-A", "aln": "-----------MPKKSDTTRKLEDVGIEIDGDVDS-------AEEDKKSKGKGGKKAAGGKRGKASEDGEDEDEDDKPPKGRRAANKKKPAPVDEEDSDDDIPQRRSAGNRRRGNVRERGDGDKKKSGKKGRRGG------------------------------------------------------KKNEKGKGKDSDKDSDKDEKKKK----------NSSGDESDSDEEDESMSEGEMAKLMEEVEEKKKLIANIRNKPWRMRRRLKVLKEAQQFVDKFEGALGK------GKGRKLYAYKVMMMKKWIKFKRDFENFRTACIPWERKIKEVESHFGSSVASYFIFLRWMYGMNLVLFSLTFGLVVIPEVLMGLPYGSIPRKTVPREDQDTAMDYSVLTDFNGYCKYSVLFYGYYNNQRTIGFLKFRLPLSYLMVGIGTFGYSLMVVIRTMAKNADVGGGDGEDNEFTFAWKMFTSWDYLIGNAETADNKYASITTSFKESIVDEQENQKDENIHLRRFLRVLANFLITCTLGGSGYLIYFVVKRSQEFQNMDN--LSWYEKNELEIIMSLLGLVGPMLFETIAELEEYHPRIALKWQLGRIFALFLGNLYTFLLALFDEVN--------AKLEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------SIKNASIWFLKEYYANYTANNPNDTGTPPP-INPADAIRGP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWETTVGVEFVKLTISDIQVTYLTILIGDFLRAFIVRFLNYCWCWDLEAGWPSYGEFDISGNVLGLVFNQGMIWMGAFYAPGLVGINVLRLLSSMYYQCWAVMACNVPHERVFKASKSNNFYMGLLLLILFLSLLPVVYTIMSLPPSFDCGPFSGKERMFDVVMETIDLDLPAFMGTLFGYVANPGLVISAVLLMV-LAIYYLNSVSEAYKNSNNELKKKMQMARDEE----------KNRRNNK-DSTNQVMKDLEDLLPNRPPTPPSPRENIAEKNQ--GQGGKSAKV--KPGTAG---GVHLQKD------------------------------------------VSLASANPNARGPVTRAPGPRGPGPLPGQP-----------------------------GAGRGQGPPPRRQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0U1QT59-1", "uniprot_id": "TMC_DROME", "id": "A0A0U1QT59-1", "name": "Transmembrane channel-like protein", "aln": "MQNDEEPAAAAGTSGLSNGESLRSPPAPAPRRPKPGILRLDIGKPRRSSGGSVDFRCVGSSSSNGNTSNVATGANSENNSGVTSPHQLSVTWAPPCDLDRGGWQMQSSADAKREFYKGQRGRRAASQEDHRSYELNDFPLQNQSSDAESCHQEPHFAHQRSPGIGFDEDGGGGDIDDEESYTISVSAIMQRRASVRGYRGKRGSRSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDPEARVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQRILVNILVMGLLGLSGATVVLLVNHSEDLAKHDN----WLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHRNESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLI-LIIYYLVSLTGALREANQDLRTQLQKEREEERKKIFKVPEVKQAEPTATTLTNRWRKVLEASSPVTPTQPPDFDTEEYKNQARKELISRIMKKALRKGSATSDEDSFVRRDDDDTDTEHQDSLPHDEEAKDKRFGLSRLQQIRRTRKPSLVDIVQIAKQERARAGSIVAGTSSSGTGNFPIKETHPKSRFKVEKHERKDRGSMKDKKDTRHRQSPQQQQQPPPYESPKDNEHDPDTNSRIVSASLLRRHKEQAEGEEPPTTPDAPQTPNSPVEPVEQALEESTPETPTLAKSKFHIVDEKKPPPHEVEDKPLPTPKESGSGGGSLGKFKFRKHKFKSNNVAAVKPEPEVFKFDERSVERSSDVPATHAAEYLNNEPSGTEEQDRSLPSPTPSQGQGHHQRQLSVLSRQGRKKIGNLLALVREAVNLKKDDVEQAGSDESPGPTTPTYLAYTPPPPPSVLSSVSSSTALEMPPTPEPESPTPSAPLHFGSSTSSRAPSKPPKPPMVPASATAPTATMDDLEELDTAGPITFPRRSDSHRRRTMRQDSQSSIWSDNIPTITISTTGSDECIVDAAAPQNGLPDPRSASPEPTVNIIRIDIENEHEK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . : . :: . : . : .: . . . : .* :: *::. :*::* .:: :** : ::* :::*: :* :.**** : .. ::::* : :::*: .* * **** :**::******.***** ****: :*::: ..:*: ** : : *** :. : * : .: :* ** *** :***:*.. *. ::**::*::..: : **:: .:*.** *: . ..... .*.:*:**.**::**:.***.*: .* ...***::::* *. *: . : *:*.*.*: * ** : :*::*::: : :. * .:* ::: *:**.:. * :**::. :*::*** *: **.**: * : ***::::::: .:: ** :* .. : * : * . . . **** :* *: :: : * :: :: * ***** :**::* ****:* :*.*.:*.*: *:* *: *** :*** *::**** **:::*: **::.* *::.***** *****:*****:.*** :***.::** *::: * **:.***** ::: :.: :* :* : : : :... :*. :**:. * **** ::: : .:* :*: ::* *: * *. . : . . : * :: . . .. . . . : * ", "identical_positions": 216, "similar_positions": 270, "identity": "10.58%" }, { "cls_id": "homologset.agr.HGNC:16528", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QZL9-1", "uniprot_id": "DKKL1_MOUSE", "id": "Q9QZL9-1", "name": "Dickkopf-like protein 1", "aln": "----------MCRLRVLLLLLPLAFVSSSALPIHDVDSQQNTSGFLGLQRLLQSFSRLFLKNDLLRDLDNFFSSPMDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVLISEKVEASIEPER-NPEGDWKVPKVEAKEPPVPVQKVTDSLHPEPR-QVAFWIMKMPRRRTQPDVQDGGRWLIEKRHRMQAIRDGLRGGAREDSLEDGVHIPQHAKLPVRKTHFLYILRPSQQL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0L829-1", "uniprot_id": "A0ABK0L829_RAT", "id": "A0ABK0L829-1", "name": "", "aln": "----------MGRLGVLLLLLPLAFVCASAVPIHDADSQQNSSGFLGLQSLLQSFSRLFLKNDLLQDLDNFFSSPMDFRDLPRNFHQEQNQEHRMGNHTLSSHLQIDKMTDNQTGEVLISEKVVASIEPEV-NPEGDWKVPKVEAKEALVPVQKATDSLHPEPR-RVAFWIMKMPRRRTQPDVQDGNRWLTEKRHRMQAIPAAIRWGP---------------CIPACPTPYPNTIWK----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UK85-1", "uniprot_id": "DKKL1_HUMAN", "id": "Q9UK85-1", "name": "Dickkopf-like protein 1", "aln": "MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSRQL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* ******. .: ::* ****.*:*:.: *: *** ***.*******.:**:.:*.:**:*****.** *:*:*:****::**:**********:***:********:* ***:* . *** ***::* **. **:**.***:*.* : :*****:*:****:: *. :*.:** *****:*** .:* *. :. * : ", "identical_positions": 118, "similar_positions": 57, "identity": "48.76%" }, { "cls_id": "homologset.agr.HGNC:1653", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P31042-1", "uniprot_id": "CD28_RAT", "id": "P31042-1", "name": "T-cell-specific surface glycoprotein CD28", "aln": "MTLRLLFLALSFFSVQVTENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLDVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSP---KLFWPLVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P31041-1", "uniprot_id": "CD28_MOUSE", "id": "P31041-1", "name": "T-cell-specific surface glycoprotein CD28", "aln": "MTLRLLFLALNFFSVQVTENKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSP---KLFWALVVVAGVLFCYGLLVTVALCVIWTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P10747-1", "uniprot_id": "CD28_HUMAN", "id": "P10747-1", "name": "T-cell-specific surface glycoprotein CD28", "aln": "-MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ****: * *:*** *********:**. .* *.***:*****:::******:**::* ***** **:: * *. .:. *****.:.**:*** * ** **:*********.**********:*******:* **** : * * ** ****.*** **.*****:: ::*..*:*.***:********** * *** ******.*******.", "identical_positions": 145, "similar_positions": 41, "identity": "65.61%" }, { "cls_id": "homologset.agr.HGNC:1656", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B4F786-1", "uniprot_id": "B4F786_RAT", "id": "B4F786-1", "name": "CD2 antigen cytoplasmic tail-binding protein 2", "aln": "MPKRKVTFQGVGDEDDEDEISVPKKKLVDPVAGAGGPGSRFKGKHSLDSDEE-DDDE-GSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNQDSQIRDSWLDNIDWVRIKER------------PPDKQQVSDSEEEGSLGQTPMSVQALLEGLLELLLPRETVAGALRRLGARGGGKG-NSKGTGRPN-----SPQRLDRLSGLADQMVAR-GNLGVYQETRERLAMRLKGLGCRTQGSHDPTPPPSLDMFAEEVTEGELETPTPTHREEADSAGDGLMDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CWK3-1", "uniprot_id": "CD2B2_MOUSE", "id": "Q9CWK3-1", "name": "CD2 antigen cytoplasmic tail-binding protein 2", "aln": "MPKRKVTFQGVGDEDGEDEISVPKKKLVDPVAAAGGPGSRFKGKHSLDSDEE-DDDEEGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNQDAQIRDSWLDNIDWVRIKER------------PPDKHQVSDSEEEDSLGQTPMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGSNSKGTGRPN-----SPQRLDRLSGLADQMVAR-GNLGVYQETRERLAMRLKGLGCRAQGSHDPTPPPSLDMFAEEVAEGELETPTPTQREEAESAGDGLMDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFELYT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95400-1", "uniprot_id": "CD2B2_HUMAN", "id": "O95400-1", "name": "CD2 antigen cytoplasmic tail-binding protein 2", "aln": "MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRER------------PPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKG--RKGPGQPS-----SPQRLDRLSGLADQMVAR-GNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VKV5-1", "uniprot_id": "CD2B2_DROME", "id": "Q9VKV5-1", "name": "CD2 antigen cytoplasmic tail-binding protein 2 homolog", "aln": "-------------------MASKRKHQASQKVKE----ESFK-KHTLDSDEE----DSDDYEREYLNDSDIEGGEEGVAKVEDDVKVTPFNMKEELEEGHFDKDGHYHWNKETEAKDNWLDNIDWVKIGTQKNAFD-------PAKDEENSSDEEKNEPVGKAFNLSMNLMKMVEFMKPGETVKMTLQRLGKQRPVLTTLQRIKQKKAGIVDPKTQEISQLTELANEILSKTGNMDIYQDTYESIKAKIADL----PGTSKPKVADDIDMYADDFETKELER-SKTSSSDSSKPTTTTSEVTWEFKWSQD-ETDIQGPFSTEKMLKWSQENYFKNGVYVRKCG-ENTNFYTSNRIDFDLYL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38852-1", "uniprot_id": "LIN1_YEAST", "id": "P38852-1", "name": "Protein LIN1", "aln": "------------MKYTQYPNSSKLKRNSDRREHDEKLSDELHNQSTIYEDEE-----LSRAEYDSDSDSSVEDSTDNENSGKEMDEKSYEKNEDHVEDHRKRKKSKIQLLDIAEFKKENLADLDYQIGNSESKVEKGVNIEPFNIDDEIKHGVFDKDGNYIKTENATENDQQDNEEWMNDVINTEEVNRLEKEQSVKTQNSRHYMVHEALN-LLKFFLVDENETVLESLGRLNKLRKIAISKKNKSLKYVIHGIELLSDLINILEKKGFSEVYEYNRLKVQDAIEEEIFDDSSRIVNHKTKLWGFKWLNK-LDEYHGLYTNYEMSYWQKS-YFKNSVIVKFHSEPDRDENWIHVSCLSFM-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: . . :: : :: .*** . : : ...:*. : . : : ::.:*: : ..: :: :.. * ::*: . .. . ::. .. . * :.** . : : . . : :.: .:: : : : . . . : ::: : .. * :** : : * ::. :* * .. ** :.* : . . : : :.: ", "identical_positions": 20, "similar_positions": 94, "identity": "5.54%" }, { "cls_id": "homologset.agr.HGNC:1659", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LTZ3-1", "uniprot_id": "F1LTZ3_RAT", "id": "F1LTZ3-1", "name": "", "aln": "--------MLWIVLLLLLCTDSLVQDLEFQL------------VAPKSVTVEEALCVHVPCSVSYPSIRPTFG-PVTGYWLLKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDCSLLIRDAQKNDTGVYFFRVVREPFVRYSYRANQLLLHVTPLSRTPDIIIPETLRAGHPSNLSCSVPWACEQGTPPTFSWMSDALTSLS---------SRTTNSSVLTLTPRPQDHGTKLTCLVTFSGAGVTVERTIRLNVTW----------------KSDQMRQVVLVAVG-EAAVKLLILGLCLTLLSVVICRRKATKLSVHMNCENPYQG-----------SPAGLQGAQP-C---------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q63994-1", "uniprot_id": "CD33_MOUSE", "id": "Q63994-1", "name": "Myeloid cell surface antigen CD33", "aln": "--------MLWPLPLFLLCAGSLAQDLEFQL------------VAPESVTVEEGLCVHVPCSVFYPSIKLTLG-PVTGSWLRKGVSLHEDSPVATSDPRQLVQKATQGRFQLLGDPQKHDCSLFIRDAQKNDTGMYFFRVVREPFVRYSYKKSQLSLHVTSLSRTPDIIIPGTLEAGYPSNLTCSVPWACEQGTPPTFSWMSTALTSLS---------SRTTDSSVLTFTPQPQDHGTKLTCLVTFSGAGVTVERTIQLNVTR----------------KSGQMRELVLVAVG-EATVKLLILGLCLVFLIVMFCRRKTTKLSVHMGCENPIKRQEAITSYNHCLSPTASDAVTPGCSIHRLISRTPRCTAILRIQDPYRRTHLRNRAVSTLRFPWISWEGSLRSTQRSKCTKLCSPVKNLCPLWLPVDNSCIPLIPEWVMLLCVSLTLS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P20138-1", "uniprot_id": "CD33_HUMAN", "id": "P20138-1", "name": "Myeloid cell surface antigen CD33", "aln": "--------MPLLLLLPLLWAGALAMDPNFWL------------QVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERG-STKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLG---------PRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTG-----------SASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKD---------TSTEYSEVRTQ------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZAH6-1", "uniprot_id": "D3ZAH6_RAT", "id": "D3ZAH6-1", "name": "", "aln": "--------MLLSRLLPLLWVFKWASGVCFLLPGMFRDINQSLKLELNSVTVQEGLCVLVPCKFIVN-PRNMLSDLVFGYWYHEEKNTQLDSLVATNNPYQLVR-GTQSRFHLSGDLRFNDCSLDIRDAQKSDSGSYFFSLKKE-GMTWNFCEEKISVHVTDLTHTPSISIPQTLELGHPTDVICSVPWACERGTPPIFSWMSAAPISLG---------PTTTFSSVLTLTPRLQDHGTYLTCQVTFPGVGVTVQKTVQINVTYTAQNSTSHVSGRASPGKTEHLAEVVQVAMG-EAAIKFLLLGICFFFLSMRPHEKRVERPATHVDHSATVMD--------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M2BAZ7-1", "uniprot_id": "A0A8M2BAZ7_DANRE", "id": "A0A8M2BAZ7-1", "name": "", "aln": "MKFPAVQREKWLVLLTFLHMWIGSSNGCLYPGGD----YEFKLKLDKNVIPALAGCAQIPCAYSAPMRTHSGR----LVWFSG----SPDFPISPRDME-----RKDGLLRPLAS-ILEECSIVLWDFSGHERVEEYGVMLEWGTNETHVYDERVAVSYSAAKLNISLHS-EVLEAGKRTIIICSLPDLCLN-SDPIVTWKGLNSKQLRRLRFPREMETYLMYSEQLFYTPVPEDHQAEITCEATFG-KNLSASATMTLTVHSHPQILN-----SSTCSLKQDLLTCVCVSQGVPLPDVHWPLQNNIDFNTVVSSDGHITVRSTFTMKVVDLTS------------------ISSPVCVSRNPLGQTNMTLPLNMDEVLEEPEGDGQSKNDLES--------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :* . : :.* . *. :** * * ::. . .:. :: .. .:**: : * : : : . :: : : . .: .*. * . : **:. * . : * .:* . .* . *. * ** :** : :** ..* .::.. *: :.* * : * * : : : : :. ", "identical_positions": 33, "similar_positions": 68, "identity": "7.33%" }, { "cls_id": "homologset.agr.HGNC:166", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QXQ0-1", "uniprot_id": "ACTN4_RAT", "id": "Q9QXQ0-1", "name": "Alpha-actinin-4", "aln": "MVDYHAANQAYQYGPSSGG-NGTGGGGGMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQ----------------------GDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P57780-1", "uniprot_id": "ACTN4_MOUSE", "id": "P57780-1", "name": "Alpha-actinin-4", "aln": "MVDYHAANQAYQYGPNSGGGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQ----------------------GDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43707-1", "uniprot_id": "ACTN4_HUMAN", "id": "O43707-1", "name": "Alpha-actinin-4", "aln": "MVDYHAANQSYQYGPSSAG-NGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQ----------------------GEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9QL95-1", "uniprot_id": "A0A8M9QL95_DANRE", "id": "A0A8M9QL95-1", "name": "", "aln": "MVDYHAVNNQGQYS-----------AGGPPTYMEQENDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIDYDKLRKDDPVTNLNNAFEVAERYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKA----------------------ETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLENRAPEKTMAEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINGAWHKLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEGWTDGKEAMLTQKDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICEQWDALGSLTQNRRESLERTEKQLESIDELYLEYAKRAAPFNNWMEGAMEDLQDMFIVHNIDEIQGLITAHEQFKSTLPEANKEREAIQAIQAEVQKIANYNGIKLAGNNPYTTITPQSIDKKWEKVQQLVPQRDQALQEELTRQQSNDHLRRQFANQANMIGPWIQNKMEEIGRISIEMNGTLEDQLTHLSQYEQSIIEYKPNIDQLEGDHQLIQEALIFDNKYTAYTMEHLRVGWEQLLTTIARTINEIENQVLTRDAKGISQEQLHEYRTSFNHFDKDHSGLLQSEEFKACLISLGYDVENDKQKRTGIMDSDDFRALLISTGNSLGDAEFARIMGIVDPNNSGAVTFQAFIDFMSRETTDTDTADQVIASFKILAGDKNYITAEELRRELPPDQAEYCIARMAPYSGPDAVAGALDYMSFSTALYGESDL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P18091-3", "uniprot_id": "ACTN_DROME", "id": "P18091-3", "name": "Alpha-actinin, sarcomeric", "aln": "MMMENGLSMEYGDG-----------------YMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQ----------------------GDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: :. . . ** **::*:*: **********:**************** *:**:****:************** ****:*****.*** **************:************* *********************** :*************************:*:****** ********:**:* ** **:*: ***.**:***:*****:***.:*::**.:***:*******.:****.***:. *********** ******:***:**:************:***:.* .:::: :*:***::* *** ****:*::*.:** ****************::*:**: ****...*: ** ***.:***** * *****:***:**::** ** ** *** ** :*:. ..*.::*** :*************************** *:*:*. .**:***:**:*** **:**: ** :*:.:*: ** ** *:**:**********::.: *** ******.::**:*** **:***:** :*::* : * : *.: *.: : * . .****::*.: : **..*:****:**::* :* :**.*: ******.:**::****: :*: : *.: ::*:***** :*.:**::: ***.:: ** ** :**::**:*::* **** :*********:* *.***:***:****:*******::*:*:*******:: * * .****:**:****.: :*:* *: :* **:.:****::* * *:**:***:**:******:*** **::**.** :* .:*************** **.**.**:...***** *********:**", "identical_positions": 588, "similar_positions": 207, "identity": "61.51%" }, { "cls_id": "homologset.agr.HGNC:16608", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V8L1-1", "uniprot_id": "G3V8L1_RAT", "id": "G3V8L1-1", "name": "Apoptosis-associated speck-like protein containing a CARD", "aln": "-MGRARDAILDALENLTADEFKKFKMKLLTAPVREGYGRIPRGALLQM-DPIDLTDKLVSYYLEGYGLELTMTVLRDMGIQELAEQLQKIMEE-------SGAVATATSVPAQGTARTE-HFVDQHRQALIARVTEVDGLLDALYG-NVLTEGQYQAVRAETTNQNKMRKLFS-FAPAWNLTCKNLFLEALRQTQPYLVTDLEQS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EPB4-1", "uniprot_id": "ASC_MOUSE", "id": "Q9EPB4-1", "name": "Apoptosis-associated speck-like protein containing a CARD", "aln": "-MGRARDAILDALENLSGDELKKFKMKLLTVQLREGYGRIPRGALLQM-DAIDLTDKLVSYYLESYGLELTMTVLRDMGLQELAEQLQTTKEE-------SGAVAAAASVPAQSTARTG-HFVDQHRQALIARVTEVDGVLDALHG-SVLTEGQYQAVRAETTSQDKMRKLFS-FVPSWNLTCKDSLLQALKEIHPYLVMDLEQS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9ULZ3-1", "uniprot_id": "ASC_HUMAN", "id": "Q9ULZ3-1", "name": "Apoptosis-associated speck-like protein containing a CARD", "aln": "-MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSM-DALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQG------SGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYG-KVLTDEQYQAVRAEPTNPSKMRKLFS-FTPAWNWTCKDLLLQALRESQSYLVEDLERS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9I9N6-1", "uniprot_id": "ASC_DANRE", "id": "Q9I9N6-1", "name": "Apoptosis-associated speck-like protein containing a CARD", "aln": "MAESFKEHLQEAFEDLGADNLRKFKSKLGDRRQEP---RVTKSAIEKLKDEIDLADLMVGVFTSKDAVSVTVEILRAIKCNAVADDLLRNTGQSESKGALSDESKCASSKAVSKVAFSKVNFIDEHWKELIDRVNNVDPILDILRQKKVITNEDYCTIRNKETPQKKMRELLTGPITCAGNKGKEVLYDALRESNKFLMDDLEDAE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: : :*:*:* .::::*** ** . *:.:.*: .: * :**:* :*. : . . .:* :** : : :* :* : *. . . . . .* . :*:*:* ** **.:*: :** * .*:*: :* ::* : * .***:*:: .. . . *: : :**:: : :*: *** : ", "identical_positions": 49, "similar_positions": 72, "identity": "23.79%" }, { "cls_id": "homologset.agr.HGNC:16609", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V660-1", "uniprot_id": "G3V660_RAT", "id": "G3V660-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-----------MGLYATAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLR------PHLAKVLVYELLLGK--GFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQE--RPGQAHQVPRFVRVNTLKTCPEDAIDYFKRQGFSYQGR------ASSLEDLRTLKGQHFLLDPLLPELLVFPAQTD--LHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLK------NQGKIFAFDQDAKRLAAMATLLARAGVSCCEVAEKDFLTVSPSDQRYGQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKE-----------------------RLQALAGFQQRALCHAL-RFPSLQRLVYSTCSLCQEENEDVVQEALQ---QNSGTFRLAP---VLPTWPHRGLSTFPGS-EHCLRASPETTLTGGFFIAVFERAEVVPSPAPQTSAVVPE-PLSKAPKRKRRR----------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4F6-1", "uniprot_id": "NSUN5_MOUSE", "id": "Q8K4F6-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-----------MGLYAAAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLR------PHLAKVLVYELLLGK--GFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLQESSRPGQAYQVPRFVRVNTLKTRPEDAIDYFKRQGFSYQGR------ASSLEDLRALKGQHFLLDPLLPELLVFPAQTD--LHEHPLYRAGHLILQDKASCLPAMLLSPPPGSHVIDACAAPGNKTSYIAALLK------NQGKIFAFDQDAKRLAAMATLVARAGVSCCELAEKDFLTVSPSDQRYSQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKE-----------------------RLQALAGFQQRALCHAL-RFPSLQRLVYSTCSLCQEENEDVVQEALQ---HNSGTFRLAP---VLPTWPHRGLSTFPGS-EHCLRASPETTLTGGFFIAVFERAEVVPTPAPQTDAMDPE-PLSQVPKRKRRRK------------AAVGASMQPST----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63ZY6-1", "uniprot_id": "NSN5C_HUMAN", "id": "Q63ZY6-1", "name": "Putative methyltransferase NSUN5C", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPELLVFPAQTD--LHEHPLYRAGHLILQDRASCLPAMLLDPRQAPMSWMPVPPQAIKTSHLAALLK------NQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRYREVHYVLLDPSCSGSGMPSRQLEEPGAGTPSPV-----------------------RLHALAGFQQRALCHAL-TFPSLQRLVYSMCSLCQEENEDMVQDALQ---QNPGAFRLAP---ALPARPHRGLSTFPGA-EHCLRASPKTTLSGGFFVAVIERVEMP-TSASQAKASAPERTPSPAPKRKKRAKSCSRCLHTALHIAEAPGSLLPGGKGRCLSSPWKTLGPHRRQQFAF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3BD27-1", "uniprot_id": "A0A8M3BD27_DANRE", "id": "A0A8M3BD27-1", "name": "", "aln": "-----------MALYLKAAEILEKVEQKRGAVKTLVYDSKFPNIKQLFALVCETQKYSSVLQEIINSTKLLK-ETKLR------IHLAKVLVYDLLIGH--GVKCGG-AWKTTMLKHRARLQAALARIKIKRKVSRNQDLLPSSIQQTQNDVIPRYVRVNTLKTSLEDVIDYLKREGFSYQGT------PGRLEDLDRLSGKMFLCDLHLKDLLVFSGKTD--FHDHFLYKAGHIILQGKASCLPAFLLNPPVGSHVIDACAAPGNKTSHLAAIMK------NKGKLFAFDLDAKRLSTMSTLLLRAGVTCHKLANQDFLKVDPQNSEYKEVKYILLDPSCSGSGMVCLRDELP--ETQEDG-----------------------RLQALAAFQLHCLNHAL-QFPQLERIVYSTCSIHSQENEEVVTACLQ---RNPG-FRLVH---LLPDWPERGHEPLT----QCLRASTAKTRTHGFFVAMLERRPAQ-SDKETPPLNTPLSSASQEKQDKPQSNPSDEEQENMETSNEQPANPSSKKKRK------RNRKKHKKQES--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VDZ4-1", "uniprot_id": "NSUN5_DROME", "id": "Q9VDZ4-1", "name": "28S rRNA (cytosine-C(5))-methyltransferase", "aln": "-MSKKPHSIKVPTQYRATAKILKAALEQQKCIKTLIFAEKHARTRSLHTVLKKFSENRVALEKAIEETGLLRDNPSFD------PSLAKILVTELLFGR--KELNGESKPVQTVRSYKDRLLNSIRDFGVQRKEPN-----------------PRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFMTDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQ------NKGCIYSVEQDHVRYNTLCEITKDAGCDIVKPILGDALNLTP--ERFPDVEYILVDPSCSGSGMQNRMTVCD--EPKEDK-----------------------RLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQ---LNPSFKLLSCKKALRNKWHNVGDKDYPNIGKNVLYCQPDSDLTDGIFLALFEKRREGEKD---------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53972-1", "uniprot_id": "RCM1_YEAST", "id": "P53972-1", "name": "25S rRNA (cytosine(2278)-C(5))-methyltransferase", "aln": "MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLS-EDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTLK--------VDKWSELVPGSIYYDEFIPNLFGIHPSDK--ITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAM-SFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD--------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : . . * * : ::*:*.:*:*:.* :* * . .. . ** : . : *: :::.: * * : : ** . : . .: :* .::********: ** * .:* : : **: ** :::.*. **: :*** :* * . : . * . : * : *: : ", "identical_positions": 44, "similar_positions": 62, "identity": "7.8%" }, { "cls_id": "homologset.agr.HGNC:16611", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "J3QP15-1", "uniprot_id": "J3QP15_MOUSE", "id": "J3QP15-1", "name": "", "aln": "MSCQQSQQQCQPPP----KCTPKCPSKCQAPKCPPKCSPKCPPVSSCCSLGSGGCCSSSSGGCCSS----SSGGCCSSGGGGCCLSHHRPRRSLRRHRHSSGCCS--SGGSSGCCGSSG---GSSG-CCGSS---------------QQSGDCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3YUU5-1", "uniprot_id": "D3YUU5_MOUSE", "id": "D3YUU5-1", "name": "", "aln": "MSCQQSQQQCQAPA----KCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCCGSSSGCCCSSGGCCSSGGCCSSGGGGCCLSHHRHHRSLHRHRHSSGCCS--SGGSSGCCGSSG---GSSG-CCGSSGGSSG-----CCGSSQQSGGCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LAT7-1", "uniprot_id": "A0ABK0LAT7_RAT", "id": "A0ABK0LAT7-1", "name": "", "aln": "MSCQQNQQQCQPPPKCPPKCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCCS--SGGCCGS----SSGGCCSSGGGGCCLSHHRPRRSFRRHRHSSGCCS--SGGSSGCCGSSGGCCGSSGGCCGSSGGSSGGCCGSSCGGNQQSGDCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5T7P3-1", "uniprot_id": "LCE1B_HUMAN", "id": "Q5T7P3-1", "name": "Late cornified envelope protein 1B", "aln": "MSCQQNQQQCQPPP----KCIPKCPPKCLTPRCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGS----SSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSG----------------------------QHSGGCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.*****.*. ** *** . .*:*****.***********:.*****. ** .*.* ******************* :** :: :****** ***** * *.** *:**.**", "identical_positions": 83, "similar_positions": 19, "identity": "53.9%" }, { "cls_id": "homologset.agr.HGNC:16612", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5Y4Y7-1", "uniprot_id": "A0A8I5Y4Y7_RAT", "id": "A0A8I5Y4Y7-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCCLSHHRR-RSHRCRRRSSSSCDRGSGQQSGGSGCGHTSGGCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0KYI1-1", "uniprot_id": "A0ABK0KYI1_RAT", "id": "A0ABK0KYI1-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCCLSPHRR-RSHRCRRRSSSSCDRGSGQQSGGSGCGHTSGGCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F8VQJ0-1", "uniprot_id": "F8VQJ0_MOUSE", "id": "F8VQJ0-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTTQCLPAASSCCATSSGGCSLPSSEGGCCLSHHRR-RSHRCRRRSSSSCDRGSGQQSGGSGCSHSSGGCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "E9Q8V1-1", "uniprot_id": "E9Q8V1_MOUSE", "id": "E9Q8V1-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTTQCLPAASSCCATNSGGCSVPSSEGGCCLSHHRR-RSHRCRRRSSSSCDRGSGQQSGGSGCGHSSGGCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q91V05-1", "uniprot_id": "Q91V05_MOUSE", "id": "Q91V05-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSLPSSEGGCCLSHHRR-RSHRCRRRSSSSCDRGSGQQSGGSGCGHSSGGCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LXW1-1", "uniprot_id": "A0ABK0LXW1_RAT", "id": "A0ABK0LXW1-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCCLSHHRH-RSHRCRRRSSSSCDRGSGQQSGGSGCGHTSGGCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5T5A8-1", "uniprot_id": "LCE3C_HUMAN", "id": "Q5T5A8-1", "name": "Late cornified envelope protein 3C", "aln": "MSCQQNQQQCQPPPSCPSP----KCPPKSPAQCLPPPSSDCALSSGGCG-PSSESGCCLSHHRHFRSHQCRRQRSNSCDRGSGQQGGGSCRGHGSGGCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.*:******.**** ******.:****..** ** .****. ****.***** **: ***:***: *.*********.*** .* *****", "identical_positions": 70, "similar_positions": 16, "identity": "70.71%" }, { "cls_id": "homologset.agr.HGNC:16614", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZQC0-1", "uniprot_id": "D3ZQC0_RAT", "id": "D3ZQC0-1", "name": "", "aln": "MSCQQNQQQCQPPPKCTPKCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCCGSSSGGCCGSSSGGCCSSGGGGCCLSHHRPRRSFHRHRHSSGCCSSGGSSGCCGSS---------------------------GGCCGSSGG---------------------CCGSSCGG-------------SQQSGDCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I5YC63-1", "uniprot_id": "A0A8I5YC63_RAT", "id": "A0A8I5YC63-1", "name": "", "aln": "MSCQQNQQQCQPPPKCTPKCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCCGSSSGGCCGSSSGGCCSSGGGGCCLSHHRPRRSFHRHRHSSGCCSSGGSSGCCGSS---------------------------GGCCGSSGGSSG------------------CCGSSCGG-------------SQQSGDCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I6AQR9-1", "uniprot_id": "A0A8I6AQR9_RAT", "id": "A0A8I6AQR9-1", "name": "", "aln": "MSCQQNQQQCQPP----PKCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCCGSSSGGCCGSSSGGCCSSGGGGCCLSHHRPRRSLRRHRHSSGCCSSGGSS---------------------------------GGCCGSSG----------------------CCGS-----------------SQQSGDCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0LAT7-1", "uniprot_id": "A0ABK0LAT7_RAT", "id": "A0ABK0LAT7-1", "name": "", "aln": "MSCQQNQQQCQPPPKCPPKCPPKCQTPKCPPKCPPKCPPKCPPVSSCCSLGSGGCC--SSGGCCGSSSGGCCSSGGGGCCLSHHRPRRSFRRHRHSSGCCSSGGSSGCCGSS---------------------------GGCCGSSGGCCGSS----------GGSSGGCCGSSCGG-------------NQQSGDCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5TCM9-1", "uniprot_id": "LCE5A_HUMAN", "id": "Q5TCM9-1", "name": "Late cornified envelope protein 5A", "aln": "MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQCSAP-----------CPPPVSSCCGSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGG-----------------------------SSCCHSSGGSG-------------------CCHS--------------------SGGCC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZG26-1", "uniprot_id": "D3ZG26_RAT", "id": "D3ZG26-1", "name": "", "aln": "MSCQQSQQQCQPP--------PKCKIPKCPPSS---------------------CCSLGSGGCCGSSSGGCCSSGGGSCCLSHHKPRFSLRRRRHSSGCCSSGGSSCCGSSGGSSGGSSCCGSSGGSSSGSSCCGSSGGSSCCGSSGGSSGGSSCCGSSGGSSGGSSSGCCGSSGGSSGGSSSHQQSGGSSCCSGGCC", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.******* *** *****.. * ..************ **.******:** *::*: :**.**.**... ..** *** ** * **.**", "identical_positions": 63, "similar_positions": 19, "identity": "31.82%" }, { "cls_id": "homologset.agr.HGNC:16615", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LXW1-1", "uniprot_id": "A0ABK0LXW1_RAT", "id": "A0ABK0LXW1-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCCLSHHRHRSHRCRRRSSSSCDRGSGQQSGGSGCGHTSGGCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0KYI1-1", "uniprot_id": "A0ABK0KYI1_RAT", "id": "A0ABK0KYI1-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSVPSSEGGCCLSPHRRRSHRCRRRSSSSCDRGSGQQSGGSGCGHTSGGCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91V05-1", "uniprot_id": "Q91V05_MOUSE", "id": "Q91V05-1", "name": "", "aln": "MSCQQSQKQCQPPPKCPSPKCSPKCPPKSTAQCLPAASSCCATSSGGCSLPSSEGGCCLSHHRRRSHRCRRRSSSSCDRGSGQQSGGSGCGHSSGGCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYE3-1", "uniprot_id": "LCE3D_HUMAN", "id": "Q9BYE3-1", "name": "Late cornified envelope protein 3D", "aln": "MSCQQNQQQCQPPPKCPSP----KCPPKSPVQCLPPASSGCAPSSGGCG-PSSEGGCFLNHHR-RHHRCRRQRPNSCDRGSGQQGGGSGCGHGSGGCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.*:*********** ******..****.*** **.*****. ******* *. ** * *****: ..*********.******* *****", "identical_positions": 74, "similar_positions": 12, "identity": "75.51%" }, { "cls_id": "homologset.agr.HGNC:16617", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35779-1", "uniprot_id": "BHE41_RAT", "id": "O35779-1", "name": "Class E basic helix-loop-helix protein 41", "aln": "MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLT--TLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVS-HLHAVAT------QLLTPQVTPGRGPGRAPCSAGAAAASGSER-------VARCVPVIQRTQPGTEP--EHDTDTDSGYGGEAEQ------------GRAAVKQEPPGDPSAAPKRLKLEARG----------------ALLGPEP-----------ALLGSLVALGGG--APFAQP--AAAPFCLPFYLLSP-SAAAYVQPWLDKSGLDKYLYP-AAAAPFPLLYPGIPA--------AAAAAAAAAFPCLSSVLSPPPEKAGSAAGAPFLAHEVAPPGSLRPQHAHSRTHLPHA-----VNPES-SQEDATQPAKDAP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PV5-1", "uniprot_id": "BHE41_MOUSE", "id": "Q99PV5-1", "name": "Class E basic helix-loop-helix protein 41", "aln": "MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLT--TLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVS-HLHAVAT------QLLTPQVPSGRGSGRAPCSAGAAAASGPER-------VARCVPVIQRTQPGTEP--EHDTDTDSGYGGEAEQ------------GRAAVKQEPPGDSSPAPKRPKLEARG----------------ALLGPEP-----------ALLGSLVALGGG--APFAQP--AAAPFCLPFYLLSP-SAAAYVQPWLDKSGLDKYLYP-AAAAPFPLLYPGIPA--------AAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRA-----VNPES-SQEDATQPAKDAP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9C0J9-1", "uniprot_id": "BHE41_HUMAN", "id": "Q9C0J9-1", "name": "Class E basic helix-loop-helix protein 41", "aln": "MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLT--TLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLIN-HLHAVATQFLPTPQLLTQQVPLSKGTG-APSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSPPPEKAGAAA-ATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKEAP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q01068-1", "uniprot_id": "ESM3_DROME", "id": "Q01068-1", "name": "Enhancer of split m3 protein", "aln": "-------------------MVMEMSKTYQYR--------------KVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGLSLQGVVAGVGSPPTSTS--TAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT------QLLQQQQ-----------------------------------------------------------------------------------QQQQHQQQQIPQS----------------------------------------------------------------------------------------------------SGRLAFPLLG-------------GYGPAAAAAAISYSSFLTSKDELIDVTSVDGNALSETASVS----------------------SQESGASEPVWRPW----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: *. * : *: : *:*:*** ***:*: :****: * *: : :**** :****:.*:: *. . * ::* .. : .* :.:::*:**: .*.:: * * : :. : :::. :* : * *** * *: : . *: :. .**** . ..***** . **.*:. * . :: *.*. . . ** :.* :* ", "identical_positions": 64, "similar_positions": 74, "identity": "13.14%" }, { "cls_id": "homologset.agr.HGNC:16618", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P82930-1", "uniprot_id": "RT34_HUMAN", "id": "P82930-1", "name": "Small ribosomal subunit protein mS34", "aln": "---------------------------------MARKKVRPRLIAELARRVRALREQLNRPRDSQ--------------------------LYAVDYETLTRPFSGRRLPVRAWADVRRESRLLQLLGRLPLFGLGR------------------------LVTRKSWLWQHDEP----CYWRLTRVR-PDYTAQNLDHGKAWGILTFKGKTESEAREIEHVMY--HDWRLVPKHEEEAFTAFTPAPEDSLA----SVPYPPLLRAMIIAERQKNG--------DTSTEEPMLNVQRIR----------------------------------MEP-WDYPAKQEDKGRAKGTPV--------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9JIK9-1", "uniprot_id": "RT34_MOUSE", "id": "Q9JIK9-1", "name": "Small ribosomal subunit protein mS34", "aln": "---------------------------------MARKKVRPRLIAELARRVRALREQRNQPRDSQ--------------------------LYALDYETLTRPHSGRRLPVRAWADVRRESRLLQLLARLPLFGLGR------------------------LVTRKSWLWQHDEP----CYWRLTRVR-PDYTAQNLDHGRAWGILTFKGKSEDTAREIEQVMY--HDWRLVPKHEEEAFTAFTAKPEDRLN----SVPYPPLLRAMILAERQKNG--------DTSVQEPLLNLERTR----------------------------------MRP-WDYPAKQETKGRAKGTPV--------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1QEG6-1", "uniprot_id": "F1QEG6_DANRE", "id": "F1QEG6-1", "name": "", "aln": "---------------------------------MVKKK-RLRLIAEMARKIRAYRELKNRPRDSQ--------------------------RYALDYDTMTRPFSGKKLPVLAWKDVQRETRLFSLLSGMRMFGLGR------------------------LFTRKSWLDEHTEP----CYWKITKVK-VDYTAENMDHGKAWGVLTFRGKEEPKEREVDKVMY--HDWRLVPKHEEEEFRRCEPVPEPAAR----SVRYPPLLRAMILAQQAKEQG-----VEVSTLPEPLLPLKRVV----------------------------------TLN-QEYFRRQDELKKQEGTPV--------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VV39-1", "uniprot_id": "Q9VV39_DROME", "id": "Q9VV39-1", "name": "", "aln": "----------------------------------------------MAQKV-------------------------------------------IKYIGRTTDFRG--------------NTLWELVSNLPNWGVGR------------------------LLIRN-MFQRYPEP----CYMRILKVQSVDEQPGEIRKVRVTVEKTWRGVTQPKPVEIYSTSYK-ADYELVPQDQEAKYLNNKKKVEPVILPT--KIELPPLLRELVSEETGNPN-------PQMKVHYKLTDNKMAR----------------------------------LAKDGEKPTVNFALGVGQPKPVSAKLYEGLL-----------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0ABK0LAI2-1", "uniprot_id": "A0ABK0LAI2_RAT", "id": "A0ABK0LAI2-1", "name": "SPRY domain-containing SOCS box protein 3", "aln": "MMTPRTRTYFRILIQWSCEIFLIALPKANRNFGSGLTGCASLLTAVLSRETRPRAKLSDSPPSAAGPMQRGGGDCLRRDRNGKWVSPGGARWLQVLFTMARRARSSRAWHFVLSAARRDTDARAVALAGNSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEGECLAVGTCAGLGRFSGLEGSTLLCPSLVWAFYPTDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCSHWTSPAPPPGTAAPAAERDSRETRPCQRKRCRRS", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :::. : : . :. :* . . : : * : * : . . * * . * : : * . : : .: . . : . : . . * ", "identical_positions": 8, "similar_positions": 33, "identity": "1.64%" }, { "cls_id": "homologset.agr.HGNC:1662", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q64314-1", "uniprot_id": "CD34_MOUSE", "id": "Q64314-1", "name": "Hematopoietic progenitor cell antigen CD34", "aln": "MQVHRDTRAGLLLPWRWVALCLMSLLH-----LNNLTSATTETSTQGISPSVPTNESVEENITSSIPGSTSHY-LIYQDSSKTTPAISETMVNFTVTSGIPSGSGTPHTFSQPQTSPTGILPTTSDSISTSEMT---WKSSLPSINVSDYSPNNSSFEMTSPTEPYAYTSSSAPSAIKGEIKCSGIREVRLAQGICLELSEASSCEEFKKEKGEDLIQILCEKEEAEADAGASVCSLLLAQSEVRPECLLMVLANSTELPSKLQLMEKHQSDLRKLGIQSFNKQDIGSHQSYSRKTLIALVTSGVLLAILGTTGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGASPETQGKANVTRGAQENGTGQATSRNGHSARQHVVADTEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B1PLB1-1", "uniprot_id": "B1PLB1_RAT", "id": "B1PLB1-1", "name": "", "aln": "MPVHRGARAGLLLPWGWVALCLMSLLH-----LNNLTSVASENSTQGVFPPVPTNESTEESITSSIPGSTSHYYLIGQDSNKTTPAISETTVNFTATPGTPSGSGTPHTFSQPQTYPTVTLPTTSDSTSTPEVEHSTWNTSLPSVNVSDYSPNNVSSEMISTTEPCAHTSSSVPSIIKGDIKCSGIRGVPFTQGICLELSEASSCEEFKKERGEELMQILCKKEETEADAGTSVCSLNLAQSEVRPECLLMVLANSTELSSKLQLMEKHQSDLRKLGIQSFNKQDLGSHQSYSRKTLIALVTSGVLLAILGTTGYFLMNRRSWSPTGERLELEP---------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P28906-1", "uniprot_id": "CD34_HUMAN", "id": "P28906-1", "name": "Hematopoietic progenitor cell antigen CD34", "aln": "MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLH-PVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETT---LKPSLSPGNVSDLS-TTSTSLATSPTKPYT-SSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *:*.:*** :* *.****:*** *:* :.:.* .*** . *.** * :*. *.* **** : : *...::*. *:** *:** *. .* *..:: *.** : **. . **.* :.**.. **** * .. : *.*:* : :**. * **.:******* * ::****** .::*** ****::** * ::** :*:::****:.**** ********:***:**** **:.******:******:**** .*.:**:.******:**********.***:** ****************** :* ", "identical_positions": 177, "similar_positions": 82, "identity": "45.27%" }, { "cls_id": "homologset.agr.HGNC:16626", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z1C7-1", "uniprot_id": "RPGF4_RAT", "id": "Q9Z1C7-1", "name": "Rap guanine nucleotide exchange factor 4", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMVAFKEQLAELEKTVKQISEDAKAPQKKHKVLLQQ----FNTGDERAQKRQPIRGSDEVLFKVYCIDHTDTTIRVPVAASVKEVISAVADKLGSG---EGLIIVKMNSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVLELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKCIKIAAHCKEYKNLNSFFGIVMGLSNVAESRLALTWEKLPSKFKKFYAEFESLMDPSRNHKAYRLTAAKLEP---PLIPFMPLLIKDMTFTHEGNKTFIDN--LVNFEKMRMIANTARTVRYYRSQPFNPDAAQAN-KNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EQZ6-1", "uniprot_id": "RPGF4_MOUSE", "id": "Q9EQZ6-1", "name": "Rap guanine nucleotide exchange factor 4", "aln": "-----MVAAH-AAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAH--------------TITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDE---REDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQ-ERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQ----FNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSG---EGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEP---PLIPFMPLLIKDMTFTHEGNKTFIDN--LVNFEKMRMIANTARTVRYYRSQPFNPDAAQAN-KNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WZA2-1", "uniprot_id": "RPGF4_HUMAN", "id": "Q8WZA2-1", "name": "Rap guanine nucleotide exchange factor 4", "aln": "-----MVAAH-AAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAN--------------TITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDE---HEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQ-EKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQ----FNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSG---EGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEP---PLIPFMPLLIKDMTFTHEGNKTFIDN--LVNFEKMRMIANTARTVRYYRSQPFNPDAAQAN-KNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q4T0-1", "uniprot_id": "A0A8M9Q4T0_DANRE", "id": "A0A8M9Q4T0-1", "name": "Rap guanine nucleotide exchange factor 4", "aln": "MISPKMVAAHTSSHPSASADWIVCLDKRPEERSGEDVDIIMVRLKSVKAFEKFHPPLLQQICLCGFYECLEKGITLYRQGDIGTNWYTVLSGSLDVKVSETANH--QDAVTICTLGIGTAFGESILDNTPRHATIVTREFSELLRIEQKDFRNLWENYRQCMAGLLVPPYGVMDSGPNADRMPDKENLSNSSPGLSPKHLNKKSFIENPIKVHPKPINQVPSEKILRAGKVLRNIILSRAPHMIRDRKYHLKTYRRSCIGTELVDWLLQHTSCVHSRVQAVGMWQVLLEEGVLNHVDQEPTFQDKYLFYRFLDDE---SEDSGMPSEEDKKESDEELQDTLLLLSQIGPDAHLRMILRKQPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDFCHFLRVDKEDFNRILRDVEANTVRLKEHEEDVLVLEK------ANNRSSSSSPLKYTVMSGTPEKILEHLLETMKLDCQFSES-DPALDDFLLMHCVFVPNSQLCPLLMTHYHAQASQGSEQ-ERMDYTLNNKRRVVRLVLQWASINTDHLQEEDSSFSFIQEFYEMVCEDSRLTPALKDHLPELEKIIKQNSDDGRPSQKKHKVLLRQ----FSTGNDRLQKRQPIKSTDEILFKVYCSDHTYSTIRVPVSASVREVIAAVSDKLSSG---DDLLLIHLNSAGDKELLKPSDVSIFSSLSINGRLFVCPRDQIDSLTPLPEQEGPSAGSMSTFELMSSKDLAHQMTLYDWELFHCVHEHELIYHTFGRHHFKKTTANLDLFLRRFNEVQLWVVTEVCLCPALSKRVQLLKKFIKIAAHCKEFKNLNSFFAIIMGLGNPAVCRLSQTWEKLPSKFKKFYGEFENLMDPSRNHRAYRLTMAKLEP---PIIPFMPLLIKDMTFTHEGNKTFTDR--LVNFEKMRMIANTVRIIRYCRSQPFDQEAPQATGKSHQDVRTYVRHISVIDNQRSLSQLSHRLEPRRT-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z6P8-1", "uniprot_id": "A1Z6P8_DROME", "id": "A1Z6P8-1", "name": "", "aln": "----------------MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTN--CKLKNGFGPSVQATAAATSPTKRPLSPDHPN-----------PALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLER------VAKQRGQHSAFKYTVMSGTPAKMLEHLLETR--LGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGN-ATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP---PLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPK--SEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25300-1", "uniprot_id": "BUD5_YEAST", "id": "P25300-1", "name": "Bud site selection protein 5", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPKNKYVYICVEYIYIYFAKIHKQSTLS------------SDTTKMFVLIDNVLAYLLEQDD---------------------------------LFVTARFAIQGQIVSRRVNKIHISNITDVLLQQFISHTLPYNDNIVPKKILDSMRTAVRQLLEATACVSRECPLVKRSQDIKRARKRLLSDWYR--------LGADANMDAVLLVVNSAWRFLAVWRPFVNSIQH----------------------------ATQELYQNIAHYLLHGNVNIQRVTALIQLVMGQDDLLFSMDDVLQEVFRIQLYLN---KMLPHNSHKWQKPSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKNKHKNHSVPRLIQIWVESYWQDS--ETTLKDILNFWYSHLAEYYEYQELFADIVQLFINK------------------KRTRQLKIHYIGLTDKEIEENKPPLDYENLFLQYEIDKTNAN------------------------DELCGATDLSDLLFQWKQGELLEVEAFALNVSPWS-------------LAKTLTLLESSLYLDIETIEFTRH------FKHNDTTIDSVFTLSNQLSSYVLETTLQQTHT------ISYWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPIDVKS---DHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIRDGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSNTTARSLLGAMIKVHTLYNDNKDRAYQVSIAKVPRLT-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::: : . :: ::: *. . . : . . :: . : :: :: .. . * . . ** . .: :.. ** : .: : : : * ** :* : .*: : *: * * : :.:* .: *::. ::: . : :::* * :***:: .:: .* * : ** . : . ::: .:: ::.*..*:..** :: * :** .**::*:** ::**.* . **::*:. ::: :: :.: . . **: :* * ", "identical_positions": 47, "similar_positions": 116, "identity": "4.47%" }, { "cls_id": "homologset.agr.HGNC:16627", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z265-1", "uniprot_id": "CHK2_MOUSE", "id": "Q9Z265-1", "name": "Serine/threonine-protein kinase Chk2", "aln": "MKSHHQSHSSTSSKAHDSASCSQSQGGFSQPQGTPSQLHELSQYQGSSSSSTGTVPSSSQSSHSSSGTLSSLETVSTQELCSIPEDQEPE-----EPGPAPWARLWALQDGFSNLDCVNDNYWFGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHSGNGTFVNTELIGKGKRCPLSNNSEIA---LSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPS-VETEIEILKKLNHPCIIKIKDVFDAED------YYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQ----------------EEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQEKNSVTLPVAPAQTS-SQKRPLELEVEGMPSTKRLSVCGAVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O96017-1", "uniprot_id": "CHK2_HUMAN", "id": "O96017-1", "name": "Serine/threonine-protein kinase Chk2", "aln": "---MSRESDVEAQQSHGSSACSQPHGSVTQSQGSS------SQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIA---LSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILKKLNHPCIIKIKNFFDAED------YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQ----------------EEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BC68-1", "uniprot_id": "A0A8M2BC68_DANRE", "id": "A0A8M2BC68-1", "name": "", "aln": "-----------MSEEAGPSGESQSQ-TQSQTQSQP------------ASSSSSAPTSSSQGSSSGSGTLSSVDTVPVQELQSIPEDEE-------EVQPQVWGRIIPLKQGFSVLNCTENQYSFGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRDEN-----LVYLEDLSGNGTWVDDEKLGNGKQSLLSNNSVIA---LAEQKHQVFMFIDKMADDQANLPLEFSKKYHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHDFPS----IGTATRN-AEREIEILKKIDHPCLIKTEDFYQTEDS-----YYIVLEYIEGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASH----------------DDICLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTHASTVGYTKAVDYWSLGVLLFICLGGYPPFNTECTTMSVREQIINGEYRFIPSQWKNVSNEAKDLVKKLLVVDPQKRLSVEEALEHPWLKDDRMRQNANQLMN-----PGAANQPMRPEATRQKRKAHEGEGEPSSKRKPGP----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O61267-1", "uniprot_id": "LOK_DROME", "id": "O61267-1", "name": "Ovarian-specific serine/threonine-protein kinase Lok", "aln": "-----------MARDTQGTQGTQSQASNIWTQVES-------------------QPMEKIVWGRLYGKNIKIKSLGTSSKY----------------------RIIYTHSSFS-VDLNNDEFTAGRGEANDLILTLNDLP--EKILTRISKVHFIIKRANCELTNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVIS---LSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDS-----VYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETN----------------DEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTP-AAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEENFLEPPTKRSRR----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39009-1", "uniprot_id": "DUN1_YEAST", "id": "P39009-1", "name": "DNA damage response protein kinase DUN1", "aln": "-------MSLSTKREHSGDVTDSSFKRQQRSNKPS----------SEYTCLGHLVNLIPGKEQKVEITNRNVTTIGRSRSCDVILSEP---------------DISTFHAEFHLLQMDVDNFQRNLINVIDKSRNGTFINGNRLVKKDYILKNGDRIVFGKSCSFLFKYASSSSTDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQ------QNDDQKKNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTKKG---YTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFND--IQQQSSVSLELQRLQITDNKIPKTYSELSCL----------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. .: . . .: :: . : : * :: ::: . : : : . . . * .. : * :.. .::. : :: : . . * : . * : : :*:* . *: . : .* ::.*:* . . . * :*: .:.** ::. : *:*** : .*:*: :: :. * : .* * *: .::***:..* ***:**:*:** : :*::**. :*: : .. .****** *:****: . *. ** ** **:*: ** * **. . :** ...: : * .:.: . *:.::*:::*. * . ::.*. .*:.* : :: . : ", "identical_positions": 75, "similar_positions": 141, "identity": "12.98%" }, { "cls_id": "homologset.agr.HGNC:16628", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BFQ6-1", "uniprot_id": "DIRC2_MOUSE", "id": "Q8BFQ6-1", "name": "Solute carrier family 49 member 4", "aln": "MGSGWSSEEEERQPLLGPGLGPAPGAARRGRE-ATAVLPAAGPNPGRVYGRRWLVLLLFSLLAFAQGLVWNTWGPIQNSARQAYGFSGWDIALLVLWGPIGFLPCFAFMWLLDKRGLRVTVLLTSFLMVLGTGLRCIPVSDLALKKRLIHGGQILNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTAPLLAAESSRAHIKDRIETVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSFCRLLSNLRFLMIALAYAIPLGVFAGWSGVLDLILTPVHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFVTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q66H95-1", "uniprot_id": "DIRC2_RAT", "id": "Q66H95-1", "name": "Solute carrier family 49 member 4", "aln": "MGSGWSSEEEERQPLLGPGLGPAPGATRRGRE-AAAVLPAAGPSPGRVYGRRWLVLLLFSLLAFAQGLVWNTWGPIQNSARQAYSFTGWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPVSDLTLKKRLIHGGQILNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTAPLLTAESSRDHIKDRIETVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSFCRLLSNLRFLMIALAYAIPLGVFAGWSGVLDLILTPVHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSVTHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFVTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96SL1-1", "uniprot_id": "DIRC2_HUMAN", "id": "Q96SL1-1", "name": "Solute carrier family 49 member 4", "aln": "MGSRWSSEEE-RQPLLGPGLGPGLGASWRSREAAAAALPAAVPGPGRVYGRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFLTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** ****** ***********. **: *.** *:*.**** *.********************.*******************.*:.******************************:*******************:*** **:*******:**********************************************************:***:***** *******:******************************************.******:*****************************.*************************************************************:**************************************************************:*******************************************", "identical_positions": 449, "similar_positions": 22, "identity": "93.74%" }, { "cls_id": "homologset.agr.HGNC:16629", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z1C8-1", "uniprot_id": "RPGF3_RAT", "id": "Q9Z1C8-1", "name": "Rap guanine nucleotide exchange factor 3", "aln": "-----------------------------------------------------------------------MKVSWPGENHWQVGPAVVESPAVGAPQVGG--------LPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRR--------------------PSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPE-----PQPAGTHD----VEEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELVHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTRGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRL---SNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKG---QVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSP---PVIPFMPLLLKDMTFIHEGNHTLVEN--LINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCC8-1", "uniprot_id": "RPGF3_MOUSE", "id": "Q8VCC8-1", "name": "Rap guanine nucleotide exchange factor 3", "aln": "-----------------------------------------------------------------------MKVSWPGENHWQVGPAVVESPAVGAPQVGG--------LPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRR--------------------PSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPE-----PEPTGTQD----VEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARL---SNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKG---QVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQ--------EHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSP---PVIPFMPLLLKDVTFIHEGNHTLVEN--LINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95398-1", "uniprot_id": "RPGF3_HUMAN", "id": "O95398-1", "name": "Rap guanine nucleotide exchange factor 3", "aln": "-----------------------------------------------------------------------MKVGWPGESCWQVGLAVEDSPALGAPRVGA--------LPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQR--------------------PSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPE-----PEPVRTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP---AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRL---SNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKG---QVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSP---PVIPFMPLLLKDMTFIHEGNHTLVEN--LINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B9K2-1", "uniprot_id": "A0A8M2B9K2_DANRE", "id": "A0A8M2B9K2-1", "name": "", "aln": "----------------------------------------------------------------------MEEIHARMFSFFKQILSAKKKNRLESPAVMC--------SADTLLRSTLR-----------------------------------------------SSLQKTPLP---DAVDTQDTIKQFLSDRILKAARVVYSTLMEGNPGLIRDRKHHLKTYRQCCSGKELVDWLMKLNDCFQSRSQAVGMWQVLVDEGILGHVKQELNFHDKDTQFYRFMEAE-----FDLNHTTNEKDSKDDELQESLSLLIQMGPDALLTMILRKCPSQRTPEDLEVIYEELLHVKAVAHLSTSVRKELASVLVFESHAKAGTVLFSQGDKGTSWYIIWRGSVNVITHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFIRILKDVEANTVRLEEHGKVVLVLEKS------SAQDTPSCNKYTVMSGTPEKILEHMLEAIKLETNGADFIDPCVTDFLLTHPVFMPCSQLCAALQHHYQAEP---SEGSDLEKAAYALNTKQKVVKLVCHWVALFALLLRDDPVASEFLEKFREGVMADSRL---SSMLREQLRDRRKTKIMENGCHTLT---KLNQKFDWFSAYEEPVG-KLRSIKAQDKVLYEIFKPDHKAVTVMLPVDASVNDILTTLVDPD---RN---YVLVKMNSSGDRVQLKLETTAVSASLGVNEKLFLCTSSQVEQLTPDKEQLGPEKSTMDTLEQICSKDMASQHTSYDWELFMAMHEVELVYYVFGREKFPGSTTANLERFVRRFNEVQYWVVTELCLCEDLGKRAILLKKFIKMAVVLKEQKNLNSFFAVMFGLSNSAVQRLNKTWERLPNKTKRIYCAYERLMDPSRNHRAYRLTIAKLSP---PYIPFMPLLLKDMTFIHEGNKNYTDK--LVNFEKMRMIARTVKTVRDCRSQPYVPSSPQKGLTERMFLDAQAIRISTYSDQSLNLRSATSIRQYIQNLKVIDNQKKLTQLSRALER----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z6P8-1", "uniprot_id": "A1Z6P8_DROME", "id": "A1Z6P8-1", "name": "", "aln": "MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDK-CFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAK-----QRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGG--MDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAH--EDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGN--ATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFG-KITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP---PLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFEKMHMMAQTMRTIRFCRSRSLGLEPP-------------------------SPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25300-1", "uniprot_id": "BUD5_YEAST", "id": "P25300-1", "name": "Bud site selection protein 5", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPKNKYVYICVEYIYIYFAKIHKQSTLSSDTTKMFVLIDNVLAYLLEQDDLFVTARFAIQG--------QIVSRRVNKIHISNITDVLLQQFISHTLPYNDNIVPKKILDSMRTAVR------------------------------------------------QLLEATACVSRECPLVKRSQDIKRARKRLLSDWYRLGADANMDAVLLVVN-SAWRFLAVWRPFVNSIQH-----ATQELYQNIAHYLLHGNVN-----IQRVTALIQLVMGQDDLLFSMDDVLQEVFRIQLYLNKMLP-----------------HNSHKWQKPSPFDSANLLLNFR-----DWTTDNALLQELLLSYPTIN------------------------------KNKHKNHSVPRLIQIWVESYWQDS--ETTLKDILNFWYSHLAEYYEYQELFADIVQLFINKKRTRQLKIHYIGLT----------------------------DKEIEENKPPLDYENLFLQYEIDKTN------------------------------------ANDELCGATDLSDLLFQWKQGELLEVEAFALNVSP-------------WSLAKTLTLLESSLYLDIETIEFT------RHFKHNDTTIDSVFTLSNQLSSYVLETTLQQTHTIS-------YWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPID---VKSDHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIRDGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSN----------------------TTARSLLGAMIKVHTLYNDNKDRAYQVSIAKVPRLT--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : . *: : ::. * . * : .: : .: :.*::: : : : : . : * : .* : .:. : :: *: : ..:: .::*: . .. : : : *: : : :* . :::.: * .:. : : * :.::.: : ** :..*:: : : :* :. . :* . : :*: :. : ::**:: .: : .: : ::: ** :. .::: : : : : : : . . ..: *: : : : : . .:. :* .: : : * .:* * : .*: :. : .:: *: . * : .* : * * . ::::* :***:: ::: .*.* ::.** . : * ::: : ::.*. *:..** : :: * :** .**::*:** ::**.. . :*::*:. ::: : :.: . :* : : :::: : ", "identical_positions": 59, "similar_positions": 216, "identity": "5.62%" }, { "cls_id": "homologset.agr.HGNC:1663", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q07969-1", "uniprot_id": "CD36_RAT", "id": "Q07969-1", "name": "Platelet glycoprotein 4", "aln": "MGCDRNCGLITGAVIGAVLAVFGGILMPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVG-TENDNFTVLNLAVAAAPHIYTNSFVQGVL------NSLIKKSK-----------------------------------------------SSMFQTRSLKELLWG----------YKDPFLSLVPYPISTTVG----------VFYPYNNTVDGVYKVFNGKDNISKVAIIDTYKGKRNLSYWE--------SYCDMINGTDAASFPPFVEKSQTLRFFSSDICRSIYAVFESEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNN-----CTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIKLLGLVEMVLLGVG-VVMFVAFMISYCACRSKNGK-------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q08857-1", "uniprot_id": "CD36_MOUSE", "id": "Q08857-1", "name": "Platelet glycoprotein 4", "aln": "MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVG-TEDDNFTVLNLAVAAAPHIYQNSFVQVVL------NSLIKKSK-----------------------------------------------SSMFQTRSLKELLWG----------YKDPFLSLVPYPISTTVG----------VFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWP--------SYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNN-----CTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMVEMALLGIG-VVMFVAFMISYCACKSKNGK-------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P16671-1", "uniprot_id": "CD36_HUMAN", "id": "P16671-1", "name": "Platelet glycoprotein 4", "aln": "MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVG-TEADNFTVLNLAVAAASHIYQNQFVQMIL------NSLINKSK-----------------------------------------------SSMFQVRTLRELLWG----------YRDPFLSLVPYPVTTTVG----------LFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWE--------SHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISKN-----CTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVG-VVMFVAFMISYCACRSKTIK-------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E1JI63-1", "uniprot_id": "SNMP2_DROME", "id": "E1JI63-1", "name": "Sensory neuron membrane protein 2", "aln": "MIHWSLIVSALGVCVAVLGGYCGWILFPN---MVHKKVEQSVVIQDGSEQFKRFVNLPQPLNFKVYIFNVTNSDRIQQG-AIPIVEEIGPYVYKQ-FRQKKVKHFSRDGSKISYVQNVHFDFDAVASAPYTQDDRIVALNMHMNAFLQVFEREITDIFQGFANRLNSRLNQTPGVRVLKRLMERIRGKRKSVLQISENDPGLALLLVHLNANLKAVFNDPRSMFVSTSVREYLFDGVRFCINPQGIAKAICNQIKESGSKTIREKSDGSLAFSFFGHKNGSGHEVYEVHTGKGDPMRVLEIQKLDDSHNLQVWLNASSEGETSVCNQINGTDASAYPPFRQRGDSMYIFSADICRSVQLFYQTDIQYQGIPGYRYSIGENFINDIGPEHDNECFCVDKLANVIKRKNGCLYAGALDLTTCLD-APVILTLPHMLGASNEYRKMIRGLKPDAKKHQTFVDVQSLTGTPLQGGKRVQFNMFLKSINRIGITENLP-TVLMPAIWVEEGIQLNGEMVAFFKKKLINTLKTLNIVHWATLCGG-IGVAVACLIYYIYQRGRVVEPPVK---------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VDD3-1", "uniprot_id": "SNMP1_DROME", "id": "Q9VDD3-1", "name": "Sensory neuron membrane protein 1", "aln": "MQVPRVKLLMGSGAMFVFAIIYGWVIFPK---ILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEG-AKPRLQEVGPFVFDE-WKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQREKAAMMELVSKGLSIVFPDAK------------------------------------------------AFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWPD-------GECNTFVGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLD---LGDIRADEKLHCFCEDPEDLDT-----CPPKGTMNLAACVG-GPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMEPVEGIEPMKNLP-KLILPMFWVEEGVQLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDINSILKDNNKVDDVASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . : .. * :::* ::. :.:.*.:: *: : : : : .::*:* *.: : . : ::: **:.: : * . .:*: *:. * * :.: : : . .. . . . : .: ::: : : . ..: . . . .: * : : * * : :: : . .. : . * . *: : ***:: :.* :: : *:.*:***: : . . :*:* *: : : . : . *** : * *.::: * *: ::**: .. . : **:*: ..* .::*.: ::* .:* .**:*.*: ::. . * :** ::* :*::* :. . :.: : :: .::. : . : : .: : * . : ", "identical_positions": 59, "similar_positions": 170, "identity": "9.5%" }, { "cls_id": "homologset.agr.HGNC:16631", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GIV1-1", "uniprot_id": "A0A8I6GIV1_RAT", "id": "A0A8I6GIV1-1", "name": "", "aln": "MRLDMSQGKPNSPTQSSDPFQQSSGARTRKHCAHPAACCLIQNWAKVQGCVKVERPKAANAWLSSTLKGESLCSLRRRSSWVVKPHAPLIKFPNRRDKPKLSASDTLR--SAALP--SHSSVISQHSKGN--LSPNLLMHQ-GPPDTAELIKSLPQKYRRKPMSQEEMEFIQRGGPE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQX8-1", "uniprot_id": "KGD4_MOUSE", "id": "Q9CQX8-1", "name": "Alpha-ketoglutarate dehydrogenase component 4", "aln": "-------------------------------------------------------------------MGSKMASATR-VVQVVKPHAPLIKFPNRRDKPKLSASEALG--SAALP--SHSSAISQHSKGS--TSPDLLMHQ-GPPDTAEIIKSLPQKYRRKPMSQEEMEFIQRGGPE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P82909-1", "uniprot_id": "KGD4_HUMAN", "id": "P82909-1", "name": "Alpha-ketoglutarate dehydrogenase component 4", "aln": "------------------------------------------------------------------MMGSKMASASR-VVQVVKPHTPLIRFPDRRDNPKPNVSEALR--SAGLP--SHSSVISQHSKGS--KSPDLLMYQ-GPPDTAEIIKTLPQKYRRKLVSQEEMEFIQRGGPE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8WHV7-1", "uniprot_id": "A8WHV7_DANRE", "id": "A8WHV7-1", "name": "", "aln": "--------------------------------------------------------------MGSKVSG-KMAAASR-VVQVVRPHAPLIKFPDRKGVSRPNVQEALKVLTASLPQLSQSTAPSAASVSPPPRPPGPASRLPGTPDSIAVVRELPQRYRRRTLDLNEMDYIQRGGPE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .:.: * **:**:***:**:*:. .: ...::* :*.** *:*:. * * . .*. *.**: ::: ***:***: :. :**::*******", "identical_positions": 39, "similar_positions": 37, "identity": "22.03%" }, { "cls_id": "homologset.agr.HGNC:16632", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B0BN56-1", "uniprot_id": "RT31_RAT", "id": "B0BN56-1", "name": "Small ribosomal subunit protein mS31", "aln": "-------MLHRIPAFIRPRPFSGLP-----------------LSCGNREVSVAASVLPAAGSGAVR---------TENTIQRHFCTSRSICSKKDD---------QSVPANETSQKAAESQGEGKE-TLKKNLLDVIKDMKVQLNTAN-VKTTKPR---GRQPPAHLETAVGRLQKALGEPPRKRNEFLSPELVAAASAVADSLPFDKQTTKSELLKQLQQHEEESRAQTDRQKRRVSFTQIISNMKIAKSPSMRVSSRPQHQIQFDEE-----VDSSLSQEKPADFRRRKCLFKGKRLSIFDVKAFDDEAPEPEAAPSLWEIEFAKQLATVSEQPFGNGFEEMIQWTKEGKLWEFPVNNEAGLDDDGSE-FHEHIFLEKHLEDFP-KQGPIRLFMELVTCGLSKNPYLSVRQKVEHIEWFRNYFNEKRDILKENNIHLTS-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61733-1", "uniprot_id": "RT31_MOUSE", "id": "Q61733-1", "name": "Small ribosomal subunit protein mS31", "aln": "-------MLHRIPAFLRPRPFSGLP-----------------LSCGNRDVSVA--VLPAAQSGAVR---------TENNIQRHFCTSRSICSKKVD---------QSVPANEISQKAAESQGRGKE-TLKKDLLDIIKDMKVDLSTAN-VKTPKPR---GRKPSASLEATVDRLQKAPEDPPKKRNEFLSPELVAAASAVADSLPFDKQTTKSELLRQLQQHEEELRAQKDREKRRISFTHIISNMKIAKSPSGRASTRPQHQIQFDED-----MDSSLKQEKPTDFRKRKYLFKGKRLSIFADKAFADEPPEPEASPSLWEIEFAKQLASVADQPFENGFEEMIQWTKEGKLWEFPVNNEAGLDDDGSE-FHEHIFLDKYLEDFP-KQGPIRLFMELVTCGLSKNPYLSVKQKVEHIEWFRNYFNEKRDILKENNIAFT------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92665-1", "uniprot_id": "RT31_HUMAN", "id": "Q92665-1", "name": "Small ribosomal subunit protein mS31", "aln": "-------MFPRVSTFLPLRPLSRHP-----------------LSSGSPETSAAAIMLLTVRHGTVRYRSSALLARTKNNIQRYFGTNSVICSKKDK---------QSVRTEETSKETSESQDSEKE-NTKKDLLGIIKGMKVELSTVN-VRTTKPP---KRRPLKSLEATLGRLRRATEYAPKKRIEPLSPELVAAASAVADSLPFDKQTTKSELLSQLQQHEEESRAQRDAKRPKISFSNIISDMKVARSATARVRSRPELRIQFDEG-----YDNYPGQEKTDDLKKRKNIFTGKRLNIFDMMAVTKEAPETDTSPSLWDVEFAKQLATVNEQPLQNGFEELIQWTKEGKLWEFPINNEAGFDDDGSE-FHEHIFLEKHLESFP-KQGPIRHFMELVTCGLSKNPYLSVKQKVEHIEWFRNYFNEKKDILKESNIQFN------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2BEP0-1", "uniprot_id": "A2BEP0_DANRE", "id": "A2BEP0-1", "name": "Small ribosomal subunit protein mS31", "aln": "MYRRLLINIHQVRNGLIHAQKTRTPSVKCKENEGFAHTFWTTGSTSHRPLGTSSICFSDNKESSTSLSDDKEKRREENEAKAEVGTDGQRNTEIKKGPDISNTALTSELETEVELKPKEIKKPEKEKTGKESLLELLGAMKVDVTTVRKVRPPRFPRISEKPSTDQMESTQSMFQDAMAEGSKQR-ETLNPALVAAASAAASTLP-NSQQVESELLQQLRKHEAEPDAQRADRQ---NIGDIIADMKVGKRQMGRSNSRPSNQIRFDDDGQGYTEDRSITSELMNGIHRRKNSFTGKRLNIFSP-GMEQESSE--MGPTLWDIDLANQIVQSTNQMPRNGFEEMMQWTKEGKLWQYPINNEAGLDEEASVPFHEHVFLEKHLESFP-RQGPVRHFMELVITGLSKNHHLTVQQKQEHIAWFRDYFQQKDDVMKEAQA---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VUX1-1", "uniprot_id": "Q9VUX1_DROME", "id": "Q9VUX1-1", "name": "Small ribosomal subunit protein mS31", "aln": "--------MLAVRSSQRLGLRSLLP-----------------SAFKNVGLVNYSSSQSKNDDGYSS-------SDDEKPTKKKEEPVETAAQRLNR--------LLGTMQATDQLSASDFPRPGDANRKRREAQKQEAAAKNVLTAAKNIASMLGT-----SESDKKQTESELLAKLLGHGSESSSAATGENQTADVSGSP---SGDKELNLSDIIVGMKIDRRQQPQQVEQTRGEYVRRSLASRFKPQNRDGAYQRSQRQ------------------TKREAESFTGSVNLYGGEPLGIFKD----TQLPISNDILSTWSQLSERELSLQASHPPANYFEQMVLWTDQKKVWRFPINNEQDWEDEHNVDFSEHIFLEQHLEDWCPSKGPIRHFMELVCVGLSKNPYLTAQEKKDHIFWFRDYFQAKKDILRDLISKEPSKSISA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : * : . :: : . . . . .. : . :.. * :.:.. : . :: : ... . .* .*. . . :.: *::: :: .. : * : : : :* . :: . .. .: : *: *.** : . : *. .:: .: * **::: **.: *:*.:*:*** . ::: . * **:**:::**.: :**:* ***** ***** :*:.::* :** ***:**: * *:::: ", "identical_positions": 54, "similar_positions": 107, "identity": "12.11%" }, { "cls_id": "homologset.agr.HGNC:16633", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R2L5-1", "uniprot_id": "RT18C_MOUSE", "id": "Q8R2L5-1", "name": "Small ribosomal subunit protein bS18m", "aln": "-MAALVALCSGIGRKNLT---TAAGCFTDRGTQAVSVIWRRCFSQFEQVTSNEDL------------------PVPM-------ENPYKEPL-----------------KK------------------------------------------------------------------------------------------------CVLCEK----RVDYKNVQLLSQ---------------FISPFTGC--IYGRHITGLCGKKQREITKA-----IKRAQKMGFMPVTYKDPAYLKDPR--------------------------------------------------------------------VCNIRYRE---------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y3D5-1", "uniprot_id": "RT18C_HUMAN", "id": "Q9Y3D5-1", "name": "Small ribosomal subunit protein bS18m", "aln": "-MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTH--TVLWRRGCSQ--QVSSNEDL------------------PISM-------ENPYKEPL-----------------KK------------------------------------------------------------------------------------------------CILCGK----HVDYKNVQLLSQ---------------FVSPFTGC--IYGRHITGLCGKKQKEITKA-----IKRAQIMGFMPVTYKDPAYLKDPK--------------------------------------------------------------------VCNIRYRE---------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0LDD4-1", "uniprot_id": "A0ABK0LDD4_RAT", "id": "A0ABK0LDD4-1", "name": "", "aln": "-MAGLLALRSCIGRKNLT---TATGCFTDRATHAVSVPWRRCFSQYEQVTSNEDLWATLRIEKGAPKESVLKSPASMGI-IQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFHYISPKLTIVWVLGVLVRYCFLLPLRVTLAFIGISLLIIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRSLSGTIHYHNKQYRPQKGGICVANHTSPIDVLILATDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEIKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYNPQFGDAFWNSSKYNLVSYLLRIMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAVQGGLTELPWDGGLKRAKVKDTFKEEQQKTYSKMIVGNGSPSLALDSSTVDNHGSPEPAFRSESL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VA81-1", "uniprot_id": "Q9VA81_DROME", "id": "Q9VA81-1", "name": "", "aln": "--------------------MLKLGKFLAQNATLVNLVGRQQLGTVSRLYSAAPE------------------SSDLDL-PIDIKNPYEKDP-----------QQ------------------------------------------------------------------------------------------------------CILCKHS--IEPHYKNVKLLSQ---------------FQSPYTGR--IYGRHITGLCKRRQEQVEQA-----ILRAQQCLLMPGYHKDLDFLQDPK--------------------------------------------------------------------LFDPERPVRPHKY----------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40033-1", "uniprot_id": "RSM18_YEAST", "id": "P40033-1", "name": "Small ribosomal subunit protein bS18m", "aln": "MQPIIKGAVSSTFKRALYNFGIKEKKSVNIEMGRTQQTKKIDQSLSKKLPKGTIYD-----------------PFDFSMGRIHLDRKYQANKNSNR---------------------------------------------------------------------------------------------------------------NDIMKSGANPLEFYARPRILSR----------------YVTSTGR--IQHRDITGLSAKNQRRLSKA-----IRRCQAIGLM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . :: . . : . : : * . : .: . * : : ** *. : :* : *.: ", "identical_positions": 7, "similar_positions": 23, "identity": "1.5%" }, { "cls_id": "homologset.agr.HGNC:16634", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q0ZFS4-1", "uniprot_id": "Q0ZFS4_RAT", "id": "Q0ZFS4-1", "name": "Small ribosomal subunit protein mS33", "aln": "MPADPGILFLTAGEMSLSEYAVRMSRLSARIFGEVARPTDSKSMKVVNLFSEQPLAKKKETYDWYPN-HNTYFALMGTLRFLGLYRDEHQDFKDEQRRLKKLRGKGKPRKGEGKRATKKK-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D2R8-1", "uniprot_id": "RT33_MOUSE", "id": "Q9D2R8-1", "name": "Small ribosomal subunit protein mS33", "aln": "MSP-------------LSEYALRMSRLSARIFGEVARSTDSKSMKVVSLFSEQPLAKKKETYDWYPN-HNTYFALMGNLRFLGLYRDEHQDFKDEQRRLKKLRGKGKPRKGEGKRATKKK-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y291-1", "uniprot_id": "RT33_HUMAN", "id": "Q9Y291-1", "name": "Small ribosomal subunit protein mS33", "aln": "MSS-------------LSEYAFRMSRLSARLFGEVTRPTNSKSMKVVKLFSELPLAKKKETYDWYPN-HHTYAELMQTLRFLGLYRDEHQDFMDEQKRLKKLRGKEKPKKGEGKRAAKRK-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VEV5-1", "uniprot_id": "Q9VEV5_DROME", "id": "Q9VEV5-1", "name": "Small ribosomal subunit protein mS33", "aln": "MSHKYTELIKVG-----TQYARRMNYLSNRIFGEVARTTNEKSMKVVRMFSEEPIHKRDYVINWYPR-HVETHLLMKNLRDYGLFRDEHQDFKEEMKRLRKLRGKAPPKKGEGKRASKK--------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53305-1", "uniprot_id": "RT27_YEAST", "id": "P53305-1", "name": "Small ribosomal subunit protein mS33", "aln": "MNVP-------------KARLLKVAELSAKIFDQNFNPSGIRTG--SKILNER--LKGPSVASYYGNPDILKFRHLKTLYPDIEFVDLEEQYRLSMVEAKKRRGKGAPKKMKKDAAATAKGKGKKKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . :: ** ::*.: ..:. :: ::.* * . .:* . . : .* : * .::: . . :* *** *:* : . *:. ", "identical_positions": 16, "similar_positions": 36, "identity": "12.6%" }, { "cls_id": "homologset.agr.HGNC:16635", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LYD4-1", "uniprot_id": "A0ABK0LYD4_RAT", "id": "A0ABK0LYD4-1", "name": "", "aln": "MAAASLQLRLT-------LYPGARGLRTFS------SVARPAAPRAGP--LSRG--------ERPMRRK--ALPPRTEKMETD----QDWPSVYPTAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNVELLK--IPNFLHLTPVAIKRHCGALKD-------FCTEWPAALDSDEKCEKHFPVEIDTADYVSSGPSIRNPRARAVTLRVKLSSLNLDNHAKKKLIKLVGERYCKTTDVLTIKTDRCPLKRQNYDYAMYLLTVLYHESWKTEEWEKNKTEEDMDEYVWAKSSSENSVLQTLLQMRAAESSVAPSREELLGTKEVEDYQKCVVRLKNEGENEASLAQYKESVKRLLNLA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BJZ4-1", "uniprot_id": "RT35_MOUSE", "id": "Q8BJZ4-1", "name": "Small ribosomal subunit protein mS35", "aln": "MAAAALQLRQS-------LCPGPRVLRTFS------SVASPAAPRAGPRTASRS--------ERPMRRK--ALPPRTEKMDTD----QDWPSVYPTAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLK--IPNFLHLTPVAIKRHCAALKD-------FCTEWPAALDSDEKCEEHFPVEIDTADYVSSGPSIRNPKARAVTLRVKLSSLNLDNHAKKKLIKLVGERYCKATDVLTITTDRCPLKRQNYDYAVYLLTVLYHESWKTEDWENSKTEEDMDEYVWAKSSSENSVLQTLLQMRAAESSVAPSREELLGTKEVEDYQKCVVRLKNEGENEASLAQYKESVKRLLNLA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P82673-1", "uniprot_id": "RT35_HUMAN", "id": "P82673-1", "name": "Small ribosomal subunit protein mS35", "aln": "MAAAALPAWLS-------LQSRARTLRAFS------TAVYSATPVPTPSLPERTPGN-----ERPPRRK--ALPPRTEKMAVD----QDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLELLK--IPNFLHLTPVAIKKHCEALKD-------FCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYKESVKRLLNVT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q498P2-1", "uniprot_id": "RT35_DANRE", "id": "Q498P2-1", "name": "Small ribosomal subunit protein mS35", "aln": "MAASVSHPALSSFHKISCNITGISGLISFSRRISVSSVLPTSAVAAKRDAAGKGVRG-----QMKPRRQ--AGEPRTERMAVD----QDWTAVYPTAASFKPSAVPLPVRMGYPVNRGVPPAKHGNLELIK--IPNFLHLTPATIKKHCEALKP-------FLTEWPSALDSDEKCTEHFPIQVQSKDFVSSGLSLRNPDARIVTLKVKHSSLNLDDHARKKMIKLAEKRYCKETDTLTITTDSCPLRQQNYDYAMYLLTVLYHESWKSEAWEQEKTRADMEEYEWQDSPSQRNILETLKSIRGTEET-----HELLDQPEVGEYRNSVTQMKNHGETEENLLRYKEAVKKLLQL-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VZX6-1", "uniprot_id": "Q9VZX6_DROME", "id": "Q9VZX6-1", "name": "", "aln": "MSSALTRLLER---LPLKKQTAQSGIRVFSNQEQRQEIEDDEEFRVLSLRTVKQQMQ-----KRQQVRRDPITPPRTGRMAVD----QDWTAVWPGPRSFHPASVPLPLRQGFTERGAAAPSKFANAELMK--IPNFLHLTPPAIRQQCEAIKK-------FCTPWPKGLETEAKWQRHFPLEVTTTDYCQSLPTIRNPEARRVTITLKLSDLKFDAHARDKFLRLVGDRYNKDTDLVTFVTDRCPQKKQNYDYALYLLTACYHESFVTEPWEATKSEADMEVYLFERNQS-KVSAEGILNWNAKKGAP-----KVVPSK---SFAECVEKLINEGENEYNLGKYKEEVKKMLNIA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03976-1", "uniprot_id": "RT24_YEAST", "id": "Q03976-1", "name": "Small ribosomal subunit protein mS35", "aln": "MKVPLGLWKVS----RGNLWSTQKRVLTMSRCLNSDAGNEAKTVREGPAFSADLYMHPEKWKGLPPQRILELYWERMARLGSEYKPNKDELNALLTTSEYSNVPVNDIKKLYHRGEQGAIDIKGGNVNRDNSLRPFMFDELPSQAQELVAQHREQRFYNRLAAYELPLLAQYRQEYKRPSPESHPVTYRYTSYVGEEHPNSRKVVLSVKTKELGLEEKSLHKFRILARSRYDHTTDIFKMSSDKFEHASQNARYLHDILQRLLAESKDLTEDDFSDVPLDTRHTIAKSLRKKKRDYEFPEHWKRPEDAP---------------------------------KKKFDIVDQLLSTL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . . : :* * * :: : :* . . : .* : . . .. * .* : : * ::. * :. : * : : . * . * .:* :* *.: :* ..* :: :: .*: *. .** : ** ..: :* ** * :* ** : . * . . : . : : : *.::*. ", "identical_positions": 34, "similar_positions": 65, "identity": "9.55%" }, { "cls_id": "homologset.agr.HGNC:16636", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88658-1", "uniprot_id": "KIF1B_RAT", "id": "O88658-1", "name": "Kinesin-like protein KIF1B", "aln": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK---NPKEAPKSFSFDYSYWSHTSPEDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLMDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQAGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPK------------------------------------------KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSA--------ETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKREKEEADLLLEQQRLDYESKLQALQKQVETRSL-----AAETTEEEEEEEE--------VPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPTEMGKTHED----RPFPRTVVAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVGSNAQ-DDSETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDAMEDF-DDEAFVDDTGSDAGTEEGSELFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFPSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMNDLDLKSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELNSPPQPSRRFFPPPMPLSRP-------------------------------------------------------------------VPATKLNTMNKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVD--AILSLNIISAKSLKSSHSSS---------RTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSIP-KSMSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLSDISPIGRDPSVSSFSSSTLTPSSTCPSLVDSRSSSMDQKTPEANSRASSP-CQEFEQFQIIPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMLKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQPKY------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q60575-1", "uniprot_id": "KIF1B_MOUSE", "id": "Q60575-1", "name": "Kinesin-like protein KIF1B", "aln": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK---NPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPK------------------------------------------KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSA--------ETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQRQVETRSL-----AAETTEEEEEEEE--------VPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPSEMEKTHED----RPFPRTVVAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVASSAQ-DDSETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDAMEDF-DDEAFVDDTGSDAGTEEGSELFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMNDLDLKSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQDLNSPPQPSRRFFPPPMPLSKP-------------------------------------------------------------------VPATKLNTMNKTTLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVD--AVLSLNIISAKSLKAAHSSS---------RTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSVP-KSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADVESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLSDISPIGRDPSVSSFSSSTLTPSSTCPSLVDSRSSSMDQKTPEANSRASSP-CQEFEQFQIVPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQPKY------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60333-1", "uniprot_id": "KIF1B_HUMAN", "id": "O60333-1", "name": "Kinesin-like protein KIF1B", "aln": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK---NPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPK------------------------------------------KTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSA--------ETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSL-----AAETTEEEEEEEE--------VPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHED----RPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQ-DESETTVTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDF-DDEAFVDDAGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRINDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELNSPPQPCRRFFPPPMPLSKP-------------------------------------------------------------------VPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVD--AILSLNIISAKYLKSSHNSS---------RTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMSDTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSIP-KSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSGDIESLVDREKELATKCLQLLTHTFNREFSQVHGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSLVDSRSNSLDQKTPEANSRASSP-CPEFEQFQIVPAVETPYLARAGKNEFLNLVPDIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQSKY------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TD35-1", "uniprot_id": "A0AB32TD35_DANRE", "id": "A0AB32TD35-1", "name": "plus-end-directed kinesin ATPase", "aln": "MSGASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPK---NPKE-PKTFSFDYSYWSHTSPDDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQEGIIPQLCEELFEKINDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVSRLKELLRAQGLGDILDIEPMGDDCLGSGSKYLKDIHNNKHRYLLASENQRPGHFSTAPMGCLTASPSSGSLCSQAGLQSVSSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKFGPDRPTSLSIEDFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETYVNGKRVNSAVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSA--------ETPVEPVDWTFAQRELLEKQGIDMKQEMEKRLTEMEILYKKEKEEADQLLEQQRLVYESKLQELQKQVETRSL-----AAETPDEEEEEEEEDE-----VPWTQHKYELAQWAFRKWRYHQFTSLRDQLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPPEPEKERDA----RPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDQMREMYDRAGEMASSNQGDDGEGALTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTTDSEITELADERQSEMEDFMDDEAFVDDTSSDAGTEEGSDIFSDGQDPFYDRSPWFILVGRAFVYLSNLLYPVPLVHRVAVVTEKGDVRGFLRVGVQAIAADEEAPDYGSGVRQSGTAKISFDNEYFKKNDFTSVAMTRSGLSLEELRIVEGQGQSSEVITPSEEMNRINEMDLKLG------NVDTKLGDGLAEHLEVGSIFTFRVTVLQASGIPAEYADIFCQFNFLHRHDEAFSTEPLKNTGRGAPLGFYHVQNISVEVTESFIEYIKTKPIVFEVFGHYQQHPLHIHGQDVVSPSQPSRKYYPPPMPLSKPDHARKIELIRYLMSGYVHGQVLDTLSEHANALASTAVASLEEGAYELCHFPFLPIPNCPVFRVPRHDVPATKLNTITKSNLGQCVSKYDLLAWFEISELEPTGEYIPAVVDHTGGLPCHGTYLLHQGIQRRITVTLIHEKGSELHWKDVRELVVGRIRNKPEVDDSAAD--AVLSLNIISAKNLKSSHNSSSLCIDSDISRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAIITKDICMVFYSRDAKISPPRSLRNLFGSGYSKTPDCNKVTGVYELSLCKIADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQWELDKMEQLHEVEKTRHLLLLREKLGETPPPKSLSESLSPSLSSGTLSTSTSISSQISSTTFESAITPSESSGYDSTDIESLVDREKELATKCLRLLTHTFNSEYNQMCNSISDCKFSDISPMGRDPSVSSFSSATLTPSSTCPSLSDSR-------TPEANSRATSPSGSDYENFPMVPILETSYLARAGKHEFLNLVPNIEEMRPGSVVSKKGILNFMEPRSNTWVKHFVVVRRPYVFIYNNDKDPVERGVLNLSTAQVEYSEDQQAMLKTPHTFAMCTKHRGILLQANNDKDMNDWLYAFNPLLAGTIRSKLARRRSGVMKN------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1ZAJ2-1", "uniprot_id": "KIF1A_DROME", "id": "A1ZAJ2-1", "name": "Kinesin-like protein unc-104", "aln": "MS--SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDH-HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVA---SKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEG------IEVQEEDE----------------------------------------------LTKSTVIKSPTKSRNRNGSTT--EMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPK------------------------------------------KTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNS-----TVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRQRLELMREMYHNEAEMSPTSP-DYNVESLTGGDPFYDRFPWFRMVG------------------------------------------------------------------------------------RSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLD-EESIDFNNGVKQS--ARLVFNED-------DAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSAS------ECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQP-------------------------------------------------------------------VRSPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDR----------SFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDARTGP-RSLKHLF-SGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEKDVCNLAARAATSPVHMVIP----QSPQTPVKDPQQIIPERE-YNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDVSPSDEG--CADMTVSCISSNSMENN-----------------KFVIRRRLCSP-----DRADAPNGWEAPAPATQPALPLRLYVPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVECSEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARRTLEPASQTASQIQATNAANANSASK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** *************** .:******:* * :*:* *** *..: * *.******** .*. *::*. **:***:*** *:*:**********************:*** * **** :*::** :*:*. .:::.*****:******************************************.* ** **:* *************************.***:: * *:*:*************************************************** **.*:.**:********.*************:***:**:******:**************** *:**:***.****:****:*: :*::**:*:* *: :* * ... : * :. ::* **. * *:::*: ***:************::** **::***::******::*** *:****** ************ :*********:*:**:* :*: *** ***:** :*** *..:.. *** * : : ****::: . *::*.*:*:********.:***** *:* : :* : ***.*** *********:* **:*** ::* **:** :** :*:** **:::: **:*** :*: :: :.:: .:**: ** :: ** ******: ******** *****::*******************.*********:**** .. :: *..:*:***** * ******:***:**:***: *****.. .*:... * . ::**.******* **::** *:*:***********:*:**:*.*:*:***:**:.**.: **: *:..*::** *:: *::: : . *: . :::: .:* .. : *::. . :* : . .: .:**::*. **********:** .***************:*******:**.. *:**.*******:* :*:**::*:**:**:*::***** **** ..:: . * *: **.:*:*:* * :.*:..: : . ::*:*:*.****.** *.***:*:**:*: .***:* :********** :*::** :*::***:.*********.** .: : .:***.::..: *: . .. :******.******** *****: **.**:********::* :**:****:.**:*.***: .* ***: ** ** :.*:.*::**:***:* : :::****:***:*::**** :******** **********::*****:*: *.** : **:*****:** :. :.: . . .: ::::.: *. :*. ** :.. : * :**::* ***:*: :. . : : ** . ** . * : *.:** :: . . . * ** :. *:. * : **::**:* ..**::** *:. * . * *::*:*********..:******.::**:**:** **** **:* *:**:: ***** ***: .**:::*****:****** *:*:*:** . ", "identical_positions": 921, "similar_positions": 418, "identity": "46.37%" }, { "cls_id": "homologset.agr.HGNC:16637", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z2G9-1", "uniprot_id": "HTAI2_MOUSE", "id": "Q9Z2G9-1", "name": "Protein HTATIP2", "aln": "MADKEALPKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYKNVNQEVVDFEKLDVYASAFQGHDVGFCCLGTTRSKAG-AEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRP-----------GEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPSSGQMELLENKAILHLGKDRDVPKL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B0BNF8-1", "uniprot_id": "HTAI2_RAT", "id": "B0BNF8-1", "name": "Protein HTATIP2", "aln": "MADKETLLKLREDFKMQNKSVFILGASGETGKVLLKEILGQNLFSKVTLIGRRKLTFEEEAYNNVNQEVVDFEKLDEYAPAFQGHDVGFCCLGTTRRKAG-ADGFVRVDRDYVLKSAELAKAGGCKHFNLLSSRGADKSSSFLYLQVKGEVEAKVEELKFDRLSVFRPGVLLCDRQESRP-----------GEWLARKFFGSLPDSWASGYAVPVVTVVRAMLNNLVSPGSGQMELLENKAILHLGKDSDGPKL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BUP3-1", "uniprot_id": "HTAI2_HUMAN", "id": "Q9BUP3-1", "name": "Protein HTATIP2", "aln": "MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAG-AEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRP-----------GEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P40008-1", "uniprot_id": "FMP52_YEAST", "id": "P40008-1", "name": "Protein FMP52, mitochondrial", "aln": "---------------MNG---LVLGATGLCGGGFLRHAQEAPQFSKVYAILRRELPFPATD-KVVAIVERDNSKWSQLITNEMNPQVLFTALATTRAAAGGLDKQYKIDHDLNLQLAQAAKEKGCETIVLVSSAGAHPDSRFGYMKMKGEIERDVIALDFKHIIILRPGPLLGERTNSKQSGFGGNLTAALGTRVYRSRFQRLLGYPVYGDEVGKVGVHLALN----TSGKDKVQFVSSKDILDISASLEKIAT", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:. ::***:* * :*:. **** * **:*.* : * * .* . . . :* * .*.*** ** : ::*:* *: *: ** **: : *:** **. .* * *:::***:* .* *.*.: ::*** ** :* :*: * : *. * * . . * * * * *: . . :::::..* * .:. ", "identical_positions": 68, "similar_positions": 59, "identity": "26.77%" }, { "cls_id": "homologset.agr.HGNC:16638", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7FND9-1", "uniprot_id": "F7FND9_RAT", "id": "F7FND9-1", "name": "Serine/arginine repetitive matrix protein 1", "aln": "MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKSPELPEPSVRMK-DSSVQEATSTSDILKAPKPEPVPEP-KEPSPEKNSKKEKEK--TRPRS-RSRSKSRSRTRSRSPSH-TRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR-TSSPPRKTRRLSPSASPPRRRHR-PSSPATPPPKTRHSPTPQQSNRARKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKR----SHVKNGEVGRRRRHSPS----RSASPSPRKRQKETSPRMQMGKRWQSPVTKSSRRRRSPSPPPARRRRSPSP---------APPPPPPPPP-RRRRSPTPPPRRRTPSPPPRRR---SPSPRR---YSPPIQ-----RRYSPSPPPKRRT--------ASPPPPPKRRASPSPPPKRRVSHSPPPKQR---SPPVTKRRSPSLSSKHRKGSSPGRSTREARSPQ------PNKRHSP----SPRPRAPQTSS-PPPVRRG-------------ASASPQGRQ--------------SPSPSTRPIRRVSRTPEPKKIKK-----------------------AASPSPQSVRRVSSSRSVSGSPEPTAKKPPAPPSPVQSQSPSTNWSPAAPAKKAKSPTPSPSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAVATPAPAAPAAVSAAATPSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q52KI8-1", "uniprot_id": "SRRM1_MOUSE", "id": "Q52KI8-1", "name": "Serine/arginine repetitive matrix protein 1", "aln": "MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASLKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKSPELPEPSVRMK-DSSVQEATSTSDILKAPKPEPVPEP-KEPSPEKNSKKEKEK--TRPRS-RSRSKSRSRTRSRSPSH-TRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPGRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR-TSSPPRKTRRLSPSASPPRRRHR-PSSPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDERPKR----SHVKNGEVGRRRRHSPS----RSASPSPRKRQKETSPRMQMGKRWQSPVTKSSRRRRSPSPPPARRRRSPSP---------APPPPPPPPPPRRRRSPTPPPRRRTPSPPPRRR---SPSPRR---YSPPIQ-----RRYSPSPPPKRRT--------ASPPPPPKRRASPSPPPKRRVSHSPPPKQR---SPTVTKRRSPSLSSKHRKGSSPGRSTREARSPQ------PNKRHSP----SPRPRAPQTSS-PPPVRRG-------------ASASPQGRQ--------------SPSPSTRPIRRVSRTPEPKKIKKTAMATQRNIRRVSKSPKADSLSRAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPAKKAKSPTPSLSPARNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVTIATPATAAPAAVSAATTTSAQEEPAAAPEPRKETESEAEDDNLDDLERHLREKALRSMRKAQVSPQS--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IYB3-1", "uniprot_id": "SRRM1_HUMAN", "id": "Q8IYB3-1", "name": "Serine/arginine repetitive matrix protein 1", "aln": "MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVK-EPSVQEATSTSDILKVPKPEPIPEP-KEPSPEKNSKKEKEKEKTRPRS-RSRSKSRSRTRSRSPSH-TRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR-TSSPPRKTRRLSPSASPPRRRHR-PSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKR----SHVKNGEVGRRRRHSPS----RSASPSPRKRQKETSPR--------------GRRRRSPSPPPTRRRRSPSP---------APPP-------RRRRTPTPPPRRRTPSPPPRRR---SPSPRR---YSPPIQ-----RRYSPSPPPKRRT--------ASPPPPPKRRASPSPPPKRRVSHSPPPKQR---SSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQ------PNKRHSP----SPRPRAPQTSSSPPPVRRG-------------ASSSPQRRQ--------------SPSPSTRPIRRVSRTPEPKKIKK-----------------------AASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAED-NLDDLEKHLREKALRSMRKAQVSPQS--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F1X7-1", "uniprot_id": "E7F1X7_DANRE", "id": "E7F1X7-1", "name": "Serine/arginine repetitive matrix protein 1", "aln": "MDAGFFRGTSAEQDNRFSNKHKKLLKQLKFAECLEKKVDMTKVNLEVIKPWITQRVTEILGFEDDVVIEFVFNQLEE-KNPDGKMMQINLTGFLNGKNAREFMKDLWPLLLSAQENIAGIPSAFLEQKKEEIKQRQIEQEKLASLKKVDED--KREKENKE-----RAQSKSPKRRKSRSPVKRDRKSSPSRSRSPRRKISP----AASPPSSPPNHKEEPKREPDQSESSKPEPLIQEASSTSDLVTEMKPDSVSEPVKESSPDKTSKSEDRP-KPRDRE-KDGRKDRPRHRSRSRS--PRSRRRPRSRSRSFSPRRRTSPRRRISPRRRSPPRRQPPS-RHRRSRSPVRRRR------SRSRSSSGSSSSRSPHKRAGKRGSATPPRKLARRTDLSSPPRRRGRSPSGPDTSPSAGKHRPG----------------GRN-------------DSRSPSPKPRRSDASDSEEDKLGKGSTADSVQQRRQYRRQNQQSSSDTGSSSSSEDEGPRRQNRGAGARNGEIRRRRSHSPASPRRRHRDASPRKRRSPSPPGRRHRSQ------SPVRRRRSPSPPPRRRSPSPPPRRFTPPIQRRYSPPSPSPAQKRRSSGSPPKRRRSPSPMPKRRIPPSPPPKRRMSPSPPPK-----RRKSPSPMSKRRTSPSVSKRRTSPSPVAKHRRSPSPMSKRRTCASPVSKRRNSPSPAPQRRSSPSPMPKHRGSPSPVTKRHTSRSPKRSRGTSPGKRRTPPSSASPPPRHRRNSPNPPAAQRGRDTRSSPPAHTTRVSSSPPGRYGASGSSPQRQRRQTSPSHSTRPIRRVSRTPEPRKSQR------------------------GSQSPPPERRQ-VSRSPSASPPPAQKRPAS-----VSPSRSTSRSPPPPAKKNSSVSPSPSPNKNSDAEGG-KKKKKKKEKKHKKDKKHKKHKKQKKEKGGEEK----------SGGATGGHGPEAEPDSDQKKESESEVED-SLDDLEKHLREKALRSMRKAQMSPSSQS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VU43-1", "uniprot_id": "Q9VU43_DROME", "id": "Q9VU43-1", "name": "Serine/arginine repetitive matrix protein 1", "aln": "---MMFTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEFVYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEILKREEEQRQRDRSRSRSRSRSQRDSSRRDRQRD-RSKSKSRSRSRSMKPANNNGSVPSAAREAAANAAAKIRKRGSSSAARPGSRERRSSRRPRSRSRSRSRTAGKKTGSVEPAPAKTVNGRHSTDKSSPVPPASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSRRSRRRGRSSSISLSPERNQDQFEHRRNKNSVQNKRQYRNNRGDSASS-MERGNDRGRQFGGGGGGRRGGRRFSPRGRSPMRQDNGGGNGGNRFQRSNSRRRSRSR---RLSRSPMRYSRSPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRGGSPNFRGGGRIHWQARHSPGGGGRGGGGGMGRFDRRQSPQQNRYNRDHRQSPMQQNQPFR----KQFSPHQGPGRRFSSPQQRRNSRDRRPNSRERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGRQQRQR---------SASPPEKRRSSHSRSRSLSRNRSRSRSSSQHSRKRESPIGRSSVEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAVRSSYASLSRTPSPFLKPHERLAAAKAAAAASAAVPKKSRDQSQSSSSDSSAESDDSEEQPRRKKQ-----PTNMETSKGKKEKVRRSSESSTSSEQSDDE-------------DNSSGDERLKKKLQQ--------RKSKEAAALKGKEKEHEKEKDKR--------------------------RSDKKSKRGAISSGDEESTSSRKRGHKKTRRDEAGDNSDSEDEHVPKKKRKKAKKPADSSDSDSEASSKRKKHKKHKKHSKKSKKHKKHKRKCSAGKSRADSSSQGSSDEDEQLPHSVAAKRNGNAGKLALLLPGASGAGVINEDLEKQLRERALKSMKKLD-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* **. :**.***:*.***:**:**.:**:*:***:**:*:*::***::::*:** :*****:**::**** * * * ****:******:***:** :**.*******. :***: *:: **:** :*: **.: :. ... :*:...:: * :*:* * :* .* . . . . . : : ..: . .::... . * : . ::: *.. . ... * ..:.. .* *. :. :. . **** * *.*** ** * * **.*. . .: :. :* * : * .* . . . .. .. ** :. * . * * * * * .* : * ** . ** : ::... . ... * : *:. **. : . .:. :: . . * .*.. . . *..*. :.* *.***.* .. . .* : * . * *: *. : * ** : : * * . . * .* : .. .. :*** * : :. :. : . * .. .... . . .* : * : .:. . * ..*. . .:* * * .: .:: .: * .* :: * :* * . . *. . : . . .:. . *: .: .*: *. :*: .. **:**:*.:.:*..*::*:::* . *. : : . . :. . :***::***:**:**:* : ", "identical_positions": 196, "similar_positions": 266, "identity": "18.96%" }, { "cls_id": "homologset.agr.HGNC:16639", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A2Y2-1", "uniprot_id": "A0A8I6A2Y2_RAT", "id": "A0A8I6A2Y2-1", "name": "", "aln": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRG--ERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPVVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQTAPEPPKPYSLVRETSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE---SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKIHTTSLTGQSPPLASGHQGEVDAPS-EPGATNIQQPSSPDPSTKQSSSPYEDKDK--KEKSAVRPSPSPERSSTGPELPAPTPLLVEQHGDSPRPLAAIPSSQEPVNPSSEASPTRGCSPPKSPEKPPQSSSSESCPPSPQPTKLSRHASSSPESLKPTPAPGSRREISSSPTSKNRSHGRAKRDKSHSHTPSHRAGRSRSPATK-RGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGKSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPTRRRSRTRSPVRRRSRSRSQARRSGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSHVSSRRSRSLSSPRSKAKS---LRRSLSGSSPCPKQKSQTPTRRSRSGSSPPKQKSKTPPRQSRSNS--------------------PQPKVKSGTPPRSGSVTNMQAEECSTTPQRQSHSESSPDGEVKSRTPSRQSCSGSSP-RVKSSTPPRQSPSRSSSPQPKVKAVISPRRRSHSSSSSPSPSRVTSRTPQRKSRSVSPCPKVDSRL-LRHSRSRSSSPDTKMELGTPLRHSHSGSTSPYPKSMLQTPPDQNLSGSKSPCPQ-KSRDSPTGSS-GSFSLCPGVTPSSILPGESSFSSSFVQQKGQSQTWP----DTSSPEVRQMHLESPSLQSKSQTSPKGGLSRSSSPVTELTARSPVKQDKSELSTDPKLKSGMSPEQNKTKPDSSLYPLVDSKSLLVQSRLEPSELKERLGLIEEDVASSCVLR--DKFS--PTQDRPESSTVLKDTPRVLLKERSGAGSPPGTRDQKILLPNSSQDE--LMEVEKSEQPLSQVLPTLSPEHKEMSASNFESSPEIEESPAVLSTLDQSQSQPS-KAAEIPAVASCWVGPQVSPEHKELSHSPPRDNSFES-LEFRNSGPV-LEVNTDFSPEVKEELNGPFLNQTETDPSLDMKEQSTRSSRRSSSELSPEIVEKVGIFSSQSVSSPLLETVQQRTPSRERSSSVSSPELKDGLPRTPSRRSRSGSSPRLRDGSGTPSRHSLSGSSPGIKETPQTPSRGRSECDSSPEPKALPQTPRARSHSPSSPERNNKSVTPQRERSGSESSVEQKTLTRTSPGQRSRSGSSQELDGKPSVSPQERSESDSSPDSKPKARTPLRQRSHSGSSPEVDSKSRHSPRLSRSGSSPEMKEKSRVLQRAQSGTDSSPEHKIPAPRALPRRSRSGSSSKERGPSPEGSSSSESSPEHPPKSRTARRGSRSSVEPKTKSRTPPRRRSSRSSPELTRKARVSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPTEKSRSSRRRRSVSSPRNKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPTRQESSRTSSRRRRGRSRTPLTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRS---VNRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRSPPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRAARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALSSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSARTPMSVLQQTGGSMMDGPGPRIPDHPRSSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTSAIPASVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPAASAVNLAGARTPAALAALSLTGSGTPPTAGNYPSSSRTPQAPTPAN-LVGPRSAHGTAPVNIAGSRTPAALAPTNLSSSRMAPALSGANLTSPRVPLSAYERVSGRTSPLLLDRARSRTPPSAPSQSRMTSERERAPSPASRMVQAPSQSLLPPAQDRPRSPVPSAFSDQSRS-IAQTTPVAGSQSLSSGTVAKSTSSASDHNGMLSGPAPGVSHAEGGEPHASTGAQQPSALAVLQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPTPVPKEAVREGRPQEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRQPSPQPSPRDQQSS--ERVSWRGQRGDSHSPGHKRRKETPSPRSNRHRSSRSP-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BTI8-1", "uniprot_id": "SRRM2_MOUSE", "id": "Q8BTI8-1", "name": "Serine/arginine repetitive matrix protein 2", "aln": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRG--ERPDYKGEEELRHLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGAKEETPGQRPVVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQIAPEPPKPYSLVRETSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE---SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKIHTTALTGQSPPLASGHQGEGDAPSVEPGATNIQQPSSPAPSTKQSSSPYEDKDK--KEKSAVRPSPSPERSSTGPELPAPTPLLVEQHVDSPRPLAAIPSSQEPVNPSSEASPTRGCSPPKSPEKPPQSTSSESCPPSPQPTKGSRHASSSPESLKPTPAPGSRREISSSPTSKNRSHGRAKRDKSHSHTPSHRAGRSRSPATK-RGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGKSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSQARRSGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRSARSRSRTPARRGRSRSRTPARRRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSHVSSRRSRSLSSPRSKAKS---LRRSLSGSSPCPKQKSQTPTRRSRSGSSPPKQKSKTPPRQSRSNS--------------------PQPKVKSGTPPRPGSVTNMQADECTATPQRQSHSESSPDGEVKSRTPSRQSCSGSSP-RVKSSTPPRQSPSRSSSPQPKVKTVISPRGRSHSSSSSPSPSRVTSRTPQRKSRSISPCPKVDSR--LRHSRSRSSSPDSKMELGTPLR--HSGSTSPYLKSMLQTPPDQNLSGSKSPCPQ-KSRDSPTGSS-GSFHLCPGVTPSSIVPGESCFSASFVQQKGHTQTWP----DTSSPEVMQTQVESPLLQSKSQTSPKGSLSRSSSPVTELTARSPVKQDKSEISTDPKLKSGMSPEQSKTKPDSSIYPLVDSKSFLVQSRLEPSELKERLGLIQEDVASSCIPR--DKFS--PTQDRPESSTVLKVTPRVLLKERSGAGSPPGKRDQKSLLPNSSQDE--LMEVEKSEQPLSQVLPSLSPEHKEMPGSNIESSPEVEERPAVLSALDQSQSQPS-KAAETPAVASCWSGPQVSPEHKELSHSPPRENSFESSLEFKNSGPV-SEVNTGFSPEVKEELNGSFLNQTEADPSVDMKEQS-RSSRRSSSELSPEVVEKVGLFSSQKVSSPVLETVQQRTPSRERSSSAS-PELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDTPQTPSRGRSECDSSPEPKALPQTPRARSHSPSSPERNNKSVTPQRERSGSESSVEQKNLARTSPGQRSRSGSSQELDGKPSASPQERSESDSSPDSKPKTRTPLRQRSHSGSSPEVDSKSRHSPRLSRSGSSPEMKDKPRVLQRAQSGTDSSPEHKIPAPRALPRHSRSGSSSKERGPSPEGSSSSESSPEHAPKSRTARRGSRSSIEPKTKSHTPPRRRSSRSSPELTRKARVSRRSRSASSSPEIRSRTPPRRRRSPSVSSPEPTEKSRSSRRRRSVSSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPTRQESSRTSSRRRRGRSRTPLTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRS---VNRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTP-TRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRAARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALSSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSARTPMSVLQQTGGSMMDGPGPRIPDHPRSSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTSAIPASVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPAASAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPTPANLVVGPRSAHGTAPVNIAGSRTPAGLAPTNLSSSRMAPALSGANLTSPRVPLSAYDRVSGRTSPLMLDRARSRTPPSAPSQSRMTSERERAPSPASRMVQASSQSLLPPAQDRPRSPVPSAFSDQSRS-VVQTTPVAGSQSLSSGTVAKSTSSASDHNGMLSGPAPGISHAEGGEPPASTGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPTPVPKEAIREGRPQEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRQPSPQPSPRDLQSS--ERVSWRGQRGDSHSPGHKR-KETPSPRSNRHRSSRSP-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UQ35-1", "uniprot_id": "SRRM2_HUMAN", "id": "Q9UQ35-1", "name": "Serine/arginine repetitive matrix protein 2", "aln": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRG--ERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE---SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARR-GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVK-SSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVP-RTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASAN-LVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSER--APSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QLP6-1", "uniprot_id": "F1QLP6_DANRE", "id": "F1QLP6-1", "name": "", "aln": "MYNGIGLTTPRGSGTNGYVQRNLSSIRVKRNRDERGGERDEKDKERLESQLNRQPNADILEHQRKRQLEVKCAELQDMMEEQGYSAEEIEEKVNTFRLMLQERQE----PAPPPTEKTAVTETHALAAANQQKNDRLRQAFGISSDYVDGSSFNPDRKEREKEKREQE-----------------RLEREKQQQQQYQIIESDDSDSSTEPKKSRKKKKKKNK---SRESSESPSPSPHREKKKDKKKKKKREESVNSDTES------SSSDEKETSKGKRKRS------------------------------------------------------------------------------------------------------------------------DNEAPPPSKSRRRQSASSSPARSQSPQRGKQQKKTDSRPEEVRKGRSPDRRR------------------------------------------RGRSQESPKRMEIRERSPRRSRTPEQNKRYKGREREREQLQEKPQR----------------------------------------KRNDSSSRSPPPKQQLDRRPR------------SEEREKPPQTRRHDSSSPSPPPNKQRQDRRQRSEERLKAPLRKRPDSSPRSPSPK----------------------------------------------------QQRDRRDDGKKNKVQSRHDSSSSSSTSSPSPSPSPRKDRMRRGHSGEKARAPS-----------------------------------------------------------------------------------------------------------------------------------------PRDREKERARGGERISDRDKSRKEDRGRDGDKAKEQARNRSSDSVSPK-----------------------------------------------------------------------------------------------------------------------------------------------------------RSPFANGR-------------------------------------------------------------------------------------QKERELEKERQEQRDREKRREE------------------------------------------------------------------------------------------------------------------------------------------------EMREEALRKARESD---------------------------------REKERNRSRREEVSHSDRTSSSRCQPENRRGIRGSEAEQEVLKKDRRMEEDKRQEKSPPHQKMEKLAQKEKTGQKDKAKAVSSSSSSSSSSSSSNSESDSDSSSSSSS-------SSSSSSSSSSSSDDDKKKKQSSKDSTSASKSVPNAVIAQAIARREKENRVRNGESDEGRKTYPPIQRQSSPPEPQSKRDDVEKKQRDPERERRPGQSSSSFTVMNDRERGKER---YTPTETSSPPLSPPQRVLDRAAQVGERYMPSGESQSQSRGRGGERYSPSELEQESSRPSPSRGRDRQSDQRKEAPPLSPREKGR-IDAPQVKQAASRPSPKRTPPRQYQDPQRSLSPSP------------RRGVRRLSPPRNYSPSRRDRSRERLRERDRFRAR----------------------PADRDRERSRERRTRNSRSRSPRRPSPPYRSRRSPSPARRRRS-------SRSLSREREREQERRRNRE-------RDRQREQEREKEREQRTRVPPKDLTPPRRSPSSSSSSSSSSSPSPQRPMRGVKPTDTDKDRSREANEQARNKQPERTS--------------------KHRSPSSPRESRLSLPLSYR---------------------DVPARSKSPTSTDPPGGRLRRQSPTSVHEPSARGKTAVNGKSEKESSGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQKRSSSSSSSSSSSSSSSSSSSSSSDSSDSEAEKEKAG--------------------------------------------------VKASTNKNAGKTAKGRASSSSSSSESEKEKKTKSPPRP-----------------------KRVPADSLRDSRSLSYSPPARQRRPAHSPPSRRVAS---------RKSRSRSPDSRRRK---------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A8JNI2-1", "uniprot_id": "A8JNI2_DROME", "id": "A8JNI2-1", "name": "", "aln": "MYNGIGLTTPRGSGTNGHVQRNWACVRPGKK---DKDYRAEDDTKKLDAQLNRPPNKEILDHDRKRKIEVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTATASAATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTGEPASSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKTRRPAVSKRTHPDCACACQQKDPEPALEPAHRTAEHSIQKELPS--------------------------------------------------------SQMKINIDGSVLLELLKYSSSSLLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSVALQKELDAQRE-------------------------------SLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKKKRKKRARESSASPERKK-------------------------KKKSKKHKKESKSKKKRSRKRKHSESGRDSDRDSDEEDDSSEEERRESKNVRKKAKKDKKKRDKKLKKKSRARASSSDSERTNSPSRKEN----------------------------------------KSDRSRGAKASKSDEKAPQQENVMRSRSRERKDTRSSRPLEASIDSRQRKPRERSAATPPRKE--------------------------------------------------------------------------------------------------------------------------------------PERHRERSKDRQRSKEKHRSRDRLRSRERQRSRERQRSRERQRSKERQRSKER---------------------------------------------------------------------------------------------------------------------------------------------------------QRSIERQRS-----------------------------------------------------------------------------------KERQRSKERQRSRSKDALRCKEK---------------------------------------------------------------------------------------------------------------------------------------------PQCNEKERSRERRRSKSKD-----------------------------RQRSKEKHRPKDEQQSVDKRRDRSTDRSKENQRSNERQRSKERQRSKERERSKDRQRSRERRRSKEGQLSKDRQGLKERQRSNERKRSKERQPSKEKQRSRERQRSREPLQSKDRQRSKERQRSRERPAKEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRNARFKSPAHSPEAPPKKSVPTPAFNPFKAAEDTVN-DILGTKSVMVALEQTKRQRAASSSSSDSDSSGSSSTSSRTPSPKPTPRKQKKRSKTPELKEVKKEISPRKESRVSVK--REQSNSPQKSKSKSKVDESSPKRTSRRSRSISSELRYSPAERHPERYHDIVQDKKRPSKVREAHSTKPAPVVRLRAQSDDGSDAETGVDGAALEEFQQSRREREEQQELRMLEQLKSGIAAKAKQKIKIMEKDPAKEGSEVSGSDQVTATKRNSLSEFLVANNVTALINTLTTTTVTLTTTPPPPLAVVVPLEQRQEQPQQRDPD-------RELSVPVEDTVKKRDTSTPPICKTPQVTANGDAKSPTLVHKNHVHHNRPPPQHMHHHSQQQQHHQHPPGKRIFHNRTLNNNPNSRHSTNNPHACGGGGVPHSNSNSSNSGGNNNNAAMLPFLAGTPGTYNRTTNRLNHGPLLTATHYNICKNHQHSLQQQQAHHLARGLVYNSALFGHGQRHPGLLSLTGAG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGMSGPGAPLLGHPSHVRGGGGPISFNAAAAAAAVAANSISYLHHHHQHQQKPKIVIKPFKIHDPQPLVAALADSSLVDAIVSKVSTATVAAAESAARRSRSR--------------------------------------------------------------------------------------------------------------------------------ERRSRSKRRTSTSHHRHDSSSESRSRYSSSSSRSGSHSSR------------------------------------------------------SGSHSSRTSCSTNSSSGSSSSGSGSGSSQSGSRSPSIP-----------------------RRRGSPSFLDRRRITSARKRPIPYHHKANAEGEVED----------ASSCCSSCFSRASSPATPLLTPLRNSRSPSMAAF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*******.*********:**** : :* : . : *.: .:*:: * : ** :**:*:***::*::* **::::*:** ::*:.:* :** * : ..*.* * . . . : : . .. :: *: .: . . : : : .: . *.. :: .. :. .. . . . :. * * .. :: . :. :. .:. . .... . * ... : .. .:. . :* .:.: . ** ..: : .. . :: . :* :: . :. . :. . ... .. .* : . .:.:. : ..: :: . ..:*: : .: .. .:. :** . . .* * .* * *. . . .. : : * : :. . . .: .: * . . : .. . : * ::*. . ::: : :*.: . .. *.:. . * . * :. . . . . . . : * . : . : :. . . *. .. . . . * .. : . * . .:.: . . . . .. . :: . . * . * * : . . : . ..* ... :. :*:. :* * : .: : :.. * . * .:: . *:. . : . .. *. . . : ..* : :.. *..* . :. ... :.. * . . .: * .. . . :.: : : . .: ::*. . *. . .: * . : : . :. : . :. .** * . .* : : :: :: : . ..: .::*:*:* .***.* * ****. *.* :. : :. .: .: .. .****.*....... : **. * * *: * * :: : :. . . . . *. * ", "identical_positions": 128, "similar_positions": 395, "identity": "4.62%" }, { "cls_id": "homologset.agr.HGNC:1664", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P97943-1", "uniprot_id": "SCRB1_RAT", "id": "P97943-1", "name": "Scavenger receptor class B member 1", "aln": "--------------------------------------------------------------------MGVSSRARWVALGLGVLGLLCAALGVIMILMVPSLIKQQVLKNVRIDP-SSLSFGMWKEIPVPFYLSVYFFEVVNPSEVLNGQ--KPVVRERGPYVYREFRQKVNITFNDND-TVSYIENRSLRFQPDRSQGSE--SDYIVLPNILVLG--GAVMMEDKPTSLKLLMTLGLVTMGQRAFMNRTVGEILWG-YEDPFVN-------FLSKYFPDMFP-----IKGKFGLFVGMNDSS--SGVFTVFTGVQN---------------FSKIHLVDKWNGLSEVNYWHSEQCNMIN-GTAGQMWAPF-MTPESSLEFFSPEACRSMKLTYQES-RVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCR-------ESGIQNVSTCRFG-APLFLSQPHFYNADPVLSEAVLGLNP-DPKEHSLFLDIHPVTGIPMN-CSVKMQLSLYIKSVKGVGQTGKIE-PVVLPLLWFEQSGMMGGKTLNTFYTQLVLMPQVLHYAQYV-LLGLGGLLLLVPIIYQLRSQE-----------KCFLFWSG-----------------------SKKGSQDKEAMQAYSESLMSPAAKGTVLQEAKL------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61009-1", "uniprot_id": "SCRB1_MOUSE", "id": "Q61009-1", "name": "Scavenger receptor class B member 1", "aln": "--------------------------------------------------------------------MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDP-SSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQ--KPVVRERGPYVYREFRQKVNITFNDND-TVSFVENRSLHFQPDKSHGSE--SDYIVLPNILVLG--GSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWG-YDDPFVH-------FLNTYLPDMLP-----IKGKFGLFVGMNNSN--SGVFTVFTGVQN---------------FSRIHLVDKWNGLSKIDYWHSEQCNMIN-GTSGQMWAPF-MTPESSLEFFSPEACRSMKLTYNES-RVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCR-------ESGIQNVSTCRFG-APLFLSHPHFYNADPVLSEAVLGLNP-NPKEHSLFLDIHPVTGIPMN-CSVKMQLSLYIKSVKGIGQTGKIE-PVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYV-LLGLGGLLLLVPIICQLRSQE-----------KCFLFWSG-----------------------SKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WTV0-1", "uniprot_id": "SCRB1_HUMAN", "id": "Q8WTV0-1", "name": "Scavenger receptor class B member 1", "aln": "--------------------------------------------------------------------MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDP-SSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGE--KPQVRERGPYVYREFRHKSNITFNNND-TVSFLEYRTFQFQPSKSHGSE--SDYIVMPNILVLG--AAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWG-YKDPLVN-------LINKYFPGMFP-----FKDKFGLFAELNNSD--SGLFTVFTGVQN---------------ISRIHLVDKWNGLSKVDFWHSDQCNMIN-GTSGQMWPPF-MTPESSLEFYSPEACRSMKLMYKES-GVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCL-------ESGIQNVSTCRFS-APLFLSHPHFLNADPVLAEAVTGLHP-NQEAHSLFLDIHPVTGIPMN-CSVKLQLSLYMKSVAGIGQTGKIE-PVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYV-LLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z8R4-1", "uniprot_id": "A0A8M6Z8R4_DANRE", "id": "A0A8M6Z8R4-1", "name": "Scavenger receptor class B member 1", "aln": "--------------------------------------------------------------------MVSQTTVSIVFLVLGGMALLF---GTVLVFVGPIIIDDQIVKNVEINPKNDLSYTMWKDIPVPFFMSVYFFHIVNPDEILKGE--RPMVIQRGPYVYRENRWKDNITFHENH-TVSYKEYRQYFFEESMSVGDE--SDVVTIPNMLVLG--ASVMMENMPFPVRLLLSTTFKTFNEGPFLTKPVGELMWG-YDSKLVD-------FLNKYLPGMLP-----SSGKFGLFADFNNSN--TGLFTIFTGRDD---------------IRKVHMVDSWNGLKNVDYWRSDQCNMIN-GTAGQMWPPF-MTKETTMPFYSPDACRSMELVYQRP-LVSSGIPVYRYVSPKTLFANGADFPPNEGFCPCR-------QSGLLNVSSCRHG-SPTFISQPHFYNADPQLLDTVSGLSP-SEDEHGLFIDIHPETGVPVN-VSVRLQLNLFLKKVSGISETGNIA-EVVMPMLWFEESGYIDGPVLHTFRTNLVVLPKVMEYMQYI-FIALGLAAILTAVILFLTDKK---------------VWKK-----------------------SSQTLTQAVSTRVYDNVNHSKQHPANETQAEKYNQSNTGKK----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8INY3-1", "uniprot_id": "Q8INY3_DROME", "id": "Q8INY3-1", "name": "", "aln": "-------------------------------------------------------------------MCCSCCGVTQQKAWVFGLGTFFAVSGLLAIICWPGFIDSGIMKALPLTP-TSKTFEKWEELPIPVYVYMYLWNWTNAADVQANG-VKPIFAQLGPYVYREERKKMDLEWHDNG-TVTFNPRRTWFWEEELSGGKQ--TDLITAPHLPSLA--ASNQMRNSNVFLKFMFNEALNANGGHLFVTHTAAEWLFESFYDEFLH-------YAMTLNNPLVPK---IESDHFAWFLNRNGSKDFEGPFTVHTGVGD---------------IKEMGEIKYWKGQNHTGWYDG-ECGRLN-GSTTDLFVPD-EPKEKALTIFIPDTCRIINLEFTGQSETIQGITGWKYEITPNTFDNGQINGNAKCWCPLERQPDNCPATGATDLGPCADG-VPMYLSADHFMYADESYGSTISGYNP-NYDQNNFYIIMERKMGVPLK-VNANVMITLYIEPDSVIDILKGLP-SFYAPLFTTASRAEID-EALASELRLALNLPAIGRYTGVG-FLCLGCILIAVGILLTIKRKWYGQAE-------------------------------------LDKLALKDNEETPYEPEVPANVVERNF------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJA7-1", "uniprot_id": "Q9VJA7_DROME", "id": "Q9VJA7-1", "name": "Protein croquemort", "aln": "-------------------------------------------------------------------MRCGCCSVRQQKIWVFSMGGLILAIGIFLASAWPAVSRQWIRSLLPLAP-NSFIYNRWVTTPTPVYSTVFLFNWTNPGDLNTEG-VKPHFEQLGPYTFSDFKVKEDLEWNQP--QVTYFGKRTWHFLPEKSNGSL--DDVVIAPHFPTLT--AALYSRRLRRILRKVMNFTLNREGGATHMTHTAGQWLFDGYYDHLLD-------FVEQLHSPLLP----VYDNTFGWFYERNNSKTAEGNFTLHTGRGD---------------LSQLGDLLLWNGENTTGFYPG-ECGKVN-GSTGELWSPY-RTWDQPTTIFLPDAARYLNL-FPKENLTIDGIDVWRYESTNLTIDNGQLSPDTECFCLKNRE---CPRNGVLDYGPPAFN-GPFYMSHPHFFLTDQMYRENTTGLQP-EESEHGMYVIMEPTLGIPLS-LRGQLMISTKVVRDEAIDLFKNVAYDHYAPLFTMRLHAELD-EGLTKLLKLALNAAIIGMYTGIG-LVLLGMSIVVTGIFITKKHKWHSEQR-------------------------------------PDKHLQCTQN-----------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q27367-1", "uniprot_id": "CRQ_DROME", "id": "Q27367-1", "name": "Protein croquemort", "aln": "-------------------------------------------------------------------MCCKCCGETQRKVWVFGLGSVFLLLGILIVVFWPGIADNLVEDGLTLKP-GTDAYESWLEAPIPIYLSFYMFNWTNPEDIRNPD-IKPNFVEMGPYTFLEKHKKENYTFYDNA-TVAYYERRTWFFDPERSNGTL--DDMVTAAHAITAT--VADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEGYQDNITD-------FLNLFNTTKID----IPYKRFGWLADRNESLTYDGLFTIHTGTDD---------------ISNLGRLTHWNGKSETGFYEM-PCGIVN-GTTGDMFPPK-MNVNDEITIFATDACRFMNL-RPRGTYENHGLTATKWVGTEETLDSGENYPNQACFCDEARFD-ECPKTGVVECKACRDK-APIYSSFPHFYLADQSYVDAVSGMKP-EKEKHEFFLAVEPITGVPVQ-VHGRIQINMMIEPDDDFDIYRGVQ-KVLMPMFWFDQYAELS-SELASKAKLAINLSSYGIIFGYS-MIAFASVFLITGITLTVTKKWVRRTP-------------------------------------EDEDILTN-------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VM10-1", "uniprot_id": "Q9VM10_DROME", "id": "Q9VM10-1", "name": "", "aln": "---------------------------------------------------------------MPTQNSAMWGQKSNRKLIIGIFGFCLGLFGILCGMFWVDLFDWIMHKEMALAP-DTRVYENWKSPPIDLSLDIYLYNWTNPEDFGNLS-TKPILEQVGPYRFIERPDKVDIHWHPENASVTYRRRSLFYFDAAGSNGSL--DDEITTLNAVALS--AAATAKYWPPVKRSLVDVGLKMYGAEMSVQKSIDELLFTGYNDAMID-------VAMAMPIFGD-EV-KVPFDKFGWFYTRNGSADLTGVFNVFTGADQ---------------LAKLGQMHSWNYQENTGFFDS-YCGMTN-GSAGEFQPQH-LKPGDSVGLFTPDMCRTIPLDYVET-VDIEGLEGYKFSGGPRSVDNGTQYPENLCFCGG-----QCVPSGVMNISSCRFG-SPVFMSYPHFFNADPYYPDQVEGLSP-NQKDHEFYMVVQPSTGIPLE-VAARFQVNMLVEPIQGISLYTGIP-RIFFPLVWFEQKVRIT-PDMADQLKVLPIVMLSGHIFAGI-CLIVGITLLCWTPVQILLASCRNRRY-------------------------------------DLRTKTKTNGQYKSRSQFSSAEELKSKASTLVCEKSVKGSPDSSPLLEKGRKPTIIKSQTGESVATASTAISDNKQD----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "B7Z031-1", "uniprot_id": "PESTE_DROME", "id": "B7Z031-1", "name": "Protein peste", "aln": "---------------------------------------------------------------MTSR------TRHCARLGIVLLGICCIASGIYLFRNWIDMFTRMRGQEMALSP-NSRSFEGWKVSPLPLDFDIYLFNWTNPDDFYVGSNKKPHFEQLGPYRFREKPDKVDIEWHNHNASVSFHKKSWFYFDAAGSNGSL--WDKVTTVNSVAHS--AARRAAVD-WFARTGVNIANKLYRQGVTITKTVDEMLFKGYEHPFIS-------VGKLLRPQ------DVPYKRIGYHYPRNGSSEFDGDINMFTGADD---------------IAKMGQIHTWNNLTHTGAFEG-TCGQVH-GSMGEFFPPN-LGTKDTVYMYMPKMCRAIPLDYVET-VTVHGVTAYKFSGTRHAVDNGTLYPDTRCYCVGG----KCMPSGVINIGPCSFN-ASVYMSFPHFYMADPSYLEAIEGLRP-EREKHEFFMALEPNAGVPMD-VGGGFQANYYMEPIPGITLYENVP-TVMIPMMWCEERVRVS-EEIAADIALVPLIVLLGQIVTGI-LLAGGLICTCWYPTRQVTHFCHS----------------------------------------DPKAKASVLRPLNAFGVNSSAATAPVAQLFRNNISSSGNERVGVRLLDYNRDSGIRLESGTMESSHRERLISEDSPDVVVR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VLU7-1", "uniprot_id": "Q9VLU7_DROME", "id": "Q9VLU7-1", "name": "Protein peste", "aln": "------------------------------------------------------------------------MIGKQRIWQTSVLGLLLASFSLFSVLYMEQIERWMLEWFMVLRP-GTMISSLWQSPAMDINVDLYIFNWTNSEKFSDPT-VKPRFEELGPYRFTERMQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRP--TDPIVAPNLLIVG--LYQKMVMWSPMLRSLMLLALNIYGKEQAMIRPASDWMFDGFDTPMIK-------MSKMVPPSLVPEM-KFPYEKIGYAYPRNGSMEIYGHHNVYTGRDE---------------FQKLGQIARWRYNNVTEASP---RCKLK-GSAGEFHPIP-LVKGRPISYFLPDLCRELQVDYSGT-TIFEGIDAFVYRGSARNMANGTDNPDNSCYCQDNC---QEVRSGLLNISSCWYG-TPVFASYPHFFKADPYYGEQVEGMKP-DKDRHEMVIMLEPKTGMVLE-IKARIMANLLVEPKT-HLIYRTAR-RTFFPLIWADYNVRIT-DDLLVYVKLMPILEFVGKICGIL-GVVLGLLMVFWYPHQMIWQKSLMHKI-------------------------------------EISSIETNSSLEPVKNNDVEDSPLLKGLQYAAAKDGAGNGN----------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W0X0-1", "uniprot_id": "Q9W0X0_DROME", "id": "Q9W0X0-1", "name": "Scavenger receptor class B member 1", "aln": "----------------------------MQLDDILHINNCKADCSSLSTTPNPKTDLVNMNGPKHKFCTKLSSTYLRKWWITIVVAAALIIGGIVVACEFTVLIDAVVDRMVALRP-GAKTFGWWAKPPVEPRISLYIYNVTNADDFLSNG-SKAIVDEVGPYVYSETWEKVNIVENDNG-TLSYNLRKIYSFREDLSVGPE--DDVVIVPNIPMLS--ATSQSKHAARFLRLAMASIMDILKIKPFVQVSVGQLLWG-YEDPLLK-------LAKDVVPKEQK----LPYEEFGLLYGKNGTS--SDRVTVNTGVDD---------------IRRYGIIDNFNGRTHLPHWTTDACNTLA-GTDGSIFPPH-IDHDRILHVYDKDLCRLLPLVFEKEVMTSNEVPGYRFTPPEWVFADVDSHPDNMCFCPAGKP--SCSPNGLFNVSLCQYD-SPIMLSFPHFYLADESLRTQVEGISPPMKEKHQFFFDVQPKMGTTLR-VRARIQINLAVSQVFDIKQVANFP-DIIFPILWFEEGIDNLPDEVTDLMRFAEQVPPKIRVALIVGLCALGVILLLLSTFCLIRNSHR-----------------------------------------QSTLHLEGSNYLATAQVDMNKKQNKDNQPARY-------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A8JNI3-1", "uniprot_id": "A8JNI3_DROME", "id": "A8JNI3-1", "name": "", "aln": "MGLEKHYLRYGRTARDHLLDWATCGRGRRQQQQQQQQQTHAQPSQGSTATGRRSRPHVTHRGTPLSMLISNGVRISNNRLAVIIIGIITLILGIILSSMP--WLDYFILKNLRLWN-DTLSYHYWQRPGVIRLTKLYIYNVTNPDGFLRGE--KPHLQEVGPFVYREDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDK---DTPITTPNIPLLT--LTSLSPKLGYLLSKTISVVVTAAQFKPFINVTAEQLAFG-YDDALVS-------LAHRFYPKHMR-----PMERMGLLLGRNGTL--TEVSSVKTGMDS---------------MDQFGYIDQLNGLDHLPHWSEPPCTSIA-GSEGSFFPPRELTKSEVVHIYDKDLCRIIPLKYVES-LEKDGIAADLFRLPNNSYGDSAHNPENKCYDTSEYEP----IQGLQNISPCQYG-APVYISNPHFFESHPDLLNSVEGLKP-EREKHETYFKIQPKLGVPLE-GKVRIQLNLKVTRAKDVYPVRDFR-DFVFPVMWLEEGISELTPAIKRWIYLGTVIAPSAVPIGSYLMILGGAFAIIFSFVRAYQNFMFAQDP-------------------------------------TLEILEMGRRSLRRGSSFIAHQQHRLLVHHRDSYSLLRHGPMATCLGEGNREEDAQPIIDVSLSGGISQES----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VET1-1", "uniprot_id": "Q9VET1_DROME", "id": "Q9VET1-1", "name": "Scavenger receptor class B member 1", "aln": "-----------------------------------------------------------------MKLFTNKNQRNAKLLRSAALGMTLLFFGSLVIISDP--LQSILDTQLSLKP-GTLLHRLWLLPPLDVYINVYMFNYTNVDEFTSGRASKLQLQEVGPYVYKEVLSNHNVTYNESNNTITYSPKREYVFAPERSVGDPK-IDRIRAPNIPLMG--VTTLASSLSMFAALGLSAITRQLNSQPMLEMSVHDYMWG-YEDHLVE-------LASRFVPNWID------FSSFGIMEKLFREGNESNVFNMNLPEPKDKYGMRMTDAPRGYTVDSINGERGFKGWQYNEETNGTMCNRIW-GSHDATLFPLDMDENDEFFLYRRTFCRRLPVKFNRT-TTFNGLDAFEFVMEPDSFDSEVDNANSSCYCKNNR----CLKKGVGNVSPCYYN-IPLAITYPHFMHADPSLLEPFDGLQP-NVSRFTSTFVVQPQLGAPMQGTHLRLQANQVVGKVNFNRMMTPFE-NMILPLLWVDLNIDVLCLTLRLLIHGIKWGFPLLQWSAALGMLLAGVYQLCSALLLCFWPTARQFQK--------------------------------------VDQVERGTAVQVIGVGLGLATGLRKPSIHLDPEEQHHLLLGGGSFIPKMAKT----------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VDD3-1", "uniprot_id": "SNMP1_DROME", "id": "Q9VDD3-1", "name": "Sensory neuron membrane protein 1", "aln": "-------------------------------------------------------------------------MQVPRVKLLMGSGAMFVFAIIYGWVIFPKILKFMISKQVTLKP-GSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGA--KPRLQEVGPFVFDEWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTG-EEEIILPHPIMLPGGISVQREKAAMMELVSKGLSIVFPDAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKN---------------NKKLGKVVKFADEPEQDIWPDGECNTFV-GTDSTVFAPG-LKKEDGLWAFTPDLCRSLGAYYQHK-SSYHGMPSMRYTLD---LGDIRADEKLHCFCEDPEDLDTCPPKGTMNLAACVG--GPLMASMPHFYLGDPKLVADVDGLNP-NEKDHAVYIDFELMSGTPFQ-AAKRLQFNLDMEPVEGIEPMKNLP-KLILPMFWVEEGVQLN-KTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDIN------------------------------SILKDNNKVDDVASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY---------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W0X1-1", "uniprot_id": "Q9W0X1_DROME", "id": "Q9W0X1-1", "name": "Scavenger receptor class B member 1", "aln": "-------------------------------------------------------------------------MKSVQWVKILLCLILACVNVFLFVVSWGVDYRILVAREHIRFRQEMPTMDSWINSPFG-KLKNYVFNVTNAEEFRSGRDSRLKVKEIGPIVYRIVGFNDILDRNETNVRYRKHRYRVVEFLPEESVAPDVLNWTITSTNNVILG--AATKVKHTAPLAAFGFDAALMMED--IFVTDSVYYFLWEFTRPLLQT-------LSRISNIR--------PNVAVLYNALKEKEEVYTVNIGPKRGIEN-----------FFRIETLNGEVIIREQLPHTRQYDSNSCPFNVSGALDNSLFPPFVQPDTPLSIVAIESCRVLPLTYQRQ-ERYNGLDTFRYTLLQSHQKPPGCLDTSYGVKLPD---------GMFDVSQCVINDAPSAFSMPHFYGSSYNWSQHYEGYTP-NAEDHEPYILLEPVTGIPVT-EKYRFQSNIPIPDLRRFSSRLSRFSNMMIPSFWYEFEMGQLPGFVTSLMWINVNIVQHIQPYCMVLFLVLALWSVLKAIRVACGDLGYVVLFR--------------------------------------KLCGDLGTVTALETKFQATSASPDVAVK---------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :.:. * . : . : ** : : : * : : : : . . *: .* : : : * : . : ** * * . . .. * . . . : * . . ", "identical_positions": 14, "similar_positions": 35, "identity": "1.97%" }, { "cls_id": "homologset.agr.HGNC:16641", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99N14-1", "uniprot_id": "TKN4_MOUSE", "id": "Q99N14-1", "name": "Tachykinin-4", "aln": "MLPLLALLLLIGPSVCTTAGDR-EELAFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVG-----------GYQLGRIVQDLLGTRGLSIEGTCRQAASQQRARPGAVTRESLQSR-------------------EEDE-----APLTTSNV-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8CH01-1", "uniprot_id": "TKN4_RAT", "id": "Q8CH01-1", "name": "Tachykinin-4", "aln": "MLPLLALFLLIGPAVSTTTRDR-EDLTFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVEGVHPIQSAERTGYQLGRIVQDLLGTRGLSIEGSCRQETNHQSAGPGAVARESLQSQRGRSEPPNHQQHVALSLGTEEDDQSSERAPRDASQMMPRPSRP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q86UU9-1", "uniprot_id": "TKN4_HUMAN", "id": "Q86UU9-1", "name": "Tachykinin-4", "aln": "MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEG--REDEAQGSE--------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** ***:**: :*.*.: * *: ::.:***:** * *: . ***:*:***:* .:: **:******* .*** : .*.***.*.* ** *: : ", "identical_positions": 48, "similar_positions": 29, "identity": "28.07%" }, { "cls_id": "homologset.agr.HGNC:16642", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BSU2-1", "uniprot_id": "CXL16_MOUSE", "id": "Q8BSU2-1", "name": "C-X-C motif chemokine 16", "aln": "MRRGFGP---LSLAFFLFLLALLTLPGDGNQGSVAGSCSCDRTISSGTQIPQGTLDHIRKYLKAFHRCPFFIRFQLQSKSVCGGSQDQWVRELVDCFERKECGTGHGKSFHHQKHLPQASTQTPEAAEGTPSDTSTPAHS-----QSTQHSTLPSGALSLNKEHTQPWEMTTLPSGYGLEARPEAEANEKQQDDRQQEAPGAGASTPAWVPVLSLLAIVFFLTAAMAYVLCNRRATQ--QNSAGLQLWYTPVEPRP---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6AXU5-1", "uniprot_id": "CXL16_RAT", "id": "Q6AXU5-1", "name": "C-X-C motif chemokine 16", "aln": "MRRGFGP---LALTLFLFFFALLTLPGDGNQGSVAGSCYCDRTIPSGTQIPPATLNHMRKYLKTFHRCQFFIRFQLQSKSVCGGSQDQWVRELVNCFEHKQCGIGHGQSFHHQKHVPQASTRIPEATEGKPPDTSTAVQF-----QSTQQSTFPSGAPSLNKELTRHWETTILPSGYGLEARPVAEANEKQ--HKQQKEPGAGAGTQALVPVLSLLAIVFFLVAAMVCVLCNRRVTR--QSSSGLQLCYTPVEPRPQGL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H2A7-1", "uniprot_id": "CXL16_HUMAN", "id": "Q9H2A7-1", "name": "C-X-C motif chemokine 16", "aln": "MGRDLRPGSRVLLLLLLLLLVYLTQPGNGNEGSVTGSCYCGKRISSDSPPSVQFMNRLRKHLRAYHRCLYYTRFQLLSWSVCGGNKDPWVQELMSCLDLKECGHAYSGIVAHQKHLLPTSPPISQASEGASSDIHTPAQMLLSTLQSTQRPTLPVGSLSSDKELTRPNETTIHTAGHSLAAGPEAGENQKQ----PEKNAGPTARTSATVPVLCLLAIIFILTAALSYVLCKRRRGQSPQSSPDLPVHYIPVAPDSNT-", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *.: * : * ::*:::. ** **:**:***:*** *.: *.*.: . ::::**:*:::*** :: **** * *****.:* **:**:.*:: *:** .:. . ****: :*. .:*:** ..* *..: ****:.*:* *: * :** *: * * .:*:.* * * * *:** :: .*. * * * ****.****:*:*.**: ***:** : *.*..* : * ** * . ", "identical_positions": 104, "similar_positions": 78, "identity": "40.15%" }, { "cls_id": "homologset.agr.HGNC:16643", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3URD3-1", "uniprot_id": "SLMAP_MOUSE", "id": "Q3URD3-1", "name": "Sarcolemmal membrane-associated protein", "aln": "MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTSKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRK-VTHGCIVSTIKLFLPDGMEARLRS-DVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHSYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQTKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVR-LEHLQEKTLKECSSLG-IQVDDFLPKINGSTEK-EHLLSKSGGDCTFIHQFLECQKK------------------LMVQGHLT---KVVEESKLSKE----NQAKAKESDLSDTLSPSKEKSSDDTT-DAQMDEQDLNEPL-AKVSLLKDD-LQGTQSETEAKQDIQHLRKELVEAQELARTSKQKCFELQ-ALLEEERKAYRNQVEESAKQIQVLQ---VQLQKLHMDMENLQEEKDTEISSTRDKLLSAQDEILLLRQAAAEAVSERDTDFVSLQEELKKVRAELEGWRKAASEYENEIRSLQSSFQLRCQQCEDQQREEATRLQG-ELEKLKKEWDVLETECHSLKKENVLLSSELQR-------------------------QEKELHN-SQKQSFELTSDLSILQMTRKELEKQVGSLKEQHLRDAADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKDNLKLLREKGNNKPWP-WMPMLAALVAVTAMVLYVPGLARASP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P0C219-1", "uniprot_id": "SLMAP_RAT", "id": "P0C219-1", "name": "Sarcolemmal membrane-associated protein", "aln": "MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTSKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVVTHGCIVSTIKLFLPDGMEARLRSDDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELVALQEDKHSYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLSDKLKAAEGKQEEIQQKGQAEKKELQAKIDDMEEKEQELQAKIEALQADNDFTNERLTALQVVRLEPLQEKTLKECSSLGGIQVDDFLPKINGSTEKEERLLSKSGGDCTFIHQFIECQKKK-----------------LMVQGHLT---KVVEESKLSKEE---NQAKAKESDLSDTLSPSKEKSSDDTTDDAQMDEQDLNEPL-AKVSLLKDDDLQGTQAETEAKQDTQHLRKELVEAQELARASKQKCFDLQAALLEEERKAYRNQVEESAKQIQVLQV--VQLQRLHMDMENLQEEKDTEISSTRDKLLSAQDEILLLHQAAAKAVSERDTDFMSLQEELKKVRAELEGWRKAASEYEEEIRSLQSTFQLRCQQCEVQQREEATRLQGGELEKLKKEWDVLENECRSLKKENVLLSSELQR-------------------------QEKELHNNSQKQSLELTSDLSILQMTRKELENQMGSLKEQHLRDEADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKDNLKLLREKGNNKPWP-WMPMVAALVAVTAMVLYVPGLARASP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14BN4-1", "uniprot_id": "SLMAP_HUMAN", "id": "Q14BN4-1", "name": "Sarcolemmal membrane-associated protein", "aln": "MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRK-VTHGCIVSTIKLFLPDGMEARLRS-DVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVR-LEHLQEKTLKECSSLE-------------------HLLSKSGGDCTFIHQFIECQKK------------------LIVEGHLT---KAVEETKLSKE----NQTRAKESDFSDTLSPSKEKSSDDTT-DAQMDEQDLNEPL-AKVSLLKDD-LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQ-ALLEEERKAYRNQVEESTKQIQVLQ---AQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQG-ELEKLRKEWNALETECHSLKRENVLLSSELQR-------------------------QEKELHN-SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWP-WMPMLAALVAVTAIVLYVPGLARASP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B800-1", "uniprot_id": "A0ACD6B800_DANRE", "id": "A0ACD6B800-1", "name": "Sarcolemmal membrane-associated protein", "aln": "MPSALAVFSCRPNSHPFQERHVYLDEPVKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEVLSGDIIQFGVDVTENTRK-VTHGCIVSTIKLFLPDGMEARRRS-DVVPAPLPLAIDKVSANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLASTQEASESSWQALIDEDRLLSRLEVMGNQLQAYSKNQTEDGIRKELVALTEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLTEKIKLAEDKHEELTQKGLNEKKELQMRIEEMEEKEQALQARIEALQADNDFTNERLTALQVR-LEQLQEKSIKENNSLD-------------------HFLLKSGGDCTLIQQYIECQSVRQLKEAVDSSINKLSNFDEVIDAHLQNNQTTVDNSLPSPDRLKENQIDAKECDMSDTLSPSKEKSSDDTS-DGQMDEQELNEPQ-NRVSLLKEM--DRSLEAGDTEQVIPHIHRELQEAQELANTGKQKCLELQ-AMLEEERKTNRQQTEESAKQIRFLQ---TQLAKLQTDMEALREQRENTITTTREELYSAQEEILVLRHAMEAATAEREREITALQGDLSIVTAELDKWRQTAAKYEVEISNLQASFQLQS-----QHQERASQLQG-ELEKLQADCSGLQNECDSLRAEKSTLMQKLNR-------------------------LEEELDS-SRERSATLSSNLNALEKSQGDLENKLGSIQDQHQQDASKLKIQLAQAESRTRDLQKEYDDTQSLLSDLRQRYEQTEQEKRSINDELEQCKVNLKLLQDKGSNSGWMPWMPVVAAVVAVTAVVLY-PSLSKSSS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B8Z6-1", "uniprot_id": "A0A8M2B8Z6_DANRE", "id": "A0A8M2B8Z6-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEQKLKDPI-NKVSLIKDELSRSTVEASESEKVIQRLNQELQEANEQPNSSKYKCVELQ-GLLEEEKRANKQQAEESAKQMKVLQ---TQLQKLQEEMENLRDQKDSAVFSMRQETHAAQEEVQVLRRTMEKTAAEREHEVSALKGNLATLTSELEKWQQAANKYERELESVQASHLQQN-----QQRDRATKQQAGELEKVQKDCESLRRDCASLRSEREQLADKQQKEKASLQNENSSLRSEKEQLQKKQQQLEKELDS-SKKQNTSLSNTVKSLEKTQADLEKRLSVLQEEHQRDNGQLE----QSNSRIKELQKEYEEMQAELSGLRGKFENAEEEKRSVSLELQQSQERLRLMQDKDNHLSLL--QPILAVAIGLVLALLY-WCLGPLW-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q03944-1", "uniprot_id": "VPS64_YEAST", "id": "Q03944-1", "name": "Vacuolar protein sorting-associated protein 64", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVELEKRRRPPPQLQHSPYVRDQSNSQGMTKTPETSPPKRPMGRARSNSRSSGSRSNVDIDQYTIPPGLDLLPTASSPPSVHQVSQQQQLSPILANKIRSPFENQSQDQNDNSIDPTPAGQVTIPVEAVSPPA-----LDELSKFQNGSTETLFRTGSPRKKHTHIIILKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNS----GSKRDLFS---------------------------------------------------------------------------------------QQVRPDNGNFDSRVLSRNHACLSCDPTSGKIYIRDLKSSNGTFVNGVKIRQNDVELKVGDTVDLGTDIDSKFEHRKISAYVEEISVIPLMNTVSDPTNLVMKKQDHTNKNNGNSTNINGIKIDRGHHNQHIPIRSHLKENYTEAGVTSATTAQRAAFEAAMFGDINNSELDDDILGPETEVLSGIFINNSAGTSINLINMIKTLTTELSLEKQELEKLHSMQNFMQNYTINLDFINKHMIDMNEKHLLKLSTALQKTLSE-------------------------NNDALLKESEDQLKEIKQQNNKVKSACSLKEKQNHEKLQELESELRELNLQIEEERGKNLVLTQSNFNGGINNDNNAKVKQNDSREEKKDTEDTLISTEELGVVEGKRTRVSKGMLFGVVAISFGLVATAVKQLPQ-----", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q06001-1", "uniprot_id": "FAR10_YEAST", "id": "Q06001-1", "name": "Factor arrest protein 10", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTGPGPEINKEEHPSSPGKKQITYNSIPKNANLIDGS-------TNSSKRPIEKYDKRIAD-------------PTKSYFP-------------------HSISRT--PRRKYTYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLRGGKRVDSHTF--------------------------------------------------------------------------------------SQVRSDNGNFDSRVLSRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEELFVQPLLESP------IFENEDSDD------------------------------------CHTITEKEEAAAITSHIYGDSNNLELEEVILGSDTEILSGIFINNCIGTSPTLSNIIKTLAMEIPFSKCDNFKLQSMENFLINYTTHLEYTNKLLVEKNDQQLVKLQNGLRRKLSG-------------------------KYEKIIEQNRNQVKQLERDHMFFKKSFEVKKRRNNEKQKSMEREIEDLKTRLEVERYKNSQMMKKNKQK--EQELSTASKKKTTEHDTRGVPG--MNPKGTDKFSIKNTLCNHFTLLTFGTISIGIIAIVFKILSPN----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :.*:.. :. : : . : :: . : . : * .:: . : : : : : : * : : . : : :: . : :. . . : : : * * . . : . ...: : .: : :.: .. : .*: . : : :. . . : ... . * . . : ..: . ", "identical_positions": 7, "similar_positions": 83, "identity": "0.77%" }, { "cls_id": "homologset.agr.HGNC:16644", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88728-1", "uniprot_id": "IFM5_MOUSE", "id": "O88728-1", "name": "Interferon-induced transmembrane protein 5", "aln": "MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVFSTMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V7W9-1", "uniprot_id": "G3V7W9_RAT", "id": "G3V7W9-1", "name": "", "aln": "MDTSYPREDPRAPSSRKADAAAHTALSVGTPGPTPRDHMLWSVFSTLYLNLCCLGFLALVHSVKARDKKVAGDLEAAKQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSRLAKDSAAFFSTKFDEEDYN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A6NNB3-1", "uniprot_id": "IFM5_HUMAN", "id": "A6NNB3-1", "name": "Interferon-induced transmembrane protein 5", "aln": "MDTAYPREDTRAPTPSKAG--AHTALTLGAPHPPPRDHLIWSVFSTLYLNLCCLGFLALAYSIKARDQKVVGDLEAARRFGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLARLAKDSAAFFSTKFDDADYD", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:*****.***:. **. *****::*:* *.****::******:************.:*:****:*:.*:****:::*********************************::**************: **:", "identical_positions": 103, "similar_positions": 26, "identity": "76.87%" }, { "cls_id": "homologset.agr.HGNC:16645", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZXL0-1", "uniprot_id": "A0A8I5ZXL0_RAT", "id": "A0A8I5ZXL0-1", "name": "Transformer-2 protein homolog alpha", "aln": "MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSR--SHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH--GGGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRY-RRSPSP-YYSRYRSRSRSRSYSPR----RY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6PFR5-1", "uniprot_id": "TRA2A_MOUSE", "id": "Q6PFR5-1", "name": "Transformer-2 protein homolog alpha", "aln": "MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSR--SHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYR--RRSPSP-YYSRYRSRSRSRSYSPR----RY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13595-1", "uniprot_id": "TRA2A_HUMAN", "id": "Q13595-1", "name": "Transformer-2 protein homolog alpha", "aln": "MSDVEENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSNRRRHTGSRANPDPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTH---SGGGGGGGGGGGGGGGGRRRDSYYDRGYDRGYDRYEDYDYRYRRRSPSP-YYSRYRSRSRSRSYSPR----RY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P19018-1", "uniprot_id": "TRA2_DROME", "id": "P19018-1", "name": "Transformer-2 sex-determining protein", "aln": "---------MDREPLSSGR--LHCSARYKHKR---SASSSSAGTTSSGHKDRRSDYDYCGSRRHQRSSSRRR-----SRSRSSSESPPPEPRHRSGRSSR---DRERMHKSREHPQASRCIGVFGLNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYFEKLSDARAAKDSCSGIEVDGRRIRVDFSITQRAHTPTPGVYLGRQPR---GKAPRSFSPRRGRRVYHDRSASPYDNYRDR-YDYRNDRYDRNLRRSPSRNRYTRNRSYSRSRSPQLRRTSSRY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .**. *..: .** * : * *.* ... *..*. **. . *: :* :* * * ** *.* .** *:* .** :*.* ** :*:.. *:*****. *:::.:**:*.:***:. :::* * :* *****.*:***::.*:: * : ..*:*:********:***:********:*:** .: . . . . * * * **. ** ** :* * ***** *:* ** ***** . * **", "identical_positions": 112, "similar_positions": 71, "identity": "38.62%" }, { "cls_id": "homologset.agr.HGNC:16646", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35679-1", "uniprot_id": "ISK4_MOUSE", "id": "O35679-1", "name": "Serine protease inhibitor Kazal-type 4", "aln": "MAMHLWLVTLTLVPLLGMDRELMVSAGSLVFPRMPFCEHMAELPNCPQTPNLICGTDGLTYENECHLCLTRMKTMKDIQIMKDGQC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "E9PU35-1", "uniprot_id": "E9PU35_RAT", "id": "E9PU35-1", "name": "", "aln": "MAMHLWLVTLTLVPLLAMDRELPVSAARLVFSRMPICEHMAEFPNCPRSPNLICGTDGLTYENECHLCVTRMKTKKDIQIMKDGKC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O60575-1", "uniprot_id": "ISK4_HUMAN", "id": "O60575-1", "name": "Serine protease inhibitor Kazal-type 4", "aln": "MAVRQWVIALALAALLVVDREVPVAAGKLPFSRMPICEHMVESPTCSQMSNLVCGTDGLTYTNECQLCLARIKTKQDIQIMKDGKC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FCI0-1", "uniprot_id": "E7FCI0_DANRE", "id": "E7FCI0-1", "name": "", "aln": "MSMGLLVFGLFLL----------LSSGASGSSRKPTCAGMPEILACPMNLAPVCGSDGNTYSNECLLCVERLKTKSDILIAKDGDC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:: :. * * :::. .* * * * * *. :**:** ** *** **: *:** .** * ***.*", "identical_positions": 30, "similar_positions": 16, "identity": "34.88%" }, { "cls_id": "homologset.agr.HGNC:16647", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LGZ2-1", "uniprot_id": "A0ABK0LGZ2_RAT", "id": "A0ABK0LGZ2-1", "name": "C-X-C chemokine receptor type 6", "aln": "MFAMDDGHQEKDLDDDVYGGDPWLFNNSSGNSQEHKRFLKFKEVFLPCMYLVVFVLGLLGNSLVLIIYIFYQRLRSLTDVFLLNLPLADLVFVCTLPFWAYAGTYEWVFGTAMCKTLRSMYAMNFYVSMLTLTCITVDRFVVVVQATKAFNRQAKWKIWGQVTCLLIWVVSLLVSLPQIIYSRVGHIDRLICQFHNEAISTVVLVLQMTLGFFLPLLTMILCYSGIIKTLLHARNFQKHKSLKIIFLVVATFLLTQTPFNIAMLIQWISWEYSTITSFQYVVLVTEAIAYLRACLNPVLYAFVGLKFRKNLWKLMKDISCLSRLGVSSQWKSSEDNSKTCSASHNAETTSMFQL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EQ16-1", "uniprot_id": "CXCR6_MOUSE", "id": "Q9EQ16-1", "name": "C-X-C chemokine receptor type 6", "aln": "---MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEVFLPCVYLVVFVFGLLGNSLVLIIYIFYQKLRTLTDVFLLNLPLADLVFVCTLPFWAYAGTYEWVFGTVMCKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVICLLIWVVSLLVSLPQIIYGHVQDIDKLICQYHSEEISTMVLVIQMTLGFFLPLLTMILCYSGIIKTLLHARNFQKHKSLKIIFLVVAVFLLTQTPFNLAMLIQSTSWEYYTITSFKYAIVVTEAIAYFRACLNPVLYAFVGLKFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSSKTCSASHNVETTSMFQL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O00574-1", "uniprot_id": "CXCR6_HUMAN", "id": "O00574-1", "name": "C-X-C chemokine receptor type 6", "aln": "-MAEHDYHEDYGFSS---------FNDSS--QEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKSSEDNSKTFSASHNVEATSMFQL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .* *:: : . **:** .:*:: **:*.:*****:****** **:******:* ***::*::******:******************** :***** .***:* .:*::***.*** *********:***:****:*:*** **:* .*****:***********..* .:*:*** :*.* ***:**. **************:*** ******** .****:********:*.***** ***: :*: *** ::***:*.::*******:************.******.***:***.**. **** *******.*** *****.*:******", "identical_positions": 240, "similar_positions": 68, "identity": "67.8%" }, { "cls_id": "homologset.agr.HGNC:16648", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AEG5-1", "uniprot_id": "A0A8I6AEG5_RAT", "id": "A0A8I6AEG5-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MGQGSSKPVRPPPAGGYQSGPGRSYGRRHAYVSFRPSMSQQERIASQRRTTSEVPMHRSTANQS-KRSRSPFASTRRRWEDNEGSGASLAVENEDYSRYPPREYRASGSRRGMAYGHIDTLVARDSEEEGAGPVDRLPVRGKTGKFKDD----PEKGARSSR-----FSSVNHDVKEERGKVESPPAARCSARRAELSKQNGSLASQISSAEGRAAVKGNHS-LERERQNLPARPSRAPVSICG---------GGENTPKSAEEPVVRPKVRNVAAPNCMKPKVFFDTDDDDDVPHSTSRWRDAADAEEAHADGLARR-GRGEAAGGSSEPRYAEDQ-DARNEQAKPEKVSRRRRTMADPDFWAYSDDYYRYYEEDSDSDKEWMAALRRKYRSRDQPQSSSGESWEPLPGKEDQEPQQARGNVNT-----------AGAGSLAGAGSNGSGYPEEVQEPSLQEEEQASLEEGEIPWLRYNENE-SSSEGDNESTHELMQPGMFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL-------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O55176-3", "uniprot_id": "PJA1_MOUSE", "id": "O55176-3", "name": "E3 ubiquitin-protein ligase Praja-1", "aln": "-------------------------------------MSHQERIASQRRTTAEVPMHRSTANQS-KRSRSPFASTRRRWDDSESSGASLAVESEDYSRYPPREYRASGSRRGLAYGHIDTVVARDSEEEGAGPVDRLPVRGKAGKFKDD----PEKGARSSR-----FTSVNHDAKEECGKVESPPAARCSARRAELSKQNGSSASQISSAEGRAAAKGNNS-LERERQNLPARPSRAPVSICG---------GGENTPKSAEEPVVRPKVRNVATPNCMKPKVFFDTDDDDDVPHSTSRWRDAADAEEAHAEGLARR-GRGEAAS-SSEPRYAEDQ-DARSEQAKADKVPRRRRTMADPDFWAYTDDYYRYYEEDSDSDKEWMAALRRKYRSREQPQSSSGESWELLPGKEELERQQ------------------AGAGSLASAGSNGSGYPEEVQDPSLQEEEQASLEEGEIPWLRYNENE-SSSEGDNESTHELIQPGMFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL-------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NG27-1", "uniprot_id": "PJA1_HUMAN", "id": "Q8NG27-1", "name": "E3 ubiquitin-protein ligase Praja-1", "aln": "MGQESSKPVWPNPTGGYQSNTGRRYGRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQS-SVASQ-SSSEGKLATKGDSSERERREQNLPARPSRAPVSICG---------GGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARR-GRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEE-QASLEEGEIPWLQYHEND-SSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL-------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AZZ7-1", "uniprot_id": "A0A8M3AZZ7_DANRE", "id": "A0A8M3AZZ7-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MGQEAGKSAWPKPAGGYQTISGRRYGRRHAYISFKPFTDKQRATSTVDCQNMQRTSDQKSQAMESKGNISSVLQTILPISCTN----SVRPEINAAAHHPEGHNRRHSSLRRVPKAPLNHFKRPKNDQVVPYDRKHCSGREKSKVWPIDENHKTNSKALSYINIDAYEPDSSGAEEEDLSSDPSHAACRRLDGICELGGNVDSLDDSRSSLFRKNRMKQMASSKDSTDLFDDTPDCQRTVKTNGKPSFFLEDGAPKCYGDTASAVSHKNKEQNNPGETFESEMVVRPKIRKQTSETHLERRKRSEKEETGHLSGSAIRNKCGSAPPGFLAQTCPENEFLFNFPAMALSDLNSEDRKSEDE--YAKVEDEDDIWEDLENFGEKCEPSMKADESSSEFSEGEWSASWTSDSGLDKERCTSEES--------------WETLPGIDEPPASRSSSLEEVPSLNLALEEQTPLEEGEIPWLMYNEDSGSSSDEDPDGVSQFVHPGLFILDGNNNLEDDSSMSEDLDTEWRFLDEFGDGFGMAQAISYVDHSQLLTYMALEERLAQAMEAALAHLESLAIDVEQAHPPATEQIIDCLPQITMHAEN--IEQEQCCAICCCEYVKDEIATLLPCRHMFHKLCVTLWLRKSGTCPVCRHVLTPAVTTDPASLSSEQETSPSTHSASGGAC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .::. :: . : . .:.: * . *.. * . .: .: : : :::* . * .* * :. . :: ..:: . .: . * *: : * .:. * * .. . .*: .. . .*.* .:: : * .. ** : * * : : .: .*. * . : .:*. : * :* . . . :. . .: .* : : . : .* .* * * *.:. .*:: . ..: . *. * :: :* :: .: .:: .::: . * : . .. . ** .* :. . . . . :. *. *** . .* * *:.********* *:*:. ***: * :. ::::**:*:************:****:.:* ::* *.**:*:*:****** *:***************:*********:*** *:***::: **.**:* : :: : ** **.***.****.*:** ***:* *** **::**:********* ::.*.: ", "identical_positions": 165, "similar_positions": 185, "identity": "24.16%" }, { "cls_id": "homologset.agr.HGNC:1665", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P27615-1", "uniprot_id": "SCRB2_RAT", "id": "P27615-1", "name": "Lysosome membrane protein 2", "aln": "---MARCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEILQGEIPL-LEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPLLTVVEMAQQP-----------------------FLREIIEAMLKAYQ------------------------------QTLFVTHTVHELLWG-----------YKDEVLSLVH-------IFRPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFTKIVEWNGKTSLDWWT-------TDTCNMINGTDGDSFHPLISKDETLYIFPSDFCRSVYITFSSFENVEGLPAFRYKVPAEILAN---SSENAGFCIP--------EGNCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQINTYVKKLDDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFGLIFTWLACRGQGSTDEGT------------------------------ADER---------APLIRT------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35114-1", "uniprot_id": "SCRB2_MOUSE", "id": "O35114-1", "name": "Lysosome membrane protein 2", "aln": "---MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEIPL-LEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQLT-----------------------LLRELIEAMLKAYQ------------------------------QKLFVIHTVHELLWG-----------YKDEILSLVH-------IFKPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWT-------TDTCNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILAN---TSENAGFCIP--------EGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGLVFTWLACRGQGSMDEGT------------------------------ADER---------APLIRT------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14108-1", "uniprot_id": "SCRB2_HUMAN", "id": "Q14108-1", "name": "Lysosome membrane protein 2", "aln": "---MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPR-VEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLTVIEWSQVH-----------------------FLREIIEAMLKAYQ------------------------------QKLFVTHTVDELLWG-----------YKDEILSLIH-------VFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWI-------TDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILAN---TSDNAGFCIP--------EGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMALGVFFGLVFTWLACKGQGSMDEGT------------------------------ADER---------APLIRT------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A953-1", "uniprot_id": "A0AB13A953_DANRE", "id": "A0AB13A953-1", "name": "", "aln": "-MRLRLCCVSTAGALCVLLLICGIALELTRVLQKLVNNTVKQQIVLENGTEAFSVWQNPPPPVYMQFYFFNLTNPAEVMSGDKPS-VVQIGPYTYREYRPMEEVKFMDNGTRVAAINPKTYVFEPNMSRGS-QDDLVRTVNIPAVTVMEKYKDS-----------------------ILARLISDLMKAKG------------------------------VGVFETFRVGDLLWG-----------YEDPLLKELH-------MLVPDD--HFGLFYKKNGTEYDSYVLLTGKPDYQDFASIDEWNGQRSLNWWS-------SEECNMINGTDGASFHPIITKADRLYIFSSDLCRSLYVQYECDVSVQGVPGFRFVPPADVFSSPDINPDNAGFCVP--------PGHCLGSGLLNASVCKQGAPIIMSSPHFYQADQKFVDDIWGMKPIKEEHQTFADINPLTGIVLQGAKRVQVNVYLQQHSSFSQTGKIQTLVFPVMYINESAFIDEESAKKLHAVVLNANVVINIPFIVISVGILLGIIFIVLMCRQQ--MPPST------------------------------LAER---------EPLLSS------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A2R8Q7M1-1", "uniprot_id": "A0A2R8Q7M1_DANRE", "id": "A0A2R8Q7M1-1", "name": "", "aln": "-MRKSSCCMYSCGAAGALLLLAGIALFASGLFQTLIHNKLKKEITLTEGSKVFATWKNPPPPVYMEFFFFNVTNPEAFLKGEAKARLSEMGPYTYREYRPKHNVSFVDNGTKVAAYTPKVFVFVPEKSVGDPSVDMVTTVNIPAVAVMNRIKGAG---------------------FLVSSAMSLYMKSIG------------------------------AEMFMTHTVDELLWG-----------FKDPLLTKLR-------SIKPETDEFFGLMLHKNGSDDGEFVYHTGEHNYLDYGRIFTWKGEKLMSFWK-------TNQSNMINGTDGSAFHPFLTKEERLDVFTADLCRSIHMRFEKEVEVKGIPAYRFTPPRAVLASGTNNPENEGFCLT--------PKKCLDDGVLDVSVCRQGAPVVVSFPHFHLGDEKYVQAVEGLSPVHEQHQTFLDLNPTMGVPVRAMKRAQINIHLERVTGFPMTRNLESTIFPIIFLNESVVIDNASAERIQKLLLVVTLVSHFPLILVALGVILLIVAVILAVRYYQNKTEVKRFDFAEAFHCTAPSAKKDTSYAPVSAKVDDQDEKNGTYIGM--TPVDKS------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E1JI63-1", "uniprot_id": "SNMP2_DROME", "id": "E1JI63-1", "name": "Sensory neuron membrane protein 2", "aln": "--MIHWSLIVSALGVCVAVLGG---YCGWILFPNMVHKKVEQSVVIQDGSEQFKRFVNLPQPLNFKVYIFNVTNSDRIQQGAIPI-VEEIGPYVYKQFRQKKVKHFSRDGSKISYVQNVHFDFDAVASAPYTQDDRIVALNMHMNAFLQVFEREITDIFQGFANRLNSRLNQTPGVRVLKRLMERIRGKRKSVLQISENDPGLALLLVHLNANLKAVFNDPRSMFVSTSVREYLFDGV-RFCINPQGIAKAICNQIKESGSKTIREKSDGSLAFSFFGHKNGSGHEVYEVHTGKGDPMRVLEIQKLDDSHNLQVWLNASSEGETSVCNQINGTDASAYPPFRQRGDSMYIFSADICRSVQLFYQTDIQYQGIPGYRYSIGENFINDIGPEHDNECFCVDKLANVIKRKNGCLYAGALDLTTCLD-APVILTLPHMLGASNEYRKMIRGLKPDAKKHQTFVDVQSLTGTPLQGGKRVQFNMFLKSINRIGITENLPTVLMPAIWVEEGIQLNGEMVAFFKKKLINTLKTLNIVHWATLCGGIGVAVACLIYYIYQRGRVVEP--------------------------------------------PVK--------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VDD3-1", "uniprot_id": "SNMP1_DROME", "id": "Q9VDD3-1", "name": "Sensory neuron membrane protein 1", "aln": "MQVPRVKLLMGSGAMFVFAIIYG-----WVIFPKILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPR-LQEVGPFVFDEWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQRE------------------------KAAMMELVSKGLSIVFP-------------------------DAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHFLFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWP-------DGECNTFVGTDSTVFAPGLKKEDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDLGDIRA---DEKLHCFCEDP-----EDLDTCPPKGTMNLAACVG-GPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLDMEPVEGIEPMKNLPKLILPMFWVEEGVQLNKTYTNLVKYTLFLGLKINSVLRWSLITFSLVGLMFSAYLFYHKSDSLDINSILKDNNKVDDVASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : :: . :. :.:.:.: *:. : : * *: .:.**:**. . * : ::**:.: : : :: : * * : : : . : :. * . : :: . : . . : *.:: . * : : * . : .. . * .* : ***. : * : : : *..*:***: :. . .*:*. *: : . ** * * :: : * .*:: : **: .. . : *: * :.* : *.: * .:. ** *.* :. : .: . ::* ::::*. :: . .: : . : : * ", "identical_positions": 50, "similar_positions": 128, "identity": "8.04%" }, { "cls_id": "homologset.agr.HGNC:16650", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CY73-1", "uniprot_id": "RM44_MOUSE", "id": "Q9CY73-1", "name": "Large ribosomal subunit protein mL44", "aln": "MASAVFRLLQQGPR----------RLLAPAVP-TLAPPVRGVKKGFRA-AFRFQKELERWRLLRCPPPPVRRSEKPNWDYHAEVQAFGS----------------RLQETFSLDLLKTAFINSCYIKSEEAK--RQSLGIEKEAALLNLKDNQELFEQGLSFSHRCLTQFLEDEFPDLPAEGTESLVSFLTGEAVVCHVARNLAVEQLTLSAEFP--------------------------------------VPLPVLRQTFFAVIGALLQSSGPERAALFIRDFLITQMTGKELFEMWTVVNPMGLLVEELKKRNISAPESRLTRQSGSTTALPLYFVGLYCDRKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWDYSKPKESPKRAEQTSVAS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H9J2-1", "uniprot_id": "RM44_HUMAN", "id": "Q9H9J2-1", "name": "Large ribosomal subunit protein mL44", "aln": "MASGLVRLLQQGHR----------CLLAPVAP-KLVPPVRGVKKGFRA-AFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGH----------------RLQENFSLDLLKTAFVNSCYIKSEEAK--RQQLGIEKEAVLLNLKSNQELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFP--------------------------------------VPPAVLQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPKET-LRAEKSITAS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1RB48-1", "uniprot_id": "F1RB48_DANRE", "id": "F1RB48-1", "name": "Large ribosomal subunit protein mL44", "aln": "MAACRALVSRAVLP----------LHYHHVCRGVMLTQIREKKRWMKAYMFVMRKKLK----LEGPPAPKPRSEQPNFDYHAEVEAFGV----------------RLQESFSVDLLKTAFVNSCYLRSEVER--RKALGLDSESAILNLKDNTELRDHGQHFTTGFLSDWCKNSFPNLPDEGVAAIAGHLTGSEVICHVARNLAVEELTMSAEFP--------------------------------------VPDHILQGTFFAVIGALEQSSGPVRAGLFIRDFLVTQLIGKDLFDMWKVVDPMGLLVEELTRKGVALPEPRLIRSAGASTVLPLYFVGLYSDRKLLAQGPGETVLIAEEEAARVALRKLYGFTENRRPFDFTAPRDQLQKPSTQALTSG", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VNC1-1", "uniprot_id": "Q9VNC1_DROME", "id": "Q9VNC1-1", "name": "Large ribosomal subunit protein mL44", "aln": "-MSFLRSAVGLLAR----------VKLLEGSP--TVQTRRHIKRWVSP----TLRELAHRQKKLGPQKPERRSGFVEWNQRSELFAFGK----------------RLGESFELSELQRAFTEKSFAEREEDR--RRQLGIEE--SDLQMPHNSDLVEKGQQIARAYVEAFLQHQLPKVPNEGLQAIASYLLSTETLAHVSTHLGTKDLIQSTEYP--------------------------------------PSAESQAKSLHAVIGALASSSGIERAFIFVRDFICTQLNQKDLLEVWTPQEPIQLLEKICQERKLGEAEPRLLGDCGKNTVLAAYQVGIYANRQLLGKGFGEDVKTATETAALDALQSIFDTRDNRRPFDFAIQLEPKTVRLG------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36516-1", "uniprot_id": "RM03_YEAST", "id": "P36516-1", "name": "Large ribosomal subunit protein mL44", "aln": "MGIVLKRAIAAGMKPFPNSTWHWSRTIRPFSQHLSSTCFLQQSSRFTSKRYLHLSTLTQQEKRFLPESELAKYKEYYQGLKSTVNEIPESVASKSPSLRTLHKRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDNHGLNIMGKNLLSYHVTKSIIQKYPRLPTVVLNAAVNAYISEAVLAHIAKYWGIEVETTSVLSRYLKMEPFEFTLGRLKFFNNSLNSKDGIELITGKNFSETSALAMSVRSIIAAIWAVTEQKDSQAVYRFIDDHIMSRK--LDITKMFQFEQPTRELAMLCRREGLEKPVSKLVAESGRLSKSPVFIVHVFSGEETLGEGYGSSLKEAKARAATDALMKWYCYEPLAQQEPVIDPGTVVV----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . * * : . :: : : :* : : . *. .: . : . : .: . : * * * : : .. * :* .. . .:.*:: . : * . :: *.* *: .... . *: *.: :: :: .:: :* * .. : . .:* ..* : . : * ::...: :.:* *. : * ** ** . : : ", "identical_positions": 28, "similar_positions": 85, "identity": "6.97%" }, { "cls_id": "homologset.agr.HGNC:16651", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A104-1", "uniprot_id": "D4A104_RAT", "id": "D4A104-1", "name": "Large ribosomal subunit protein mL45", "aln": "--MAAPIPRGLSSLSRTLGWWSRQ-----PILVTRS-----TAVVPVKSKSR-FRPPTRE------------------PNYKTEKEFLEYARKAGLVIPQERLERPIHLACTAGIFDPYVPPEGDARMSSLSKEGLTQRTERLRKNVASQLAIRKIKEFDANFKTKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMVWELKYKTVRWSFVESLEPAQVVHVRSSGLVNQSNMYGQVTVRLHTRQTLAIYDRFGRLMYGQEDVPKDVLEYVVFERHLMNPYGSWRMHAKIVPPWAPPKQP------ILKTLMIPGPQLKPWE---EYEETQGEAHKPQLT---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D0Q7-1", "uniprot_id": "RM45_MOUSE", "id": "Q9D0Q7-1", "name": "Large ribosomal subunit protein mL45", "aln": "--MAAPVPRGLSSLYRTLGWWSRQ-----PILVTQS-----TTVVQVKTKSR-FRPPTPE------------------PKYKTEKEFLEYARKAGLVIPQERLERPIHLACTAGIFDPYVPPEGDARMSSLSKEGLTQRTERLRKNAASQLAIRKIREFDANFKTKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMVWDLKYKTVRWGFVESLEPAQVVHVRCSGLVNQSNMYGQVTVRLHTRQTLAIYDRFGRLMYGQEDVPKDVLEYVVFERHLMNPYGSWRMHAKIVPAWAPPKQP------ILKTLMIPGPQLKPWE---EYEETQGEAQKPQLA---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BRJ2-1", "uniprot_id": "RM45_HUMAN", "id": "Q9BRJ2-1", "name": "Large ribosomal subunit protein mL45", "aln": "--MAAPIPQGFSCLSRFLGWWFRQ-----PVLVTQS-----AAIVPVRTKKR-FTPPIYQ------------------PKFKTEKEFMQHARKAGLVIPPEKSDRSIHLACTAGIFDAYVPPEGDARISSLSKEGLIERTERMKKTMASQVSIRRIKDYDANFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMTWDIKYKTVRWSFVESLEPSHVVQVRCSSMMNQGNVYGQITVRMHTRQTLAIYDRFGRLMYGQEDVPKDVLEYVVFEKQLTNPYGSWRMHTKIVPPWAPPKQP------ILKTVMIPGPQLKPEE---EYEEAQGEAQKPQLA---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QEK4-1", "uniprot_id": "E9QEK4_DANRE", "id": "E9QEK4-1", "name": "Large ribosomal subunit protein mL45", "aln": "--MAASICRTLKCLQPTSCQNIKYGSSLLDVRLWQA-----VLRVPVRTKRRLFIPPSAN------------------IKSKTQDEQEKKARAAGVVVRQEYMERPINISCTAGIYDPYVPPEGDARLSTLTKEGLKQRTEQLRQTAASQLAIRKIKDYDSTFTSKEFPGIGQQIFIDAHAALTEFNKEKLHSLVTERCYPEMVRGNRYKTLRWRFIESLEPPRLVQARCPDMISKGNLYGQVTVRMHSRQTLAIYDRFGRLMLGDEEEPRDVLEYLVMERHLVNPYGRWRLHGKIVPAWAPPKDP------IIKTVMIPGPKLKSGE---QFEDLNYQIPKPNAVQWHK-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VCX3-1", "uniprot_id": "RM45_DROME", "id": "Q9VCX3-1", "name": "Large ribosomal subunit protein mL45", "aln": "MEKLASAKTCLKLLQVMPGVQQAALLPGGGLGVLASPLQNLIQMQQVRHRQTKHWKPEFKRLRKLKFVKMDLPNLREKQEDITKEEMRSRMKERGVLPPRPWMERPFHISCTGGIFEAYVPPEGDGKKSIISTSGAKQKLEFLEKKSKSLMAVRKIRSYDENFSSDDFGAEAQDIYIQAHTHMAAKDKYKIREFVSERCYPEMMHNVKDKTIRWKFLQSLEPPRVVHARVTEVITKENQFAQVTVRFHSQQMLAIYDRFGRLMHGSEIITKDVLEYVVFEKHISNEYGKWRLHDKIIPDWLPAKQPAPITYRLIEDAEEPPKELSAGDAEVKQVDSVGEQSKEQLPLATPVESHTKPSLAI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. :. * : : : *: : . * : : *:.* . : *:: :*.::::**.**::.*******.: * ::..* :: * :.:. * :::*:*:.:* .*. .:* .::*:*:** : :: ::: :*:*:*:*:* : **:** *::****.::*:.* . ::.: * :.*:***:*::* *********** *.* .:*****:*:*::: * ** **:* **:* * *.*:* ::: * :*.. : : : : * : ", "identical_positions": 91, "similar_positions": 109, "identity": "25.21%" }, { "cls_id": "homologset.agr.HGNC:16652", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7EW23-1", "uniprot_id": "F7EW23_RAT", "id": "F7EW23-1", "name": "Large ribosomal subunit protein uL29m", "aln": "MAATS----LVGICRRASAFLKAACSLVNPKT----PAHSGCRPPLSLLHKNTPHATSFLQCKFLHTTLSRKGLEEFFDDPKNWGEEKVKSGASWTCQQLRNKSNEDLHKLWYVLLKERNMLLTLEQEAKRQR--LPMPSPERLEKVVDSMDALDKVVQER----EDALRLLQTGQEK-------PRPGAWRQDIFGRIVWHKFKQWPIPWYLNKRYNRRRFFAMPYVDSFIRLRIEKHARTEARKRSLQKKKEK----------ILQAKFPHLSQDRKSKLGTEPRALCLLGKSSTTELNPKPQIE--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K2Y7-1", "uniprot_id": "RM47_MOUSE", "id": "Q8K2Y7-1", "name": "Large ribosomal subunit protein uL29m", "aln": "MAATS----LVGICRRASAFLKAACSLVNPKD----AAHSGCRSSLSLLHKNTPHVTSFLQCKLLHTTLSRKGLEEFFDDPKNWGEEKVKSGASWTCQQLRNKSNEDLHKLWYVLLKERNMLLTLEQEAKRQR--LPMPSPERLEKVVDSMDNVDKVVQER----EDALRLLQTGQEK-------PRPGAWRRDIFGRIVWHKFKQWPIPWYLNKRYNRRRFFAMPYVDRFIRLRIEKHARIEARKRSLQKKKEK----------ILHAKFPHLSQERKS--------------SSV------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HD33-1", "uniprot_id": "RM47_HUMAN", "id": "Q9HD33-1", "name": "Large ribosomal subunit protein uL29m", "aln": "MAAAG----LALLCRRVSSALKSSRSLITPQV----PACTGF--FLSLLPKSTPNVTSFHQYRLLHTTLSRKGLEEFFDDPKNWGQEKVKSGAAWTCQQLRNKSNEDLHKLWYVLLKERNMLLTLEQEAKRQR--LPMPSPERLDKVVDSMDALDKVVQER----EDALRLLQTGQER-------ARPGAWRRDIFGRIIWHKFKQWVIPWHLNKRYNRKRFFALPYVDHFLRLEREKRARIKARKENLERKKAK----------ILLKKFPHLAEAQKS--------------SLV------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F6A5-1", "uniprot_id": "E7F6A5_DANRE", "id": "E7F6A5-1", "name": "Large ribosomal subunit protein uL29m", "aln": "MAAAVTSRLTAAVCRQFQRFVTVS-AHAKPQ-----FATSTFQPCHQRQVADSWWFRSSLNSRSLHTTCVRKGLDEFFDLPENWGEETVKSGAPWTAKQLRVKSNEDLHKLWYVLLKEKHMLLTVEQEAKRQC--VQMPSPERIKKVERSMIRLDTVVRER----EDALRLLQTGQEK-------ARPGEWRRNVFGQNFWYRYREYPIPWYLNSRYKRKKFYEPAHVFPYTRLRIEKYLKSKVRKERREKRNQK----------RLAAMFQKKTALA-------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P36517-1", "uniprot_id": "RM04_YEAST", "id": "P36517-1", "name": "Large ribosomal subunit protein uL29m", "aln": "MWKRSFHSQGGPLRARTKFTKPKPKQPVLPKDKIRPPTQLTHHSNNLRITEPIPPTTSNLRCPDDHPLWQFFSNKKFIRSADDLPPSSHIR--PWSIPELRHKSFNDLHSLWYNCLREQNVLARENHLLKNIVGSTHDEFSELSNSIRTTMWQIRHVLNERELAYSASREFLQDESERKKFLDTLANDYFLNKDIPDDEVASMLTRFQLAIFGISETIQDNTVDINFIDGIKFLANLKLQRFKDSNDLISEISQEPITDVGESFILFTSDFEPHAVQEACVAIKDLRKSPDNKVPKLDELPTVRKYLKQLIHASSVEQATA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : : . . *: : * . *. . .:*: ..: .. .*: :** ** :***.*** *:*:::* :: *. .* ..: :* : *:.** . : .:** .*: .. .::: . . .: :. . .. : . .: * * : : : .. . : : * : ", "identical_positions": 31, "similar_positions": 71, "identity": "9.66%" }, { "cls_id": "homologset.agr.HGNC:16653", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LPD6-1", "uniprot_id": "A0ABK0LPD6_RAT", "id": "A0ABK0LPD6-1", "name": "Large ribosomal subunit protein mL48", "aln": "EHQLEFPQRIPEVSARGHDGAGGAAAAASAQRPLPDRCSSNPLTKRAERKGQPRSPLGPCRAEQRGEAEGRVTPPTGSRRRRLPAESPSTQPGPRPRRDAGRCRRQPAVRSGFASLAPFLPSERGAETELSGLLPCRGERGRSGFDWRLEKTGGGGTEFRVLGLWTNTVSKQGFSLQRFRILGENPIYSAGGIVR-TSRHYKTKPTHGIGRYRHLVKVLEPKKKKAKVELRAINVGTDYEYGVLNIHLTAYDMTLAESYARYVHRLCNQLSIKVEESYAMPTKTMEVMRLPDQGNKMVLDSVLTTHERVVQISGLSATFAEIFLEILQINLPEGVRLSVREHTEEDFKGRFKARPELEELLAKLN-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8JZS9-1", "uniprot_id": "RM48_MOUSE", "id": "Q8JZS9-1", "name": "Large ribosomal subunit protein mL48", "aln": "---------------------------------------------------------------------------------------------------------------------------------MSGTLG------------------------KVLGVWTNTVSKQGFSLLRFRSLGENPIFSAGGILW-TSRHYKTKPTHGIGRYRHLVKVQEPKKKKAKVELRAINVGTDYEYGVLNIHLTAYDMSLAESYAQYVHRLCNRLSIKVEESYAMPTKTMEVMRLPDQGNKMVLDSVLTTHERVVQISGLSATFAEIFLEVLQSNLPEGVRLSVREHTEEDFKGRFKARPELEELLAKLN-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96GC5-1", "uniprot_id": "RM48_HUMAN", "id": "Q96GC5-1", "name": "Large ribosomal subunit protein mL48", "aln": "---------------------------------------------------------------------------------------------------------------------------------MSGTLE------------------------KVLCLRNNTIFKQAFSLLRFRTSGEKPIYSVGGILLSISRPYKTKPTHGIGKYKHLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPEGVRLSVKEHTEEDFKGRFKARPELEELLAKLK-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VQ35-1", "uniprot_id": "Q9VQ35_DROME", "id": "Q9VQ35-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRRILPSVRLALQVPKATTTA------------VRSTSGSVYEPDYLESLKPKFP---------------QYESLNVQIKGYDYPQLESYQRFLHGLAEYLDLDVSDCYALPPQKTTVQRLRPNSTVIESEYKLTTYERNLQLNNVDAPVYPQFLRLAQAALPEGVSLQVQEYTDDCEERRYVPDKELLDLKDELERMGGPTTTRKK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: :. *: :. :. .:.* * . :: :** :* **:::..** . *** :::* *.: *.:.*.:.**:*.:. * :* :.. : : ***:** :*:..:.*.. **.: * ***** *.*:*:*:: : *: . ** :* :*: ", "identical_positions": 46, "similar_positions": 67, "identity": "12.23%" }, { "cls_id": "homologset.agr.HGNC:16654", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VDT9-1", "uniprot_id": "RM50_MOUSE", "id": "Q8VDT9-1", "name": "Large ribosomal subunit protein mL50", "aln": "---MAALIVSRLARRGWLWKLPLATRREFWSRSRKEKEPVVAETVEEVKKEPVLVCPPLR-SRAYTPPSDLQSRLESHIKEVLGSSLPNNWQDISLDDGHMKFRLLAGLADGLGHAVPNSRLHQMCRVRDVLDFYNVPVQDKSKFDELVASNLPPNLKISWSY-------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N5N7-1", "uniprot_id": "RM50_HUMAN", "id": "Q8N5N7-1", "name": "Large ribosomal subunit protein mL50", "aln": "---MAARSVSGITRRVFMWTVSGTPCREFWSRFRKEKEPVVVETVEE-KKEPILVCPPLR-SRAYTPPEDLQSRLESYVKEVFGSSLPSNWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY-------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0LUL5-1", "uniprot_id": "A0ABK0LUL5_RAT", "id": "A0ABK0LUL5-1", "name": "Large ribosomal subunit protein mL50", "aln": "YLRHESLNAGTSENNEYTLRFESSPQVLTLTSLRKEKELVVAETVEEVKKAPALVCPPLR-SRAYTPPSDLQSRLESHIKEVLGSSLPNNWQDISLDDGHVKFRLLANLADDLGHAVPNSRLHQMCRVRDVLDFYNVPVQDRSKFDELIASNLPPNLKISWNY-------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9V3E3-1", "uniprot_id": "Q9V3E3_DROME", "id": "Q9V3E3-1", "name": "Large ribosomal subunit protein mL50", "aln": "--------MAAILRK--TLILAGSLHRSFASAAKAAKAKPVKTSTISAVGESIAAKGFLRPHKPYSPPADAAERIR-----TVAASLQ--LKSDQLGNLSEKFEFLNACFQELQHGVPNSQVHELRTVSDVIAFYQTAVDTTVPFDALKRIELPENLHIQYEYVRFHPETDTKFDGKTAFPKSSTLVTGLKYRGKYEGHEAKRSWP", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. . : : : * * :. . . . ** :.*:** * .*:. ...:** :. .* : **.:* : * * ****::*:: * **: **:..:: ** * :** **:* :.* ", "identical_positions": 36, "similar_positions": 43, "identity": "17.48%" }, { "cls_id": "homologset.agr.HGNC:16655", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D0Y8-1", "uniprot_id": "RM52_MOUSE", "id": "Q9D0Y8-1", "name": "Large ribosomal subunit protein mL52", "aln": "--MAALGTWLSS-----VRRLHCSVVARAGGQWRLQQGLAANPSGYGPLTELPDWSFADGRPAPPMKGQLRRKAQREKLARRVVLLTQEMDAGIQAWKLRQ-QKLQEE-RKKEHDLKPKGTLLRSPLPNQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LDF4-1", "uniprot_id": "A0ABK0LDF4_RAT", "id": "A0ABK0LDF4-1", "name": "Large ribosomal subunit protein mL52", "aln": "--MAALGTWLSS-----VRRLHSSAVARAGSQWRLQQGLAANPSGYGPLTELPDWSFADGRPAPPMKGQLRREAQREKLARRVVLLTQEMDAGLQAWKLRQ-QKLQEE-RKQKHDLKPKGTSLRNPLPNQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q86TS9-1", "uniprot_id": "RM52_HUMAN", "id": "Q86TS9-1", "name": "Large ribosomal subunit protein mL52", "aln": "--MAALGTVLFTG----VRRLHCSVAAWAGGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERETFARRVVLLSQEMDAGLQAWQLRQ-QKLQEEQRKQENALKPKGASLKSPLPSQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F658-1", "uniprot_id": "E7F658_DANRE", "id": "E7F658-1", "name": "Large ribosomal subunit protein mL52", "aln": "-MAAALRTVGAAVSRQSVRTFSSTCVTHAGIKWRLENGLPRGGSEYGPLTDLPDWSFADGRPAPLLKGQIRRQKQREEFARRAVYLNAEMDEGMKQWHESEKAKKQKEEDVKSLLLKPKGNLFKQKKK--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7JWG9-1", "uniprot_id": "RM52_DROME", "id": "Q7JWG9-1", "name": "Large ribosomal subunit protein mL52", "aln": "MLKITKICLASSATSTAQRSIALTAPRAIDQKWRAAKGLPENPNAFGPLTNLPDYTYLDGRPTPLGANQKRRLIKQQEIATRIVELSGELEFAKQRHERLKANAESEKQRLIRSKLKPKGHFLLKK----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * : : . :** :**. . . :****:***::: ****:* .* ** ::: :* * * *. *:: . : . : .:: ***** : . ", "identical_positions": 30, "similar_positions": 33, "identity": "23.08%" }, { "cls_id": "homologset.agr.HGNC:16657", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CPT0-1", "uniprot_id": "B2L14_MOUSE", "id": "Q9CPT0-1", "name": "Apoptosis facilitator Bcl-2-like protein 14", "aln": "MCSTSVYDLEDIPLEDDDPNSIEFKILAFYARHHVFKNTPAVFSPKLSRTRSLSQKALGTWST-DSWTQVSLPCRGSPSSEKNISLGKKKSSWRTLFRVAEKEEGLPSSPKEIRAQGPQGPFPVERQSGFHNQHWPRSLSSVEQRLESEVVDSKVACIANRVAEIVYSWPPPDVIHSQGGSKLKERVSEILYFRFEG----PCDSKNKDGEDQIISKIVELLKFSGDQLGREIKKDKALMSSFQDGLSYSTFKTITDLFLRDVDTRGESEVKARGFKAALAIDAIAKLTAIDNHPMNRMLGFGTKYLREYFSPWVQQNGGWEKILGISHEEVD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6AYK4-1", "uniprot_id": "B2L14_RAT", "id": "Q6AYK4-1", "name": "Apoptosis facilitator Bcl-2-like protein 14", "aln": "MCSTSVYDLEDIPLEDDDPNSIEFKILAFYARHHVFKSTPAVFSPKLSRTRSLSQKALGTWST-DSWTQISLPCRDSLSSEKHISLGKKKSSWRTLFRVTEKEEEPPSSPKEIHAQG---PFPVERQG--RNQHWSRSLSSVEQCLESEAVDSKVACIANRVAEIVYSWPPPDDSQSQGGGKFKESVPKILHFELQGPQLRPCDSK-KDGEDQIINRIVELLKYSGDQLGREIKRDKALVSIFQEGLSYSVFRTITDLFLRDVDTRGESEIKAQGFKAALAIDAIAKLTAIDNHPMNRMLGFGTKYLREYFSPWVQQNGGWEKILGLSHEEVD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BZR8-1", "uniprot_id": "B2L14_HUMAN", "id": "Q9BZR8-1", "name": "Apoptosis facilitator Bcl-2-like protein 14", "aln": "MCSTSGCDLEEIPLDDDDLNTIEFKILAYYTRHHVFKSTPALFSPKLLRTRSLSQRGLGNCSANESWTEVSWPCRNSQSSEKAINLGKKKSSWKAFFGVVEKEDS-QSTPAKVSAQG---QRTLEYQDS-HSQQWSRCLSNVEQCLEHEAVDPKVISIANRVAEIVYSWPPPQATQAGGFKSKEIFVTEGLSFQLQGHVPVASSSK-KDEEEQILAKIVELLKYSGDQLERKLKKDKALMGHFQDGLSYSVFKTITDQVLMGVDPRGESEVKAQGFKAALVIDVTAKLTAIDNHPMNRVLGFGTKYLKENFSPWIQQHGGWEKILGISHEEVD", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***** ***:***:*** *:*******:*:******.***:***** *******:.**. *: :***::* ***.* **** *.********:::* *.***: *:* :: *** .:* *. :.*:*.*.**.*** ** *.**.** .***************: :: * . : *.: * *.::* ...** ** *:**: :******:***** *::*:****:. **:*****.*:**** .* .**.*****:**:******.**. *************:********:* ****:**:********:******", "identical_positions": 211, "similar_positions": 73, "identity": "63.36%" }, { "cls_id": "homologset.agr.HGNC:16658", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ERH6-1", "uniprot_id": "MOAP1_MOUSE", "id": "Q9ERH6-1", "name": "Modulator of apoptosis 1", "aln": "MTLRLLEDWCRGMDMNPRKALLVAGIPPTCGVADIEEALQAGLAPLGEHRLLGRMFRRDENKNVALIGLTVETGSALVPKEIPAKGGVWRVIFKPPDTDSDFLCRLNEFLKGEGMTMGELTRVLGNRNDPLGLDPGIMIPEIRAPMLAQALNEALKPTLQYLRYKKLSVFSGRDPPGPGEEEFESWMFHTSQVMKTWQVSDVEKRRRLIESLRGPAFEIIRVLKINNPFITVAECLKTLETIFGIIDNPRALQVKYLTTYQKTDEKLSAYVLRLEPLLQKLVQKGAIEKEVVNQARLDQVIAGAVHKSVRRELGLPEGSPAPGLLQLLTLIKDKE-AEEEEVLLQAELEGYCT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96BY2-1", "uniprot_id": "MOAP1_HUMAN", "id": "Q96BY2-1", "name": "Modulator of apoptosis 1", "aln": "MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQG-MIPEMWAPMLAQAL-EALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**********************:***. :*.**:**************:************::***:***.**. ********.***:*********.*. **.****** *****:***:*.**:.*..*. : * ****: ******** ***:*:** *:**** *****:.* ****** *****:*::*:***.********:*******:::*********:*** ***::** :**: **** *********** :*******************:****::.****************::****.***..****:****.**** * *****.**** *** *", "identical_positions": 271, "similar_positions": 58, "identity": "76.77%" }, { "cls_id": "homologset.agr.HGNC:1666", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q61470-1", "uniprot_id": "CD37_MOUSE", "id": "Q61470-1", "name": "Leukocyte antigen CD37", "aln": "MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFVS--------FVG--LSFVPLQTWSKVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQ----MLKANESEEPFVPCSCYNSTATNDSTVFDKLFFSQLSRLGPRAKLRQTADICALPAKAHIYREGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P31053-1", "uniprot_id": "CD37_RAT", "id": "P31053-1", "name": "Leukocyte antigen CD37", "aln": "MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFVS--------FVG--LSFVPLQTWSKVLSVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQ----MLKANGSEELFVPCSCYNSTATNDSSGFDKLFLSQLSRLGPRAKLRQTADICALPAKAHIYREGCARSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P11049-1", "uniprot_id": "CD37_HUMAN", "id": "P11049-1", "name": "Leukocyte antigen CD37", "aln": "MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVS--------FVG--LAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVL----ILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GUH5-1", "uniprot_id": "A0AC58GUH5_DANRE", "id": "A0AC58GUH5-1", "name": "Tetraspanin", "aln": "-MASECCVSVTKYFLFLFNLVFFLLGSLLLSSGLWMLLSDTSEIKT-------FIDPFRPYISISLLSYLLIISGSVTMSLGFFGCLGSLKTVKFLLAIYFILLTVLLAAQIVGGVLFYTMKTELSKSLGKETD-LIQSFGRN--DSSFKKTMDYIQRQEECCGWNGKEDWGDSIPCSCYHKANETKELCDNCSPDFFYPVLSCKIYDEGCKDKVENWLGSNLHFILWVILAISVVECLQWTCVIFYCCFNRTHRCCPRESHGSHVQLSRFLFVTSVVFLFVTRVFHYCMPR---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V3E5-1", "uniprot_id": "Q9V3E5_DROME", "id": "Q9V3E5-1", "name": "Tetraspanin", "aln": "-MVFDCGVWCAKYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVIGAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITSYSLGENVDATSLMWNQLMGNFGCCGINDYHDFDASP-----AWVNGKGNRTIPDACCILKDVAKLVPRDEDCTTNPS------------------DSNSFYKKGCYEVFTEWLIR-QRELVIVAIAVGIVHLVLIILAFALCKAFAKYNDMRL---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :. : **:* :**:.**:** ::: * *: :.. * : : .:. : :* : * . : :.::* :*::: : **. * :* :*: ::*. * * : .: . * .: . : . : : *** : .*: * . : . . *: : . : . * : .: :: . * ", "identical_positions": 33, "similar_positions": 71, "identity": "11.19%" }, { "cls_id": "homologset.agr.HGNC:16660", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A114-1", "uniprot_id": "D4A114_RAT", "id": "D4A114-1", "name": "", "aln": "MAAYPESCLDANVLNFVADLSLASPRHPFLCEFPPGVPFEDQTLGFREGR--GLLQFEGRYQEVEGGEVDYEDPEEEEEEGEGRGRVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLQ---SKEEKEAS-----------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q923Z4-1", "uniprot_id": "FER3L_MOUSE", "id": "Q923Z4-1", "name": "Fer3-like protein", "aln": "MAAYPESCLDATVLNFVADLSLASPRHPLLCEFPPGVPFGDRTLGYREGRPGRLSQFDERYQEVEGDEVEYEDPEEEEEEGEGRGRVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLQ---SKEEKEAS-----------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96RJ6-1", "uniprot_id": "FER3L_HUMAN", "id": "Q96RJ6-1", "name": "Fer3-like protein", "aln": "MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRG--VSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLE---SCEKKESG-----------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VGJ5-1", "uniprot_id": "FER3_DROME", "id": "Q9VGJ5-1", "name": "Protein Fer3", "aln": "-MQHPHPIDQPTYMPDVPFQPLWGQEAPP----PPIVPYQELIAGFPCTD---LSLWQR-------SQVTPLVPQRPSTNGRANG--SSSSSKKTRRRVASMAQRRAANIRERRRMFNLNEAFDKLRRKVPTFAYEKRLSRIETLRLAITYIGFMAELLSGTPSNSHKSRSDVYGSMNGHHQAPPPAIHPHHLHPAAAYQRDFASPYNHSLS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*.. :.. : *. .* . . * .* *. : . : :: :* :. . : ...* * .: .*:** : ***:*******:**********:************************.**.**:***. * ..*. . ", "identical_positions": 65, "similar_positions": 42, "identity": "30.66%" }, { "cls_id": "homologset.agr.HGNC:16661", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A820-1", "uniprot_id": "A0A8I6A820_RAT", "id": "A0A8I6A820-1", "name": "", "aln": "MAWMTYVSHWFEQDDWYEGLQRATMSQVRQVGLLAAGCQPWNKDVCAANGDRFAYCATLAIYIYQLDHRYNEFRLHAIMAEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQNVIAKLDNIKETPACLSWCWNTGDAVAFVSQKGPLLIWTISGPDSGVSVHKEAHGFVSDICIFRWHTQKKGKVAFGHTDGSISIFQPGSKNQKHVLRPESLEGTDEDDPVTALEWDPLSTDYLLVANLHYGIRLLDSESLYCITTFSFPSAAVSVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDSFKLKKAGFHCLHVVNSPPKRK-FSVQSSNKNHYMSSTSEAVPPPSLTRNQAFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRELGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPGDLNCIAGATSRNGAFIWDIQKGKMIQRFN--EHGKNGIFYIAWSHKDSKRIATCSGDGFCIIRTLDGKLLHKYKHPAAVFGCDWSQNNKDMIATGCEDKHVRVFYVASSSNQPLKVFSGHTARVFHVKWSPLREGVLCSGSDDGSVRIWDYTQDACISILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLIPLITPLQINILADRPWEEIIGNTDNAIEQASPPLLCGKASKDIKQEVEKLTCNPRVKKLRLFSECLSSPGGSDNLWNLVAVIKGQDDSLLPQNYYKGMMHLKHLIKFRTSEAQELTTIKMSKFGGGIGAPTKENKLKEAAEIHLRLGQIQRYCELMVELGEWDKALSVAPGVSVKYWRKLMQRRADQLIQEDKDDVIPYCIATGDVKKLVNFFVSRGQLKEALLVAQAACEGNMQSIHVSTPKGASYPDDVYKEDFNELLHKVINELAEWYFQDGRAVLAACCHLAVDDIELAMAYLIRGNELELAVSVGTVLGEPAAPAMHYALQLLARKCMMIPMCFPSVVYSFPFCYTNRNLAVDLLLMTPDREVHLIKLCAFYPGCIEEINDLHKKCNLPPAEECIQLAETAQADGNVYETIKYYLLSQEPEKALPIGIDFVKGCISNSNWTLDTVHPVLDLMTYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYHSIVPALYEYTSQLLKRRVVSVPLKIEHLSEELDAWRACTQSTKQLSEDSPYVPPSDSQRTVYETLLKRLKEEPLKGITGPDYVTGTNLPSHSDIHISCLNGLKIQGPVYFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9Q271-1", "uniprot_id": "E9Q271_MOUSE", "id": "E9Q271-1", "name": "", "aln": "MAWMTYVSHWFEQDDWYEGLQRATMSQVRQVGLLAAGCQPWNKDVCAANGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWNTHDAVAFVSQKGPLLIWTISGPDSGVSVHKEAHSFASDICIFRWHTQKKGKVAFGHIDGSISIFQPGSKNQKHVLRPDSLEGTDEEDPVTALEWDPLSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNFKLKKTGFHCFHVVNSPPKKK-FSVQSPNKNHYISSTSEAVPPPNLTQNQAFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRELGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPGDLNCIAGATSRNGAFIWDIQKGKIIQRFN--EHGKNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYKHPAAVFGCDWSQNNKDMIATGCEDKNIRVFYVATSSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLIPLITPLQINILADRSWDEVIGNTDNAIRQDCPPLLCGKVSRDIKQEVEKLTCNPRAKKLRLFSECLSPPGGSDNLWNLVSVIKGQDDSLLPQNYCKGMMHLKHLIKFRTSEAQELTTIKMSKFGGGVGAPTKEKKLKEAAEIHLRLGQIQRYCELMVELGEWDKALSVAPGVSVKYWRKLMQRRADQLIQEDKDDVIPYCIATGDVKKLVNFFVSRGQLKEALLVAQAACEGNMQNAHVSTPKGASNSDDIHKEDFNELLHKVINELAEWYFQDGQAVLAACCHLAVDDIELAMAYLIRGNELELAVSVGTVLGEPAAPAMHYALQLLATKCMMIPMCFPSVVYSFPLCYTNRNLAADLLLMTPGSEVHLVKLCAFYPGCIEEINDLHKKCNLPPAEECTQLAETARADGNVFETIKYYLLSQEPEKALPIGIDFVKGCISNSNWTLDTVYPVLDLMSYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYQSIVPSLYEYTSQLLKRRVVSVPLKIEHLSEELDAWRACTQSTKQSSEDSPYTPPSDSQRTVYETLLKRLKEEPLKGITGLDYVTGSNLPSHSDIHISCLTGLKIQGPVYFLEDGKSTISLNDALMWAKVNPFSPLGTGIRLNPF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IZU2-1", "uniprot_id": "WDR17_HUMAN", "id": "Q8IZU2-1", "name": "WD repeat-containing protein 17", "aln": "MAWMTYISNWFEQDDWYEGLQRANMSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSIFHPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLLVVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPRKK-FSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFN--EHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVKKLRWFSECLSPPGGSDNLWNLVAVIKGQDDSLLPQNYCKGIMHLKHLIKFRTSEAQELTTVKMSKFGGGIGVPAKEERLKEAAEIHLRLGQIQRYCELMVELGEWDKALSIAPGVSVKYWKKLMQRRADQLIQEDKDDVIPYCIAIGDVKKLVHFFMSRGQLKEALLVAQAACEGNMQPLHVSVPKGASYSDDIYKEDFNELLHKVSKELAEWYFQDGRAVLAACCHLAIDNIELAMAYLIRGNELELAVCVGTVLGESAAPATHYALELLARKCMMISVCFPCVGYSVPFCYVNRNLAADLLLMIPDNELHLIKLCAFYPGCTEEINDLHDKCKLPTVEECMQLAETARADDNIFETVKYYLLSQEPEKALPIGISFVKEYISSSDWTLDTIYPVLDLLSYIRTEKLLLHTCTEARNELLILCGYIGALLAIRRQYQSIVPALYEYTSQLLKRREVSVPLKIEYLSEELDAWRACTQSTNRSLEDSPYTPPSDSQRMIYATLLKRLKEESLKGIIGPDYVTGSNLPSHSDIHISCLTGLKIQGPVFFLEDGKSAISLNDALMWAKVNPFSPLGTGIRLNPF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AR08-1", "uniprot_id": "A0A8M3AR08_DANRE", "id": "A0A8M3AR08-1", "name": "", "aln": "MESLCWFSSYHSE-------PKIKMSQVKQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYVYQLDHRYNEFKLRAIMSEHKKTITAISWCPHNPEVFASASADNLLIIWNVAEQKAVARLDNTKGIPASLSWCWNAGDSVAFVSHRGPLYIWTVSGPDSGVTVHKEAHSFLSDICLFRWHPLKKGKVVFGHTDGSLSIFQPGSKHQKHVLRPESLEGTDEEDPITALEWDPLSTDYLLVANMHNGIRLLDSESLCCITTFSFPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVSRATPLDNFKLKKTGFHALHVLNSPPAKKSFSSNSPSKNHYTSSTSEAVPPPTLSQNQAFSLPPGHAVCCFMDGGVGLYDMGAKKWDFLRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVVYSLSWAPGDLNCIAGATSRNGAFIWDVKKGKMITRFNELQHGKNGIFCVAWSHKDSKRIATCSGDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDKNVRVYYLATSSDQPLKVFTGHTAKVFHVRWSPLREGILCSGSDDGTVRIWDYTQDACINVLSGHTAPVRGLMWNTEVPYLLTSGSWDYTIRVWDTRDGTCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTPLIAPLVVNILTDHSWDDIIGNTDRAMVPGAPPLLCGKVSRDIKQELDKLSSDVRMKKLRWFSECFSPPGGSHNLWDLVAVINGQDDSLLPQYYGQGIMHMKHLVRFKTSEAQELTIVKMSKFGGGIGAPSKEERLKNAAEIHIRLGQIQRYCELMVELGEWEKALSVAPGVSMKYWKKLMQRRADQLMQEGNDDVIPYCIATGEVKKLVNFFTSRGQLKEAVLVAQGACEGNIHVPQITSINHAANSDNDNIEKYCGMLHRVCKELAEWYFQDGCAVLAGCCHLAVDNTELALASLIRGNELELAVCVGTVLGESASKATHYVLELLARKYMTTATCFPSVAH--------RDLAARLLQMIPDNEILLAKLCAFYPGSSAEINDLHEKCGLPSLEECKELAESAQSEGEIFQAVKYYLLSPEPEKALPIGITYVKEQLSSPDWVVDSVYQILDLLSYIRTDRLILPKCSEERNELLILCGYIGALLAIGRQYSSIVPALYEYTSQLLKRREVAVPLQIEQLSVELEAWRACTQSLK-VADDSLYTSPSEAQKTEYSQILSRIREEPIKGLEGPDYVTGSNLPSHSDVQISCFTGLRIQGPAFFLEDGKSAISLNDALMWAKVNPFSPLGTGVRLNPF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : :.* :..: : .****:*******************.*************:**********:*:***:****************::***.*:***:********:.:*:**. * **.*.****: * *****::*** ***:******* ***:**.* ****:****. :****.*** ***:***:**.*:*******:*******:**:***************.*:* ****:***** *****.:****.********************************:**:*.:****:***.:**:**** :* ** :*..**** **********.*::**********.****:******************:******************:******************************:::******.******.*********:::***:* *** :**.**** :**************.********:***:*****************************.::**:*:*:**:******:****:****:*******:********:***********:. *.**************:**** ********:***** *.*:************************************* .*::*: :***:*:.*:::***** *: *******.*:**:**::**:.: : **** ****:*.****.***:**:**:********* * :*:**:***::*:******** :********:*.*:**::**:*****:******************:****:*****:***:**********:**.:********* *:*****:** ********:****.*****:: ::: : *: .*: *.: :**:* :********** ****.*****:*: ***:* ***********.*******.*: * **.*:*** * * . ***.* : *:**. ** * *. *: * ********. ******.** **. *** :***:*:::.::::::****** ********** :** :*..:*.:*::: :***::****::*:* .*:* ***************** *** ****:************ *:***:** ** **:******** : :** *..**::*: * :*.*::**.:**: * *****:*******::***:.**:****.:*******:*********************:*****", "identical_positions": 963, "similar_positions": 246, "identity": "72.68%" }, { "cls_id": "homologset.agr.HGNC:16663", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BK10-1", "uniprot_id": "CAN13_RAT", "id": "Q5BK10-1", "name": "Calpain-13", "aln": "MAHDTEALEETSVVKFKNQDFRFLRDRCLSRGQLFIDDTFPAEASSIGQKLLMGKRLPKLEWKRP--QDLSFGPPHFILEGASRFDIQQGRAGDCWFLAALGSLTQNPQCLQKILMNQSFSYQYAGIFHFRFWQCGQWVEVVIDDRLPVVGNNFCFVHPRRGNQEFWPCLMEKAYAKLLGSYSQLHYGYLPDALVDLTGGVVTRINLHSSPSDLLMVVKTAVQTGSMVACATPKWLTEESEVMENGLVSQHAYTVTGAEKIQYRRGWEEIIRLWNPWG--NTEWRGRWGDGSQEWWETHGSRKSQLYENKDDGEFWMSCRDFHENFSCLYICSQFPITMDPGVTPNESWRQMRFKNQVISGNTAGGDGRDIQYLFDVQEPMDGNNVIVAFT--VMPQSLKTEEWPFPLQFQVFKVDSQFQKFQKRLPPAFFSQFRDAAQGIDYVTKRNFTKSFHLSPGTYVVVASAHGKEVEFLLRIFLKMPHKDRNPNSSFNLKALKGSLSENESPKSSFHRYMDQGLDIDASQLQSLLNQEYLTGPPGDTFSLDQCQSIMALMDLKVNGRLDREEFARLQSRLIHCQHVFQHIQRSQGVLRSSDLWEVIESTDFLSGVLLSKELLSLMTLRYSDSSGRLSFPSLVCFLIRLETMSKAFRNLSKDGKSIYLTEMEWMKLVMYS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UW68-1", "uniprot_id": "CAN13_MOUSE", "id": "Q3UW68-1", "name": "Calpain-13", "aln": "MAHD----AETSVVKFKNQDFRTLRDHCLSRGQLFIDDTFPAAASSIGEKLLRGKHLSKLEWKRPTSKDLPFYPPHFILEGASRFDIHQGIAGDCWFLAALGSLTQNPQCLQKILMDQSYSHQYAGIFQFRFWQCGQWVEVVIDDQLPVIGDNFLFVHPRGGNKEFWPCLMEKAYAKLLGSYSQLHYGYLPDALVDLTGGVVTIINLHSSPFDLLTTVKTAIQAGSMVACATENGLTEEAKVMENGLVSQHAYTVTGAEKIQYQGRWEDIIRLWNPWG--KTEWKGRWKDGSKEWRETHDPRKSQLYENKEDGEFWMSCQDFQENFSCLFICNQIPITMDHGVTPNESWRQMRFTNQVISRNRAGGHGRDMQYVFSVQEHTAGNNVVVAFT--IMPQSLNTEEERFPLQFQVFKVP-QFQNVQGRLPPAFFSPFRSAAQGTKYVSKCNFTKSFHLNPGTYVVVTTANGKEVEFLLRIFLKMPDKHRDPSSNFNLRALKESLPENGSRNSISYTYMDQGLDIDATQLQSLLNQEFLTGPPGDTFSLDQCQSIMALMDLKVNGRLDQEEFARLRSRLIHCQHIFQSIQRRPGVLLSSDLWKVIENTDFLVGIFISSELLSLMALRYSDSSGRVSFPTLVCFLIRLETMAKAFRNLSKDGKGIYLTETEWMNLVMYS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6MZZ7-1", "uniprot_id": "CAN13_HUMAN", "id": "Q6MZZ7-1", "name": "Calpain-13", "aln": "MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRP--QDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAG--SQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDSDRHLSSHFNLR-MKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEMEWMSLVMYN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: ***::***:*** ***:*** *: * *:**** ****:*** *:*.:: **** :**. ******:. *****:** *.**************** ***** **:*:******:****************:*** *:: **:** *:******:************:****:* **********:* *:***** **: .**** ::**:::*** . *: ::.******* *********:***: **:** ****** ::**:*** ***:** ** ..*****:::::********:**:::* .::**.::***:* * * :*.* *: * :*** * *** .* *: *.*** *.**:*..* : *..*::*: ***:***: . *..: ::**.*** **.:.*. . : *** ::**.**.****: :. *..***********...*. .* ***: :* * .*: * :* * :* *****:***.***** ******* ****:*:*::***:********:****** .**:* **:** :* *** *****:.**.**** *:::* *** *::****** **:***:*****:***:*:*:*********.:**** ***.****.", "identical_positions": 412, "similar_positions": 150, "identity": "61.13%" }, { "cls_id": "homologset.agr.HGNC:16664", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M6Z1T3-1", "uniprot_id": "A0A8M6Z1T3_DANRE", "id": "A0A8M6Z1T3-1", "name": "", "aln": "--MPPPVVPHGMCLKVMNDRNMKGGMGSDTNPLKFMDQDYNFLQDYCLKTRQRFVDEFFPPDLRSIG--EGLLKPEVMARVEWIRPTKLYPEAAEFVVDTVSRFDYAQG-FIGNCWFLASVGALTFQSKLLQKVVPDGQSLRHNYTGLFHFRFWRFGKWFDVVIDDKLPTINR-QLIFVKSKTYNEFWPALLEKAYAKVCGSYADMHTGRVSEALLDFTGGVHMHYDLKTAPTDLWEIMYRASQSEVLMGCESPAG---NEERLPNGIVLGHAYTVTKVYQVMSGRNPVQLVRLFNPWGDSEWNGDWSDNSPLWNTVDDEDRKQ-LLVSDNGEFWMSMKDFLRTFDNMDICCNCPDFLEGKSACKWTSKSHNGSW----------VPGSTAGG-CMNHPDTFCTNPQFWLRINEMDKTCDQGQ--NNVLVSLIQKPDKRNRRLAQHHGIGFCVFAVPPEMRSEGKFRSSFFN-RKPVVTSGNFQDARQVMKFFRLEPGEYLIVPSTYLPNKNADFILSILCKNDIQIQKDTERTEKDFLVDLIGVSESGCTEKEDEESKTKFLFRQYSDQYKVVDAEKLQQILHENLLRGRKNAEGFG-LDSCRSMIAMSDFCVTGRLQGSEFVRLWDRITTYRDIFYNMDSSKDGVLSLNELQNALEKTGLHLNEDILNLMVVRYGGASEQISLEGFICLVMRLNCMASIFQKLCENGK-ISLDESEWIGLTMYS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB40ECQ1-1", "uniprot_id": "A0AB40ECQ1_DANRE", "id": "A0AB40ECQ1-1", "name": "", "aln": "--MPPPNN----CHHNPNE----DEVDSLTSPLYFLDQNYQELQQKCLTESTLYSDELFPPDNSSIGLFDEVPPEVDMSQIVWKRPSELVSDP-NLIVDDVSRFDYAQGSVLGNCWFLASIGALTFEKDIMKQVLPAEQSFTKDYAGIFHFRFWRFEKWIDVVIDDQLPTIDD-ELLFVCSKTSNEFWPALLEKAYAKVCGSYADLNAGFISEALMDFTGGTHMYYTLSSAPADLWKIMECAFISKTLIGCGSNSEGSPEENELLHGIIADHAYTVTGVFEVISEENPVQLVRLLNPWGEEEWQGDWSDESPLWETVCEEARKCCREVLNDGEFWMSMEDFTRLFESIDICCLCPDFLDGSSDCHWTSKRHFGRWNAEKFMYNTFIHHLTAGG-DIIKTETFWKNPQFRVTIDELNEDCASGQRPENILVSLMQNHEKRNRNSQENYDIGFYVFEMR---HQNERFAMEFFADREPVAHTDDLVWLREVMKFFRLEPGEYLIVPCTKNPGETASFVLSVFSKHETHLEQIQETTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A8MX76-1", "uniprot_id": "CAN14_HUMAN", "id": "A8MX76-1", "name": "Calpain-14", "aln": "MSLWPPFR----CRWKLAP------RYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIG--SGSLLQKLPPRLQWKRPPELHSNP-QFYFAKAKRLDLCQG-IVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSG----EKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWE----------KRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLR-PCSVLVSLLQKPRHRCRKRKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNSGVVFS------------KEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIYLQKPEWMMMALYS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ** * * . :*::: * ** : * **. *** . .:: * **.:* .:. :: . ..*:* .** .:*:*****:: **::...::.:*:* **: ..*:*:*:* **:: :*. *****:**. : :*:** *. * ** *********:.*** *:::* :****:*****. * * * :**.*: * ...*:** : : *: * :*:: .****:* : :* . ..* **:* ****. **:*****.*. *: : : : ::*****:::** * : ** *.:*. .: :** . : * * **** :** .**** : : . :: . : .:****:*: :* *. *** :: : .: :: .** . *: .. : ::* : : **** *****. . :.:.*:* ::.::. : : ", "identical_positions": 165, "similar_positions": 153, "identity": "22.73%" }, { "cls_id": "homologset.agr.HGNC:16665", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R0R3-1", "uniprot_id": "APEL_RAT", "id": "Q9R0R3-1", "name": "Apelin", "aln": "MNLSFCVQALLLLWLSLTAVCGVPLMLPPDGKGLEE-GNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0R4-1", "uniprot_id": "APEL_MOUSE", "id": "Q9R0R4-1", "name": "Apelin", "aln": "MNLRLCVQALLLLWLSLTAVCGVPLMLPPDGTGLEE-GSMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9ULZ1-1", "uniprot_id": "APEL_HUMAN", "id": "Q9ULZ1-1", "name": "Apelin", "aln": "MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLED-GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q4TTN8-1", "uniprot_id": "APEL_DANRE", "id": "Q4TTN8-1", "name": "Apelin", "aln": "MNVKILTLVIVLVVSLLCSASAGPMASTEHSKEIEEVGSMRTPLRQNPARAGRSQRPAGWRR-RRPRPRLSHKGPMPF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: : . .::*: * :... .: ... :*: *.:* :: . :* * . .* *: ** ************", "identical_positions": 25, "similar_positions": 27, "identity": "32.05%" }, { "cls_id": "homologset.agr.HGNC:16666", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WV04-1", "uniprot_id": "KIF9_MOUSE", "id": "Q9WV04-1", "name": "Kinesin-like protein KIF9", "aln": "MGTRKKVQAFVRVRPTDDFAHEMIKYGEDNKSIDIHLKKDTRRGVVNNQQTDWSFKLDGVLHNASQDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMTGATENYKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNENLFDLLSTLPYVGPSVTPMTIVENPQGIFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYMEAHSRTLSDEKYITSKINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIALGDQNRDHVPFRQSKLTHALKDSLGGNCNMVLVTNIYGEAAQLDETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQELAIHDSLSNRTLVNYDPMDEIQIAEINSQVRRYLEGTLDEIDIINLRQIQEVFNQFRVVLSQQEQEVESALRRKYTLIDKNDFAAISAVQKVGLMDIEGNLVGEPDGQSFGLGVAPFSVKPGKKPKTKKTPKDQFSSSARKEGASSPVSGKDFDVASISKTQLIPSSKDGDLKDMLARERETSSIEPLISDSPKEELRAPRPSTPPSRTVAFEEFKNERGSEINRIFKENKSILNERKKRASETTQRINAIKQEIDETKDALNFQKSLREKQGEYENKGLMIIDEEEFLLILKLKDLKKQYRNEYQELRDLRAEIQYCQRLVDQCRHRLLMEFDIWYNESFMIPEDVQVALKLGSSIRPGMVPISRIVCLGEDDQDRFSHLQQTVLPEGLDSITFYNAKVKTDQKHNYMKTMVGLQQSHRK------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A8G1-1", "uniprot_id": "D4A8G1_RAT", "id": "D4A8G1-1", "name": "Kinesin-like protein", "aln": "MGTRKKVQAFVRVKPTDDFAHEMIKYGEDNKSIDIHLKKDTRRGAVNNQQTDWSFKLDGVLHDASQDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMTGATENYKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNENLFDLLSTLPYVGPSVTPMTIVENPQGVFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYMEAHSRTLSDEKYITSKINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIALGDQNRDHIPFRQSKLTHALKDSLGGNCNMVLVTNIYGEAAQLDETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQELAIHDSLSNRTLVNYDPMDEIQIAEINSQVRRYLEGTLDEIDIINLRQIQEVFNQFRVVLSQQEQEVESALRRKYTLIDKNDFAAISAVQKAGLMDVEGHLVGEPDGQSFGLGVAPFSVKPGKKSKTKKTTKDQFSSSARKEGASSPVSGKDFDMTSISKTQLIPSSKEGDLKDMLVRERETSSIEPLPSDSPKEESRALRPSTPPSKPVAFEEFKNERGSEINRIFKENKSILNERKKRASETTQRINAIKQEIDVTKEALNFQKSLREKQGEYENKGLMIIDEEEFLLILKLKDLKKQYRNEYQELRDLRAEIQYCQRLVDQCRHRLLMEFDIWYNESFVIPEDVQVALKLGSSIRPGMVPITRIVCLGEDDQDRFSQLQQTVLPEGPDSISFYNAKVKTEQKAYGKSDQHGSRTTWWRAACFSVLKQRRTGLDERYGIPFRP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9HAQ2-1", "uniprot_id": "KIF9_HUMAN", "id": "Q9HAQ2-1", "name": "Kinesin-like protein KIF9", "aln": "MGTRKKVHAFVRVKPTDDFAHEMIRYGDDKRSIDIHLKKDIRRGVVNNQQTDWSFKLDGVLHDASQDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENYKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENPQGVFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYLEAHSRTLSEEKYITSKINLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLEQAIIALGDQKRDHIPFRQCKLTHALKDSLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQELAIHDSLTNRTFVTYDPMDEIQIAEINSQVRRYLEGTLDEIDIISLRQIKEVFNQFRVVLSQQEQEVESTLRRKYTLIDRNDFAAISAIQKAGLVDVDGHLVGEPEGQNFGLGVAPFSTKPGKKAKSKKTFKEPLSSLARKEGASSPVNGKDLDYVSTSKTQLVPSSKDGDVKDMLSRDRETSSIEPLPSDSPKEELRPIRPDTPPSKPVAFEEFKNEQGSEINRIFKENKSILNERRKRASETTQHINAIKREIDVTKEALNFQKSLREKQGKYENKGLMIIDEEEFLLILKLKDLKKQYRSEYQDLRDLRAEIQYCQHLVDQCRHRLLMEFDIWYNESFVIPEDMQMALKPGGSIRPGMVPVNRIVSLGEDDQDKFSQLQQRVLPEGPDSISFYNAKVKIEQKHNYLKTMMGLQQAHRK------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*******:*****:**********:**:*::********* ***.*****************:*************.************************** *******************************************.**************************:************************************************:********:*******************.*:****:*************************:***:****.*****************************:***************************************************:***:*.******************************.****:*******************:*********:********:**.**:*::*:*****:**.*********.*****.*:*** *: :** **********.***:* .* *****:****:**:**** *:********* ******* *. **.****:.*********:******************:********:*****:*** **:*************:****************************.***:************:*********************:****:*:*** *.********:.***.*******:**:*** ***** ***:******* :** . * : : : ", "identical_positions": 688, "similar_positions": 75, "identity": "84.52%" }, { "cls_id": "homologset.agr.HGNC:16667", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VEK0-1", "uniprot_id": "CC50A_MOUSE", "id": "Q8VEK0-1", "name": "Cell cycle control protein 50A", "aln": "--------MAMNYSAKDEVD--GGPAGPPG---------------GAAKTRRPDNTAFKQQRLPAWQPILTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLS-------------------------------PNVTSCACTINFTLKQSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGD----PSALLNPSKECEPYRRNED--RPIAPCGAIANSMFNDTLELYLVANESDPKPIPIPLKKKGIAWWTDKNVKFRNPPGKE-SLEEKFKDTIKPVNWHKAVYELDPEDESNNGFINEDFIVWMRTAALPTFRKLYRLIERR-DDLHPTLPAGQYFLNITYNYPVHSFDGRKRMILSTISWMGGKNPFLGIAYITIGSISFLLGVVLLVINHKYRNSSNTADITI-----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6AY41-1", "uniprot_id": "CC50A_RAT", "id": "Q6AY41-1", "name": "Cell cycle control protein 50A", "aln": "--------MAMNYSAKDEVD--GGPTGPPG---------------GAAKTRRPDNTAFKQQRLPAWQPILTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIE-------------------------------------------------------------------GNVFMYYGLSNFYQNHRRYVKSRDDSQLNGD----PSALLNPSKECEPYRRNED--KPIAPCGAIANSMFNDTLELFLVANESDPKPVPILLKKKGIAWWTDKNVKFRNPPGKD-SLQEKFKDTTKPVNWHKPVYELDPDDESNNGFINEDFIVWMRTAALPTFRKLYRLIERT-DDLHPTLPAGQYYLNITYNYPVHFFDGRKRMILSTISWMGGKNPFLGIAYITIGSISFLLGVVLLVINHKYRNSSNTADITI-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NV96-1", "uniprot_id": "CC50A_HUMAN", "id": "Q9NV96-1", "name": "Cell cycle control protein 50A", "aln": "--------MAMNYNAKDEVD--GGPPCAPG---------------GTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLS-------------------------------PDVTPCFCTINFTLEKSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGD----SSALLNPSKECEPYRRNED--KPIAPCGAIANSMFNDTLELFLIGNDS--YPIPIALKKKGIAWWTDKNVKFRNPPGGD-NLEERFKGTTKPVNWLKPVYMLDSDPD-NNGFINEDFIVWMRTAALPTFRKLYRLIERK-SDLHPTLPAGRYSLNVTYNYPVHYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHKYRNSSNTADITI-----------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1PEQ2-1", "uniprot_id": "A0A8M1PEQ2_DANRE", "id": "A0A8M1PEQ2-1", "name": "Cell cycle control protein", "aln": "-------MMASSYNAKEEDGHHSGTAGLGG---------------TAIRTRKPDNTAFKQQRLPAWQPILTAGTVLPAFFVIGLIFIPIGIGLYVTSNNIKEFEIDYTGTDMSSPCFNCSQS---------------------------FSWNSTTPCKCTLSFSLDQPFESNVFMYYGLSNFYQNHRRYVKSRDDSQLNGD----ERSLKEPSKECEPYRINDN--KRIAPCGAIANSMFNDTLDLFYIDPNG--TKTQIPMIKKGIAWWTDKHVKFRNPGGNNPNLTAVFIDTAKPINWRKPVYELD-TDPENNGFINEDFIVWMRTAALPTFRKLYRIIQKK-NNMTPTLPRGNYSLEVTYNYPVRSFEGRKRMILSTISWMGGKNPFLGIAYITVGSICFFLGVVLLFIHHKYGNRNNSSDIPS-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1QEI3-1", "uniprot_id": "F1QEI3_DANRE", "id": "F1QEI3-1", "name": "Cell cycle control protein", "aln": "-------MMASSYNAKEEDGHHPGLVGSGGP--------------GAVKSKKPDNTAFKQQRLPAWQPILTAGTVLPAFFMIGLIFIPIGIGLFVTSNNIKEFEIDYTGVDMSSPCYNCAQN---------------------------YSWNSTSVCTCTVPFTLDQPFESNVFMYYGLSNFYQNHRRYVKSRDDSQLNGD----KSSLLNPSKECEPYRTSDR--KPIAPCGAIANSLFNDTLELFYIHPNG--SKIGIHLVKTGIAWWTDKHVKFRNPGGSNNNLSVVFQDTSKPVNWRKAVYELDPADPENNGFVNEDLIVWMRTAALPTFRKLYRIIQKKKDTMTPTLPPGNYSLEVAYNYPVRSFDGRKRVILSTISWMGGKNPFLGIAYITVGSVCFFLGVVLLIIHHKYGNRNNNADIPN-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VXG0-1", "uniprot_id": "Q9VXG0_DROME", "id": "Q9VXG0-1", "name": "", "aln": "--------MSTQQAENEES--------------------------AAAKSKRPSDSAFKQQRLPAWQPVLTARTVLPTFFVIGVLFIPIGVVLLHLSNTANELIIDYTKCRRSGGNTTCAEY---------------------------LEANPGVTCPCEVPFVLPSDFNGVVYMYYGLTNYYQNHRRYVKSRDDEQLLGH----LS--QTPSTDCAPFAYDPDSGKPIAPCGAIANSLFNDTLTLLQG-------GSEIKLLKTGIAWPSDKRVKFRNP---EGNLNVSLEGFSKPIFWQKGLADLDPENPDNNGFQNEDLIVWMRTAALPSFRKLYRRLNQTNTNYANGLKSGNYTLNIKYNYPVVSFDGTKRMILSTTSVLGGKNPFLGIAYIVVGAICITLGLALLFIHMRCS-RSNMEMINVNPHTQYS----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53740-1", "uniprot_id": "YN8S_YEAST", "id": "P53740-1", "name": "Phospholipid-transporting ATPase accessory subunit CRF1", "aln": "--------MGLILRWKEKKQLSSKQNAQ--------------------KSRKPANTSFRQQRLKAWQPILSPQSVLPLLILMACVFAPIGIGLVVSTISVQRLVVNYTECDALAPAKHFETIPSEYVDYHFSKKVAV--QPQWMVLTDPE----LGNQTCRIQFEVPNHIKKSTYVYYRLTNFNQNYREYVQSLDLDQLKGK----ALIGNDLDPNCDPLRTVEN--KTIFPCGLIANSMFNDTFGTTLTGVND--TAD-YLLTTKGIAWDTDSHR--------YGKTEYNASDIVPPPNWAKLFPNGYTDDNIPDLQNWEQFKIWMRTAALPNFYKLAMKNETN------GLGKGIYIADIELNYPVRSFYGTKSFVLTTNSIIGAGNEALGIVYLIVAGIATLFAILFLIKVIFKPRPMHDHSYLNFENSDTP-FDESSVVSIPLREIL", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P25656-1", "uniprot_id": "CDC50_YEAST", "id": "P25656-1", "name": "Phospholipid-transporting ATPase accessory subunit CDC50", "aln": "----------MVSLFKRGKAPPLTKEGP--------------------TSKKPPNTAFRQQRLKAWQPILSPQSVLPLLIFVACIFTPIGIGLIVSATKVQDLTIDYSHCDTKASTTAFEDIPKKYIKYHFKSKVEN--KPQWR-LTENE----NGEQSCELQFEIPNDIKKSIFIYYKITNFYQNHRRYVQSFDTKQILGE----PIKKDDLDTSCSPIRSRED--KIIYPCGLIANSMFNDTFSQVLSGIDD--TED-YNLTNKHISWSIDRHR--------FKTTKYNASDIVPPPNWMKKYPDGYTDENLPDIHTWEEFQVWMRTAAFPKFYKLTLKNESA------SLPKGKYQMNIELNYPISLFGGTKSFVLTTNGAIGGRNMSLGVLYLIVAGLCALFGIIFLVKLIFQPRAMGDHTYLNFDDEENEDYEDVHAENTTLREIL", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P42838-1", "uniprot_id": "LEM3_YEAST", "id": "P42838-1", "name": "Phospholipid-transporting ATPase accessory subunit LEM3", "aln": "MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATS-SWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADG-KIYYPCGLIANSMFNDTFPLQLTNVGD--TSNNYSLTNKGINWESDKKR--------YKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKND------TLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK-------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .::* : :* **** * :*:*:. :*** :.:. :* :* : . . :: * : :: *:*.** * . .*: *. . .* * : *** ****:****: : .. * * * . . * * * : *:: ***..*: .: ** : * * * :: ::*: * * * . *: . :*. * **: *: . :. :.: :* ", "identical_positions": 62, "similar_positions": 69, "identity": "13.75%" }, { "cls_id": "homologset.agr.HGNC:16668", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZE02-1", "uniprot_id": "D3ZE02_RAT", "id": "D3ZE02-1", "name": "", "aln": "MEFDLAAALGPGSKKP-EGAGQVGDPKHCPLKAPGRPEAGAAHKPRHGPGGSSDSSSSSSSSSSSDSEAEGKAHAAGCKKHERSSDKAKKPKVKK-ERKKKEK-----TPH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9GZP8-1", "uniprot_id": "IMUP_HUMAN", "id": "Q9GZP8-1", "name": "Immortalization up-regulated protein", "aln": "MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQG-----HHSSSDSSSSSSDSDTDVKSHAAGSKQHESIPGKAKKPKVKKKEKGKKEKGKKKEAPH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.*** * *:** ***: **** .* *. **.****. *::* . ***.********::: *:****.*:** ..********* *: **** :**", "identical_positions": 64, "similar_positions": 21, "identity": "57.66%" }, { "cls_id": "homologset.agr.HGNC:16669", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P0C673-1", "uniprot_id": "IGS11_MOUSE", "id": "P0C673-1", "name": "Immunoglobulin superfamily member 11", "aln": "MTRRRSAPASWLLVSLLGVATSLEVSESPGSVQVARGQTAVLPCAFSTSAALLNLNVIWMVIPLSNANQPEQVILYQGGQMFDGALRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDRGGRNIGVTGLTVLVPPSAPQCQIQGSQDLGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRSVGVIAGAVGTGAVLIVICLALISGAFFYWRSKNKEEEEEEIPNEIREDDLPPKCSSAKAFHTEISSSENNTLTSSNTYNSRYWNNNPKPHRNTESFNHFSDLRQSFS---GNAVIPSIYANGNHLVLGPHKTLVVTANRGSSPQVLPRNNGSVSRKPWPQHTHSYTVSQMTLERIGAVPVMVPAQSRAGSLV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5U2P2-1", "uniprot_id": "IGS11_RAT", "id": "Q5U2P2-1", "name": "Immunoglobulin superfamily member 11", "aln": "MTRRRSALASWLLLSLLGVAASLEVSESPGSVQVARGQTAVLPCAFSTSAALLNLNVIWMVIPLSNANQPEQVILYQGGQMFDGALRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDRGGRNIGVTGLTVLVPPSAPNCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRSVGVIAGAVGTGAVLIVICLALTSGAFFYWRSKNKEEEEEEIPNEIREDDLPPKCSSAKAFHTEISSSENNTLTSSNTYNSRYWNNNPKPHKNTESFNHFSDLRQSFS---GNAVIPSIYANGNHLVLGPHKTLVVTANRGSSPQVMPRNNGSVSRKPWSQHTHSYTVSQMTLERIGAVPVMVPAQSRAGSLV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5DX21-1", "uniprot_id": "IGS11_HUMAN", "id": "Q5DX21-1", "name": "Immunoglobulin superfamily member 11", "aln": "MTSQRSPLAPLLLLSLHGVAASLEVSESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQPEQVILYQGGQMFDGAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTVLVPPSAPHCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYWRSKNKEEEEEEIPNEIREDDLPPKCSSAKAFHTEISSSDNNTLTSSNAYNSRYWSNNPKVHRNTESVSHFSDLGQSFSFHSGNANIPSIYANGTHLVPGQHKTLVVTANRGSSPQVMSRSNGSVSRKPRPPHTHSYTISHATLERIGAVPVMVPAQSRAGSLV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :**. *. **:** ***:**********:******.*****:*:*****:******** *********************** ***************************************** *******************:********:*********************************************************************************.:*:****:*****:*::*:** ********************************************:********:******.**** *:****..***** **** *** ********.*** * ****************:.*.******** . ******:*: **********************", "identical_positions": 378, "similar_positions": 33, "identity": "87.7%" }, { "cls_id": "homologset.agr.HGNC:1667", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P56528-1", "uniprot_id": "CD38_MOUSE", "id": "P56528-1", "name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "aln": "MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTKHFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHWSENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVHKLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSCRLNT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q64244-1", "uniprot_id": "CD38_RAT", "id": "Q64244-1", "name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "aln": "MANYEFSQVSEDRPGCRLTRKAQIGLGVGLLLLVALVV-VVVIVLWPRSPLVWKGKPTTKHFADIILGRCLIYTQILRPEMRDQDCKKILSTFKRGFISKNPCNITNEDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYDSCPHWSENCPNNPVAVFWNVISQKFAEDACGVVQVMLNGSLSEPFYRNSTFGSVEVFNLDPNKVHKLQAWVMHDIKGTSSNACSSPSINELKSIVNKRNMIFACQDNYRPVRFLQCVKNPEHPSCRLNV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P28907-1", "uniprot_id": "CD38_HUMAN", "id": "P28907-1", "name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "aln": "MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQ---WSGPGTTKRFPETVLARCVKYTEIH-PEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** *** ** *:* ***:*:**: ***.:*:*: :** **: :. *.* ***:*.: .*.**: **:* ****. :*:.: .:** .*:**:*****.*** **:** ***:**** *:**: *.****:* :* .***********:**** ***: .**.:** ***.* ::*.***::***:.:*::*** **.**:****** : * :*********..*:*:**:.*:***:*. . * : *...:::**: *:.***: *:* : *** :*********..** : ", "identical_positions": 166, "similar_positions": 86, "identity": "54.61%" }, { "cls_id": "homologset.agr.HGNC:16672", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08663-1", "uniprot_id": "MAP2_MOUSE", "id": "O08663-1", "name": "Methionine aminopeptidase 2", "aln": "MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKK-KKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQ---DGRTAAWRTTSEEKKALDQ--ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRK-------LIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P38062-1", "uniprot_id": "MAP2_RAT", "id": "P38062-1", "name": "Methionine aminopeptidase 2", "aln": "MAGVEEASSFGGHLNRDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAGQQELDKESGTSVDEVAKQLERQALEEKEKDDDDEDGDGDGDGAAGKKKKKK-KKKRGPRVQTDPPSVPICDLYPNGVFPKGQECEYPPTQ---DGRTAAWRTTSEEKKALDQ--ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRK-------LIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P50579-1", "uniprot_id": "MAP2_HUMAN", "id": "P50579-1", "name": "Methionine aminopeptidase 2", "aln": "MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKK-KKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQ---DGRTAAWRTTSEEKKALDQ--ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRK-------LIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A5WVX8-1", "uniprot_id": "A5WVX8_DANRE", "id": "A5WVX8-1", "name": "Methionine aminopeptidase 2", "aln": "---MEANGLPVPPVMDTLIVNGERE-----AEDPAKKKKRKKKKNKSVVSAGHSEQVDDG---ELEVKKPLEQQNLEEKEREEDGEEDGEEADNTSGKKKKKKPKKKKGPKTQTDPPSVPICDLYPSGVFPVGQECEYPPSQ---DGRSAAWRMSDEEKRVLDE--ANEEMWSDFRQAAEAHRQVRRYVKSWIKPGMTMIDICERLEACSRR-------LIKEDGLNAGLAFPTGCSLNNCAAHYTPNAGDPTVLRYDDVCKIDFGTHINGRIIDCAFTVTFNPKFDHLLEAVADATNTGIKCAGIDVRLCDVGESIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMDCSHYMKNFDVGHVPIRLPRAKHLLNVVNENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIIDPYPPLCDTKGSYTAQFEHTILLRPTCKEVVSRGDDY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VL89-1", "uniprot_id": "Q9VL89_DROME", "id": "Q9VL89-1", "name": "Methionine aminopeptidase 2", "aln": "-----------MSATETLNVEAATP----EIGEEVKKQKKPKPNNKKLR---------------QEAAAKIASGEGGDEELTTNGDAKPATPAAQPAKKKGNK-GKKSG---QTDPPTIPIAKLYPDGNFPEGEIVEHPTPKDMPDDRTAKDRFTSEEKRALDR--INTDIYQELRQAAEAHRQTRQYMQRYIKPGMTMIQICEELENTARR-------LIGENGLEAGLAFPTGCSLNHCAAHYTPNAGDPTVLQYDDVCKIDFGTHIKGRIIDCAFTLTFNNKYDKLLQAVKEATNTGIREAGIDVRLCDIGAAIQEVMESYEIELDGKTYPIKAIRNLNGHSISPYRIHAGKTVPIVKGGESTRMEEDEFYAIETFGSTGRGLVHDDMDCSHYMKNFDLPFVPLRLQSSKQLLGTINKNFGTLAFCKRWLDRAGATKYQMALKDLCDKGIVEAYPPLCDIKGCYTAQYEHTIMLRPTCKEVVSRGDDY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38174-1", "uniprot_id": "MAP2_YEAST", "id": "P38174-1", "name": "Methionine aminopeptidase 2", "aln": "-------------------------------MTDAEIENSP--------------------------ASDLKELNLENEGVEQQDQAKADESDPVESKKKKNKKKKKKK------SNVKKIELLFPDGKYPEGAWMDYHQDFN-------LQRTTDEESRYLKRDLERAEHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAENLLAMEDPKSQGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: :. : :: :.: .*** :* ** . * *:*.* :* * :: * :.**.: *.. : :.:.*:.** **:.*: : * ***.:::*.: :* :*: * *: . *:.**** ***:****:****** ***:*:*: *:*:*.::.*.***.***::*: ::* ** ** :** ***: ******* *:* :*********:*::*:** :*. *** ****. ****.**:*****.*::*:***.* :*********:* * . : *** :. : * * :*:** .::.*****.**:*:*** * ** :**::* *::: **** * *.****:****:*:. *****:****", "identical_positions": 183, "similar_positions": 112, "identity": "37.27%" }, { "cls_id": "homologset.agr.HGNC:16673", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIE0-1", "uniprot_id": "AN32E_RAT", "id": "Q5XIE0-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "aln": "MEMKKKINMELKNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEEED-EDGDEDEEDEEEDEAGPPEGYEDE-----------DEDEDEAGSEVGEGEEEVGLSYLMKEEIQDEEDDDDYVDEGEEEEEEEEEGPRGEKRKRDAEDDGEEDDD---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P97822-1", "uniprot_id": "AN32E_MOUSE", "id": "P97822-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "aln": "MEMKKKINMELKNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDDDEDGDEDEEDEDEDEAGPPEGYEEEE----------DDDEDEAGSEVGEGEEEVGLSYLMKDEIQDEEDDDDYVDEGEEEEEEEEEGLRGEKRKRDAEDDGEEDDD---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BTT0-1", "uniprot_id": "AN32E_HUMAN", "id": "Q9BTT0-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "aln": "MEMKKKINLELRNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDE--DGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NUW5-1", "uniprot_id": "AN32E_DANRE", "id": "Q6NUW5-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "aln": "MEMKKRISLELRNRTPAEVAELVVDNCRSSDGEIEGLTDDFKELEFLSMVNVGLTSLAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDLFNCEITTLEDYRESIFELLPQVTYLDGFDAEDNEAPDSEADDDD------DDEDGDEG-AGQLGEYEEE------------EEEDEEGSEGGE----VGLSYLMKEDIQDEEDDDDYVEEEEEEGGEEEADVRGEKRKREAEDEGEDDDEDDD------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V895-1", "uniprot_id": "AN32A_DROME", "id": "Q9V895-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "--MEKRIELERRARKVNQITELNLDNCRSTS--IVGLTDEYTALESLSLINVGLTTLKGFPKLPNLKKLELSDNRISSGLNYLTT-SPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYREKIFKMLPSLNFLDGFDCNDEEVQ-SDGDDDDEVNGNDSDEVGVSDEDDDSDDSDEE------------ANGEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEEEDSDIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHDG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:*:*.:* : * :::** :*** . . * **.* :. ** **: ** *::* :*.* :*:******* **. *: *: ..:* **********:*.*::.*:::*** ***** : * :::***.**::* .:.:***** :*:*. *: :::: .:* .. . ::* : : ** : . * :: .***::: : : : :* : :.::.*.:.::.: ", "identical_positions": 83, "similar_positions": 88, "identity": "29.75%" }, { "cls_id": "homologset.agr.HGNC:16674", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZVW8-1", "uniprot_id": "D3ZVW8_RAT", "id": "D3ZVW8-1", "name": "", "aln": "MGCRNSKISSANTAVLGVIQIMIGIYHVLMWYFLLLLYMGQIKGVFGTYEPLTYKMGTSLWGLTFVLSGAFTIKAAKYRSRFMLLCTMSLNILCIIVTIIAASLTIVELSHFRSVSYRNYGQAKLGREVSRILLCSYPLEFVVALTYSISGCAYL---------------------------MET--QDENSESVTEVVEDNF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5FWC3-1", "uniprot_id": "M4A13_MOUSE", "id": "Q5FWC3-1", "name": "Membrane-spanning 4-domains subfamily A member 13", "aln": "MECRNPKVSSANITVLGVIQIMIGIYHVLMWYFLLLLYMGQIKGVFGTYEPVTYKMGTSLWGFAFVISGAFTVKAAKYQSRHMILCTMSLNILCIIITIVAASLTIVELSHFRSVSYRNYGQAKLGREVSRVLLCSYPLEFAIALLYSISSCAYLPLSSIVKSLVRKTWRLSSLAAWRQMIWLEAGNQEETLESVTEVVEGNS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5J8X5-1", "uniprot_id": "M4A13_HUMAN", "id": "Q5J8X5-1", "name": "Membrane-spanning 4-domains subfamily A member 13", "aln": "---------------------MIGIFHIFMWYFLLVLYMGQIKGAFGTYEPVTYKTGCTLWGIFFIIAGVFLIRVTKYPTRSGIISTLIINIICIITTITAVTLTIIELSHFNSVSYRNYGQAKLGREVSRILLFFYGLEFSIALTHSIYSCSNLFR------------------------------RQNDLTSVTEEAESTP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ****:*::******:********.******:*** * :***: *:::*.* ::.:** :* ::.*: :**:*** ** *.:***:*****.******************:** * *** :** :** .*: * ::: **** .*.. ", "identical_positions": 90, "similar_positions": 38, "identity": "44.33%" }, { "cls_id": "homologset.agr.HGNC:16675", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P49911-1", "uniprot_id": "AN32A_RAT", "id": "P49911-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "MEMDKRIYLELRNRTPSDVKELVLDNCRSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAP-DSDVEGYVE--DDDEE---DEDE---EEYDEYAQLVEDEEEE---DEEEEGEEE---DVSGEEEEDEEGYNDGEVDDEEDEEDAAEEEGSQKRKREPDDEGQEDD------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35381-1", "uniprot_id": "AN32A_MOUSE", "id": "O35381-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "MEMDKRIYLELRNRTPSDVKELVLDNCKSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAP-DSDVEGYVE--DDDEE---DEDE---EEYDEYAQLVEDEEEE---DEEEEGEEE---DVSGEEEEDEEGYNDGEVDDEEDEEEAGEEEGSQKRKREPDDEGEEDD------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43423-1", "uniprot_id": "AN32C_HUMAN", "id": "O43423-1", "name": "Putative uncharacterized protein ANP32CP", "aln": "MEMGRRIHSELRNRAPSDVKELALDNSRSNEGKLEALTDEFEELEFLSKINGGLTSISDLPKL-KLRKLEL---RVSGGLEVLAEKCPNLTHLYLSGNKIKDLSTIEPLKQLENLKSLDLFNCEVTNLNDYGENVFKLLLQLTYLDSCYWDHKEAP-YSDIEDHVEGLDDEEE---GEHE---EEYDEDAQVVEDEEGE---EEEEEGEEE---DVSGGDEEDEEGYNDGEVDGEEDEEELGEEERGQKRK-----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZUP0-1", "uniprot_id": "AN32A_DANRE", "id": "Q7ZUP0-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "MDMKKRIHLELRNRTPSDVKELVLDNCRSNEGKIEGLTDEFEELEFLSTINVGLTSVTNLPKLNKLKKLELSDNRISGGLEVLAGKCPNLTHLNLSGNKIKDLSTIEPLKKLESLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDKEDKEAP-DSDAEAYVEGLDDEDD---EEDEGEEEDYDEDAAPGEEDEEEGEEDDEEEGEEEEEEDISGEEEEEEE-LNDGEVDDEEDFE----EERGLKRKRELDEEGEEDDD-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V895-1", "uniprot_id": "AN32A_DROME", "id": "Q9V895-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "--MEKRIELERRARKVNQITELNLDNCRSTS--IVGLTDEYTALESLSLINVGLTTLKGFPKLPNLKKLELSDNRISSGLNYLTT-SPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYREKIFKMLPSLNFLDGFDCNDEEVQSDGDDDDEVNGNDSDEVGVSDEDD-DSDDSDEEAN-GEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEEEDSDIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHDG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :** * * * .::.** ***.:* . : .****: ** ** ** ***::..:*** :*:**** *:*..*: *: .*:* :* *********.*::**::::.* ***** :.*::: * *::**:* .: :**. :.:*. .* : *: *.:: *.: :: ** * * . * :: **.:.: : .. :*::** : .:.*.: : . : . . : ", "identical_positions": 82, "similar_positions": 85, "identity": "30.6%" }, { "cls_id": "homologset.agr.HGNC:16676", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O95626-1", "uniprot_id": "AN32D_HUMAN", "id": "O95626-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member D", "aln": "MEMGKWIHLELRNRTPSDVKELFLDNSQSNEGKLEGLTDEFEELELLNTINIGLTSIANLPKLNKLKKLELSSNRASVGLEVLAEKCPNLIHLNLSGNKIKDLSTIEPLKKLENLESLDLFTCEVTNLNNY---------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZUP0-1", "uniprot_id": "AN32A_DANRE", "id": "Q7ZUP0-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "MDMKKRIHLELRNRTPSDVKELVLDNCRSNEGKIEGLTDEFEELEFLSTINVGLTSVTNLPKLNKLKKLELSDNRISGGLEVLAGKCPNLTHLNLSGNKIKDLSTIEPLKKLESLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDKEDKEA---PDSDAEAYVEGLDDEDDEEDEGEEEDYDEDAAPGEEDEEEGEEDDEEEGEEEEEEDISGEEEEEEELNDGEVDDEEDFEEERGLKRKRELDEEGEEDDD---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q64G17-1", "uniprot_id": "AN32C_MOUSE", "id": "Q64G17-1", "name": "Putative acidic leucine-rich nuclear phosphoprotein 32 family member C", "aln": "MEMDKQIYLELWNRTPSDVKELVLDSCKSIEGKIEGLTDEFEELEFLSTINVGLTFISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIELLKKLENLKSLDLFNC-----------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9V895-1", "uniprot_id": "AN32A_DROME", "id": "Q9V895-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "--MEKRIELERRARKVNQITELNLDNCRSTS--IVGLTDEYTALESLSLINVGLTTLKGFPKLPNLKKLELSDNRISSGLNYLT-TSPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYREKIFKMLPSLNFLDGFDCNDEEVQSDGDDDDEVNGNDSDEVGVSDEDDDSDDSDEEANGEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEEEDSDIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHDG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * * ** *. .::.** **..:* . : *****: ** *. **:*** : .:*** :*******.** * .*: *: ..*:* :***********.*:: *::::.* ****. ", "identical_positions": 59, "similar_positions": 34, "identity": "22.18%" }, { "cls_id": "homologset.agr.HGNC:16677", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EST6-1", "uniprot_id": "AN32B_RAT", "id": "Q9EST6-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "aln": "MDMKRRIHLELRNRTPAAVQELVLDNCKANDGKIEGLTDEFVNLEFLSLINVGLFSVSDLPKLPKLKKLELSENRIFGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDLFGCEVTNRSDYRETVFRLLPQLSYLDGYDREDQEAPDSDVEVDSVEEAPDSDGEVDGVDKEEEDEEGEDEEEEEDEDGEEEED--EDEEDEDEDEDVEGEDDEDEVSGEEEE--FGHDGEVDEDEEDEDEDEDEEEEESGKGEKRKRETDDEGEDD-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EST5-1", "uniprot_id": "AN32B_MOUSE", "id": "Q9EST5-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "aln": "MDMKRRIHLELRNRTPAAVRELVLDNCKAMDGKIEGLTDEFVNLEFLSLISVGLFSVSDLPKLPKLKKLELSENRIFGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDLFGCEVTNRSDYRETVFRLLPQLSYLDGYDREDQEAPDSDVEVDSVEEAPDSDGEVDGVDKEEEDEEGEDEEEEEDEDGEEEED--EDEEDEDEDEDVEGEDDEDEVSGEEEE--FGHDGEVDEDEEDEDEDEDEEEEESGKGEKRKRETDDEGEDD-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92688-1", "uniprot_id": "AN32B_HUMAN", "id": "Q92688-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "aln": "MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPD-------------SDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEE---FDEED-DEDEDVEGDEDDDEVSEEEEE--FGLD------EEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q4N7-1", "uniprot_id": "F1Q4N7_DANRE", "id": "F1Q4N7-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member", "aln": "MDMKKRIHLELRNRTPSDVRELVLDNCRSNEGKIEGLTAEFVNLEFLSLINVGLLSVSNLPKLGKLKKLELSDNRISGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDHLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDLDDREASD-------------SDGEVDGVD-DDDDEEGEDEDEEEDFDEEEDE-------DDDEDE-VEGEEDDEDGSGEDEEEDFGQDGEVEDDEEDDDDDDDEEEEQGAKGEKRKREADDEDDEDDEEDD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V895-1", "uniprot_id": "AN32A_DROME", "id": "Q9V895-1", "name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "aln": "--MEKRIELERRARKVNQITELNLDNCRSTS--IVGLTDEYTALESLSLINVGLTTLKGFPKLPNLKKLELSDNRISSGLNYLTTS-PKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYREKIFKMLPSLNFLDGFDCNDEEVQSDG----------DDDDEVNGNDSDEVGVSDEDDDSDDSDEEANGEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEE----EDSDIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHDG-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::**.** * *. : ** ****:: . * *** *:. ** ****.*** ::..:*** :*******:*** .**: *: . *.* :******::**:.**:**:.:. * ****. :.*: .:***.:*::**.*.:***:* :*.*. . .* **:* * :: . ..**::.::. : : * : * :* .. :.::: . *:** * : * ::. . : :. .***. *:: .... ", "identical_positions": 95, "similar_positions": 93, "identity": "33.81%" }, { "cls_id": "homologset.agr.HGNC:16682", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZAN8-1", "uniprot_id": "D3ZAN8_RAT", "id": "D3ZAN8-1", "name": "Transcriptional regulator Kaiso", "aln": "MESRKLISATDIQYSASLLNSLNEQRGHGLFCDVTVIVEDRKFRAHRNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRADLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTVQDGTAETLPSSSNDKSPEIEKSKDEAQDNGAPVMPIITESFSLSAEDYEMKKIIVTDSDDDDDDDVIFCSEILPAKEDLPSNNTATQVQPNPASVAISEVTPCTSSNSPPVTNITPPQ-LPTPVNQSTLSQAQGSEELLVSSASTHLTPNIILLNQAPLTAPPSVSSSLPNHMSSSVNVLVQNQQAPNSAV-TGNKA--EEEEEILDDDDDIISSSPDSAVSNTSLVPQADASKSTTFDGSLTQKMQAPILPQEPPSNSLKISDVITRNTNDPG-LRSKHVMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDGGEAK-----LENELPKTSGSEP-SNKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYQCRYCDKVFPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSG-----DSK--LYRLHPCKSLQIRQYAYLSNKPSAMPVMKDDAVGYKVDAGKEPPVGTTSAPPQNKSTFWEDIFIQQEND--------SIFKQNVTDGSTEFEFIIPESY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BN78-1", "uniprot_id": "KAISO_MOUSE", "id": "Q8BN78-1", "name": "Transcriptional regulator Kaiso", "aln": "MESRKLISATDIQYSASLLNSLNEQRGHGLFCDVTVIVEDRKFRAHRNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKVVRVRADLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTEQDGTAETLPSSSSDKSLDMEKSKDEAQDNGATVMPIITESFSLSAEDNEMKKIIVTDSDDDDDDDVIFCSEILPAKEDLPSNNTATQVQPNPASVAISEVTPCASNNSPPVTNITPTQ-LPTPVNQATLSQTQGSEELLVSSASTHLTPNIILLNQAPLTAPPSASSSLPNHMSSSVNVLVQNQQTPNSAVLTGNKA--EEEEEIIDDDDDIISSSPDSAVSNTSLVPQADNSKSTTLDGSLTQKMQIPVLPQEPPSNSLKISDVITRNTNDPG-LRSKHVMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDGGEAK-----LDNELPKTSGSEP-PNKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYQCRYCDKVFPLAEYRTKHEIHHTGERRYQCLTCGKSFINYQFMSSHIKSVHSQDPSG-----DSK--LYRLHPCKSLQIRQYAYLSNKSSAMPVMKDDAVGYKVDAGKEPPVGTTSTPPQNKSTFWEDIFIQQEND--------SIFKQNVTDGSTEFEFIIPESY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86T24-1", "uniprot_id": "KAISO_HUMAN", "id": "Q86T24-1", "name": "Transcriptional regulator Kaiso", "aln": "MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNGATIMPIITESFSLSAEDYEMKKIIVTDSDDDDDD-VIFCSEILPTKETLPSNNTVAQVQSNPGPVAISDVAPSASNNSPPLTNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHLTPNIILLNQTPLSTPPNVSSSLPNHMPSSINLLVQNQQTPNSAILTGNKANEEEEEEIIDDDDDTISSSPDSAVSNTSLVPQADTSQNTSFDGSLIQKMQIPTLLQEPLSNSLKISDIITRNTNDPG-VGSKHLMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDEGEAR-----LENEIPKTSGSEM-ANKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSG-----DSK--LYRLHPCRSLQIRQYAYLSDRSSTIPAMKDDGIGYKVDTGKEPPVGTTTS-TQNKPMTWEDIFIQQEND--------SIFKQNVTDGSTEFEFIIPESY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5A9-1", "uniprot_id": "A0ACD6B5A9_DANRE", "id": "A0ACD6B5A9-1", "name": "", "aln": "MSKLKLISVVDTQYPGSLLKNINDERHNGLFCDVTIVVQDRKFRAHKCVLSASSTYFRQLFSVAGKVVELNFIKADIFDMVLNYIYTSQMFRVRSDRLEDLINAGQILGVTFIANLAIPLAQVKGLPGLSKDGDNNIVSSP-------------EKPEDGGVNMPIITETFSLSAEEFNMTGAN-TEKEDSDSDDVLFV-----------SKTEAPQAQKTKISDVHKNIEGTPETKKQKVTNEEGVA------SKSSIPQEKKSSERNAS-LQNNLDPDVVILSST-----ENSSSILTSPVGTGSN---SNPKPP---------------------------ACPDSVPSDPQNVSLP--SDNIEVLGVQKKKVLLEHSPDHP--GKITLSDVRSSCSSSNGPTNVIPALSVKKTITLDKASEIDSLSPGCKVYANIGENTYDIVP-VKDDPGEGAAPGCKSQIQPDSPNTASLSPKSKKKFKPDQEDHYEIIMDGKTFFVCIVCKRPYVCLTSLRRHFNTHSWERKYPCHYCNKVFALAEYRTKHEISHTGERRYQCLLCNEMFLNYQILSTHCKQAHNQDPSGRKEKDDSANNLYRLLPCKTVQFKPYSFVSDESGGSPVIGEDGTIQYVNSEKEHCTNQPLPSNQSKALNWDDIFVESEGQNARPAPPPQPVDQINAPARNEFEFVIPETY", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.. ****..* **..***:.:*::* :*******::*:*******: :********:*******:****.**:*:** :*****:*::.***:* *::**::**:***.***:*.:**:***.:.* :** : :.. * ::*. ******:******: :*. *:.:*.*.* *:* *:. ..*.* . . . .:: ...:. :** .::::.* : *.: .* .:* *::::*..: . ** *.. : :. * .* :.* :.***. *:.. *. . *.. . * :*: :.* ..:.:**: : :.. * :. :* ****.*:**:.**.**********:***** *****. * * :: : *:*:. . .:*::* .::****:*:**:.:::******.************ ****:** *:**:***.********** ********** *.: *:***::*:* *..*.***** ** **** **:::*:: *:::*:... *.: :*. *:: ** .. . . *.*. *:***::.*.: . ..* : . .****:***:*", "identical_positions": 271, "similar_positions": 212, "identity": "38.94%" }, { "cls_id": "homologset.agr.HGNC:16683", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LLW9-1", "uniprot_id": "A0ABK0LLW9_RAT", "id": "A0ABK0LLW9-1", "name": "OTU domain-containing protein 7B", "aln": "MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDIIQ---EKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKDSAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSESQ-APLAQPESPTASAGDEPRSTPESGESDKESVGSSSISN---------------------------------EGSRRKEKSKRDREKDK----KRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPK-PGGLGSGSGISSGTETLEKKKKNNALKSWKGGKEEAAGD-GPVSEKPTS-EPVGNGGSKYSQEVMQSLSILRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQK-EAERKIMNGGLVSGPPPAKKPEP-------DGGEDQPSDSPAES---KATGFS-PGYPGGFTIPR---------PSGGGVHCQE----PRRQLAGG--PCVGGLPSYATFPRQYPPGRPYSHQDSIP-SLEPG---KDGVHRGALLPPQFRVADS-------YSNGYREP-----------PEPDGWAGAPRGLPPTQT-KCKQPNCSFYGHPETNNFCSCCYREELRRREREPGGELLAHRF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "B2RUR8-1", "uniprot_id": "OTU7B_MOUSE", "id": "B2RUR8-1", "name": "OTU domain-containing protein 7B", "aln": "MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDVIQ---EKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSMDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALRRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGSNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKESAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASIILSLEVKLHLLHSYMNVKWIPLSSDSQ-APLAQPESPTASAGDEPRSTPESGESDKESVGSSSLGN---------------------------------EGSRRKEKSKRDREKDK----KRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPK-PGGLGSGSGISSGTETLEKKKKNNTLKSWKGGKEEAAGD-GPVSEKPPS-ESVGNGGSKYSQEVMQSLSTMRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQK-EVERKIMNGGLVSGPPPAKKPEP-------DGGEDQPSDSPAEP---KAMAFS-TAYPGGFTIPR---------PSGGGVHCQE----PRRQLAGG--PCVGGLPSYATFPRQYP-GRPYPHQDNIP-ALEPG---KDGVHRGALLPPQFRVADS-------YSNGYREP-----------PEPDGWAGAPRGLPPTQT-KCKQPNCSFYGHPETNNLCSCCYREELRRREREPGGELLAHRF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6GQQ9-1", "uniprot_id": "OTU7B_HUMAN", "id": "Q6GQQ9-1", "name": "OTU domain-containing protein 7B", "aln": "MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQ---EKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQ-APLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSN---------------------------------EGGRRKEKSKRDREKDK----KRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSK-PGGVGTGLGGSSGTETLEKKKKN-SLKSWKGGKEEAAGD-GPVSEKPPA-ESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQK-EAERKIMNGGIGGGPPPAKKPEP-------DAREEQPTGPPAES---RAMAFS-TGYPGDFTIPR---------PSGGGVHCQE----PRRQLAGG--PCVGGLPPYATFPRQCPPGRPYPHQDSIP-SLEPGSHSKDGLHRGALLPPPYRVADS-------YSNGYREP-----------PEPDGWAGGLRGLPPTQT-KCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B591-1", "uniprot_id": "A0A8M2B591_DANRE", "id": "A0A8M2B591-1", "name": "ubiquitinyl hydrolase 1", "aln": "MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLSAALSDFEQLRQVHAGSLSCSFVEES------EYPSIEKEMARTGRPLLHRQDEAVQAATEKRLSRGISHASSTIVSLARSHVSSTG---GTNEQLLDTPLCTFQLPDLTVYRDDFRGFIERDLIEQSMMVALEQAGRLNWWTRLGTGCQSLLPLATSGDGNCLLHAASLGMWGFHDRDLMLRKSLYALMDHGQEREALKRRWRWQQTMQNKESGLVYTEEEWQKEWNELLKLASSEPRIHYSTNGSS--GAESQEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPANKCHRSPLVLAYDQAHFSALVSMEQKDSSKEQVVIPLTDSDHKMLPLHFAVDPGADWEWGKDDNDNVMLASVTLSLEAKLHLLHCYMTVTWLPLPCEVQQAPLAQPESPTASAGEDARTPPDSGESDKESVSSSSNGNGDSSTTGTSGTTGKTSGGSSSSSSSSSNSSGGTTGTIGKEKGKKDKEKDKDKDKKRADSVANKLGSFGKSLGSKLKKNVGGLMPGKNASGTGGKQEGQEKKKGSLRGRKGSKDSSPSIQTGSEDSGKGSPSSTSERQNGGYSSESDPFKYSSDVKVSLSILRSAMQGERKYIFSALLTTSNRQPFQEEMIQRYLVDAEERFHAEQEQRREAERKAAGGLASTTGPQMKKDGPELSYRGFESKEEVTDSSPPNFNALKSSSFSPVMYSGVVPIPRHTFIDHSPSPMTQHLHMHHGYMDTRRQLAGGSPSSYPGLPSYATLPRHCPLAQGPPHAQYHPPSASLGSPSRIITPCLTSFPQEHDPTDYPSEPSGAYTNGLRDLRSTLDSRNGPMPVRHYSLGSAGGLANLQSSKCRTPTCNYYGHPETGNYCSYCYREELKRRETEP----AIHRF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********************************:.***************.*. .* * * ::* :*. **:*:***: :* *************:***********.* *:.*: *: *:*:*********.:***.***********:************. :.. .* ******:**********************:***:*****::* *:***:******** ***********:*********:********:* .:**:. *.**.********************:***********************************.:************************:.:***.*******::*:********** .*******.*** ***: ****.******.**.*.*:**..: * **************::.*:.*:**:******.*** .* * ***.*:*:**** ***************:********:**** .*... .** * ..*: .* .*: : . .*.::.. *. ...**: . . .. ***.:* *** :* ***** *:** . *. .:*: :********* ****** ***:*: *.*** .* * ** * :. *: . ..*.: :: .** *.* ..*** * :* :. .******* .. ***.***:**: * .: .* : * : . * : : :* . :* *:** *: * . *. **. *: **: *.*.:******.* ** ******:*** ** ***", "identical_positions": 530, "similar_positions": 169, "identity": "56.68%" }, { "cls_id": "homologset.agr.HGNC:16684", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D1H8-1", "uniprot_id": "RM53_MOUSE", "id": "Q9D1H8-1", "name": "Large ribosomal subunit protein mL53", "aln": "----MAAALARLG--------------LRPVKLVRVQFCPFEKNVESTRTFLQTVSSEKVRATNLNCSVIADVRHDGSEPCVDVLFGDG-------YRLIMRGAHLTTQEMLSALASHIRDRNAAAASA------PGADKVAPGTSTRR------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96EL3-1", "uniprot_id": "RM53_HUMAN", "id": "Q96EL3-1", "name": "Large ribosomal subunit protein mL53", "aln": "----MAAALARLG--------------LRPVKQVRVQFCPFEKNVESTRTFLQTVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDG-------HRLIMRGAHLTALEMLTAFASHIRARDAAGS----------GDK--PGADTGR------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z9J6-1", "uniprot_id": "A1Z9J6_DROME", "id": "A1Z9J6-1", "name": "Large ribosomal subunit protein mL53", "aln": "MSVPFSGALRRSGGIVSAIGKQLKSVNLKGVKRITVQFDPFAENVKSTREFLFLLSTPKVAATNPKCVVKPEIVCDRQPANIKFALIDSAQEQAQVKEIRFNSDNLNTLELLQLCNKHVSSLAPREEITNKVLTKAEKQKLAGGAGGGKKATKKK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::.** * * *: ** : *** ** :**:*** ** :*: ** :** :* * .:: * . . :.. : *. .: :.. :*.: *:* .*: . :* *:. : ", "identical_positions": 34, "similar_positions": 37, "identity": "21.94%" }, { "cls_id": "homologset.agr.HGNC:16685", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z9K2-1", "uniprot_id": "D3Z9K2_RAT", "id": "D3Z9K2-1", "name": "Large ribosomal subunit protein mL54", "aln": "MAAASLLGATRVWARWHPRALPVPGRPGELFIREYAKKAVSKG---GKGGVAAEALKDPEVCTDPSQLTTHAMGVNIYKEGQEVALKPDSEYPTWLF-QVDLGPPKKLEDLEPESREYWRLLRKQNIWRHNRLSKNKKL---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CPW3-1", "uniprot_id": "RM54_MOUSE", "id": "Q9CPW3-1", "name": "Large ribosomal subunit protein mL54", "aln": "MAAAHLLRASRVWARWHPRALPVLRRPGGFSIREYAKKPVGKG---GKGGVAAEALKDPEVCTDPTQLTTHAMGVNIYKEGQDVALKADSEYPTWLF-QVNLGPPKKLEELEPESREYWRLLRKQNIWRHNRLSKNKKL---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6P161-1", "uniprot_id": "RM54_HUMAN", "id": "Q6P161-1", "name": "Large ribosomal subunit protein mL54", "aln": "MATKRLFGATRTWAGWGAWELLNPATSGRLLARDYAKKPVMKGAKSGKGAVTSEALKDPDVCTDPVQLTTYAMGVNIYKEGQDVPLKPDAEYPEWLF-EMNLGPPKTLEELDPESREYWRRLRKQNIWRHNRLSKNKRL---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LXI5-1", "uniprot_id": "RM54_DANRE", "id": "Q1LXI5-1", "name": "Large ribosomal subunit protein mL54", "aln": "MAHTVLQPFKRINLPVLNAYNNLFCNTFLVQTRSYAKKPVFKG--KGKGMVK-EVLKGPEVCKDPAKLCTYAVGVNVFKQGEDPTIKPKDEYPEWLF-QLNLGPVKQLNELEPDSWEYWRRIRKEHIWRHNKLNKGKKM---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W2M8-1", "uniprot_id": "Q9W2M8_DROME", "id": "Q9W2M8-1", "name": "Large ribosomal subunit protein mL54", "aln": "-----MTSLTAVFQMARQRLIAPAIGNWARFYAAKPAAPAGKKKKLGKLGPIMEKKVIP-VETDANKLVNYVCGSNYMKTGEDIKIKPDSEYPDWLW-TLNTEGIVPLDELDPNSKQYWRRLRKLALRRNNQLSKLKKF---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36532-1", "uniprot_id": "RM37_YEAST", "id": "P36532-1", "name": "Large ribosomal subunit protein mL54", "aln": "--------------MLARSLGYRLISTSRILYNKPTVKSVVSS------------------CPAGTSLN-----LNIWKSGKDAVALEDKEYPNWLWSVLDSDHVVEHAAEDPEGQALLKRRKNIRKANRQRIKQNNFLSQL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. . .* * * *:: . *** **: :: :*:. : :: ..:::.: : : ", "identical_positions": 10, "similar_positions": 26, "identity": "7.04%" }, { "cls_id": "homologset.agr.HGNC:16686", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CZ83-1", "uniprot_id": "RM55_MOUSE", "id": "Q9CZ83-1", "name": "Large ribosomal subunit protein mL55", "aln": "-MPLAILLSLLRHCGVRAALPTPRHLHTSPWRADCSRASLTRLRRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPLDLDALSPEERRARFRKREAQLQQKREEEPEVVDSFDTERYKQFWTKTKK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZF99-1", "uniprot_id": "D3ZF99_RAT", "id": "D3ZF99-1", "name": "", "aln": "-MPLGSLLGLLRHCGVRAAFPAPCHLHTSPWRADCSRASLTRLRRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPLDLDALSPEERRARFRKREAQLQQKREEEPEMVDSFDTERYKRFWTKTKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7Z7F7-1", "uniprot_id": "RM55_HUMAN", "id": "Q7Z7F7-1", "name": "Large ribosomal subunit protein mL55", "aln": "MAAVGSLLGRLRQSTVKATGPALRRLHTSSWRADSSRASLTRVHRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPIDLDTLSPEERRARLRKREAQLQSRKEYEQELSDDLHVERYRQFWTRTKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VE04-1", "uniprot_id": "RM55_DROME", "id": "Q9VE04-1", "name": "Large ribosomal subunit protein mL55", "aln": "-----MLLKQLPQ--------AVQQIRCIS----SATTAVTRLHRSVYCRLYPTVVVQPDGSTINIRYHEPRKIIKLPLDLSTLTDAERRARLEAR--KPRKKVKIMEEVEDNFNAKKYMKYIKKK--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * : : ::: . .: :::**::*..*.****.::*: *****:***:***::: :*:**.:*: *****:. * : :.: : *: *.:..::* :: .:. ", "identical_positions": 36, "similar_positions": 49, "identity": "28.12%" }, { "cls_id": "homologset.agr.HGNC:16687", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A9M0-1", "uniprot_id": "A0A8I6A9M0_RAT", "id": "A0A8I6A9M0-1", "name": "", "aln": "MATGVAGLERCKKIVHQEAMEKRSVDETENGDAFLDLKKLPTSK----SPHRYTKEELLDIKERPYSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVES-LKKEPESDRPSLVRRIADPRERVKED-DLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARAFEKDHRLSDKDLRDLRDRDRERDYKDKRFRREFGDSKRVFGERR-----------RNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVREGIVECNGGVAEEDEVEVILAQEPSADQEVPRDVILPEQSPGEFDFNEFFNLDKVPCLASMIEDVLGEG--SVSASRFSRWFSNPSRSGSRS-SSLGSTPHEELERLAGLEQAVLSPGQNSGNYFAPIPSEDH----AENKVDILEMLQKAKVDLKPLLS---SLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQIKNSTPFMAEHLEETLSAVTSNRQLKKDGDMTAFNKLVNTMKASGTLPTQPKVSRNLESHLLAPAEIPGQPVPKNILQELLGQPVQRPASSNLLSG---------LMGSLEPTASLLSQRAPSPPMSQVFRTQAASADYLHPRIPSPIGFPSGPQQLLGDPFQGMRKPMSPVTAQMSQLELQQAALEG---LTLPHDLAVQTTPFYQPG----FSKPQVDR-----TRDGLRNRQQRMTKSPAPMHRGNSS--SPAPAASITSMLSPS---FTPTSVIRKMYESREKSKEEIAPGTVVPGDGKEDAQKASEENLLSSNSISNSDQDSSPTANPKLSTLQRSSCSTPLSQTNRYTKEQDYRPKAAGRKTPTLASPVPGTPFLRPTHQVPLVPHVPIVRPAHQLHPGLVQRLIAQGVHPQHLPGLLQAGVLPPGIDIAPLQGLSGPLLGQPLYPLVSAASHPLLNPRPGTPLHLAVMQQQLQRSV----------------------------------------LHPPGSSSQAAAINVQT-PPNVPSRSGLPHMHSQLEHR-------------TSQRSSSPVGLAKWFGSDVLQQP------LPSMPT-KVISVDELEYRQ------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EST3-1", "uniprot_id": "4ET_MOUSE", "id": "Q9EST3-1", "name": "Eukaryotic translation initiation factor 4E transporter", "aln": "-------------------MEK-SVAETENGDAFLELKKLPTSK----SPHRYTKEELLDIKERPYSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVES-LKKESESDRPSLVRRIADPRERVKED-DLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARAFEKDHRLSDKDLRDLRDRDRERDYKDKRFRREFGDSKRVFGERR-----------RNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPSADQEVPRDVILPEQSPGEFDFNEFFNLDKVPCLASMIEDVLGEG--SVSASRFSRWFSNPSRSGSRS-SSLGSTPHEELERLAGLEQAVLSPGQNSGNYFAPIPSEDH----AENKVDILEMLQKAKVDLKPLLS---SLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQMKNSTPFMAEHLEETLSAASSNRQLKKDGDMTAFNKLVNTMKASGTLPTQPKVSRNVESHLLAPAEIPGQPVSKNILQELLGQPVQRPASSNLLSG---------LMGSLEATASLLSQRAPSPPMSQVFRTQAASADYLHPRIPSPIGFPSGPQQLLGDPFQGMRKPMSPVSAQMSQLELQQAALEG---LALPHDLAVQTAPFYQPG----FSKPQVDR-----TRDGLRNRQQRMSKSPAPMHGGNSS--SPAPAASITSMLSPS---FTPTSVIRKMYESREKTKEEMAPGMVVPGDGKEDTQKTSEENLLSSNPIPNTDQDSS-TTNPKLSTLQRSSCSTPLSQTSRYTKEQDYRPKTAGRKTPTLASPVPGTPFLRPTHQVPLVPHVPIVRPAHQLHPGLVQRLIAQGVHPQHLPSLLQAGVLPPGIDMAPLQGLSGPLLGQPLYPLVSAASHPLLNPRPGTPLHLAVMQQQLQRSV----------------------------------------LHPPGSSSQAAAISVQT-PQNVPSRSGMPHMHSQLEHR-------------TSQRSSSPVGLAKWFGSDVLQQP------LPSMPT-KVISVDELEYRQ------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NRA8-1", "uniprot_id": "4ET_HUMAN", "id": "Q9NRA8-1", "name": "Eukaryotic translation initiation factor 4E transporter", "aln": "-------------------MDRRSMGETESGDAFLDLKKPPASK----CPHRYTKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVES-LKKELDTDRPSLVRRIVDPRERVKED-DLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERR-----------RNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEG--SVSASRFSRWFSNPSRSGSRS-SSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDH----AENKVDILEMLQKAKVDLKPLLS---SLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSG---------LMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEG---LALPHDLAVQAANFYQPG----FGKPQVDR-----TRDGFRNRQQRVTKSPAPVHRGNSS--SPAPAASITSMLSPS---FTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLP-AASHPLLNPRPGTPLHLAMVQQQLQRSV----------------------------------------LHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHR-------------PSQRSSSPVGLAKWFGSDVLQQP------LPSMPA-KVISVDELEYRQ------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8IH18-1", "uniprot_id": "4ET_DROME", "id": "Q8IH18-1", "name": "Eukaryotic translation initiation factor 4E transporter", "aln": "-------------------MDTSKISARYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKNRLSPEADNSSLICSNSSSISSRR-AMRNRERANNYYQRFVPTDSLLISGE-DKDKDALSHGQPYKLNIIDHRSISSSHLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRKGSELDTAETCLNFVQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDYKNEKTVEASIENEKETSPNGSGSTSSLNQHNQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFSTQSRSK--RGNSYLIHEEPEWFSAGPKSQLET----IDLHGFEDLEKNEERSVTEDKNNQIQQLDKNLDAQASKDEASMRNSNDSLNFREVIPSDEK----KHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQNPESEFNFDAFLNMHPLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAANNNEFPGFRESHAQEKRGIPSVKDLEAQMIKVDMRTDLINPIAGSLCQTVQMEKPIARDTEAFKKLLQQLGSQARQHH---------PCN-DDCRTINLSNIANHVHLESKLHQKINDGHLQQPELSVNVPTMPTSSHVFLQKRLEIQHLIQRLHCGDVSHDFLEKELDNPSTPAATKDVIATVLNEYSHS----KRNPVVTGDPNIFTQQSFLQPQSVHQHYSQELHSQNTA--NHTINQLISHGNSPTPLAFTPTSVLRKMTADKDTQ-----SPSTYCQNPQYHVHQQNAKQVGTRENVLEPQLTATMAVQPRM-ILGGGNFAIGQNNQHLSPNMSQSRNQQVLKWTSGNMQMVHGKTFGRPILKGGLN----SMPHSNSALPFTAHKIEMQPIHQPHLQQQQHRFKAVQSVESNLNTESVHQNITSPVGWHQLYMQHQQQHHHTRQQLSQRVIYGEMHR------------------------------------------QSNPQMSPPVPGFSDSSDSGNVIKANSLTSPSYQRDER-------------ISSPTN---QLAQWFSPELLAKAS--AGKLPLLNVNQALSLEEFERSIQHSSGVVHN---------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VMA3-1", "uniprot_id": "CUP_DROME", "id": "Q9VMA3-1", "name": "Protein cup", "aln": "-------------------MQMAEAEQENGAGALKIATNAGATDRPAHQQLPLPVEDQQDEVLTPAEKGKFEYPPPPPPPTPVQAPLATKATALNASQEHDDDEANSEKWEDPCAPPPPPPLPTSAFLATGLGYLKLPAFKLKDALEKAITKLEANKRTLKASPESSRSIKNKNVVALEMLPRRSNPETIGDGSMLASTSTAVMLQTKKPAVIVEMERRCKIINLLAKQNQILESISGEAIPMHGPSKHLHEDEGLTLQVLSARASTPYTQPSSMLSCTAVSCDLEHDSPRKQVASKEAVPEQQSSQVQQKRPPSTGIHKPGSLRAPKAVRPTTAPVVSSKPVKSYTRSRLMDIRNGMFNALMHRSKESFVMPRIATCDDIELEGRLRRMNIWRTSDGTRFRTRSTTANLNMNNNNNNECMPAFFKNKNKPNLISDESIIQSQPPQPQTEFQDPAIVNQRRIGSGRLNHSKWGYNDEDYHSYHNGKSQHMEEVNSKNSKNMTVLQFFDNGEISSQPQRRPNTPVMGMSINRSENDTLHSNESSEDLSRANENYVKRVMSGFLVVSKPKSRDVEDRHHRRYRNQNEEPEWFSCGPTSRLDTIELCGFDEDEEKMLKEGNKNHGLGETERETSKQKMDHKYKWTHAEPMGRSKYMPKHDTNNNHNVENMNNVMATEHQQQKEEKRPGSGRSFQFDKFNQSQQNYESSSYVNHQQPPQTQPQQMQQQSNTNTNNSKFMSFFANEGNSSSSSLNEFFKQAINQGHGNNPEQPKSLGHIGQMPSVDQLEAKWRRNSLNNVGETANKQTDNFQKLIGSLSSAKPQSQAVGYDAISNFIMQQQQYQQQQQKQHLIIQQQQQHTAFLASLQLKAILGRADTQLLLLRLTKGEISKHGLLVQLANPRLTDMDREAITAVLQFTNTQQQQQQHKQQLDMLSSTVIASQLQNLHNLAIVQQTLAARQQPQHNPQTQAPHQLSQEDLQAHANVIMRNAVMKRKIEEQTSKLINGGAKHQAQQQYLNRGQQRQARPDANSNALLHALISGGGNNHASGYPMNGQPQKHHSNLRFGDNQNFQSFESNQPHFATQYKQQYQQSQQQHPHQQPQQLNSLHQNNAGAVNSFNKAQMQAQSAISMLPNSGDEFH", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: . . : : : . * ::: :. . : : : . . . : . .. . . . . * . : :. . .. .: ... . . . . . .: : * : * . : . : : . :.: . : : . : . .. . . .: : : : .::. : .:: . . * . .* : ..: .: ... :.... .:. . : . :: .. . .. . . . : . . : :: . : : : . . . . . : .. : . :: . . : : : * *. . :* :.. :. .:: . *. . . .. . : :* : : . . : : : . . . ..: .: : .: . . : : : : :: . :. :: : : .: : . : : .. : ::: * .. . : * . * .. *. . : : . :. * : :. :::.:: ", "identical_positions": 17, "similar_positions": 229, "identity": "1.5%" }, { "cls_id": "homologset.agr.HGNC:16688", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B0BMV4-1", "uniprot_id": "B0BMV4_RAT", "id": "B0BMV4-1", "name": "Protein YIF1", "aln": "MAYHSGYGVHGSKHR----TRAAPNP--PPLFDDT----------SGG------------YSSQLGGYPAPGADVAFNVNNLLGDP-------------------------------------------------------VANMAMAYGSSIASQGKDIVHKELHRFVSINKLKYFFAVDTAYVAKKLGLLVFPYTH--QNWKVQYSHDVPLPPRKDLNAPDLYIPTMAFITYVLLAGMALGIQQRFSPEVLGLCASTALVWVLMEVLALLLGLYLATVR--SELGTFHLLAYSGYKYVGMILSVLTG-LLFGSDGYYVALAWTSSALMYFTVRSLRT------------AASGPDSMG-----GPTPRQHLQLYLTLGAAAFQPLIIYWLTFHLVR------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91XB7-1", "uniprot_id": "YIF1A_MOUSE", "id": "Q91XB7-1", "name": "Protein YIF1A", "aln": "MAYHSAYGVHGSKHR----TRAAPDP--PPLFDDT----------SGG------------YSSQLGGYPAPGADVAFSVNNLLGDP-------------------------------------------------------VANMAMAYGTSIASQGKDIVHKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTH--QNWKMQYSHDVPLPPRKDLNAPDLYIPTMAFITYVLLAGMALGIQQRFSPEVLGLCASTALVWVFMEVLALLLGLYLATVR--SELSTFHLLAYSGYKYVGMILSVLTG-LLFGSDGYYVALAWTSSALMYFIVRSLRT------------AASGPDSMG-----GPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95070-1", "uniprot_id": "YIF1A_HUMAN", "id": "O95070-1", "name": "Protein YIF1A", "aln": "MAYHSGYGAHGSKHR----ARAAPDP--PPLFDDT----------SGG------------YSSQPGGYPATGADVAFSVNHLLGDP-------------------------------------------------------MANVAMAYGSSIASHGKDMVHKELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTH--QNWEVQYSRDAPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVR--SDLSTFHLLAYSGYKYVGMILSVLTG-LLFGSDGYYVALAWTSSALMYFIVRSLRT------------AALGPDSMG-----GPVPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PC24-1", "uniprot_id": "YIF1A_DANRE", "id": "Q6PC24-1", "name": "Protein YIF1A", "aln": "MNFQQ-QGYRATKPR----ARASPPTGGPMLFDDT----------SSGPPPMNNQN---YYSSGYNMAEMPAGGQEPGVGNIFADP-------------------------------------------------------MANAAMMYGSTLANQGKDIVNKEINRFMSVNKLKYFFAVDTKYVMKKLLLLMFPYTH--QDWEVRYHRDTPLTPRHDVNAPDLYIPTMAFITYILLAGMALGIQKRFSPEVLGLCASTALVWMIIEVLVMLLSLYLLTVH--TDLSTFDLVAYSGYKYVGMILTVFCG-LLFGSDGYYVALAWSSCALMFFIVRSLKMKIL---------SSISADSMGA----GASAKPRFRLYITVASAAFQPFIIYWLTAHLVR------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IMR4-1", "uniprot_id": "Q8IMR4_DROME", "id": "Q8IMR4-1", "name": "", "aln": "MNYNPNPGMRNRKWEN---SSAAGRPRPPKRVSDVNAMGPSAPMMGGGATFMAPPTGPGILDPNMYGAPAPAPVNSYGFDPNLGQPSQHIQQPPQQQPGYGYGAPPPQQAAGPPTYGIGAPQPVAPPTGQYPQFAMFQQPIVQDMAMQYGQKLADQGKQIMENQFEKWVPVAKLKYYFAVDNAYVGRKLRLLFFPYMH--KDWSLRYDQEHPVQPRYDVNAPDLYLPTMGYITYVIVAGLLLGMQKRFSPEQLGIQASSAMAYSIFELVIYSLALYVMNVK--TSLKTLDLLAFTGYKYVNIVVCLMVS-TLFFKSGYYIALAYTSFSFGFFMLRTLRTKLLQDNSPAAPSGAINYDPYGNPQQFDYSGGKKRKLYFLFMIVAGQALFAFLLSKHLYLPEAEVLTVPKTF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53845-1", "uniprot_id": "YIF1_YEAST", "id": "P53845-1", "name": "Protein transport protein YIF1", "aln": "MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRN------TPVNGQGNANMN-------ANVNGSGGGFPFQDPRGSMAFQLGQS---------------------------------------------------------AFSNFIGQDNFNQFQETVNKATANAAGSQQISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMGLVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFN---------LLSRSGAEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG-----------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :: : : * . . * . . .. :.:. : * .: :: :.: . ::. :* *.. ** .** *:..*: : ::*. : ** *:*:**:*:* *. :**::: . *:: *.** * *:::.: :::: *.**: ..: ..*:.: ***:* ::: : : . : : :: * :*::: . . : . . : . :: . * .: : : ", "identical_positions": 41, "similar_positions": 100, "identity": "10.0%" }, { "cls_id": "homologset.agr.HGNC:16691", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GK03-1", "uniprot_id": "A0A8I6GK03_RAT", "id": "A0A8I6GK03-1", "name": "Gamma-tubulin complex component", "aln": "MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLADPHLSISHVNYSLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQMEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFEN-QNVNLTRKGS----------------ILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDGIRSTVAEHLWKLMVEESDLLGQLKIIKDFYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEYHGKDHKADATQPREVPSRETSPREPPSSGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQR-KHLKSNQTDAVKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLK--------------PVFHCLNEILDLCHSFCSLVSQNLGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGTLGSFGM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D4F8-1", "uniprot_id": "GCP4_MOUSE", "id": "Q9D4F8-1", "name": "Gamma-tubulin complex component 4", "aln": "MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPPQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLADPHLSISHVNYSLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGTLSAQLEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFEN-QNVNLTRKGS----------------ILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDFYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEYHGKDHKADATQPREVPSRETSPREAPSSGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQR-KHLKSNQTDAVKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLK--------------PVFHCLNEILDLCHSFCSLVSQNLGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGTLGSFGM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UGJ1-1", "uniprot_id": "GCP4_HUMAN", "id": "Q9UGJ1-1", "name": "Gamma-tubulin complex component 4", "aln": "MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSISHVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFEN-QNVNLTRKGS----------------ILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDFYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEYHGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQR-KHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLK--------------PVFHCLNEILDLCHSFCSLVSQNLGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGTLGSFGM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VKU7-1", "uniprot_id": "GCP4_DROME", "id": "Q9VKU7-1", "name": "Gamma-tubulin complex component 4 homolog", "aln": "MIHDLLLACRSHNPEQLGIKAFN--ETTVIDQFIHPCEREIFMDIIKIIKVYQEVEQFTHSSGRKSDTHGELP-----DSLHGYYLLNLAKGIEMALEEYYAEIGRLEKYCLGNERNSLSYVYNALYAKFPLLVFMRNLITEIHVLNLRGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAFFSSLAHWLLFGVIDDVHSEFFIKFTPT-----------------DAVDGSSFSKSATCSLLSAEKNPEDYIWQYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFKMGRNVKVKNKTDPLAAKLAELDSDDIYQLWSGRESEFFKMVVDLSNEDTINVFRLEKVIIDIKNYVSARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYLEFCSQMVGTMETYREERFKN-VTRSFELAATVTGITDD----LDKFSLICQRSTSEPDDTSDFNFLQG--------------LSLKYEYEWPLNLLFSPTTIERYNNIFRFLLIIRTYQYEIQRVWAKQTWRAKSAKDVPPNNKIITLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIKSRSDFEVIQRAHTVFLANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHMTQTKD--PSDDLEDEVDQLNESFGVQIASLIQLLVDVKSASCLGPLSQLLLRLDFNCWFSASHNTSA----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:**** .: . : : . :.: *:**.* .:: : :: . * .. :* .. : : :.. * ..*** ** :..*:: .*: * : **: *.: : *:*:* * *: : :: :*: :::** :*..::::. * :..*:: *: :..::..*: *:*.*:: * *.***** *: ..: *..: : *:. *: : *:.:.:. **.::.: :***:****::* :*: :**::..* . : ..:*. * : *.:: :.:. :*:*: *:. *: :* :: *:* ** *: :****:******:: * . ::* :: *. :*: :* . : ** * :::: : . :.* *. : . *.*.*: :***::**:*:.:*:** :*::** :* * *:*: ** * * * *. .: ***:: *:::*:***:*********. *:: *:* *** *: ** **:*:*::.*:* : *:: * :::.:*..*. :.. : .: ::. * :.*. * : *:::* .*:. . . *:*******:* ::: : .* . ", "identical_positions": 177, "similar_positions": 244, "identity": "25.32%" }, { "cls_id": "homologset.agr.HGNC:16692", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5HZW5-1", "uniprot_id": "CD320_RAT", "id": "Q5HZW5-1", "name": "CD320 antigen", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARCGAGRAAALGL-------VLRLLLGLRTGPEAAPAPTSA-------PAHTLVQVSGPRAGSCPTDTFKCLTSGYCVPLSWRCDGDRD-----------------------------CSD-------GSDEEECR-----------------IEPCAQ---------------------------------------NRQCQPQPALP------CSCDNISGCSAGSDKNL-NCSRSPCQEGELRCILDDVCIPHTWRCDGHPDCPDSSDEL-SCDT---------------------------------------------------------------------------------------------------------------------------------------DTETDKIFQEENATTSMSSMIVEKETSFRNVTVASAGHPSRNPNAYGVIAAAG-----------------------VLSAILVSATILILLR--LRGQGY---------------------LPPTGLLVAVKESLLLSERKTSLI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z1P5-1", "uniprot_id": "CD320_MOUSE", "id": "Q9Z1P5-1", "name": "CD320 antigen", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARGGAGRAVALGL-------VLRLLFGLRTGLEAAPAP-----------AHTRVQVSGSRADSCPTDTFQCLTSGYCVPLSWRCDGDQD-----------------------------CSD-------GSDEEDCR-----------------IESCAQ---------------------------------------NGQCQPQSALP------CSCDNISGCSDVSDKNL-NCSRPPCQESELHCILDDVCIPHTWRCDGHPDCLDSSDEL-SCDT---------------------------------------------------------------------------------------------------------------------------------------DTEIDKIFQEENATTTRISTTMENETSFRNVTFTSAGDSSRNPSAYGVIAAAG-----------------------VLSAILVSATLLILLR--LRGQGY---------------------LPPPGLLVAVKESLLLSERKTSLI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NPF0-1", "uniprot_id": "CD320_HUMAN", "id": "Q9NPF0-1", "name": "CD320 antigen", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSG--GWMAQVGAWRTGALGL-------ALLLLLGLGLGLEAAASPLS---------TPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLD-----------------------------CSD-------GSDEEECR-----------------IEPCTQ---------------------------------------KGQCPPPPGLP------CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL-GCGTN-------------------------------------------------------------------------------------------------------------------------EILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAA-----------------------VLSASLVTATLLLLSW--LRAQER---------------------LRPLGLLVAMKESLLLSEQKTSLP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VLZ6-1", "uniprot_id": "Q9VLZ6_DROME", "id": "Q9VLZ6-1", "name": "FZ domain-containing protein", "aln": "MAEQKQLEAIANETSSVTGLRRQPTKYPHGLNITVQTIDDDNEGSPKDHSDYTRASGDSCWSKTQKYHIGMLGSPETLAELQVRRYKYPLTANYYLNSKLERPEKPTPWMLLGYARSVCRWKYLRWPIIFVASVLLFFGLITYCLWLHDVSVARAKFLQRRYEATLTSTSSSSNEVWDEETTSSTERSPQETTRLEDMDDSDESTELPEIAFGDDGDPEAGGEDGDGDYDDTLLP--ADSIRFTSGHQNSFGVPIEQDKRMLQLLKELLHKPQATPAGNEPTLTRVSPTLPPPLSASGRPTEAMALTTPSTTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRDAVSMAAYDSL-IRANCSVRAAEFICGALEPECRPLHIGQLPPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQN----WQCDKIKDCQGGEDEDE---QCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQ-DCDEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATTDEDAGTETKFQIHQVAAPAPPVNSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYR--ERPSRRRLTSTTAPPTTSSAPPETSTATTTTGPLSSTRRSLRTTPNRSRKPKS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IQA9-1", "uniprot_id": "Q8IQA9_DROME", "id": "Q8IQA9-1", "name": "", "aln": "-------------------MLAEALGYGYLLAYVICLLCWPGEAYPASSSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRS-SPLVFKNDAVAGDVWYQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRDYGIEHILTCEADNCQVR----LDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRLFDCIWIIKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQG------------------TTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSAGGELPTAGGSATTPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRSWLVVQQVPPGRGYRVRRLRHTFSSPEAFTSDELHLPYPDFLSYGTNLPHERSSSNFGSELSRDPSSYSVGKRARLTPEDTSGSETITQEMEQSNQTLQSHVIVESHPNHSESESEAEQQVSCFGAVAQRPKRRHRGHVRSRSFSNARGGSAGRRRLMQRSSSADLLMNYATMAVSTPQKTSEAMQRLFFI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . : : * : : . .:. : . * : .. . .: : . : . : : . * : . . . * .. .: *: :** .* *.*** .* . : * . .: . . : .. .:: . : . * : .* : .. ", "identical_positions": 16, "similar_positions": 60, "identity": "1.59%" }, { "cls_id": "homologset.agr.HGNC:16693", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3UN16-1", "uniprot_id": "GP162_MOUSE", "id": "Q3UN16-1", "name": "Probable G protein-coupled receptor 162", "aln": "MARGGLGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRAGGSVGTKAGGLGGLGTRPAFEVPAIVVEDTRGKRRSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRTVWEQCVAIMSEDDGDDDGTCDDYTDGRVCKIRFDANGATGSGSRDPTQVKLLPGRHMLFPPLERVHYLQ------------VPLSRRLSHDETNIFSTPRAPGSFLHKWSSSDDIRILPAQSRALGGPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGPSPRRPRPLGFSPRRLSLGSPDSRAVGLPLGLSAGRRCSLTGSEGSSRAWGRPWGPGNPIFPQLTL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4AAS1-1", "uniprot_id": "D4AAS1_RAT", "id": "D4AAS1-1", "name": "", "aln": "MARGGLGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRAGGSVGAKAGGLGGLGTRPAFEVPAIVVEDTRGKRRSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRTVWEQCVAIMSEDDGDDDGACDDYTDGRVCKIRFDANGATGSGSRDPTQVKLLPGRHMLFPPLERVHYLQHLPPGLTCSSPQVPLSRRLSHDETNVFSTPRAPGSFLHKWSSSDDIRILPAQSRALGGPPEYPGQRLRIEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGPSPRRPRPLGFSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGSEGSSRAWGRPWGPGNPIFPQLTL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q16538-1", "uniprot_id": "GP162_HUMAN", "id": "Q16538-1", "name": "Probable G protein-coupled receptor 162", "aln": "MARGGAGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRVGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRTVWEQCVAIMSEEDGDDDGGCDDYAEGRVCKVRFDANGATGPGSRDPAQVKLLPGRHMLFPPLERVHYLQ------------VPLSRRLSHDETNIFSTPREPGSFLHKWSSSDDIRVLPAQSRALGGPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGHSPRRPRPLGLSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGGEESARAWGGSWGPGNPIFPQLTL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***** ********************************************************************************************************************************************************************************************************************.**. *:**** *.****************:**************************************************************************************************:****** ****::*****:*********.*****:********************** *************:***** ***************:************** *** *:************************************************************ *********:**********:********************.* *:**** .*************", "identical_positions": 559, "similar_positions": 19, "identity": "93.17%" }, { "cls_id": "homologset.agr.HGNC:16695", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZX74-1", "uniprot_id": "A0A8I5ZX74_RAT", "id": "A0A8I5ZX74-1", "name": "B-cell receptor-associated protein", "aln": "MSLQWTAVATFLYAEVFAVLLLCIPFISPKRWQKIFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFH-----MKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGTAEDGGKLDVGSPEMKLEE-NKILKTDLKKLKDELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVR-GPSDKKEE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61335-1", "uniprot_id": "BAP31_MOUSE", "id": "Q61335-1", "name": "B-cell receptor-associated protein 31", "aln": "MSLQWTTVATFLYAEVFAVLLLCIPFISPKRWQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTEKVNLQNNPGAMEHFH-----MKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDIGNTEMKLEE-NKSLKNDLRKLKDELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVR-GPSVKKEE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P51572-1", "uniprot_id": "BAP31_HUMAN", "id": "P51572-1", "name": "B-cell receptor-associated protein 31", "aln": "MSLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFH-----MKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAVDGGKLDVGNAEVKLEEENRSLKADLQKLKDELASTKQKLEKAENQVLAMRKQSEGLTKEYDRLLEEHAKLQAAVD-GPMDKKEE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W0M4-1", "uniprot_id": "Q9W0M4_DROME", "id": "Q9W0M4-1", "name": "Endoplasmic reticulum transmembrane protein", "aln": "MSLVWTLIAGFLYAEIALVLLLVLPVLTPYRWNRFFKSKFLSMLGQQAHIYFLLIMGILVIFLLEAIREMRKYSGLQQSNEVHLN-VEMQHS------MKLFRAQRNFYISGFAIFLALVIRRLVNLICTQANLMAQSEASFKQAQSATAAARSLLENK-----------------NTEKAKEAGEDTTLIELNKLRERVQELTSDLNREKKDKEAVKSQAESINREYDRLTEEYSKLQKKITIGGGGNKDD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07451-1", "uniprot_id": "YET3_YEAST", "id": "Q07451-1", "name": "Endoplasmic reticulum transmembrane protein 3", "aln": "MSLYYTLVFAILVVEIFMFSILALPIPSRYRRP-LTLLLLKPFKSSTVQVAIKCVLGFILLLFIDCINRVYSIDKELQLSSASQNNGAIIAQDRIEVLSRKFFAQRNMYLTGITLFLTFVVVRTFGLV---IELLTMKDIYRASPPVASSDVK------------------------------------KNDSVTAEAAAQSGASKDDHGDEKNFELLKKIQDIDDEIARLKEKSESLQEEIN---------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** :* : :* .*: . :* :*. : * . : : : : :: :::::.::.:..: . . : . * : : * ****:*::*::::*:::: * . *: *:: .: .. *: .: : . . . .. :: .:. : .: :.: * ** *: .** : ", "identical_positions": 28, "similar_positions": 78, "identity": "11.11%" }, { "cls_id": "homologset.agr.HGNC:16696", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CSN1-1", "uniprot_id": "SNW1_MOUSE", "id": "Q9CSN1-1", "name": "SNW domain-containing protein 1", "aln": "----------------------------------------------------------MALTSFLPAPTQLSQDQLEAEERARSQRSLQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRK---KKMSNALAIQVDPEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKEPMEP--PRFKINKKIPRGPPSPPAPVMHSP-SRKMTVKEQQEWKIPPCISNWKNAKGYTIPIDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKE-------DGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSN-EVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRKQRG--REGPVQFE--EDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A8G7-1", "uniprot_id": "D4A8G7_RAT", "id": "D4A8G7-1", "name": "SNW domain-containing protein 1", "aln": "MVPVPTRQAATIPTKRTTRPRVPFGQSACAVSIFHSVPRSRARIAPRRCGLRRKKRKKMALTSFLPAPTQLSQDQLEAEERARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRK---KKMSNALAIQVDPEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEP--PRFKINKKIPRGPPSPPAPVMHSP-SRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKE-------DGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSN-EVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLETRIKTNRFVPDKEFSGSDGRKRG--REGPVQFE--EDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q13573-1", "uniprot_id": "SNW1_HUMAN", "id": "Q13573-1", "name": "SNW domain-containing protein 1", "aln": "----------------------------------------------------------MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRK---KKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEP--PRFKINKKIPRGPPSPPAPVMHSP-SRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKE-------DGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSN-EVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRG--REGPVQFE--EDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P39736-1", "uniprot_id": "BX42_DROME", "id": "P39736-1", "name": "Puff-specific protein Bx42", "aln": "----------------------------------------------------------MSLSSLLPTPTNAIWDREDERRLVARGAPKIGALVSAKIAAPPYGQRKDWVPHTDADFGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQLLPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQGDTFNSGAKQRVIRMVEAQLDPMEP--PKFRINKKIPRGPPSPPAPVLHSP-SRKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQKEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRAAPEKRSKLQKERERDISEQIALGLPAKSAGNGETLFDQRLFNTTKGMDSGYG--DDEAYNVYDKPWRDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTKRFVPDKQFSGASKEAAAGQRSGPVEFEKEEDPFGLDQFLNMAKKAP--KRAEEKNNERSSHSDRKRSKRD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P28004-1", "uniprot_id": "PRP45_YEAST", "id": "P28004-1", "name": "Pre-mRNA-processing protein 45", "aln": "-----------------------------------------------------------MFSNRLPPPKHS-------------QGRVSTALSSDRVEP--------------------------------------------------------AILTDQIAKN---------VKLDDFIPKRQSNFELS-VPLPTKAEIQECTARTKSYIQRLVNAKLANSN------NRASSRYVTETHQAPANLLLN--NSHHIEVVSKQMDPLLPRFVGKKARKVVAPTENDEVVPVLHMDGSNDRGEADPNEWKIPAAVSNWKNPNGYTVALERRVGK-ALDNENNTINDGFMKLSEALENADKKARQEIRSKMELKRLAMEQEMLAKESKLKELSQRARYHNGTPQTGAIVK----------------------------PKKQTSTVARLKELAYSQGRDVSEKIILGAAKRSEQP-DLQYDSRFFTR--GANASAKRHEDQVYDN-----------------------PLFVQQDIESIYKTNYEKLDEAVNVKSEGASG--SHGPIQFT----------------------KAESDDKSDNYGA--------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. **.*.: :* * : . : * **:: . :::* . : : * : : * * .*: ::: .. *:: : : ..::*: * . . : . :.: *.:*. * :*: * : .* :. . .**:* *.. : :*****..:*****.:***:.:::*:. . . : **: * *::*** **:***: :. : :::: ::* :*. *: ::*:** ... :. : : . :: : .:* .. **:** * ** . : :*.*:*. * ::. :*: *: *::: :*: *: .. . . **::* :...... . ", "identical_positions": 78, "similar_positions": 143, "identity": "12.75%" }, { "cls_id": "homologset.agr.HGNC:16697", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P40890-1", "uniprot_id": "VTH2_YEAST", "id": "P40890-1", "name": "VPS10 homolog 2", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSG------------------LMYVGREIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTG-TSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICD-KSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFN---SSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVR-LGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTSRTDLLG----ASNIPDALPARS--ASHESDLAAARSEDK------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P40438-1", "uniprot_id": "VTH1_YEAST", "id": "P40438-1", "name": "VPS10 homolog 1", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSG------------------LMYVGREIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTG-TSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICD-KSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFN---SSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVR-LGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTLRTDLLG----ASNIPDALPARS--ASHESDLAAARSEDK------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53751-1", "uniprot_id": "YN94_YEAST", "id": "P53751-1", "name": "Uncharacterized membrane glycoprotein YNR065C", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMTGSVGDGSEFDWEDQKTFISRDGGLTWRFVHNSSGLYATGDLGNIIVYIP--YDPEEDGDFQSEFYYSLDQGRTWNEYELTNAISSVHPYKLINPTPDGSGSKFIFKG-TFATTDSETNSITSLKGVEYIIDFSAAFDSRTCEEEDFEDWDLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCGESDYECSFEFVRDANGLCIPDYNLIAFSNICD-KSKDKSVLVEPLQLIKGDECKTPMKIEPVDIPCDEIPEEGSSDREIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTNGEKIVEVVFNPYFN---SSAYLFGSKGNIFSTHDRGHSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFEYPSNEEMVMCQVKKKSSETRSLVSSIDFFQGDNKIIFENIIGYLSTGGYIIVAVPHEDNELRAYVTIDGTEFAEAKFPYGQDVSKQEAFTILGSEKGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDKLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGKKRADFKYSPLGSRTGCLFGHQTEFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVR-LGLCISLITKSAFQRTKAGVARFSSKLRARFGNRKGPTYSSLLQGQFSDESD----GLHEDANDLSSFTSQDSNFEIEQEDAYRPEQEHTSQIDQPA----TSNIPDALPARS--AIHKPDSTAVRNEDE------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P32319-1", "uniprot_id": "VPS10_YEAST", "id": "P32319-1", "name": "Vacuolar protein sorting/targeting protein VPS10", "aln": "MILLHFVYSLWALLLIPLTNAEEFTPKVTKTIAQDSFDILSFDDSNTLIRKQDTSVTISFDDGETWEKVEGIEGEITWIYIDPFNRHDRAVATAMNGSYLYITNDQGKSWERITLPDSGESISPRECYIETHPLNKNYFLAKCNYCEKTEVNNDNEENSGDEEGQFEIFNITRCTDKVFASNDGGKSFSEIKSSLERNENSPISISDCGFAKTSKDSDLESSDTSIICLFQNMQLIMDEFSSPYTESKLVLTTDWGKSLKEFDQFKDKVVNGYRILKSHMVVLTQGDRYNDMSSMDVWVSNDLSNFKMAYMPTQLRHSMQGEIYEDAMGRIILPMSRERSDQEEDKGIVSEILISDSQGLKFSPIPWTANEVFGYINFYQPTYLKGTMIASLYPLSRRRNRKGKAKGVKSKGVTKISVDNGLTWTMLKVVDPDNADSFDCDITDFENCSLQNMFYTREGSTPTAGILMTTGIVGDGSVFDWGDQRTFISRDGGLTWKLAFDFPCLYAVGDYGNVIVAIP--YNADEDDDPQSEFYYSLDQGKTWTEYQL---ETTIYPNEVMNTTPDGSGAKFILNGFTLAHMDGTTN-------FIYAIDFSTAFNDKTCEENDFEDWNLAEGKCVNGVKYKIRRRKQDAQCLVKKVFEDLQ--LFETACDKCTEADYECAFEFVRDATGKCVPDYNLIVLSDVCD-KTKKKTVPVKPLQLVKGDKCKKPMTVKSVDISCEGVPKKGTNDKEIVVTENKFDFKIQFYQYFDTVTDESLLMINSRGEAYISHDGGQTIKRFDSNGETIIEVVFNPYYN---SSAYLFGSKGSIFSTHDRGYSFMTAKLPEARQLGMPLDFNAKAQDTFIYYGGKNCESILSPECHAVAYLTNDGGETFTEMLDNAIHCEFAGSLFKYPSNEDMVMCQVKEKSSQTRSLVSSTDFFQDDKNTVFENIIGYLSTGGYIIVAVPHENNELRAYVTIDGTEFAEAKFPYDEDVGKQEAFTILESEKGSIFLHLATNLVPGRDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKIQGLEGIILTNIVSNSDKVAENKEDKQLKTKITFNEGSDWNFLKPPKRDSEGKKFSCSSKSLDECSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGPNLLPYKECSTFFTTDGGETWAEVKKTPHQWEYGDHGGILVLVPENSETDSISYSTDFGKTWKDYKFCADKVLVKDITTVPRDSALRFLLFGEAADIGGSSFRTYTIDFRNIFERQCDFDITGKESADYKYSPLGSKSNCLFGHQTEFLRKTDENCFIGNIPLSEFSRNIKNCSCTRQDFECDYNFYKANDGTCKLVKGLSPANAADVCKKEPDLIEYFESSGYRKIPLSTCEGGLKLDAPSSPHACPGKEKEFKEKYSVSAGPFAFIFISILLIIFFAAWFVYDRGIRRNGGFARFGEIRLGDDGLIENNNTDRVVNNIVK-SGFYVFSNIGSLLQHTKTNIAHAISKIRGRFGNRTGPSYSSLIHDQFLDEADDLLAGHDEDANDLSSFMDQGSNFEIEEDDVPTLEEEHTSYTDQPT----TTDVPDTLPEGNEENIDRPDSTAPSNENQ------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P25657-1", "uniprot_id": "YCY9_YEAST", "id": "P25657-1", "name": "Uncharacterized protein YCR099C", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRSIFLLHFDYKTCEEEDFEDWNLADGKCLNGAKYMYKRRKQDARCLVKRTFKDMI--LHEIPCDSCTESDYECSSEFVRDAKGDCIPDYDQIALSDICD-KANGETVSLEPLQLIKGDKCKKPMEIEAMNIPCEKILRESSNGKKIATIENKFDFEI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9JLC4-1", "uniprot_id": "SORC1_MOUSE", "id": "Q9JLC4-1", "name": "VPS10 domain-containing receptor SorCS1", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGK-VGAGDGSSAGLSALLAGAGLLMLLAPGVCSSLSCCPPQHPSSTPRRTLTPRGFPHPGPLGRAPA----------------------TPPPLFMRPLFAVAP-GDRALFLERAGGSRVSVATAARSGR-----RRRSGTEPEKIE-----------PGEGASRSRRDMLKDGGQ-----QGLGTG-----------------ARDPGKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK---CKIMLLTDPEIESSLLISSDEGATYQKYRLNFYLQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQESVVPNRFYWSVMGSSKEPDLVHLEARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYVSYRRSPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYN--LYISDTRGVYFTLALENVRSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDA-------DLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELS--------DSDISMFVSSDAGNTWR------QIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFG-HFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQG--------EACIMGAKRIYKKRKSERKCMQ--KYAGAMESEPCVCTEADFDCDYGYERHSNGQ-------CLPAFWFNPSSLSKDCSLGQSYLNSAGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGI-AVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPS---------------------QVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGN---AILQDTKTIAVYEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPTAAELFVLP-YQDGTRENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVA----------------LPSPPSPS-AQPGDSSLRLQRPR------------PATPPSSPKRGS---AGAQFAI------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AEA1-1", "uniprot_id": "A0A8I6AEA1_RAT", "id": "A0A8I6AEA1-1", "name": "VPS10 domain-containing receptor SorCS1", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGK-VGAGDGSSAALSALLTGAGLLMLLAPGICSSLSCCPPQHPSSTPRWTLTPRGFSYPGPLGRAPA----------------------TPPPLFMRPLFAVAP-GDRALFLERAGGSRVSVATASRSGR-----RRRSGMDPEKTE-----------PGEGTSRSRRDMLRDGGQ-----QGPGTG-----------------ARDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK---RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEAVVPNRFYWSVLGSNKEPDLVHLEARTVDGHSIYLTCRMQNCTEANRNKPFPGYIDPDSLIVQDDYVFVQLTSGGRPHYYVSYRRNPFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYN--LYISDTRGVYFTLALENVQSSRGPEGNVMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDA-------DLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASRDTAPSIIVASGNIGSELS--------DSDISMFVSSDAGNTWR------QIFEEEHSILYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFG-HFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQG--------EACIMGAKRIYKKRKSERKCMQG-TYAGAMESEPCVCTEADFDCDYGYERHSSGQ-------CLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGI-AVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPS---------------------QVGTLTYVWWYGNNTEPLITLEGSISFKFTSEGMNTITVQVSAGN---AILQDTKTIAVYEEFRSLRLAFSPNLDDYNPDIPEWRRDISRVIKKSLVEATGIPSQHILVAVLPGLPTAAELFVLP-YQDGARENKRSPEDLEQISEVLIHKLNQNLVHFELKPGVQVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKEQ-ELINPVSHTESRPTAPHPDLRRPGQLVDEKVESHLLDQDKPHHLHRQSGDLLGHNLQSKENPQRLQETC-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WY21-1", "uniprot_id": "SORC1_HUMAN", "id": "Q8WY21-1", "name": "VPS10 domain-containing receptor SorCS1", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGK-VGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGRAPA----------------------TPLPLVVRPLFSVAP-GDRALSLERARGTGASMAVAARSGR-----RRRSGADQEKAE-----------RGEGASRSPRGVLRDGGQ-----QEPGTR-----------------ERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK---RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYN--LYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDT-------DLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELS--------DTDISMFVSSDAGNTWR------QIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFG-HFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQG--------EACIMGAKRIYKKRKSERKCMQG-KYAGAMESEPCVCTEADFDCDYGYERHSNGQ-------CLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGI-AVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPS---------------------QVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGN---AILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLP-YQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVA----------------LPSPPSPS-TQPGDSSLRLQRAR------------HATPPSTPKRGS---AGAQYAI------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PN08-1", "uniprot_id": "A0A8M9PN08_DANRE", "id": "A0A8M9PN08-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERGIRYCRVHVRAFCTLLLILFAWVPVAETVITCRSCHLLDKWSGRELLVKMDSGVDS-GKVGDQDG----------------------DGSLFNLAGAETGQPDCGASDSGEHAHSVRKRNTESLRSGKTPPDEKWKSMRSHDKVYNLKLAASRATAPGDPHHRVRRGTQEPGSPPGARFQPLGFGNVTARAARRVPRSELRWNRDERRTAASRQEELKLTSSTFALTGDSAHNQAMVHWSGQNSSVILMLTKLYDFNLGSVTESSLWRSTDYGTTYEKLNEKVGVKTILSYLYVSPNNK---RKIMLLTDPEVESSLLISSDEGATYQKYRLNFYILSLLFHPEQEDWILAYSHEQKLYSSVEFGRRWQLVHERVAPNRFYWSKTGLDKEPGLIHLETSISESQALYVTCKLQNCTDANKGKPFPGYIDPNSLVVQDEYVFVQVSTGGRPIYYVSSRRDVFTPMKLPKYTLPKDLHVISTDENRVVAAVQEWNQNDTYN--LYVSESGGIYYTLALENVMSSMGPEGNVMIDLYEVAGIKGMFLANKKLNNEVKTYITYNKGRDWRLLQAPSA-------DLRGNRIHCMLPYCSLHLHLHVSANPYTSGNIASRESAPGIILASGSIGAELT--------SSNVSMFITSDAGNTWR------QIFDEEYSVLYLDQGGALVAIRHTPLPIRHLWLSFDEGRVWNKYSFTSSPLFVDGVLGEPGEETLIMTIFG-HVSHRSEWQLVKIDFRSIFNRRCVESDYVPWDLHDQG--------ERCLMGVKRVYRKLKATARCVMGKTYSVTMISEPCHCTESDFECDYGFERRTDGK-------CTPAFWFPPSSMSRTCTTEHTFLNSTGYRKVVSNNCTGGVIERYTARRQLCPSQAPRGLHLVTSEGKLTATLASNVTFLVFLEEGDGSKTSITVDFGDGN-AFTYSNVSSIEDGIKHIYKTVGIYRVSATAENSLGSETVLLFLHVTCQLDSIHLSAPFVAVKNKEVNLTVVLYPS---------------------QVGTVTYIWWFGNNSEPVITLDGSVSFTFSREGISIVTVQVSAGN---NILQDRKTIAVHEYFRSHLLAFSSNLDDHNPDVAEWRLDVSRVIKTSMMQATGVSPDLLLVTVLPGLPTAAEFFLLPDKQLTEGKPDKTATHLDQLSEVVLSALNQNLVQFTLRPGVQITVYAAHLSAAPLVDTSENHSGSAMLMLLSVVVLGLAIFLIYKFKRKIPGLHVYAAMQDEKEQEMIQSPVSPTDSTPSSSSQRELLTS------------LEPLDTEPNTQTIECIKPHPRVKFSSDLPTYIDV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :: *: : * ...:: : : . :: : . * : :: * :.. * .: :*: .*.. : . :. : . . :: . ", "identical_positions": 8, "similar_positions": 39, "identity": "0.5%" }, { "cls_id": "homologset.agr.HGNC:16698", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P40890-1", "uniprot_id": "VTH2_YEAST", "id": "P40890-1", "name": "VPS10 homolog 2", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSG------------------LMYVGREIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLT---WTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTG-TSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDK-SKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSS------DKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHP--CPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLG--------LCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTSRTDLLGASNIPDALPARS--ASHESDLAAARSEDK-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P40438-1", "uniprot_id": "VTH1_YEAST", "id": "P40438-1", "name": "VPS10 homolog 1", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSG------------------LMYVGREIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLT---WTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTG-TSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDK-SKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSS------DKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHP--CPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLG--------LCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTLRTDLLGASNIPDALPARS--ASHESDLAAARSEDK-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53751-1", "uniprot_id": "YN94_YEAST", "id": "P53751-1", "name": "Uncharacterized membrane glycoprotein YNR065C", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMTGSVGDGSEFDWEDQKTFISRDGGLTWRFVHNSSGLYATGDLGNIIVYIP--YDPEEDGDFQSEFYYSLDQGRTWNEYELTNAISSVHPYKLINPTPDGSGSKFIFKG-TFATTDSETNSITSLKGVEYIIDFSAAFDSRTCEEEDFEDWDLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLS--LDETPCNSCGESDYECSFEFVRDANGLCIPDYNLIAFSNICDK-SKDKSVLVEPLQLIKGDECKTPMKIEPVDIPCDEIPEEGSS------DREIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTNGEKIVEVVFNPYFNSSAYLFGSKGNIFSTHDRGHSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFEYPSNEEMVMCQVKKKSSETRSLVSSIDFFQGDNKIIFENIIGYLSTGGYIIVAVPHEDNELRAYVTIDGTEFAEAKFPYGQDVSKQEAFTILGSEKGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDKLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGKKRADFKYSPLGSRTGCLFGHQTEFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHP--CPGKEKAFREKYSINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLG--------LCISLITKSAFQRTKAGVARFSSKLRARFGNRKGPTYSSLLQGQFSDESD----GLHEDANDLSSFTSQDSNFEIEQEDAYRPEQEHTSQIDQPATSNIPDALPARS--AIHKPDSTAVRNEDE-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P32319-1", "uniprot_id": "VPS10_YEAST", "id": "P32319-1", "name": "Vacuolar protein sorting/targeting protein VPS10", "aln": "MILLHFVYSLWALLLIPLTNAEEFTPKVTKTIAQDSFDILSFDDSNTLIRKQDTSVTISFDDGETWEKVEGIEGEITWIYIDPFNRHDRAVATAMNGSYLYITNDQGKSWERITLPDSGESISPRECYIETHPLNKNYFLAKCNYCEKTEVNNDNEENSGDEEGQFEIFNITRCTDKVFASNDGGKSFSEIKSSLERNENSPISISDCGFAKTSKDSDLESSDTSIICLFQNMQLIMDEFSSPYTESKLVLTTDWGKSLKEFDQFKDKVVNGYRILKSHMVVLTQGDRYNDMSSMDVWVSNDLSNFKMAYMPTQLRHSMQGEIYEDAMGRIILPMSRERSDQEEDKGIVSEILISDSQGLKFSPIPWTANEVFGYINFYQPTYLKGTMIASLYPLSRRRNRKGKAKGVKSKGVTKISVDNGLT---WTMLKVVDPDNADSFDCDITDFENCSLQNMFYTREGSTPTAGILMTTGIVGDGSVFDWGDQRTFISRDGGLTWKLAFDFPCLYAVGDYGNVIVAIP--YNADEDDDPQSEFYYSLDQGKTWTEYQL---ETTIYPNEVMNTTPDGSGAKFILNGFTLAHMDGTTN-------FIYAIDFSTAFNDKTCEENDFEDWNLAEGKCVNGVKYKIRRRKQDAQCLVKKVFEDLQ--LFETACDKCTEADYECAFEFVRDATGKCVPDYNLIVLSDVCDK-TKKKTVPVKPLQLVKGDKCKKPMTVKSVDISCEGVPKKGTN------DKEIVVTENKFDFKIQFYQYFDTVTDESLLMINSRGEAYISHDGGQTIKRFDSNGETIIEVVFNPYYNSSAYLFGSKGSIFSTHDRGYSFMTAKLPEARQLGMPLDFNAKAQDTFIYYGGKNCESILSPECHAVAYLTNDGGETFTEMLDNAIHCEFAGSLFKYPSNEDMVMCQVKEKSSQTRSLVSSTDFFQDDKNTVFENIIGYLSTGGYIIVAVPHENNELRAYVTIDGTEFAEAKFPYDEDVGKQEAFTILESEKGSIFLHLATNLVPGRDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKIQGLEGIILTNIVSNSDKVAENKEDKQLKTKITFNEGSDWNFLKPPKRDSEGKKFSCSSKSLDECSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGPNLLPYKECSTFFTTDGGETWAEVKKTPHQWEYGDHGGILVLVPENSETDSISYSTDFGKTWKDYKFCADKVLVKDITTVPRDSALRFLLFGEAADIGGSSFRTYTIDFRNIFERQCDFDITGKESADYKYSPLGSKSNCLFGHQTEFLRKTDENCFIGNIPLSEFSRNIKNCSCTRQDFECDYNFYKANDGTCKLVKGLSPANAADVCKKEPDLIEYFESSGYRKIPLSTCEGGLKLDAPSSPHA--CPGKEKEFKEKYSVSAGPFAFIFISILLIIFFAAWFVYDRGIRRNGGFARFGEIRLGDDGLIENNNTDRVVNNIVKSG--------FYVFSNIGSLLQHTKTNIAHAISKIRGRFGNRTGPSYSSLIHDQFLDEADDLLAGHDEDANDLSSFMDQGSNFEIEEDDVPTLEEEHTSYTDQPTTTDVPDTLPEGNEENIDRPDSTAPSNENQ-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P25657-1", "uniprot_id": "YCY9_YEAST", "id": "P25657-1", "name": "Uncharacterized protein YCR099C", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRSIFLLHFDYKTCEEEDFEDWNLADGKCLNGAKYMYKRRKQDARCLVKRTFKDMI--LHEIPCDSCTESDYECSSEFVRDAKGDCIPDYDQIALSDICDK-ANGETVSLEPLQLIKGDKCKKPMEIEAMNIPCEKILRESSN------GKKIATIENKFDFEI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "D3ZW09-1", "uniprot_id": "D3ZW09_RAT", "id": "D3ZW09-1", "name": "VPS10 domain-containing receptor SorCS2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHRGTPSAPKRPGLTAPDRSSQVLLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRWGPSVQVTRLL---PAGRTESSNRQDPQTRESEPGVPGLRPGSASGPSTDGAPALGKGRRVRAAPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRK-IILVSSSLGDREQSLFLSTDEGTTFQKYPVPFLVETLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQEQVTKDHVFWAVSGVDDDPNLVHMEARDLSGGYRYYTCLIHNCSAQPHTAPFPGPTDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKLFCPQDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQP-------------------PDCHLHLHLRWADNPYVSGTVH--TKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKTLKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFR----------PSFPRPCVEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTVNKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGINQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLQFSRDLDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPPPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRVLVELRDTDAGPQR-----------------------PGGSGGYWAVVVLFVIGLFAVGAFILYKFKRK-------------------------RPGRTVYAQMHNEKEQEMTSPVSHSEDAQSAMQG--------------NHSGVVLSINSREMHSYLVG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EPR5-1", "uniprot_id": "SORC2_MOUSE", "id": "Q9EPR5-1", "name": "VPS10 domain-containing receptor SorCS2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHRGPPSAPKRPGPTAPDRSFQALLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRQGPGVQITRLL---PAGRTESGDRKDPQARESEPSVPGLGPGSASGPSTDGAPAPGKGRRARAVPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRK-IILVSSSLGDREQSLFLSTDEGATFQKYPVPFLVEMLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQERVTKDHVFWAVSGVDDDPNLVHVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALP-----KDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQP-------------------PDCYLHLHLRWADNPYVSGTVH--TKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFR----------PSFPRQCGEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTANKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGVNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTKFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLRFSRELDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPLPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRILVELRDTDTGPQR-----------------------PGGSGGYWAVVVLFVIGLFAVGAFILYKFKRK-------------------------RPGRTVYAQMHNEKEQEMTSPVSHSEDAQSTMQG--------------NHSGVVLSINSREMHSYLVG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96PQ0-1", "uniprot_id": "SORC2_HUMAN", "id": "Q96PQ0-1", "name": "VPS10 domain-containing receptor SorCS2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHRGPSRASKGPGPTARAPSPGAPPPPRSPRSRPLLLLLLLLG-ACGAAGRSPEPGRLGPHAQLTRVPRSPPAGRAEPGGGEDRQARGTEPGAPGPSPGPAPGPGEDGAPAAGYRRWERAAPLAGVAS--RAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRK-VILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALP-----KDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKP-------------------PDCHLHLHLRWADNPYVSGTVH--TKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFR----------PSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQ-----------------------LGGGGGYWAVVVLFVIGLFAAGAFILYKFKRK-------------------------RPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQG--------------NHSGVVLSINSREMHSYLVS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G5D7-1", "uniprot_id": "A0AC58G5D7_DANRE", "id": "A0AC58G5D7-1", "name": "VPS10 domain-containing receptor SorCS2", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTLIMAVFAHLYPAVFFACAWMALLGPISCHSSGIIKQRSERDR-------------------ELDSRGGHVTGTDEALISAYSRGDYSG--DPGGAAVGVPRVRRAS--------TPEKVSLLSSSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADSNKVLESSLWRSSDYGSTYTKLNLMPGTTIIVTNFYICPTNKKK-VILVSSSINERDQMLFISTDEGASFQRQPVSFTVDSLLFHPSEEDKLLAYSKEAKLYISTDLGHKWTLLQERVTKDRVFWAVTGVDVDPDLVHMEMQDISGGYLYVTCLIQNCSDKMVTAQFLGKIDHNSLSVQDEYIFVKVTTGNRTKYYVSYRRNEFVQMRFPKYSLP-----KDVQIVSTDENQVFLALQEWYQTDTYNLYQSDPQGVYYSIVLENVRSTKQPEENVLIDILEVRGVKGVFLANQKVDGKVMTLITYNKGRDWEALAPPATDMNGKPVSCKQ-------------------PDCHLHLHLRWADNPYVSGTVH--TKDSAPGLIMGAGNLGSQLVEYKEEMYITADCGKTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSIDEGRTWSIHNFTSTSVFVDGLLSEPGDETLVMTVFGHISYRSDWELVKVDFR----------QSFPRQCTEADYDSWKLTDLQGEKCIMGQERVYRRRKETSFCIKGKSYTSALTAKPCPCSEKDFTCDYGFERAPSLRLEGDRCYPDFWHNPDAPPENCHLGHSYKSSTGYRKVIANVCEGGLNKEQSAKQHSCPLLPPKGLQLGIKGQMLAVAPGDDITFIVHQEQGDTSSTRYQVDLMDGVRAIYENLTVTDEPIQHRYEKPGVYRVNVKAENSAGHDQAMLYIQVTAPLQDVHLEVVPIAGRNQDVNLTAIVLPTEANLTVFYWWIGDNMQPKLTLENSLITRFSEEGEVPVTVQASNGRSMVQDSKTVIVYDHFQIIPLSFSRNLDHFNPNIPEWRRDVGEVVTKIIAKLTGVPQEHLVTMLKPGLPTSADLYVLPQETTP-VKRSVFVDKRVPTIKQVLSENNVSFIVRGGLRVLVTLADLDSGPITSDVSVSTTETATQLTSSTQGSGLAAAGPGVWAVAVFLLISLISAAAFILFKFKRKNYKNHGWLLRPEESSLTRPWLRFRKLPGRNVYAQMHNEKEQEMTSPVNHSEDTQNIIQGEEFIDDDLDSQTLGNHSGVVLSINSRELHSYLTS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .* * :.* . . : : : .:.* : : * : * . : . *: : .: . :. * : . :: . . . . :* ::. * ", "identical_positions": 11, "similar_positions": 36, "identity": "0.68%" }, { "cls_id": "homologset.agr.HGNC:16699", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P40890-1", "uniprot_id": "VTH2_YEAST", "id": "P40890-1", "name": "VPS10 homolog 2", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRC---DLLTIKNSGLMYVG---------------REIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTGTSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDT------------------------SQQEHTSRTDLLGASNIPDALPARS--ASHESDLAAARSEDK", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P40438-1", "uniprot_id": "VTH1_YEAST", "id": "P40438-1", "name": "VPS10 homolog 1", "aln": "MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPIS-EKASNYFCDVTTHPIKKKHLIIRC---DLLTIKNSGLMYVG---------------REIYTTNDG-VSFSQVKPSFGKIDG-HISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTG-STIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIP--YRSNENGDVPSKFYYSLDQGKTWGEYDL---IMPIYPYRLVSTISDGSGSKFILTGTSITEDPIF--------ITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEIEQEDVDT------------------------SQQEHTLRTDLLGASNIPDALPARS--ASHESDLAAARSEDK", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53751-1", "uniprot_id": "YN94_YEAST", "id": "P53751-1", "name": "Uncharacterized membrane glycoprotein YNR065C", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMTGSVGDGSEFDWEDQKTFISRDGGLTWRFVHNSSGLYATGDLGNIIVYIP--YDPEEDGDFQSEFYYSLDQGRTWNEYELTNAISSVHPYKLINPTPDGSGSKFIFKGTFATTDSETNSITSLKGVEYIIDFSAAFDSRTCEEEDFEDWDLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCGESDYECSFEFVRDANGLCIPDYNLIAFSNICDKSKDKSVLVEPLQLIKGDECKTPMKIEPVDIPCDEIPEEGSSDREIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTNGEKIVEVVFNPYFNSSAYLFGSKGNIFSTHDRGHSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFEYPSNEEMVMCQVKKKSSETRSLVSSIDFFQGDNKIIFENIIGYLSTGGYIIVAVPHEDNELRAYVTIDGTEFAEAKFPYGQDVSKQEAFTILGSEKGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDKLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGKKRADFKYSPLGSRTGCLFGHQTEFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRTKAGVARFSSKLRARFGNRKGPTYSSLLQGQFSDESD----GLHEDANDLSSFTSQDSNFEIEQEDAYR------------------------PEQEHTSQIDQPATSNIPDALPARS--AIHKPDSTAVRNEDE", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P32319-1", "uniprot_id": "VPS10_YEAST", "id": "P32319-1", "name": "Vacuolar protein sorting/targeting protein VPS10", "aln": "MILLHFVYSLWALLLIPLTNAEEFTPKVTKTIAQDSFDILSFDDSNTLIRKQDTSVTISFDDGETWEKVEGIEGEITWIYIDPFNRHDRAVATAMNGSYLYITNDQGKSWERITLPDSGESISPRECYIETHPLNKNYFLAKCNYCEKTEVNNDNEENSGDEEGQFEIFNITRCTDKVFASNDGGKSFSEIKSSLERNENSPISISDCGFAKTSKDSDLESSDTSIICLFQNMQLIMDEFSSPYTESKLVLTTDWGKSLKEFDQFKDKVVNGYRILKSHMVVLTQGDRYNDMSSMDVWVSNDLSNFKMAYMPTQLRHSMQGEIYEDAMGRIILPMSRERSDQEEDKGIVSEILISDSQGLKFSPIPWTANEVFGYINFYQPTYLKGTMIASLYPLSRRRNRKGKAKGVKSKGVTKISVDNGLTWTMLKVVDPDNADSFDCDITDFENCSLQNMFYTREGSTPTAGILMTTGIVGDGSVFDWGDQRTFISRDGGLTWKLAFDFPCLYAVGDYGNVIVAIP--YNADEDDDPQSEFYYSLDQGKTWTEYQL---ETTIYPNEVMNTTPDGSGAKFILNGFTLAHMDGTTN------FIYAIDFSTAFNDKTCEENDFEDWNLAEGKCVNGVKYKIRRRKQDAQCLVKKVFEDLQLFETACDKCTEADYECAFEFVRDATGKCVPDYNLIVLSDVCDKTKKKTVPVKPLQLVKGDKCKKPMTVKSVDISCEGVPKKGTNDKEIVVTENKFDFKIQFYQYFDTVTDESLLMINSRGEAYISHDGGQTIKRFDSNGETIIEVVFNPYYNSSAYLFGSKGSIFSTHDRGYSFMTAKLPEARQLGMPLDFNAKAQDTFIYYGGKNCESILSPECHAVAYLTNDGGETFTEMLDNAIHCEFAGSLFKYPSNEDMVMCQVKEKSSQTRSLVSSTDFFQDDKNTVFENIIGYLSTGGYIIVAVPHENNELRAYVTIDGTEFAEAKFPYDEDVGKQEAFTILESEKGSIFLHLATNLVPGRDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKIQGLEGIILTNIVSNSDKVAENKEDKQLKTKITFNEGSDWNFLKPPKRDSEGKKFSCSSKSLDECSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGPNLLPYKECSTFFTTDGGETWAEVKKTPHQWEYGDHGGILVLVPENSETDSISYSTDFGKTWKDYKFCADKVLVKDITTVPRDSALRFLLFGEAADIGGSSFRTYTIDFRNIFERQCDFDITGKESADYKYSPLGSKSNCLFGHQTEFLRKTDENCFIGNIPLSEFSRNIKNCSCTRQDFECDYNFYKANDGTCKLVKGLSPANAADVCKKEPDLIEYFESSGYRKIPLSTCEGGLKLDAPSSPHACPGKEKEFKEKYSVSAGPFAFIFISILLIIFFAAWFVYDRGIRRNGGFARFGEIRLGDDGLIENNNTDRVVNNIVKSGFYVFSNIGSLLQHTKTNIAHAISKIRGRFGNRTGPSYSSLIHDQFLDEADDLLAGHDEDANDLSSFMDQGSNFEIEEDDVPT------------------------LEEEHTSYTDQPTTTDVPDTLPEGNEENIDRPDSTAPSNENQ", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P25657-1", "uniprot_id": "YCY9_YEAST", "id": "P25657-1", "name": "Uncharacterized protein YCR099C", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRSIFLLH----------------------------FDYKTCEEEDFEDWNLADGKCLNGAKYMYKRRKQDARCLVKRTFKDMILHEIPCDSCTESDYECSSEFVRDAKGDCIPDYDQIALSDICDKANGETVSLEPLQLIKGDKCKKPMEIEAMNIPCEKILRESSNGKKIATIENKFDFEI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q8VI51-1", "uniprot_id": "SORC3_MOUSE", "id": "Q8VI51-1", "name": "VPS10 domain-containing receptor SorCS3", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAAGTERP------AGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPGRLVSPASRPPVLPPLLPRAAENRWPEELASARRAAAPRRRSRLEPLSQASRG---EIRTEAAGMSPEGARWVPGIPS----PSQAGSARRTRRAQPPSPLERGDSWATALADGAKGSRPHTKGSREEVRATRTGGASTEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSVLISSDEGATYQKYRLT--------FYIQSLLFHPKQEDWVLAYS--------------------------LDQKLYSSMDFGRRWQLMHERITPNRFYWSVSGLDKEADLVHMEVRTADGYAHYLTCR---IQECAETTRSGPFARSIDISSLVVQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLP-KDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANK--------KVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHC-------------------LLPFCSLHLHLQLSENPYSSGRIS--SKDTAPGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGVETHIMTVFG-HFSLRSEWQLVKVDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRK----PGAQCALGREYSGSVVSEPCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQS-YLNSTGYRRIVSNNCTDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQG----------HNATFIILMEEGDLQRTNIQLDFG-DGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHVHLRVPFVAIRNKDVNISAVVWPS---------------------QLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTNTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHN-PDIPEWRQDIGNVIKRALIKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFT-------------------------EPEELLDKELDTRVIGSIATIASSESTKEIPNCTSV-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A2I9-1", "uniprot_id": "D4A2I9_RAT", "id": "D4A2I9-1", "name": "VPS10 domain-containing receptor SorCS3", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESAGTERP------AGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPGRLVSPASRPPALPPLLPRAAENRWPEELASARRAAAPRRRSRLELLSQASRG---EIPTEAAGTSPEGARWVRGIPA----PSQAGSARRTRRAQPPSTLERGDAWATAPADGAKGNRPQTKGSREEVKATLTGGSATEELRLPSTSFALTGDSAHNQAMVHWFGHNSSVILILTKLYDFNLGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGTTYQKYRLT--------FYIQSLLFHPKQEDWVLAYS--------------------------LDQKLYSSMDFGRRWQLMHERITPNRFYWSVSGLDKEADLVHMEVRSADGYAHYLTCR---IQECTETTRSGPFARSIDISSLVVQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLP-KDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRSLMGNIIIELYEVAGIKGIFLANK--------KVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHC-------------------LLPFCSLHLHLQLSENPYSSGRIS--SKDTAPGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGIETHIMTVFG-HFNLRSEWQLVKVDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRK----PGAQCALGREYSGSVTSEPCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQS-YLNSTGYRRIVSNNCTDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQG----------HNATFIILMEEGDLQRTNIQLDFG-DGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHVHLQVPFVAIRNKDVNISAVVWPS---------------------QLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTNTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHN-PDIPEWRQDIGNVIKRALIKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFT-------------------------EPEELMDKELDTRVIGSIATIASSESTKEIPNCTSV-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UPU3-1", "uniprot_id": "SORC3_HUMAN", "id": "Q9UPU3-1", "name": "VPS10 domain-containing receptor SorCS3", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAARTERP------AGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPA----PAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLT--------FYIQSLLFHPKQEDWVLAYS--------------------------LDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCR---IQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLP-KDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANK--------KVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHC-------------------LLPFCSLHLHLQLSENPYSSGRIS--SKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFG-HFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRK----PGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQS-YLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQG----------HNATFIILMEEGDLQRTNIQLDFG-DGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPS---------------------QLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHN-PDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFT-------------------------EPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q0Q0-1", "uniprot_id": "A0A8M9Q0Q0_DANRE", "id": "A0A8M9Q0Q0-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METALGVFPGAHFTISTWLILFFPNVKADISCAPCMSPMQVNYAGDEHLRDPPDSGKYPTPPDQKKPKLIAVLYPNIGVPTDGFPGIAPKVETNADGINSRAPLGNFAESALDEELFSDEFMESGRV----KRSVPEFMESARGADPLSEEQRK--TSALRVDGQGKRAEVRWNREDEQDARVSDSRPEEPKLTSSTFALAGDSAHNHAVVYWSGKNSSVILILTKLYDFHLGSVTESTLWRSTDYGSTYERLNDKVGVKTVLSYLYVCPTNKRKIMVLTDPEFESSILISSDEGASYQKYRLN--------FFVLSLLFHHTQEDWALAYS--------------------------HDQKLYSSFDFGRKWQLVHERVTPNRFYWSVTGLDKEFDLVHMEAHTPDGHCQYVTCR---AQACSESSRTHPFPGYIETNSLVVQDEYVFVQVTTTGRASYYVSYQREAFIRIKLPKYSLP-KDMHIVSTDQGQVFTAVQEWNQNDTYNLYISDTRGIYFTLALENVRTSRGLGGNSMIDLYEVAGIEGMLIANR--------KVENQVKTYITYNKGRDWRLLQAPSTDLAGNPIHC-------------------VLPFCSLHLQLQMSENPYLSGSIS--TKSSAPGVIVATGNIGSELSYNNVAMFISSDAGNNWRQIFEEEHNVWFLDKGGALVAVKQPTVPTRHLWISFDEGRQWTRHSFSAMPLFVDGVLVEAGAENQIMTFFG-HFSHRSEWQLIKIDYKSVFTRRCTEGDYQTWHLHNQGEPCIMGQKQIYMKRR----PGNYCMVGWDNSRILSAEPCICRAHDFECDYGFERRGDGNCLPAFWFNPSIVSRSCSQGQN-FLNSTGYRKVVANNCTKGVKEMYTARKQQCPNRPPRGLVLTTRDEKLTANMG----------SNVTFLVRLEEGDSMRTNIQLDFG-DGTAVSYSNLSWTQEGIKHVYRSAGIFRVTALAENSLGFDTSSLYLHVTCPVEHIQLLAPYVVIKNKEVNLTAVVWPS---------------------HFRTLTYFWWLGNSTEPIVTLDSSISHTFSSEGMSTVTVQVSSGDSILQDSRTIAIQEFFKSLLLSFSPNLDEAN-PDIPEWRLDVARVIKKAVLQVADVPEEQLLVAVFPGIPTAAELFLLPPRNQSNGRKQTEEDLEQISEILVNALNQISVEFELKPGSRVIVYITQLTLAPLVDSIPRHSSSAMLMLLSVVFLGLAVFLIYKFKRKIPWINIYAEVNHEKEQEMINTVGQNDATPKITLSEFS-------------------------TQKELMEKELEARAKR--GVIHTCESTREIPNCTSV-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7T6R5-1", "uniprot_id": "A0A8N7T6R5_DANRE", "id": "A0A8N7T6R5-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MINKKD------ALWFESSRTYWTLFCLCVLVPLPARAEITCASCFA-PIRRNEEALVEAKVKPSSDFGSVPDDSTDKNWIQALDG---AQLTSKAHRK-----SSSVSWREKLENAPKSSAEQ----TGEKGGKVYPTWSSEEIKVNRREKRSMFPPDHSPGSRFEFR--RTGGVDGIGKSPRQNEPHLITSTFALSGDSAHNQAMVLWSGHNSSVILILTKLFDFNLGTVTESSLWRSVDFGTTYEKLTDKVMIRTMLSYLYVCPTNKRKILILSDPEVESSLLISSDEGASFQKFNIN--------FYIMSLLFHPTQENWILAYS--------------------------HDQRLYSSVDFGKKWILVHERVTPGRFYWALSGLDKEADLVHIEARTDSGQMQYITCR---AQKCSEEGRQYPFIGRIDTNSLVVQDQYIFLQLTTAGRTTYFVSYQRGPFRTIQLPKYCLP-KDMHIVSTDEGQVLAAVQEWNENDTYSLYISDTPGVYFTRSLPNLRTSRGLAGNLIVDVYKVSGISGMIIANK--------KEDAQMRTYITYNKGQTWSLLQPPAKDTTGHDVNC-------------------NLPSCSLHLHLQMSENPYTPDTIS--TKQSAPGIIVATGNIGPELSFSNTAMFISSDAGNTWRQIFEEEHSVWFLDHGGALLAVTQSAVPTRYLWISLDEGRHWDKLSFSSTPLFVDGVLMTPETENRIITFFG-HFSYHSDWQLIKIDYSSLFGRKCTDGDFQTWHLHNKGEVCVMGERQVYMKRK----PGTRCTLGREYSRVVSAEPCICTLYDFECDYGFERQTSGKCAPAFWYDVNLPAHTCSYGQR-YRNSTGYRRVMLNNCREGLKDTLSPRMQQCKPIAPSGLQLSTINTQLTAVLG----------TNITFRVALQNGDSLSTSLHVDFG-DGISVSYSNISRLGDSITHTYRVAGIFRVSARAQNSQGSDSSSLYLHITSPVERIFLSAPVVVARGREANLTAVLWPS---------------------QPRTATFYWWFNNNTEPLITLEGSVSHTFTREGLNPVTVQVSAGGTVLQDVKIITVKDVFRSLLLSFSPNLEEHN-PSVAEWRQDVGRVVRATLAQVCSFPEDQLLVSVFPGSPTAAELFILPETNQSAFRSHTEEQLNKMSEVFMNALNQNLIQFDLKPDTRVTVSLSQLTLAPLVDSSVLPSGSAMLLLVSLGLLGLAILFIYKFKRKIPWIHVETEDSHEKEPEMISAVGQEKNGTRTTATSFTSCSAHNTHTPCPLNTGTHNSFSHLPPPRELMEKELEAHSTGGLGAGERLR-TRQIPNCTNV-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : .. ** : :. :: * . : : .* : . * * : . :...: : . : : : :. . : .:. :: . :::: : ", "identical_positions": 6, "similar_positions": 44, "identity": "0.37%" }, { "cls_id": "homologset.agr.HGNC:167", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P61163-1", "uniprot_id": "ACTZ_HUMAN", "id": "P61163-1", "name": "Alpha-centractin", "aln": "---MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRK-EGYDFHSSSEFEIVKAIKERACYLSINPQKDE-----TLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P85515-1", "uniprot_id": "ACTZ_RAT", "id": "P85515-1", "name": "Alpha-centractin", "aln": "---MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRK-EGYDFHSSSEFEIVKAIKERACYLSINPQKDE-----TLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P61164-1", "uniprot_id": "ACTZ_MOUSE", "id": "P61164-1", "name": "Alpha-centractin", "aln": "---MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRDVSRFLRLYLRK-EGYDFHSSSEFEIVKAIKERACYLSINPQKDE-----TLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P45889-1", "uniprot_id": "ACTZ_DROME", "id": "P45889-1", "name": "Actin-related protein 1", "aln": "---MEPYDVVVNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPMEHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRR-EGFNFRSTAEFEIVRSIKEKVCYLATNPQKEE-----TVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPDLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIAAPQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38696-1", "uniprot_id": "ARP1_YEAST", "id": "P38696-1", "name": "Centractin", "aln": "MDQLSDSYALYNQPVVIDNGSGIIKAGFSGEERPKALEYCLVGNTKYDKVMLEGLQGDTFIGNNAQKLRGLLKLRYPIKHGVVEDWDSMELIWSYVLNEVLQLQNIGEHPLLITEAPMNPLKNREQMAQVLFETFDVSALYVSNPAVLSLYASGRTTGCVVDCGEGYCSTVPIYDGFALPASMMRMDIGGADITEQLQFQLRKSAGVSLFSSSEREIVRTMKEKVCYLAKNIKKEEEKYLQGTQDLISTFKLPDGRCIEVGNDRYRAPEILFSPQIIGLGYDGLSDMCMQSIWKVDLDLRKPLLSSIILSGGTTTLKGFGDRMLWDLEALTKGTSKIKIIAPSERKYTTWIGGSILTGLSTFQRLWTKKSDWLEDSTR-VYSNLM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. .: ***********:*****:*:. ** :*..*: :** .*:** *:* :*:: ****.:***::**:* **:.** **.*: .: :**:*:****:** :***: *:.:** ::..**::* *******:**.** *:*.*:* :****:***:* *:**:**.* *::. *: :*: * .: *::* ***:::**:.***: * :*:* : : **** :*:* *:****:** *:::* :*: :: : :* * *:***: * ..*:****:* :******:* ::: : **:* **.** *:**:*****:.*.**:::* .* :: *:. : :: : :", "identical_positions": 167, "similar_positions": 121, "identity": "43.38%" }, { "cls_id": "homologset.agr.HGNC:16700", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A0R1-1", "uniprot_id": "D4A0R1_RAT", "id": "D4A0R1-1", "name": "Zinc finger protein ZFPM2", "aln": "MSRRKQSKPRQIKRPLEDAIEDEEEECPVEEADVIAKGDFPLEESFPTGFESENLSCEEVEFFCNKGDDEGIQEPAESDGDSHSDKPGQPGVETDDWDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVSMVLTAGPKWLLDVTWQGVEDSKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQTASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEE-----------------NEDSTHQISSLCPFPQCTKSFSNARALEMHLTSHSGVKMEEFLPPG---ASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPGGKLP-RESDMEHSPSGTEDSLQPATDLLA--RSDLSQSQKAMPTKDASSDTELDKCEKKTQLFLTNQRPEMQPAANKQNFSYTKIKSEPSSPRLASSPVQPNLG-PSFPVGPFLSQFAFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKG-------------ATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKIP---EALSPNTGQTSINLLNPAAHPPDPENPLLQTSCINSSTVLDLIGPNGKGHEKDFSTQAKKLPTSNNNDDKINGKPVDVKNPSGPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLSNPCSSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLAINKCVPVPKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTASPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPEVSFERNMIKCEKNGNPKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENKHLFLPQCLYPGAIKKTKGADQLSPYYGIKPSDYIAGSLVIHNTDVEQ--NTNTENESPKGQASSNGCAVPKKDSLPLLPKNRGMVIVNGGLKQDERPTANPQQENISQNAQHEDGHKSPSWISENPLAANENVSPG---IPCAEEQLSSIAKGVNGSTQAPSSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK----------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CCH7-1", "uniprot_id": "FOG2_MOUSE", "id": "Q8CCH7-1", "name": "Zinc finger protein ZFPM2", "aln": "MSRRKQSKPRQIKRPLEDAIDDEEEECPVEEAEVISKGDFPLEGSFPAGFEPENLSCEDVEFFCNKGDDEGIQEPAESDGDSHSDKPGQPGVETDDWDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYSKGGQLWCTTTKAISEGEELVAFVVDFDSRLQAASHMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEE-----------------NEDNSHQVSSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPG---ASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLP-RESDMEHSPSGTEDSLQPATDLLA--RSDLSQSQKAMPTKDASSDTELDKCEKKTQLFLTNQRPEIQPAANKQNFSYTKIKSEPSSPRLASSPVQPNIG-PSFPVGPFLSQFAFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKG-------------ATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMP---EAVSPNTGQTSINLLNPAAHSSDPENPLLQTSCINSSTVLDLIGPNGKGHEKDFSTQVKKLPTSNSSDDKINGKPVDVKNPSGPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLSNPCSSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLAMNKCVPVPKCDTTHSNVSCLEMDVPIDLSKKCLSQSERTTASPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERSSPEVSFERNMIKCEKNGNPKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENKHLFLPQCLYPGAIKKTKGADQLSPYYGIKPSDYIASSLVIHNTDVEQ--STNTENESPKGQASSNGCAVPKKDSLPLLPKNRGMVIVNGGLKQDERPTANPQQENISQNTQHEDGHKSPSWISENPLAANENVSPG---IPCAEEQLSSIAKGVNGASQAPSSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK----------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WW38-1", "uniprot_id": "FOG2_HUMAN", "id": "Q8WW38-1", "name": "Zinc finger protein ZFPM2", "aln": "MSRRKQSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEESFSTEFGPENLSCEEVEYFCNKGDDEGIQETAESDGDTQSEKPGQPGVETDDWDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEE-----------------NEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPG---ASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLP-RESDMEHSPSATEDSLQPATDLLT--RSELPQSQKAMQTKDASSDTELDKCEKKTQLFLTNQRPEIQPTTNKQSFSYTKIKSEPSSPRLASSPVQPNIG-PSFPVGPFLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKG-------------ATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMP---EALSPNTGQTSINLLNPAAHSADPENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNNDDKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPDVSYERSIIKCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRHLFLPQCLYPGAIKKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQ--SRNAENESPKGQASSNGCAALKKDSLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWISENPLAANENVSPG---IPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK----------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R4T3-1", "uniprot_id": "F1R4T3_DANRE", "id": "F1R4T3-1", "name": "", "aln": "MSRRKQSNPRQIKRPLDGGLEEEEEECISDANELAAKEEFSAEENFPADFEPDNLTCEDMEYFCGKGEENGNREMGETEMETDSEKTRHPPLEPEEWDGPRELDLFNKDGERRIHSRQQLPVGTTWGPFEGKIELNTDAQKTKPHVPLVLNAGPRWLLDVTWQGTDDNKNNCVVYSKGGQLWCTTTKNMMEGEELVAFAVDFDSRLQAVNHMSLGEGMYPARLLDTIQLLPQQAAMASILPTAIVNKDIFPCKACGIWYRSERNLQAHLMYYCSGRQREPDNVPEE-----------------TDAISHQTPSICPFPQCNKSFSNPRALEMHLSSHSSVKMEETLPPG---TSLKCTICNFTADSLLTFQHHILSHLSQAAFRCNHCHISFQNHRELLQHQDLHGHSGKIH-RESDSENSPRGGEDSLQAARAELSGRKDIVMQSPKNTPNKANSPDGELERPEKKPTLGLQ--KGDSHPGS-KASFSYTRIKSEPSSPRLASSPVQHNMG-PTFPMGPFLSQFAFSQDISVVPQASEILAKMSELVHRRLRHGGNSYPPVIYSPLMPKG-------------ATCFECNITFNNLDNYLVHKKHYCNSRWQHMTKSPDFSSVPDKVS---DAISPNSGHTSVGML-PGCLPSDTDSHVVTTACLNSS-VLDIMNAGGKVPEKELTGQVKKVTTPTGVEERLGGKQPEVKSPSTSLVDGDSDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPMKR-MSAKVPAMQRTMRTRKRRKMYEMCLPEDQRQPMGPQPGFLSLHTLGNPCTS-QETVENLADRFHPRCDIFPGLVPKHLDASLTITKSILAPKGNTVADPQ---ELDAPIDLSKKCSPLPDKSCNSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAAHG-EVGNLEQPIFPGMKTEGNNADDVYDKSSVKCEKNGGNK-LMQNGGMFPPHLGSAPDLKAFAD-AQLMSSKDENKNMFLPHSLYPGAIKKVKGTEQISPYFGIKSGDYMAGSLVVQAEAAEQEQSSNGAGEPGTESLAANGCPHPNKDPLPLLPKNRSMVIVNGGHKEDRQTPATPQQENQPHNTSLPEEQTSPTWGAENPPDPNENVSPT---SKSPVEDSAPAGKGINGSASPAGSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK----------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VPQ6-1", "uniprot_id": "USH_DROME", "id": "Q9VPQ6-1", "name": "Zinc finger protein ush", "aln": "--MLSSNTRGDCSDTAEEMTVDSRDSKDLSAQDIGEQKQQQMEDQLEDQLN-------------DSRDPQNNNNNIDDDADEDAEFEEPEKANPQQDQDLGETEMEQEHDLQQEDLQQELPANSPSTPPR---SPSSPQLIPKLEQPATPPS-------------EPEASPCPSPSP-----CPTPKYP--KVRLNALLASDPALKPDAKELTLPD----SRLLAPPPLVKPDTQAQPEVAEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRIKDTDEAGSDKSGAGGSGATAGDAAGLTGGSTEPPAKMARTGKQYGCTQCSYSADKKVSLNRHMRMHQTSPAAPTLAGLPSLLQNGIAPPGVTPNPMEDSSSQQTDRYCSHCDIRFNNIKTYRAHKQHYCSSRRPEGQLTPKPDASPGAGSGPGSAGGSIGVSAQAATPGKLSPQARNKTPTPAMVAVAAAAAAAAASLQATPHSHPPFLALPTHPIIIVPCSLIRAASFIPGPLPTPNSGIVNPETTCFTVDNGTIKPLATALVGATLEPERPSAPSSAAEATEAKSSPPEPKRKEAGLTRESAPLDLSLRRSPITLNSLSLRQRQLRNALLDVEEVLLAGVGTGKENVETPRGGGSVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGAGSASSMSPPGLNVAVPHLLDMRSMLPADFGLSESLLAKTNPELALKLAAAAAAAAVAGSSGAAAFPPASLPAQTSSGNPGSGGSAGGAQQPQIYVKKG--VSKCMECNIVFCKYENYLAHKQHYCSARSQEGASEVDVKSAVSPSIAGAGGLGAGAAEAASSVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAVAAPAATPTDPGQLGMPKEKCGKCKTLHEIGLPCPPPVANPLAAPTVNPQPATNSLNKCPVCGVVSPTAALAKKHMEMHGTVKAYRCS-ICQYKGNTLRGMRTHIRTHFDKKTSDVNEELYMTCIFEEDASALSQELVTPTGASTTTGHDSMDHPSQMFNCDYCNYVSTYKGNVLRHMKLMHPHVAINSPSISPDTRDQDVTSNPTTNQHSNSDVSNGEAPSFHIKSEPLDPPPTVNLVHENNNSPIATPHIKAEPIEVGADAAPGGLVPPMTSPLGNSSSVAAAAAAAAEVMKKYCSTCDISFNYVKTYLAHKQFYCKNKPIRPEASDSPSPNHLGGGVAVGLGIGGLVGGHGQQKNKENLQEAAI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .... : . . : :..:. . :: : : * .: : .. : :. .: : : : .:: :.:: :. * :: :... :: . :*:**..:. * . .. .* . . . : : . . * * *.*.* .* *: .. : ...::* : :*** . *: :: . :. .::: * * .*** : * .*:** **** * ::. . .: . :. ..:. : . . . : : ::. : ::*.: *.. :.* . : . * . :. : * *: *.**.: *:. : *:: : . : : : .:. . .. .* : . . : :. : . : :. . :. * *.* *:* : : *. : : :: :: * *: ::. * : .. . . . ** ** : .. **:*.*. : :: . : : . . : . :::*: : .: . . ..... : . . .:. . .: .. : .: . :.: . .: : .* . . . . : :: *. . * : .: .. : * :.: *. . ** *...:: . . : .. :. . .*. .. . : : : .. : . .: . . . : . :: . : :. .. * .* : : : : * . : . :*. * .* : . . : : . :*: : . : * . ....* :.:. : ** . : .: : . . :.: .. . :... * . . . . :. . . . : :.. :* . :.:* . . . . .:: . *** ***.** :..:::**:***..:. . ", "identical_positions": 99, "similar_positions": 390, "identity": "8.01%" }, { "cls_id": "homologset.agr.HGNC:16701", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8L2UJI1-1", "uniprot_id": "A0A8L2UJI1_RAT", "id": "A0A8L2UJI1-1", "name": "", "aln": "MDLTATMSSKR--AKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASMGKNPTDEYLDAMMNEAPG--------PINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEAIGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3THE2-1", "uniprot_id": "ML12B_MOUSE", "id": "Q3THE2-1", "name": "Myosin regulatory light chain 12B", "aln": "------MSSKK--AKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPG--------PINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P19105-1", "uniprot_id": "ML12A_HUMAN", "id": "P19105-1", "name": "Myosin regulatory light chain 12A", "aln": "------MSSKR--TKTKT-KKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLDAMMNEAPG--------PINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P40423-1", "uniprot_id": "SQH_DROME", "id": "P40423-1", "name": "Myosin regulatory light chain sqh", "aln": "------MSSRKTAGRRATTKKRAQRATSNVFAMFDQAQIAEFKEAFNMIDQNRDGFVEKEDLHDMLASLGKNPTDDYLDGMMNEAPG--------PINFTMFLTLFGERLQGTDPEDVIKNAFGCFDEENMGVLPEDRLRELLTTMGDRFTDEDVDEMYREAPI-KNGLFDYLEFTRILKHGAKDKDEQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06580-1", "uniprot_id": "MLC2_YEAST", "id": "Q06580-1", "name": "Myosin light chain 2", "aln": "----------------------MDHSESLTFNQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTSTAEVGEEGVSFPIFLSIMGKNLSQFPEREELEESLKAIGRGHDLNVPLNEVIDSLKEAGFENPEEEFAKLFKLFTTNQQATEERTFRGKLFLDSITD----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::: * .* : * * ::*:**:*:*::.**::.: ** .: *::**. ** . *: : :.*.:**:::*:.*. .: :.::: .:.. : : : : *. * . .:*:. :::: . ::. : ::: .. .* ", "identical_positions": 28, "similar_positions": 71, "identity": "14.81%" }, { "cls_id": "homologset.agr.HGNC:16702", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q68FS2-1", "uniprot_id": "CSN4_RAT", "id": "Q68FS2-1", "name": "COP9 signalosome complex subunit 4", "aln": "MAA-------AVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKVQPRVISFEEQVASIRQRLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88544-1", "uniprot_id": "CSN4_MOUSE", "id": "O88544-1", "name": "COP9 signalosome complex subunit 4", "aln": "MAA-------AVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BT78-1", "uniprot_id": "CSN4_HUMAN", "id": "Q9BT78-1", "name": "COP9 signalosome complex subunit 4", "aln": "MAA-------AVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P0H6-1", "uniprot_id": "CSN4_DANRE", "id": "Q6P0H6-1", "name": "COP9 signalosome complex subunit 4", "aln": "MAS-------GVRQELAQLMNSSGSHKDLAGKYRQILEKALQFTDAEQLEALKAFVEAMVNENVSLVISRQLLTDFCAHLPNLPDDIAKVVCHFTLEKIQPRVISFEEQVASIRQHLATIYEKQEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHETERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPPAKAEKIASQMITEGRMNGFIDQIDGIVHFETREPLPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAIEAQMSQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V345-1", "uniprot_id": "CSN4_DROME", "id": "Q9V345-1", "name": "COP9 signalosome complex subunit 4", "aln": "MAANYGISTAALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILNDVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELSYRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFENRELLPQWDRQIQSLCYQVNSIIEKISVAEPDWMDNLN------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: .:*.:* *:* :*:*** *.****:*:..: :. * ::.*: ****:***:********:*.*. :.*.:***. :* : ******::***********.** :**.***::::**:** **************.*: ** ************:*.**** :******** *:..*:**: ***************************:.**.: **: ***:** **:**********************:*.**********:**** .:**** *:* ****:*:**********:***********************:**..*****************.****..*****.** ** **:******:***.::**** : *:* : ", "identical_positions": 282, "similar_positions": 83, "identity": "68.28%" }, { "cls_id": "homologset.agr.HGNC:16703", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JI12-1", "uniprot_id": "VGLU2_RAT", "id": "Q9JI12-1", "name": "Vesicular glutamate transporter 2", "aln": "---MESVKQRILAPGKEGIKNFAGKSLGQIYR-------VLE------KKQDNRETIELTED--GKPLEVPEKKAP-------LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP--EE-------------TSEEKCGFIHE---------DELDEETGDITQNYINYGTT---------KSYGATSQENGGWPNGWEKKEEFVQESAQD-AYSYKDRDDYS--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BLE7-1", "uniprot_id": "VGLU2_MOUSE", "id": "Q8BLE7-1", "name": "Vesicular glutamate transporter 2", "aln": "---MESVKQRILAPGKEGIKNFAGKSLGQIYR-------VLE------KKQDNRETIELTED--GKPLEVPEKKAP-------LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISDGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP--EE-------------TSEEKCGFIHE---------DELDEETGDITQNYINYGTT---------KSYGATSQENGGWPNGWEKKEEFVQEGAQD-AYTYKDRDDYS--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P2U8-1", "uniprot_id": "VGLU2_HUMAN", "id": "Q9P2U8-1", "name": "Vesicular glutamate transporter 2", "aln": "---MESVKQRILAPGKEGLKNFAGKSLGQIYR-------VLE------KKQDTGETIELTED--GKPLEVPERKAP-------LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADP--EE-------------TSEEKCGFIHE---------DELDEETGDITQNYINYGTT---------KSYGATTQANGGWPSGWEKKEEFVQGEVQD-SHSYKDRVDYS--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5W8I7-1", "uniprot_id": "VGL2B_DANRE", "id": "Q5W8I7-1", "name": "Vesicular glutamate transporter 2.2", "aln": "---MDTVKERVLAPGKEKMRNLAGKTLGHMHR-------VME------RKQKTGEVIELTED--GRPMHMPEKKAP-------LVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHKGGKIIIKGKAKFNWDPETVGMIHGSFFWGYTVTQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARVHYG-CVMFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGILVQYSGWSSVFYIYGSFGIVWYMFWILVSYESPADHPTITDEERTYIEESIGESAKLLGAMEKYKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMVSALPHLVMTIIVPIGGQLADYLRSKNILTTTTVRKIMNCGGFGMEATLLLVVGFSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKNKTREEWQNVFLIASLVHYGGVIFYGIFASGEKQPWADP--EE-------------TSDEKCGFIDE---------DELAEETGDITLSHAPFGAQGALG--APAKTYGATTQLNGGWAKGWEKTEEFIQEDAER-TYTG---DGYS--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q5W8I8-1", "uniprot_id": "VGL2A_DANRE", "id": "Q5W8I8-1", "name": "Vesicular glutamate transporter 2.1", "aln": "---METPRE-PAGFSKEGLKQLAGKTLGHVYR-------VIE------KRQKPGENIELTED--GRPAQINERKAP-------LCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTIHLNGKIIIKEKAKFNWDPETVGLIHGSFFWGYIVTQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARGHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGCFGIFWYMFWILVSYESPAEHPTITAEERCYIEESIGESAKLLGPADKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSALPHLVMTIIVPIGGQLADHLRSKNILSTTTVRKIMNCGGFGMEATLLLIVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGIFASGEKQPWADP--EL-------------TSDEKCGFIDE---------DELAEETGDITQSYGALGAP--------AKSYGATTQLNGGWAEGWDKREEYVQDGVEEGGYGYRQGGNYS--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQC0-1", "uniprot_id": "Q9VQC0_DROME", "id": "Q9VQC0-1", "name": "", "aln": "MKGLTAFKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVF------------MNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKT-TPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFGAPEYTEQSQMQQSTAISYGATGHVANNPFAMASGAPPIAEEDAPPTYGDVTNPGQYGYTQGQMPSYDPQGYQQQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : :: . :: :.: :: :* : . : :* . * . * : * .. * :* ** ** *: :** *:**:***:..* :. :*.*:. :** . . :..****** :******:*:*::.**::** :*: ::**::::* * :* *: **:****.************ ****:******* :*.*****.*:.:**:*:*.: *:.: ** ** **:.*****: :.:*.* .**:*: * ***:*:****: . * ****::: ****************.****:: *.::::. ***::.:.*::.::***:** ***:** :**.**.: **:**.***::********. ::*.*..* : *: *. .*.********:*****************:*:*:***:*:: * :..: : :. * ** :*: ** * **.:***** ****:* * *. .:.*:: : * *:: . *: : **.. : . . : . : * .*. ", "identical_positions": 242, "similar_positions": 174, "identity": "37.52%" }, { "cls_id": "homologset.agr.HGNC:16704", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62634-1", "uniprot_id": "VGLU1_RAT", "id": "Q62634-1", "name": "Vesicular glutamate transporter 1", "aln": "MEFRQEEFRKLAGRALGRLHRLLEKRQE---------GAETLELS-ADGR-----------------PVTTHTRDPP-------VVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEP---------------EEMSEEKCGFVGHDQLAG--------SDESEMEDEVEPPGAPPAPPP-----SYGA-----------------THSTVQPPR---PPPPVRDY----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TXX4-1", "uniprot_id": "VGLU1_MOUSE", "id": "Q3TXX4-1", "name": "Vesicular glutamate transporter 1", "aln": "MEFRQEEFRKLAGRALGRLHRLLEKRQE---------GAETLELS-ADGR-----------------PVTTHTRDPP-------VVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEP---------------EEMSEEKCGFVGHDQLAG--------SDESEMEDEAEPPGAPPAPPP-----SYGA-----------------THSTVQPPR---PPPPVRDY----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P2U7-1", "uniprot_id": "VGLU1_HUMAN", "id": "Q9P2U7-1", "name": "Vesicular glutamate transporter 1", "aln": "MEFRQEEFRKLAGRALGKLHRLLEKRQE---------GAETLELS-ADGR-----------------PVTTQTRDPP-------VVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEP---------------EEMSEEKCGFVGHDQLAG--------SDDSEMEDEAEPPGAPPAPPP-----SYGA-----------------THSTFQPPR---PPPPVRDY----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3ANT7-1", "uniprot_id": "A0A8M3ANT7_DANRE", "id": "A0A8M3ANT7-1", "name": "Vesicular glutamate transporter 1", "aln": "MEVRPERFKAVAAKTLGRINRVLEKRQE---------NGETIELS-AEGR-----------------PELQEEKELP-------VVDCTCFGLPRRYIIAILSGLGFCISFGIRCNLGVAVVSMVNNHTVYRDGKPYIVKAQFSWDPETVGMIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAVVSTSILNMMIPTAARMHFG-CVILVRILQGLVEGVSYPACHGIWAKWAPPLERSRLATTAFCGSYAGAVIAMPLAGVLVQYSGWSSVFYVYGSFGVCWYLFWILVSYESPAAHPTITPEERKYIEDAIGESAGLVNPLTKFNTPWRQFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFKFEISKVGILSALPHLVMTIVVPIGGQLADYLRTHNLMTTTNVRKLMNCGGFGLEATFLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKNKTREEWQYVFLIASLVHYGGVIFYGLFASGEKQPWAEP---------------ENTSEEKCGILGEDELAD--------ETEELYRSAGGGYGATMQSGD-----PNGAGTGGGGAGGSWVSDWDKTEEYVQPVG---TNSFLYGGEEGRGMNE--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQC0-1", "uniprot_id": "Q9VQC0_DROME", "id": "Q9VQC0-1", "name": "", "aln": "MKG-LTAFKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRGPGGGHAYDDDDDRPDSPASFEEIERPPLRKIDKYCKAECPCMPARYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVFMN-----------WTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKT-TPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFGAPEYTEQSQMQQSTAISYGATGHVANNPFAMASGAPP--------------IAEEDAPPTYGDVTNPGQYGYTQGQMPSYDPQGYQQQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: *: * .:* :: :** : . * :* . :** * . : * .. * :* ** ** :: :** *:**:***:..* :. :* *.. . * . . :..******:*********..**.**::**:::*::: *::::* * : .* ** **:****.***:******** ****:******* **.*****.*:.:**:*:*.: *:.: **.** **: **:**: :.:*.* **:*: * ****.::**** * * ****.:: ****************.****:: *.::::. * *::.:.*::.:****:** :**:** :**.**.. :::*******:******:*. ::*.*..* : *: *. .*.********:*****************:***:***:*:: * :..: : :. * ** :*: ** * ***:***** ****** : . .:.*::*. . .. .. **. . ** :.. * . . . ", "identical_positions": 248, "similar_positions": 164, "identity": "37.63%" }, { "cls_id": "homologset.agr.HGNC:16705", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6PB75-1", "uniprot_id": "PAPD7_MOUSE", "id": "Q6PB75-1", "name": "Terminal nucleotidyltransferase 4A", "aln": "MDPRVAWIQPEQKGPANALWMQIWETSQG---------------VGRGGSGFAS-------YFCLNSPALDTAAAPGAAGRAAPAAGGPGPAPAASSPPP--APGPAALPPALLTALGPAADSARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSTSLGRAGSGR--TFFSFADGA----------AHAHPGPRGSTPAGSPPQHQFHPGRRKRENKASTYGLNYLLSGSRAATLSGGGGPGAQAARPGTPWKSR--AYSPGIQG---LHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTS-DIDLVVFG----KWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFN-METGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFT-GGISSYSLILMAISFLQLHPRIDARRAD--ENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLS-HAVSPLARSYPNRDSESTLGRIIKVTQEVIDYRRWIKEKWG-----SRILPSPDLDNRIKIKERIT---------------------------------TCNGEQMQSREPSSPYTQRLTLSLSSP-------------------------------------QLLSSGSSASSVSSLSGSDIDSDTPPCTTPSVYQFSLQAPTTLMASLPTALPMPSSKPQPAASRTLIMTTNNQTRVTIPPPTLG-VAPVPCRQAG------------------------------------------------------------------------VDGTTSLKAVHSVTSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHNHTQGGGYSSVGSGAVRPPVGNRGHHQYNRTGWRRKKHAHTRDSLPVSLSR-------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZSY1-1", "uniprot_id": "D3ZSY1_RAT", "id": "D3ZSY1-1", "name": "Terminal nucleotidyltransferase 4A", "aln": "MDPRVAWIQPEQKGPANALWMQIWETSQG---------------VGRGGSGFAS-------YFCLNSPALDTAAAPGAAGRAAPAAGGPGPAPAASSPPP--APGPAALPPALLTALGPAADGARRLHKSPSLSSSSSSSS-NAESGTESPGCSSSSSSSTSLGRAGSGR--TFFSFADGA----------AHAHPGPRGPTPAGSPPQHQFHPGRRKRENKASTYGLNYLLSGSRAATLSGGGGPGAQAARPGTPWKSR--AYSPGIQG---LHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTS-DIDLVVFG----KWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFN-METGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFT-GGISSYSLILMAISFLQLHPRIDARRAD--ENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLS-HAVSPLARSYPNRDSESTLGRIIKVTQEVIDYRRWIKEKWG-----SRIVPSPDLDNRIKIKERVT---------------------------------TCNGEQMQSREPSSPYSQRLTLSLSSP-------------------------------------QLLSSGSSASSVSSLSGSDIDSDTPPCTTPSVYQFSLQAPTTLMAGLPTALPVPSSKPQPAASRTLIMTTNNQTRVTIPPPTLG-VAPVPCRQAG------------------------------------------------------------------------VDGTTSLKAVHNVTSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHNHTQGGGYSSVGSGAVRPPVGNRGHHQYNRTGWRRKKHAHTRDSLPVSLSR-------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5XG87-1", "uniprot_id": "PAPD7_HUMAN", "id": "Q5XG87-1", "name": "Terminal nucleotidyltransferase 4A", "aln": "MDPRVAWIQPEQKGPANALWMQIWETSQG---------------VGRGGSGFAS-------YFCLNSPALDTAAAAGAAGRGS---GGLGPALPAASPPPPGPTAPAALPPALLTALGPAAEGARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGGGRGGAFFNFADGAPSAPGT----ANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLNYLLSGSRAAALSGGGGPGAQAPRPGTPWKSR--AYSPGIQG---LHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTS-DIDLVVFG----KWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFN-METGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFT-GGISSYSLILMAISFLQLHPRIDARRAD--ENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLS-HAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWG-----SKAHPSPGMDSRIKIKERIA---------------------------------TCNGEQTQNREPESPYGQRLTLSLSSP-------------------------------------QLLSSGSSASSVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPPPTLG-VAPVPCRQAG------------------------------------------------------------------------VEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR-------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58I0Y0-1", "uniprot_id": "A0AC58I0Y0_DANRE", "id": "A0AC58I0Y0-1", "name": "Terminal nucleotidyltransferase 4A", "aln": "MDPRVAWIQPEQKGPANALWMRVWETSQ----------------VNRTNTGQHQNHHHHHHNFCVNSPAFDVYKTVASNANNSTNIKNNGTAIPGSGSAVLALNGNAVDGEMSQKTGGSVVDSASSCTRIR--TTSPNVIAGNMNKGQPFFTLNESVLNNVNHHHHPPHPHLRHFHQEQQS-----------CMKRHPSYPTAIHNHHHHHHHPGRRKSDNKASTYGINYLLSN-----WTNG-----NYESSGTPWKTR--KYSPGVDG---LHEEIMDFYNFMSPRPEEATMRQEVVDRIESVIKELWPTADVQIFGSFSTGLFLPTSSDIDLVVFG----KWEKPPLQQLEQALRKHSVAEPYSIKVLDKATVPIIKLTDQETEVKVDISFN-VETGIKAASFIKEYVKKYTVLPYLIFVLKQFLLQRDLNEVFT-GGISSYSLILMVISFLQLHPRIDTRNPN--MNLGILLIEFFELYGRHFNYLKTGIRIKNGGAYMAKEDIMKAMSNGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKEAFDYAYIILS-HAVSPLARSYPNKDSDSTLGRIIKVTQEVIDYREWIIKKWGG-RHNSRIERNPGSSHKEHVDQVETGSLL-----------------------------GVGVEEQQQRDSVSPHSADSPMSLSSP-------------------------------------QQHSS---ASSASSLSGSDIDSDSTPYVAPPVAPFPLQILAP--GPLPPALQMG----KASIAAALGMPPVTQARVSIPG-NLS-LHTLPGRQVC------------------------------------------------------------------------MADGP--PSYLHMPPPAVPPAPPSPLPSP--LHHPKAGPKFPLKGFHNP------AVVHS----PVLSNRGHIQYNRNTWRRRK----RDSLPASVSR-------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7KVS9-1", "uniprot_id": "TRF41_DROME", "id": "Q7KVS9-1", "name": "Non-canonical poly(A) RNA polymerase protein Trf4-1", "aln": "MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIG---LHEEIEHFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTS-DIDLVVLG----LWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFN-MQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFT-GGISSYSLILMCISFLQMHPRG--IYHDT-ANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLA-LAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLRVGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAISIISISSESSIASSSSSSSRSGQDQQRDER", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VC07-1", "uniprot_id": "TRF42_DROME", "id": "Q9VC07-1", "name": "Inactive non-canonical poly(A) RNA polymerase protein Trf4-2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCDEAN-----------------------------------------------PAKPWQLPDVVYGNGIPALCLLHQEIEQFYNYIRSTPTEFCLRAGAVRRIEDVVLSIWPSASVDLFGSFRTGLNLPDS-DIDLVVYYK---FWNPRLLHELQNELVSQGVTDPDTVTVLDKASVPVVKFTDLISRIRFDVTFNSVASGVQAADLIKDFIRHFPELPKLVMVLKQFLSLHGFNEVYNSGGVSSYALTLMVISFLQQHARSNRRLSEH-SKLALLLIQFLDYYGRKFDFFKYGISVLGQGGCVEKARLRSTLGENNWQSVLCIEDPVTPTNDIGRSSYGVLGVMQGFGAAFVKLS-KLVD----SDSSKIVGPILANIVEVPQSIINYRAWVHYNFQHLLTPE----LPCADS-----------------------------------------------------LVQPSPTGSTS---------------------------------------------------PSASASASEDERSG------------------------------------GPAT-------IGFGRCDDPPQNIDIVADLANLKMN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53632-1", "uniprot_id": "PAP2_YEAST", "id": "P53632-1", "name": "Poly(A) RNA polymerase protein 2", "aln": "------------------------------------------------------------MGAKSVTASSSKKIKNRHNGKVKKSKKIKKVRKPQKSISLNDENEVEILPSRNEQETNKLPKDHVTADGILVLEHKSDDDEGFDVYDGHFDNPTDIPSTTEESKTPSLAVHGDEKDLANNDD--------FISLSASSEDEQAEQEEEREKQ-------ELEIKKEKQKEILNTD-------------------YPWILN-HDHSKQKEISDWLTFEIKDFVAYISPSREEIEIRNQTISTIREAVKQLWPDADLHVFGSYSTDLYLPGS-DIDCVVTSELGGKESRNNLYSLASHLKKKNLAT--EVEVVAKARVPIIKFVEPHSGIHIDVSFE-RTNGIEAAKLIREWLDDTPGLRELVLIVKQFLHARRLNNVHT-GGLGGFSIICLVFSFLHMHPRIITNEIDPKDNLGVLLIEFFELYGKNFGYDDVALGSSDGYPVYFPKSTWSAIQPIKNPFSLAIQDPGDESNNISRGSFNIRDIKKAFAGAFDLLTNRCFELHSATFKDRLGKSILGNVIKYRGKARDFKDERGLVLN----------KAIIENENYHKKRSR---------------------------------------IIHDEDFAEDTVTSTATATTT-------------------------------------------DDDYEITNPPAKKAKIE------------------------------------------------EKPESEPAKRNSG----ETYITVS------------------------------------------------------------------------SEDDDE--------------DGYNPYTL-----------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P48561-1", "uniprot_id": "TRF5_YEAST", "id": "P48561-1", "name": "Poly(A) RNA polymerase protein 1", "aln": "--------------------------------------------------------------MTRLKAKYSPTKGKRKEDKHTKRMRKSSFTRTQKMLEVFNDN----RSHFNKYESLAIDVEDDDTFGNLVLMENDKSDVDIPVIE-------EVTSSEDEQRAESSKRN---NSLEDNQD--------FIAFSDSSEDETEQIKEDDDERSSFLLTDEHEVSKLTSQQSLNTES-------------ACNVEYPWIRN-HCHSKQRRIADWLTSEIKDFVHYISPSKNEIKCRNRTIDKLRRAVKELWSDADLHVFGSFATDLYLPGS-DIDCVVNSRNRDKEDRNYIYELARHLKNKGLAI--RMEVIVKTRVPIIKFIEPQSQLHIDVSFE-RTNGLEAAKLIREWLRDSPGLRELVLIIKQFLHSRRLNNVHT-GGLGGFTVICLVYSFLNMHPRIKSNDIDVLDNLGVLLIDFFELYGKNFGYDDVAISISDGYASYIPKSCWRTLEPSRSKFSLAIQDPGDPNNNISRGSFNMKDIKKAFAGAFELLVNKCWELNSATFKDRVGKSILGNVIKYRGQKRDFNDERDLVQN----------KAIIENERYHKRRTR---------------------------------------IVQEDLFINDTEDLPVEEIYK-------------------------------------------LDEPAKKKQKAKKDKREGEIKKSA-----------------------------IPSPPPDFGVSRSKLKRKVKKTDQGSLLHQNNLSIDD-------------------------------------------------------------------LMGLSENDQESDQDQKGRDTPSGQDEKSPLETKTVDAQTRRDYWLSKGQAL----------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** :. * ** .* :: . * * .: :. .: .:*. * :.:***: *.* ** * *** ** . : * * .:.:: : *: *: **::*: : : ::.*::*: .*:.:*.:*:.: . . * *::::**** : :*:*.. **:..::: : ***: *.* : :*.:**::*:: **:.*.: . .: : *.*:** *::.*.*:. : : * *: * . . . *..::. . ::. . . . ... . ", "identical_positions": 68, "similar_positions": 116, "identity": "6.7%" }, { "cls_id": "homologset.agr.HGNC:16708", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q566R4-1", "uniprot_id": "LRA25_RAT", "id": "Q566R4-1", "name": "Leucine repeat adapter protein 25", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGLPS--TEAPGGAGCALAGLPPLPRGLS-----------------------------GLLNASGGSWR-----ELERVYSQRSRIHDELSRAARAPDGP---------RHAAGSANLGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLS-SSLHSDSSYPPDAGLSDDDEPPDASLP-----------------------------------------------------PDPPPLTVPQ-THNARDQWLQDAFQISL----------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QUI1-1", "uniprot_id": "LRA25_MOUSE", "id": "Q9QUI1-1", "name": "Leucine repeat adapter protein 25", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGLPA--TEAPGGAGCALAGLPPLPRGLS-----------------------------GLLNASGGSWR-----ELERVYSQRSRIHDELSRAARAPDGP---------RHAAGSANSGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLS-SSLHSDSSYPPDAGLSDDEEPPDASLP-----------------------------------------------------PDPPPLTVPQ-THNARDQWLQDAFQISL----------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N5H3-3", "uniprot_id": "LRA25_HUMAN", "id": "Q8N5H3-3", "name": "Leucine repeat adapter protein 25", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGLPS--AEAPGGAGCALAGLPPLPRGLS-----------------------------GLLNASGGSWR-----ELERVYSQRSRIHDELSRAARAPDGP---------RHAAGAANAGPAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSFCQDLS-SSLHSDSSYPPDAGLSDDEEPPDASLP-----------------------------------------------------PDPPPLTVPQ-THNARDQWLQDAFHISL----------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1QV06-1", "uniprot_id": "A0A8M1QV06_DANRE", "id": "A0A8M1QV06-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGFQCSPAECPAGSVCPVEGLPPLPKGLS-----------------------------GILNSSGGSWR-----DIEKVYSKRTRIQADISKS-RVSDCL---------ERSK-------------PASLDAALAVLRKDMVGLRQLDMSLLCQLWSLYESIQEYKGAFQDIS-SSLCE-SSFNTENGYSEEE---EEEDEDDHEAE-----------------------------------------------------RGDTPLSFPQPAQNSRDQWIKDSFHIPI----------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLJ5-1", "uniprot_id": "Q9VLJ5_DROME", "id": "Q9VLJ5-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMENSSNDAQPHLTGLPP-LPKSLSAATAAPVAIGPHPRTASPASSVNALTVAAGELYLGPSTSSSAASRNRSYNGHGHSQR-----HGSLSSTQESLSDRESVHSRASSTHS---------AGAVHTPTNSSSSTGATSSTIDNQLAILRREMYGLRQLDLSLLSQLWALNESIQGFRVFLQEQDALSPPS-RSRTPSDANSLSSDEEDDGSYAPVALPKMTDTAGAGSAGVVNSRAMASPAASGGLPTKLATGSTTSHASTSSTSGASGSSSAASSMGKHQQVQQQQQQQSQSANHYHQRPAPPPAPPAQHKAHPQLPRILQQRMRQAPPPPPPTR------------QKAGGGGGGGASTSSSNHSISSVTQPHPHSHQHPQHTHHSRPV--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0ACA5YM07-1", "uniprot_id": "A0ACA5YM07_DROME", "id": "A0ACA5YM07-1", "name": "", "aln": "MATTAAGSAATTTNTMVVKRPGPPVPPRPKAAAQLANGAGAPPIIQKKPTFVSQLSAVGRTLVYKSPTVNLPKKQAQTQTPTTAVPTPPVKPLKLRKAPDVPTAKPRDSMTSVVTVNRHNSISVIGSTPQTTPRKDTRLSLGKVDFERAGLQPASQPLPRPRKIVQVPVATLDVEDIPVVAPSPSSNGLFRRSKTTLDGSQKDSASSPHNGGGFLSGRTVEIKNNLKNAAERLFSEIIINQSQKQAATDTTIITKHEALKQESDVLAIQSSGNCMRINVNGGQTSTMKSSISVGNTPQKKQAFHEMLISELAAMRNKSCSLEQLPTAKSPPPTTSTPKSVASRRRYNSIDDADTEDVDADNVEDADGDVDEEDTLTYAVNKSLKENIGKEGSSSRKRCPSGCSTDSSPYGTERSQRIRTSDWIEVGDNGTAVTLTSCHISLEDSGMEDEERLDDMSSGVGDSWDSVKEAESEKRSRNGKRGNSACELPPLPKSLIGFN------------KLLCSDSGLLSDVEGNNNSSDGSRKPNDNLAVETQDTKEHATDKSLPSSPNGNTSIPPMLVAKSEAKSPSLSAKGNPQAVEAGSTLDAQIATLRKEMNGLRQLDLSLLSQLWVLNESIQEFRALIEDQENEDEDDEVEVEVGNELDEEGNSRVSSSIESVRLEG-------------------------------------------------GADGTSKHLGTIPKVITTQPKVLRDSLATASKDQKPVPRMRSAPPPPPPAVLQSLSLERKPPAPSRPTXCYLSDFLAGVRMVMCKAIVSDVPASSASASLGGDGAPLGRDAQSCLGNQTGQVLQA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. . . . : * *: *. . * : . ::. . . : : .:* :* **::* ******:***.*** * **** :: :: . . . . . . . . : . : : :.: ", "identical_positions": 26, "similar_positions": 44, "identity": "3.07%" }, { "cls_id": "homologset.agr.HGNC:16709", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q68EK2-1", "uniprot_id": "CALRL_DANRE", "id": "Q68EK2-1", "name": "Calcitonin gene-related peptide type 1 receptor", "aln": "---------------------------MTASCWTICLFLLGSVTEFIVLASPEV-------------NESQQQHPQNVYHDIGVTRNKIVTAQFECYQKIMKDNS------QDRR-GPVCNRTWDGWLCWDDTEAGITSEQHCPDYFQDFDPTEMVTKICTESGQWFLHPESNRTWTNFTRCNLHTTEGRRTAMNLFYLALIGHGLSLTSLFISLGIFFHFKSLSCQRITLHKNLFFSFVLNSIITIIWLTAVANNQELVQQNPISCKISQFIHLYIFGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPATIHAVAR----SYYYNDNCWISSNTSLLYIIHGPICAAMLVNLFFLLNIVRVLITKLKVTHQAKS-----SLYMKAVRATLILVPLLGIQYVLLPYKPS-GRVSAEIYDYIMHILMHYQGLLVATIFCFFNGEVQAVLRRHWNQYRIQ-----------------FGSTITQSDALRSASYTASSITEVQGCYSIDGHTEHLNGKNYHDFDNAIIKPENPFA-------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "I3IRX3-1", "uniprot_id": "I3IRX3_DANRE", "id": "I3IRX3-1", "name": "Calcitonin gene-related peptide type 1 receptor", "aln": "---------------------------MDRCCITSFILLLATSELFVVVLS-----------------ENSTGGTKKNAHELNFTRHKILTAQFECYQKIMKDTN------HNKTDGSMCKRTWDGWLCWEYMEPGVTSAQHCPNYFDDFDTSEVATKICTNSGHWFVHPESNRTWSNYTDCRLKSNDHKKTALNLYYLTLIGHGLSLISLFTSLGIFFYFKSLSCQRITLHKNLFFSFVLNSVITIIFFTCVANNQEVTEANPVSCKVSVFIHHYLLGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPAFIHAISR----SYYYNDNCWISSNTSLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAES-----SVYMRAVRATLILVPLLGIQYLLLPYKPD-GRLASEIFIHTTNILMHYQGLLVATIFCFFNSEVQGVLRRHWNQYRTQ-----------------FGGTFAN-TALRSASYTASSMTEVHRCYSIDGHMDSLNGKTFHNLESTILRSDNLYM-------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q63118-1", "uniprot_id": "CALRL_RAT", "id": "Q63118-1", "name": "Calcitonin gene-related peptide type 1 receptor", "aln": "--------------------------MMDKKCTLCFLFLLLLNMALIAAES-----------------EEG-----ANQTDLGVTRNKIMTAQYECYQKIMQDPI------QQGE-GLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIAR----SLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAES-----NLYMKAVRATLILVPLLGIEFVLFPWRPE-GKVAEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQ-----------------FGNGFSHSDALRSASYTVSTISDVQ-GYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM----------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R1W5-1", "uniprot_id": "CALRL_MOUSE", "id": "Q9R1W5-1", "name": "Calcitonin gene-related peptide type 1 receptor", "aln": "---------------------------MDKKHILCFLVLLPLNMALISAES-----------------EEG-----VNQTDLGVTRNKIMTAQYECYQKIMQDPI------QQAE-GLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIAR----SLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQVES-----NLYMKAVRATLILVPLLGIEFVLFPWRPE-GKVAEEVYDYVMHILMHFQGLLVATIFCFFNGEVQAILRRNWNQYKIQ-----------------FGNGFSHSDALRSASYTVSTISDMQ-GYSHDCPTEHLNGKSIQDIENVALKSENMYDLVM----------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q16602-1", "uniprot_id": "CALRL_HUMAN", "id": "Q16602-1", "name": "Calcitonin gene-related peptide type 1 receptor", "aln": "---------------------------MEKKCTLYFLVLLPFFMILVTAEL-----------------EESP----EDSIQLGVTRNKIMTAQYECYQKIMQDPI------QQAE-GVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIAR----SLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAES-----NLYMKAVRATLILVPLLGIEFVLIPWRPE-GKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQ-----------------FGNSFSNSEALRSASYTVSTISDGP-GYSHDCPSEHLNGKSIHDIENVLLKPENLYN-------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4KF12-1", "uniprot_id": "A0A0B4KF12_DROME", "id": "A0A0B4KF12-1", "name": "", "aln": "--------------------------MSDQIGNPNATFSGSGSGSGTNVAS-------------------IAESVAESGPDFDALR-AACETRLNASGQLAGSGG------PGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTCVNLEDLNWRHTVN--LISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMN-QTNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFSNRPRTNSYTATQVSFVRCGPPLPGEEKVXLKDMSAKRRASAGPQHHQPHHQSHQLSTDQQRARSQSLASSSSFLEGWRDRMPFLKRRQTIDHSRQSQPLMEEGGETVGQAKSAPGAVDRPTLMTTIAEDVAETGTAATSHAASTSDAAAAAAVGAGGATGAEEGHPNGMGTVIVRMERAGQQHMADEAL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VYH9-1", "uniprot_id": "Q9VYH9_DROME", "id": "Q9VYH9-1", "name": "", "aln": "MATTSSDSESQNVDVASQAQTQDNLRIFLKHLYAECVFRYQNVTYDTDDPSFSLGPATDYDSDLPENFSPVPRYLENAAMNEGVIDMRNVDEELAEKEELMATVVSATMATNQKENRLFCPLNFDGYLCWPRTPAGTVLSQYCPDFVEGFNRKFLAHKTCLENGSWYRHPVSNQTWSNYTNCVDYEDLEFRQFIN--ELYVKGYALSLLALLISIIIFLGFKSLRCTRIRIHVHLFASLACTCVAWILWYRLVVERSETIAENPLWCIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVVVFVKDTIVMRWFIVISWFSPIPIAIVYGLAR--HFSSPDNKHCWIT-DSLYLWIFSVPITLSLLASFIFLINVLRVIVRKLHPQSAQPAP----LAIRKAVRATIILVPLFGLQHFLLPYRPDAGTQLDHFYQMLSVVLVSLQGFVVSFLFCFANHDVTFAIRTLLNKLLPS----------------LVTPPPAGSNTGQMATTTPSRELGV----------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . . :: * .:**:*** * : **::. .*: . * * .* *: ** :*:**:*:* * : :* : *:. *: ::: *: *: **** * ** :* :** *: . :: * .. .*: * : *:: ** **:***.:** ::*.... :. : * :.* * ::.::* : * :**:. :: *: *: ::: .::** *::**:: **: . :*.***::****:*::..* *::* . : . **: *: :*** * :* :: . . . : . ", "identical_positions": 88, "similar_positions": 110, "identity": "13.35%" }, { "cls_id": "homologset.agr.HGNC:16710", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5FVH4-1", "uniprot_id": "AKTIP_RAT", "id": "Q5FVH4-1", "name": "AKT-interacting protein", "aln": "MNPLWSMSSGSVRKRAEGEEKTLAGDVKTSPPRSAP-KKQLPSIPKNALPISKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTMVVKQKLPGVYVQPSYRSALVWFGVIFIRHGLYQDGVFKFTVYIPDNYP-DGDCPRLLFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYK---------------IDTTSPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQ----------KKP--------DEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64362-1", "uniprot_id": "AKTIP_MOUSE", "id": "Q64362-1", "name": "AKT-interacting protein", "aln": "MNPLWSMSAGSVRKRAEGEEKTLAGDVKTSPPRSAP-KKQLPSIPKNALPIAKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALVWFGVIFIRHGLYQDGVFKFTVYIPDNYP-DGDCPRLLFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYK---------------IDTTSPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQ----------KKP--------DEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H8T0-1", "uniprot_id": "AKTIP_HUMAN", "id": "Q9H8T0-1", "name": "AKT-interacting protein", "aln": "MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAP-KKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYP-DGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYK---------------IDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQ----------KKP--------EEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZYX1-1", "uniprot_id": "AKTIP_DANRE", "id": "Q7ZYX1-1", "name": "AKT-interacting protein", "aln": "MNPFWSMSTNAGRKRSDGEEQSGSGEQRASPARPPFGKKQLPSIPKNAVPITKAASPASSTQSANGTHASYGPFYLEYSLLAEFTLVIKQKLPGIYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYP-DGDCPKVVFDTPVFHPLVDPVSGELDVRRAFTKWRRNHNHIWQVLMYARTIFYK---------------INTMEPLNPEAAVLYDKDIQLFKSKVVDSVKLCNSHLFDQPKIDDPYAISFSPWNPAVHEEAKEKMFAH----------KRR--------PEDFNKGLPVSGLSWVKPGSTQPFSKEDNPLQT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1ZBR5-1", "uniprot_id": "AKTP2_DROME", "id": "A1ZBR5-1", "name": "Protein crossbronx-like", "aln": "---------------------------------------------------------MWYSTVRNPS---IALIKQGYHILAEYNLVK-EELKNIYAIPSYACGLHWFGVIFVHSGIYAGSVFRFSILLPENFPADISLPTVVFSTEVLHPHICPQNKTLDLAHFLNEWRKDEHHIWHVLRYIQAIFADPEGSICTGQSSSGDLVIMDEVRNMNALNMLAKSRPEYIKRVQEQAILSRNLIYDRPPTEDPHYIIVEPYCAERHLKFMDQLKSPCWKEATSMDCSQPSEYLGHIDSSRQLDEEEANQVEKLHRGRIPEHQREESEVSL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q7K4V4-1", "uniprot_id": "AKTP1_DROME", "id": "Q7K4V4-1", "name": "Protein pendolino", "aln": "-------------------------------------------------------MTLDLDAHKKDDKLLITTIQQEYKILAEYKMIESEKLSGIYVIPSYANSLQWFGVFFGRQGLYAESVFRFTILLPDRFPDDKSLPSIIFQQDVIHPHVCPYTHSLDVSHAFPEWRCGEDHLWQLLKYLQVIFSDPLDSIRG--------IEVDKLKNSEAAELLMNNKEEYVARVQENIKESKEHIFDTPPTEDPHYIVFEKFQQDVHGPVLERIK------AGRSKLTEP--------SAQQANGGHATGLSWVKEGEFKPLSIE------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * :***:.:: ::* .:*. *** .* ****:* : *:* .**:*:: :*:.:* * . * ::*. *:** : * . **: : : :** ...*:*::* * : :* . : . * :* : :. : :* :. . ::* * :**: * .. : * ::: .. . . :. :: * . * ", "identical_positions": 49, "similar_positions": 74, "identity": "14.98%" }, { "cls_id": "homologset.agr.HGNC:16711", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EPW9-1", "uniprot_id": "TLR6_MOUSE", "id": "Q9EPW9-1", "name": "Toll-like receptor 6", "aln": "------------------------------------------------------------------------------------------------------------MSQDR--KPIVGSFHFVCALALIVGS-------MTPFSNELESMVD--YSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELR------VLRLSHNRIR----SLDFHVFLFNQDLEYLDVSHNRLQNISCCPMA-SLRHLDLSFNDF--------DVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAH------LHLSCILLDLVSYHIKGGETE--SLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGH----------LQLSNIKLNDENCQRLMTFLSELTRGP-----------------------TLLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYN------LTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIH-MVCPPSP-SSFTFLNFTQN-VFTDSVFQGCST----LKRLQTLILQRNGLKNFFKVALMT-------------KNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFR----CLP--PKVKVLDLHNNRIMSIPKDVT--------------------HLQALQELNVASN-----------SLTDLPGCGAFSSLSVLVIDHNSVSHPSE-----DFFQ-SCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDS--------YRCDYPESSKGTALRDFHMSPLSCDT------------------VLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIP-LEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYHKLRALMAQRTYLEWPTEK------------------GKRGLFWANLRASFIMKLALVNEDDVKT-------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A096MKA9-1", "uniprot_id": "A0A096MKA9_RAT", "id": "A0A096MKA9-1", "name": "Toll-like receptor", "aln": "-------------------------------------------------------------------------------------------------MVKSLWDSLCNMSQDR--EPIVESFHFVCTLALIVGS-------MTQFSDEFESVVD--YSNKNLTHVPKDLSPSTKSLSLSQNSISDLQMSDISFLSELR------VLRLSHNRIR----RLDFGVFLLNRDLEYLDVSHNQLQNISCCPMV-NLKHLDLSFNDF--------EVLPVYKEFGNLMKLSFLGLSAAKFRQLDLLPISH------LHLSCVLLDLVNYQIKDGETE--SLQVPNTNVLHLVFHPNSLFSVQVNISVNALGC----------LQLSNIKLNDKNCQSLIIFLSELTRGP-----------------------TLLNLTLQHIETNWKCFVRLLQFLWPRPVEYLNIYN------LTITESISRETFIYVETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIH-MVCPEFP-STFAFLNFTQN-VFTDSIFQGCST----LKRLETLILQRNGLKNLFKVALMT-------------KTMSSLETLDVSLNSLNSHVYDRTCAWAESIRVLNLSSNVLSDSVFR----CLP--PKVKVLDLHNNRIVSIPKDVT--------------------HLQALQELNVASN-----------FLTDLPGCGAFSSLSVLVIDHNSVSHPSS-----DFFQ-SCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDS--------YRCDYPDSIKGTPLQDFHMSPLSCDT------------------ILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRHRARNIP-LEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKD--DIRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEKENSYQ---------LSVGGSRCLNFLLLCRTGRLSCEMFRKTQHAVTHIHSSVFTKSP-------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y2C9-1", "uniprot_id": "TLR6_HUMAN", "id": "Q9Y2C9-1", "name": "Toll-like receptor 6", "aln": "------------------------------------------------------------------------------------------------------------MTKDK--EPIVKSFHFVCLMIIIVGT-------RIQFSDGNEFAVD--KSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELT------VLRLSHNRIQ----LLDLSVFKFNQDLEYLDLSHNQLQKISCHPIV-SFRHLDLSFNDF--------KALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAH------LHLSYILLDLRNYYIKENETE--SLQILNAKTLHLVFHPTSLFAIQVNISVNTLGC----------LQLTNIKLNDDNCQVFIKFLSELTRGS-----------------------TLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYN------LTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIH-MLCPHAP-STFKFLNFTQN-VFTDSIFEKCST----LVKLETLILQKNGLKDLFKVGLMT-------------KDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFR----CLP--PRIKVLDLHSNKIKSVPKQVV--------------------KLEALQELNVAFN-----------SLTDLPGCGSFSSLSVLIIDHNSVSHPSA-----DFFQ-SCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDS--------YKCDYPESYRGSPLKDFHMSELSCNI------------------TLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIP-LEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKE--DIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEK------------------SKRGLFWANIRAAFNMKLTLVTENNDVKS------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VPH1-1", "uniprot_id": "Q9VPH1_DROME", "id": "Q9VPH1-1", "name": "", "aln": "---------------------------------------------------------------------------------------------MCPKYIWDVIVLVCLFLGNV--REAYTEFSIQDGLIIEPDS-------ATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFR-TLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHN------TTDLYDRECYLYFNNNTNMGQ--SITTGRNYTNFIKVLKDRFDQHGSSSQSIAWAT----------FPKMPRLVELDISNCSIEYVSKEAFR------------------------NVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSF------TNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLG-DKLKFLS-LCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNI---KDLEWSKSLKNLQVLGLAGNNIN-ALTPAMFQSLESLEILDLSSNHVGNWYRS----AFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYI-----PWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETG-DVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRP---KTLQYLMDVKTYIKWPTAK------------------EDRKLFWKRLKRSLEVIGINSREISV---------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P08953-1", "uniprot_id": "TOLL_DROME", "id": "P08953-1", "name": "Protein toll", "aln": "MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLEN----LESIEFGSNKLR----QMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNG-------IEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQ--PELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLS-QNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPN------------------LHKNMQLMELHLENN------TLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTN-LTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICP---------------AEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIG--DVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJX9-1", "uniprot_id": "Q9VJX9_DROME", "id": "Q9VJX9-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------MLTYLPVVWLFFALLVLRSATGQIIPLPTFCLGLSP---------QCTCAAEGNVVRFHCPDEYAMLLEVSEPGASLYMSYYASTELQWLPRFNISSLVK-------IEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPEN----------ITTWHFGSVPGLKKFKFFSHVPELQESIFHGFDT----LRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLAL-------------------IHPFHERDKQLQPHFFGS------------------------MTNLEEVRLAS-ATSSVNRSMFKGTNKLQLIKMNG----------NDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVS----LNYIEMVNTQFYGAT-----------------------LLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVG-------------------SLIVDCRGTSLEELPDLPR--------------------TTLLSTVLKVGNN-----SLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCP--------------------SYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSEEELDKDKTYDAFISYSHKDEELIS-KLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEH--MNGIDSELRAYLKLNTYLKWGDPLFWS------------------KLYYAMPHNRRVLKGQKKHAGPLI--------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : . . .. : . : :. : : . :..: . : *. . . : . . . : : . : . . : : : *. : : * . :. :.: : .: : : : . : . : . : :: : : : : : . : :: * . ::: :. : :. : * : * .: : . :: .::: :. : : . : : . : : : .. .: : . :. *:**..:* : *:* :* . :*:*:*:: * * ::*: : * ::::* :*: * *.: *: * : :. ..:*::: : *: : .**::* * ", "identical_positions": 32, "similar_positions": 150, "identity": "2.77%" }, { "cls_id": "homologset.agr.HGNC:16712", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z902-1", "uniprot_id": "FBXW7_RAT", "id": "D3Z902-1", "name": "F-box/WD repeat-containing protein 7", "aln": "----------------------------------------------------------------------------------------------------------------------------MNQELLSVGS---------KRRRTGGSLRGNASS---SQVDEEQMNRVVEEDPQQQPRHQEEEHTARNGELVGADPRP-GAQNDSQQG--QVEENNNRFVS---VDEDS--------SGNQ---------------EEQEEDEE--------------------------------------------------------HAGEQEEEEEE--EEEEEEEEEMDQESDDFDQSDDSSREDEHT------------------------------------------------HNSNVTNCTSVVDLPINQLSS---PFYTKT----TKMKRKLDHGS-----------------------------------------------------------------------EVRSFSLGKKPCKVSDYTSTTGLVPCSATPT---------------------------------------------------TFGDLRAANGQG--------------------------------------------------------------------------------------------------------------------------QQRRR-----------------------------------------------------------------ITSVQP------------------PTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW-RILAEDNLLWREKCKEEGIDEPLHIKRR--KIIKPG---FIHSPWKSAYIRQHRIDTNWRRGELRSPK-VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR----VVSGSRDATLRVWDIETGQ-----------------------CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGN--------------------CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR------------------IRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VBV4-2", "uniprot_id": "FBXW7_MOUSE", "id": "Q8VBV4-2", "name": "F-box/WD repeat-containing protein 7", "aln": "----------------------------------------------------------------------------------------------------------------------------MNQELLSVGS---------KRRRTGGSLRGNASS---SQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRP-GDQNDTQQG--QVEENNNRFIS---VDEDS--------SGNQ---------------EEQEEDEE--------------------------------------------------------HAGEQEEEEEE--EEEEEE---MDQESDDFDPSDDSSREDEHT------------------------------------------------HNSNVTNCSSVSDLPAHQLSS---PFYTKT----TKMKRKLDHGS-----------------------------------------------------------------------EVRSFSLGKKPCKVSDYTSTTGLVPCSATPT---------------------------------------------------TFGDLRAANGQG--------------------------------------------------------------------------------------------------------------------------QQRRR-----------------------------------------------------------------ITSVQP------------------PTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW-RILAEDNLLWREKCKEEGIDEPLHIKRR--KIIKPG---FIHSPWKSAYIRQHRIDTNWRRGELKSPK-VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR----VVSGSRDATLRVWDIETGQ-----------------------CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGN--------------------CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR------------------IRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969H0-1", "uniprot_id": "FBXW7_HUMAN", "id": "Q969H0-1", "name": "F-box/WD repeat-containing protein 7", "aln": "----------------------------------------------------------------------------------------------------------------------------MNQELLSVGS---------KRRRTGGSLRGNPSS---SQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRP-GGQNDSQQG--QLEENNNRFIS---VDEDS--------SGNQ---------------EEQEEDEE--------------------------------------------------------HAGEQDEEDEE--EEE------MDQESDDFDQSDDSSREDEHT------------------------------------------------HTNSVTNSSSIVDLPVHQLSS---PFYTKT----TKMKRKLDHGS-----------------------------------------------------------------------EVRSFSLGKKPCKVSEYTSTTGLVPCSATPT---------------------------------------------------TFGDLRAANGQG--------------------------------------------------------------------------------------------------------------------------QQRRR-----------------------------------------------------------------ITSVQP------------------PTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW-RILAEDNLLWREKCKEEGIDEPLHIKRR--KVIKPG---FIHSPWKSAYIRQHRIDTNWRRGELKSPK-VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR----VVSGSRDATLRVWDIETGQ-----------------------CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGN--------------------CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR------------------IRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PIU0-1", "uniprot_id": "A0A8M9PIU0_DANRE", "id": "A0A8M9PIU0-1", "name": "F-box/WD repeat-containing protein 7", "aln": "MSRSMCGCGCSFISSLMKRLGRSACCSD-----------------------------------LLSCSHTSEHLQRLATGCPSQH---------------KNAKSLSSSDSLAKVQEVASWLLEMNQDLLSGGSGSR--AAQQQRPRPGTAGAGNSISGRTPQPQPEHPDQVLEEPEQEEAQQQRREPAEEEDEGGPERQQD-GDEQPWPSGGEPMEDGEGRRSE---VNGDE--------KGAQWLWEQEQRRRRRPHREEEEENEEEEEN-------------------------------------------NNSGREGQVGAGLRSEEDDDRPEEDNEGEEEMDQDSDEFEHSEESEREEEEEDGEEE-------------------------------------EGEEGLHSPSLRTSVSDHNDNTDQSSGRQRQSLRSP----NRMKRKLDHGP-----------------------------------------------------------------------EVRSFTTGKKPCP-----SPTG----QQYPA---------------------------------------------------TFGDLRAVNGQV--------------------------------------------------------------------------------------------------------------------------PQRRR-----------------------------------------------------------------ITSIQP------------------PTGLQEWLRTFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPRELALHVLSFLEPKDLLQAAQTCRYW-RILAEDNLLWKEKCKEEGIDEPLHIKRR--KVIKPG---FTHSPWKSAYIRQHRIDTNWRRGDLKSPKVVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR----VVSGSRDATLRVWDIETGQ-----------------------CLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGN--------------------CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSAVTCLQFNKNFVITSSDDGTVKLWDLRTGEFIRNLVTLESGGSGGVVWR------------------IRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VZF4-1", "uniprot_id": "FBXW7_DROME", "id": "Q9VZF4-1", "name": "F-box/WD repeat-containing protein 7", "aln": "MERGCPAASSESVTSAGERTQSAVTSSTSTWVKSQASTSRKTEASEESGLGAVDAEVGAGREAFVSMSTLREDVEDVCVSSNSQHGFAVVLDDESSTFEISSSNSLPTSAGAASTVGVVAVDDSSSTDTLNGGHPDLGHPASSEHSRQGFFNEDNEDPPVVCLINDDDDDEEPEPEEDDEEELIEDEDEDAVDIVTGAISCPNTSQLALADGTIMAADGSKIFLETPVVEEAQPHPGQVVTTGSQSELTGKPKRLSDEFLLGEEDQAENLALGRCIKSEPVNPVDDNPSEGDDGATCFSLHDRLMSVRLKQMSLTANTVSNPSPAASANAAAPEEASTSNSSSTSSSALSRADIESMDLIERRDFETEQRLTGGIILRTSSMVSQNKLNLSLIKSMAGGSKAANGSGTANSDDWPSSSNGRTVSSDSKYTYKDLSTTPTSSRKYTNSRLSKSTAKLNLGSSLGASSCSQHRSGSSSTSKSMESSTSCTGAARTDVYTNTNSNDYPSLAPTTSGSSTSGGSCQQDQEENVSASVSYSSVGSQTSQESGCSRTTAINPTAACSTGSACLGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSW-RFLCDDNLLWKEKCRKAQILAEPRSDRP--KRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPK-VLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGN-IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSK----VVSGSRDATLRVWDIEQGS-----------------------CLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDG--LHVVSGSLDTSIRVWDVETGN--------------------CKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWR------------------IRANDTKLICAVGSRNGTEETKLMVLDFDVEGACVKCS-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P07834-1", "uniprot_id": "CDC4_YEAST", "id": "P07834-1", "name": "Cell division control protein 4", "aln": "-------------------------------------------------------------------------------------------------------------------MGSFPLAEFPLRDIPVPYS----------YRVSGGIASSGSVTALVTAAGTHRNSSTAKTVETEDGEEDIDEYQRKRAAGSGESTPERSDFKR------VKHDNHKTLHP---VNLQN--------TG--------------------------------------------------------------------------------AASVDNDGLHNLTDISNDAEKLLMSVDDGSAAPSTLSVNMGVAS------------------------------------------------HNVAAPTTVNAATITGSDVSN-----NVNS----ATINNPMEEGA------------------------------------------------------------------------LPLSPTASSPGTTTPLAKTTKTINNNNNIA------------------------------------------------------DLIES--KD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIISP-----------------EYLSDEIFSAINNNLPHAYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQDRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQFEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGGILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSVPDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDAN--DYSRKFSYHHTNLSAITTFYVSDNILVSGSEN-QFNIYNLRSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEILDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * .. . . : :: . * :. *: . .* : . : .: . . . . . . : * . . :: *. : . .... .* : : : * : : : . * .*: : ::: .: :*: :::**:*: ** *::* ::.:*: :*::.: ..: * ::: ... **:: . : . * : . : :::.: * ** . : .*:** ******* .* :::*:**: ::*:.::. * * * ** ****: : . *::*******::**: ..* * *.: **.*****:.: : :*:**** **:**.: . : ** **:*:** *. .*. :***:** : :*. **: *.***:*:** :* : :*.*:**:**:**:*. . :** ** :*.. :.* :::***. **.::: ** . : :.:. .: **:* : ....::::.*:: .:::::::*.::: : ::. .* :: : ..:. : *.. .:..:.* :. .: ", "identical_positions": 135, "similar_positions": 231, "identity": "9.65%" }, { "cls_id": "homologset.agr.HGNC:16713", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R0U0-1", "uniprot_id": "SRS10_MOUSE", "id": "Q9R0U0-1", "name": "Serine/arginine-rich splicing factor 10", "aln": "MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6A795-1", "uniprot_id": "A0A8I6A795_RAT", "id": "A0A8I6A795-1", "name": "Serine/arginine-rich splicing factor 10", "aln": "MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75494-1", "uniprot_id": "SRS10_HUMAN", "id": "O75494-1", "name": "Serine/arginine-rich splicing factor 10", "aln": "MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**********************************************************************************************************************************************************************************************************************************************************************", "identical_positions": 262, "similar_positions": 0, "identity": "100.0%" }, { "cls_id": "homologset.agr.HGNC:16714", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BG99-1", "uniprot_id": "PKNX2_MOUSE", "id": "Q8BG99-1", "name": "Homeobox protein PKNOX2", "aln": "MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTPGTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEEL-EEEADELQTTNVSDLGLEHSDSLE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JYQ2-1", "uniprot_id": "A0A0G2JYQ2_RAT", "id": "A0A0G2JYQ2-1", "name": "", "aln": "MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHIAAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTPGTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEELEEEEADELQTTNVSDLGLEHSDSLE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96KN3-1", "uniprot_id": "PKNX2_HUMAN", "id": "Q96KN3-1", "name": "Homeobox protein PKNOX2", "aln": "MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQAMMAAHDDSLDGTEEEDEDEMEEEEEE--EL-EEEVDELQTTNVSDLGLEHSDSLE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P53147-1", "uniprot_id": "TOS8_YEAST", "id": "P53147-1", "name": "Homeobox protein TOS8", "aln": "-------------MGTSIVNLN--------QKIELPPIQVLFESLNRENETKPHFEERRLYQPNPSFVPRTNIAVGSPVNPVP----------------VSSPVFFIGPS--PQRSIQNHNAIMTQN-------------IRQYPVIYNNNREVISTGERNYIITVG-------------GPPVTSSQP----------------------EYEHISTPNFYQEQRLAQPHPVNESMMIG-GYTNPQPISISRGKMLSGNISTNSVRGSNNGYSAKEK------KHKAHGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRKIFSGQNDAN-----NFRRKFSSSTNLAKF----------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.*. * ** :. : . : . :*:..: . .. . *: *: ::*. * :. . ::. *:*:.::::: :* : : :: .*: . ..** : * * :..** : : * .* :* .**..:: * . :* .: *:*:::: *. .::: .*. . . . .:*::.**. *** :..*:..**.:*: :**** :***:: *:*.** **:.********* : . : :* : :: *. :* ", "identical_positions": 66, "similar_positions": 110, "identity": "13.89%" }, { "cls_id": "homologset.agr.HGNC:16715", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZZZ0-1", "uniprot_id": "A0A8I5ZZZ0_RAT", "id": "A0A8I5ZZZ0-1", "name": "ATP-dependent RNA helicase", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------MRRQTEATKRKHQVSSDAPPAKRRNEISSLSAKKASNKETQR---AFKGSAHKTFPPKKHLDTIGNERQEEK--PCVKTSSLFKNNPE---------------------------------------------------------------------IPELHRTVVKQAREQVFSPEAFQELDLHPHLISTINTVLKMSSMTSVQKQSIPVLLE---GRDALVRSQTGSGKTLAYCIPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNIHFNR---VRWLVVDEADRILDLGFEKDVTVILNAVN----------AECQKRQNVLLSATLTEGVTRLADISLHNPVSISVLDKSWDQPNPKE--------------------VASIQLDSFAIPESLDQYVVLVPSKLRLVCLAAFILKKCKFE-------KDQKMIVFFSSCELVEFHYNLFLHTLLC---------HSGTPASETLPSASWPLK----FLRLHGNMKQEERTSVFHEFS------HSGTGVLLCTDVASRGLDLPQVTWIVQYSAPSAPAEYIHRIGRTARIGCHGSSLLILAP-SEAEYVNSLA-SHKINVSEIKLEGILAVLAKDDCFKRR---------QRGAQRSHATGPQEIRERATVLQTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPKELKSIFHVRSLHLGHVAKSFGLRDAPRNLG-------VSAVR--KASFKRPDPRRKTQRKHHLVPAEVLHSEHSSGLEGNGTKGRKQG--------------LRVAP------------SKPGLRR----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NZQ2-1", "uniprot_id": "DDX31_MOUSE", "id": "Q6NZQ2-1", "name": "ATP-dependent DNA helicase DDX31", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------MKRQAEATKRKHQVSSDAPPAKRRSEISSVLAKKASDKETQR---TFKGSTHKTFPPKKYLDSIGNGRQEEK--PCIKTSSLFKNNPE---------------------------------------------------------------------IPELHSTVVKQAREQVFSPEAFQELDLHPHLISTINTVLKMSSMTSVQKQSIPVLLE---GRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFNR---IRWLIVDEADRILDLGFEKDITVILNAVN----------AECQKRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKE--------------------VASIQLNSFAIPESLDQHVVLVPSKLRLVCLAAFILQKCKFE-------KNQKMIVFFSSCELVEFHYSLFLHTLLC---------HSGTPTSEHLPSASWPLK----FLRLHGNMEQEERTSVFHEFS------HSETGVLLCTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAP-SEAEYVNSLA-SHKINVGEIKMEDILAVLAKDDCFKRR---------QRGAQKSRASGPQEIRERATVLQTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPKELKSIFHVRALHLGHVAKSFGLRDAPRNLS-------VSAVK--KASLKRPHPRRKTQRKQHLVPAEVLHSEHSSGLEGGATKCRKQGK----------QQGLQVAP------------SKPGPWRE---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H8H2-1", "uniprot_id": "DDX31_HUMAN", "id": "Q9H8H2-1", "name": "ATP-dependent DNA helicase DDX31", "aln": "-----------------------MAPDLASQRHSESFPSVNSRPNVILPGREGRREGLPPGGGTRGSLVPTRPVPPSPAPLGTSPYSWSRSGPGRGGGAGSSRVPRGVPGPAVCAPGSLLHHASPTQTMAAADGSLFDNPRTFSRRPPAQASRQAKATKRKYQASSEAPPAKRRNETSFLPAKKTSVKETQR---TFKGNAQKMFSPKKHSVSTSDRNQEER--QCIKTSSLFKNNPD---------------------------------------------------------------------IPELHRPVVKQVQEKVFTSAAFHELGLHPHLISTINTVLKMSSMTSVQKQSIPVLLE---GRDALVRSQTGSGKTLAYCIPVVQSLQAMESKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNIHFSR---LRWLVFDEADRILDLGFEKDITVILNAVN----------AECQKRQNVLLSATLTEGVTRLADISLHDPVSISVLDKSHDQLNPKDK-----------AVQEVCPPPAGDKLDSFAIPESLKQHVTVVPSKLRLVCLAAFILQKCKFE-------EDQKMVVFFSSCELVEFHYSLFLQTLLS---------SSGAPASGQLPSASMRLK----FLRLHGGMEQEERTAVFQEFS------HSRRGVLLCTDVAARGLDLPQVTWIVQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAP-SEAEYVNSLA-SHKINVSEIKMEDILCVLTRDDCFKGK---------RWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVSWAKKALQSFIQAYATYPRELKHIFHVRSLHLGHVAKSFGLRDAPRNLS-------ALTRKKRKAHVKRPDLHKKTQSKHSLA--EILRSEYSSGMEADIAKVKKQNAPGEPGGRPL-QHSLQPTPCFGRGKTLKWRKTQKGVQRDSKTSQKV--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6R7-1", "uniprot_id": "A0ACD6B6R7_DANRE", "id": "A0ACD6B6R7-1", "name": "ATP-dependent RNA helicase", "aln": "-------------------------------------------------------------------------------------------------MAEDTLMLN-------ISSGSVQFNRKTNQKHLSSSEKWAQKKRVAKRKAAVEPQESSASKQRKINQTGQQHAQKQTLQTPRSPSQRSNNRDTEENPVQRENSEAKSPSKVKTFPKKAPTEHEDHGRPFIKTSSLFRNNPE---------------------------------------------------------------------IPDVLSPAVNQVKEKVFTSNTFEELNLHPHLVATLHKVLNVSSMTSVQKQTIPVLMS---GKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSA---VRWLILDEADRILDLGFEKDLTVILNALN----------TAGPDRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSEETVEACP------------------QAAPQALSDSYAVPERLQQHVVVVPSKLHLVCLAAFILAKCKFE-------QRQKLVIFISSCEAVEFLLNLFTAVLCE---------IPSNTSSK----STSCLN----FYRLHGNMRQEERTEVFQEFS------QCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP-SETAFVDVLA-NHNISLSEMKMVDILSTLMKDERFKGRG--------KWDSKRSADAFEQEVRERATLLQTDFENYVHASNESLQTAKSALQCFLRAYTTYPSSLKHIFHIRMLHLGHAAKSFGLRDAPQGLASSISTNPANSKHSKKAKDKAKSPPKKLTAKQRVS--NLMRSEYDSGMDGQSKAKKKRK-------------------------------NKKGQAEESTDA-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q86B47-1", "uniprot_id": "Y8611_DROME", "id": "Q86B47-1", "name": "Probable ATP-dependent RNA helicase CG8611", "aln": "MVENISLNVTVKSSARKNQQQSPALSVKKRAQKSQDFDFQFNVDKPKVKAIVVRRRAPPSKVEPTNSSVPNTTKSPTPSVSSSKSAISTLSASPKANASNDDLMFNVSPTKPPVKSVLGDDFMLNVTTKPVVAQKAKPKITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRREEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQSPGQEKEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQ---GKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTK---LQFLILDEADRLLELGYERDVKQLVEAIDKQRAECE--DKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASP------KQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLR----FFKLHGSMTQTERQGVFRGFR------DCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTP-SEAQFVRHLE-KKRIRIQQGDMYAYLQTLLPKD-----------------------DEARTVQEAASNLQHKFQTLLEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKAAPPTNRLTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPKGGFIGGGVGRSSFMKSLGKSRALNMSEFDSGLPPEGAAKRRKQA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36120-1", "uniprot_id": "DBP7_YEAST", "id": "P36120-1", "name": "ATP-dependent RNA helicase DBP7", "aln": "------------------------------------------------------------------------------------------------MSDEDSMLLN------------FTTNEDTAGSSYKQAAKVTGGRWKDRRRMKMKLEGKTVSRKRKANTTGDEGIIPGRGENSIKKLHKESSYSSEEQEKYKGRNAHNTQGRTLPADSQFVSSLFTSNREITTAVNTNIHDEN----------------------------------------------------------------------------VAINPSNAPLKGDQFASLGVSSLLVSHLEQKMRIKKPTSIQKQAIPQIIGNAGKNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSQSLRYIVLDEGDKLMELGFDETISEIIKIVHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISNGTKKDSD-------------------------------IVTVAPDQLLQRITIVPPKLRLVTLAATLNNITKDFIASGQQSKTLRTIVFVSCSDSVEFHYDAFSGSDGHHKNLTGDSVRLLTKGNTMFPCFSDSRDPDVVIYKLHGSLSQQMRTSTLQHFARDNEATKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFLLPGEEEKYMDYIQPYHPMGWELLKFDKEILMPAFKDVNVNRNDKFIRKDEKSSKNKDVGDKEYEWDTNATTWHLNIERRVVGDSAFKNLAVKGFISHVRAYATHISQEKKFFNVKFLHLGHLAKSFGLRERPKAMG----------LQSSKDGNSEKKPTKENSKNKMFRMARMAEKQIASEFNY---------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. : : : : : . .. . .. . .. : :. : *.: . : :. : : . **:*:::** :: .* .:::********:* :*::. : .::.*..* *:*:.*****. * :. ..*: ::** *:*** :*:******** *.:*.****::**: * : :::::.**.*::::**::. :. ::: :. . .:* ***:*. : :* .::::: : . *: * .:**.**:** *:: : . : : ::*.* : *:* . : . : :***.: * * .:: * . :::.***..**:*:*.: ::: .* : :.:**:***** * :* ::*:* * .* :: : : : .: : .: *: : :: : . . : ..: . :: *:*. . * :*::: *:** ****.*:: * :. . : . : . : ", "identical_positions": 117, "similar_positions": 203, "identity": "11.43%" }, { "cls_id": "homologset.agr.HGNC:16716", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BJS0-1", "uniprot_id": "DHX30_RAT", "id": "Q5BJS0-1", "name": "ATP-dependent RNA helicase DHX30", "aln": "-----------------------MFTLDSFRKDR-TQHRQRQCKLPPPRLPPMCVNP---APGGTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIRPAGTGGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSS--WISPELRLQSDDILPLGKDSGP---LSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPAR-GGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAK-------LGKHQY--PHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPLSVQQEHGQLLALLAELLR-----------GPCGSFDVRKTADD--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PU8-1", "uniprot_id": "DHX30_MOUSE", "id": "Q99PU8-1", "name": "ATP-dependent RNA helicase DHX30", "aln": "MVTPVCNSSTWQPKDSSFLSWPEMFSLDSFRKDR-TQHRQRQCKLPPPRLPPMCVNP---APGGTITRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIRPGGPAGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSS--WISPELRLQSDDILPLGKDSGP---LSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPAR-GGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAK-------LGKHQY--PHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLREFRRALGRMVERSLRSELAALPLSVQQEHGQLLALLAELLR-----------GPCGSFDMRKTADD--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7L2E3-1", "uniprot_id": "DHX30_HUMAN", "id": "Q7L2E3-1", "name": "ATP-dependent RNA helicase DHX30", "aln": "-----------------------MFSLDSFRKDR-AQHRQRQCKLPPPRLPPMCVNP---TPGGTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPESIRPGGPGGLSRSLGREEEEDEEEELEEGTIDVTDFLSMTQQDSHAPLRDSRGSSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESS--WIAPELRLQSDDILPLGKDSGP---LSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSR-GGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAK-------LGKHQY--LHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLKELRRALGRMVERSLRSELAALPPSVQEEHGQLLALLAELLR-----------GPCGSFDVRKTADD--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7TE51-1", "uniprot_id": "A0A8N7TE51_DANRE", "id": "A0A8N7TE51-1", "name": "ATP-dependent RNA helicase DHX30", "aln": "-----------MAMSSALTPLRALLSLRSKTLEINKDIRSRWAFIRQYRSKPDVVHTRRHSPPETINKAHPDYL----HAKNLLYNTLSRSVGLSNVSQYLKFSCTDG-EVKRATVTLLWPVRIETEGFGSRKQEAERNAAAAALQKLCELGVYAPGK----------------------RRQE---------------------AGMLRMKDRQTSLCDNE--EENHLQSLPIQKKTQKDRAHGLVE---------EDSRLSEALAIFPRPRTLLGSVIQVATSSCRVRDLLQYKTSGGKVKVCELNVLWPTPMTFTASGRRRLEAEANAAALACLKLKELNLLDEQNKPLTHARYHQDQVREAGERHRQPCRMQIPEQLELRIQQYLSQYPVEAEVQKLWDEEEHQSSSISTAADDYDEDEFITDAITSKPYRALEPKEAEHLSQRLLSMWKRVGPAR--GAELPVDAHKESILEAVRSSQVVVISGETGCGKTTRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQRVAHEIGPALQHCVGYQVRLESRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDVQTDLLLHLLRCVLSLRPELKVLLMSASGDSQRLAQYFGGCPVLRVPGFMHPVRARFLEDMQLDSRRPLLDMGSTQWSAEVRGRMGKEENNVTPDLDLVADVIDHIHRTGEPGAVLCFLPGWQEIKAVQQQLEEKQAYRSGSQIILPLHSSMAVSEQQVVFQRPPAGQRKIVLATNIAETSITIDDIVHVVDAGVQKEQNYDPRTKVSALNTVWISQANVTQRRGRAGRCQPGHSYHLFPRKQLERMEPFPVPEILRTPLESVVMQAKIHCPESKAEDFLSQVLDSPDTQAVRTAVKNLMDIGVLDASEDLTPLGHHVSCMSCDPRLGKVLVFSALFSCVQPVLSVVACLTRDPFYNSLQNRTLVSKAKAELSGSSGSDYLVFSRVVQSWREQH---SRDSRQDYLDKHTLSGASLRFIHGLMQQFSDNLCEAGLVDHSAECLRLSSPVNQQSKEEQLITAVLLAGLYPNLIQVKKGVVTKSGRFRAENVSFRTESGPVLLHRSSVNRDKQHLWSRWLTFFSAVKSSGQVFIRDSTVVHPLALLLLTDCDLSERVVGDRVEVALPGPALIRWEFSPAVWELLWDLRASIQAMIYRKLR-QSECKSSSEQRKDSELIDLLVDLLNNTDPDVSRDQEDALNSSNTENAEADSC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :::* * : : *.* . : * * *:. :* **.:* * * :.**** ..:.*::*:*:..: * : *:* : *:.*: : ** :*.**:**:* :***:***** * : *: .* : * * .*: * .*: . ::* **. :: : . **:* * : :*. .**: ** *:.**..***:****. .::*:*::* * *.*:. *.:*** ****.*.***: *** :****** ***.*.*:*.:*:***** *: .:** ** :*:** :*:** : :*: :*.:***::. : * . **..* . ..* . ::*.**.*** .* * :*** **.:*:* ** ..:****.*:::**.*:.. ******:**********::*** * .*.**.***::***************:**:**:*:: **:******:** * ****** *:*:**:****** ***:*************:**:** **: : *.* *:::****:**.:*:::*******::*****:**: ::***: . :*. *: * * :.*:: : *****:*:: **. ****.:***********.***:*:* . :... :***:**.:.: :*:.:**:** * ***************::*******:*::**:.** :****.*:***:*:*** **********.*.:******.:**:* ** **********.:*:***** **..* :***:.:***: :** ** * :***** * **.**:::: :* ****.*.:*::*:* *::*:* **:******* .*****: *.*.** ** .****:*.* *.* .*.* .* **::**::: * ..********::***:*: ** **.:.::* *: *: *:**:*:..**:**********::* **:.*:*:.:.*::**:** :***:*::**: :* *****:* ****.*.**:***: *****:***** *: * * *. ::*... *:* * .. . .** ::* :: *: *.** : . . * *.:..:*: **.:**. .. .* : .:: * ", "identical_positions": 573, "similar_positions": 348, "identity": "45.88%" }, { "cls_id": "homologset.agr.HGNC:16717", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZGJ0-1", "uniprot_id": "D3ZGJ0_RAT", "id": "D3ZGJ0-1", "name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "aln": "-----------MSSLREEMDEEELEHPNASPEKRYFPESLDSSDGDEEGVLAC-------------EDLELNPFDGLPYSSRYYKLLKEREELPIWKEKYSFMESLLQNQVVLVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIINCSPFLISRLSSYYGNVPLLEVRN-KHPVEVVYLSGAQKDPFESVVRLIFEIHRSGEQGDVVVFLACEQDIEKTYEIVCQEGSNLN--PDVGELVVIPLYPKEKCSLFRPVDE-TEKRCQASQRRVVLTTSCGESLIWS-HTVRFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEANLTSMVLFMKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINIYNAYQDTVLNSANEHCVETWCHNCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSQENGLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSSYAITKK---MPEWVLFHQFSISENNYIRVTSAVSPELFMQLVPQYY-FSNLPPSESKDILQQAS--GHL-PTTAMDKDQDVCDKCPDATEQRCTVQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BZS9-1", "uniprot_id": "DHX32_MOUSE", "id": "Q8BZS9-1", "name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "aln": "------------------MDEEELDHPNASPEKRYFPESLDSSDGDEEGVLAC-------------EDLELNPFDGLPYSSRYYKLLKEREELPIWKEKYSFMESLLQNQVVVVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVICTQAHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNCSPLLTSKLSSYYGDVPVIEVRN-KHPVEVVYLSGAQKDSFESVIRLIFEIHRSGEKGDVVVFLACEQDIEKTYELVCQEGSNLN--PDVGDLVVIPLYPKEKCSLFRPVDE-TEKRCQVYQRRVVLTTSCGESLIWS-HTVKFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEANLTSMVLFMKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINVYNAYQDTVLNSANEHCVEMWCHDCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENGLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSSYSITKK---MPEWVLFHQFSISENNYIRVASAVSPELFMQLVPQYY-FSNLPPSESKDILQQAA--GHL-PTETVNKDQDVCDKCPDATEQRCTIQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7L7V1-1", "uniprot_id": "DHX32_HUMAN", "id": "Q7L7V1-1", "name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "aln": "------------------MEEEGLECPNSSSEKRYFPESLDSSDGDEEEVLAC-------------EDLELNPFDGLPYSSRYYKLLKEREDLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGVICTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPVIEVKN-KHPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQ-GSNLN--PDLGELVVVPLYPKEKCSLFKPLDE-TEKRCQVYQRRVVLTTSSGEFLIWS-NSVRFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAEMQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHPEGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKK---MPEWVLFHKFSISENNYIRITSEISPELFMQLVPQYY-FSNLPPSESKDILQQVV--DHLSPVSTMNKEQQMCETCP-ETEQRCTLQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NYY8-1", "uniprot_id": "A0A8M1NYY8_DANRE", "id": "A0A8M1NYY8-1", "name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "aln": "-----------------------------MAGNGELSGELGKEEEDSENLFEFG------------DDLELNQFDGLPYSSRYYRLLQERKTLPVWKYRHEFMTLLENNQILIVSGTTKTGKSTQIPQWCAEFCLSAQYQHGVVVCSQIQRRQAVDLALRVADEMDVNIGHEIGYSIPLETCCSNDTILRYCTDDILLREMMSDPLLEQYGVVLVDQAHERTVSTDVLLGLLREVLLQRPELRLVVLSAPPTPETLLTHYGSVPRLHLEA-PSAGEVIHSSSSSSESFYSALRLALEVHRSREPGDVAVFLATEQEVVCACNIITKEASRMS--VSLGELLAVPMCSG-HAGICPPVTE-SPQ----MSRRIFVSCSQLEDLFWSVDSIAFVIDTGVEKRLVYNPRLRASSEVIRPISKCQAEMRKQLTGS--TGKCFCLYPEDVQ---LPAEIHPRILESNITSTALFLKRMEAAGVTHCHFINRPDPEGLMQALEELDYLAALDNDGNLSEMGIIMSELPLEPQMAKALLASCEFDCASEMLTIAAMLTAPSCFIEPPVGMLTEVMRCHMKFQHPEGDHFTLINIYNTFKRSQREP--YFSQEQWCEQYYLCCAALQTADAIRSQLSDVLKRIELPISEPAFGTKTNALNIKRALLAGYFMQMARDVDGSGNYFMLLNKHVAQAHRLSAYGAKAQKLGLPEWLLFHEYSLTDN-SIRTLTHISPHAFVQMAPQYF-FCNLPPSESKEILQNILDRDRTGIPKAKTRPEPKTETQESEAQERCVLQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53131-1", "uniprot_id": "PRP43_YEAST", "id": "P53131-1", "name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43", "aln": "MGSKRRFSSEHPDPVETSIPEQAAEIAEELSKQHPLPSEEPLVHHDAGEFKGLQRHHTSAEEAQKLEDGKINPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMP-HLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTK-DKKRADDAKNIFAHPDGDHITLLNVYHAFKS---DEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVLGHDAE------WVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQKGDVKLSLERIK--EKVDRLNELKQGKNKKKSKHSKK-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : :. . . * . :* ::* * * ::.:* :*: *. **: : .*: :**:::. * : **::*:**: :. : :: * *:* :: .:.:* ***:****::*.*:** * :*. :..***:* **.:* ** *.: * *. :::*: ***:::**:*:***::*: **:*:::: .:. . : ::...* : : . *: : . . : : * :* :::* : * **: :**: *::: . . : ...: . * * . *: : * : : * .: : : . : :*:* *..:: *****:*..* :: ***:..*: * * .** * **.*: : ..: .:*::* .* :*:: .: : .*:: * ** :*:***:*:***.**::***: :* : *::**:* :: ::.* **:* .*:***.**::.*. * . . . . * **:***:**:.:*:::: : . . **.: :* :* ** **::* :::* :* . : : **::** :*:***:*:. .*: .*: : .:: . * : . : *:::::: ::.: ** : : *. ::::.* *: :.*: .: * *:. : : : .. ", "identical_positions": 179, "similar_positions": 266, "identity": "22.74%" }, { "cls_id": "homologset.agr.HGNC:16718", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80VY9-1", "uniprot_id": "DHX33_MOUSE", "id": "Q80VY9-1", "name": "ATP-dependent RNA helicase DHX33", "aln": "-------MPEEASLPPAKRFRPGS--------CPPGRRVVMLLTAGGGG-GAGGGRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGIS--RQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEAPASQDILVFLTGQEEIEAMSKTCRDIARHLPDGCPS--MLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNP-PARRDEVQSVRKKFISS---EGDHITLLNIYRTFKNIGGN--------KDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVR----------RCMAHSLFMNTAELQTDGTYATTDTHQPVAIHPSSVLF-HCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFRRKLRTARN--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZSV6-1", "uniprot_id": "D3ZSV6_RAT", "id": "D3ZSV6-1", "name": "ATP-dependent RNA helicase DHX33", "aln": "-------MPEEAGLPPAKRFRPGS--------CPPGRRVVMLLTAGSGG-GAGGGRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGIS--RQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPS--MLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFDKFEKMAAPEIQRCNLASVMLQLLAMKVPNVLTFDFMSRPSPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNP-PARRDEVQSVRKKFISS---EGDHITLLNIYRTFKNIGGN--------KDWCKENFVNSKNMLLVAEVRAQLRDICLKMSMPIMSSRGDMESVR----------RCLAHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLF-HCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFRRKLRTARN--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H6R0-1", "uniprot_id": "DHX33_HUMAN", "id": "Q9H6R0-1", "name": "ATP-dependent RNA helicase DHX33", "aln": "-------MPEEAGFPPAKRFRPGSGPPSRAGSFPPGRQVVMLLTAGSGGRGGGGGRRQQPPLAQPSASPYPEAVELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGIS--RQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQVFYTKQPQNDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPA--MLVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNP-PSRREEVQGVRKKFISS---EGDHMTLLNIYRTFKNLGGN--------KDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVR----------RCLAHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLF-HCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFRRKLRTARN--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "X1WET4-1", "uniprot_id": "X1WET4_DANRE", "id": "X1WET4-1", "name": "ATP-dependent RNA helicase DHX33", "aln": "-------MPHEPDPPPAKRFKPGS---------PFFR------------------LDKKPGMLLPRAGHAAAGVEAQRRHLPIYQSRTQVISQLRQLHSAVFIGETGSGKTTQIPQYLYEAGIG--RQGIIAITQPRRVAAISLAGRVAEEKKVQLGKLVGYTVRFEDVTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHERTVHTDVLFGVVKAAQRRRLEQNKIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIYYTKQPQSDYLQAALVSIFQIHQEAPSSHDILVFLTGQEEIEALARTCRDISKHLPDTSGS--MTVVPLYASLPPAQQMRVFLPAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVLAVQRVSKAQAWQRAGRAGREDAGSCYRLYTEDEFENLANMTVPEIQRCNLASVVLQLLALGVPDVLNFDFVSKPSPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPDFSCTEEILTIISLLSVDSVLYNP-PARRDEVISVRKKFISS---EGDHITLLNIYRAFKKVSGN--------KDWCRENFVNSRNMGLVGEVRAQLRDICIKMNLKLESSVCDLANVR----------RCLAHGLFMSAAELQPDGSYVALDTHQPVSIHPSSVLF-QARPVCVLFNELLHTSRCYMRDLCLIQTDWLHEAAPEYFRRKLRAIKS--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VL25-1", "uniprot_id": "DHX33_DROME", "id": "Q9VL25-1", "name": "ATP-dependent RNA helicase DHX33", "aln": "-------MDSKYFATSRNDAVGPS-----PVKFSFKRKYDAMANSPILE-KKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYA--KNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTD--LRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDD-SYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSN-SEKNEMAALAHAKFQSK---HGDHLTLLNVFNGFLKSEKP--------KMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSS-DDIEMLK----------KCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP--FVKNIPTR----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36009-1", "uniprot_id": "DHR2_YEAST", "id": "P36009-1", "name": "Probable ATP-dependent RNA helicase DHR2", "aln": "MAANSNSRVASNHTSKKQKVRRNIHPFTNNTRIKRASKIVKFNDSGEGDHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRP----DLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQINQGEELG-DILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGK---ITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIMYTEYVFTTKGYARNVSRIELSWLQEVVTNAAAVAKQKVSDSK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : : : :. **::. : .:: :. .:::.******:*****:: ::* *.:*********.:* **::* :*. ***:***::.*: *:::::***:**** : : * .*: :::*******: :*:::*.:* : *:::* ***:: : *.::** . :::*** . :: : * .* :.:.: ::*:: . *:* **.*****: ..::: . : .*** *. :* * ***:::*******:**.*:: *:* *: * * :. ** .* :*::.* **:*****: * .:* * : : .: . : *** * : :* :* * : : .: :.. * : : . .* ***:. .. :* *::*. **:*: :. :: :... * .::: ::* ** : :: . . ..: . : .: . ** : * ::: : : **: :. :.: . .** *** . :: : .. : : :*: .:: . * * * : . *****:*. : :::.. : * : : *:: :. .*: *... ", "identical_positions": 164, "similar_positions": 228, "identity": "22.07%" }, { "cls_id": "homologset.agr.HGNC:16719", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R9X1-1", "uniprot_id": "M0R9X1_RAT", "id": "M0R9X1-1", "name": "Probable ATP-dependent RNA helicase DHX34", "aln": "MPPPRTREGRDHRDRDHHRAPRKEEAPEKWDWNCPETRCLLEDVFFRDEDYIRRGSEE-CQKFWAFFERLQKYQHLKTSQKEK----------DPGQPKHGIAALAD-LPCTYDPRYRINLSILGPDTRGRHG-------PGKGLPPERVSEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQCEPRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSH--APVVQVPGRLFPITVVYQPQ--------EAEQSASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEISTVLDAAQAYATLTQRWVVLPLHSALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPAASVETAILYLQDQGALDSSEALTPIGSLLAQLPVDVVIGKMMILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGLLRG--AQVVAPRDSYSRLQQRRERQTLHQLKRQHEEGGGRRRKVLRLQE--DGCSSDE-DHEGSAS-------QRADSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGPEASGREGSQDGKDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSESAVRLLATSLRLRAHWESALDRQLAQQAQRRKLEQEEDPESPAVSPQEVAALSRELLQFMA-AKVPYRLRRLTGLEAQNLYVGPQT---ITTAPSLPGLFGNSILSPHPTKGGYAVSDYLTYNCLTS---DTDLYSDCLRSFWTCPHCGLHMP-FTPLERIAHENTCP-----EAPSDGP-GSEEAAPVPTQKTSALQRPYHCQP-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DBV3-1", "uniprot_id": "DHX34_MOUSE", "id": "Q9DBV3-1", "name": "Probable ATP-dependent RNA helicase DHX34", "aln": "MPPPRTREGRGHRDRDHHRAPREEEAPEKWDWNCPETRCLLEDVFFRDEDYIRRGSEE-CQKFWAFFERLQRFQHLKTSQKKKK---------DPGMPKHGIAALAD-LPLTYDPRYRINLSILSPDTRGRHG-------PGRGLPPERVSEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSH--APVVQVPGRLFPITVVYQPQ--------EADQTASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITTVLDAAQAYASLTQRWVVLPLHSALSVSDQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPPASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGLLSG--AQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRKVLRLQE--DGCSSDEEDRKGSTS-------QRADSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGQEASGQEGSQDGRDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSESAVRLLATSLRLRAHWESALDRQLARQAQRRKLEQEEDVGSPAVSPQEVAALSRELLQFMA-AKVPYRLRRLTGLEAQNLYVGPQT---ITTAPSLPGLFGNSTLSPHPTKGGYAVSDYLTYNCLTS---DTDLYSDCLRSFWTCPHCGLHMP-FTPLERIAHENTCP-----EAPGDDP-GSEEAAPAPPQKTSALQRPYHCQVCGQDFLFTPTEVLRHRRQHV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14147-1", "uniprot_id": "DHX34_HUMAN", "id": "Q14147-1", "name": "Probable ATP-dependent RNA helicase DHX34", "aln": "MPPPRTREGRDRRD--HHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEE-CQKFWTFFERLQRFQNLKTSRKEEK---------DPGQPKHSIPALAD-LPRTYDPRYRINLSVLGPATRGSQG-------LGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSN--APVVQVPGRLFPITVVYQPQ--------EAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAG--AQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPP-------GASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEED---TPVSPKEVATLSKELLQFTA-SKIPYSLRRLTGLEVQNMYVGPQT---IPATPHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTN---DTDLYSDCLRTFWTCPHCGLHAP-LTPLERIAHENTCP-----QAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2BIE5-1", "uniprot_id": "A2BIE5_DANRE", "id": "A2BIE5-1", "name": "", "aln": "-------------------MSRKDEESRSWDWDSPRCRAQLDEVFFRQHDYIQAGSAE-HKEFWSFFERFQSFKAKKEMTASKSSRQEKHVALREGKAKKKTGCVDLGLPKDYDARYRINISVCSRDIEERLAGSDHRRRESSGPGRQEITDGRLALLHFLDFNQKQSFSKLSKLRREQKSLPIFQYRDKIVELVRTHPVVVVAGDTGCGKSTQVPQYLLASGINNIACTQPRRIACISLAKRVSFESLNQYGSKVGYQIRFETSRTLATKLLFLTEGLLLRQIQQDASLGQYQVLIVDEVHERHLHCDFLLGVLRSLLSLRPDLRLVLMSATINIKLFSSYFND--APVLQVPGRLFPIQVIYQPI--------PPEEQVSRSEKLDPRPYLRVLQGIDQRYPQEERGDLLLFLSGVAEISTIQEACQTYATHTQRWIVLPLHSTLSLAQQDKVFDIAPPGVRKCIISTNIAETSVTIDGVRFVVDSGKVKEMSFDPKAKMQRLQEFWISRASSEQRKGRAGRTGPGVCYRLYSESDYDAFAPYPVPEIHRVALDSLILQMKSMGLGDPRTFTFIDPPPASSIQTAVTYLREQGALDEHGELTSIGRLLAQLPVDVVIGKMLVLGSVFNLVEPVLTVAAALSVQSPFLRSAQHNPDCSTARQPLNSNHGDPFTLMNTFNAWVQVKADRGSGSRKWCRRRGLEEQRLYEMVNLRRQFKELLRSHGLLEDDTGRATEPQDRARRRERFTERQKLHQLKRDHELQENTKRKVLRLEEGLEGDASSGSDAEESSTSRKKRKDGAEQTMDIQEVKFKLRHNVNELQESAYASAALSSLQQALLKLLLCRGLYPQLAIPDEHNATRKDSDQVFHTRNKQGVVIHPTSVFASDPEVLHVPEHETSEFG--------QSNRHQLLAFVTLLETNKPYLSNCVRVPALQALLLVANSVNSNADCTRLVVDGWLELSLTDGDAALKVLSSALSLRAEWERLLQAQLRQSGSCSSAGFGSS--GPRVSRRELEKLCEGLVRFLLYTEVNYSLKRLTALQSQNLYIGPQQDPDLSSAAAIGSLFPGMKAEPDPIKGGLRLCSYFTYNCLCD---SQDLYSECLRKFWSCPRCDFYMP-LTPLERMQHEASCR-----PAEEQQSEDESESVNPSSSSSSALTRVYHCDICNKDLTLTSTEILKHKRQHLS--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VWI5-1", "uniprot_id": "Q9VWI5_DROME", "id": "Q9VWI5-1", "name": "ATP-dependent RNA helicase DHX34", "aln": "-------MSRIKKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGKYEAMMRSTGQPVLP-----------PRLAEAELSSMQP-YHRSKHLALRLDADELLQEARDQMQ-----------------SQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRD-GTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVA--SDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAG--RVAEDEEEQEEAQG------------DDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLFSFAIDTNAGITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESP-------SHSSDDRSSALWQDLVDYMA-LDVAYAIRRLLPADIKRLYTHQAPSARLAELKENP-FAVDFPMTPNEEKGGLNVSEHVVYSCLAEQQWTTAMDATLRAEPWQCTRCDFELEEFDVLEQLVHRSKCKRRKAQESRTAKTTSTESSTEVASSSSSHSSGGYYCNSCKRELRLTTIDILRHKKQCRNNK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . ::. : * : . : . * .** *. : : . .: .: . *:: . . :: * ** :*** *.: * :: **:: : *** :: . : : : **:***************** * :*******:**:**.***..* *.:***:*.:***** :*: *:::*:* ******: . * **:.**:**:***:*. ****** : ** **:*:::*******:.** .**.. * ::********* : * * . *: :::** *:::**. **::** .****:*:*:**: ** :: :* : **: :*:****** ::::*.**** ** *:****:********:*:**:************.:*. .* ***:***:*::*::**************:***: .:*:** .**.*** **.**:::*** **.: * *:*.**:.* . :: :: *::: **. :*.:* **:***:: ****:::**:* .* :**:** ****.*: . *: . * *..*:*::** ***.. :*.***:* *. .:*:**** *:**:*:**:.:**:**:.:*.. *:: . * : * : *: :** :. :**:*: . :.. : *:::*.*:**.: :* :: .****:* *:*****:.* .* : ..:*.***: * .: **.. ** *:*: : * :****.: :**** **** **:*:** *:***.: ::::*.. :::. **** *.*. :.:.:* :: ** .*. * :* . . * . * . *: : .: * ::** : :.:* :. : . *. *** : ....*.** . : : * *.:*.: : **:: *. .* : . . ..:. . ..:* *:*: ", "identical_positions": 391, "similar_positions": 320, "identity": "32.56%" }, { "cls_id": "homologset.agr.HGNC:16721", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "id": "O09108-1", "name": "Lutropin subunit beta", "aln": "------------------------------MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACD-------------LPHLPGLLLL---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01230-1", "uniprot_id": "LSHB_RAT", "id": "P01230-1", "name": "Lutropin subunit beta", "aln": "------------------------------MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMTCD-------------LPHLPGLLLF---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A6NKQ9-1", "uniprot_id": "CGB1_HUMAN", "id": "A6NKQ9-1", "name": "Choriogonadotropin subunit beta variant 1", "aln": "MSTFPVLAEDIPLRERHVKGRVDPHFRAPKMEMFQRLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** :* *** **** . .***: **** ***:*****.*:* ******..*:*******:*.*** ..**.:** **.**:: * *:****** **:*:**:.*****:*. ** *::*****: :*::** * **. : ", "identical_positions": 86, "similar_positions": 34, "identity": "45.99%" }, { "cls_id": "homologset.agr.HGNC:16722", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "id": "O09108-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACD----------------LP---HLPG-----LLLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01230-1", "uniprot_id": "LSHB_RAT", "id": "P01230-1", "name": "Lutropin subunit beta", "aln": "MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMTCD----------------LP---HLPG-----LLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NT52-1", "uniprot_id": "CGB2_HUMAN", "id": "Q6NT52-1", "name": "Choriogonadotropin subunit beta variant 2", "aln": "MS--KGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. :**** **** . .***: **** ***:*****.*:* ******..*:*******:*.*** ..**.:** **.**:: * *:****** **:*:**:.*****:*. ** *::*****: :*::** ** :*** :* ", "identical_positions": 88, "similar_positions": 35, "identity": "53.33%" }, { "cls_id": "homologset.agr.HGNC:16725", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LV49-1", "uniprot_id": "A0ABK0LV49_RAT", "id": "A0ABK0LV49-1", "name": "Leucine-rich repeat-containing protein 6", "aln": "MFRSLPNVQGLLLVNVGVTEDLIRRNAEHNECVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIAKIENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFIGELSSIKTLTHNIHLRELFLVGNPCADFDGYREFVVVTLQQLKWLDGKEIERSERIQALQNYAAVEQQIREQEKAYCLRRAKEKEEAQRKLEEENESEDKKKSSPGFDGDCYTDIHADCPSAMENKDHLQVPETQEQQHSTKKSDEIEDDLAFWNKPSLFTPESRLETLRHMEKQRKAQDKLSEKKKRVKPPRTLITEDGKVLNVNEAKLDFSLKDDEKHNQIILDLAVYRYMDTSLIEVDVQPTYVRVMVKGKPFQLALSAEVQPDSSSAKRSQTTGHLLICMP--KVGEMITG-QQTPMSVKTASESSKEQTKPRRKQVERLEVDP-SKHSCPDVSTIVQERKHKPKRMESQPQVEPSEAEPDFDDNPEVPPLI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88978-1", "uniprot_id": "DAA11_MOUSE", "id": "O88978-1", "name": "Dynein axonemal assembly factor 11", "aln": "MGR--------------ITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFIGELSSVKTLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQALQNYTSVEQQIREQEKAYCLRRAKEKEEAQRKLEEENESEDKKKSSTGFDGHWYTDIHTACPSATENQDYPQVPETQEEQHNTKESDDIEDDLAFWNKPSLFTPESRLETLRHMEKQRKAQDKLSEKKKKAKPPRTLITEDGKVLNVNEAKLDFSLKDDEKHNQIILDLAVYRYMDTSLIEVDVQPTYVRVMVKGKPFQLALSTEVQPDRSSAKRSQTTGHLLICMP--KVGEMITGGQRTPTSVKTTSTSSREQTNPRKKQIERLEVDP-SKHSCPDVSTIVQEKRHRPKRMESQPRDEPSEEDPDFEDNPEVPPLI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86X45-1", "uniprot_id": "DAA11_HUMAN", "id": "Q86X45-1", "name": "Dynein axonemal assembly factor 11", "aln": "MGW--------------ITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKR-SNAGFDGRWYTDIN-ATLSSLESKDHLQAPDT--EEHNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEK--QIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKPDSSSAKRSQTTGHLVICMP--KVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP-SKHSFPDVTNIVQEKKHTPRRR-PEPKIIPSEEDPTFEDNPEVPPLI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B3DH20-1", "uniprot_id": "DAA11_DANRE", "id": "B3DH20-1", "name": "Dynein axonemal assembly factor 11", "aln": "MVR--------------ISEDLIRRRAEHNNGEIFSLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQKLDLTVNFVGRLSSVETLKHNLHLKELYLVGNPCAEYQGYRQYVVATVPQLQSLDGKEISRAERIQALQELDAVRTRVLQQETKYLEEREKQKSNAN-EHPEINQS----------------------LSESQN-GTQQYPESSSKTHTEAE----DEEREFWEKPCPFTPESRLEAHRHLEEKRRANEKEKEKPK-TKTPRTLITPDGRVLNVNEPKLDFSLFEDEN-NCLLLDLHVYRHMDSSLLDVDVQPMYVRVTVKGKVFQLVLPAEVKPDSSSAQRSQTTGHLLLILP--LANEDVKPKKRTIRPTSVTSNQNNKKDTRAAPRRELLEVDPGLAGSLANIVPKGQESSHNPQRCGLEER----PVSKDFVDDPEVPPLM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VR52-1", "uniprot_id": "TILB_DROME", "id": "Q9VR52-1", "name": "Protein tilB", "aln": "MVL--------------ITEELVRKKSEHNERLISTLEEISLHQEDIEVIEHIQNWCRDLKILLLQSNLIARLENLHKLKRLEYLNVAINNIERVENLEGCESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVDYPHYRDYVVATLPQLNSLDCVEITPSERLRALRELSKNRSIIVQKQVEQDIERDEQR------------------------------------------IRVAKQQSALAEHCAGIEDEEERIKAFWQAKSEHCPEIRTEIARQHRLGRERHETKSPLDP-LKPQRNLFAPCGRPYNLNQAKLPFKFRDEAD--HYLLQLEVYRHLDTSLIDVDVQTTYTRVTVKKKIFQIAYSEEVKPDESTVQRSQITGHLVVNLKKLKVNELLIAKKSPTKSPAAPFDAGKKDGKP----------EEAFHGGVVDISNICAP--------------------------EDLPDLI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* ::*:*:*:.:***: * :***:****::*: :***.:******** **.*** ::**: :**:*****:*:**** :******* * *****:**: .*:*::.* * :*:** *:****..: **::**.*: **: ** ** :**::**:: . : ::: .* : : :: * : **: . . ** * * *: . *. ::. . *. *.*:: *: *:*:.*: *.: :: . :*:* ***::*:**::****. *.** :* * **:. . **:** *:.:*** ****:: : ..* : : . . .. ..:. . : . :: ::* *:", "identical_positions": 140, "similar_positions": 123, "identity": "28.57%" }, { "cls_id": "homologset.agr.HGNC:1673", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P04235-1", "uniprot_id": "CD3D_MOUSE", "id": "P04235-1", "name": "T-cell surface glycoprotein CD3 delta chain", "aln": "MEHSGILASLILIAVLPQGSPFKIQVTEYEDKVFVTCNTSVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEQLAKVVSSVQVHYRMCQNCVELDSGTMAGVIFIDLIATLLLALGVYCFAGHETGRPSGAAEVQALLKNEQLYQPLRDREDTQYSRLGGNWPRNKKS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P19377-1", "uniprot_id": "CD3D_RAT", "id": "P19377-1", "name": "T-cell surface glycoprotein CD3 delta chain", "aln": "MEHYGILVSLLLATVLPQGSPFKIEVVEYEDKVFVNCNTSIRHLDGSVERWLTKNKSLILGKGILDPRGMYMCNGTEELAKEVSTVQVYYRMCQNCVELDSATLAGVIITDLIATLLLALGVYCFAGHETGRLSGAVDTQVLLKNEQLYQPLRDRDDAQYSRLGGNWPRNKRS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P04234-1", "uniprot_id": "CD3D_HUMAN", "id": "P04234-1", "name": "T-cell surface glycoprotein CD3 delta chain", "aln": "MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** :* .*:* ::*.* ***** : * **:***.****: ::*:* ::. . * *** :*****:* ****: . *:***:*****.*****..*:**:*. *:**********:********* ***.:.*.**:*:*:*******:*:***:*****.*** ", "identical_positions": 104, "similar_positions": 42, "identity": "60.12%" }, { "cls_id": "homologset.agr.HGNC:16731", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91Z62-1", "uniprot_id": "FBX32_RAT", "id": "Q91Z62-1", "name": "F-box only protein 32", "aln": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGTFVSDLSSYCN-----KENLFNSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETTLHWQQQLNSIQISRPAFKG-LTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQL----DWKKMYFKLVRCYPRRE--QYGVTLQLCKHCHILSWKGTDHPCTANNPE-------------SCSVSLSPQDFINLFKF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CPU7-1", "uniprot_id": "FBX32_MOUSE", "id": "Q9CPU7-1", "name": "F-box only protein 32", "aln": "MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYSKENLFSSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNSIQISRPAFKG-LTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQL----DWKKMYFKLVRCYPRRE--QYGVTLQLCKHCHILSWKGTDHPCTANNPE-------------SCSVSLSPQDFINLFKF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969P5-1", "uniprot_id": "FBX32_HUMAN", "id": "Q969P5-1", "name": "F-box only protein 32", "aln": "MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKG-LTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQL----DWKKMYFKLVRCYPRKE--QYGDTLQLCKHCHILSWKGTDHPCTANNPE-------------SCSVSLSPQDFINLFKF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VTM4-1", "uniprot_id": "Q9VTM4_DROME", "id": "Q9VTM4-1", "name": "F-box only protein 32", "aln": "MAFISKDFRSPGETWIKTDGGWERSKVLECG-----------------------GKRKRHHSEGSSSYQDSDSSEEEAVMPPHYHITIRCTREIAGFNGLSEAVKRLDFRRSVRDRKRFHYICAFLLLVSNKGIASLPGSAQRQLLQMVEEVASHVNDSQQHPNVLRGLALKLEHIVSQENQKCWG-KPLGSTYLWKEHMATIKRIQRVASQIEIREPDPEAKPKLHELPEECVREIILCIADHRDLESAAEAWETMAKLVSEQRIWRELTRFHFNQRQIHTILDLDKFKQMGEIKDWKQIYHQLRRTYGVNDDYQFAEVLALCRSCCCLFWPSDGHPCIVDQSPDYKQRLEEAGGQLALAQPVPPAQFLKYFSL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.*:.:*:****:.*:** .**:* :.* : . .: ... :*.:. : :: .*:* *: *.**.:**** :: * :**:*: :* *:::. ::**.* **:::::::*:*. :* :.**: .::* * .* :. *: :*. :* :* * : *: ..*:* .* :. .: :** :*: ::* *** * .:* : * .:: :*:.* ::**.:***:. * *.. *: ***::*.:* * * .: *:. .* **: * * * . .*** .::. : : .:.* :*:: *.:", "identical_positions": 93, "similar_positions": 128, "identity": "24.8%" }, { "cls_id": "homologset.agr.HGNC:16732", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D1I5-1", "uniprot_id": "MCEE_MOUSE", "id": "Q9D1I5-1", "name": "Methylmalonyl-CoA epimerase, mitochondrial", "aln": "-----------------------------------MRRVVKAAALA-------------------------AGATGLFSRVQTSVAIGRSFSTPQSQFQESSPVWKLGRLNHVAVAVPDLEKASSFYRDVLGAQVSEVVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPITGFLQKNKAGGMHHVCIEVDNISAAVMDLKKKKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AMQ5-1", "uniprot_id": "A0A8I6AMQ5_RAT", "id": "A0A8I6AMQ5-1", "name": "Methylmalonyl-CoA epimerase, mitochondrial", "aln": "RVLGHCLRAPPLSCFPRPPQAPPPAHSPSCLCPGSLCKLVASGDEAGSEGRCVGCRRYRCPWRSEASDPPGAGIPGLFSRVQTPVAAGRSFSTSPSQHQASSPVWKLGRLNHVAIAVPDLEKASSFYRDVLGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPIAGFLQKNKAGGMHHVCIEVDNINAAVMDLKKQKIRSLSDEAKIGAHGKPVIFLHPKDCGGVLVELEQA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96PE7-1", "uniprot_id": "MCEE_HUMAN", "id": "Q96PE7-1", "name": "Methylmalonyl-CoA epimerase, mitochondrial", "aln": "-----------------------------------MARVLKAAAAN---------------------------AVGLFSRLQAPIPTVRASSTSQPLDQVTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ::: :. *****:*:.:. *: **. . * :..**:********:********::**:::*******.*************************** ****:*************:*******.********:******:*.***************************", "identical_positions": 130, "similar_positions": 31, "identity": "54.62%" }, { "cls_id": "homologset.agr.HGNC:16734", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M5V7-1", "uniprot_id": "F1M5V7_RAT", "id": "F1M5V7-1", "name": "", "aln": "MPGSTGQPDAGGTG------TGTTAGDPG-HPHPALAGAEDAAP--RPPPEPDDAAAALRLALDQLSALGLGDARPGDE----GMATRSADGATERGEDEPVPPDELEAAVAPPVTGAPSMGVGPSMAVAPSVTCAPSMALAPSVTSAASMAVAPSVTCAPCMAVAPSVTVAPSMALTPSVTLAPTMAVASPVAPGGLPLLDPDVSP------RPSPPDVFASFAPHPAALGPSTLLAEQLNVIGSRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILSAAEHFSLIRATR----------------SKAGGLSGATPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDAGPDSDFHANG--TDVCLDLLGAAASLWAKAPHPGRRPPTATGGLRGDNALGAASTPEPFYVGSRGGPALPDPSPSSPYGGSGNGGFTFGGDGPGAPTGTTTPEDCDFG--FDFLALDLTVPATATIWAPFERAAPLPAFSGCPTVNGAPAQPNTGTRRSSGGGGAATTPRHSPTLPEPGGLSLELPLARRGVPDPVGAVP--WRPPQSTLPPFSGSTTFSTTPSLPST--TPASSTMDTVPSEGNHKPSTTAANSSASAAAPGPPAAALARECVVCSEGEAMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFSYLRPSGSASVLDK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UE17-1", "uniprot_id": "MEX3D_MOUSE", "id": "Q3UE17-1", "name": "RNA-binding protein MEX3D", "aln": "MPGSTGQPDAGGAG------TGTTAGDPG-HPHPALAGAEDAAP--RPPPEPDDAAAALRLALDQLSALGLGGARPGDE----GMATRSADGATECGEDEPAPPDELEVAVAPPVTAS--------------------------------------------------------------------------VAPGGLPLLDPDVSP------RPSPPDVFASFAPHPAALGPSTLLAEQLNVIGSRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILS-AEHFSLIRATR----------------SKAGGLSGATPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDSGPDSDFHANG--TDVCLDLLGAAASLWAKAPHPGRRPPAATGGLRGDNALGAASTPEPFYVGSRGGPPLPDPSPSSPYGGSGNGGFTFGGDGPSAPTGTATPEDCDFG--FDFLALDLTVPATATIWAPFERAAPLPAFSGCPAVNGAPAQPNTGTRRSSGGG-AATTPRHSPTLPEPGGLSLELPLARRSVPDPVGAVP--WRPPQSALPPFSGSTTFSTTPSLPST--TLASSTLDTVPSEGNHKPSTTAANSSASTAAPGPPSAALARECVVCSEGEAMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86XN8-1", "uniprot_id": "MEX3D_HUMAN", "id": "Q86XN8-1", "name": "RNA-binding protein MEX3D", "aln": "MPSSLGQPDGGGGGGGGGGGVGAAGEDPGPGPAPPPEGAQEAAPAPRPPPEPDDAAAALRLALDQLSALGLGGAGDTDEEGAAGDGAAAAGGADGGAAPEPVPPDGPEAGAPPTLAPA--------------------------------------------------------------------------VAPGSLPLLDPNASPPPPPPPRPSPPDVFAGFAPHPAALGPPTLLADQMSVIGSRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILSAAEHFSIIRATR----------------SKAGGLPGAAQGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDAGPDSDFHANG--TDVCLDLLGAAASLWAKTPNQGRRPPTATAGLRGDTALGAPSAPEAFYAGSRGGPSVPDPGPASPYSGSGNGGFAFGAEGPGAPVGTAAPDDCDFGFDFDFLALDLTVPAAATIWAPFERAAPLPAFSGCSTVNGAPGPPAAGARRSSGAG----TPRHSPTLPEPGGLRLELPLSRRGAPDPVGALS--WRPPQGPVS-FPGGAAFSTATSLPSSPAAAACAPLDSGASENSRKP------PSASSAP------ALARECVVCAEGEVMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V4F3-1", "uniprot_id": "Q9V4F3_DROME", "id": "Q9V4F3-1", "name": "RING-type domain-containing protein", "aln": "MAAQVTPKISTCINS-----KGSIQKKNQAQHHDMSEQSKVNESTLPLSDDPRTLQLALELSLVGFNDN--------------------QNCYAQPAQPLPMPLSARSDFEIGTINST-----------------------------------------------------------------------------------------------LPIPSAPNCLLLPNAGAVSSE----------DRSKKSQNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVNKAKREILSAADHFSLIRASRKPVSDSQNNGMVGSTTSSGGGAVPRMSGPPCMPGQVTIQVRVPYRVVGLVVGPKGATIKHIQQETQTYIVTPSREKEPIFEVTGLPDNVDTARKQIEAHIALRTGSGSGSGDAITMQSSDSVDTKEYASLPSLTQILNDDLNSEILSSIYKNSVPSTQEYANNSMKTVVNVSN-SVKLVQGHHTGNCFQKSEFAEMEMTANITAADILDKRLPGNEVS--VPLAKANVANIVFRTTSSKTLSFCPPTSTSASFHSNCNANILTRSCSSASSTTSTKSTNNSANTPPEILNIWKSISDS-IDVDEGIGDSPSIWNQPANIIPTAHCSPTISISPTDSLLGMGEHSANQQNLNHAKEPIMPNLPQKIKGIQVQSNADNFLTHRECFVCNENTVTTALVPCGHNMFCMECANHICLSMDAVCPVCNSIVYHAMRILG-------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*... . . *: . :: . . :* **.*:* :. . . * * . . .: : * *. . : *:..*:.. . *** ***********************************************:********: ******* *:***:***:* *..** *** :***.***********************:***.*:******.*:***:* ***:*:*** **::*****:****: :.:* :::.. * : :.: . : .. . .: . . * . ... . : . ... : * . : : .: ..* . :.. . : ::: . * : .* .: *.. * . . :*. * . : * ** .: .:. : .. : :* . *. * . :. ..::* :.: . .: :. . .. . ***.** *. . :********:***:** :** . :. **.*.: . :*::*:. ", "identical_positions": 195, "similar_positions": 165, "identity": "25.16%" }, { "cls_id": "homologset.agr.HGNC:16735", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A5PLL7-1", "uniprot_id": "PEDS1_HUMAN", "id": "A5PLL7-1", "name": "Plasmanylethanolamine desaturase 1", "aln": "----------------------MAG---AENWPGQQLELDEDE---------------ASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99LQ7-1", "uniprot_id": "PEDS1_MOUSE", "id": "Q99LQ7-1", "name": "Plasmanylethanolamine desaturase 1", "aln": "----------------------MAG---AEDAPGRQPELDEDET--------------AEGRRWGAQHAGARELAALYSPGKRFQEWCSVILCFSLIAHNLVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTQSPETLEQLYPWECFVFCLTIFGTFTNQIHKWSHTYLGLPYWVTVLQDWHVILPRKHHRIHHVAPHETYFCITTGWLNYPLEVIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M2B5J8-1", "uniprot_id": "A0A8M2B5J8_DANRE", "id": "A0A8M2B5J8-1", "name": "", "aln": "-----------------MKQGTMAAALLSETEIRHRSMAEEDPNGNEHG-----AAARSTAPRWGPQHAGARQLAKLYSPGKRLQEWICVILCLSLFIVNLSFLFLNFSTVHIYRIIFGIVTGIVTADFASGMVHWGADTWGSVDIPVIGKAFIRPFREHHIDPTAITRHDFIETNGDNCMITILPLAHMAYKFLSYPPDALAESYPWECFVFALAVFVTMTNQIHKWAHSYFDLPRWVTLLQDCHLVLPRKHHRIHHVSPHETYYCITTGWLNYPLDRVGFWRTMEWLIERLTGQRPRSDDLAWAKKTD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V3B5-1", "uniprot_id": "Q9V3B5_DROME", "id": "Q9V3B5-1", "name": "", "aln": "MAAKSDMDILANSMYEDDPNGNLAPATTKDKESVKPEELKVTPAGTKATSPPNSATLVSTSPRWGPQNKGAQELALLYSPGKRAQEIICVYTCIGLMIINLALIVRHLRLERISVAFLSALCGIITADFASGLVHWAADTWGSVDIPMIGKNFLRPFREHHLDPTSITRHDFIETNGDNFMVGIPILGYLAHYFYIRTPSEIQQHFGWIAYVFLCSIFVAMTNQIHKWSHTYWGLPRWVLLLQSCHIILPRKHHRIHHVAPHETYFCITTGWLNWPLERIRFWSTFELIIEHFTGLKPRDDDLKWAKKLT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* : : . : ***.*: **::** ******* ** .* *:.*: ** :. ::. : * : *** **:***.*******::*::** *:*******:***:************* :: : * :*: * .*. : : : * .:** :* ::*******:*:* .** ** :**. *::***********:*****:********:**: : ** :* :*: :** :** **: **:* ", "identical_positions": 129, "similar_positions": 63, "identity": "41.61%" }, { "cls_id": "homologset.agr.HGNC:16736", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EPU7-1", "uniprot_id": "Z354C_RAT", "id": "Q9EPU7-1", "name": "Zinc finger protein 354C", "aln": "MAVDLLAARGTEPVTFRDVAVSFSQDEWLHLDPAQRTLYREVMLENYSNLASLGFQASIPPVIGKLQKGQDPCM-EREAPEDTCLDFQIQSEIEASSPEQDVFIEGPSRGLLKNRSTKCAYWKISFGELVKYERLETAQEQEKKAHEPGAASPKEVTSEDGIPTDPELEKPLFMNKALVSQETDPIERVPGMYHTSEKDLPQDFDLMRNFQIYPGQKPYVCSECGKGFSQSLHLLEHKRIHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEKPYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTLTVHQRIHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGGQLCQCLQCGRTFTRVSTLIEHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHLKERLYKWKEYGTPFMYGSSLAPHQRCLKGEKPEDLNSSL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q571J5-1", "uniprot_id": "Z354C_MOUSE", "id": "Q571J5-1", "name": "Zinc finger protein 354C", "aln": "MAVDLLAARGTEPVTFRDVAVSFSQDEWLHLDPAQRSLYREVMLENYSNLASLGFQASIPPVIGKLQKGQDPCM-EREAPEDTCLDFEIWPEIEALPPKQDVLTKETSHGLIKNGSTKCVYWKISFGELVKTECRDIAQEQEKKVHGPGAESPKETTSEDGTPTGFEPEKPLFISKALVSQEGDPTESVPATYHTSEKDLPQDFDLMRSFQMYPGQKPHVCSECGKGFTQSLHLLEHKRLHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEKPYKCSECEKAFGSSSTLIKHLRVHTGEKPYRCRQCGKAFSQCSTLTVHQRIHTGEKLYKCAECDKAFNCRAKLHRHQRIHTGEKPYKCAECGKGYSQFPSLAEHQRLHTGEQLCQCLQCGRTFTRVSTLIEHQRIHTGQKPYQCNECGKTFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHLKERLYKWKEYGTPFIYGSSLTPYQKFLKGDKPENFNSSL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86Y25-1", "uniprot_id": "Z354C_HUMAN", "id": "Q86Y25-1", "name": "Zinc finger protein 354C", "aln": "MAVDLLSAQ--EPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKLIHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHWDINFEEAVEFES-EIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQSVPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTGEKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECEKAFNCRAKLHRHQRIHTGEKPYKCSECGKGYSQFTSLAEHQRFHTGEQLYTCLECGRTFTRIVTLIEHQRIHTGQKPYQCNECEKAFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHTKEKLYKWKEYGKPFICSSSLTQYQRFFKGDKAYEV----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******:*: ********** **********.***:***********.*.***: *:* :* :**:*:**** ***.*.** *.*: * ** . .**:: : .*:*::*: * * :*.*.* * *: * : :***** * ::. **** *. * *.** ..***:*: * * :* *:* **: *:****: **:*** **::*.****.*.*.***:**:*:*********.** *:********:*** *********.******..********************:**************************.**:************************:*********.*******:*** ** **:*******: ******************** *:************************************************************************************************** **:********.**: .***: :*: :**:*. :. ", "identical_positions": 408, "similar_positions": 83, "identity": "72.73%" }, { "cls_id": "homologset.agr.HGNC:1674", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P22646-1", "uniprot_id": "CD3E_MOUSE", "id": "P22646-1", "name": "T-cell surface glycoprotein CD3 epsilon chain", "aln": "MRWNTFWGILCLSLLA--------------------------------------------------------------------------VGTCQDDAEN--------IEYKVSISGTSVELTCPLDSDENLKWEKNGQELP-QKHDK-------HLVLQDFSEVEDSGYYVCYTPASN---KNTYLYLKARVCEYCVEVDLTAVAIIIIVDICITLGLLMVIYYWSKNRKAKAKPVTRGTGAGSRPRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRAV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AAG4-1", "uniprot_id": "A0A8I6AAG4_RAT", "id": "A0A8I6AAG4-1", "name": "T-cell surface glycoprotein CD3 epsilon chain", "aln": "MQWNAFWSILGLSLLAGCFLVQLPPELAGSLCLIPCSKCPSPWHRKYCYVTVGGKDLRCQFWSDRSTTLLVWNFRHSQHLLTHVSPACFPVGTCQEDIEDTVTDDGAQKQYEVSISGTSVELTCPLENEDNLKWEKNDKVLP-DKNEK-------HLVLEDFSEVKDSGYYVCYTESSR---KNTYLYLKARVCENCMEVDLTAVSIIIIVDICITLGLLMVVYYWSKKRKAKAKPVTRGTGTGGRPRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRAV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P07766-1", "uniprot_id": "CD3E_HUMAN", "id": "P07766-1", "name": "T-cell surface glycoprotein CD3 epsilon chain", "aln": "MQSGTHWRVLGLCLLS--------------------------------------------------------------------------VGVWGQDGNEEMGG-ITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: .:.* :* *.**: **. :* :: *:******:* **** .:: *::*.: : ::.:* ** *::***:::*******. .*. * ****:***** *:*:*: :*: *:******* ***:::*****:***********:*:*.* ********************************* :", "identical_positions": 115, "similar_positions": 48, "identity": "40.78%" }, { "cls_id": "homologset.agr.HGNC:16740", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZDP9-1", "uniprot_id": "D3ZDP9_RAT", "id": "D3ZDP9-1", "name": "Zinc finger and BTB domain-containing protein 11", "aln": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRQGLIEAAHLGPGGTHHTRHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDAS--EMLEELGLDLESGEESNESEDDLSNFTSPPTTASKTSKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAVLARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVA-----STQDLAAHNGAATPPGPRNEATTT-------LSSDLGHCEIVLLVNGEVPETE---------QNGEPGQQPAPQVSAEAEASVSP------------------AGCIPNPPTEMGAASLATESNQPELESAVV-REDGGVASVPPKISEENVINTSQEDSDIGNDTSPEDTCTKDFSD------------HSQSSGQPLKDEETLIEATEKTDSGQDDD----TYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMKQPKRD--------------------AKES----------------------AEETPHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPTSSSSNSTSNEASGASSEKG--RTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYFCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQ-EQESSGPQELETVVVTGETMEVLEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHMPEAE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "G5E8B9-1", "uniprot_id": "ZBT11_MOUSE", "id": "G5E8B9-1", "name": "Zinc finger and BTB domain-containing protein 11", "aln": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRQGLIEAAHLGPGGTHHTRHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDAS--EMLEELGLDLDSGEESNESEDDLSNFTSPPSTASKSSKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAVLARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVA-----STQDLAAHNGTTTPPGTRNEATTT-------LSGELGHCEIVLLVNGELPEAE---------QNGEPEQQPAPQASPEAEASVSP------------------VEGIPEPHPEMGTASLAKESNQP--ESAVT-REDGIVASVHPKISKENVTNASQEDSDTGNDTSPEDIGAKDCPD------------HSQSPGQPSKDEDTLTEATEKTDSGPDDD----TYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMKQPKRD--------------------AKES----------------------TEETAHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKEAPTSSSSNSTSTEASGGSSEKG--RTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYFCSICGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQ-EQESSGPQELETVVVTGETMEVLEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHMPEAE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95625-1", "uniprot_id": "ZBT11_HUMAN", "id": "O95625-1", "name": "Zinc finger and BTB domain-containing protein 11", "aln": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRRDLIEAAHLGPGGTHHTRHQTWHYLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDVS--EMLEELGLDLESGEESNESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVA-----STQDLRVQNGGTAPPVASSEGTTTS------LPTELGDCEIVLLVNGELPEAE---------QNGEVGRQPEPQVSSEAESALSS------------------VGCIADSHPEMESVDLITKNNQTELETSNN-RENNTVSNIHPKLSKENVISSSPEDSGMGNDISAEDICAEDIPK------------HRQKVDQPLKDQENLVASTAKTDFGPDDD----TYRSRLRQRSVNEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRD--------------------AKEN----------------------TEEASHKCGECGMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKG--RTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGMQ-EQESSGPQELETVVVTGETMEALEAVAATEEYPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVKVEVAHISGGE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1RAC1-1", "uniprot_id": "F1RAC1_DANRE", "id": "F1RAC1-1", "name": "", "aln": "MSSEESYLAIQRYLTDEREPYAPGTHGNTKRKIRKAAACYIVRNGILYYQRRQKGLDEFTELEVVLTADRRKELITEAHITSGGEHLNQQQTWEIISQKYWWRGVLKQVKDCIKECIHCQTKQEKGRNNTEDAPKQTARQVRQKISSACASEEEDDEIH-------EDLEEEQSTTVDKHELVFVDSKGIVKQFLQKHGQTMLDKLNLQRMNNEFCDITLIIEGEEYRAHKAVLASCSDYFYELFVEKGAVSSHEAVVDLSGFSKASFLPLLDFAYTSNLTFNFCVMAEVATLARHLLMAEVLQICESVHKKVEEQKLMVYQRGDIHTVLPNQPASTQPITPTAAETYVVTMQSDGTAEAGQSLAVITSEIGTAESLALLAGATVDGETMTVVTHSGQAGSAESLAMVAHSGQAEEGETMTLVTHSGQAGSGESLAVVQACWSVEEPQVGDTPVVQSMQTGAFLISVDPGKTGASEIVHLAAAAPPAVQDEPQASKPIHQTEPPAAAPQPSPAPLKRRPGRPPKVKQQEPPPPLPSEDEPMEMEGVEDDEKQEDECIDPNKRYLRKRSVREGGYVRLHMGLETEEEEK--ITSPPAKIPQKGLAKRGRPVQSAKKNPETEFSETNLEAAPNAIVTSAKEPEPVIVEQPETVEEGALPGDPEGAVEGEHACNECGMVFQRRYTLIMHALKHEKARIFKCSICNKEFQYAASLRAHLARHKHQKSQRASLTRAMATEDSQGSDDQARFRTRREFVCDICGKTMPKLYSLRIHMLNHTGVRPHSCKVCGKSFATKHSLKMHRALHDSLKRFHCTVCEKSFVTKRSLEEHTSIHTGESKYLCTTCGASFHRASGLSKHLKKHQPKPEVRSFHCSHCDKSFFEAKDLQQHMNKHLGLKPFQCQVCGKCYSWKKDWYSHVKSHSVAEPFRCNVCGKEFFEKALFRRHVKKATHGKKGRVKQNLERECEHCGRKFTQLREYRRHMNNHQGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPLCQEAHIDARTLRKHITKFHGDQLPGKIMLEKDTLQFHNQGTQVEHAVSILSSELPPELQPPQPPATEEIETVLITEETVEAVQAMNDGAAVTTLSDQSIMQVVNYVLAQQAAVKVEEAPEIIQTMEVEVAHVAEVE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******* ** ****:*********.**.***********:**.* *******: . *:****** .:**: ** **: .** * .::***. :*:.*****:****** **:* :** * ::.* :: : : .:: .:.*. *:*.:*:: : :...*.********:**:**: ** *::*.:** **:.*:***:**:******:***:**:: *:** :**:*****************.********:***** *:*:** **:** *****:*:***:******* :**::* **::*:::** *** : . : .:.*: :. ::* .* : *: * : * * *. . * :** . : . .:: . : . : : : . : : . . . : * :: .. .: . : *. * .:: * ::* . : **:***.**.*:*** *:*.: ::: :.....: : *.:**: ::..*:: *** : * * *.****** ***::*** ****:** :**.:*:*:***:******* **.::.: :* :.: :.* * *.::. **:***:*.***:*:***********:****:**:*:****:* **.**:*::**:* *:*:* :* *********:** *********:*: ** ****.******:**********.:**::*:******:**:********:******.*.******************:**:***:*****:*******************.****** *::******************:************************************:*.**:*********:**** * :* ****************** ******:: : * :.. * * : .. * *.:*** * :: .:*:****************** . *:.*..* ***::*****:. *", "identical_positions": 576, "similar_positions": 260, "identity": "49.87%" }, { "cls_id": "homologset.agr.HGNC:16743", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3K2-1", "uniprot_id": "D4A3K2_RAT", "id": "D4A3K2-1", "name": "", "aln": "MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEGSPGGSVGNKGSSPPPYAALTPHLPAEDATVPNQESPTALCTLIPRMASMKLANPVTFLSLKTFCLGSKQVPRLKLQENQDQTPSSPASPETSLNSTGPAPTPLPDQVGCRPTSLRPDTCPLPGPGEPNPRSKQDGPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGVHGAIKKRKAPVKFLTTVLGKSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGTAQDIISTIGQAFELRFKQYLKNPSLNT-WEREEVLVDGTSEDR-GHDYYNSIPGKQPPAGGIADVRIQVQA-DPVAYCPIRCEKLCYLPGTSTCSGVYKNCMGRSRPIGIPHERAMQS--DAASLRHFWRVDLFDDPCYVNT---QNMRGCAGNQSSTLPQGSPWHLGKAPETVQPGATAKPGSSHALPHIKQQLWSEECFHGRLSRGAAERLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMDNSLPIISSGSEVSLKQPVKKHNNPGLSHSKK----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6S5L9-1", "uniprot_id": "SHC4_MOUSE", "id": "Q6S5L9-1", "name": "SHC-transforming protein 4", "aln": "MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEGSPGGSVGNKGSSPPPYPALAPHLPTEDATVSSQESPTALCTLIPRMASMKLANPITFLGLKTFCLGTKQVSRLKLQENQDQTPSRPASPESNLNRTGPAPAPDPDQVGRRPTSLRPDTCPLPGPGEPSPRSKQDGPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGAHGAIKKRKAPVKFLTTVLGKSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNPSLNT-WEREEVLVDGAPEDR-DHDYYNSIPGKQPPEGGISDVRIQAQATDQMAYCPIRCEKLCYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQG--DTPSLRHFWRVDLFDDPCYVNTQALQSMHSYAGNQSSALPQGSPWHLGKAPETVQPGATAKPGSALALPHIRQQLWDEECFHGKLSRGAAEKLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMDNNLPIISSGSEVRLKQPIRKYDNTGLLPPKK----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6S5L8-1", "uniprot_id": "SHC4_HUMAN", "id": "Q6S5L8-1", "name": "SHC-transforming protein 4", "aln": "MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V3C8-1", "uniprot_id": "Q9V3C8_DROME", "id": "Q9V3C8-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------MPKNGDAG-----------NRSGSGTTS--------------DGCIYPD---------------DVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAA-GLKSAGKRR--LTNFIS---DRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSR---LND--PSADCNINQSCKEN-VKEYYNDLPNKLPP------------------EVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSN-----------------LIDLNSPP--------------PDQTTNKLGHFDPLQATTAANSVLPSVRDVFDGPQCP------LTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISEDSELVLRNPVRRPQQDQAASPITSASS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. * . :*..... * * *. : ::* *: : *** **:** **:**** ***::**.*.*:***. * :.* *:* .:*:: .:..:*.:* ** :.:*: :*:* *::. ::****:* ******** ** *::**:**: : ***::*** .* ::*:* ***:** ***: : ** : :: ::. ::***.:*.* ** * :: * . .. * : : :.* : :** . * ..: . .* : .*.::* *.. .. . * * :*. :** :* ** :********* . **:**:**:* .*****:**** *****::**.:.***.** : *****..**: *::*::: :: . . ", "identical_positions": 154, "similar_positions": 132, "identity": "24.29%" }, { "cls_id": "homologset.agr.HGNC:16744", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LV60-1", "uniprot_id": "F1LV60_RAT", "id": "F1LV60-1", "name": "", "aln": "-----MFNQQLQQ-----QQQLQQLQQQQLQQQ---QQQILQLQQLLQQSPPQASLSMPVSRGLPQQSSPQQLLNLQGLNSTSLLNGSMLQRALLLQQLQGLDQFAMPPATYDSASLTMPTAALGNLRAYNVTAPNLAAPSLTPPQMVTPNLQQFFPQATRQSLLGPPPVGIPINPSQH---NHSGRNSQKQPRTPSSTTPNHKDSSSQTVPLDDREDPTEGSEEATELQMDTAEDQDSLVFPDGLASEPQVHEPEPEPFEALEPPAKRLRSSEESTEKGPTGQPQARVQPQTQMTAPKQTQTPDQLPEPPEALVVPRIQPQVLQIQT-----------------LSKLQKQAQTQTSPEHLAPQQNQVQPQVR--SQPQWQLQP-----------------WETDPPKQAQAQTQP----QPLWQAQSHKQAQTQTQTHPQVSTQAQPQEQ------------TSEKTQDQPQTWPQGSAPPPEQASVPACATEPQLLSNAAEVGRDPEETLPEPVSAQSSEDRSQEPSAGGLDVGECEKRAGEVLGMWGAGSSLKVTILQSSNSRAFNTTPLTSGPRPGDSASATPALASTPSKQSL-------------QFFCYICKASCSSQQEFQDHMSEAQHQQRLGEMQHSSQTCLLSLLPMPRDILERETE---DPPP--KRWCNTCQVYYMGDLIQHRRTQEHKVAKQSLRPFCTICNRYFKTPRKFVEHVKSQGHKDKAQELKTLEKETGSPDEDHFITVDAVGCFESGQEEDEDDDEEEEEEIEAEEEFCKQLQSRETSSEQWKDSETYSPNTAYGVDFLVPVMGYVCRICHKFYDSNSEFRLSHCKSLAHFENLQKYKAK-NPSPPTR-----------PVSRKCAINARNALTALFTSSSGSSRQPSPQDTVKIPSKVTCFPEAVILAFRARIHRHA---------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ULV3-1", "uniprot_id": "CIZ1_HUMAN", "id": "Q9ULV3-1", "name": "Cip1-interacting zinc finger protein", "aln": "-----MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQF---NLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVQPQAHSQPPRQVQLQLQKQVQTQTYPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPGVWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQAL-------------QFFCYICKASCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDE---EPPP--RRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDD--EDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTR-----------PVSRRCAINARNALTALFTSSGRPPSQPNTQD--KTPSKVTARPSQPPLPRRSTRLKT----------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TMZ0-1", "uniprot_id": "A0AB32TMZ0_DANRE", "id": "A0AB32TMZ0-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEKGLFSYQKEASVQNINKKKENVHNVAGKSNGQPRKANMNSDVRRAGTTG-----------------QIPHSSVPEQAEPPLKKHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRLNEQDYESANGDKTQHSPKENSASISDHKEDNNGNAQLEEDSEDQSRAAEVQGVGTSLKVTIQRSSESRAFSTSPEEMAAGAGHDGEKD------RSKHTV-------------KFTCHICKLSCPDMQDFQTHMISSDHQKRMMEIQHVSNIRLATPVPQTQQSLQGTHR---ERRTGNQRWCPTCQCHFTGDLIEHRRTKKHKMAKVSSRPFCTLCERHFRTPRKFVEHMKSSEHKRRVEELR---HEGDPEVMEELITVDAVGCFEGEDDYEEDG------NEEEFAVFEKHPAHREMAPEETAAYEAYDPDTQYGTSFVVPVAGFLCKLCHKFYHFESSARETHCRSLVHFQNLQKHNALKMQKKTSHNDCESDVSSNSPMRDPPGSSCTNEMSAISDSSQSDLSRSRVSSFREHLHSRKLKPSKKPRKSKSARSKCSVAPQKSAVVMKHFICAPHGGSRSSLESHCRESNKPDSSVQMQHVECESSVKEKISCDPVDYLEEREIVSSTPTHCLWHVSGLEHVKKSIEVKETVSRIHAKHTSHVHKNSTSISANAVKDT--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3AS23-1", "uniprot_id": "A0A8M3AS23_DANRE", "id": "A0A8M3AS23-1", "name": "", "aln": "------------------MVRMFNPHQHQQQQQHQFHQHLRQLQQLFQQQTPPPPPPPP-----PPPQPPPAHHITHHHQAARYPHAAPPHTNTAHTRPMAVPAPAPPPARMVNLCSATQTIIAPNPMLQGALLMQQMQGSMRGFAMGGQQFPPFFAAGSRASLLGPVPMGVAIKTPHMGFPRHFTPHARYFPNDYQTPQPDRKREIEQKSANISSGHSAASSSNGQPEAARSSNGQSAAKSSSSNDQSAANSSSNGQSVASSSNGQSEAKSSSSSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSRADEAVAVADPGSQGSSEQPDEPAAKKHKTQESEEPLEKDSAENTECKSPADAGDSLPEESVVNEPPATEAEEQCQADKQTDAADVDQPISGAPADAGSSDSVSAVKQPEAAPVQHQLTDT----AAAAESSS-------------SFFCYICNITCHNQQNFQSHMNGLTHQQKMMEIQHMSNACLVTLLPRVQESLQGAARKDGEKRPGLQRWCSTCQTHFTSNVMEHRRTKEHKRFSRSSSSSCTVCKLNFRTAREFVEHMQSAEHKQRVQQLWK---ESGSGSVEELNTVMLLGEDDGEFCSDDER-------EDEENGKEGLSAQMEVTMEDLDEDEEFDSDTVYGSSFVVPVSGFLCRLCDQFYHYESSARHAHCKTLKHFQNLKRYKALKKHEDSGS--------TSAEAAEEVAVAAAEGLLIAEESSVDPSASPITNTSSTPPQQEEKLEPEETLKPEPEPESELEEKLEPEPELEERSSERGRGRTSAKRRGRGGRRR-----------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P41073-1", "uniprot_id": "PEP_DROME", "id": "P41073-1", "name": "Zinc finger protein on ecdysone puffs", "aln": "---------MVSVKVNGNPQNRLVNNAKVNGNMAFRGNQNRNRNFGGGNNNYGGPMGANRMGGMNMSPWESQNPGGGQFGNNMRQGGGQMNAQAINLANNLLNNLFRNQNPPSLLDLPRGGGGMGNRNQRGGPMVSRGGGAGNRLNNRRGQGGGFQNRGATGSGPKPPPKQGGGGIRKQ---NAFDRAKKLLAKNANQNKKKEPTPGEKKIESPTKESPYASVPNDMFYCHLCKKHMWDANSFENHIKGRTHLMMREGIEESYRLKANMIRQEAKIAEQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKSIEFDRLKRMGKSKQRQLDYCTMCDLNFHGHISTHRKSEGHLQLKKFLHPKCIECNKEFATRIDYDTHLLSAEHLKKAAENNTKVGERKRQTLPISTEEEETRDLRLPQKRKKKPVKKEGEAADGEAKKEGAGD-------------GEGAEGDEAEGEEAKEGEEAADETKEGDELNESQEEEEVALPVDPEDCILDFNDGDE-------------IPSEVDTRLPKYNWQRAVGPGLISKLECYECSVCSKFFDTEVTAEIHSRTATHHRNFLKFIN------EKSSDTKIAQKRAAAALEENERKKRK-------VEEAEAPAAEGAAEETTEG--AEGELYDPSEATGDDEDVEMVDDNAEGEGEGEGDEEAEAEVEEDGAGQDNGEEEMEAQEEEGQEGEQ-------EPEPEPAPVQTPAPAEPAPPAKTPAKTPTKAAAPAAVASPAAAATSADASPSPAKKATPARAAAGAKATPQRQRARGRYNRY-------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VT61-1", "uniprot_id": "Q9VT61_DROME", "id": "Q9VT61-1", "name": "", "aln": "MRGRGGFIPRGGGTTRGGYYNNRNSSNYVNTRTQGNYRPNNGRYENNYHNNNNRYNNHNNSGGGAGGNSHYDNRSRDKFTHHNSSSGRYESSSSSHKRSYDSSRDRSDDRKRPRQDDYRRTSSSNDRSDRPSSSSQNIGSSSSNYHQRSSTGGGGNNGGSSSSYRPRDDSTSGSRHQRD---GSMGPPKRMMRSVAGTNYISRPRGTMSMRGGMMRTGMRVGGMRVVRTRVNESNDLRTMRRQLLYAQQKDRARLLKIQQLKSSLRRQRQGGNSSDDSSGKEDKDGEDAEKSKKKKGKDKDADGGDESDDDDDDEEDDDEKDEKSK-----------------------------------------------------------------------------------------------------------------------------------------KTSPGKKRNKSANNEDKSEAEGNDDDDDDDDEHGDGDDDDDKDLNESDPKSAKADDASDDEDVKVKGDGEDGDGDKSDEKAKSSVEKSGKKKDKDDAKDSKSKKSSSTKKERTSRKDKDKESSGDDRSKERRSSRHRDEDHNNRKRSFIKLICVHCRIKCVTFKEYNYHLNSRSHKNSMRQVALNQRADLQRMRARQRTTQREIEEN--SKEEHESRYCRLCRLAYRQPKNLHQASEHHKTIKKFLMPYCGSCHLAFKNAMLYENHRCSLDHIRNKARNDE--SGSDDSVDEREIDLNKFHTVDSVGEIDVDMIDADVDAMVTEAEAALKSEDEETRKRALIGPDYIKVIEAFYCELCNHYSAKADDVSLEDYTKKHCMQHSHVKAFLRNKEETEKKNKTEEGDEDDHDDDKKAGDDDADGDEDIDGKLNEDDDEYDDDGDAEVEEGDATNDKKMWEEVDKDLGDLLAEVETRGHKEDEEDEEDESVLNIDIESEKNKAKDGKEEANGDTDEGAAKENAPVAKSPEKKHAASAPTTPTAKTTAAASQPAKMATPKPTAKATKPGPASTKRNVLVSVKRTSAAAIKAATKSASNAAAADSK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. . . . . . : . . . .. .. . . :: : . . : : .. * . . .. : : . * * * . * : * . . : . : : . . : : . : : . : ", "identical_positions": 6, "similar_positions": 50, "identity": "0.56%" }, { "cls_id": "homologset.agr.HGNC:16746", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F2Z3T4-1", "uniprot_id": "MBNL2_RAT", "id": "F2Z3T4-1", "name": "Muscleblind-like protein 2", "aln": "-----MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSREN--CKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHP--VPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKALKRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQ-HTAFIPT--VPMMHSATSATVSAATTP-----------------ATSVPFAATATANQIILK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C181-1", "uniprot_id": "MBNL2_MOUSE", "id": "Q8C181-1", "name": "Muscleblind-like protein 2", "aln": "-----MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSREN--CKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHP--VPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKALKRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQ-HTAFIPT--VPMMHSATSATVSAATTP-----------------ATSVPFAATATANQIILK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VZF2-1", "uniprot_id": "MBNL2_HUMAN", "id": "Q5VZF2-1", "name": "Muscleblind-like protein 2", "aln": "-----MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSREN--CKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHP--VPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVM------------------AFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQ-HAAFIPTGSVLCMTPATSIDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BFL2-1", "uniprot_id": "A0A8M2BFL2_DANRE", "id": "A0A8M2BFL2-1", "name": "", "aln": "-----MALNIASIRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCTREN--CKYLHPPAHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMIPGTTMQP--VPTFPVSQGLGSNPGLSYAPYLTPMSHGMGLVPTEMLPSTPVIVPGSPPVSVPSSSSTQKLLRTDKLEVCREFQRGNCARGETDCRFAHPSDSPMIDTSDNTVTVCMDYIKSRCSREKCKYFHPPAHLQAKIKAAQHQANQTAVAAQAAAAAMTQS---TAKAMKRPLEASVDLAFPHGVLQPLPKRPALEKSNGASTLFNPSVLHYQQALASAQLQQPTAAFFPTGSVLCMAPASSIDHLEVNHRRGTGCQEAALRNPKRS-PCKYDLPSPLELQQPAC-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O16011-1", "uniprot_id": "MBL_DROME", "id": "O16011-1", "name": "Protein muscleblind", "aln": "MANVVNMNSLLNGKDSRWLQLEVCREFQRNKCSRQDTECKFAHPPANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHPPQHLKDQLLINGRNHLALKN----ALMQQMG-IAPGQPVISGQVPAVATNPYLTGIPANSYSPYYT-----TGHLVPALLGPDPVTSQLGPVVPQTVQVAQQKIPRSDRLETSPLAAHHHQQQQQLQHQLNN------INNNNN---------------------HSTAGAAATSTTATTTTNNAAAAAAAAAAAAAAA------------------VMGHHTLEVGKKRAADTTDMFPLVFFCSFPSPCVFAFLNCSIFGFLRLWFSLFNLRH--------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: :*::** *****::**..***.* ******** . :*:**:* **:**:****.*:: ***:*** *** ** *****:* :: * *** : ** .: . **:.... : .. *::** : * : . :* . ** .* *. . . : **: *:*:**.. : : : : : :: : *:..:* *..* *. .:* :*::*.** ***** : .: .*. ** * .. . ..* . *: ...: ::. : ", "identical_positions": 96, "similar_positions": 93, "identity": "23.88%" }, { "cls_id": "homologset.agr.HGNC:1675", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P11942-1", "uniprot_id": "CD3G_MOUSE", "id": "P11942-1", "name": "T-cell surface glycoprotein CD3 gamma chain", "aln": "MEQRKGLAGLFLVISLLQGTVAQTNKAKNLVQVDGSRGDGSVLLTCGLTDKTIKWLKDGSIISPLNATKNTWNLGNNAKDPRGTYQCQGAKETSNPLQVYYRMCENCIELNIGTISGFIFAEVISIFFLALGVYLIAGQDGVRQSRASDKQTLLQNEQLYQPLKDREYDQYSHLQGNQLRKK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q64159-1", "uniprot_id": "CD3G_RAT", "id": "Q64159-1", "name": "T-cell surface glycoprotein CD3 gamma chain", "aln": "MEQGKGLAGLFLVISLLQGTMAQQKEEKHLVKVDDSQGDGSVLLTCDFNEKTITWLKDGHRISPPNATKSTWNLGNGAKDPRGMYQCRGAKKKSQLLQVYYRLCENCIELNMGTVSGFIFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLQNEQVYQPLKDREYEQYSRLQGNQVRKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P09693-1", "uniprot_id": "CD3G_HUMAN", "id": "P09693-1", "name": "T-cell surface glycoprotein CD3 gamma chain", "aln": "MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** **** *:*.* *****:** : ::**:* . : ********. *.*.*:*** *. . *..****..****** ***:*:::.*: ******:*:****** .*:***:***::***.**:***:******************* *:*:******** :***:*****:*::", "identical_positions": 117, "similar_positions": 42, "identity": "64.29%" }, { "cls_id": "homologset.agr.HGNC:16753", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08709-1", "uniprot_id": "PRDX6_MOUSE", "id": "O08709-1", "name": "Peroxiredoxin-6", "aln": "-------------------------------------------MPG-GLLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNGETPTEKLPFPIIDDKGRDLAILLGMLDPV--EKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTG-TKPVATPVDWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRYTPQP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O35244-1", "uniprot_id": "PRDX6_RAT", "id": "O35244-1", "name": "Peroxiredoxin-6", "aln": "-------------------------------------------MPG-GLLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPIIDDKDRDLAILLGMLDPA--EKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTA-SNPVATPVDWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRYTPQP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P30041-1", "uniprot_id": "PRDX6_HUMAN", "id": "P30041-1", "name": "Peroxiredoxin-6", "aln": "-------------------------------------------MPG-GLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA--EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTA-EKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VQI7-1", "uniprot_id": "Q9VQI7_DROME", "id": "Q9VQI7-1", "name": "1-Cys peroxiredoxin", "aln": "-------------------------------------------MSGKALNIGDQFPNFTAETSEGRIDFYDWMQDSWAILFSHPADFTPVCTTELSRVAALIPEFQKRGVKPIALSCDTVESHKGWIEDIKSFG---KLSSFDYPIIADDKRELALKFNMLDKD--EINAEGIPLTCRAVFVVDDKKKLRLSILYPATTGRNFDEILRVIDSLQLTQ-TKSVATPADWKQGGKCMVLPTVKAEDVPKLFPDGIETIELPSGKSYLRITPQP", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A1Z892-1", "uniprot_id": "A1Z892_DROME", "id": "A1Z892-1", "name": "1-Cys peroxiredoxin", "aln": "------------------------------------------------MRLGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAHSVDALNSHVDWVNDIKSYCLD-IPGDFPYPIIADPTRDLAVTLGMLDEE--QKKDPEVGKTIRALFIISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPTVTDEEAHKLFPKGFDKVSMPSGVNYVRTTENY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A1Z893-1", "uniprot_id": "A1Z893_DROME", "id": "A1Z893-1", "name": "1-Cys peroxiredoxin", "aln": "------------------------------------------------MRLGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAHSVDALNSHVDWVNDIKSYCLD-IPGDFPYPIIADPTRDLAVTLGMLDEE--QKKDPEVGKTIRALFIISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPSVTDDEAHKLFPKGFDKVSMPSGVNYVRTTENY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34227-1", "uniprot_id": "PRX1_YEAST", "id": "P34227-1", "name": "Peroxiredoxin PRX1, mitochondrial", "aln": "MFSRICSAQLKRTAWTLPKQAHLQSQTIKTFATAPILCKQFKQSDQPRLRINSDAPNFDADTTVGKINFYDYLGDSWGVLFSHPADFTPVCTTEVSAFAKLKPEFDKRNVKLIGLSVEDVESHEKWIQDIKEIA---KVKNVGFPIIGDTFRNVAFLYDMVDAEGFKNINDGSLKTVRSVFVIDPKKKIRLIFTYPSTVGRNTSEVLRVIDALQLTD-KEGVVTPINWQPADDVIIPPSVSNDEAKAKFG------QFNEIKPYLRFTKSK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :.. *** *:*: * * *::: :** :***** *********:. * *** **..* :. * : ::.* * :**: .. :*** * *::*. .*:* : * * :*:.. .:*::* : ** :.*** .*:**.: :**** : *.** :* . . :: *:: ::. * .: . *:* * . ", "identical_positions": 70, "similar_positions": 65, "identity": "25.83%" }, { "cls_id": "homologset.agr.HGNC:16754", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96P50-3", "uniprot_id": "ACAP3_HUMAN", "id": "Q96P50-3", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3", "aln": "--MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLK-DALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCG-QPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCE--LGNSAVNQIYEAQC-EGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSD----GSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAG-SPTELQFRRCIQE------------------------------------------FISLHLEES-----------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6A5L6-1", "uniprot_id": "A0A8I6A5L6_RAT", "id": "A0A8I6A5L6-1", "name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "aln": "--MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLK-DALTVVVDDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGESVLQRVQSVAGNSQCGDCG-QPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCE--LGNNTMNQIYEAQC-EGPGIRKPTASSSRQDKEAWIKDKYVEKKFLRKLTSAPVREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAGTMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSD----GSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDG--EAEAWSLADVRELHPGLLAHQAARTRDLPALAAALAHGAEVNWADTADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREAEAPPGQPGPLPGSSPTELQYRRTILIPALPAAAEAHVDFLPALPPSFTPWAGPLIGPVVPYVGGPPMPSISLFLEESQDRGWAPLHTMGSLVWSRALSWSLCKHCPGSIHGQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VCQ6-1", "uniprot_id": "Q9VCQ6_DROME", "id": "Q9VCQ6-1", "name": "", "aln": "MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNSTSN-------------KIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQSTNAPNNS----------LPAKRRIHWEEFLKIPGNAYCCDCR-SPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMME--LGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLS-LGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQES--TDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGEDETYKNVMKDFSKLPASQTR-----------------------------------------VLRQRHDSNTLESQRSSLTNSD-----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04412-1", "uniprot_id": "AGE1_YEAST", "id": "Q04412-1", "name": "ADP-ribosylation factor GTPase-activating protein effector protein 1", "aln": "------------------------------------------------------------------------------------------MDFYTTDINKNVVPLFSKGTVARTASKAQYPSWCNNALKLTNILLKSLRCKFQTNRCEDDRGFEVYCVILKS--------------IALLMAAKESLILLQIPPSLPSGFPFRSPQLSFTYLSTRLSGSQHKSTHSHHINHQTHPIHSSSSNSNSNNRIPTKTDSSKQ------------------------------HTQHFSFANAGASNR-------------DELLSIVRKIDK----------------------------------------------------------------------------------------SNLKCCDCGSTATVEWVSINLLCILCIKCSGVHRSLGSHISKIRSLTLDNFTSLELMHLLQNNVSNSNVNAIYESNL-RNFPVKKITANSDDSERSKFIIDKYQFKKFVIDSNQGREASLKSLIKAIHLDSVFMMQRAIAQSKYSLRELTAS-------------EKEQNDLNHSSIFQYSLKHYEIVDG------------------------------------------------------------------TPIFFITEFLLCNGIHIDNLPKITTNWSPKVLEYWETKLEMYGTFQAVNTSR---------PRSGPHLNMHSNVDSASSYNKKHD---------LRVNIPERSASASKRWSLSSIPKS-SQNLMSPTNLLTMHKSLKLAKKDKK-----------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:: ::: .: .: . . : . : *: : :* : *: : . .. *. : : * : * * ** : : .: .: . . . : . : :. : * .: : * : : : * :. *: :. .* * ** . .*.**** ***:***:***** * **:****** : . : : : :.*. :* ***:. . :* * ... :. :* ** ::*: .. . : . . . . .:.. .. :. . :: : . * . :** : : . * : : . .*. :: .. . :. : . *: . . : .* . . :::: .* : ..: . ", "identical_positions": 61, "similar_positions": 140, "identity": "6.61%" }, { "cls_id": "homologset.agr.HGNC:16758", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9UBW8-1", "uniprot_id": "CSN7A_HUMAN", "id": "Q9UBW8-1", "name": "COP9 signalosome complex subunit 7a", "aln": "-------------------MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "G3V8Z9-1", "uniprot_id": "G3V8Z9_RAT", "id": "G3V8Z9-1", "name": "", "aln": "MGCTCSRKLEARAPHQGAAMSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELADSDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANLHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CZ04-1", "uniprot_id": "CSN7A_MOUSE", "id": "Q9CZ04-1", "name": "COP9 signalosome complex subunit 7a", "aln": "-------------------MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPASGTNQRQPSKKASKGKGLRGSAKIWSKSN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9V4S8-1", "uniprot_id": "CSN7_DROME", "id": "Q9V4S8-1", "name": "COP9 signalosome complex subunit 7", "aln": "-----------MTQDMLLGNEEPSKSKETFLEKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDSKHFETLNLFAYGTYKEYRAQPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVRHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLINLKKVLKSQTSDSDESMQID-----THGPGTSGGLGQSELRKKPSKLRNPRSAAVGLKFSK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03981-1", "uniprot_id": "CSN9_YEAST", "id": "Q03981-1", "name": "COP9 signalosome complex subunit 9", "aln": "-------------------------------------------MVMREETIKSLEDPYKYHY--------KEEWLNTKDPDEQQLFEIFAFGNIKDLPEN----IILTSLMRSKLEKLTLVTLSEIYNELSYELIKEECQIEDDGIIESHLIQ--LQNIFKAEMDSVSKSMKFSRR---------------------FDCRDVYCHEKELTIIKNPR-----VTKEYLVQNLRSWETKLKQNILE-------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: : ** * : : : : .. . : :**:*. : : ** :.**.:*::*:*: : :.* :: . : : :*. :*: ::::..: . .: ::.. .* * : * . *: : .:: . :. :* ", "identical_positions": 21, "similar_positions": 62, "identity": "7.14%" }, { "cls_id": "homologset.agr.HGNC:16759", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VGR8-1", "uniprot_id": "Q9VGR8_DROME", "id": "Q9VGR8-1", "name": "", "aln": "------------MRCAVPNCRNFSDCRSKRNAAQQQRLG----------------FFRFPKCPDTFKAWLAFCGYTEESLKLKNPCICIEHFKDED--IEGSLKFEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLEELQK------------------CRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAES--------------------PAAQDPLSVALGAKIFKELLDQYTGKEKAR---------LRKGAPIASKPKAKEKAAGEQKPKRSANPKTKE--ERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKR-----INPKPMPKPRESVR---YQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMHQD------------NARKLGVVQIVATE---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q6NX49-1", "uniprot_id": "ZN544_HUMAN", "id": "Q6NX49-1", "name": "Zinc finger protein 544", "aln": "MEARSMLVPPQASVCFEDVAMAFTQEEWEQLDLAQRTLYREVTLETWEHIVSLGLFLSKSDVISQLEQEEDLCRAEQEAPRDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPSTLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCFHGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCIECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRT-HTGEKPYECNLCGKSFSQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQLIRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRTHTGEKP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . *:: . :: *: * *: .. . :: :* :*: : :. : ::::.*. . .*...: : :. . .* :: : .::*.. * ::*.* * : .*..:* . *: . *. *:. . . . :.:::**:: .: * . * .: ..* : .. : ::** :.: .. . . . *:. *: :: : .* .: * *.:: . .*: : :**.:. * :: . :.. :. : :: . :. :.:.*:. : .* *.: * :.. *. . ** :::: :** :. : :.. : *** : :::: : * :**::* *::* * ** * ::**:* *:* : * :* * * **.*: *.:*.::*: .. .*: . * :: *.: : : * . *:*. * * ::..* * * ::**. :.*:*:.*.*::. ..:* ** * ::* :*: * *.* : : * *: ****:*: *. *. * . *: ** . : :. : :* * : . * ", "identical_positions": 115, "similar_positions": 231, "identity": "16.06%" }, { "cls_id": "homologset.agr.HGNC:16760", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZU52-1", "uniprot_id": "D3ZU52_RAT", "id": "D3ZU52-1", "name": "", "aln": "MQQWEASGGTAPVTGRRRQKSAGRRSDHGSLTTCRQALGGRDIGEENRVGGDRSQDQRMAGEQKPSSN---LLEQFILLAKGTSGSALTTLISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSAAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIQKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKKTLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BV13-1", "uniprot_id": "CSN7B_MOUSE", "id": "Q8BV13-1", "name": "COP9 signalosome complex subunit 7b", "aln": "----------------------------------------------------------MAGEQKPSSN---LLEQFILLAKGTSGSALTTLISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSVAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKKTLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H9Q2-1", "uniprot_id": "CSN7B_HUMAN", "id": "Q9H9Q2-1", "name": "COP9 signalosome complex subunit 7b", "aln": "----------------------------------------------------------MAGEQKPSSN---LLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V4S8-1", "uniprot_id": "CSN7_DROME", "id": "Q9V4S8-1", "name": "COP9 signalosome complex subunit 7", "aln": "-----------------------------------------------------MTQDMLLGNEEPSKSKETFLEKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDSKHFETLNLFAYGTYKEYRAQPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVRHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLINLKKVLKSQTSDSDESMQIDTHGPGTSGGLGQSELRKKPSKLRNPRSAAVGLKFSK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03981-1", "uniprot_id": "CSN9_YEAST", "id": "Q03981-1", "name": "COP9 signalosome complex subunit 9", "aln": "-------------------------------------------------------------------------------------MVMREETIKSLEDPYKYHY--------KEEWLNTKDPDEQQLFEIFAFGNIKDLPEN----IILTSLMRSKLEKLTLVTLSEIYNELSYELIKEECQIE------------------------DDGIIESHLIQLQNIFKAEMDSVSKSMKFSRRFDCRDVYCHEKELTIIKNPR----VTKEYLVQNLRSWETKLKQNILE--------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: : ** * : : : : :. : :::**:*. : : *: :.**::**:*:*: : :.* :: .: :: ::* . ::* ..: :::: * :: : : .:: : :: . :. ** . ", "identical_positions": 19, "similar_positions": 60, "identity": "5.74%" }, { "cls_id": "homologset.agr.HGNC:16761", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LHV0-1", "uniprot_id": "A0ABK0LHV0_RAT", "id": "A0ABK0LHV0-1", "name": "", "aln": "MTKPKKKKGSSFCCLEP-RPPRLGWGMVFLHSKTKDKAECASVSRVPPVFHFNPRHCEQLKNHYLKSAAANLSFSQDVRWQRGLPSMPFSQYSFKHIYNTEDIVPPLQTRKIQTKKPERTRILYTTTLLPEVITHFTKTYTSTLFPEDFTGFAKTQKSDGSKK-VKPKPEGPEQKAFPGQSRYHKLKPYLLDLTPSLDESLEERETWLPPAEKEARGWEAIVLEKLDKRTSRWIQSKRPVRPGQSPNKWQPFLRQQYDWSHIRDELTSSSDLELLKKLEAEETAEFMGESAPPPPKEIKKPELLLPVYFRLPGYSPQVYAAETLG-NNMTAKWILEERSNIQYLPKNPFRQVNPKAGEYAYSTDNAFEQEIYFDGVKIVHQIGGRKDQIVLENLNRYDKHLTKVFPETPEKWSLQPFPEMPYKFKKGVQRWTALPTQAKGLLLQVGEEDSSAKTRRQKKQVTPLKENVTWELTVLRKMLQEWKTSWALIIEWHHETVENLLRGIQSMYDDIRIQAITTCATAVLERPRVAANPEDP-----GPIIVDLPEVLLSALETALSDSNPNVRMAAAICQYSIQSHNPTAQDIMETALTKGNS---VDSWAAAQCLALAGIATYPVIKRILHQLFYKNNEATERQACELLNHLRVNSTLIHTMLAVELNSRQWRDRIVACRAFSQISGKVCIDMKQKIIQLMWNDWNKEVRQAAAKALGQMNLGKEVHDMIRIKLCQGNSQERIKALSLIRGLKIMTAKLLPSFLTCLSDEFTGIRQAACLAAGALKIRDEMVLERLLNLMLTDPYWKIKAFAIRALGQIGQVSPQLTNNLLWAIHYEDAPGVRLEACRSIQALNLQGNKVRDTFLDVLLLEKHEAVLREIDQTMTVLNLEKEGNQEMIQEIKNKIQTLNQKDLLTEKILKIELAIQNLKKTAKWVYSQPKEGQKPLEFYTFLQNFKTSQSEEALLRPEVLDTEKIIKNVMPRVPNPWLQSPVVGLPT-HRNRSPYFRDLRTAREKRIERGPFGYDPVLQSDSFLKEDCLPTPSLLSFRGSQLLSRLNDSSDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9Q357-1", "uniprot_id": "E9Q357_MOUSE", "id": "E9Q357-1", "name": "", "aln": "MAKPKKKKGSSSHCLEP-QPPRLGWGMVFLHSRPTDKAGCASVSRVPPVFHFSPRHCERLKTQYLKRAAANLSFSQDVGWQRGLPSMPFSQYDFKHIYNTENILPPPQTRTTDTKKPECTEALYALTLLPETITHFTKTHTSNFLPEDFTYLAKCSK--GSKKPNKPKPRDTEQKAFPGQSRHHNLKPETLELSASPDESLEERETWLPPGEKEARGWEAIVLEKLDKRTSRWIQSKRPPRPGQSPNKWQSFLRQQYDWSHIRDELTSSSDLELLKMLEAEETAEFMGESIPKPPKETKKPELLLPVYFRLPGYSPQVHTAEAMSGNNMTAEVIQAEISNMRHMTKSRFRQVNRKAGEYAYATDNTFEQEMYFDGVRIVHQIGGRKDQIVLENLNRYDKHLTKVFPETPEKWSFQPIPEMPYKLRKGVQRWTALPTEAS--LLQVGKEATSAKTRRQKKQVQPVEEDVPWELAILRRMLQEWKTSWGLIIEWYHETVENLLRGIQSMYDDIRVQAIITCATAALERPRIATTPENS-----EPIIVDLPEVLLPVLEDALSHRNPNVRMAAAVCQYCIQSHNPTARDIMQTALIKGNS---VDSWAAAQCLALEGIATYPVIKRILHQLFHKNNQATEEQACILLNHLRVNKTLIHTMLAVELNSRQWKDRIVACRAFSQITGKVCIDMKQKIIQLMWNDWNKEVRQSAAKALGRMNLGKEIHDMIRVKLCQGNSQERIKALSLIRVLKLMTAKLLPSFLTCFSDEFTGIRQAACLAAGALQIRDRMVLERLMNLMHTDPYWKIKAFAIRALGQIGLVSPQLTNKLLWAIHYEDSPGVRLEACRSILALKLHGAQVRDTFLDVLLLEKHEAVLKEIHQTMKALNLEKEGSQEMIQEIKKKIQTLNQKDILTEKILKMELAVKKLKETAKWVYSEPKADQKPLEFYSFLQKFKPSESK--------------FRGETEGEPIP----------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86WZ0-1", "uniprot_id": "HEAT4_HUMAN", "id": "Q86WZ0-1", "name": "HEAT repeat-containing protein 4", "aln": "MTRTQKGKTFLPHCFYQSLPPRLGWGMILNYSKLKGKEECASVSSVPMVF-FSSQYRLHRKSQYLKMAAANLTFSQEVVWQRGLPSIPYSQYSFDHLYNTNDIIHTPQIRKARPQKPVSFKFLGSSSPLTGDTSLAVKTESS-ANPE--------------KKLKKSKPASTVREAPRPLIHHPCMHPDMLGRPPSLDVNLEEREAWLLPPEKEARAWEATVLEKLNERTARWIQSKRPRRPGASPNKWQSFLRQQYDWSHIRDELTSASDLELLKQLEAEETAEFEDQSVILPPQEKKKPELLLPVYYRLPSYFQQAETVEIMP-GNKSTEDIHEKTSLSQPQTQSYFRQVTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFPETPEKWSAQAIPEASYRPVQGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQAKSLQEDVTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALERPRIATSQRDS-----DKTIQDLPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNIMQTALLKGNS---VDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLSEKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRRAAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSDDFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELTDLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMKILNLGNEGNQEMLQEIKNRIKTLSQKDLLTHKILKLEMVMGKVREEAKRVYLKPKGEQGPLTLQTLLQETFQDEMVLPRRPSEVCDTEAVIKPVKPRAPNPWLQSSVPGLTTRSKVRSSLVKDLRTSPEKRIAVGPFRSDYPALYLGKFSERTFFSPIMSSPSGKKGAHL-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AJZ3-1", "uniprot_id": "A0A8M3AJZ3_DANRE", "id": "A0A8M3AJZ3-1", "name": "", "aln": "--------------------------MNPLHAKWRPEQ-------------HSKRREERLYKKLLNNASQCLSFSEDVITEMRP--ISYKEMDFSWLFHATGPLAPSTRLKKIRRNKKIHNLNNPLT----------------------------------QEAGKSSVQASAKNDVSDVFRKTKPFGLLNAHTCLRETFIEDWEVQNNRCPELAANTNQQLQLGKKHRIADYIFSPAS--------------------TNVQNHLNTKIRVKHIKIPQAPRLQDILNPHASSHGSEQK------------------------------------MVSAGTDKALKEKQQGMDRQPTEIDYIHQHGLRPLDFNGQDSEMPKLSVAEISALRYAVDKWRIACNVKLPECCQRG-----------------------------------------------------------------------------ASWQSVTLKSLQRDLCDPNYQVRLEAIVTCASRAVHGPQQELDHGKAGQHWNRLKLKAITQKLLAIIIAALDDPVKRVRMAAAVCQYAMRMPNAHARDILLSMIKQDLSGAGTDSWVAAQCLAIEGNASQAVIQRLLSQHFLRDAPLDQEKSMMLLSKISSKTTLVRSLLAEELNNANWTARVQACNSIAKLKSPINKDVCTKLLHVMWNDWSGAVRHAAALALSKLDAAKEMHAELSTKLEEGPSARRVEALTFIGQLNIMTPTLLPTFLRCFNDDCEAVRKQACLTAASLMMKDQSVLDQLINLMQNEPLWEVKVDAINALGNIGWLNPALQELLMWAVHHEEEPGVRIAACEALNNLDAKGLQFQHFIEDRYTLEPNAEVKSHIECLLKKHGYSQQGDQSKMNDIKLQVKLMCTDHIITQKMLLMEDREQQQMLLC----------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * ::: : .. : : .: *: *: *:**::* : :.:.: .*. :::: . : . . :: . . : :: *.. . :: : . : :*: *. : * : : ..* : :* * . :::::.*.: :: :* :* . :: . .* * : :. : : :. : * :: :. : . : ::. . . : :::: . :** :: .* *::.* :.: . ::*::** ***: .:. *: .. : :.: **. : ** . .******:***.:: *. *::*: : : :. * .***.******: * *: .**:*:* * * :. :.:: **. : :.**::::** ***. :* *: **.:::::.. : *: *::::*****. **::** **.::. .**:* : ** :* * .*::** :* *::**..***:** *:.*: .:*: ***:*.:* ::*. **: *:*** :* *::*. **.***:** :.* * : *:**:*:*: ****: **.:: *. :* :.:. : * ** : * .: :. . ::*.*. :::** ::: : ..::*.*:* :* : . ", "identical_positions": 164, "similar_positions": 264, "identity": "15.5%" }, { "cls_id": "homologset.agr.HGNC:16762", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08961-1", "uniprot_id": "ZN423_RAT", "id": "O08961-1", "name": "Zinc finger protein 423", "aln": "----MSRRKQAKPRSVK-VEEGEASDFSLAWDSSVAAAGGLEGESECDRKSSRALED--RNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDG-CDLGLG--EEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRRDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEK-----------EAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSTPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMR-----DDGQSWSKVVYSCPYCSKR-DFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKS-----HAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPN-----ANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCS-VG-STKLESPVIQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKK--SKAEQSPVSSDVEVSSPKRQRLSGSAN-SISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQC-KEDFDSQESLLQHLTVHYMTTSTHYVCES-CDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGN-----------PAKAHKCIFCGETFSTEVELQCHITTHSKKYNCRFCSKAFHAVLLLEKHLREKH-------------------------------------------------CVFD-------PAAENGTANGVPPTS----------------TKKAEPADLQGMLLK--NPEAPNSHEAS--EDDVDASEPMYGCDICG-AAYTMEVLLQNHRLRDHNIRPGEDDGS--RKKAEFIKG--SHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGS--------SAASSPNGQ-GLQKLYKCALCLKEFRSKQDLVRLDVNGLPYGLCAGCMARS-ANGQVG----GLAPPEPADRPCAGLRCPECNVKFESAEDLESHMQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECK---LCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQH----IFAVHGQEDKIYDCSQCPQKFFFQTELQNHTMSQHAQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80TS5-1", "uniprot_id": "ZN423_MOUSE", "id": "Q80TS5-1", "name": "Zinc finger protein 423", "aln": "----MSRRKQAKPRSVK-VEEGEASDFSLAWDSSVAAAGGLEGEPECDRKTSRALED--RNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDG-CDLGLG--EEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEK-----------EAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLG-------------------SVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMR-----DDGQSWPKVVYSCPYCSKR-DFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKS-----HAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPN-----ANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCS-VG-STKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKK--SKAEQSPVSSDVEVSSPKRQRLSGSAN-SISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQC-KEDFDSQESLLQHLTVHYMTTSTHYVCES-CDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGN-----------PAKAHKCIFCGETFSTEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKH-------------------------------------------------CVFD-------AAAENGTANGVPPTS----------------TKKAEPADLQGMLLK--NPEAPNSHEAS--EDDVDASEPMYGCDICG-AAYTMEVLLQNHRLRDHNIRPGEDDGS--RKKAEFIKG--SHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGS--------SAASSPNGQ-GLQKLYKCALCLKEFRSKQDLVRLDVNGLPYGLCAGCMARS-ANGQVG----GLAPPEPADRPCAGLRCPECNVKFESAEDLESHMQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECK---LCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQH----IFAVHGQEDKIYDCSQCPQKFFFQTELQNHTMSQHAQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q2M1K9-1", "uniprot_id": "ZN423_HUMAN", "id": "Q2M1K9-1", "name": "Zinc finger protein 423", "aln": "----MHKKR---------VEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALED--RNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDG-CDLGLG--EEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEK-----------EAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLG-------------------SVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMR-----DDGQGWTKVVYSCPYCSKR-DFNSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKN-----HAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPN-----ANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCS-VG-SAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKK--SKAEQSPVSSDVEVSSPKRQRLSASAN-SISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQC-KEDFDSQESLLQHLTVHYMTTSTHYVCES-CDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGN-----------PAKAHKCIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKH-------------------------------------------------CVFD-------AATENGTANGVPPMA----------------TKKAEPADLQGMLLK--NPEAPNSHEAS--EDDVDASEPMYGCDICG-AAYTMEVLLQNHRLRDHNIRPGEDDGS--RKKAEFIKG--SHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGS--------SAASSPNGQ-GLQKLYKCALCLKEFRSKQDLVKLDVNGLPYGLCAGCMARS-ANGQVG----GLAPPEPADRPCAGLRCPECSVKFESAEDLESHMQVDHRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECK---LCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQH----IFAVHGQEDKIYDCSQCPQKFFFQTELQNHTMSQHAQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1L1R6-1", "uniprot_id": "ZN423_DANRE", "id": "A1L1R6-1", "name": "Zinc finger protein 423", "aln": "----MSRRKQAKPRSVKAVEEAESTECASGWDSSVQTDAAVS-ERDSDRKESRAVGEDGEQSVTSHDER-VGEEDLDDDSIFTCDNCQQDFECLADLTEHRTNHCPADGDDDPGLSWVASSPSSKDVASPSQMLGDGCCDMGMGTGEEEGGSGLPYPCQFCDKSFSRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHVKLHTGDKKYSCQECEAAFSRSDHLKIHLKTHSSSKPFKCSICKRGFSSTSSLQSHMQAHRKNKEHLAKKDQGKRDGSSSDVTEQDQDLYMCDYCEETFSQTDELEKHVLTQHPQLSDRAELQCIHCPEIFSDEGTLLTHIDRTHANKKHKCPMCAEQFPSVEDVYCHLDSHRQPDSSNHSASPDPVLG-------------------SVASMSSATPDSSASLERGSTPDSTLKPGQSRRKLAPSSDHDDGTWSGKVTYSCPYCSKR-DFNSLAVLEIHLKTIHADKPQQSHTCQLCLETLPTLYNLNEHVRKAHRSSGNSASNFPLLQFSNVSAFHCNYCPDMFADINSLQEHIRVSHCLSGGVVAGSTTLEGNHAFFCNQCSMGFLTESSLTEHIQQTHCSSVGGVTKMESPVLQPSQSFMEVYSCPYCTNSPIFGSLLKLTKHIKENHKNIPLANNKRKVKVADLSPASSDVEISSPKRHRVTGDSTPAVANGDYPCNQCDLRFSSFEGFQAHLKSHLELLLRRQSCPQCNKEDFDSQEALLQHLTIHYTTTSTQYVCES-CDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACAWDFRKESDLQLHVKHSHLGHPASTG-----APGKARKCIFCGETFGTEVELQCHITTHSKKYNCRLCGKAFHAIVLLERHLREKH-------------------------------------------------CIFDGGNGNGNGGSQNGTPNGVTQSSKRSTA---------GSTAAAEQADLQNMLLKGGSQETANSHEASGGEEELDASEPMYACDICG-AAYTMESLLQNHRLRDHNIRPGEDDAGSRKKKADFIKG--NHKCNVCSRTFFSENGLREHAQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLSSSGGSGGGGGSASSSPNGQLQAHKLYKCALCLKDFKNKQELVKIDVNGLPYGLCAGCMSRG-TNGQSPTV--VVTPQEAGDKGTTGLRCSECAVKFETLEDLESHIQVDHTEMSPETSGAKKVTDASPVPKKKTYQCIKCQMTFETEREIQIHVANHMIEEGINHECK---LCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQH----IFAVHGQEDKIYDCSQCPQKFFFQTELQNHTLSQHAQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z9R4-1", "uniprot_id": "ZN423_DROME", "id": "A1Z9R4-1", "name": "Zinc finger protein 423 homolog", "aln": "MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIAN-KLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGS-YQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGN-------------------------------------------------------------------------PNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSP---------------------------SRMDFPKRSRSNHVGGTTTTATPTP----------------------LLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQE--------------------------------GEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLS------SPNSYYEHFNRLATAGTFSPR-----------------LALDLPKIKPDLGSPERESRP------------------AEDDLPTDLSNNKR-------RPLTPNPQAQTP-------LAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQ-LVCPHC-GMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPPPPPNASTATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLP-LACICCRQTLHSEFELSLHAKFHTKSSSSG------------------GSLQEPVCALCLEPLP--------DATEGPAKLCDKCCRKHNLNGKRGKHSEPATSLPAPPSAFVENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMGEHGAHSRPYDCNLCPEKFFFRAELEHHQRGHELRPQARPPAAKVEVPSIRNTSPGQSPVRSPTIVKQELYETDTVESAGVEDEPENHPDEEEYIEVEQMPHETRPSGIGSQLERSTSSA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :*: :::. * .. .* . : . ..:: :* : .::. : : : : . .*: :: . : * : .... .*. . . * * :. * * * ****:*:* **.***:* * *:::***** :**:*********** ****.:::* * .******* ******:***. .***:*::*:**:.::::* **** *:** ** : .* : .* .. . .: . *:.:* . : . ** * . . * :. *:*. :* .* *.**.* :*.** *: **:::* : *: . : .: : *:**. *.:* .* :*:* :* . :. .* . .: * :: :: * ::* . * * * *:. *::.*: * :.: : .:* : : . * : ****: :..**.*: *** *: :: **:* .: .*. : :*:. *: *.:.: *.* *.*.*:. :***:***. *.:.* :*:**.*: :*::::*:*** **:*.*: **:** **.::::::*** * * :. :*:** . .:*:*:: *:::*::::.* * ::**. .**::*::.:* :*. . .. ..*.. : .. * : .: : . . :. :: :. *:* . .. . . . : ::: .* : :* *. :* . :* *: .* *. *.:* :: :..: :: * **.* *** *:***: *** ::*.* * **:. * * . * . **. : *: * **: * :**.:*..** :. :.. : *****: : *.. * ** * : **: :. . . ** * : : :.*:.*: . : : . .: .. : : : :.. : :: :.::. ::*. : * * ..**: *.:: * . . . .: : :::.::. * :*:: : .* *:: . .: * : ", "identical_positions": 277, "similar_positions": 386, "identity": "18.87%" }, { "cls_id": "homologset.agr.HGNC:16763", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A2U2-1", "uniprot_id": "D4A2U2_RAT", "id": "D4A2U2-1", "name": "Zinc finger and BTB domain-containing protein 32", "aln": "MPQTPTRLISPYGSDRLVQLAARLRPALCDTLITVGGQEFLAHSLVLAGASPRLGCRGRWALVEGISPSTFAQLLTFVYGESVELQPGELGNLEEAARALGVQALEEACKRAQAAKNHEAGLDPGWKGHQ-QSE-FMRSSERGLGAPAERQTPEEESSSE-REQETPEEHKAPGESPEMAGGRARMR----GSEEALSPASMGYRGAETKQAEVMRGRASHRGSEESLRGCSSPLSPPGSLLTSLIPRPWWAEAPWLGEGQPALWSILLWPSRYGAPFSHSTPITAAWQVWPQDQRIPLTLNHCKGLWSENQLASSSPTPGSFPQGTEKLSPWEAEESGQGYTGTLATCVSQERRLNCPSHQHPPLPSPARSRPYSCSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCPLCRAGCPSLASMQAHMRGHSPSRLPPGWTIRSTFLYSSSRPTRASISPGSPTSSAAT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JKD9-1", "uniprot_id": "ZBT32_MOUSE", "id": "Q9JKD9-1", "name": "Zinc finger and BTB domain-containing protein 32", "aln": "MPQTPTRLVSPYGSDRLVQLAARLRPALCDTLITVGGLEFPAHSLVLAGASPRLGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKALGVQALEEACQRAQKGKDEDE-LDPGLKRHQ-QSEDFMRGSERGLGSPGEKQKPEKDFRSNGREQEMSHKHKAPGERPEMAG-ATRMM----SSE------------------EVMRGIESHKGSEESLRGCPDPLSPPGSLLTSLIPRPWWAEVPRLGEGQSALWSILLWPSRYGAPFSHSTPITAAWQVRPQDQRIPLTLNHSKALWSQNQLASSSPTPGSFPQGTESLSPWQIETSGQGFTGTLATCVSQERTLNCPSHQHPPLPSPARSRPYSCSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCPLCRAGCPSLASMQAHMRGHSPSRLPPGWTIRSTFLYSSSRPTRASSSPGSPTSSAAT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2Y4-1", "uniprot_id": "ZBT32_HUMAN", "id": "Q9Y2Y4-1", "name": "Zinc finger and BTB domain-containing protein 32", "aln": "MSLPPIRLPSPYGSDRLVQLAARLRPALCDTLITVGSQEFPAHSLVLAGVSQQLGRRGQWALGEGISPSTFAQLLNFVYGESVELQPGELRPLQEAARALGVQSLEEACWRARGDRAKKP--DPGLKKHQEEPEKPSRNPERELGDPGEKQKPEQVSRTGGREQEMLHKHSPPRGRPEMAGATQEAQQEQTRSKEKRLQAPVGQRGADGKHGVLTWLRENPGGSEESLRKLPGPLPPAGSLQTSVTPRPSWAEAPWLVGGQPALWSILLMPPRYGIPFYHSTPTTGAWQEVWREQRIPLSLNAPKGLWSQNQLASSSPTPGSLPQGPAQLSPGEMEESDQGHTGALATCAGHEDKAGCPPRPHPPPAPPARSRPYACSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCSLCGAGCPSLASMQAHMRGHSPSQLPPGWTIRSTFLYSSSRPSRPSTSPCCPSSSTT-", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. .* ** ***************************. ** ********.* :** **:*** *.********:*.******:******* *:***:*****:***** **: : .. *** * ** :.* *..** ** *.*:*.**: : **** .:*..* ***** . *: : . ******* ..**.*.*** **: *** ***.* * **.******* *.*** ** **** *.*** ::*****:** *.***:************:***. .*** : * *.**.**:****..:* .**.: *** ..*******:********************************************************.** *******************:******************:*.* ** .*:**:: ", "identical_positions": 317, "similar_positions": 72, "identity": "64.69%" }, { "cls_id": "homologset.agr.HGNC:16764", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBL2-1", "uniprot_id": "D3ZBL2_RAT", "id": "D3ZBL2-1", "name": "", "aln": "MAAESEVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHIRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNN-QHTDLCQSSDTDVKNEEENSDKDCEIIEISEDSPVNLDPPVKEEEGDALQSAAETLTSERRGVKSPELSTVDGGFKENEICILHVESIHTDDIENGQFPQPCTSSNAGMYFPETQHSVINSTVENRVTEVPGNTNQGLFSENSDGSHGTINEIQNLDENFSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKCQNLL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K088-1", "uniprot_id": "ZBTB6_MOUSE", "id": "Q8K088-1", "name": "Zinc finger and BTB domain-containing protein 6", "aln": "MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGWKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNN-QHTDLCQSSDTDVKNEEENSDKDCEIIEISEDSPVNLDFHVKEEESNALQSAAETLTSERMRMQSPELSAVDGGFKENEICILHVESISTDDVENGQFSQPCTSSKAGIYFPETQHSLINSTVENRVTEVPGNTNQGLFSENSDGSHGTVNEIQNLDENFSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKRQNLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15916-1", "uniprot_id": "ZBTB6_HUMAN", "id": "Q15916-1", "name": "Zinc finger and BTB domain-containing protein 6", "aln": "MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKDCEIIEISEDSPVNIDFHVKEEESNALQSTVESLTSERKEMKSPELSTVDIGFKDNEICILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQDQGLFCENTEGSYGTVSEIQNLEEGYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKRQSLL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****:***************************************************************:*********** ****************************************************** **********.*****:*******************:* *****.:****:.*:***** ::*****:** ***:*********** * .:*****.******:*.:**.*****:******.**:***** :****.**::**:**:.*****:*.:************************************************************************************************************************** *.**", "identical_positions": 378, "similar_positions": 35, "identity": "89.15%" }, { "cls_id": "homologset.agr.HGNC:16767", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R1M7-1", "uniprot_id": "NMD3A_RAT", "id": "Q9R1M7-1", "name": "Glutamate receptor ionotropic, NMDA 3A", "aln": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AIR5-1", "uniprot_id": "NMD3A_MOUSE", "id": "A2AIR5-1", "name": "Glutamate receptor ionotropic, NMDA 3A", "aln": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TCU5-1", "uniprot_id": "NMD3A_HUMAN", "id": "Q8TCU5-1", "name": "Glutamate receptor ionotropic, NMDA 3A", "aln": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEK--------------------RSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******************************************************************** :..*******:**.** *.**** *******:*********** **** :*:***********:******************************:************************************************* ******:**************************************************************:******* *:*******.**:*******:*::.*:*****:******* ***:***::****: **:*:*********************************:*************************:*******:*:**************************:******:************:*****************:**** **************:**.***************************************** ** *****************************::********************************** ***:***************************************************************:************:*******.**********:*********.*************************************************************************************************:******************************************************:****************:******:**********************************************:**********************:***:****:**** ******* ***:**:** ***********:*****.********* : ******* ******* ***********:*.**:*******************************:*.*****", "identical_positions": 1029, "similar_positions": 64, "identity": "90.66%" }, { "cls_id": "homologset.agr.HGNC:16768", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VHN2-1", "uniprot_id": "NMD3B_RAT", "id": "Q8VHN2-1", "name": "Glutamate receptor ionotropic, NMDA 3B", "aln": "-----MESVRTLWLSVALALA---VGSRVVRGHPQPCRVPTRAGASVRLAALLP-----RAPAARARVLAALATP--APRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNH-------ASQAPKFVLDLSRLDSRNDS-LRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAP------PGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSE-ATGRTLARFLGNTSFQGRTGAVWVTGS-SQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQ-----PGAAALRVPSPSG-----------TQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGS---VPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEG-QQERAEQ---------------ERSGP-----KDELPATDGAGRWR----RVRRAVE-RERRVRFLLEP------------------GEAGGDRP------WLCSNG-------------------PGLQAELRELELRIEAARERLRSALLRRGELRALLGDGTRLRPLRLLHA--APAES----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZU9-1", "uniprot_id": "NMD3B_MOUSE", "id": "Q91ZU9-1", "name": "Glutamate receptor ionotropic, NMDA 3B", "aln": "-----MECVQTLWLSLALALA---RGSWVVRGHPQPCGVPTRAGASVRLAALLP-----RAPAARARVLAALATP--SPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASITFPEARPELRLLQFLAAATETPVLSVLRREVRAPLGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPSGLVTLWTSR-------ASQAPKFVLDLSQLDSGNDS-LRATLALLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAP------PGPQWLLGTPLPAEALPKTGLPPGVLVLGETGQPSLEAAVHDMVELVARALSSMALMHPERALLPAAVNCEDLKTGGSE-STARTLARFLSNTSFQGRTGAVWVAGS-SQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQ-----PGAAALRVPSPSG-----------TQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFTALENGS---VPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEG-QQERAEQ---------------ECSGP-----KEEQPAADGAGRWR----RVRRAVVERERRVRFLLEP------------------GEAGGDHP------WLCSNG-------------------PGVQAELRELELRIEAARERLRSALLRRGELRAQLGDGTRLRPLRLLHA--APAES----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60391-1", "uniprot_id": "NMD3B_HUMAN", "id": "O60391-1", "name": "Glutamate receptor ionotropic, NMDA 3B", "aln": "-----MEFVRALWLGLALALG---PGS--AGGHPQPCGVLARLGGSVRLGALLP-----RAPLARARARAALARAALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGLVALWTSR-------AGRPPQLVLDLSRRDTGDAG-LRARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVP------PGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPE-SPGRFLARFLANTSFQGRTGPVWVTGS-SQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLE-----PGGASARPPPPQG-----------AQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGS---APRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEA---------------EPSGPEVEQQQQQQDQPTAPEGWK----RARRAVD-KERRVRFLLEPA-----------VVVAPEADAEAEAAPREGPVWLCSYGRP----------PAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPRRLLQARAAPAEAPPHSGRPGSQE-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P9F6-1", "uniprot_id": "A0A8M9P9F6_DANRE", "id": "A0A8M9P9F6-1", "name": "Glutamate receptor", "aln": "MNLVLFRFLAYLHVGLQVALQ---MFIYPCHLHPQPCHILARIGHTVRLGALLPTRQQSRIQGALNRALVHLRQSG-NNFLPYNLSLEVLSREPLNGDPESMFRCVCQDIVVQGVSAVLAFPQSHEELIQVEFMSSFLEIPFISIIEQGE--PLKTQNRFHLQMMTRMPPSGLSDLLLAVLLRGGWQGGAATVCPGGGNTGMLEELQQRGHLGLDGAHWHLWETLNLSRLEENISEDKVMELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWIMGYPLSLDSLHSIGSPLGLMAYGEVNRKPLNFYIRDTLQLIGRAVYAATMVRPDLALIQNMVNCFDKPNKHELPSSGQYLARFLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGLWPGVTQHQREDGPGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDEEGQCPAGQLCLDPQTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAWKGGRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMWVGIFVALHITALFITLYEWNSPFGMTPHGRNRIRVFSYSSALNLCYAILFGRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSLGFRFGTVRESSAEDYVKKSFPEMHEYMRRFNKPTTPDGVSTLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKVVPCGKRVFAVTETLQMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQKIHRAINMGCDDE-RKSEAESSDRCPTLCLSENCNLHRLPPSSSSPPSTSSTSTTTTKWNNQSVKAGREAKEQNKRVHFNLETLNSYQLQAPPHG------AERGRRGLVGSPPTQLCSNGGPNPSLSLVLSPLTCSGHSTPWEEELHELQGRIEEFRGQLRAALARRAELQRTLVRQRLSQSQNSSSYNPN---TNTLTKDINRGR-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6Z151-1", "uniprot_id": "A0A8M6Z151_DANRE", "id": "A0A8M6Z151-1", "name": "Glutamate receptor", "aln": "MNFIFYTFLAYFYLGSQIFLLHTLLLLQPAHSHPQPCHILARIGHTVRLGALLPPRQSVRVRAALHRALSGLAESG-NNFLPYNLSLDVVAREAQSGDPESLFRCVCQDIVVQGVSAVLAFPQTQEEIVQMEFMSSFLEIPFISIIEHGE--PLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSGWEESMAVLCHGWEDAGLLDLLKLQGRFGWGPSQWHLRAALNLSHSTARMAN--ISDFLSEHFNLDHSPPAS-VLLFGADPECASSVLRSAHDLGLTLPTVHWIMGHPLSPDALHSIGLPLGLLAYGEVDHKPLDFYISDALQLINRAVTAATVVRPDLALIQNMVNCFDKPNKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWEGGRLNVEEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGAVKGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMWMGIFVALHITALFLTLYEWKSPFGMTPHGRNRVKVFSYSSALNLCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDAKLHHPSQGFRFGTVRESSAEDYMKKSFPEMHEYMRKFNEPTTPDGVATLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYKVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVLPHIRRKQKFKYWLHTSQKIHRALNMTYEDV-KRQRANT---------EKSCNIQKAQP---HPPPQPAPLGSFARWNNESAKVAQEPKD-NKRVHFNLETLNTRRLLPRVVSDGGQTSSASTLSSGAGSLLARVCENGGP---VQRATSSVRSS--SPSGQDELEELQTKIEEIRGHLKAALARRAELQTTLAKERAAAALTTATTTAPPTVTATICPALTKEPTDLKR", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : :. : * ***** : :* * :***.**** * * *. * . **:****::: . ** *: * :** :. ** * ::**::: *: :.*::: * *.:*::.: .* : . ****: * . : ::*:::: .*: .:* .:: : : .*:**: : .*.. .:*:*.. : **... * :*::* **. .:* . * * *::. **. : .*: : * ::*: :*: : : ::*. **: *** * :..: :****.**** * **.* * . *:* *::.::***:**. * *:*.**.**..*:*:.: * : : . .:******:******:*: **:*:***** ***. **.* *: *: : . * :***********:*:** *:*:**:******** :.*:*:*******:* *.*************:*:*************:**::***:************ *:*:*.***:****:*:***.**:*:**:**** **************** ***:****** ***:**************************:*****:***** *****: ******* ***** *:* ***:** :**:.. **** **: *.:***:*:******:************************************* *:**::*****.*::*:*******:****************.: *::*******:*: .***: ***.*:*: **::*: .:::************:* : :.. *: . * *. :. : ::**:* **. . :*. * . **.**: :** * :*: ** **.:* * . : ", "identical_positions": 479, "similar_positions": 240, "identity": "42.05%" }, { "cls_id": "homologset.agr.HGNC:16769", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M2BIG8-1", "uniprot_id": "A0A8M2BIG8_DANRE", "id": "A0A8M2BIG8-1", "name": "", "aln": "MGLTQSSGDGPEGGTEGYHVHGVQEDSPAER--AGLEPFFDFIISIGHNRLNQENDMLKDLLKANVEKPVKMEVYSTKTMRMRELEVVPSNMWGGQGLLGASVRFCSFQGANENVWHVLDVESNSPAALAGLQEHSDFIVGADQVLQDSEDFFSLIEAHEGKPLKLLIYNTETDKCREVIVTPNGAWGGEGSLGCGIGYGYLHRIPAQPEGPKSEKVSSRESPVAGNPEQEYPTNGFSEVSLM--ASGQSLSGMDLETPLPPPIQRVMDPGFSDHSEVALMNSEVSDIADRLDLSTSSIDMTNTSLAVKEDADVSGVEELQDSDFHSGDPEEQITEEYSAVDFSSSITPPSNASPPLSLSHSLLPNPTLENSVPTDVASLMNSSIPPLDSSIPALDISSLLIDPAALHLESSALPEEHFPSETDGVS---QGFSEKPQSFEGQEEPVSSDLTSFDSHNADVEAEAALQ------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1RRZ2-1", "uniprot_id": "A0A8M1RRZ2_DANRE", "id": "A0A8M1RRZ2-1", "name": "", "aln": "MGLIQS-VFATQG---GYHVHGVQENSPAER--AGLEPFFDFILSIGHTRLNKESSTLKELLKANVEKPVKLQVYSSKVMRVRELELVPSNLWGGQGLLGASVRFCSFTGADQYVWHVLDVEVNSPAELAGLKPYSDYIIGADQVLQESEDFFSLIEACEGKSLKLLVYNTHTDRCREVLITPNAAWGGNGSLGCDVGFGYLHRIPMCP------VTSDQHQNTPEHQENKHR----SELFLV--NSTDAEEKTDAQG------GSVQDT--SEDSAQCEISPALA-LSECLDSSTSLLDASTSSLKADDD-----------------DEEE------------SAISSPK-----------------------------ISSSVLLEDSGICESQTSPAIINTTPKHDQTVKCTQKTLA------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q91X51-1", "uniprot_id": "GORS1_MOUSE", "id": "Q91X51-1", "name": "Golgi reassembly-stacking protein 1", "aln": "MGLGAS-SEQPAGG-EGFHLHGVQENSPAQQ--AGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMKVREVEVVPSNMWGGQGLLGASVRFCSFRRASEHVWHVLDVEPSSPAALAGLCPYTDYIVGSDQILQESEDFFTLIESHEGKPLKLMVYNSESDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQP------SSQHKKPPGATPPGTPATTSQLTAFPLG--APPPWPIPQDSSGP----ELGSRQSDFMEALPQVPGSFMEGQLLGPGSPSHGAADCGGCLRAMEIPLQ------------PPPPVQRVMDPGFLDVSGMSLLDSSNISVCPSLSSSTVLTSTAVSVSGPEDIGSSSSSHERGGEATWSGSEFEISFPDSPGAQAQADHLPRLTLPDGLTSAASPEEGLSAELLEAQT-EEPADTASLDCRAETEGRASQAQATPDPEPGL-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O35254-1", "uniprot_id": "GORS1_RAT", "id": "O35254-1", "name": "Golgi reassembly-stacking protein 1", "aln": "MGLGAS-SEQPAGG-EGFHLHGVQENSPAQQ--AGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRRASEHVWHVLDVEPSSPAALAGLRPYTDYIVGSDQILQESEDFFTLIESHEGKPLKLMVYNSESDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQP------SSQYKKPPSASSPGTPAKTPQPNAFPLG--APPPWPIPQDSSGP----ELGSRQSDYMEALPQVPGGFMEEQLPGPGSPGHGTADYGGCLHSMEIPLQ------------PPPPVQRVMDPGFLDVSGMSLLDSNNTSVCPSLSSSSLLTPTAVSALGPEDIGSSSSSHERGGEATWSGSEFEISFPDSPGSQAQVDHLPRLTLPDGLTSAASPEEGLSAELLEAQT-EEPAHTASLDCMAQTEGPAGQVQAAPDPEPGLCEGPW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BQQ3-1", "uniprot_id": "GORS1_HUMAN", "id": "Q9BQQ3-1", "name": "Golgi reassembly-stacking protein 1", "aln": "MGLGVS-AEQPAGGAEGFHLHGVQENSPAQQ--AGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRRASEQVWHVLDVEPSSPAALAGLRPYTDYVVGSDQILQESEDFFTLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQP------PSYHKKPPGTPPP----SALPLGAPPPD--ALPPGPTPEDSPSL----ETGSRQSDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQ------------PPPPVQRVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSSSSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPEDGLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VW57-1", "uniprot_id": "Q9VW57_DROME", "id": "Q9VW57-1", "name": "", "aln": "MGSSHS-IHVPGGGTEGYHVLKVQDNSPGQK--AGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDKPVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLRAYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIGFGYLHRIPVQAEP---VTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPAP--------PAVADVSVAQPQVQVPAPAQPLPPPANIFIPGVFDPSTQQNANALGGIPAAQLPFPQATAAPAAVPMFSAPQQAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTPLPPQMAHVFAPPVPPQAGAAPAAGNDELSGPAVNQAGN------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04410-1", "uniprot_id": "GRH1_YEAST", "id": "Q04410-1", "name": "GRASP65 homolog protein 1", "aln": "-------MFRIAKNLVRTFEQSVQDTLALSQDSSNLDAFFQSIPPN--------------LLSAQLESPVDAVSEGVKHTNVNETLSGLRIVWVDEMQFQLQSFFDYIVGFNDDPVPVVSNQHG--------FSYPDYRR-----------ITSIFNEHCGRTLKVNIWSAKGGTFRDEYIS---IISKESDDLDDVSLNHDERRPSSG------EAHQFQALGFKVQWTPLIASTFTYHILN-VNIPDGPAQSAGLIP-----DEDYIIGCQDGLLATGGETLLQDIVRSRANYDLVLYVYNKVSDCVRPIT-----------------VHIGPDGRLG--------------------------CNVGYGFLHRIPTVKHCPQQAQQQGQDDNPVPVPVPVESETAFVPSAFTAPPVPTKKKSKNKKGTQPLAMDDYFNEGRDKSSTAAKSAESDILAPPPQKQSSSD----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . **: . .: :.*:.:*: * . ** :::.** . * :.* * .: : . * : .: ::. . . :.*: : :::: :.**: ::. . . *: :. . :. .:. .: .* * . . . . . ", "identical_positions": 19, "similar_positions": 64, "identity": "3.96%" }, { "cls_id": "homologset.agr.HGNC:1677", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P24161-1", "uniprot_id": "CD3Z_MOUSE", "id": "P24161-1", "name": "T-cell surface glycoprotein CD3 zeta chain", "aln": "MKWKVSVLACILHVRFPGAEAQSFGLLDPKLCYLLDGILFIYGVIITALYLRAKFSRSAETAANLQDPNQLYNELNLGRREEYDVLEKKRARDPEMGGKQQRRRNPQEGVYNALQKDKMAEAYSEIGTKGERRRGKGHDGLYQGLSTATKDTYDALHMQTLAPR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4V7G0-1", "uniprot_id": "Q4V7G0_RAT", "id": "Q4V7G0-1", "name": "T-cell surface glycoprotein CD3 zeta chain", "aln": "MKWTASVLACILQVQFPGAEAQSFGLLDPKLCYMLDGILFIYGVIVTALYLRAKFSRSADAAAYLQDPNQLYNELNLGRREEYDVLDKKRPRDPEMGGKQQRRRNPQEGVYNALQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQTLPPR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P20963-1", "uniprot_id": "CD3Z_HUMAN", "id": "P20963-1", "name": "T-cell surface glycoprotein CD3 zeta chain", "aln": "MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***.. . *.**:.::* :**************:***********:***:**.******::.* *. ******************:*:* ******** ***:*****:** ************** *******************************:*.**", "identical_positions": 131, "similar_positions": 23, "identity": "79.88%" }, { "cls_id": "homologset.agr.HGNC:16770", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JZC4-1", "uniprot_id": "A0A0G2JZC4_RAT", "id": "A0A0G2JZC4-1", "name": "Semaphorin-6D", "aln": "----------------------------------------------------------MRFFLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQL---------MLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKG-KHKDECHNFIKVFVPRND--EMVFVCGTNAFNP-----MCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADG-------KLYSATVADFLASDAVIYR--------SMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDRDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQG-VCERVTLGMLAGGYEQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTIS----GVRWEVQSGDSNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSDKAHGHG-ASRK----EHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVP---MTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPS-FVPQTTSVRPLNKYTY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q76KF0-1", "uniprot_id": "SEM6D_MOUSE", "id": "Q76KF0-1", "name": "Semaphorin-6D", "aln": "----------------------------------------------------------MGFLLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQL---------MLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKG-KHKDECHNFIKVFVPRND--EMVFVCGTNAFNP-----MCRYYRLRTLEYDGEEISGLARCPFDARQTNVALFADG-------KLYSATVADFLASDAVIYR--------SMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDKDHHALYVAFSSCVVRIPLSRCERYGSCKKSCIASRDPYCGWLSQG-VCERVTLGMLPGGYEQDTEYGNTAHLGDCHESLPPSTTPDYKIFGGPTSDMEVSSSSVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDTKSMAVDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHSHG-ASRK----EHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQSMDHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNPKAILGEIHMAHQTLMLDPVGPMAEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVP---MTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPS-FVPQTTSVRPLNKYTY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFY4-1", "uniprot_id": "SEM6D_HUMAN", "id": "Q8NFY4-1", "name": "Semaphorin-6D", "aln": "----------------------------------------------------------MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQL---------MLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKG-KHKDECHNFIKVFVPRND--EMVFVCGTNAFNP-----MCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADG-------KLYSATVADFLASDAVIYR--------SMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQG-SCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHG-ASRK----ETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVP---MTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPS-FVPQTPSVRPLNKYTY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BLA1-1", "uniprot_id": "A0A8M2BLA1_DANRE", "id": "A0A8M2BLA1-1", "name": "", "aln": "--------------------------------------------------------MGWRELTIDLLILLLVASRLDAVSFPEDNIPLDVVDRHYARQYPVFRGRPSGNESQHRLDFQL---------MTQIHDTLFIAGRDQVYLVSLRESYRNEIIPYRKLTWRSGQADRETCAMKG-KHRDECHNFIKVLVPRND--DLVFICGTNGFNP-----MCRYYRLDNLEFDGEEISGLARCPFDAKQTNVALFADG-------KLYSATVADFLASDAVIYR--------SMGDGSALRTIKYDSKWLKEPHFLHAVDYGDFVYFFFREIAAEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFVKARLNCSVPGESFFYFDVLQAITDIIDINGVPSVVGVFTTQLNSIPGSAVCAFSMVDIEKAFRGRFKEQKTPDSVWTPFPEEKLPKPRPGCCAGHGSAESYKTSIEFPDETLQFIKSHPLMDASVPSIGDEPWFTKTRVRYRLTALAVDNTAGPHKNYTVVFIGSEAGIVLKVLAKTSLLSLNDSVLLEEIDVFNQAKCLSSNEDDRRILSFHLDKDSHTLYVAFSSCVVRIPLSRCERHSSCQKSCIASRDPYCGWMSHG-ACERIPATIQSG-YEQDVEYGNTAHLGDCHEFLATTSAPDFKSYGDPTSDMELPSSSVTVPATSEPIQSPQTN---PTQTP-QLFEPHGDPATSHSVEHIPGVLEGV-WEIQAGESNQMVHMNILISCVLAAFLLGAFIAGMVVYCYRDAFLRTPRKIQKDAESAQSCTDSTGSFAKLNGLFDSPVKEYQPNMDTPKLYTNLLSNGREVPTTGETKTMLLS--GQPPELAALPTPESTPVLQQKSLQPIKNQWERAHGKMSGSRKDAPPKSPQYLPSSPPPHSAINP-HIPSAVVLPNATHENKAGFSTPEGPQAEKKVQNSEQHGSKSG-RKDQRRTVDARNTLNDLLKHLND--SNPKAIMVEMPKSRQHLMLEPIVSPTEIPPKVPSREASLYSPSSSLPRNSPTKRVDVPTTPTSPTGHMGTLERQR-YHRGSSQRHSISSPPKGLHSPSGAIVSRQPSMNRGGYIP-PTPTPPTRLDSHGVPMAMTPSVSRQSSYSGHGSLPRTSIKRTASLKPDVPPKPNGFAPQTAQMRPVNKYSY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q24323-1", "uniprot_id": "SEM2A_DROME", "id": "Q24323-1", "name": "Semaphorin-2A", "aln": "--------------------------------------------------------MSLLQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISS-SNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQ-GDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGG-KNLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPSDK--SRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVND--------TSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYR----NGESLSKLLDIFEVAPN-------EAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCVR--DPYCGWDKEANTCRPYELDLLQD---------------------------------------------------------------------------------------------------VANETSDICDSSVLKKKIVVTYGQSVHLG---------CFVKIPEVLKNEQVTWYHHSKDKGRYEIR---------------YSPTKYIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCT-----------------------------------------------------PPNKSNDYQKIYS-----DWCHEFEKYKTAMKSWEKKQAQCSTRQN---FSSN-QHPNEIFRKPNV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4KG38-1", "uniprot_id": "A0A0B4KG38_DROME", "id": "A0A0B4KG38-1", "name": "Semaphorin-2A", "aln": "MPLNAQLKIAQSVNKVTYAKVSDSNCCAKKQQKYSIADFSQAKRQAGSMCATGKGKHRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTG--SSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQ-SICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDD--TKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHND--------TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMH----YGQRHSNLVDIFEASPHS------EPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVS--DPYCGWDKDVNACRPYQLGLLQD---------------------------------------------------------------------------------------------------VANETSGICDTSVLRKKVTSSYGQTLHLS---------CFVKMPEVLRKKQTRWYHHSTEKGRYEVR---------------YTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCS-----------------------------------------------------PPSQKQDYQKIYS-----HWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDVFSNDALVX-------PRKYLYSFEFLSSATEGVASAHRKLYIFVFVLTIFARF---------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :*. : . :: : . . : :* :*. * : .::*::.. *::: :.*.: . : .. * .*. ** . :*:*.::*: . : : :::****..** .. :* :: *:.:**:*. :...*::.:. **:.* *:* :*:**:* : . **:***** :.:*:*: :.: *::******* *.*: * *******:**:**:* ** : :: ::*::::***:***:..: ***: :*:: .: . . . ..***. *.: *****:: : :*: .* *:**** :.:*.* .. :.::*:**** * . : :** .* **:.***** :* .:* : * : .: . ::: * ::.: * : *:: .. : :: :: : . : : :.: :**:. . : :* :: * * . *: ****** .. * : :.::. : . .:* . : :: .:. *:: . :::. : ..* : :*. * : : . : . . . *.: . .: *. .:: : :* . ::.:. . .. :: : : :.. :* *: : ", "identical_positions": 143, "similar_positions": 256, "identity": "12.19%" }, { "cls_id": "homologset.agr.HGNC:16771", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3V2C1-1", "uniprot_id": "KRA93_MOUSE", "id": "Q3V2C1-1", "name": "Keratin-associated protein 9-3", "aln": "MACCATSFCGFPTCSTGGS-------------SCCQPTCTQ----------------SSCCQPSCCEASCCQPSCCETGFGG-------------------GIGCGQEGGSGGVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPSC-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A588-1", "uniprot_id": "A2A588_MOUSE", "id": "A2A588-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSSCCQPSCCQPSCCQPSCSQ----------------SSCCQPSCCQSSCCQPSCCQSSCCQPCCSQTSCCQPSCCQPSCCGTGSGQEGGSGAVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCPPSCSESNCCEPTC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O70149-1", "uniprot_id": "O70149_RAT", "id": "O70149-1", "name": "", "aln": "MACCSTSFCGFPTCSTGGT-------------------CG-----------------SSCFQPSCCETSCFQPSCCETGYGIGG-----------------GIGYGLEGGSGAVNYRVRWCRPDCRVEGTSLPPCCVVSCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCC--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0LD59-1", "uniprot_id": "A0ABK0LD59_RAT", "id": "A0ABK0LD59-1", "name": "", "aln": "MACCSTSFCGFPTCSTGGT-------------------CG-----------------SSCCQPSCCETSCFQPSCCETGSGIGG-----------------GIGYGQGSGSGAVNCRVRWCRPDCRVEGTSLPPCCVASCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPSC-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A590-1", "uniprot_id": "A2A590_MOUSE", "id": "A2A590-1", "name": "", "aln": "MACCATSFCGFPTCSTGGT-------------------CG-----------------SSCCQPSCCETSCFQPSCCGTGYGIGG-----------------GIGCGQEGGFGGVSCRVRWCRPDCRVEGTCLPPCCVVSCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCC--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IUG1-1", "uniprot_id": "KRA13_HUMAN", "id": "Q8IUG1-1", "name": "Keratin-associated protein 1-3", "aln": "MTCCQTSFCGYPSCSTSGTCGSSCCQPSCCETSCCQPSCCQTSFCGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGG------------GIGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVCCCYSCEPTC----------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:** *****:*:***.*: * *** *****::** ***** :. * * * .. *.*. *:************.******.** **********:****************.****.* ", "identical_positions": 86, "similar_positions": 19, "identity": "45.5%" }, { "cls_id": "homologset.agr.HGNC:16772", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3V2C1-1", "uniprot_id": "KRA93_MOUSE", "id": "Q3V2C1-1", "name": "Keratin-associated protein 9-3", "aln": "MACCATSFCGFPTCSTGGS-------------SCCQPTCTQSSCCQPSCCEA----------------SCCQPSCCETGFGG-------------------GIGCGQEGGSGGVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPSC-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A588-1", "uniprot_id": "A2A588_MOUSE", "id": "A2A588-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSSCCQPSCCQPSCCQPSCSQSSCCQPSCCQS----------------SCCQPSCCQSSCCQPCCSQTSCCQPSCCQPSCCGTGSGQEGGSGAVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCPPSCSESNCCEPTC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A590-1", "uniprot_id": "A2A590_MOUSE", "id": "A2A590-1", "name": "", "aln": "MACCATSFCGFPTCSTGGT-------------------CG-SSCCQPSCCET----------------SCFQPSCCGTGYGIGG-----------------GIGCGQEGGFGGVSCRVRWCRPDCRVEGTCLPPCCVVSCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCC--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O70149-1", "uniprot_id": "O70149_RAT", "id": "O70149-1", "name": "", "aln": "MACCSTSFCGFPTCSTGGT-------------------CG-SSCFQPSCCET----------------SCFQPSCCETGYGIGG-----------------GIGYGLEGGSGAVNYRVRWCRPDCRVEGTSLPPCCVVSCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCC--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0LD59-1", "uniprot_id": "A0ABK0LD59_RAT", "id": "A0ABK0LD59-1", "name": "", "aln": "MACCSTSFCGFPTCSTGGT-------------------CG-SSCCQPSCCET----------------SCFQPSCCETGSGIGG-----------------GIGYGQGSGSGAVNCRVRWCRPDCRVEGTSLPPCCVASCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCQPSCSEPSC-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q07627-1", "uniprot_id": "KRA11_HUMAN", "id": "Q07627-1", "name": "Keratin-associated protein 1-1", "aln": "MACCQTSFCGFPSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCETSCCQPSCYQTSSCGTGCGIGG--GIGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCGQSCCRPVCCCYCSEPTC----------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** *******:***.*: * :** *****:: ** ***** :. * * * .. *.*. *:************.******.** **:*******:****************.*****. ", "identical_positions": 86, "similar_positions": 19, "identity": "45.5%" }, { "cls_id": "homologset.agr.HGNC:16773", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZAY4-1", "uniprot_id": "D3ZAY4_RAT", "id": "D3ZAY4-1", "name": "", "aln": "MTNSCCSSCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCRTCFQPSCVSSCCSTPCCQPCCCVSSCCQPCCRPSCCQSSCCQPCCCE-------------------------SSCCQPRCCISSCCQPCCKPSCCQSSCCKPCCKPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0LX93-1", "uniprot_id": "A0ABK0LX93_RAT", "id": "A0ABK0LX93-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCRTCFQPSCVSSCCSTPCCQPCCCVSSCCQPCCRPSCCQP-CCRPSCCE-------------------------SSCCQPRCCISSCCQPCCRPSCCQSSCCKPCCEPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64526-1", "uniprot_id": "Q64526_MOUSE", "id": "Q64526-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCRTCFQPCCVSSCCRTPCCQPCCCVSSCCQPCCQPSCCQSSCCQPRCCE-------------------------SSCCQPRCCISSCCQPCCRPSCCQSSCCRPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A4M2-1", "uniprot_id": "A2A4M2_MOUSE", "id": "A2A4M2-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCRTCFQPCCVSSCCRTPCCQPCCCVSSCCQPCCQPSCCQSSCCQPSCCQPSCCQSSCCQPSCCQSSCCQPRCCISSCCQPRCCISSCCQPCCRPSCCQSSCCKPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYP9-1", "uniprot_id": "KRA99_HUMAN", "id": "Q9BYP9-1", "name": "Keratin-associated protein 9-9", "aln": "MT-HCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPACCQN--------TCCRTTCCQPTCLSSCCGQTSCGSSCGQSSSCAPVYCR-------------------------RTCYYP----TTVCLPGCLNQSCGSSCCQPCCRP----ACCETTC-----CRTTCFQPT-----------CVSSCCQPSCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ***.*****************:*: **:*. ******** ********:.:**:. :** *.**** * *.* *..* .** *. .* * *. :* * :: * * * ..* ****:***.* **:.:* * **:*** * ****:*. *", "identical_positions": 92, "similar_positions": 32, "identity": "43.4%" }, { "cls_id": "homologset.agr.HGNC:16775", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBD2-1", "uniprot_id": "D3ZBD2_RAT", "id": "D3ZBD2-1", "name": "", "aln": "MTGSCCGS-FSSQSCGG-CCQPCCCRDPCCCRPVSCQTTVCRPVTCVPHYTRPICEPCRRPICCDPCSLQQGCCRPITCCPSSCTAVVCRPCCWASTCCQPISVQAPCCRPPCCQPAPCRTTCRTSPCNTCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BYU5-1", "uniprot_id": "KRA21_HUMAN", "id": "Q9BYU5-1", "name": "Keratin-associated protein 2-1", "aln": "MTGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******** *** * ** ****************:*************: ***********:********:************************:*****:***:******* **:** ******.* ", "identical_positions": 112, "similar_positions": 9, "identity": "84.85%" }, { "cls_id": "homologset.agr.HGNC:16776", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1AQ85-1", "uniprot_id": "B1AQ85_MOUSE", "id": "B1AQ85-1", "name": "", "aln": "MVSS-CGSVCSEEGCG-QGCCQPSCCQTTCCRTTCCRPSCCVSSCCRPSCCVSSCCRPSCCRPQCCQSVCCQPTCCRPSCCISSCCQPSCGSSSCCGSSCCRP------CCR-PCCSP--CCSPCCRP------CCRP-CCRP----------------CCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCAIPCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BQ66-1", "uniprot_id": "KR412_HUMAN", "id": "Q9BQ66-1", "name": "Keratin-associated protein 4-12", "aln": "MVNSCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSSCCPSCCESSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.* ******::*** :.**:**************************.** * **:*:****.***:.**:.********:****:*.* .* ** .:**** *** .** * * *.**** **:* **** *************:*.*:****************:*** .**", "identical_positions": 131, "similar_positions": 28, "identity": "65.17%" }, { "cls_id": "homologset.agr.HGNC:16777", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2A588-1", "uniprot_id": "A2A588_MOUSE", "id": "A2A588-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSSCCQPSCCQPSCCQPSCSQSSCCQP---------------SCCQSSCCQPSCCQSSCCQPCCSQTSCCQPSCCQPSCCGTGS--------GQEGGSGAVSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCPPSCSESNCCEPTC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2KAC6-1", "uniprot_id": "A0A0G2KAC6_RAT", "id": "A0A0G2KAC6-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSSCCQPSCCQPSCCQPSCCQPSCCQS---------------SCCQPSCCQSSCCQPSCCQSSCCQPSCSQTSCCQPSCCGTGS--------GQEGGSGAVSCRVRWCRPDCRVEGTCLPPCCVASCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCCPPSCSESNCCEPTC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3ZBZ2-1", "uniprot_id": "D3ZBZ2_RAT", "id": "D3ZBZ2-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSNCCQPSCSQSSCCQPSCSQSSCCQPSCTQSSCCQPTCSQSSCCQPTCSQSSCCQPSCCQTSCCQPTCCQTSSCQTSCCGTGS--------GQEGGSGATSCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCHCCEPSCSKPSCSEPSC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A590-1", "uniprot_id": "A2A590_MOUSE", "id": "A2A590-1", "name": "", "aln": "MACCATSFCGFPTCSTGGTCGSSCCQPSCCETSCFQPSCCGTGYGIG----------------------------------------------------GGIGC--------GQEGGFGGVSCRVRWCRPDCRVEGTCLPPCCVVSCIPPTCCQLHHAQASCCRPSYCGQSCCRPACCCYCC--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYS1-1", "uniprot_id": "KRA15_HUMAN", "id": "Q9BYS1-1", "name": "Keratin-associated protein 1-5", "aln": "MTCCQTSFCGYPSFSISGTCGSSCCQPSCCETSCCQPRSCQTSFCGFP---------SFSTSGTCSSSCCQPSCCETSCCQPSCCETSCCQPSCCQISSCGTGCGIGGGISYGQEGSSGAVSTRIRWCRPDSRVEGTYLPPCCVVSCTPPSCCQLHHAQASCCRPSYCGQSCCRPVCCC-------------EPTC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:** *****:*: * .*****.******.:.** ** .. .. * *. ****. *..* *:******.***** ******.** **:************************.*** ", "identical_positions": 82, "similar_positions": 21, "identity": "41.84%" }, { "cls_id": "homologset.agr.HGNC:16778", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZZR8-1", "uniprot_id": "D3ZZR8_RAT", "id": "D3ZZR8-1", "name": "", "aln": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHEISLLQPTCCDPCPPPCCQPEVYVPTCWLLNSCHPTPGLSGINLTTYVQPGCENPCEPCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A591-1", "uniprot_id": "KRA31_MOUSE", "id": "A2A591-1", "name": "Keratin-associated protein 3-1", "aln": "MACCVARCCSVPTGPATTICSSDKSCRCGVCLPSTCPHEISLLQPTCCDPCPPPCCQPEVYVPTCWLLNSCHPTPGLSGINLTTYVQPGCESPCEPCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYR8-1", "uniprot_id": "KRA31_HUMAN", "id": "Q9BYR8-1", "name": "Keratin-associated protein 3-1", "aln": "MYCCALRSCSVPTGPATTFCSFDKSCRCGVCLPSTCPHEISLLQPICCDTCPPPCCKPDTYVPTCWLLNNCHPTPGLSGINLTTYVQPGCESPCEPRC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* **. *.**********:** *********************** ***.******:*:.*********.*********************.**** *", "identical_positions": 84, "similar_positions": 9, "identity": "85.71%" }, { "cls_id": "homologset.agr.HGNC:16779", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBR0-1", "uniprot_id": "D3ZBR0_RAT", "id": "D3ZBR0-1", "name": "", "aln": "MACCVTRCCSVPTGPATTICSSDKSCRCGVCLPSTCPHTIWQLEPTCCDNCPPPCHIPQPCVPTCFLLNSCHPTPDLLTVNLTTYVQPGCEEPCTPRCC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D7P0-1", "uniprot_id": "KRA33_MOUSE", "id": "Q9D7P0-1", "name": "Keratin-associated protein 3-3", "aln": "MACCVALCCSVPTGPATTICSSDKSCRCGVCLPSTCPHTIWQLEPTCCDNCPPPCHIPQPCVPTCFLLNSCHPTPDLLTVNLTTYVQPGCEEPCVPRCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYR7-1", "uniprot_id": "KRA32_HUMAN", "id": "Q9BYR7-1", "name": "Keratin-associated protein 3-2", "aln": "MDCCASRSCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPICCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQP-CCEPCLPRGC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* **.: .*******************************:* *** *************************:***.* *:****:.** * *** ** *", "identical_positions": 81, "similar_positions": 9, "identity": "81.82%" }, { "cls_id": "homologset.agr.HGNC:1678", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P05540-1", "uniprot_id": "CD4_RAT", "id": "P05540-1", "name": "T-cell surface glycoprotein CD4", "aln": "MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNK-LLIKG-SLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKE--EVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSK----AFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFAST-SITAYKSEGESAEFSFPLNLG--------EESLQG--ELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDR--GILYQEVNLVVMKVT--------QPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQE-------KVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLN-QTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P06332-1", "uniprot_id": "CD4_MOUSE", "id": "P06332-1", "name": "T-cell surface glycoprotein CD4", "aln": "MCRAISLRRLL-LLLLQLSQLLAVTQGKTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKE--EVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSK----VLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQST-AITAYKSEGESAEFSFPLNFA--------EENGWG--ELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDK--GTLHQEVNLVVMKVA--------QLN-NTLTCEVMGPTSPKMRLTLKQENQEARVSEEQ-------KVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVN-QTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRMQKSHNLI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P01730-1", "uniprot_id": "CD4_HUMAN", "id": "P01730-1", "name": "T-cell surface glycoprotein CD4", "aln": "MNRGVPFRHLL--LVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGS-FLTKG-PSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKE--EVQLLVFGLTANSDTHLLQGQSLTLTLES-PPGSSPSVQCRSPRGKNIQGGK----TLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKA-SSIVYKKEGEQVEFSFPLAFT--------VEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRAT--------QLQ-KNLTCEVWGPTSPKLMLSLKLENKEAKVSKRE-------KAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6F9-1", "uniprot_id": "A0ACD6B6F9_DANRE", "id": "A0ACD6B6F9-1", "name": "", "aln": "--------MLGLILIPLFITVLKAQESQEVIYAQVGGTVTLPRDKIERKDGNIKTQDIYVNWFLDSENTLIINRNPQISINKGTNARVSLS--ADFSLQISPVEESDFVIWRCEQHVLARNYKKTYKLYKVSIPKVPALLVGGRLFLKYVKDVSSVNPSVTWISPKNEGCQEHKNTKDTVLVPSVSTCHNGVWTCQLKYENKKTEATTTVSVIDLAPSPADPIYTSISQSSTVSIPCALSSAIPWSVLNETLQGGSWSFTPLSEPRSPLSLLTLNVGSVVRWDLANGANFTDGKRVITNHNLSIQNLPVKETIRGVYKCSLKFNTKTISREVKVEVLKVSPSGSLKVFEGTRLNVTCSLGHMNTAGLEVKWTCASNCPPFNHKSPPHLSVLSFPKIRMQDKGLVKCELWKNSQKLTSAQLYLRVEKAPVDIWLCVAIGSGVVVFILLVAFAIIYIRRHKQMMMYRRRKTRFCCCNNNKQ----PKGFYKT----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *: : : . :.: :: .: * :. *. .:: : : :*. ... .: :. . . ::: . ..*.* *. :. .* : ** . . : :: :: . ** * * * . .* .: . * .. .: ... *.* : ::** : *: : : : *.. .:. .*:* : *. * .. . :::.: . : . * : : : : * . :*. : :**:: *::.: : .:**.: .:. : : . .: . ..... . : : *: :* * .. : .:.: : : : .. :: : .: *: * :: * ::: .:*: .: : *: ", "identical_positions": 44, "similar_positions": 160, "identity": "8.91%" }, { "cls_id": "homologset.agr.HGNC:16781", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DCJ9-1", "uniprot_id": "NPL_MOUSE", "id": "Q9DCJ9-1", "name": "N-acetylneuraminate lyase", "aln": "MAFPKKKLRGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVNQGRNKLDQVVIHVGALNVKESQELAQHAAEIGADGIAVIAPFFFKSQNKDALISFLREVAAAAPTLPFYYYHMPSMTGVKIRAEELLDGIQDKIPTFQGLKFTDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKATQEFTAKAEAKLKSLDFLSSPSVKEGKPLASA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q66H59-1", "uniprot_id": "NPL_RAT", "id": "Q66H59-1", "name": "N-acetylneuraminate lyase", "aln": "MAFPKKKLQGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSISERRQVAEEWVRQGKNKLDQVVIHVGALNLKESQELAQHAAEIGADGIAVIAPFFFKSQNKDALISFLREVAAAAPALPFYYYHIPSLTGVKIRAEELLDGIQDKIPSFQGLKFSDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVLGATGAVGSTYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKATQEFTANAEAKLKSLNFLSFPGLKDGNMEACS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXD5-1", "uniprot_id": "NPL_HUMAN", "id": "Q9BXD5-1", "name": "N-acetylneuraminate lyase", "aln": "MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKLKSLDFLSFTDLKDGNLEAGS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NYR8-1", "uniprot_id": "NPL_DANRE", "id": "Q6NYR8-1", "name": "N-acetylneuraminate lyase", "aln": "MSQRVKKLTGLVAATFTPLTAEGEINLSVIAAYVDYLIEKQNVKSVFVNGTTGEGCSLTVDERKHLAAAWCQHGKGKLEQLIVHVGCMSIKDSQELARHAASIGADGISVISPSYFKPINADALRLFIKEVSASAPDLPMYYYHLPGMTGVALEAADVLNGIEREIPSFQGVKYSGTDLRDLGQCVCYSQSRDWSVLYGVDEQLLGALVLGVHGAVGSTYNYLGHIVNQMLSAFNNGNHTQTRDLQFGFMEVITFARTLGFDVSVNKQVMSEVSGLPMGPPRLPLLPCP---VSKAQAIAQKIHNFT-QGL---------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: *** ******:**:* :****:.**. *****:::*.**.:********* **::.**:::* * :*:.**:*:::***.:.:*:*****:***.******:**:* ::*. . * * *::**:*:** **:****:*.:*** :.* ::*:** :**:***:*::.*** *:**** .:.::::.*:*******.***:*. ***********: .****.**:: : : : . ** : ..*.:. .***.** .* :*: ***:********* .. . .*:* :.:. :: .: ", "identical_positions": 157, "similar_positions": 105, "identity": "49.06%" }, { "cls_id": "homologset.agr.HGNC:16782", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q496Z9-1", "uniprot_id": "TRM1L_RAT", "id": "Q496Z9-1", "name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "aln": "MENMAEEELLPQEKEE---AQVRVPT--PDSAPVPAPAADTALDSAPTPDSAPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDN--LENIQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGSRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIS--------ASTAKSSNEVLKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDGLEDCS--TAGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGVEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYKQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSVHAPSNTNKQEENGVFVKTTDDTTIDIYSAQ-GKRKSN-EMAINVAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDASLTQFKSILLKYSTPTYTGGQSEGQVP-APEDTVTDPVELSVNDKAEVSGCRRW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2RSY6-1", "uniprot_id": "TRM1L_MOUSE", "id": "A2RSY6-1", "name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "aln": "MENMAEEELLPQEKEE---AQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIA--------ASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDG--TLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQ-GKRKSN-EMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7Z2T5-1", "uniprot_id": "TRM1L_HUMAN", "id": "Q7Z2T5-1", "name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "aln": "MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIA--------ASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQ-GKRKSN-EMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7TEL4-1", "uniprot_id": "A0A8N7TEL4_DANRE", "id": "A0A8N7TEL4-1", "name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "aln": "MAELKEEDAGQLHQED-----ANIKDIVIDSSAILTESKETEQIST---------CEASTNSVKIEDKNENTTSSAVSERHVSIQTTLEGLEMLVDLNG----------------AGRKSCPLCPEEKFKACYSHKLRRHLQNLHWKVYVEFEGQRMCICHLPCRQLKSSLGSDQTPGRLVAHYHCVVCSVTIARKTDMISHLKRHINKGETEASYSGNLDVPFEEPVPCGQAYEIMKELGTNVQLLPNHTTPQKTDTYFSRKMKTNRQLVFCSLAVLAEERNPLECLDAFGATGIMGLQWAKHLRNSVKVTINDINEACVKMIKENCHLNHIRVEGNRTGRQLDGAGDPES--PIASVEVVKMDANVIMHLRPFDYIHLDPFGTAINYLDAAFRNVRNLGIVSVTSTDTGSLYSKSLNVTLRHYGCQIVRTEYYRELAARMVLASVARAAARCNKGIEVLLAVALEHFVLVVVRVLRGPTQADESAKKLRQLLHCQWCEERVFLKPGSMVEENLYRQLPCQCHGSMPGKTAVELGPLWGGPLFNTGFLRRMLVAAVQHNMEDIQPLVKTLICEADCTTLKPFPVPGHSALSNQVECGVVIKTLQKVEEADTSDQSGKRKTTGDDGGNVLKKVKPDTSLEHPAFYYSIHRHSIRGMNMPKLNKFLQYLTEAGFRVSRTHFDPTGVRTDATLAQFKEVLTKYSVPTYSSAPQSSAISSDRRQTL--------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :: **: .:*: ..: **: : : : :: *: . * : : :. . .....* *:**:*** * .** *. . . ::*****:***:* **************: ***** *******.** :*..: .:* ..:: *****::**.**:*:***:.*::**:*****:: * . . .. . *::** .*::*: **:: *****:**. *** ***::**:**.**:**:********************** *:*******:** .*.:*::*****:::* : :: .. . ..::*.:*****:****.**:********::****:****:************ .***:*: :*: *****:*******:*****:*:*:***********:***:*******************.***:***:: *:********:* * *.***** *:****:**********:******...*******:***. :::*.::***.*:**** *::**. . . . * .:* * **.:** :.. * ****:. : *: ** *.*.* **.***.******:*******:*** *::************ *:****.* ***.:* ***.***:.. ... : .:*: ", "identical_positions": 380, "similar_positions": 186, "identity": "51.14%" }, { "cls_id": "homologset.agr.HGNC:16783", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6P1J9-1", "uniprot_id": "CDC73_HUMAN", "id": "Q6P1J9-1", "name": "Parafibromin", "aln": "MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEG-HKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKG-KEETEGFKIDTMGTYHGMTLKSVTEG-ASARKTQTP-----------AAQPVPR---PVSQARPPPNQ---KKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLM-PQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8JZM7-1", "uniprot_id": "CDC73_MOUSE", "id": "Q8JZM7-1", "name": "Parafibromin", "aln": "MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEG-HKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKG-KEETEGFKIDTMGTYHGMTLKSVTEG-ASARKTQTP-----------AAQPVPR---PVSQARPPPNQ---KKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLM-PQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4V8C8-1", "uniprot_id": "CDC73_RAT", "id": "Q4V8C8-1", "name": "Parafibromin", "aln": "MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEG-HKEGIVQTEQIRSLSEAMLVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKG-KEETEGFKIDTMGTYHGMTLKSVTEG-ASARKTQTP-----------AAQPVPR---PVSQARPPPNQ---KKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLM-PQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSHLRF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "X1WHN7-1", "uniprot_id": "X1WHN7_DANRE", "id": "X1WHN7-1", "name": "Parafibromin", "aln": "MADVLSVLRQYNIQKKEIVAKGDEVIFGEFSWPKNVKTNYVIWGTGKEGQPKEYYTLDSILFLLNNVHLPHPSYVRRAATENIPVVRRPDRKDLLSYLNGESSSSTSIDRSAPIEIGLQRPTQVKRAADEVSSEAKKPRVEDEERVRLDKERLAARLEG-HKESIVQTDQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITQ-KQRSFVDAEVDVTRDIVSRERVWRTRTTILQSSGKNFSKNIFAILQSVKAREEGRAPEQRQTQNQTQVDPAIRNKQPVPAAYNRYDQERFKG-KEETEGFKIDTMGTYHGMTLKSVTEG-ASARKAQTP-----------AMQPVPR---PVSQARPPPNQ---KKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVTSEEKKKQGIQRDNEVLLQRRKDQVQPGGATLSVTVPYRVIDQPLKLA-PQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIRAFHLKYDEARMDPNVQKWDVTVLELSHHKRHLDRPVFLRFWETLDRYMVKHKSHLRF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VHI1-1", "uniprot_id": "Q9VHI1_DROME", "id": "Q9VHI1-1", "name": "", "aln": "MADPLSLLRQYNINKKEIVERDSQIIFGEFSWPKSVKTNYLKYGSGKKGAPREYYTLECLLYLLKNVMLQHSVYVRQCAAEDIPAVNRPDRKELLAYLNGETPTCASIDKSAPLEIPTQVKRAAEGEPSSVEVAAKKARFEETQ-VQKVREQLAARWDVNQKETAVNMDNIKSLSETMSVEKIAAIKAKRLANKRTTIKRTDNDEAMGTDLRAILDYDVDSTKDIISRERQWRTRTSILQSTGKIFAKNIFAMLQGIKAREEGRNRPQVPNPIKMPEPARIAKPQPQLSQYNRYDQERFNRQKEETEGFKIDTLGTYHGMSLKSVTEGSLAQRKAQANNLPGAPGVIAGAAAGRPKELLPAAQARQLPANGPSKRTSRTPIIIIPSANTSLITMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQRKRNNQ---------TVSYRVIDNPTKLS-QQEWQRVVAVFVMGPQWQFKGWPW---EGNPVDIFSKICAFHLCFSEMKLDSNVERWSVTLLRLSQNKRHMDRAVLSKFWETLDKYIAKYKPDLRY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06697-1", "uniprot_id": "CDC73_YEAST", "id": "Q06697-1", "name": "Cell division control protein 73", "aln": "MANSLDRLREHLKNGDKLVLKNN------------------------EGQSTDDITKATMVETLS-----------------------SDGSTQDSFPLNEETEIEIDGSLVQLRIIVHCWMNKDSSAADYLADCQNKQLTNVSFLQRT--DLINWLSG----NTESSQYLKAPGQKGETSDKVDIENKTLAGELSTVKSTTS---------ASLENDSEVSDPVVVET--------------------------------------MKHERILVDHNSALRGAKPINFGY---------LIKDAELKLVQSIKGSLRGSKLPPGHKG-AHGRISKTN-----------GSSGGPR---------------------KDPIILIPSAASSILTVANIKQFLLESKYVNP-----RNLPSVPNGLVNIEKNFER-----ISRPIRFIIVDNTRMFTKPEYWDRVVAIFTTGHTWQFNNYQWN----SPQELFQRCKGYYFHFAGDSVPQHVQQWNVEKVELDKNKRFKDVEVVRYFWHSLEKELISRGYR---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: *. **:: : .::* :.. :* . : * :: *. .* . .: .* . . . :.* : . . . .:: :. : . :: * . . : ::: .: ... . *: * :* : :*:* . : :: : : : :: . . : :* * *: : . *: :* .* . :* * ::: . *: : ***:**:* :*::*: * *::* : ::: . :. : *:: .:: .: : ::*:. : : *:****:*. * ***:.: * .* ::* : .::: : : :*::*.* :.*. :**. * *. **.:*:: : . ", "identical_positions": 64, "similar_positions": 146, "identity": "11.59%" }, { "cls_id": "homologset.agr.HGNC:16784", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESN0-1", "uniprot_id": "NIBA1_RAT", "id": "Q9ESN0-1", "name": "Protein Niban 1", "aln": "MGGSASSQLDEGKCAYIRGKTEASIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPPLEPGTVLYEAELSQFAEDIRKWKDRYVVVKNDFAVESYENKEAYQRGAVPKSRILPAGGKVLTSEEEYSLLSDKHFPDPTASSEK-NSQPFLVLPKAFPVYLWQPYLRHGYFCFHEAAEQQKFSALLNDCIRHLN-HDYMKQTTFEAQAFLEAVQFFRQEKGHYGAWEVITGDEVQILSKLVMEELLPTLQTDLLPKLKGKKNDRKRAWFGLLEEAYNLVQHQVSEGLSALKEECRALTKDLEGTIRSDMDQIVNSKNFLTGKIRAMVAQPAENRCGESVQPFLASILEELMGPVSSGFSEVRALFEKEVDELSQSFHTTQDGAQLKECLDQLMKLPLDSVKMEPCYTKVTLLPERLLDLQSRFRFPHVDLVVQRTQNYMQELMENAVFTFEQLLSPYLQGEASRTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALIQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENIYEEILYQILLDETLKVITEAAILKKHNLFEDNMALPSESVSSLTDLKTSMGSNQASPARGASAILPGAPGDEAPGSEVFQGPEEKQQQPGVPGSLAREESASISGSSPPSGEDGQVSVSGVDNSAGNPLSADNSAGPLSSHLSEAEAGEPPKDEETAHKRPESSAVPGSLRELKELLT--VTVFVESAPEIGNDTLNGTPVPQEDKKEEEEEEESKIHPEASGPAAIQQDSCEESEVREREAHPMPLEAEAPGVNLGTLPEGRGPTSQSTGEGLTENTSCLGPIEEPSEAQGPTEEVLLATVSTQDSTE-AGGEAVHSVTVTPQEDATLSSNPICPVENNEGPQVSEDQEVLGGNDSPALA---MDTEQINDAHVYECHWEVEDAPSADILDVHDCDVGSPG----EW-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UW53-1", "uniprot_id": "NIBA1_MOUSE", "id": "Q3UW53-1", "name": "Protein Niban 1", "aln": "MGGSASSQLDEGKCAYIRGKTEASIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPPLEPGTVLYEAELSQFAEDIRKWKDRYIVIKNDFAVESYESKEAYQRGAVPKSRILPAGGKVLTSEEEYSLLSDKHFPDPTASSEK-NSQPFVLLPKAFPVYLWQPYLRHGYFCFHEAAEQQKFSALLNDCIRHLN-HDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMTTGDEVQVLSKLVMEELLPTLQTDLLPKLKGKKNDRKRAWFGLLEEAYNLVQHQVSEGLNALKEECRALTKDLEGTIRSDMDQIVTSKNFLTGKIRAMVAQPAEQCCGESVQPFLASILEELMGPVSSGFSEVRALFEKEVDELSQSFHATQDSAQLKEGLQQLMKLPLDSVKMEPCYTKVTLLPERLLDLQSRFRFPHVDLVVQRTQNYMQELMENAVFTFEQLLSPYLQGEASRIPVAIEKVKLRVLKQYDYDSSTIRKKIFQEALIQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILYEILLDETLKVITEAAILKKHNLFEDNMALPSESVSSLTDLKTAMGSNQASPARRVSAILPGAPDNELPSNEVFQEPEEKKEQPGVPGSLA------ISASSCPSGGDGQVSV---DHSAGGPLTVENTAGPLSSHLSEVEAGGTLKDEEPTCQSPEPSAVPGSLKELKKLLT--VTVSVESAPVVENDIHNGTPVPQENIKEEE----SKIHPEASHPAAIQQDSCEEREVREKEAQ--PLEAEAPGVDLGILPEGRGSTSQSTSGGLTENTSCPGPIEEPFEAQEPAEKVLPAIVSTEDSPQ-AGGEAEHSVTVTPQEDATLSSNPICPMESNEVAQASGDQEVLGGEDSSALG---MDTEQVNDTHEHACQWLVEDTLSTDILAVHDFDVSSPEQPSEEW-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZQ8-1", "uniprot_id": "NIBA1_HUMAN", "id": "Q9BZQ8-1", "name": "Protein Niban 1", "aln": "MGGSASSQLDEGKCAYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRTEVEQQRDLTSQFLKTKPPLAPGTILYEAELSQFSEDIKKWKERYVVVKNDYAVESYENKEAYQRGAAPKCRILPAGGKVLTSEDEYNLLSDRHFPDPLASSEKENTQPFVVLPKEFPVYLWQPFFRHGYFCFHEAADQKRFSALLSDCVRHLN-HDYMKQMTFEAQAFLEAVQFFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKGKKNDRKRTWLGLLEEAYTLVQHQVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNYLIGKIKAMVAQPAEKSCLESVQPFLASILEELMGPVSSGFSEVRVLFEKEVNEVSQNFQTTKDSVQLKEHLDRLMNLPLHSVKMEPCYTKVNLLHERLQDLKSRFRFPHIDLVVQRTQNYMQELMENAVFTFEQLLSPHLQGEASKTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALVQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILHQILLDETLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKPPTGSNQASPARRASAILPGVLGSETLSNEVFQESEEEK-QPEVPSSLAKGESLSLPGPSPPPDGTEQVIISRVDDPVVNPVATEDTAGLPGTCSSELEFGGTLEDEEPAQEEPEPITASGSLKALRKLLTASVEVPVDSAPVMEEDTNGESHVPQENEEEEE--------KEPSQAAAIHPDNCEESEVSEREAQ--PPCPEAHGEELGGFPEVGSPASPPASGGLTE------------EPLGPMEGELPGEACTLTAHEGRGGKCTEEGDASQQEGCTLGSDPICLSES----QVSEEQEEMGGQSSAAQATASVNAEEIKVARIHECQWVVEDAPNPDVLLSHKDDVKEGEGGQESFPELPSEE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FC82-1", "uniprot_id": "E7FC82_DANRE", "id": "E7FC82-1", "name": "", "aln": "MGASSSSLLDESKINYIRGRTEAELKNFSPHYRRQSCVAFFCHLKDEVEQHRAAQSQLLKQKVPPEASEVLYKDSMLYFDDN-RKWRERLVVVRADYSLELHDSQESYTKGTPARHKLLPTGGAVLTSEEKYTAVVDKDFPDPNGCKEE-ASVAMVVVPGPLPVYLRLPYRRDSYFCFHQEEKRARFVSILNDCIRHHN-QDFVKSTAHEVQAFLKAIHFYRQEKGHYESWDMLVGTDTQVLANLVLEDLLPSLQTELLPKLKGKKPERKRVWFATVEATYELVHEQLREGLESLKTECINASKQQEALIRSDMDQIINSQTFVETKLQALVSDPAMKYCSESVSPYLTSILEELMGPVSAGFQAVRQLLEDELTRICKDFPQGGVTEELQTALQQVGRD-----RMEDCYQHVNVLKEQLQELRNRFKFSNSSRVVHCTQGQMQQLMENAVYTFELLLQSALKDKPDKQASVMEKAKLRVLKQFDYDSSTVRKKIFQEALVDITLPAIKRSLAPACKTELQNFEQFVFADYTNFVQVENIYENILLNLLNNEVNKVVKEAASLKKNNLFADSTDLQCVSQSSLADSRTPPLSAPSSPPPVQASVTP----SRQPELMIHQISQQTTVIPVLK----------ITPETP---------------QADLPPTLLNSSSSLIPEVSSSEPANVSPAEESSSSQPE--STSSKVKDEDGSVS-------SDRAVYLNSTNTESPVPFVDASENG-------------------NVEEEASSSQSETK----CVQPDGPVEETVEKIVSVEAAPSSE-------------------EDGNDTQVSPVSPLDCDVPVGGAVALAADVVEK--CSVSADP--------------EEESADG------------VQSIRDLIMEVIEVEETVRPCAENLP-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B7L2-1", "uniprot_id": "A0A8M2B7L2_DANRE", "id": "A0A8M2B7L2-1", "name": "", "aln": "-MGASSSLLDETQSNYIKEQVDEKLKDFTPIYRKQYSVAYCSQIKDELEQRKEEHTQFLKQRPPPEAGKILFEEIVWYFDDG-RKWKERFIVIRACYVLEVHESYKSFLKGTPPQQRLIPTGGTILTAEDEYMELIDQCCPCTKNDRED-FAPPMVDMPGQFPVYLRLPYRQDSYFCFKDEDAQADFISLLADCVRHQNKADYLKKKTCEVKAFLKAFQLYREEKGQYESWDMLIGSDVRGLANLFMEDLMPYLEKELK----SKRTDKRKVWFATVESAYFLLQEHLFDRMTTLKEECKNKAKQQEALMRSDMDQITNSRTYLEGKLQALVSEPATKYCAEQVQPHLPALLEEVMGPISLGFTEARDLSEGMMEQLCEDFQDPQQEVELRQALFKMSKAN-----LQSCYEKVSGLKDHVQELQQTFNYS-IKGLVDSTEIYLKQLMENVEYSFELLVKKALLDPSVNFSEAMQKASDRVLKQFDYDSSTVRKRIIQEALVNITFPNIKKHLDPSFKEELPKFEQYIFADYSNFISVENVYEDIIQQILEKDVSTVVKEAASRKKFNLITESKYKFS--VSSLSSTPPGSAPSSPSRLNTSPSQRSPLPPSPLLTNGLTANRSVTVHSPNSENSTPMGRIDEGEYKTPIEGCSDDVFFTSETSTETKPELRTTTNAKEPSVSSSPVIVITEAKESPSSSAKAGDGSLSDLANKPTVIISPICKNTAGMEKLREVMESDDPALTKAKICDES------------------THPISVCLSIEDAEVGEVHKKMTGKQIMDLPEKAPKSCS--------------------------SPYLEDKTRPLDCVKEIRDLVVEVIEIEDTIKPNEDNND--------------------------------DDDDVDDDEDIQRFQELEATI-----------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .::** *** : **: :.: :*:*:* * :* .**: ::: *:**:: :*:** : * .. :*:: : * :. :**::* :*:: : :* ::. ::: :*: .: :::*:** :**:*::* : *: * . *. : .:: :* :**** *: :..****:: : * ::* **:** * *::*. : *.:***:*.:::*:***:* :*:: * : : *::*.:*:*:* *:.:* .*: ::::.*:. :* :* *::.:: : : :** ** :* *. :******* .*:.:: *::*:*::** : * *.*.*.*.::***:***:* ** .* * * : .:.:.* :*: * :: . :: ** :*. * ::: :*:. *.:. . :*. *: :::****. ::** *:. * . . . . .::*.. *****:******:**:*:****::**:* ::: * .: * ** ::**::***::*:: ***:**:*: ::* .:. .*:.*** ** **: :. . ***:. . . .* .: . . : . * : * : . . *. *..: . ..: : . : . : . ::. : * . : . . . . . . . . : :.: ", "identical_positions": 193, "similar_positions": 273, "identity": "20.19%" }, { "cls_id": "homologset.agr.HGNC:16785", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZHR0-1", "uniprot_id": "D3ZHR0_RAT", "id": "D3ZHR0-1", "name": "Transcriptional protein SWT1", "aln": "---MLLCTTSAHKLETVYDHKFPKMSIKESCGKEEKSQKK-QTTSSPTFDEDKKEGE-------------ISAGSTSSEHCVKPVSTKKRKLKPDDTDIVYYNTNRKHSMKRLNVEVGLPKKRPKFSSSTQ------VASYLNSNQITLHSSSSDGAK-------DTKLKDCKLTNIGSKLDYEIKSRSL----------------IKITKDMKSKAEDQTKE--KNWPSLLIQK-KMKELKKEKNN--KDSSE---------ELEKCTKNQPPQNYNFSNIIKEPLESGRKKIS---FKIPKKSSSALQKLAEENIFSVDSSKSKSKQEGKEHLQSHRVS------LSLERHKTENLFSESTHKHTVCER------RREYHLEHQETNGSDSKENCAQSFETPCSSVSSETIQDTDEEMQIVEELHAARVGKSVDLPAGPPSGELMSMEIDLVEDDVHSSADILSNTASDKKLLIVIDTNILMNHLKFVRILKTTEIPGFDTLVLIIPWVVMQELDRMK-AGKLLKHVQHKAVPAIHFINDSLKSQDRKLWGQSLQLASQKLYGLSDEN-------NDDRVLKCCLQYQELFPCSLVILCTDDRNLRSKGLISGVKSLSKEELDTEILNLTLNTDLCHQPYISKQ-QLKAEVPPTEETSKEESTNSGLSILLER-----IICDLEKCLGTALSSILETEMKIAFGNLWMEVLYLKPPWTLIN-LLQCFKKHWLAVFGLVMENNLLVTIESLYDNLSKANKAVDFTTVKFLLQDSKSLLHAFSTRSNYDGILPQTFAQVNKLLQVLAEVKTKLKPNSSESTMSKKQEDT-LMKLHNQEVTVFLDSHPPQFTRHQEIWSVLENVWTSIYQNSTDVFQTLDSSSTLTTSKIAS----FEEAFIYLQKLMVAVKDILEGIQRILAPNSNCQDVETLYNFLIKYEVN-KNVRFTAQELYDCVSQTEYREKLTIGCRQLIEMEYTMQQCSASVYMEAASRGWCEGMLNSRT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DBQ9-1", "uniprot_id": "SWT1_MOUSE", "id": "Q9DBQ9-1", "name": "Transcriptional protein SWT1", "aln": "---MLLCTTSAHKLETVYDHKFLKMSIKESCAKEEKSQKK-QTISSPTFNEDKKKGE-------------ISAGSTSSEHGVQPVSTKKRKLKADDTDNVYYNANRKNS-KRLNVEVFIPKKRLKFSSSTQ------AVSYLNNNQMTSHSCSSNGTK-------DTKVKDCKLTNIGSKLNYEIKNHSR----------------IKITKDMKSKPVDQTKE--KNWPSLLIQK-KMKELKKEKNN--KDSSE---------ELEKCKKNHLPQNYNFSNMIKESFESGRKKIS---FKIPKKSSTTLQKLVEEKIFTIDSSKSKSKQEEKQHLQSHQMS------LNLARHKTENSFSDSTHKQSVCER------IRKDHCEHQGTSSSDSKENHAQSFETPCSSVSSEDTQDADEEMQIVEELHAARVGRSVDLPVVPPSGELMSMEIDLVDEDAHPSA---AHTASDTKLLIVMDTNVLMNHLKFVKILKTTEIPGFDTLVLIIPWVVIQELDRMK-AGKLLKHVQHKAVPAIHFINNSLKSQDRKLWGQSLQLASQKLYGLSDEN-------NDDRVLKCCLQYQQLFPCSLVILCTDDRNLRTKGLISGVKSLSKEDLDTEILNLTLNTDLCHQPCISKQ-QLNAEVPPAKETPKEGAANSGLSILLER-----IICDLEKCLGTALSSILETEMKIAFGNLWMEVLYLKPPWTLIN-LLQCFKKHWLAVFGLVMENNLLVTVESLYENLCKANKAVDFTTVKFLLQDSKSLLHAFSTRSNYDGVLPQTFAQVNKLLQVLAEVKTKLKPSSSESTRSKEQEDTSLVKLHNQDVNVFLDSNLPQATRHQEIWSVLESVWMSIYQNSTDVFQTLDSSSTLTTSKIAS----FEEAFVYLQKLMVAVKDILEGIQRILAPNSNYQDVETLYNFLIKYEVN-KNVKFTARELYDCVSQTEYRERLTIGCRQLIEMECTMQQCSASVYMEARSRGWCEDMLNNRP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5T5J6-1", "uniprot_id": "SWT1_HUMAN", "id": "Q5T5J6-1", "name": "Transcriptional protein SWT1", "aln": "------------------------MSSKESCGKKETSQRKDTTTSSPNFGEKDKKER-------------KTPASSTSSSSIRSVSSEKRKLKSDHTDVLYYNIKRRQGLKRLSVEIDTLRRRPKIGSSSQRPIKLKEASYSNDNQIILQSPSSNGTKKDIHKCVDFKPKDIKLTNAGSKLDHGIKSLSS----------------PKIASDVKPKAEGQASE--NKWSHLLVQREKMKELKKGRNSKFRDNSEK-------CVLEKWKRNQFSQDYNSNKIIKEPLGSRRQKIS---FKIPIKSRDTLQKLVEENVFNIDSNNSKTKQEEREYLESSQVS------LNVTRQKTEHLLSDFTYKRTVHEW------KRKHHYDHQESNDSHSRENLTQSFEAPCCSVSSESIQDADQEMQIVEELHAARVGKSVDLP-----GELMSMEIDL-EDDVHSSS---ANNTSDRKLLIVIDTNILMNHLKFVRILKTTEVPGFDKLVLIIPWVVMQELDRMK-EGKLLKRAQHKAIPAVHFINDSLKNQDRKLWGQSIQLASQKHYGLSDEN-------NDDRVLKCCLQHQELFPCSFVILCTDDRNLRNKGLISGVKSLSKEELSAELLHLSLNTDVCHQPCIPKQ-QLKAETTPLKESYKEESTNSGLSILLES-----IVSDLEKSLGTGLSSILETEMKIAFGNLWMEILYLKPPWTLLH-LLQCFKKHWLAVFGLVMEKNLLLTIESLYKNLRKANKAVDFTTVKFLLQDSRSLLHAFSTRSNYDGILPQTFAQVNNLLQTFAEVKTKLKPNSSENTVTKKQEGTSLKNSHNQEITVFSSSHLPQPSRHQEIWSILESVWITIYQNSTDVFQRLGSNSALTTSNIAS----FEEAFICLQKLMAAVRDILEGIQRILAPNSNYQDVETLYNFLIKYEVN-KNVKFTAQEIYDCVSQTEYREKLTIGCRQLVEMEYTMQQCNASVYMEAKNRGWCEDMLNYRI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P2Z5-1", "uniprot_id": "A0A8M9P2Z5_DANRE", "id": "A0A8M9P2Z5-1", "name": "Transcriptional protein SWT1", "aln": "MASKKSKKKKNKKEEKLSSRLYEDEKEERDTKRCISSKSKHKHHHCVSFDKDEAKGRRATVSLPEKTFEAILNQTDAGESKSKKKRSKINKNKGTEKSKPVLNLPNKHEKKCVNAKDKHKNASPQISKNKAKNQPSSEEASKKREKLVSRKPPSEDLRWTLAKDDCLKLQQRRMKPVKRRLSQELHAQPKRRNIKNGTDVAQTNCQFKSPTEMRKKLVGKRSKKINQPAGAILQNSPGKTMKNNSKAAMSAVKHVRSKLKLLEDISPKKKDRAKQRKTLGVLLGEKSPSFCGSIANTKFKIP-KLPSAVKAQTNTNLFNVNSSDSRTQITTQPSLPGSSPAKPQNFLLRQQMQKPEEVSSQTSYELSSLCSSHHSYVSRQVQLVYTDDKGEVTMTDGASHNDQHISSQKAPKTYDFDHEVHLVEELNLARSERRLEVNVEQNCGELTCMDIDPPEEGANTIL-------KKQALLIVLDTNVLLSHLEFVKKIRSRGFGGLGFPTLLIPWVVLQELDYLK-SGKLSSKVEDKARPAVHYIYSCLKNQEPRLIGQSMQLASQADCGPGVVN-------NDDRVLQCCLQYQALYPEGALVLCTNDKNLCSKALLSGVKAYSKADLVIEAEGTTSKIFEPDQQYICARPAVMSPAGPVEKAEKQGSQDNSNSIVVDEQDLIEYVSLLESSLQAALSEVLTEEMKAAYGDLWIEIVYVKPPWSLEG-LLKCFKKHWIAVFGLIINRSLLSCVEMLSDCLCSD-RSVEHTSILSAVSLAKELLSALSGRSQYSGHVAHALSTLHTLQQRLQSPKALLESGEADNE-------------DSLMAEIEDDVALPPSTSHQEVWALFESIWNNVCQISSSLFSALHYTPGTTEPSLRSTSPPPQEALSCLQRLSTALKQLLEALQRLLSADSSVQDAQSLLSFIQTSEIAAMEPRFTAKSLFDCVSQQEYREKLCVGGAQLSELCVNLDQCAAAARSWP--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7KUW4-1", "uniprot_id": "Q7KUW4_DROME", "id": "Q7KUW4-1", "name": "", "aln": "-------------------------------------------------------------------------MSLGGESKHTPKSSNLRPLDDDQLVRIISTPRPSNGVSQHPAQDRLKRLQGQLKRVQD-----NEKEQGTTKRITHSSSASRRSS-------ASTSTPQRLLKFPPKVAMNAWEKPK------------------ALVDAN----------------------------------------------------RLKAGRTQTAYQRLMLLRASLQQK---------QLYEERNNNIVAKINEEVIEKQPEACN--ITNPSAFDGSTAS----------DMEVEPMEWQESIEEEAAQN----------DQDEAKKGDDTLLMLPAESIEEEAPQKGQDEAKEEDDTILMLQAADAEELPPRLEDY-----------------------------------MYFVLDTNVLIHNHKFVERLTDVVLPGTVGSMLYLPYIVIKELDKLK-SKYQSDCLQR--VIAMRAIRFLNTKFDESFQIQAQSALEEADHLIKIDC-------PDDSILNCCLQLQAQVPH--MILLTNDANLRLKANASNIQVSCRSDLMSTYVDEFAGFGD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12104-1", "uniprot_id": "SWT1_YEAST", "id": "Q12104-1", "name": "Transcriptional protein SWT1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDEKRAFPK-------------------------------------------------------------------------------GNNHIRSETFNGSVSHKISES------------IKDIASLRPHGKYTVQDIDNIIASTSSHENRGQSGDSNG---------------CINHDEEGDIP--------------MCDLNDESDVEMISEYLSSQREMEAQSVANYMPKINDDLPLLNPPTLKT--------------------------------------------AFVVDTNFIISHLNTLEKLRS--LSSTYHHLIIVPTTVIQELDGLKKSPDIARDNDDTTNQEHDRTIGTLARWGNDWIYKNLANLDSGLIGQKLKQSLNPGSLKDDSILDCCLYFKEILNC-FVILLSNDKNLCTKALTEDILTVSFRKNMDAKIIAMRAYEENQLRFANLRDSTVNNFDQNVTSYAHIPGIETPPLQFDK-----VSQNVFEQVKETIFFAIDHTLRKEYGEDIGFIDYNPDKLTTIENASNYIYLFWVSVFSELFTCSKIKKNEWKSLPTVLKSKPTNLNDLRTFEQFWETVLHFLFSKFTNE--------EKQSLEKQIHEWKTSINAIST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . .. : . : : : : : . . . : . . . . . :. : ::: :*:***.:: : : :. : . . : :* *::*** :* : : .. ** :*.*** : ::* ::* ** *. ..: . . ", "identical_positions": 21, "similar_positions": 60, "identity": "2.09%" }, { "cls_id": "homologset.agr.HGNC:16787", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AKY3-1", "uniprot_id": "A0A8I6AKY3_RAT", "id": "A0A8I6AKY3-1", "name": "alpha-1,2-Mannosidase", "aln": "MSEAGGGRGCGCRVPQRASWSLVAAT--AALYLMLATTVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATVFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRN-ISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD---GRVQLVQHAIQAASSVDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFG-RVVLTAGPAQFGLDLSKHK-ETRGFVASSKPYNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRAAILKGKRIPSYIINSNPEVENEDQPSSENDSQNQSAEQMLPLPQTVGLADQESPG-NPLESPSEPPSPADSEEAAGFAPSEQISSPTETQETAGLDGECTDLDNQLQDQPETEEDPSPNVSWGTKAQPMDSILADWNEDIEAFEMMEKDEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q2HXL6-1", "uniprot_id": "EDEM3_MOUSE", "id": "Q2HXL6-1", "name": "ER degradation-enhancing alpha-mannosidase-like protein 3", "aln": "MSKAGGCRGCGCRVPQRASWSLVAAT--AALCLVLATSVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEHMQWYNDELLHMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRS-ISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD---GRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFG-RVVLTAGPAQFGLDLSKHK-ETRGFVASSKPYNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDR----------------DPEMENEDQPSSENDSQNQSAEQMLSLSQTVDLADKESPE-HPADSHSEA-SPSDSEEAAGFAPSEQISGSTENHETTSLDGECTDLDNQVQEQSETEEDSSPNVSWGTKAQPIDSILADWNEDIEAFEMMEKDEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZQ6-1", "uniprot_id": "EDEM3_HUMAN", "id": "Q9BZQ6-1", "name": "ER degradation-enhancing alpha-mannosidase-like protein 3", "aln": "MSEAGG-RGCGSPVPQRARWRLVAAT--AAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQS-ISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD---GRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFG-RVVLTAGPAQFGLDLSKHK-ETRGFVASSKPSNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREYEEVEVLLSDKAKDR----------------DPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BEF7-1", "uniprot_id": "A0A8M2BEF7_DANRE", "id": "A0A8M2BEF7-1", "name": "alpha-1,2-Mannosidase", "aln": "------------------MWMLHSATMLPAFWLLFFMGTCIRLSETMSRDEKSKLRIQVLEMFDHAYRNYMDHAYPADELMPLTCRGRVRGLEPSRGDVDDALGKFSLTLIDTLDTLALLNKTVEFEEAVRRVVKDVRLDNDIVVSVFETNIRVLGGLLGGHSMAVMLKENG-QMVWYQNELLHMAKDLGLRLLPAFNTSSGLPYPRVNLRHGVHGPETRTGTETETCTACAGTIILEFAALSRFTGDPTFEAHARRALDFLWEKRQRNSNLVGTTINIHSGEWVRRDSGVGAGIDSYYEYLMKAYILLGDDQLLLRFNTHYASIMKYISQPPLLLDVHIHKPLLPARTWMDSLLAFFPGLQVLKGDIRPAIETHEMLYQVTKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATRDPYYLEVGRTVLENLNRFARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLFLLFAEEEDLPFNVEDYVFTTEAHLLPLSLSTASNSPAPPVINSVVIEELDDLNFEWTCPNTRLLFP-DPAFPRNFREPIRSAVDKSCLRPIAHREPGMG---RPPLRAQDFMANNPEHLELLRRMGVSLIHLKD---GRVQLVQHATQAVSAVAAEDGMRFMQEMMELSSQQQKEQ-LPPRAVQIVSHPFFG-RVVLTAGPAQFGMDLSKSSSGVRGFVTVAEPYNGCSE-LSNGEIVAGRIALLQRGQCMFAEKARHVQKAGAIGGIVIDDNEGSSSDTAPLFQMAGDGRNTDDVTLPLLFLFHKEGNILLEALKEYKEVEVLLSDKARDR----------------EAIFKGKALPGALLDGTTDGAEEEDCSTEERDHS---------------SPAPSEPVDQSQVTTQEQTAGDSESVQPAEGLGSYVSVD--AGEEPPADEDSN--------NQSVDSLMADWQEDLEAFKQMEKDEL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VK27-1", "uniprot_id": "Q9VK27_DROME", "id": "Q9VK27-1", "name": "alpha-1,2-Mannosidase", "aln": "MSTTSSESFVRG---QRLMLIFLVAMCIVVACVLSTETTMPT--QNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKK--SRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQDLIINVDEFVFTTEAHLLPLSIAQLGNA----TFSFRQTDEHNVLDFMRTCPSSNRLFP------EKVRKPLRNFITGSCPRTTAGKR----------LSALDFQASNADHLRAVYDMGITMVSVGDRSQGKVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDWIALMAGPSHFSPELTGDQ-FVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGAAALIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSMEFGKLSAVMQRRKQPLRVR----------------------VMQMVEFKRWQLAKEQRQNQTASVAQKPEKEL---------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . :: . **..*: :* :. :** *** **::**********:*:** ** *****:** **:**:**:*:****.:*.. **:.**: *::**.:*.*::*********::****..* :* *:::. * **:.***.*:::** :*******::*:*:.*:**: *:: * :. . :********::********:** . ** *: *:* **: *:*.*:*:*..:*:*:*:***:***************:*:*:*****. * *** ** ::*:*:*: *:**** :*:* ::.:**:****:******.**::**::******** : *.*:*****.**::**.******** *******:** * :**:**:. ::.*::.*:*.**:**::*****.********.*:* :***:***:: :*: :::::::********** :: .. . * : :* ***.:. *** ...*:*::. : ** * . * * ** *.*.:**. : **:::: : * *:*:*.: :* * .* *::*****:**:. *. :* :** :. :.* ***::*. :*: . ..* * ::* ..*.* * * * . *:: : :**:* *..*** *:.** . ** *: ***.:* *:* *:***: **: :*::*:: * . : .::. :: : .: : : : .: .. : ", "identical_positions": 349, "similar_positions": 246, "identity": "36.43%" }, { "cls_id": "homologset.agr.HGNC:16788", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1H291-1", "uniprot_id": "B1H291_RAT", "id": "B1H291-1", "name": "Testicular spindle-associated protein SHCBP1L", "aln": "MESDPTTSEPEAAIGSDSSP--VEQAILVSLRDSASA---KGLMSPVRSVVASPRPVKGKA----ARRRLQLPPVSQAETG-------DEEPVPAVPENQEEAQPLPPICASPMRGMWRSEKVALYCDQVLQGSKAEDADEAMSKYLSEKLKVTDRWLGVWKSNPELFFEKYEEASIPFVGILVEVTCKPRQNLSSCFKVTVSVAEPFSSNIANIPRDLVDEVLGELEYSAPLLEVYPVEGQDADVRDIALALEVVRFFYDFLWRDWDDEENCENYTALIEERIN-LWCDIQDGTIPGPIAQR-FKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTDMVKNLSSDTLLQQHDDLNLALDSCYSGDIVVIFPGEYQASNLALLTDDITIKGVGKREEIMITS-EPSHDSFVVSKADSVKLMQLS--------LIQQGTVDGIVVVESGHLTLENCLLKCEG-----TGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNN-GYGVSILQPSEQFFIVAEAALN-KGAASGDKKDDKMLSKVMQTLNVEMNNNRIEANSKGDIRIVTG--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TTP0-1", "uniprot_id": "SHP1L_MOUSE", "id": "Q3TTP0-1", "name": "Testicular spindle-associated protein SHCBP1L", "aln": "MESDATTSEPKASVGSDSSP--AEQTVLATLRDSVAAP-TRGFMSPVRSVVASPRPVKGKA----ARRRLQLPPVTQAETC-------DEEPVPAVPEDQEEAQPLPPIYASPMRGMWRSEKVALYCDQVLQGSKAEDAEEAMSRYLLEKLKAKDRWLGVWKSNPELFFEKYEEASIPFVGILVEVTCKPRQNLSSCFKVTVSVAEPFSSNIANIPRDLVDEVLGELEYSAPLLEVYPVDGQDADVRDIALALEVVRFFYDFLWRDWDDEENCENYTALIEERIN-LWCDIQDGTIPGPIAQR-FKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTDMVKNLSSDTLLQQHNDLNLALDSCYSGDIVVIFPGEYQASNLALLTDDITIKGVGKREEIMITS-EPSHDSFVVSKADNVKLMQLS--------LIQQGTVDGIVVVESGHLTLENCLLKCEG-----TGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNN-GYGVSILQPSEQFFIVAEAALN-KGAASGDKKDDKMLSKVMQTLNVEMNNNRIEANLKGDIRIVTG--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZQ2-3", "uniprot_id": "SHP1L_HUMAN", "id": "Q9BZQ2-3", "name": "Testicular spindle-associated protein SHCBP1L", "aln": "MASGSKASVPADSFRTISPDRRGEKSASAVSGDTAAATTLKGTAIPVRSVVASPRPVKGKAGRETARLRLQRLPAAQAEDTGEAAAAAAEEPLLPVPEDEEEAQPLPPVCVSRMRGMWRDEKVSLYCDEVLQDCKAEDADEVMGKYLSEKLKLKDKWLGVWKTNPSVFFVKYEEASIPFVGILVEVTCEPYQDSSSRFKVTVSVAEPFSSNIANIPRDLVDEILEELEHSVPLLEVYPVEGQDTDIHVIALALEVVRFFYDFLWRDWDDEESCENYTALIEERIN-LWCDIQDGTIPGPIAQR-FKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKREFGKTITHIVAKMMTTEMIKDLSSDTLLQQHGDLDLALDNCYSGDTVIIFPGEYQAANLALLTDDIIIKGVGKREEIMITS-EPSRDSFVVSKADNVKLMHLS--------LIQQGTVDGIVVVESGHMTLENCILKCEG-----TGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNN--LRTSNSSKSTLGGVNMKVLPAPKLKMTNNHIYSNK-GYGVSILQPMEQFFIVAEEALN-KRASSGDKKDDKMLFKVMQNLNLEMNNNKIEANVKGDIRIVTS--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VIP0-1", "uniprot_id": "NESD_DROME", "id": "Q9VIP0-1", "name": "Protein nessun dorma", "aln": "MEVFT-----------------FEKSYLERLKEAEAVLSWEGAVMPASQVRSEWK---------------------------------SYVELKIEPAGWQAIWKIPRVICEDLK-LRYPTIVYGYVEQVIFD-------ELKAVFVVTAVQDSD--VHLPESNEVSLVELWPTVQQENAALNVDTTAECIDRLR---FFYTHVWMPWDKDYDDDRDWVQQHLQARIQLVCDLSKNRLPRPLALHMRTLLAEAKYIQQRLDYLELDLSDAESDDEAVELNDSVAEPARKQSKAGSANGCLNVSSLPVTDLMCLHLRMAIIRSEFEILENPEMRRAYSELQSNSLKRLRCSSGRTRQSEDLLVERNSISHVVTLP------GKLQQQLELLKLAQTLVK---PESKVQLSNTLQDVLSICQSNDDILLSPGEHTIKFLEHLNDNGSLRGLTQPEAILSPAADLSLLPVVCSSDEDSTLLVIDGDYTLSELVLDCRHVRRGILLRNGTLTMRGCRLLGDGSSSTQEGIVCMPGASVELKSCLIEN-FAVGVSMRPKSSAELGSVQFKTCKTGLELLEKSASVNLQGSKCSFENCALGILADGFVLGEQRTEKVLVLNKFSELQRYNEDNLLGNCSFYNCKKNVRVFNESGQLLAQRSHQQLLEDELGGENKENIQLV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . *:: :: :. .* *. .* :. : : * . : :* : . :: : * * ::*: . * . :: :: .* : : ::* :. : .. ..: *:.*.: : . . * *:..: : : :.: .:: * : .:: : : :: *:* * .* *. :: . * :. : : : *: * : : * : *: :*. : :* *:*. .* . :. : *. : :. * *. :.::: ** :: :: ::* .:: :* . *: .*. * *.* ::: ***: * *.*: ::*: : * *: .: : * ..* *. :. .*: :. ::: * :::..* :*:..* * :* *: :.**:: :... * . ..**.: * * * * ::: *:. ..*:. .* * : .. .. :::..: .:: * :*: .:: * * : : . **: ::: : * * . ::: :* : *: : ", "identical_positions": 88, "similar_positions": 218, "identity": "13.04%" }, { "cls_id": "homologset.agr.HGNC:16789", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BNJ3-1", "uniprot_id": "NMNA2_MOUSE", "id": "Q8BNJ3-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "aln": "-----------------------------MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTG-----------------RFIVIGGIVSPVHDS------------------------YGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQT-----TCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIG--------QPQHENTQPIYQNS---NVPTKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLG--TVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q0HA29-1", "uniprot_id": "NMNA2_RAT", "id": "Q0HA29-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "aln": "-----------------------------MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTG-----------------RFIVIGGIVSPVHDS------------------------YGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQT-----TCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIG--------QPQHENTQPIYQNS---NVPTKPTAAKILGKVGESLGRICCVRPPVERFTFVDENANLG--TVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADADRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BZQ4-1", "uniprot_id": "NMNA2_HUMAN", "id": "Q9BZQ4-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "aln": "-----------------------------MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTG-----------------RFIVIGGIVSPVHDS------------------------YGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQT-----TCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIG--------QPQNETPQPIYQNS---NVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLG--TVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PC93-1", "uniprot_id": "NMNA2_DANRE", "id": "Q6PC93-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "aln": "-----------------------------MTENTKTHVILLSCGSFNPITKGHIHMFEKAREYLHKTG-----------------RFIVIGGIVSPVHDS------------------------YGKPGLVPSRHRLTMCQLAVQSSDWIRVDPWECYQDTWQT-----TCSVLEHHRDLMKRVTGCILSNVNTPSTTPVIG--------QPQNE-TSAIYQN-----TVNKSVAIKFWGKMSESLGKICCVRPHMDRFTFVDENANLG--TAMRYEEIELRILLLCGSDLLESFCIPGLWNESDMEVIVGDFGIVVVPRDGADTERIMNHSSVLRKHKDNIIVVKDEIDHPMSIVSSTKSRLALQHGDGHVVDYLSQPVIDYILQSQLYINASG----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q06178-1", "uniprot_id": "NMA1_YEAST", "id": "Q06178-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1", "aln": "MDPTRAPDFKPPSADEELIPPPDPESKIPKSIPIIPYVLADANSSIDAPFNIKRKKKHPKHHHHHHHSRKEGNDKKHQHIPLNQDDFQPLSAEVSSEDDDADFRSKERYGSDSTTESETRGVQKYQIADLEEVPHGIVRQARTLEDYEFPSHRLSKKLLDPNKLPLVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHFNHEINIKRGGVATVTGEKIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYN---DISSTKVRLFIRR-AMSVQYLLPNSVIRYIQEHRLYVDQTEPVKQVLGNKE", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53204-1", "uniprot_id": "NMA2_YEAST", "id": "P53204-1", "name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "aln": "MDPTKAPDFKPPQPNEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTLSSRKKNANSS------NRMDHIPLNTSDFQPLSRDVSSEEESEGQSNGIDATLQDVTMTGNLGVLKSQIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEINIKRGGIMTVDGEKMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYN---DISSTKVRLFIRR-GMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .:*: .*::. : . :. : . * :. **. .:. .* * : :::. :: : *. : :*. :. * *: *. :. : *:* : *:. . *:. : .: : . *** . : . : * : * .: *:: ::*:**.*.**:**: * :* ::*:. *:*::* ::* * .:*. :: .:: ::: **:::*: * : :**** ** ::: * *.:.** ** : .**:: : ", "identical_positions": 57, "similar_positions": 106, "identity": "14.07%" }, { "cls_id": "homologset.agr.HGNC:16790", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z9Z7-1", "uniprot_id": "D3Z9Z7_RAT", "id": "D3Z9Z7-1", "name": "", "aln": "MAAR-RATVACALLLLSSALLRRGCPARFAAESESDEDGEETVAFPESPLQKPTVFVVVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEILREWLKNVQRLYHYVEWRPMD-EPESYPDEIGPKHWPSSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLMIAENKTILAPMLESRGLYSNFWCGITPQGFYKRTPDYLQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLSFYP-----------PHQDYTWTFDDIIVFAFSSRQAGIQMYLCNKEHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQ--FVSVVPKY-PDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKAWNIEMLPGYRDPYSSRPLTRGEIGCFLSHFSVWKEVIDRELEKTLVIEDDVRFEHQFKRKLMKLMDDIDKARLDWELIYIGRKRMQVKEPEKAVPNVVNLVEADYSYWTLGYVISLEGAQKLVGADPFGKMLPVDEFLPIMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHSWKSRKQGPIHSNAKNTEALPPPTSLDTVPSRDEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NVG7-1", "uniprot_id": "GT252_MOUSE", "id": "Q6NVG7-1", "name": "Procollagen galactosyltransferase 2", "aln": "MAAR-LATVACALFLLSSALLRLGCRARFAAEPDSDEDGEETVAFPESPPQKPTVFVVVLARNAAHTLPYFLGCLERLDYPKSRMAIWAATDHNVDNTTEILREWLKSVQRLYHYVEWRPMN-EPESYPDEIGPKHWPNSRFSHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLMIVENKTIVAPMLESRGLYSNFWCGITPQGFYKRTPDYLQIREWKRMGCFPVPMVHSTFLIDLRKEASDKLAFYP-----------PHQDYTWTFDDIIVFAFSSRQAGIQMYLCNKEHYGYLPIPLKPHQTLQEDVENLIHVQIEAMIDHPPMEPSQ--FVSVVPKY-PDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKAWNIEMLPGYRDPYSSRPLTRGEIGCFLSHFSVWKEVIDRELEKTLVIEDDVRFEHQFKRKLMKLMEDIDKAQLDWELIYIGRKRMQVKEPEKAVPNVVNLVEADYSYWTLGYAISLEGAQKLVGADPFGKMLPVDEFLPIMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHSWKSRKQGHIRSTAKNTEALPPPTSLDTVPSRDEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IYK4-1", "uniprot_id": "GT252_HUMAN", "id": "Q8IYK4-1", "name": "Procollagen galactosyltransferase 2", "aln": "MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRPMD-EPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDYVQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTFYP-----------PHQDYTWTFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQ--YVSVVPKY-PDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLMKLMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPFGKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHAWKSRKQSRIYSNAKNTEALPPPTSLDTVPSRDEL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A9C3Q0-1", "uniprot_id": "A9C3Q0_DANRE", "id": "A9C3Q0-1", "name": "", "aln": "-----MPAEGFVFAAVICAVMAQNCSGELMAHVQDPN------PVPESSLLKPKVMIAILARNSAHSLPYYLDCIDRLDYPKDRIAIWAATDHNVDNSTAMLREWLKNRQSRYHYVEWRPME-EPRSYTDEWGPKHWSSSRVSHVMKLRQAALKAARARWADYILYVDSDNLLTNPRVLNLLMAENLTLVAPMLDSRSLYSNFWCGITPQGYYKRTPDYQPIREWKRLGCFSVPMVHSTFLLDLRRSATLDMAFYP-----------PHPDYSWAFDDIMVFAFSAREAGVQMYVCNREHYGFLPVPLKAQQSVEDEEESFTHTITEAMIDHN-IKPSE--FLFTPSKP-QDKMSFDEIFLINLKRRFDRRERMLNTMAVLGLEATLVDAVDGKTLNTSQLQALGIEMMPGYKDPYSGRVLTRGEIGCFLSHHFTWKQVLERGLRHVLVLEDDVRFEPRFKRRLQTIMKDVEKTQLNWDLIYVGRKRMQVAQPEVSVEGVNNLVEADYSYWTLGYALSQQGAKKLLAAQPLGKMLPVDEFLPVMFNKHPNSAYMSHFDPRDLRAFSVEPLLLYPTHYTGEPGYFSDTETSTIWDDESVNTDWDRQYAQKTAQQAQIRSVAQNSVTGDTPAPASRAS-RDEL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6YUW4-1", "uniprot_id": "A0A8M6YUW4_DANRE", "id": "A0A8M6YUW4-1", "name": "", "aln": "-----MMDPRASGKLLLGLVMLESWIGFIYTHTDLEP------VLHETSLLNPKVAIAILARNSEHSLPYFLGCIERLDYPKDRISIWAATDHNTDNTTGMLREWIAGVEDLYHSVQLHTMEQEKSSYVDELGPKHWPETRFTHVMKLRQAALKSARAQWADYVLFTDSDNLLTNTQVLNQLISENRTLVAPMLDSRTLYSNFWCGMTSQGYYKRTPHYVPIRTWKRTGCHPVPMIHSTMLIDLRRRASELLAFYP-----------VHHHYLWALDDIMAFAFSARQTGVQMFICNREHYGYLPQPLQMKQTLEEEVESFSHTVTEALVDFK-METSQ--YLHIVSKP-KDTMAFNQVYLINLKRREDRRDRMLRSLEVLGIDVTLTDAVDGKAMNSTQLRTLGIEMLPGFKDPYSDRVLTKGEIGCFLSHYNIWKKVVELQQQQVLVLEDDVRFETNFKSRLNTIMEDVKRSGLQWDLIYVGRKRLQIKHPERWVEGVKNLVSPDYSYWTLGYALSLQGAKILLEAQPLSKMLPVDEFLPVMFNKHPKKEYMSHFQLRNLKAFSVQPLLLFPTHYTGEAGYFSDTETSSIWDDETVSTDWDRN---------RIR-------GGKTTTSVSESSPKDEL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IPK4-1", "uniprot_id": "GLT25_DROME", "id": "Q8IPK4-1", "name": "Glycosyltransferase 25 family member", "aln": "------MNKQVIFGLLLACILVC------ISGQDEED-------YQES----PTVLIALLVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDNSGDLYHSVSYEFKP-EEQSFVNGTSPYEWPASRFKHLIALKEEAFQYGRDIWADYVFFLDADVLLTSKDSLKVLTRLQLPIVAPMLISESLYSNFWCGMTEDYYYRRTDEYKEIYHVKKQGSFPVPMVHTAVLVNMNHRAVRNLTFDRNKLVELQKSRQQEPLYDGPADDIIVFAISANSSGIPLHICNDITFGYILQPLEPGDTLDHDVQQLVNLKSIMVNELGAVPPLLDYYKHLEKKPEKSKLSLDRIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLLEMGVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWVMMVRKQLKEVLILEDDIRFEPYFRQNAVRILNQARN-AAQYDLIYFGRKRLKE-ESEPAVENADNLVHAGYSYWTLGYVISLQGALKLLAAKPLDKLIPVDEFLPLMFDRHPNKTWTEAFPKRNLVAFSASPLLLYPIYYTGESGYISDTEDS---QQISVETSEEGEARLKSDREQVFDHEQEFKLNPELKLGESLSKSHQEL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : : *: *.* :.:*.** * ** :*. ::: ****.*::** **. *:: ::*:*: . ** *. . * *: : .* .*. :*. *:: *:: *:: .* *:**::: * * :**. *: : : .::**** *. ********:* . :*:** .* * *: *...***:*::.*:::.: * ::* . * . ***:.**:*:..:*: :.:** :*:: **: ::::.: :.: : : : : . : * ..:.::.:::****** :**::* . : ::. ***** :.: :* .:.::**:.*** * :* *********. * :: ...*::***:*** *: . ::.: . :::***.****:: ..* * .. *** ..********.:* :** *: *.*:.*::*******:*:::** : . : *:* ***..***::* :***:.**:**** * :: :* *. : : . ::**", "identical_positions": 184, "similar_positions": 200, "identity": "28.71%" }, { "cls_id": "homologset.agr.HGNC:16791", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R3W5-1", "uniprot_id": "SEN15_MOUSE", "id": "Q8R3W5-1", "name": "tRNA-splicing endonuclease subunit Sen15", "aln": "MEERSDSEPTPGCSGPGPAPVR---DGGGAHTWAPEDAWMGTHPKYLEMMELDIGDATQVYIAFLVYLDLMESKSWHEVNCVGIPELQLICLLGTEIEGEGLQTVVPTPISASLSHNRIREILKASRKLQGDPELPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2K1V3-1", "uniprot_id": "A0A0G2K1V3_RAT", "id": "A0A0G2K1V3-1", "name": "tRNA-splicing endonuclease subunit SEN15", "aln": "MEERSDSEPTPGCSGPGPGPVR---DGGAAHKWAPEDAWMGTHPKYLEMMELDIGDATQVYIAFLVYLDLMESKSWHEVNCVGIPELQLICLLGTEIEGEGVQTVVPTPISASLSHNRIREILKASRKLQGDPELPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WW01-1", "uniprot_id": "SEN15_HUMAN", "id": "Q8WW01-1", "name": "tRNA-splicing endonuclease subunit Sen15", "aln": "MEERGDSEPTPGCSGLGPGGVRGFGDGGGAPSWAPEDAWMGTHPKYLEMMELDIGDATQVYVAFLVYLDLMESKSWHEVNCVGLPELQLICLVGTEIEGEGLQTVVPTPITASLSHNRIREILKASRKLQGDPDLPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****.********** **. ** ***.* .*****************************:*********************:********:********:********:**********************:*************************************", "identical_positions": 155, "similar_positions": 10, "identity": "90.64%" }, { "cls_id": "homologset.agr.HGNC:16792", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ACJ3-1", "uniprot_id": "D4ACJ3_RAT", "id": "D4ACJ3-1", "name": "Nonsense-mediated mRNA decay factor", "aln": "MLLQIVIVGENVSFKSQMRTENLKSEEHLKSSNIRQAEVLKAEMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDELKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHSYSQDEQLCWTQLLALFMSFLGILCKCPLQNDSQE-SYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPREDDLSSTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSAIESHASDGSPGLKSVLSTGRSPSTSCDSGEKPVVTFKENIKPREVNRDQGRSFPPKEVRRD---CSKGVTVTQDDGQKDSSKRRAETKRCTLGKLQETGKQSVAVQVKSQTELRKTPVSEARKTPVTQTPSQTNNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQSTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGP---QQSQPP---SQPPLTSLPAQPTAQSTSQLQVQALAQQQQSPTKVIPALGKSPPHHSGFQQ--YQQADASKQLWNPPQVQSPLGKI---MPVKQPYYLQTQDPIKLFEP--SLQPPVIQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADN-RAVMAQQPNMDRRSKRSPGVFRPEQDPVPR-MPFEDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF---KSLLEKPSELMSHSSSFLSLTGFSVNQERYPNSSVFNEVYGKNLTASSKAELSPSVASSQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSAPFSNFGPIGTPDNRDRRPADRWKTDKPAMGGFGVDYLSATSSS----ENSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGAMNPPH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5RJH6-1", "uniprot_id": "SMG7_MOUSE", "id": "Q5RJH6-1", "name": "Nonsense-mediated mRNA decay factor SMG7", "aln": "--------------------MSLQSAQYLR-----QAEVLKAEMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDELKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHSYSQDEQLCWTQLLALFMSFLGILCKCPLQNDSQE-SNNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPREDDLSNTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVVESLATDGSPGLKSVLSTGRNPSNSCDSGEKPVVTFKENIKPREVN--QGRSFPPK-------------------------------------------------EVKSQTELRKTPVSEARKTPVTQTPSQTSNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQSTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGP---QQSQPP---SQPPLTSLPAQPTAQSTSQLQVQALAQQQQSPTKVIPALGKSPPHHSGFQQ--YQQADASKQLWNPPQVQSPLGKI---MPVKQSYYLQTQDPIKLFEP--SLQPPVIQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADN-RAVMAQQPNMDRRSKRSPGVFRPEQDPVPR-MPFEDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF---KSLLEKPSELMSHSSSFLSLTGFSVNQERYPNSSMFNEVYGKNLTTSSKAELNPSVAS-QETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSAPFSNFGPIGTPDNRDRRPADRWKTDKPAMGGFGVDYLSATSSS----ESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGAMNPPH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92540-1", "uniprot_id": "SMG7_HUMAN", "id": "Q92540-1", "name": "Nonsense-mediated mRNA decay factor SMG7", "aln": "--------------------MSLQSAQYLR-----QAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVRRD---YSKGITVTKNDGKKDNNKRKTETKKCTLEKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGP---QQSQPP---SQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQ--YQQADASKQLWNPPQVQGPLGKI---MPVKQPYYLQTQDPIKLFEP--SLQPPVMQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADN-RSVMAQQANIDRRGKRSPGVFRPEQDPVPR-MPFE-----------------------------------------------------KSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAP-QETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSS----ESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LVF3-1", "uniprot_id": "SMG7_DANRE", "id": "Q1LVF3-1", "name": "Nonsense-mediated mRNA decay factor SMG7", "aln": "--------------------MNL-CAQYLR-----QAEALKADMTDSKLGAAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWSVSDFIKAFIKFHGHVYLCKSLDKLNTLREKLEEQFQRLILQKAFSSQQLVHITVINLFELHHLRDLSNEADEHSYSSDEQISWIQLLGLFMSFLGVMLSRALLNKNREEIMGECPLPAIKVSLDWLRLRPTVFNESAMDKRQYIWPWLVSILNSFQPKEEDVSNASVIPLPEEFELQGFLALRPALRMLDFSKGHQGIVIGKESLLIHARHQRLISLGKWVADNQPRLIQCRMSDGLVLFITDIPEIVVEEP-QEKDTPVLQESSNGEQTPNESTHGLKSVLSAGKNQNSGLDGSERPVVTFKENIKPREQSREQNRNQNQRDTGKDRAGFNKGNGVQGKNEQKKEGKRKSEVKKNSHDKTTDAG-----KQVKTQTELRKTPVSEARKTPVTQTQTTCS-SQFIPIHHPGAFPPLPSRPGFPPPAYVIPPPVAFSMSPGFTFPTGVSVPAPFLQTASHPQSANPVQTGKPSHIPYSQQRPSGPVALNQGPPQPQQTQPPPPQTSQQALQQSVQLQLQQQQQQQQQQQQQQQQSPTKQSSQLGKSPPHHHSMQQSYMQVPEQPGQMWNQHQNQPGMQKMPMQMPVKQPFFMPTQDPMKLFEHPMSMQP---QQPSMDKKMK-FP---------EVKVQDFYWDPPYHMAGEGRSTMA-----DRMGKRQPGVFCSDQENMPRGPPYEDNKSSPLLPPDLLKTLADFEEEEELLFTKPHDFYQALAGPLNSAPGRNMFLPNQSRLDSGADVIGQSS---LLPRFSIQDNSYQNNSIFSEAYGKNMTPSSKPDAP---MMHQEPSLYSLFEGNPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHSHGSMPFSNFGPIGTPDSRDRRANDRWKAEKTGVSGFGLDYLPSASTSSVPETNSWHQG-APTSTWAAQDMPMEDSSTVLLDSFKSIWSSSMMQPGPSALEQLLMQQKQKQQRGHGNMNPPH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .* . ::*: ***.***:*******.***********************************************.***********************************************************: :*:*****.***********************************************************************************************:****.*****************.***:**..*********:**::****.******:******:******:***:::*:**.***:.* ***.*******:: . .* *..:* . ****:***:******* **:*:.:*:********:*:****:*:*:*:*. .. ****************::* **********. .**. : *:*****:***:**********. . * :****:***:::*:* : *:. :***:* *. . :.: *******:.:. ... * .*:**********.** . *.*. : :**:******************** : . ************************:***********..*:***:*****..***.::*. :.* **:** ************* .:**** **:*** :. . ..* *. .* * * ******** . ******** .:** * .: . *:** * * : *: *****.::: ****:**** *:** ** .::**** ** **** :****..* **.: *:.** ** .**.**** .:*: :** *:* :* *:. ::::.:** *. **:::: * *.*:*.*.****:*.***.: **.********.***********************************.*.* ************.****. ****::*..:.***:***.::*:* .****. :*:.**:.:. .*****:**::*:*********:********************:* *****", "identical_positions": 750, "similar_positions": 214, "identity": "60.58%" }, { "cls_id": "homologset.agr.HGNC:16793", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6B330-1", "uniprot_id": "A0A8I6B330_RAT", "id": "A0A8I6B330-1", "name": "", "aln": "MEGGVQAPSLAGRPSRVAVILTEGQASYKVPDNCWSYSVGDRHFRESLSGILCGAAQNPHGFSQLRSHLLLMAGMAENTAAEHPLFTGASCVLVFLSCLGSTLCADVHSLSCNLIIRSPTKAEPLWYEGQCSMDGNVFLSSN-NVNKTMPLGNQEKMANATEVWTCLTQWID-RCKQDLRDKVSEIKGDTTKTSGHPTLRVTMLSNHSHEQIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDKTLMKHLN-LFIVECSPKFNEFLNQHEERTRSTTRAPDITQPPPTSQVP------YKEVLIPVGLIISIIFIIFLCICVKRMCCPHGGRELQLLKDYCINWHKPQRNEGLEETKGEVPNQRTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I6GMP0-1", "uniprot_id": "A0A8I6GMP0_RAT", "id": "A0A8I6GMP0-1", "name": "", "aln": "---------------------------------------------------MCPMAL----CSQFGTHLHVSL-------------------------------TDVHSFSCNLIIRAPTKAEPLWYEGQCSVDGIDFLSSN-NVNKTMPLGNQEKMANATEVWTCEIQWLD-LLGQDLRDKVSEIKVHTTKTSGHPTLRVTMLSKHRHGQIISASWEFNISENYSFILDLKNMKW-----IPEDIMKEWKDDATLMKHLN-LFIVECSPKFNEFLNQHEERTRSTTRAPDITQPPPTRQFP------YKEVLIPV---VLIIFIIFICICVKRMCCPQGGRELQLLKDYCINFHKPQRNEGLEETRGEVPNQRTKILSQEEDPKTLGGPRRASDPVELELHMVLSTGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I5ZTU3-1", "uniprot_id": "A0A8I5ZTU3_RAT", "id": "A0A8I5ZTU3-1", "name": "", "aln": "----------------------------------------------------MTMAKRGTTKCNLSLSLGLLLLLN---------------------FLGTAMLEDVHSLSCNLIIRSPTKAEPLWYEGQCSMDGIDFLSFN-NVNKTMPLGNQEKMANATEVWTCVTQWID-LLGQDLRDKVSEIKGDTTKTSGHPTLWVTMLSNHSHRHIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDATLMKHLN-LSIAECSQKFNEFLNQHEERTRSRTRAPDIAQPPPTRQFP------YKEVLIPV---VLIIFIIFICICVKRMCCTQGGRELQLLKDYYINLHKPQRNEGLEETKGEVPNQSTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O08604-1", "uniprot_id": "RAE1C_MOUSE", "id": "O08604-1", "name": "Retinoic acid early-inducible protein 1-gamma", "aln": "----------------------------------------------------MAKAAVTKRHHFMIQKLLILLSYG-----------------------YTNGLDDAHSLRCNLTIKAPTPADPLWYEAKCLVDEILILHLS-NINKTMTSGDPGETANATEVGECLTQPVN-DLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWNDDGDLVQRLK-YFIPECRQKIDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVG----LIFISLLFAFAFAM--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9CZQ6-1", "uniprot_id": "RAE1E_MOUSE", "id": "Q9CZQ6-1", "name": "Retinoic acid early-inducible protein 1-epsilon", "aln": "----------------------------------------------------MAKAAVTKRHHFMIQKLLILLSYG-----------------------YTNGLDDAHSLRCNLTIKDPTSADLPWCDVKCSVDEITILHLN-NINKTMTSGDPGKMANAT--GKCLTQPLN-DLCQELRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLK-YFIPQCRQKIDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVG----LIFISLLFAFAFAM--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O08603-1", "uniprot_id": "RAE1B_MOUSE", "id": "O08603-1", "name": "Retinoic acid early-inducible protein 1-beta", "aln": "----------------------------------------------------MAKAAVTKRHHFMIQKLLILLSYG-----------------------YTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCFVGEILILHLS-NINKTMTSGDPGETANATEVKKCLTQPLK-NLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYPQSQGRTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKQLK-FLIHECSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVG----LIFISLLFAFAFAM--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JI58-1", "uniprot_id": "RAE1D_MOUSE", "id": "Q9JI58-1", "name": "Retinoic acid early-inducible protein 1-delta", "aln": "----------------------------------------------------MAKAAVTKRHHFMIQKLLILLSYG-----------------------YTNGLDDAHSLRCNLTIKAPTPAD----EVKCFVGEILILHLS-NINKTMTSGDPGETANATEVGECLTQPLK-DLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTEIMSWRSANDESGVIMNKWKDDGEFVKQLK-FLIHGCSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPTSHSTSKKGFISVG----LIFISLLFAFAFAM--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O08602-1", "uniprot_id": "RAE1A_MOUSE", "id": "O08602-1", "name": "Retinoic acid early-inducible protein 1-alpha", "aln": "----------------------------------------------------MAKAAVTKRHHFMIQKLLILLSYG-----------------------YTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCLVDEILILHLS-NINKTMTSGDPGETANATEVGECLTQPLK-DLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYLQSQGQIPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKRLK-FLIPECRQEVDEFLKQPKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVG----LIFISLLFAFAFAM--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6GGC1-1", "uniprot_id": "A0A8I6GGC1_RAT", "id": "A0A8I6GGC1-1", "name": "", "aln": "----------------------------------------------------MAKGATSKCNHSLTLSLLVLLNSLG-----------------------TMQVDGTDSLSCNFTVQYKVSLG------QCSVNGMTVLCFD-DVRQNSPVCKTEKKGNATKLCNDLNQCLSYSFYEMMKLESG-----LFESKGNHTLRVTVQSQYNQGEFMDGCWAFMIDRQYPFYFYPKNMTWRENQPNAIKTMSQWENNRELFQSLKFLSTGDFSLCLKKLLTDSRELTRSTIKAPDTTQPTSTTQSPSTGNSTPAMSSNQSPSTGNSTQPTSTTDYLIVFEFTAIFLALIVVSMEKKKVLPAAPLPLQYELQSPSPAVLEES--------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "B1B212-1", "uniprot_id": "H60B_MOUSE", "id": "B1B212-1", "name": "Histocompatibility antigen 60b", "aln": "----------------------------------------------------MAK-----SSLSLNWSLLVLLNFLG-----------------------ATLSTGTDSLSCELTFNHRTLHG------QCSVNGKTLLDFG-DKK---------HEGNATEMCADLSQSLR-ELSEGMRNQQ----------SGNDALNVTTQSQYNQGEFIGGFWAINTDEQHSIYFYPLNMTWRESHSDNSSAMEHWKN-KNLEKDIRNVLIIYFSRCLNKLSPHFREMPKSKIKVLDTTQNTNTTQIHPTVNNSQHNSDTQG--------LSFTWIVIICIGGIVSFMAFMVFAWCMLKKKKGA-------LCCSSSSTT-----------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TD07-1", "uniprot_id": "RAE1E_HUMAN", "id": "Q8TD07-1", "name": "Retinoic acid early transcript 1E", "aln": "----------------------------------------------------MRRISLTSSPVRLLLFLLLLLIAL-------------------------EIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLG-EVGRDLRMLLCDIKP-QIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLP-------DRWIILG---AFILLVLMGIVLICVWWQNGEWQAGLWPLRTS---------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : . .*: :: .. : :. .* . : . . ** * : . :: .. * * . .. : . . : : *.* . *:. : : :. . :: . . ... . :: : . ", "identical_positions": 11, "similar_positions": 52, "identity": "2.69%" }, { "cls_id": "homologset.agr.HGNC:16795", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08603-1", "uniprot_id": "RAE1B_MOUSE", "id": "O08603-1", "name": "Retinoic acid early-inducible protein 1-beta", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCFVGEILILHLSNINKTMTSGDP-GETANATEVKKCLTQPLKNLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYPQSQGRTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKQLKFL-IHECSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JI58-1", "uniprot_id": "RAE1D_MOUSE", "id": "Q9JI58-1", "name": "Retinoic acid early-inducible protein 1-delta", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKAPTPAD----EVKCFVGEILILHLSNINKTMTSGDP-GETANATEVGECLTQPLKDLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTEIMSWRSANDESGVIMNKWKDDGEFVKQLKFL-IHGCSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPTSHSTSKKGFISVGLIFIS--------------LLFAFAFAM--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O08602-1", "uniprot_id": "RAE1A_MOUSE", "id": "O08602-1", "name": "Retinoic acid early-inducible protein 1-alpha", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCLVDEILILHLSNINKTMTSGDP-GETANATEVGECLTQPLKDLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYLQSQGQIPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKRLKFL-IPECRQEVDEFLKQPKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9CZQ6-1", "uniprot_id": "RAE1E_MOUSE", "id": "Q9CZQ6-1", "name": "Retinoic acid early-inducible protein 1-epsilon", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTSADLPWCDVKCSVDEITILHLNNINKTMTSGDP-GKMANAT--GKCLTQPLNDLCQELRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLKYF-IPQCRQKIDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZTU3-1", "uniprot_id": "A0A8I5ZTU3_RAT", "id": "A0A8I5ZTU3-1", "name": "", "aln": "MTMAKRGTTKCNLSLSLGLLLLLNFLGTAMLEDVHSLSCNLIIRSPTKAEPLWYEGQCSMDGIDFLSFNNVNKTMPLGNQ-EKMANATEVWTCVTQWIDLLGQDLRDKVSEIKGDTTKTSGHPTLWVTMLSNHSHRHIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDATLMKHLNLS-IAECSQKFNEFLNQHEERTRSRTRAPDIAQPPPTRQFPYKEVLIPVVLIIFIIFICICVKRMCCTQGGRELQLLKDYYINLHKPQRNEGLEETKGEVPNQSTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6H3X3-1", "uniprot_id": "ULBP5_HUMAN", "id": "Q6H3X3-1", "name": "UL-16 binding protein 5", "aln": "----MAAAASPAFLLRLPLLLLLSSWCRTGLADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGSKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLLDIQLENYIPKEPLTLQARMSCEQKAEGHGSGSWQLSFDGQIFLLFDSENRMWTTVHPGARKMKEKWENDKDMTMSFHYISMGDCTGWLEDFLMGMDSTLEPSAGAPPTMSSGTAQPRATATTLILCCLLIMCLLICSR-HSLTQSHGHHPQSLQPPPHPPLLHPTWLLRRVLWSDSYQIAKRPLSGGHVTRVTLPIIGDDSHSLPCPLALYTINNGAARYSEPLQVSIS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..:. : **:**. * * *** :: : . : :. :* . .**:. . : *.* . . : : : * ::: : : :. .. * . * :. ..: :.:. . : : : * : . : ::*::* : :: : * .::** .. .. : :* . .: . :* :* * : ", "identical_positions": 27, "similar_positions": 77, "identity": "7.96%" }, { "cls_id": "homologset.agr.HGNC:16798", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08603-1", "uniprot_id": "RAE1B_MOUSE", "id": "O08603-1", "name": "Retinoic acid early-inducible protein 1-beta", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCFVGEILILHLSNINKTMTSGDP-GETANATEVKKCLTQPLKNLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYPQSQGRTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKQLKFL-IHECSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM-------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JI58-1", "uniprot_id": "RAE1D_MOUSE", "id": "Q9JI58-1", "name": "Retinoic acid early-inducible protein 1-delta", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKAPTPAD----EVKCFVGEILILHLSNINKTMTSGDP-GETANATEVGECLTQPLKDLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTEIMSWRSANDESGVIMNKWKDDGEFVKQLKFL-IHGCSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPTSHSTSKKGFISVGLIFIS--------------LLFAFAFAM-------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O08602-1", "uniprot_id": "RAE1A_MOUSE", "id": "O08602-1", "name": "Retinoic acid early-inducible protein 1-alpha", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCLVDEILILHLSNINKTMTSGDP-GETANATEVGECLTQPLKDLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYLQSQGQIPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKRLKFL-IPECRQEVDEFLKQPKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM-------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9CZQ6-1", "uniprot_id": "RAE1E_MOUSE", "id": "Q9CZQ6-1", "name": "Retinoic acid early-inducible protein 1-epsilon", "aln": "--MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTSADLPWCDVKCSVDEITILHLNNINKTMTSGDP-GKMANAT--GKCLTQPLNDLCQELRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLKYF-IPQCRQKIDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFIS--------------LLFAFAFAM-------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZTU3-1", "uniprot_id": "A0A8I5ZTU3_RAT", "id": "A0A8I5ZTU3-1", "name": "", "aln": "MTMAKRGTTKCNLSLSLGLLLLLNFLGTAMLEDVHSLSCNLIIRSPTKAEPLWYEGQCSMDGIDFLSFNNVNKTMPLGNQ-EKMANATEVWTCVTQWIDLLGQDLRDKVSEIKGDTTKTSGHPTLWVTMLSNHSHRHIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDATLMKHLNLS-IAECSQKFNEFLNQHEERTRSRTRAPDIAQPPPTRQFPYKEVLIPVVLIIFIIFICICVKRMCCTQGGRELQLLKDYYINLHKPQRNEGLEETKGEVPNQSTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5VY80-1", "uniprot_id": "ULBP6_HUMAN", "id": "Q5VY80-1", "name": "UL16-binding protein 6", "aln": "--MAAAAIP--ALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYISMGDCIGWLEDFLMGMDSTLEPSAGAP-LAMSSGTTQLR----ATATTLILCCLLIILP-----------------CFILPGI------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** . . : **:** :* *** :: : . : :. :* . ***:. . : *.* . . : : : * ::: : : :. ... * . * :. ..: *.*. . : : : * : . : ::*::* . :: : * .::** .. .. : :* :: . * : . :: :* : : : ", "identical_positions": 30, "similar_positions": 77, "identity": "9.2%" }, { "cls_id": "homologset.agr.HGNC:168", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R5C5-1", "uniprot_id": "ACTY_MOUSE", "id": "Q8R5C5-1", "name": "Beta-centractin", "aln": "---MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRK-EGADFHTSAEFEVVRTIKERACYLSINPQKDE-----ALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AKZ9-1", "uniprot_id": "A0A8I6AKZ9_RAT", "id": "A0A8I6AKZ9-1", "name": "Beta-centractin", "aln": "---MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRK-EGADFHTSAEFEVVRTIKERACYLSINPQKDE-----ALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P42025-1", "uniprot_id": "ACTY_HUMAN", "id": "P42025-1", "name": "Beta-centractin", "aln": "---MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRK-EGVDFHTSAEFEVVRTIKERACYLSINPQKDE-----ALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVVAFAIHKSDMDLRRTLFANIVLSGGSTLFKGFGDRLLSEVKKLAPKDIKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P45889-1", "uniprot_id": "ACTZ_DROME", "id": "P45889-1", "name": "Actin-related protein 1", "aln": "---MEPYDVVVNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPMEHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRR-EGFNFRSTAEFEIVRSIKEKVCYLATNPQKEE-----TVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPDLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIAAPQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38696-1", "uniprot_id": "ARP1_YEAST", "id": "P38696-1", "name": "Centractin", "aln": "MDQLSDSYALYNQPVVIDNGSGIIKAGFSGEERPKALEYCLVGNTKYDKVMLEGLQGDTFIGNNAQKLRGLLKLRYPIKHGVVEDWDSMELIWSYVLNEVLQLQNIGEHPLLITEAPMNPLKNREQMAQVLFETFDVSALYVSNPAVLSLYASGRTTGCVVDCGEGYCSTVPIYDGFALPASMMRMDIGGADITEQLQFQLRKSAGVSLFSSSEREIVRTMKEKVCYLAKNIKKEEEKYLQGTQDLISTFKLPDGRCIEVGNDRYRAPEILFSPQIIGLGYDGLSDMCMQSIWKVDLDLRKPLLSSIILSGGTTTLKGFGDRMLWDLEALTKGTSKIKIIAPSERKYTTWIGGSILTGLSTFQRLWTKKSDWLEDSTRVYSNLM-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. : ***********:*****:*:. ** :*..*: :** .*:** *:* :*:: ****.:***::**:* **:.** **.*: .: :**:*:****:** :***: *:.:** ::..**::* *******:**.** *:*.*:* :****:***:* *:**:**.* *::. *: :*: * .: :::* *:**::**:.***: * :*:* : :.**** :::* *:****:** *:::* :*: :: :* * *:***: * .*:****:* :******:* ::: : **:* **.** *:**:*****:.*.**:::* .* :: *:. :. . ", "identical_positions": 165, "similar_positions": 119, "identity": "42.86%" }, { "cls_id": "homologset.agr.HGNC:16800", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9PWP7-1", "uniprot_id": "E9PWP7_MOUSE", "id": "E9PWP7-1", "name": "", "aln": "MSTRRWVRQTAALCLLAFILHSLPRHIAAENGTTESGSVWDGGGNSTQDDSQE---TQFRTVLKTKTTDGENSEAWPRQEYQQRSSSPSTTKAEVTTTADVTTTADVTTTAEITTTSDVTTTAEITNTDDVTTTGEVTTTADVTTTSDVPTTSEVTSTDDVITTAEVTTTAEMTPTDDVTTTSEVTTTGDVTTTGDVTITGDLTTTADVTTKADFTTTDDVTTTADGSTTADLTTTAKVTTTDDVTTTGEITTTSEITTTSDVTTTAEITTTDIVTTTG---EVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTIAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETTTADITTTADLTTTAEITTTDDVTTTVEITTTSDVTTTTEITTTDIVTTTGEVTTTADVTTASDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTT-GEVTTTADVTTTSDVTTTSEETTTADVTTTSDVTTTAEITTTDDITSTADVTTTADVTTTSDVPTTSEETTTADVTTTSDVTTTAEITTTDDITSTADVTTTADVTTTSDVTTTTEENPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTDEDTTTADVTTTSDVTTTSEETPTADITTTADLTTTADVTTTSDVTTTSEETTTADVTTTSDVTTTAEITTTDDITSTADVTTTTNVTTTSDVPTTSEVTSTDDVITTTEVTTTAEIIPTDDVTTTSEVTTTGDVTTTGDVTMTGDLTTTADVTTTADLTTTDEVTTTADGSTTADLTTTAEVTTTDDVTTTVQITTTSEITTTSDVTTTAEITTTDNVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLNTTAEVTTTEDVTTTVEITTTSEITTTSDITTTAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTADITTTADLTTTAEITTTDDITSTADVTTTTDVTTTSDVPTTSEVTSTDDVITTTEVTTTAEIIPTDDVTTTSEVTTTGDVTTTGDVTMTGDLTTTADVTTTADLTTTDEVTTTADGSTTADLTTTAEVTTTDDVTTTVQITTTSEITTTSDVTTTAEITTTDNVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTEDVTTTVEITTTSEITTTSDITTTAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTADITTTADLTTTAEITTTDDVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEITTTDDVTTTGEVTTTADVTTTSDITTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDITTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEQTPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADITTTSDVTTTSEETTTADVTTTTDVTTTSEETTTGDGKTTTAEITTTDDITTTADVTTTPDVTTTAAVTTTGEITPTDDVTTTSEVTTTGDVTSTGDVTTTGEVTTTAEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDTTTTSEETPTADITTTVDLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTSDIFTTTGEVTTTADITTTSDVTTTSEETPTADITTTADLTTTAEITTTDDVTTTVEITTTSEITTTSEVTTTPDVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTVDVTTTNDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDITTTSEETPTADITTTVDLTTTVEIT----TTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTSGEVTTTADVTTTSDVTTTSEETTTADVTTTTDVTTTSEETTTGDGTTTTAEITTTDDLTTTADVTTTPDVTTTAAVTTTAEITPTDDVTTTSEVTTTGDVTTTGEVTTTAEVTTTDDVTTTGDVTTTGDLTTMADVTTTADFTTTDDVTTTADASTTADLATTAEVTTTDDVTTTVEITTTAEITTTAEVTTTDDVTTTGEVTTTADVTTTTDVTTTSEVTTTADVTTTNDVTTTAEITTTDDITTTADVTTTADVTTTSYVPTTSEVTSTDDVTTTAEVTTTAEITPTDDVTTTSEVTTTGDVTTTGDVTMTCDLTTSADVTTTADFTTTDDVTTKADGSTTADLTTTAEVTTNDDVTTTGELTTTAEITTTSDVTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETTTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTIAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADITTTSDVTTTSEETTTADVTTTTDVTTTSEETTTGDGKTTTAEITTTDDITTTADVTTTPDVTTTAAVTTTGEITPTDDVTTTSEVTTTGDVTTTGDVTTTGEVTTTAEVTTTDDVTTTGDVTTTGDLTTTADVTTTAYFTTTDDVTTTADGSTTADLTTTAEVTTTDDVTTTVEITTTAEITTTDDVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSD---VTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTAEITTTDDVTTTGEVTTTADVTTTAEVITTSDVTTTADVTTMPDFTTTAEVTTTLDVTTNDEVTTTSVVTTTPEITTAGDVTTTSEVTTSADLTTTPEITTTGDVTTTADVTTTADITTTSDVTTTADVTTTADITTTSDVTTTADVTTIADLSTTPEITTTGDFSSTTDVTSTGDVTTTADVTTTADVTTTGDVTTTAEVTTTAEVTTTAEATTTADLNTTPEITTTDDVTTTGDVTITAEVTTTAYVTTTTDFTTTAEVNTTDDVTTIADLTTTAEVTTTNDVTSTAEITTTADLTTTTEVTTTADFITTGDVTTTADVTTMADVTTTADVTTADLTTTVDVTTMDDVTTTAEVITSGDVTTTSEVTTTSNLNTTPEITTTIDFTSTVDVTTTGDVTTTADVTTTSDVTTTSKVTTTGDVTTTADTTSTADVTTTADVITTAEVTTTADFTNTGDVTTSADVTTTADLTTMPDLTTTAEVTTTADVTTTSEFTTTADVTTTADVTSTADVTTTAEVTTTGDVTTTADVTNTGDITTIGDVTTTTEITTTAYLTTTLEITTTGEVTSTADVTTSAEVTTTDEITTTDVVTTTGDVTPTAESTTTDDVTTTSDVTTTGDFTTTADVTTTAYVTTTPDVTTTVEVTTTADFTTTGVVNTTADVTTTADVTTTSEVTTTADLTTTPEITTTVDFTSTADVTTTADVITTPEVTTTSDVTTTAEVITTADVTTTADVTTTVEVTTTGDVTITADVTTTPEITTTVDFTSTADVTITADVTTTADVTTTSDVTITPDVTTTAEVTTTVEITTTDDVTTTGEVTTTADVTTTSDVTTTSEETTTADITTTSDVSTTSEVTT---TAYVTTTADTTSTAEVT--TTADVTTTADVTTTADVTTTADVTTTVEVTTTGDVTTTADVTTTAEVTTTAEITTTGDVTTTADVTTTAEVTTTAEITTTGDVTTTADVTTTADVTTTADVT-TTIDVTTTADVTTSAEVTTTADVTTTTEVTTTTEVATTPEPTTTPAPTTTAVNCMNGGFWTGDKCICPNGFGGDRCEN---IVNVVNCENGGTWDGLKCQCTSLFYGPRCEELVESVEIEP--TVAASVEVSVTVTSQEYSEKLQDRKSEEFSNFNKTFTKQMALIYAGIPEYEGVIIKNLSKGSIVVDYDVILKAKYTPGFENTLDTVVKNLETKIKNATEVQVQDVNNNCSALLCFNSTATKVQNSATVSVNPEETCKKEAGEDFAKFVTLGQKGDKWFCITPCSAGYSTSKNCSYGKCQLQRSGPQCLCLITDTHWYSGENCDWGIQKSLVYGLGGAGVAVLLVILVILLVFSIRFRKDAQRQRSRVSEMYKWGEEEGRASPGTFHNFGFDHNEERENYMPLDSVYNTFQPSLNHINPERKIQIQRPQVVMTSL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q685J3-1", "uniprot_id": "MUC17_HUMAN", "id": "Q685J3-1", "name": "Mucin-17", "aln": "----MPRPGTMALCLLTLVLSLLPPQAAAEQDLSVNRAVWDGGGCISQGDVLNRQCQQLSQHVRTGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMP-VSKTLLTSSEASTLSTTPLDTSTHITTSTEASCS-PTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTP-VTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEAS-SSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSS--------TTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSS---PTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTST-PVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAG-MPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTS--EGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTP-VVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSS-PVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISS---SATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTTCFGDGCQNTASRCKNGGTWDGLKCQCPNLYYGELCEEVVSSIDIGPPETISAQMELTVTVTSVKFTEELKNHSSQEFQEFKQTFTEQMNIVYSGIPEYVGVNITKLRLGSVVVEHDVLLRTKYTPEYKTVLDNATEVVKEKITKVTTQQIMIN-DICSDMMCFNTTGTQVQNITVTQYDPEEDCRKMA-KEYGDYFVVEYRDQKPYCISPCEPGFSVSKNCNLGKCQMSLSGPQCLCVTTETHWYSGETCNQGTQKSLVYGLVGAGVVLMLIILVALLMLVFRSKREVKRQKYRLSQLYKWQEEDSGPAPGTFQNIGFDICQD-DDSIHLESIYSNFQPSLRHIDPETKIRIQRPQVMTTSF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *****:::* ** : ***:. : . :****** :*.* : *: ::* :: . : : . : : * ..:*:.*:*: . .*: .:: *.:: **:* *. . . .... *:. **.... .. ...* :.: :* ..:** :.. : *: : . . **. : :. *. : . .*: : . *: .** :: * . * * : :* ::: :::. .: ..::.: : .:. :. :..:*:.:* * ..:::*.. :. :::. **::..: ... * .. . ** :: ::*::: * : . *: :.*** .:: *: * *: *: : *. *:* : :: :..*:* : :. :***:.*.:::. .: :.::*:: . :: :*: . **.. : :.:::** : .* . .:* :. :..: *..: .:*.*: :*. :.. :. ::. ::* ..*... ...: .: ::. :**.: *: . *.::. *. :::..:: :..:*:.:**: . :: .*:. :::. **::..: ... : * ** .:*: ::::: * : . : .*** :*:*. *. . .*: * : *: *.** :: *.. :*: * *:: :**: : :*:. .: :.:.*:: :: :** * .* .:: *. :.* : *::.:**: :.: : .* * . : : : * *: *: *. *. *. :*: * :.. ***:.:::::. : :.:.*:: :*: ** . .:: * ::**. :*.*. :*.::: .::. .: .:.*:. :: :*: .* **.. : : :::* *:*. .*:*: .::.: *: *:*.. **. :*. . * .*: ::* **. * *. .:: . ..* *: ...: :*. ... . .:.. * * . *.: *..: : :.. :*****:: . * : *. .*..:.::..:** :* * ... :.*..* .. :: . .***: *: . ..:. ** *.:..:: *..::*..* . ... : .::. ::* .*: : . .. ... *: . . *:::. .* ::. . *: .**: *::. .*: * .*: .: * : *: :.* :. *. *: : *.. *.*:.**:::. : :.:.*:: . : :*: . ** . :: . ::** .:*. .*:*. ::.: . *: .:... **. .: . ..*..*. ::: :*. *.:*.. :: :.* : .:*.*: .*. :. *.:: ..: . ::* ..*..*. :..* *:.*. .*.:: *: * *.:: *: .:..:: .::*::.: * .:.:....** ::*. **:.. . *: : . *: *:* *:: * . :* * .. :**:::*.::: .*: *. * : : : : *: *:**. :* *. :*: : :.: * *: :*::: .*.*: *: . :* *. .** :.**. . .::: ::* . ... . ..*:. : *. **: : .: .: * .. *: .:*: * ::. .* :* *: .**: :*:. .*: .** :: *:. *: * ..: :. .*: : :.: :.*:: *::: : ..*:*:: :: :*: . *** : *. ::** **:* *** :: :.:. : :.:.*:: :*: ***. : . ::** :* *. * : ::.. .*. : * *: ::** :*:: ... :*: * *:: .**::* :.:. : :.: *:: * :: : ::** ::: .:. :*: : :. **.* *.:::* . :* . ::..* :. .: . ..*..:. :: .**.. . :.. * .:. . ..: *: : * : . ** .:..:: *.::. ::* . ... :....*:.. : .. **: * .:*.:: :*. ..: ...:. *:* ..*..* *... * ::. .**** *: * : .*. :.:..: :.:.***:* : ... .:.. *:. ::. .*: ..: .:..:: . .* * .** *:: * :: : *. .** . : :. .*: . *. : .: *:. .:* *:::*. :*: : *:: ***. :.::: : :.*.*:. *: ::: : **. *:: *.. :*: * *:: **::: :::. : *. : :. :*: . **. . : ::** : :.: **:* :::... ** *.* . :*. : ...... . :: **..*.: . .:* :..:**: *: ::*.:**:*: . :..:*. ::* ..*.. * . * *.. .***: :: . *. ...*. ::: .:* : :.** :* . . *: .**. :::: .*: :: : . .: *:* . .:: ....:* * *: ***::*.::: .: . .:.*: *:: :*: . *. : :. ***. *:*. .*:*. ::.. . :* . :* .: ....*..:. ::: .*...* : .. :* .. :.* *:: *:*.**::*. *:*.. : . :* * * : ***:::.:::. : :.:. :: : :*: . * .* : :* :: *. *:*. *:*: ::. . *. :*.. :*. : ... *..* ::: **. * .:.* :* .. :.* *: ::* :: :*. :..* ...*:.. : . *.. *.. * .. .*** *: * *.: . *. : :..*: *..:.* :* . ... :....*:. :**..*: . .*: : *:. *:. . *: ..* :* ..*.* :*:: :.:::. .: :.:.*: :: :*: . ***. :: *: *.*** *:* .* : : .. . *: *:* . :*. .* : ..*.:.. ::: **. *.::.. :* *.*:.** *: :..: **. .:: ....:. ..: **.** .*: .:* *. .: *: .:***: .*. .* . . : . ::* ..*.. *..: :.*.. .**.:**: . :*: . *. ::: .:: .:::: :. . ....::. .*:. : .. :* .* ...: .. : *: : ::: ***: *.:: . . .**: :*: .. . . : : .: * : ::**. . * *..::: * *: : *: *::: *** . : . : * ** .:** .:: . . :**.*.*:. ***::: :: .:* * ** : . . * : : .:. .* . :**..:.:. :: . .: *. .** * ** ::**:: :* : .. . ::: : ::. *.. * ::. .: .*. : . .** ::**.: :*. . . .*. :: *.. *.:** :* : .*.* ::** .**. :* :* * ::.:*. *:***:* **. *:*.. .:* :..:*:. :**...:** :.**.* .*::. . .* . :.: **: . **:*.. :::. . *. .** **.::: : .: :* ** * .. :::. .*:::..*...*..** . *.*.. **. **.*:. .. ..: *. * . .. .*:************..*:** ***:*.*::* * *::*.:*::***** :::*:*:::.*:**.:*::***:** ::*:***** ** *.:* **:**::**:*::**** ::..**...: :: **.:.* *: : ** ::***:*.*:*** :... :*** *:* * :::..:..: :.:* :**:**..*:*.****. ****:. *******: *:*******.*: * ******** ****.::*:*** **:: :* :::.:**: *:*::*** **:. .:****:*:*** :: :: : *:*:*..*****.**:** **:******: **:", "identical_positions": 939, "similar_positions": 1961, "identity": "20.76%" }, { "cls_id": "homologset.agr.HGNC:16803", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80U95-1", "uniprot_id": "UBE3C_MOUSE", "id": "Q80U95-1", "name": "Ubiquitin-protein ligase E3C", "aln": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAVIIQSFIRGYRDRKQQYFIQRSAFDQCTDSAQPGGTFCLADGPNLTLLVRQLLFFY--KQSEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCSDDSLNVALPMRMLEVFTSENTYLPVLQDSSYVVSVIEQILHYMVHSGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYSSCP----EASRHQVFSAFTEEFLGAPFTDQIFHFVIPAFADAQTVFPYEPFLNALLLLESQS-----SKRCSGVPWLFYFVLT---------------------VGENYLGALSED-GLLVYLRVLQTFLS---QLPAS------PTGTGCPDSTSDSEDDNEETDQ-PNSPE-----------DGRVSAP--YITEECLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQS---SMMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLES-LPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQG-DGPFLDG------------INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFN-PNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTS--ADVDIHHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZHB7-1", "uniprot_id": "D3ZHB7_RAT", "id": "D3ZHB7-1", "name": "Ubiquitin-protein ligase E3C", "aln": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAVIIQSFIRGYRDRKQQYFTQRSAFDQCADSAQPGGTFRIADGPALTLLVRQLLFFY--KQSEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQLKRLMSLCCRLLQNCSDDSLNVALPMRMLEVFSSENTYLPVLQDSSYVVSVIEQILHYMVHSGYYRSLYLLINSKLPSSIEYSDLSRVPMAKTLLENVLKPLHFTYSSCP----EGARHQVFSAFTEEFLGAPFTDQIYHFIIPALADTQTVFPYEPFLNALLLLESRS-----SKRSSGVPWLFYFVLT---------------------IGENYLGALSED-GLLVYLRVLQTFLS---QLPAS------PTGVGRPDPTSDSEDDNEETDQ-PTSPE-----------DGRVSAP--YITEECLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMTTQMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQL---SMMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVSAFQSIGVTTNSEMQHCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLES-PPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQG-DGPFLDG------------INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFN-PNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTS--ADVDIHHLASLDPEVYKNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15386-1", "uniprot_id": "UBE3C_HUMAN", "id": "Q15386-1", "name": "Ubiquitin-protein ligase E3C", "aln": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFY--KQNEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENTYLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCP----EGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNALLLIESRC-----SRKSGGAPWLFYFVLT---------------------VGENYLGALSEE-GLLVYLRVLQTFLS---QLPVS------PASASCHDSASDSEEESEEADK-PSSPE-----------DGRLSVS--YITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQS---SMMPFTLEELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLES-PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQG-DGPFLDG------------INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFN-PNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTS--ADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LY19-1", "uniprot_id": "Q1LY19_DANRE", "id": "Q1LY19-1", "name": "Ubiquitin-protein ligase E3C", "aln": "MFSFEGDFRRTPKVSLGGASRKEEKASLLHRTQEERRKREDERKRLKNAIIIQSYIRGYQDRKQQYAIQRGSFDHCVCQCQSGSGPQLTDSAILSQLVRQLLFFY--RLSEDRPRMIWMCQCLVKHHAQFVKLLTGPERQICLFQIKRLLGHCCRLLQSCEDDSLNVAVPMRMLEVFSSERTYLPFLQDENCVTSLIEQILHYMVQKGFYRSLYVLVNHKLPSSLEYSDTPSIPLAQTLLEHTLKPLHFTYSSCP----PDTRQFVFSAFTEEFISAPFTEQIYHFFVPALSDPKLAFPFQNFLWSLQATIASS-----VQARTQAPWLFYFVLS---------------------VGESGLSSLSEE-GLLLYLNALQTLLP---LLPVT------ECNS-RADINSDSEDEEEMTVQHPAAPD-----------GSWISVH--YITEECVQKLDTKQQTNALLTLVWRDSASEDVFTMMASICHTLMVQHRMMVPRVRLLYSLAFNARFLRHLWYLITSMKTKMITGSMVPLLQVMSRGSPMTLEDSNRIIPLFYLFSSLFSHSLISVHDSEFFGSSAD--GQSQS---SMMPFSLGELVTLSRCLRDACLGIIKLAYPETKTEHKEEYVAAFRSVGVKTNSQVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPSGHWLSDEVNIRADKVTQLYVPSARHMWRTRRMGRIGPLQSTLDVGLEP-PPLSVSEERHLAILTELPFVVPFEERVKIFQKLIYADKREVQG-EGPFLDG------------VNVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFN-PNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELPFASFFLSKLLGTS--ADVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELKPGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAHVPICLEDLKRFTNYSGGYSATHPVIKIFWDVVESFSDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGTDLERLPTASTCMNLLKLPEFCDPQLMRNKLLYAIESSAGFELS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W196-1", "uniprot_id": "Q9W196_DROME", "id": "Q9W196-1", "name": "Ubiquitin-protein ligase E3C", "aln": "MFGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDG----IVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHS--SPDSLWLLRLCKLLDTCLLQLSLSHT---AQAIPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALN-VDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLG---FSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETR-----SNLANYRKVLGHTEADDKK-LRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHS---SRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPS----------VLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFD-PNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKY--SDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTG-DMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53119-1", "uniprot_id": "HUL5_YEAST", "id": "P53119-1", "name": "E3 ubiquitin-protein ligase HUL5", "aln": "MLNFTGQTRRR-NVNLGNRTRNSKKD-LLEKAKRERERRAQDKLKEDASKTIQKSIRRHFSNVRLFKNTFTSSQLVHMIPAYGG---------------KLIYYIS----------QYDLQQLLKLSHNFLSSYPNSLGNRQLLSLLKLYQDDALVAETLSDLNMDCPTVDEFLDSLSVYLCRASFLSYS---------------------------------------------SASKLADVIEAWEVMHSSAS--------ISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSHCSK----------------------------------------GGQKNIAKLLIP------------------------------------NFNNHIAPS-------VLRSD-----------------------NDYVLKFYEKAFIDEVIATTANYVSDEDHVKNLMCYIASSPNQSCKNSVLITLLSNKDFVRRLSWEFFHTKFNAS-------------------------KTEAHPLFSVLAQLIDMHLLISTDRELLD--------------YNSVIPIEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEYEDLYR---EHLEEESDEDMEKEIDLDKERP-------------PLKSLLLNKMKK-RLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISRDNVLEDAFNAFNSIGER-FKASLDVTFINEFG-EEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPS----VVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGG-YKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDLS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:.* *: : .**. ::. .: ::.:: **.:* : : : . : :*. * . . : : * :* :: * ::: ::. . *: : :* . . .:*: :: :. : * :.. .. :.. : . *.: : :. . : : . .. :. * : .. . : : : . : :: . . . : . ** . * :: .:. . . **: :. *:. * * *:. :.: *: :: *:* : . : . :. .: . . : * : : . : . :: . : . . : :: :* . *::. :: * . * : :* *:**.:**::**.:: :: .* .:. * . : *. : ***:: : . .* :: : : ::. * :********: :***. : . .*. *:: :* .. ***. : :: :*:*:::**.:**::*:::.:* ***.** . .: .*.* *. :*.**: * . * . .. ..:::*:* *.. ** * : *: ::**:** : **: **: :: .*: **.. *:*:*:** . : *:*** :*.* :. . * ** *:: * :: ::****** .:.** *** * * * *:* * : ******** ****** : :*.******:..* *:**", "identical_positions": 166, "similar_positions": 274, "identity": "14.32%" }, { "cls_id": "homologset.agr.HGNC:16804", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DBH0-1", "uniprot_id": "WWP2_MOUSE", "id": "Q9DBH0-1", "name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "aln": "MASASSSRAGVALP-FEKSQLTLKVVSAKP-----------------------------KVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIVLN-VTAQSHLDLKVWSCHTLRN---ELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKGS--VVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSGTAIAPETRHQPPSTNCFGGRSR--THRHSGGSARTATAASEQSPGARNR------------HRQPVKNSSSSGLANGTVNEEPTPASEPEESSVVGVTSLP------------------AAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWER--PLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQG-------AMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPR------TQG----MIQEP------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQG--SPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B4F767-1", "uniprot_id": "B4F767_RAT", "id": "B4F767-1", "name": "E3 ubiquitin-protein ligase", "aln": "MASASSSRAGVALP-FEKSQLTLRVVSAKP-----------------------------KVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEVIVLN-VTAQSHLDLKVWSCHTLRN---ELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKGS--VVSGGELTIFLDGPTVDLGSVPNGSAVTDGSQPPSRESSGTALAPETRHQPPSTNCFGGRSR--THRHSGGSARTATATGEQSPGARNR------------HRQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSPP------------------AAASSVSPNPNTTSLPAPSTPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWER--PLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQG-------AMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPR------TQG----MIQEP------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQG--SPGAYERSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLRDLESIDPEFYNSIIWIKENNLDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O00308-1", "uniprot_id": "WWP2_HUMAN", "id": "O00308-1", "name": "NEDD4-like E3 ubiquitin-protein ligase WWP2", "aln": "MASASSSRAGVALP-FEKSQLTLKVVSAKP-----------------------------KVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILN-VTAQSHLDLKVWSCHTLRN---ELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGS--VVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSR--THRHSGASARTTPATGEQSPGARSR------------HRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP------------------AAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWER--PLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQG-------AMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPR------TQG----MIQEP------ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQG--SPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F6P346-1", "uniprot_id": "F6P346_DANRE", "id": "F6P346-1", "name": "E3 ubiquitin-protein ligase", "aln": "MAAASVSQSASIQA-IEKSQLTLKVLSAKPQSP--------------------------KLPNRHSRLSSFVEVTADGLSSETKKTGKRSGHLELQWNEDLTLN-VTPQSRLDLKVWSCHTLRK---ELLGSATIDLLDTLRTHDGKMENVQLSLVLQTENKGS--VVAGGELNVCLDGLVVDLGSLPNGSAASDKIH-----SSRSSLHRAHSEETPSTSSPRGRSLGQSSRGSCGDSPAEIQGAALTNGDVNG------------ALAETTSRHNSKTTVNNLSSAGKGETAANGLESAHLTCPA------------------PSSPSLSSNPPDGTVPPPAA----EPPASTEQSDTTSDTQNTDALPAGWEQRILPHGRVYYVDHNTKTTTWER--PLPPGWEKRVDQRGRFYYVDHNTRTTTWQRPTAESVRNYEQWQSQRSQLQG-------AMQQFNQRYLYQPSGAVVENDPLGALPPGWEKR-QDNGRVYYVNHNTRTTQWEDPR------TQG----MIQEP------PLPPGWEMKYTAEGVRYFVDHNSRTTTFKDPRPGFESGSRQGG-SPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKKPTLKDLESIDPEFYNSIMWVKENDLEECGVELYFAQDMEILGKVTTHQLKDDGENELVTQDNKEEYIGLLTDWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRHYTKNSKQIHWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREKLLFAIEETEGFGQE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9Y0H4-1", "uniprot_id": "SUDX_DROME", "id": "Q9Y0H4-1", "name": "E3 ubiquitin-protein ligase Su(dx)", "aln": "MADGNGLPAGAASGGMEAGQTVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLID--SKSKRKTDLVKNSYLPKWNEEFTVL-ITPNSTLHFKVLDHSSFRKD--AMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPR------TQGQEVSLINEG------PLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39940-1", "uniprot_id": "RSP5_YEAST", "id": "P39940-1", "name": "E3 ubiquitin-protein ligase RSP5", "aln": "MPSSISVKLVAAESLYKRDVFRSP--------------------------------------------DPFAVLTIDG--YQTKSTSAAKKTLNPYWNETFKFDDINENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLD---EDTATSSGRPREETITRDLKKSNDGMAVSGRLIVVLSKLPS--------------SSPHSQAPSGHTASSSTN---------------------TSSTTRTNGHSTS---------------STRNHSTSHPSRGTAQAVESTLQS---------------------------------GTTAATNTATTSHRSTNS-------TSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKR-----PTLDQTEAERG--NQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGGGS-----NIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPR--LPSSLDQN---VPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV-LDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. . : . ..:. : * ..:.*. *** : . :. :* * ::* . .::: :** : : . * . * : .. ..: . : :..: : : .. . * . .. : .. : . : : : : **.*** * ** *******::* *:: * : ** :: **. *: .. .. :: . . : . ** ** ***:: :.*.*:*:*:.*** * *** * * *:: .**.***:: * . :*****:: **:.*** .. *.*.** * ** . **.: :*.* *:.:***::::**. . :*::** * : *********::**:*******::**:******: :** :**** * :**:** **:****.:.:.::* :*: : *. .:** **.*: .::*:* :*.*.***: *: :*.:: ::* * * * :*:: :** .*.. **: **:**: * *:**:. :::* *:*::****: * : : ***:****:: *: ::*:.**:: : ** * ...: : ***: * * ***:* *****.***.*:**.** :* **:**::* *::.*: **:*******:*** * . :.: :** *:*** ** **", "identical_positions": 248, "similar_positions": 225, "identity": "25.67%" }, { "cls_id": "homologset.agr.HGNC:16805", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M759-1", "uniprot_id": "F1M759_RAT", "id": "F1M759-1", "name": "", "aln": "MSVQNSDWSLQQDNPIFREPDPPVNTDSDSGHRPVQGYGDISVQAPTSSSLGPPCPDISQASNWPGFRTLLQQLPPQDSDERYCLALGEEELAQLRLFCAQRKQKSLGQGVARLLPPKLEGHTCEKCKKLLNPGEYGVFAARAGERCCWHRPCFACQACGQALTNLIYFYHDGHLYCGRHHAELLRPRCPACDQLIFSQRCTEAEGRHWHENHFCCQDCAEPLDGGRYALPGGSPCCPSCFARRYRSGGSSSIGAAEGQASLE--GPDPSVGWNRASSDDKITSRAALPSA--VAIP-----SEASKQRDR---NSPQTPK-------------EGSPCPTCSSSSESEPEGYFFGQRLPDLWKTPENLQADDRGISRKHCAIC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3Z6Q6-1", "uniprot_id": "D3Z6Q6_MOUSE", "id": "D3Z6Q6-1", "name": "", "aln": "MSVQNSDWSLQQDNPIFREPDPPVYTDSDSGRRPVEDYEDTSAQAATCSSLGPPCLDINQVSNWPGFRTLLQQLPPQDSDERYCLALGEEELAQLRLFCAQRKQKSLGQGVARLLPPKLEGYTCKKCKKLLDPGEYGVFAARAGEQSCWHRPCFACQACGQGLINLIYFYHEGHLYCGRHHAELLRPRCPACDQLIFSQRCTEAEGQRWHENHFCCQDCAGPLDGGRYALPGGSPCCPSCFSKRYRSAGSSSVGVAEGQASFEEEGPDPSVGWNRASSDDKITSRAALLSA--VPTLTLETLNGASKRQDR---DGPQTPGSPI----------EDSPCPTCSSSSESEPEGFFFGQRLPEPWKTPENLQADDRDISRKHCTIC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q2TBC4-1", "uniprot_id": "PRIC4_HUMAN", "id": "Q2TBC4-1", "name": "Prickle-like protein 4", "aln": "----------------------------------------MSPQGPAVLSLGSLCLDTNQAPNWTGLQTLLQQLPPQDIDERYCLALGEEERAELQLFCARRKQEALGQGVARLVLPKLEGHTCEKCRELLKPGEYGVFAARAGEQRCWHQPCFACQACGQALINLIYFYHDGQLYCGRHHAELLRPRCPACDQLIFSWRCTEAEGQRWHENHFCCQDCAGPLGGGRYALPGGSPCCPSCFENRYSDAGSSWAGALEGQAFLGETGLDRTEGRDQTSVNSATLSRTLLAAAGGSSLQTQRGLPGSSPQQENRPGDKAEAPKGQEQCRLETIRDPKDTPFSTCSSSSDSEPEGFFLGERLPQSWKTPGSLQAEDSNASKTHCTMC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *..: ***. * * .*..**.*::********** ************ *:*:****:***::********: *****:**:**::**.*************: ***:**********.* *******:*:************************ *******::************ **.***************** .** ..*** *. **** : * * : * :::* :. **: * :* . :* :::. : .::* :.:* .******:*****:*:*:***: **** .***:* . *:.**::*", "identical_positions": 207, "similar_positions": 68, "identity": "53.91%" }, { "cls_id": "homologset.agr.HGNC:16806", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62671-1", "uniprot_id": "UBR5_RAT", "id": "Q62671-1", "name": "E3 ubiquitin-protein ligase UBR5", "aln": "----------MNKQAVKRLHMLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRICRIGFSVQPDRLELGKPDNNDGSKLNSSSGTGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSE------------------------LLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNPDKKNTPVQSPVSLGEDLQWWPDKD-GTKFTCIGALYSELVAVSSKGELYQWKWTESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGVQSLN-VRGGRQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMEK-----------------------------ASKTIETKPESKQEPVKTEMGPPPSPAS-TCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGT-----------SSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIP---EKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSVAFLGQNERSVAIFT----AGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFA-----------ERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS----LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPSMDPDGDIDFILAPAVGSLTTAATGGGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEVSGSEKEE--DVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRP-PRIRED--------------RNRKTASPD-DSDMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQENKDPLSASSRIGHLLPEEQ-VYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASS---KKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGREEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGHHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSS-SSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCLVEVTMDRNCLEVLPTKMSYAANLK-------------------NVMNMQN----------RQKKAGEDQSMLAEEADSSK------------------------------------------PGPSAHDVAAQLKSSLLAEIG----------------------LTESEGPPLTSFRPQCS-----FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFG--RRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNAN--KGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELIVAHGRENGADSILDLGLLDSSEKVQ-ENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80TP3-1", "uniprot_id": "UBR5_MOUSE", "id": "Q80TP3-1", "name": "E3 ubiquitin-protein ligase UBR5", "aln": "MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRICRIGFSVQPDRLELGKPDNNDGSKLNSSSGTGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSR------ERDSE------------------------LLRERESVLRLRERRWLDGASFDNERGSTSKEGESNPDKKNTPVQSPVSLGEDLQWWPDKD-GTKFTCIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-NLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMEK-----------------------------ASKTLETKPESKQEPVKTEMGPPPSPAS-TCSDASSIASSASMPYKRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGT-----------STNTTCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIP---EKTEILAVNVDSKGVHAVLKTGSWVRYCVFDLATGKAEQENNFPTSSVAFLGQDERSVAIFT----AGQESPIVLRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNRQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFA-----------ERLSAVEAIANAISVVSSNG-------PGNRAGSSNSRS----LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPSMDPDGDIDFILAPAVGSLTTAATGSGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRAYSAAITILETAQKIAKAEVSASEKEE--DVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRP-PRIRED--------------RNRKTASPE-DSDMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGSQENKDPLSASSRIGHLLPEEQ-VYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASS---KKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQASSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGHHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSS-SSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNPQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSVMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRR-ATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCIVEVTMDRNCLEVLPTKMSYAANLK-------------------NVMNMQN----------RQKKEGEEQSLLAEEADSSK------------------------------------------PGPSAPDVAAQLKSSLLAEIG----------------------LTESEGPPLTSFRPQCS-----FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFG--RRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNAN--KGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGN---PSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQ-ENRKRHGSSRSVVDMDLEDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95071-1", "uniprot_id": "UBR5_HUMAN", "id": "O95071-1", "name": "E3 ubiquitin-protein ligase UBR5", "aln": "MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSE------------------------LLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKD-GTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEK-----------------------------ASKTTEAKPESKQEPVKTEMGPPPSPAS-TCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGT-----------SSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIP---EKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFT----AGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFA-----------ERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS----LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEE--DVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRP-PRIRED--------------RNRKTASPE-DSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQ-VYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASS---KKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSS-SSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRR-ATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLK-------------------NVMNMQN----------RQKKEGEEQPVLPEETESSK------------------------------------------PGPSAHDLAAQLKSSLLAEIG----------------------LTESEGPPLTSFRPQCS-----FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRDRDLLIQQTMRQLNNHFG--RRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNAN--KGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGN---PSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NV16-1", "uniprot_id": "A0A8M1NV16_DANRE", "id": "A0A8M1NV16-1", "name": "E3 ubiquitin-protein ligase UBR5", "aln": "MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNCNSHPHLIPLEQAKLKQCVVGPNHAGFLLEDGRICRISFAVQPDRLELGKPDGNDGSKLSSVSGAGRSSRPGRTSDPPWFLSGSDTLGRLAGNTLGTRWSSGVNGGGGGSSGRSSTAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSE------------------------LLRERESVLRLRERRWLDGASFDAERGSTSREGEPSLDKKSVPLQSPVTLGEELQWWPDKDYVTKFVSIGALYSELVAVSTKGELYQWKWNEPEPYRNAQNPSIHHPRVPFLGLTNEKITHLSANSIRATVATENNKVATWVDETLSTVAAKLEHGAQTFPELQGERIVSLHCCALYTCAQLEN-SLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSIPNITVGTQVCLRNNPLYHAGAVAFSVNAGIPKVGVLLESVWNMNDSCRFQLRSPESLKNMEK-----------------------------NTKTQETKTESKPELVKTEMGPPPSPAS-TCSDTSSIASSASLPYKRRRSTPAPKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGT-----------SSSVSSQSAAPTDSDPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIP---EKAEILAVNVDSKGVHAVLKTGSWVRYCVFDLATGKAEQENHFPTSNLAFLGQSERNVAIFT----AGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPIASLGMGVHSLANLPSNSTIKKKAAIIIMAVEKQTLMQHVLRCDYEACRQYLISLEQAMLLEQNPHALDTLLGHRCDGNRNVLHACVSVCFPVSNKETKEEEEAERSERNTFA-----------ERLSAVEAIANAISVVSSNS-------SGNRTGSSSSRG----LRLREMMRRSLRAAGLGRHESGPSSSDHQDPVSPPIAPPSWVPDPPPMDPDGDIDFILAPAVGSLTTASTGTSQGPSTSTIPGPSSEPSVVESKDRKANAHLILKLMCDSIVLRPHLRELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQKIAKGEPGLGEKEDTASVFMEMICPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLVTTPNSRGEHILLFLVQTVARQSVEHCQYRP-PRIRED--------------RNRKAASAE-DSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIAHLLPEEQ-MYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYTPGRREEAINVTRRFLRSVARVFVILSVEMASS---KKKNNFIPQPIGKCRRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAVQGSEELFSVEPLPPRPSPDQSSSSSQSASSYIIRNPQPRRSSQSQTARGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDDQEEQGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSS-SSQSDDVDQETFLLDEPLERTTGSAHANSAAQAPRSMQWAVRTTPSQRSGGGAPSSSSAPAASSTGLIYIDPSNLRRSSAISTSAAAAAAALEASNSSSYLTSASSLARAYSIVIRQISDLMSLIPKYNHLVYSQYPAAVKLTYQDAVNLQNFVEDKLIPTWNWMVSIMDSTEAQLRYGSALSSAGDPGHPSHPLHASQHAGRRERMTAREEASLRTLEGRRRAATLLTARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNLQTTLDTTQIDRKRNRELLELGLDNEDSEHENDEDTNQSSTLQDKDEEPVPAETGQHHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSYMASKGLTDLTVDMNCLQILPTKMSYSANMK-------------------NVMSMES----------RQR-GGEEQPVAEQEMDVSK------------------------------------------PGPSPHDLAAQLKSSLLAEIG----------------------LTESDGPPLPTFIPHCS-----FMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDLAL-EVDRDREQLIQQTMRQLNAHFG--RRCTTTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNDKLPNLDCVQSVS--KGMQANLMQRLRNR---DRERER-----RSGGLRAASRRDRDRDSRRQLSIDTRPFRPASEGN---PSDEPEPLPAHRQALGERLYPRVHAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVEEAMELLITHGRENGADSILDLGLLDTPEKAQQENRKRHGSTRSVVDMELDDPDDGDDNAPLFYQPGKRGFYSPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTEEAEAVFAAMDLAFAIDLCKEEGAGQVELLSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P51592-1", "uniprot_id": "HYD_DROME", "id": "P51592-1", "name": "E3 ubiquitin-protein ligase hyd", "aln": "MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSHRIFEQLKIP-VKEVVIGPAHIGVLLEDGKAFRVSFSINSEKLDLTKSD----AKCSTSGGSGTASASKAPSS-------SRPMARSRARLLRATGRSNSTGQGSGS------------RSTGVIIGGSTS------SRPLVTVPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGADN-YVP-EDLISLLDNGFSGDNNSVIIDPSDGLFSEEIFSN-YSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSGTALTGNSGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEPSPMLSPIWISEELQPWPEKS-SVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYK-SETENVYHPKTVSLNIV-ERVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVAT----DINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTSHKRTKRATTKEDSNAPQEGRKDEELWEVKDVVFVEDKVG-PVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKEDDWQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIHVIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPAMLSGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGRLER-----EDQADTALVVEERCDGARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWPAETPAASNLSASSSQNVSDSIEDDISKIIPSSS---QSSMLSNIKLGSP-TYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQDP---------QLKEAMIFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSDH--LDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD---NSDDLFSVDPLAP---SNVESPSEQ----ILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVIN---REANSHNQDDELIENQRNEDGMQDDESDND-----FTFNDAETESDSDDNQSNQE---VQRSVQAGATVGSEN---DIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNAR-SDLAPQTMQWAIRSRDTARSSVRVPTG--------SNMVFIDPMALRRS-TVPASTTVTTPSIEP---HTMATTASNLARAFGITIRQISELISILS-YN--VLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVN-------IMGS-----NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNLSPMTESYDTDD-ELANLEEFNADVQMSASSMPSGSQGT-RRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLP--LLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARER---KALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQK--------------SETSAQSSQPK---KSPSVVVVDPVD----DDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . :****:*:*::. .** : *: . :*: *:** * ..*****: *:.*:::.::*:* *.* :* .: .*:* :* . .*. * .:.* .. * : *. * *.** *.* ** * *:* .:**: :********:********.:*************************:.:* :: *.: *:* ***:**** .: . : ***** :*.:***:* *.*:*. :.*: *.* **: : :**:. * *:*:: . : : . * .:. . .*: *: **: :.*:** **:*. .:* *******::*:* .*:****:*.:.***: ::. .::**:. *.:. *:: :*** **.:*.**.*:****:** *. :.:**** . :: *: .: *..:: *:*** .: *. .:*****:**.**: : :* *:*.*** . .. : * ** ::: *:*::*::.*: . *:**** *::***.:.* **::: . :: ..::* :*. :: .:** . : :* ******* ****:.*::* :. . . :* : :** * :::****** . ********** :***:**. ::... :: : . .. *:***** :::*:.:*. :.: ** :*: ***: : ::**:: ***:*:*.: *. . ::*.:::* . * **: ***. :*:*. .: : :*:.*.*:******::**:****:*.*:**:*:****: *: *.. ** : :. .:*.*..: : .:.*.** *:**** : . * **: :: .: .**** **::**** :* * ***:: :. : *::::. . : *.:** . *. *** ... :**:.* . .**:**.* :.: : : . :::::* . * .. : ... . ... ::. : :..: .::: *.. *.* *. . ..: :*: :* **: :* * .*:*:* .:**:***:* **** :** *** *.* :*:: ::: : .: *: *.*: .*:***:*:* ***********:****:****:**** ***********************:**************:****: : *: ** :*:: *:*** **:** :****:***.** **: *** *:*: ***:::.: *.**********:**: ****:* ****::**** *::... * .*.* : .* :::: * *: ** ***.*****:.* :**** ***:**** ...* :** *. **:*********:.:* .. :*.:. : : .* :***:* ::****:*:*:**.***:*:.*******::*:.:* .*::****:**.* .: *.*.* ::::. : :: : :. : : : *. **:: * : *::::* *:: : :* :*:..::. : *******:.*:***: :*** :.**.*** .: .:* **:* ...:.:.*.* ..:*** .:* : :: *** : .::*. : **::****:*. *:. .*:. :.:::*** **** ::.:*::.::.::*. : *:**.****:.*.*****:*:.::. ** * .: :::*: ::*: :* :**.:* .**:**.::**.*****::*: *:. **.** ***: * ::. : :. .:*:. :: :: : .:* **:.*.*******..** *.*****: :*:*:***::*::*::: . : . * .. . : . *.:* * * :: . . :. .. . . * :.*.** **:* *** .*: **:** *:****:*******:::::**.. . * :: .. : . . :: **::.:: .:* ** . . :: *.:: :* : .: *..:. .: . .* * *. :* . * * .: * :. : * ::**.**:*:*:*******:*** * **:*.** ** *** :***.****** *.*** * :::*:*: ** **:::** :** * .*::.:**********************:**:*:*:. *:***:.:* . . . : . **.* . .*:: *... : * *:* : *.:*:**: *....: *.. : *..* * :******:::::: :.*.********:...*** :::*:::** :*:**:*:: : : : ..* .: * .: *** :: * *** ****.*******:** * : *:*.******::********* *: *:***:* :****:::**:*****.:***:**:* :*:.:.: .: *:*.*.:** **** *: **:..* ::.**. *::****:*:*:*:: *:.*.*::.*::****.*:: :*****:***:** *::**. ***:*:*****.*..:***:**:*******:*.: **********.**:**********:**:****.**.*************:******.**:.*:*:***:******", "identical_positions": 1112, "similar_positions": 941, "identity": "36.75%" }, { "cls_id": "homologset.agr.HGNC:16807", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K612-1", "uniprot_id": "A0A0G2K612_RAT", "id": "A0A0G2K612-1", "name": "E3 ubiquitin-protein ligase", "aln": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGG------GSVVDCRGLLE------------------------------------------------------------NEGTVYEDSGPGRPLSCL-------------------------------MEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVR----------------GSLQTPQNRPHGHQSPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLH---------------HIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQ---------------------------------RYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL-IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9HCE7-1", "uniprot_id": "SMUF1_HUMAN", "id": "Q9HCE7-1", "name": "E3 ubiquitin-protein ligase SMURF1", "aln": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTG------GSVVDCRGLLE------------------------------------------------------------NEGTVYEDSGPGRPLSCF-------------------------------MEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVR----------------GSLQTPQNRPHGHQSPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLH---------------HIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQ---------------------------------RYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL-IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9CUN6-1", "uniprot_id": "SMUF1_MOUSE", "id": "Q9CUN6-1", "name": "E3 ubiquitin-protein ligase SMURF1", "aln": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGG------GSVVDCRGLLE------------------------------------------------------------NEGTVYEDSGPGRPLSCL-------------------------------MEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVR----------------GPLQTPQNRPHGHQSPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLH---------------HIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQ---------------------------------RYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL-IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9V853-1", "uniprot_id": "SMUF1_DROME", "id": "Q9V853-1", "name": "E3 ubiquitin-protein ligase Smurf1", "aln": "MNKLDYPRRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPR------------------------DFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.: . *...: *:*:*:***:***:**:*********: ***:** :**: *.:****** ****::* *:***:***::**** *:*******: : *. **.:*:***** **.*.* : *****::** ::* . * *. * ** * *.* :** *. :* *:.:* * :.::: * : :*.* . * ** * . . ::**:::.:** .** ** *** *** ****** * ************ * : :. * :****.*** *.*.***:***************** * .: * .: .:: : **. :*.**** **:.** **. ***:****:****:******** *****.**::*******:***************:**.:***** ******* *: * *******.:************* :*:****** ::****.*******.*** *.*:*.***:**:**.*:**.:*: ::: **.**:*:** :: *****.* .:*******:***:****:******* ********* ****.***:***::****:***:..**:***:.*******. ::. * ****.**::..* ***********:*******:********.********* *. *:*************:****:*: * :** ***********", "identical_positions": 450, "similar_positions": 161, "identity": "41.4%" }, { "cls_id": "homologset.agr.HGNC:16808", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8IWV7-1", "uniprot_id": "UBR1_HUMAN", "id": "Q8IWV7-1", "name": "E3 ubiquitin-protein ligase UBR1", "aln": "-MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQ----------------EESVQMSIFTPLEWYLFGEDPDICLEKLK-------HSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHR--YKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRCPLNEE-------VIVQARKIFPSVIKYVVEMTIWEEE------KELPPELQIRE----------------------------------------------KNERYYCVLFNDE--HHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAG--------------------AYAACQEAKEDIK--------SHSENVSQHPLHVEVLHSE----------IMAHQKFALRLGSWMNKIMSYSSDFR-----------------------------------------QIFCQACLREEPDSENPCLISRLMLWD------------AKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSIS-ITALSVQMFTVPTLARHLIEEQNVIS---VITETLLEVLPEYLDRNNKFNFQG--YSQDKLGRVYAVICDLKYILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSK------------------------TVV-QSCGHSLETKSYRVSEDLVSIHLPLSRTLAGLHVRLSR-----LGAVSR---LHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQD-VKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTIS-----TKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKE---EVTMREIIHLLCIEPMPHSAIAKNLPENE--NNETGLENVINKVATFKKPG-VSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSK--VINLLNCDIMMYILRTVFERAIDTDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMN---IQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSE--SIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKE----------DSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDLAYGT-YTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVD---LFDLESGEYLCPLCKS-LCNTVIPIIPLQPQKIN------SEN-ADALAQLLTLARWIQTVLARISGYNIRHAKGENP-IPIFFNQGMGDSTLEFHSILSFGVESSIKYSNSIK-----EMVILFATTIYRIGLKVPPDERDPR-----------------VPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQ-----RITCPQVLIQKHLVRLLSV---------------VLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDT----GLPLAQVQEDSEEAHSASSFFAEISQYTSG----------------------------------------SIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNS-------AEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQ--------KNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHAL-HCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "O70481-1", "uniprot_id": "UBR1_MOUSE", "id": "O70481-1", "name": "E3 ubiquitin-protein ligase UBR1", "aln": "-MADEEMDGAERMDVSPEPPLAPQRPASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQ----------------EESVQMSILTPLEWYLFGEDPDICLEKLK-------HSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHR--YKMHTSTGGGFCDCGDTEAWKTGPFCVDHEPGRAGTTKESLHCPLNEE-------VIAQARRIFPSVIKYIVEMTIWEEE------KELPPELQIRE----------------------------------------------KNERYYCVLFNDE--HHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAG--------------------VYATCQEAKEDIK--------SHSENVSQHPLHVEVLHSV----------VMAHQKFALRLGSWMNKIMSYSSDFR-----------------------------------------QIFCQACLVEEPGSENPCLISRLMLWD------------AKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSIS-ITALSVQMLTVPTLARHLIEEQNVIS---VITETLLEVLPEYLDRNNKFNFQG--YSQDKLGRVYAVICDLKYILISKPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTK------------------------TVV-QLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSR-----LGAISR---LHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQD-VKCREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELTDAFNKTIS-----TKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTRE---EVIMREITHLLCIEPMPHSAIARNLPENE--NNETGLENVINKVATFKKPG-VSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSK--VVNLLSCDVMMYILRTIFERAVDMESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLESQKDMITWILQMFDTVKRLREKSCLVVATTSGLE--CVKSEEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKE----------DSIMEEESTSAVSEASRIALGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPVDHLGETLDPLFMDPDLAHGT-YTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVD---LFDLESGEYLCPLCKS-LCNTVIPIIPLQPQKIN------SEN-AEALAQLLTLARWIQTVLARISGYNIKHAKGEAPAVPVLFNQGMGDSTFEFHSILSFGVQSSVKYSNSIK-----EMVILFATTIYRIGLKVPPDELDPR-----------------VPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQ-----RTTCPQVLIHKHLARLLSV---------------ILPNLQSENTPGLLSVDLFHVLVGAVLAFPSLYWDDTVDLQPSPLSSSYNHLYLFHLITMAHMLQILLTTDTDLSSGPPLAEGEEDSEEARCASAFFVEVSQHTDG----------------------------------------LAGCGAPGWYLWLSLRNGITPYLRCAALLFHYLLGVAPPEELFANS-------AEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDPALLKSLKQ--------KSAVVRYPRKRNSLIELPEDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACVFHAL-HCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M9P0T8-1", "uniprot_id": "A0A8M9P0T8_DANRE", "id": "A0A8M9P0T8-1", "name": "E3 ubiquitin-protein ligase", "aln": "------------MAES----LSAAQLSTKWQEASNRGSAILRYLGEQVPLIYCLEVELQHAEE----------------ELKVEQRLLYPLEYFLFGEEPCVGLEKLQRY----NSSSSAQQCGRVFKEGETVYSCRDCAIDPTCVLCIECFQKSVHKSHR--YKMHASSGGGFCDCGDVEAWKTGPCCSQHDPG-TEATMETDECVMDPG-------LQERAQMLFHLLLQYTTDMLIWEEN------NDLSEELKPKV----------------------------------------------KEDSYFCILYNDE--HHSYDHVIYTLQRAIACDQNQAQVYTALIDKEGRRAVKRG--------------------TLRTCQQAKDNIR--------RNSEHIIQKPLRVEVLHTA----------VMAHQTFALRLGAWFQKIIGYSVGFR-----------------------------------------DVFCQMALEPASDNDKLSLISRLMLHD------------AKLYKGARKVVHELIFCSLLMDTEYKRQFAMKFTEHYKQLQEDFISDDHQRNIS-ITALSVQIFTVPTLARQLIEEGTVIK---VIIDTVMDMMREHLDNNHRFHFQG--HNPDKFFRVQVIFHDLRYILISKPSIWTEALRVKFLEGFRVFLHFLGCMQGMEEVKRQFGQHVEVEPEWEAGFTLQMQLRHILAMFQDWCSSDERVLLLAFQECHRALMSCTNQPFRSEP------------------------KDS-YMCKQILHARPYKVSQEPVSIHLPISRLLAGLYVLLCQ-----TGAIQY---LPDFVDPAQLNFTELAEQPLRCIVLAAQVCADMWRRNGLSLVSQVYYYQD-VKCRDEMFDKDVIMLQIAASKMDPNHFLMLVLLRFELFDIFNGNCS-----SKDQEVLKQWNRLTEEMLYLLIIIVGERYVPGISNVTKE---DVIMREVIHLLCIEPMAHSTLIKSLPENE--NHETGLETVIAKVANFKKPG-VSGHGLYNVKKECLKEFNPFFYHYSRPQHSKAEEAQKERRSQESSEKALRPPVPPPFRPAFSS--IVNLLCCDIFIHVLRRILQKAVEDRSNQWTEPMIQRALHLVGQALLEETTQLENSSAEEVTFDFSLKAKKTGSEQGKS--LLHFLTKMKSLPSLKVLKDMIAWNLQMFEVVKCLREKSS--PAASFAMD--HSKAEESVQDKE---QKRKAEAAKAHRRKIMAQMSAMQKNFIESNKILYENMPESSSQS----------DTAASLDSFVMDVDKNRVAVGPQQGVWSLDWETLTCILCQEEQEVQAQAPAMVLTACVQRSTVLTQSRGKTLSPK-VDYYPLFMPPDLAVGT-HTGSCGHFMHATCWQKYFEAVQSTTRNRLHAEL--IIDLENGEYMCPLCKS-LCNTVIPLIPVEPSSLN------YES-AQLVGQHLTLMRWIQIMSSRIRGLKAMWTADGSD-AAEKAAAPFDEGQTEFRSILSFGVQEPPKFSRSIT-----EMLVVCATTVHRVGLQTPPNDLCPF-----------------VPAMSWNTCAYTIQAVENMLQDEGKALFGSLKNRQLSGLKALVQFSAAQ-----RMKCNQVVIQKHFADMLAV---------------LVPVPHVENTPSILEVDFFHLLVGLVLSIPSLYQEEAVDLQPSAVSTAYNHLYLLQLITVGHMLQVLLAAHD-----CAVMAVAEEGDEAQAAAEFFSTVSQHTDR----------------------------------------MKSGVLS--FSVEGVKRGVLPFLRCAALFFNCLTGVPPPDELSVSAEL-----PESQLPLLCSYLSLPSNLFQLFQDHRDVMTTLINRWCGNTAISKALKG--------EMHMIRYPRKRNRLIDLPEDYSVLLNQASHFKCPNSSDDERKHPTLCLLCGVMLCAQSSCCHEQLNGEEVGACTGHAA-ICGAGVGLFLRVRECEIVLMASKTRGSPYPAPYLDDYGETDPQLGRGNPLHLCPERYRKLLHLWQQHCVLEEIARSLELLNVMFPFEWQML", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VX91-1", "uniprot_id": "UBR1_DROME", "id": "Q9VX91-1", "name": "E3 ubiquitin-protein ligase UBR1", "aln": "--MDRYDMEDVVVAPPAECSSPLKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVIT------LKCMFKESLAKEEIIDVVVEFMLGDNPSSALEKLR------LEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHK--YKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESK---ILTDA-------VLERVEICFGAILAFCVSYLEIEPN------ASLQCLDGNVEG------------------------------------------GQVDGAQYCTVLYNDE--SHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCD--------------------TFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIG----------AVACQQFALQLLGWFQEFLVRHYLFR-----------------------------------------KTFSELVQR----KQETFCIRHILEYD------------VKLWKTARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFS-IVSLSVQLFTVPSIAHHLIAHEGIFD---KLLHTFYHVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLSLKPDVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMRALVSNSFIVGGEKV------------------------MQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGA-----HDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRN-VRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASIFDEFLELLIVIIGERWMPGVSMVTEE---DRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTP--MANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEELS------EHYPFLSFYERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSRVIFTTPN---------------LRNSQSAL-HISCCGHVMHYSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRT-LSNAIIPVTETLPAFSA------PPSPNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHADYIEGIEFLKKALLNTMKIQQSHLKDHPAIESIE-----------------MVPILWDSCSYTLQALEIYLYAVEKPLKAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSR---------------LLDTIFNQNDTSVLEWDCFRVLVPFQFGVLNLMVPE-KGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVE---KEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQ--------PDRFDLMCQYLGLDP-MLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQVEPCLRPLPRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAH-ACGAEVGIFLRIRDCQVVYLG-RGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGLHGEIARLNDNANVAAAAQWHHM", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P19812-1", "uniprot_id": "UBR1_YEAST", "id": "P19812-1", "name": "E3 ubiquitin-protein ligase UBR1", "aln": "MSVADDDLGSLQGHIRRTLRSIHNLPYFRYTRGPTERADMSRALKEFIYRYLYFVISNSGENLPTLFNAHPKQKLSNPELTVFPDSLEDAVDIDKITSQQTIPFYKIDESRIGDVHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKEEDVWNDSVNIALVELVLAEVFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDE--YHNYSQATTALRQGVPDN-VHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWITHCLNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYID------------LSILADGNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFD------------NRYWKRLRKDIQNVIIPTLASSNLYKPIFCQQVVEIFNHITRSVAYMDREPQLTAIRECVVQLFTCPTNAKNIFENQSFLD---IVWS-IIDIFKEFCKVEGGVLIWQRVQKSNLTKSYSISFKQGLYTVETLLSKVHDPNIPLRPKEIISLLTLCKLFNGAWKIKRKEGEHVLHE---DQNFISYLEYTTSIYSIIQTAEKVSEKSKDSIDSKLFLNAIRIISSFLGNR------------------------SLTYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSL-----KDAYEA--------LEDCSDFLKISDFSLRSVVLCSQIDVGFWVRNGMSVLHQASYYKNNPELGSYSRDIHLNQLAILWERDDIPRIIYNILDRWELLDWFTGEVD-----YQHTVYEDKISFIIQQFIAFIYQILTERQYFKTFSSLKDRRMDQIKNSIIYNLYMKPLSYSKLLRSVPDYLT-EDTTEFDEALEEVSVFVEPKGLADNGVFKLKASLYAKVDPLKLLNLENEFESSATIIKSHLAKDKDEIAKVVLIPQVSIKQLDK--DALNLGAFTRNTVFAKVVYKLLQVCLDMEDSTFLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIANAKS---DVFSESIVRKADYLLEKMIMKKPNELFESLIASFGNQYVNDYKDKKLR--------QGVNLQETEKERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFDEQDNDVDMVG---------EKVYESEDFTCALCQD-----------SSSTDFFVIPAYHDHSPIFRPGNIFNPNEFMPMWDGFYNDDEKQAYIDDDVLEALKENGSCGSRK-VFVSCNHHIHHNCFKRYVQKKRFSSNAFICPLCQTFSNCTLPLCQTSKANTGLSLDMFLESELSLDTLSR---LFKPFTEENYRTINSIFSLMISQCQGFDKAVRKRANFSHKDVSLILSVHWANTISMLEIASRLEKPYSISFFRSREQKYKTLKNILVCIMLFTFVIGKPSMEFEPYPQQPDTVWNQNQLFQYIVRSALFSPVSLRQTVTEALTTFSRQFLRDFLQGLSDAEQVTKLYAKASKIGDVLKVSEQMLFALRTISDVRMEGLDSESIIYDLAYTFLLKSLLPTIRRCLVFIKVLHELVKDSENETLVINGHEVEEELEFEDTAEFVNKALKMITEKESLVDLLTTQESIVSHPYLENIPYEYCGIIKLIDLSKYLNTYVTQS------------------------------------KEIKLREERSQHMKNADNRLDFKICLTCGVKVHLRADRHEMTKHLNKNCFKPFGAFLMPNSSEVCLHLTQPPSNIFISAPYLNSHGEVGRNAMRRGDLTTLNLKR---YEHLNRLWINNEIPGYISRVMGDEFRVTILSNGFLFAFNREPRPRRIPPTDEDDEDMEEGEDGFFTEGNDEMDVDDETGQAANLFGVGAEGIAGGGVRDFFQFFENFRNTLQPQ----GNGDDDAPQNPPPILQFLGPQFDGATIIRNTNPRNLDEDDSDDNDDSDEREIW---", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q07963-1", "uniprot_id": "UBR2_YEAST", "id": "Q07963-1", "name": "E3 ubiquitin-protein ligase UBR2", "aln": "--------------MEDSDLSITNIRDFLTELPKLAKCEYSETTSYLLWKTLNLRLKHSDNDINWRS-----------LVSILNSEAWENEKYRDILNGRKWRTLEFENDHHSVGNMHIGTACTRLCFPSETIYYCFTCSTNPLYEICELCFDKEKHVNHSYVAKVVMRPEGRICHCGDPFAFNDPSDAFKCKNELNNIPISNDNSNVTDDEN-----VISLLNYVLDFLIDVTVSYKEEAEAHSSERKASSLMHPNQNSITDDIMEKHECEPLVNDENFVFFDNNWSN--------------TRKEAHMEWAIQIEEEECNVHYMDLASTITRILNTPVEYAISITKALEDSHDVVTVLQ------------------SENFFEIDQIAKEFQKENIVVHVRKADDIFKRKLTDDLTDWLYSLCFKAATSLQNKYALRISMLDVWYSHFSKMRVSPTNTNPDFSKINLLGGFLISNEDSDESWFKPWSLENIEDERISKILTNYNERLIRAHSPNTVSHFYNFYGSRFQYIIINSINILSKKSKFKMLKIMASLFSLRDESRKFLAAQYIDVYLSVLYDAVASDAKECQVTLMSILGQYTFQDPSIANMTISSGFIERTIRFAFTLMAFNPEDLMSYLPISLYNGFKLPTETIRNRRTIICFKDLCTIMSANTVPEELLSNEAIFNAIIESFSEFSNVLPLKRETKEHVEVENFDFSAFYFFFSSILIMTDGYTRSISLVKDAAFRKQIVLKLLDVAQTREFESLTNSRKAISPDNASTNENDSNKATLSTVRETICNYVAETINFQVGVNTQYFFNPMSYLFKFVIQWSQCGRYEPIPASLTNYINLFEVFQDKQKALYISESALSTLVLIGQINVGFWVRNGTPITHQARMYTK-YSMREFTYISDIFNVQFSMAMCNPDELMVTYLSRWGLKHWANGVPMY------DYPDTETTVAVVNECILLLIQLLTEVRSLVMKSSKEG-FERTFKSEIIHALCFDTCSYAQIVNCIPEHIT--KHPSFDIYLEKYANYTSPVSLTDNGIFVLKEKYKDEIDPYYIGLSSSRRYDVEKNIRLNMANLKKMKYEDTFVPAKKVKDLLKNTLFSGLYSISSVNTFGLFLKNTLDHIIKYDYDNLLPRVVHLIHLCVVNNLNEFMGILWHEYAIVDTEFCHYHSIG-------SILYYCLLKDNFSESHGKIREIFRYLMETAPHVNVNSYLREQTTSYTPG-ILWPTKEDKSHKDKEFERKKHLARLRKKKLMKKLAQQQMKFMENNSVDTSDISTPRTTSP-------SLSPTRINAENSSNTINSCCDDDCVFCKMPKDDDVFVYFSYQERNICDHGIDFTNPTDVNRINSLFSGKQTKDSAIQENPQDDDGTRLKFTSCEPVLRACGHGSHTKCLSGHMKSIRGIQNQTTKNIP---LSYGSGLIYCPVCNS-LSNSFLPKTNDIDKRTSSQFFMCIEKRSEAEENLDPMSSICIKAAMILGDLQGKKVTTIEDAYKVVNSVFINTISNTELRLRSHKKEGKIVNMERISSQCILTLHLVCELKSFIYKKFVNSKTFSSE-----------------ISRKIWNWNEFLIKGNNVNLLLYMSQNFDNIDGGKTPQPPNLCIYEMFKR----------------------------------------------------RFHQLLLLLARDMMRVNFYKDCRNKIKISSNGSEEPSTSFSYLFNTFKKYVDLFKPDD----------VRFDFTSLEKIKDFICSL------------------------------------------------------------LLESLSIFCRRTFLLFNIQYDDDGDGDNNNNRSNNFMDVKQREIELIFRYFKLPNLTHFLKDFFYNELTQNIERYNDGNDNLRIQQVIYD-----MVQNINTRAYPSPEHIQLIELPLNLSKFSLDNDEISNKCDKYEIAVCLLCGQKCHIQKSIALQGYLQGECTDHMRNGCEITSAYGVFLMTG--TNAIYLSYGKRGTFYAAPYLSKYGETNEDYKFGTPVYLNRARYANLANEIVFGNMIPHIVFRLTDGSADLG-GWETM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . : . :: * : .*. * * *. : :* **. . * * .: . *.*** *:: . : . : :: . . . : ::* : . :: : . :: . .: . . : : . . : : . : . : . : :: * : .:: : : :. : : : . * . : * . :: .:. . . . * . : : :: :.. : *: :*: : : :. : . . . : :. : : *:. : : : : * .: .*: . :* *** .: * * . .: : : : .:: * *: : :: : .: :: * . .: * :.. .:: : . :*: :: : : : .* .:*:: :* ..: . : . .. : * . .. . :: . : .*:: . :: : . : : :. . . :.: . * :: ::: :: * .*:. : : . . . : : :. . : . .*.* * * :. . . . ..: *. .: : .: : :: . : :. : . :. . . : *: . : . : . :: . : . .. . . : :: : . : : . . :. . :. .. : . . :. . *: : : : : . . * ", "identical_positions": 52, "similar_positions": 295, "identity": "2.46%" }, { "cls_id": "homologset.agr.HGNC:16809", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZUV2-1", "uniprot_id": "A0A8I5ZUV2_RAT", "id": "A0A8I5ZUV2-1", "name": "E3 ubiquitin-protein ligase SMURF2", "aln": "MGLGRDTRAPCVPRGVRPSSGALGAGDLAHNPAPETALPTTNPALQQAPPPSPPRPQEPTSGGGGGGGGGGSGPRTGFPQTRGRAEEEAAEHPPASADFAPSAPRPRGTEKGRPRRAARTGGGGGARRRRRGRPRLPLCCAARAEEAEVGGGGSSASRSLRGSWRRRSAHPGPSGPGGRGAGCSDPGPGRCGDSSAPRRRPSPAQPARPRAASAAAAAASPAAGDMSNPGG-RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDR---------IGTGGQVVDCSR--LFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRP--------------------------------------------------------------------ASEYSSPGRPLSCFVDENTPITGTNGATCG-------------------QSSDPRLA--ERRVRSQRHR------------------NYMSR-------------------------------------------THLHTPP------------------------------------------------------------------------------------------------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLS--NINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLN------------------RQNQLKDQQQQQVVS-LCPDDTECLT--------------------------VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTPDSNVVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQ-IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A5Z6-1", "uniprot_id": "SMUF2_MOUSE", "id": "A2A5Z6-1", "name": "E3 ubiquitin-protein ligase SMURF2", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNPGG-RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDR---------IGTGGQVVDCSR--LFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRP--------------------------------------------------------------------ASEYSSPGRPLSCFVDENTPITGTNGATCG-------------------HSSDPRLA--ERRVRSQRHR------------------NYMSR-------------------------------------------THLHTPP------------------------------------------------------------------------------------------------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLS--NINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLN------------------RQNQLKDQQQQQVVP-LCPDDTECLT--------------------------VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQ-IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HAU4-1", "uniprot_id": "SMUF2_HUMAN", "id": "Q9HAU4-1", "name": "E3 ubiquitin-protein ligase SMURF2", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNPGG-RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDR---------IGTGGQVVDCSR--LFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRP--------------------------------------------------------------------ASEYSSPGRPLSCFVDENTPISGTNGATCG-------------------QSSDPRLA--ERRVRSQRHR------------------NYMSR-------------------------------------------THLHTPP------------------------------------------------------------------------------------------------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLS--NINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLN------------------RQNQLKDQQQQQVVS-LCPDDTECLT--------------------------VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQ-IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A9JRZ0-1", "uniprot_id": "SMUF2_DANRE", "id": "A9JRZ0-1", "name": "E3 ubiquitin-protein ligase SMURF2", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNQGV-RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKSDSITISVWNHKKIHKKQGAGFLGCVRLLSNSINRLKDTGYQRLDLNKLGPNDSDTVRGQIVVSLQSRDR---------IGSGGPVVDCSR--LFDNDLPDGWEERRTASGRIQYLNHITRSTQWERPTRP--------------------------------------------------------------------ASEYSSPGRPLSCLVDENTPIMTPNGAAGV-------------------PADDPRVQ--ERRVRSQRHR------------------NYMSR-------------------------------------------THLHTPP------------------------------------------------------------------------------------------------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLS--NVNCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNP--SPNGSRAAVEAQSSSRPGQLKEQAQSVVSPGNLPEDPECLT--------------------------VPKYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDNDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKHCTPDSNIVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQG---AAGPRLFTIHQ-IDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAVE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V853-1", "uniprot_id": "SMUF1_DROME", "id": "Q9V853-1", "name": "E3 ubiquitin-protein ligase Smurf1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKLDYPRRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.: . ****. *:*:*:***:**.:**:********** ***:** :**: :.:****** ****::* .*::**:***::**** *:*******: : *: **.:*:***** **.*:*.: *****::** *:* :*..* * . *. ::.**:******* .**: *:** *::***:** :* ..* :** *:*. . .. .*.:: : . *: :.:*:: :*: **:. * ::** *** *** ********** * **********:***:. ::. : :****.*** *:**:*********************..: ::. . . * . * . * :*:*:**** **: ** **. ***:****:****:******** :****.**: ****:**:***************:***:***** ********** *********.***:********** :*:****** :***** *******.*.***.*:* ******.**.*:*:.:*:*::: **.**:*::* :: *****.* ****.::.*:***:****:**:**** ********* *:**.***:.***:****:: *:..**:.**: ******** ::. * ***:.** :..* *******************:**** *.******** *. *:*************:****:*: * :** *:*********", "identical_positions": 458, "similar_positions": 181, "identity": "35.56%" }, { "cls_id": "homologset.agr.HGNC:1681", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P26051-1", "uniprot_id": "CD44_RAT", "id": "P26051-1", "name": "CD44 antigen", "aln": "-MDKVWWHTAWGLLCLLQLSLAQQQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALRKGFETCRYGFIEGHVVIPRIHPN-AICAANNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEG-YILHTDLPTSQPTGDRDDAFFIGSTLATIA---------------------------------------------------------------------------------------------------------------------------TTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQDEEETPHATSTTWADPNSTTEEAATQKEKWFENEWQGKNPPTPSEDSHVTEGTTAS-AHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQT-ESK------------------------------------------------------------------------------------------------------------------------------------------------------------GHSSGNQDSGVTTTSGPARRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEASKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P15379-14", "uniprot_id": "CD44_MOUSE", "id": "P15379-14", "name": "CD44 antigen", "aln": "-MDKFWWHTAWG-LCLLQLSLAHQQIDLNVTCRYAGVFHVEKNGRYSISRTEAADLCQAFNSTLPTMDQMKLALSKGFETCRYGFIEGNVVIPRIHPN-AICAANHTGVYILVTSNTSHYDTYCFNASAPPEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDDDVSSGSTIEKSTPEG-YILHTYLPTEQPTGDQDDSFFIRSTLATIASTVHSKSHAAAQKQNNWIWSWFGNSQSTTQTQEPTTSATTALMTTPETPPKRQEAQNWFSWLFQPSESKSHLHTTTKMPGTESNTNPTGWEPNEENEDETDTYPSFSGSGIDDDEDFISSTIATTPRVSARTEDNQDWTQWKPNHSNPEVLLQTTTRMADIDRISTSAHGENWTPEPQPPFNNHEYQDEEETPHATSTT---PNSTAEAAATQQETWFQNGWQGKNPPTPSEDSHVTEGTTAS-AHNNHPSQRITTQSQEDVSWTDFFDPISHPMGQGHQT-ESKDTDSSHSTTLQPTAAPNTHLVEDLNRTGPLSVTTPQSHSQNFSTLHGEPEEDENYPTTSILPSSTKSSAKDARRGGSLPTDTTTSVEGYTFQYPDTMENGTLFPVTPAKTEVFGETEVTLATDSNVNVDGSLPGDRDSSKDSRGSSRTVTHGSELAGHSSANQDSGVTTTSGPMRRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINGGNGTVEDRKPSELNGEASKSQEMVHLVNKEPSETPDQCMTADETRNLQSVDMKIGV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P16070-1", "uniprot_id": "CD44_HUMAN", "id": "P16070-1", "name": "CD44 antigen", "aln": "-MDKFWWHAAWG-LCLVPLSLA--QIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPN-SICAANNTGVYILTS-NTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYT-FSTVHPIPDEDSPWITDSTDRIPATTLMSTS-----------------------------------ATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVG-DSNSNVNRSLSGDQDTFHPSGGS--HTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F6T0-1", "uniprot_id": "E7F6T0_DANRE", "id": "E7F6T0-1", "name": "CD44 antigen", "aln": "MWTLLFVVFATGSPAVLQAAPVQGNSGR---CSFAGVFHIEGISRYSLTFQKAGELCQSLGYRLATQEQVTEAYKKGLRTCRYGWIDGQNVTFLPHINGPNCDSSSAEITFHAKAGEFLSDVYCFDPSDSSP------------------------------------------NCDDVKSEDVMNGN-----------------------AARDSSFYAKP-----------------------------------------------------------------------------------------------------------------------------------------------HEDFITEFKTEGFLVDVEEILERVKR--ETSLLSDMKPSTVPSMKNIEGIKD-------------PTSKPHIGKTPSVLLFDTEGSGSGLVDP-EPSHFTTSPVTTETAKSNLIENVIEENEEMVVPVETSNVNPIQVKEPRRV---------------------------------------------------------------------------------------------------------------------------------------------------------------NVFSTTESNAKEMVSDGSS-----STWMIITAFCVFIGVIVCIFVAIGTRDKWYGPSKSADITTEKNNKDYSKTETLPLSEKEQEIVALMNVTNMKNGQTVDITAADEHEKEYLM----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: * * .:: : . : . * :*****:* .***:: :*.:**:::. *.* *: * *:.*****:*:*: * * * . * :. : : : . *.***:.* . .: .:** .*. .*..: . :: . ... .*::. : :.* :: : . .. *.: : * .: *.*... * . * . * * ** * ...:: : ..: : . * .: : . : . ::. .* ..:. .:.*. . *:** * : :.:*:.: :*:.:* : .* . : :* . : :.*.**:* *:* :. : : .: :. * ", "identical_positions": 72, "similar_positions": 142, "identity": "9.15%" }, { "cls_id": "homologset.agr.HGNC:16810", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BXT1-1", "uniprot_id": "RGS8_MOUSE", "id": "Q8BXT1-1", "name": "Regulator of G protein signaling 8", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALLMPRRNKGMRTRLGCLSH--KSDSCSDFTAILP---DKPNRALKRLSTEE---------ATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKK-----------------------------------TRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPS----------------------------------------------------------------------------------------------------------------------LTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQ---RRLS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P49804-1", "uniprot_id": "RGS8_RAT", "id": "P49804-1", "name": "Regulator of G protein signaling 8", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALLMPRRNKGMRTRLGCLSH--KSDSCSDFTAILP---DKPNRALKRLSTEE---------ATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKK-----------------------------------TRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPS----------------------------------------------------------------------------------------------------------------------LTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQ---RRLS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P57771-1", "uniprot_id": "RGS8_HUMAN", "id": "P57771-1", "name": "Regulator of G protein signaling 8", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALLMPRRNKGMRTRLGCLSH--KSDSCSDFTAILP---DKPNRALKRLSTEE---------ATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKK-----------------------------------TRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPS----------------------------------------------------------------------------------------------------------------------LTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQ---RRLS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DGI0-1", "uniprot_id": "RGS8_DANRE", "id": "Q6DGI0-1", "name": "Regulator of G protein signaling 8", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTRLGCLSN--KSDSCSDFSEFLPPAQERTTRCLK-LSNDE---------VTRWADSFDILLSNKYGLAAFRTFLKTEFSDENIEFWLACEDYKK-----------------------------------IKSPAKMMSKANKIYKEFIDVHAPREVNIDHRTREETKNRLLEPT----------------------------------------------------------------------------------------------------------------------PHSLNEVQAKVYSLMEKDSYPRFIRSKIYQDLLNRTQIYCQRKSV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P11972-1", "uniprot_id": "SST2_YEAST", "id": "P11972-1", "name": "Protein SST2", "aln": "MVDKNRTLHELSSKNFSRTPNGLIFTNDLKTVYSIFLICLDLKEKKHSSDTKSFLLTAFTKHFHFTFTYQEAIKAMGQLELKVDMNTTCINVSYNIKPSLARHLLTLFMSSKLLHTPQDRTRGEPKEKVLFQPTPKGVAVLQKYVRDIGLKTMPDILLSSFNSMKLFTFERSSVTDSIIHSDYLIHILFIKMMGAKPNVWSPTNADDPLPCLSSLLEYTNNDDTFTFEKSKPEQGWQAQIGNIDINDLERVSPLAHRFFTNPDSESHTQYYVSNAGIRLFENKTFGTSKKIVIKYTFTTKAIWQWIMDCTDIMHVKEAVSLAALFLKTGLIVPVLLQPSRTDKKKFQISRSSFFTLSKRGWDLVSWTGCKSNNIRAPNGSTIDLDFTLRGHMTVRDEKKTLDDSEGFSQDMLISSSNLNKLDYVLTDPGMRYLFRRHLEKELCVENLDVFIEIKRFLKKMTILKKLIDSKHCDKKSNTSTSKNNIVKTIDSALMKQANECLEMAYHIYSSYIMIGSPYQLNIHHNLRQNISDIMLHPHSPLSEHFPTNLYDPSPASAESAASSISSTEADTLGEPPEVSLKPSKNLSNENCSFKKQGFKHQLKEYKPAPLTLAETHSPNASVENSHTIVRYGMDNTQNDTKSVESFPATLKVLRKLYPLFEIVSNEMYRLMNNDSFQKFTQSDVYKDASALIEIQEKC---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : ** *: :: . * : :. . . * * :. : :.:* :*:. ** .*:.*:. **::.:: : : * :.. : : * :*:..:: : :* ::**... *: . : .* :: .. ::: **::**: :* :*.:* * : : ", "identical_positions": 30, "similar_positions": 70, "identity": "4.28%" }, { "cls_id": "homologset.agr.HGNC:16811", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K6I6-1", "uniprot_id": "A0A0G2K6I6_RAT", "id": "A0A0G2K6I6-1", "name": "Tubulin delta chain", "aln": "MSIVTVQLGQCGNQIGFEVFDTLFRDSHCSQGLCSKRENEAYQASCKERFFREEENGVPVARAVLIDMEPKVINQTLSKAAQSGRWKYGQHTSFCQKQGSGNNWAYGYSVHGPKHEESIMNLIQTEVEKCDSLSGFFIIMSMAGGTGSGLGAFITQKLQDQYSSSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLIHENDVVHKICAKRMNIKQISFRDLNRVLAHQLGSVFQPTHSEDSSFHYCRNPLGDLMEHLVPHPEFKMLGVRNIPQMSAESLAYSTFTWAGLLKHLRQMLISRAKMEEGIDWQVRPPLSGLPPIGKASAHKEPHFNTSLANLVILRGREVHSADVGGFRDAALYTSWLEPADAFSVWKTPRPFDKYEKSAALVSNSQLLVKPLDMVVGKAWNMFSSKAYIHQYTKFGMEEEDFLDSFTLLEQVVASYGSLP-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R1K7-1", "uniprot_id": "TBD_MOUSE", "id": "Q9R1K7-1", "name": "Tubulin delta chain", "aln": "MSIVTVQLGQCGNQIGFEVFDALFRDSHCSQGLCSKRDNEAYQASCRERFFREEENGVPVARAVLVDMEPKVINQTLSKAAQSGRWNYGQHTSFCQKQGSGNNWAYGYSVHGPKHEESIMNLIQTEVEKCDSLSGFFIIMSMAGGTGSGLGAFVTQKLQDQYSSSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLIHENDAVHKICAKRMNIKQISFRDLNQVLAHQLGSVFQPTYSEDSSFHYRRNPLGDLMEHLVPHPEFKMLGVRNIPQMSAASLAYSAFTWAGLLKHLRQMLISSAKMEEGINWQVRPPLTGLPPIGKASAHKEHHFNTSLANLVVLRGREVHSADVEGFKDPALYTSWLEPVDAFSVWKTQRAFDKYEKSAALVSNSQLLVKPLDMIVGKAWNMFSSKAFIHQYTKFGMEEEDFLDSFALLEQVVASYGSLGP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJT1-1", "uniprot_id": "TBD_HUMAN", "id": "Q9UJT1-1", "name": "Tubulin delta chain", "aln": "MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQASCKERFFSEEENGVPIARAVLVDMEPKVINQMLSKAAQSGQWKYGQHACFCQKQGSGNNWAYGYSVHGPRHEESIMNIIRKEVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLEDQYSNSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLLHENDAIHKICAKLMNIKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRNIPHMSENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNKDLHFNTSIANLVILRGKDVQSADVEGFKDPALYTSWLKPVNAFNVWKTQRAFSKYEKSAVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASYCNL--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********************:*: ***.****** *:********:**** *******:*****:********* ********:*:****:.********************:*******:*:.*******:********************:**:*:****.**************************************:****.:****** ******** *:*:*************:* :***** ********************.*****:** ****::**************** *******: :* ***:****:.* * :*: *****:****:***::*:**** **:*.*******:*.:**.**** *.*.******.******:*******:********:***:********:*********: ******** .* ", "identical_positions": 374, "similar_positions": 59, "identity": "82.2%" }, { "cls_id": "homologset.agr.HGNC:16812", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BJQ0-1", "uniprot_id": "COQ8A_RAT", "id": "Q5BJQ0-1", "name": "Atypical kinase COQ8A, mitochondrial", "aln": "MAAMLGDAIMVAKGLAKLTQAAVETHLQN--------------LGLGGELILAARALQSTAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVG--------GLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTG-KKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFA--SEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYC--RMKSGLQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q60936-1", "uniprot_id": "COQ8A_MOUSE", "id": "Q60936-1", "name": "Atypical kinase COQ8A, mitochondrial", "aln": "MAAMLGDAIMVAKGLAKLTQAAVETHLQN--------------LGLGGELLLAARALQSTAVEQFSMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGTSLDFSAASSLDQSLSP----SHSQGPAPAYASSGPFREAGLPGQATSPMGRVNGRLFVDHRDLFLANGIQRRSFHQDQSSVG--------GLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKSLRSENSTG-KKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNSDLGPHWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFA--SEEPFDFGTQSTTEKIHNLIPVMLKHRLIPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYC--RMKSGLQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NI60-1", "uniprot_id": "COQ8A_HUMAN", "id": "Q8NI60-1", "name": "Atypical kinase COQ8A, mitochondrial", "aln": "MAAILGDTIMVAKGLVKLTQAAVETHLQH--------------LGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFA-ENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVG--------GLTAEDIEKARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSG-KKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFA--SDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYC--KRQAQQ-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5RGU1-1", "uniprot_id": "COQ8A_DANRE", "id": "Q5RGU1-1", "name": "Atypical kinase COQ8A, mitochondrial", "aln": "---MAGDMLLLMRGLARLSQAVIETQANS--------------LRSG-----GVQTMQMTAEQAMGVAMQKIQEFTGSQQSVS-DFSADMDSKYDFTASEQNFES---AAHGGLD--------------------SDSVFRDANTGAANTYSQAQGKSKLFDGYKDPTSQFTGHTRSYHQDHSSVG--------GITAEDIEKAREAKQN-GSKPHKQMLSERARERKVPVTRLGRLANFGGLAVGLGIGALAEVAKKSLRSEDKNGNKKAVLDSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPQLAKIFERVRQSADFMPIKQMTKALSNDLGPNWRDKLEMFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAQSINSDVNNLMTVLSMSNALPEGLFPEHLIDVMRRELALECDYIREAKCARKFKELLKDHPFFYVPDVISELSSQHVLTTELVPGFPLDQAEALTQELKNEICKNILNLCLRELFEFRYMQTDPNWSNFFYDPQTHRVALLDFGATRGFDESFTDVYIEIIKAAADGNREGVLKQSIDMKFLTGYESKAMVNAHVDAVMILGEAFA--SEEPFDFGAQSTTERIHNLIPVMLKQRLIPPPEETYSLHRKMGGSFLICSRLNAKISCKDMFEAAYSNYWSGRKKGPSQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7F0M3-1", "uniprot_id": "E7F0M3_DANRE", "id": "E7F0M3-1", "name": "Atypical kinase COQ8A, mitochondrial", "aln": "MVKMAAD-MLLMRGINRFRNIRFRGRQK-----------------------------------QVSFLTPQLRGQVSCG----------HQTALSFSG-------------------------------------VMGVFGSD-------QHLSRLFGKIHPDQQHIYSQIG----FFHQDHRYYS--------ALKKEGVKG-----VKADSRKHNQKLSESARERKMPVTRIGRLVNFGGLAVGLGIGAIAEVAKKSFASRDNSGQKKAILDSNPFISEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPQLAKIFERVRQSADFMPAKQTMKMVVSDLGPNWQDHLEYFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAKSISSDINNLLTLLSISHALPEGLFPEHLIEVMSRELALECDYIREAKCAKKFQQLLKGHPFFSVPNVVDELSSKHVLTTELVSGFPLDKAEDLPQELKNEICEQILILCLRELFEFRYMQTDPNWSNFFFDPQTHKVALLDFGATRGFDASFTDTYIEIIKAAADRNREGVLQRSIDMKFLTGYESKSMVNAHVDAVMILGEAFS--SDEPFDFGSQSTTERIHRLIPVMLKERLTPPPEETYSLHRKMGGSFLICSRLKAQICCKNMFQEAYAKYWRERHKETAQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P27697-1", "uniprot_id": "COQ8_YEAST", "id": "P27697-1", "name": "Atypical kinase COQ8, mitochondrial", "aln": "------------------------------------------MVTNMVKLRNLRRLYCSS------RLLRTIQN--------------------------GRISSVSSISLSKKYTTKSAK-----------------EGEENVERKHEEE----------------KKDT----------------------------------------------------LKSSSVPTSRISRLFHYGSLAAGVGMNAAAKGIS-EVAKGNSPTWKSLIL------SDSNIDRITNKFSKMRGVALKIGQLLSFQDEKVLPKELYEILSRVQNSANHMPQRQLEKVMAKELGANWKTKFSKFDKIPMAAASIGQVHAAELPSGQRVVVKIQYPGVKESIDSDLNSLLMLLTASSLLPKGLFLDKTIANARTELKWECDYNREARALQKFEALLKDDPAFEVPHVFPEYTTDNIITMTRMEGTEIMKLPKASQETKNFISENIMRLCLEEIATFKYMQTDPNWANFLYNGRTKKIELLDFGASRPFAEDFILKYRKLLTYATLRDRKGAYEMSVQLGYLTGLESQSMKDAHVDSVLTLGEPFRGDVDKSFDFKDQTVSDRIRGNIGLMLNERLCPPPEETYSLHRKFSGIFLLCARMGASVHCAKLFKEIFAYKV---------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VYI6-1", "uniprot_id": "Q9VYI6_DROME", "id": "Q9VYI6-1", "name": "", "aln": "MSRSAQEAAALLRGLRILLEACGREHLAHGRHLWSNSSIRELIAENVAHTQQLVRSSSQNPTEELKKLQQTVKETGERGYVVAKGICSLLETKIKMSREESAISEPAQVSSIRKSTPTAQNPASWDAANLDISSITLQEFEEILSRRNKDRSVSLRTPATKSNQTMPKKETSTNPGIITQDTEYVNNVLRFVAGAKVEEQPPDAQPKKKSDQPAIEVPELSKVAKQRKVPSSRIGRMASFGGLFAGLGLGTLNELTKGALGLGGSTSMREALL------SPANAERIVDTLCKVRGAALKIGQILSIQDSSVVSPQLAKAFERVRQAADYMPDWQVERVMNTQLGADWRQRLKSFEDKPFAAASIGQVHRATLSDGMDVAIKIQYPGVAQSIESDIDNLVGMLKVWDVFPQGFFIDNVVRVAKRELQWEVDYDREAEYTEKFREMIAPYPEYYVPRVVRDLTTSSVLTTELVPGVPLDKCFDLSYEHRRHIAASVLKLCLRELFEIECMQTDPNWSNFLYDAPSRRLMLIDFGSTRFYRHEFIRNYRRVIMSAAENNRQGVLEMSREMGFLTGYETKQMEQAHVDAVMILGEIFR--YDGDFDFGRQNTTERLAALVPTMVAHRLCPPPEEIYSIHRKLSGIFLLCARLNVRMNCVPFYKDIVLGKFKD-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: . :. .:* :*:.*: :*.* .*:*:.: : . . . :. :* * :* :**. .:.*:**.***:**:**:**. .: .* : :.**:::*:.** * : : .:**..*: ::. *:. *:********* * : .* *.:******* :**.**::.*: :*. :*:*:* :: : ** * ** *** .**. :: * : ** :. : : ::* : * : : . * :. *. .:: ***.*: :. *******:**::: ::: *:***::* : .* * .:: *: :*: . * :: :*** * : * :**:*::: *** * : *** *..:::: : *: .** ***** **:***:.* **:*::: . . * ::: ", "identical_positions": 138, "similar_positions": 154, "identity": "20.41%" }, { "cls_id": "homologset.agr.HGNC:16813", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D119-1", "uniprot_id": "PPR27_MOUSE", "id": "Q9D119-1", "name": "Protein phosphatase 1 regulatory subunit 27", "aln": "-------MPSRTVRYARYSPRQRRRR-------------------------------------------------------------------MLADRSVRFPN-------DVLFLDHIRQGDLEQVGRFIRAR-KVSLDTIHPS-GLAALHEAVLSGNLE------CVKLLVKYGADIHQRDETGWTPLHIACSDGYPDIARYLISLGADRDAANDDGD--LPSDLIDPDFKDLVELFKGTSMD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZXG0-1", "uniprot_id": "D3ZXG0_RAT", "id": "D3ZXG0-1", "name": "Protein phosphatase 1 regulatory subunit 27", "aln": "-------MPSRTVRYARYSPRQRRRR-------------------------------------------------------------------LLADRSVRFPN-------DVLFLDHIRQGDLEQVGRFIRAR-KVSLDTIYPS-GLAALHEAVLSGNLE------CVKLLVKYGADIHQRDETGWTPLHIACSDGYPDIARYLISLGADRDATNDDGD--LPSDLIDPDFKDLVELFKGTSMD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q86WC6-1", "uniprot_id": "PPR27_HUMAN", "id": "Q86WC6-1", "name": "Protein phosphatase 1 regulatory subunit 27", "aln": "-------MPSRTARYARYSPRQRRRR-------------------------------------------------------------------MLADRSVRFPN-------DVLFLDHIRQGDLEQVGRFIRTR-KVSLATIHPS-GLAALHEAVLSGNLE------CVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDATNDDGD--LPSDLIDPDYKELVELFKGTTMD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N852-1", "uniprot_id": "A0A8M1N852_DANRE", "id": "A0A8M1N852-1", "name": "", "aln": "-MLKFFLCPVTQTM--HYGICNPNTTDPLSCS--------------------------------------------RSQSS------------IKSARIVHFPN-------DIVFQDCVRQGELERVGCFIQTR-RVSLDTIYHS-GMAAIHEAVLSGNME------CVKLLVKSGADITQRDEDGWTPLHMACSDGFPEIAKYLISLGADTEAKNDCGE--KPADLIDPDCKELLHLFGVGGD-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A2R8QPQ5-1", "uniprot_id": "A0A2R8QPQ5_DANRE", "id": "A0A2R8QPQ5-1", "name": "", "aln": "-MKYSYQYPVSQYTRPHYTSSTQYTPSHYSSSSYSPSYYSSSKYSPTTLHTRKYYTPPAYTPAYKPTYTSVCSKTSRPSSSPRTAVQITPSVTLKPARAVRFTN-------DVVFQDLVRHSELEQIGRFMRAR-KVRLDTIFHS-GMAALHEAVLSGSLE------CVKLLIKYGADVHQRDENGWTPLHMACSDGYPEIAKYLLSLGASVEAENENGE--KPADLIDPDCKELLKLFETGCV-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53066-1", "uniprot_id": "YGZ2_YEAST", "id": "P53066-1", "name": "Ankyrin repeat-containing protein YGL242C", "aln": "MNTEGASLSEQLLDAARRNNLDLLETVFDSLD-------------------------------------------------------------NDPEKIAKLINESKEPLGNTALHLCCKYGSWEVLDKILDQDGEIEIDPQNDVDGDTPLHVTVRYSQEEPEHGTFIARNLIEVGADPRVRNYNNQKPVDLVHGDELDELIDLLQGAELAIDSTNGSGDNNEDGEMIDDGPSDDDEEDDKK---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . : .:: * : : : .. * :. :: .: : . * :.:* :* .. * .: *:: *** *: . .*:.:. .* :: * . :: * *: .::** . .: . ", "identical_positions": 18, "similar_positions": 51, "identity": "7.35%" }, { "cls_id": "homologset.agr.HGNC:16814", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LX95-1", "uniprot_id": "F1LX95_RAT", "id": "F1LX95-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------MAVSAPP-VISATSTSAGVPGGLFRAEP---------------------LYSSPGEPPRLTPNMIN----------------------SFMASNHNGSVVGGGIGGGSGGTSNTNTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQM---TRKQAVNSSRPGRPPKRSLG-VLQDNARLLPH--------------------------------------------------AVPGLLSPGLITP---TGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSTTGGSESSWDKEKIQSPLAAPGAQHGIAHAALAGQ-PGLGGAPTLNPLQQNHLLSNRLDLPFMMMP-------------HPLLPVSLPPASVAMAMNQMNHLN---------TIANMAAAAQIHSPLSRAGASVIKERIPESPSPAPSLEESHRPGSQTSSHPSSSVSSSPSQMDHQSERMVMMPNNREEIIIDQDNGQSIKKFQRDNKDIQLSQHHLLNTFLHWIELAPL--------SKKSLLHQKEVPAQIPMMKSPLDKIQLAPGQALPPGFPGPFIFADSLSSVETLLTNIQVNNISINKINGLLKVALDNARIQEKQIQQEKKELRIELYREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFESKRRE------------------------------QVEQALKQATSGDSGLRMLKDSGIPDIEIENSGTPHDSAAMQGGNYYCLAMAQQLCSA--------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q925Q8-1", "uniprot_id": "DACH2_MOUSE", "id": "Q925Q8-1", "name": "Dachshund homolog 2", "aln": "--------------------------------------------------------------------------------------------------MAVSAPP-VISATSSSAGVPGGLFRAEP---------------------LYSSPGEPPRLTPNMIN----------------------SFMANNHNGSVLGGGIGGGSGGSSNTNTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQM---TRKQAVNSSRPGRPPKRSLG-VLQDNARLLPH--------------------------------------------------AVPGLLSPGLITP---TGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSTTGGSESSWDKDKIQSPLAASGPQHGIAHAALAGQ-PGLGGAPTLNPLQQNHLLSNRLDLPFMMMP-------------HPLLPVSLPPASVAMAMNQMNHLN---------TIANMAAAAQIHSPLSRAGASVIKERIPESPSPAPSLEESHRPGSQTSSHPSSSVSSSPSQMDHHSERMVMMPNNREELIVDQDNGQSIKKFQRDNK--------------------------------------EEVPAQIPVMKSPLDKIQLAPGQALHPGFPGPFIFADSLSSVETLLTNIQG----------LLKVALDNARIQEKQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFESKRRE------------------------------QVEQALKQATSGDSGLRMLKDSGIPDIEIENSGTPHDSAAMQGGNYYCLAMAQQLCSA--------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96NX9-1", "uniprot_id": "DACH2_HUMAN", "id": "Q96NX9-1", "name": "Dachshund homolog 2", "aln": "--------------------------------------------------------------------------------------------------MAVSASP-VISATSSGAGVPGGLFRAEP---------------------LYSTPREPPRLTPNMIN----------------------SFVVNNHSNSAGGGGRG-------NTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQM---TRKQAVNSSRPGRPPKRSLG-VLQENARLLTH--------------------------------------------------AVPGLLSPGLITP---TGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQ-PGIGGAPTLNPLQQNHLLTNRLDLPFMMMP-------------HPLLPVSLPPASVAMAMNQMNHLN---------TIANMAAAAQIHSPLSRAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERM------------------------------------------------------------------EEVPVQIPIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQG----------LLKVALDNARIQEKQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRRE------------------------------QVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA--------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T9A7-1", "uniprot_id": "A0AB32T9A7_DANRE", "id": "A0AB32T9A7-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------MAVSATPPVLSPTSTPGGAS--LFRPDS---------------------LYSSPAESPRLTSSMIN----------------------SFITG--GGSTNGNGPG-------GVHNNECKMVEVHGVKVASFTVDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDICPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLYNDCTNA----------------SSRPGRPPKRSLGVAMQDSSRLLPH--------------------------------------------------SVHGLLSPGLLSP---TGLTAAAMAEAMKLQKMKLMAMNNIHGAGSQNGTESENEELNSSAGGSESSWDKEKLQSPPSS-GAQHGLAHAALSAQ-HGLSGS-HLSSLQQSHLLANRLDLPFMMMP-------------HPLLPVSLPPASVAMAMNQMNHLN---------TIANMAAAAQMHSPLSRAGASVIKECVQDSPSPTPSLEEAPRPGSQPSSHPSSSVSSSPNPHTQSPERLVLNPTDGDLP--ERDTGINMKKMLKEK---------------------------------------DEAQITLPMQKPGFEKLPLGT-QTLPPGFPAPFLFADGLSSVETLLTNIQAAQG-------LLKVAVDNARVQEKQVQQERKELKMELYREREMRESLERQLTSELHSRATIQKRLKKEKKAKRKLQEALEFESKRRE------------------------------QVEQALKQATSPESLRMSLNEAVIPEVKSEHNGNQQENSSVQENRPYSKPPIMY------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IP19-1", "uniprot_id": "Q8IP19_DROME", "id": "Q8IP19-1", "name": "", "aln": "MDSVTSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPESNSLQFRSSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGP-LGIDAHAAVPASSTETLLRNIQS----------LLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMKENDAGSEKSDKSLASNSSCDVTAGHSAGSVSGSISAGLNCPDSPTHFKREPSSDHEGSVERQPRSSAASLAAHDEDNTKRCGSRDRDERPPSGSAASVAAEGSLAAAAAAAAAAAAAAASNGKGPWSYPGIDLMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSAN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * * .:*..*: :: : : * .. *.. * : .::. . . . ***::*: :* ***:* :..: ::****.*:********************** *:**.**********************: ***: *: ***.* **********. ::* * .. .*:***: . : : : * : *. *: : * :. .: ::: . ... .:: *: . . . :.:. :: : .: .. :*. :* . *.: . .* :: .. . :. * .: : .. ** . * :.* . . * * . .: .:: .:::.:::. : . . : * :* . : * **.**** *** ***** **** **:*:. *: **:::: ****:::.*****. * : * ***:::*:* : : *: * * : : :: :: .. :. : : :: :. *. :.. :: . ", "identical_positions": 155, "similar_positions": 178, "identity": "14.19%" }, { "cls_id": "homologset.agr.HGNC:16815", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V6P4-1", "uniprot_id": "G3V6P4_RAT", "id": "G3V6P4-1", "name": "Phosphoethanolamine/phosphocholine phosphatase", "aln": "MPWPGERGSHHLLKPHCFSCCLLASDSGRNPTCWSWMCQRPWLWPANQPLPGRLPPR-RLSLAPSSCSSSPCSQDGRMAAPGAPRFLLTFDFDETIVDENSDDSIVRAAPGQQLPESLRATYREGYYNEYMQRVFKYLGEQGVRPRDLRAVYETIPLSPGMGDLLQFIAKQGS-CFEVILISDANTFGVESALRAAGHHSLFRRILSNPSGPDARGLLTLRPFHTHS-CSRCPANMCKHKVLSEYLRERARD--GVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRAHVVPWETAADVRQHLQQVLKMC---------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R2H9-1", "uniprot_id": "PHOP1_MOUSE", "id": "Q8R2H9-1", "name": "Phosphoethanolamine/phosphocholine phosphatase", "aln": "-------------------------------------------------MSGCFPAV-GLR-----CLS----RDGRMAAPGAPRFLLTFDFDETIVDENSDDSIVRAAPGQQLPESLRATYREGYYNEYMQRVFKYLGEQGVRPRDLRAVYETIPLSPGMGDLLQFIAKQGS-CFEVILISDANTFGVESALRAAGHHSLFRRILSNPSGPDARGLLTLRPFHTHS-CSRCPANMCKHKVLSEYLRERARD--GVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRAHVVPWETAADVRQHLQQVLKMC---------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TCT1-1", "uniprot_id": "PHOP1_HUMAN", "id": "Q8TCT1-1", "name": "Phosphoethanolamine/phosphocholine phosphatase", "aln": "-------------------------------------------------MSGCFPVS-GLR-----CLS----RDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGA-CFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHS-CARCPANMCKHKVLSDYLRERAHD--GVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DBV4-1", "uniprot_id": "PHOP1_DANRE", "id": "Q6DBV4-1", "name": "Probable phosphatase phospho1", "aln": "--------------------------------------------MRDSVFNCCVSPP-HPP-----GAAAAERRSRSPAPQNHSRFLMFFDFDETLVDECSDDSMVSAAPGGVLPGWLKDTYRPGRYNEYMQRVLAYLSEQGVTPAAIRATVEKLPPCPGIPALMHFLLSQPSRDFEVVCVSDANTVFIETWLQHMGFQPLFLRIFTNPAHFDDNGVLQLRPFHSHE-CLRCPANMCKAVVVRQYVAQRIRERGGRPYQKVLYMGDGANDFCPSLTLSPGDVAFPRRDFPMHKLIQEMGEAKPGEFKASVVPWKSGEDVVNTLRKILERT---------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VWF0-1", "uniprot_id": "Q9VWF0_DROME", "id": "Q9VWF0-1", "name": "Pyridoxal phosphate phosphatase PHOSPHO2", "aln": "-------------------------------------------------MSSNQEQSP---------AAVAAAVASCRLRKQQRRRLAAFDFDHTIVSQNTDTVVRDLLPTEVTSAKVNELVENDCWTEYMAEVFRLLHEQQVSEARIRDTIRGIPEVPGFVRLIKHLAKRLH--YDLIIISDSNSVFIDEWLRAHNLADCFVAIFTNPAEFDASGRLMVRAHHQQSDCKLSASNLCKGRVLEHFVIEQDLRR-SIRYDHVFYVGDGNNDICPVLRQRACDFACARKGFAMEKHLLRNRSK--LKLRAQLLIWKSGFDLMDQMLALPQLKTPQVQGDGDQPDQDADTDGKVPEVARRASAVAGPTKSPN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * * ****.*:*.: :* : * . :. . . :.*** .*: * ** * : . :* **: *::.: .: :::: :**:*:. :: *: . * *::**: * * * :*..* :. * ..:*:** *: .:: :: . :::::*:*** **:** *.* .*:.:.*.: : . . .::* :: *::. *: : : : ", "identical_positions": 55, "similar_positions": 88, "identity": "14.91%" }, { "cls_id": "homologset.agr.HGNC:16816", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZD32-1", "uniprot_id": "CHD5_RAT", "id": "D3ZD32-1", "name": "ATP-dependent chromatin remodeler CHD5", "aln": "MRGPLGTEEELPRLFAEEMENEE-------------------------EMSEEEDGGLEG------FEDFFPAEP-VSLPKKK-PKKLKESKS-KGKRKKKE----GSNDELSENEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKK---AKRKKRDEDEEDNEDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFK----GSSAAAAAAAVAAAVETVTIAPPLAIS-PQQVPQPLPVRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGIS-KRKKGSSSEEDEPED-SDLDN----------------ASIHSSSVRSECSAALGK---------------------KNKRR-RKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSE-KRKNKDPL-------YAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQTYWGHRELMLGEDARLPKRLVKKGKKLKD--DKQEK--------PPDTPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPMLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDVQSTKGGSLAAGAKKKHGGTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYND-------ASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPE--------------GPEGKKPGEVISSDPNTPVPASPAQLPPAPLGLPDKMEAQLGYTDEKESGTQKPKKSLEIQALPTALDRVEAEDKHQSSDSKDRAREERMEEVEKAQGSPEQ--PLKEETLPDKEPVPDKLELSLSHSN----------DFRPDDPKAEEKE-------------PTETQQNGD---REEDEEGKKEDKN-GKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDP----TIQQGAFGSSQMYNNSFGPNFRGPGPGGIVNYNQMPLGPYVTGR----------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A8L1-1", "uniprot_id": "CHD5_MOUSE", "id": "A2A8L1-1", "name": "ATP-dependent chromatin remodeler CHD5", "aln": "MRGPLGTEEELPRLFAEEMENEE-------------------------EMSEEEDGGLEG------FEDFFPAEP-VSLPKKK-PKKLKESKSSKGKRKKKE----GSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFK----GSSAAAAAAAVAAAVETVTIAPPLAIS-PQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGIS-KRKKGSSSEEDERED-SDLDN----------------ASIHSSSVRSECSAALGK---------------------KNKRR-RKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSE-KRKNKDPL-------YAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKD--DKQEK--------PPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYND-------ASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPE--------------GAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQ--PLKEEVLPDKEPIPDKPELSLGHSG----------DFRPDDPKTEEKE-------------PGETQQNGD---REEDEEGKKEDKN-GKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDP----TIQQTSSRRRDFP--LFQRSFPAEPSHLPNPRGREKLQPF--------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TDI0-1", "uniprot_id": "CHD5_HUMAN", "id": "Q8TDI0-1", "name": "ATP-dependent chromatin remodeler CHD5", "aln": "MRGPVGTEEELPRLFAEEMENED-------------------------EMSEEEDGGLEA------FDDFFPVEP-VSLPKKKKPKKLKENKC-KGKRKKKE----GSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKK---AKRKKKDEDEDDNDDGCLKEPKSSGQLMAEWGLDDVDYLFSEEDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFK----GSSAAAAAAAVAAAVETVTISPPLAVS-PPQVPQPVPIRKAKTKEGKGPGVRKKIKGSKDGKKKGKGKKTAGLKFRFGGISNKRKKGSSSEEDEREE-SDFDS----------------ASIHSASVRSECSAALGK---------------------KSKRR-RKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPDVEPSLPPPKPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSE-KRKNKDPL-------YAKMEERFYRYGIKPEWMMIHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDDIDIPYYDNLKQAYWGHRELMLGEDTRLPKRLLKKGKKLRD--DKQEK--------PPDTPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPVTPIPDVQSSKGGNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREIIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYND-------ASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLIPE--------------GPEGKKSGEVISSDPNTPVPASPAHLLPAPLGLPDKMEAQLGYMDEKDPGAQKPRQPLEVQALPAALDRVESEDKHESPASKERAREERPEETEKAPPSPEQ--LPREEVLPEKEKILDKLELSLIHSRG------DSSELRPDDTKAEEKE-------------PIETQQNGD---KEEDDEGKKEDKK-GKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDP----TIQQGAFGSSQMYSNNFGPNFRGPGPGGIVNYNQMPLGPYVTDI----------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GT72-1", "uniprot_id": "A0AC58GT72_DANRE", "id": "A0AC58GT72-1", "name": "", "aln": "MQSKLLTFVCFIQLIFELKSVIHYICLPFVLYSYQDSLRRTHSCKLLVFFSDDEEGELQRSVPLSPLERFFSEEDNVKQHKKKKTSKIMEGKEPKVKKKKKKEGLPSGLDDMSDRE-DHGHRSGSESSTYSALKKKKKKPREKKERK-MKQRKKEDDEDEDDDDDGNMKEPKSSSQLMQEWGLEDVQYAFSEDDYKTITNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFK----GTSATAVAAAVAAAVETVNVAPPICIRSIQQISPTGPIKKAKTKEGKGPGAKKKSKPGKETKKKGKPKKSK----SKAGPGGKRKKGSSSEEDFLDDFSDFDD----------------ISIHSASVRSDTSAAAKK---------------------KSSRKGRKKRKREDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEAKDDEEEEDE-VAGEEEDDHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCMCPPLKGKVQKILHWSWGDPPLPPEVPLGPDGEKVDNLAKTPLKGRPERQLFVKWAGLSYWHCSWVSELQLELYHTVMYRNYQRKNDMDEPPPYDYGSGEEELNNE-KRRSKDPQ-------YAAMEERFYRYGIKPEWLIIHRILNHSFDKDGDVQYLIKWRDLPYDQCSWEADDFDVPDYDSLKQAYWDHRNQVLGENHQP--LLFRKGKRPKEEMKRREP--------PPDTPVVDPTIKFEQQPWYIDDTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRAIIRENEFTFEDSAVKSGRKVFRMKKDTPIKFHVLLTSYELITIDQAILGSITWACLVVDEAHRLKNNQSKFFRILNGYKIYYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGNLLVKSSGKLTLLQKMLIKLKDGGHRVLIFSQMTKMLDLLEDFLEFEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDDVEAARTMGELKVLEMKSIVLP----LCVPIAEVLNLSSTGDNKEGEEVSVIHYDDNAISKLLDRSQDATEDTEIQNMNEYLSSFKVAQYVVREEDGEEEVQREIIKQE-ENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYND-------ASQEDQEWQDDLSDNQSEYSVGSEDEDEDFEERPEG--GRRHSRRQLKSDRDKPLPPLLARVSGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKFSTPDRIPV--------------GLELKKLTESVSSDPNTPVPASPVPTQPSTPVPSDKTESVSGSQEDKEIAEPENTKPLDPEPVVPEPSPAPEKTNEGEETKNGSPEEKRLEESEKSDTPPVQSEPSANQAPPPTKQCEQPANQTPSDCGKGKETSPERGETKPSPPKTEDKEQKPAIPDDVKSEDPPENQVNGEKDVRDETDEGHRDDKSSIKTRFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYAILNEPFKTEMHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPSHPAMALNTRFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRVPPVSARLQMSERGILSRLTSRGNEPPPQQPFPQGSFGCSQMYNSSFAGGFRGPGGTAMVNYSQMPLGPYVSVSSNGPPAPTSLLEKKSSDVLRDVVTPDLKSGKPSDVICIED", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O97159-1", "uniprot_id": "CHDM_DROME", "id": "O97159-1", "name": "ATP-dependent chromatin remodeler Mi-2", "aln": "MASEEENDDNFQEEEEAQEDNAP-----------------------AAELSNDSDAPLKPN---NDEDDDYDPED--SRRKKKGKKRKTRKGEEKGRKKKKR--------KKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEE-----------KQAAKEKESASSGMP---SVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDE-------------HQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQ---------RSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIR-GSKVSRLR-TTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKE-----------------------------------------DDKE----EAIHYDDKAVAELLDRTNRGIEEKE-SWANEYLSSFKVASYATKEEE--EEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGS-DEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTE--PKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVP-GREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASN--AAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPGQLSNNSGV-------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . . : . . :*::.:. *: : : * . *** .: . * ::***. . .: * * . .* *.. .*: :* ::: : .*.:. .. : * :: :.: :*: :**:: :::*.**** :.:**:: *:****. .*:: ::.******. .**. *::.:. :*. * :* * . : .:* :* : .** : :. : * : ***:.**.**: . *: *. . . * ::: **. : *...: :*.:. :*:. * :*****************************:***::.*********** :* * :**:: * ****************:***:** .****** **:*:* **** ****.**.::*: * * : . .. *: *:** .:*****.** *:**:::*.:* *.:*** **:*** :: . .: : . : :: ** :*****: *:****::::*::** :.*. **:**::****:.:** : *: . : * . * .* : :**:: : . * **:.* .* . *::.** ::: ** *****:**:****:**.** *************:**:.**********.:**:**:.****::*******:****** :** ***:**::*****::**:.*:: * ** *:: . **:*********::* * **** ** **********.*******:**.*.* ************************: ::**:*:.* ****:***:*:*:**::**********:**:****:*:*:******* ****:******:*:******.**.. **:***************** ** **. ..* *: . *.*::*** **.*** :*: .**************:****** * ************ ***************** ******************************************** :********** *****:******************:*.* ..::********:****:***: *:*: ..***** *:::****.: . ::.* . **********.*..:**: ** : *:***: ** ** ** *********:***:.*.******:******.* ::::*.:***: *: :**** ** *** . :: : ..*:::*:*: *:*********.**************:*******:**********:***********::*:****************.***************************:*********:** :* *: : . * :.....*. ..:*. ... ..: . .:*: . :. : . . . :. . .: : : *: . : : * : . : . . ** : . :* .:. . * :***************** ***:***. *: *:*******************.******** *: *:***** :: ***:**:*****************************::***.****:**:*:*******************************************:**:***: *:*:***: *******.*****: ..:. . : : : . : : ", "identical_positions": 979, "similar_positions": 438, "identity": "45.6%" }, { "cls_id": "homologset.agr.HGNC:16817", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7ESE9-1", "uniprot_id": "F7ESE9_RAT", "id": "F7ESE9-1", "name": "", "aln": "----------MGTPGVSAGALFLSSASAPPRKRAAGEAGEAGVAKSKQRVLDEEEYIEVPGLQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKISREPPPP---YVTPATFETPE--VHPGSGVLGSKPRPQGRDPEDAGEAGEEE--EKEPLPSLDVFLSRYTSEDNASFQEIMEVAKEKSHARHAWLYQAEEEFEKRQKDNLELPSAEHQAIES-SQAGVETWKYKAKNSLMYYPEGVPDEE----QLFKKPRQIVHKNTRFLRDPFSQALSRSQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGMNESPLMTWGEVENTPLRVEGSESPYVDRTPGPTFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLAS--LTPKGLSP-AMSPALQRLVSRTASKYTDRALRASYTPSPAR--------STHLKTPAGGPQTPTSTPAPGSATRTPLTQDPASITDNLLQLP-ARRKASDFF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O70279-1", "uniprot_id": "ESS2_MOUSE", "id": "O70279-1", "name": "Splicing factor ESS-2 homolog", "aln": "----------MGTPGTSAGALFLSSASAPSRKRAAGEAGEAGVARSRQRVLDEEEYIEG--LQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKISREPPPP---YVTPATFETPE--VHPGSAVLGNKPRPQGRDLDD-GEAGEEE--EKEPLPSLDVFLSQYTSEDNASFQEIMEVAKEKSHARHAWLYQAEEEFEKRQKDNLELPSAEHQAIES-SQAGVETWKYKAKNSLMYYPEGVPDEE----QLFKKPRQIVHKNTRFLRDPFSQALSRSQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPLMTWGEVENTPLRVEGSESPYVDRTPGPTFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLAS--LTPKGLSP-AMSPALQRLVSRTASKYTDRALRASYTPSPAR--------SSHLKTPAGGPQTPTSTPAPGSATRTPLTQDPASITDNLLQLP-ARRKASDFF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96DF8-1", "uniprot_id": "ESS2_HUMAN", "id": "Q96DF8-1", "name": "Splicing factor ESS-2 homolog", "aln": "----------METPGASASSLLLPAASRPPRKR---EAGEAGAATSKQRVLDEEEYIEG--LQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKMSREPPPP---YVTPATFETPE--VHAGTGVVGNKPRPRGRGLED-GEAGEEE--EKEPLPSLDVFLSRYTSEDNASFQEIMEVAKERSRARHAWLYQAEEEFEKRQKDNLELPSAEHQAIES-SQASVETWKYKAKNSLMYYPEGVPDEE----QLFKKPRQVVHKNTRFLRDPFSQALSRCQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPMMTWGEVENTPLRVEGSETPYVDRTPGPAFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLAS--LTPKGLSP-AMSPALQRLVSRTASKYTDRALRASYTPSPAR--------STHLKTPASGLQTPTSTPAPGSATRTPLTQDPASITDNLLQLP-ARRKASDFF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QAX0-1", "uniprot_id": "F1QAX0_DANRE", "id": "F1QAX0-1", "name": "", "aln": "----------MAESREKAVCLRSDVTTVAVRNP----VEES--KKPKRKILDEEQYIES--LEKIIQRDFFPDVSKLQAQKDYLEAEENGDLERMREIAIKYGSAMAKYTPRTYVP---HVTPSTFETPD--GRSAS---PSSSQSKSRAAREDGKDGEKA--SEKDLPSLDRFLSKNTSEDNASFEQIMELAEDKDKLRHAWLYEAENEYKERHEQNLALPSSEKQALEC-TKAGLETWQYKAKNSLMYYPEGEKDD-----TLFKKPREVLYKNTRFEDDPFCKALNKSQIQQAAALNAQFKQGKVGPDGKELLPHESPKVNGYGYEGAPSPAPGVAESPLMTWGEIESTPFRLEGSDTPLVERSHGPSFKIPEPGRRERLGLKMANEAAAKNRAKKQEALRKVTENLAS--LTPKGLSPAALSPALQRLVNRSSSKYTDKALRASYTPSPAHR-------SLGAKTPSGGLTTLTPTPTK---TRTPASQDPASITDNLLQLP-KRRKAQDYF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O44424-1", "uniprot_id": "ESS2_DROME", "id": "O44424-1", "name": "Splicing factor ESS-2 homolog", "aln": "MSATTRTPATPGTPGTPGSLAMEVARVQNSALAEFKKPTAMVRHKNKPKILTEEKYIEE--MSKIIQRDFFPDLERLRAQNDYLDAESRRDFVQMAEIRERYSLGRISGTGRSTSRRNNAMSPATFETPVSQAKCSNTPLPNSRATDTPFSTDGSEKSDAEGRDTTAKLSLDAFLQKYTSEDNQSFQEIIETAEAKLRQKYAVLYNHEKLSAEQLQRALMLPSIETQFEEPDPLRKIETWNYTNMNSIMYVPDGVEYTEEERVQLAERKQSIQHNATRLPDEAKHREMDTKKLNDEVPQNGAGG------------ATATPKVRGFDLLRSPSPRPGEAFSPIMTWGEIDGTPFRLDGGDTPLRP-TQGPSFRINENSRRENIAIALAERVSERMRNQKQMALDTARRNIGSPLIRTNMERLASMSPAAQLLATGKLGIRGTPRLRHTPSPMSGRKRKVTPGVVRSTNTPILGEPKPKQQAKISTPAKNVTIDTGSTLTDDLLKIPTKRRTAADFF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : ::* **:*** :..:********:.:*:**::**:**.. *: :* :* ::. . . : .. ::*:***** : .. .. . : .: .: . *** **.: ***** **::*:* *: : : ::* **: *: :: : * *** * * * . :***:*. **:** *:* * :: :.: :: **: :. : :. :::: .. *. . :*:* *:. :*** ** **:*****::.**:*::*.::* : **:*:* * .***.:.: :*:..: : * :** ** . .*:.* : .: ::*** * *.. . . ** : :* ..: :** * . . . ::. : :::**:**::* **.* *:*", "identical_positions": 127, "similar_positions": 151, "identity": "24.61%" }, { "cls_id": "homologset.agr.HGNC:16818", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZEH4-1", "uniprot_id": "D3ZEH4_RAT", "id": "D3ZEH4-1", "name": "Pseudouridine-5'-phosphatase", "aln": "--------------MAEAVPVPQLRPVTHLIFDLDGLLLNTEDLYTDVFQAICSRYGK-KYNWDVKSLVMGKKAPETTQIIVDFLKLPISKEQLLEESQERLQKVLHTAALMPGAEELIHHLRKNRLPFALATSSATLSFQTKTSRYKGFFSLFHHIVLGD-DPEVI--NSKPAPDIFLT----CAKRFSPPPNPEDCLVFEDSPNGVEAAVACGMQVVMVPHENLSSDLTTKATLVLSSLHEFK-PELFGLPAFDE--------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D5U5-1", "uniprot_id": "HDHD1_MOUSE", "id": "Q9D5U5-1", "name": "Pseudouridine-5'-phosphatase", "aln": "--------------MAAAVPVPQFRPVTPLIFDLDGLILNTEDLYTDVFEEICNRYGK-KYNWDVKSLVMGKKALETAQTIVEFLNLPISKEELLKESQEKLQMVLHTAGFMPGAEELIHHLKKHRLPFALATSSETVTFQTKTSRHTGFFGLFHHIVLGD-DPEVK--NGKPGMDIFLT----CAKRFSPPPDPKDCLVFEDSPNGVEAAIHCGMQVVMVPHENLSADLTRKATLVLSSLHDFK-PELFGLPAFTE--------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q08623-1", "uniprot_id": "HDHD1_HUMAN", "id": "Q08623-1", "name": "Pseudouridine-5'-phosphatase", "aln": "--------------MAAPP-----QPVTHLIFDMDGLLLDTERLYSVVFQEICNRYDK-KYSWDVKSLVMGKKALEAAQIIIDVLQLPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHGIPFALATSSGSASFDMKTSRHKEFFSLFSHIVLGD-DPEVQ--HGKPDPDIFLA----CAKRFSPPPAMEKCLVFEDAPNGVEAALAAGMQVVMVPDGNLSRDLTTKATLVLNSLQDFQ-PELFGLPSYE---------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N669-1", "uniprot_id": "A0A8M1N669_DANRE", "id": "A0A8M1N669-1", "name": "Pseudouridine-5'-phosphatase", "aln": "---------------------MSYKPVTHVLFDMDGLLLDTERLYTVSFQEVCDRFNK-QYTWEVKSSVMGKKALDAARIIRDKIGLPMTPEELLEETRKIQERLFPTTSLLPGVEKLVNHLHKHGIPIAVGTSSAGLTFEMKTSRHKEFFSLFSHIVLGD-DPDVK--NGKPLPDTFLV----CAKRFSPPANPKQCLVFEDAPNGVKAGLAAGMQVVMIPDDNLDRSLTQEATLLLRSMEDFR-PELFGLPAYA---------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q94529-1", "uniprot_id": "GS1_DROME", "id": "Q94529-1", "name": "Probable pseudouridine-5'-phosphatase", "aln": "--------------MANKV----LRKVTHCVFDMDGLLLDTERLYTVATEMILEPYGK-TYPFEIKEQVMGLQTEPLARFMVEHYELPMSWEEYARQQRANTEILMRNAQLMPGAERLLRHLHANKVPFCLATSSGADMVELKTAQHRELFSLFNHKVCGSSDKEVV--NGKPAPDIFLV----AAGRFGVPPKPSDCLVFEDSPNGVTAANSAGMQVVMVPDPRLSQEKTSHATQVLASLADFK-PEQFGLPAFTD--------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VQ04-1", "uniprot_id": "Q9VQ04_DROME", "id": "Q9VQ04-1", "name": "", "aln": "--------------MPTKK---CYCPVTHVIFDCDGTLIDSEGIYLKTVQDLLAKYGK-TYTKVDQTQHMGMPVGTFSQHIVKDLKLPLSPAEFQKEFEAAVDKSMGSVALLPGVRDLILHLHEYRIPFCIATSSFRKLFKVKAESFKDIFLAFHHVVCGD-DPALGPGRGKPYPDIYLL----AASRFNPPADPKKCLIFEDAPVGLIGGKAAGSQVIFIPTDNVSKQQKKGATMVLKSMADFK-PELFGLPPFDTCSKFEFG-------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q86ZR7-1", "uniprot_id": "YKD3A_YEAST", "id": "Q86ZR7-1", "name": "Probable pseudouridine-5'-phosphatase YKL033W-A", "aln": "--------------MTHPV------AVKACLFDMDGLLINTEDIYTETLNETLAEFGKGPLTWDVKIKLQGLPGPEAGKRVIEHYKLPITLDEYDERNVALQSLKWGTCEFLPGALNLLKYLKLKNIPIALCTSSNKTKFRGKTSHLEEGFDLFDTIVTGD-DPRIAKGRGKPFPDIWQLGLKELNEKFHTDIKPDECIVFEDGIPGVKSAKAFGAHVIWVPHPEAHAVLGDTEALLAGKGELLSSLEKLEMSKYGL--------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VQ01-1", "uniprot_id": "Q9VQ01_DROME", "id": "Q9VQ01-1", "name": "", "aln": "MCSACCKSCKAPPGCSLCPPMCCSPGISYCIFDLESAVFDTRHVYKRAVIELAASYNK-IIPEAVLIKSGPMETAEMAELICRKCDLPVSWESFRFQLNERTSDLIANPTLMPGVERLVTHLGRCCMGLGLITSCSESMYCTKIRDREDFFQNFSSVICAD-DADLK--APKPEPDVYLI----AMRRLG-DAGPDCTLVFDGTPKGVQAATDARLPVVMLAEKDLPCCWSELATLRLETLEEFD-PAEFNMPPYSCTEPPPKKPKASSHRSSQKSAGSQRGSAALKKAAADSEADEGEEEEGEGQEVA----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VQ02-1", "uniprot_id": "Q9VQ02_DROME", "id": "Q9VQ02-1", "name": "Pseudouridine-5'-phosphatase", "aln": "MCTFGCRTCKSQPDCEGCSPKCCSPCISYCIFDLESAVFDTRHVYRKALKELVRCYDK-RIPDILHVQSGPMTISEMSELFCRKLDIPMSWESFRYELNERTSHLIANPPFMDGIERLVPHLRNSCMELGLITSSNEANYCSKIRGREDFFENFSTVVCAD-DPELR--APKPEPDVYLI----AMSRLG-DAGPDCTLVFDGTPKGVQAASDARLPVIMLAEKDLPCCWSELAALRFEYLDDFE-PEMYNLPPF--TDPAPKR--RSSRRRTRYSQRLTVIRARAAEAAAAEEAEAEEEEPAEPPPPAALPSILNLRE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. :** :. ::::. :* :.* . . :*:: . . . . :: * *: :* : : : **. * * * : .. * : ** * : :: . ::*:. *: .. *: :. : : :. : ", "identical_positions": 20, "similar_positions": 53, "identity": "6.27%" }, { "cls_id": "homologset.agr.HGNC:1682", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q61735-1", "uniprot_id": "CD47_MOUSE", "id": "Q61735-1", "name": "Leukocyte surface antigen CD47", "aln": "MWPLAAALLLGSCCCGSAQLLFSNVNSIEFTSCNETVVIPCIVRNVEAQSTEEMFVKWKLNKSY--IFIYDGNKNSTTTDQNFTSAKISVSDLINGIASLKMDKRDAM--VGNYTCEVTELSREGKTVIELKNRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAIL-ITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNR------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P97829-1", "uniprot_id": "CD47_RAT", "id": "P97829-1", "name": "Leukocyte surface antigen CD47", "aln": "MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSY--IFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAV--VGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAIL-ITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q08722-1", "uniprot_id": "CD47_HUMAN", "id": "Q08722-1", "name": "Leukocyte surface antigen CD47", "aln": "MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRD--IYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAIL-VIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1MA83-1", "uniprot_id": "F1MA83_RAT", "id": "F1MA83-1", "name": "Leukocyte surface antigen CD47", "aln": "MWPLLVALLLGSFHCGLAQLLFKNISSVKIDHCKNIVLIPCYVSNLEAENINELFLKWKFGRNSDIIFVFDGYANKSAAFYKFSSAHIFPSEFLKGNASLNVAKEEVK--NGKYTCEVTELSREGQQTVDLQYTDGSLFTLKEHISIIILPFLTLILFWAQFGILIQKYKSNPVNRKTIILFATGLLITIVVITGASLLIPGGFAKRKGYGFAFLTTPSVIPVFLQYHKFKPAIGRTLHTVIMLTIIQAVGTVLTVAGLYHSSLDCVPRYGSILILGLAIVALGELFGLIYMKCFDP-LIEFQ-----------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** .****** ** ****:.: .*::: *:: *:*** * *:**:. *:::***: *: :** *.:: .*:**:* *::::* ***.: . :. *:********:***: ::*: * *: :*:* *:*:*:::::***.:*** **:*. :.: * *:.:** :*::*:.** *::** . ::. *:.::. .: * ::*:* * .*:* * ..: :* : *.:. :*::.*: . * * :*.:** **.*:**.:*:**:*** . . :* ", "identical_positions": 112, "similar_positions": 110, "identity": "34.36%" }, { "cls_id": "homologset.agr.HGNC:16820", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5ND28-1", "uniprot_id": "SREC_MOUSE", "id": "Q5ND28-1", "name": "Scavenger receptor class F member 1", "aln": "MLAAMGLELVFSLLLLWTQGTQGSTLDPAGQHVCKGSSP-SELQCCPGWRQKDQECTIPICEGPDACRKEEVCVKPGLCRCKPGFFGAQCSSRCPGQYWGHDCRETCPCHPRGQCEPATGDCQCQPNYWGRLCEFPCTCGPHGQCDPKTGLCHCDPGWWSPTCRRPCQCN-PASRCDQATGTCVCPPGWWGRRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRG--QCSVTSGHCSCPPGFHGIRCELPCNPGHYGAQCKESCGHCELNATCSPVTGNCESCKPGWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDPGWLGHRCENPCPLGTFGKGCSSTCPACAQGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLGRHGKN-ALIVGILVPLLLLLMGIVCCAYCCSGTRLDPKDRPERNGAAFFRMKQQVWGALTNLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFVPPREEMVPMAQEESPEASLPGGSFPPP-----EDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSS-GDLSSPIRKPK----------RLSRGAQPRPEGQEAEESTGPEQVNTEEDAPTATSSGDP-------ATSHGQLPPGSQ----MVAECAETTDGGIQESSGSVATIYMLAGTP-------QKPEGPVWSVFRRLGNYQ--KDQMDPKVKSAIPKPLRRSLGRNQAS--------------------------------------AGSAPGAVLS---------QAMESTAVRPEETPRGLGDGIESSGTVQEPDAGGSSLEQDSQKQAEEKEQEEPLYENVVPMSVPPQH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZRK9-1", "uniprot_id": "A0A8I5ZRK9_RAT", "id": "A0A8I5ZRK9-1", "name": "", "aln": "MLTAMGLGLVFSLLLFWTREIQGSTLDPAGQHVCIGSSP-SELQCCSGWRQKDQECTIPICEGPDACKKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRETCPCHPRGQCEPATGVCQCQPNYWGKLCEFPCTCGPHGKCDPKTGLCHCDPGWWSPTCRRPCQCN-PLARCDQVTGACICPTGWWGHRCSFSCNCHTSPCLQDSGRCTCLQGWWGPECSRRCQCVRG--QCSVTSGHCSCPPGFQGALCELPCKPGRYGAQCKESCGHCEPNATCSPVTGNCESCKPGWNGTQCKQPCPPGTFGERCTGKCPRCRLEEPCQVETGHCQRCDPGWLGHRCEKPCPLGTFGKGCSSTCPACVQGTCNAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSMPCQCPEGLCHPESGACQLGPHGKN-ALIVGILVPLLLLLMGIICCVYCCSASRLDPKDRPERNGAAFFRMKQQVWGALTSLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFMPPREETVPMTQEESPAASLPGGPFPPP-----EDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSS-GDLSSPIRKPK----------RLSRGAQPRPEGQEAEESTGPEQENPEEDVPTATSSGDA-------ATSHGQLPPGSR----TVTECVETTDGGIQESSGSVATIYMLAGTP-------QKPEGPVWSVFRRLGNYQ--KDQAAPKVKSAIPKPLRRSLGRNQASSGLSQ--------------------------------SSGSAPGAVLS---------GAMESTAVKPEEASRGLGDGIESLGTVQEPVVGSSSPEQGSQKQAEEQEQEEPLYENVVPM---LQH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14162-1", "uniprot_id": "SREC_HUMAN", "id": "Q14162-1", "name": "Scavenger receptor class F member 1", "aln": "----MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRG--RCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPP-----EDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSS-GELSSPLRKPK----------RLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDS-------ATGHRRPPLGGR----TVAEHVEAIEGSVQESSGPVTTIYMLAGKP-------RGSEGPVRSVFRHFGSFQ--KGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSV---------------------------GQSPNSAPKAGLP---------GATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FBT2-1", "uniprot_id": "E7FBT2_DANRE", "id": "E7FBT2-1", "name": "", "aln": "----MDTFLTSFGLMLMCVQYSAQRLSLTGKNVCLSVRD-SSAICCSGWGQSGDECTVPLCEGERACLQDEVCVYPGLCRCKAGFYGYQCKAPCPPEFWGPDCREFCPCHPHGLCDPATGVCSCLPNRWGSLCQNSCKCGRHGKCDPVYGNCTCEEGWWTSTCSKACQCHLATSTCDQATGRCICNEGYWGQKCSLPCNCYVSPCQQRTGTCQCLHGWWGPSCDRRCICNLNNADCDVQTGGCLCYPGYKEPFCNEPCDSGKYGRGCKNSCGRCEGGRPCSKLDGLCDACEPGWNGTRCDQRCPAGYYGHRCQEICPHCRNMDPCDPETGACLQCNPGWTGPRCDKPCTDGRYGDGCRFLCKTCNHGHCDHVTGRCICLPGFQGESCNSTCPFNLYGFNCSSTCDCGSQACHPATGACP---NSSRAGLLAGLLIPLCILILALLFCCCCCGRPVEGKERVTVGDGSPAVRMKHHVYTVLANMGSAMPCITLWSSGLPRVTVSHHDPELTFNHSFIEQPSSGWVID-SFETD-----EDGEAVYCEPPREDVLTEAGGELQELNSKCNFFPDPSTFSSEDMSQAFGIPRTSSIAKSKRPSVSFAEGTKFSPKERRSSTQDLQGTARKPKPWGVLMISALQGGQGNQNNETETEKEEKNDEENISEEQRASSETLQNDSERYSSGPQRTHLTVPGGRRRTLSNPKKNIQSSDGGQDADSEKLTTVYVTVGKTSKMVKQEPPSEGPVQAMLRRLGSLQRQKEEVAKGKAQSIVKPPRRKLGARASAWEQASGSGQSEVVMRKPSRKKHSSLSSPCIVGAIDSPQENSAPKRPLSSILKSVPESDPFQSLEVEPNSEETGIQT-EHTYETVALPDTVSTSSEIIINDTVMDQAENEPNYENVYLKH-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. * *:: ... *. *::** . :. **.** *..:***:*:*** ** ::**** *******.**:* :*.: ** ::** **** *****:* *:**** *.* .: ** *: .* ** **:*** * * *: ***:.** :.***: . : *:*.** *:* *:**::**: ***: *** * :* * * *****.*.::* * . *.. :* * * **:: *: ** .* :* * .***:*: . .** * *::*:******:*.* * .* :*. * **:** :.*: :** * :*:*** * **:.**. * :*..* * :* :* *: *** *:* .*: * ***::** .::* *** .*:* . *** :*:* . .*:.* *:** :*::.: * ** . . : . :*:. *** :*: .*:.:**::** :* . ** *********:.******* **:**. * **.:* * .* **:* :. : . . ** * ** * .* ******:*::*************:*:. *** :*... **** : .:* * * **... *: . : .: : .*. * * * : : :: :*. : .* ::*:*: .*.. .**** :::*::*. * * : :* ** *: *. . .: .*** *. . . *.*:. *: .: . * * * :. . :: ::** **** ", "identical_positions": 319, "similar_positions": 219, "identity": "35.13%" }, { "cls_id": "homologset.agr.HGNC:16821", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K0Z9-1", "uniprot_id": "A0A0G2K0Z9_RAT", "id": "A0A0G2K0Z9-1", "name": "", "aln": "------------------MGKAKRTGARRQVHKAPAGAFG--------GPGKTNPNPFEVKVNRQKFQ---ILGRKTRHDVGLPGVSRARAIKKRTQTLLKEYKERNKSNVFTDKRFGEYNSNISPEEKMMKR----FALEQQRYHEKKNIYNLNEDEE-LTHYGQSLADIEKHNDIVDSDSDTEDRGALSAELTASHFGGG--VHKNSSQKEGEDGDKPKTRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQILLSRKSKKSENKEKKEKPQPDAYDMMVRELGFEMKAQPSNRMKTEEELAKEEQEKLRKLEAERLRRMLG---KDEHENKKKPKHTSADDLNDGFILDKDDRRLLSYKDGKMNIED-AQEEQSKGADGQENDQKEEEDESEEEGEDGESCEDPDESDGPDSHSDLESSAETEEEDETPKKEQRQTPGGKSPKEAQKAQKAAAAELPYVFAAPESFEELKFLLSGRSMEEQLLVVERIQKCNHPSLAVGNKAKLEKLFGFLLQYIGDLATDSTPD-----LKTIDKLVVHLYNLCQMFPESASDAIRFVLRDAMHEMEEMIETKGRAAFPGLDVLIYLKITGLLFPTSDFWHPVVTPALICMSQMLTKCPVTSLRDVVKGLFVCCLFLEYVSLSRRFVPELLNFLLGILYIATPNKKSQGSTLVHPFRALGKNSELLVVSDKADVTTWQRGSLPLHWANRQSTLTATEANHTRLSCVASCLSLLKHCVLMYSALPSFHAIVTPHQALLAEHLAR-SLPQELQELSRSILSEVESQKQHCPPLICEKSKPVPLKQFTPRLVKVLEFGRK-QGSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEVD----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R3N1-1", "uniprot_id": "NOP14_MOUSE", "id": "Q8R3N1-1", "name": "Nucleolar protein 14", "aln": "------------------MGKAKRTGARRQVHKAPAGASG--------GPAKTNPNPFEVKVNRQKFQ---ILGRKTRHDVGLPGVSRARAIRKRTQTLLKEYKERNKSNVFADKRFGEYNSNISPEEKMMKR----FALEQQRYHEKKNIYNLNEDEE-LTHYGQSLADIEKHNDIVDSDSDTEDRGALSAELTASHFGGG--VHKNSSQKEGEDGDKPKTRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQILMSRKPKKSEDKEKKEKPQPDEYDMMVRELGFEMKAQPSNRMKTEEELAKEEQERLKKLEAERLRRMLG---KDEHENKKKPKHTSADDLNDGFILDKDDRRLLSYKDGKMNIED-VQEEQSKEADGQENDQKEGEDDSEEEDE---SHEDSEESEDPDSHSDLESNIESEEENETPKKEQRQTPGGKLPKDDQKAQKAVAAELPYVFAAPESFEELKFLLSGRSMEEQLLVVERIQKCNHPSLAVGNKAKLEKLFGFLLQYIGDLATDSTPD-----LKTIDKLVVHLYSLCQMFPESASDSIRFVLRDAMHEMEEMIETKGRAAFPGLDVLIYLKITGLLFPTSDFWHPVVTPALLCMSQMLTKCPVMSLQDVIKGLFVCCLFLEYVSLSRRFIPELFNFLLGILYIATPNTKSQGSTLVHPFRALGKNSELLVVSDKADVTTWQRGSLPLHWANRLSTLTATEANHTRLSCVASCLSLMKHCVLMYQALPSFHAIFRPHQALLSKHLADCSLPQELQELAQSILSAMEGQKQHCRPLVCEKSKPVPLKQFTPRLVKVLEFGRK-QGSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGEWKALKRKKFKK-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P78316-1", "uniprot_id": "NOP14_HUMAN", "id": "P78316-1", "name": "Nucleolar protein 14", "aln": "------------------MAKAKKVGARRKASGAPAGARG--------GPAKANSNPFEVKVNRQKFQ---ILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKR----FALEQQRHHEKKSIYNLNEDEE-LTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLG---KDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGG---------EDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEYVGDLATDDPPD-----LTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAALPGLDVLIYLKITGLLFPTSDFWHPVVTPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLEYVALSQRFIPELINFLLGILYIATPNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQQSSLSLRWASRLRAPTSTEANHIRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLTDHLADCSHPQELQELCQSTLTEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRK-QGSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGEWKALKRKKFKK-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VEJ2-1", "uniprot_id": "NOP14_DROME", "id": "Q9VEJ2-1", "name": "Nucleolar protein 14 homolog", "aln": "-----------------MVAKGKKASADAVYAKKTTRSANPFDN--STAQSSKRGNPFDVHVNKEKFK---ILGRICKHDRGMPGVSRAKALQKRAQTLGQQFAVKHKTNRFKDNRIGKHLSGDQLTESVMNARYLAEKMSQVRSNQKAEKFNLNDDEL-LTHRGQTLEEIEQYRDERSDDEELDDEALDADFTAAAHFGGE--------------GDSAQDRQAAIDEMIVEQKRRKNEIAKEKDEVYDLTEKLDANYKLLLPLVAKVTKD----EQDAKPPPDAYDKLLKEMIFEPRGSVADKLINPDELAKQEAARLEKLENERLRRMRADGEEDEEASVAKPKHRSADDLDDGYFLAGEDDEGDDTLAYDLDGNLGTHLNGKKEAVLKGDENEDDDDKEGEEE------EEEDSDEESDSEVDNLSDLK-ESESESEPEEAPKASKKKAKKSADTIPASLDTSIPFTIKMPKTYEDFTELLSKHATAQKAIIIERIIKCNHPKLEGVNRENVVKLYSFLLQYLKDLFEDASEQDIREHFQLLSKLMPYLYELTQLNPERMSNTLLEVIKEKYEEFR-----KNHKMYPSLDTLVYFKLVANLYSTSDFRHPVVTPCFIFIQHVLSRSRVRTRQEISMGLFLVTVVLEFVSQSKRLVPAVFNFLQGIVHMSIPKRDVEQLEITPPFERDGPLSKLLALPANTESTKLEPQQLQP-----TDLVTQTITPDFKVRALDTSLLLIKEALQLVEEHVGACYLAQPFLALLSRLPLESYPEHVHQHHKDATELAEKLAAQKMKPLAPAEKKPKALRLLEPRFEAVYDDKRR-PKMSKAKEERAKLLHKIKREKKGAIREIRRDTSFVQMLRLKQTLQSDKERHEKVKRIYQEASVQQGELNELSRAKKKKKF---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q99207-1", "uniprot_id": "NOP14_YEAST", "id": "Q99207-1", "name": "Nucleolar complex protein 14", "aln": "MAGSQLKNLKAALKARGLTGQTNVKSKNKKNSKRQAKEYDREEKKKAIAEIREEFNPFEIKAARNKRRDGLPSKTADRIAVGKPGISKQIGEEQRKRAFEARKMMKNKRGGVIDKRFGERDKLLTEEEKMLER---FTRERQSQSKRNANLFNLEDDEDDGDMFGDGLTHLGQSLSLEDELANDEEDFLASKRFNEDDAELQ-------------QPQRKKTKAEVMKEVIAKSKFYKQERQKAQGIMEDQIDNLDDNFEDVMSELMMTQPKKNPMEPKTDLD-KEYDIKVKELQLDKRAAPSDRTKTEEEKNAEAEEKKRELEQQRLDRMNG------MIELEEGEERGVEDLDDGFWENEEDYE-----------------------------------------------DDNDGIADSDDDIKFEDQGRDEGFSQILKKKN------------------------ISISCPRTHDALLDQVKKLDLDDHPKIVKNIIKAYQPKLAEGNKEKLGKFTAVLLRHIIFLSNQNYLKN----VQSFKRTQNALISILKSLSEKYNRELSEECRDYINEMQARYKKNHFDALSNGD-LVFFSIIGILFSTSDQYHLVITPALILMSQFLEQIKFNSLKRIAFGAVLVRIVSQYQRISKRYIPEVVYFFQKILLTFIVEKENQ--EKPLDFENIRLDSYELGLPLDVDFTKKRSTIIPLHTLSTMDTEAHPVDQCVSV-LLNVMESLDATISTVWKSLPAFNEIILPIQQLLSAYTSKYSDFEKPRNILNKVEKLTKFT--EHIPLALQNHKPVSIPTHAPKYEENFNPDKKSYDPDRTRSEINKMKAQLKKERKFTMKEIRKDAKFEARQRIEEKNKESSDYHAKMAHIVNTINTEEGAEKNKYERERKLRGGKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: : . : . . . ***:::. ::* : : * **:*: . .:* ::: . :.* . . *:*:*: . *.::: * : :.: . :**::** *: * .: : . .. : :: : . : : : :.*:*.:.* *.* : : ::** ::: : : . : . . . ** ::*: :: :. ::: . * : : .:** :** ** . . : :. ..:**:**: :* . :: : .*.. . .. . * .: :: : *.:.: : : :: :::.* *. :*.* *: :: *: ..**.:: * : . . :.: * : : .* . : :: .*:. : .. * *:::.: . *:.*** * *:**.:: :.:.* : . : : : * .: :. :: *:* :* :. *: *: : : *. * * :. : :. . : : . : : * : . : * **: . :. : ** : ** .: *: : :: .: ..* :: : *:* * :::***:* .* ::.: : . : : *: :: : .:: ", "identical_positions": 97, "similar_positions": 257, "identity": "10.61%" }, { "cls_id": "homologset.agr.HGNC:16822", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZIG8-1", "uniprot_id": "D3ZIG8_RAT", "id": "D3ZIG8-1", "name": "", "aln": "--------------------------MSPADAKRGAKRRKNKRGGGGGSGGG---SSGGKAGSAAALRGPQAP---GPG-AAGLLGG-AAAHGPLGAGAGG---AAGGYFETP-FSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGVKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHSGLDQPG--QDFLLHSSLGG---SQPETSGAGRLALGTQTMTSSGLGT--TPSDACSCEACSERRDISAETDREPQQLQNYWSEVRYMVRC---IYRQAGTPLAEDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCNEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQ-------------------------MTMKTKQRMLTEDWEIFKQRRLIEEQLTN--KKVVTGENNFTDTRRHMLSSRLSMPDCPNCN-----YRRRCACDDCSLS----------HILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASS-------------------GSGSS-----------------------------------------------------------------------------------------------------------------------------------------SPITIQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADD------EEADAESSGEPPGAPKQEEAIGNGNPRTEESKVNTPPPSYPAQQAEQTPNTCECHVCKQ---------EASGLPASAMTAGALPPG-HQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHS-----------KALPPAPVQSHTN-KPQAFNASLQDHIYPSCFGNTPDWN--------------------SSKFISLWESEMMNDKNWNPG-----------TFLPDTISGSDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKN----------------------------AAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHG------------LNKEDHRHSAPAAPRNSPTGLAPLPALSPSALS-----------PASTPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCEN------------------------------GVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGP-----------------PAAPTSRNYAEMREKLRLRLTKRKEEQ-PKKMEQISERE---------------------------------------GVVDHRRVEDLLQFINSSEAKP-VSSSRAAKRARHKQRKLEEKARLEAEARAR-EHLHHQEEQK-----------------QREEEEEEEEEDEEQRFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATEPISNSENIHNGSLEQTEEPETSSHSPS----RHMNHSEPRPGPG-----------------ANGDATDPVDPRD-SKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTS---KASSEPARKPTEP------------------------------------PKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNN----------------------------------------------------KKQLSHIKEEKLSTVTPEPPSPSQH-------------------------LQNGRLILASSPQPKGKNKKNKKKKGDRTSSSIVENTG-TELESKEGGHCNIPRILGH---------------LWMMFFCLKTSTWTMWIWMRPSGRWSISKGFAWTLLDRTDKDCPSTGPTLA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CGI1-1", "uniprot_id": "F193A_MOUSE", "id": "Q8CGI1-1", "name": "Protein FAM193A", "aln": "--------------------------MSPADAKRGAKRRKNKRGGGGGSGGG---GSGGKAGSAAALRGPQAP---GPG-AAGLLGG-AAAHGPLGAGAGG---AAGGYFETP-FSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGVKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHSGLDQPG--QDFLLHSSLGG---SQPETSGAGRLALGTQTMTSSGLGT--TPSDACSCEACSERRDISAETEREPQQLQNYWSEVRYMVRC---IYRQAGTPLAEDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQ-------------------------MTMKTKQRMLTEDWEIFKQRRLIEEQLTN--KKVVTGENNFTDTRRHMLSSRLSMPDCPNCN-----YRRRCACDDCSLS----------HILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASS-------------------GSGSS-----------------------------------------------------------------------------------------------------------------------------------------SPITIQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADD------EDADGESSGEPPGAPKQEEAIGNGNPKTEESNVNTPPPSYPAQQAEQTPNTCECHVCKQ---------EASGLPASAMTAGALPPG-HQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHS-----------KALPPAPVQSHTN-KPQAFNASLQDHIYPSCFGNTPDWN--------------------SSKFISLWESEMMNDKNWNPG-----------TFLPDTISGNDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKN----------------------------AAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHG------------LNKEDHRHSAPAAPRNSPTGLAPLPALSPSALS-----------PASTPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCEN------------------------------GVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGP-----------------PAAPTSRNYAEMREKLRLRLTKRKEEQ-PKKMEQISERE---------------------------------------GVVDHRRVEDLLQFINSSEAKP-VSSSRAAKRARHKQRKLEEKARLEAEARAR-EHLHHQEEQK-----------------QREEEEDEEEEDEEQHFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATESISNSENIHNGSLEQTEEPETSSHSPS----RHMNHSEPRPGPG-----------------ANGDATDPVDPRDPSKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTS---KTSNEPARKPTEP------------------------------------PKTTEVQLKPRAQPELKPKVVDLALLTEQKREERKTNSNNNN----------------------------------------------------KKQLSHIKEEKLSTVTPEPPSPSQL-------------------------LQNGRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDIDLDSVDMDETEREV-----------------EYFKRFCLDSAR-------QNRQRLSIN----WSNFSLKKATFAAH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P78312-7", "uniprot_id": "F193A_HUMAN", "id": "P78312-7", "name": "Protein FAM193A", "aln": "--------------------------MSPADAKRGAKRRKNKRGGGGGSGGGNGGASSGKAGPAAALRGSQAAGLAAPGSAAGLVGGAAAANGPLGAGASAGGAAPGGYFETP-FSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGIKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHGGLDQPVS-QDFLLHSSLGG---SQPEAGSGGRLALGAQTLPS---------DTACSCEACSERREISAEADREPQQLQNYWSEVRYTVRC---IYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQ-------------------------MTMKTKQRMLTEDWELFKQRRFIEEQLTN--KKAVTGENNFTDTMRHMLSSRLSMPDCPNCN-----YRRRCACDDCSLS----------HILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASS-------------------GSGSS-----------------------------------------------------------------------------------------------------------------------------------------SPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADD------EEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQ---------EASGLTPSAMTAGALPPG-HQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHS-----------KALPPAPVQNHTN-KHQVFNASLQDHIYPSCFGNTPEWN--------------------SSKFISLWGSEVMNDKNWNPG-----------TFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKN----------------------------AAKKKCLYNFQDAFMEANKVVMA------TSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHG------------ISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAAL------SPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPP---ATDGSISAPPSVCSDPDCEGHRCEN------------------------------GVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGP-----------------PAAPTSRNYAEMREKLRLRLTKRKEEQ-PKKMDQISERE---------------------------------------SVVDHRRVEDLLQFINSSETKP-VSSTRAAKRARHKQRKLEEKARLEAEARAR-EHLHLQEEQR-----------------RREEEEDEEEE--EDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPS----RHMNHSEPRPGLG-----------------ADGDAADPVDTRD-SKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTS---KASSEPARRPTEP------------------------------------PKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNN----------------------------------------------------KKQLNHIKDEKSNPTPMEPTSPGEH-------------------------QQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDDVFLPKDIDLDSVDMDETEREV-----------------EYFKRFCLDSAR-------QTRQRLSIN----WSNFSLKKATFAAH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4ICL0-1", "uniprot_id": "A0A0R4ICL0_DANRE", "id": "A0A0R4ICL0-1", "name": "", "aln": "--------------------------MSPTDAKRGAKRRKNKRGGGAGKAGAPPTPSSSSAHGDPSNIPSLNG-------EVPVNGAPQFSEGPVNADFSG-------VLQTP-FTFGVNQRAP-YTTGDRCLLCRSERKDT--ISQDMGGSSQNGTSQSSKSSSSLQLPLYVCSDCKRTVEKDDRQPPLDQSLLNQDFLLHMPMGNGSLSQEPLGSGGRLAVGAPTLPAPDLSAPITTDTVCSCEACYERREITAESERESQQLQNHWSEVRYLVRC---IYRQTGTPLADDQDQPLDRDKESMKELVDRLCEKDPYQLYQRLEQQAREYVLEMKVRLLKHLSTGSKAPG-AVAQGPPQAHQFISLLLEEYNALCQAARTISSFLLTLENEHLQKFQVTWELHNKHLFENLVFSEPILHNSLPALVAQLRQGTTSHDSYSEDMYRALLERYHQLDQEMSAVALEWLECEKRIDDYVDEQLLFKVEGQNLTNQRTEPHKSLINRNMSLRTKQRMLKEDAEIFKHKRFFEEQFQPNSKKSLGGDSKFTDTVKQMLSSRLSIPDCPNCN-----YRRRCTCDDCSLS----------HILTCGIMDAPMAEDLHLK---LQGEPPRDYMSEVHPPSMSSGSS-------------------GSGSAP---------------------------------------------------------------------------------------------------------------------------------------GSPITIQQHPRLILPQDGTT----AYDDEVPPLSA----IYPLSGYEDPAVVASINGIHSQLSGGEESLTLKDKSSRGSSSSSSSSEGDE------EER--ESGGEPPG---QKEVLSGG-------KHDCPPPSYPHTQVDHIQHPCECHVCTQG----TVDGSTSGLSSTCLPSSRLHAGGHQFFSEKTAAHPALHLYPHIHGHLPLHNLSHLPRPLL-PTLYSTPPLTHN-----------KTLPPTPTSSHTGGKQQAFNPTLPEHVYQSCFSTAGDWNGSLPCP--------------SLKLENLWDTHMM--KNWNPS-----------VLLQEPLPG-DMLGPPLPDVPLLSSSLDPSVNPHLSPDGKEKKN----------------------------GAKKKCLFNYQDAFMEASEVVMA------TSSATSSVSSTATTVQSN---------------EVFHN------------LGKEDHRHPTPIAPRNSPTSVSSLPPLNPASHA------------SSPNTLPSIVP----------PGFMDEQQ-----------------ASGANSVCSDPECEGHRCEGN-----------------------------GGYEHQPYEGEESQDEDSSSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGP-----------------PAAPTSRNYAEMREKLRLRLTKRKEEQQPKKEELVLERD---------------------------------------GVEDHRKVEDLLQFINSADSKQQGSSSKAAKRARHKQKKMEEKARLEAEARELEEQQQLLKEQR-----------------RRQQEE-------EAALKQELLHLQEMQQLRASKKKKKESKVK-----ELLAKSENPSLVPTINSPQPLQQTAQSVLEKNLQNGKTQ----LLHSLIRLSPREH-----------------CLEPQSLIGGKNTSSQQPCPKTCKERPSECPALQNGTSFYPESAHTKVKPKQQANGSKTNGEATKRPAET------------------------------------SKAPE-PPKAGNVASPQTDTKAKQRTSEESVTDIKREERTSG----------------------------------------------------KKPQNGGKDER-NSPVIEPPASDSS-------------------------QQNGKVPSNESPQPKSKAKKNKKKKGDKMNNSIDDVFLPKDIDLDSVDMDETEREV-----------------EYFKRFCLDSAR-------QTRQRLSIN----WSNFSLKKATFAAH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VG05-1", "uniprot_id": "Q9VG05_DROME", "id": "Q9VG05-1", "name": "", "aln": "MADQVAHTKETDADEPLVNGELPMEEAPPSCCHVMSLSSMDVDVDADAEGDVDATASSSCVATASQLNPSPPPAGVQQAKPARSSSPPCQLLERLSFPDGNIINTLHTILALPPFDPYAPAPKAETVYKEVVSLMQWSQREDNAIELELSDKLLHECEHKGGDPNDETRSYLMAIENMRLFSEDPKNPLRDADGQLRAITLYFQNLAFIFVKHRKEEFFTFCSCKECLEYRETIMAIMMDQFKAAHMVVMLLDVLIKAYSPMLKNDAAYNKFEKLLECNKEIYWITSGYLYDKNAEYLDFIDDTAISDNMILVLFSAILMANNPMLLLQILAYNVECIVKAFSEGMIEIAQNIQENEKISAERMLTYILDGYSDLNCISQKISLSLFAFENDFLRKFRLSWVLLCQRLFQQHVFTP-LGDTMLACILSLKEVAPSAQTTALIKRYMLFDEHMHSIERRWTDIWIELNKFNLSPTEHERRMGLLDVYN------------IFDKVVLDATSFSLPDISDDEFIDFQRIVDRQLAWK-NIMAFTKLKWPDGFYDPPNKLVHEDLCKKCNSLLEHHNENCKCITCSIAGTPLRPRQAGHCAKCTTLGIVEKDPKLMKSKILSTCTSDEAKHNAAIAATTSSSTSTAQQQRRTSDLPEDESPTGSGSSGSVFRRQAETSDTLRTTYHIAWAVFQHLATRKRYRHETIEPQFICGENCRVSACQLARKILSNQLSPLLTKYLLRCFQPLSFTREELRSTIPSLMFFNRKLAPSPAELQELRNQHYVYKTYWTFVLSIYANFFVKFNSSSTDFGHLELIKGDLRLRLNSVVGDKEDNRFEQFLAQVIGYSPFKVTDDFTLGDANIEKLQFGVDQLMMLHDSQIIKRTKPDSTTGLSGAKSKLGESNVPQSGGKNGEAGGNKKSKEKMRKCCSDYADIGEPCKENHSKKRVKKECNHARFNETRDRLRKKLSQIVNERKTKSTEETTPSKTKCSKPEPVAVPAPAAIPPKRPPSPFN-PPKLPAVLAVAALDRICREEHEDDSLLRLDSLCKSLQRHTDATDASAAAAALAAFKHGSGFPADYSKEDMMQDFAEFLGTYTYTREQDQQRWINETLNFIEGKSQQPHTANPKKAAKKAKQKMRKEEEKRIKELEDLRCQFLDIYFKEFIDKYEMKTLTAAGGRKKEKKRIGELETNIKNLQRAKAKVETVILELIATVKQTNSEFKFSYLPTKQQQLAKMAQLEEILNGGPTTATAEPVRQEPPQQSAPQYPEFSSNASFYHPPGLGQQNTPVCFAPPQQSQHPPQLSRDVIAAMAASSITADPSKRIVTIRRVQLPHPGAEQQVTVVAKGSAPHEDKLLYTFVNGHMVASGPIQPEEMAPRQATVPAPAPSVPEKSAKAKKKEAKRAAAAAAAEAAAAAEAAAAAAAEAAAEQKAKLKNKKQAKKTAVAVATASSSTASSNSSKSQTPQSTRESSVCSVKPKTVPKKPTSKPPKVVEVTPPPPVPEPEPEPPKRQKRLKSRLDPGQLDNNPWKALHMQDSSEGEWETGSESDEGVPTPAQPPIRQQPKLPAAPAPKPVAPSVVTKAKPAPAAVAAPAKKVKQQEAPAHQKQPAAKTQAQPKSKSTFASVGKSNPPQQQQQQYQQEKVPPTKSQQQRPAESSRKQKQAPGNLESNRSAPNQRCEHLQTQQAPRSGRVNGRTKPTPGGQQQPVQQHSNAHAAESIAPPKKSQRGKRGHRQKQEDLSGIPHNMGYFNPNEIAIPPQSGSYASTLAQQLQHLRISQPGGSSNSKEASQSPNCSIMDQLNRGVQVEHLSLPPGITLTKVDPAKSEQLRQKSESIRLLSKPLAEQQQQQHHFQQQSHLLAGYYGAAGAAGMDPNGVIMVEANPRPNRSQAPVAPPNVAAAASAASANGKASRRRRRNRGKSGGGSGGNPGSSGAANKQRTGGEGGGSAAGAADGQILANSPATAATIEANASGNIITLRNPMFHQGNGPVAGGGMMPPNPNPMPPVRSFGAGLPVPPAMSLDQPAAIIKNENGMFTIRNPALHQAVTNGLAMGGYRQFGGNVNYYTPQEAVAEAARAAQQKLQQQQQAGSAAPVAHGGGDSSNFSYFSSGSASGNGSGSSNGGNGTHNNISISCTNVPPTSAESPGRLVGEAAVIARPKHSQKCLSAIGSELKQKASKWPCFGQQQQQQQQQQDYSNSAGGSTSGVPLQEQYQQSSYYNGFEVFSAAAATASHGPGNGGVSTDCHMHHNCGDDSPPPTITGFNSYLEGIPNTGVIRYDDAAFLKNLIPGQHLNNEVSIHNISESNFTRNNASPSPHHVEITSVFGNRARSSNAYDPQQQPPPVPGANYCDNVAADYGSDSHLFVQNNLLTRMAQPAVPPDPFGYDFDPSSVVPGGGSKAASVASDLNEFLRRSPLSQRTSPYSQDENAAALETFVQNMNALQIATDAECSRLNGTGTGGGPSDVASADATAGGAANAAAAWW", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .*: .: : : .. .... *.. . . . . . :. . : * * . : * : .::: :. : . . . . :. : * ..:: :: * : : *: : :. : . :.. :: :: : : :.:.. :.* ** :. * :.: : * .: . * .. : :. : . ::: : . : : .*.:::: :*: * * ::.** * ::**:.*:**:::* * ::**:: **: : .. *..::: . ..::: : . * : :: : :.. : * : : : . : : . .* *::. :*:.:.*: : . ::.* . .. : * :** :...* * **:: * .* :. : :: *. .. : : .: :*.*: ****: *. * * .** : *.: :. : : :. . .: :. .:*. * :.: : ..* . :. .*: . . : ..* * . : *. . .: : *: .: . . .: .. : . : : ** * : *:: .:** * .:* *. *:* . ..:. .: . : : :.. : : .: . :. ** . : : * : : . :. .. ::*:: .: *: ::: ::: :.: :* ...:.** .*:.. *: : :: : .* .*: :.::. . .: .: :. :. *:: : ... . .: ..:.:: * . . : . : :.*. ::*:.:*..*. . :.. *.. : * *.. .. : .: :::*: ** : :: * * : : . .* : : : . * :.:: : * :.* : :.*: : : .: : : : *: ::::: . ::. :** * *: : : : : :. : . . : . . : : . . . * . . : . * :: . . . : :* : : .:. . : .: .: . . . . :.. : . .. :: : *. .. ::. : .* : .:. * : .. : : . : : *. :: . . : . .. .. ", "identical_positions": 124, "similar_positions": 507, "identity": "5.0%" }, { "cls_id": "homologset.agr.HGNC:16823", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B0BN86-1", "uniprot_id": "TMM11_RAT", "id": "B0BN86-1", "name": "Transmembrane protein 11, mitochondrial", "aln": "MAAWGRRRLGPG--GGSSRERVSLSATDCYIVHEIYSGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKVYELYAV--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BK08-1", "uniprot_id": "TMM11_MOUSE", "id": "Q8BK08-1", "name": "Transmembrane protein 11, mitochondrial", "aln": "MAAWGRRRLGPG--GGGSRERVSLSATDCYIVHEIYSGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKVYELYAV--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P17152-1", "uniprot_id": "TMM11_HUMAN", "id": "P17152-1", "name": "Transmembrane protein 11, mitochondrial", "aln": "MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NWH5-1", "uniprot_id": "TMM11_DANRE", "id": "Q6NWH5-1", "name": "Transmembrane protein 11, mitochondrial", "aln": "MASLGRRRGVPV-----NRERGVMAATECYIVHEIYNGENAQEQFEYELEQALEAQYRYIVIEPTRIGDETARWVAVGNCLHKTAVLAGAACLLTPLALPVEYSRYVALPAGALSLACATLYGISWQFDPCCKYQVEYDSQKLSRLPLHTLTSSTPVVLVRRDDVHRKRLHNTIALAALAYCAKKIYELYAV--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IQ56-1", "uniprot_id": "TMM11_DROME", "id": "Q8IQ56-1", "name": "Transmembrane protein 11 homolog, mitochondrial", "aln": "MVSR-------------NIESTSKVPT-FHVIREVYDSSNAHERFEAELDKALEAKLDFIVIEPPRLGDETGRWIWVGNCLHKTAVATGVVSLVA--SLLWRDRPIIAAPACALSIFCTGLYTVSWNYDPCCQYQVENNDTVLEKLPLTDVSS--PVILGYSPNSKTKYLHRSVSLLSAALCAWQIWRSYNRFVHSAGSG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.: * .* ::::*:*...**:::** **::****: :*****.*:****.**: ********** :*...*.: :* :: ** .**: * ** :**::****:**** : *.:*** ::* **:* : : * **.:::* : . *. :::. * ", "identical_positions": 71, "similar_positions": 56, "identity": "35.5%" }, { "cls_id": "homologset.agr.HGNC:16824", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EP66-1", "uniprot_id": "HCAR2_MOUSE", "id": "Q9EP66-1", "name": "Hydroxycarboxylic acid receptor 2", "aln": "MSK---SDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q80Z39-1", "uniprot_id": "HCAR2_RAT", "id": "Q80Z39-1", "name": "Hydroxycarboxylic acid receptor 2", "aln": "MSK---QNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P49019-1", "uniprot_id": "HCAR3_HUMAN", "id": "P49019-1", "name": "Hydroxycarboxylic acid receptor 3", "aln": "MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.: .:*** *: ********: *************:*******************************************: * **:. **:**.****::***:*************************** ****** *******:***:*:******* ..:: :** * :* *****:.****:***********.******.**************.******.*********:*******.***:*****:. ..:**::* ******* ***************************** *****::* *****************.. *. * **:::..** **.**..**. ", "identical_positions": 282, "similar_positions": 55, "identity": "72.87%" }, { "cls_id": "homologset.agr.HGNC:16825", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96EF0-1", "uniprot_id": "MTMR8_HUMAN", "id": "Q96EF0-1", "name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8", "aln": "------------------------------------------------------------------------MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLR------------------------------CKNFRVAHFVLD--SDLVCHEVYISLLKLSQPALPEDLYAFSYNPK--SSKEMRESGWKLIDPISDFGRMGIPNRN----WTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFY-TRCVDDE----LLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNY-----------------ANIRFRFMGIENIHVMRSSLQKLLEVCE----LKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVP-YNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6TEL0-1", "uniprot_id": "MTMR8_DANRE", "id": "Q6TEL0-1", "name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8", "aln": "------------------------------------------------------------------------MEHIITPKVENVKLLNRYTEKKSALGTLYLTATHLIYVEQTSNTRKETWVLHHHILSVEKLLLTASGCPLLIR------------------------------CKTFQHLHLLFQ--KERDCQDVYQSLLRLFQPVKEEELYAFLYNPH--QNEEERRRGWELISVVNDFNRMGLSNDY----WEISHINKNFEMCSTYPSILGLPKSASVATVTGSAKFRSRGRLPVLSYYHKDTKAAICRCSQPLSGLN-SRCVEDE----QMLQAISQANPNSPFIYVVDTRPKLNAMANRAAGKGYENEDNY-----------------SNIRFQFQGIENIHVMRSSLQKLLEVCS----MKSPSMSDYLTGLENSGWLRHIKSVMDAGVFLAKAVCEERASVLVHCSDGWDRTAQVCSLACLLLDPYYRTIKGLMVLIEKEWISFGHKFSHRCGHLDSDPKEASPVFTQFLECVWQLSQQFPCVFEFNEHYLIEIHDQVYACQYGNFIGNCQKERLDMRLHEKTFSLWPHLLENQHQYRNPLYRRSLESTVLRPSTLP-LHFKFWCGMYNHYDRGMHPKQSVLDTLLTLTQRQVEGERTMTELQRQLAVADG---------------------VLPDPAGPINTHADQNNQSEK---------MPAPPVVQSNGS-----CAPLIN-----------GNVKEVGPGAENSNQEDR----------EEPAANEHDLS-----------SKDKPVFVETEHSKEEVQESS-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8MLR7-1", "uniprot_id": "Q8MLR7_DROME", "id": "Q8MLR7-1", "name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase", "aln": "MDITRFMNKFNEIERQLSPTSALRLSFDNISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVEPD--SNKETWILHMHVASIEKLPLSTTGSPLLIR------------------------------CKTFLSVTFVIP--KDSECHDVYTSLLKLFQPVSINKLYCFNYQPN--KDDFPKNAGWDYFKLEAEFKHMLVPNEA----WTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHN-NKASICRCSQPLSGFS-ARCLEDE----QMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFY-----------------ENIKFHFLGIENIHVQRASLQKVLEACE----QKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKG-VSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYINPLYK-PNVDEAIKANLAP-QCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAADDDHPLKASNMSFASLSLSAEQSSPPQALPEEINSVAVDWKPMRNVTTCSCSTPFDQFSKKTHCWRCGDIFCERCIDKN-----VALPGHDSGKPVPVCRGCFRQMQKQSP-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47147-1", "uniprot_id": "YMR1_YEAST", "id": "P47147-1", "name": "Phosphoinositide 3-phosphatase", "aln": "------------------------------------------------------------------------MEYIKIAKVSNVVLHRRGT---ATQGTLHLTTHHLIFESPQ--LSTEFWFPYPLIYGVHKNPGSTLLSKLTSTNQIQLEGTDSQNYKLYQGKDLWSFVNIKVIGKDYAVFSLDFGGDLHLQARKVYDSILNLTVLSNITQLYAFIYISNNLERKLPSPDSWDIYDPIKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVIVDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAYMTEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTSQVVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNFNDVDTNGDDLDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVYQLLTQNPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNFIQRK----------------------------RSGMNEHDQNLEEE-----------EKVEWISPDLKKVQWWWQLYGRKDSEMNDELRHKRDSVPISVDKKSKEHS------------NSDGGKGLN--------------LSIFGFDMFNRK-----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **.** : * .: * *:**: ***: . .* *. : :.* :: . * * : : : . .:.** *:*.* .**.* * .: . . .*. . :* : : . * : *.::*:* *** : :*:..: : :::***: *:***:* :: ... * *.****.*: *.::** :::: : : :**:**: **:*: * * * ** * .: * **:***: : : *. : * . : . : *.**: ::.: :: ::: .*:**********:** *: : *:*:***::*: *:**:* ::**:* .*.**:: * : . : . :: .: .: :: : .. : .: .:* . :::: ::: .. : :. : * :. ::: *. : . . .: : .. . .: . . :. * * . : : . . : : ", "identical_positions": 114, "similar_positions": 182, "identity": "13.56%" }, { "cls_id": "homologset.agr.HGNC:16826", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P62501-1", "uniprot_id": "T22D1_RAT", "id": "P62501-1", "name": "TSC22 domain family protein 1", "aln": "--------------------------MHQPPESTAAAAAAADISARKMAHPAMFPRRGSG----GGSASALSAAGTGVSGAAPSSEDFPPPSSLLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHHIHHGHHLHHGHHHSSHAAVASTSVPGGPPPTSPVSRKLSTAGSSDGGVPVPPTSAVSSAGLPASVMTSIRAPSTPGSIGVNS----------VTGTNATNNVNIAAVGGFSPGVA----NSVH----------PNAVSISGGPGVTSGVNVN-VLSGMGNGTISSP-----VLNAAAGITVGVVSSQQQQPQQPPPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEREN----------------------------AVPGPEGVAINKVVETVKQ-TPTEASSSERESTSGSS-----------------VSSSVSTLSHYTESVGSGE-MGAPTVVVQQQQP---LPPAPPGLQGVALQQLDFSSPG---------PQSISQSQMSQVQLQPQELSFQQKPNLQPVPLQATMSAATGIQPSPVNVVGVTSAVGQQPSISSLAQPQLPYPQPAPPVQTPLPGAPP-------------------------QQLQYG-QQQPMVPTQIAPGHGQPATQNPPSEYAQQQ-----------PIFQAAMSSGQSSSTGTGA--SVIPVAQPQGIQLPVQPTAVQAQPAGATGQPIGQAPTAVSTVPAGGQIASIG--QQANIPTAVQPPSTQ-------------VTPSVVQQGAPPSSQVVLPAPTGIIHQGVQTSAPSLPQQLVIAPQSTMVAVPPQTQGVEAVAHGVVSHQLPTGSPLPSASTISVTSQVSSAGP---------------SGMSSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIP--------------LSSTQFSTQSLAQAIGSQMEDTRRPAEPSSGGLPQTLSGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGED--------------------------------------------------------------------ESS-GASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQP--QGTTQPPAQPASQGSGSTA--------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P62500-1", "uniprot_id": "T22D1_MOUSE", "id": "P62500-1", "name": "TSC22 domain family protein 1", "aln": "--------------------------MHQPPESTAAAAAAADISARKMAHPAMFPRRGSG----GGSASALNAAGTGVSGAAPSSEDFPPPS-LLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHHPHHGHHLHHGHHHSSHAAVAGPSIPGGPP-SSPVSRKLSTTGSSDGGVPVAPPPAVPSSGLPASVMTNIRTPSTTGSLGINS----------VTGTSATNNVNIAAVGSFSPSVT----NSVHGNANINTSNIPNAASISGGPGVTSVVNSS-ILSGMGNGTVSSSPVANSVLNAAAGITVGVVSSQQQQQQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKEN----------------------------AVPATEGVAINKVVETVKQ-TPTEASSSERESTSGSS-----------------VSSSVSTLSHYTESVGSGEMMGAPAVVAPQQPP---LPPAPPGLQGVALQQLEFSSPAPQSIAAVSMPQSISQSQMSQVQLQPQELSFQQKQTLQPVPLQATMSAATGIQPSPVSVVGVTAAVGQQPSVSSLAQPQLPYSQTAPPVQTPLPGAPP-------------------------QQLQYG-QQQPMVPAQIAPGHGQPVTQNPTSEYVQQQQQ---------PIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPIGQAQTAVSTVPTGGQIASIG--QQANIPTAVQQPSTQ-------------VTPSVIQQGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLVTVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAP---------------SGMPSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIP--------------LSSTQFSTQSLAQAIGSQMEDARRPAEPSLGGLPQTMSGDSGGMSAVSDGSSSSLAAPASLFPLKVLPLTTPLVDGED--------------------------------------------------------------------ESS-GASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQP--QGTTQPPAQPASQGSGSTA--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15714-1", "uniprot_id": "T22D1_HUMAN", "id": "Q15714-1", "name": "TSC22 domain family protein 1", "aln": "--------------------------MHQPPESTAAAAAAADISARKMAHPAMFPRRGSG----SGSASALNAAGTGVGSNATSSEDFPPPS-LLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPP-SSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINS----------VTGTSTVNNVNITAVGSFNPNVT----SSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVN-ILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQ-----PTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKEN----------------------------AVPATEGVLINKVVETVKQ-NPIEVTS-ERESTSGSS-----------------VSSSVSTLSHYTESVGSGE-MGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPP------------------------QQLQYG-QQQPMVSTQMAPGHVKSVTQNPASEYVQQQ-----------PILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIG--QQANIPTAVQQPSTQ-------------VPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGP---------------SGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIP--------------LSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGED--------------------------------------------------------------------ESSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQP--QGTTQPPAQPASQGSGPTA--------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1P8T9-1", "uniprot_id": "A0A8M1P8T9_DANRE", "id": "A0A8M1P8T9-1", "name": "TSC22 domain family protein 1", "aln": "MWKLLERLEVAFPKELVLLSCVYNFVRDYTPAMNHHERSGDSGSARKMVYPMSLPRRENSSSTVGGSSTLTTSASTSLNSNNLMLADEYSPPVLIQSQTQTASSLGPQNPP--HSLSIPLQTPMLPQTLPTAVAQMKKKSGFQITSVTPAQT--SVSTNNSITEDTESCDDLDESHTEDLSSSEIMDVSLPRANNSGGPERSSSEETLNNFHEAETPGALSPNQP----PIITQAHLHGTMVNGTVHHHHHHHHHHHHHNPVSSGKTHPAGGTLIG---VPLGAPVTSVVTSSSASTGQKMPSNVVGLIENASVGTTSAIGQPLATLASGTGVISVTSGATISTGNTLTNNVSVLNSASVPVVGGKTTNSSSVNYSSALNSISNQTPNLTHVPSGIIGMGITAAATVSGSVASTGGGQMGPAVMG---QHAMPAPSVPVMSAQPQQAQVPTPASTSSRFRVVKLDSTSEPFKKGRWTCTEYYDKEAP---------------------------NVASSENAPSTRTVESIRQCVPESVAGQDRDTVSGSS-----------------VSSSAS---HYTESLGSGETGGPSTVKQTFQQP--------------------------------------------MSQMQPQDLVQVHLKTNAAAPMPATANIQ---QQPPASIGGLQTTIVQSSAPLPSHMPKLTYAQAAQSPPAQALPVVTQ------------------------QQMGYPPAQQPAAPAQVAPTHVNPLSQ------------------------------------------------------------------GGSLPSDFSQSKQILSTVPPGSTKTLPH--LSASIPPVALAGNGQ-------------MITPSSQP------PTAQPLPQGLLQP-QQTPAPQMVQVVPQLVQSTGTTLIQQTPGQQLTSQPSMEQQQQSQLGSQARGTQFVPAVTSSSVP---------------PNIQSDPQ----------------SSLFQNGSKE-----------TGPQP--------------AVSTRPSVMPLEDAQLLLLQHQALLAQTKPAGG---ESASQTGTSRGPEGSSGVNALSASASLLKSLP-----VDGEE--------------------------------------------------------------------DGSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELLERNSQLEQENNLLKNLASPEQLAQFQAQVQSGSSPPSSAQGAQQPPTPSAQLAAQNSGPSA--------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q24523-4", "uniprot_id": "BUN2_DROME", "id": "Q24523-4", "name": "Protein bunched, class 2/F/G isoform", "aln": "-----------------------MFDRTVNAKFKPASSNAGPGNNPVRRNSMLTPSRGVTIGGTGGNIRKLTKVSS-LTSNHHFAVCYPPSN--IYQNSNNAGSNSALQRTTSESLRLNMMSRVAAGATPTTVSRASSNSSLATSTSTSLAPKSSSSSGGSNSTPQQQQQQLVSSNNSSSSSNNSFTKASSPNNN---GARSVGGAATSAATGTTAAAGSHHHQP--------------------HHHHHHHHHHHQHHNHQQQQQQQTSLSQGHASLTVAGGSASAGGGGGGGSGSSSGTAAGGTNRKPKTTSSFEITSVTVGHPKLNAAGDTGDES-------ADDLDESHTDDNSRITDLENETPSMS---EDTFSKEEVYYANNALSTNAPVIPTSSQYGLVVVDPIAPSLGQTIQNVQVNVSDNIINVVSGAVTPGGTKKKDDIKETQHRSERFKVVKIES-TEPFKRGRWMCMDYLDHSSVGNGGNNNEKTGSSTSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQQQQQQQQQQQQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQQQQLFDSVNANAASSPNPAGDPNNMDYARTAAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGDSAVGAASNNNSAAAATGESQLSTSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPNFQLEQQQQQQQATSQIDGIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSNAAVTTGQGQTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQLQSAPSTIADPQQLMVPQQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNLNLTNTNVVATGEATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAESETESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQMEGGGPTRSTGAFSASPSIYAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPAFQRLQVPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPAAAGQAVQQQAAGAVAVTGVATSPASAVVPTSIPNGSAENGSSAVESAAVSVEQQVQQVTSAAAAAASVVTANGPMS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . . * * .*. . ..: : . .. : . *.* : . .** : : : . .. :: ..:*.: :: *. * *:..* : :. ::* .*:... **.: : : . .: ** . : . : :... :** * ** ****: **. : . . :. *.. :. : :.. . .. . : . .* . * . :. :. : . ... : .: . . . :: . : .. :: . :.**:***::* :****:*** * :: ::. * . . . :..::: . . . :: * .: .: .. * .:. : ..:* : :* :: . : . . * . * : . .: . .* : . ** : .. . * : : : .*. : :.:: . : . :* . * : .. . : * * : : :: : . . .: :* . . . ::: * .. * ..: . * : .* :. . * . . . . . . . *:. : ..* * : . ..: *:*.******************* ***********:*.**::: .:** **.:**. . * * *:* *:* .:.*.:. . . . *: ... ", "identical_positions": 120, "similar_positions": 266, "identity": "8.63%" }, { "cls_id": "homologset.agr.HGNC:16827", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62834-1", "uniprot_id": "CD123_RAT", "id": "Q62834-1", "name": "Translation initiation factor eIF2 assembly protein", "aln": "-------------MKKEHVSHCQFSAWYPLFRSLTIKSVILP-LPQNVKDYLLDDGTLVVSGREDPPTCSQPD-SGDEAEETQWSDDESTATLTAP------EFPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKSLSDIFLLFKSSDFITHDFTQPFIHCNDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKEHLQYKFLDEDFVFDIYRD-SRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGDVSEADALEQDSPAFRCTNSEVTVQPSPYLSYGLPKDFVDLSTG-EDAHKLIDFLKLKRNQQEDD-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CII2-1", "uniprot_id": "CD123_MOUSE", "id": "Q8CII2-1", "name": "Translation initiation factor eIF2 assembly protein", "aln": "-------------MKKEHVSHCQFSAWYPLFRSLTIKSVILP-LPQNVKDYLLDDGTLVVSGREDPPTCSQSD-SGNEAEETQWSDDESTATLTAP------EFPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITHDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKEHLQYKFLDEDFVFDIYRD-SRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGEVTEGDAQEQDSPAFRCTNSEVTVQPSPYLSFGLPKDFVDLSTG-EDAHKLIDFLKLKRNEQEDD-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75794-1", "uniprot_id": "CD123_HUMAN", "id": "O75794-1", "name": "Translation initiation factor eIF2 assembly protein", "aln": "-------------MKKEHVLHCQFSAWYPFFRGVTIKSVILP-LPQNVKDYLLDDGTLVVSGRDDPPTHSQPD-SDDEAEEIQWSDDENTATLTAP------EFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRD-SRGKVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTG-EDAHKLIDFLKLKRNQQEDD-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PC40-1", "uniprot_id": "CD123_DANRE", "id": "Q6PC40-1", "name": "Translation initiation factor eIF2 assembly protein", "aln": "-------------MKKEQVVNCQFSVWYPLFKKHTIKSLILP-IPQNVIDYLLDDGTLVVSGSENNNSQTQANNSDSDEEDIQWTDDETTTTVTAP------EFPEFNVKVQEAINVLGGCIFPKLNWSAPRDANWIALNSSLQCQSLSEIFLLFKSSDFITHDLTQPFLHCSDDSPDPTINYELVLRKWSELIPGGEFRCFVKENKLIAICQRDYTQHYQHIGKQEASISTSILQFFRDNIQYQFPDEDFVLDVYRD-SSGRVWLIDFNPFGEVTDSLLFTWEELTSGKNLTANQTQEETALPDGPAFRCTNSEVTVQPSPCLSYRIPRDFLDLTTG-EDAYKLIDFLKLKRGQQEEEEESNEEGEEPQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q05791-1", "uniprot_id": "CD123_YEAST", "id": "Q05791-1", "name": "Translation initiation factor eIF2 assembly protein", "aln": "MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELG-AVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLN-YYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELR------LVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.: :* :*.:* * .:: . **::* :*::. :** :** : . :. :: ..: : :* *** *:* . :***: ::::*:* ** .: *********** ** *.:::*: :.:::**:::*::* :*: :.* * *.. ::::****:*.:: *. *** ***: :::. *** . :*:::.: . : * ::.:. : :* *:.**:*:* . .:::::*:***.. ******:*:*: : : : : : :. . .. . :*:*::: : . * :* : * .:* .: ", "identical_positions": 89, "similar_positions": 133, "identity": "24.05%" }, { "cls_id": "homologset.agr.HGNC:16828", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0KZS9-1", "uniprot_id": "A0ABK0KZS9_RAT", "id": "A0ABK0KZS9-1", "name": "", "aln": "MSMILFASIVRVRDGLPLSASTDFYHAQEFLECRRQLKALAQRLAQHPGRGSAESCDFRIYFLSSGDVACMAICSRQCPAAMAFCFLEALWWDFIASYDTTCIGLASRPYTFLEFDSVIQKTKWHFNHMSSSQMKSGLEKIQEELKSQPPAVVSLEGTDVANGLLNGHAPAHSEPAPNLRMKPVTALGVLSLVLNIMCAALNLIRGVHLAEHSLQVAQEEVGNILAFFIPSVACIVQCYLYLFYSPTRTLKVLLMLASICLGNAYLHGLRNTWQILFHVGVAFLSSYQILTRQLQERQSDYGV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BXT9-1", "uniprot_id": "SC22C_MOUSE", "id": "Q8BXT9-1", "name": "Vesicle-trafficking protein SEC22c", "aln": "MSMILFASIVRVRDGLPLSASTDFYYAQEFLECRRQLKTLAQRLARHPGRGCAESCDFLIYFSSSGDVACMAICSRQCPAAMAFCFLEALWWDFIASYDTTCVGLASRPYAFLEFDSVIQKTKWHFNHMSSSQMKSGLEKIQEELEFQPPAVLSLEDTDVANGMLNGHTPVHSEPAPNLRMKPVTALGVLSLVLNIMCAALNLIRGVHLAEHSLQVAQEEVGNILAFFIPSVACIVQCYLYLFYSPARTLKVLLMLASICLGNAYLHGLRNTWQILFHVGVAFLSSYQILTRQLQERQSDYGV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BRL7-1", "uniprot_id": "SC22C_HUMAN", "id": "Q9BRL7-1", "name": "Vesicle-trafficking protein SEC22c", "aln": "MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQKVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDVANGVMNGHTPMHLEPAPNFRMEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAHEEIGNILAFLVPFVACIFQCYLYLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSYQILTRQLQEKQSDCGV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QFN4-1", "uniprot_id": "E9QFN4_DANRE", "id": "E9QFN4-1", "name": "", "aln": "MSLILFAFVVRVRDGLPLSASTDFLHNKELQEKKQQIKIISKSLNVLPERGTVKGHELNIHFLSCEGVSYMSVCACTLPAATAFCFLEDLRWEFTACFDNSAVAMANRPYPFLEFDSAIQKLQQHYNQKGGPSLEVTLAEVQEDLRSSPPQVLTMEDVVLSNGAANGHVEQTTASGQSQRLEPVSAPGILSLVLNIMCAALNLIRGVHLIEYTFQDDYDGLWNVVAFLVAFLCCVCQCHLYLFHTCQKRLKSFTLLTLIVLCNAFLFGPRNIWQLVFHLSVACLSTLLTLHRKLQDRNTDCGV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*:** :*************** : ::: * ::::* :: * * ** .:. :: *:* * .*: *::*: *** ****** * *:* *.:*.:.:.:*.***.****** *** : *:* ....:: * ::**:*. .** *:::*.. ::** ***. .. . *::**:* *:***:**************** *:::* : : *::**::. :.*: **:****:: : :* . :* * * * :*.* ** **::**:.** **: * *:**::::* **", "identical_positions": 134, "similar_positions": 96, "identity": "44.22%" }, { "cls_id": "homologset.agr.HGNC:16829", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B0BND5-1", "uniprot_id": "B0BND5_RAT", "id": "B0BND5-1", "name": "U3 small nucleolar RNA-interacting protein 2", "aln": "MNSMSTAVATRKRAKPAPGPGAAPVDGKRRRKVDSAASRGKSKGGGK-MNEEISSDSESESLAP-RKTEEEEEEELEETAQEK------KLRLAKLYLEQLRQ---QEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPAPTD--IRVLRGHQLSITCLVITP---------------DDLAIFSAAKDCTIIKWSVETGRK-----------LHVIPRAKKGTQGQPSGHSSHILCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG--HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG------------------------------------HQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEP---------------------GLEQPFWISSVAALLNTDLVAT---GSHNACVRLWQCGEGFRQLDPLCDIP-LVGFINSLKFSSGGDF------LVAGVGQEHRLGRWWR-IKEARNSVCIIPLRRVPVSPVAGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WM3-1", "uniprot_id": "U3IP2_MOUSE", "id": "Q91WM3-1", "name": "U3 small nucleolar RNA-interacting protein 2", "aln": "---MSTAVATRKRAKPAPGPGAAPVAGKRRRKVDSAADRGKSKGGGK-MNEEISSDSESESLAP-RKTEEEEEEELEETAQEK------KLRLAKLYLEQLRQ---QEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTD--IRVLRGHQLSITCLVITP---------------DDLAIFSAAKDCTIIKWSVETGRK-----------LHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG--HRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG------------------------------------HQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEP---------------------GLEQPFWVSSVAALLNTDLVAT---GSHNARVRLWQCGEGFRQLDPLCDIP-LVGFINSLKFSSAGDF------LVAGVGQEHRLGRWWR-IKEARNSVCIIPLRRLPVSPVAGS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43818-1", "uniprot_id": "U3IP2_HUMAN", "id": "O43818-1", "name": "U3 small nucleolar RNA-interacting protein 2", "aln": "---MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGK-MNEEISSDSESESLAP-RKPEEEEEEELEETAQEK------KLRLAKLYLEQLRQ---QEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASAD--IRVLRGHQLSITCLVVTP---------------DDSAIFSAAKDCSIIKWSVESGRK-----------LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG--HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG------------------------------------HQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP---------------------GLEQPFWISSVAALLNTDLVAT---GSHSSCVRLWQCGEGFRQLDLLCDIP-LVGFINSLKFSSSGDF------LVAGVGQEHRLGRWWR-IKEARNSVCIIPLRRVPVPPAAGS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R8RL46-1", "uniprot_id": "A0A2R8RL46_DANRE", "id": "A0A2R8RL46-1", "name": "U3 small nucleolar RNA-interacting protein 2", "aln": "---MSSFFIKKKLVSSATN------KGDLKRKSNTDDGKGRSKRFSKRMNEEISSDSENESADPGRKQQENEEDEIEETAQEK------KLRLAKLYLDQLRE---EEDKKAEEESFEADLIAGRLQEDVLEQKGKLQRLIAKELKAPDPAE--IRLLRGHKLPVTCLVITP---------------DEKHIFSASKDCSIIKWDVESGKK-----------VQKIAGGRKGTED---CHTAHILCMAISSDGKYLASGDMNKHIMIWDPETCKHLFKFTG--HRGAISGLAFRRGTHTLYSASHDRSIKVWSVDENAYVETLFGHQDAITGLDCLSRERCVTTGGRDRTVRVWKIAEESQLVFHG------------------------------------HEGSIDCVQLINEEHMVTGGDDGAVSIWTVNKKKPLSSVKQAHGVRGSA---------------------GLEQPYWVSSVAALHNSDTVASGASGSHNSSVQLWKCGQGFRGLELLFSVP-VNGFVNSLKFSNSGKF------LVAGVGQEHRLGRWWR-IKEAKNGLYIIPLKRQAKEQEVVQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q06506-1", "uniprot_id": "RRP9_YEAST", "id": "Q06506-1", "name": "Ribosomal RNA-processing protein 9", "aln": "---MSDVTQQKKRKRSKGEVNPSKPTVDEEITDPSSNEDEQLEVSDE--EDALESEEEFEGENPADKRRRLAKQYLENLKSEANDILTDNRNAEEKDLNNLKERTIDEYNNFDAGDLDKDIIASRLKEDVAEQQGRVFRYFGDKLLISEAKQSFTRVGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFIS---GSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIANVSGARNGIYSAVIDQTGF------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** :* . . . . : : : .: :: :.*:.* *. * * .. :: :*: .* : . : *::*:: :* :: : :: * :*.**:*** **:*:: : ...:: . . : *: ..: ::*: . . ::.:** : *:.: * : *. .:: :. * .:* :* *.****:.:*. .: :::*..:: . : :. :*. : .****:.:. **::. * .::.:. : : :* *:**:* : :..*: * ***.*.** *. :***.:*::*.* * :**** : :::: *:::*.*:* :.:* : **:*: : ***: .. * **:*::*: *: :: . : ** .. :::*: .:.:* :: * .:. *.:..::. ..*.. ::*.:.:******* :. *:*.: : : ", "identical_positions": 107, "similar_positions": 202, "identity": "18.23%" }, { "cls_id": "homologset.agr.HGNC:1683", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P10252-1", "uniprot_id": "CD48_RAT", "id": "P10252-1", "name": "CD48 antigen", "aln": "MYFKKRRWFLILESLLLS---LVTGFQDQSVPNVNAITGSNVTLTILKHPLASYQRLTWLHTTNQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDRGDYYMRMLHET--EDQWKITMEVYDLVSKPAIKIEKTKNLTDSCHLRLSCKVEDQGVDYTWYEDSGPFPQRNPGYVLEITITPHNKSTFYTCQVSNPVSSENDTLYFIPPCTLARSSGVHWIAAWLVVTLSIIPSILLA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P18181-1", "uniprot_id": "CD48_MOUSE", "id": "P18181-1", "name": "CD48 antigen", "aln": "MCFIKQGWCLVLELLLLP---LGTGFQGHSIPDINATTGSNVTLKIHKDPLGPYKRITWLHTKNQKILEYNYNSTKTIFESEFKGRVYLEENNGALHISNVRKEDKGTYYMRVLRET--ENELKITLEVFDPVPKPSIEINKTEASTDSCHLRLSCEVKDQHVDYTWYESSGPFPKKSPGYVLDLIVTPQNKSTFYTCQVSNPVSSKNDTVYFTLPCDLARSSGVCWTATWLVVTTLIIHRILLT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P09326-1", "uniprot_id": "CD48_HUMAN", "id": "P09326-1", "name": "CD48 antigen", "aln": "MCSRGWDSCLALELLLLPLSLLVTSIQGHLV-HMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWD-SRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * ** ***. * *.:*.: : .:.. :******.* : *:::**::* :***:*: . ... *** **.** *: .*** * :* ***.. * **:*::* *:: **.::* * *.** *:*:* : *.*:*:*** : .: *:**** .. ***:. . **: : *:* * *******.***:*.*: : ** **** ** * *:***** * :**:", "identical_positions": 106, "similar_positions": 66, "identity": "43.27%" }, { "cls_id": "homologset.agr.HGNC:16831", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JIR0-1", "uniprot_id": "RIMB1_RAT", "id": "Q9JIR0-1", "name": "Peripheral-type benzodiazepine receptor-associated protein 1", "aln": "MEQLTTLPRLGDPGAMEPWALPAWQHWTQGQGCKPGDASASIAATP-TALQVKGLRFEESSEPAGAHSPGPIRNTDPEGTETVLPKLGQQAESPGYSCSRLEGEDAQAY-KAKFNIGFGDRPNLELLRALGELQQHCTILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRGGEVPLCPDPDPVWSCARKALARQRARDLSETATALLAKDKQNAALQRECRELQARLSLVGKEGPQWLHMRDFDRLLRESQREVLRLQRQIALRNQRE--PLRPARSQGSTAPSSVGAPAPGAPGETVLEDDVESPQVVLGEPEKQLRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGKATEKEQVEWENAELKGQLLGVTQERDSALRKSQGLQSKLESLEQVLEHMRKVAQRRQQLEEEHEQARLSLQEKQEEVRRLQQAQAEAKREHEGAVQLLESTLDSMQARVRELEGQCRSQTERFSLLAQELQAFRLHPGPLDLLTSALGCNALGDHPPPHCCCSSPQPCQGSGPKDLDLPPGSPGRCTPKSSEPALATLTGVPRRTAKKAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEVDSVSLLPAAPEGHSGGGARIQVFLARYSYNP-------FEGPNENPEAELPLTAGEYIYIYGNMD-EDGFFEGELMDGRRGLVPSNFVERVSDDDLLSTLPRELADSSHSSGPELSFLSGGGGGCSSGGQSSGGRSQPRPEEEATGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELPPER--VDLRGFHIFVNGELRQALGPGVPPKAVLENMDLRAGPLHVSVQALTS-KGSSDPLRCCLAMG-AGAGVVPSQLRIHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCNLRPGTLYQARVEAQIP------------SQGPWEPGWERPELRAATLQFTTLPAGLPDAPLDVQAEPGPSPGIVMISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTVRTMSPHGESTDSIPAPVAPALASACQ---PARMSCLSPRPSPEVRTPLASVSPGLGYTSLPLRHPVPHGTQDSP----ASLSTEMSKGPQEEPPVPCSQEEAGSAVHRTSEE---KRAMEPTLGQEGPDPVAPFLAKQAVECTSGDAGPTPCSTQEELTQKEPSTEVCHRGDLDSELKLRSEKEGMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEEEEE--LGSRPWSFQKQVAGNSIGENGAKPQPDPSCETDSDEEILEQILELPLQRLCSKKLFSIPEEEEEEDEEEGLGKPGPSSSSQDPSQPERALLGLDCESSQPQGPGL---CPLSPELSGAREHLEDVLGVVGGNSRRRGGCSPEKLPNRKRPQDPREHCSRLLGNGGPQTSARPVPPRDRGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDSED-EQEVGSGGVSISSSCYPTDGEAWGTAAVGRPRGPVKVNSGSNTYLRLPAWEKGEPERRGRSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVLRTGTTELAPPRSPQEAPSHQDLPLRVFVALFDYDPISMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAEVAVDTPTGRQQLLQRGFLPPNVLTQGSGNGPSVYPSAHTPGP-PPKPRRSKKVELEDPAQLCPGPPKLIHSAALKTSRPMVAAFDYNPRENSPNMDVEAELPFRAGDVITVFGNMDD---DGFYYGELNGQRG-----------LVPSNFLEGPGPEA---GGLDSG--TSQAESQRTRRRRVQC--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TNF8-1", "uniprot_id": "RIMB1_MOUSE", "id": "Q7TNF8-1", "name": "Peripheral-type benzodiazepine receptor-associated protein 1", "aln": "MEQLTTLPRLGDLGAMEPWALPAWQHWTQGQGCKPGDASPSIAGTP-TALQVKGLRFEESSKPEGAHSPGPVGNTDPEATETGLPKLGQQAESPGYSCSGLEEEEAQAY-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRVVSAP-VPRPGSSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLSLVGKEGPQWLHMRDFDRLLRESQREVLRLQRQIALRNQRE--PLRPARSPGPTAPSRVGAPAPGAPGEAVLQDDVESPQVVLREPEKQQRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRATEKEQVEWENSELKGQLLGVTQERDSALLKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQEKQEEVRRLQQAQAEAKREHEGAVQLLESTLDSMQARVRELEGQCRSQTERFSLLAQELQAFRLHPGPLDLLTSALGCSALGDHPPPHCCCSIPQPCQGSGPKDLDLPPGSPGRCTPKSSEPALTTLTGIPRRTAKKAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEVDSVSLLPAAPESHSGG-ARIQVFLARYSYNP-------FEGPNENPEAELPLTAGEYIYIYGNMD-EDGFFEGELMDGRRGLVPSNFVERVSDDDLLSTLPRELADSSHSSGPELSFLSGGGGGCSSGGQSSGGRSQPRPEEEAAGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELPPER--VDLRGFHIFVNGELRQALGPGVPPKAVLENMDLRTGPLHVSVQALTS-KGSSDPLRCCLAVG-AGAGVVPSQLRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEAQIP------------SQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPGPSPGILMISWLPVTIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTVRTMSPHGESSDSIPAPVAPALASACQ---PARMSCLSPRPSPEVRTPLASVSPGLGDTSFPLRHPVPHGTQDFS----ASLSIEMSKGPQEEPPVPCSQEEAGAAVRSISEE---KRAIEPTLGQEGPEPVAPSLAKQEVECTSGDAGPVPCSTQGELTQKKPSIEACHGGDLDSGLKLRSEKEDMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEEEEEE-LGSRPCSSQKQVAGNSIRENGAKPQPDPFCETDSDEEILEQILELPLQRLCSKKLFSIPEEEEEEEEEEGLEKPGPSRTSQDPSQPELALLGPGCDSSQPQGPGL---CPLSPELSGVREHLEDVLGVVGGNGRRRGGGSPEKLPNRKRPQDPREHCSRLLGNGGPQASARPVPPRERGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDSED-EQEAGSGGVSINSSCYPTDGEAWGTAAVGRPRGPPKVNPGPNAYLRLPAWEKGEPERRGRSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVPRSGTTELAPPRSPQEAPPHQDLPVRVFVALFDYDPVSMSPNPDAGEEELPFKEGQLLKVFGDKDADGFYRGESGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGFLPPNVLTEASGNGPSVYSSAHTPGP-PPKPRRSKKVELEGPTQLCPGPPKLIHSAAQKTSRPMVAAFDYNPRENSPNMDVEAELPFRAGDVITVFGNMDD---DGFYYGELNGQRG-----------LVPSNFLEGPGPES---GSLESG--TSQAESQRTRRRRVQC--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95153-1", "uniprot_id": "RIMB1_HUMAN", "id": "O95153-1", "name": "Peripheral-type benzodiazepine receptor-associated protein 1", "aln": "MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP-LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGG-ARIQVFLARYSYNP-------FEGPNENPEAELPLTAGEYIYIYGNMD-EDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQ--VELHGFHICVNGELRQALGPGAPPKAVLENLDLWAGPLHISVQALTS-RGSSDPLRCCLAVG-ARAGVVPSQLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLP------------PQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASL---PARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEE---RTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQ---CPLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQASGRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIEYDSED-EQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEPERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGP-PPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDD---DGFYYGELNGQRG-----------LVPSNFLEGPGPEA---GGLDREPRTPQAESQRTRRRRVQC--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4JDC9-1", "uniprot_id": "A0A0B4JDC9_DROME", "id": "A0A0B4JDC9-1", "name": "", "aln": "---------------MHLCEFPSANVEEENRRPEKAAAAASKKQKHKQQKSRPRGSHSMPYESMHHHQSAAAAVAAGTTPNGMLDALSLQLRDAEMRRTEIERAHQETLAQIRN-LSGSARPDAEAVENL---QSRARELEKKVALENVRCEELQIELTSALKAKQASRSACSG--------MGSVSSGGGATIPTSASSSTVTWAPTISHQDQGSEIDIIMAKIEQDNRVLAELEQPRTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAVLGGSGGGGGGVGGGGGGVSALSSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISALVPNSISGISSSLSSHAIQSMQYGTGQTSVEKLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGG--TSLTHPTMANLGLLDTGTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSAS-------YPFTAAALRQASKMKMLDEIDIPLTRYNRSSP--CSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEPQVDMLDIP------------GKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCDTTSLPSLPPHNPLLTHTHEDLARLSETHTDLEHD--QDDISDN--VPAPKHLTLERQLNKSVLIGWSPPEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDSTR-PHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQE--EAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVNRPTSTGP----VTGYAVYADGKKVTDINSPTGDHALIDIGKLGVFNP-RAVTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQMGMGPQLPQGPHGMTVQQQMGGMPGQPGQQGQHMMGGQQDHG--QYDPNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGGLFSKPTQNQVNQNGYQPGQPGAQRGMVPIPGRPQGPQ-QQQQQPYGPQGPMGGPRFRGPVPGQLNMQGQ-----QMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMP--GQMAGQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLNQQQQQ-QQQMQQGQMMPGQQAGQQQAQPGQPGQPGQMPGAQKKPRYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEVEDTTASMTAGGQMPGQMPGQMGQGQGVGVGGTAQVMPGQGAPQQ-SMRNVSRDRWGDIYANMPVKRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAPDQYNNQMGPGGVAGRGGLSQRGRGQGPGARGPPP-PPRDNMMPGMGGRGQPGKNARPASPTLLDNTGHPAPDHQTQGMIGRVGNVGLQQQQQQQQQQQQLQQQQQYGQQQTQMGQQQQQQQQMGQPGMMGQQMGQPMGQQMGQMGQMGQMGQQQMGQQQMGQQQQPPTTQAQTGGLFSGATSLLSGATSAATGGLFGSKQPPKTDPMQPQGGVQPAQQQANAFGAQQPGMGMQQQGGMQSGMQQGMQQGMQQGMQQGMQQGMQQGMQQGMQQGMQPGMQQQQQQPQQVPPQAQAPPPGPGAGLLGGLKGIAAAAPGGDVLSKGKDLFGKFGFGFGK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12234-1", "uniprot_id": "RUD3_YEAST", "id": "Q12234-1", "name": "GRIP domain-containing protein RUD3", "aln": "------------------------MGKNKKKTGKKAKSHPHVEDVDETVNKPEEIINSVNVTVPPKMSTDPEADGIVASPDDEGKDLSEGVDKQKVNDG--------------------------------------LTVDTINPLEDKKAGDEMKELREEIERLKLELS-----------------------------------HKKDQETPNEDFKNELANVIKERDEFKTQYDTLLSKISSMKSIFNKMKEAQKQLEEVQEQLTEYESQNLKLKKKLEATKTEN---------------------------------------------------SELQSTIVTLNTELENLEKEQESTEEVFLEYESRIEALEDEKHDIIEKHSKELNTYRKEK----------------------------------DQLNLQVQELMIILENNKQDISDLRTERDELR--------------QALESHEKEKAVLKNSLNDLELKIEEVDNKREEEARERD---QEVKSLRSQLD----------------------------------------------------------------------TEIETHNNDTEALESMKKQLEAMKEDAS------------------------------MKEKYEEES-----------------------KQHILQIGKLR-HEAIILNEHLTKALAMLKKSSDSESVDKELISNLLISFVSIPRAD-------------------------------------------------------PRKFEVLELLSN--FLNWDEDKKQ-------------------------------------------------------------------------------------------------QAGLISNNESKNSSAVSRTESFVSLWTNYLEKESEKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . : . . . .. . .: *. . :. : . * :: : . : . . . : :. : : . .: : . :. . : *. :: : . : .. : .. . ::. . . :: : : : : . :: * : : .. *..: . . .: . : :. :: . : : : :: :. ::: . . . : * : .:: . .. ..:*: : :. *::: : . * : .: *. :. :.. * . :: * .. : . ", "identical_positions": 12, "similar_positions": 133, "identity": "0.63%" }, { "cls_id": "homologset.agr.HGNC:16832", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P50408-1", "uniprot_id": "VATF_RAT", "id": "P50408-1", "name": "V-type proton ATPase subunit F", "aln": "-----MAGRGKLIAVIGDEDTVTGFLLGGIGELN-KNRHPNFLVVEKD---TTINEIEDTFRQFLN-RDDIGIILINQYIAEMVRHALDAHQRSIPAVLEIPSKEHPYDAAKDSILRRAKGMFTAEDLR-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D1K2-1", "uniprot_id": "VATF_MOUSE", "id": "Q9D1K2-1", "name": "V-type proton ATPase subunit F", "aln": "-----MAGRGKLIAVIGDEDTVTGFLLGGIGELN-KNRHPNFLVVEKD---TTINEIEDTFRQFLN-RDDIGIILINQYIAEMVRHALDAHQRSIPAVLEIPSKEHPYDAAKDSILRRAKGMFTAEDLR-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q16864-1", "uniprot_id": "VATF_HUMAN", "id": "Q16864-1", "name": "V-type proton ATPase subunit F", "aln": "-----MAGRGKLIAVIGDEDTVTGFLLGGIGELN-KNRHPNFLVVEKD---TTINEIEDTFRQFLN-RDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24583-1", "uniprot_id": "VATF1_DROME", "id": "Q24583-1", "name": "V-type proton ATPase subunit F 1", "aln": "-MALHSAIKGKLISVIGDEDTCVGFLLGGVGEIN-KNRHPNFMVVDKN---TAVSELEDCFKRFLK-RDDIDIILINQNCAELIRHVIDAHTSPVPAVLEIPSKDHPYDASKDSILRRARGMFNPEDLVR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39111-1", "uniprot_id": "VATF_YEAST", "id": "P39111-1", "name": "V-type proton ATPase subunit F", "aln": "-----MAEKRTLIAVIADEDTTTGLLLAGIGQITPETQEKNFFVYQEGK--TTKEEITDKFNHFTEERDDIAILLINQHIAENIRARVDSFTNAFPAILEIPSKDHPYDPEKDSVLKRVRKLFGE-----", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VNL3-1", "uniprot_id": "VATF2_DROME", "id": "Q9VNL3-1", "name": "V-type proton ATPase subunit F 2", "aln": "MSTPTHNLPRTRVSAFCWVALERSTRIERPTSWSWKELSHYSLIVFHCIPDTTPKQIEECFKKFLR-RPDIVIILINQVYADMIRPTVDAHNLAVPTVLEIPSKQHPYDSSRDSILKRAQRVITPPERHY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . ::.: . : . . : :: . *: .:: : *.:* . * ** *:**** *: :* :*:. ..*::******:****. :**:*:*.: :: ", "identical_positions": 29, "similar_positions": 40, "identity": "22.31%" }, { "cls_id": "homologset.agr.HGNC:16833", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JLY0-1", "uniprot_id": "SOCS6_MOUSE", "id": "Q9JLY0-1", "name": "Suppressor of cytokine signaling 6", "aln": "MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKG-KNRSKSESLMGTLKRRLSAKQKTKGKGGT---ASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGP-VNGVRKDLRELQP--------------RELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZS84-1", "uniprot_id": "D3ZS84_RAT", "id": "D3ZS84-1", "name": "Suppressor of cytokine signaling 6", "aln": "MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKG-KNRSKSESLMGTLKRRLSAKQKTKGKGGT---APTDEDAFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGP-VNGVRKELRELQPKELRDLQPRELLQPRELRDLQPEPRPESRCSPSSPGELSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGTFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O14544-1", "uniprot_id": "SOCS6_HUMAN", "id": "O14544-1", "name": "Suppressor of cytokine signaling 6", "aln": "MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS-----------------ETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "********:******.***:**:***** ***.** *******************..***** **********************:***.** :.:***:***:*** :***** ***************:*******.*********:*******::**.* :*****::::**. . * . :.*.* *:* ***:**********.***:*******:** ****.** ***:********** .. :*.**:*:*******.***:**.***.**************.****.************* ********:*.: *:***:***************************************************************************************************************************************************************************************************", "identical_positions": 449, "similar_positions": 56, "identity": "81.34%" }, { "cls_id": "homologset.agr.HGNC:16834", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80Z34-1", "uniprot_id": "NREP_RAT", "id": "Q80Z34-1", "name": "Neuronal regeneration-related protein", "aln": "MVYYPELLVWVSQEPFPYKEMEGGLTKGRLPVPKEVNRKKMDEPIAASLIPPGNHEPGSPAIGYLHPF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q07475-1", "uniprot_id": "NREP_MOUSE", "id": "Q07475-1", "name": "Neuronal regeneration-related protein", "aln": "MVYYPELLVWVSQEPFAYKEMEGGLIKGRLPVPKEVNRKKMEETGAASLTPPGSREFTSPATSYLHPF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q16612-1", "uniprot_id": "NREP_HUMAN", "id": "Q16612-1", "name": "Neuronal regeneration-related protein", "aln": "MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELRSPRISYLHFF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*******:********. *:*** * ************** :*. **** * *. * ** .*** *", "identical_positions": 48, "similar_positions": 7, "identity": "70.59%" }, { "cls_id": "homologset.agr.HGNC:16835", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JLS3-1", "uniprot_id": "TAOK2_RAT", "id": "Q9JLS3-1", "name": "Serine/threonine-protein kinase TAO2", "aln": "MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEE------EEAEPYMHRAGTLTSLESSHSVPSMSISASS-QSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEH---------------------TVTSHSS----------IIHRLPG----------------------------------------------------SDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYC-----RNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLP--MGLPATGALGPLSTGTLSEEQPCSSGQEAILGQRMLGEEEEAVPERM----ILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDWDISKEMKESRVPSLASQERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIGTPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFAVGSSSGLLPLLLL--LLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFLLLAQGTALGAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGG-KWVRQQGPQMRRGISRLWLRVLLRLSPMVFRALQG-CAAVGDRGLFALYPKTNK--NGFRSRLPVPWP--RQGNPRTTQHPLALLARVWALCKGWNWR------------LARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQRRLG--LSASRQLPPGTVAGRRSQTR-------------------RALPPWR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZQ29-1", "uniprot_id": "TAOK2_MOUSE", "id": "Q6ZQ29-1", "name": "Serine/threonine-protein kinase TAO2", "aln": "MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEELTPCSQEAEPYTHRAGTLTSLESSHSVPSMSISASS-QSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEH---------------------TVTSHSS----------IIHRLPG----------------------------------------------------SDNLYDDPYQPEMTPGPLQPPAAPPTSTSSS-ARRRAYC-----RNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLP--MGLPATGALGPLSTGTPSEEQPCSSGQEAILDQRMLGEEEEAVPERR----ILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLANEEDWDISEEMKEIRVPSLASQERNIIGQEEAAAWSLWEKEGGNLVDVEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIGTHRDPGDGCPSPDIPPEPPPSHLRQYPTSQLPGLLSHGLLAGLSFAVGSSSGLLPLLLL--LLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPGLFLLLAQGTALLAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGG-KWVRQQGPQMRRGISRLWLRILLRLSPMVFRALQG-CGAVGDRGLFALYPKTNK--NGFRSRLPVPWP--RQGNPRTTQHPLAQLTRVWAVCKGWNWR------------LARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQRRLG--LSASRQLPPGTVAGRRSQTR-------------------RTLPPWR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UL54-1", "uniprot_id": "TAOK2_HUMAN", "id": "Q9UL54-1", "name": "Serine/threonine-protein kinase TAO2", "aln": "MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEE------EEAEPYMHRAGTLTSLESSHSVPSMSISASS-QSSSVNSLADASDNEEEEEEEEEEEEEEE--GPEAREMAMMQEGEH---------------------TVTSHSS----------IIHRLPG----------------------------------------------------SDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYC-----RNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERR----ILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEE--GAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLL--LLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGG-RWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQG-CGAVGDRGLFALYPKTNK--DGFRSRLPVPGP--RRRNPRTTQHPLALLARVWVLCKGWNWR------------LARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLG--PPASRQPLPGTLAGRRSRTRQS-----------------RALPPWR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AY27-1", "uniprot_id": "A0A8M3AY27_DANRE", "id": "A0A8M3AY27-1", "name": "non-specific serine/threonine protein kinase", "aln": "MPSSVRAGSLKDPEVAELFYKEDPEKLFTDLREIGHGSFGAVYFAHDIRTNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTVEYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLVYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSNHWSDYFRNFVDSCLQKISQDRPTSDVLLKHHFLCRERPVTVVMDLIARTKDAVRELDNLQYRKMKKILFQETHNGPATEGTEEEE-SCVFQDVEQYMLRTGTVNSMESSHSLPSMSISASS-QSSSVNSLADGSD--------------------DSGEMAMMQEGEH---------------------TVTSNSS----------VLHKALN----------------------------------------------------HDNIYDDPYQPEMDSQQQQQQGP-------SGGRRR--------RGRDHFATIRTASLVTRQIQEHEQGSALREQMSGYKRMRRQHQKQLMALENKLKAEMDEHQLRLDKELETQRNNFGSEADKLSKKHQAILEKETKGAIAEEKKFQQHILGQQKKELTSLLESQKRHYRQRKEQLKEELNENQSTPKREKQEWLVQQKECLQQVQAEEEAGLLRRQRQYYELQGRQYKRKMLLSRHNLEQDLLREDLNKKQTLKDLECAMLLRHHESTQELEFRQLALVQRTRADLIRTQHQTELTNQMEYNKRREQELRQKHAVEVRQQPKSLRVSDSDIT---ENSTEGAGLDIEGVEPQDEEKRDGEKIDGDEMQPLGAVEETSEQEMREVNVLEENDTEETLTDQCDVIDSEGKVEELAESADNVNESADKSPKIADEEQVEDKIDNDLRQVEGLQWDGESESDSEEEDRGVADGCPSELIPGPSFERRPLERDLDELSEFYFPDTLEELEP--PPVYIPPSPSSSSQ-----PSLPSLFSHAICLVLSLSAAVQPSVLTLLLLSIFLLSLRRSPPLPSLASILLSGELAFLALFFSYLFLRSCCSLSFSTYLLLTYWGSGLFSLALSLSLGLYYVPIALISASFLSSPSLFLTLYLIVVLVVRPARVFLQNTPRKLNRLWMRVLFRLPKPLFTVCQSVLGGLTERSLYDMFPKAGRNWGGRQSRIPVPLKSLHTAQYQAKSKHSLLFARILLMGRRFVRRPLGTLTDLANSMVLHIAKRVLKELPQNYLKRLQEFGLLRKEKTSKLPVLLPRMVREHRRRMRERRETERRRRVERERMYREEGRWESVLRRTASGRSLKGKMVPWR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3AQT9-1", "uniprot_id": "A0A8M3AQT9_DANRE", "id": "A0A8M3AQT9-1", "name": "non-specific serine/threonine protein kinase", "aln": "MPASVRTGTLKDSEVSELFYRDDPEKLFTDLREIGHGSFGAVYFAHDVRSNEVVAIKKMSFSGKQSNEKWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVSPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITSIELAERKPPLFNMNAMSALYHIAQNESPVLASNHWSDYFRNFVDSCLQKIPQDRPTSDVLLNHHFLCRERPHSVVMDLITRTKDAVRELDNLQYRKMKKILFQETHNGPVQEGGEEE------EEGEQYLLQTGTVNSMESSQSVPSMSISASS-QSSSVNSLADGSD--------------------DSAEMAMMQEGEQ---------------------TVTSNSS----------IIHRPSA----------------------------------------------------RDNIYDDPYQPEMESQQP-----------ASSAARRRIH-----RNRDHFATIRTASVVTRQIQEHEQGSALREQMSGYKRMRRQHQKQLLALENKLKSEMDEHQLRLDKELETQRNNFGSEADKLGKKHLAILEKEIKGAQTEEKKFQQHILNQQKKELNSLLDNQKRQYRQRKDQLKEELSENQSTPKREKQEWLVRQKECLQQIQAEEEASLLRRQRQYYELQCRQYKRKMLLARHNLEQDLLREDLNKRQTQKDLECAMLLRHHESTQELEFRQLALVQRTRADLIRTQHQSELANQMEYNKRREQELRQKHAVEVRQQPKSLKTKELQIK-----------RQFQDTCKIQTRQYKALRNHLLETTPKSEHKTVLKRLK---EEQTRKLAILAEQYDHSIKDMLSTQAVSKLRLDETQEDEYRALRMQLQQELELLNAYQSKIKMHTDTQHEREVKDLEQRVSIRRALLEQRIEEEMLS---LQNERSERIRALLEQQAR---------EIESFDSESMRLGFSNMALSGIPAEAYNQGYSNPPSSGPGGWPSRPVP--------------RSGSQWSHGVQNSAAPPSWRSQNSTAGFSRAEQMSSRERDRDRELESMAAR----AYPGSRSSASSASSSSSSSSHHHLRYIPQQYHHQSTPHLYRDSREREWGSGGGGHHSSSSSSHGHSHHISAQSLALLPPPPPP--------PPISLS---SSSPPSSSSSSSSQSGYGGRGEGLVVR---------------GPSLMALRNSPGPLRRTASGGGAGG---SGGDGGLSRS-------TSVTSHISNGSHLSYS------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q0KHQ5-1", "uniprot_id": "TAO_DROME", "id": "Q0KHQ5-1", "name": "Serine/threonine-protein kinase Tao", "aln": "MPS-ARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAVGDTDD------QQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQN------HHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQ-EEMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIR-----------KQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLK---EEKHRKLTLLGEQYEQSIADMFQSQS---YKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQ---FNQERAERLRMKHEKHTK--------------------------ELEAFDNESIALGFS--------TLSLIEVS---------------REAYADEEGSLSGSMISLAHSNSSTSFPAGSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: *.*:***.::::** :.****:* **************:*: . *:*******::****:******:**::**::*.****::*:****** *********:*****::*******:* ****: *.*.** **** . ****:*******:: * ***.*****:* .*************************************.********* ******************.* ...**: * .**: **:*:. :**:* **.* :: * *. :*:::** ***.********:********: :: : . :: :: : :.. .*: *.:*: *:.:**:* **** **:. .:: .: * *:. .: :*: :** ::* .. * ** * . :: :. ::******:*:*::* :** * . ::**:********:** :*: **.: : : : *. *::* :: .* : ::* :* *:. : : : *:*:::.* :*::: :*: *: .*:: *.**. : *****:: * **: *:* :*:** :*: *:** **: *::*** :: :*. ::: **::*.*:: : *:**::** *:*** ** *:: * : . **::** ** :* .* ::** :***.::*******: : : . . : : . . .: : : : : . : : : : . * : : :.: * . * .: .. * . : . * : :. . ", "identical_positions": 354, "similar_positions": 242, "identity": "25.71%" }, { "cls_id": "homologset.agr.HGNC:16836", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3UR70-1", "uniprot_id": "TGFA1_MOUSE", "id": "Q3UR70-1", "name": "Transforming growth factor-beta receptor-associated protein 1", "aln": "----------------------------------------------------------------MMNIKAFTLVSAVERELLMGDRDHISIECVECCGRNLYVG---TNDCFIYHFLLEEKAMPTGTATFVATKQLHRHLGFKKP-------VNELCAASALNRLLVLCDNSITLVNMLNLEPVPSG-----------------------ARIKGATTFAVNESPVNGDPFCVEVCIISVKR-RTVQMFLVYEDRVQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNYSTGLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGH-------ILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLANRRVEEALVLAKGARRNIPK-------EKFQVMYRRILQQAG-------------------FIQFAQLQFLEAKELFRSSQ-------------------LDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKR------FLMSYLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRS--------DLYEYIVDFLTYCLD--QELVWTHADWLLQKSEEIGVQIFTKRPLDEQQQTS-FNPDNIISSLKKYPKAL-VKYLEHLVIDRRLQKEEYHTHLAILYLEEVLRQRVSTGGKDVEATETQAKLRRLLQKS-DLYRVHLLKEKVQG-AGLPMESAILHGKLGEHEKALHILVHEMGDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRAGPSAQDLTVAAVDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSERELCQLCQNPFG------EPVFVRYPNGGLVHTHCAASRHTAPSSPSPGTRT----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JV19-1", "uniprot_id": "A0A0G2JV19_RAT", "id": "A0A0G2JV19-1", "name": "", "aln": "--MSGNVVPSPCSTTCLCGFLDPPFKLRLQTLHLQKVVTANLKIESLNWGAFQQEHFMPDYAVDMMNIKAFTLVSAVERELLMGDRDHISIECVECCGRNLYVG---TNDCFIYHFLLEEKAMPTGTATFIATKQLHRHLGFKKP-------VNELCAASALNRLLVLCDNSITLVNMLNLEPVPSG-----------------------ARIKGATTFAVNENPVNGDPFCVEVCIISVKR-RTVQMFLVYEDRVQIVKEVSTTEQPLAVAVDGYFLCLALTTQYIILNYSTGFSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGH-------ILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLANRRVEEALVLAKGARRNIPK-------EKFQVMYRRILQQAG-------------------FIQFAQLQFLEAKELFRSSQ-------------------LDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKR------FLMSYLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENSCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRS--------DLYEYIVDFLTYCLD--QELVWTHADWLLQKSQEVGVQVFTKRPLDEQQQTS-FNPDDIISCLKKYPKAL-VKYLEHLVIDRRLQKEEYHTHLALLYLEEVLRQRAPTGGKDVEATETQAKLRRLLQKS-DLYRVHLLKEKIQG-AGLPMESAILHGKLGEHEKALHILVHEMGDFSAAEDYCLWSSEGQDAACRQRLFHTLLAMYLRAGPSAHDLTVAAVDLLNHHAREFDATQVLQLLPDTWSVQLLCPFLTGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGSAIWLSEKKLCQLCQNPFG------EPVFVRYPNGGLVHTHCAASRHTNPSSPSPGTRT----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WUH2-1", "uniprot_id": "TGFA1_HUMAN", "id": "Q8WUH2-1", "name": "Transforming growth factor-beta receptor-associated protein 1", "aln": "----------------------------------------------------------------MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVG---TNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKP-------VNELRAASALNRLLVLCDNSISLVNMLNLEPVPSG-----------------------ARIKGAATFALNENPVSGDPFCVEVCIISVKR-RTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGH-------ILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPK-------EKFQVMYRRILQQAG-------------------FIQFAQLQFLEAKELFRSGQ-------------------LDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKR------FLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRS--------DLYEYIVDFLTYCLD--EELVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNS-FNPDDIINCLKKYPKAL-VKYLEHLVIDKRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKS-DLYRVHFLLERLQG-AGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFC------EPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A4IG72-1", "uniprot_id": "TGFA1_DANRE", "id": "A4IG72-1", "name": "Transforming growth factor-beta receptor-associated protein 1 homolog", "aln": "-----------------------------------------------------------------MSVKAFDLVPAVEREQVMGEKVRINIECIECCGQHLYLG---TNDCFIHHFLLEEHTTAKGKLAFNAQKLLHKYLGLKKP-------VVELKAASALERLIVLCDSAITVVDMVTLEPVPTGG----------------------AKLKGVTAFCINENPVTGDAFCVEMAVVLARR-RAVQICTVHEDRVQMLKEVTTPEQPCALSLDGYNICLALSTQYMILNYSTGASQDLFPYDCEERKPIVKRIGREEFLLAAPGGLGMFANAEGISQRAPVSWSENVIAAAVCFPYVVALDEGFVTVHSMLDQQLKQTLSFRDGQ-------LLQDFEGKVVVASSKAVYMLVPLPLERQIQDLLASHRVEEALTLTEAAQRNIPK-------EKYQILHRRILQQAG-------------------FIQFGQLQFLEAKEHFRKGQ-------------------LDVRELISLYPLLLPASSSFTRCHPPLHEFADLNHLTQGDQEKVQRFKR------FLISYLHEVRSSDIANGFHEDVDTALLKLYAETSHESLLDLLASENACLLADSAPWLEKHHKYYALGLLYHYNGQDAAALQMWVKIVNGDLQDSTRP--------DLFEYVVDFLSFCSN--LDLVWRHADWALQKDQKIGVQIFTKRPTSEERRGQ-LNADDVITYLQKHSQAL-LLYLEHLVLEKKLQKEKYHTHLAVLYAEKVLGLISRPSTSEEQLSAARQKLQRLLKES-NLYRVQLLLGKIQDSELLLLERATLHGKLEEHDKALHVLVHQLKDSSAAEEYCSWASASQDSSYRQNLFHQLLSVYLDPDVPGGAQTVAAVDLLNRHAEVFDAVRVLKLLPEDWSLPLLRPFLCGAMRATVHARCTSQVALGLARAQNLQLLHDRLKYRGGPVLVSEKKGCQLCHNTFS------EPDCACLPGGTPVHINCVAKKALDLPHENAHHSNHT--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q07468-1", "uniprot_id": "VAM6_YEAST", "id": "Q07468-1", "name": "Vacuolar morphogenesis protein 6", "aln": "MLRAQKLHSLKSSDITAILPTEQSQKLVLAKKNGDVEVYSRDGNTLKLFQVYPDLLQNAKNDPLPPVIENFYFANELSTIFAQCKETLILLSTTNLHEYDRIIDRRGINHCWLFERSHKNKEEKNTYLIYSTINTAKMRVLIWEGRTYKNMMEASLSYRKETIRSIYPGETGITLATDLGIYHWPYNKPSLIRIEKTVKNKFPKDMISALTELKEQAEKVIEKKPKKNSHFDAQSFSSMDRMSRKSSMSSLWYRTIRNERGNKIRYTFELDGNDATPMIIDGATKKIFKVELMHNNEEPFLIATDHATFSESNSEFDHMQYLSSNLLMLYNSSTIKFVDYENGFTFLQQKIPEGIKWVKNLSGTYFLVWTSNDEVQLFSYHVDDGSEDDDQESICGDINDPDFYQLWRKVLFYKFFIDSPHSKELCVSDNPEESLDICAMKLRDLTVMWCLRIFDKFQNYMVQLERSRNSRMIRSKCEEMIIKSIFDLFIKFWAPPQLVILKVFPSAISSLVLEITGQEHHCLLKEAEEVKETYDIPPHLLNR-WCLPYLTDTRRHLQNLLSKENDDESRITWCYRDREIKQSFDFFLISNHDDVDLNTMLTLIDTVLFKCYLYYNPPMVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNKLHTVLIKLYLENLDIPSTRIKLKSLLETTSVYEPRTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTKGEELLLYLYSKLVSIYD--SNRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNCGKVLQERFNAKNEKSSRIKQKTLGEVINELNNK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: * :. :. .. : :. : . :. *.*::.. ::: : : : : : : : .* . * : :..*::. : : * . :.:* : :::.* ... * .: : * .: : :: : . . *. : : :*: :: .:: * :. .. :.: ... * :: . :: . : :* *. :. * : *: : . :* : *::. . : * : : . : ::* .. . **:* : *::. :*:* :: :. . **:* * : * .. :*:* .: * ** .:. . :. :* :.*:.:: * : :* . :. * :**.*:* * . : :: ** * .. *: :: : * :*: . :. *::: ..:*: :*.* .: :: :*. : :::: ::** *:: :. ::::. :.: . : .: ::*. : * : ***. : :*: :: ** * ** *:: . : : : : :*: : . : : .** :*.:*:*:*:.:: * ** .** . .. .: *:: : . . : :::*: *. :: ..: : **: *: : .: :: :: .* : : : :. : .. :*: . * :*:: : . . . .* :* . ", "identical_positions": 99, "similar_positions": 297, "identity": "9.41%" }, { "cls_id": "homologset.agr.HGNC:16837", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZAS0-1", "uniprot_id": "D3ZAS0_RAT", "id": "D3ZAS0-1", "name": "", "aln": "MSGGGRTSEAFLWDLLIIGHTQSLTMNSVAAALLVWILTSPSSSDHGREKGWPTHMACSSGGLEVVYQSCDPFQDFGLSIDQCSKQIQPNLNIRFGIILREDIRKLFLDIAFVAKGSSLLNYSYPLCEEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENHATVACANATVTCS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88188-1", "uniprot_id": "LY86_MOUSE", "id": "O88188-1", "name": "Lymphocyte antigen 86", "aln": "-------------------------MNGVAAALLVWILTSPSSSDHGSENGWPKHTACNSGGLEVVYQSCDPLQDFGLSIDQCSKQIQSNLNIRFGIILRQDIRKLFLDITLMAKGSSILNYSYPLCEEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENRATVACANATVTSS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95711-1", "uniprot_id": "LY86_HUMAN", "id": "O95711-1", "name": "Lymphocyte antigen 86", "aln": "-------------------------MKGFTATLFLWTLIFPSCSGGGGGKAWPTHVVCSDSGLEVLYQSCDPLQDFGFSVEKCSKQLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPICEAALPKFSFCGRRKGEQIYYAGPVNNPEFTIPQGEYQVLLELYTEKRSTVACANATIMCS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:..:*:*::* * **.*. * :.**.* .*...****:******:****:*:::****::.*:*********:**::****::::::***:**:***:** *********************** : :******:*****.*:::********: .*", "identical_positions": 102, "similar_positions": 47, "identity": "54.55%" }, { "cls_id": "homologset.agr.HGNC:16838", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9Q8M1-1", "uniprot_id": "E9Q8M1_MOUSE", "id": "E9Q8M1-1", "name": "", "aln": "----------------------------------------------------------------------------------------MRRSVLVRNPGHKNLRPLYGDLHSDPEDLDSSPKDPDPISESP--EPEPEDLNTVSEDGDASLEDLDPEADEAPRSILGKPDLDSQDLDPMSSSFDLDPDPDVIGPVPLVLDPSNDTPSPAAPDVDSLPSGLTATPEILATS-PAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRT-----------HTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAAAAAGLG-------LGSGLSPVSMMRPGQISFLGPDAVSVLESGLGLSSG--------ASSARSSAPTSVLGSLQNPILQTHSG--SISSPDLVLSSDPKPGHVADPDVVPSPDQESDPSPNPDLVPSPDPKPKSQTDPCSPTHDSSSP-----ALPTGESPKWVKEEGALLGPDG---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZRG3-1", "uniprot_id": "D3ZRG3_RAT", "id": "D3ZRG3-1", "name": "", "aln": "MAPAAEGAGELQVPAAPAAALGRPLSLLGSAWRGRWAEGAASGAGERWGFLQAWGGETPAGQPECSQAGQGRGASDPVPESARGSTSRMRRSVLVRNPGHKSLRPLYGDLPSDPEDLDPSPKAPDRISESP--EPEPEDLNTVSEDGDASLEDPEPEAEEAPPSMLGKPDLDSRDLDPTSSSFDLDP--DVIGPVPLVLDPSDDTLSPAAPHVDSLPSSLTATPEILATSSAVVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQS---------------------------------------SNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEG------AAAAAAAAAAAAAGLG-------LGPGLSPVSMMRPGQISFLGPDAVSVLGSGLGLSSG--------ASPARSSAPTSVLGSLQNPLLQTHSG--SVSSPDLVLSSDPKPGLDADPDVVPSPDQELDPNPNPDLVPNPDSRPKSQTDPYSPTHDSPSP-----ALPAGESPKWVKEEGALLGPDG---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NW07-1", "uniprot_id": "ZN358_HUMAN", "id": "Q9NW07-1", "name": "Zinc finger protein 358", "aln": "----------------------------------------------------------------------------------------MRRSVLVRNPGHKGLRPVYEELDSDSEDLDPNPEDLDPVSEDP--EPDPEDLNTVPEDVDPSYEDLEPVSEDLDPDAEA-PGSEPQDPDPMSSSFDLDP--DVIGPVPLILDPNSDTLSPGDPKVDPISSGLTATPQVLATS-PAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRT-----------HTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEG--AAAAAAAAAAAAAAAAAGLG-------LGPGLSPASMMRPGQVSLLGPDAVSVLGSGLGLSPG--------TSSGRNPDPGSGPGTLPDPSSKPLPGSRSTPSPTPVESSDPKAGHDAGPDLVPSPDLDPVPSPDPDPVPSPDPNPVSCPDPCSPTRGTVSP-----ALPTGESPEWVQEQGALLGPDG---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A9Z8-1", "uniprot_id": "A0AB13A9Z8_DANRE", "id": "A0AB13A9Z8-1", "name": "", "aln": "-----------------------------------------------------------------------------------------MAFIKVESEDMMIEETFTVKHEETEEAFRVKHEDPEEQTDLVGLKEEEEELNDMEGK-EQCVKHQDFVNVEQFIKIEPTSSGKTDQKNKPNQLFICQQCGRAFSRKYKLKNHMTIHTGEKPFTCEQCGKSFNYKENLNYHM------RVHTGERPFSCKECGKSFVHKAALKYHTRVHTGEKPFTCELCGKSYVHKGNLNYHKRGHTGERPFTCEQCGKSFVQKHKLNNHILSHTGEKPFKCLQCGTGFSCKANLHTHMKVHSGEKPFTCQQCGKSYTKKSNLKKHMNVHTGENLFRCERCGQSFRYKHSLDSHIQKRELSGGNCLIKYTAEKPYACQLCDKSYKNKTHFDSHMKIHAGEKPFPCDQCGGSFSNKAALGSHMKVHIVRVTQREENPELSEIQENDESENHDDIEDVDNSIRTETTSSDKTLEKAESNRDLTCELCGRSFSQIYKLKNHMIIHTGEKPFACERCGKSFFYKGNLISHIRVHTGEKPYTCKQCGKSFNYKGNLNSHIRIHTGEKPFTCTQCGRGFSFHGNLNYHMRVHTEEKAFSCKECGKSFNYKANLNSHMRVHSEKKPFTCEVCEKSFAKKSYLKAHIKLHSSESVQM", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *.. . ... . . * : . : : :: : : *:** : . : . :. : : . .. .. : : .. * : .:. : : . : ..:. . :: : ***** :**::* :.:.*. * *.*:****: * ****: * ..* *: *** **: * ***:* : .* :* **:****.:* **..*. : * *::.*.* :*..* *.*.: : * * **:..****. : * :**::* . :::: *::**:**:*:.* :*. :*.:.:** .*::** . . * : : * .. :::: *. : :::: : * . * .:* :: : * ...: .* .: . ..... . . *. : : . .. . .:: * :: . .. . . . . : :. .:. .* . : . .::: . * ..:. ", "identical_positions": 98, "similar_positions": 194, "identity": "14.04%" }, { "cls_id": "homologset.agr.HGNC:16839", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91YX0-1", "uniprot_id": "THMS2_MOUSE", "id": "Q91YX0-1", "name": "Protein THEMIS2", "aln": "-MEPVPLQDFVSGLDPTSLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHVQLQKVVCEYPETGQTLELNPNFTGLFSPLTSLRSYRTLEDLVSAMPQNSTRWP-IYFKSTQRIVTKASVVPEDQPLRLEAVEIHHG-IRYARCVQVSK-TKEL-LHLPLSQKGPFWRCKPSAPQTLHQILQDPALKDLTLSCPSLPWNS--VILKPQYMLQAIMHMRSSIVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAG-GGPFPLTTEILEVPEGPPVFLSPWVSFLRKGQRLCIYGPASPSWRVVASSKSRKVPRYFMLSGAYQGKLKRRPREFSTAYDLLGALQPGRPLRVVATKDCDGNEEENPDFSFLAVGDRLEVLRSGQVCGTK---GQDIDVLVCQRLSEQSGEEEEDLEEIEDEAEDKEQILLPLYLSGSFVEEVNDSRRYNLVDLTAQYSLPCEVKVVTKDTRHPTDPLASFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEAEGQPAQVARP-LSIAPVEELSEAFYYSLRKLPASESQAPPPRPPKSQGINKKQQNIQSCKESSVKP-QVVEPQKSCPQPQLKAKTLEALPKNKSNVYSKISVHKKDRKPNPQTQNSVLSMKPKTSSSLGKHSTMESHLLPDPDMDDHDYEEI-----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZDR7-1", "uniprot_id": "D3ZDR7_RAT", "id": "D3ZDR7-1", "name": "", "aln": "-MEPVPLQDFASSLDPASLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHIHLEKVVCEDPETGQTLELNPNFTGLFSTLTSLQSYRTLEDLVSAMPQNSTQCP-IYFKSTQRIVTEARVVPEDQPLRLEAVEVHHG-TRYARCVQASK-TQEIILHLPLSQKGPFWRCKPSAPQTLLQILQDPAMKGLRLTCPSLPWAS--VILKPQYQLQAIMHMRSSVVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAR-GGPFPLSTEILEVPDGPPIFLSPWMSFLRKGQRLCIYGPASSPWRVVASSKSRKVPRYFLLSGAYQGKLKRRPREFPTAYDLLGALQPGRPLRVVATKDCDGNEEENPEFSFLAVGDRLEVLRSGQVCGAQ---GQDIDVLICQRLNEQSGEEEEEEEEEGEEVEDKEQVLLPLYLSGSFVEEVNDSRRYSLADLTAQYTLPCEVKVVAKDSHHPTDPLTSFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEIEGRPGQVAGP-LSVPTVEELSEAFYYGLRKLPVSGNQAPPPRPPK------KQQNTQRCKEGGVKA-RVVEPKPSCPQLERKAKTLEAFPANKSSVYSKIS-NKKDHKSNPQAQNSVLSMKPKSSSSLGKYSTTESHLPPDPDIDDHDYEEI-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5TEJ8-1", "uniprot_id": "THMS2_HUMAN", "id": "Q5TEJ8-1", "name": "Protein THEMIS2", "aln": "-MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCLSTGDLIKVTQVRLQKVVCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQSSKQLP-TCFMSTHRIVTEGRVVTEDQLLMLEAVVMHLG-IRSARCVLGME-GQQVILHLPLSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHS--LILRPQYEIQAIMHMRRTIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAW-EGPFPLSMEILEVPEGRPIFLSPWVGSLQKGQRLCVYGLASPPWRVLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTAYDLLGAFQPGRPLRVVATKDCEGEREENPEFTSLAVGDRLEVLGPGQAHGAQ---GSDVDVLVCQRLSDQAGEDEE--EECKEEAESPERVLLPFHFPGSFVEEMSDSRRYSLADLTAQFSLPCEVKVVAKDTSHPTDPLTSFLGLRLEEKITEPFLVVSLDSEPGMCFEIPPRWLDLTVVKAKGQPDLPEGS-LPIATVEELTDTFYYRLRKLPACEIQAPPPRPPKNQG---LSKQRRHSSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKDGSSTYSKIPAHRKGHRP----------AKPQRQ---------------DLDDDEHDYEEILEQFQKTI---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6D4-1", "uniprot_id": "A0ACD6B6D4_DANRE", "id": "A0ACD6B6D4-1", "name": "", "aln": "MGDLQSLQAFINCLDQRSLPRILQVCSGVYFQGSVYEISGSEVCLSTGDLVKIIGLELLSVSCEDVNTGDSFVLPIHYTGNFRLVAEDLPYNTVEELVGLCPVGVDACGSFTFRSTQELIVDNFTLAPDEHLTLLSVEVSEDGERLARCQVLGHNMAYAELLLPLSLKGEFYECEDERGYFLQEIMSSARLSCRRFCNTNTKSSGGLLMFSPVYEISAIMHLRKNIVKFPSTLEVDVQDVTDQFQDLVFITPLSLPEVVSQPKESFPTMAEILEAPEGNQYFSCSWFGGLQKGKSLILHECHQKTMILASTPKGKKGKQYFMISDDYGGRMRRRAREFGSVYELYLASSQSPGLKVSVSRDYEADEDEG--MPALGVGENLEVLGMSLMDRLKPGAAEKVESLICKRTHEVDDDDDD-------DEDDSEEISMPLFMAGHFVEKLSDNKKYRLNDLVSG-SLPVDVKVVTRDKDLEKDPLMGLPALKLEETFTETTVLTSLPHNPDWCFELPVRWLQMSVCFTSDDLPWSRPPELHVETVTEMTEKFYYEYHKLIGKTEEPPPRPPKRKKSSCDANKKVQSLPSLGSSVSKQLDKLSLGPKVEKRSVPPPPQDEQTLHQPPPLLPRKSISLAESSSMPNMYVKSPRMSHKSGTFTDYIQILVVLNKMYTLTFSYLPLIKQRRDFLTRIMTTSLSRTHL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .** * ** ****:*:*******:**:**: *.* *******:*: :.* .* ** :*.::: * :: * * : .*.*:*:**. . . * **:.::.. .:. *: * * :* : . * *** . * **** ** *: : . * :::... :. : .. . ::: * * :.****:* .:**:******:*:*** . :.: *:.** *.**:: .** ****.*:* * ..*.. *:**: * :: . . : ::.*.:* ::*::*. * *:::**.*** :.*:* * . . *:* .::* :.:.:*. :. *.**:.**** . : ...:: *:*:* : .:::: : :. *.: :*:.:.* ***::.*.::* * **.: :** :****::*. .*** .: .*:***.:**. ::.** :* ***:* ***:::* .. . * : .* *::: *** :** :.** * : .:: : . . . : : : :: . : . : .:. . .*: . . :. : ", "identical_positions": 181, "similar_positions": 218, "identity": "25.89%" }, { "cls_id": "homologset.agr.HGNC:16840", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIE9-1", "uniprot_id": "MED20_RAT", "id": "Q5XIE9-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGVTCVSQMPVAEGKSVQQTVELLTKKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQAGKLMYVMHNSEYPLSCFALFENGP----CLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGT-VTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHT-PGAPTVFG--------------NRHDAVYGPAD---TMVQYMELFNKVRK--------------QQQVP-------VAGIR--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0X0-1", "uniprot_id": "MED20_MOUSE", "id": "Q9R0X0-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGVTCVSQMPVAEGKSLQQTVELLTKKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQAGKLMYVMHNSEYPLSCFALFENGP----CLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGT-VTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHA-PGAPTVFG--------------NRHDAVYGPAD---TMIQYMELFNKIRK--------------QQQVP-------VAGIR--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H944-1", "uniprot_id": "MED20_HUMAN", "id": "Q9H944-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTGKLMYVMHNSEYPLSCFALFENGP----CLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGT-VTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHT-PGAPAVFG--------------NRHDAVYGPAD---TMVQYMELFNKIRK--------------QQQVP-------VAGIR--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DBX1-1", "uniprot_id": "MED20_DANRE", "id": "Q6DBX1-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGVTCVCQVPVAEGKSVQQTVDLLHRKLEQLGAVKQGNFWVDCETYHATGN---ATGQPSKLLYVMHNSEAPLSCMALFEGGP----GLSADANFDVLMIKLKSHFQNAKGHKVESRGTRYRYCDFLVKIGT-VAMSSSARGISVEVEYCACVIPGDCWNLMKEFMQSFLGSNT-PELPTVFT--------------NKAEGLYVPVDCMDTMSQYLELFSKVRK--------------QQVLP-------GSGVR--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P91641-1", "uniprot_id": "MED20_DROME", "id": "P91641-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGVTILQPYPLPEGKSGAHIIDQLSKRLLALGATHAGQFLVDCETFISTPQP--HNGAPGRAVHVLHNSEYPASTFSIIDNGTGKQVAIVADNIFDLLMLKMTNTFTSKKQTKIESRGARFEYGDFVIKLGS-VTMMEHFKGILIEIEYKSCVILAYCWEMIREMLQGFLGIAVNKDFPSYFAPQTIMTAMGQQQLHAKHNDIFEPMD---TVKQYLEQFTNYRKHVTLMGGMGSGPGSQQVGPNVHMSPAVAGLHRS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34162-1", "uniprot_id": "MED20_YEAST", "id": "P34162-1", "name": "Mediator of RNA polymerase II transcription subunit 20", "aln": "MGKSAVIFVERATPATLTELKDALSNSILSVRDP----WSIDFRTYRCSIKN--LPADVSKLMYSITFHHHGRQTVLIKDNSAMVTTAAAADIPPALVFNGSSTGVPESIDTILSSKLSNIWMQRQLIKGDAGETLILDGLTVRLVNLFSSTGFKGLLIELQADEAGEFETKIA--GIEGHLAEIR----------AKEYKTSSDSLG-PDTSNEICDLAYQYVR--------------------------ALEL---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** : : . : . : * . : : : :* .*: : . . .: :: : . . . : :... ** ::: . . . :.:: :. ::* .: :: : : : . . . .: : * . : . . . . * : : : : : ", "identical_positions": 10, "similar_positions": 67, "identity": "3.88%" }, { "cls_id": "homologset.agr.HGNC:16841", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q2PE16-1", "uniprot_id": "Q2PE16_DROME", "id": "Q2PE16-1", "name": "LITAF domain-containing protein", "aln": "MDQKRAMLYPQVDFNAPTAPSPTPTRELGNPIANGLP---------------IEAPPSYDVAVSVPVAPAVSAPAIAPARPPPVVVVEQPAPQPPTVVPTDTLHLGPNRSRVLCPACGANKTTRMTHTANSRTHMVAGLLCLVGFCCCACFVPYCMNSCRTGNHYCRKCNTFLGAYNPKGMNR--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8MME9-1", "uniprot_id": "Q8MME9_DROME", "id": "Q8MME9-1", "name": "LITAF domain-containing protein", "aln": "------MQYNQQPAGAPGYPHQMP-------------------------------PPSYEQVVHVQAPVRVVHHTTAP---PPVVIIQHQAVLP----------VGPDPTFITCPHCHVQKLTRVEYSPSVKTHCMAAILCIVGLWCCAC-LPYCATSCMNANHFCGNCNKFVGVYNSD------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W217-1", "uniprot_id": "Q9W217_DROME", "id": "Q9W217-1", "name": "LITAF domain-containing protein", "aln": "----MDSVYPAAPLEAPKGSVELQAT----PEQQHLL---------------PPAPPSYDQATTTPAETTGPAPVPASTSTTQHTVVVVPGSPY-----------GPEPMDVQCPYCHNYARTRVSFKPNSRTHLIALILCLFQLYCCVC-LPYCISSCMNTNHYCGMCDRYLGTYDRK------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W221-1", "uniprot_id": "Q9W221_DROME", "id": "Q9W221-1", "name": "LITAF domain-containing protein", "aln": "MDSKQPPPYSEQSGYTPAQTYQPGGP---------------------------TQPPLYPPMPQPPQSSTVIIQTTTTSNLVPIGS---------------------GPTRIRCPSCHAEVLTTVKSTPSGRTHCWALILCLFICWPCVC-LPYCMDSCQNANHYCPNCSAYIGTYEN-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4K8A8-1", "uniprot_id": "A0A0B4K8A8_DROME", "id": "A0A0B4K8A8-1", "name": "LITAF domain-containing protein", "aln": "MEKN--FQYENMQPQAPGFQAPPSYD---------------------------SAP--QQVYPQLHQGQGVILQGENTENYESIGNNAPPNVLG------------QCPSVATCPSCGVRRETKVEFEPSTKTHLLALLICMLGGICCCC-IPYCTDSCQSAKHTCTSCGAYVGTYKN-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P0C0T0-1", "uniprot_id": "LITAF_RAT", "id": "P0C0T0-1", "name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "aln": "MSAPGPYQAAAGPSVMP--TAPPTYEETVGVNSYYPT---PPAPQPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPISFYD-------------RPIQMCCPSCNKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JLJ0-1", "uniprot_id": "LITAF_MOUSE", "id": "Q9JLJ0-1", "name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "aln": "MSAPGPYQAAAGPSVVP--TAPPTYEETVGVNSYYPT---PPAPMPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYD-------------RPVQMCCPSCSKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99732-1", "uniprot_id": "LITAF_HUMAN", "id": "Q99732-1", "name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor", "aln": "MSVPGPYQAATGPSSAP--SAPPSYEETVAVNSYYPT---PPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLD-------------RPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6GMG8-1", "uniprot_id": "LITAF_DANRE", "id": "Q6GMG8-1", "name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "aln": "MAMPMPTAPPMENTTLVGHPPPPSYDEISGANPYYPAGPYPPADMKASGPPPYPTQEYNQMYPPTAQGQPVTSP---VVAVQTVYVQPGLVFGN-------------VPVQAHCPVCSQSVITRLEYSSGPLVWLSCAGLAVFGCIYGCCLIPFCIEDLKDVTHHCPNCSSVLGVHKRF------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W1P0-1", "uniprot_id": "Q9W1P0_DROME", "id": "Q9W1P0-1", "name": "LITAF domain-containing protein", "aln": "--MS-------SFARVP-STPPPSYEEAMG------------------------------------------------WETRRSHSTTWLLAEN-------------TSSLMICPMCHDEIETTTKIRRRWIAYVASGIVLFTTCGIGCWLIPCILDCFNEIHHSCPVCKATLGIVPQQDQRWPT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IRE5-1", "uniprot_id": "Q8IRE5_DROME", "id": "Q8IRE5-1", "name": "LITAF domain-containing protein", "aln": "--MSKPGSAPPQFTYVPPPSAPPSYQEAVGG---------------------------------VKPVGPYTPVVAPATTANTTIVTTVVPISR-------------TSTHMICPSCHAEIETTTRTEPGMIAYLSGFLIALFGCWLGCCLIPCCIDDCMDVHHSCPNCRAYLGRYRR-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * : . : . :* * * * :* ", "identical_positions": 8, "similar_positions": 6, "identity": "4.32%" }, { "cls_id": "homologset.agr.HGNC:16842", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B3DMA0-1", "uniprot_id": "P5I11_RAT", "id": "B3DMA0-1", "name": "Tumor protein p53-inducible protein 11", "aln": "MAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRVWQFLSAMLFSSVAIMALALPDQLYDAVFDGAEVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQSLVVTATLAETGLMSLGTLLLLASRLLFVIVSIYYYYQVGRKPKKV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q4QQM4-1", "uniprot_id": "P5I11_MOUSE", "id": "Q4QQM4-1", "name": "Tumor protein p53-inducible protein 11", "aln": "MAGKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRVWQFLSAMLFSSVAIMALALPDQLYDAVFDGAEVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQSLVVTATLAETGLMSLGTVLLLASRLLFVIVSIYYYYQVGRKPKKV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14683-1", "uniprot_id": "P5I11_HUMAN", "id": "O14683-1", "name": "Tumor protein p53-inducible protein 11", "aln": "MAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYDAVFDGAQVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQFLVVTATLAETGLMSLGILLLLVSRLLFVVISIYYYYQVGRRPKKA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PA32-1", "uniprot_id": "A0A8M9PA32_DANRE", "id": "A0A8M9PA32-1", "name": "Tumor protein p53-inducible protein 11", "aln": "MATKPHPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQMLGNEIKFAVREPVGLRLWILFSAVVFTVMALMALAFPNQLYEVVFDQEQTVTSVSIRLYGGAILSLSLIMWNGLYTAEKVIIQWTLLSEACYFAIQFLVTSVTLVELGSLPNAAILLLLSRIFFLTVTLSYYYHLGRRPKKI", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * ****************************************:*******::***:***:* :.**::*: :*:****:*:***:.*** :..:...*******:**:******.*********:****:*****.:* **.:.**.* * :. . :*** **::*: ::: ***::**:*** ", "identical_positions": 126, "similar_positions": 47, "identity": "66.67%" }, { "cls_id": "homologset.agr.HGNC:16843", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LVM9-1", "uniprot_id": "F1LVM9_RAT", "id": "F1LVM9-1", "name": "", "aln": "MWLMAKDTGMSVASVTLASALQVRGEALSEEEIWSLLSLAAERLLEDLRNDSS--DYVVCPWSLLLSAAGSLSFQDNVSHIEAAPFKAPELLQGPDEEERPDASQTHVYSLGMTLYWSAGFRVPPKQPLQLQEPMHSLLLAMCEDQPRRRRPLQAVLEACRIHQEEVAVYPAPASLHISRLVGLVLGTISEVERRVAEENACEQRNRSCFLRSRLHQADSESPGSRAPDALQPRRVSGRSTETQSSLERCWSTTAHSRSGFN-STFAGAGPCDCEEGPRCGSGPMLLAEAESSKPATSSPRNFLHRKGKFSRPEFILLAAEAPVTLHLPGSIVTKKGKSYLALRDLRVLLLNGQCLEVKCDVESTAGAVFNAVMSFANLGETTYFGLAYVKGEEFFFLEPNTRLCKVAPEGWREQQPKSSVDTLTLFLRIKFFVSHYGLLRHSLTRHQFYLQLRKDILEERLYCNDETLLQLGVLALQAEFGSYPKEQVEGETYFQIQDYIPARLIERMTAIRVQVEVSEMHRLSPAPQGEDAELEFLEVVQQLPEYGVLVHRVSPAKKRQEGGMALGICTKGIIVYEVKGSRRTTTFQFPWRETGMISTHRRKLTVTSSTTGKKYTFVTDSAKTCKYLLGLCSSQHWFNAHMGLEQPPHLLTGQDKFAQIASLNSAHQTQANPLTWIQKLSCSENELCVPRLQNATGGQLGTAMENMQGSKEPEMGRNRSSPYTGGEQLHSIGLNQRPTHTLFGTAGHSTCAGS------------------QKSKRKGFMDEPNGDIMCVMLKRDPLLGFGFVIYEGEDKEQSKTGIFISSLIPGGPAERAKKIKPGGKILALNHISMEGFTFNMAVKMIQNSPDDIELIISQPKGVCG-------DIPSEDKNSTASSGTFCTDILSNRCRGQQSAHTQDQDRNARGPETVQQGAGSCPPSPLDA--GEIYFVELVKEDGTLGFSVTGGINTSVPHGGIYVKSIIPGGPAAKEGQILQGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVAQLVLERRGPRAAPQCP---------------SADDRMGEVHMAVSLVTAKPGRPASRVSVTDGPKFEVKLKKNSSGLGFSFVQMERGNHIHVKSDLVRIKRLFPGQPAEEHGAIAAGDIILAVNGKPIEGLAFQEVLHLLRGAPEEVTLLLCRPPPGILPEMEQGWQTPELSGDQRLTMATRAESEQSPSLDQEDNWRDSTSLDAGDGLSPRPESSYKAEKEVKGDGDKQRPWARSLMHPMESHPHLCKLHPEPETPALATSLEKDMRQNCYSVCDIRRLG------------------SSSLTLDSEGYMALTSTSAGQLPCEECLEADSETIPLPRFCSSGALLKSSLPEGSPGSESDWEDLDEPVDGDEVLRWTHSARVS-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A140LI67-1", "uniprot_id": "FRPD2_MOUSE", "id": "A0A140LI67-1", "name": "FERM and PDZ domain-containing protein 2", "aln": "MRPLAKDTGMSVASVTLASALQVRGEALSEEEIWSLLSLAAERLLEDLRNDSS--DYVVCPWSLLLSAAGGLSFQDHVSHIEAAPFKAPELLQGSNEEGQPDASQMHVYSLGMTLYWSAGFRVPPNQPLQLQEPVHSLLLAMCEDQPRRRQPLQAVLEACRIHQEEVAVYPAPASLHISRLVGLVLGTISEVERRVVEENACEQRNRSCSLRSRLHQADGESPGAPASDALQPRRVSERSAETQSSLERC---TAHSRNSFVNSTFAGAGPCDCEESPWYGSEPMLLAEAESSQPATSSPRNFLQRKGKFSRPEFILLAGEAPVTLHLPGSIVTKKGKSYLALRDLCVVLLNGRCLEVKCDMESTAGAVFNAVMSFANLEETTYFGLAYVEGEEFFFLDKDTRLCKVAPEGWREQHPKGSVDTFTLFLRIRFFVGHYRLLRHSLTRHQFYLQLRKDILEERLYCNDETLLQLGVLALQAEFGSYPKEQVEGKAYFRIQDYIPARLIERMTAIRVQVEVSEMHRLSSAPWGEDAELEFLEIVQQLPEYGVLVHRVSPEKKRPEGKMALGVCTKGIIVYEVRGSRRIATSQFPWRETGMISTHRKKLTITSSTTGKKYTFVTNSSKTCKYLLGLCSSQHWFNAQTGSKHPSHRFTGQDKFAQIASLSSAHQTQANPITWIQKLSCSENELCVPRLQDATGGQLGTSMENKQGFKEPGKERIGSSPYTGGEQLHSIGLNQKPAQTVFGTAGHSMCAGSNCLGRRTQICCFDSVSGSQNSKRKGLFGEPNQDIVCVMLKRDPVHGFGFVINEGEDAEQTRSGIFISSLIPGGPAERAKKIKPGGKILALNHISLEGFTFSMAVRMIQNSPDDMELIISQPKGVCG-------TIHSEEKNSTASSGMFCTDILSNRCQGRQSPHIHDQDRSVRG-TEMAQGAGSCPPSPLQTNTGEIYFVELVKEDGTLGFSVTGGINTSVPHGGIYVKSIIPGGPAAKEGQILQGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVARLVLERRGPRAAPQCP---------------SADDRMGDVHMAVSLVTARPGRPASSVSVTDGPKFEVKLKKNSRGLGFSFVQMERGNCIHTKSDLVRIKRLFPGQPAEEHGAIAAGDIILAVNGKPIEGLAFQEVLHLLRGAPEEVTLLLCRPPPGILPEMEPGWQTPELSGDQRLTMATCAGSEQSPSLDQEDNWRDSTSLDAGEGLSPGPESSYKDVRQVKGDREKERPWAKSWMHPMESHPHVCKLHPEPETPALATSLEKDMRQNCYSVCDIRRLGSLELDRDGADGATCFLPESSSLTVDYEEYLTLTSASAGQLPCEECLEADSETIPLPQFCSLGALLKSSLPEESQGSESDWEDLDEPVDRDEVLRWTRSARQPLAAEP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6IN97-1", "uniprot_id": "FRP2L_HUMAN", "id": "Q6IN97-1", "name": "Putative protein FRMPD2-like", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSIPFP---------------------GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCP---------------SANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLG------------------RYSFSS------PLTRLSTDIF-------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GWI9-1", "uniprot_id": "A0AC58GWI9_DANRE", "id": "A0AC58GWI9-1", "name": "", "aln": "----------MSTFVTLAEVLESRAAPLEEDEVWALLLGATEALIDISSKDDGNMCCVISPGSMLLSAVGSIAFKTCSRSEDVGSFTCPEMSQSNTSSRRLASEKMVVYSLGMTLYWAVDYNLPQNQPVQVSDTLNSLLLSMCEDVAHRRVNLLTVLETAENHHQTAVLPRP-------------------------------EKTIRQMAEDVLQTEKPSNDSAHLIDRSQMVRERLRGASSQNSVWTQKGNSTPSAADFSRFHSSHQRSRNSTYMSQSPVLDRRRQFALRPDQLFASSFSLNERKMKDTGPEFIRMLEEPLVVLELPNSIVSNKGKSSSNQRDLTVLMPNGQNVLLKCDVKCRGRDAFDMIVAHTNLVEHFYFGLAYSYDNEFFFLDNDTKISKVAPG----VWKKVPTATFVLHFRIKYFVSDVSLLLNKFTRHQFYLQLRRDLLDDRLQCNEETCLFLGALALQAEFG-DSLPEVYGKNYYQPEHYVSKSVVQKMAMPCLKEELLRLHVNNANMSAEEAELEFLKSVQQLPEYGVLFHRVAREKKPVFGELLLGVCAKCITVYEVINNCRTASLTFHWRDTSSITSTRRKFIIECSTSKKKHVFLTEKSKVAKYLCDLCSAQHKFHKEMSSRQLTHSLASEESIVQYAALCRAQNNEVNDSSADESMSKLCEDIATR---IEAKIKLQRDLLDNPGSQSPVLQRSLCSTPKRGSDVPSVSSPLRDTPTGARTP--------------------------------------EREIICVSLKKDPKVGLGIVIVGEDTAGKLDLGIFIASVVPGSPADRDGRIKPGGRLISLNQLSLEGMSFSEAADIMQSSSNDVELIISQPKAQCKRGGSVSLNERSYESQSTILADGRTGDEFLDELVSVMMTPKASNRLHVPEVRIINAQDDYSRSASLISLRPEEFTVTLMKSGGSLGISIAGGVNTGLRYGGIYIKSLVSGGVAEQDGRIQTGDRLLEVDGIRLQGFTDQQAAECLARTGEVVGLVLERDGGSMLQRGPGSPQLRNTLSICTPGPAGTQARKSCPAITMTRPFNIKPRDYSFVSDDNIQEVTLKKRLNGLGFSFFISELN-TSRDRGSIVRIKTLFPGQPAEESGRIQEGDVILSINGEPLKGLSYQHVLQLLRNSPSEVRMLLCRPAQGTLPAVSEKIGQLTCS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.: . *****:***: * *:*.:**.:** .*:*. ***** : * .*. . *:::. . :* . *:*. **.***. ******. * : :..:**** ********* * * **:**::**.. :** :*.**:***.:*.** :*****. * ** :. * ", "identical_positions": 82, "similar_positions": 50, "identity": "5.77%" }, { "cls_id": "homologset.agr.HGNC:16844", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q02930-1", "uniprot_id": "CREB5_HUMAN", "id": "Q02930-1", "name": "Cyclic AMP-responsive element-binding protein 5", "aln": "MIYEESKMNLEQERPFVCSAPGCSQR-FPTEDHLMIHR---HKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAMPSPQSSSVITQ--------APSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHP-------------HQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAH-HQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVD-----------------------------EDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEV--------SMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL-----------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8K1L0-1", "uniprot_id": "CREB5_MOUSE", "id": "Q8K1L0-1", "name": "Cyclic AMP-responsive element-binding protein 5", "aln": "------------------------------------------------------------------------------------------------------MSMR-------------------------------------------------------------PVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMSTIGHMMEMMGSRQDQTPHHHLHSHP-------------HQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAH-HQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVD-----------------------------EDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEV--------SMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL-----------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LPZ0-1", "uniprot_id": "A0ABK0LPZ0_RAT", "id": "A0ABK0LPZ0-1", "name": "Cyclic AMP-responsive element-binding protein 5", "aln": "MIYEESKMNLEQERPFVCSAPGCSQR-FPTEDHLMIHR---HKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSELDCSFEHEFRKAQEEESSKRNISMHNTVGGTMTGPGAHQLGSSRMPNHDTSVVIQQAMPSPQSSSVITQ--------APSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGNMSTIGHMMEMMGSRQDQTPHHHMHSHP-------------HQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAH-HQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVD-----------------------------EDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEV--------SMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTSHRTDLNPIL-----------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ACD6B5W2-1", "uniprot_id": "A0ACD6B5W2_DANRE", "id": "A0ACD6B5W2-1", "name": "", "aln": "-------MNSEQERPYVCSAPGCSQR-FPTEDHLMIHR---HKHEMTLKFPSIKNDNMLSDQTPTPTRFLKNCEEVGLFSELDCSIEQEFCKAQEEEDSKQNITLHG-----QGGPNQHQQAHSRMTNHDS-IVIQQALPSPQSSSVITQ--------APSTNRQIGPVPGSLSSLLHLRNRQRQPLPASMPGTLPDPTMQGSSAVLMPMERQMSMGSNMMGMQGPAHNNSCSSPHVPSMHSEAKLRLKAALAHHPGGMANGSMNSMGHMMEMMPSRQDQTGHHHMHSHP-------------HQHMQGPPHG-YPHHGHHHPSHAQSVHHHPQSHGHHNSHP-AHMHPAHGHQTSPHQAMHS-AASQLSPAAQQMQPTQTLQSPPPSGGRRRRVVD-----------------------------EDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEV--------TMLKNEVTQLKQLLLTHKNCPITTMQKESQGYLSPESSPAGSPTPVT-QQQVIQHNTITTSSTA------------PNHCTDINPIH-----------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0R4IL04-1", "uniprot_id": "A0A0R4IL04_DANRE", "id": "A0A0R4IL04-1", "name": "Cyclic AMP-responsive element-binding protein 5", "aln": "------MMNVDQDRPFVCIAPGCSQS-FQREDHLIIHR---HKHEMTLKFPSIKCDSMLSDQTPTPTRFLRDCEEVGLFTDL------ELNQSQTEEQTKPNFSAQT--------SAQRQPHTETQPEQGQ---HQQFQPQQQQSCALAH--------LNQNQLQTHSSQCQSQCTATYSSSNKQSAPSCLHSRQTNTVKSN-----MNMESQMSMNSSIIGIPGPAHSGSCSSVQ----------RSKVIPAHSQPAVSNGSQNPLCHMMEMMPSQ--PHPLSHLQSAS-------------HHHAS-YQQHCHSQSPQRLAHQHQSQDQSHHSHAHHSTPSHLPLGPSH--QNAP-PLSHQPIPIQMSSTPKQSHCPQ--SPPQPATGRRRRTAE-----------------------------DDPDERRRKFLERNRAAATRCRQKRKVWVSSLERKAEELTHTNLQLQNEV--------TSLRTEVTQLKQILLTHKDCPVSVRQRETQSGIG---SPTGSPVHSH----AIQHNSISTSSTLPR-------GHLTTHSHSTSNTQL----------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q2PE13-1", "uniprot_id": "Q2PE13_DROME", "id": "Q2PE13-1", "name": "", "aln": "-MDTAGDMDHLASVSFGDFETKSPEGDVSCYQNFRAQT---EHVSLDISLGQKSDTLFAADQTPTPTRLIKNCDEVGLFEDL-------------------------------------------------------------------------------------------QHVNPFDIGFQQAAERNVSGTPSRPEARPN-------DGESLHTPQVYPVEAPTVVSVPSENQVPQSVSCGDMDVDQLLATTVTSPSKASQDGPPPLQLIQPQVLTWVLPAQSVPIS-------------IATVDCNRNRVKPTGAIHPFILPKPTAKELNKTSKRPEPILVSCNPPN-----NEPSSASLTPTSQLPIKERLKAIIHSNNNRRSFSTPPKAAK-----------------------------AKDRSRDEDCMERRRAAASRYRNK-------MRNEHKDLIKQNAQLQQEN--------QELHERISRLEKELQQHRSHSSLAGVVADQLRIP----PSSIHLLINVPNVLVPSSASNASAAKK---------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q02100-1", "uniprot_id": "SKO1_YEAST", "id": "Q02100-1", "name": "CRE-binding bZIP protein SKO1", "aln": "-MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPSLPKELSRNNSTSTITQHSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQRPTIISPPILTPGGSKRLPPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSSTSGSLYPNSSSPSGTSLIRQPRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNESNIRTGLTPGILTQSYNYPVLPSINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTVNGTPLTPGLSSLLNLPSTGVLANPVFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAVKMDNPAEFNAIEHSAHNHKENENLTTQIENNDQFNNKTRKRKRRMSSTSSTSKASRKNSISRKNSAVTTAPAQKDDVENNKISNNVTLDENEEQERKRKEFLERNRVAASKFRKRKKEYIKKIENDLQFYESEYDDLTQVIGKLCGIIPSSSSNSQFNVNVSTPSSSSPPSTSLIALLESSISRSDYSSAMSVLSNMKQLICETNFYRRGGKNPRDDMDGQEDSFNKDTNVVKSENAGYPSVNSRPIILDKKYSLNSGANISKSNTTTNNVGNSAQNIINSCYSVTNPLVINANSDTHDTNKHDVLSTLPHNN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. . . . . . . . : :.. . : : . .. ..: . .: : . . : .. :**.*.**:: *:: :... : :* : .:: . . : : ... . .. ", "identical_positions": 7, "similar_positions": 59, "identity": "1.08%" }, { "cls_id": "homologset.agr.HGNC:16846", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5XW36-1", "uniprot_id": "A0A8I5XW36_RAT", "id": "A0A8I5XW36-1", "name": "Pre-mRNA-splicing regulator WTAP", "aln": "--------------------------------------------------------MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNS-------NDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQ----------QQQ--SQASAPS-TSRTTSSEPVDQAE---ATS----KDCSRLANGP-----------SNGSSSRQRTSGSGFHREGSTPEDDFPSSS--------GNGNKASNSSEERTGRG-SSYIN------------PLSAGYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRH-VQNGLDSSVN---------VQGSIL--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ER69-1", "uniprot_id": "FL2D_MOUSE", "id": "Q9ER69-1", "name": "Pre-mRNA-splicing regulator WTAP", "aln": "--------------------------------------------------------MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNS-------NDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQ----------QQQ--SQASAPS-TSRTTSSEPVDQAE---VTS----KDCSRLANGP-----------SNGSSSRQRTSGSGFHREGSTPEDDFPSSS--------GNGNKASNSSEERTGRGGSSYIN------------PLSAGYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRH-VQNGLDSSVN---------VQGAVL--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15007-1", "uniprot_id": "FL2D_HUMAN", "id": "Q15007-1", "name": "Pre-mRNA-splicing regulator WTAP", "aln": "--------------------------------------------------------MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNS-------NDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQ----------QQQ--SQASAPS-TSRTTASEPVEQSE---ATS----KDCSRLTNGP-----------SNGSSSRQRTSGSGFHREGNTTEDDFPSSP--------GNGNKSSNSSEERTGRGGSGYVN------------QLSAGYESVDSPTGSENSLTHQSNDTDSSHDPQEEKAVSGKGNRTVGSRH-VQNGLDSSVN---------VQGSVL--------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7SXL7-1", "uniprot_id": "FL2D_DANRE", "id": "Q7SXL7-1", "name": "Pre-mRNA-splicing regulator WTAP", "aln": "--------------------------------------------------------MTNEEPLPKKVRLSESDMKTLTREELCTRWKQHETYVQMLEAKYADLNS-------NDVTGLKESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSAAQLRSSMVDPAINLFFLKMKAELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLRETRQQLSQMN----------QTQGTSSGAGPSRTSPSTASEPSTQSEPANASSSNVGKDCGRVSNGP-----------SNGNSSQRGASGSSLYREASSADEDYPPSPSVSSPTHDGISKLSNHSEDAVSQRGGEGYVT------------QLSAGYESVDSPTGSETSVTQHSNDTDSNADSHEAAAVP-KGSRTAGTRHSTQNGLDSSAAAVATNTSNASAGSVL--------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9Y091-1", "uniprot_id": "FL2D_DROME", "id": "Q9Y091-1", "name": "Pre-mRNA-splicing regulator female-lethal(2)D", "aln": "MSVAAMTMDDQRPCMNSYDKMPPTKYEQNLNILNSSQNSGATGGPASPTPSGLEDHHHHHHPHPHHHHHQEQQQQQQQQQHLQQQQQQQQQQHAAAVAEAVAAAEQRQRLLEDEIENLKLEQVRMAQQCADAQRREKILMRRLANKEQEFQDYVSQIAEYKAQQAPTALALRTALLDPAVNLLFERLKKELKATKAKLEETQNELSAWKFTPDSNTGKRLMAKCRLLYQENEELGKMTSNGRLAKLETELAMQKSFSEEVKKSQSELDDFLQELDEDVEGMQSTILFLQQELKTTRDRIQTLEKENAQLKQAIKDEVVAPAAATNGGTNTTINKLETIHEDACMANNPTNPDCYNGNTNNEQIAAVPQIPLSDDGSNMNGNAARLARKRNYQEEEALPTVVVVPTPTPVGNNVQEAPPIREVTAPRTLPPKKSKLRGITTRRNSQLEEDHQPVTTPVAVPMIVDNAVAGMASEEAAAAAAAVNNSNTGIIPETG-VQVGVPVEGGDPG---APAAPGRILTRRRSVRMQQNGSGAVDYST", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :..* *:: : .* : : ::.* : :* : .: . . ::: .*: .: :: ** :: ***:**: ***.****:*: .:** * * *:. **::::***:**:* ::* **: ** ***::*************:***:******:* ***:***: *:**:*:**:***:**.:***:*.**.**:**: :***:*********.***:*: **::: : : : : .:... : :* .: * :. ** . .. *:..*. . :. :. :: *. * . . : . *. .::.* :*.. : : . *. . ** ... .* *: . * :* ", "identical_positions": 128, "similar_positions": 129, "identity": "23.7%" }, { "cls_id": "homologset.agr.HGNC:16848", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LX02-1", "uniprot_id": "F1LX02_RAT", "id": "F1LX02-1", "name": "", "aln": "MWQFSALLFFLLPGCSTAQDPVTGPEEVSSQEQGSLIVQCQYASHWKDYRKYWCRGAEWSSCKILVETDASECLVKENRVSIRDDQRNFIFTVTMEDLRMSDAGIYWCGIVKSGYDPMFKVRVGIEPGCSTAQDLLTGPKEVSSQEQGSLTVRCQYGSWWKDYRKYWCRGAEWSSCKILVETDASECLVKKNRVSMRDNQTNFIFTVTMEDLRMSDAGIYWCGITKAGYDPMFKVHVSIDPGSSPWCCT-IPEPTT----------------------------------------------------------------------------SSPVDPQPSMTTIDT---IPAPSPQPRSLLSSPYFCILLFLELPLFLCMLCAILWVNRPQTWSGR--QGIWPYHESQ-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8I6A7B0-1", "uniprot_id": "A0A8I6A7B0_RAT", "id": "A0A8I6A7B0-1", "name": "", "aln": "MWQISALLFLFLP------------------------------------------------------------------------------------------------------------------GYSTAQDLLIGPEKVSGQEQGSLTARCQYASHWKDYSKYWCRGSSWHLCGILVETDASERLVKKNRVSIRDNQTHFIFTVTMEDLRMSDADIYWCGITKVGYDLMSKIHLSIDPGWSPGSSKKILEPTR----------------------------------------------------------------------------SSPVDTQPGVTTNDT---IPASS--PRYILGSLYLCILVFLELPLFLCMLCAVLWVNRPQTWSGR--QGIQPYYENQ-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6SJQ5-1", "uniprot_id": "CLM3_MOUSE", "id": "Q6SJQ5-1", "name": "CMRF35-like molecule 3", "aln": "MWQFPALLFLFLP------------------------------------------------------------------------------------------------------------------GCCTAQDPVTGPEEVSGQEQGSLTVQCRYDSGWKDYKKYWCRGAYWKSCEILVETDASEQLVKENRVSIRDDQTDFIFTVTMEDLRMSDADIYWCGITKAGTDPMFKVNVNIDPEISTTIMTTTATVLP---------------STVLTSTVLTSTVL---------------------------------------------TPTTPTTESIGTENIGQ---VTQNSLFIWSLLSSISFLLMVFVVVPLLLSMLSAVLWVNRPQRHYGGGEIGLVETHRSDALDGEKHFPGDEK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A7W1-1", "uniprot_id": "A2A7W1_MOUSE", "id": "A2A7W1-1", "name": "", "aln": "MWQFPALLILFLP------------------------------------------------------------------------------------------------------------------GCCTAQDPVTGPEEVSGQEQGSLTVQCRYDSGWKDYKKYWCRGAYWKSCEILVETDASEQLVKENRVSIRDDQTDFIFTVTMEDLRMSDADIYWCGITKAGTDPMFKVNVNIDPEISTTIMTTTATVLP---------------STVLTSTVLTSTVL---------------------------------------------TPTTPTTESIGTENIGQ---VTQNSLFIWSLLSSISFLLMVFVVVPLLLSMLSAVLWVNRPQRHYGGGEIGLVETHRSDALDGEKHFPGDEK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A7W0-1", "uniprot_id": "A2A7W0_MOUSE", "id": "A2A7W0-1", "name": "", "aln": "MWQFPALLILFLP------------------------------------------------------------------------------------------------------------------GCCTAQDPVTGPEEVSGQEQGSLTVQCRYDSGWKDYKKYWCRGAYWKSCEILVETDASEQLVKENRVSIRDDQTDFIFTVTMEDLRMSDADIYWCGITKSGYDPMFKVNVNIDPEISTTIMTTTATVLPSTVVPSTVLPCTVVPSTVLTSTVLTSTVLPSTVLTSTVLPSTVLTSTVLPSTVRTSTVLPSTVLPSTVRTSTVRTSTTPTMESIGTENIGQ---VTQNTLFIWSLLSSISFLLMVFVVVPLLLSRLCAVHWVNRPQRHYGEVEIGLVETHRSDAQDEEKHFPGDEK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8VCH2-1", "uniprot_id": "CLM5_MOUSE", "id": "Q8VCH2-1", "name": "CMRF35-like molecule 5", "aln": "MWQFSALLLFFLP------------------------------------------------------------------------------------------------------------------GCCTAQDSVTGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPQRSCDILVETDKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSDAGIYWCGITKGGPDPMFKVNVNIDQAPKSSMMTTTATVLK---------------------------------------------------------------------------SIQPSAENTGKEQVTQSKEVTQSRPHTRSLLSSIYFLLMVFVELPLLLSMLSAVLWVTRPQRCFGRGENDLVKTHSPVA------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6UXZ3-1", "uniprot_id": "CLM5_HUMAN", "id": "Q6UXZ3-1", "name": "CMRF35-like molecule 5", "aln": "MWLSPSLLLLILP------------------------------------------------------------------------------------------------------------------GYSIAAK-ITGPTTVNGSEQGSLTVQCAYGSGWETYLKWRCQGADWNYCNILVKTNGSEQEVKKNRVSIRDNQKNHVFTVTMENLKRDDADSYWCGTERPGIDLGVKVQVTINPGTQTAVSEWTTTTAS-----------------------------------------------------------------------------------LAFTAAAT---QKTSSPLTRSPLKSTHFLFLFLLELPLLLSMLGTVLWVNRPQRRS---------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** .:**:::** * . * . : ** *...******.:* * * *: * *: *:* * ***:*: ** **:****:**:* ..:******:*: .**. **** : * * *:::.*: .. . * * : ::.:: :**:*. * :: **.*** ", "identical_positions": 69, "similar_positions": 49, "identity": "16.35%" }, { "cls_id": "homologset.agr.HGNC:16849", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R0Q4-1", "uniprot_id": "MO4L2_MOUSE", "id": "Q9R0Q4-1", "name": "Mortality factor 4-like protein 2", "aln": "-------------------------------------------------------------------------------------MSSRKQASQTRGQQSAEEDN--FKKPTRSNMQ--RSKMRGAASGKKSAGSQ-PKNLDPALPGRWGGRSAENPP----------SGSVRKTRKNKQKAPGNGD-GGSTS--------------EVPQPPRKKRAR----------------------------ADPTVESEEAFKSRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDN-KEYAVNEVVGGIKEYFNVMLGTQLLYKFERPQYAEILLAHP--DAPMS--QIYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASD--------YKVASADYHRKAL--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6QI89-1", "uniprot_id": "MO4L2_RAT", "id": "Q6QI89-1", "name": "Mortality factor 4-like protein 2", "aln": "-------------------------------------------------------------------------------------MSSRKQASQTRGQQSAEEDN--FKKPTRSNMQ--RSKMRGAASGKKSAGSQ-PKNLDPALPGRWGGRSAENPP----------SGSVRKTRKNKQKTPGNGD-GGSTS--------------EVPQPPRKKRAR----------------------------ADPTVESEEAFKSRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDN-KEYAVNEVVGGIKEYFNVMLGTQLLYKFERPQYAEILLAHP--DAPMS--QIYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASD--------YKVASADYHRKAL--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15014-1", "uniprot_id": "MO4L2_HUMAN", "id": "Q15014-1", "name": "Mortality factor 4-like protein 2", "aln": "-------------------------------------------------------------------------------------MSSRKQGSQPRGQQSAEEEN--FKKPTRSNMQ--RSKMRGASSGKKTAGPQ-QKNLEPALPGRWGGRSAENPP----------SGSVRKTRKNKQKTPGNGD-GGSTS--------------EAPQPPRKKRAR----------------------------ADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDN-KEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHP--DAPMS--QVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASD--------YKVASAEYHRKAL--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9Y0I1-1", "uniprot_id": "EAF3_DROME", "id": "Q9Y0I1-1", "name": "NuA4 complex subunit EAF3 homolog", "aln": "MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHY---AGWSKNWDEWVPENRVLK--YNDDNVKRRQELARQCGERSKKDNKKGSAKAKKMEQM--RNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTAR-PGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHP--DTPLS--ELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSN--------FINVDPEYVRNAQ--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12432-1", "uniprot_id": "EAF3_YEAST", "id": "Q12432-1", "name": "Chromatin modification-related protein EAF3", "aln": "--------------MVDLEQEFALGGRCLAFHGPLMYEAKILKIWDPSSKMYTSIPNDKPGGSSQATKEIKPQKLGEDESIPEEIINGKCFFIHYQGWKSSWDEWVGYDRIRAYNEENIAMKKRLANEAKEAKKSLLEQQKKKKLSTSLGGPSNGGKR---KGDSRSNASISKSTSQSFLTSSVSGRKSGRSSANSLHPGSSLRSSSDQNGNDDRRRSSS---------------------------LSPNMLHHIAGYPTPKISLQIPIKLKSVLVDDWEYVTKDKKICRLPADVTVEMVLNKYEHEVSQELESPG-SQSQLSEYCAGLKLYFDKCLGNMLLYRLERLQYDELLKKSSKDQKPLVPIRIYGAIHLLRLISVLPELISSTTMDLQSCQLLIKQTEDFLVWLLMHVDEYFNDKDPNRSDDALYVNTSSQYEGVALGM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. : : * :* :: : : : * : .*.: . . . *. * . : : :. .:. .. * .* : ::* * : . * ::.::** :** *.:** *.::::: .***. .*: : ::* .. . .: :.: *: **: **. ***::** ** ::: . : *: .:**: *****: : ::: :.:* :* *: .*** :* : *. .: : ...:* * ", "identical_positions": 54, "similar_positions": 98, "identity": "12.11%" }, { "cls_id": "homologset.agr.HGNC:1685", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P13379-1", "uniprot_id": "CD5_MOUSE", "id": "P13379-1", "name": "T-cell surface glycoprotein CD5", "aln": "--MDSHEVLLAATYLLGTLAAFCLGQSGRGGLDIQVMLSGSNSKCQGQVEIQMENKWKTVCSSSWRLSQDHSKNAQQASAVCKQLRCGDPLALGPFPSLNRPQNQVFCQGSPWSISNCNNTSSQDQCLPLSLICLEPQRTTPPPTTTPPTTVPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSWGGTILYKAKDRPLGLGNLICKSLQCGSFLTHLSGTEAAGTPAPAELRDPRPLPIRWEAPNGSCVSLQQCFQKTTAQEGGQALTVICSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWEALCDSSAARGRGRWEELCREQQCGDLISFHTVDA-DKTSPGFLCAQEKLSQCYHLQKKKHCNKRVFVTCQDPNPAGLAPGTVASIILTLVLLVVLLAMCGPLVYKKLVKKFRQKKQRQWIGPTGVNQNMSFHRSHTATVRSQVENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P51882-1", "uniprot_id": "CD5_RAT", "id": "P51882-1", "name": "T-cell surface glycoprotein CD5", "aln": "--MDSHEVLLAATYLLGTLAAFCLGQSGRGFVGAQVMLSGSNSKCQGLVEVQMN-GMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLALGHLTLWNRPKNQILCQGPPWSFSNCS-TSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTMPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGSFLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVVCSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNLISFHVMDA-DRTSPGVLCTQEKLSQCYQLQKKTHC-KRVFITCKDPNPVGLAPGTVASIILTLVLLVVLMVMCGPLIYKKLVKKFRQKKQRQWIGPTGVNQSMSFHRSHTATVRSQVENPAASHVDNEYSQPPRNSRLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P06127-1", "uniprot_id": "CD5_HUMAN", "id": "P06127-1", "name": "T-cell surface glycoprotein CD5", "aln": "MPMGSLQP-LATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCS-HSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.* : **: **** *.* ***: . . *. *: ******* :*: :: : ***.** *.. ::..:** **::* ** **:** : *:..::* * *:***. * . * .*.* *****:*** .* . *** ************. * :*:******.** **** *:*: :. .* *::*:.*******.**. *:. : *.* *: :****:*: *.**.**::**:* . *:..:.*:::**.**************:*** .**** :** ******:**. ****:*:*****.: *::.:** * ** *.:*.::*****:.* ::. *:**:**:****.***.********:*******:.:**** *********************:**.*****.*******:.***:***************:*************** ************: ****", "identical_positions": 294, "similar_positions": 117, "identity": "59.15%" }, { "cls_id": "homologset.agr.HGNC:16850", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V897-1", "uniprot_id": "G3V897_RAT", "id": "G3V897-1", "name": "RNA polymerase-associated protein CTR9 homolog", "aln": "-------------MSRGSIEIPLRDTDEVIELDFDQLPEGD--EVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDT-LAAYYVQQARKEKNKDNKKDLITQATLLYT---MADKIIMYDQNHLLGRACFCLLEGDK-MDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKN---------GVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNT---EVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYA-----ASEDQEKRDIAKGHLKKVTEQYPD--------------DVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLR--LGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQK--KFERILKQPATQSDTYSMLALGNVWLQTLHQPTRDR-----EKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKKRKGSGSEQEGEEEEGGERKKKRRRRPPKGEEGSDDDETENGPKPKKRRPPRAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNS--DSDDDERPNRRASSESDSDDNQNKSGSEAGSPRRSGRQESDEDSDSDQPSRKRRRSGSEQSDNESAQSGRSPSGGSENENDSRPVSPSAESDHESEQGSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q62018-1", "uniprot_id": "CTR9_MOUSE", "id": "Q62018-1", "name": "RNA polymerase-associated protein CTR9 homolog", "aln": "-------------MSRGSIEIPLRDTDEVIELDFDQLPEGD--EVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDT-LAAYYVQQARKEKNKDNKKDLITQATLLYT---MADKIIMYDQNHLLGRACFCLLEGDK-MDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKN---------GVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNT---EVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYA-----ASEDQEKRDIAKGHLKKVTEQYPD--------------DVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLR--LGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQK--KFERILKQPATQSDTYSMLALGNVWLQTLHQPTRDR-----EKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPVSKKKKRRKGSGSEQEGEEEEGGERKKKRRRRPPKGEEGSEEEETENGPKPKKRRPPRAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNS--DSDDDERPNRRASSESDSDDNQNKSGSEAGSPRRSGRQESDEDSDSDQPSRKRRRSGSEQSDNESVQSGRSPSGASENENDSRPASPSAESDHESEQGSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6PD62-1", "uniprot_id": "CTR9_HUMAN", "id": "Q6PD62-1", "name": "RNA polymerase-associated protein CTR9 homolog", "aln": "-------------MSRGSIEIPLRDTDEVIELDFDQLPEGD--EVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDT-LAAYYVQQARKEKNKDNKKDLITQATLLYT---MADKIIMYDQNHLLGRACFCLLEGDK-MDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKN---------GVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNT---EVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYA-----ASEDQEKRDIAKGHLKKVTEQYPD--------------DVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLR--LGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQK--KFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDR-----EKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSEN--DSRPASPSAESDHESERGSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P89105-1", "uniprot_id": "CTR9_YEAST", "id": "P89105-1", "name": "RNA polymerase-associated protein CTR9", "aln": "MTNAMKVEGYPSMEWPTSLDIPLKASEELVGIDLETDLPDDPTDLKTLLVEENSEKEHWLTIALAYCNHGKTNEGIKLIEMALDVFQNSERASLHTFLTWAHLNLAKGQSLSVETKEHELTQAELNLKDAIGFDPTWIGNMLATVELYYQRGHYDKALETSDLFVKSIHAEDHRSGRQSKPNCLFLLLRAKLLYQKKNYMASLKIFQELLVINPVLQPDPRIGIGLCFWQLKDSKMAIKSWQRALQLNPKNTSASILVLLGEFRESFTNSTNDKTFKEAFTKALSDLNNIFSENQHNPVLLTLLQTYYYFKGDYQTVLDIYHHRILKMSPMIAKIVLSESSFWCGRAHYALGDYRKSFIMFQESLKKNED-NLLAKLGLGQTQIKNNLLEESIITFENLYKTNESLQELNYILGMLYAGKAFDAKTAKNTSAKEQSNLNEKALKYLERYLKLTLATKNQLVISRAYLVISQLYELQNQYKTSLDYLSKALEEMEFIKKEIPLEVLNNLACYHFINGDFIKADDLFKQAKAKVSDKDE-------SVNITLEYNIARTNEKN-DCEKSESIYSQVTSLHPAYIAARIRNLYLKFAQSKIEDSDMSTEMNKLLDLNKSDLEIRSFYGWYLKNSKERKNNEKSTTHNKETLVKYNSHDAYALISLANLYVTIARDGKKSRNPKEQEKSKHSYLKAIQLYQKVLQVDPFNIFAAQGLAIIFAESKRLGPALEILRKVRDS-LDNEDVQLNLAHCYLEMREYGKAIENYELVLKKFDNEKTRPHILNLLGRAWYARAIKER--------------SVNFYQKALENAKTALDLFVKESSKSKFIHSVKFNIALLH------------------------FQIAETLRRSNPKFRTVQQIKDSLEGLKEGLELFRELN------DLKEFNMIPKEE----LEQRIQLGETTMKSALERSLNEQE-----------------EFEKEQSAKIDEARKILE------------ENELKEQGWMKQEEEARRLKLEKQAEEY-----------RKLQDEAQKLIQEREAMAISEHNVKDDSDLSDKDNEYDEEKPRQKRKRSTKTKNS----GESKRRKAAKKTLSDSDEDDDDVVKKPSHNKGKKSQLSNEFIE-DSDEEEAQMSGSEQNKND--------------------------DNDENNDNDDNDGLF-----------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::***: ::*:: :*:: .* :: ::* :*::: . *:::** * ::***:* :**:* * : . * : :* . ** ....:::: .: :* : :: : :.: : : : *: .* .* :.. .*: * .** * ** :* : ::**:* .:* ::: * ** .: *:*:* ** :*:. : * ::.***:**.* ..* : : : *:.:. ::* :: .:. *.. :: : **::*. * .:::** **..* .: * : : .: : :**.: .*:.:. ** ::* : :: : .. :*. :**** * .. *:: **:: *: . * *** *** *. ::. :.:*:: : :* : .*:: ::*: * : : * : : * :: ::* *:***:.. ** *:: :*.. * : :.. : * ::.:* .**:** * : .::*.:*.:: ** *: . :* :*:.* : : * ::: *::*:.. : *: * .:* .:* ..:: .. *:*::::*.*::: :: .:.* **.*: :*: :*::**: *. *::**:*:. ::*.. : * ::: :**:: * .** ***** *:* ::* .*:: ** *:** :.:. :* * : . ::* :* ::: ** : * .:: .*.*: * : .. :: * * * :: * ::: :. .:: .:. . *: * :** : :* .: *** **** * *.* : : . .* **:: . . *: : : *.* :* * *::.. * * *: ::: * : * :* : .. . : ::*..: :*..*:. **:* : : .:..** .:.:: : .: ****::::. .:.. : * *:: : *. ..: : *****..*: .:.*.: ..**:* ", "identical_positions": 241, "similar_positions": 408, "identity": "19.51%" }, { "cls_id": "homologset.agr.HGNC:16851", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZUI1-1", "uniprot_id": "A0A8I5ZUI1_RAT", "id": "A0A8I5ZUI1-1", "name": "Ras-specific guanine nucleotide-releasing factor RalGPS1", "aln": "-----------------------------------------------------------------------------------MYKRNGLMAS---------VLVTSATPQG--------SSSSDS----------------LEGQSCDHASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS---PRLVSSKEDLAGPSAGSSSARFRRRPTCPDASVAGSLPTPPVPRHRKSHSLG-------------NNLMCQLSVVDSKSATFPS--EKARHLLDDSVLESRS---PRRGLTHTSSTAITNGLSLGSSESSEFSEEMSAGLES----------------------------PTSPCTCTVGSSATVPTMEGPLRRKTLLKEGRKPALPSWTRYWVVLSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQ-VPANLMSFE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AR50-1", "uniprot_id": "RGPS1_MOUSE", "id": "A2AR50-1", "name": "Ras-specific guanine nucleotide-releasing factor RalGPS1", "aln": "-----------------------------------------------------------------------------------MYKRNGLMAS---------VLVTSATPQG--------SSSSDS----------------LEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS---PRLVSSKEDLAGPSAGSSSARFRRRPTCPDTSVAGSLPTPPVPRHRKSHSLG-------------NNLMCQLSVVESKSATFPS--EKARHLLDDSVLESRS---PRRGLTHTSSTAITNGLSLGSSESSEFSEEMSAGLESRGRLYATLGPNWRVPVRNSPRTRSCVYSPTSPCTCTVGSSATVPTMEGPLRRKTLLKEGRKPALSSWTRYWVVLSGATLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSSRPQ-VPANLMSFE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5JS13-1", "uniprot_id": "RGPS1_HUMAN", "id": "Q5JS13-1", "name": "Ras-specific guanine nucleotide-releasing factor RalGPS1", "aln": "-----------------------------------------------------------------------------------MYKRNGLMAS---------VLVTSATPQG--------SSSSDS----------------LEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS---PRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLG-------------NNMMCQLSVVESKSATFPS--EKARHLLDDSVLESRS---PRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLES----------------------------PTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQ-VPANLMSFE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0UXH6-1", "uniprot_id": "RGPS1_DANRE", "id": "B0UXH6-1", "name": "Ras-specific guanine nucleotide-releasing factor RalGPS1", "aln": "-----------------------------------------------------------------------------------MYRRNGLPAS---------VSITSRNTQD--------SSSSES----------------LDGRSLDSA-KSFDAVVFDMLKVTPEEFASQITLMDAPVFKAIQPEELASCGWNKKEKHSLSPNVVAFTRRFNQVSFWAVREILTAQTLKIRAEILGHFIKIAKKLLELNNLHSLVSVVSALQSAPIFRLSKTWALISRKDKATFEKLDFLTSKEENYNRMREYTRSLKMAPCIPYLGIYLFDMTYIDSAYPASDSIIETEQRTNQMNNLLRIISDLQVSCKYDHLITLPHVQKYLMSVRYIEELQKFVEDDNYSLSLKIEPGNSS---PRLVSSKEDLGGPSEVSMSVRYNRRPTCPDTSVVAHLPTPPPARHRKSHSLG-------------NNMMCQFGVVESKSATFPEK-EKARHLLDDSFLESHS---PVR--NHTHDSVFTNGISLGSRESS-FSDELSSTVER-GRMYATLGPNWRVPICNSPRSRSYIYSTPGAVSSYECSTLSSITIEGPLRRKTLMKEGKKPTLSSWKRYWIVLSGSILIYFGSKALRANERRHYKSRPCKKITLTGWMVVLPDNPEHPNIFQLTDPDRGNVYKFQTGSRFSAIIWHRHLAEACRSTRPQ-MPANLMSFE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q0E949-1", "uniprot_id": "Q0E949_DROME", "id": "Q0E949-1", "name": "", "aln": "MMRYSEISRDLSTDNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTRVSKQRSPNTNGSAHTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLR-LPCIPYLGLFLTDLIYIDLAHPHKG-GLEPEQRRNKMNNILRVISNYQQSN-YKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLEHSDALSQADLT------------------SLESAEGIMCDFTGSDCDLMSPEAAAAMHGCVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKNTFELCHRTLGTVYRFRTDSPQMTHLWSNAICKLATMRVPKPLPTNLMSFE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:.: : .. : :.* :. ***.:* :. . . : *. ***::. *:*..: :*.****:* *** ***:**:**.*.**:** :**:****:***:.***.*:***.*: * ****: **:*:**** ********.:::**:***.*:**:**** :.:**: :*::*. : *.::*: . *.* .**: *.*****::* *: *** *:* .. :* *** *:***:**:*:: * * *.** . .**** *:*******::.*:*:*. **.:**...* . ****.: . *: . *: * . ***.:*** :: * : :: . .*:.. :.*:::.. ..:* * : : . * . . .*: :* . .. : ::.* :****: ***:**::.** ***: : . *:*: .*:::..:*..:* * * .: ** . :.*:.:* : *:* . *.**:*:*.* : :* . : . . *: :*:******", "identical_positions": 205, "similar_positions": 189, "identity": "28.35%" }, { "cls_id": "homologset.agr.HGNC:16852", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZUE4-1", "uniprot_id": "D3ZUE4_RAT", "id": "D3ZUE4-1", "name": "", "aln": "-------------------------------------------------------MDKVGKMWNNFKYRCQNLFSHEGG-SRSENVDMNANRCLSVKEKSVSLGEAAPRQQSSPLRENIALQLGLSPSKTFSRRN------QNCAAEIPQVVEISIEKDSDSSATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMHDMDS------VSSRAVGSRSLRQRLQDTVGLCFPMRTY--SKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHST--FFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGS-----------------------AIP--QTNCDSEEDSTTLCLQSRRQKQRQVSGDSHSHISRQ-GAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREP-VKAK-----------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O54928-1", "uniprot_id": "SOCS5_MOUSE", "id": "O54928-1", "name": "Suppressor of cytokine signaling 5", "aln": "-------------------------------------------------------MDKVGKMWNNLKYRCQNLFSHEGG-SRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRN------QNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDS------VSSRAVGSRSLRQRLQDTVGLCFPMRTY--SKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHST--FFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGS-----------------------AIP--QTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQ-GAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREP-VKAK-----------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75159-1", "uniprot_id": "SOCS5_HUMAN", "id": "O75159-1", "name": "Suppressor of cytokine signaling 5", "aln": "-------------------------------------------------------MDKVGKMWNNFKYRCQNLFGHEGG-SRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRN------QNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDS------VSSRTVGSRSLRQRLQDTVGLCFPMRTY--SKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHST--FFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSS-----------------------AIP--QANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQ-GAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREP-VKAK-----------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B3H1-1", "uniprot_id": "A0A8M2B3H1_DANRE", "id": "A0A8M2B3H1-1", "name": "", "aln": "--------------------MRDSSEYNSYNSLLLQTKDGCEVTYTIKKGCGLQSVENVGKMWGNLRSRCQALFHSDGSESHLCSQDLDCAHCVLDLDRG-AHAEPYETRSSTPSRN-----LSPLPLATGGRRS------HNCVADIPQIVEISIDKESED-ARRGP-LVRRDSYSRHAPWGGKKKHSCSTKTQSSLEADRRTGRSRGSTARRERRYAVSSIQEINDS-VEVGSSGRSLSSRSLRQRLRDTVGLCLPLPTHRRSQSAKGQVSSKRKIHLTELMLETCPFPPGSDLANKWHLIKQHTAPVSPHSSSALFDAFDSAHSSPEDEEERLRERRRLSIEEGVDPPPNAQIHTLEATSKSSSLYKLGPKMAPGVGETLGEGRSLGTVSSISGGLSGIAAQVPTSMAVPSHTVDCDSEEDSTTLCLQTRRPKQRHASGD--THCSRQPGPWKVHTQIDYIHCLVPDLQAITALPCYWGVMDRYQAEALLDGRPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSACMFFEPLLTAPLHRTFPFSLQHLARSSICRHTTYDGIGALPLPPTMQDFLKEYHYKQKVRVRWLEREPPFKVK-----------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8INY1-1", "uniprot_id": "Q8INY1_DROME", "id": "Q8INY1-1", "name": "", "aln": "MGHHLSKFSARANSQEKRNPTASSSPREAAALVETISLDEEELQVEEILTEATVSAATSPAEVRQIIIKIQLAKMENGNPVAAGQVESFAEVVEQEEEQQRQCADGATDDDAAALSADSLNANGQIVNVTLEGGYGEVGVVTNRTAGSSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNANCPLEADDDDDLDESLLRRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNSNSCCRSRSSKALSMGAATSSASGSASTSVSTSTSSKRRCCKCKCRDAIRGLRDMLPSSSSSVSNKKDAAAVVAMVPRKSRTADRRSTPPTLGTSSGGSQRRMQSQRIRNSVAVPDASHHHHQLIIRITSPG-----FVVESPNGGRVTVVTEPAPQSPQTPPRPRPLATVAPAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHYKQKLRVKPIDQNTPMPYYGNVXREEQQVGFTYYEDVESGSEVDEDDDEGVNIRVSYVQHAEVVAQLQQVTTASGPSAPSSSRSSNLQEHLSRLPNRMAAAFGRMSANLNCYQKTVATPERHSNSS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: : * :*. . : :: .: .::. . . * .: . . : : :. *. . .: . * **: : . .:. :..*: . * .. * : :: :: :. .** :.* . . *:.:: .: . *: ... ..* ... *:: . . :.: : : .: *. .::. : .:. . .: *: ::: . . :: .: .. . :. ::. :.* :*. .**:***::******* ** . *** ****:** **:*:*************::****:**:*.********* .*:****.****** :.************:. ***** ** .*:* .**** :.*: * *:****. : ** ::.:*********:**: ::::. . ", "identical_positions": 132, "similar_positions": 158, "identity": "17.79%" }, { "cls_id": "homologset.agr.HGNC:16853", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JM04-1", "uniprot_id": "IPO13_RAT", "id": "Q9JM04-1", "name": "Importin-13", "aln": "MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPE-IQYFGASALHIKISR--------YWSDIPTDQYESLKAHSFTQITRFASGSKIVLTRLCVALASLALSMMPD-------------AWPCAVADMVRLFQAEDSP-VDSQGRCLALLELLTVLPEEFQTSRLPQYRKGL----------------------VRASLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQ-LEVPLQDCEALIQAAFAALQ-----------------DSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALG---ENHSRALLDQVEHWQSFLALVN--------------------------MIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQ-AVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSD--EKEQFRIYRVDISDTLMYVYEMLG-AELLSNLYDKLGRLLTSSE------EPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISIS---------------------NVQLADTVMFTIGALSEWLADHPVMINSVLPLVLH---------------ALGNPELSVSSVSTLKKICRECKYELPPYAANIVAVSQDVLMKQIHKTSQC-MWLMQALGFLLSALQ---VEENLKNLHSLISTYIQQLEKLAEEI-PKPSNKLAIVHILGLLSNLFTTLDVSHHEDDHE--GPELRKLPVPQGPNPVVVVLQQVFQLIQKVLS-KWLSDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPR----DHPDIVDSFMQLLAQALKRKPDLFQCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPR----CGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K0C1-1", "uniprot_id": "IPO13_MOUSE", "id": "Q8K0C1-1", "name": "Importin-13", "aln": "MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIDNKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPE-IQYFGASALHIKISR--------YWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPD-------------AWPCAVADMVRLFQAEDSP-VDSQGRCLALLELLTVLPEEFQTSRLPQYRKGL----------------------VRTSLAVECGTVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQ-LEVPLQDCEALIQAAFAALQ-----------------DSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALG---ENHSRALLDQVEHWQSFLALVN--------------------------MIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQ-AVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSD--EKEQFRIYRVDISDTLMYVYEMLG-AELLSNLYDKLGRLLTSSE------EPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISIS---------------------NVQLADTVMFTIGALSEWLADHPVMINSVLPLVLH---------------ALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQC-MWLMQALGFLLSALQ---VEEILKNLHSLISPYIQQLEKLAEEI-PNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHE--GPELRKLPVPQGPNPVVVVLQQVFQLIQKVLS-KWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPR----DHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPR----CGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O94829-1", "uniprot_id": "IPO13_HUMAN", "id": "O94829-1", "name": "Importin-13", "aln": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPE-IQYFGASALHIKISR--------YWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPD-------------AWPCAVADMVRLFQAEDSP-VDGQGRCLALLELLTVLPEEFQTSRLPQYRKGL----------------------VRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQ-LEVPLQDCEALIQAAFAALQ-----------------DSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALG---ENHSRALLDQVEHWQSFLALVN--------------------------MIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQ-AVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSD--EKEQFRIYRVDISDTLMYVYEMLG-AELLSNLYDKLGRLLTSSE------EPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISIS---------------------NVQLADTVMFTIGALSEWLADHPVMINSVLPLVLH---------------ALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQC-MWLMQALGFLLSALQ---VEEILKNLHSLISPYIQQLEKLAEEI-PNPSNKLAIVHILGLLSNLFTTLDISHHEDDHE--GPELRKLPVPQGPNPVVVVLQQVFQLIQKVLS-KWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPR----DHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPR----CGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q9F5-1", "uniprot_id": "F1Q9F5_DANRE", "id": "F1Q9F5-1", "name": "Importin-13", "aln": "------------MDSDTAADFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWQFCWVLLRPDKVPE-IQYFGASALHTKISR--------YWSDIPAEQYDSLKSQLFSQIARFASGSKIVLTRLCVALASLALNMMPE-------------AWPGAVSEMVRMFQEDGGD-VDGRARCLALLELLTVLPEEFQTSRLPQYRKGQ----------------------VRGALGSEWTAVYPLLQQLLRQPDSPSLVKARVLKCLSSWVL-LDVPLNESEGLVEASFTALA-----------------DPELFDTAVEAIVNTISQPDSQRYVNTLLKLVPQVLQLQEQLRDAVQNGDMETSHGICRIAVSLG---ENHSRALLEQVEHWQSFLALVN--------------------------MIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDIMSFEAEKQ-AVYLQVYRPVYFQLVDVLLHKAQFPTDEEYASWSSD--EKEQFRIYRVDISDTLMYVYEMLG-AELLSNLYDKLGRLLTNTE------QTTTWQHTEALLYGFQSIAETIDVNYSDVIPGLIGLIPRININ---------------------NVQLADTVMFTIGALAEWLADHPVMLSSVLPLVLQ---------------ALGNPDLSVSSVSTLKKICRECKYDLPPYATNIVAVSQEVLIKQIHKTSQC-MWLMQALGFLLSALP---VEEILRNLHSLITPYIQQLEKLAEET-PNPSNKLAIIHILGLLSNLFTTLDITKQEDESGENAPPIKSAPPPTGPNPVVVVLQQVFALIQTVLS-KWLNDSQVVEAVCAIFEKSVKTLLHDFAPMVSQLSEMLGQMYSTIPQASALDLTRQMVHIFASETNHFPPIKALFELVTSVTLTIFQQGPR----DHPDIVDSFMQLQAQALKRKPDLFLSENLDVKAVFHCGVLSLKFPEAPTVKSTCLFFSELIPH----CADIPPLARVVQEDGKLLLVAVLEAIGGQSSRSLMDQFAEVLFCLNKHCFTLLTVWLKEALRSPGFPSSRVSDEQKNTFSQQVLRERVNKRRVKDIVKEFTLVCRGLHGTEYAADY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "X1WB88-1", "uniprot_id": "X1WB88_DANRE", "id": "X1WB88-1", "name": "Importin-13", "aln": "---------------MTAEEFTVEAVERALQQLYYDPDMGKKNVAQKWLSEAQASPQAWQFCWDLLRPEKVPE-IQFFGASTLHAKISR--------HWSELPAGQLDSLRSQLMAQVGQFAAGPKMVLTRLCVALASLILHILPE-------------TWPTAVPDILCAFQTGEG---DGPSRCLALLELLAVLPEELQSSRIVTSRRSQ----------------------LRSALAAHWSSVCRLLQQLLQQPDAPGRVRERVLRCVSSWIT-LDVCLQDSEGILESCFTLLK-----------------ESEIFDAAVETIVCIISQPDCQRFVDSLLKVVPQVLALQEQLKKAVQDGDMETSHGICRIAVALG---ETHCRTLLEQVDHWQGFQALVS--------------------------MIMSCTATPGHYPVDETSSSLTLTFWYTLQDDITSLDAERQ-TLYLQIYRPLYFQLVDVLLQKACFPRDEDFTAWSAD--DKEQFRTYRVDISDTLMYTYELLG-PELLRNLYDKLGTLLTNST------HPSSWQDVETLLFGFQSIAETVDVSYSDVIPGLIGLIPLITAN---------------------NIQLAETIMFTIGSLAEWLSDHSPMLANVLPVVLQ---------------GLSNPDLSVACVSALKRICRECRHDLHLHANDIIVVSQAVLVKDIHKSPQC-MWIMQALGFLLSALP---REEILGKLLSLVTPHIQQLEKLASEP-PSSANKLLIVHILGLLSNLFSTFDLNKQSERLE---VMRHVQTQPLDNNPVVVVLQQAFPLIQTVLN-KWLSDPEVVEAVCAVFEKSLKTLIHDFAPLVTQLCELIGQMFSAYPQASALDLTRQLVHIFACEKDLFSPITALLELITNITMSIFQLGSR----DHPDVVESFMQLHTQVLKRKADLYLSDHLDIKAVFYCGILSFKFPETPTLKATCLLFTELISH----YEDLPTVRDVLQEDGKLLLQTLLEAIGGQSPRSLAELLAEVLFSVSRNCPSLLTLWLRDALLPSGFPSSHLTAEHKEHFCQQILREQVSKRQMKDIVKEFALLSRGLQGTEYAANY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VEC5-1", "uniprot_id": "Q9VEC5_DROME", "id": "Q9VEC5-1", "name": "Importin-13", "aln": "-----------------MEPIDIARLEEAVVSFYRS-NSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQE-VQFFGAITLHSKLMK--------HWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLG--------------EWPGAIEEVINTFQNQRMPNVSADVQLWIMLEVLTAIPEEAQVIHTSVKRVVLRAEI-----------------AKRVQLVIHTVERYLKLQMNRVWDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERHSTLLLSGITSADPELSILVH---------------------RIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSD--DLECFRCYRQDISDTFMYCYDVLN-DYILEILAAMLDEAIADLQR-----HPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKL-------------------NVKLLGTALETMGSYCNWLMENPAYIPPAINLLVR---------------GLN-SSMSAQATLGLKELCRDCQLQLKPYADPLLNACHASLNTGRMKNSDS-VRLMFSIGKLMSLLR---PEEIPKYLDIIVSPCFEELQAICQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQATD-----------QPIVQPVLLVMQRTMPIFKRIAE-MWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQ----SRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQHLSEMAMKTRGLTEKFQ----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32767-1", "uniprot_id": "KA122_YEAST", "id": "P32767-1", "name": "Importin beta-like protein KAP122", "aln": "-------------------MSSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQLNTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQN-INADQLLLDSINCSLTYEQLSQFVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQAVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQN----LIDLMYQSTEGSDGYENAEKILTIFGNVFANDPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEEEGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTLSESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDALLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFR-KELTPQEFDFMFEKILLVYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVAVAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQ-RSDLNSYTDLLRALVAKFPIEAREWLVAVL-----PQICNNPAGHEKFINKLLITRGS-RAAGNVILQWWLDCTTLPNYQG----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : .:* . :: * . : * *.:::. *: * :::*** :* :: * . . : : * .::: : :: : . : * .: .: :. .. :: . : * : : . : .. *. :*: : . . . : : ::. : * : .: . . . . ... : : . . * : :: :: * * ::* * : ** *.* : : : :: :* : : * . .: ..: . : *. :* :** :.:*. : * :. : .. *: : :::: . . . : :: : . ::.: * :*: . :: :.. : : :.: :. .:.. :. :*. *: :* : :: : : . :: ::* ::. ** : : . .:: : * :* * ::: . :*: : : : : : . : .: .:* * . :.:. . : ::. .: . : :: . .:: : .* :: : : :. . : . . :. : * :: : :.:: . : : : * : : : ** : :::* .: : *: : * . : : :: : . * : : : : * ", "identical_positions": 59, "similar_positions": 269, "identity": "5.28%" }, { "cls_id": "homologset.agr.HGNC:16854", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CHG7-1", "uniprot_id": "RPGF2_MOUSE", "id": "Q8CHG7-1", "name": "Rap guanine nucleotide exchange factor 2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPLAA---PANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGTR------------------KGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKG----------FGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE----------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIG------------------------------------LEKVNKKSKANTVGGRNKLKKILDKTRISILP----QKPYNDIGIGQSQ---------DDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTP--------------------------------------------------DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCAN-LKKFEEVINQETFWVASEILRETNQLKRMK--IIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQP-PVIPLFPVIKKDLTFLHEGNDSKVDGLVN------FEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKK--------WRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPGDKKPVKSETSPVAPRAGPQQKVQPQ-QPLAQPQPPHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFS------------------DSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPG---QTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M386-1", "uniprot_id": "RPGF2_RAT", "id": "F1M386-1", "name": "Rap guanine nucleotide exchange factor 2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPLAA---PANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGTR------------------KGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRSMTLTKPSREAPLPFILLGGSEKG----------FGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE----------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIG------------------------------------LEKVNKKSKANTVGGRNKLKKILDKTRISILP----QKPYNDIGIGQSQ---------DDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTP--------------------------------------------------DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCAN-LKKFEEVINQETFWVASEILRETNQLKRMK--IIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQP-PVIPLFPVIKKDLTFLHEGNDSKVDGLVN------FEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKK--------WRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQ-QPLAPPQPSHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFS------------------DSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSTEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPG---QTPPAATASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y4G8-1", "uniprot_id": "RPGF2_HUMAN", "id": "Q9Y4G8-1", "name": "Rap guanine nucleotide exchange factor 2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPLAI---PANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGTR------------------KGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKG----------FGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE----------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIG------------------------------------LEKVNKKSKANTVGGRNKLKKILDKTRISILP----QKPYNDIGIGQSQ---------DDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATP--------------------------------------------------DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCAN-LKRFEEVINQETFWVASEILRETNQLKRMK--IIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQP-PIIPLFPVIKKDLTFLHEGNDSKVDGLVN------FEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKK--------WRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFS------------------DSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z2S8-1", "uniprot_id": "A0A8M6Z2S8_DANRE", "id": "A0A8M6Z2S8-1", "name": "Rap guanine nucleotide exchange factor 2", "aln": "-----MASYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTECVKAQLPADFSRLHLADGIHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEPGDMDLSGLPETAVDSEEDDDEEDIERASDPLMSRDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGTR------------------KGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH--------DPSLRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAPLAFTLLGGSEKG----------FRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQ------------EQEQEEEPDRKNGAPHIPKIGDIKKASRYSIPDLAVDVEQVMD------------------------------------LEKASKKAKANSAGGRNKLKKIFDKTLTSILP----PKPYNDVGVGQSQ---------DDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQP--------------------------------------------------DMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEAYSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKLKTRLTGPPSLKLFEEAINRETFWVATEVVREANQLKRMK--IVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQP-PIIPLFPVIKKDLTFLHEGNDSKVDGLVN------FEKLRMIAKEIRHVGRMAAVNMDPALMFRTRKKK--------WRSLGSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLTLETNEESLQTLSMQCEPSINTLPKSSGDRK--RPDTSPVVSRAATHQRQQLQ-----------KANQALQVPAVALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSEEAG-DRHRKQAEDSVSNNSSQLSSPPTSPHSSPKKAIASIRSHGMKGFSSLCSKSPTGYGRAGDYLSDSGHSEISSRSSLVSTSSLDMG----QDERRQRYGGTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDCRGLYAGATVLSSPSSEELTQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEALAEG----------AGLWGS----------------------RGSWASACSSS---SSVACWGEDSEGDTGTIKRRGGRDVTTDPETSSITSTGSEESRQHSR-RPSPITAGNTKASITRKDGRYRDPPPTPPGYTALTITDVTEGTPHSGRKPPDYTTALQRSRLVTHSLDS-------QQPPAAGKPDPRGR-EEDEAVEVEEEGECLSPKLRAQRRRGPHTAVPPRP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2BIN3-1", "uniprot_id": "A0A8M2BIN3_DANRE", "id": "A0A8M2BIN3-1", "name": "Rap guanine nucleotide exchange factor 2", "aln": "MHADRMASYVDNSFRHAIMKIPADRTQQDLQIVYSYLHGMEALSNLREHQLRLMCETVRYEQHDANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEASEMIVVDYMDDNDEYFQRQASHRQSRRRFRKINQRGERQTIIDTVDNYPVSKPPLPPGYHSECPKSQLPTDFSKLHPSDSCH---SHMTSSQSRSSIASDSGSSSLSDIYQATESECGDMDLSGLPETAVDSDEDDDDEDVGRGTDHLMSRDIVRDCLEKDPMDRTDDDIEQLLEFVQQLPAFASLSVSVRRELCAVMVFAVVERAGTIVLNHGEELDSWSVILNGAVEVIYLDGRSESVCMGGSFGVCPSMEKQLMTGVMRTKVDDCQFVCIAQQDYCCILNQVEQNTQRVEEE-GEIVMVKEHRELDRTGTR------------------KGHIVVKGTAERLMQHLVEDHSIVDPTYIEDFLLTYRTFLPSPLILGQRLLDWFN--------DPCLRDKVTRVVLLWVNNHFSDFEGDPDMTSFLEEFQSNLEREKMTGQLRLLNIACAAKAKPRVITVTRTAREIPLPFTLIGGAERG----------TRLFISSVEVGSKAEEAGLKRGDQILEVNGQTFENVQLSKATEILRNNIQLSMSVKTNLLVFKELVARVAEE----------------------RKNGVPHLPKIGDGKKNCRYSIPELGAG-SDVIG------------------------------------QEKISKKAKAHTVGGRNKLMKILDKTRMSILP----QKPYSDLGLGQTQ---------DDSIVGLRQNKQTPPTMPVSGTLSSSNPDLAQGQQRIIDYSTQPPAPGF--------------------------------------------TQLQDQVLRIFKADQQSRYLLANRDTTAREAANLAIKEFGLSASPEAFSLCEVSVTQEGVIKQRRLPDQLSKLADRIQLSARYYLKSNMETETLCSDVEALEMQRESVVPLLSLSSMEIANQLSARNYLLFSCIEPTDYINDLFKLHPQEPPTN-LRNFEGLVNQETFWVATEIVQETNLAKRVK--IIKHFIKIALHCRDCKNFNSMFAIISGFNLAPVSRLRSTWERLPGKYEKLLAELQDVFDPSRNMAKYRNLLNKHNLQP-PVIPLFPVIKKDLTFLHEGNNSEVDGLVN------FEKLRMIAREIRHVVRMASITMDPALLFKTRKKK--------WRSLGSLSQVSS-SSLSDIGTMGGKRK-GRRSSFLSAKKLYEVEMMSRRVRQYLDTHSNECNEDTLHELSMTCEPANSSTLKHAGERR--RIDASPAGQRSASPQQTNGN-------------------------HGRKKSISKELPFEGR------------------DRQRKLPEDSQSSTSSLLSSPRNSPQSTPRKGPQLVVS------------------------------EVSDQMSLLSSSSSELLMVDDHTHT-QPHSLAHPLS-------ARR--AEPDQLSLGSYS----------------------LTQDQCDRASLDAADSGRGSWTSCSSGSHDNIQSIPQR-------------------VGYYDS--------------------RSWEMLSDGMGRSHMTTPTGYWADELEGDTGTIKRRGGKDE----------------------------TPNTNKNTVSRREGHFREPPPTPPGYTAVSLAEADTNSHAHGRRPPDYSAALQRSRFLKRTCDP---------PPLHSSSRLPPYSHCQTPRRS---------------QADESEQISAV-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VMF3-1", "uniprot_id": "Q9VMF3_DROME", "id": "Q9VMF3-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------MDPYHHIRHHYPPTSIAGTGVVVGSSTTINRPELHQKCNRGSHSSDTSSAYSGSDTMASN---------YASSLEAEEIDLSGLVESVVDS----DEEDLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSR-YGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMK--IVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLIN------FEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGG----------------------------GGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGP--------------------------------KFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTP-SPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLSLESSS------------------------------------------VTTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEPSPPVYTAADCRLLQQISNNAVTRNLNSPCQSTNTPPSTPTPPPNQPTATIQLSAPPTAAAYMHARSQHQQLQQQQQSLAMPPPPPPPYN---VPPLGSIYSHHQGTAGSRHLNHMHGKTTGPQERWFPDCRPTTKQQMQSGS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P07866-1", "uniprot_id": "LTE1_YEAST", "id": "P07866-1", "name": "Guanine nucleotide exchange factor LTE1", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------MEIFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIELNEPDKLDFDAWLHYSLKDFTQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPDNTSNVYSKHRIAKEPSVD-------------------NESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILN----------------SLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIKPANQKP---------EMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVN------------------------VDCERREHIHDIKILQQNSFKPSNDNFSAMDN----------------------------------LDLYQTVSSIAQSVISLTNTLNKQLQNNESNMQP----SPSYDALQRRKVKS-------LTTAYYNKMHGSYSAESMRLFDKDNSSSRTDENGPQRLLFHETDK--------------------------------------------------TNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLNLREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDNSLDASSEANNYDITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIAITPTKELSIVDPEQNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTVISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSRDLPVPHQRIINLREEYQRGNQDIISNTSS--------LHELKTIDLSDSNNDLESPSTHAKNNKYFFSPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANSESAFTGSLNKKNLNEIAN----------------------MLDDSINDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIP-----------------------FTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAIS----------------------------------------------RFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNK---FDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELST-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . : . * . . : .. : : ....: * * :. :. ::. : : : : : :..: : * *.. .: :.. ::** : : . :. :. : . :. . . : : . .:.. :.: : :.. . : .: * ... .. . .:: :* : : *: :: * .:: :. : : :*:: ::. : : : . :. : : . .:.: : : . : ::. * *. . *. :: .... .: :: : : . :*. : :: ..: :: . . .: . . .. . *. : . .: * . : : : : . : . . : .. .* . .. *: . : : .: : ::. : . ::* . . : . . : .. : : : : :: . . . .*:. : : . : . : : : .... :.* *:: .. . *:: :. ::: : .: **:: :* : : : : . : . ..:::.::* . : . : . :. :: .:: . : ::.: . **. * :. : : .: : . .. : : . : : . .: . . . : . :*.. .: ::: .: : . : . : : .. . .: . . .. . : : . : . . . * : . : : . . . : . ::. . ", "identical_positions": 35, "similar_positions": 347, "identity": "1.88%" }, { "cls_id": "homologset.agr.HGNC:16855", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LU55-1", "uniprot_id": "A0ABK0LU55_RAT", "id": "A0ABK0LU55-1", "name": "", "aln": "MAFR----RRT--KSYPLFSQEFVIHNHADIVFFLVLCVLIGLMFEVTAKIAFLCILPQYNVSVPTADSETVN-----YHYGPKDLATILFYILITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHLSSVAWCLYVVATEGYLSNPRSLWEDYPHVYLSLGSALPLHLSKSPGAVPGHTKNSLISSFQVKFFYLGQLAYWLHALPELYFQKVR-KEEIPRQLQYICLYLLHIAGAYLLNLSRLGLILLLLQYSTEALFHMARLFYFAD--ENNERLFNAWAAVFGVTRLFIFTLAVLTIGFGLARVENQVFDPEKGNFNTLPCRLGMLLLVCVAQAWLMWRFIHSQLRHWREYWKEQSAKRRVSAVPRLPARLLKREPGFHENGVVKTENGTSSRTKKLKSP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q924Z5-1", "uniprot_id": "TRAM2_MOUSE", "id": "Q924Z5-1", "name": "Translocating chain-associated membrane protein 2", "aln": "MAFR----RRT--KSYPLFSQEFIIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVH-----YHYGPKDLVTILFYVVITIIFHAVVQEYILDKISKRLHLSKVKHSKFNESGQLLVFHLSAVAWCFYVIVTEGYLTNPRSLWEDYPHVYLS---------------------------FQVKFFYLGQLAYWLHSLPELYFQKVR-KEEVPRQLQYICLYLLHITGAYLLNLSRLGLILLLLQYSTEALFHMARLFHFAD--ENNERLFNAWAAVFGVTRLFILTLAVLTIGFGLARVENQVFDPEKGNFNTLPCRLGMLLLVCVAQAWLMWRFIHSQLRHWREYWKEQSAKRRVSAVPRPPAKLLKREPGYHENGVVKAENGTSSRTKKLKSP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15035-1", "uniprot_id": "TRAM2_HUMAN", "id": "Q15035-1", "name": "Translocating chain-associated membrane protein 2", "aln": "MAFR----RRT--KSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVH-----YHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLP---------------------------FQVKFFYLCQLAYWLHALPELYFQKVR-KEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFAD--ENNEKLFSAWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHENGVVKAENGTSPRTKKLKSP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W5C2-1", "uniprot_id": "Q9W5C2_DROME", "id": "Q9W5C2-1", "name": "Translocating chain-associated membrane protein", "aln": "MAIKPGLGRKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGEDPSREQPYGKPYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQLVAFYLLSFVWGAHVLLKEGYLGQVAQLWEGFPDHPMS---------------------------FLHKFYFVVQLAYYLHMLPELYFQKIKTKEEQQPKIVHSISGFTLIVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLRVVNNAVFFLIRFATSVIGVLTLYYGIGGVR----------------SLLALGGLIALQGYLVFSFITEQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKKESDLPEADQTSPSPIKQKLK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:: *:* *. *::*:**:*:***** :.: .::*** * ** * * ::*:* .. * * * ** :*:** . **:**::**::******:*****.* ::*******:.*:: :. * :*: .**** : .***.:*. :. * **::: ****:** ********:: *** :: : : *. ** *.:.**.*:** *:* :* * * :*: . * *. :* . *** : *: .:.**:: :*:. :. * * : . *.:*:: ** .*** ** :* . : ::. .: **: * : :::. : : **. . * * ", "identical_positions": 133, "similar_positions": 109, "identity": "32.36%" }, { "cls_id": "homologset.agr.HGNC:16856", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZDT7-1", "uniprot_id": "D3ZDT7_RAT", "id": "D3ZDT7-1", "name": "separase", "aln": "--MRNFKGVKFATLLCCKRETQELLPDLKEFLSRSRTDSVSSRTDAERRQVCDTILRACTQQLTAKLDGPGHLRSILDLAELACDGYLLSTP---QRPPLYLERILFILLRNGLTQGNPDAVLRLAQPLHACLVQNSREAAPQDYEAVTRGTFSLLWKGAEALSERRAAFSARLKALSFLVLLEDGSLPCEVPHFASP--TACRVVAAYQLFDATGQGLDAADADFVYDLLSRHVIRVLVGEGGRASGPLSPQRALCLLELTLEHCRRLCWNQHHHKATIAVEKTRDHLG-NSNVAPSLQLCQMGVELLEAVEERPGAVAQLLMKAAAILNSSMDGPSPPLRALYDSCQFFLSGLERTIKRHYGVDAILNLFAFLGGYHSLVRHLR--EASEASSKQQQSLLQMHFHTLHLFTGIVYDFAQGCQVAELA---QLVDSCRSAVVWMLEALEGLSGGELADYLGVTASYTSNLAYSFFSQKLYEEACAISEPVCQHLGLAKSGACPEVPPEKLHRCFRLHVESLKKWGKQAQGCKMVTLWLAALKPYGLQHMVEP-VTFWVRVKMDAAKAGDKELQLQTLRDSL--SCWDPEMQSLLLREELQAYKAVRADTGQERFNVICDLLELSPEDTAAGAWARATHLVELAQVLCYHSFAQQTNCSALDAIQEALQLLESVSPEAQEQDRLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPS-------NLEEFEVNDLNYEDKLQ--EDRFLYSNIAFNLAADAAQSRCLDQALTLWKEVLTKEPAPAVRCLQQTAASLQILVAIYQLVAKPLQALETLLLLQIVSKRLQDHAKAVSSSCQLTQLLLNLGCPSYAQLYLEEAESSLKNLDQATDTCQLLSLTCALLRSQLCWACQKVTEGVSLLLSVLRDPALQKSSKAWYLLRVQALQILAFYLSLSSNLLSSALREELWDQGWQTPETALIDAHKLLRSIIILLMGGDVLSVQKAAVESPFLDYGENLVQKWQVLTEVLTCSERLVSRLGRLGNVSEAKAFCLEALKLTTKLQIPRQCALFLVLKGELELARGDTDLCQSDLQQVLFLLESSTEFGVVTQHPDSVKRVHTQKGTHKAQVPCSPPLPEEEPFLRGPALELVATVLKEPGPIQPSGNSSPVLKTKASPKPGFLSHLPSCDCLLCASPALSTVCLRWVLVTAGVRLTTGHKAQGLDLLQAVLKGCPAATKRFTQNLQTSLNHKAPPSCVPSLFDEIMAQVYTHLALECLNQTSE---KSLGKVLASGLKFVATR---IQYLEFWQASLL----LVQALAKLARFSCCTSELFASAWGWQPPLVKIPPV---------------------------LEPSKIRRQKCSGQGRQRVASAPSPLHSSSQEGLEE-GPPCTPKP---------------------------------------PGRARQAGPRVPFTIFEDIHPTKSKLKVPLAPRVHRRAQTRLKVNFSDDSDLEDLVSAETQLVEEPKRRGTASRTRGQSRKGPSLKTDAAVAVGSTP--GHPSLSGRTRRARKVASRHCEG--------VGASLGPEIMRSIPEEELMDSQLEKSFEILRASD--GEDSASGEKAAAAEPGLPIGEREVLRRDSSKAERPVLYPDT--EADSDLSPWLPPFSIPAPIDLSTLDSIADSLSIAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLVAESVSITCRHQLLTHLHRQLSKAQKQQGSPELAEHLQRLDLKERPGGVP---LARVQHLFSFRALGSGCFPQAEKDSFQKRLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITVKIPTAQSKFPLSAVLKEFDAIQKDQKENSGCTEKRAWWTGRLALDQRMEELITSLEEHVLGCWRGLLLPCSTDPGLSQEASQLQELLHECGWEYPDYTLLKVILSGARILSSQDVQALACGLCPAQPERAQVLLSEAVGRVQSQAAPPSQHLVLVLDKDLQKLPWESMPCLRALPVTRLPSLRFLLSYSIAKEAGASSVLSQG-VDPRNTFYVLNPHSNLSSTEERFRASFSSEAGWKGVIGEVPSLEQVQAALTEHDLYIYAGHGAGARFLDGQAVLRLNCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLG-------AGPGAPLLHYVSQARQAPRLKYLIGAAPVAYGLPVSLQTS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P60330-1", "uniprot_id": "ESPL1_MOUSE", "id": "P60330-1", "name": "Separin", "aln": "--MRNFKGVNFATLLCSKEETQQLLPDLKEFLSRSRTDFPSSRTDAERRQICDTILRACTQQLTAKLDCPGHLRSILDLAELACDGYLLSTP---QRPPLYLERILFILLRNGSTQGSPDTVLRLAQPLHACLVQNSGEAAPQDYEAVTRGSFSLFWKGAEALLERRAAFSTRLNALSFLVLLEDGSVPCEVPHFASP--TACRLVAAYQLYDATGQGLDEADADFLYEVLSRHLIRVLVGEGGSSPGPLSPQRALCLLEITLEHCRRLCWNHHHRQAARAVERARNHLE-KTSVAPSLQLCQMGVELLEAVEERPGAVAQLLRKAAAVLINSIEAPSPPLRALYDSCQFFLSGLERGIRRHCGLDAILSLFAFLGGYSSLVRHLR--EVSEASSKQQQCLLQMHFQGFHLFTGIVYDFAQGCQATELA---QLVDGCRSAAVWMLEALEGLSGGELADYLSMTASYTSNLAYSFFSQKLYEEACVISEPVCQHLGSATSGACPEVPPEKLHRCFRLHVESLKKLGKQAQGCKMVTLWLAALKPYSLEHMVEP-VTFWVRVKMDASRAGDKELQLQTLRDSL--SCWDPETQSLLLREELRAYKSVRADTGQERFNIICDLLELSPEETAAGAWARATYLVELAQVLCYHNFTQQTNCSALDAVQEALQLLESVSPEAQEQDRLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPS-------NLEEFEVNDLNYEDKLQ--EDRFLYSSIAFNLAADAAQSKCLDQALTLWKEVLTKGRAPAVRCLQQTAASLQILAAVYQLVAKPLQALETLLLLQIVSKRLQDHAKAASSSCQLTQLLLNLGCPSYAQLYLEEAESSLRSLDQTSDACQLLSLTCALLGSQLCWACQKVTAGVSLLLSVLRDPALQKSSKAWYLLRVQALQVLAFYLSLSSNLLSSALREQLWDQGWQTPETALIDAHKLLRSIIILLMGSDVLSIQKAATESPFLDYGENLVQKWQVLTEVLTCSERLVGRLGRLGNVSEAKAFCLEALKLTTKLQIPRQCALFLVLKGELELARGDIDLCQSDLQQVLFLLESSTEFGVVTQHPDSVKKVHTQKGKHKAQGPCFPPLSEEEPFLKGPALELVDTVLNEPGPIQSSVNSSPVLKTKPPPNPGFLSHLPSCDCLLCASPALSAVCLRWVLVTAGVRLATGHKAQGLDLLQAVLTRCPAATKRFTQSLQASLNHRTTPSCVPSLFDEIMAQVYTHLALEFLNQTSE---KSLGKVLASGLKFVATR---IQSLEIWRAHLL----LVQALAKLAHFSCCTSELFASSWGWHPPLVKSLPV---------------------------LEPAKIRRQKCSGRGRRRIASVPPPLHNSSQKGLEEEGPPCTPKP---------------------------------------PGRARQAGPRVPFTIFEEVHPTKSKLQVPLAPRVHRRAQTRLKVIFSDDSDLEDLVSADTQLVEEPKRRGTASRTRGQTRKGRSLKTDAVVAIESTP--GHSSVSGRTRRARKVASRNCEEESPKAPLCVWASQGPEIMRSIPEEEPVDNHLEKSFEILRGSD--GEDSASGEKAAAADTGLPVGECEVLRRDSSKAERPVLYSDT--EANSDPSPWLPPFSVPAPIDLSTLDSISDSLSIAFRGVSHCPPSGLYAHLCRFLALCLGHRDPYATAFLVAESISITCRHQLLTHLHRQLSKAQKQQESPELAEHLQRLDLKERPGGVP---LARIQRLFSFKALGSGCFPQAEKESFQERLALIPSGVTVCVLALATLQPGTLSNTLLLTRLEKDNPPITVKIPTAQNKLPLSAVLKEFDAIQKDQKENSSCTEKRVWWTGRLALDQRMEALITALEEQVLGCWRGLLLPCSADPSLAQEASKLQELLRECGWEYPDSTLLKVILSGARILTSQDVQALACGLCPAQPDRAQVLLSEAVGQVQSQEAPRSQHLVLVLDKDLQKLPWESTPILQAQPVTRLPSFRFLLSYTVTKEAGASSVLSQG-VDPQNTFYVLNPHSNLSSTEERFRASFSSETGWKGVIGEVPSLDQVQAALTERDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLG-------AGPGAPFLYYASQARQAPRLKYLIGAAPVAYGLPISLQTP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14674-1", "uniprot_id": "ESPL1_HUMAN", "id": "Q14674-1", "name": "Separin", "aln": "--MRSFKRVNFGTLLSSQKEAEELLPALKEFLSNPPAGFPSSRSDAERRQACDAILRACNQQLTAKLACPRHLGSLLELAELACDGYLVSTP---QRPPLYLERILFVLLRNAAAQGSPEATLRLAQPLHACLVQCSREAAPQDYEAVARGSFSLLWKGAEALLERRAAFAARLKALSFLVLLEDESTPCEVPHFASP--TACRAVAAHQLFDASGHGLNEADADFLDDLLSRHVIRALVGERGSSSGLLSPQRALCLLELTLEHCRRFCWSRHHDKAISAVEKAHSYLR-NTNLAPSLQLCQLGVKLLQVGEEGPQAVAKLLIKASAVLSKSMEAPSPPLRALYESCQFFLSGLERGTKRRYRLDAILSLFAFLGGYCSLLQQLRDDGVYGGSSKQQQSFLQMYFQGLHLYTVVVYDFAQGCQIVDLADLTQLVDSCKSTVVWMLEALEGLSGQELTDHMGMTASYTSNLAYSFYSHKLYAEACAISEPLCQHLGLVKPGTYPEVPPEKLHRCFRLQVESLKKLGKQAQGCKMVILWLAALQPCSPEHMAEP-VTFWVRVKMDAARAGDKELQLKTLRDSL--SGWDPETLALLLREELQAYKAVRADTGQERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQTNCSALDAIREALQLLDSVRPEAQARDQLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPG-------NLEEFEVNDLNYEDKLQ--EDRFLYSNIAFNLAADAAQSKCLDQALALWKELLTKGQAPAVRCLQQTAASLQILAALYQLVAKPMQALEVLLLLRIVSERLKDHSKAAGSSCHITQLLLTLGCPSYAQLHLEEAASSLKHLDQTTDTYLLLSLTCDLLRSQLYWTHQKVTKGVSLLLSVLRDPALQKSSKAWYLLRVQVLQLVAAYLSLPSNNLSHSLWEQLCAQGWQTPEIALIDSHKLLRSIILLLMGSDILSTQKAAVETSFLDYGENLVQKWQVLSEVLSCSEKLVCHLGRLGSVSEAKAFCLEALKLTTKLQIPRQCALFLVLKGELELARNDIDLCQSDLQQVLFLLESCTEFGGVTQHLDSVKKVHLQKGKQQAQVPCPPQLPEEELFLRGPALELVATVAKEPGPIAPSTNSSPVLKTKPQPIPNFLSHSPTCDCSLCASPVLTAVCLRWVLVTAGVRLAMGHQAQGLDLLQVVLKGCPEAAERLTQALQASLNHKTPPSLVPSLLDEILAQAYTLLALEGLNQPSN---ESLQKVLQSGLKFVAAR---IPHLEPWRASLL----LIWALTKLGGLSCCTTQLFASSWGWQPPLIKSVPG---------------------------SEPSKTQGQKRSGRGRQKLASAPLRLNNTSQKGLEGRGLPCTPKP---------------------------------------PDRIRQAGPHVPFTVFEEVCPTESKPEVPQAPRVQQRVQTRLKVNFSDDSDLEDPVSAEAWLAEEPKRRGTASRGRGRARKGLSLKTDAVVAPGSAP--GNPGLNGRSRRAKKVASRHCEERRPQR-ASDQARPGPEIMRTIPEEELTDNWRKMSFEILRGSD--GEDSASGGKTPAPGPEAASGEWELLRLDSSKKKLPSPCPDK--ESDKDLGPRLRLPSAPVATGLSTLDSICDSLSVAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLVTESVSITCRHQLLTHLHRQLSKAQKHRGSLEIADQLQGLSLQEMPGDVP---LARIQRLFSFRALESGHFPQPEKESFQERLALIPSGVTVCVLALATLQPGTVGNTLLLTRLEKDSPPVSVQIPTGQNKLHLRSVLNEFDAIQKAQKENSSCTDKREWWTGRLALDHRMEVLIASLEKSVLGCWKGLLLPSSEEPGPAQEASRLQELLQDCGWKYPDRTLLKIMLSGAGALTPQDIQALAYGLCPTQPERAQELLNEAVGRLQGLTVPSNSHLVLVLDKDLQKLPWESMPSLQALPVTRLPSFRFLLSYSIIKEYGASPVLSQG-VDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVGEVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLG-------AGPGAPLLYYVNQARQAPRLKYLIGAAPIAYGLPVSLR--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PRZ2-1", "uniprot_id": "A0A8M9PRZ2_DANRE", "id": "A0A8M9PRZ2-1", "name": "separase", "aln": "MALKSLKTEDYVQQLSCVKDTIVLHNELKKHVDGGLGPYG--------RTMCDRIIRACNQRLGNGAVDAGLQERIVELVELAVQGFQLLEESGMQSTPFYLEKIVFHILQKVASLGAHGPACRLGQLVYRRLKCLS--AEIDDFNVLVRNCFAVLWNSLLSNKPSASTLPPRDRLHCQLQALTFRLLEQGSSSSSSPSKVPLFVEEAVVEYERSCGGFTQDDVSFLTSELRELFSGAFINPQDSAS---TSSLLAVWCEVAFKVSKLLCKSSFSPEAVELLRGTLKEVNGHVGLRSALGLADRAVQMQCVLSSGGECSKSFTECARALRMLPCAMSSSESHALLEACQLVVWTLEASQCKGMDVTTLLACFSFLEEYQEFLLAQQ----KNSFSLQVQYSLCFSFYQGFICT---YDSLHASQVSVGETLDRVLLFCRSTAGRMLAELRTLNND---NLLLKAVCAVNNVVYELFNRKLYEGAFGLSMIVCQELCKDCP---PSLPMDRVNRCFMLTVQCSRRAGHLEQALDWIVRWIQALGSQILDHLTEP-VSMWVKTKCDAARAGEDDTRLRTLRDGLGESLVDEEVMMCLLEEELRVYKEQTGDTAQERYNTLCDLLEICHEETPH-TLRRATYLCEMAQVVCYQDFSQQTDCSAVDFTHEALRLLEAEPETAENTDRLKDEKAHASLWLYICTLESNLQEAVDTEKRLCAVQEENKRDVNMDPVPTNDLEYEDKQKSQESQLVYDGLRFNLLAHSKQSEPLDKCLSLWRSLLKG-AVPAVRDPKLTASSMTLMAALYTLMGKHLQALEGYQLAATLFHVLGDGQSSANAFCHSTRILLYLGSPQLAQVDLEKAEKSLSSVTIS-EGTSIISMLAMLQKAQLHYALGQVESGVSCLMEVIKESAQHHS-KSWYLLRARALQTASEYLSLDTLALNSQLRQSIMQQGLKTPDTAQYEGLKLLCSLVMMLLGNGFYGAPGPNTDTRFVDKGDSVVFKWLLLSEVLVCSERMVITRSSSGAVHEAKAQCLEALKLATKLQTLSHCAELLVLKAELELMKGATEASSLDLEQVRHLLDLCTDFGQGRQQ-KSEVKIKPRKGRPAAPSSSGHISEEEDDLSGILSSRALPKEPVENMARLGSQGASPPLKPKCQHGLSCLTHEETCSCLCCTELSVARVSIHWALLQADLQTDP---ERSLRLRQSARKRCRYVVTKLQRSLAALVHSKKSPNVCLSLLQAEQGKVHLGAVLQLLRTGDKGKAAILWEEIEAGLEAVTPKGALTPELGPIRATLLGAKAVACCLALAMKKQCIPEELFSSLWHWNPPKVKPQLKSKHRSKSPDAAPLEAGVKHNPKVKSGLEENESRKTKETTVISKKAKDSVPKITITKSSMVFKTPKATRTTRPKSVSTSTGISDLRAFDFNNEVPDISVNFTPSLHRSTNQSATAKSKASSKGSFQVYKDSSPAAEK-AVVVPAAPKRTKRSRFKVEFSDESDNDAAPLAVMEKSEKKKNTFKTSRTLKPTLNTIPSDTKLVSSTVDPEPSRRTRTTKKSTALPSIGGLSSEEELGVSSQTRTRRGRPKKSTSSADTEEPERMRMIKEEEQRVLLNVSMEELRGSDTETKDTGSPDADCEVLRRDLGADFGRECFSELRRAGQNGSGSHTALPHATTSPADLSVETVQSYLRSSWLLLHHFPFPSLYPHICSLLAQSFGQTDPIITAMLHAQALGVSTRHHMTRHVVNQFRKLKKSCN--DVAEGLGALSLEETSGATQSKKLSALEQIFSFTASNPMQFPQTHCQQFTQQLEDLPAGVTVCLLSLTGVHPDEIGNTILLTRLERGSTPITVRIPTADREQSVAGLLEEMDGVLKGQKEVSTVAEKSQWWDGRKALDARVEKMLEEMEEALG-VWRTLFLPLTSDPKLDVQVKSLQKALKST---KITRDTLKVILSASPLLSLPDLQCLLEGMN-VQDKDLLKLLQRGVAELRGREEPQG-HTVLILDKYLQRLPWENIACLKSQSVTRMPSLHAVLGHSHLREVDTSCVLSCG-VNPKQVYYVLNPDGNLPDTENRFKEWFTGERTWQGVCGRAPDPEKLQEAVTTKDLYIYIGHGAGARFLDAQRVLKVPVRTAALLFGCSSAALSVLGQQEGTGIILSYLTAGCPLVLGNLWDVTDRDLDRFTSALLQSWLS-------AGSGSSLLQHLAKSRSATHLKHIIGAAPIAYGLPVHIH--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VRN6-1", "uniprot_id": "Q9VRN6_DROME", "id": "Q9VRN6-1", "name": "separase", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLETGDEAEMLAGFTSSDVGPEAKEYNLLRADEEYRNGNVEH------------------SIYYQVKAQFQSTDLRYLTESAELENQRPTAEELIKSATKLEKKDYKSKKFLQNIIKYLQQMEQEKQPKKPIN--------EIPEYLDFLDDVQDPTEGLTRISEKCN-----------------------------------------------SLPQEWCVLQLCKSFN-------------------------------------------------------PATTYSVFNEIIASDGAIYLTLLR-----HCRSSQLGPICLKISNENT----------------ANLFREYSTLVERFRRVVTVDPLNMKGKEAKQKYWEELNG-----------------------------------------------------------------FDTFQQKLLADFRDIISPYSFLFFG---------------------------------KRYDCTVVQKQIKATYTRVDD---------------------------------------------------------------------FCLLNQWGTHQRVLLSQAASHANRLEIADLKLICYELSSNENEIQSAYELLKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------LASDWAEVEERQPLASRRFPIILVVDERLDHLHWEQLVTVQEFSRVKSLHCLWRLFQNHKSNIKHGYYTTNIKRGMCVINPDADLVNSG----RRLRSFFEYWLS-----------QWQHLFETVPN-------EEVMVKQALQADCFVYAGHGSGLQYVNGRIICRARVRSVVFLFGCDSTRMLGTGLYSALYGAHDYYHG--------------------------------------------------------------------ALCPSIVGTLMPALDGNMDTVSVTILSRWLAPGDNK---------VIPWTHIDRVPWLKNGIIKGKDET-TPTMNDQPNYHLGSLCSILSLVQQGKVEPNIYNCCIYVCRGLP--------------AWNLAVEKLPL-------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03018-1", "uniprot_id": "ESP1_YEAST", "id": "Q03018-1", "name": "Separin", "aln": "------------------------------------------------------------------------------MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIEDITTVDHSLNSIYSLLKSHHMWGHINST--------------VKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKLPFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFN----------------------------EYCNMSENRLLWSCISVDDLN----------VILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDESAAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQSAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSRMIFCSLRGIFDLDPLELNNTFDKLHLLN-----------------------------KYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMDFVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLHASSLINVHLWDSDLTAFQIYFG------KTLPAMKPELFDINNDHNLPMSLYIKVILLNIKIFNESAKLNIKAGNVISAVIDCRKAQNLALSLLKKKNKLSQGSRLALLKSLSFSFFQLIKIHIRIGSARDCEFYSKELSRIISDLEEPIIVYRCLHFLHRYYMITEQTCLQNITLGKANKAFDYLDAEADITSLTMFLYDNKEFVKLEQS---------LVLYFGDQLEKTFLPNLWKLHLGKDIDDSICLSEYMPKNVINRVHNMWQKVMSQLEEDPFFKGMFESTLGIPSSLPVIPSTMPNNILKTPSKHSTGLKLCDSPRSSSMTPRGKNIRQKFDRIAAISKLKQMKELLESLKLDTLDN---------------------------------------------------------HELSKISSLSSLTLTILSNITSIHNAESSLITN-----------------------------------FSLTDLPRHMPLLFDKVLNN------------------------------------------------------------------IDNKNYREFRVSSLIAPNNISTITESIRVSAAQKDLMESNLNINVITIDFCPITG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLLSKLEPRRKRRTHLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQTTSVEVTNKIKTREERKSWWTTRYDLDKRMQQLLNNIENSWFN-----GVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPS-------------RKLYGNPAMFIKVEDWVIELFLKLNPQE-----IDFLSKMEDLIYFVLDILLFHGEE------------------------------------------------------------------------NAYDEIDFSMLHVQLEEQIKKYRATMTTNSIFH-----------TFLVVSSSCHLFPWECLSFLKDLSITRVPSYVCLNKLLSRFHYQLPLQVTIEDNISMILNPNGDLSRTESKFKGMFQKIIDAKPSSQLVMNEKPEEETLLKMLQNSNLFVYIGHGGGEQYVRSKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEELFEKMGFRCNTDDLNGNSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLPIKFVS-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . : : . : :. *:. . . . * : * . * .: . .* ..* :. . : : : :: : : . :::. . . : :: .: .. . : : : . * . : . : . : . : . . :: : : . :. :*. : :* .: : : :: .: . . * : : . : :: . . .** :: * *: : . . . . . * ", "identical_positions": 16, "similar_positions": 98, "identity": "0.72%" }, { "cls_id": "homologset.agr.HGNC:16857", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P58334-1", "uniprot_id": "KLF16_MOUSE", "id": "P58334-1", "name": "Krueppel-like factor 16", "aln": "MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRATRREATPPGTPGAPPPPATAPGPG-GATAAPHLLAASILADLRGGPVVATAASTAGGTSPVSSSSAASSPSSGRAPG-----AAKSHRCPFHGCAKAYYKSSHLKSHLRTHTGERPFACDWPGCDKKFARSDELARHHRTHTGEKRFPCPLCTKRFTRSDHLTKHARRHPGFRPELLRRPGARSVSPSDSLPCSLAGSPTPSPVPSPAPAGL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B2GUY9-1", "uniprot_id": "B2GUY9_RAT", "id": "B2GUY9-1", "name": "", "aln": "MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRATRREATPPGTPGAPPPPATAPGSG-GATAAPHLLAASILADLRGGPGVATAANTAGGTSPVSSSSAASSPSSGRAPG-----AAKSHRCPFPGCAKAYYKSSHLKSHLRTHTGERPFACDWPGCDKKFARSDELARHHRTHTGEKRFPCPLCTKRFTRSDHLTKHARRHPGFRPELLRRPGARSASPSDSLPCSLAGSPTPSPVPSPAPAGL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXK1-1", "uniprot_id": "KLF16_HUMAN", "id": "Q9BXK1-1", "name": "Krueppel-like factor 16", "aln": "MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVRAARREAASPGTPGPPPPPPAASGPGPGAAAAPHLLAASILADLRGGPGAAP-----GGASPASSSSAASSPSSGRAPGAAPSAAAKSHRCPFPDCAKAYYKSSHLKSHLRTHTGERPFACDWQGCDKKFARSDELARHHRTHTGEKRFSCPLCSKRFTRSDHLAKHARRHPGFHPDLLRRPGARSTSPSDSLPCSLAGSPAPSPAPSPAPAGL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********************************************:****:.*****.****.:*.*.* **:****************** .*. **:**.**************** ********* .**************************** *************************.****:*********:*********:*:*********.**************:***.********", "identical_positions": 221, "similar_positions": 22, "identity": "85.99%" }, { "cls_id": "homologset.agr.HGNC:16858", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZL57-1", "uniprot_id": "D3ZL57_RAT", "id": "D3ZL57-1", "name": "USP6 N-terminal-like protein", "aln": "------------------------MNSDQDVALKLAQERAEIVAKYDRGRE-GAEIEPWEDADYLVYKVTDRFGFLHEEELPYPNAAADRQK-QLEIERTSKWLKMLKRWERYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERILTAMSYTILKLHRKHLMKLS-MEELVEFLQETLAKDFFFEDDFVIEQLQVSMTELKRAKLDLPEPGKEDEYPRKPLGQLPP-------EYTNHLSNGQRSVGRPSPKISSRREDGSPHKAHEHSPAHHSRNGTPERVGQSRR-KSVDEGSKNLKQEADFQRKPSSGTQD--NSKHYNHATANQNSNALSNIRKEFVPKWRKPSEASAIERTAKYAIEG-RSHSVFPALSVAVPSSAETRLSNSRQKMKAFDGGEGNRGSNASQYDNVPGSESEPGASAEEGPERTH---------PHSPRKHSEPSPSPSKVPNKFTFKVQPPSHVRYPSQPAGEDHRAAYPPSYSNPPVYHGNSPKHIPTAHSGFASTQISLGPQVNPSRRPYGSSLSGDTSPEKSYGRLTP-VLPSSRIEVLPIDIGARGY-GSSGSPKSGKFILPPVDYLPENRKWSEFSYTYRPEVHGQSWTQDATRS---HLSNLPKYTAFP------HIPLQDHGLPEVSVDSPVRYKTSPAVEEASPPGYPYAGPTPSAHHYRNREGLSVQESVLL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80XC3-1", "uniprot_id": "US6NL_MOUSE", "id": "Q80XC3-1", "name": "USP6 N-terminal-like protein", "aln": "------------------------MNSDQDVALKLAQERAEIVAKYDRGRE-GAEIEPWEDADYLVYKVTDRFGFLHEEELPYHNAAADRQK-QLEIERTSKWLKMLKKWERYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLS-MEELVEFLQETLAKDFFFEDDFVIEQLQVSMAELKRAKLDLPEPGKEDEYPKKPLGQLPPE-----SACVNHLSNGQRSVGRPSPKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRR-KSVDEGSKNLKHEAESQRKPSPGMQD--SSRHYNHAAANQNSNAISNVRKEFMPKWRKPSDASAIERTTKYAVEG-KSHSALPALPVAIPGSAETRLPNSRQKMKALDGGEGKRGSNASQYDNVPGGESEHGASAEEGPERTH---------PHSPRKHPEPSPSPPKVPNKFTFKVQPPSHVRYPPQLPEEDHRAAYPPSYSNPPVYHGNSPKHVPTAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEKAYSRPTPVVLPSSRIEVLPIDMGARGY-GSSGSPKNGQFILPPVDYLPENRKWSEVSYTYRPEMHGQSWTRDAHRS---HLSNLPNYAAFQ------HIPFQAHGLPEVSVDSPVRYKMSAAVEDASPPGYPYAGPSPSAHHYRNGEGLSVQESVLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92738-1", "uniprot_id": "US6NL_HUMAN", "id": "Q92738-1", "name": "USP6 N-terminal-like protein", "aln": "------------------------MNSDQDVALKLAQERAEIVAKYDRGRE-GAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQK-HLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLS-MEELVEFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLGQLPPEL---QSWGVHHLSNGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSRTGTPERAQPPRR-KSVEEESKKLKDEADFQRKLPSGPQD--SSRQYNHAAANQNSNATSNIRKEFVPKWNKPSDVSATERTAKYTMEG-KGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAEDGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSNKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFASPQFSPGTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNGKLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASR------GNLPKYSAFQ------LAPFQDHGLPAVSVDSPVRYKASPAAEDASPSGYPYSGPPPPAYHYRNRDGLSIQESVLL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BC35-1", "uniprot_id": "A0A8M2BC35_DANRE", "id": "A0A8M2BC35-1", "name": "USP6 N-terminal-like protein", "aln": "MQVLQIVKELVSPSRRRAGSRFTASDSEQDAAVKLEQERAEILAKYDKGKE-KAEVEPWEETNFELYKAVDRFGFLHEGELVYD-IVEEKQK-QLEVERTTKWLKMLKSWEKYKNSDKLVRRIYKGIPLQLRGQVWCLLLDIPKIKEEKKDFYEKLKIRARGLSPDVRQIDLDVNRTYRNHIMFMHRYDVKQQDLFHVLTAYSVYNTEVGYCQGMSQITALLLIYMNEEDAFWALVKLLSGQRHTMHGFFVPGFPKLMRFQEHHDRILQKMMPKLKQHLDNQEVYTSLYTMKWFFQCFLDRTPFTLTLRIWDIYILEGERVLTAMSYTILKLHKKTLLKLS-MEELVKFLQVTLSNDFFFEDDFVIEQLQNSMSELRRSKLELPPPGKEDEYPKKPLGQLPPEPPGLAAAATNHVANGQ-PVGQTGEGLPPRGPSPAVSVNKRVDSGP-VTDGTPERYQDSRPPSSLDKFHHPDKIERDGRGVYANKERVPVGGKASTQNQANHNSNARSSMRREIGPRWVKPSEGKLEAVKAAALRESQLSLATGVPPSPSSPTPDEATGAQRRPRSRAFAPG-SNRASNASQYDNVPGPDGEVMEIIELEKPPSRPPSRP---FVGPPLRQGSPTRPPSGGTGVSPFRVPKQSMMQSKPEPRAP---LHYPPGMT--PVYTPYISETRQEER--LYSQSYTEQIYATTGRG------SSNPSPEKTVMNNSYLTYRRPPPDMPPLRVAPAELSSQIDSAGEGVYYLRQPTRLIGSPAYPPTELRYEGNRRREGWYGDVEAGPPRSPAGVPRSPSFQKAQLSPVHPVQEFNFAQANISDAVLHFRGPYQEHSGRQQLPP--LFGGAHYRQAQEAFAMQESMLL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z9K4-1", "uniprot_id": "A1Z9K4_DROME", "id": "A1Z9K4-1", "name": "", "aln": "---------------------MTDGEQQEALVKRAEDEREDIFRRYELGLDPSNVVDSWENPTFEIYHRTDKYGFLHDSRLPSTRDAQEVHRNKIEMERDKKWMKMLNQWPPPQ--DKLHKRVYKGIPDRVRMVAWNKLLDIQQSINNNAGVYLRMLQLARKYSTETRQIDADVNRQFRDNLAFRERYSVKQCSLFNVLNAYSIYNSELGYCQGMACVAGVLLLYLHEEEAFWALNTLITDQKYGMHGLFIEGFPKLTRFIDHHDRIMSKIMRKLHKHFTKHNVDALLYAIKWFFVVFVERVPFSLSLRVWDIFMLDGDRVILSMAITILYLHKDELLRLKDMDAIIEYLQVRLHKNFGYSDDDAIQALERVMKKLKDLKLDVPPPAKSNEFPTRKLG-----------------------------------------------------------------------------------------------------------DFVEADMEKKIGRRRNDYTDAEKQVITDVISRQEQNAIDVQSTVSYETSECATGDGYSMKTFESITSLATSPANSSYSLYSNG--------------------------------------------------FVVTTIDSEQDPAR------------------------------------------------------------------SQSIHNLSYLQTHPALPPNGLQHMRHSFSSDSDSRNRIDLDQALEVLQRQ--------------------------------------------------------QLPLHPKTPSSQVVYIVQNGGGGGRYMDGHRDAADDDDDDALSVENTRL-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.:: . : :** :*. :*: * : ::.**:. : :*: .*::****: .* . : :: ::*:** .**:***: * : :*: :*:***** ::* .* **:* : ::. ..* :: ** *.: **** **** :*::: * .**.*** .**:** ***:**:*:******: ::.:**:*::**:***** .*::. :: ***:*: ***** ** :**::*:.*:: **::*: .::: : :*::**** *::*.** *.**:***::::*:*:: :*: *** **:. *::*. *: :::::* * ::* :.** .*: *: * :*: **::* *.*.:*:* : ** . . :.:.::: : . :: . . : . . . . . . : . *. * *.* * * . : .. . : * . .* . : : : . . . * :.:::::: * ", "identical_positions": 153, "similar_positions": 190, "identity": "17.51%" }, { "cls_id": "homologset.agr.HGNC:16859", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O54960-1", "uniprot_id": "CAPON_RAT", "id": "O54960-1", "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "aln": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKK-----KKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTATAEETDIDAVEVPLPGNDILEFSRGVTDLDAIGKDGGSHIDTTVSPHPQEPMLAASPRMLLPSSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQ-----STMGSQDSLLEITFRSGALPVLCES-TTPKPEDLHSPLLGAGLADFAHPVGSPLGRRDCLVKLECFRFLP------AEDNQP-MAQGEP------------------------------------LLGGLELIKFRE---------------------------------------------------------------------------------------------------SGIAS-EYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV--------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D3A8-1", "uniprot_id": "CAPON_MOUSE", "id": "Q9D3A8-1", "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "aln": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKK-----KKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTAAAEETDIDAVEVPLPGNDILEFSRGVTDLDAVGKDGGSHIDSTVSPHPQEPMLTASPRMLLPSSSS-KPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQ-----NTMGSQDSLLEITFRSGALPVLCES-TTPKPEDLHSPLLGAGLADFAHPAGSPLGRHDCLVKLECFRFLP------PEDTQPMMAQGEP------------------------------------LLGGLELIKFRE---------------------------------------------------------------------------------------------------SGIAS-EYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV--------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75052-1", "uniprot_id": "CAPON_HUMAN", "id": "O75052-1", "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "aln": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDIDAVEVPLPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVS-HPQEPMLTASPRMLLPSSSS-KPPGLGTETPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQ-----NAMGSQDSLLEITFRSGALPVLCDP-TTPKPEDLHSPPLGAGLADFAHPAGSPLGRRDCLVKLECFRFLP------PEDTPP-PAQGEA------------------------------------LLGGLELIKFRE---------------------------------------------------------------------------------------------------SGIAS-EYESNTDESEERDSWSQEELPRLLNVLQRQELGDGLDDEIAV--------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9QB59-1", "uniprot_id": "A0A8M9QB59_DANRE", "id": "A0A8M9QB59-1", "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "aln": "MPAKTKYNLVDDGHDLRIPLHNEEAFQHGINFEAKYIGSLDVARPNSRVEIVAAMRRIRYEFKVKNIKKKKVNIIVSVDGVKVALRKKK-----KKKEWTWDESKMMVMQDPIYRIFYVSHDSQDLKIFSYIARDGQSNVFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGDADKTCTDSGVAGRELTGAEKP---AADETDIDAEELPLPDSTMDEFSRGVTDLDAAKKDEDVSKDKKPS--EEPVILLASPKLLLPSGSD-----LPSSTPLSVHHQLQLLQQQLTQQQQQTQVAVAQVHLLKDQLSAEAAARIEAQARVHQLLLQNKDLLQHISLLVKQIQELELKLAGQ-----GSMGSQDSLLEITFRANVPPVLCDP-STPRPEDSILPPLNDG-TQLSLPLCSPIGRDQGLIKFECFRFLPGPPHQQEEDSPDTPSQDVSS------------------------------SSRDELLGSLELLRFRE---------------------------------------------------------------------------------------------------SGIAS-EYESNTDESDESWGLQDESSLRLLNVLNKHIPSDCLDDEIAV--------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PJM9-1", "uniprot_id": "A0A8M9PJM9_DANRE", "id": "A0A8M9PJM9-1", "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "aln": "MLEKCKYNLVDDSMDQRIPADNEGQFQHGLTFEVKFIGSLDIVRPKSRIEILAAMRRIRYEFKIKNIKKKKVSLIVSVDGVKVVLRKKKK----VKFEYSWDESPVTLAQDPIFRIFYVSHDSQDLKIFSYIARDKKSNVFRCNVFKSKRKSQAMRIVRTVGQAFEVCHKQSLDNADA---WLVKGEEERSKDEAVAAG---SSTERAG-DADPETDEKVEEE--------------------------------------------------SKSP-------LSSPLSVSHQVQLLQRQFQQQEQRSHAASAQVVLLQQQLSVETNARTEAQARVQQLLQQNTELLQHLSLLVKHVQELELRTQPHKN---SPLGSQDSLLEIALRANMPAVSREPKPNPLLSAQRSFPLSNSLVRLDG-FHFFTGASEQEKKPEQDRDSG---RGQDEDQSGGSSPPEN-----------------------------------QFLSALDTPGFRE---------------------------------------------------------------------------------------------------SGIAS-GYESNTDESDDRDSWGQ---------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8SXX4-1", "uniprot_id": "CAPON_DROME", "id": "Q8SXX4-1", "name": "Capon-like protein", "aln": "-MPSTPYDLVQDDQDLRVPLHAEQAFFHGITFQAKFVGWEEVPRPNTRAEIVQAMRRIRYECKVQNLKKRKVTIHISVNGVRVVLKKRRR----KKKNWTNDPEDIELLNHPIYRIFYVSHDSSDLKIFSYIARDASTDTFKCSVFKSHKKSQAMRIVRTVGQAFEVCHKFNLHKNSLEPNDERSDISSSELLDVEQISEQQLSEDGERGGGDNETPKKEHLAITPDLNHTQPQR----------------PNHLDIMPSHSSLRKSNSLLCDVDDK------SPGSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNRELLEHLASLGAYNEQQTAGLTSANIGMAPQQSQLQMLLQATSNNNNLATINQQISNLGSINQQLTSLSHQLSGLNQQSQHLQNLQQQQQQQQQQQQQQTQAAPTAATPPPAAGGSSPYPSMSALQSISNQLQQQQQQQQQDALSKDLFQVNQELLNRLQALNLNANPGQSQPTPSATAHNSFFYVNPLSCTPATPNNNAGGAGGFNFLTSPAATGTLTPSPLGTMNRNSFAGSSSLNEDIRLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDTSRSSSTLDSPSSPRLRSSNNNISPGSSNGNQNHNNNSNSNSSSSRETRFNTVLLRVTDEAGHQRKLSATPSFITRSTSEKVPNRSQMMSQVQRTTWARHTTK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . *:**:*. * *:* . * * **: *:.*::* :: **::* **: ******** * :*:**:**.: :**:**:* *:*:: * ::: * . : : :.**:*********.*********** :: *:*.****::******************** .*.: . .. . . . : ** . . :* * :: *: : * ::: * .*: *:::** *: ** *****.:*** ** ::*:*:: * :: .. : **: : . . .. : .. *. : . : : : : . :*. *: :. :*:*. *. * * . . ", "identical_positions": 128, "similar_positions": 109, "identity": "17.66%" }, { "cls_id": "homologset.agr.HGNC:1686", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P24485-1", "uniprot_id": "CD53_RAT", "id": "P24485-1", "name": "Leukocyte surface antigen CD53", "aln": "MGMSSLKLLKYVLFFFNFLFWVCGCCILGFGIHLLVQNT-YGILFRNLPFLTLGNVLVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLLILLAEVTLAILLFVYEKKINTLVAEGLNDSIQHYHSDN--------STRMAWDFIQSQLQCCGVNGSSDWISG---------PPSSCPSGAD----------------------------VQGCYKKGQAWFHSNFLYIGIVTICVCVIQVLGMSFALTLNCQIDKTSQALGL----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61451-1", "uniprot_id": "CD53_MOUSE", "id": "Q61451-1", "name": "Leukocyte surface antigen CD53", "aln": "MGMSSLKLLKYVLFIFNLLFWVCGCCILGFGIYFLVQNT-YGVLFRNLPFLTLGNILVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTIAILLFVYEQKLNTLVAEGLNDSIQHYHSDN--------STMKAWDFIQTQLQCCGVNGSSDWTSG---------PPSSCPSGAD----------------------------VQGCYNKAKSWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQALGL----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P19397-1", "uniprot_id": "CD53_HUMAN", "id": "P19397-1", "name": "Leukocyte surface antigen CD53", "aln": "MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNN-FGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDN--------STKAAWDSIQSFLQCCGINGTSDWTSG---------PPASCPSDRK----------------------------VEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQTIGL----------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PDV2-1", "uniprot_id": "M9PDV2_DROME", "id": "M9PDV2-1", "name": "Tetraspanin", "aln": "MGNAGYTCIRRTFCWLNIILWLCSCAFLGAGLWLRLSYAGYATLLPQHAGLSADTIFMGIGGTGFVVSFFGCCGAWVQSRCLLVLYFMLIVMLFMSEFLVGSIAFLFRGGLGRTLANELRFGIERHYNSSDRGSLVAPSVASIWDSVQQSFECCGVSSYEDWYDIQSWPGRRWVPESCCRTLYDQRQVLTEGSGDGMMRPDCGRSENPSLWWDKGCAHSLQSWFTGQLNVVGAVGLGIAFVQLFGLITSMLLFCTVKHKRASDTYKSYSPSIDPQTRTSSWEDXTRL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :. . :: .: :*:::*:*.*.:** *: : : :. *: : . *: ..::: :*. :**:*:** *: :.:***: :*:*:::::::*. :. : *::. :. :*: * .*.:::... *. ** :* ::***:.. .** . * :.* : . :** . : ** .:: :* : : :..::::*: :: * * :.:. : ", "identical_positions": 47, "similar_positions": 104, "identity": "16.38%" }, { "cls_id": "homologset.agr.HGNC:16860", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZAS8-1", "uniprot_id": "D3ZAS8_RAT", "id": "D3ZAS8-1", "name": "Spliceosome associated factor 3, U4/U6 recycling protein", "aln": "--------------------------------MATATASSASEPEVEPQARPEAEGEEDEAKPAGVGRKVLS---SAETAKAKGPEREVHQEGVSESDGDEEDAAMASSAESSAGEDEW------------------EYDEEEEKNQLEIER-LEEQLSINGYDYNCHVGLIRLLRLEGELNKVRMARQKMSEIFPLTEELWLEWLHDEISMAVDGLDRERVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFESAIVEAARPIAAFLSPSDREQTFDSQLERVHSLFRRQLAIPLYEMEATFAEYEEWSEEPIPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKVGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQMISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTR-GNAKYANMWLEYYNLERAHGDTQHCRKALHRAV-QCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKK-TRGADKRKAGEDDDERECGEEEEEQPSKRRRMENSL-ASGVASAKEEETKLSGKCL--TIDVAPP--SKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSAQQALDLDRKNVEGRPMFVSPCVDKSKNPDFKMFRYSTTLEKHKLFISGLPFSCTKEELEGICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVLKMDGMTIKENVIKVAISNPPQRKVPEKPEVRTAPGAPMVPRQMYGARGKGRTQLSLLPRALQR-QGAAPQAENGPAPGLAATT-----SVATEAPKMSNADFAKLLLRK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JLI8-1", "uniprot_id": "SART3_MOUSE", "id": "Q9JLI8-1", "name": "Spliceosome associated factor 3, U4/U6 recycling protein", "aln": "--------------------------------MATTAASSASEPEVEPQAGPEAEGEEDEAKPAGVQRKVLSGAVAAEAAEAKGPGWDLQREGASGSDGDEED-AMASSAESSAGEDEW------------------EYDEEEEKNQLEIER-LEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFESAIVEAAR------------------LEKVHSLFRRQLAIPLYEMEATFAEYEEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTR-GNAKYANMWLEYYNLERAHGDTQHCRKALHRAV-QCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDE-ENEWGEEEEEQPSKRRRTENSL-ASGEASAMKEETELSGKCL--TIDVGPP--SKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKPEVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQR-QGAAPQAENGPAPGPAVAP-----SVATEAPKMSNADFAKLLLRK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15020-1", "uniprot_id": "SART3_HUMAN", "id": "Q15020-1", "name": "Spliceosome associated factor 3, U4/U6 recycling protein", "aln": "--------------------------------MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDG--DEYAMASSAESSPGEYEW------------------EYDEEEEKNQLEIER-LEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAAR------------------LEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTR-GNAKYANMWLEYYNLERAHGDTQHCRKALHRAV-QCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDD-EKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCA--AVDVEPP--SKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTSLEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETRKAPGGPMLLPQTYGARGKGRTQLSLLPRALQRPSAAAPQAENGPAAAPAVAA-----PAATEAPKMSNADFAKLFLRK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B3DJT0-1", "uniprot_id": "SART3_DANRE", "id": "B3DJT0-1", "name": "Spliceosome associated factor 3, U4/U6 recycling protein", "aln": "-----------------------------------MAATGNEEQTLLPDIEEEAEGMEREMESE-----------------------DDEEEGMG--------------VEHSEEEDEE------------------DTSEDERENEAEIQR-LEEQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRITEDESDREKVYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIWEAYREFEIVILSTVQPPPGTVPSQEQQELLSAQLERIHTLFRRQLAVPLMDMEGTYAEYSDWADDGVPETVTHQYRRALQQMEKGKPYEEALLVSEPPKLAEYQSYIDFEIKEGDPARVQIIFERALAENCLVPDLWIKYTTYLDRQLKIKDLVLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYLRRRVDFSKEWSRELDELRAAFSRSLEYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKARELWDSIMTK-GNAKYANMWLEYYNLERSYGDAAHCRKALHRAV-QCTSDYPEHVCDVLLNFERVEGSLEDWDAAVQKTETKLNRVCEQRARVAEKEALHARQEEEKAEQRRKVKADKKAQKKGQKANRTGDKRKAEDDDEEEWG-EEAELPSKRLRGEDDFDSTVTEELMETESGLFGRRAPPARKTEPPGFRKNQQGAPEPQRQPHDMPKEQRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTFRGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSMEKHKIFISGLPYSATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAISNPPGRRMKDEAAPSRFLG-AAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAKAENGTISAPHATVTDGETSLDTQTKSLSNEDFARMLLKK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W4D2-1", "uniprot_id": "RNP4F_DROME", "id": "Q9W4D2-1", "name": "RNA-binding protein 4F", "aln": "MDADKQLERQLEKELDEMPAEDLDDDAYDEYDLIVIPDQGKGSPQQGHSESPQQEEEHKSEELRQRSRPTWPPSSAGGDMTTIELISSDDEPSVEETEGGNAAGRGRARNDSSSSSDDVGVIEGSELESNSEVSSDSDSDSDNAGGGNQLERSYQELNALPSKKFAQMVSLIGIAFKLNDLEKIESSVLELQNLATVPAHVWLKYLKARLVVTQTDEERKAFEEQCAKALGYYYSIPLSEYVVNYLVDQGNVQNHVLWAKLLADYDVERPDFGDKLRSLISTITDENEAAAFVEMLQK--------------HCVTWTCNVEQRQMIKSVVDKFKQHLDETTRGWDWSEQHKAHVYDVETLSLDDDLKNAVIRFIFERSVAKFPIVDVLWLSYIEFIQFEGVTVPENEDENEVTAEMVAKRAKRLG-KGFLRNTELDLANRGVRSHP-SVQLNHRFLDLMERSDFELAEVDEEIRLILQRIVTDMDMTVELHLDYLAYRIRNTNASDE--QQVASLRAAFN----HAWEELTVLYGDQADTRYEVLQLWAQVEYTQLGSPDNGREIWRQIMGYPGSSIRGLLWLNFAQMESEYNGGHGTRDVLRKALSQPVLENGLMVQEFFRRYERCYGTYES-IAACQALDLPVEYVKPRSRIKPNSQSAYPRQQKLKPRQ-QQQQTNREPLNREQRRRQAHEQQQQQQQQQKHGIKKSRTEPSGG-------------------------------ATSPP---SKVKGPANAEAKESNFKYSPNMEINKIFVRNLHPACSKEE--LHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAG-RDGCLFKGMNISVAISNPPPRGTSAVKPSVAPKRR---------VPTSLIPTTLVRQEVAAKKLRLLLPEPG--------DISSTSASVDVAIKREANGEEQ---------KGDVQERDEQKGEEQKGEEQKGEEPKGEEQKGDDQIGEEQSGVEQ-KGDEKKEEEMPAAVP-----------------KSNDDFRKLFLKD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 107, "similar_positions": 319, "identity": "10.23%" }, { "cls_id": "homologset.agr.HGNC:16861", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O70260-1", "uniprot_id": "PIAS3_RAT", "id": "O70260-1", "name": "E3 SUMO-protein ligase PIAS3", "aln": "--------------------------------------MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPS-VQMKIKELYRRRFPR--KTLGPSDLSLLSLPPGTSPVGS---------PSPLASIPP--TLLTPG---TLLGPKREVDMHPP-LPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNS---CSDCDEIQFMEDGSWCPMKPKKE-----------------------------------------------ASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQ--------PSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGL----------------------------DLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFLGPLAPTLGSSHRSATPAPAPG--------------------------------------------------------------------------------RVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O54714-1", "uniprot_id": "PIAS3_MOUSE", "id": "O54714-1", "name": "E3 SUMO-protein ligase PIAS3", "aln": "--------------------------------------MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPS-VQMKIKELYRRRFPR--KTLGPSDLSLLSLPPGTSPVGS---------PGPLAPIPP--TLLTPG---TLLGPKREVDMHPP-LPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNS---CSDCDEIQFMEDGSWCPMKPKKE-----------------------------------------------ASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQ--------PSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGL----------------------------DLFSFLQTESQHYGPSVITSLDEQDTLGHFFQYRGTPSHFLGPLAPTLGSSHRSSTPAPPPG--------------------------------------------------------------------------------RVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y6X2-1", "uniprot_id": "PIAS3_HUMAN", "id": "Q9Y6X2-1", "name": "E3 SUMO-protein ligase PIAS3", "aln": "--------------------------------------MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPS-VQMKIKELYRRRFPR--KTLGPSDLSLLSLPPGTSPVGS---------PGPLAPIPP--TLLAPG---TLLGPKREVDMHPP-LPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSS---CSDCDEIQFMEDGSWCPMKPKKE-----------------------------------------------ASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQ--------PSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGL----------------------------DLFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPG--------------------------------------------------------------------------------RVSSIVAPGGALREGHGGPLPSGPSLTGCRSDIISLD------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z7P5-1", "uniprot_id": "A1Z7P5_DROME", "id": "A1Z7P5-1", "name": "", "aln": "MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLR-TNLEL-LAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQ---------PNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSE-----------------------------------------------TQILDTP------------------SKPAQKVEVISDDIELIS--DDAKPVKRDLSPAQDEQPTSTSNSETVDLTLS--------DSDDDMPLAK--------RRPPAKQAVASSTSNGSGGGQ----------------------------RAYTPAQQPQQSESPEQQASRQSPEKQ-TVSEQQLQQQQHEQPATAAVHASLLESLAAAVAD--------------------------------------------------------------------------------QKHFQLLDLAAVAAAAAATASSGQSQNAGP-------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12216-1", "uniprot_id": "SIZ2_YEAST", "id": "Q12216-1", "name": "E3 SUMO-protein ligase SIZ2", "aln": "-----MASVMSNNNNNNNNNNASYMFTNPLSNTGG-GLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTG------------------------AFKHPVASGQLPVTALQSTALPPYSQQQALAYS---------FTSPFYKPIVQIPDANKKLKQSAG-RGCTKMKFKVSKSNHDLLKS-NKSYKLYLFSGFSIPFIYETV--GHEAIDFPYPCELVFNGTKLEDNVKGLKKQNGTGNPANLTPYLKVPTEMNH--LDLHYLNIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQN--CNEDVEQVEISVDGSWKPIHN--------------------------------------------------SSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKS-FPTHVNPR----------NDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNY----------------------QDAFQMRSFLNQGATTNINDTPTNNSS--INSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQ--------RNPYGPNYNTTAQDRNLLG---------------------------------------------------IEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSG--------HGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFN---TSAQDNSEVVDLTSD", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q04195-1", "uniprot_id": "SIZ1_YEAST", "id": "Q04195-1", "name": "E3 SUMO-protein ligase SIZ1", "aln": "---------MINLEDYWEDETP-----GPDREPTN-ELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVTGG-RGMCSAKFKLSKADYNLLSNPNSKHRLYLFSGMINPLGSR----GNEPIQFPFPNELRCNNVQIKDNIRGFKSKPGTAKPADLTPHLKPYTQQNN--VELIYAFTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQN--CQKNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : ::* **: : . :*:* * :*: : : . . . . : * . . . : : . ..: : :. :: . : .: : : : . : . . .* ::*. : . : :.* : ::*. ::. ** :: : : : :*..* : : : ** :** **:. :: *.:: * *:*.*** :*: : : *** **:*: :.* *. . ::: . .: :::: **.* . : . . : . . . :: . . . . .. . . . . . . . * . . . :. . : . ", "identical_positions": 42, "similar_positions": 133, "identity": "4.53%" }, { "cls_id": "homologset.agr.HGNC:16862", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q92565-1", "uniprot_id": "RPGF5_HUMAN", "id": "Q92565-1", "name": "Rap guanine nucleotide exchange factor 5", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSSRLRVFDPHLERKDS------------------------AAALSDRELPLPTFDVP---------------------------------------------------YFKYIDEE----------------DEDDEWSS--------------------RSQSSTED--DSVDSLLS-----------------------------------------------------------------------------------------------------------------------------------------DRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDD-----FLLTYTVFMT-----TDDLCQALLRHYSAKKYQGKEENSD---VPRRKRKVLHLVSQWIALYKDWLPE----DEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQY--AEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQ-RSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKP---PKIPFMPLLLKDVTFIHEGNKTFLDN--LVNFEKLHMIADTVRTLRHCRTNQFG--DLSPKEHQELKSYVNHLYVIDS--QQALFELSHRIEPRV--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P83900-1", "uniprot_id": "RPGF5_RAT", "id": "P83900-1", "name": "Rap guanine nucleotide exchange factor 5", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSSRLRVFDPPLERKD-------------------------SAALSERQLPLPTFDVP---------------------------------------------------YFKYIDEE----------------DEDDEWGS--------------------RSQSSTED--DSVDSLLS-----------------------------------------------------------------------------------------------------------------------------------------DRYVVVSGTPEKILEHLLNDLHLAEVQHKETETLLDD-----FLLTYTVFMT-----TDDLCQALLRHYSAKKYQGEEENSD---VPCRKRKVLHLVSQWISLYKDWLHE----DEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHSYISVKAKVSSTAQEILKVVAEKLQR--AEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLNPFAENEESQQ-RSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKP---PKIPFMPLLLKDVTFIHEGNKTFLDN--LVNFEKLHMIADTVRTLRHCRTNQFGS-DMSPKEQQELKSYVNHLYVIDS--QQALFELSHRLEPRA--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C0Q9-1", "uniprot_id": "RPGF5_MOUSE", "id": "Q8C0Q9-1", "name": "Rap guanine nucleotide exchange factor 5", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTGDCQTLSRRISNPYLEHSPSQIYGENSSCA---GRALRNIIILQAADLVKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMSSVDQHLYFQDNYVFYQFSSDECSYLYCE--------FEREEEWQKGVKLLLELVHLIPARAGICDLSHQKTEDSEESSDEILARLTSAVQRELAAVIALKARKSAIEQDDENADKHVTVTEANNGPDPQAGVMCKLQERDDIGRIELVHKLARENCQFLQTEKKESEKLEQQDDEVTMVQVKEQGQSVLVLKK-----------VASCGPAPTSGSAENDARYVVVSGTPEKILEHLLNDLHLAEVQHKETETLLDD-----FLLTYTVFMT-----TDDLCQALLRHYSAKKYQGEEENSD---VPCRKRKVLHLVSQWISLYKDWLHE----DEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGVYRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYITEHSYISVKAKVSSTAQEILKVVAEKLQR--AEEDLALVAITFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLNPLAENEESQQ-RSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGNGENTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKP---PKIPFMPLLLKDVTFIHEGNKTFLDN--LVNFEKLHMIADTVRTLRHCRTNQFGS-DVSPKEQQELKSYVNHLYVIDS--QQALFELSHRLEPRA--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A1Z6P8-1", "uniprot_id": "A1Z6P8_DROME", "id": "A1Z6P8-1", "name": "", "aln": "MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGG--MDPFLDD-----FLLTHIVFMP-----VVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFE----EPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP---PLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDN--QRVLTAMSQKVEPTRKL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25300-1", "uniprot_id": "BUD5_YEAST", "id": "P25300-1", "name": "Bud site selection protein 5", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------MSPKNKYVYICVEYIYIYFAKIHKQSTLSSDTTKMFVLIDNVLAYLLEQDD--------------LFVTARFAIQGQIVSRRVNKIHISN------------------------------------------ITDVLLQQFISHT---------------LPYNDNIVP------------KKILDSMRTAVRQLLEATACVSR-------------------------------------------------------------------------------------------------------------------------------------------ECPLVKRSQDIKRARKRLLSDWYRLGADANMDAVLLVVNSAWRFLAVWRPFVNSIQHATQELYQNIAHYLLHGNVNIQRVTALIQLVMGQDDLLFSMDDVLQEVFRIQLYLNKMLPHNSHKWQKPSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKNKHKNHSVPR--LIQIWVESYWQDSETTLKDILNFWYSHLAEYYEYQELFADIVQLFINKKRTRQLKIHY----IGLTDKEIEENKPPLDYENLFLQYEIDKTNANDELCGATDLSDLLFQWKQGE--LLEVEAFALNVSPWSLAKTLTLLESSLYLDIETIEFT------RHFKHNDTTIDSVFTLSNQLSSYVLETTLQQTHT------ISYWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPIDVKS---DHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIRDGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSNTTARSLLGAMIKVHTLYNDNKDRAYQVSIAKVPRLT-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . . . :: . ::. : : . * : ::**. . :* ** . *: . :* : : .: : . : . :: : . : : : : : :: . : . . .. . .: :: : * : : *:: .*. : . : : . . .* * * : * . :.. .** : :: .*: :. *: : . ..:. .: *::. :: : . : ::::* * :***:: ::: .*.. ::.**. . : . ::*..:: : .*. *:..** . :: * :** .**::*:** ::**.* .. **::*:: ::. : :. : .. * . .: . : . .: . : :* * ", "identical_positions": 50, "similar_positions": 167, "identity": "4.86%" }, { "cls_id": "homologset.agr.HGNC:16863", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K019-1", "uniprot_id": "BCLF1_MOUSE", "id": "Q8K019-1", "name": "Bcl-2-associated transcription factor 1", "aln": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKS-ATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPREESRGRSSFYPEG-DQETAKTGKFLKRFTDEESRVFLLDRGNIRDKEAPKEKGSEKGRADGDWDDQEVLDYFSDKESAKQKFHDSEGDDTEETEDYRQFRKSVLADQGKSFATSSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETAYIVERPSTAKDKHKEEDKGSDRITVKKEVQSPEQVKSEKLKELFDYSPPLHKSLDAREKSIFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQANKSTSESFIQHIVSLVHHVKEQYFKSPAVTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERGFKEEIQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKPYKDDSKHKGRERDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKDYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDDEETMENNEEKKDRRKEEKE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NYF8-1", "uniprot_id": "BCLF1_HUMAN", "id": "Q9NYF8-1", "name": "Bcl-2-associated transcription factor 1", "aln": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHK-REQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0K035-1", "uniprot_id": "MTFR2_RAT", "id": "B0K035-1", "name": "Mitochondrial fission regulator 2", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQRDGTNEQCFLELASPMS-----FILNILRNMLAYFGVPVDQDLLIFQNKDYGSARSIVRVIGRMLP-------LEPCRRPRFELTPPANAKEVD-----------------------------------------------------------------------DYELAVPSFADVLCVADDGEAGCLRFRHSLWKKAEG---------------------------------KAALFHPSKLPWDLSSPALSQNRTVADDLPVSEAAIKKIAALEDELTS--LRAQIAAIVAMQDLGGGGETGFISLSDGPSMEQVPPSSATARLSVEPDHVPSVVLSPPPLPPPPPPLPPPQFSLQPPSS--------LPVPPGSANTRG-----------------IDNLAAEMKKRPSGVKKTDGSHHS-----ESQRVSDVP------------------------------NMLDVLKDMN-KVKLRPVER--------SPGGRPIQKR------------------------RRQSSQWDPVSLISNALKQKFAFQDDSFDSENRSWQGSPFS---------------------------------------------SPETSRNGSRF--------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. . :. :*:* * :* .: : ..* ::. * :. : ..: *: . .* * *.**. : .* ** . : * * . .* * : . :**:*: . : :: .: : :. *: :::: :* .. ::** . :::.* *: : .::. .. *.. : .. :: :...* ..:.:: ** . *. . *... . .. : :* .. .* :.. * :::* :. :*: .* : * :* *:. : *: :*:: : * *. ** *.*.* :* * .**. .* * *. *:. :::.*.:.:. : * *: .** : :..:: ", "identical_positions": 65, "similar_positions": 151, "identity": "7.06%" }, { "cls_id": "homologset.agr.HGNC:16864", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7F1S0-1", "uniprot_id": "F7F1S0_RAT", "id": "F7F1S0-1", "name": "", "aln": "-MPVSRFAGRLRKDSSIEMIRTSLAHRKSLSQKENRHRVYERNRHFGLRDVNVP----------LEGRDLVNIHEMSQDLTLE------NASSKTKSVKMVLSDQRKQLLQKYKEEKQ-----------LQKLKEQREKAK--VFKVG-------------LYRPAAPG--FLVADQRG-------VKAEPQKAFPYTGRITRSKARDHMEQSKTGSRNIPQAAQFGQRQISEKKPLDREKKVMQPMGPTSGKAAGSVAATQRAKQMAGTVPSTT-------------RKPVTRATNENGSERRGPSRGRPAGKAEGELDKIISSQGIALGSEEKHLQSQS---------SVTNEVESLQETVPAKGRERESFAPERCAFQPPRGLKTYQVAPLSPRSANAFLTPSCDWNHLRPEVA----------TAQDTANEVLVQQESNKSQFGLDSQTDSRKERGLNQKDASTPNSDHLSVKGITSSEAGDGQTGQPQHDVPYFRKILQSETDRLNSHCLDWEK------KLELDIPDDAKDLIRTAVGQTRLLIMERFRQFEGLVDN---CEYKRGEKETTCTDLDGFWDMVSFQVDDVTQKFN---NLMKLEESGWKDNNNP----SKKVIRGLPTPAGPHLFCQTVLLTGDQPSPHKKIVPGKTSKAKQDEDGRTAARSRLAAIKNAMKDRLRQEAQAQAAVPEIPTAADKIVFDAGFFRIESPVKSFS--VLSSERRSQ-FGAHVSASRAVPEGRAAGDLLRQKTPLKRPDPQSSTIEHVDRTFSDGLESRCSQVEDILCPVQQDSSDVERDVNKIKVKMESFSVATMNLPLPAGEVAGDANSNQKDAVSAAAVEGVG--SAVLSQDVLMSHPETNAFSQRDSLQEG-AELSQSVLLH-KSLTSECHLLGP---PDLSCTSPCTREDTRQQDRGRQFSFGGNLIVFSPLRP---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4R9-1", "uniprot_id": "DLGP5_MOUSE", "id": "Q8K4R9-1", "name": "Disks large-associated protein 5", "aln": "-MLVSRFASRFRKDSSTEMVRTNLAHRKSLSQKENRHRVYERNRHFGLKDVNIP----------LEGRELGNIHETSQDLSPE------KASSKTRSVKMVLSDQRKQLLQKYKEEKQ-----------LQKLKEQREKAKRGVFKVG-------------LYRPAAPG--FLVTDQRG-------AKAEPEKAFPHTGRITRSKTKEYMEQTKIGSRNVPKATQSDQRQTSEKQPLDRERKVMQPVLFTSGKGT-ESAATQRAKLMARTVSSTT-------------RKPVTRATNEKGSERMRPSGGRPAKKPEGKPDKVIPSK---VERDEKHLDSQTRETSEMGPLGVFREVESLPATAPAQGKERKSFAPKHCVFQPPCGLKSYQVAPLSPRSANAFLTPNCDWNQLRPEVFST--------TTQDKANEILVQQ-------GLESLTDRSKEHVLNQKGASTSDSNHASVKGVPCSEGSEGQTSQPPHDVPYFRKILQSETDRLTSHCLEWEG------KLDLDISDEAKGLIRTTVGQTRLLIKERFRQFEGLVDN---CEYKRGEKETTCTDLDGFWDMVSFQVDDVNQKFN---NLIKLEASGWKDSNNP----SKKVLR-------------------------KKIVPGRTSKAKQDDDGRAAARSRLAAIKNAMKGRPQQEVQAHAAAPETTKEVDKIVFDAGFFRIESPVKSFS--VLSSERRSQRFGTPLSASKVVPEGRAAGDLLRQKMPLKKPDPQSSKSEHVDRTFSDGLESRC-HVEDTPCPGEQDSSDIEHDVNKINVKMDCFSVETN-LPLPA----GDANTNQKEAIS--AVEGAS--TAVTSQDLLMSNPETNTSSQSNTSQEE-AEASQSVLLH-KSLTSECHLLEP---PGLSCTSPCTREETRQPDRSRQFSFGGDLILFSPL-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15398-2", "uniprot_id": "DLGP5_HUMAN", "id": "Q15398-2", "name": "Disks large-associated protein 5", "aln": "-MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPT---------LEGRILVELDETSQGLVPE------KTNVKPRAMKTILGDQRKQMLQKYKEEKQ-----------LQKLKEQREKAKRGIFKVG-------------RYRPDMPC--FLLSNQNA-------VKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMT--RSATQAAKQVPRTVSSTTA------------RKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCK---VDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFEWDR------KLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDD---CEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFN---NLIKLEESGWQVNNNMNHNMNKNVFR-------------------------KKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGIS-DVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLTTECHLLDS---PGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7K3L1-1", "uniprot_id": "MARS_DROME", "id": "Q7K3L1-1", "name": "Guanylate kinase-associated protein mars", "aln": "MQRHKELYKEQSLVLSPRNHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKIKQLAAAQAALTQENVAPKLESPERLDTKPAELLKESNPKVSRQKLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQPGIEAKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAP-VTRRANVVKPQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAELLHAATLDIPPLTPLDDIHNPFIDQATS--TQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQTTVKEDTGDSTLVPEGTKTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTT--------------------------KKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDN--LKRWKANDWLDPDAVAEEPKQPKPKPKISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEEPTLEDGLPATSSRHSSPRVIVVRNRRSFSPARTVLRMSTGEGRQSIAPNALLKSAILAAAEQNAAKTPPPKPRTSILKTPGTTKRQNRGVLFSAKKSVRRFQFTYEEGNISNDETVGADKLEDCEEDMSLEASTESGSLEQNPGRDSNQENEATPRTYTLRNRRVNLRPSSEFM-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..: . * . . .* . :: ::*. : :** :.: . : * . : * .: * : ::. * * * : : * **.** : .:*:.: .* *:* ::* ::::: . *.. *. . : : ... :: . ** .: ::: . :*: *: : : . ** :. *:. .* ::* . ::: . .* * .* . . :* : : : : :..*. . . . : : : . * *: . ::*. :.* :: . .. . : . . :. .: . . .: . .* .. : : .: . : : : . .:.: . :: .: *:.. :. :: * :: * :*. :.. *: ::. :* . : * :*: :* * .: : * : :. .: : * . ..: .: : :: . . . ** :: .. . :. ::.* . . * . : . . :* ... :.:. *. . . : * : . * * * : *: :. . . :: .: :: .:... :* . .:: . . * * . .. .* : .: * :: . : : * ", "identical_positions": 71, "similar_positions": 260, "identity": "7.45%" }, { "cls_id": "homologset.agr.HGNC:16865", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q568Z9-1", "uniprot_id": "PHYIP_RAT", "id": "Q568Z9-1", "name": "Phytanoyl-CoA hydroxylase-interacting protein", "aln": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNVLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELIFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K0S0-1", "uniprot_id": "PHYIP_MOUSE", "id": "Q8K0S0-1", "name": "Phytanoyl-CoA hydroxylase-interacting protein", "aln": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNVLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELIFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92561-1", "uniprot_id": "PHYIP_HUMAN", "id": "Q92561-1", "name": "Phytanoyl-CoA hydroxylase-interacting protein", "aln": "MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**************************************************************************************************************************************************************:*******************************************************************************************************************:*******************************************************", "identical_positions": 328, "similar_positions": 2, "identity": "99.39%" }, { "cls_id": "homologset.agr.HGNC:16867", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3U319-1", "uniprot_id": "BRE1B_MOUSE", "id": "Q3U319-1", "name": "E3 ubiquitin-protein ligase BRE1B", "aln": "------MSGLS--NKRAAGDGGSGPPEKKMNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSS-----GTEVPGCQEGLTRDVIPRPDP----------------------GTSDLREPLPVQFR-----------------------------APLSEPALAFVVALGA---SSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARVRTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSG------------SSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDT-LAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCIPTLSHPDDPGLNALAPGKED---SGPGPGGTPDCKKEMALLAGATSATSSIKKEELVSSEDDAQALTP-------VTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATK-----------------------QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRS-------QALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVY------ADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8CJB9-1", "uniprot_id": "BRE1B_RAT", "id": "Q8CJB9-1", "name": "E3 ubiquitin-protein ligase BRE1B", "aln": "------MSGLS--NKRAAGDGGSGPPEKKLNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSS----GTEVPGCQEGLTRDVIPRTDP----------------------GTSDLREPLPMQFR-----------------------------APLSEPALAFVVALGA---SSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSG------------SSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDT-LAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCGPNLSHPDDSGLNALAPGKED---SGPGPGGTPDSKKELALVAGATSVASSVKKEELVSSEDDAQALAP-------GTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKAEEARRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRDLEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATK-----------------------QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRS-------QALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVY------ADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75150-1", "uniprot_id": "BRE1B_HUMAN", "id": "O75150-1", "name": "E3 ubiquitin-protein ligase BRE1B", "aln": "------MSGPG--NKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS-----APEAPGTQEGPTCDGTPLPEP----------------------GTSELRDPLLMQLR-----------------------------PPLSEPALAFVVALGA---SSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSG------------SSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDT-LAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEE---GGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITP-------GAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATK-----------------------QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRS-------QALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVY------ADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32U5A5-1", "uniprot_id": "A0AB32U5A5_DANRE", "id": "A0AB32U5A5-1", "name": "E3 ubiquitin protein ligase", "aln": "MSKKGSMSGAGGGKRPSGGDSPPGPPEKKLKKEEKTTTTLIEPIRIGGVSSTEEMDMKVIQFKNKKLCERLEQRQALEDELREKIEKLEKRQATDDTTLLIVNRCWTQLEENIHELLQHVEPKDAPAPVQIPATPPVPADAPVPAVAPSPAPEPSAPLPAPVEGEDGLPQPSVAAEGTEDQQQPSQEKEQQQEQQQQPDSVEKSAEAPVADEIPAPSPLPPLSESAKAFLAILDN---SSEEELTLQLQDRMQFSKGAVACMVCIFDRLHTSIDKLCTRVESAACEDDSQRDIATTNRKLLEENNRLYDLASSLQGKHHKMSLEYNELVDKVTSSETKVSEMETAVEDLQWDIEKLRKREQKLNKHLAEALEQLNTGYHATG------------SSGGLPGGQITLSIQKFESLNAELEQNQELANSRMAELEKLQQELQEAVREGEKLKMDLRNIPEEVLKETPEYKCLQSQFSLLYNESLSVKTQLDEARALLLTAKNAHLRQIEHMESDELSLQKKLRTEVIQLEDT-LAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDVQRYKRKLRETQMEINKLKCQS----------------GEATALILEES---VGDG--------------------GLEVKKEEDDDQEEEEERRRE-------LER-QRAREREREAERERE-RERE-----------------RERQRSEELKRKDSDTLKMLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAEKKSKAEVEELRQRVRELEEREKKESKKLADEDALRKIRVAEETIEHLQKKLAATK-----------------------QEEEALLSEMDVTGQAFEDMQEQNSRLMQQLREKDDANFKLMSERIKSNQIYKLLREEKEELADQVLTFKTQVDAQLLVVQKLEEKEGVLQSTLATLEKELALRT-------QALELNKRKAVEAAQLAEDLKVQLEHTQTKLREIQASVLDNRTARERESVNLKKAQEDLSRLRRKLEKQKKVEVY------TDADEILQEEINQYKAKLRCPCCNTRDKETVLTKCFHVFCYECLKTRYDTRQRKCPKCNAAFGANDFHRIYIT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VRP9-1", "uniprot_id": "BRE1_DROME", "id": "Q9VRP9-1", "name": "E3 ubiquitin-protein ligase Bre1", "aln": "------MSKRS----ADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAET---------ADELENRNENEVTTSFLAQLS--------------------TWDKEELDEKLANRVQ-------------------------------VSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDV-LALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQ-------QAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSG-----TTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYLQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07457-1", "uniprot_id": "BRE1_YEAST", "id": "Q07457-1", "name": "E3 ubiquitin-protein ligase BRE1", "aln": "-----------------------------MTAEPATKKIKLELSDP----SEPLTQSDVIAFQKEALFRCINRRRVDFEALRKQYELS--RRECIDVSRKLAN--------------------------------------------------------------------------------------------------------------------------IMALIVTLAR------------------------------------FIETFCTDANEK---QLCREIAQGDETLIVQRSDSFMKLLTKYGKPNTTDSNTNSNASDHIQELTTELKNLRKSKEELFYENSQLTEEISALKEYYTNIIRKYDR--------------------DESFTIKRVFKEDKTDAVKELREDEKESNENNIKSGNKDSSAINGDNTSKKSEKGDELVQAEDERKEDAE------------NEKLELDLKFSDLRAEINS-LSSTIKDLENIRRENEEELIKTRSEVSNLKKQQIAAADQDPDFKSYDHESLLAKIQHLTEQNAELSEINSSFLSKFQVLAKEKEIYTKKVREEFQKS-----------------------------------------------------------------------------------------------------------------------------------------------LDSLVEMNSSLEKDVVR----------IRTARDDLLSKIAILEAEKSKTEVLSDLQHAIDILKEQWTKIDQRSNDTKSS--------------------------------------------STQDALIKEIQDLEKGFRELSDLTHKKYSEIINHESVISKLTVEKTKADQKYFAAMRSKDSILIEIKTLSKSLSKSNELILQLKDSDRLLQQKIGNLHKQLDLSQNNERRLIDSSKTETLKIIDLNNTSTKLKRSLEKLQEESNKSIADMTHLETKLNDTEIELKHFKQKASHLESKCEKLHDTLFRGNNKNKGSSDEALVEELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTCNKAFSSNDLLTVHL-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .. :* : : .*: *::: * . :::* **.: * *: *. :.* * :. : . . . . . . : .. : .* :. * .: * *: ::.. ::* :: .:: . . *::: :: :.: . .. : : :: *: :* :..: . :* . : * .*. * * **.:.:. :.: * : : . ::.:* :. :: * *:*: :::. :* :: : :.*. :* :: * *: .: :*: .: * : : *.:* :: . : : :.:.*:* : . .: .*: :: :*:. :.:*: : *:* . :: * .: ::**:.*:: :.*.::.: . : .:: :::.. ** *: *::* : ..* : :: ...:. : :*::.: ** .:. :.*:* * :: : .. * :: : : .** **: : . .: : . : : : *: ::. :::. * *: :. . ** : **: ::: : *. *. . *: .:..* **** :* : * :* ****.** **.::* ::: ", "identical_positions": 97, "similar_positions": 263, "identity": "8.61%" }, { "cls_id": "homologset.agr.HGNC:16869", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6A058-1", "uniprot_id": "ARMX2_MOUSE", "id": "Q6A058-1", "name": "Armadillo repeat-containing X-linked protein 2", "aln": "MSRARDAGCVAAGIVIGASAWYCVYKYTRGKDQKKKRLTKPKNRASVGTGSRARAGLRAGFTIDLGPGFSPPNPVDIEIMNKAQGEASNLATTVAEEVAPAAPSPKVQNGAESKVQELNGAKTEANLESVVMPSATCTVTPPPKVAGGLTAAEAPEIIGAPKVLEAPSTTEASGAVAAPGPTVSPMIAQTPGPVVPSPTIVSTGPAAIPWAVAHPGAVQSPGPAVPPMAVQSLVPAAPSWAVVAPPGAVYIPVAAHFAGPAAASRVTQSPGTVIPPLPPPSSVLPRGVPSVPGRTVQSPGAAVHPVAAQSTGVVVPPRAVQYSGAAVTSGGAAVPSGGAATPRAAASTQRTASTEVMQVPRVAAATEATETPRIGTPAMVAEASLPVHSGAAENPGTSGSSKTAATGKKAAPGAHTGAIPKAGSATGAVPKGGGGKGGNKNRSGGKGKNRKNKVDVDELGMGFRPGDGAAAAAAASANGGQAFLAEIPESEEGESGWTDTESDSDSEPDVPQRGKGKRTIPMHKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLGTQVPSSFSSLYNSYVESEILINALTLFEIIFDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q642B5-1", "uniprot_id": "Q642B5_RAT", "id": "Q642B5-1", "name": "", "aln": "MSRARDAGCVAAGIVIGASAWYCVYKYTRGKEQKKKRLAKPKNRASVGTGTRARAGLRAGFTIDLGPGFNPPTPVSVETMNKAE-EASSLATAVAEEVAPTAPSPKVQNGAERKVQELKSG-TEANMESIVMTSAACAVTPPPKVTGPLTAAEAPEIVGGPKVVETSSTTEASAAVASLGPAVSPRVAQSPGPAAPSPSIVSPGPTAIPWAVAHPGTVQSPGSAATAMAVQSLVPASPSWAVVAPPGAVYIPVAAHFTGPAAAPRITQSPGTVIPPLPPPSSVLPRGVPTVPTRTVQSPGAAVHPVAAQSPG-VVPPRTVQYS-------GATVPSGAPATPRAAASTQRAATTEV---PRAAAPAEATGTPGTGTPAVVAEASLPMHSGAAETPGTSGSSKTAATGKKAAPGVHTGAIPKTGAATGAVPKGGG-KGGNKNRSGGKGKNRKNKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEIPESEEGESGWTDTESDSDSEPEVQQRGKGKRTIPMHKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDVMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLGTQVPSSFSSLYNSYVESEILINALTLFEIIFDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7L311-1", "uniprot_id": "ARMX2_HUMAN", "id": "Q7L311-1", "name": "Armadillo repeat-containing X-linked protein 2", "aln": "MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVP--------TEAAAPTEVTEGP-----------------------------------------------------GVAAPTKVAEAPGVASP-----------------------TEAAEAPVPATPTG-------------------AAAPTGAAESPGTSGSPR-----------------------------------------TAVVPGTS-------AAKKATPGAHTGAIPKATSATGAVPKGGG-KGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***.**************.***********::*.***::****** .***:***************.**.**.** * ::*: *** * *. ** ***:*.*.:.*.** :.** ... . .: **:* .: :.:::*** *: * ***** : *.*** *:. :*:* *... *..*. . ..:*: *: ** * **..:::::**.. * . ** **.* ..* *:.*:*.. :* ::.*.: :* **** :.***:**.*******: :********** ** .:.*.*****.:*.**:*******************************:*:*******************:. :**:*:*.:.*:********************************************************************************************************:**********************************************************************.****:*************************:******************************************************", "identical_positions": 476, "similar_positions": 111, "identity": "60.71%" }, { "cls_id": "homologset.agr.HGNC:16870", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q61846-1", "uniprot_id": "MELK_MOUSE", "id": "Q61846-1", "name": "Maternal embryonic leucine zipper kinase", "aln": "------------------------------MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDN-VMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRSSR---------QTMEDLISSWQYDHLTATYLLLLAKKAR-----------------------------GKPARLQLLSFSCGTASTTPKS---------------------------KNLSLEDMSTSDDNCVAG----------------------------LIDYELCEDKLLA----PKTPQVT------------KHLAESNHAASK------SPAPGVRRAVANKLMDKENVCTPKSSVKNEEQFVFSEPKIPVS--KNQYKREIPASP----TRFPTPAKARAQCLREAPVRTPG---NSAGADTLTTGVISPERRCRSMDVDLNQAHMEDTPK----KKGTNVFGSLERGLDKVLT---------ALTRNKKKGSARDGPRKRKLHYNVTTTR--------------------------------------------------------LVNPDQLLSEIMAILPKKNVDFVQKGYTLKCQTQSDFGKVT-------------------------MQFELEVCQLQ----RPDVVGIRRQRLKGDAWVYKRLVEDILSGCKM------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A6T6-1", "uniprot_id": "D4A6T6_RAT", "id": "D4A6T6-1", "name": "Maternal embryonic leucine zipper kinase", "aln": "------------------------------MKDYDELLKYYELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGSDLPRVKTEIDALKNLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVIFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDN-VMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKRRISMKNLLNHPWILQDYSCPIEWQSKASLTHLDEDCITELSVHHRNSR---------QTMEDLISSWQYDHLTATYLLLLAKKAR-----------------------------GKPARLQLLSFSGGTTSTTPKASCRRPVCDLLISPAALFRSRPSKPVQSKNLSLEDMSTSGDSCVAG----------------------------LIDYELCEDNLLA----PQTPQFT------------KHWAESNHVECE------SPTPVVCRALANKLKDKENVCTPKSSVKNQEQFVFSEPKIPVS--RNQYKREILTSP----TQFTAPAKARTQCLRETQVRTPV---NSAGADTLTTNVISPERRCRSMEVDLNQAHMEDTPK----RKGTNVFGSLERGLDKVLT---------ALTRNKKKGSAKDGPRRRKLHYNVTTTR--------------------------------------------------------LVNPDQLLNEIMAILPKKNVDFVQKGYTLKCQTQSDFGKVT-------------------------MQFELEVCQLQ----RPDVVGIRRQRLKGDAWVYKRLVEDILSGCKM------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14680-1", "uniprot_id": "MELK_HUMAN", "id": "Q14680-1", "name": "Maternal embryonic leucine zipper kinase", "aln": "------------------------------MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDN-VMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNR---------QTMEDLISLWQYDHLTATYLLLLAKKAR-----------------------------GKPVRLRLSSFSCGQASATPFTDIK-----------------------SNNWSLEDVTASDKNYVAG----------------------------LIDYDWCEDDLSTGAATPRTSQFT------------KYWTESNGVESK------SLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVN--KNQHKREILTTP----NRYTTPSKARNQCLKETPIKIPV---NSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPK----RKGAKVFGSLERGLDKVIT---------VLTRSKRKGSARDGPRRLKLHYNVTTTR--------------------------------------------------------LVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVT-------------------------MQFELEVCQLQ----KPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QGZ6-1", "uniprot_id": "MELK_DANRE", "id": "F1QGZ6-1", "name": "Maternal embryonic leucine zipper kinase", "aln": "----------------------------MPVDSTSELLKHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDDLPRVKIEIEAMKNLSHQHVCRLYHVIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLLIDEDHNLKLIDFGLCAKPKGGLGFELLTCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYALLCGFLPFDDDN-CMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWVMRGYSTPVEWHSKYPLGHIDEDCITEMAVTFKQSK---------QRTIQLVSEWKYDQITATYLLLLAKKRQ-----------------------------GRPVRLRAECPVIDIVCSPLQDMQLK-----------------------KSLRFTEDDDGVHPVVLGS--------------------------MVFPPDCYDDENPWTPLTPKNTHTTNTPRMKLYPETTEKWNEMAYSPVI------EHSRPCRQKPERRERTKENKENLAVPGTDGDVFALPAPRTPTSSRKVKSNRTVMTTPNHNNNKSSEVNKGAGSATKEGSRRREVEQQQNGQQGELNILAFSPERRSRS--LDLAGCQVDSGQK----RKGGKVFGSLERGLDKVIT---------MLTPSKKRG-PRDGPRKIKAQYNVTLTN--------------------------------------------------------QTNADQVLNQILSILPEKNVDFVQKGYTLKCHTQSDFGKVT-------------------------MQFELEVCLLQ----KPEVVGIRRQRLKGDAWVYKHLVEDILSSSSQWSA---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q12152-1", "uniprot_id": "YP150_YEAST", "id": "Q12152-1", "name": "Putative serine/threonine-protein kinase YPL150W", "aln": "MVNPVGSSKLEQNNIKSIIGSSYNRLYSQFTSDELTEVGNYKILKQIGEGSFGKVYLALHRPTHRKVCLKTSDKN-----DPNIVREVFYHRQFDFPYITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTR--ECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPDDARDLISRLLAKNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSKLERRLLKRLKQSGVDTQAIKQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKVIESATHNDTNGISEDVLKPSLELSRAASLSKMLNKGSDFVTSMTPVSRKKSKDSAKVLNPTLSKISSQRAYSHSIAGSPRKSNNFLQKVSSFFKSKKSSNSNSNNSIHTNVSESLIASNRGAPSSGSFLKKNSGSIQKSRTDTVANPSRTESIGSLNENVAGAIVPRSANNTTLENKKTSGNEIGLKVAPELLLNEHIRIEEPRLKRFKSSISSEISQTSTGNYDSESAENSRSISFDGKVSPPPIRNRPLSEISQISNDTYISEYSTDGNNSSFKISDTIKPSYIRKGSETTSQYSASSEKMTNGYGRKFVRRDLSIVSTASSTSERSSRTDSFYDITTATPVVTTDNRRNKNNNLKESVLPRFGTQRPWTGKRTYTTSRHGKNARRSSKRGLFKITSSNTDSIIQEVSSSEEEDHNVIYSKGKGLPTPVLQTKGLIENGLNERDEEGDDEYAIHTDGEFSIKPQFSDDVIDKQNHLPSVKAVATKRSLSEGSNWSSSYLDSDNNRRRVSSLLVEDGGNPTA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. : *:: : ** *.*.** *. * * . *.:* :*: *.: *: :.: . :: :**.*: * .*::*.****** **:*:::: *:* * .* ** .*: *.** .***** **:*:*: : ** ***: : * * **: .* *****: ::* * : *:**:*::**.*: *:******: . :: : . .: :. .: *:.::: :* .* :: ::* **:: . :: .* : . . : : : : * : : : * ::. :*****: : * . : . . ..: . . . : * : : :. * . . : : . ::: . : : . : : : : . .. . . : .. . : .. * : ::.. * :** :. .. . . :*: . *: . . . : . : . *::* : *.*.::.:: : :.: : .** * . . * : **. :* * ..*. :*. :*. * . * .* ", "identical_positions": 121, "similar_positions": 201, "identity": "13.33%" }, { "cls_id": "homologset.agr.HGNC:16871", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BIV7-1", "uniprot_id": "SPRN_RAT", "id": "Q5BIV7-1", "name": "Shadow of prion protein", "aln": "MNWTTATCWALLLATAFLCDSCSAKGGRGGARGSARG-VRGGARGASRVRVRPAPRY---SSSLRVAAAGAAAGAAAGVAAGLATGSGWRRTSGPGELGLEDDENGAMGGNGTDRGVYSYWAWTSGSGSVHSPRICLLLSGTLGALELLRP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BWU1-1", "uniprot_id": "SPRN_MOUSE", "id": "Q8BWU1-1", "name": "Shadow of prion protein", "aln": "MNWTAATCWALLLAAAFLCDSCSAKGGRGGARGSARG-VRGGARGASRVRVRPAPRY---GSSLRVAAAGAAAGAAAGVAAGLATGSGWRRTSGPGELGLEDDENGAMGGNGTDRGVYSYWAWTSGSGSVHSPRICLLLGGTLGALELLRP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5BIV9-1", "uniprot_id": "SPRN_HUMAN", "id": "Q5BIV9-1", "name": "Shadow of prion protein", "aln": "MNWAPATCWALLLAAAFLCDSGAAKGGRGGARGSARGGVRGGARGASRVRVRPAQRYGAPGSSLRVAAAGAAAGAAAGAAAGLAAGSGWRRAAGPGERGLEDEEDGVPGGNGTGPGIYSYRAWTSGAGPTRGPRLCLVLGGALGALGLLRP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1JPW9-1", "uniprot_id": "SPRN_DANRE", "id": "Q1JPW9-1", "name": "Shadow of prion protein", "aln": "MNRAVATCCIFLLLSAFLCDQVMSKGGRGGARGSARGTARGGR--TSRARGSPAVRV----------AGAAAAGAAVALGAGGWYASAQRRPDDSSERGDD------YYSNRTNWELYLARTSGATVHDSTITRLSALLLPINYMMHFAP-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** : *** :** :*****. :************* .*** :**.* ** * *..******.. .** .*. **. ...* * : .* *. :* : : .*:. :* : : ", "identical_positions": 53, "similar_positions": 31, "identity": "35.1%" }, { "cls_id": "homologset.agr.HGNC:16872", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZN5-1", "uniprot_id": "S35B2_MOUSE", "id": "Q91ZN5-1", "name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "aln": "MDA------------RWWAVVVLATLP--------SLG-----AGGESPEAPPQSWTQLWLFRFLLNVAGYASFMVPGYLLVQYLRRKNYLETG-RGLCFPLVKACVFGN-------EPKAPDEVLLAPRTETAESTPSWQVLKLVFCASGLQVSYLTWGILQERVMTGSYGATATSPGEHFTDSQFLVLMNRVLALVVAGLYCVLRKQP-----RHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMMMGKLVSRRSYEHWEYLTAGLISIGVSMFLLSSGPE-------PRSSPATTLSGLVLLAGYIAFDSFTSNWQDALFA----------YKMSSVQMMFGVNLFSCLFTVGSLLEQG--ALLEGARFMGRHSEFALHALLLSICSAFGQLFIFYTIGQFGAAVFTIIMTLRQAIAILLSCLLYGHTVTVVGGLGVAVVFTALLLRVYARGR-KQRGKKAVPTEPPVQKV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7FLA1-1", "uniprot_id": "F7FLA1_RAT", "id": "F7FLA1-1", "name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "aln": "MDAS-----------RWWAVVVLATLP--------SLG-----AGGESPEAPPQSWTQLWLFRFLLNVAGYASFMVPGYLLVQYLRRKNYLETG-RGLCFPLVKACVFGN-------EPKAPDEVPLAPRTETAESTPSWQVLKLVFCAAGLQVSYLTWGVLQERVMTGSYGATATSPGEHFTDSQFLVLMNRVLALVVAGLYCILRKQP-----RHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMMMGKLVSRRSYEHWEYLTAGLISIGVSMFLLSSGPE-------PRSSPATTLSGLVLLAGYIAFDSFTSNWQDALFA----------YKMSSVQMMFGVNLFSCLFTVGSLLEQG--ALLEGARFMGRHSEFALHALLLSVCSAFGQLFIFYTIGQFGAAVFTIIMTLRQAIAILLSCLLYGHTVTVVGGLGVAVVFTALLLRVYARGR-KQRGKKAVPTEPAVQKV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TB61-1", "uniprot_id": "S35B2_HUMAN", "id": "Q8TB61-1", "name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "aln": "MDA------------RWWAVVVLAAFP--------SLG-----AGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYFRRKNYLETG-RGLCFPLVKACVFGN-------EPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQP-----RHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPE-------PRSSPATTLSGLILLAGYIAFDSFTSNWQDALFA----------YKMSSVQMMFGVNFFSCLFTVGSLLEQG--ALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VEI3-1", "uniprot_id": "S35B2_DROME", "id": "Q9VEI3-1", "name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "aln": "MYAYNKMGRVPELVICSFIVVTLLVIHFFSDLLRASLGGYYNQDVTLSQLVESQNSDYAWFLKLLVNCFGYSCVFVPGFLIYKYVGRINYLERGNKTFLHKAINMCITGNSGYDQLDAGTSTADKDRPAASTAPKRTSSQEAVQLLWCFGGLMISYLTWGVLQEKIMTQNY-LNFTGESAKFKDSQFLVFSNRLLAFLVALAYLQWQPSPV----RHRAPLYKYSYASFSNIMSAWFQYEALKFVNFPTQVLAKSCKIIPVMLMGKIMSKAKYESYEYVTALLISLGMIFFMSGSSDS-------SKASGVTTLTGIFLLSMYMVFDSFTANWQGSLFKS---------YGMTPLQMMCGVNLFSSIFTGASLSMQG--GFMDSLAFATEHPKFVFDMVVLSVCSAVGQLFIYHTIDVFGPVVFTIIMTLRQAVAIMLSCFIYQHSISLLGIFGVLIVFVAIFLRVYCTQRLRAIRKRAEANKPKMAV-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12520-1", "uniprot_id": "HUT1_YEAST", "id": "Q12520-1", "name": "UDP-galactose transporter homolog 1", "aln": "------------------------------------------------------------------------------------------------------------------------------------MAGSTSS-----LVICAIGIYATFLTWALVQEPLATRTWPNSMG----KFQFPNVISLIQASVAMMMGYLYLNWKKVEYPPRKMIKDHWKQLMLISFTQSSSGPLATTSLKHVDYLTYMLAKSCKMIPVLLVHLLLYRTPIASQKKVVALLVSLGVTIFTIGGNDGKKLKRSFNESGNDNKLQGFGLLFSSLFLDGLTNATQDKLLKANKAKEKGKQTLITGAHLMFTLNLFVILWNILYFIVIDCKQWDNAVSVLTMDPQVWGYLMLYSFCGAMGQCFIFYTLEQFGSLVLIMITVTRKMVSMILSIIVFGKSVRFQQWVGMFIVFGGITWEALNKKKANIPKAKSA---------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . *. *: * *: ::***.::** : * .: . :* .:.: : : :*:::. : *::: *. :**.*.: * :***:.*:***::: :: : : :.* *:*:*: :* ... .:. ..* *: ** : :*.:* *. *: :: ::* :*:* ::. : . :. . ..:. :: *.*.* ** **::*: **. *: :* . *: .:::** ::: ::: . .*: :** .: .. : . :: ", "identical_positions": 59, "similar_positions": 118, "identity": "12.07%" }, { "cls_id": "homologset.agr.HGNC:16873", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91WF7-1", "uniprot_id": "FIG4_MOUSE", "id": "Q91WF7-1", "name": "Polyphosphoinositide phosphatase", "aln": "------MPTAAAPIISS------------VQKLVLYETRARYFLVGSNHAETKYRVLKIDRTEPK-DLVVIDDRHVYTQQEVRELLGRLDLGNRTKMSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPND-SVRISHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKACQESFDIFEDEGLITQGGSGVFGISSEPYMKYVWNGELLDIIKNTVHR--DWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFT--------AGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHVAALHFDQMLQRFG-SPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGHVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGK--PHLWELPTDFYLHHKNTMSLLPPRRSYTYWWTPEVVKHLPLPYDEVICAANLKKLMVKKFHRWEEEIDIHN----EFFRPYELSSFDDTFCLAMTSSARDFMPK-TVGIDPSPFTVRKPDETGKSVLGNKNTREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKATENVVQP-MKEVYGVSLSSSLSEEDHSIYARFVQLGQSQHKQDRGNQQLCSRCSDGVIKLT------PISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAMYREYIRNRYL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92562-1", "uniprot_id": "FIG4_HUMAN", "id": "Q92562-1", "name": "Polyphosphoinositide phosphatase", "aln": "------MPTAAAPIISS------------VQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPK-DLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPND-SVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHR--DWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFT--------AGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFG-SPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGK--PHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHN----EFFRPYELSSFDDTFCLAMTSSARDFMPK-TVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQP-MKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLT------PISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VR06-1", "uniprot_id": "Q9VR06_DROME", "id": "Q9VR06-1", "name": "", "aln": "-MNNDNPNIVFNPLISS------------IQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHN-RLSIEENANEFNSLEIRRFVASL-------------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVD--YAFRSDSRKRFVWNAYLLQPMEGIMLK--DWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDG---------------QRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYG-APLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMFFKAAGS------------EPG--------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLGFVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMH--NAFVPRADSKAITDWVRHKVRACLPYSCAD---SNKLVKELFRVHSSGLEMIDAYS----NYHQSFKWTDFSEHIAFEISQLALRYMP--TFRTNFSPFQR--------QIQTSRKARQNPSMTGQSSTGSMNSNSS---SSSEGDDSSSD--EELSASFAEKEANQTESTEPAAATLATGLPSMEEIYGCTINP-PSKQSMAVYKKYVQMGKLSSGGARPAQTAVAQRDQELAKIMRGITLRPLSDYGTDSYLSVRPPVVPRKSLTIYAEYCRTRSTFNAVPKLEEFDVLYQYVQKL--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P42837-1", "uniprot_id": "FIG4_YEAST", "id": "P42837-1", "name": "Polyphosphoinositide phosphatase", "aln": "MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEAT--------EDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDR-CDITIPCG----------------------ITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFAS-------------------TKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGF--PSLWEMNTDFYLH--NAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRK-----QSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQE--LELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVS---------VDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :::: : * .****: * ::****: ** :*:* ** . * : :: :. *: ..:. * .* : :.:*::**::* **::::** * ** * :* :.. :: : : . ..* * .:*:::** ..*****:**::.:** * : : :: :*** **. : : **: : *** .* : : *: : : *:**** :***:******.* :*.**********: * ::.* ***:* .*:** *.: .** * :: **: .:***:.:: ::* ..: :***:* :*: :* : *: .: ***:***. : : : :**:: :: . .*:: * * . * **:* : .. :* ** *:**:*******:*** :** **. ** **::... *::*:* * :: :*:.: ***::******:**: ::**** * .:. *:::::.*:***:* *:::*.:****** : * :**: **: :* *: :: * : : : : . .. ::. . . : : : :. :.. . . . *** . .: . :.: . :. .:* :: : :. . : : :. : :. : .: : :.:: . . : :. . . . .* : : : : : : ", "identical_positions": 199, "similar_positions": 254, "identity": "20.9%" }, { "cls_id": "homologset.agr.HGNC:16874", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63564-1", "uniprot_id": "SV2B_RAT", "id": "Q63564-1", "name": "Synaptic vesicle glycoprotein 2B", "aln": "---------------MDDYR---YR----DNYEGYAP--NDGY-YRGNEQNPEED----AQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLRGQADLMAER-------------MEDEEQLAHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPK-QMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGITKVVPILLAAASLVGGGLVALRLPETREQVLM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BG39-1", "uniprot_id": "SV2B_MOUSE", "id": "Q8BG39-1", "name": "Synaptic vesicle glycoprotein 2B", "aln": "---------------MDDYR---YR----DNYEGYAP--SDGY-YRSNEQNQEED----AQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLGGQADLMAER-------------MEDEEELAHQYETIIDECGHGRFQWTLFFVLGLALMADGVEIFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPK-QMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFINCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7L1I2-1", "uniprot_id": "SV2B_HUMAN", "id": "Q7L1I2-1", "name": "Synaptic vesicle glycoprotein 2B", "aln": "---------------MDDYK---YQ----DNYGGYAP--SDGY-YRGNESNPEED----AQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAER-------------LEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPK-QMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "X1WCQ3-1", "uniprot_id": "X1WCQ3_DANRE", "id": "X1WCQ3-1", "name": "", "aln": "--------------MADPYQNNIYHQGDGDSYGTYGQGGQDGYGYQTDYPPQEED----AASDATEGHDEDDQMYEGEYQGIPHPDEVKAARR--------AARAKARTPTDT-------------VSELEELAEQYEDIMEDCGHGKFQWTLFVVLGLALMADSVECFVVALVLPSAEKDMCLSHAEKGMLGLIVFLGMMFGAFIWGGLADKVGRRKCLIIVLAMNCISAFFSSFAQGYGFFLFFRLFSGIGIGGSVPIVYSYFSEFLQMDKRGEHLSWLCMFWMMGGIYASFTAWGIIPRYGWGFSMGTEFQFHSWRVFVLVCALPAIAAFVGLMFMPESPRFLLENAKHDEAWMILKQVHDTNWRAKGQPEKVFTVTQIRTPKTQEDEFIEIQTATGTAFQRWVVRTLTLTKLVIKNVLSLFGRELRLATLLMAIIWFTMAFSYYGLSVWFPDMIKHLQHEEYESKVKVFHREKVEQFHFNFSLENQVHKEGEYINDKFINIEMKSVKFEDSLFVDCFFENVRSTETMFENCTIRSTVFYDTDLYEEKFIDCTMENVTFLHNKKGCHLDYEEDNDVLIYLVSFLGSLAVLPGNIISALFMDKIGRIKIIGGSMLVSAGCTFFLFLSFSQAAIIAWQCLFYGVSVAAWNGIQVITVELYPASKRATAFGFLNAMCKLAAILGSSIFASFIGITKVIPILLSFAALVSGGVLALKLPETREKVLM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W3W9-1", "uniprot_id": "Q9W3W9_DROME", "id": "Q9W3W9-1", "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "aln": "MVEGDSAKGKSEFYNVEAGLQPNYNQSAASNQASNHPTGQANAPATGNATSHIDNRAIIQPYSLGTGPKQPEYQFAADNRGYEPDSHANGKQQDVERDAPDGGHGGHGPPGKGGKGGKGRKKSVPLPEPTAPIVANFERAIELCGYGKFHYILLAICGLVSTSEEMDVISMSFILPSAECDLDLNTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRT-IGFTT-PYFTYNSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYDLEVD-------EKLLESNGNVKNKYSRMIS-------GMVDHSRALFKSPILRFTIVSITINFTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKE--------------------------------------------------------------------------QSNNGTCSSDIPQS----VFMESLISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVSAIFSGAISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLPNTTRKELN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *. .. . . : :: . * .: : : .: :* ...:. : . . . . :. ::* :: **:*:*:: *: : *. :: :: : ::: ***** *: *. ** *. *:::*** **:: *.:**..**:: * : :*. *** * *. *:: *::.* .:**: *::::**:** ***. **:: ** *.::.: ** ***: **: . : ::***:*::**:**. . * ::****:*** .*:*.* *:: :. ** : : *: : ::::* : . . :.* : : .: . *:: : *:: :.**** :***:::. ::. * : * .*:: * :: * * :. ::: *::. :.**.*::: * ** :** :: .. : :. * :::: *. : ..:* *. ** .:: : .*::*:. ***...: .::..*:*. ::*.::. * :: . *:.**::.* **:* .: * ", "identical_positions": 135, "similar_positions": 217, "identity": "18.6%" }, { "cls_id": "homologset.agr.HGNC:16875", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q64449-1", "uniprot_id": "MRC2_MOUSE", "id": "Q64449-1", "name": "C-type mannose receptor 2", "aln": "---MVPIRPALAPWPRHLLRCVLLLGGLRLGHP-ADSAAALLEPDVFLIFSQGMQGCLEAQGVQVRVTPVCNASLPAQRWKWVSRNRLFNLGATQCLGTGWPVTNTT---VSLGMYECDREALSLR--WQCRTLGDQLSLLLG--ARASNASKPGTLERGDQTRSGHWNIYGSEEDLCARPYYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPGEENCGVIRTESSGGWQNHDCSIALPYVCKKKPNATVEPIQPDRWTN-VKVECDPSWQPFQGHCYRLQAEKRSWQESKRACLRGGGDLLSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGRLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVIYSDARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFRWLSGDEVIYTHWNRDQPGYRRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWVSDPKLRHCYKVFSSERLQEKKSWIQALGVCRELGAQLLSLASYEEEHFVAHMLNKIFGESEPESHEQHWFWIGLNRRDPREGHSWRWSDGLGFSYHNFARSRHDDDDIRGCAVLDLASLQWVPMQCQTQLDWICKIPRGVDVREPDIGRQGRLEWVRFQEAEYKFFEHHSSWAQAQRICTWFQADLTSVHSQAELDFLGQNLQKLSSDQEQHWWIGLHTLESDGRFRWTDGSIINFISWAPGKPRPIGKDKKCVYMTARQEDWGDQRCHTALPYICKRSNSSGETQPQDLPPSALGGCPSGWNQFLNKCFRIQGQDPQDRVKWSEAQFSCEQQEAQLVTIANPLEQAFITASLPNVTFDLWIGLHA-SQRDFQWIEQEPLLYTNWAPGEPSGPSPAPSGTKPTSCAVILHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAATPPAPGAELSYLNHTFRLLQKPLRWKDALLLCESRNASLAHVPDPYTQAFLTQAARGLQTPLWIGLASEEGSRRYSWLSEEPLNYVSWQDEEPQHSGGCAYVDVDGTWRTTSCDTKLQGAVCGVSRGPPPRR-INYRGSCPQGLADSSWIPFREHCYSFHMEVLLGHKEALQRCQKAGGTVLSILDEMENVFVWEHLQTAEAQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSSSGLWRPGACTNITMGVVCKLPRVEENSFLPSAALPESPVALVVVLT-AVLLLLALMTAALILYRRRQSAERGSFEGARYSRSSHSGPAEATEKNILVSDMEMNEQQE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4TU93-1", "uniprot_id": "MRC2_RAT", "id": "Q4TU93-1", "name": "C-type mannose receptor 2", "aln": "---MGPIRPALAPWPRHLLRCVLLLGGLRLGHP-ADSAAALLEPDVFLIFSQGMQGCLEAQGVQVRVIPVCNASLPAQRWKWVSRNRLFNLGAMQCLGTGWPATNTT---VSLGMYECDREALSLR--WQCRTLGDQLSLLLG--ARANNASKPGTLERGDQTRSGHWNIYGSEEDLCARPYYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPGEENCGVIRTESSGGWQNHDCSIALPYVCKKKPNATAEPIQPDRWAN-VKVECDPSWQPFQGHCYRLQAEKRSWQESKRACLRGGGDLLSIHSMTELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGRLSQGTAEEDHGCRKGWTWHSPSCYWLGEDQVIYSDARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFRWLSGDEVMYTHWNRDQPGYRRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWVSDPKLRHCYKVFSSERLQEKKSWIEALGVCRELGAQLLSLASYEEEHFVANMLNKIFGESEPENHEQHWFWIGLNRRDPREGHSWRWSDGLGFSYHNFARSQHDDDNIRGCAVLDLASLQWVAMQCQTQLDWICKIPRGVDVREPDIGRQGRLEWVRFQEAEYKFFEHHSSWAQAQRICTWFQAELTSVHSQAELDFLGQNMQKLSSDQEQHWWIGLHTSESDGRFRWSDGSVINFVSWAPGKPRPIGKDKKCVYMTARQEDWGDQRCHTALPYICKRSNSSGETRPHDLPPSTLGGCPSGWNQFLNKCFRIQGQDPQDRVKWSEAQFSCEQQEAQLVTIANPLEQAYITASLPNVTFDLWIGLHG-SQRDFQWIEQEPLLYTNWAPGEPSGPSPAPSGTKPTSCAVILHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAAALPAPGTELSYLNRTFRLLQKPLRWKDALLLCESRNASLAHVPDPYTQAFLTQAARGLQAPLWIGLASEEGSRRYSWLSEEPLNYASWQDGEPQHTGGCAYVDVDGTWRTTSCDTKLQGAVCGVSRGPPPPR-ISYRGSCPQGLADSSWIPFREHCYSFHTELLLGHKEALQRCQRAGGTVLSILDEMENVFVWEHLQTAETQSRGAWLGMNFNPKGGMLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSSSGLWRPGACTNVTMGVVCKLPRVEENGFLPSAALPENPVALVVVLTAAVLLLLALLTGALILYRRRQSAERGSFEGARYSRSSRSGPAEATEKNILVSDMEMNEQQE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UBG0-1", "uniprot_id": "MRC2_HUMAN", "id": "Q9UBG0-1", "name": "C-type mannose receptor 2", "aln": "---MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTT---ASLGMYECDREALNLR--WHCRTLGDQLSLLLG--ARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWAN-VKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHA-SQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQSSFSP-SALPENPAALVVVLM-AVLLLLALLTAALILYRRRQSIERGAFEGARYSRSS-SSPTEATEKNILVSDMEMNEQQE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A286YBI9-1", "uniprot_id": "A0A286YBI9_DANRE", "id": "A0A286YBI9-1", "name": "", "aln": "MHHQHRERRWSRAWISVCRCTLYLFLVLSLERS-AVHSAHTDGSDTFAFFHEGAQGCLGVRDHVLHLSSSCKG--EAQLWKWVTRSRLFNIGSSLCLGITVGNVSTFGDRSPLGVFRCDYEPPRVRWTWSCSKFLETLETHLASPKLLLNSGNVSTTAR-PPSKKLLWRVYDNQ-DLCAKSYREIYTIRGNSHASPCYFPFLYNGQWFHSCTSVGREDGFHWCATTHDYGKDQRWGFCPIKSADCETFWDINSLMDNCYQFNFQATLSWSEARTSCQQQGADLLSITKVEEQIYVNGLLIGYSATLWMGLNDLDLNGGWQWADSAPLKYLNWEAEMPSYDEEENCGVISTDAQGRWHNRDCSVALPYICKKRPNATLDPFTTDSWADDGHYQCDVGWQNFQTGCYWLNSDKLDWRSADRTCQKMEANLVSIHTLPELEYITKHMKKDIEELWIGLHDTAMQMNFEWTDRTPVIFTYWHPFEPNNFREVNEDCVTIWGPEGRWNDSPCNYSLPSICKKPAQKAD-DRIQDHGCKRGWKWHSPSCFKVGEESLTFKDAKEMCISNNATLAIINNRFEQAFVSSLVFGRTDDQFWLGLNNENSSGTFGWITGDELTYTNWNRDQPAQVKGGCVVMVAGQAMGLWEVKDCASIRSKYICKQNQGSSSIPSPPAPVPTPSLTGSCPSGWKSSNSFRHCYKVFHAGALEKRLTWIQAHKFCQKHGAQLASFSTPEEEAFVFQILHEAFG--EAEEHEQHWLWIGISRRNS---DSWTWSDGSAVTYQNFGRGNYGS---AECGAANMADTNWLVSHCESELDWICKIPKGKVEEEPESHEDTGLEWVDFEEAQYKMFEHRSTWDQAQRICSWFEASLVSMHSPKENQFLVSTLRKMSRQENDLWWVGLHTFKNDGRFRWSDHSVLNYVSWGPGQPRPISKETKCVQISASKGDWSDQRCHVDLPYVCKRVNVTGTIPPTPSLPLTPAGCPQGWTPFLHKCYKVFGEELSSRSTWDAASKTCLTQRATLVTVPNHRVQAFLVTLLPNSSFHLWVGLTSESQAQFKWFEPGFLSYTNWAPGEPVDNKQMKS---PGNCVLLLHGSPQRITGMWASRRCDAEKHGFICMKDKDPALSPGVDRLPPSLDGPLEFDGVQYRILQKRLDWHSALQVCESVNGTLAAVREPRQNAYLTLLLSTLRKPAWIALHNE-GGRSYSWLGEEEITFSDWRDGEPNQMYGCGHMITEGQWTVAACNSKLNAAICEMNTETTKEHRWMYPGVCPQPVGNWSWIPFRNHCYSFILHELQFKQEAIRMCSKVGAKLLSILDENENGFVWEHMQSFQHQAHGAWLGMIFNSKEGSLEWSSGEIVDYSNWEQQDANLSMLSANSCFWVKSNTGLWRPESCKNRTHGVICKRPRGP--TAEPVNSSEVDHLHVLIQVLVAVLVLMALVVGGVYLYRRRSFGSTGAFESARYSRTN-STPSEEAEKNILVSDMELNEQGE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .* : *: * * :. * * .:.* :* .* **** .:. ::: . *: ** ****:*.****:*: *** ..* .**::.** *. :* * * .: : *. *. * .: .* * ::. *.:*..: **** .* *:***:****..** :** *:.****.***.*****. *****:*****:********* ******* :.* *.*******:**** ** :**:**********::.** *:**** ***:***:****** .*****:*.:********:: *. ******* *::.* *:*:***:****:***:**** :* .* *:: : :*: .** ** ** *:::* .*:.:.::* : .:*:***::.***:***::*:::*******:* :******:* : * **:**********: ******************* ********..: :: :****::**.******: :**:.: :.:*:.:* .:.: *. *.***********::. .: ** .*:: **:*:* *::***: **:******. :****.:.:*.********:*:*:*::***:*. *:. *. *.* **********.** *. .:*:***** : *:.: :*::* *:: **** *::: *** ** ::*:: ** *.* *****:***:.**:. .** **** ..:*:** *..:.. *.. ::*. :*: :*:::********:* .**: : **: *:**:**:***:*:* ******:**:*.*.*:** * :** .::*:* ::: **:**** :.******:* *::*::**.**:***:.*:.*** ::* : **.**** . ***:*** * : * . : .***..* **:**::: *:: ..* .*. *. :* *.* ***:.* **::.: *** :*.**:** . ** :*:*.* * *:******* . . * * .*.::**... ::** * .* * *.***** *..**:***. *: . *.: . :*:*** * *:.** :*** *.:** * :* :*:** *: * **.* .* *.* ***:.** :.: .*:* **:: ** :: .:* * .::*::**:.*:* :. .. : * * *** :.: :*****:***** . * ::** : *.:.*. :****** ** *****:*: : *::****** **.* * * *... *:**** . . **** ***:*::*.:***** :*.* * **:** ** * : . ::: : ***:*:**:...: *****. . *:**.*****:. * *:* :**********:*** *", "identical_positions": 708, "similar_positions": 423, "identity": "47.39%" }, { "cls_id": "homologset.agr.HGNC:16876", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q78E60-1", "uniprot_id": "ARNT2_RAT", "id": "Q78E60-1", "name": "Aryl hydrocarbon receptor nuclear translocator 2", "aln": "MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRR-SGMDFDDEDGEGPSKFS---------------RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMS--IPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEYVICTNTNVKQLQQQQ-AELEVHQRDGLSSYDLSQVPVPNLPTGVHEAGKPVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGKAFSSSVVHVPGVNDIQSSS-STGQNISQISRQLNQGQVAWTGSRPPFPGQ-----PSKTQSSAFGIGSSHPYPADPSSYSPLSSPAASSPSGNAYPSLANRTPGFAESG---QSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61324-1", "uniprot_id": "ARNT2_MOUSE", "id": "Q61324-1", "name": "Aryl hydrocarbon receptor nuclear translocator 2", "aln": "MATPAAVNPPEMASDIPGSVALPVAPMAATGQVRMAGAMPARGGKRR-SGMDFDDEDGEGPSKFS---------------RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMT--IPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTFQNPYSDEIEYVICTNTNVKQLQQQQ-AELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGKAFSSSVVHVPGVNDIQSSS-STGQNISQISRQLNQGQVAWTGSRPPFPGQ-----PSKTQSSAFGIGSSHPYPADPSSYSPLSSPAASSPSGNAYPSLANRTPGFAESG---QSGGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HBZ2-1", "uniprot_id": "ARNT2_HUMAN", "id": "Q9HBZ2-1", "name": "Aryl hydrocarbon receptor nuclear translocator 2", "aln": "MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRR-SGMDFDDEDGEGPSKFS---------------RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMT--IPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQ-AELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSS-STGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESG---QSSGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9DG12-1", "uniprot_id": "ARNT2_DANRE", "id": "Q9DG12-1", "name": "Aryl hydrocarbon receptor nuclear translocator 2", "aln": "MATPAAVNPSEMGTDLPGPVSMPGAVVGA-GQVRMTGAMPGRGGKRRSAGMDFDDEDGEGPSKFSRYDDDQIPGDKERYARENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNTSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNHPQSEWFGSTLFEQVHPDDVDKLREQLSTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSAPLDHISLNRLSSMRKRYRNGLGPSKEGEAQYSVVHCTGYIKAWPPAGMT--IPDEDTEAGQTSKYCLVAIGRLQVTSSPVSMDMNGLSVPTEFLSRHNSDGIITFVDPRCINVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRMKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQQAELEVHQRDGLTAYDLSQVPVSGVSAGVHESGKTIDKTESLFSQERDPRFSDIYTGISTSEKKMMVPSSTSGGQQLYSQGSPFQPGHSGKSFSSSVIHVPGVNDIQSTAGSAGQNLSQISRQINTGQVSWSGNRPPFSGQQIPAQSNKAQSSPFGIGSSHSYQADPSSYSPLSSPATSSPSGNAYSNLANRNTAFDVSGESSQSGGQFQGRPSEVWSQWQSQHHSQQAGDPHPHTQASQTEVFQDMLPMPGDPTQGTTNYNIEDFADLGMFPPFSE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O15945-1", "uniprot_id": "ARNT_DROME", "id": "O15945-1", "name": "Aryl hydrocarbon receptor nuclear translocator homolog", "aln": "----------------------------------------------------MDEANIQDKERFAS--------------RENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQ--RNSLGPSRDG-TNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTST-AANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTMHGAP--------LDAAAAHTPEQVQQQQQ----QEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSP--YSAGGPS-PLAKIPKSGTSPTPVAPNSWAALRPQQQQQQ---QQPVTEGYQYQQTSPARSPSGP-TYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPG--MWDWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAGQP-QGQEFSDMLQMLDHTPTTFEDLNINMFS-----TPFE-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*: : :. .:*: ****.*********** *****************************:***::*****.*:**:*******:******************:.::*************** .**:*:*::*:*::**** :*:****.*.*.. :*******:*******:*****:.**:**.****** *.. : : .::. ::: **.*** ::* ::*:********* ***:.* : * . *: ************: .. **.* . :**::** ** :**** * :.::** * :**** :* *******::***:**:* ***::*::** * ** *:: :**.:::* ***:**:**::***:. * :: *. ::: .** :* :: : .: .*: :. . :.:*: :.: ** .* * . : .:: .. * * . ..: . .: .. : . :*:. ** * ::. : :. :.* :*: **: . ..:. . *. . .* . * *:* . :.:* :.* *. * : *.*** * .... : **: *: .**. ", "identical_positions": 276, "similar_positions": 186, "identity": "37.3%" }, { "cls_id": "homologset.agr.HGNC:16877", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80U63-1", "uniprot_id": "MFN2_MOUSE", "id": "Q80U63-1", "name": "Mitofusin-2", "aln": "---MSLLFSRCNSIVTVKK----DKRHMAEVN----------------------------------------ASPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDPVTTEE--------------------------------------------------QVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHE------------AFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGS----MVSVMWPNSK----CPLLKD---DLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWD-ASASEPEYMEEVRRQHMERCTSFLVDELGVV---DRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERQFEECISQSAVKTKFEQHTVRAKQIAEAVR-LIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLS-VLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNLSDRCSTAIASSLQTMQQDMIDGLKPLLPVS--MRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKN-----------SRRALLGYSDQVQRPLPLTPANPSMPPLPQSS-LTQEELMVSMVTG---LASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSRAKLLRNKAGWLDSELNMFTHQYLQPSR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8R500-1", "uniprot_id": "MFN2_RAT", "id": "Q8R500-1", "name": "Mitofusin-2", "aln": "---MSLLFSRCNSIVTVKK----DKRHMAEVN----------------------------------------ASPLKHFVTAKKKINGIFEQLGAYIQESAGFLEDTHRNTELDPVTTEE--------------------------------------------------QVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHE------------AFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGS----LVSVMWPNSK----CPLLKD---GLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWD-ASASEPEYMEEVRRQHMERCTSFLVDELGVV---DRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVR-LIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQMTEEVERQVSTAMAEEIRRLS-VLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVS--VRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKN-----------SRRALLGYNDQVQRPLPLTPANPSMPPLPQGS-LTQEELMVSMVTG---LASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTRAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSKAKLLRNKAGWLDSELNMFIHQYLQPSR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O95140-1", "uniprot_id": "MFN2_HUMAN", "id": "O95140-1", "name": "Mitofusin-2", "aln": "---MSLLFSRCNSIVTVKK----NKRHMAEVN----------------------------------------ASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEE--------------------------------------------------QVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHE------------AFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGS----LVSVMWPNSK----CPLLKD---DLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWD-ASASEPEYMEEVRRQHMERCTSFLVDELGVV---DRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVR-LIMDSLHMAAREQQVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLS-VLVDDYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLPVS--VRSQIDMLVPRQCFSLNYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKN-----------SRRALMGYNDQVQRPIPLTPANPSMPPLPQGS-LTQEEFMVSMVTG---LASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQPSR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BJP0-1", "uniprot_id": "A0A8M2BJP0_DANRE", "id": "A0A8M2BJP0-1", "name": "", "aln": "---MSLVFPRPNTSVIGKK----DKRLMAEVN----------------------------------------ASPLKHFVTAKKKINGIFEQLGAYIKESSAFLEETYSNEELDPVTTEE--------------------------------------------------QVAEVRGYLSKVAGIGEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVEGTDGNE------------SFLLTEGSDERKSVKTVNQLAHALHQDEDLDAGS----LVCVMWPKAK----CALLRD---DLVLVDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWD-ASANEPEYMEEVRRQHMDRCTSFLVDELRVV---DRSHAGDRIFFVSAKEVLQARVQKAQGMPEAGGALAEGFQARMFEFQNFERRFEECISQSAVKTKFEQHTTRAKQISEALR-LIMDSVHIAAQEQRIHCLEMKEEREDRLEFIDKQLDLLTLDCKSKIKKITEEVEKQVSNAMAEEIRRLA-VLVDDFHMDFHPSPVVLKVYKNELHRHIEEGLGRNMSERCSSAITVALQTTQTDMIDGLKPLLPIT--IREQVDKMVPRQCFALSYDLNCDKLCSDFQEDIGFHFSLGWTMLVNRFLGPKN-----------TRRALMGYNDQVPRSLAITPVSTSMPPFPQGS-MTQEELMVSMVTG---LASLTSRTSMGIIVVGGVIWKAVGWRLIALSVGLYGLLYVYERLTWTTRAKERTFKRQFVDYASEKLQLIVSYTGSNCSHQVQQELASTFSQLCQQVDVTRQQLEDEIGDLNSKIEQLDTLQSKAKLLRNKAGWLDSELNMFIQQYLQQGR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7YU24-1", "uniprot_id": "MARF_DROME", "id": "Q7YU24-1", "name": "Transmembrane GTPase Marf", "aln": "---MAAYLNRTISMVTGQTGPADDDRHASSTDTVDKSGPGSPLSRFNSSLQQSGSTMAANLLPESRLYQSNDKSPLQIFVRAKKKINDIYGEIEEYVHETTTFINALH--AEAEIVDKAE--------------------------------------------------RELFES-YVYKVAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGE------------AYLMTEGSEEKLNVVNIKQLANALCQEK-LCESS----LVRIFWPRER----CSLLRD---DVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWD-ASANEPECQESVKSQHTERCIDFLTKELKVS---NEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQHSSRGKSVSGDMK-SMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLG-VLIDEFNMPFHPERLVLNIYKKELNAHVESGLGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAPVVAGITPEQLSLISRFA---VSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYISPQ-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "O18412-1", "uniprot_id": "FZO_DROME", "id": "O18412-1", "name": "Transmembrane GTPase fzo", "aln": "-------MAESDSGESTSS----VSSFISSSS----------------------------------------SSRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDRQ--------------------------------------------------------MLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNE------------TEHVKVEQEDEHMELSALSQLASAHSPGALKPST----LLQVNMAKNR----CSILDY---DVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCVNLLVDELGVYS--TAQEAWERIYHVSALEALHIRNGQITNP-------SGQTQQRYQEFLRFENDFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHP---EFPAQIGQYQRSLCAHLDKLLEDRVLQCLSIPLQRKILDIEKEIGLPIAEN------------SCDWQLIYGLDCQSYMSDFQPDLRFRFSLGFTALWHRLEGNLP---------------LHASPFRIQKLQNGHKKCSPLPPLVNGN---------HWQML---ESLVKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNVRTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38297-1", "uniprot_id": "FZO1_YEAST", "id": "P38297-1", "name": "Mitofusin FZO1", "aln": "MSEGKQQFKDSNKPHKDSTDQDDDAATIVPQTLTYSRNEGHFLG------SNFHGVTDDRTTLFDGEEGRREDDLLPSLRSSNSKAHLISSQLSQWNYNNNRVLLKRSILKTQAFMDQLQEENNIRPIFIAANDEREKLHVLQLNIKLDGQYNTKEKNGFNIEKKALSKLFHSQIVSVTNHLNALKKRVDDVSSKVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFSEILEARENDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKELPDLVPQNGKYALLKIYIKDDKRPASTSLLRNGTVDISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAENQLTLSAKEFISLASR--EKKLMFFVVKKFD-------------KIRDKQRCKELILKQIRDLSPETYKRAADFVHFVSKNGDELPHYHNENDNEDHGDRKPDDDPYSSSDPDPDFDSLEDSLRNFVLKKRSLSKLLPAK--------TYLSKLLSDIIMISKSNMKMYSEEEIKINEQLETLRPEILSARAKCNDLTTSVDQMAEQTITMTYNNTKEALLNALDVPLHEYPKYQGLGQIYDFIFSTEAFIANQIDESIGSSELFAKQKTDLLVKKIYEIGKNE-----LGDDFMCERVFRSELMFRKRKHLIGKRLKVSLSITDLFAPTWKGFLSYLSWQKP-------VTAPLPDIEGQTNEGQIGLMKYLGLKNYPLTQYWSRPSLLFTSKIPTLTLYFLGSTKVVGNIILNGIKLSSWSSLKKLSVPVIVVGSLLGLTYLIHDLPRALPMNLSIKYKRKLQELDYIHLNAQRTSNEVRDVLRVPTREILRSCEIIMDKKQITKKELE---NKKESNLLSIKFFQSLYEGTVAQKLMVEEINLDID-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . .. . * : ::.: : * :: : : .: :: .: : : ** : * ...***:: *::* :::**. *. * .: : : :. : : . * . :: : : .:* .: ::*:**::: : : . : *:.::* *:*. : : *: . . :*:: :::* : :. :** .:: .:: .* : :..** : : . . : :.:.: .:*.: : .: : . . .:. : : ..:. .:. .: : :* : . . : : . : : : . . : .: : :: : : : . : : * :* ::: .: : . : : .: .:: . : : . . :::: * : . : : : : * ::. . . . : ", "identical_positions": 37, "similar_positions": 192, "identity": "4.11%" }, { "cls_id": "homologset.agr.HGNC:16878", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AMR5-1", "uniprot_id": "A0A8I6AMR5_RAT", "id": "A0A8I6AMR5-1", "name": "ATP-dependent RNA helicase with zinc finger domain", "aln": "----------------------------MEDRRAERSCEQACASLQRQD-YDMALQHCTDALLSLGQYS----------------------------------------------MTDFAGPCPVEIERIKIESLLYRIASFLQLKNYGQADEDCRHERGS----------------RFDSQHPRDGSNFLLGEGLAKGESAFRAVLCCMQLKG--------KLQPVSSILAQSLSGESLNGMVTKDLTRLKTLLAETETATSNAPSGCHVEDLDEGSCNG---------------------------------WHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECLEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLCRVALLYDAHRPHFSIIAISAGDSTAQVSQEVPEN-CQEWIGGEMAQN-----GLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTT-ARRWEPSSKTIVDFEPNE-----------TTDWEKSLLIRYQIPLSADQLFTQS-VLDKSLTKTNYQSRLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGG---AKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQ--GTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLCIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNAQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRAFRLQHS--GNSSRQQQSPPKVKSLHHPQNDHFQND---GIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTG--YQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVNLGQPQNQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPK--QIDLESNPQNRSP-ESRPGVVYSNTKFPRKDNLNPRHIN-LPLPAPHTQYAIPSRHFHPLPQLPRPPFPISQQHTLLNQQQNNLPEQPNQMTPQPNQVAPQPNQMAPQPNQMAPQPNQVVQQQNQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQQVPPGLSDGHS-PLRAITQPGPILASPLNNFVDESSPGLPIEEALDRVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLAHLPQTPISLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQ-GDTGELAEMPPPQSRLLQYR-QVQPRSPPAVPSPPSSTDHSSHFANFNDNSRDIEVANSPAFPQRLPPQLFGPPYSLQSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAVGQEPFHPLPSRAVSSSSLPSLEEYEPRGPGRPLYQRRISSGAAQPCVEEASTPQDSLAQGKEPQDHSNPPGFGFPAPESWAN----TTSSAPYQNIPCNGSSRTSQPRELIVPPKTVKP--PEDQLKPDSGEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSQQSPAGSK--PAMSYASALRAPPKPRP-PPEQAKKGSDPLSLFQELSLGSSPGSNGFYSYFK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6DFV5-1", "uniprot_id": "HELZ_MOUSE", "id": "Q6DFV5-1", "name": "ATP-dependent RNA helicase with zinc finger domain", "aln": "----------------------------MEDRRAERSCEQACASLQRQD-YDMALQHCTDALLSLGQYS----------------------------------------------MADFTGPCPVEVERIKIESLLYRIASFLQLKNYGQADEDCRH---------------------------------VLGEGLAKGERAFRAVLCCMQLKG--------KLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETATSNVLSGCHVEDLDEGSCNG---------------------------------WHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPEN-CQEWIGGKMAQN-----GLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKRQLVTT-AKRWDSSSKTIVDFEPNE-----------TTDLEKSLLIRYQIPLSADQLFTQS-VLDKSLTKTNYQARLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGG---AKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQ--GTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDIQVELQFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAAKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEPGFFTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHS--GNSSRQQQSPPKVKSLYHPQSDHFQSD---GIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTG--YQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPK--QVDLESNPQNRSP-ESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPHAQYAIPSRHFHPLPQLPRPPFPASQPHTLLNQQQNNLPEQPNQMAPQPNQVAPQPNQMTPQPNQVAPQPNQVVQQQSQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQPPPPGLPDGHS-PLRAITQPGPILASPLNNFVDESSPGLPIEEALDGVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLPHLPHTPIGLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQ-GDTGELAEMPPPQSRLLQYR-QVQPRSPPAVPSPPSSTDHSSQFANFNDSSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAAGQEPFHPLSSRTVSASSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASAPQDSLAQGKESQGHSNPPAFNFPAPESWAN----TTSSAPYQNIPCNGSSRTSQPRELIAPPKTVKP--PEDQLKPESGEVSSSFNYSMLQHLGQFPPLMPNKQIAESANCSSQQSPAGSK--PAMSYASALRAPPKPRP-PPEQAKKGSDPLSLLQELSLGSSPGSNGFYSYFK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P42694-1", "uniprot_id": "HELZ_HUMAN", "id": "P42694-1", "name": "ATP-dependent RNA helicase with zinc finger domain", "aln": "----------------------------MEDRRAEKSCEQACESLKRQD-YEMALKHCTEALLSLGQYS----------------------------------------------MADFTGPCPLEIERIKIESLLYRIASFLQLKNYVQADEDCRH---------------------------------VLGEGLAKGEDAFRAVLCCMQLKG--------KLQPVSTILAKSLTGESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNG---------------------------------WHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPEN-CQEWIGGKMAQN-----GLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTT-AKRWDSSSKTIIDFEPNE-----------TTDLEKSLLIRYQIPLSADQLFTQS-VLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGG---AKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQ--GTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHS--GSTNKQQQSPPKGKSLHHTQNDHFQND---GIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTG--YQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPK--QVDLESNPQNRSP-ESRPSVVYPSTKFPRKDNLNPRHIN-LPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPN---------------------QIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHS-PLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQ-SETRELAEMPPPQSRLLQYR-QVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVN----TTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKP--PEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGK--PAMSYASALRAPPKPRP-PPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NYU2-1", "uniprot_id": "HELZ_DANRE", "id": "Q6NYU2-1", "name": "ATP-dependent RNA helicase with zinc finger domain", "aln": "----------------------------MEDRRPQKSCDEAIGSLVRQE-YEAAVAHSTEALLAMGPRT----------------------------------------------PTPST-------ALLRTRALLYRIAARLQLKDYDQADEDCKH---------------------------------VFAEELAKGDGSFRAGLQSLLLDG--------SLQEVCSVLSKALYGEPLNGIMTKDMTRLKRLLSEIEAARSKVVFS---EENEEDVQEG---------------------------------WQFRPPPRGVTSSEEYTLCKRFLEQGLCRYGAQCTSAHSQEELTEWQRRYASRLIRLKQQQEGKHFSENYMEALIEKWINSLTPERVMNDCVDGVTVEHSSDLSITVNTKKSSHSWTFTLFCKPVRTLQRIALLYDANRPHFSIAAVSAGDASALEPQPVCPGGCQEWSAASPVQN-----GMDHCIYTVEIAFSTEIFGTFRQTVVFDLGCEPVLMQRVMVDAASIEDLEHLLQARQQLLMT-AKRWDSSCKTIVEFVPNE-----------NMDLERSLLTRYQIPLSADQLFTQS-VLDKTLTRDNYQPRLHDLLYIEEIAQYKEVTKFNIKVNLQLVTSFMLTGISGG---AKYAQNGQLFARFKLTETLSEDTLAGRLVMTKVNSVLLLPVFKERMGQNQPAGAKERVYEALIEEKTKDYIFLRVCKECCDELGLVADQELQVELQFQLNRLPLCEMHYALDRVRDNSILFPDISLTPTIPWSPNRQWDEQLDPRLNAKQKEAILAITTPLSINLPPVLIIGPYGTGKTFTLAQAVKHILKQPESRVLICTHSNSAADLYIKDYLHPYVEAGNPHARPLRVYFRNRWVKTVHPLVQQYCLISGAHFTFQMPTRQDVERHRVVVVTLSTSQYLCQLDLEPGIFTHILLDEAAQAMECETIMPLALAVKSTRVVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPSEYPCRILLCENYRSHEAIINYTSDLFYEGKLMASGKQPPHKDFYPLTFFTARGEDVQEKNSTAYYNNAEVFEIVERVEEMRKKWPVSWGKLEEGSIGVVSPYADQVFRIRAELRKKRMSEVSVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTAIKRKEQLVEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSVGRCRKFWETFISICHENHSLHGITFEQIKIQLEALELKKTYVLNPLAPEFIPRALRSQHPPQQGPGKHQHSPPKAKGQLANHTEPFPPE---GFVQPNAAVLMGNPIQAFTPPGAGAPAS--GKSPSPVQRLDP--GASILYVPAVYGGNMVMPMPLPLPWAG--YQSRFPMDPRIMSHQAAM-YNLNLRPAASRTSPVLYGFSHASPLGLNQQQNTEKELLQ-EPSGNGKMDING-KAEHCRLLTPERKAPELKEKQGDLES-VQNKSP-EPQSNMGFPANRLIRKDPQ--RALN-----------------FHMAP--PHPAFPSHHGTSQFPQQYG-----------------------------LSRPP---LRMQTPMHPQASSFPPSFYSGPPMGP----------RGLQSPVLEGG--EDPMGAGMSEDLKGVVRGLPAQMHQQPLRLNSFGEESLDSL-LGDTLDGQASSGMDALQHQQQARVGQWGEHTPFLPAGVAPFPLPQQ--LAHLAQPGLRIPPQILRAGWGLGPAADEEPRPTMPRYPGLLREMLPQDQQYEQRDPAEMPPPQSRLLQYRQQIQPRSPGDLPSPSSSAPN----HNFPAPAQPSYPDTS-----REPPVGFSQAPFPPDHSAGPLPVKYLLQEAHWPHP----GHMLGHGLPFGLQAMAQRQDPGPLQHQQQKQQLQAPQ------------SSLHSLDEYEPRGPGRPLYQRRISSSSPQPYPDSLE-PQD-----------QPVPSYRYPSADLWLGGPGPVPGPAPIHNIPCNGASHIGPHREILVSKAMSEEQMKAECLQPPPPPPPHPASAASLQHHGQFPPLLPSKQTPPDPGGGGNTSPAGHPKPPTMSYASALRAPPKPRPMLPEQSKKNSDPISLLQELSIGSSNSSNGYYTYFK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VUH9-1", "uniprot_id": "Q9VUH9_DROME", "id": "Q9VUH9-1", "name": "", "aln": "MAAEKEMQAHDMVRRRSWARAVALYDQLIAPSPGQGSGGQSAGSRAQKDQQIACLLGRCECLLELGKFEGCLADAYKVLTLLSEQTECLASVSRARRWLVHALFKMHKYGDAEIFLSKWINELSGQQIYSDISKTLERYKSIIQMIMNGQHKAQALKIPHARLEDEMAILDTKLDHWATNNLPLDKYSKLLSNKGLKKREQQQQQQQQQQQQNGNGIGSYASSSSSSSTGSSSTMSSSSTSLHKTNDLLAAMKLTAGKHQPGSGDGSGSDQGDQAAPSTTCSYCTITFQTRNELRQHCQTEAHQKVIMSDEGRDWKWRPPPRGYT-LDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKP--LKAVALLQDAHRNHFALKSIKMCKPTESSMELKSDQ---EWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISKPEDPDSKADP---TKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYCITDGVG-NFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPG-SASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQLDGVELKRGYVLNPLAPEFVPRALQPEAYLREQAALYLNGPQHGHGGHGPPGPPAHFANAAGMLGPGPAAAAHQMNQMAAAMAANQQQLTAHMYSTHMAMMAAAVGGKSGNGPGPGTGGGPGPGPGPPPHYGGGGGGGGHMGMRGPPPPAPHLRGMPPGGPPPTQQPGGAGGGGGPPPPYGQYPAMQHWRPPQQGQNQGPGQQPPQNPNASLWGPPPQTNPWSVLPPSKQPQQPQPPPVSAPGRGPGPLPPPLNANPSLPLRGGSVPPPPPNASTAAHLLRNPSELGYLAKKSLYNHGQALPHHQLYGPGPGPPPP-----------PSQQQPQAPPMGMQRGSSVPNGPMSPMENGPPPPPYLRHNGSGYNPGAPPPPPQQQPQPPPNPFMYAGKQPSPSSMRFGPMTHELLPPNVSIYDMAFNPKDEQYKWYVKLLETVGQDGANKFAEMLRQVMATMQQQQQQHKPPQPPMANNPMLNNPHVQRPQYP--MMYPQGQQQQQQQPPQQSVDASPPLENFNQQIDLVFNSIMNGANDVAQPILRDVLGMVAGTGNAPGPPLSNGLNGVDLQQQQQQQQQQQQSRLFAMMQQQQQQQQQQQAKPPLGPGPLYPNHLGGPGLHQAPPNGGGNLSGVGNTNFMGN---AGNALLNDKPYNNVGMHNNVGLNIGGAG--------VAGHNSNNNNGMLTNGNNSVPLYRRQAHTGNGIGGGNGDYNNMHGMDAG------ANLIEALFQANNSVVDHS--VKSSDHMHGLLYNNFNGLKGGGHELDLFQAMAPSVPHSEAANHHQQSSGSSATTYAAVLSQGPQAVVGGGVGTGPSPGQSQAQAGVAG----SGTGGKVAPAVGRNDLLEK-----DPFAAIRELGQATT----GFYNYFQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * :: * ::: .: :.** :* : * * : :*: * . :. : : : * * : : .* . . .: :.:: ... . *:*: * : . . * . : *::****** * : *:**: * * :*:*****..**.*:** **:.*: * ::::: * : . .* * ::::*:.: :**:*: : : .: .. . :* ::.:*.* : * * * * * :*** **:* **:: ::. ..: : ** ... *. . :: : : * ***:*****:: **.* **:*:::: :*. . :* * : . ::::: : * **: : . : * .. : *:.** ** * :* :*** :::* **: **:.*:*:** :****:*::::::*::..* : :.::** . . ***: *:**. ::* : :**** .***:::. .:* : . :*. **** **:* *: ::*::. :* : : * .* : :*::******:* ** * *:*:: * ::** .: *:***:*::** :. :*:*****:**: ****.*.*:***:*:***:*****:***** *::* * *:::***************:****::* * .* *****:::** **: :*::**: ... .* * :*: :**:*****. * *. *.* *:***::***********:******* ..**:********:** ::* **:**:**:***:***:***:::**:********:*****.:**:**** **:****** *. ********:******:*****:******:*:****.*:*::** :****:: ***:::**:*******:****:*:. :.*************.:********:** : :. . . . . * ******* ********************:****:*****.** ** :*.*: **.*:*:.::: **:.:***: **********:***:: : . :.* : :. *:: *..:. : : :. . .: : : . * . *. *. . * * * * . :. * . *. .: . .* * . .* .* . : . :* : .: .* :. . . . * . . . : : * . .: .: * . : : : .* * : *.* . . . :. :* :: : : :::. .. :* * . * :: . :: : : . : : . : .. .: : : : :: : . . . : : . : . . . . :: :. . :::* * : : . : : : . .* . . . ***:*: :. : . : : : . . .. :.: *. . . : . . . : .* * : . ... . : ** * :.. **. * *: **:: ::**. .:: *:*.**:", "identical_positions": 531, "similar_positions": 519, "identity": "24.59%" }, { "cls_id": "homologset.agr.HGNC:16879", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AYJ4-1", "uniprot_id": "REC8_RAT", "id": "Q6AYJ4-1", "name": "Meiotic recombination protein REC8 homolog", "aln": "--MFYYPNVLQRHTGCFATIWLAATRGSRLVK--------REYLKVNVVKTCEEILNYVLVRVQPPMPGLP--RPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRA--------QLRIRID-MEEADLPSLLLPNCLAMMETLEDAPEPFFGTMSVDPTLPSPFDIPQIRHLLEAATPEKIREETLPEATPEPRKPDRTLAMVQSPEVITLQEAEPIRMLRIE----GEQDLPEISRGDLDLLIAE----EDDAILLEERQRGRLLRQRRASPPLDESKEEPRALEGDGLVSSLSPPAPAQVEGIREPLPDQAFPPEVQKMPGWEPGVLLTEVTPPQELRLPAPPSIEKRPPSPQRPPRRRRRGRQLL---FWDKETQISREKFEEQLQTGAHCCEYP--VVQPPKRKLMSPAELFRTPTLSGWLSPELLALWTHCAQVPPRMLRQRPQLETEETVEEERVADKEERRKTEALSEIEVLREAQEPSGPLMLSSELSLEVAEEEKSRTS-------------------FIPPEERWAWIE-------ERQPEPPALPMLPELPEVPMEMP----PGPELLSSEAVLRAVALELQANREPDFSSLVPPLS----------------SRKLASRVFYLLLVLSAQKILLVDQQKPYGRLLIRLGPKFP-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C5S7-1", "uniprot_id": "REC8_MOUSE", "id": "Q8C5S7-1", "name": "Meiotic recombination protein REC8 homolog", "aln": "--MFYYPNVLQRHTGCFATIWLAATRGSRLVK--------REYLNVNVVKTCEEILNYVLVRVQPPVAGLP--RPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRA--------QLRIRID-MEEADLPSLLLPNCLAMMETLEDAPEPFFGKMSVDPRLPSPFDIPQIRHLLEAATPEKTRKETLPEATPDPRKPDRTLATVQSPEVITLQEAEPIRMLQIE----GEQDLPEISRGDLELLIAE----KDDAILLEERQRGRLLRQRRASLPLDESREEPRALEGAGLVSALSPPAPAQVEGIQEALPGQVFPPEVQKMTGWEPGALLTEVTPPQELRLPAPPSTEKRLPSLQRPLPRRHRRRQLL---FWDKETQISREKFEEQLQTGAHCWEYP--VAQPPKRMLTSPAELFRTPTLSGWLPPELLGLWTHCAQVPQRMLRQRPQLETEETVEEERAADEEERRKTEALSEIEVLREAQEPSGPLMLSSELSLEAAEDEKSRTS-------------------LIPP-EWWAWSE-------EGQPEPPALPMLPELPEVPMEMP----PRPE-LSSEAVLRAVALKLQANKELDFSSLVPPLS----------------PRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKFP-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95072-1", "uniprot_id": "REC8_HUMAN", "id": "O95072-1", "name": "Meiotic recombination protein REC8 homolog", "aln": "--MFYYPNVLQRHTGCFATIWLAATRGSRLVK--------REYLRVNVVKTCEEILNYVLVRVQPPQPGLP--RPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRA--------QLQIRID-MET-ELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERV-EEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIE----GERELPEVSRRELDLLIAE----EEEAILLEIPR--------------------------------LPPPAPAEVEGIGEALG-----PEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVP--PPPRRRRRRRLL---FWDKETQISPEKFQEQLQTRAHCWECP--MVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRR--------ELPEEAAAE-EERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRIS-------------------LIPPEERWAWPE-------VEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLS----------------PRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TGX4-1", "uniprot_id": "A0AB32TGX4_DANRE", "id": "A0AB32TGX4-1", "name": "", "aln": "--MFYYPNVLQRHTGCFSTIWLAATKGIRISR--------RDYLKVNVRRTCEDIVDYVMVQVPPVHPSLP--RPRFSLYLSSQLQYGVIIVYHRQCAFLLEEVQQTIERLLRS--------KRHLNID-MPDNDRLVLNVPDSLFQLEEAEWALEPFFGVMGVD-CVPSPCLSSQQ--FMSASSPLTHTKEITSPKG-----------LVASPETITIKDAELVPVLAAEF---GGAELPEATAHEIDLLMEQ----QDQFHLEDEDKERERVADAEKSGSLDP-------------AMVSIEQLKNSECLMDEGNGRFTEVTLDRVALEMTPPPITMTTTTDASERDVEMESSETLTAEQSVPLKRRGRKRQLI---FADQNTQISQDAMRQQINNPLTETQSLSDVLQSIPASRKASAAVLLSTPCNLLIHPDLQTLWKSCSVSSTLSRPSRKRQAKKESELMEREKERGVERSRESSREVIRESEAALVLSESSAASDVPLDVSKGDRSPSD-------------------LITPNSRWSPIE-------EAP--VSMEVILEEHVDLPLGEA---ELEMSDIITEDLFRLITGFIECRGKVGFHSLLPPEA----------------DRSTVAHLFYQILELLCDLKLSAHQTEAFGVITFTTER----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q12188-1", "uniprot_id": "REC8_YEAST", "id": "Q12188-1", "name": "Meiotic recombination protein REC8", "aln": "MAPLSLNFKDDKKYKGLTTVWLLSALGNSIVKESNNYYSNKSNSTGNISSSTVKKKDIVNISIPKTCDEIQNFENDFSLRYISNLLYGVTICYNKKTEYVLNDLNHLLVQLQKNDVYAFKAKNKSTRINGLNSNNSIIGNKNNNYTWEECVFFDDDPLYDITKVPALEFLNTTLQDNVSFIEEAKSIRRQDYINELSNSNRFELHGDMTNSDAQSNLGSNVRNSFPLDEIPVDVDFNLDLDDIVSHQGTPLGSHSSSQKDGNDFKFNYQGDELVLNFENDNENNSNGGEDTSVENEGPVANLKDYELGLEAQASEEENDLQQKLNTRMQRGHRADVGGQFSKVQFDAKTSYPNEVLKFNHGNYSHLMEKNRIRKLTGQNFLTSNISSLVRSCGEEEFFSTNWLSIFNDFSNIKTSEWDLYPQGFSSVERGRKRAHSLVSTQSSSSTRSHEYGRKSFRNNKNDNYSSDMENDNLLLNLEQINEDLEDGHYIEENSQGNILDFNLNLPPSSFGRSHTRNSTRSSGFNEDIVGALRRRVGPSEQNFAEEDDSSNSCFSDGSQQNLQQDKTNFQDVILDYQTKKFYDYIKERSIVVGRTTRSNPPFKRKMLLVDIIPSRMGEAQTGANFDDVERGVSRQIAASAFLSLLNLATKGMVKLNEYPVADAVTKDLKLRREDEIIVYA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ::: ::*:** :: * : : :. *: : . : * : : : . *** ::* ** * :: :::::::: : :* : : .*: : : : * :*::. * : ::. : . . . . : : . : :* : : * . :: : : * . . . : . .: * *:* * .: . :: . . : . : : . .* . .: . : : . : :: :: * :. :* . .. . :: : : :: : : * . : : .::.. * .: * :* * . : .: . : ", "identical_positions": 33, "similar_positions": 132, "identity": "4.85%" }, { "cls_id": "homologset.agr.HGNC:1688", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P19256-1", "uniprot_id": "LFA3_HUMAN", "id": "P19256-1", "name": "Lymphocyte function-associated antigen 3", "aln": "MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPN--ITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYA---LIPIPLAVITTCIVLYMN--------------------GILKCDRKPDRTNSN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q4S1-1", "uniprot_id": "A0A8M9Q4S1_DANRE", "id": "A0A8M9Q4S1-1", "name": "", "aln": "---------MEFVVRVLLYITCLCFQDFVFCEDYAEMGGRITFTPSIRGKPVEILWKHNGDKVVEYDNRETEEFGSFKDRVVIDFETGQLTIKKLTSQDSGQYQSDITINGKVQSSRHTLTVLDVLPDPRVTCAVNKTSNLQELLCSVDYKTQ---LQYKWSGPNVIDHPGVKLTISEQQKNSDSVYSCTVKNEVSSKTTDFNLQHCVTGAAARLEVIIPVLIVILFIFLIILAIIIYMKKKSKESEQEKMDPENALSQTSLLSQNERPDEENRSDSPGVNEEEKLLNPSGNEGEQCNYVNSPHTFVAVGNASSQPNVTLNRKPLEDQDKVKDGQREKPEEQKTDNAKNNEKNDKVAGKEKEKKKEQQNTADALPAVTQPWETTIHTHSQAEKNYKLPGEKNKEKNKEENGQPNTELPENTHQDLNRQKTSPAQSDQCRQNHEEEKKPEKRNESGETSDQQQNEGEVTATNEDEQTTGANTQEKDHKETKESHTEGSSPQSDEMKKVKEDTKTRGTRDTMENKQNANEQKELDPQKAEDEKKILEENHEENTERSSLQPAVTEENKEDTKTRGTQDTVENNQNANEQKELDPEKDNMAHQTAEDEKTKQEENHVENTDSASEKQTIQNNSDALSSQNEHSADTEKKSVKPDNNKDNNEAKADHNDDDVESPRKEETTGEKSENYDDNNGEGDESSESKQDMKESNNPPDAGIGELLQDDQGKNPDHEQKIDDRSVPKDEQHDIQSDNFQNQEHQNKQNSTERENKPQHEISPEGNETDRKNSELEEEERQRLQK", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: *: : *: * . . : *. : *.:** . . *:***:: ***.* :* * . *.***:** :* :*.*** :***.*..:*: : . .:: :. * **: **.* :***:.: * : : . .*::: : *.*. * : . . : ::: . .**:.* : ..*:.: * *:..:. . :: : : :* .*::**: .:*. :.:**. * . ", "identical_positions": 62, "similar_positions": 93, "identity": "7.81%" }, { "cls_id": "homologset.agr.HGNC:16880", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2BI73-1", "uniprot_id": "A2BI73_MOUSE", "id": "A2BI73-1", "name": "", "aln": "----------------METVSSCEKIPMEVLCEPKNICKAFQDISTYFSDEEWGKLTEWQKSAYVYMKRNYIRMTDLGVTVNQPVFMRGKDQDKQC--LVEGIEVHDSNDECFEGSFG--------VTPRKRMKLTSVTISIHNVEERLASGEYDS---------NLAETGGIQVN--VWSHRLRERKYRVIYSEISDPEEEEDDYY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2AHC7-1", "uniprot_id": "A2AHC7_MOUSE", "id": "A2AHC7-1", "name": "", "aln": "----------------METVISCEKIPMEVLHKPKNICKAFQDISTYFSGEEWGKLTEWQKSAYMYMKRNYTRMT--GVTVNQPVFMSGKEQAKQS--LVKGIEVHDSEDECFEESFG--------VTPRKRMKLTSVTISIHNVEGSLASGENDS---------NLAETDGIQVN--VWSHRLRERKYRVIYSEISDPEEEEDDDY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2BI74-1", "uniprot_id": "A2BI74_MOUSE", "id": "A2BI74-1", "name": "", "aln": "----------------METVSSCEKIPMEVLYEPKNICKAFQDISTYFSDEEWVKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMRGKEQAKQS--LVEGIEIHDSDDECFEGSFG--------VTPIKRMKLTSVTISIHNVEGSHDSGENDS---------NLAETGGIQVN--VWSHRLRERKYRVIYSEISDPEEEEDDDY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B1AY40-1", "uniprot_id": "B1AY40_MOUSE", "id": "B1AY40-1", "name": "", "aln": "----------------METVSFCEKVPMEVLYEPKNICKAFQDISTYFSDEEWGKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMSGKEQDKQS--LVEGIEVHDSEDECFEGSFG--------VTPIKQMKLTPVTISIHNVEGSLASGENNS---------NLAETSGIQVN--VWSHRLRERKYRVIYEEISDPEEEEDDDY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2AHC8-1", "uniprot_id": "A2AHC8_MOUSE", "id": "A2AHC8-1", "name": "", "aln": "------------------------------------MEEAFQDISTYFSDEEWGKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMRGKEQDKQS--LVEGIEDHDSEDECFEGSFG--------VTLRKRMKLTSVTISIHNVEGSLASGENDS---------DVAETGGIQVN--VWSHRLRERKYRVIYEEISDPEEEEDDDY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M0F5-1", "uniprot_id": "F1M0F5_RAT", "id": "F1M0F5-1", "name": "", "aln": "EEDKMVSFQNHSDPIGTKTVSSCAKIPMEVFCEPKNICKAFQDISAYFSDEEWGKLTKWQKSAYVYMKRNYIRMTGLGVTVNQPVFMRCKEQAKQS--VVECIEVHDSEDECSDETYG--------VPPRKRMKLASVTISIHNVKGRLASGKNGS---------NLAGAGGIQVN--AWSHRLRERKTRVIYEEISDPEEDDED--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O60224-1", "uniprot_id": "SSX4_HUMAN", "id": "O60224-1", "name": "Protein SSX4", "aln": "----------------MNGDDAFARRPRDDAQISEKLRKAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQLVVYEEISDPEEDDE---", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :**:**: *** :** *:.. :* .*:*** ** ** *..*. * ** * . . . * .: * : ::* : * : .: :.. .*: . .: :.* : . .*:******* *:*.*******::: ", "identical_positions": 48, "similar_positions": 45, "identity": "23.19%" }, { "cls_id": "homologset.agr.HGNC:16881", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A506-1", "uniprot_id": "A0A8I6A506_RAT", "id": "A0A8I6A506-1", "name": "", "aln": "MAAP--VTRQVSGCAGRVPSPTGSDTERGQPLAAAVAELPVLDASGRRVTFGALFRERRAVVVFVRHFLCYVCKEYVEDLAKIPKSVLQEADVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEE-ISSSG--------------------------------------------NNIHFVHRDRNRLDHKPINSVLQLVGVQPVNFLSRPAVIHV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D1A0-1", "uniprot_id": "PXL2C_MOUSE", "id": "Q9D1A0-1", "name": "Peroxiredoxin-like 2C", "aln": "MAAP--VTRQVSGCAGRVPSPAGSVTERGQPLAAAVAELPVLDASGRRVTFGALFRERRAVVVFVRHFLCYVCKEYVEDLAKIPKSVLREADVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEE-ISSSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFVHRDRNRLDHKPINSVLQLVGVQPVNFMSRPTVIHV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7RTV5-1", "uniprot_id": "PXL2C_HUMAN", "id": "Q7RTV5-1", "name": "Peroxiredoxin-like 2C", "aln": "MAAPAPVTRQVSGAAALVPAPSGPDS--GQPLAAAVAELPVLDARGQRVPFGALFRERRAVVVFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEE-IASSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AUW1-1", "uniprot_id": "A0A8M3AUW1_DANRE", "id": "A0A8M3AUW1-1", "name": "", "aln": "MAAVHPITRQISSSVQDNKQAS------HNICLSELKNCFIFDRHGDKKSFSSLFEHNKAIVIFVRHFLCYTCKEYVEDLGKIPQHVLQDSNVRLVVIGQSSYSHIQGFCSLTGFPHEIYVDPERQIYKRLGLRRGETYMETPSVSPHVKSSMLSGSLKSVWRAMTSPVFDFQGDPQQQGGALIVGPGPDVHFAHFDMNRLDHMPINWLLQLAGLPALDFSDSPKIINI", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** :***:*... .: : : : : ::* * : .*.:**...:*:*:******** ********.***: .*::::* *:******* **: **.***:.*********:******::*** : :.. ::** * * ***** *** :***.*: ::* . * :*::", "identical_positions": 87, "similar_positions": 53, "identity": "37.99%" }, { "cls_id": "homologset.agr.HGNC:16882", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JKA7-1", "uniprot_id": "HCN4_RAT", "id": "Q9JKA7-1", "name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIRLRPLPSPSP------------------------------------------------SVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAE-------------------ERRLIAAEGDASPGEDRTPPGLATEPERPGAAAQPAASPPP----------------------------------------------------QQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEV-----------------------------------------------------------------------RLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED-NTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKT-------ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-GNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAAS-ATPTPTP-----VIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIP-----SALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACS--------------------------SPPAPTPSTST--AATTTG------FGHFHKALGGSLSSSDSPLLTP--------LQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSPGLAAGPPSTPETPPR-PERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPP--RTFP-SAPPRASGSHGSLLLPPASSP--PPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSG---SSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLT-AAPQREPGARSEPVRSKLPSNL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O70507-1", "uniprot_id": "HCN4_MOUSE", "id": "O70507-1", "name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGRQDPSRRSIRLRPLPSPSP------------------------------------------------SVAAGCSESRGAALGATESEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAE-------------------ERRLIAAEGDASPGEDRTPPGLATEPERPATAAQPAASPPP----------------------------------------------------QQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEV-----------------------------------------------------------------------RLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED-NTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKT-------ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-GNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAAS-ATPTPTP-----VIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIP-----SALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACG--------------------------SPPAPTPSTSTAAAASTTG------FGHFHKALGGSLSSSDSPLLTP--------LQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLAAGPSSTPETPPR-PERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPP--RTFP-SAPPRASGSHGSLLLPPASSP--PPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESVAAFSLYPRAGGGSG---SSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTTAAPQREPGARSEPVRSKLPSNL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y3Q4-1", "uniprot_id": "HCN4_HUMAN", "id": "Q9Y3Q4-1", "name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSP------------------------------------------------SAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAE-------------------ERRLIA-EGDASPGEDRTPPGLAAEPERPGASAQPAASPPP---------------------------------------------------PQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEV-----------------------------------------------------------------------RLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED-NTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKT-------ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-GNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAAS-ATPTPTP-----VIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIP-----SALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACG--------------------------SPSAPTPSAGVA-ATTIAG------FGHFHKALGGSLSSSDSPLLTP--------LQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPP--RTFP-SAPPRASGSHGSLLLPPASSP--PPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLT-AGPQREPGARPEPVRSKLPSNL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7TEJ3-1", "uniprot_id": "A0A8N7TEJ3_DANRE", "id": "A0A8N7TEJ3-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHRVHSSMRKRLYSLPHQFGHKGAMNRDGEDSD-------KDTRRKSVKMKHFPSPSS------------------------------------------------TGSSKGVCEAKSGDAETDVGRPFR----TNVNGDCRRFRGSLSSLTSR------------HAAPDADLA-------------------EQRRLIGD--ASPEDD-GPSEQPGPGESPGAQGGRGD-------------------------------------------------------GAQQAPS-------EEQSTFVKLEG----IDQILPDDE------------------------------------------------------------------------RMYQAGFMHRQFGAMLQPGVNKFSLRMFGSEKAVEHEQERVKSAGFWIIHPYSDFRFYWDLIMLLLMVGNLIIIPVGITFFKDEHTPAWIVFNVVSDTFFLVDLVLNFRTGIVKED-STEIILDPQQIKVRYLRSWFAVDFLSSIPVDYIFLIVETRIDSDFYKT-------ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVAKNKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGELNEPLREEIISFNCRKLVATMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTVGKKMYFIQHGVLTVLTK-GSKETKISDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNEVLEEYPMMRRAFETVALDRLDRIGKRNSVLQHKVQRDLNSGVLNYQENEIIQQIVQHDRDMAHCAHLMQTPPPPPHPAPTPSSHTPVIWAPLIQAPLQAAAATTSVAIALTRHPHLPHTLFR-PPVPRLGSL--KDQPGYFKRFPTALSGADTFGGSSSTS-SQFSSCIETPILDTLRAERSSTSTPPPSSSSLPTTITTTVTTTTSSITESSHYHHRPIISHGSKDFSVAQLHSQPQLSQASFSSIAASLPGFFQQGAAGGEAVHLAVPPASTLTPLIAHSVSPILTQLHATHSNPQPTKPIQDLNKAGRTAPQS--PVTESPVHSKSILEQVQSPTSVQSQHPQIGIQPDVLSQLAQEPSALASLAQYGSGNASPCSTP--SAWSPTCQSPTAEKMRMSAHSQPSSISGSQTSLLTPQTLFP--PPPQPRERGGS---LVDLPSQDLSTLSMSLPIPGLAEKSRAVGRGPQPPDLSHHRGSTSGYSPLPSP--------PPLVNPFSSIPG-HVVLSRQTSKLSI--------TQTGSSGGSPAHGSSDRSTPGTPS--LHPKLPSNL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7UQR8-1", "uniprot_id": "A0A8N7UQR8_DANRE", "id": "A0A8N7UQR8-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRLHSSMRKRLYSLPQHIGQKASIMGDAEDSD-------KDTRRKSIRMKPLPTSGE------------------------------------------------IKS------GESAIMETDIGRPVK----TSSNGDCRRFRGSLSSITSR------------HVH-DSDVA-------------------EERRLITDGEVTPSEE-SPPGAAGGGAEPGAQSGGGG-------------------------------------------------------GEEAAGSSQHQGIPDQQAGFIKLEG----IEQILPDDE------------------------------------------------------------------------RYYQAGFMHRQFGAMLQPGVNKFSLRMFGSEKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDEHTPPWIVFNVVSDTFFLMDLVLNFRTGIVKED-NAEIILDPQQIKIKYLRSWFVVDFISSIPVDYIFLIVETRIDSDFYKT-------ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT------------------------------YDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVAKNKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGELNEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK-GNKETKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILQHKVQHDLNSGVLNYQESEIIQQIVQHDRDMAHCANLLQSPSPPAPPSPTP-----VIWAPLIQAPLQAAAATTSVAIALTHHPHLPATLFR-PPVSLLGSR--NEPPSRLKRFQTVAPRTGSTTDSPSTSPSKLHSGVDTPLLASLHTQHSSVTITPSATTNQPVSFRSFSSPSAS------------------PTLSTAQLHPQPRQKQPSTPPLSARLQ------AAGAHPPGILTTASSNTSALSAG-----LSTHSPTHSYPPPKHPQTGSLQFASGGGKSGLTLFHSPPPGSPISIHSQAPESSTSSQ----TQPSFSSYLALERSALASIAQYGSANASPSYTP--LALSPTVQSPVTG--RTFQYSDPSSAAGSHTSLLLPQSSCPGQLPGHHSSGTDS---PLGRFYEDLNILSSSHPSLGVEGAG---------------QSSPGYLSPYLSP--------TLTPKPCSSVSG-HMSSPVQTSPGPR--------GQALSVGTSPALSLPRTSDGDLEP--LRSKLPSNL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z9N7-1", "uniprot_id": "A1Z9N7_DROME", "id": "A1Z9N7-1", "name": "", "aln": "MHVKHTQRRVSGPGAFGTFTNDQRASRDNLCPDNQQQQQQRHSHSHQHLVRQSLVSLSNGQPAASAAPDSVSLLRAGDDQQQHPQQPHLQQQQQQQQHLQQQQQRHRSSSSRLSTSGISKQNSSDSRSGLRILDSSHSPVSCGTQSVSSTGGQSALYDACHEYSRSLSAAAAEGAASLLKSHYSDQQLAQTEPDPEPDPERDRDRDRDRDRDRERERRHLTNLNLNLSSEYDYSGSDKQQLVNETYIFKCIANSPSFLRTNKIKEQSKKLRNLSLKTRTAKKKGQIISKSNAVSDNSLHPGDKYLNLYLVEKKHSLQPQVASTSSSINTTHPQASSAPASSSSTCTKAPQLPALSAVAARQQQLLLNGSLKGKGQSQSQGQSRQTLPGHRASVRSESGSGSSHTIPATGKSPPVPHSLAAKISSSASGSKNCNLLSASSNSCHKLNAHAQGSGAGSGSGSGSGSGPPGHSHYAAASPKSSVSSNGHLNKYCLTDLTRRKAEFNRQLSAPTDYTHHSSSNGSQQEGSSEANEGHEPVGESTITVASAGVSYPHPYSYPYHYAHHASSATAPANLKASLQLHSFGSHHPCPYPARPTSTSCTNSFNRRHIRRHKGKLGDRLLSGDSEESVRCSYCSVLNVNDNDLRISFENTCTDSLVTAFDDEALLICDQGTEMVHFDDVSLYGTPKEEPMPNIPIVSEKVSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVSINELQESYWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNP-----ESNTITAVVNALAAEADDCKDDD---------------------MDLKENLLHGSESSIAEPVQTIREG------LPRPRSGEFRALFEGNTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : :: :** :.. .. . ... :: :: :.: . :. :. . . : ...*:::.. . : .* : :. : . .: . . :: . : : * . .:.*:: *: : :** *::::::***.**: :*: * *::*.*:*** *.******* ****:*.****:**.*:**:*: :. **.** :***:**:*:*:******: :* ::****: * :**::** :*::****:******.: :. : :. .*****:*::*:***:********:**: ****:: : ::**..:**.*** ****: **.***********.** :.**: * : :. * :***:*************** .* .::*:***:**** ******:*:**** ************:** ****:**:::*** * **** :*:*******:**** *****.* ***::*.:***.***::*:*****.***:.::***::******* **:***:*.******.**: :: *. *.::************..**.*****:***.*:*****:** **::**:**:::**** :**::***. .:: :* :: *. :.. * : : .* . * : *:.: :: : .: :. : * : : * ", "identical_positions": 320, "similar_positions": 229, "identity": "17.87%" }, { "cls_id": "homologset.agr.HGNC:16884", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A5D5-1", "uniprot_id": "A0A8I6A5D5_RAT", "id": "A0A8I6A5D5-1", "name": "", "aln": "MTEMPKKTGKKFKFFKFKGLGSLSNLPRSFSLRRSSASPSIRSCPEPDTFEATQDDLVTLPKSPPAYARSSDMYSHMGTMPRPN--IKKAQKQKAVQKAQEVSRE---------------------------------SHLVSRGLPEPPDFEAAKEAEKGTETPLEDT---------------------TPSAVEVDPMRKL---AGLTVDTAEK----------QIPGDAYPERAAAELEA-------------------------AGDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQTLHFKINKVVVEAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG----------LSQGSSKAASPASPSGPKGSHMKRRSVTMTDGLTSDKVT-RGDGCPNSTSLP-------------------HPRDSIRNCALSMDQIPDLHSPLSPISESPSSP-----AYSTVTRVHAASAAPCT-AQPASPVAR--RSSEPQLCPGGAPKPPGESDRGPHASPSHTLCKASPSPSLSSYSDPDSGHYCQLQPPVRCSREPTAGETP-RKARSSAERQKE----LSENG-----------VPEGEWGKTFTAPVAEATSSFNLATFQSQLIP-KENRPLEVGLLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRQDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPFITLLECDSAPAE----------------GPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE--LLEVFSTEFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZS8-1", "uniprot_id": "SH2D3_MOUSE", "id": "Q9QZS8-1", "name": "SH2 domain-containing protein 3C", "aln": "MTEMPKKTGRKFKFFKFKGLGSLSNLPRSFSLRRSSASASIRSCPEPDTFEATQDDMVTLPKSPPAYARSSDMYSHMGTMPRPN--IKKAQKQQAVQKAQEVSRE---------------------------------SHLVSRRLPEPPDLEAAKEAGEGTEALLEDT---------------------APSAVEVDPMREL---EDLTVDTEKE----------QVPGDVSPERTAAELEA-------------------------AGDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINKVVVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG----------LSQGSSKTASPASPSGSKGSHMKRRSITMTDGLTTDKVT-RSDGCPNSTSLP-------------------HPRDSIRNCALSMDQIPDLHSPLSPISESPSSP-----AYSTVTRVHAPSATPSTSAQPASPVAR--RSSEPQLCPGNTPKPPGESDRAPHASPSHTLCKASPSPSLSSYSDPDSGHYCQLQPPVRGSREQAAGETP-RKARGSGERQKE----LLENG-----------VSDGEWGKTFTVPVVEATSSFNLATFQSQLIP-KENRPLEVALLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPFITLLECDSAPAE----------------GPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE--LLEVFSTEFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N5H7-1", "uniprot_id": "SH2D3_HUMAN", "id": "Q8N5H7-1", "name": "SH2 domain-containing protein 3C", "aln": "MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPS--IKKAQNSQAARQAQEAGPK---------------------------------PNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----------------AMEPNPSAVEVDPIRKP---EVPTGDVEEE----------RPPRDVHSERAAGEPEA-------------------------GSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG----------LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVT-RSDGCPTSTSLP-------------------RPRDSIRSCALSMDQIPDLHSPMSPISESPSSP-----AYSTVTRVHAAPAAPSATALPASPVAR--RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKE----LSENG-----------APEGDWGKTFTVPIVEVTSSFNPATFQSLLIP-RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPE----------------GPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE--LLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B1T6-1", "uniprot_id": "A0A8M2B1T6_DANRE", "id": "A0A8M2B1T6-1", "name": "", "aln": "---MIKRK------LSFKWFGSLTNLRRKSDAQKDDESVK----------EMSTDDMGMHPRSP-SYATSSEMYTHMGTMPRHSKKDKNSKKSKSKDKANLTRSQSLRPDHVVESPLLSMLSGKGMEVLENPIIEDKTAHIQNRDLPPPPCVDGHSTRLEDENKKLEVNFKHVDASNACLGASIELCVSQESTVQPVLPKKRLKEGDKLMKDTEELKQDSNLIQLPQKTGNRMEKKIAVEEDANIVWNYKLDGQEEKELNSELDITENQGEYVEFSKEKYLLESPPEKLRKELEEELKLSSSDMRSHGWYHGHIPREASETLVLRSGDFLVRDSLSTVGDYVLTCRWQQEVIHCRISKVLVKSGQ--TKIQYMLENESFDSVPTLVRHHAGTGRAVCPRTGAQLLCPVNRTLPLRYLEATFA----------LAGG--RPGSAYSPSAQRGAHIKRRSVTMTDGLTTEKIIPHSVAQPTQPDEPQTVEPEVKPAEGNSCPSTVHHKDAMRNCAMSMDQIQEYRCPLSPVGETPQSP-----AYSAISRHRHGSGGRVLAVIPPSPVMR--RSSDPHLSPSSSNNNIPCSETGPSTYS-------TPAHGYQSESLEQGGSYCELRP----------GQAPIPPCKSYVERLKVEEGQSLGSG-----------APDGVEG--FMLPLVETSSSFKPGKYQSTLLP-PENKPLEMSVLKRVKELLAEVDPKTAAKHITKADCTVARILGVTKEMQRMMGVSSGLEQLTLPHGHQLRLDLLERFYTMSIMMAVDLLGCTGSTEERAALLHKTIQLAAELKSNMGNMYGFAAVMRALELPQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKAMNDGKETCVLSSTCFPHVVPVLSLLERSVAAGE----------------ALESWESVESGVDVVMSHLEAARTIAHHGGLYRTNAESKLQDFQERKE--VLEIFCTEFQMRLLWGSRGSEGSQTERYEKFDKVLTALSHKLEPPVRHSEL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VMJ4-1", "uniprot_id": "Q9VMJ4_DROME", "id": "Q9VMJ4-1", "name": "Breast cancer anti-estrogen resistance protein 3 homolog", "aln": "-MGNTQARQLENRQVPNRRSSILWNFRYSNTVRRREDLAVMVHNSRMSISEWLDLLELQQYEGNLQEFSTVDDVVDITDKELKQFGVRGAHRQRMVNSLLGVRAK-------------------------------RRQSMNLEAMSSAPRAVPRRKNSCPLVYLGENPQD---------------MAGSGDSGPGVITTKSGKVLKQLTFDETSTIYEELRPRSKCNSPHWAIEDSRMEGYG----------------------SSNATTPLATAQPSPSEQQEAIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLESKFTTHSLPRPNTSAAHALRQQAVARISSLARNCSLDSPSDSRPPSPPPKPRKEPMAAVLAYQASGSDSGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMAIEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQ-TDLDRAQLLSKWIQIAVETKTALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEASN-PQAPNTTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADKFCMMAEQ---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : . * *: . :: . * .. : : .: . : ::..: . . : : :. .* * : * . : * . . . : * . : :: . :. . *:* ** **.*.: ::***.**** :**: :* :* *.****:**. : .:***:** : .:* :.*::::. :::* :*:::** ** *: .:.*: :.:. :** : * *** ** : . * *. .... *: :: .: ::: . . .. * : :. *: :.:* . : : * .. :.:::* . . .. .: * *: * . : . . .*. .. . .. :: : : .. . : .:.:*.*. .: : *:* :*:**: *. .* :* *...: *.*:*: * :* :* ..: : *:* ******: :* *::** :.:*:** :* * : :** ** * **:*.* : :**::.*.*:* .* : **.:*:*:* ***::*:.*: :* **:* *. :*:..: ..* .***: *:: . : : *: : : **:*:* . :: **:.**: *:. . * : : : * ***::::**** *: .. *::*::**** ::.*: . ", "identical_positions": 165, "similar_positions": 263, "identity": "16.18%" }, { "cls_id": "homologset.agr.HGNC:16885", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VMJ4-1", "uniprot_id": "Q9VMJ4_DROME", "id": "Q9VMJ4-1", "name": "Breast cancer anti-estrogen resistance protein 3 homolog", "aln": "MGNTQARQLENRQVPNRRSSILWNFRYSNTVRRREDLAVMVHNSRMSISEWLDLLELQQYEGNLQEFSTVDDVVDITDKELKQFGVRGAHRQRMVNSLLGVRAKRRQSMNLEAMSSAPRAVPRRKNSCPLVYLGENPQDMAGSGDSGPGVITTKSGKVLKQLTFDETSTIYEELRPRSKCNSPHWAIEDSRMEGYGSSNATTPLATAQPSPSEQQEAIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLESKFTTHSLPRPNTSAAHALRQQAVARISSLARNCSLDSPSDSRPPSPPPKPRKEPMAAVLAYQASGSDSGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMAIEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRIDIALF--LEEPSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDLDR-AQLLSKWIQIAVETKT-ALGNLFGFCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEASNPQAPN-TTVPHVLLYALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKIILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADKFCMMAEQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9BRG2-1", "uniprot_id": "SH23A_HUMAN", "id": "Q9BRG2-1", "name": "SH2 domain-containing protein 3A", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRS-------FSEDTLMDGPARIEPLRARKWSN-----------------SQPADLAHMGRSRED----PAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPP-------------------------RTPSFELPDASERPPTYCELVPRVPSVQG----TSPSQSCPEPEAP--------------------------------------------------------------WWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGP--QNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEG------------------EEVAGPLDESCERL-----LRTLHGARHMVRDAPKFRKVAAQRLRGFRP--NPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR--", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::. *..:* .:.**** *.**:** ::*::****** ..*: .* *:*** :.:.*** : ::.*:*.. . :*:*:: * ::* *: *: . :*:*.*:**::. * . ** . :: * :.**.: ** .* :*: *. * . *. . .. * . ** ...: :** *:: : .: *** : : * *: *::* . : *.*:.*: ***:* * . .* ::. *** . * .: ** * :*:**: :.*:*:: ::** * * *: :* * . ::.. .***********: :* :::** * : * *:::* *. *:. * * :::*: :. * *:* *:.*:* .* * *:.:*:::*: **:.:*::*::** :*:* : ::*.:.* *. .::*** . *:: . .* :...: : :: *..:* :::: :** * *.. * : * :*: * * ::**** ** * :*.:*:::** :::::: ", "identical_positions": 166, "similar_positions": 203, "identity": "17.49%" }, { "cls_id": "homologset.agr.HGNC:16887", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q923S2-1", "uniprot_id": "PDZ1I_RAT", "id": "Q923S2-1", "name": "PDZK1-interacting protein 1", "aln": "-MLALSLLALGLLAEVAPASCQQGLGNLQP-WMQGLIAVAVFLVLVAIAFAVNHFWCQEEQEPGSTMMITGNKADGVLVGMDGRYSSMASGFRSSEHKNAFENVLEEEGRVRSTPM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQH0-1", "uniprot_id": "PDZ1I_MOUSE", "id": "Q9CQH0-1", "name": "PDZK1-interacting protein 1", "aln": "-MLAFSLLVLGLLAEVAPASCQQGLGNLQP-WMQGLIAVAVFLVLVAIVFAVNHFWCQEEPEPGSTVMIIGNKADGVLVGMDGRYSSMASGFRSSEHKNAYENVLEEEGRVRSTPM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13113-1", "uniprot_id": "PDZ1I_HUMAN", "id": "Q13113-1", "name": "PDZK1-interacting protein 1", "aln": "-MSALSLLILGLLTAVPPASCQQGLGNLQP-WMQGLIAVAVFLVLVAIAFAVNHFWCQEEPEPAHMILTVGNKADGVLVGTDGRYSSMAASFRSSEHENAYENVPEEEGKVRSTPM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q90X36-1", "uniprot_id": "Q90X36_DANRE", "id": "Q90X36-1", "name": "", "aln": "MGKPVSVFYWFLLTLGLVAAQAETAGRALPNWLTGIIAVAVFLFLVFISFLVNKAWCNNPSQPEAVIPNAYAMTNGSSI-----HETSLDAVRSGDGPNMYENVIVHQTEEKVTAM", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..*:: **: *: : *. * *: *:*******.** * * **: **:: :* : ::* : :.: ..**.: * :*** .: . : *.*", "identical_positions": 33, "similar_positions": 32, "identity": "28.45%" }, { "cls_id": "homologset.agr.HGNC:16888", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q58NB6-1", "uniprot_id": "DHRS9_MOUSE", "id": "Q58NB6-1", "name": "Dehydrogenase/reductase SDR family member 9", "aln": "MLFWLLALLFLCAFLWNYKGQLKIADIADKYVFITGCDTGFGNLAARTFDKKGFRVIAACLTESGSAALKAKTSERLHTVLLDVTDPENVKKTAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTELADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSSVNLDLSLVVGCMDHALTSLFPKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPKAV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8VD48-1", "uniprot_id": "DHRS9_RAT", "id": "Q8VD48-1", "name": "Dehydrogenase/reductase SDR family member 9", "aln": "MLLWVLALLFLCAFLWNYKGQLKIADIADKYIFITGCDSGFGNLAARTFDRKGFRVIAACLTESGSEALKAKTSERLHTVLLDVTNPENVKETAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTGLADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSSTSSVNLDLSLVVECMDHALTSLFPKTRYTAGKDAKTFWIPLSHMPAALQDFLLLKEKVELANPQAV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BPW9-1", "uniprot_id": "DHRS9_HUMAN", "id": "Q9BPW9-1", "name": "Dehydrogenase/reductase SDR family member 9", "aln": "MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*:*.**:**.***. **:*** **:***:******:***********:***:*********** ****:*****:*******:*****.******.:*************** **********::**************.************:********:*****: *************************************** ****:*. *******::******************.:**...* **:*** ** *************:* ****** **********.********:*.*****:**", "identical_positions": 268, "similar_positions": 39, "identity": "84.01%" }, { "cls_id": "homologset.agr.HGNC:16889", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O00487-1", "uniprot_id": "PSDE_HUMAN", "id": "O00487-1", "name": "Ubiquitin C-terminal hydrolase PSMD14", "aln": "MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "O35593-1", "uniprot_id": "PSDE_MOUSE", "id": "O35593-1", "name": "Ubiquitin C-terminal hydrolase PSMD14", "aln": "MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JZJ1-1", "uniprot_id": "A0A0G2JZJ1_RAT", "id": "A0A0G2JZJ1-1", "name": "Ubiquitin C-terminal hydrolase PSMD14", "aln": "MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9V3H2-1", "uniprot_id": "PSDE_DROME", "id": "Q9V3H2-1", "name": "26S proteasome non-ATPase regulatory subunit 14", "aln": "MDRLLRLGGAMP--QAAPPTDAPVVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVQVIDVFAMPQTGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINPNMLVLGQEPRQTTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSWKDGLTLSDYNEHCSINEDTVAEMLDLAKNYNKSLEDEEKMTPEQLAIKNVGKQDPKRHLEEKVDKVMQNNIVQCLGAMLDTIVFK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P43588-1", "uniprot_id": "RPN11_YEAST", "id": "P43588-1", "name": "Ubiquitin C-terminal hydrolase RPN11", "aln": "MERLQRL--MMN--SKVGSADTGRDDTKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLEPRQTTSNTGLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLHKEQWQSGLKMYDYEEKEESNLAATKSMVKIAEQYSKRIEEEKELTEEELKTRYVGRQDPKKHLSETADETLENNIVSVLTAGVNSVAIK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:** ** * .:*: ** * *****:*******************************.*:*******:********** ******:******** :*****************.**:***:*** *..*************************:.. :: . ******** * *:*..:*************:.*:*:*. * ***:****:.* .**.: **.*: . * .. .*:.:*::*.* :*:*.::* *:* : **:****:**.* .* : .***. * * ::::.:*", "identical_positions": 196, "similar_positions": 68, "identity": "63.23%" }, { "cls_id": "homologset.agr.HGNC:1689", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P58019-1", "uniprot_id": "CD59B_MOUSE", "id": "P58019-1", "name": "CD59B glycoprotein", "aln": "MRAQRG--LILLLLLLAVFCS--------TAVSLKCYNCLDP-VSSCKINTTCSPNLDSCLYAVA-GRQVYQQCWKLSDCNSNYIMSRLD-VAGIQSKCCQWDLCNKNLDGLEEPNNAETSSLRKTALLGTS-VLVAILKFCF----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O55186-1", "uniprot_id": "CD59A_MOUSE", "id": "O55186-1", "name": "CD59A glycoprotein", "aln": "MRAQRG--LILLLLLLAVFCS--------TAVSLTCYHCFQPVVSSCNMNSTCSPDQDSCLYAVA-GMQVYQRCWKQSDCHGEIIMDQLE-ETKLKFRCCQFNLCNK-----------SDGSLGKTPLLGTS-VLVAILNLCFLSHL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P27274-1", "uniprot_id": "CD59_RAT", "id": "P27274-1", "name": "CD59 glycoprotein", "aln": "MRARRG--FILLLLL-AVLCS--------TGVSLRCYNCLDP-VSSCKTNSTCSPNLDACLVAVS-GKQVYQQCWRFSDCNAKFILSRLE-IANVQYRCCQADLCNKSFE--DKPNNGAISLLGKTALLVTS-VLAAILKPCF----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P13987-1", "uniprot_id": "CD59_HUMAN", "id": "P13987-1", "name": "CD59 glycoprotein", "aln": "MGIQGGSVLFGLLLVLAVFCH--------SGHSLQCYNCPNP-TADCKTAVNCSSDFDACLITKA-GLQVYNKCWKFEHCNFNDVTTRLR-ENELTYYCCKKDLCNFN----EQLENGGTSLSEKTVLLLVTPFLAAAWSLHP----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F2M5-1", "uniprot_id": "E7F2M5_DANRE", "id": "E7F2M5-1", "name": "MAC-inhibitory protein", "aln": "MKASVGVCVVFVLALLGLG------------SAIKCYNCKDYTG-ACSKIKDCYYD-DACLSVYERGGDTYRQCIKYSECDYSTVGVKFPKLSSFKFSCCTSDLCNS-----------APLSVSSRSVVAILLPLALFWWGVF----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3ANX3-1", "uniprot_id": "A0A8M3ANX3_DANRE", "id": "A0A8M3ANX3-1", "name": "MAC-inhibitory protein", "aln": "MKLSLGLFLLVCCVTLSLGNKHYGMRFSSAGSSLRCYKCEDYAGGRCSVQQPCSYE-DACLHLHEKGGKTIRRCIRYTDCDNSRLSQQFPSISEYTYRCCNTDLCNG-----------GPLTTAGSLFLSLLAVFTGLFHCMIC---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * .. .: :: **:* : *. * : *:** * .. .:* : .*. . : :: ** :*** .: :. ", "identical_positions": 18, "similar_positions": 27, "identity": "12.24%" }, { "cls_id": "homologset.agr.HGNC:16890", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R4W4-1", "uniprot_id": "M0R4W4_RAT", "id": "M0R4W4-1", "name": "protein-serine/threonine phosphatase", "aln": "MDGPAIITQVTNPKEDEARSPVAGEKASQRNISLKKQRGRSILSSFFCCFR--------------------------------------DYNVEPPPP--SSPSVLPPLVEEN-----------------------------------GGLQKGDQRQVIP------------------------------------------VPSPP----------------------------------AKYLLPEVTVLDHGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKR---------------------------PHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLS--REDDVYRMLHR----LCSR------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P58465-1", "uniprot_id": "CTDSL_MOUSE", "id": "P58465-1", "name": "CTD small phosphatase-like protein", "aln": "MDGPAIITQVTNPKEDEARSPVAGEKASQRNISLKKQRGRSILSSFFCCFR--------------------------------------DYNVEAPPA--NSPSVLPPLVEEN-----------------------------------GGLQKGDQRQVIP------------------------------------------VPSPP----------------------------------AKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKR---------------------------PHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLS--REDDVYSMLHR----LCSR------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15194-1", "uniprot_id": "CTDSL_HUMAN", "id": "O15194-1", "name": "CTD small phosphatase-like protein", "aln": "MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFR--------------------------------------DYNVEAPPP--SSPSVLPPLVEEN-----------------------------------GGLQKGDQRQVIP------------------------------------------IPSPP----------------------------------AKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKR---------------------------PHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLS--REDDVYSMLHR----LCNR------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BAS3-1", "uniprot_id": "A0A8M2BAS3_DANRE", "id": "A0A8M2BAS3-1", "name": "protein-serine/threonine phosphatase", "aln": "MDNTSIITQVTNPKEEE-ILSTNAEKVSLSNSSLKKKRTRSIFSSLFCCLR--------------------------------------SYDADTPATPNNNSSPLPPPVEEN-----------------------------------GGPPKCDQVEVIP------------------------------------------VPSPP----------------------------------EKYLLPEVNINDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTVHQVYVLKR---------------------------PHVDEFLQKMGELFECVLFTASLAKYADPVADLLDQWGVFRARLFRESCVFHRGNYVKDLSRLGRELRNVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLLPFFEGLS--KEEDVYGVLQN----LRGR------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TD10-1", "uniprot_id": "A0AB32TD10_DANRE", "id": "A0AB32TD10-1", "name": "", "aln": "MDNTSIITQVANPKEEE-ILSSCQEKVSQSNSSLKKHRNRSIFSPFFCCFR--------------------------------------DYNAEPPAT-NNKTCSLPPPAEDN-----------------------------------SSSPKCDQVQVIP------------------------------------------IPSPP----------------------------------AKYILPEVSINDYGKNCVVIDLDETLVHSSFKPISNADFIVPVEIDGTVHQVYVLKRPHVDELLFVFLSVIVCLVCLKVYVLKRPHVDEFLQKMGEMFECVLFTASLAKYADPVADLLDQWGVFRARLFRESCVFHRGNYVKDLSRLGRELNKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLLPLFEGLS--RETDVYSVLQS----LRDR------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9PFN0-1", "uniprot_id": "HZG_DROME", "id": "M9PFN0-1", "name": "Phosphatase Herzog", "aln": "MDATSIITQVSRDDEQLNVYPSYPNDKDAWLGFSGSVWLPDCPADHAQLTH--------------------------------------DVDRLKPQK-RGLFHSLLCCWRRN-----------------------------------RTKTNQNGTQIDG------------------------------------------STTPPP-----------------------------LPDQQRYLLPQVRLTDMHRKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKR---------------------------PHVDEFLQKMGELYECVLFTASLAKYADPVADLLDKWNVFRARLFRESCVYYRGNYIKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLS--KVDSVYSVLCNSNQPLNNQTNQQQHPQELQQAPNQLHQQLQQQQQQQTISATTVITQATTLSAPTMLNQQQTSPPSPQSELLQKT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07800-1", "uniprot_id": "PSR1_YEAST", "id": "Q07800-1", "name": "Phosphatase PSR1", "aln": "MGFISSILCCSSETTQSNSNSAYRQQQSSSLNKNRSVKHSNTKSRTRGVHQTNSPPSKTNSAATFSSTERSTGKSGISTNDNEKKKPSSPTAAVTATTTNNMTKVEKRISKDDLYEEKYEVDEDEEIDDEDNRRSRGIVQEKGDAVKDTSRQKKQQQQQQQQSQPQPQPQSQSQSQSQSQSQQRGPTVQVSSDHLIQDMNLSRVSSSSQASETSNDADDEDDEDEEYIDLTLLQQGQYHAPGYNTLLPPQDESTKGKKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKR---------------------------PGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDVGKILDVTI------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q07949-1", "uniprot_id": "PSR2_YEAST", "id": "Q07949-1", "name": "Probable phosphatase PSR2", "aln": "MGFIANILCCSSDTSKTHRQ---RQPPETNHNRNRNRKHSSNKAQTQGRKQKATP---NGDKMQYSTPEILLSSSDSGSN------AGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMT-----EVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNS---SINDEAPPQQG-LYQVGQE----DMNPQYVASSP-----DNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKR---------------------------PGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLSSGNVLDVGSVLDVTI------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. : * : . : . . . : : . : : . . .:.. :** ::*:::************ : .***::.****. :*:***:** * *:***:::.:::* *:****:::*.:*: * ** .:: *****:* :.***:*:*.::** * . :*:***********::*:*:.***.* * ** :::*::* ** .* :* ", "identical_positions": 87, "similar_positions": 76, "identity": "16.54%" }, { "cls_id": "homologset.agr.HGNC:16891", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A5Q0-1", "uniprot_id": "A0A8I6A5Q0_RAT", "id": "A0A8I6A5Q0-1", "name": "Tribbles homolog 1", "aln": "--MRVGPVRFALSGASQPRGPALLFPAARGTPAKRLLDTDDAAAVAAKCP-------------------------RLSECSNPPDYL-SPPGSPCSPQPPPSAQGTGGSCVSAPGPSRIADYLLLPLAEREHVSR------ALCIHTGRELRCKVF------------PIKHYQDKIRPYTQLPSHRNITGIVEVILGESKAYVFFEKD-------------FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHMIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPEILLHPWFEY-VLEPGYVDSEVGTSDQIVPEYQDDNDVSSFFC----------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4K4-1", "uniprot_id": "TRIB1_MOUSE", "id": "Q8K4K4-1", "name": "Tribbles homolog 1", "aln": "--MRVGPVRFALSGASQPRGPGLLFPAARGTPAKRLLDTDDAGAVAAKCP-------------------------RLSECSSPPDYL-SPPGSPCSPQPPPSTQGTGGSCVSSPGPSRIADYLLLPLAEREHVSR------ALCIHTGRELRCKEF------------PIKHYQDKIRPYIQLPSHSNITGIVEVLLGESKAYVFFEKD-------------FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPQILLHPWFEY-VLEPGYVDSEIGTSDQIVPEYQEDSDISSFFC----------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96RU8-1", "uniprot_id": "TRIB1_HUMAN", "id": "Q96RU8-1", "name": "Tribbles homolog 1", "aln": "--MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCP-------------------------RLSECSSPPDYL-SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSR------ALCIHTGRELRCKVF------------PIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKD-------------FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFES-VLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC----------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R8QE16-1", "uniprot_id": "A0A2R8QE16_DANRE", "id": "A0A2R8QE16-1", "name": "", "aln": "--MSVQWIHNPVT-----------LPGRHG---HKRFDTDEP---VSRCP-------------------------RLSESSADAGLLGSSPGSPVSGAPLSVTS-------AHQGPARIGQFLLVPLTDRPGVQS------ALDMDTGEELLCKVF------------DMGQYQEKIRAYSMLSNHKNIAQIKDIVLGESKAYVFQEKD-------------FGDMHTFVKSSKRLSEDLASKLFYQVVSAVNHCHQVGIVLGDLKLRKFVFTDEKRTHLKLEGLEYCHVLCGEDDSMFDTHGCPAYVSPEILNGGGCYSGKQADVWSLGVMLYTMLVGRYPFHDADPATLFSKIRRGTYCLPDGLSLTARCLLRSLLRKDPGERLTAAEVLIHPWFNSNIQDSRNPEQEVNLREQTVPQIEMEQDEDLFS-----------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V3Z1-1", "uniprot_id": "TRIB_DROME", "id": "Q9V3Z1-1", "name": "Tribbles", "aln": "MDNSSGQNSRTASSASTSKIVNYSSPVSPGVAAATSSSSSSSSSGMSSSQEDTVLGLFTPKKEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQPVKLIQQRYLISAQPSHISAAVAAKTPASYRHLVDLTASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQMAQNANGLSTEPEPDTDVDMG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : * * .:... : . :* . . * .: : : . . * : * *. .: : **.:: *: . : ::::::* . : * : ::*:: : ::*:::: *** * * :* *: .:* **: .*:* ****::* * * **:*: *.** :: ****:: *. *** *.:**:* *.** **:*****:***:***:***:: . *:: **:* :* :* ..* *: ****:: **:**..::: **:. :: :: : : ", "identical_positions": 88, "similar_positions": 101, "identity": "18.18%" }, { "cls_id": "homologset.agr.HGNC:16892", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3U0X8-1", "uniprot_id": "TACT_MOUSE", "id": "Q3U0X8-1", "name": "T-cell surface protein tactile", "aln": "MGRKWTYCVVYTIIQIQFFRGVWEELFNVGDD-VYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEP-YTQDEHN--YTIEIETNRTLEIPCFQNTSSEIPPRFTFSWLVEK----------------DGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQIQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNVFPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHS-GPSQSNNMTAWCMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYLATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWPFPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHD-TIISTTTEFPNVLTTANGTTKIDHGPITSIIVNQPSDGMSWPVLVAALLFFCTLLFGLGVRKWYRYQNEIMERPPPFKPPPPPIKYTYIQEPIGCDLCCHEMEVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5BK49-1", "uniprot_id": "TACT_RAT", "id": "Q5BK49-1", "name": "T-cell surface protein tactile", "aln": "MGRKWTYCVVYAIIQIQFFRGAWEELFNAGDNNVYALPGSDVNLTCQTMEKDLMVQMQWSKVTDEIDMIVVYHPQYGFHYMQGVACESRVAAVETLKDATKWTLNLRNISSSLSGKYECSFTMYPTGTKTIVYNLIVEP-YTQDEHN--RTIEIETNRTLEIPCFQNTSSEISPRFTFSWLVEK----------------DGVEDVLFTYDYHVSNSTAFKGRVGLGADYGLRLSPVQIQDDGRTFSCFLRISPLKVWKTSTTVKVFAKPEILMTVENTTMDVLGERVFTCLLKNVFPKASITWLIDGRLFQGNEEGIYITNEEKNSSSGFWELKSVLTRMHN-RTSQSNNMTVWCMALSPGPGNKMWNTSSQPITFSLDSGTAPTKRLPNVTGSTLGAQTFPDAEVSPTRYLATSSMTIVDENVLTPDPTPQTSNSSMTTKDVNYSQPSSGTDAKNSSRAASSSDGGSRPFPSTSPPKWLSLPHTSTGPQEPDSAVSWIPTDAYTSGSSDASLTSHD-VIIRTTKEFPDVLTTANGTTKIKHGHVTGITVNKPRDGMSWPVAVATLLFFCILLFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYMCIQEPTGRGMPCHEMEVL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P40200-1", "uniprot_id": "TACT_HUMAN", "id": "P40200-1", "name": "T-cell surface protein tactile", "aln": "MEKKWKYCAVYYIIQIHFVKGVWEKTVNTEEN-VYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVENSSTDSWVLLSKGIKEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKS--------------------------------------VSRIPSETYSSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVIVAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYTCIQEPNESDLPYHEMETL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :**.**.** ****:*.:*.**: .*. :: *** ***:****** .::*********:: *:*.:******:: .*** *: .** :. ::*** ***:*.::.*:*** :.:** * :* :***:::. * ** * ***** *:*********:**:*...**::* **: :*.::.*:: .: :.*** :*.*: ** ** *:****** ****.***.: :.* * : ************ : ***.: *** ** ************.***:*** :::.::*********:: ..** ********:*. .:**:*:* ******* * **:** **: **. :.* :.*. .** ***.:*. . : ***: * **.*:*:** . * *:.***.*******:. ** .*****:*:* ** **::.::*.. .*. : ** .: *: *.:* *****:** .* :*.* **:* ******* **:*** * :********* :**:****************** **** .: ****.*", "identical_positions": 315, "similar_positions": 150, "identity": "50.48%" }, { "cls_id": "homologset.agr.HGNC:16893", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A147-1", "uniprot_id": "A0A8I6A147_RAT", "id": "A0A8I6A147-1", "name": "Perilipin", "aln": "--------MQLLLRPCLAMGQKLLLKKFRLLWRILPCSVVGRVANLPLISSTCGMVSAAYTSTKESYPHVRTVCDVAEKGVKTLTTAAVSRAQPILSKLEPQIVTANKYAHQGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAREMVSSSVSGAKDTVATRVTGAVDVTCGAVKSSVDMTKSAMTSGVQSIMGSRVGQMVISGVDRVLVKSEAWADNRLPLTDTELALIATSPEGADMASLQQQRQERSYFVRLGSLSERLRNQAYEHSLGKLCNVRQSAQDALQQLAHVLSLMESVKQ---GVDQRLEEGQEKLHQMWLTWNQKTPQ----------DAEKDPSKPEQVEAQALSVFRDIAQQLQSTCVALGASIQGLPSHVREQAQQARSQVDDLQATFSGIHSFQDLTASVLAQTREHIARARDALEHTVEYVAQNTPAMWLVGPFAPGITEKAPEEK-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DBG5-1", "uniprot_id": "PLIN3_MOUSE", "id": "Q9DBG5-1", "name": "Perilipin-3", "aln": "--------MSSNGTDAPAEAQAAMEEP------VVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAHRGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAQEMVSSSVSSAKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGVQSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQQRQEQNYFVRLGSLSERLRNHAYEHSLGKLQNARQKAQETLQQLTSVLGLMESVKQ---GVDQRLGEGQEKLHQMWLSWNQKTPQ----------DAEKDPAKPEQVEARALSMFRDITQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTPAMWLVGPFAPGITEKTPEGK-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60664-1", "uniprot_id": "PLIN3_HUMAN", "id": "O60664-1", "name": "Perilipin-3", "aln": "--------MSADGAEADGSTQVTVEEP------VQQPSVVDRVASMPLISSTCDMVSAAYASTKESYPHIKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDKLEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSS----AKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQVLSLMETVKQ---GVDQKLVEGQEKLHQMWLSWNQKQLQ----------GPEKEPPKPEQVESRALTMFRDIAQQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRERVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QGJ3-1", "uniprot_id": "F1QGJ3_DANRE", "id": "F1QGJ3-1", "name": "Perilipin", "aln": "--------MADNVKTAEKDKEDSQEQQ----------SVISRVGNLPLVSSACGAVYNAYSSTKDSVPLLKGVMEVAESGVRTLGAAASTGSKPILDRLEPQIAAVNEYAIKGLEKVEGNLPILQQPADKLVSDTVGMVYQSVTG----------------------AKDAVVGAVMEGVEKTRMAVTGGINTVMGSRVGQMVSNGVDKALTHSEDWVEQNLPISEKELATLAEPRPGEEEGFIVSTR--SSYFVRLGKLSAKVRERALEQSLLRARKARDTTHASVTQMTSTMDLLESARVTLTSANQQLAGAPEQLLQRWKEWKEGQPKELQEKVTAETEADGAKDKEQEMESKALLMVRGLSDQLKTACSGVVSSVQGLPGTVQEQLLNARRTAGELQASLSGT---KTLTPVLLLQTRQQIGQVRQSLDGVVEYLLNNTPLNWLVGPFAPQITEKGE----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VXY7-1", "uniprot_id": "LSD2_DROME", "id": "Q9VXY7-1", "name": "Lipid storage droplets surface-binding protein 2", "aln": "MASAEQKHATGNGTTGNGTAMNDVDQPKDAKDLLPHLESLERIIKLPVVNAAWDKSQDVYGKVKG----KNRVFEWALTAAEDCVTRAVTTAAPFVTKLDRPIAYVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQP-------------------HLERVVKFKAAGQQKAASLKDLAWQKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVEEDNDDK---------------------------------QNAVVQNGKSSENDMPVPASEDPVLHTVQTVGR--------LSNKISRRVYRNVSRQIKQVQ----------------KGNINDYLSSLIAALKLHQYINFINSSMGTNVEQSGGSSSDACSPFGTTTSTTTTTTTSSTSNNKPVVALPHVAKSKRAPAVSSQ---------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : *: :*::.:: . .* ..* . * : * .... : * : : *:: :*: *. ..: :*::::: . **:::..::: :: * . * .* . . : : ::.:: *.:. .*** . :* : :* : :: :::: : : . .: :::. * .: : : : :* : : :: .: :.:: : . :: :. : : ::.: . . .: ", "identical_positions": 24, "similar_positions": 115, "identity": "5.16%" }, { "cls_id": "homologset.agr.HGNC:16894", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZD83-1", "uniprot_id": "D3ZD83_RAT", "id": "D3ZD83-1", "name": "Solute carrier family 75 member 1", "aln": "-----MGWAGDAGCTPRPPIRP-------------------RLASERRVIIVIFLG-------------------------------LLLDLLAFTLLLPLLPGLLERHGREQDP-LYGSWQRGVDWFATAIGMPAEKRYNSVL-----FGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMMSLTGLAISYAVWATSRSFTAFLASRVIGGISKG-NVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVE----------MVPWISLLFAVSDMLFIFCFLPETLPQEKRASSVTLGFHTAANLLSPLALLRFAAVAHSQD-------PPTEDGLRNLRRLGLVYFLYLFLFSGLEYTLS---------FLTHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRIRP----------------------------------------------GKEAAAVKRAMLLLVPAFLLIGWGHSLPMLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRAVGPIMAASEAAASSTDSQGGVAEPSCCEAGAWARTTPLLAHSFLRAQGGLPHSSSQDGNPAGSLGSHVLFFFFFFWFFFSELGTEPRALRFLGKRSTTELNPQPQPRPFLTPKPFRLLIFLISHSSE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D2V8-1", "uniprot_id": "S75A1_MOUSE", "id": "Q9D2V8-1", "name": "Solute carrier family 75 member 1", "aln": "-----MGWAGDAGCTPRPPIRP-------------------RPASERRVIIVLFLG-------------------------------LLLDLLAFTLLLPLLPGLLERHGREQDP-LYGSWQRGVDWFASAIGMPAEKRYNSVL-----FGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKG-NVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVE----------MVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSPLALLRFAAVTHSQD-------PPAEHRLRNLRRLGLVYFLYLFLFSGLEYTLS---------FLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISP----------------------------------------------GKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTG-------------------------------AQVCFTVCS-------------ALFLLPFLLLWK---------LKHPAETSKEE----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14728-1", "uniprot_id": "S75A1_HUMAN", "id": "Q14728-1", "name": "Solute carrier family 75 member 1", "aln": "-----MGWGGGGGCTPRPPIHQ-------------------QPP-ERRVVTVVFLG-------------------------------LLLDLLAFTLLLPLLPGLLESHGRAHDP-LYGSWQGGVDWFATAIGMPVEKRYNSVL-----FGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLE----------MAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQD-------PPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLS---------FLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHP----------------------------------------------GGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAG-------------------------------AQACFTTWS-------------GLFLLPFFLLQK---------LSYPAQTLKAE----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V395-1", "uniprot_id": "Q9V395_DROME", "id": "Q9V395-1", "name": "", "aln": "MADLRSRHNGTAAMEKQSHSQTGSHHHNNNKALDKEASENGKPEKSDPMIYIIFVS-------------------------------LLFDLLAFTIILPLLPSLLEHYRQNDSSGLYAVLTDRVRWFQQLLGAP--DRYISVL-----FGGFLGSMFSFLQFVASPIVGGLSDYYGRKPVLLACASGIALSYLIWACSSNFALFVLARFVGGISKG-NISLCMSVITDVSSVKTRGRGMALVGVAFSLGFIVGPMIGALFAIFSDKSGSTWFVLPSLLAFGLAVGDLVVLACCLRETLPKEKRVKEISSALSYGLQLLNFSAIFRFAAIKN----------VPKKD-IAALRSIGLVYFLYLFLYSGLEFTVT---------FLMYHKFGYTSMDQAKMFLTTGVIMTLLQGSVVRRLPE----------------------------------------------AKIKGYAIFSLYLIVPAFVVVGLAEGSRMLYAGMTLFAISTAFAVTCLTTLVSKYGNDDQKGSVLGIFRSLGALARALGPVVGCIAFWCVG-------------------------------SRITYIAGG-------------LLLIYPAMALQR-------------ARI--------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40475-1", "uniprot_id": "QDR1_YEAST", "id": "P40475-1", "name": "Quinidine resistance protein 1", "aln": "-----MTKQQTSVMRNASIAKEE--------------REGSDNNNVDRSSSDAIS----------------------DNDAERSNSHSEIDNESNFDMV---PYSRFSHKQKMLLVVQCAFTGFFSTVAGSIYYPVLTIIERKFNITEELANVTIVVYFIFQGVAPSIMGGLADTFGRRPIVLWAILAYFCACIGLACAHNYAQILALRCLQAAGISPVIAINSGIMGDVTTKVERGGYVGLVAGFQVVGTAFGALIGAGLSSKWG------WRAIFWFLAIGSGICLVFSTLLMPETKRTLVGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRT-SVDFLAPLKILHIREIDILLSIAGLQFSTWTTHQTALTIVLSKK-YNLSVAKIGLCFLPAGISTLTSIISAGRYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNSHYAFNLVEARLHPAFVTLLLSSIGFTAFGWCISVKTPLAAVLCTSAFASLFSNCILTFSTTLIVDLFPSKASTATGCLNLFRCLLSAIFIAALTKMVEKMRYG--------------------------GVFTFLSAITS-----------SSSLLLFYLLKNGK-------QLSFDRI-RANDKSAGRSVGKNSEKVST-----------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P40474-1", "uniprot_id": "QDR2_YEAST", "id": "P40474-1", "name": "Quinidine resistance protein 2", "aln": "-----MAGATSSIIRENDFEDEL--------------AESMQSYNRETADKLALT----------------------RTESVKP--------EPEITAP---PHSRFSRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWG------WRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILVLPTVRKSLHLDNPDYETLELPT-QLNLLAPFKILKAYEICILMLVAGLQFAMYTTHLTALSTALSKQ-YHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIENDPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLIVDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFG--------------------------GVFTFLGALTS-----------SSSILLFILLRKGK-------ELAFKRK-KQE-------LGVN-----------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53943-1", "uniprot_id": "AQR1_YEAST", "id": "P53943-1", "name": "Probable transporter AQR1", "aln": "-----MSRSNSIYTEDIEMYPTHNEQH--------LTREYTKPDGQTKSEKLNFEGAYINSHGTLSKTTTREIEGDLDSETSSHSSDDKVDPTQQITAETKAPYTLLSYGQKWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWD------WRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLLGPVRRRFKYDNPDYETLDPTIPKLDLSSAGKILVLPEIILSLFPSGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKFE-----------------QDKANGLIPQDA--EINMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNFVRCSLSTIFMGCFAKMKAAMTVG--------------------------GTFTFLCALVF-----------FFNFLMFIPMKYGM-------KWREDRLLKQQRQSWLNTLAVKAKKGTKRDQNDNHN---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . : * : : .. : .:* ..... *. :* **:*::: : * : .: :: * : . . . : : .:: *. *. :. . :. .*.::** :. : . :: : ** .: : .: . : : : : :** :: * : . :: *: * : * .: * .: : : : : . .:. . ..:. . : : . ", "identical_positions": 24, "similar_positions": 94, "identity": "3.58%" }, { "cls_id": "homologset.agr.HGNC:16895", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AYD0-1", "uniprot_id": "Q6AYD0_RAT", "id": "Q6AYD0-1", "name": "Leucine-rich repeat-containing protein 17", "aln": "---------------MRVAAILLLFCLCRTAEPRKPSPGALRSQGHPSRSRSSRAGGGRRGSSPVKRYAPGLPCDVYTYLHEKYLDCQERKL-------------------VYVLPDWP----QDLLHMLLARNKIRVLKNNMFSKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLR-----LYDNPWHCACELETLVS------------------MLQIPRNRNLG--------------NYAKCGSPPALR----------------NKKLLQLKPQELCDEEEKERLDP-------IPQVSGVPAVIRPEADST-LCHNYVFPIQTLDCKR--KELKKVPNNIP---PN--------IVKLDLSYNKISQLRPKEFEDVHELKKLNLSSN------------------------GLEFIDPAAFLGLIHLEELDLSN---NSLQSFDYGVLEDLYFLKLLW---------------------------------------------------LRDNPWRCDYSIHYLYYWLKHHYN---------------------------------VHYNG-----------------------------------------------------LECKTP------------EEYKGWSVGKYVRSYYEECPKDK---------------------------------------------------------------------------------------------------------------------------LPAYPETFDQDTEDDEWEKIHRDYPAKKHRVRITIVG---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CXD9-1", "uniprot_id": "LRC17_MOUSE", "id": "Q9CXD9-1", "name": "Leucine-rich repeat-containing protein 17", "aln": "---------------MRIVAILLLFCLCRAAEPRKSSPGVLRSQGNPSRSHGR---GGRRGSSPVKRYAPGLPCDVYTYLHEKYLDCQERKL-------------------VYVLPDWP----QDLLHMLLARNKIRVLKNNMFAKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEAFIYTPLLSYLR-----LYDNPWHCTCELETLIS------------------MLQIPRNRNLG--------------NYAKCGSPPALR----------------NKKLLQLKPQELCDEEEKEQLDP-------KPQVSGIPAVIRPEADST-LCHNYVFPIQTLDCKR--KELKKVPSNIP---PD--------IVKLDLSSNKIRQLRPKEFEDVHELKKLNLSSN------------------------GIEFIDPAAFLGLIHLEELDLSN---NSLQNFDYGVLEDLYFLKLLW---------------------------------------------------LRDNPWRCDYSIHYLYYWLKHHYN---------------------------------VHYNG-----------------------------------------------------LECKTP------------EEYKGWSVGKYVRSYYEECPKDK---------------------------------------------------------------------------------------------------------------------------LPAYPETFDQDTEDDEWQKIHRDHPAKKHRVRITIVG---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N6Y2-1", "uniprot_id": "LRC17_HUMAN", "id": "Q8N6Y2-1", "name": "Leucine-rich repeat-containing protein 17", "aln": "---------------MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGR-----AGGGRRGSNPVKRYAPGLPCDVYTYLHEKYLDCQERKL-------------------VYVLPGWP----QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLR-----LYDNPWHCTCEIETLIS------------------MLQIPRNRNLG--------------NYAKCESPQEQK----------------NKKLRQIKSEQLCNEEEKEQLDP-------KPQVSGRPPVIKPEVDST-FCHNYVFPIQTLDCKR--KELKKVPNNIP---PD--------IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSN------------------------GIEFIDPAAFLGLTHLEELDLSN---NSLQNFDYGVLEDLYFLKLLW---------------------------------------------------LRDNPWRCDYNIHYLYYWLKHHYN---------------------------------VHFNG-----------------------------------------------------LECKTP------------EEYKGWSVGKYIRSYYEECPKDK---------------------------------------------------------------------------------------------------------------------------LPAYPESFDQDTEDDEWEKKHRDHTAKKQSVIITIVG---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VS84-1", "uniprot_id": "Q9VS84_DROME", "id": "Q9VS84-1", "name": "", "aln": "---------------MTSLVYTVFHLASLQCSVRPEISPCTCETGKAWNHVELSCEKLESFNAVVDSLANKLNADTNIDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRN-AVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCN-HIKSLNSSLLPILKLKNANFS-FNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLN-GALAGLGNLRILNLAGN------------------------RLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDLVNPVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPTNYTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVELQDPNPPDTTVNQTALVPPVVLDPLQQDLERERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKANALEEDSESVHSNSVHAEYPHAAQSLQIPEEPPEE------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A6M3Q7U5-1", "uniprot_id": "A0A6M3Q7U5_DROME", "id": "A0A6M3Q7U5-1", "name": "", "aln": "MPDHTRVTATTRSRPWLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLP----FYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLN------------LVEFVRNDSFEG-------LKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFP-VDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIG------------ISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNG-------------LGMTLNYPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYRALKPWELPVKEADDEPEHLYERFDHYEYPDTHTMSKLKQAASLNHSNSSAGPSPVPPSSGKPHVVYVX----------------------------RGRGTGERVSQINTDIEMVGLNHLHLHHHHHNNNNNYRGCVQSAKASGQF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: . . * . : .: : * .:: : :. * : : :: : : * **: .* :. : .: :. * * * * * * : * : . .:.:* : : :* : : :::* : :::.. .: *: : . : . : : : : : *: . * :::: :. * : * : : :*: * *..* :*. . . .: : : : : : : : :. * : : : :: * * . . :. . . .* . . :: * * : * .: : ", "identical_positions": 34, "similar_positions": 114, "identity": "3.93%" }, { "cls_id": "homologset.agr.HGNC:16896", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VCH5-1", "uniprot_id": "RABEK_MOUSE", "id": "Q8VCH5-1", "name": "Rab9 effector protein with kelch motifs", "aln": "MRGLRQGIMKQLPILE----------PGDKPRK--------------ATWYTLTCPG----------------DRPCPRVGHSCSYFPPVGDAE-----SGKIFIVGGANPNQSFSDVHTMDLGTHQWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMSPED-----RTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGG--ERGAQPVEDVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAG-----TKLFIHGGLAGDKFFDDLHCIDIGDMS-----WQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWTVLQFDTSLPAGRLDHS-------MCVIPWPVMSTSENKDSDSV-ILTLQDEKGDAAEKAETQSGGPHEESPTTVLLCFVFGG-------------MNTEGEVYDDCLVTVVD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4V8F4-1", "uniprot_id": "RABEK_RAT", "id": "Q4V8F4-1", "name": "Rab9 effector protein with kelch motifs", "aln": "--------MKQLPILE----------PGDKPRK--------------AAWYTLTCPG----------------DKPCPRVGHSCSYFPPVGEAE-----KGKVFIVGGANPNQSFSDVHTMDLGTHRWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMNPEA-----RTWSTPEVTGCPPSPRTFHTSSAAIGNHLYVFGGG--ERGAQPVQDVKLHVFDANTLTWAQPETHGSPPSPRHGHAMVAAG-----TKLFIHGGLAGDRFFDDLHCIDIGDMS-----WQKLGPTGTAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHTEKQHWTILQFDTSLPPGRLDHS-------MCVIPWPVMSASDTEDSGSV-ILSLQDEKGDAAEKPETRSGGSREESPTTLLLCFVFGG-------------MNTEGEIYDDCLVTVVD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7Z6M1-1", "uniprot_id": "RABEK_HUMAN", "id": "Q7Z6M1-1", "name": "Rab9 effector protein with kelch motifs", "aln": "--------MKQLPVLE----------PGDKPRK--------------ATWYTLTVPG----------------DSPCARVGHSCSYLPPVGNAK-----RGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPET-----RTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGG--ERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAG-----TKLFIHGGLAGDRFYDDLHCIDISDMK-----WQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHS-------MCIIPWPVTCASEKEDSNSL-TLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGG-------------MNTEGEIYDDCIVTVVD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6GQN7-1", "uniprot_id": "RABEK_DANRE", "id": "Q6GQN7-1", "name": "Rab9 effector protein with kelch motifs", "aln": "--------MELIPVLE----------PEQKPQN--------------RHWYVLEPTG----------------AAPGVSVGHTCSFLPAAHHHDEDGGGKGKIVIVGGANPSGSFADSYIINLDTHQWDLPDWEGLQARYEHCSFTPESEPQSLWVFGGAEKSTNRNCVQALRFSDGGEGRRFWQSVQVTGVPPSGRTYHTNSACVGNRLFVFSGG--EAGSSAVTDAQLHVFDAVSVTWTQPDTTGTPPAQRHGHVITAVG-----SDIYIHGGMSGEKFHSDMFTLNTESLK-----WQKVKAKGDLPPGVAAHSSVTFNKNIFIFGGMTADGATNSMFKFQCDKQRWTLLKFEGDLPPGRLDHS-------MCLLPWRVK----MEDS----------------------------EHADVQHLCFVFGG-------------MDTQGVIFNDCLVTVLT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38853-1", "uniprot_id": "KEL1_YEAST", "id": "P38853-1", "name": "Kelch repeat-containing protein 1", "aln": "--------MAGFSFAKKFTHKKHGKTPSDASISDQSREASLSTPPNEKFFTKQETPQKGRQFSQGYHSNVNKTSSPPMFARKQVSESRIQPSAV-----PPQQRNVSGPSTTL-HKQLSKQREYTVWNRIKLQNSPFPRYRHVASAYVTDKNQIYVIGGLHDQSVYGDTWILTAFDNATR-FSTTTIDISEATPPPRVGHAAVLCG-NAFVVFGGDTHKVNKEGLMDDDIYLLNINSYKWTVPAPVGPRPLGRYGHKISIIATTQMKTKLYVFGGQFDDTYFNDLAVYDLSSFRRPDSHWEFLKPRTFTPPPITNFTMISYDSKLWVFGGDTLQGLVNDVFMYDPAINDWFIIDTTGEKPPPVQEHATVVYNDLMCVVGGKDEHDAYLNSVYFLNLKSRKWFKLPVFTAGIPQGRSGHSLTLLKNDKILIMGGDKFDYARVEEYDLHTSDIDMQRGTIVYTLDLARIKDLCPGVMDVPTDTPTPRNGNLDLATPVTPTSHQTKNMNVPISAAPLASAPSPAPKDFSDADRLNREVHNRNVSTEHQNQSHPVNSESHLIAEPNILTPYVPSESSQTPVMKITSNKPFDTPTIQKEPDLSETMDPTVGNQRIPSSIYGDNLTPANQIKNNSPILETLPSNEIKTPQNGNIEEIKHLPDADEKIDSTTTFDQEINGDKLGTSSMSKVEEDGNVADEDDEIGVAQMASSPSKDQFKIKHYNESSELSQNNTEIDKLSEPVDITIKKSDTAGHDSANHVIDASDEKNVSPMGDVPTDTKNEEASVPINRDATTEVVDRALFEKLRSELQSLKELTHEKALEAGAHIKELETELWQLKSQKNSGTTKEIDELDSVRLQSKCEILEADNHSLEDKVNELEELVNSKFLDIENLNEVIQFQNEKIKSLELEPNYKEKLEELQIEHENLSRENERLKNESKQHNEDIINNVANYSSQLGSLISHWKENRANSSFLESSSSLISVSDENGEKTVGEPYGDQSRHHRVVINKLTNRLDDLLERSQELTISKEKLSSEYHALKMEHSSLSQDVLVKENEIKKIQNDYKESISSMDSASKALMVSQRELEKYKSLNKKLIDELDELKFKNGVCSENFENGLRSTEESSNNVKNSNSIRENQFNIKINDLKAELFITNQERDDLKSEVLELKKRLLNLENNTKQVNEDADSDLL", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P50090-1", "uniprot_id": "KEL2_YEAST", "id": "P50090-1", "name": "Kelch repeat-containing protein 2", "aln": "--------MVPFKLTN--------KVPTDTGPS---------------LISAQSVPR------------------PIVFMDNRNNTRIVTPTLP-----PNQHRGISGASTALPWSPESKNTGKYIWNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGLHDQSVYGDVWQIAANADGTS-FTSKRIDIDQNTPPPRVGHASTICG-NAYVVFGGDTHKLNKNGLLDDDLYLFNINSYKWTIPQPIGRRPLGRYGHKISIIASNPMQTKLYLFGGQVDETYFNDLVVFDLSSFRRPNSHWEFLEPVGDLPPPLTNHTMVAYDNKLWVFGGETPKTISNDTYRYDPAQSEWSKVKTTGEKPPPIQEHASVVYKHLMCVLGGKDTHNAYSNDVYFLNLLSLKWYKLPRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQTSETDQGEGTLLYTLDLSSLNELCPGIMCES--------------------LHAGESFSNSLSGG------------FTPSK-----------STESENQ-----------EIINILTPRLPDS-------KVLSYN---------------DIDEGAG--------------------SYSSALDD--------------KAFERKSDREEKKPQSSKVDSSINKESPGTG------------------------------------------------------------IKVS----------------KKNFPVLRGLTVDSE-EYGSSSYKDTSCQKGIPKNLFDDLNLNLQTLRLEAQQKELETARHISQLEKEVQRLMVIKEASKD---SNFQTARLKN----LEIQKTFLESRINDLKNLLMVKLSQASKLCDQITIQNNGLKTCSEHVTIKRDIIDLENKCDVLKRQNEILVNNMQKITPELHTYLNESSCYLGKLLKSYP------------TSARPPSSEK----------DNQIYEKDSLNKIEKVINEMHETVR----AKEKLHLETQKLNDERDSLRANLLDNNNKLDALRKLSDGSSKSMDLTKKAIHLSQSELEKYRKNNDDLQKEIDRIKTEQAEQDD--------KQEQRGAITHGN--FDAFHRMKINNLKAELYMSKENRDSLKDELLALKKKLYTLEQKK------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : . : * : . . * : . : :.*... :. .**.* : . ::* ** ... . : :: .*. *. *: . * **.*. : . . : * .::::: : .*: * . * * *:** : . :.:::.** .: :..*: : .: *: : . * : .: :: . ::::*** * : : :. . * :. *. :*: **:: :. :::** :: . :: .: ", "identical_positions": 41, "similar_positions": 105, "identity": "3.47%" }, { "cls_id": "homologset.agr.HGNC:16897", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P52759-1", "uniprot_id": "RIDA_RAT", "id": "P52759-1", "name": "2-iminobutanoate/2-iminopropanoate deaminase", "aln": "---------------MSSIIRKVISTSKAPAAIGAYSQAVLVDRTIYVSGQIGMDPSSGQLVPGGVAEEAKQALKNLGEILKAAGCDFTNVVKTTVLLADINDFGTVNEIYKTYFQGNLPARAAYQVAALPKGSRIEIEAIAVQGPFTTAGL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P52758-1", "uniprot_id": "RIDA_HUMAN", "id": "P52758-1", "name": "2-iminobutanoate/2-iminopropanoate deaminase", "aln": "---------------MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P52760-1", "uniprot_id": "RIDA_MOUSE", "id": "P52760-1", "name": "2-iminobutanoate/2-iminopropanoate deaminase", "aln": "---------------MSSIIRKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAVQGPFIKA---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9V3W0-1", "uniprot_id": "UK114_DROME", "id": "Q9V3W0-1", "name": "RutC family protein UK114", "aln": "---------------MSTIVRKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIALTGSVETKTVQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40185-1", "uniprot_id": "MMF1_YEAST", "id": "P40185-1", "name": "Protein MMF1, mitochondrial", "aln": "MFLRNSVLRTAPVLRRGITTLTPVSTKLAPPAAASYSQAMKANNFVYVSGQIPYTPDN-KPVQGSISEKAEQVFQNVKNILAESNSSLDNIVKVNVFLADMKNFAEFNSVYAKHFHTHKPARSCVGVASLPLNVDLEMEVIAVEKN-------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P40037-1", "uniprot_id": "HMF1_YEAST", "id": "P40037-1", "name": "Protein HMF1", "aln": "----------------MVTTLTPVICESAPAAAASYSHAMKVNNLIFLSGQIPVTPDN-KLVEGSIADKAEQVIQNIKNVLEASNSSLDRVVKVNIFLADINHFAEFNSVYAKYFNTHKPARSCVAVAALPLGVDMEMEAIAAERD-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *. . ..*.:*: .:. :::** : .. : * *. ::*::.::*: :* :.... .::* .::* *::.* .*.:* *: ***:. ** ** . :*:* :* ", "identical_positions": 27, "similar_positions": 52, "identity": "17.65%" }, { "cls_id": "homologset.agr.HGNC:16898", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q64355-1", "uniprot_id": "EFS_MOUSE", "id": "Q64355-1", "name": "Embryonal Fyn-associated substrate", "aln": "MAIATSAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLCPASPTQPG-SSCPTPER--------GCEEQE-VYVIPP--------------------------PARPCSAS-------------GLPARSCSPSS--------------------------------DSIYKVP---------RGNGMQLTASRDVAE-----VYDVP-PNILRAPSSCPYDSPAS----------------------FSCPVAPVVP-QPPREDEAP--YDVPLALKPPAELERDPEWEG--------------------------------------------------------------GREPGPP------------------------LYAAPS----------------------NLKRASALLN---------------------------------------LYEAPEELLAN----------------------------------GESRD-------------------------------------------------ADEGIYDVPLLGPE-PPSPEPPVASSSTDLD-------------TVAQLPTR----------------------------------------------SSPP---------------------QHRPRLPSTESLSRRPLPALPVSEAPAPSPAPSPAPGRKGS-IQDRPLPPPPPCLPGYGGLKPEGDPECREVANDPAGPHNEYEGIPMA----EEYDYVHLKGVDTAQGSRPLDKAFPVDPELLERGLAERKEALSPEEPLVLSTGDLQLLHFYAGQCQSHYSALQAAVAALVASTQANQPPCLFVPHGKRVVVAAHRLVFVGDTLGRLAASAALRAQVGAAGTMLAQTLRATVLAVKGAALGYPSDTAVQEMARCVAELAGQALRFTTLLDGLLP--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7F497-1", "uniprot_id": "F7F497_RAT", "id": "F7F497-1", "name": "", "aln": "MAIATSAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPASPAPKPSLCPAPPTQPGCSSCPTPER--------GCEEQE-VYVIPP--------------------------PARPCSAS-------------GLPARSCSPSS--------------------------------DSIYKVP---------RVNGIQLTAPRDVGE-----VYDVP-PNILRAPSNCPYDSPAS----------------------FSCPATPVVP-QPPGEDEAP--YDVPLALKSPAEMEPDLEWEG--------------------------------------------------------------GREPGPP------------------------LYAAPS----------------------NLKRASALLN---------------------------------------LYEAPEELLAN----------------------------------GESRD-------------------------------------------------ADEGIYDVPLLGPE-PPSPEPPAASSSADPD-------------TVAQLLTR----------------------------------------------SPPP---------------------QHRPRLPSTESLSRRPLPALPVSEAPAPSPAPSPAPGRKGS-IQDRPLPPPPPCLPGYGGLKPEGDPECREVDSDSGGPHNEYEGIPMA----EEYDYVHLKGVDKAQGSRPLDNAFPADPELLERGLVEQKEALSPEEPLVLSTGDLQLLHFYAGQCQSHYSALQTAVAALMSSTQANQPPCLFVPHGKRVVVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTVLAQTLRATVLAVKGAALGYPSDTAVQEMARCVAELAGQALRFTTLLAGLLP--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O43281-1", "uniprot_id": "EFS_HUMAN", "id": "O43281-1", "name": "Embryonal Fyn-associated substrate", "aln": "MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPG-SPYPAPDH--------SNEDQE-VYVVPP--------------------------PARPCPTS-------------GPPAGPCPPSP--------------------------------DLIYKIP---------RASGTQLAAPRDALE-----VYDVP-PTALRVPSSGPYDCPAS----------------------FSHPLTRVAP-QPPGEDDAP--YDVPLTPKPPAELEPDLEWEG--------------------------------------------------------------GREPGPP------------------------IYAAPS----------------------NLKRASALLN---------------------------------------LYEAPEELLAD----------------------------------GEGGG-------------------------------------------------TDEGIYDVPLLGPEAPPSPEPPGALASHDQD-------------TLAQLLAR----------------------------------------------SPPP---------------------PHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGS-IQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMA----EEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLAP--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0G2KR69-1", "uniprot_id": "A0A0G2KR69_DANRE", "id": "A0A0G2KR69-1", "name": "", "aln": "--MSLSTVLAKALFDNAAESPEELAFRKGDILMVLNQEQDGGP-GWWLCSLHGRQGIAPANRLRLLQSTQAPASSAGTDARRAPSVDSVHLPSSQQGKVNGLSAEDSDGVYLSPPSLAEGVYQSPGAAPAQCRSGELRHSDAGRPRSHSSSGTRPRPDWGDVGVAGRPRSPSLRGRGGESGTLYQTPSSPVPLAAQHRSQVALPTDSVYLTPSAVSRSAAETAGESRYLSPRDASAGHSDGCYLVPRPAVTTLTSENLYQTPTSGAPVAGQCVAGVTSRLVDKIAPKSSPSSSSSPSQSKSGQDAPGMYQTPTPPGGAISRTPQSDRKNPAGTVVVSNASTPGQNIKQTPPSGRGSQKGTTSTAPVGRGKLRESPLLTRTGKSGVPSSPNFGRKPPPPAPPVRSVTRKDLPQSSAIPATKPVLQANPAPPPTNMLEEERQGSKSGQTQADEMKNNSEMLSKRDSASSQEEKLSEEVYDTPPTNRWQHPVSIVPSEEDDGIYNTPRALIVHNDQASEIYDVPTLALNSSEHQQQTYNIPGSAAAIGDAEDEDVYSVPSLPGLPLEASELSGLTVETVVNGRSYSISSLRKQDAIDDVSEPDGGIYDMPALNLEIPTRRLSVSSTGSGDIQWKTSLSALVQSALTSASLPTTPSRDFAAALAEILSIWKAGHVGDIPPVLQHAWSRLSDLLPALSVCGTAPPADGLLSMVRGALEDSAALLQSQTRPRLPSQDSLSRRPLPALPVAEVK---PIAGDMGSRKGSWIQERPLPPPPPAAFPLPPAPVSLVPTVGRMEDEEPG--NEYAGIGLTPTPPPSYPVGDSVGYVKLQG-KPEPPPDTHTEHSSSQLITSTDNKLSPSPPVSMSLEDSELLSFYSSQSLSHLSCLADAIDSLFTSVQGNQPPRVFVSRGKSLIVTAHKLVFIGDTLARLLSSSDLRAKVTTSSGRLCQALKAVVVATKGAAQNYPSVPATQEMVDRVADLSQHAAGFSGLLQRLAEIS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: *: **:**:**:****:**:**:**:* **::* ** ** ******:***.****::** : ** .* . . *. .. *. . *:.: **: ** ..** . * * .. . .** * :* * . : :.**. * ** * .*. *: *:* * * : * *. ::** *:.* . . . : : :. **:* ** : * *: ::*. * :*. :*::*. *:.. *:. . .* ****:* *. * *. . : .* * : * *.* : :.** ****** :************.*. * .. .**** **:******** . * .: .: * *** ** :: .* . * . ** :* . . . .: : .: *** *: :* * :** **:.*. ** *.* *: :*.:*.*.**** :**.:.* ::*:**:***:****.** :*: ***:* ::. * *:*:*.*:*.**** .*** .* ***. *::*: :* *: ** * ", "identical_positions": 220, "similar_positions": 157, "identity": "22.02%" }, { "cls_id": "homologset.agr.HGNC:169", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P61161-1", "uniprot_id": "ARP2_MOUSE", "id": "P61161-1", "name": "Actin-related protein 2", "aln": "MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVG-NIEIK-----DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P61160-1", "uniprot_id": "ARP2_HUMAN", "id": "P61160-1", "name": "Actin-related protein 2", "aln": "MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVG-NIEIK-----DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5M7U6-1", "uniprot_id": "ARP2_RAT", "id": "Q5M7U6-1", "name": "Actin-related protein 2", "aln": "MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVG-NIEIK-----DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7SXW6-1", "uniprot_id": "ARP2A_DANRE", "id": "Q7SXW6-1", "name": "Actin-related protein 2-A", "aln": "MDSQGKKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTAKVG-NIEIK-----DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDSRNCKILLTEPPMNPTKNREKIIEVMFETYQFSGVYIAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMMKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRVIKVGGERFGAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRAEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVDKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTREEYQEKGTRVLEKLGVTVR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q56A35-1", "uniprot_id": "ARP2B_DANRE", "id": "Q56A35-1", "name": "Actin-related protein 2-B", "aln": "MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTAKVG-NIEIK-----DLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNINSRDCKILLTEPPMNPTKNREKIIEVMFETYQFTGVYIAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMMKENLCYVGYNIEQEQKLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRAEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVDKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWLTREEYQEKGVRVLEKLGVTVR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P45888-1", "uniprot_id": "ARP2_DROME", "id": "P45888-1", "name": "Actin-related protein 2", "aln": "MDSKGRNVIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIG-DIEVKDLHVDDLMVGDEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQKLQKISH", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32381-1", "uniprot_id": "ARP2_YEAST", "id": "P32381-1", "name": "Actin-related protein 2", "aln": "MDP--HNPIVLDQGTGFVKIGRAGENFPDYTFPSIVGRPILRAEERASVATPLK-----DIMIGDEASEVRSYLQISYPMENGIIKNWTDMELLWDYAFFEQMKLPSTSNGKILLTEPPMNPLKNREKMCEVMFEKYDFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLSHLTRRLDVAGRDVTRHLIDLLSRRGYAFNRTADFETVRQIKEKLCYVSYDLDLDTKLARETTALVESYELPDGRTIKVGQERFEAPECLFQPGLVDVEQPGVGELLFNTVQSADVDIRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWFSRVLHNDPSRLDKFKVRIEDPPRRKHMVFIGGAVLASIMADKDHMWLSKQEWQESGPSAMTKFGPR--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. :: :* *:****** * **.*** : **::****::*: : . :* *:*:*****::** *::.******:::** ** :***:* : .. . *********** *****: *****.* * ..*:******:****** :***:********* **** . *.*******:****:**:**.** ******::******* :**:***:.*::: : :** ***.***** ***** **** *** ***.**** *::** *:.** ***:*:**:* *..:** *******:**********:*:***::.***:.* .:* ***:*********.***:******.: *:* :*::::*:**.* .: *: ", "identical_positions": 237, "similar_positions": 94, "identity": "59.25%" }, { "cls_id": "homologset.agr.HGNC:1690", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QWK4-1", "uniprot_id": "CD5L_MOUSE", "id": "Q9QWK4-1", "name": "CD5 antigen-like", "aln": "MAPLFNLMLAILSIFVGSCFSESPTKVQLVGGAHRCEGRVEVEHNGQWGTVCDDGWDRRDVAVVCRELNCGAVIQTPRGASYQPPAS-EQRVLIQGVDCNGTEDTLAQCELNYDVFDCSHEEDAGAQCENPDSDLLFIPEDVRLVDGPGHCQGRVEVLHQSQWSTVCKAGWNLQVSKVVCRQLGCGRALLTYGSCNKNTQGKGPIWMGKMSCSGQEANLRSCLLSRLENN-CTHGEDTWMECEDPFELKLVGGDTPCSG------RLEVLHKGSWGSVCDDNWGEKEDQVVCKQLGCGKSLHPSPKT------RKIYGPGAGRIWLDDVNCSGKEQSLEFCRH----RLWGYHDCTHKEDVEVICTDFDV--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43866-1", "uniprot_id": "CD5L_HUMAN", "id": "O43866-1", "name": "CD5 antigen-like", "aln": "MALLFSLILAICTRPG---FLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQE-EVYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSG------RLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRD------RKCYGPGVGRIWLDNVRCSGEEQSLEQCQH----RFWGFHDCTHQEDVAVICSG-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1M8T7-1", "uniprot_id": "F1M8T7_RAT", "id": "F1M8T7-1", "name": "", "aln": "MLPWFLLLICGAAQFSVNKIVFSIQLDEMLS--LPCEPAGNPVSDVSLKTKPPGEWVMEGNKLVLICSVANTTENITYLWYRGALGLNLEKKTLPSITAEFEISEVKQSDVD--QYYCAADNGHGPVLSELVNINVRVPVSRPVLTFVDTGT-QAVLGDLVELHCKALRGSPPIFYQFYHENIILGNSSDHSGGGASFNFSLTAEHSGNFSCEASNGQGVQR-SEVVALNLTGLSLVPTVNGIGNLSSGLTGWLIGCLGPIATVLIFCYWLKRKIGRQSDDPLRSPP-QTVLQESNYHNSPDPGHPEPVYENVNAVSGDEVYSLVYHTQQELGPTAAQHVSTHGASESFQLSSGIYSKPRINIVYVDYEDTM", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * *::. : : * .::. ** : . . * . * .. :: ..:. . . . :: : .: . . : *.: : : *: ::. *. .: . :* . : . :. : . : . * :. .:: *.: . . . .::**.. :. . * . . :: . :. *.* * * : * * .** . *.* :: . :* *. . * . : . . * : . . * : . : : :: . ", "identical_positions": 32, "similar_positions": 104, "identity": "8.6%" }, { "cls_id": "homologset.agr.HGNC:16900", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4QQU6-1", "uniprot_id": "SPF30_RAT", "id": "Q4QQU6-1", "name": "Survival of motor neuron-related-splicing factor 30", "aln": "MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLTSSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAVYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGT7-1", "uniprot_id": "SPF30_MOUSE", "id": "Q8BGT7-1", "name": "Survival of motor neuron-related-splicing factor 30", "aln": "MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAVYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75940-1", "uniprot_id": "SPF30_HUMAN", "id": "O75940-1", "name": "Survival of motor neuron-related-splicing factor 30", "aln": "MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZV80-1", "uniprot_id": "SPF30_DANRE", "id": "Q7ZV80-1", "name": "Survival of motor neuron-related-splicing factor 30", "aln": "MSEELMKQLSNYKAQLQQVEAALSIDPDNEDLLKLQKDLQEVIELTKDLLTSQPAEGTTSTKSSETVAPSHSWRVGDHCMATWSQDGQVYEAEIEEIDNENGTAAITFAGYGNAEVMPLHMLKKVEEGRIRDEIDG-KPKSKKELQAEQREYKKKKAQKKVQRMKELEQEREDQKSKWQQFNNKAYSKNKKGQVKRSIFASPESVNGKVGVGTCGIADKPMTQYNDTSKYNVRHLMPQ", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:* ***:.************* : :*******:**************::**:* :*:.* :. *:***:***:***.**:*** *********:********** ****** ** ** ***** .* .* ** ****: *:********* **.**:*********** *******:*********************.******************:*************", "identical_positions": 187, "similar_positions": 29, "identity": "78.57%" }, { "cls_id": "homologset.agr.HGNC:16901", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63638-1", "uniprot_id": "SPEG_RAT", "id": "Q63638-1", "name": "Striated muscle-specific serine/threonine-protein kinase", "aln": "------MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRG----VLVTGAGAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPEPSLSWFRDGQLLPTPVPEPSCLWLRNCGAQDAGVYSCSAQNERGKASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSIPPSGLRREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGSSAQPPATPTSPHRCTQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAAWDTPGASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRRSTSREELVR--SHESLRATLQRAPSPREPGEPPLFSRPSIPKTSR-----------------------------------------------AVSPAATQPPPPSGAGKSGDETGRP-----------------------RSRGPVGRTEPG---EGPQQEIKRRDQFPLTRSRAIQECRSPVPPFTADPPESRTKAPSARKREPPAQAVR-----------FLPWATPGVEDSVLP---QTLEKNRAGPEAEKRLRRGPEEDGPWG----------------AWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSVLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQASCASSLAVRPGASTSP---------FSSPITSDEEYLSPPEEFPEPGETWSRTPTMKPSPSQDRDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTVKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNESENLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEH--GDLERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPEWAATGLKKGLHHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEPRTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSITLELAEAPRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVVLSAGSQDGGVYTCTARNLAGEVSCKAELSVHSAQTAMEVEGVGEDEE---HRGRRLSDYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGIGYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIP---------------------------------------TEDEALGTPEAGAATPMDWQEQGRAPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPG----------RSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGG-----------RARDPRMARAASSEAAPHHQP--PPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLG-------------------------ARRLQESPSLSALSETQPPSPALPSAP------------KPSITKSPEPSAATSRDSPQPPAPQPVPEKIPEPKPEPVRAAKPAQ------------------------------------PPLALQ--------------------------------MPAQSLTPYAQIMQSLQLSSPTLSPQ----VPPSEPKPHAAVFARVASPPPGASEKRVPSARI-----------PPVLAEKVRVPTVP-------------PRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFRGAED-DGIYRPSPAGTPLELVRR--PERSRSVQDLRVAGEPG---LVRRLSLSLSQKLRRTPPGQ-----------RHPAWES-RSGDGESSE----------------GGSSARGSPVLAVRRRLSSTLERLSSRLQ-RSGSSED------------------------------------------------SGG----ASGRSTPLFGRLRRATSEGESLRRLGVPHNQLASQTG--ATTPSAESLGSEASGTSGSSAPGESRSR-HRWGLSRLRKDKGLSQPNLSASVQEDLG----HQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPTPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRASKRHAGLYECSATNVLGSITSSCTVAVARTPGKLAPPEVPQTYCDTALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRGTQ-----DSPAQSAAAPRDAPVTSGPTRAPPPDSPTSLVPTPPLAPQVSQASTLSP------------------------STSSMSANQALSSLKAVGP-PPATPPRKHRGLLATQQAEPSPPSILVTPSEHKSFVPDTGTLTPTSSPQGVKPAPSSSSLYMVTSFVSAPPDPQPP----------APEPPPEPTKVTVRSLSPAKEVVSSP-------------------------TPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGRHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVRGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGSP------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q62407-1", "uniprot_id": "SPEG_MOUSE", "id": "Q62407-1", "name": "Striated muscle-specific serine/threonine-protein kinase", "aln": "------MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRG----VLVTGDGAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPPAPEPSCLWLRSCGAQDAGVYSCSAQNERGQASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSIPPSGLHREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGPSTQPPATPTSPHRRAQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAAWGTPEASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRRSTSREELVR--SHESLRATLQRAPSPREPGEPPLFSRPSTPKTSR-----------------------------------------------AVSPAATQPPPPSGAGKSGDEPGRP-----------------------RSRGPVGRTEPG---EGPQQEIKRRDQFPLTRSRAIQECRSPVPPYTADPPESRTKAPSGRKREPPAQAVR-----------FLPWATPGVEDSVLP---QTLEKNRAGPEAEKRLRRGPEEDGPWG----------------PWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSMLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQATCASSLAVRPGGSTSP---------FSSPITSDEEYLSPPEEFPEPGETWPRTPTMKLSPSQDHDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNEGDNLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEH--GDLERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPEVVAVTGRMVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPAWAATGLKKGIQHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEARTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSVTLELAEAPRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVLLSAGSQDGGVYTCTARNLAGEVSCKAELSVLSAQTAMEVEGVGEDEE---HRGRRLSDYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIP---------------------------------------TEDEALGTPEAGAATPMDWQEQERTPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPG----------RSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGG-----------RARDPRMARAASSEAAPHHQP--PPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLG-------------------------ARRLQESPSLSALSETQPPSPARPSVP------------KLSITKSPEPSAVTSRDSPQPPEPQPVPEKVPEPKPEPVRAAKPAQ------------------------------------PPLALQ--------------------------------MPTQPLTPYAQIMQSLQLSSPTLSPQD-PAVPPSEPKPHAAVFARVASPPPGVSEKRVPSART-----------PPVLAEKARVPTVP-------------PRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFRGAED-DGIYRPSPAGTPLELVRR--PERSRSVQDLRVAGEPG---LVRRLSLSLSQKLRRTPPGQ-----------RHPAWES-RSGDGESSE----------------GGSSARASPVLAVRRRLSSTLERLSSRLQ-RSGSSED------------------------------------------------SGG----ASGRSTPLFGRLRRATSEGESLRRLGVPHNQLGSQTG--ATTPSAESLGSEASGTSGSSAPGESRSR-HRWGLSRLRKDKGLSQPNLSSSVQEDLG----HQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARIPGKLAPPEVPQTYHDTALVVWKPGDGRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRGTP-----DSPAQPAAAPRDAPVTSGPTRAPPPDSPTSLAPTPALAPPASQASTLSP------------------------STSSMSANQALSSLKAVGP-PPATPPRKHRGLLATQQAEPSPPSIVVTPSEPRSFVPDTGTLTPTSSPQGVKPAPSSTSLYMVTSFVSAPPAPQAP----------APEPPPEPTKVTVRSLSPAKEVVSSP-------------------------TPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGSP------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15772-5", "uniprot_id": "SPEG_HUMAN", "id": "Q15772-5", "name": "Striated muscle preferentially expressed protein kinase", "aln": "------MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGGG----APVA--VAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDDISDVQGTQRLELRDDGAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSVPQSGLRREEPDLQPQLASEAPR-RPAQPPPSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTT-EEKRGKKSKSSGPSLAGTAESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELRAP-GSVAERRRLFQQKAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVR--SHESLRATLQRAPSPREPGEPPLFSRPSTPKTSR-----------------------------------------------AVSPAAAQPPSPSSAEKPGDEPGRP-----------------------RSRGPAGRTEPG---EGPQQEVRRRDQFPLTRSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVR-----------FLPWATPGLEGAAVP---QTLEKNRAGPEAEKRLRRGPEEDGPWG----------------PWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELGQATCAASLTVRPGGSTSP---------FSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQ--GELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGEDED---HRGRRLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTQAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIP---------------------------------------TEDEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELG----------RGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGG-----------RARDPRMARAASSEAAPHHQP--PLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLG-------------------------ARRLQESPSLSALSEAQPSSPARPSAP------------KPSTPKSAEPSATTPSDAPQPPAPQPAQDKAPEPRPEPVRASKPAP------------------------------------PPQALQ--------------------------------TLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGG-----------PPVLAEKARVPTVP-------------PRPGSSLSSSIENLESEAVFEAKFKRSRESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLELVRR--PERSRSVQDLRAVGEPG---LVRRLSLSLSQRLRRTPPAQ-----------RHPAWEA-RGGDGESSE----------------GGSSARGSPVLAMRRRLSFTLERLSSRLQ-RSGSSED------------------------------------------------SGG----ASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQAG--ATTPSAESLGSEASATSGSSAPGESRSR-LRWGFSRPRKDKGLSPPNLSASVQEELG----HQYVRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANRAGQGPFSNSSEKVFVRGTQ-----DSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSP------------------------SSPPTPPSQALSSLKAVGP-PPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPP----------APEPPPEPTKVTVQSLSPAKEVVSSPGSSPRSS-----------------PRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGGP------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q696W0-1", "uniprot_id": "SPEG_DANRE", "id": "Q696W0-1", "name": "Striated muscle preferentially expressed protein kinase", "aln": "---------MRKVTEEKR-----HSSSMNSSTVETS-------------FIAAPPVFLRKLKWAAVAAGCDVRLRVCVGGNPRPTLHWYHNDDPLVIDHEDYDGLWIRDCQQADGGLYTCVAVNHLGEARTSAVLAVLDLEE----------------------------------------------DSNSTEDES---AEPHVSMEMKEQFMP-------PQGEAINSQPTGRGRAMLSHIP-------------SDGLVVEREMR----------ALGSRAPGLQEPLSPGRGQLDFKTS-------EATP------FVQTQPPHKAQASITKSDVDATIDSTATKIKGTKTAMNG-----AEVSIKSSKITGSHQSGG-------------LQDPSSIQTPKVSQASSKILDRVRAFEEQSHNSNMP---KVSSRLSWGFNRTSSCNSEDETCKAGKFQANT--------KSDVALKRSFFKQKASSLEEQSTYVQKN--FQSKLSEELHRIKKLVGKSNIKKAFSMEQLTQTDK--QSSVSTESVPTQVIQKSEETG----------------------------------------------KHFTNLKAVPDAKERWTTLPKEQSSRLPKIN----------------LADKTKQPENETPP----EMNENQENNSKPTQLLDGQVLNEKVSFIPGQCSPMLPRTNVS-RKWPKSPAQPMVK-------DGLVQAPQKPPRLLES----------ISTPPTPFKMTIPTIVVENKPVD------------------EELDQKEGQIMRQNR------DALDDFHTSVEKSIAEAPMSELPRKDALGTAG-SELLQCIIKEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVARAPAESLLIITRPMQDVKVKAGETALLECFIAGSQAVDVDWLANGKLIQPALFDCKMQFDGHRCRLLFKSAHENDSGCYTCKLSTAKEELICTANLLVIPSKEPLFTRKLEVLEAIEGRSAQFDCKVSGCPPPEVTWTHCEKPLVESDNIHILNVNGHHSLLITHVNKESEGLYTAIAQNVHGKAASSAELYVQEPRPAISTHMSRLEKMPSIPEEPEVPEGEVERRTMPDFIKPLSDLEVIEGKEAVLKCRVTGLPYPKITWYHNGKKIESTNDRKMTQYRDVHSLVIQSVCHDHSGVYKCVISNKVGKAACYAHLYVAVSLPEPPDGPPVIESVTGRMILLSWKKPKNLDPSIDPASLMYVVQQQVLGSTQWTTIASSLTDTSYTVTSLSKGVCYSFRVLSTTGKTLSKPSQPTDLVQLVDRGEYFRKAPVIIDKPDIVYAVENQPVTITITINHVQATCTWK-RRGVVLVNKLGALEMTTPDDDQHALHIAKVKSTDVGQLIFMANNQYGSDLGTLQLVIAVPPIFETIMEDLDVCVGETCHFAVVVDGKPDPDILWYKDGVLLAESSHLTFVYDDRECSLVVLNAQPEDVGVYTCTAKNLAGSVSCKAELTVHTAQNVEEEEEQMEDEATILRRMRMLTDYYDIHKEIGRGAFSYVKRVKHKN-DQSFAAKFISVRAKKKTCALRELALLAELDHKSIVRFHDAFEKRRVVIILTELCHEELLERITKRTTILESEVQSIIRQLLEGIEYLHQNDIIHLDLKPENILMADQKT--DQIRICDFGNALKVKPNEELYCKYGIPEFIAPEIVNQSPISKSTDIWPVGVITYLCLTGVSPFAGENDRDTLLNIRNYNVAFEESMFKDLCREAKGFIIKVLVSNKLRPDATECLLHPWFKSLTKGKSINTTLHKQVLARRKWQCSLIRYGSKMVMRSISELLDDSSSHVSLAVPRNLKDGSPPPSSSSDSDEDIDELPFIPMPHTMMFSGSRMSLTEIH--------------------------EVDDKVIRGSNESYKKNLNQLDDIPESQIIAGQKNEDYLKNPKRTDNCLQRGSSVEVDQVASKTRRGLMRRGSSADSALLLQITPEDNEIKDTTEDSQKHMKKAVSMELP-HRSSSPKTAKLSKE-----DYALKLDLMRQRLLKGGTVNKNMSGLRGPLLETLGVDDERRTSSLDRNFRNARLNASGDSGTFNNDSSEETYQKPAFRKRSSLRDENSESISLHRRSGAPLEIPSSSTG------------------DHNVLKIKSTILDENKANLPPLFPRDISSKPPTP---------VLENKQVSKEEANSDVLIMNSSRSAFNLEDTEIKVEEMKEQDSVPENMN----------------------------------KSTEFPLD-------------------------------ILPHDISSNYCSKLQ------ANGKKAS-FLTPLPTPVLK-------------ISQPNIQPTAG----------RPGVFASAFSAHQP-------------------NLRSDIKNIDSEEIFEARFKK-RESSLAHGLKRLTRTKSEESSPVPQRKSDEVVYRPGPVGSPLEFGSTGLKEKSKSVQDLREVDKEVGLGLIGRFSMRARKLQPIDKKEKKEISDSVTN-KRQLTWATRRSKSLDKKENFETNKEN-----LEKDTKKIAESPVLAVRRKFESNVSGIFDRVHSRSKDRKDKETKPHIDAEAPNVEKQDMKKINDSPVLALRKKFETKVSGISYRKQSQSEGEGTKFEGQKTPLFSRHHRSQSDGLIHKKMDIPENQLPLQTTTISSKETLNSSSSAHSIESSQTPETEIRSRWDRWGLSRGKRDRTPSNSRAPATPK---------------EDFPPVFHIALKDHVLLEGNPVTLSCLPAGSPEPKILWLKDKKPLKLCDGMNLEACPDGRQLLMIMNISKKDAGIYECVATNNLASVTTSCILTLACIPNCPGTPEIRQIYNNTVLVQWKPSDTKVPCTYTIEKKFDGDDKWLTEATGVTDCFFNSSELPSGSTIRFRVACVNKAGQSPYSNESDGVSIDTK-----------VTPQHQPAKMKTHSPASFPAMTAAVATSAFSLSLPSVFSQSIS-------------------------PTPAQSADVSNTFLEVQS------------SPKMSTPLDLPKPASSVNTMPPITQTQTVSPRSYTAPP-SIGRSISPVPTYVPATCSLAPTP-------------------VSPSVIVVSSISPIGEGASSPTPETPTGQAVSS-------------TKSETTLRQGVPQKPYSFLDEKARGRFGVIRDCRENATGKMFIAKIIPYDQQTKQTIIKEYEILKSLRCERIMALHEAYITPRYLVLITEYCSGKEILQNLIDRFCYSEDDVVGFIVQILQGLEYLHNCKILHLDIKPDNIMVTNLNVIKIIDFGSAQRFNPLSLQQCSRYLGTLEYMAPEMLKGDLVGPPADIWSLGVLSYIMLSGRHPFEDKDPQLTEAKIHEAKFDSTKLYPKVSQSASTFLKKILNSYPWCRPTIKDCLNHSWLHDSYLKKLRRQTLTFTTTRLKEFMGEHQRRCAESATKHKVILRVYQGGPSSPASPTKYTTQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9QG49-1", "uniprot_id": "A0A8M9QG49_DANRE", "id": "A0A8M9QG49-1", "name": "non-specific serine/threonine protein kinase", "aln": "MRKAEVQMTLKKGADEEAGRMAPPSPRIPSKRAKVSSEQVVPDPSASVYPTPTPPVFIRKMRNAAVGTGCDIRLKVAVAGDPQPTLYWYHNDDLVNMDNQEYGGLWIRDCKPSDAGLYTCIATNHLGEARSSAVLAVLDLGEE--------------------NRTLYPNIWAVHSCEVFRSCRKQSYDSETTEDEA---AEPQIPLEAKEGARG-------FQDEAQRVPAGERMMDVAPDASNR--------WAASESTVLEREAL----------ALGSRAPGPQSARSPSDDVLRDSPP-------QVLPPPSPKFGRSTASPLLSRSGSGPATPLAPRKKVVVPTEYQDTVPGE-----FEEKIKQPKSSGMSQSSAQDSRPQTPVSEYSRKELTLRPSPKLTRASSKIFEKVRVFEERRRSIDNPEG-SISGRSWAGFNRASSIDSDEGGSRLGISRESSKEDLREALKADAAQRRTMFKQRAASLEDRPRYTQKVQDIENKFTEELQRIKKLVGKPHMKKSFSTEQLSTCHRSRQPVRKLEPIPPQVLQKLQDRERAQLAQLEQEMRERDQAKERSPPKSPSRRRKDHLAQQPPERAETKVVSTTGLEPSPPEAMSLSDLPGQRSPRFRGPSPSRDSTRRSPTVEISAMAEERPRGRAESPSRNVLEMTLRKVEPRPASPLVKRVVRVQEVPQANDQPMHRKTPIEVSLRKLERRPESPLVQGETVAIQDFPVQAPPKPPRVSSSSSSEEKMELEVTPPPPPLKLTIPKIIVEEEPMETDTPVEKTEKAVKVGTGKDEKHQRSRGRGRRQRPMSPELESSDDSYVSAGEDPLEAPVFEFPLQDTVASTGTEVLLKCIISGTPLPEVIWKKDNTEVKNSPTHVVKIEGERHSLLIKWTKPSDAGTYTVTAVNEVGEVSSSATLFIKPEPSQDHRGNLGVPMDVSSPITSDEEYLSPLEESMD---------FSSYRGPEPRKIVDTRFKEPPAFLAVIGDQSVIEGQEVTMSVLVTGQPKPMLYWLRDRVTIKTGTRHIVQETEEGNFEMIIKSAQRSDTGVYTCKIINEYGTKQCEGKLEVKARPVEPGLAIIRPVRDVMVKAGETALFECHVIGPQDTDVDWLSDGKLIQPALLNCKMHFDGKRCRLLLNSVHEDDSGTYTCKLSTAKEELTSSAKLKVIASIEPLFTRKLDVLEVIEGRNARFDCKVSGTPPPQVIWSHFDRPLEENEDIRILKEGGRHSLIISHVSNEDEGLYTVAARNSHGEDECAAELYVQEPRPAISSQIAKLEKMPSIPEEPEVPENEIERFTMPDFVKPLYDMDVVEGREAVLRCKVAGLPYPTITWFHNGKRIDSTEDRKMTQFRDVHSLVVRCVCHAHGGVYKCVISNKVGKATCYSHLYVTDILPDPPDGAPVVESITGKTITLSWKKPKRLDPSIDPSSLMYAIQQQALGSIQWTIIASCLKQTTYTISNLSKGVRYAFRVLSITSKAFSKPSPATEPMQLLDRGPYVQEAPVIIDKPDIVYMVEKQPLSITVTLNHVNASVTWK-RGGVTLSNRPGLFELSMPDDDQHTLKLCKVKSSDVGQLTCIANNKYGSDSCVLTLEMAVAPTFETIMEDLDVNVGETPRFAVVVEGKPVPDILWYKGDTLLSESSHFTFVYDDNECSLVVLNTQADDSGVYTCTAKNLAGSVSCKAELTVHTTKQYKD--DPMEDEASILRKMRRLTDYYDVHKEIGRGAFSYVKRVIQKAGKLEYAAKFISARAKRKASALRELNILSHLDHERILYFHDAFEKKNAVIIITELCHEELLDRLTKKSTILESEIRSSVRQLLEGINYLHQLDILHLDIKPDNILMADHSS--DQIRICDFGNAVKFMPDEAQYCKYGTPEFVAPEIVNQTPVSKATDIWPIGVLTYLCLTGVSPFAGENDRSSVLNIRNYNVAFEESMFTDLCHEAKGFVIKLLVADRLRPDANECLRHPWFKTLNKGKSISTESLKKFLSRRKWQRSLISYKSKMVMRSVPELLDDSSSHISIAVPRHLKKGSPPLSSSSDSDEDIDELPFIPMPLNVEFSGSRMSLTEIVGDDDMTGKLNGNAERPASLHPKSEPMEVEMSEREGGDPSARGRAKKRTTTEDEKGSSDEEPSQLAKRAELAKRPMRRGSSMESDEPEGGRRRGELRRGSSADSALQLHIKPEEG-TEESPTDGSRILQKSVSMELP-RRSPSPGAAKLSQE-----DYALKLELMRQRLLRGGSADNKMSGLRGPLLETLGMGDEKRFVRGSR-LGNPPLVRAASSESPRDDIP----KTKILRKSASFSQGDSEPMPLHRRIGAPLEIPLAQIEERRLQEAISMSALTEPVKDSRPITPKLQMPEEERHEKKKTEEKESVYKDNKPEEVIAVSKTEEEGRRVDQKSWDSDAQKKDQSKSEETREESEKVAEIEKKTSIVDETIEEEETRKDEEPEKETEPPTPKIEVKEYEGDVKVLPKSPEFIISTNSIMVTPTAAPASSPQSVSTYVTPSPPARTVLPDGRMSAYASIMQTIMVPSVPANTQS-DTVPIPTPTSTPPSVPVYAPISRHISEPTLSSTSSSKSDLHQTTEHPAVFSRVASTEHPPKEPSPPKTPTRASPKREPSPGSNIQDLASEEVFEARFKK-RESSLTRSLKRFSFQKTEDKPSTVSPETAEEMYRPGPTGAPLEFVPRRLEEKSKSVQDLREAEKDP--GFMRRLSMRLKRTPSVEKQEEKLKEEEASAPRRRLSWALGRRGSQEKKEIEMMRLDGGPEPPPEPESKAPSESPILAMRKKIGSTMASLSTRIRSHSEDRKD-----------------------------------------------DSEG---KMETKRTPIFNKLRRSTSEGGSLKRMGIPQNQLAAQSGQGTSSESLDSMSSIQSESAIKNAELDRRSRWDRWGLTRGKKDKTVSQPDIPASIARENGSLRSRQYTRLTSDFPPVFHIKLRDHVLLEGDPVTLSCLPAGSPHPHISWMKDKKPLEIDPRMNMISCPDGRQLLMIMKTTKKDAGLYECVAANPLATVTSSCVVSLARLPNSPGTPEVPQKYKNTALVVWRPSDTTAPCTYSLERKTEGENNWLIVATGVADCYYNVLDLPAGASYRFRVACVNKAGQGPYSSLSEVVVLDSTEPQKSSGTVVVKTLSSAPAPAVVTSTMTLPAMKPAAIKPAPSTNSAPSTVQPVKPAPPPASSTPTYRPVPDIRTPSPGTPTPAKAKSTLNITMAKPSPASPAAQPQPQPPPKPSPPVILPKPQTPVSVVSPPSQTPPVSPPPLVSPPPIIGKPISSVPMYVPATTTSTPVTPVTPVTPVTPVTPNTPSPALSPPVVLVTSLSPVGEGTGTPNRMTPSGRATPSGRITPSGRRTPIGKPGDSTLRQGVPQKPYTFMDEKARGRFGVIRECRENATGNLYMAKIVPYEPESKQTVLQEYDILKSLHHEKIMALHEAYVTPRYLVLISECCSGKELLHSLIDRFRYSEDDVVAYIVQILQGLDYLHSRRILHLDIKPENIIVTYMNVVKIIDFGSAQTFNPLFLKQFSPPIGTLDYMSPEMLKGDVVGPPADIWSIGILTYIMLSGRLPFTENDPAETEARIQAAKFDLSKLYQNVSQSASLFIKKILCSYPWARPTIKDCFTNSWLQDAYLMRLRRQTLTFTTTRLKEFLEQQQHIRAQEATKHKVLLRSYQSNPQTPSTPQ-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *. *. : .. .:.. . .***:* :: *** :*.*:**:* *.* *.*:* *:::.: : : . **:* * *.*:*:* * *. *.* .***:**:: : : ::*:: .. : :* : :* . * : . .:. : : **. :.. . * . . . * . .* .: . . .. . .. * *..* :* :. : : :*:: :*.*:*::::: ***: :. : . . * :.:: * :. . : ...* :* :*:*:*:**:::. . :: ::::** **:: ..: .: : * *.* : . . * . . .. . : . :.. * . .: . * .: . * . : . : : * *: * .* : : . . . : : *: * :. :. *: * :: ** :.*. :. ***: *:* :: : :.* . **:***. . * * . * : *::** * *** **:** : *. .:****. *:*:****:.***:***::*:**:.*.**:*** *******.*:** .:*.* * .* ***** *: :*.:*** *::***:** *** * *:* *: *.::::: : .* *** *::*..*.**** . * * **: .:*:***:***.* * ::************ .::** ::***::** *::* .:**:*.*:*:*****.*:*:***::*:*::**:***:**:* **. .* *.****.**:**:***:**:****: :* ****.* : ::**: : *:*: *: ** :*** ** *.:*:*.*** *** :.: * :. :: :.* **: : ***** : *: **** .:: :**:::* ..:**.::** **** ** ** :*:*:***:* .*: *. * : * *:: *****: *::.:*. *:* * *.*::*:. : * :* .* **:****::* *** :*****:*** ***:***. .**:**.*.:***::.*****:*.: .:* *******:****.*******:* ::: : *** :: * *:*:**:*:*********::*: .: .:*****. :** *:.* ** :*:.*:* :: **:***::. ::*:**** ****:*::::.*: *** :: :**:**** **** .::***:**:*:*: * :*:******** :. *.* **::* ***:*******:*:* *****:**:::*****:***.***** :::***********: * .*.:**:**:**:** ::*** * * * *****: ** .:.* * .*:**:** * * * .::*:*.:.*** ...:: :::**. .. ***...:*:::*** :* * *****:***:* . . :: .. : : *. : ** :******:*** * . : ::*:.*:*** :**.** :::*:: :** :*: :*****:**. : ::*********:** :. : :..* : .. . :. ::* :*: : ::*. *** ******* : : :. . * :. * . : .:. : * : . : . :. : *.. :* .* . * .: : .: * *:: . . ..*::: ** :***:**: ***.*: .*: :: ::*: . : : :***.*.*:***: *:*:****** . : :: *:*: : : *: :* * . :..* . **:**:*::: .: : *:: :* . :* * * . : **:*.: :*: *:* :::.:*.*** *: ::. : :* .* * : ... : *** ***::* ::*: * . .:: .******** *:*:*****:..** ****..* *:* *:***:.*. : : :* ****** * . *:.**:*** *:* *.::*:** :::* *. ..**: * * :*.** *:*.* .****::*:: :*:. * ::*:.**::* .** * : ****** *:***.*:*. *: * : . : * .. : *. ..: .. . .:. .:.. . . : . : . * *. . . ... .:.* : *. . *: :: :* .*. : * *:** * ..:* :***** *****:*::*********:* *******. ::***:** : *: :::**::*::*: *::*:*****:********:* *..:*:* .* *** ******. ::**:****:***. ::*******:*:::: *.:**:****** :** *: . ***::*:***::*: :*..:***. *:*:****** ** : ** ***:* .:** :** :.****: *::*:* :**.**:::**: :.**:*:** :**********.*****: :::: *: **:***:** * ..* ", "identical_positions": 1005, "similar_positions": 875, "identity": "26.77%" }, { "cls_id": "homologset.agr.HGNC:16902", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q00972-1", "uniprot_id": "BCKD_RAT", "id": "Q00972-1", "name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "aln": "--------MILTSVLGSG-----------PRSGSSLWPLLGSS-LSLRVRSTSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGS--HLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLD--DHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPD-------FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNA---PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVIT-IANNDVDLIIRISDRGGGIAH-------------------------------KDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHG-------------------FGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O55028-1", "uniprot_id": "BCKD_MOUSE", "id": "O55028-1", "name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "aln": "--------MILTSVLGSG-----------PRSWSSLWPLLGSS-LSLRARSTSATDTHHVELARERSKTVTSFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGS--HLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLD--DHKDVVTLLAEGLRESRKHIQDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPD-------FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNA---PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVIT-IANNDIDLIIRISDRGGGIAH-------------------------------KDLDRVMDYHFTTAEASTQDPRINPLFGHLDMHSGGQSGPMHG-------------------FGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14874-1", "uniprot_id": "BCKD_HUMAN", "id": "O14874-1", "name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "aln": "--------MILASVLRSG-----------PGGGLPLRPLLGPA-LALRARSTSATDTHHVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGS--HLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLD--DHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPD-------FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNA---PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVIT-IANNDVDLIIRISDRGGGIAH-------------------------------KDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHG-------------------FGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0R159-1", "uniprot_id": "B0R159_DANRE", "id": "B0R159-1", "name": "Protein-serine/threonine kinase", "aln": "--MRGRVTGQAMELLGSGGCRISVTRLFLSPSAKAAAPVTGAHGVGRRFRSTSSMSS-YSELARERSKTVTSFYNQSAIDASAEKPSVRLTPATMLYAGKSPDGQ--HILSSARYLHKELPVRIAHRIKGFRSLPFIIGCNPTILQVHELYIRAYHMLSDFPAIQDQETEARYSKMVKQLLD--DHKDVVTMLAEGFRECRKHILDEMLVRNFLDTTLTSRLGIRMLATHHIALHEDNPD-------FVGIICRRLSPKKIIEKWVDFARRLCEHQYGNS---PRVRINGHVAARFPFIPLPLDYILPELLKNAMRATMESHLDTPYNVPDVVVT-IANNDTDFVIRISDRGGGIPH-------------------------------SILDKVMHYHFSTAEQSAQDPRMSNLFDSMTN-SGPQSGPMHG-------------------FGFGLPTSRAYAEYLGGSLAIQSMQGIGTDVYLRLRHIDGKGESFRV---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P40530-1", "uniprot_id": "PDK1_YEAST", "id": "P40530-1", "name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial", "aln": "-------MWKIMRSWKCG----------------------GMR----WAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKE--EYMLTIKTINLLLSL-TCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLD--DHEDAIVVLAKGLQEIQSCYP-KFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDT--NKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQR-TPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEH---MPIEINL-LKPDDDELYLRIRDHGGGITP-------------------------------EVEALMFNYSYSTHTQQSADSESTDLP-------GEQINNVSG-------------------MGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK---", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53170-1", "uniprot_id": "PDK2_YEAST", "id": "P53170-1", "name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial", "aln": "MSKYQINCIRYRHFLRTSN---------ISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * . : . : . * . . : : : :: * : .:::: :: **: * : :. . * . . : . . .: . ::*: : : :: .:. . : :*. * *: :::. .:::: : . .:* : . : : . : . : : . * . * :* *.*:: *:::*: .* : * : : :* . :** *:.**: . : : . .: :. . : * :*:**. .:.* * .*.: ::*: * **** ::* : ", "identical_positions": 41, "similar_positions": 116, "identity": "8.2%" }, { "cls_id": "homologset.agr.HGNC:16903", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LDY6-1", "uniprot_id": "A0ABK0LDY6_RAT", "id": "A0ABK0LDY6-1", "name": "TNFAIP3-interacting protein 1", "aln": "MEGRGPYRIYDPGGSTPLGEEVSAAFDRLVEENTRLKGKIQGIKMLGELLEESQMEASRLRQKAEALVRDSELPPPPPAPSLVSFDPLAELTGQDTKVQAHPTTTTTTTTTTTTTTIGNSMEKSVSASKPPSNGASSDFEVVPPEEQSSPETGHHSRNVMELGSPPPEDGNLMLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKSLEQRDQAAERLREENTELKRLLMNSNCKEGLCGQPSSPKTEGAGKKGVAGQQQASMTASKVPEAGAFGTAEKKVKLLEQQRMELLEVNKQWDQHFRTMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTTEAKELRQKVKYLQDQLSPLMRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTTAQLRTLKEEEKAKEALKQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRN--QNSQVMDPPPDRPAEPEPADLRLPKV-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WUU8-1", "uniprot_id": "TNIP1_MOUSE", "id": "Q9WUU8-1", "name": "TNFAIP3-interacting protein 1", "aln": "MEGRGPYRIYDPGGSTPLG-EVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATT-GNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWDQHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRN--QSSQVMDPPPDRPAEPESADNDCDGPQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15025-1", "uniprot_id": "TNIP1_HUMAN", "id": "Q15025-1", "name": "TNFAIP3-interacting protein 1", "aln": "MEGRGPYRIYDPGGSVPSG-EASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLRQKAEELVKDNELLPP-PSPSLGSFDPLAELTGKDSNVTASPTAPACPS------------DKPAPVQKPPSSGTSSEFEVVTPEEQNSPESSSHAN-AMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKASGERYHVEPHPEHLCGAYPYAYPPMPAMVPHHGFEDWSQIRYPPPPMAMEHPPPLPNSRLFHLPEYTWRLPCGGVRNPNQSSQVMDPPTARPTEPESPKNDREGPQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***************.* * *.****:***:**:*** *:*****************:******* **:*.** ** .:*** *** ******:*::* . *::.: .: :*. ...*.**.*:**:****..***.***:. *. * **. * **.** *******************.**************************************:***********.***** ********* ***:***... *** .*:*.*** **:***.********: *.****. *:*:******:***** **************:****************.*******:**********************************:*********:********* ************************:.*****:*******.*. ******************************************************:.***:::*:****:***:**************:******:******************.::***********:.****** ************** **.*:** *.*******. **:***... ", "identical_positions": 508, "similar_positions": 89, "identity": "78.03%" }, { "cls_id": "homologset.agr.HGNC:16904", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P12020-1", "uniprot_id": "CRIS1_RAT", "id": "P12020-1", "name": "Cysteine-rich secretory protein 1", "aln": "MALMLVLLFLAAVLPPSLLQDTTDEWDRDLENLSTTKLSVQEEIINKHNQLRRTVS-------PSGSDLLRVEWDHDAYVNAQKWANRCIYNHSPLQHRTTTLKCGENLFMANYPA-------SWSSVIQDWYDESLDFVFGFGPKKVGVKVGHYTQVVWNSTFLVACGVAECPDQ-PLKYFYVCHYCPGGNYVGRLYSPYTEGEPCDS----CPGNCEDGLCTN-----------SCEYEDNYSN-CGDLKKMVSCDDPLLKEGCRASCFCEDKIH-----------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q03401-1", "uniprot_id": "CRIS1_MOUSE", "id": "Q03401-1", "name": "Cysteine-rich secretory protein 1", "aln": "MALMLVLFFLAAVLPPSLLQDSSQENR--LEKLSTTKMSVQEEIVSKHNQLRRMVS-------PSGSDLLKMEWNYDAQVNAQQWADKCTFSHSPIELRTTNLRCGENLFMSSYLA-------SWSSAIQGWYNEYKDLTYDVGPKQPDSVVGHYTQVVWNSTFQVACGVAECPKN-PLRYYYVCHYCPVGNYQGRLYTPYTAGEPCAS----CPDHCEDGLCTN-----------SCGHEDKYTN-CKYLKKMLSCEHELLKKGCKATCLCEGKIH-----------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P54108-1", "uniprot_id": "CRIS3_HUMAN", "id": "P54108-1", "name": "Cysteine-rich secretory protein 3", "aln": "MTLFPVLLFLVAGLLPSFPAN--EDKDPAFTALLTTQTQVQREIVNKHNELRRAVS-------PPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASS-------SWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCAS----CPDNCDDGLCTN-----------GCKYEDLYSN-CKSLKLTLTCKHQLVRDSCKASCNCSNSIY-----------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VFY2-1", "uniprot_id": "Q9VFY2_DROME", "id": "Q9VFY2-1", "name": "SCP domain-containing protein", "aln": "-MMQPSAVLLTTIMIISCEVAFACNGKIIASGITAEER---SIILQEHNRLRQIVATGRYPGQPGAENMREIVWDDELAARAQKWADNCQFRHDPHR-TINRFTMGQNLAIIWSTAPLDADDGDFPSRIQSWFNEVQKYSFGDAWSP---KTGHYSQLVWGETSLVGCGYAEYKDTSKYNKLYVCNYGPGGNVVG--YNPYEVGKPSCSTYGMKPSSRYQGLCAAPGSSPAANSVYGANTIETYEYGYNSSPSSQTANNNPPTNNINKSQFSYNQPRPKPVQTINPNPSPFNPQAAVPSASTFGGSSFGSASRGGSHAYTTDPSQSAGRYKHKLEAYRPSAAEFEKSVHKHTILRTYIEQNQQRQDQQQQQQQKEQDQQQQQPEPSSTKKPSRGWSLLTWRG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .:*.: : * : : : : *:.:**.**: *: * . :: .: *: : ..**:**:.* : *. . . : *:** : : .:.. **.*::* . :. . . .***:*:** .: *.** * . . ***:* * ** . * ** * *. * *. :***: .. : * :... .. . : . .. ", "identical_positions": 51, "similar_positions": 76, "identity": "12.69%" }, { "cls_id": "homologset.agr.HGNC:16905", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ER30-1", "uniprot_id": "KLH41_RAT", "id": "Q9ER30-1", "name": "Kelch-like protein 41", "aln": "MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEK---KKEMALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKSAEKGGTGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSIVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVSSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AUC9-1", "uniprot_id": "KLH41_MOUSE", "id": "A2AUC9-1", "name": "Kelch-like protein 41", "aln": "MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEK---KKEVALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60662-1", "uniprot_id": "KLH41_HUMAN", "id": "O60662-1", "name": "Kelch-like protein 41", "aln": "MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAK---KKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QEG2-1", "uniprot_id": "KL41B_DANRE", "id": "F1QEG2-1", "name": "Kelch-like protein 41b", "aln": "MDP-KAIKEELRLFQSTLLQDGLKELLNENKFVDCTLKIGDRCFPCHRLIMAACSPYFRELFFSEDGKEK-DIGKEVVLDDVDPNIMDMILQYLYSAEIDLVDDNVQEIFAVANRFQIPSVFTVCVNYLQQKLSMANCLAVFRLGLVLSVPRLAIAARDFIADRFETVSSEEEFLQLAPHELLALIGGDMLNVEKEEVVFESVMKWVRNDKANRVKSLAEAFDCIRFRLLPEKYFREKVETDDIIKGDPELLKKLQLVKDAFKGKLPE-KKPKEKK-EGEVNGEEEGEEMLPGFLNDNRRLGMYGRDLIVMINDTAAVAYDVVENECFLAAMAEQVPKNHVSLCTKKNQLFIVGGLFVDEESKESPLQCYFYQLDSFSSDWRALPPMPSPRCLFNLGESENLLFAIAGKDLQTNESLDSVMCFDTERMKWSETKKLPLHIHGHSVVSHNNLVYCIGGKTDDNKALSKMFVYNHKQSEWRELASMKTPRAMFGAVVHKGKIIVTGGVNEDGLTALSETYDFDTNKWDTFTEFPQERSSVNLVSSGGNLFSIGGFAIVELEDKNIGPSEITDIWQYEEDKKTWSGMLREMRYASGSSCVGMRLNAARMPKL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E9QIN8-1", "uniprot_id": "KL41A_DANRE", "id": "E9QIN8-1", "name": "Kelch-like protein 41a", "aln": "MEP-MSVKEDLRLFQSTLLQDGLKELLKENKFVDCILKVGDRSLPCHRLIMAACSPYFRELYFTEDGTEKKDANKEVVLENVDPNIMDMIVNYLYSADIDITDDNVQDVFAVANKFQIPSVFTVCVNYLQNKLSLGNCLAIFRMGLVLNCPRLAVSARDFIAEHFETLSKDEEFLEFNAPEFFAIIGCDALNVEKEELVFELLMKWVRKNKENRAKALGDAFEHIRFRLLPEKYLKEKVEKDDIIKADPELIKKLKVIKDAFAGKLPQ-IKEGEK--------EGEGENELPGFLNDSQRLGMFNRDLILMINDTAAVAYDANENECFLAAMAEQIPRNHVSITSKKNLLYVAGGLFVDEENKDSPLQCYFYQMDPHSPNWIALPPMPSPRCLFAMGEFENLLFAVAGKDLQSNESLDSVLCYDVDKMKWLETKKLPLRIHGHSVISQNGLVYCIGGKTDENKTINKMFAYNHKKSEWKELAAMKTPRSMFGATVHKGKIVVVGGVNEDGLLSSCEAYDFGTNKWEVFAEFAQERSSVNVLSVDGVLYAVAGFTIKENEDKQCVPSEITDIWQYEEDKKQWSGMIGEMRYASGASCVSMRLNVAKMPKL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:. : *:***:**********:**.*:**:** ** **:.:******::******** :::* * **:.*::*** *:*:*::*****.**: *.***::**::.:***********.***::*: .****::*:**:*. ****::**:*::::* :..:*:*::: . *::::*. * ******* *** :*****.:* **.* *.:.*: *****:.***::::**.*****.:*:: **::::**** ****: * * : .*: ***:*** * **: :***:::********* ****:*:*:***:*:** *: :::* :::.***:****.*:.***.**:*:* :.:* .***:**.**** :** :: ::.:******:: *****:*:* ** *.*:**::::**.*:*::.::**:*****::* .::* :* *:.:*::**.** **:***..:*****::.***.**** : *::*: ****:.::**.*****:.::* * *:::.**:: : *.*: *:*:.***:**:*** *:**: *:*****:**:. *** ::.**", "identical_positions": 314, "similar_positions": 205, "identity": "51.56%" }, { "cls_id": "homologset.agr.HGNC:16906", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P24473-1", "uniprot_id": "GSTK1_RAT", "id": "P24473-1", "name": "Glutathione S-transferase kappa 1", "aln": "MGPAPRVLELFYDVLSPYSWLGFEVLCRYQHLWNIKLKLRPALLAGIMKDSGNQPPAMVPHKGQYILKEIPLLKQLFQVPMSVPKDFFGEHVKKGTVNAMRFLTAVSMEQPE---MLEKVSRELWMRIWSRDEDITESQNILSAAEKAGMATAQAQHLLNKISTELVKSKLRETTGAACKYGAFGLPTTVAHVDGKTYMLFGSDRMELLAYLLGEKWMGPVPPTLNARL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DCM2-1", "uniprot_id": "GSTK1_MOUSE", "id": "Q9DCM2-1", "name": "Glutathione S-transferase kappa 1", "aln": "MGPAPRILELFYDVLSPYSWLGFEVLCRYQHLWNIKLQLRPTLIAGIMKDSGNQPPAMVPRKGQYIFKEIPLLKQFFQVPLNIPKDFFGETVKKGSINAMRFLTTVSMEQPE---MLEKVSREIWMRVWSRDEDITEYQSILAAAVKAGMSTAQAQHFLEKISTQQVKNKLIENTDAACKYGAFGLPTTVAHVDGKTYMLFGSDRLELLAYLLGEKWMGPVPPTANARL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2Q3-1", "uniprot_id": "GSTK1_HUMAN", "id": "Q9Y2Q3-1", "name": "Glutathione S-transferase kappa 1", "aln": "MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPE---MLEKASRELWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A3X2-1", "uniprot_id": "A0AB13A3X2_DANRE", "id": "A0AB13A3X2-1", "name": "Glutathione S-transferase kappa", "aln": "MSSSRKVVELFYDVVSPYSWLAFEVLCRYKNVWNIDLKFKPSFLGGVFHGSGNTEPGMVDNKLHYMITDLKLMSEYYGVPVNPPS-----PCKKDTLPAMRFVTAIAEKNQEENVLVEKVSRELWKRMWQKHQDITQPLSLTEAGLLVGLSSNEVEELLTNAKSQPIKDKLKSVTQEALEKNAFGLPFIVCHVNGKVEVFFGCDRFELIAHCIGEKWAGPCPIKTTM--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PDP8-1", "uniprot_id": "A0A8M9PDP8_DANRE", "id": "A0A8M9PDP8-1", "name": "Glutathione S-transferase kappa", "aln": "MISSGKVIKLFYDISSPYSWLAFEVLCRYKNIWNVELKLKPAYLAGVMYGSGNQPPVLNPSKLLYMTSDLTLLSQYFGVPMYRPSK----LIKKDSVIPMRFVTAVAEKEKDGDDLVEKVSRELWKRMWSTHQDIVQPASLTEVGIKAGFSANEVDDILILAKSQQIKDRLTSITNEALKYKCFGLPFIVVQVDGKAGVFFGSDRFELMAYFLGEKWFGPHPT------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . : ::****: ******.**:****:::**:.*:::*: : *:: .*** * : * *: .:: *: . :*: *. :*.:: .***:*:: :. : ::**.***:* *:*. .:**.: .: .. .*::: :.: :* : :*.:* . * * . .**** * :*:*:. ::**.**:**:*: :**** ** * ", "identical_positions": 73, "similar_positions": 81, "identity": "31.88%" }, { "cls_id": "homologset.agr.HGNC:16909", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K254-1", "uniprot_id": "A0A0G2K254_RAT", "id": "A0A0G2K254-1", "name": "Kinetochore protein NDC80", "aln": "------MKRSSVSSCGAGRLSMQELRSLDLNKPGLHTPQT-ERSTFGKLSTHKP------------TSERKVSIFGKRTS--------EHGSRN-------SQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLYEFLTEN----GYVYSVSMKSLQAP------STKDFLKIFAFLYGFLCPSYELPDTKCEEEVPRIFKELGYPFALSKS-SMYTVGAPHTWPHIVAALVWLTDC---IKIHDAMKQSS-----------PLFDDGQAWGEETEDG-----IKHNKLFLDYTKKCYEKFMTGADTFEDVDAELQAKLKDLYKVDASKLESLVEENKALNEQIARLEQEREKEPNRLISLRKLKAS-LQADVQNYKAYMSNLESHSSILEQKLSSLDEEIGRLELECETVKQENTRLQSVVDNQKYSIADIERINHEKNELQQTINKLTKDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLK--------------LIPKGAENSKGYDFEIKFNPEAGAN------CLVKYRTQVYAPLKELLNEIEEEINKALNKKMGLEDTLEQLNTVKTESKRAVRMLKEEVQKLDDLYQQKVKEAEEEDKKCASELDSLEKHKHLLESAVNEGLSEAMGELDAVQREYQLAVQTTTEERRKVGNNLQRLLEMVATHVGSLEKHLEEQIVKADREYEECTSEDLLEN-IRRIAEKYKSNAAQLKAPDK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D0F1-1", "uniprot_id": "NDC80_MOUSE", "id": "Q9D0F1-1", "name": "Kinetochore protein NDC80 homolog", "aln": "------MKRSSVSTCGAGRLSMQELRTLDLNKPGLYTPQTKERSTFGKLSTHKP------------TSERKVSIFGKRTS--------GHGSRN-------SQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLYEFLTEN----GYVYSVSMKSLQAP------STKEFLKIFAFLYGFLCPSYELPGTKCEEEVPRIFKALGYPFTLSKS-SMYTVGAPHTWPHIVAALVWLIDC---IKIDTAMKESS-----------PLFDDGQLWGEETEDG-----IKHNKLFLEYTKKCYEKFMTGADSFEEEDAELQAKLKDLYKVDASKLESLEAENKALNEQIARLEEEREREPNRLMSLKKLKAS-LQADVQNYKAYMSNLESHLAVLKQKSNSLDEEIGRVEQECETVKQENTRLQSIVDNQKYSVADIERINHEKNELQQTINKLTKDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLK--------------LIPKGAENSKGYDFEIKFNPEAGAN------CLVKYRTQVYAPLKELLNESEEEINKALNKKRHLEDTLEQLNTMKTESKNTVRMLKEEIQKLDDLHQQAVKEAEEKDKKSASELESLEKHKHLLESGVNDGLSEAMDELDAVQREYQLTVKTTTEERRKVENNLQRLLEMVATHVGSLEKHLEEENAKADREYEEFMSEDLLEN-IREMAEKYKRNAAQLKAPDK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14777-1", "uniprot_id": "NDC80_HUMAN", "id": "O14777-1", "name": "Kinetochore protein NDC80 homolog", "aln": "------MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKP------------TSERKVSLFGKRTS--------GHGSRN-------SQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTEN----GYAHNVSMKSLQAP------SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKS-SMYTVGAPHTWPHIVAALVWLIDC---IKIHTAMKESS-----------PLFDDGQPWGEETEDG-----IMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKAS-LQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLK--------------LIPKGAENSKGYDFEIKFNPEAGAN------CLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSEN-IKEIRDKYEKKATLIKSSEE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DRJ7-1", "uniprot_id": "NDC80_DANRE", "id": "Q6DRJ7-1", "name": "Kinetochore protein NDC80 homolog", "aln": "------MSRRPSS-----RYSEMPMRVTDSRMSLINATPQNKDNAFGKLNIPKPQS---------TTSERRTSFFGKGIG--------AGGQRN-------SMFGSYGGSEKMKDPRALHDKAFVQQCIKQLYEFLVDR----GFPGSITVKALQSP------STKEFLKIYEFIYNFLEPSFQMPTAKVEEEIPRMLKDLGYPFALSKS-SMYSIGAPHTWPLALGALIWLMDA---VKLFGGQREQD-----------LLFSDFSDELCDLEDR-----TEYNKLIMEYCSDTYNKFMQGADTFDDEDDDFLYKLKKLYNVDEALLHSQQEKHSMLMEHVERLE--RESQTDRLVGKRTEKLR-LQTDLQKLQNYRCTLEAHKTGLENKSAGLTEELEAVEMQLEGLKQERTRLQHILENQKFTPADIERINRERNELQQTIHGLSQSLEEGEQLVWNEEVNLSKTKEKAELKVAEYNKLGRKLK--------------LIPLSAENACGHDFEIR--ADYSAT------TITQYKTQIQNPLKNMMVEVEEEFSRLSNVNLSLEETVEQVKSNIFDKENDIKQLKEQIRKVDQQLENAMQEMALEDDKWAAELDSAETHKKLFEKNVMQGIEEAEEEVKAAQQQYHVVVQETNEKNRMVVKNMTDLFSSTVNHLFAVEKHCDEQLKRFDKLKDIVREDEADINQLTDLVENFIKKANSL-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P40460-1", "uniprot_id": "NDC80_YEAST", "id": "P40460-1", "name": "Kinetochore protein NDC80", "aln": "MQSSTSTDQHVLHHMDPHRFTSQIPTATSSQLRRRNSTNQGLTDMINKSIARNTISGTGIPTGGINKNKRTRSTVAGGTNGTALALNDKSNSRNSVSRLSINQLGSLQQHLSNRDPRPLRDKNFQSAIQEEIYDYLKKNKFDIETNHPISIKFLKQP------TQKGFIIIFKWLYLRLDPGYGFTKS-IENEIYQILKNLRYPFLESINKSQISAVGGSNWHKFLGMLHWMVRTN--IKLDMCLNKVDRSLINQNTQEITILSQPLKTLDEQDQRQERYELMVEKLLIDYFTESYKSFLKLEDNYEPSMQELKLGFEKFVHIINTDIANLQTQNDNLYEKYQEVM----KISQKIKTTREKWKA-LKSDSNKYENYVNAMKQKSQEWPGKLEKMKSECELKEEEIKALQSNISELHKILRKKGISTEQFELQNQEREKLTRELDKINIQSDKLTSSIKSRKLEAEGIFKSLLDTLRQYDSSIQNLTRSRSQLGHNVNDSSLKINISENLLDRDFHEGISYEQLFP------KGSGINESIKKSILKLNDEIQERIKTIEKDNITLEKDIKNLKHDINEKTQINEKLELELSEANSKFELSKQENERLLVAQRIEIEKMEKKINDSNLLMKTKISDAEELVTSTELKLEELKVDLNRKRYKLHQQVIHVIDITSKFKINIQSSLENSENELGNVIEELRN-------LEFETEHNVTN---------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VYB1-1", "uniprot_id": "Q9VYB1_DROME", "id": "Q9VYB1-1", "name": "Kinetochore protein NDC80", "aln": "------MSHLMPRRTSEFRGDVLEERGTADKRQTRATKRSAATHTPSSSQAAPRRP----------SASRLPQPLNLERD--------RASQMG----VTPKRGHRFVPSTAERAIAPHSDKKWVAERAQQILEYLHGIQ-NSEAPTGLIADLFSRPGGLRHMTIKQFVSILNFMFHHIWRNRVTVGQNHVEDITSAMQKLQYPYQVNKS-WLVSPTTQHSFGHVIVLLDFLMDFLPPLPSSDVVEEEFPFMETMEQPSSYLNSMHCESTTIMSTTQAHAIQLDEDVNGLLFEEASKCIALWDQELTNEEAKLQAETRDQVISKKCDLPDRKALDQLIGDLKTKLQQLENKLHDPSEDNKLNKLERLTKEHDQLAQQLAASEEELIKKLKLYEQLSAQVEEKQSNLRQQMKYEKRLEQAVNRQKFSAQQLKELQMKCDDMENYSKAYERQVKEVSELELHQQVMLSRAKQKQLDSVEVFNSHVRHLSMDPVICG-------LIKSGIGQQSDLTLPLNPNQEDISERVQCLELLGKLLQQHRQQNIDRRQMLDKQVAKVKSDSIELDTEIATMDSQLRAQKQRLTKMEASYRTKRDMQAQHRQQLLEDQYDQTARLDELEKREKQALEKLEASKQRNEDLLTAAEQFQEQDLKARQDR----LEKCEQKLAKAEDQLLAVESKVNATQAKLNEVEQKVYSAKLPS--FQPVLDAIKNH---------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: * . : .. . .* . . . .. . . : . ** : .:: ::* : . :. * : * *: * ::: : . ::: :: * **: . . : .: : * :: : .: : . . :.: . : : : .: .. : . . : : .: : : * : :: : . : : : : . . ..*. : .: : ::: : : :.: . . . . . .:: : : :.. ::*. * : . : : . . ::.. . . *: : :. . . :: . . :: .::. *.: : : . : :.: . . :: : . ::. : . .. : . : : : ", "identical_positions": 19, "similar_positions": 171, "identity": "2.61%" }, { "cls_id": "homologset.agr.HGNC:1691", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q61003-1", "uniprot_id": "CD6_MOUSE", "id": "Q61003-1", "name": "T-cell differentiation antigen CD6", "aln": "------------MWLFL-----GIAG-----------------LLTAVLSGLPSPAPSGQHKNGTIPNMTLDLEERLGIRLVNGSSRCSGSVKVLLES-WEPVCAAHWNRAATEAVCKALNCGDSGKVTYLMPPTSELPPGATSGNTSSAGNTTWARAPTERCRGANWQFCKVQDQECSSDRRLVWVTCAENQAVRLVDGSSRCAGRVEMLEHGEWGTVCDDTWDLQDAHVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGIDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCRSLGCGSAVARPRGLPHSLDGRMYYSCKGQEPALSTCSWRFNNSNLCSQSRAARVVCSGSQRHLNLSTSEVPSRVP-VTIESSVPVSVKDKDSQGLTLLILCIVLGILLLVSTIFIVILLLRAKGQYALPASVNHQQLSTANQAGINNYHPVPITIAKEAPMLFIQPRVP--ADSDSSSDSDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFQMPPLEEGLEELHVSHIPAADPRPCVADVPSRGSQYHVRNNSDSSTSSEEGYCNDPSSKPPPWNSQAFYSEKSPLTEQPPNLELAGSPAVFS-GPSADDSSSTSSGEWYQNFQPPPQHPPAEQFECPGPPGPQTDSIDDDEEDYDDIGAA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V8U0-1", "uniprot_id": "G3V8U0_RAT", "id": "G3V8U0-1", "name": "T-cell differentiation antigen CD6", "aln": "MLPVWHQQWICITWLSLSDLYDGMANNTPRCAAESKWIAVCKDLEQVLRQSLPPPAPSDQHRNGSIPNMSSDPEEQLGIRLVNGSSRCSGFVQVLLES-WEPVCAGHWNRAATEAACNALGCGDLGNFTHLAPPTSERPPGATSRNTSSSRNTTWAGAPTVRCHGANWQLCKVEDYECSSDRRLVWVTCAENQAVRLVDGGSRCAGRVEMLQHGEWGTVCDDTWDLDDANVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGVDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCQSLGCGSEVDRPKGLPHSLAGRMYYSCKGEELTLSTCSWRFNNSNLCSQSLAARVVCSGSQRHPNLSTSEVPSRVP-VTIESSVPVSVKDKDSQNLTLLIPCIVLGILLLVSLIFIVFLLLKAKGQYALPTSVNHQQLSTANPAGINNYHPVPITIAKEAPMLFIKPRVP--EDSDSSSESDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFRMPPLEEGLEELHVSNIPAADPRPCVVDAPSLGSQYHTRNNSDSSTSSEEGYCNDPSSKPPPWNSQVFS-EKSPLTEQPPNLELAGSQAMFS-GASADDSSSTSSGEWYQNFQPPPQHPPVEQFECPGPPDLQADSIDDDEEDYDDIGAA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P30203-1", "uniprot_id": "CD6_HUMAN", "id": "P30203-1", "name": "T-cell differentiation antigen CD6", "aln": "------------MWLFF-----GITG-----------------LLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIAFILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTANPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPPNLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDND--DYDDISAA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** : *::. * . .. *.***..* ...: . : *:* :**.**** *** *:* **: ***.*.. *: *:**.*.**.**. : * ***.* ** .:: *** : *:* * **: * **:*::*:* : * ** * . ******:*:*****.. ********:*****:********:**:***:** *****:**.*******:************:********* **::*********.************* * *******:*****.****************:*****: * **:****** *******:*:* :**.************** ****:**.*: ****.***: * *******.*.:::*:*: * *** .******** * ***.::**: **:****. ****:*.*: ** *.*:******.**. ** *: :.* ****.*:*********:******************:**.**.**:************.*:**:*:* *:.* ** *.*** *.**:***** *.***.*.** ****.*.* *:*.: **********: . ** *..********************* *. *** ***.*. *.** *:* *****.**", "identical_positions": 440, "similar_positions": 132, "identity": "62.5%" }, { "cls_id": "homologset.agr.HGNC:16910", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WVJ3-1", "uniprot_id": "CBPQ_MOUSE", "id": "Q9WVJ3-1", "name": "Carboxypeptidase Q", "aln": "MRSLFFLFI--VHLLALGSGKAVFKNGVSQRTFREIKEEIANYEDVAKAIINLAVYGKYQNRSYERLGLLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLENVHLEQVRIPHWERGEESAVMLEPRIHKMAILGLGSSIGTPPGGITAEVLVVASFDELQRRASEARGKIIVYNQPYTGYEKTVQYRVQGAVEAAKVGAVASLIQSVASFSIYSPHTGIQKYQDGVPKIPTACITVEDAEMMSRMASRGNKIVIHLEMGAKTYPDTDSFNTVAEITGSMYPEEVVLVSGHLDSWDVGQGALDDGGGAFISWEALSLVKDLGLRPKRTLRLVLWTAEEQGGIGASQYYELHKANISKYSLVMEADSGTFLPTGLQFTGSDKARAIMKEVMNLLQPLNVTKVFSNGEGTDINFWIQAGVPGASLRDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVAYVVADMDEMLPRS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6IRK9-1", "uniprot_id": "CBPQ_RAT", "id": "Q6IRK9-1", "name": "Carboxypeptidase Q", "aln": "MRFLFFLFVAVVHLFSLGSGKAIYKSGVSQRTFQEIKEEIANYEDVAKAIINLAVYGKYQNRSYERLGLLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLENVHLEQVRIPHWERGEESAVMVVPRIHKLAILGLGGSIGTPPEGITAEVLVVASFVELQRRASEARGKIVVYNQPYTDYGKTVQYRERGAVEAAKVGAVASLIRSVASFSIYSPHTGHQGYQDGVPKIPTACITIEDAEMMSRMASRGDKIVIHLKMGAKTYPDTDSFNTVAEITGSKYPEEVVLVSGHLDSWDVGQGALDDGGGAFISWEALSLVKDLGLRPKRTLRLVLWTAEEQGGVGASQYYELHKANISKYSLVMEADSGTFLPTGLQFTGSDKARAIMKEVMSLLQPLNITKVFNDAEGTDINFWIQAGVPGASLRDDLYKYFFFHHSHGDTMTAMDPKQMNVAAAVWAVVAYVVADMEEMLPRS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y646-1", "uniprot_id": "CBPQ_HUMAN", "id": "Q9Y646-1", "name": "Carboxypeptidase Q", "aln": "MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQNRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESAVMLEPRIHKIAILGLGSSIGTPPEGITAEVLVVTSFDELQRRASEARGKIVVYNQPYINYSRTVQYRTQGAVEAAKVGALASLIRSVASFSIYSPHTGIQEYQDGVPKIPTACITVEDAEMMSRMASHGIKIVIQLKMGAKTYPDTDSFNTVAEITGSKYPEQVVLVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTAEEQGGVGAFQYYQLHKVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGASLLDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVSYVVADMEEMLPRS", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: *:* *. ***::* ****: *.*:*:***.*******. ************** ********.*********************************:**** ***************: *****:******.****** *********:** *************:****** .* :***** :**********:****:************* * **************:***********:* ****:*:********************* ***:*****************:***************:***********************:** ***:***.***:******:*:*************:******:***.******:*:*:...****************** ******************.****************:******:******", "identical_positions": 402, "similar_positions": 48, "identity": "85.17%" }, { "cls_id": "homologset.agr.HGNC:16912", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZDS4-1", "uniprot_id": "D3ZDS4_RAT", "id": "D3ZDS4-1", "name": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase", "aln": "MAATSGGFQPRERRFSVQEQDWDPAPPKRPRLGAGSKCGGRRLIVVLEGASLETVKVG------KTYELLNCDKHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPS--------SDPVVFVVGAFAHG--KVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35130-1", "uniprot_id": "NEP1_MOUSE", "id": "O35130-1", "name": "Ribosomal RNA small subunit methyltransferase NEP1", "aln": "MSAASGGFQPRERRFSVQEQDWETTPPKKLRLGAGSKCGGRRLIVVLEGASLETVKVG------KTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPS--------SDPVVFVVGAFAHG--KVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92979-1", "uniprot_id": "NEP1_HUMAN", "id": "Q92979-1", "name": "Ribosomal RNA small subunit methyltransferase NEP1", "aln": "MAAPSDGFKPRERSGGEQAQDWDALPPKRPRLGAGNKIGGRRLIVVLEGASLETVKVG------KTYELLNCDKHKSILLKNGRDPGEARPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSIPVVSDVRELVPS--------SDPIVFVVGAFAHG--KVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWGVI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W4J5-1", "uniprot_id": "NEP1_DROME", "id": "Q9W4J5-1", "name": "Ribosomal RNA small subunit methyltransferase NEP1", "aln": "MGGQGKAINRKRKFVGRKADDPEFDLDKKQFKVLHLNATEKRLIIVLEGAQLETVKVH------NTFELLNCDDHAGIMRKNQRDPGSCRPDITHQCLLMLFDSPLNRAGLLQVFVRTEHNVLIEINPQTRIPRTFKRFAGLMVQLLHKFQIRANDSSRRLMSVIKNPITDHVPVGCKKYAMSFSGKLLPNCRDLVPHGDETSASYDEPVVIVIGAFAHG--VLKTDYTEELFSISNYPLSAAIACSKICSAFEEVWGVV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06287-1", "uniprot_id": "NEP1_YEAST", "id": "Q06287-1", "name": "Ribosomal RNA small subunit methyltransferase NEP1", "aln": "MVEDSR-VRDALKGGDQKALPASLVPQAPPVLTSKDKIT-KRMIVVLAMASLETHKISSNGPGGDKYVLLNCDDHQGLLKKMGRDISEARPDITHQCLLTLLDSPINKAGKLQVYIQTSRGILIEVNPTVRIPRTFKRFSGLMVQLLHKLSIRSVNSEEKLLKVIKNPITDHLPTKCRKVTLSFDAPVIR-VQDYIEKLDD-----DESICVFVGAMARGKDNFADEYVDEKVGLSNYPLSASVACSKFCHGAEDAWNIL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . .. : . : . : :*:*:** *.*** *: ..: ***** * .:: * ** .. *******.** *:***:*:** ***:::*.:.:***:** .******.**.*********:.:*: :. .:*:.*****::**.*. * * **. : :: : .:.: ..:**:*:* . :*.:: ..:*******:::*:*. . *:.*.::", "identical_positions": 91, "similar_positions": 83, "identity": "35.0%" }, { "cls_id": "homologset.agr.HGNC:16913", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9NSA3-1", "uniprot_id": "CNBP1_HUMAN", "id": "Q9NSA3-1", "name": "Beta-catenin-interacting protein 1", "aln": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q4KM58-1", "uniprot_id": "Q4KM58_RAT", "id": "Q4KM58-1", "name": "Beta-catenin-interacting protein 1", "aln": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JJN6-1", "uniprot_id": "CNBP1_MOUSE", "id": "Q9JJN6-1", "name": "Beta-catenin-interacting protein 1", "aln": "MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ", "tax_id": 10090, "tax_name": "Mouse" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "************************************************.******* ************************", "identical_positions": 79, "similar_positions": 1, "identity": "97.53%" }, { "cls_id": "homologset.agr.HGNC:16914", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O75325-1", "uniprot_id": "LRRN2_HUMAN", "id": "O75325-1", "name": "Leucine-rich repeat neuronal protein 2", "aln": "-----MRLLVAP-----------LLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYT------------PRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAID-SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN-ATGTR-VRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAG----LRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYT-----CVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA--FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLG-------TGQPRKGVGGRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLP---RSSEGE---------TLLPP------------------------LSQNS-------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZAV8-1", "uniprot_id": "D3ZAV8_RAT", "id": "D3ZAV8-1", "name": "", "aln": "-----MRLLVAA-----------LLLSWAASTNTAVPVVPWRVPCPPQCACQIRPWYT------------PRSSYREATTVDCNDLFLTAVPPGLPAGTQTLLLQSNSISRIEQTELGYLANLTELDLSQNSFSDARDCDFQALPQLLSLHLEENQLSRLEDHSFAGLTRLQELYLNHNQLCRISPRAFEGLGNLLRLHLNSNLLRTID-SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN-ATGTH-VRFIEPQSTLCAEPPDLQRRPVREVPFREMTDHCLPLISPRSFPSSLQVASGESLVLHCRALAEPEPEIYWVTPAG----VRLTPARSGRKYRVFPEGTLELRRVTAEEAGLYT-----CVAQNLVGADTKTVSVVVGHAPFQPGRDKGPGLELHVQETHPYHILLFWAPPPNIVSTNLTWSSAASLRDHETTALARLPRGTHRYNITRLLPATEYWACLQVA--FADAHTQLACVWARTKEASPCHRALGDRPGLIAILALAVLLLAAGLAAHLG-------RGQSKQRVG-EKPLLPVWAFWGWSAPSVRVVSAPIVLPWNPGRKQP---RCQMGKQCHHHCLNIAEAPPGLSSR-------------EITRTTLHQTGRDLGQMPARNAALIDPHA-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M9Q7P8-1", "uniprot_id": "A0A8M9Q7P8_DANRE", "id": "A0A8M9Q7P8-1", "name": "", "aln": "MKMGHIAIFLLH-----------THLLLGVTSSLVIQSMPWRVSCPHQCVCQIKPWYS------------PQSVYREAPTVDCNDLLLIQLPTSLPQETQTLRLQSNLISSVDQSELQGLVNLTELDLSHNSFTSTRNLRITDLPALLSLHMEENQLRHLPEAAFFGLSNLQELYLNHNRLRSISPGAFKGLDRLLRLHLNSNRLVVID-RRWFHALQQLEVLMIGGNPVEIIQDLNFKPLGSLRSLVLAGMGLREISERALEGLQNLESISFYDNSLIKVPKEALQKLPGLKFLDLNKNPIQLVQRGDFRNMLHLKELGLNNMEELISIEHSAMENLPELTKLEITNNPRLSYIHPQAFQKLLSMESLMLNSNALSALHSQTVRSLPSLQEISLHSNPIRCDCLIRWVG-ADNDKPVRFIEPQSTFCSEPPELKARRVKEVSFREMADSCLPLIAPSTFPSYIEVKHGDNVALHCRALAEPEPNIYWVIPQG----VRLTPSSSYGRYQVLTEGTLQIFGVTAEEAGFYT-----CVAQNLVGADTRSLTLQVEGSNLIRGRTQRREDSFEVQDVKERYALLSWQASHNVPTAHLSWVANGSLEDHHRHS-TRILAGTRRFNLTRLQPGTHYKVCLHLG--PNDTS----CVHLRTKEVS-MPDPLPDLTPAVLLAVSALLLLLAARACHGG-------ASFSWKEHIMEFEKPHTTILTQEAKAFMTVPIPVKCLNQQDQGKVL---SDGRGK----------DLRN----------------------EMLGQVAQGLTKEAC-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9PFH7-1", "uniprot_id": "M9PFH7_DROME", "id": "M9PFH7-1", "name": "", "aln": "--MQRNMMIAF-------------VGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFP-WKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNP-AMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMIS--EKKLNNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATATVG-----DSCYSYADVPMVHGAPLGGPNQPQ---LRLTQEHFK--QRELYDQEMG-------SEILDHNYIYSNTHYSMPLEQLGRSKTPTPPPMPPALPLRNGL------CATTGRRSFQQK----SASQKQQQ----------------NNNTLRQFTHX----SSTYRRRQLSIYA------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0S0WP14-1", "uniprot_id": "A0A0S0WP14_DROME", "id": "A0A0S0WP14-1", "name": "", "aln": "--MSRRRAITMSLAPHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVP-WADLQTLDLSENPFECDCRLLWLRHLLVSRNASG-QYAPVICAYPTALRDLPLAHLAE-PLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKG----HSALGRKEREYQKTFSDEEYMSRPP--PGGGGVHP------AAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLACNGGKPLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHYGGVYAKPCDAMSEPGYIHNNSHYSLPLDHD-LPPSPTPTPPPPALPLRNGVGMALIHGNTTGRRSFNNNNNVSTLSNNNHHGIGGGVGVAVGGTVGNNNGSLRRYHXYPAKTCGTLGRTIIKTRPDPDIELHYFYKG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . ** * *: . . . : .:. *.: . : * *. * : : : : :* *:.*.:*.: . : : *. : *::. * : .* :* : : ** *..*:: : * *:.**..* *:*:.* * .: *. : .* * :* * . * *: * .* * * * .*::** :: ** .*. :.: ** * :* .:.:: *: *.:.:* :: : * * .: .*:.* :.. .* : *: . :* *:::.* * : *: * :. ::*: * *::* . . .** :.* **: *** : * : . : :* * *: : .: : . :: : * . :. . .* . .* * : . * :. . *.:. .* . : : . . * : . . .: . . * * . *. * : ", "identical_positions": 95, "similar_positions": 162, "identity": "11.46%" }, { "cls_id": "homologset.agr.HGNC:16915", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7TSE9-1", "uniprot_id": "HAX1_RAT", "id": "Q7TSE9-1", "name": "HCLS1-associated protein X-1", "aln": "MSVFDLFRGFFGFPGPRSHRDPFFGGMTRD----DDDDEDD--EEEEDSGAWGRESYAFDG-FHPTEEFGF--SFSPRGGMRFHGNFGFDDLVRDFN----SIFSEMGAWTLPSHSP-ELPGPESETPGVRLREGQTLRDS---MLKYPDSHQPRIFEGVLESHAKPESSKPAPDWGSQGPFHRLDDTWPVSPHSRAREDKDLDSQVS-------QEGLGPLLQ---PQPKSYFKSISVTKITKPDGTVEEHRTVVDS------------EGRRETTVTHQEAHDSS-----------------RSD-------------------------PDPPRSSALDDP-----------------------------FSILDLLLGRWFRSR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35387-1", "uniprot_id": "HAX1_MOUSE", "id": "O35387-1", "name": "HCLS1-associated protein X-1", "aln": "MSVFDLFRGFFGFPGPRSHRDPFFGGMTRD----DDDDDDDDDEAEEDRGAWGRESYAFDG-SQPPEEFGF--SFSPRGGMRFHGNFGFDDLVRDFN----SIFSEMGAWTLPSHSP-ELPGPESETPGERLREGQTLRDS---MLKYPDSHQPRIFEGVLESHAKPESPKPAPDWGSQGPFHRLDDTWPVSPHSRAKEDKDLDSQVS-------QEGLGPLLQ---PQPKSYFKSISVTKITKPDGTVEERRTVVDS------------EGRRETTVTHQEAHDSS-----------------RSD-------------------------PDSQRSSALDDP-----------------------------FSILDLLLGRWFRSR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O00165-1", "uniprot_id": "HAX1_HUMAN", "id": "O00165-1", "name": "HCLS1-associated protein X-1", "aln": "MSLFDLFRGFFGFPGPRSHRDPFFGGMTRD----EDDDEEE----EEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFN----SIFSDMGAWTLPSHPP-ELPGPESETPGERLREGQTLRDS---MLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVS-------QEGLGPVLQ---PQPKSYFKSISVTKITKPDGIVEERRTVVDS------------EGRTETTVTRHEADSSP-----------------RGD-------------------------PESPRPPALDDA-----------------------------FSILDLFLGRWFRSR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PB41-1", "uniprot_id": "M9PB41_DROME", "id": "M9PB41-1", "name": "EF-hand domain-containing protein", "aln": "MDILKKMFKSEAAKEPDSSVSASNKDEFRKPQWFEEAETDDELFDDDRKFAFQVFTSPLEMQKHFESQLQRLLESLNDKDDGFERDLKEDFLKPGFESKILKKFEQQKDFSLDTDLDGEIYADQLHSLIQRLNPGENVESGDQVIGNILPSNQHGYRKGVQRAKLTDEEIIMGRIHGTIS-ADGESQSYARPPRPPRNNKPDIMTPMTPMLPRSGMSPFGGVFDGNYQGPKLFSQSVMTKTVRKPDGSYETTKVTQDSSGHKTTTVTRMKDGRKETIVTHDDGAPTVGMGGKQLQQKEEDLAVARGERNIFVTKEGYAMPRNLWXPVVNNYCPNQDKRSLLQQQKQQQQYEDRLKRFVGNIVPHPHNIQIRTYYILVYILLSVWCFR-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.::. : . * * .. . *. :: : :: :: :: . :. : .:: . . *. :: * * .*: . *.: ::* :. *: . : .: **. *:.:... : : *:* ** .:. *. . *: . .: :. *:. .:. *: : :: . :* ::: ** : :*: ...: **** * :.. ** :** ** **:.:. : *.: *: : . *:: : :: ::*. * ", "identical_positions": 44, "similar_positions": 109, "identity": "11.34%" }, { "cls_id": "homologset.agr.HGNC:16916", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P49301-1", "uniprot_id": "CLC10_RAT", "id": "P49301-1", "name": "C-type lectin domain family 10 member A", "aln": "--------------------------------------------------MTMAYENFQNLGSEEKNQ--EAGKAPPQSFLCNILSWTHLLLFSL---GLSLLLLVVISVIGSQNSQLRRDLETLRTTLDNTTSNTKAELQALASRGDSLQTGINSLK----------------------------VEVDDHGQELQAGRGLSQKVASLESTVEKKEQTLRTDL---SEITDRVQQLGKDLKTLTCQLASLK---------NNGS-AVACCPLHWMEHEGSCYWFS-QSGKPWPEADKYCQLENSNLVVVN--SLAEQNFLQTHMGSVV-----TWIGLTD-QNGPWRWVDGTDYEKGFTHWA----PKQPDNWYGHGLGG-GEDCAHFTS-----------DGR----------------WNDDVCQRPYRWVCEMKLAKDS--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P49300-1", "uniprot_id": "CLC10_MOUSE", "id": "P49300-1", "name": "C-type lectin domain family 10 member A", "aln": "----------------------------------------------------MIYENLQNSRIEEKTQ--EPGKAPSQSFLWRILSWTHLLLFSL---GLSLLLLVVVSVIGSQNSQLRRDLGTLRATLDNTTSKIKAEFQSLDSRADSFEKGISSLK----------------------------VDVEDHRQELQAGRDLSQKVTSLESTVEKREQALKTDL---SDLTDHVQQLRKDLKALTCQLANLK---------NNGS-EVACCPLHWTEHEGSCYWFS-ESEKSWPEADKYCRLENSHLVVVN--SLEEQNFLQNRLANVV-----SWIGLTD-QNGPWRWVDGTDFEKGFKNWA----PLQPDNWFGHGLGG-GEDCAHITT-----------GGP----------------WNDDVCQRTFRWICEMKLAKES--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IUN9-1", "uniprot_id": "CLC10_HUMAN", "id": "Q8IUN9-1", "name": "C-type lectin domain family 10 member A", "aln": "--------------------------------------------------MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSL---GLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLK----------------------------AEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLN---------NNASTEGTCCPVNWVEHQDSCYWFS-HSGMSWAEAEKYCQLKNAHLVVIN--SREEQNFVQKYLGSAY-----TWMGLSD-PEGAWKWVDGTDYATGFQNWK----PGQPDDWQGHGLGG-GEDCAHFHP-----------DGR----------------WNDDVCQRPYHWVCEAGLGQTSQESH----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F8W3Q0-1", "uniprot_id": "F8W3Q0_DANRE", "id": "F8W3Q0-1", "name": "", "aln": "---------------------------------------------------------MRVVSSDSGSVTVANTEYTDETESAETSDHTEFWRGDP---SVRRLAAVPSGGRWRWCAGIAGSVAALMLLLLIIT--VSVNHVKFNRKFSATEVRIQNLT----------------------------QIILNVISRTQELEQFGHKINADVSSLEFDQRMTETSMN---NLLESAQALHDKVSELKCHIDKMR---------NNNT-QELCCPDQWSLFSSNCYFFS-TDGMSWDSARDECERKRAKLLILT--SKLEKSFVVSKTKPLF-----YWLGLTDGRTGEWEWLDETPYEMVRSEWR----PGQPDNWKAHGLGG-GEDCAHFHH-----------DGR----------------YNDDHCSRHYRYICKAAASAI---------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TVV3-1", "uniprot_id": "A0AB32TVV3_DANRE", "id": "A0AB32TVV3-1", "name": "", "aln": "------------------------------------------------------MRRGWSLFFNFKNQPLILVPLFLLSQNMEMHSSEEYMKMEV---ECETKQSLCKGRPCSKQTGILVLLGTVGMIIFLVLISIIVQAKKLSDIETLMTDLSSSLD----------------------------SLTSKHEENQQKLERQQNVSYIQVKKQMDTVRASVSSIMS--KLKADSVRTSFMFRHPLERFLIEH---------SSEELESGCSDSAWVPFGNSCYLFS-RDKMNWTEAKDYCEEKGAWLLKIEDDSEDEWQFVTDFANPTH-----YWIGLTDQNTGQWRWADGTNYTMNKEHWG----PGQPDEWTEHSLGEEGEDCAEITY-----------ESL----------------LNDLHCSSKIKFICEMKT------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "B7Z0K3-1", "uniprot_id": "B7Z0K3_DROME", "id": "B7Z0K3-1", "name": "C-type lectin domain-containing protein", "aln": "MPPAGQQLRLTALVYLALGIALLCNGSDGETRQKYANESLADADDPSPVWSQFLEDYVLSQGSSSSGSQRKSKDLPYMGADMGINGPLSYHSSAYKRPGNNIYITRRIGEAVELEPHLRKPVESQSPIVNPQFRPMTNQMLHQQHQQMQQQQQQQQLQQRQQPGFLQQLFGIGGSGGGGGSGTQQQQHVRPVPLQQQQVQQIAQQHPQQQHLVGGQPTTFRAVSENDLYLLGAIEKLVYRVDYLESRVRRSEQLIYYLMAGNNQKEVKDPCPANFTRISDNCYYINSQQQVNWKTANSACKGLNSHLAEFEKVSENEEIMAYLLNQPTHR-GRDYWLGGLN-PGLLWIWSNSAKPVNPNMNLTSIAMAQKGENSTAANLVDSSEQAAEEATGEDVLNNTVQIEGKGRCLRLSYNAGKHSYVYYGQECTSRHYYICEHEDKTLDNKIKKITRELKLFE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IRH8-1", "uniprot_id": "Q8IRH8_DROME", "id": "Q8IRH8-1", "name": "", "aln": "MIRPTLIVVLISLASVDSGHNSPVTTIPVAEPISQVPHGFQLGQNNHISSSSNISRSGGGNGRDKRGAQLDPSEIARQNQITQQIFANYLERRLFPNRTANQKIPTIADILPKPKPSPRPRPRGFAASDGGNFKRSGGGAQRNRLAAAASKRQSGYNR----------------------------KRLREEQEEEEEADDQERDQQPLANQEDFDYDVQESLQSVESEQHDQYYGNIFHRDPSENEVDNDCPN-----CVDESQYTPNKWTMPLLKLGEKRYYLGIFFKANWFKATQYCRYHGMHLASIS--SQEENDRLEKHIRDFGLGHEHFWISGTDLADEGNFFWMATGRPITFTNWN----AGEPNNFRYENGEE--ENCLELWNR----------DGKG-------------LKWNDSPCSFETYFVCEVQPN-----------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VQU4-1", "uniprot_id": "Q9VQU4_DROME", "id": "Q9VQU4-1", "name": "", "aln": "---------------------------------------------------------MFRLSVLVLNLLLVSHEFSAGTAKIEIQPLP------------ALCNGYCFPTLKPVMEYVAIHQDKWNTCTEILANEARKDQIQLNIQLDALKADVSNIK-------------------------------ASQLSKDEKLDRMEREQFAMHESLETINRYLTVKLDR---TKLQLEAIKNTMDYMKAQMDGYF----------SAINGVQCLQPGFEKIGDRYFYIEEDVELNWLDAQAKCRRMGGHLASIK--TKQEFDAIVEKLDDSKS----YFLGVNENTKTGDFVSAASGKSCLYHEWG----PGEPHHNNDQ------ERCVSILR----------------------------KLMHVGNCTYEKRFICQYGI------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . .. . : : * * *. * . : * ::. : : . . : .. * . * ::*: ", "identical_positions": 8, "similar_positions": 25, "identity": "1.75%" }, { "cls_id": "homologset.agr.HGNC:16917", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K1C9-1", "uniprot_id": "LRC41_MOUSE", "id": "Q8K1C9-1", "name": "Leucine-rich repeat-containing protein 41", "aln": "MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTR---PSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDKRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGSLPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMATRRKSEVKQMPRAVPPTRVTRRSTQESLAIGGTDSK--LYLPATSYEASGTKQ-PSAPAAASASSSTSS--KRAPASSASQPKPLKRFKRAAGKKGPRTRQGSGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPENAGPPGHIVGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEHNLSLKRLSFHDMNLADCQSEVLFLLKNLTLQEITFSFCRLFEKR--PVQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSTQAFADYVSTM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5M9H1-1", "uniprot_id": "LRC41_RAT", "id": "Q5M9H1-1", "name": "Leucine-rich repeat-containing protein 41", "aln": "MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTR---PSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDKRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGSLPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMATRRKSEVKQVPRALPTSRVTRRSTQESLTIGGTDSKRELYPPATSYEASGTKQ-PSS-APTAASSSTSS--KRAPASSVSQPKPLKRFKRATGKKGPRTRQGSGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRVLSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPENAGPPGHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLSLKRLSFHDMNLADCQSEVLFLLKNLTLQEITFSFCRLFEKR--PAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSTQAFADYVSTM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15345-2", "uniprot_id": "LRC41_HUMAN", "id": "Q15345-2", "name": "Leucine-rich repeat-containing protein 41", "aln": "MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPNAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTR---PSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKKGARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKR--PAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "I3IS54-1", "uniprot_id": "I3IS54_DANRE", "id": "I3IS54-1", "name": "Leucine-rich repeat-containing protein 41", "aln": "-------------------------------------METTGGNSLLQMCIAKVAQNMDVLERKVLNLPVSLLRDLLPHLNIYYLDRIETAAATKGISTSVIWEKIWKGLDQTWRWKVKSSQSDQSWKQRCLERLFHMLMFTQLKREASYLSNLSDSSVLSITVKHVKVLSLHTSTKNICRLASGDMQPFLSALEKGVTTLKLLES-NSPFKHGRKYLFILHRLLDHGSVRKVVLMRNPE---------------------------------------------------------DSCFLRWLISRR------------------RGPQISVSTEGCGSAVDVFRSGADLEEPAAKR---------------------LALDEEKPEDLCGEFSSSSSSSERCPEG------QIHSLDFEVPN---------------------------------------CEILNMVSHALPTWTCLHTLHVHSDWLISE----------DEMCVFVDSLRRLFLNPAGSLSELSLSHLCG----LTHLINILKACPTLQSLSVDVCLPAERNKWRPLP------------QLPRDKMLSLEKLTVNSTDPMSVQCVLPALALAPELSSLHMTGITLTRHF---FHTLAGCKASLKILKLEDINLSDYHQEILHFLQSSVLEELSFKDCRLLDKCSLKTDFMVAFVEAVKAISSLKTLVLAKNRLATT-AIEISRLFSGCRPSEITTLDLSSNFILPAELLGFAELLETYRPAQRITLDLCFNPLNRDLEVKGQALQKLKPYCNLLMYDWNTRDTMVDHVSVM", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ... :*:::* *: :*.*** * ** .:*:.:** ******:*** :* .**:**..**.::*. * :* .* :* .*: : :* :* :: :. .:. . * * : :**: *:: . :. .*.: : .*.:* ..: ***: . * . :. :**:*:.**:* :* * * : * : :** *..* *:: * . :. ..:. * ..:*: * . :*: * ::.... * :* :::.: * *.. . *::.: .*.* :.* *: *.*: * .:: ::**** * :.. * * **.* . * *::* * *: **: * *::*:: ::*.: : .** ..::* .: * : : : : **. : :: .:.* ::** : :** *.:.*:**:* :.*:*.:*:. .*:*::*. ***::* .:*: :* *:*. *:** * *. ***..: : :: :** .*.: **:*** * * ** **: ** : . * * * *::* . :*:::*:. *::: .*:: :::.*:**.*", "identical_positions": 170, "similar_positions": 224, "identity": "20.81%" }, { "cls_id": "homologset.agr.HGNC:16918", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7TP47-1", "uniprot_id": "HNRPQ_RAT", "id": "Q7TP47-1", "name": "Heterogeneous nuclear ribonucleoprotein Q", "aln": "--------------------------------------MATEHVNGNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVA---------------------------------------------------------------------------------------------GQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPP-DQKRKE--------RKAQRQAAKN-----QMYDDYYYYGPPH--------MPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD---------YYG---------YDYHNYR-------GGYEDPYYGYEDFQVGARG----------RGGRG-ARG-AAPS------RGRGAAPPRGRAG-------------YSQRGGPGSARG-------VRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSG---------NYGYKSENEEFYQDTFGQQWK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TMK9-1", "uniprot_id": "HNRPQ_MOUSE", "id": "Q7TMK9-1", "name": "Heterogeneous nuclear ribonucleoprotein Q", "aln": "--------------------------------------MATEHVNGNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQRE---KQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPP-DQKRKE--------RKAQRQAAKN-----QMYDDYYYYGPPH--------MPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD---------YYG---------YDYHNYR-------GGYEDPYYGYEDFQVGARG----------RGGRG-ARG-AAPS------RGRGAAPPRGRAG-------------YSQRGGPGSARG-------VRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDTKRRQTNNQNWGSQPIAQQPLQGGDHSG---------NYGYKSENQEFYQDTFGQQWK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60506-1", "uniprot_id": "HNRPQ_HUMAN", "id": "O60506-1", "name": "Heterogeneous nuclear ribonucleoprotein Q", "aln": "--------------------------------------MATEHVNGNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQRE---KQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPP-DQKRKE--------RKAQRQAAKN-----QMYDDYYYYGPPH--------MPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD---------YYG---------YDYHNYR-------GGYEDPYYGYEDFQVGARG----------RGGRG-ARG-AAPS------RGRGAAPPRGRAG-------------YSQRGGPGSARG-------VRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSG---------NYGYKSENQEFYQDTFGQQWK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B3W4-1", "uniprot_id": "A0A8M3B3W4_DANRE", "id": "A0A8M3B3W4-1", "name": "", "aln": "--------------------------------------MATEHINGNG-----TEDAMDTAAAVTHSDHFNTLLEAGLPQKVAEKLDEIYLAGLVAHSDLDERAIEALKEFNEEGALQVLIQFKESDLSHVQNKSAFLCGVMKTYRQRE---KQGTKVVESTKGPDEAKIKILLERTGYTLDVTTGQRKYGGPPPESVYTGAQPTVGTEIFVGKIPRDLFEDELVPQFEKAGPIWDLRLMMDPLSGLNRGYAFLTFCTKEAAQEAVKLCNNHEIRPGKHIGVCISVANNRLFVGSIPKSKTKEQIVEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNLVTVEWADPIEDPDPEVMAKVKVLFVRNLANSVTEEILEKAFGQFGNLERVKKLKDYAFVHFNDRDGAVKALTEMNGKELEGEHIEIVFAKPP-DQKRKE--------RKAQRQAAKT-----QMYDDYYYYGPPQ--------MPPPARGRGRGASRGGYSYPPDYYGYEDYYD---------YYG---------YDYHNYR-------GGYDDPYFGYDDFQAPARG----------RGGRGSARGGTSPA------RGRGASAPRGRAG-------------FPQRGGAGAGPGA------SRGLRGGA---RGGVLPRGRGGKGLEAG----------PDMSQ-------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KHI4-1", "uniprot_id": "A0A0B4KHI4_DROME", "id": "A0A0B4KHI4-1", "name": "", "aln": "MLSQMEASKVQKDEGGGEALSRTILKTPSSFRTPSPIPSCSKMAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPP--HWEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLDNHEIKPGKCLKINISVPNLRLFVGNIPKSKGKDEILEEFGKLTAGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHPSIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFSDYRQGGSFGNNVSYYDDMYRWIDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMGVGRGHGITVPRGRVVGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFRGVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPLGTNGEQWYMDTFSAWS-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:: :*** :: * . :::.: .**: ** :*** ****** : ********** : * * * *:* ****:*::****:* **:.* **********::* ******:** .:*** :**: :****:.** : : ***.* *****.***** *::*:***.*:* ** :**:* .****************.**:*: *:*** :*::**** *:**** *:** :.*:*****:****:: *:*: *:: * *:*::*****:*****:**::**.**:*: :***:: ..:**: :**** *:*:** * * *: : . * .*.: * * :* * *.* *::*:.** : **. *:*::* ** .. * : * * *..** * * ::.. **:* : ****. .* .*..:. * ** * . . : * * : ", "identical_positions": 228, "similar_positions": 124, "identity": "29.84%" }, { "cls_id": "homologset.agr.HGNC:16919", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3MIE4-1", "uniprot_id": "VAT1_RAT", "id": "Q3MIE4-1", "name": "NADPH-dependent quinone oxidoreductase VAT1", "aln": "MSAEREATEAATVAAAAEARAET----GAGEGAPSQPPT---VEVASDPQPPPAPEASASASAPP-----LRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQVTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSRVVTHLLALYNQGHIKPRIDSVWPFEKVADAMRQMQEKKNIGKVLLVPGPEKET---------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q62465-1", "uniprot_id": "VAT1_MOUSE", "id": "Q62465-1", "name": "NADPH-dependent quinone oxidoreductase VAT1", "aln": "MSAEREAAEAATVAAATEAGAETGT--GAGEGAPSQPPT---VEVASDPQPPPAPEASASASAPP-----LRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQLTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVGDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVNSVVTRLVALYNQGHIKPRIDSVWPFEKVADAMKQMQEKKNIGKVLLVPGPEKET---------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99536-1", "uniprot_id": "VAT1_HUMAN", "id": "Q99536-1", "name": "NADPH-dependent quinone oxidoreductase VAT1", "aln": "MSDEREVAEAAT-----------------GEDASSPPPK---TEAASDPQHPAASEGAAAAAASPP---LLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKEN---------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8JFV8-1", "uniprot_id": "VAT1_DANRE", "id": "Q8JFV8-1", "name": "NADPH-dependent quinone oxidoreductase VAT1", "aln": "MSGEDAPAQQQNAEEQKQQETKTPAESPKTESKPDPPPTSASTEAAATAAAAADTPAPAAEKAPEEDTFTYRALVLTGYGGYDKVKLQVKKGKP-ALKSGEVMVRVKMCGLNFADLMARQGLYDRLPSPPVTPGMECSGVIEAVGEEVTDRKVGDKVLVLNRSGMWQEVVVVASTHTFLMPEGMSFEEAAALPVNYITAYMMLFDFGHLRPNQSVLVHMAAGGVGIAATQLCKTVNDVTVFGTASASKHEVISQGGVTHPIDYRTRDYVEEVRKISPKGLDIVLDPLGGSDTHKGYNLLKPMGKLISYGAANMLAGQKKNLFAVAKTWYQQFSVHTLSLIQGNRSVCGFHLGYLDSETELIDQAMTAVMDLYRQGKVKPRIDSTYHLEQVGDAMRRMQERNNIGKIILTTEPMKEEEKKEEAKKDEEKKDDKKKDDKKKDDKKKEDKKKDEAKKEEKKDEKKKEEAKKDDKKAEEKKEEVKKEEN", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * :: . *. .. **. .*.*: . .. . ..*: *. *.*****:********* : . * * .*:: :*:: *********.*********. ******* :**: **** * ***.**:*:********** *.*.*.:***:**.*:******* ********:*****:*:*.:************:** ***:**::*************.:.:.********:* ***:*::******:***:******** ***:*******:::** **:*:* *:**:*:*:**::**** :*.*:*.**:**********.*.**:. .:: :: **.**::**:***.: :*:*.***::***::*:**::*.. * ** ", "identical_positions": 239, "similar_positions": 106, "identity": "49.28%" }, { "cls_id": "homologset.agr.HGNC:1692", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P28648-1", "uniprot_id": "CD63_RAT", "id": "P28648-1", "name": "CD63 antigen", "aln": "-----MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFSKSFQKQMQNYLTDNK--TATILDKLQKENKCCGASNYTDWERIPGM--------AKDRVPDSCCIN-------ITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCLVKSIRSGYEVM-------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P41731-1", "uniprot_id": "CD63_MOUSE", "id": "P41731-1", "name": "CD63 antigen", "aln": "-----MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNK--TATILDKLQKENNCCGASNYTDWENIPGM--------AKDRVPDSCCIN-------ITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRSGYEVM-------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P08962-1", "uniprot_id": "CD63_HUMAN", "id": "P08962-1", "name": "CD63 antigen", "aln": "-----MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNH--TASILDRMQADFKCCGAANYTDWEKIPSM--------SKNRVPDSCCIN-------VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM-------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VLH1-1", "uniprot_id": "Q9VLH1_DROME", "id": "Q9VLH1-1", "name": "Tetraspanin", "aln": "----MSLLTGSANAVKYTLFGFNLIFLITGIILIAVGAGVGAVYTGYKLFLAGKFFSIPTFLIVIGSFIIIISFFGCWGALKENYCLVLSFSVMLAIIFILELAAGISGYVLRNDASDLIKTSLTYSLNEYNSINPNATTKLWDDIQDEFECCGVTSYNDWITAF----------PNGDLPISCCNVHVGAVGTFTCNNAQSSVADR-HKVGCLDGFSGYISAHAVSLGAAGVVIAILQFFGVIFACYIAREIKIRNGITGFM----------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A1Z8K7-1", "uniprot_id": "A1Z8K7_DROME", "id": "A1Z8K7-1", "name": "Tetraspanin", "aln": "------MRSCGPSLIKYVLFAFNVLFAISGLGILIAGAVVLADVNEFNHFVEGRVLAPPIVLIVTGLIIFLIASLGCFGAIKESPTLLITFAVLLAVIFIVELAVGIAASVFKKDLEGMVKNSLQESIKRSNSED----TMAWDNIQQKLMCCGVDSPADWRTLS----------ANKTLPGSCCQPQYIDSTVGHCLESPALGKDKYFQVGCVGKLKDRIEKNAIILIGVGIGIAFIQILGIVLACYLANSIRQERAK--------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VID1-1", "uniprot_id": "Q9VID1_DROME", "id": "Q9VID1-1", "name": "Tetraspanin", "aln": "------MASGGLTCVKYLTFFCNLLFALTGLLIFLVGGMVQLNYAHYSNFVSDHVWTAPIILMIVGAAVAVICFLGCCGALKESSCMILSFALLAVVIFLFEIGLGLAGYVKHTGLHQIMESQFNSTMQHYKERAD--YRDAWTLLQTELDCCGINGPNDWETVY----------RNSTLPAACCS-------VINLSEAKECTNTHATQHGCLQKLLEILDSKTLILASVVLGVAGIQMLTILFACCLYRSFRRSYDHV-------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VLH0-1", "uniprot_id": "Q9VLH0_DROME", "id": "Q9VLH0-1", "name": "Tetraspanin", "aln": "MSNRELQLNSGMKCAKYMLIIVSFMFALTAILLIMVGTTIQTIFGDFSLFIDGHFSSPPALLIAIGFILIAVAALGAYGAVKESVMVINLYGVCLFLVFILEVSAAIAAFVMQSQVRGMLIRTMNQALAEYEHDPY--VESGVDFMQSMLECCGVNEPEDWKDYLSANVNFTLGVDDVVVPNSCCGNQ-----PTSLNDSTQMTCMETYDYGCFRKMNFIVSQSAMLIATGATTVAFVQLLGVLCAFMLAKTLRRNKSIREARRWQLQQSLGVLISGGKMAPPQNSAVTGYQQLDNGEQGSHEPYTYTPQSPSVN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . *: . * .: :: * * .:: * : :. .*. ** **. :: :.: ::::.*:. .::. * : . : : . :* *** ** . :* :** . **. : : : : :* ::.: :: : : . :: ", "identical_positions": 24, "similar_positions": 60, "identity": "7.62%" }, { "cls_id": "homologset.agr.HGNC:16920", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R010-1", "uniprot_id": "CIB1_RAT", "id": "Q9R010-1", "name": "Calcium and integrin-binding protein 1", "aln": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEHRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0F4-1", "uniprot_id": "CIB1_MOUSE", "id": "Q9Z0F4-1", "name": "Calcium and integrin-binding protein 1", "aln": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99828-1", "uniprot_id": "CIB1_HUMAN", "id": "Q99828-1", "name": "Calcium and integrin-binding protein 1", "aln": "MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*************************************** *:*:**.**:::*.******************** ******::****************************************:*****:*************************************************************", "identical_positions": 178, "similar_positions": 11, "identity": "93.19%" }, { "cls_id": "homologset.agr.HGNC:16921", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CGU4-1", "uniprot_id": "AGAP2_RAT", "id": "Q8CGU4-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "aln": "MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAVAAG-----GGGSAAVTTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPSAGSPP-LTVPAIPVPATSVTAASTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRASPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKPESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSHLHGQLISLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRK-----------------------------------------QQQLLAACKSLPSSPSHSAASTPVAG--QASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAIS--------AFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LSREPPPS-PMVKKQRRKK-LSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEEN-FEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLG--TTEEP---LGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDP--QLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAAT---------------------------TPSITATPSPRRRSSAASLGRVDTTIALV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UHD9-1", "uniprot_id": "AGAP2_MOUSE", "id": "Q3UHD9-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "aln": "MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAPGARGSEPRDPGSPRGSEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAAAAG-----GGGSAAVTTSGGVGAGAGTRGKLSPRKGKSKTLDNSDLHPGPSAGSPP-LTVPAIPVPATSVTATSTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRTSPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKIESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRK-----------------------------------------QQQLLAACKSLPSSPSHSAASTPVAG--QASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDAEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAIS--------AFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LSREPPPS-PMVKKQRRKK-LSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEEN-FEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLG--TTEEP---LGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDP--QLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAAT---------------------------TPSITATPSPRRRSSAASLGRVDTTIALV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99490-1", "uniprot_id": "AGAP2_HUMAN", "id": "Q99490-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "aln": "MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRK-----------------------------------------QQQLLAACKSLPSSPSHSAASTPVAG--QASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAIS--------AFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LSREPPPS-PMVKKQRRKK-LTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEEN-FEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLS--TSEEP---LGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDP--QLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAAT---------------------------TPSITATPSPRRRSSAASVGRADAPVALV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3ANW4-1", "uniprot_id": "A0A8M3ANW4_DANRE", "id": "A0A8M3ANW4-1", "name": "", "aln": "MNR-TGTSQSK-TTYLISLTLVKVETAEENELEKSRPAVEGAVYSTDGAKHVMHP-GSNNEGEERQK-----------------MGEAEAGESIKFSVEQEILQSPREEKALFTDGVQCGDRQKSMISPTTENGRARESSGIPQTSYP-----RDVARHLGDIPVRATQRP---VSLLKTHGGGRELKESRESIHASSKSLDRKDSRTRIQSPTSPTPGSFRASWAVSEVKP--------------CDDDLKVVGVGMKRPTEGDLIAMRTQSPRAERLKAGSTSLPTPVALITKPQRKGKSRTLDNSDLNCLSEDLLKCKGGQMVPDYRTAQSQGASARDRKMLRFISGIFTKST-------PVAVSTTIVTPVYSLQRESSEEEAS---CANSQEWTLTRTIPELRLGVLGSIRSGKSALVNRFITGSYLPLESHEGGRYKKEVLVEGQSQLLLIREESGPPSAQLCNWLDGLILVFSLENEASFQEVYKNYSELSAHRN--IAEIPIIAVGTQDKISSTNARVIEDKRVQQLCIDVRRCTYYETCATYGLNVDRVFNEMTQKIVAAKK-----------------------------------------QAALLASCKSLPNSPSHSGASTPVSGPGQASNGAQSSDYPSSLPSTPVISHKDIRGGASGDG-----VTQRNPPRRRTSLFANRRGSDSEKRSSDSRSDTS---RSVPIKQGTLWKRSERSLNKEWKKKYVTLSNSGMLTYHSNINEFLQNAQGKEMDLLRVTVKVPGKRLHRAAAPGAPSPGPALVPVPGVNGLSKDK---QTPEGGAASNLLTVEEASRAGLSYPNDQKVKRCPSSVSNKG--FSVDSSIEGATSPPLGKEHMPSSPMTDRKKKKRNRSINLKGDAAAGQAEAKRKMWKLKSFGSLRNINKTEEESVDFIIISSTGQSWHFEAQSQEDRDAWVQAIESQILASLQSCES-RNKARRNSQSEAVALQAIRNAKGNDLCVDCAAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDVWPSELTKVLSAIGNHMANHIWETCTQGCQKLTPEATREQRESWIRAKYEQRAFVSPLPAQCSEDT---MSTWLLKAVINRDLPNLLLLLAHSTKELINIPPEGAGQQHHSALHAACQLGDVVMTQLLVWYGSDVKSKDPQGRTALTLARQAGSKECAEILVQHGCPSETSPTSPTPVLS---------------------------------------RKSSITSVGRVNSRRRVS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NGC3-1", "uniprot_id": "CEG1A_DROME", "id": "Q9NGC3-1", "name": "Centaurin-gamma-1A", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNYHPHSHPHALSHPHPQQVHNQLQNPHQNQLPPPQRHNHAAPTAAASASGAPSS-------------SASASASASILVAHPPQPLISNSLAIRQEIQRFESVHPSIYAIYELIDLLPMADAQIAQSIRDHVVCIEDS--------------------------------------------------------------------------FVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRN--GQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRKSRRRSNLFIPSSSKKADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKS---------IITNSALTSS-------LMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVKKRHRRMKSS-SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQR-VPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSAR--DVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGVI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. : : : .:: * .: : : . . .: .. : :. . . : : . ******::*::*:****::*. .****:*::*::**** *. *. ::***::::**: *:***:*.*.*. ::..* *.:*:*****:* **: * . : :: *. :.: ***** ** ..**: * *.: *. *::**:************:***:: **::: : . : : :.* . : *.:: . * . :.. .. .. . ::: .. . ** * : .*. .:. :.:.. *::****. * *** .*************...* * **..:::::...:***: * .******:: : : : . ..:.. :* * . :. . : . : :: . : . . .. * . : : . . : . * .:.*:: ::** *:: ::: :* *:* .: ***** . *:** ** *:*.:*: ***. ** : * .:: *: * . **. ****.**** *******.*:******:*****:*:*:****.** ** *: **** ** :**: *: * : :::**::* *:*:*** *::** : .. . * ** *: :: :**:. : . : ::.* *. :..:.::***:* *::: * :***.* ** * * *. : ... . .... : *: . . .: : ", "identical_positions": 243, "similar_positions": 277, "identity": "18.97%" }, { "cls_id": "homologset.agr.HGNC:16922", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AWZ3-1", "uniprot_id": "A0A8I6AWZ3_RAT", "id": "A0A8I6AWZ3-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "aln": "MTLQQAGPGERSIGLLREADPLRAVGIHPSAWACPPPRSPPPPRSRDPQAPLGARPAVSARRPPPARPAPARISILNRRPPAPRPTAAGATTRAARNLGRGGGSRTAELCRKRPWDALRPGALDNEAAGAAARRGLCAPRPHLLARRVPCLSAHPAPHGSALRVRTPAVGPRGTRTGGLQGRCSRSLSAGLAARGGRGRRSPPARALHLASSAPEARVPAAGGAGCSRASEGGEAAAAPGDMYLLDGSGEPASSPADTMSRGMPPRKTVYRISVTMVRKEQLAAPAPRPTRRPRPARSPEAPGRLEEEAEEAAAEDPEIGPRAWDFRAFRTRSTGQLELGRLRPCAHDTEPTDLMGSPTTEGPSSPDGEEARAAPLRRSLSFRHWSEPEVPRSPALSGGRRHSSSGSLAWMPDDDVEAD--VVPEPVAGVQPAAEKRNTLDVGEVLSKNDALSDLERWERSKSKNRTLDNSDLQRLERARAAA--------AGPGAASEHRLLRFFSGIFARRDGGPSPRSGA-----LRSRGYFSLRRAPADTHSSSAESIEGSPRRDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPED-MDAGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSTNPRVIDDVRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRK---------------KQQLSIGPCKSLPNS-------PSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTP--------STSQKELR----------IDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLAKDMSSLHISPNSGNVTSAS--GSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSDATVIANSAISSDTGLGDSVCSSPSISSSTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLTGTAE-------------------------EQEENLEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRAKYEQKLFLAPLP-----CTEFSLGQQLLHATAEEDLRTVILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLVQLLIWYGVDVMARDAHGNTALAYARQASSQE----------------------------------------CIDVLLQYGCPDERFVLMATPNLSRKNNSRNNSSGRAPSVI-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BXK8-1", "uniprot_id": "AGAP1_MOUSE", "id": "Q8BXK8-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNYQQQLANSAAIRAEIQRFES--------VHPNIYSIYELLERVEEPVLQN------------------------------QIREHVIAIE-----DAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPE-----GGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSTNPRVIDDVRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRK---------------KQQLSIGPCKSLPNS-------PSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTP--------STSQKELR----------IDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLAKDMSSLHISPNSGNVTSAS--GSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSDATVIANSAISSDTGLGDSVCSSPSISSSTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAE-------------------------EQEENLEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRAKYEQKLFLAPLP-----CTEFSLGQQLLRATAEEDLRTVILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALAYARQASSQE----------------------------------------CIDVLLQYGCPDERFVLMATPNLSRKSNSRNNSSGRAPSVI-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPQ3-1", "uniprot_id": "AGAP1_HUMAN", "id": "Q9UPQ3-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNYQQQLANSAAIRAEIQRFES--------VHPNIYSIYELLERVEEPVLQN------------------------------QIREHVIAIE-----DAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPE-----GGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRK---------------KQQLSIGPCKSLPNS-------PSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTP--------STSQKELR----------IDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSAS--GSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAE-------------------------EQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLP-----CTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQE----------------------------------------CIDVLLQYGCPDERFVLMATPNLSRRNNNRNNSSGRVPTII-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B0C5-1", "uniprot_id": "A0A8M3B0C5_DANRE", "id": "A0A8M3B0C5-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1", "aln": "------------------------------------------------MYLLDGNYPERMERGTPQRKTVYRIS---------------LTLVKKENLQDGGGST------HRRLENPKVSAYRREGASEAQRS-----SQLEELKEVEDETDEFSAHSYMRNFRTFSTG---------------HLELGRLKLLKRAQHAHKERELNQTCILPENGQNKAIENGAPGEKRAEDVDES--DRLKRDAEHGKVCSTAAANGEKTGIRKKILKTSR--------STEEPVSTWPDEPCEEPKS-----------------------------VKTAKESCISSLLAKGNGKSPKPAPQTPPTKRHPS---------LLRRSFSFRHWTGGELIRIRALSKEKHHSSSGCIGRDGEGNQTQPGVVLQNMAFAETDSTEKRNTLDVGEVLNKTDSVTELGRRERMKGKNRTLDNSDLLRLSDKSLVDKEGFIRGMGSRSSGQERKLIRFFSGIFSKKDGTSTPLSSPSNRALRKNGLLGAQQRAEMGYSQSSSESVNGCPLDDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEADVDAGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFALWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTAEVPLVLVGTQDAISAANPRVIDDTRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKVVAIRK---------------KQQLSIGPCKSLPNS-------PSHSSVCAAPVSAVHISQNSNGGGSLSDYSSSVPSTP--------STSQKELR----------IDVPQTANTPTPVRKQSKRRSNLFTSRKGSEPDREKKGMDGRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRAISTCAAPS-PKTNGLTKDMSNMQLGQAPGSVTSSSS-ASQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSGISTDTGLGDSVCSSPSISSTTSPKMDPPPSPHANRKKHRRKKSTSNFKVDGFSGTAEAKHRAWKLNRVGSLRNIYNNSSNAEEQEDNFEFVIVSLTGQTWNFEATSYEERDAWVQAIESQILASLQSCESSKQKSRLSSQSEAIALQSVRNMRGNTRCVDCEAQNPDWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDEWPLELIKVMSAIGNELANSVWEANAQGRLKPAPDASREERERWIRAKYEQKLFLASLT-----CTELSLGQQLLRATAEEDLRLVVILLAHGSRDEVNETCGEGDGRTALHLACRKGNVVITQLLVWYGVDIMARDAHSNTALAYARQANSQE----------------------------------------CMDVLLQYGCPDERYPLMATPNLSRRNNNRNNSCSSMNSAVI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NGC3-1", "uniprot_id": "CEG1A_DROME", "id": "Q9NGC3-1", "name": "Centaurin-gamma-1A", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------MSNYHPHSHPHALS----------------------------------HPHPQQVHNQLQNPHQNQLPPP-------------------------QRHNHAAPTAAASASGAP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSASASASASILVAHPPQPLISNSLAIRQEIQRFES--------VHPSIYAIYELIDLLPMADAQIAQ----------------------------SIRDHVVCIE-----DSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPE-----GGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRK-SRRRSNLFIPSSSKKADKEK---EPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQRAQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEPLKSNSSQQTSGDEGIAMSNSNSQTFIAGEVANAGNKLEAQTPNVK---------KRHRRMKSSS-VKAN----EAD--------------------------DNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESSKTKQATSTDLAAMLAIRQR-VPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVELLEGLGCP-EAAPLTASGTLPRRRDTLGTPYEKSVSGVI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : ** * . . .*: . : . .:: *:********:*****:*::****.* *************:*:****** *******:.:**************.** *** ************:* **:***:**::**::** *:*::********* *******.*****:.*****:******************..**::: * ::*.:.* :: .*. * : *. * .. * : ...::.: .. . .* . ** :** ::* .:.***. ** *:****** . .....*:** : ::..:****:****** * ***.****************:* ***********::****** * .******::* : * : : ..: : :. :. * :* :. :::. :**:. .* . * .. . .*::* * ** * .::* :...*..: . .: :*::. *:*** **:* .*.: *: :::. ** **** .: *:***:. **** ** *:*.:*: **** **** *. ::: *: * : ** **** : **:*******.*:******:*****:*:*:****.**:** :.** :***.******* .:: * **: :::**::***:*:*** * **:.* .. * **:*:.*. *:: : :**: . : .* . . * **.* *** **:.:.***:* *.:: * ...*.***** *.* :::* *** * * *: .*.*: :. ... : : ", "identical_positions": 388, "similar_positions": 240, "identity": "26.23%" }, { "cls_id": "homologset.agr.HGNC:16923", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K2D4-1", "uniprot_id": "A0A0G2K2D4_RAT", "id": "A0A0G2K2D4-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3", "aln": "------------------------MNFQAGGG--------QSPQQQQSLAAPGGGGSGGGGAGGGGQFGGAGPGAGGGGPSQ--------------------------------------------------------------------------------------------------------------QLAGGPPQQFALSNSAAI--------------RAEIQRFESVHPNIYAIYDLIER-------------------------------------------------------------------------------------------------------------------------------------------------------IEDLALQNQIREHVISI---------------------------------------------------------------------------EDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLP-----------NSPSHSAVSAASIP---AVHINQATNGGGSAFSDYSSSVPSTPSIS---------------QRELR----------IETIAASSTPTPIRKQSKRRSNIFTSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRL--PRATPSTAPGTSPRGANGLALERSNTQLG-GTTGRPHSAS---SASLHSERPHR-SAWAGSRP--EGLHQRSCSISSTDQWSAAAA---LPASVQRPASGPAELLSS-SPKLEPPPSPRSNRKKQRRKKSTGTPRPDGPNSAAEETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRT-ARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLP--SSDVP---LGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLA-PTPNRE---PANGTN-----------------PSAELHRSPSIL------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VHH5-1", "uniprot_id": "AGAP3_MOUSE", "id": "Q8VHH5-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3", "aln": "------------------------MNFQAGGG--------QSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGPSQ--------------------------------------------------------------------------------------------------------------QLAGGPPQQFALSNSAAI--------------RAEIQRFESVHPNIYAIYDLIER-------------------------------------------------------------------------------------------------------------------------------------------------------IEDLALQNQIREHVISI---------------------------------------------------------------------------EDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLP-----------NSPSHSAVSAASIP---AVHINQATNGGSSAFSDYSSSVPSTPSIS---------------QRELR----------IETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECRVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRL--PRATPTTAPGTSPR-ANGLAMERSNTQLG-GATGAPHSAS---STSLHSERPHS-SAWAGSRPGPEGLHQRSCSVSSTDQWSEAAA---LPASMQHPASGPAESLSS-SPKLEPPPSPHSNRKKHRGKKSTGTPRPDGPSSAAEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNTALAVQAVRT-VRGNSLCIDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLP--SSDVP---LGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLA-PTPNRE---PANGTN-----------------PSAELHRSPSIL------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96P47-1", "uniprot_id": "AGAP3_HUMAN", "id": "Q96P47-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3", "aln": "------------------------MNFQAGGG--------QSPQQQQ-------------------------------------------------------------------------------------------------------------------------------------------------QLAGGPPQQFALSNSAAI--------------RAEIQRFESVHPNIYAIYDLIER-------------------------------------------------------------------------------------------------------------------------------------------------------IEDLALQNQIREHVISI---------------------------------------------------------------------------EDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLP-----------NSPSHSAVSAASIP---AVHINQATNGGGSAFSDYSSSVPSTPSIS---------------QRELR----------IETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRL--PRATPATAPGTSPR-ANGLSVERSNTQLG-GGTGAPHSAS---SASLHSERPLSSSAWAGPRP--EGLHQRSCSVSSADQWSEATTS--LPPGMQHPASGPAEVLSS-SPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRT-VRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLP--SSDVP---LGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLA-PTPNRE---PANGTN-----------------PSAELHRSPSLL------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AZA0-1", "uniprot_id": "A0A8M3AZA0_DANRE", "id": "A0A8M3AZA0-1", "name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3", "aln": "MGLQEEVQTLMPSGRAEKRGEDEFIAVKSNVGEEDDDNERQANQREERQESPGQRRSAAGKLNRWLYLSSTGNRGWRKGEVLGMRTDRLPILRDNCTQQSSAEHFDFAGVEKALELRTGVCHIPFKELICNAVSVENATESHVVVLQRPAHGLRLLGSRRAMSMFVFPDNNRRQQTTSTNHQDSSTRPHSFCMLEATNSKQVILPTSASTNHGFPDVVQRCRTRRAELRAIDGLKPDMPPSASLLPLRLEEPPIRRTLKSRSKPRPVSMTVLELYKERSGSRDELASHTGTGSLPRPGFRWKWFGRQATGKEMGVTQISAKLKESNKEEAPKKMFGSLRRSLSLRMRRNRNQPEHEDRTELRRTASIGEKSMQSTRPFSYLTGRTLAPACEQDEDQGATQYIQYQTQGKVAVLEVPLRPAKLTKPTKQMQPETSFWQLIASRFKRKEPLSSNKSELSTGSQAVGSHPPVRNKKPDSVAIETLAGIGFRKGQDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLSSYRNAAEVPMVLVGTQDAISAANPRVIDDARARKLSNDLKRSTYYETCSTYGLNVERVFQDVAQKVVALRKKQQLSIGPCKSLP-----------NSPSHSSVPAASIP---SVHINQAANGGG-AFSDYSSSVPSTPSIS---------------QREMR----------IETVAASNTPTPIRKQSKRRSNIFTSRKASD---QTKSIESKTDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRP--PRAVATVAPTASPK-TNGLTKDRSTLQLGIGATSTPHSNS---SSSLQSGGSTAGVALGTNKE---GMHQRSFSVSSAEQWNEAVISTTSANGVSDPLSSASGMSSATSPKLEPPPSPHANRKKHRRKKSTGITKPDSLSAGSEEPEESFEFIIVSLTGQMWHFEASTFEERELWVQAIESQILASLQSCESSKNKSRLGSQSDALAIQSIRN-VRGNSFCADCDAPNPDWASLNLGALICIECSGMHRNLGTHLSRVRSLDLDDWPVELSMVMTAIGNAMANSVWEACVDGYNKPGVDSTREEKERWIRAKYEQKLFVVALP--QSDVP---LGQQLLRAVVEDDLRLVVLLLAHGTKEEVNETYGDGDGRTALHLSCAMANVVITQLLIWYGVDVKSRDARGQTPLSYAQRAGSQECADILIQHGCPAEGGALSTPTATRH---NPNINNNNG--------------QCAELNRSLSIM------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NGC3-1", "uniprot_id": "CEG1A_DROME", "id": "Q9NGC3-1", "name": "Centaurin-gamma-1A", "aln": "--MSNYHPHSHPHALSHPHPQQVHNQLQNPHQN------QLPPPQRHNHAAPTAAASASGAPSSSASASASAS-----------------------------------------------------------------------------------------------------------------------ILVAHPP-QPLISNSLAI--------------RQEIQRFESVHPSIYAIYELIDLLP-----------------------------------------------------------------------------------------------------------------------------------------------------MADAQIAQSIRDHVVCI---------------------------------------------------------------------------EDSFVNSQEWTISRSVPDLRLGIVGSLNSGKSALVHRYLTGSYMQEESPEGGRFKKEVFIDGQSYLLLIRDEGGAPEMQFAGWVDAVIFVFSLENEGSFNTVYNYYTKMAHFRNGQEIPMILVGTQDAISERNPRVIDDTRARKLASDLKRCSYYETCATYGLNVERVFQDACQKILSQRLPLPPQVQPARPTTPQGNRLGLAPYQAPTNGQRGQQQLPLRMSADFAQAEQKLWSLQAASSSTINENNNITKYNPGAANSLQGDCSQVQLRDPRDLAPPPGKELPTPTSTPTTSRK-SRRRSNLFIPSSSKK---ADKEKEPKSSELGSGRSIPIKQGYLYKRSSKSLNKEWKKKYVTLCDDGRLTYHPSLHDYMDDVHGKEIPLQYVTVKVPGQKPRGSKSIITNSALTSSLMANGQR-AQNTLSDGIGCLTLAKDNQRKLSEKLSLLGAGSIAAGAGGEP----LKSNSSQQTSGDEG--------IAMSNSNSQTFIAGEVANAGNKLEAQTP--NVKKRHRRMKSS------SVKANEADDNDGYEFYIVSLDSKQWHFEAANSEERDEWVAAVEQEIFKSLQSIESS--KTKQATSTDLAAMLAIRQRVPGNGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLANSVWESNTRQRVKPTSQASREDKERWVRSKYEAKEFLTPLGNGSSAHPSPSPGQQLIEAVIRADIKSIVSILANCPSEVTNANVSARDVRTPLLLACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPAPPTNGGIPAPQYNVEDTTALVELLEGLGCPEAAPLTASGTLPRRRDTLGTPYEKSVSGVI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: . :.. * . . * :..* : * *:: ::.::*.: . .*: . : *: : :**********:*****:*::****.*.*************:*:*************:.:**************.**:***.*****:******:* **:*****: ::. :**. *:**:********* *******:*****:.****.:*****:************..**::: * : *.:. . ::*::. .:* :..: ** : : **:: .. .*: * ::* * :.:.***. ** *:****:* . .. . * * : ..:****:****** * ***.****************:* ***********:::***** * .******:: .:: : :. :*. :** :.. . * * .:. . * .* . * . . ::..* . :* :: . . . . : : : . **:. .. :*::* **: . .: : ::.:** :*** .: *****:. ***: ** ::: :*: ***. .*: *:: .... *: ::* . **.:* ** ****:*******.*:******:**:**:*:*:****.***** ** *:**::******. ** :: **:****:*:*** * *:..* .* * ****:.**:. *:: :* :**: ..* .* . . * **.* *:.*:.*:.::***** *.::: * .* * *:**: * * *. : ... * :. *:. . . * .* * * :: ", "identical_positions": 367, "similar_positions": 260, "identity": "26.44%" }, { "cls_id": "homologset.agr.HGNC:16924", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LIB6-1", "uniprot_id": "A0ABK0LIB6_RAT", "id": "A0ABK0LIB6-1", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2", "aln": "--MSAVSEVNVDIQDFLMSINLEQYLLHFQEFGFYTVKDCTSINDNVLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVYKTKNGSTPKEQ-HSAPSSSSNTCIEFSDSVTVHRPGPAPSEMVTT----NVLSEGNCHSSTSHDKLSLSSSDLPCPEEEICQNVDSSQDYLFGRVNVKIDSLITQQAVEHTAGEEQTEKVNLVSEDSSKALNTNTECLPSVDHPASETHCGNGTNGVLESFPPSPFFQFQGEMVVNELYVPSSPIHSPMRSRSKLVSRPSRSFLLRHRPVPEIPGSTKSISGSYFRDRKSITTSAGKSLTLKDANEDNSTSIFPYGETFLFQRLESSKKRSIKNEFWAHEDTVKEEAATSRNSILTKSSIYDSRKEKVSEDKVEDIWIPREDKNNLPQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPLSSTSENTDP-STIANAISPYACFYGSSAAKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNND-REMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISVLLSALKSPSLTSQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKTEQDFKSGLGITIIPMNVANVKQIDRAVKQSFEIITPYRSFSFTADSEKEKQEWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPD------------WASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLKKDEEIQMDSPVDKRKIFITQKYKEGKFRKTFLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHCTPYLLAKKAGQSLQMEFLYHNKFSDFPQYDAHSEGGSSQEATQSTFLCDFLYQATASASRVSTEKKLLEETNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLTVHKEDFYLNTGPIFIFEIYLPSERVFLFGAKTSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLCFCLQTQEAQ-EERMHLRRLQELTISTVVQNGEKVDV-----LLLVEKGRTLYIHGYTKLDFTVWRNAIEKAAGTDGNTLQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIYQKDGDPLSISELLESFKKDARSVKLRVGKHQLEDVTGVLKSFLSDIDDALLTKELYPYWVSALDAQDEKQRTDKYRAFICSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKG----QTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKNTQASVHCLMKSLERLKVSQAGDLLIEVFAE-----RKEPDCSIIIRVSPVMEAEELTNDILAIKNILPTKGDIWATFEVIENEELERPLHYTENVLEQVLQWSSLAEPG--SAYLVVKRFLTIDTIKQCREK----SIKEGILKLKEEPSKILSGNKFQDRCVVLRDGHLFIYKDPKS--TKHEKMFPLRLMKFYLGVKKKMKPPTSWGLTACSEKHHWHLCCDSLQAQMEWMASIFIAQHENDIWPPAGKERKRSITKNPKIGGLPLIPIQHEKNATQARKNIEMARAELERLRLSERHDG-DFTDSSLKDRASIIGYCLEHKDEKLRNRARKHRSFNCLEDTEAEVPPGLPKGYKGLKTVKKTEDRNSKATLEPNNKLPSKVIEELSVVLQRSRSHPKELPDEQTL-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BZ05-1", "uniprot_id": "ARAP2_MOUSE", "id": "Q8BZ05-1", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2", "aln": "--MSSVSEVNADIRDFLMSINLEQYLLHFREFGFYTVRDCTSINDSVLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVHKAKNGSTTKEQQHSDPSSSTHTGIECSDSITVHRPGPAPSEMVTT----STLSEGNCQSPKSHDKLCLSSHDLLCPEEELHQNVDSSKDSLFGGVNVKIDPLITKRAVEYTAGEEHTEKGNLTSEDSSKALSTNTECLPSGDCPTSGTHSGNGTNGVLESFPPTPFFQFQGEMVVNELYVPSSPVHGPMRSRSKLVSRPSRSFLLRHRPVPEIPGSTKSIPGSYFRDRRSNTTSAGKSLTLKNSNEDNSTSIFPYGETFLFQRLESSKKRSIKNEFWPHENTVKEEAATTRNSILTQSSIYDNRKEKVSEDKVEDIWIPREDKNNLAQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPLSSTSGNTEPSSTISNAISPYACFYGSSAAKEKCGWLDKLSPQGKRMFQKRWVKFDGLSISHYNND-REMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISILLSALKSPSLASQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRAVKQSFEIITPYRSFSFTADSEREKQEWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPD------------WASINLCVVICKKCAGQHRSLGPKDCKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELQVDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQYDAHFEGGSSQDAAQSSFLCDFLYQTAAAASRVSSEKKLLEDTNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLAVHKEDFYLNTGPIFVFEIYLPSERVFLFGAETSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLCFCLQTQEAQ-EERMNLRRLQELTISTMVQNGEKVDV-----LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIYQKDGDPLHISELLESFKKDARSVKLRAGKHQLEDVTGVLKSFLSDIDDALLTKELYPYWVSALDTQDEKERTSKYRAFIRSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLAMVFSSCLFQTKG----QTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQ--------------VSQAGDLLIEVFVE-----RKEPDCSIIIRISPVMEAEELTNDILAIKNIIPMKGDIWATFEVIENEELERPLHYTENVLEQVLQWSSLAEPG--SAYLVVKRFLTVDSIKQCREK----SIKEGILKLKEEPSKILSGNKFQDRCVVLRDGHLFIYKDPKS--SKHDKMFPLRAMKFYLGVKKKMKPPTSWGLTVYSEKHHWHLCCDSLQAQMEWMASIFIAQHENDIWPPAGKERKRSITKNPKIGGLPLIPIQHERNATQARKNIETARAELERLRLSEKHDPRDFTDSSLKDRASLIAHCLEHKDEKLRNRARKHRSFNCLEDTEAEGPHGLPKAYKGPKTLKKTEERNSKATLDADPKLPSKVIEELSVVLQRSRPLHKELPDEQTLQKEVK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WZ64-1", "uniprot_id": "ARAP2_HUMAN", "id": "Q8WZ64-1", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2", "aln": "--MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQIILSKMQDIPIYANVHKTKKNDDPSKD-YHVPSSDQNICIELSNSGSVQTSSPPQLETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPT-AEEPHLNLGSLNDSLFGSDNIKIESLITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGSPPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVSGSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGEALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEECFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNE-KEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPD------------WASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQ-GDRMHLRRLQELTISTMVQNGEKLDV-----LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKG----QTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQ--------------VSQAGDLLIEVYVE-----RKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPG--SAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKS--SKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDK-ESVDSSLKERASMVAHCLEHKDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVIEELNVVLQRSRTLPKELQDEQILK----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VX92-1", "uniprot_id": "Q9VX92_DROME", "id": "Q9VX92-1", "name": "", "aln": "MEQARPVPAPRRLYPELRPANYENIEIRRPNSPSNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQENNSDSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRI------LRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPD--PNGHHPQAESSSAEQSSGSQDGD--------DDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRN--FKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFN----TIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPD----PDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYG----KLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVP-LPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKAS-CSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTS--QPKNGNGAGDAMSSNPNLLMTSSSSG------NVKQQRVSHLYGVGKESERGVWMQKILESLTNSLPVKYTCHYYRAG--WCYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLG-KLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAET--------LKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQ---LTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKHNYLVVRPVEMLREIQRAVKN------LATVTPGKELRFADSRTKTFKTLQCELRDGKIVVSKKDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAITFVERTQAQIMRS----------------------------------RDAPFIG---------------------------HVLAGSEWGDR--------TIWYSSIWYCLYRDN----------------------------------------------------------ILPPAEIIIK--------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : * . * *: :: : .:.. : .: : . ..:: . : :: : :: :: .. .. .: : * . . : :.. ..* : . . : * .: . : . * . :. : .:: : . : : : * . ..: . . : : ..: :.* :. :.: ::..* ..*. : .: .* .: :: ::. * *: . . . : ..: .. *. : :. ...: ::. . .* *: :. . .: * ::: .:. *. : . * : :* . : : * ::.:. . ::.: .: :*.::* .... . . : *:. ***:* * : . . . * . : . . : : :: ::: :: :. : :: : : **: ..:.:.* . :: * *.*:*.:* . .: .. .* :: :*. :*: :. .** *.* : :... : *..* : ::* :.*: ::. * ::...* . :::. *:. : .: .*.: : : ..:*.*: *:: : :: * : * *:..: * :* : *.: : *: . ..*. ... :. :. *** : : .* *: .: . .: :*:. . :* *.:: * : .. : . . .:: .* . : :: . . . : * : * ::. :.: ..* :*.: * .: . *:. . .:.:. : .:* .. .*:*. ... : * : * : :. .. : * * * . .:* *:.: **. : : : ::*.**: : :.:. :. :::.* *:: ::*: : : .:*: *.:.* .:* :* **** : ***:**:.** ** :* .: **:*.*. : :*:.:*: ** ..:: .::: .**: *** *: *: : ** :* :: . : .:: * :: *..::* ** :: ** :.. . *:*..:**::::.. *: .*. :.:*.:*:.**: * ::* . *::*: : : : *: : *.*:**: * : : :.* . .: :**. * ** .: * :: . : : :*** *:.******: :*:: :*.** .* . ****: . *::. .. : ** :.*: **** :.: *. *. :. : : * . * * ::* . * **.:* ...: : . . * ** . * ** * . * : :** :.: :: .:::: ", "identical_positions": 217, "similar_positions": 570, "identity": "12.34%" }, { "cls_id": "homologset.agr.HGNC:16925", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4LDD4-1", "uniprot_id": "ARAP1_MOUSE", "id": "Q4LDD4-1", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1", "aln": "--MAEGYDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDAGLLDMGMHLPGHRRRILAG----LHRAHAPP-VPLPRPAPRPVPMKRHIFRSPPVPVTPPEPPPTAGEDEGLP------------AAPPIPPR-------RSCLPPACFTPTSTAAPDPVLPPLPAKRHLVEPSVPPVPPRTGPPYPQASLLAKEE-LLLPSVSPRSQPEPAETPSTLLPAFPQGPLQPPSPPPCPPVIPPKPPRLLPEFDDSDYDDVPEEGPGAPASVMTK-EEPLPSRVPRAVRVASLLSEGEELSGDDS--EDDDDHAYEGIPNGG-------WPTSGLNPPLRSLIPDLPLHPMDELPGGPTPITPVIKAGWLDKNPPQ---GSYIYQKRWVR--LDADYLRYFDSNKDAYSKRFVPVACICRVAPIGDQKFEVITNN---------RTFAFRAESDVERNEWMQALQQAVVEHR---------ARFRLSSASVLGVRG-SEQPDRAGSLELRGFKNKLYVAVTG----DKVQLYKNLEEFHLG-----IGITFIDMNVGNVKEVDRRSFDLT----------TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEALIQLFLHLGNGPGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFG--NQEELDKALCAAVTTTDLAETQALLG---------CGAGVSCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPLEKHYSVTLPTVSHSGFLYKTASAGKPLQ------DRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSP----LDTHGFEHTFEVYTEGER------------------------------LYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGP--WEEPLQLRKLQELSIQGDSE---------NQVLVLVERRRTLYIQGERRLDFMAWLGVIQKAAASLGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQ----DYKAGKVVEDLINHYVVVFSVDEEELRKQREEVTAIVKMRVAGT--ASGTQHAGDFICTVYLEEK-KVETEQHVKIPASMTAEELTLEILDRRNVSIRE-KDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGIDSHLVVKKYQSMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRRSVAAFTADPLSLLRHV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AQA1-1", "uniprot_id": "A0A8I6AQA1_RAT", "id": "A0A8I6AQA1-1", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1", "aln": "--MAEGHDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDASLVDMGMNLPGHRRRILAG----LHRAHAPPPVPVPRPAPRPVPMKRHIFRSPPVPVTPPEPPPTAGEDQGLP------------AAPPIPPR-------RSCLPPACFTPPSTAPPDPVLPPLPAKRHSVEPSLPPVPPRTGPPYPQTSLLSKEE-LLLPSVSPWSQPEPTETPSTLLPAFPQGPLQPPSPPPCPPVIPPKPLRLLPEFDDSDYDDVPEEGPGAPASVMTK-EEPLPSRVPRAVRVASLLSEGEELSGDDA--EDEDDHAYEGIPNGG-------WPTIGLNPPLSSLIPDLPLHPMDELPGGSTPTTPVIKAGWLDKNPPQ---GSYIYQKRWVR--LDADHLRYFDSNKDAYSKRFVPVACICRVAAIGDQKFEVITNS---------RTFAFRAESDVERNEWMQALQQAVVEHR---------AHIRLSSASVLGVRGGTEQPDHAGSLELRGFKNKLYVAVAG----DKVQLYKNLEEFHLG-----IGITFIDMNVGNVKEVDRRSFDLT----------TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASINLCIVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIQLFLQLGNGPGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFG--NQEELDKALCAAVTTTDLAETQALLG---------CGAGVNCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPSEKHYSITLPTVSHSGFLYKTASAGKPLQ------DRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSP----LDTHGFEHTFEVYTEGER------------------------------LYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGP--WEEPLQLRRLQELSIQGDSE---------NQVLVLVERRRTLYIQGERRLDFMAWLGAIQKAAASLGDTLSEQQLGDSDIPVIVYRCIDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQ----DYKAGKVVEDLISHYVVVFSVDEEELRKQREEVTAIVKMRVAGT--ASGTQHAGDFICTVYLEEK-KVETEQHVKIPASMTAEELTLEILDRRNVSIRE-KDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGMDSHLVVKKYPSMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRRSVAAFTADPLSLLRHV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96P48-6", "uniprot_id": "ARAP1_HUMAN", "id": "Q96P48-6", "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1", "aln": "--MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRILAG----LLRAHTSP-APAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLP------------AAPPIPPR-------RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEP----LSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGG-------WHTSSLSLSLPSTIAAP--HPMDGPPGGSTPVTPVIKAGWLDKNPPQ---GSYIYQKRWVR--LDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNN---------RTFAFRAESDVERKEWMQALQQAMAEQR---------ARARLSSAYLLGVPG-SEQPDRAGSLELRGFKNKLYVAVVG----DKVQLYKNLEEYHLG-----IGITFIDMSVGNVKEVDRRSFDLT----------TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFG--NQEELDKALCAAVTTTDLAETQALLG---------CGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQ------DRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPP----PDTHGFEHTFEVYTEGER------------------------------LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGP--CEEPLQLRKLQELSIQGDSE---------NQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQ----DYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGT--ASGTQHAGDFICTVYLEEK-KAETEQHIKVPASMTAEELTLEILDRRNVGIRE-KDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VX92-1", "uniprot_id": "Q9VX92_DROME", "id": "Q9VX92-1", "name": "", "aln": "MEQARPVPAPRRLYPELRPANYEN-IEIRRPNSPSNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQENNSDSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSK--CSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESLTNSLPVKYTCHYYR-AGWCYLKNSITSEWSGT-WLVLRKSQRRLIFVSEANGNVEKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLG-KLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQLTLYEVILNDSLERPLHHDTKVFDVILNWSYWPE-EDRKHNYLVVRPVEMLREIQRAVKNLATVTPGKELRFADSRTKTFKTLQCELRDGKIVVSKKDKNDK---------TTIVREIFLQSSTAYLGCERKRDFPWSWAITFVERTQAQ-------------IMRSRDAPFIGHVLAGSEWGDR---------TIWYSSIWYCLYRDN-----------ILPPAEIIIK-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. *. : **. : *: : . :. : :.:.. : .: .::: :. * . . * * . :. . :.* *.. . *: ::. * *** ***: : . : .:..*. .*. . ..*: : *: . . * : . * .:*: .. .: .. * . .. :*: * .. .: . :.. *. .. . * * . *: . . ::. * . * *.*. * . : : : . *. : : * .:* :* * *.* * : : ** * .*: .* :. . * .::::. :.. :*. *: .: *:*** .: ::* : :.** : : : .:: ** : . : : . . *. ::* : *: . . * : : .* : . : *::: ** :: . . : : ::. *:* :**:. . .. * *.: . :.: *: . .: . : * :: : * :. .** * : . : : :: : .. : : :: : :.* * .*: .* . . * *** *: **.. * .: * *.. .. ..: .* : .*: :::. *: : .. . : . : :.. :.* *.:..: * . :*:..* .:* : :. : ::. **. * . *. * . ** . : **: *. : :*:*: . . *:: * :::. .*. . .: :. * * .:: : : *: * *: * :* . . * ::**: : : :: ..* . :*:: ::*: . : * *::.* . * :*.:*** *:**** :*:::: * *******.*. .. ::*:.::* ** .*.:...* : .**:..****:****: *: ::: .:*: .**:. *****.:*..::* *:: ::.** :.. . .*:*..:**::::****: ...: . * . *:.**: * :*. . :*::::: ::.: * .*. ...:::**: : *: : : :**:: :: *:::. : : *: . .. :: .. * :** .:. *****. **: :: . . .. :*: : . : : .: : :.: .. .:.* . : *: *... : : *: :.:: :* ::* ..*** ::* * .*.:*.*..*: : :*. *.*: * * .. : .*: *.. * .:: : ", "identical_positions": 244, "similar_positions": 526, "identity": "15.23%" }, { "cls_id": "homologset.agr.HGNC:16926", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LG94-1", "uniprot_id": "A0ABK0LG94_RAT", "id": "A0ABK0LG94-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPSCVSSCCSTPCCQPCCCVSSCCQP-CCRPSCCQP-CCRPS-------------------------CCESSCCQPRCCISSCCQP--CCRPSCCQSSCCKPCCQPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCSQSC-C", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3ZAY4-1", "uniprot_id": "D3ZAY4_RAT", "id": "D3ZAY4-1", "name": "", "aln": "MTNSCCSSCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPSCVSSCCSTPCCQPCCCVSSCCQP-CCRPSCCQSSCCQPC-------------------------CCESSCCQPRCCISSCCQP--CCKPSCCQSSCCKPCCKPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64526-1", "uniprot_id": "Q64526_MOUSE", "id": "Q64526-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCCQP-CCQPSCCQSSCCQP-------------------------RCCESSCCQPRCCISSCCQP--CCRPSCCQSSCCRPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A2A4M2-1", "uniprot_id": "A2A4M2_MOUSE", "id": "A2A4M2-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCCQP-CCQPSCCQSSCCQPSCCQPSCCQSSCCQPSCCQSSCCQPRCCISSCCQPRCCISSCCQP--CCRPSCCQSSCCKPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYQ4-1", "uniprot_id": "KRA92_HUMAN", "id": "Q9BYQ4-1", "name": "Keratin-associated protein 9-2", "aln": "MT-HCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPACCVSSCCQPCCRPTCCQNTCCRTTCCQPTCVTSCCQPSCCSTPCCQPTCCGSSCCGQTSCGSS-------------------------CGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSNCCQP-----CCRPACCETTCCRTTCFQPT-----------CVSSCCQPSCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ***.*****************:*: **:*. *****:** ********:.***: ** :. * .. * *.****.** :.**** ** .*** .* . * **.* * * :* * * *.* :.** **:* **.***. .. * **:*** * ***.:.. *", "identical_positions": 97, "similar_positions": 35, "identity": "44.91%" }, { "cls_id": "homologset.agr.HGNC:16927", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2A4M2-1", "uniprot_id": "A2A4M2_MOUSE", "id": "A2A4M2-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCCQP-CCQPSCCQSSCCQPSCCQPSCCQSSCCQPSCCQSSCCQPRCCISSCCQPRCCISSCCQPCCRPSCCQSSCCKPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZAY4-1", "uniprot_id": "D3ZAY4_RAT", "id": "D3ZAY4-1", "name": "", "aln": "MTNSCCSSCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPSCVSSCCSTPCCQPCCCVSSCCQP-CCRPSCCQSSCCQPCCCE-------------------------SSCCQPRCCISSCCQPCCKPSCCQSSCCKPCCKPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64526-1", "uniprot_id": "Q64526_MOUSE", "id": "Q64526-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCCQP-CCQPSCCQSSCCQPRCCE-------------------------SSCCQPRCCISSCCQPCCRPSCCQSSCCRPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYQ3-1", "uniprot_id": "KRA93_HUMAN", "id": "Q9BYQ3-1", "name": "Keratin-associated protein 9-3", "aln": "MT-HCCSPCCQPTCCR-----TTCWQPTTVTTCSSTPCCQPSCCVSSCCQPCCHPTCCQNTCCRTTCCQPICVTSCCQPSCCSTPCCQPTCCGSSCGQSSSCAPVYCR-------------------------RTCYHP----TSVCLPGCLNQSCGSNCCQPCCRP----ACCETTC-----CRTTCFQPTCVY-----------SCCQPSCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ***.******** ****:*: **:*. ******** ********:.***: ** :. * .. * *.****.** :.**** ** .** ***.* * *. :* :* :* * * * ..* *.**:***:* **:.:* * **:***.* ***:*. *", "identical_positions": 94, "similar_positions": 34, "identity": "43.93%" }, { "cls_id": "homologset.agr.HGNC:16928", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1AQ85-1", "uniprot_id": "B1AQ85_MOUSE", "id": "B1AQ85-1", "name": "", "aln": "MVSS-CGSVCSEEGCG-QGCCQPSCCQTTCCRTTCCRPSCCVSSCCRPSCCVSSCCRPSCCRPQCCQSVCCQPTCCRPSCCISSCCQPSCGSSSCCGSSCCRP-CCRPCCSPCCSPCCRPCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCAIPCC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYR3-1", "uniprot_id": "KRA44_HUMAN", "id": "Q9BYR3-1", "name": "Keratin-associated protein 4-4", "aln": "MVNSCCGSVCSDQGCGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCCHPSCCVSSCCRPQCCQSVCCQPTCCRPQCCQTTCCRTTCCRPSCCRPQC--CQSVCCQPTC--CCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHCGQSLCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.* ******::*** :.**:** ***********************.** ::***.:**:*.** * **:* **:. ** .:**:*.* .::** ::**** **** * * * **:* * ** . * ..** * .**:*** **:* :* * ** * **", "identical_positions": 99, "similar_positions": 33, "identity": "58.24%" }, { "cls_id": "homologset.agr.HGNC:1693", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7F2B3-1", "uniprot_id": "F7F2B3_RAT", "id": "F7F2B3-1", "name": "", "aln": "MRFPVCLT--LLVLLVAQGTGKDCPHKKAATLLPSFTETPTTTGSTASP---------TTTHR-----------------PTTTSHR--PTTTSHRPTTTSHRP-TTTSHRPTTTSHGNATVSPTTN----SPGFSTVGPHPGPPPPSPSPSPSSTGALGNYTWTNGSQPCVQLQAQIQIRILYLTQGGKKAWGLSVLNPNKTKVQGGCDSAHPHLALSFPYGQLTFGFKQVYSLNLSSSFTLLYPTPRPPKPPPCSMDMDATVPDALSLSVHLKDRHQSHSTVYLNYMAVEYNVSFP-QAAQWTFSAQNSSLQELQAPLGQSFCCGNTSIVLSPAIHLDLLSLRLQAAQLPDKGHFGPCFSCASDQS-LLLPLIIGLVLLGLLTLVLIAFCVTR-RRQSTYQPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P31996-1", "uniprot_id": "CD68_MOUSE", "id": "P31996-1", "name": "Macrosialin", "aln": "MRLPVCLI--LLGPLIAQGTEEDCPHKKAVTLLPSFTMTPTATESTASP---------TTSHR-----------------PTTTSHGNVTVHTSSGPTTVTHNPATTTSHGNATISH--ATVSPTTNGTATSPRSSTVGPHPGPPPPSPSPR--SKGALGNYTWANGSQPCVQLQAQIQIRILYPIQGGRKAWGISVLNPNKTKVQGGCDGTHPHLSLSFPYGQLTFGFKQ--------------------------------------------DLHQSPSTVYLDYMAVEYNVSFP-QAAQWTFMAQNSSLRELQAPLGQSFCCGNASIVLSPAVHLDLLSLRLQAAQLPDKGHFGPCFSCNRDQS-LLLPLIIGLVLLGLLTLVLIAFCITR-RRQSTYQPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P34810-1", "uniprot_id": "CD68_HUMAN", "id": "P34810-1", "name": "Macrosialin", "aln": "MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGP-STATHSPATTSHGNATVHPTSNSTATSPGFTSS-AHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQ--------------------------------------------DLQQK--VVYLSYMAVEYNVSFP-HAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRS-ILLPLIIGLILLGLLALVLIAFCIIR-RRPSAYQAL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5I3-1", "uniprot_id": "A0ACD6B5I3_DANRE", "id": "A0ACD6B5I3-1", "name": "", "aln": "-MHVVSFQANKCSVRQTFNTTQATDAALQLTIQRSFCVRCIEKQTKMKHGLLMIAICIAAAALTSG-----QYSSTLQGGPTSKPDPTTTTTAPPPTTTTTTHAPNTTTHAPNTTTHAPNTTTHAPNTTTHAPNTTTHAPNTTTPIPAPTPP--ANLTVGKYNSSQDGKLCILADFAIGIRVNTSEVN-----DTFIVQPSKTTSSGGCSEKTANINLLFGEGSVILKFVN----------------------------------------------DDTAQKIYVQLVEVDLTYAFNTKVGSKNYSGKNDSLQLFASVPGHYYSCSSQTVYMGNGLSLDLTHNKIQAFNFKNN-EFGTPDVCKADQPDYRVPIAVGIILIILIVIVVIAYLISRKRRTDGYQSL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : .* : *: ** . :. . ::: **:... .. .. .*:.: . .*::* * :* *. :.* :* :: .:. .* *:*:* :. ::*.*. ::..: *: : * **: . . :::*.**. .*.*. .:: * * * : : * : .:. :*:. : *: . :* :... .: .:* **: : : *: :.*.. :: :. .: *** ::** :: .. ** * *:. :*: :*::*: *:.:*:**: : * ** . **.*", "identical_positions": 64, "similar_positions": 125, "identity": "15.8%" }, { "cls_id": "homologset.agr.HGNC:16930", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZAX5-1", "uniprot_id": "D3ZAX5_RAT", "id": "D3ZAX5-1", "name": "Calcium homeostasis endoplasmic reticulum protein", "aln": "MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQ---------QQLICKQQAP-ELEPTSAMPPLPQPPLAPTASLTP--------------------------------------------------AQGTPSMDELIQQSQWSLQQQEQHLLALRQEQVTTAVAHAVEQQMQKLLEETQLDMSEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLHHWSLPHSQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWE-KNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQSLKTQHEEFVSSLAQQQQQQQQQQQP-PQQPPQPQIQLPPMEADVKATPPPSAPPPASAPAPTIPPTTQPDDNKPPIQMPGSSEYDTSAGVQDPAAAGPRGPGPHEQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRD-APWN--NQPDPNWNNQFEG-PWNNQHE-PPPWGGAQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYP-HRFDYPQGDFPADMG-PPHHHPGH-RMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGP-SRSHSRSKSRGRSSSRSSSRSSKSSRSSSRSRSRS---RSRSSSRSRSRSRSRSRS------SRSRSRSRSRSRSKSYSPGRR-RRSRSRSPTPPSAAGLGSN---------------------------SAPPIPDSRLGEENKGHQMLVKMGWSGSG-GLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDEFSTFGARKEEKED", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CGZ0-1", "uniprot_id": "CHERP_MOUSE", "id": "Q8CGZ0-1", "name": "Calcium homeostasis endoplasmic reticulum protein", "aln": "MEMPMPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQ---------QQLICKQQAP-ELEPTSAMPPLPQPPLAPTASLTP--------------------------------------------------AQGTPSMDELIQQSQWSLQQQEQHLLALRQEQVTTAVAHAVEQQMQKLLEETQLDMSEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLH-----HCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWE-KNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQSLKTQHEEFVSSLAQQQQQQQQQQQQQPQPQPQPQIQLPQMEADVKATPPPPAPPPASAPAPTIPPTTQPDDNKPPIQMPGSSEYDTSAGVQDPAAAGPRGPGPHEQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRD-APWN--NQPDPNWNNQFEG-PWNNQHE-PPPWGGAQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYP-HRFDYPQGDFPADMG-PPHHHPGH-RMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGP-SRSRSRSKSRGRSSSRSSSRSSKSSRSSSRSHSRS---RSRSSSRSRSRSRSRSRS------SRSRSRSRSRSRSKSYSPGRR-RRSRSRSPTPPSAAGLGSN---------------------------SAPPIPDSRLGEENKGHQMLVKMGWSGSG-GLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDEFSTFGTRKEEKED", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IWX8-1", "uniprot_id": "CHERP_HUMAN", "id": "Q8IWX8-1", "name": "Calcium homeostasis endoplasmic reticulum protein", "aln": "MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQ---------QQLICKQQTP-ELEPAATMPPLPQPPLAPAAPIPP--------------------------------------------------AQGAPSMDELIQQSQWNLQQQEQHLLALRQEQVTAAVAHAVEQQMQKLLEETQLDMNEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLH-----HCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWE-KNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQQQQQQQQQQQQ---------LQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTTQPDDSKPPIQMPGSSEYEAPGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRD-APWN--NQPDAAWNSQFEG-PWNSQHE-QPPWGGGQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYP-HRFDYPQGDFPAEMG-PPHHHPGH-RMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGP-SRSRSRSKSRGRSSSRSNSRSSKSSGSYSRSRSRS---CSRSYSRSRSRSRSRSRS------SRSRSRSQSRSRSKSYSPGRR-RRSRSRSPTPPSSAGLGSN---------------------------SAPPIPDSRLGEENKGHQMLVKMGWSGSG-GLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDECK-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T8Z4-1", "uniprot_id": "A0AB32T8Z4_DANRE", "id": "A0AB32T8Z4-1", "name": "", "aln": "MDISTPPEDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNAKFSFLFGGEFFGYYKYKLAIEQ---------QQHSGTHDDEYNMEVISNIPGNEAADVSATMAILGPP----------------------------------------------AIPAAAPSMEELIQQSQWNLQQQEQHLLSLRQEQITAAISLAMEQQMQKLLVETQLDMNELDNLLQPIIDTCTKDAISAGKNWMFGNAKTPQHCELMASHLRNRITADEAHFELRLHLIYLTNDVLH-----HCQRKNQKDLLAALQKVVVPIYCTSFLSVEEDKQQKITRLLQLWE-KNGYFDDVTIQQLQSPALGLGQYQASLITEYAPVVQPIQMAFQQQIQALKTQHEEFVSNLNQQQTVAAAAVAV---------AQLTPADAEVTSQTP---------------IASQPADLKPPLSGPPSSEYE---GSQNRSSDS--NPALSPEMSSSKPGWFDPQHNMPAWNPQQPP---PFDPSQ-APPPCPPWN-SHEGLWNEQR-DPNWSDPRDGGPWSGQNDPPPSWSGQYEQPPWSSQQDQPPPWG--QREPPFRMQRPPHFRGPFPPHQQPPPFNQPPPPHNFGRFPPRFMQDDFPPRHHFERPPYPPHHFDYPQGDFPGEIGPPPHHHPNQ-RIPPPGLSDPPPWGGNQH-EFGPPPHGFNGQAPHVRRHNPPHVSQDDPSLVPNVPYFDLPAGLMAPLVKLEDHDYKPLDPKDIRLPPPMPPSDRLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRKKEQDKRSSARGSRSRSRSHSRGRSSSHSSSRSSKSSRSRSRSRSRS---RSRSRSYSRSRSRSQSRSR-----SRSGSRSRSKSRSRSRSPEKRPHATKSRSPTPPSTSGLGSS---------------------------SAAIPPDLRLGEENKGHQMLMKMGWSGSG-GLGAKEQGIQDPIKGGDIRDKWDQYKGVGVALDDPYVNYRRNKSYNFVARMKAREKVSRDPQEPASTE-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q59E33-1", "uniprot_id": "Q59E33_DROME", "id": "Q59E33-1", "name": "", "aln": "-MDVQPPRDASLRNIIDKLAEFVARNGPEFEAITKQKQQNNPKFEFLYGGEFANYYQFRVAAEQALLKQQAINQQLPPGAPSGHYMQHPPPMQQSQPPGLYPPPNQQPPHPPETAQDNMQQQTQHSWPPNSGNGGPPNNQQANGNPMAMNLTSQLEAIKMQQKSLREQIQQSEANLSAQHTALMNQKTKQIEDAIAAAQTAQQEQMAGEQGIVLRDFDGVLQPIIESCTKDSISAGKNWILQHSTDSAKINVVLQYLLKKALVNGSTFQQKLHLIYLVNDILH-----HCMRKNINDLKNSLENVVIPMFCSADLIGNPDQRQKLAKLLSLWESKAKFFDACVISKLQSPDSSMQEYKTNLQNTHHDITAKFTQNTKATLDNYQKQHHVFIQHASQQIVQLEKQAQH-------LEQQIVAQKSQQQHMLQHQ-------------QKNIPSLMSHRIAMPGDHEHMNSQGPHD----------------QQHPQAGNNMYPGGNFQQQQPPPGNHFADPRGPNFFIPDMSKPPPGFPGPMHHNQGPAMGQQ--------QPQPGQFPPMQAPGSGNEPPVDLGVLSAAIQACLQMQQQHHPDDPQQQGQHQLQQQQQQQPQQQKQPPP--------------------------MAAYPQNIVRPGQQNADSSEVDLDVLNAAIRAVITNKPEDGTLEDGQQPQKLVDGESGEPVVIGE--PQIPTAPYYDLPAGLMVPLIRLEDYNYKALDPADIRLPAPAPQSERLTNALNAFYSAPSHDRPRDNEGWEKLGLYEYYKVKNAARKQKEEEIKDGIREKSRSPSPIVLEKPLPKKSNKRVYRSKSRSRSRSKTPPHRDRSLSRSRSRSRSMERSLTPPPMNRSRLGGGNNRKGRNRSPRHERDNNSGSTNTREGRGDRGNSNSRDNGNSTNLRRVDRDRSLTPPSFLGSTFAKPADFIEESNKGHQMLMKMGWAGTGTGLGSKNQGIDTPISGGEVRDRREMYKGVGANMHDPFESFRKNKGAAFAHRMRSRDDKS-----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * .***:*****:********** :* :**::*.**.**:**** .**: ::* ** ** :: . : . : .. *: * ****: .*. *. *: : :*: *:: * * ::: * : : ::*.:*****::****:*******:: ::. . : ::: :* :: .: : *: :****** **:** *. **: .:* :*::**:*::*:: * : *::**:::**.*** * :** *.:**** .: :*::.* . : :. . : :: :.**. *: ** *: .:: . * . : * . *: * :: .:* : : : **** : : * . . *: . : : . :: :* . : ..: :. ::**: * .* *: :* *:: : ** . :* :: * :::.. .: :. :: : *. .* : * . . * : : . :*..**:*******.**::***::**.*** *****.* * *:** *::****.*******:.****: ****:::.* **::* :: :.. . . . :. .:...: * * ***:*:: .** * ******* .** .** . .. :.:. ** :. . . : * . .. *.. *: * : *.*******:****:*:* ***:*:***: **.**::**: : *****. :.**: .:*:**. * **::*:. . ", "identical_positions": 265, "similar_positions": 262, "identity": "25.26%" }, { "cls_id": "homologset.agr.HGNC:16931", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JKR6-1", "uniprot_id": "HYOU1_MOUSE", "id": "Q9JKR6-1", "name": "Hypoxia up-regulated protein 1", "aln": "MAATVRRQRPRRLLCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKEN-----------ERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPH-VALYRSRFPEHELIVDPQRQTVRFQISPQLQFSPEEVLGMVLNYSRSLAEDFAEQP-------IKDAVITVPAFFNQAERRAVLQAARMAG-LKVLQLINDNTATALSYGVFRRKDINSTAQNVMFYDMGSGSTVCTIVTYQTVKTKEA-GMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAE----MSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPD--YESKGIKAHFNLDESGVLSLDRVESVFET-LVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKEEAEPPAEETSQPPPSEPKGDAAREGEKPDEKESGDKPEAQKPNEKGQAGPEGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAELRKLCQGLFFRVEERRKWPERLSALDNLLNHSSIFLKGAR-LIPEMD---QVFTEVEMTTLEKVINDTWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR-----EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASAGDQEEKVIPPAG--QTEEAKPILEPDKEETGTEPADSEPLELGGPGAGPEQEEQSAGQKRP-SKNDEL----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63617-1", "uniprot_id": "HYOU1_RAT", "id": "Q63617-1", "name": "Hypoxia up-regulated protein 1", "aln": "MAATVRRQRPRRLLCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKEN-----------ERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPH-VALYRSRFPEHELNVDPQRQTVRFQISPQLQFSPEEVLGMVLNYSRSLAEDFAEQP-------IKDAVITVPAFFNQAERRAVLQAARMAG-LKVLQLINDNTATALSYGVFRRKDINSTAQNIMFYDMGSGSTVCTIVTYQTVKTKEA-GTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAE----MSLDQIEQVILVGGPTRVPKVQEVLLKPVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPD--YESKGIKAHFNLDESGVLSLDRVESVFET-LVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKEEAEAPMEDTSQPPPSEPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGVPPAPEEEKKQKPARKQKMVEEIGVELAVLDLPDLPEDELAHSVQKLEDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAELRKLCQGLFFRVEERRKWPERLSALDNLLNHSSIFLKGAR-LIPEMD---QIFTDVEMTTLEKVINDTWTWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR-----EVQYLLNKAKFTKPRPRPKDKNGTRTEPPLNASAGDQEEKVIPPTG--QTEEAKAILEPDKEGLGTEAADSEPLELGGPGAESEQAEQTAGQKRP-LKNDEL----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y4L1-1", "uniprot_id": "HYOU1_HUMAN", "id": "Q9Y4L1-1", "name": "Hypoxia up-regulated protein 1", "aln": "MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKEN-----------ERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPH-VALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQP-------IKDAVITVPVFFNQAERRAVLQAARMAG-LKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEA-GMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAE----MSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPD--YESKGIKAHFNLDESGVLSLDRVESVFET-LVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR-LIPEMD---QIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR-----EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAG--QTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRP-LKNDEL----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZUW2-1", "uniprot_id": "HYOU1_DANRE", "id": "Q7ZUW2-1", "name": "Hypoxia up-regulated protein 1", "aln": "--------MREKLSLWAIFCLVVAFLPSQTESVAVMSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKEN-----------ERLFGDGALGVAVKNPKVVYRFLQSILGKTADNPQ-VAEYQKHFPEHQLQKDEKRGTVYFKFSEEMQYTPEELLGMILNYSRTLAQDFAEQP-------IKDAVITVPAYFNQAERRAVLQAAHIAG-LKVLQLINDNTAVALNYGVFRRKDINSTAQNIMFYDMGSGSTTATIVTYQTVKTKES-GTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFNEQKKSK--KDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDLFDRVPGPVKQALAAAE----MSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAVYQAAALSKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAPYPQRKVITFNRYIDDFVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSD--AESKGIKAHFNMDESGVLILDRVESVFET-IVEEK-EEESTLTKLGNTISSLFGGGSS-EPSANVTEPVTDEEEVTPEAGKEQ--DQPEKQEETVQEKPETEEGKEAEPQAEEQKEDKEKAENQGETESEKTEKPEEKTTDEE-----KEADMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDLTDRDLEKQEREKTLNSLEAFIFETQDKLYQDEYQAVVTEEEKEQISGRLSVASSWMDEEGYRAGTKLLKEKLSELKKLCKGMFFRVEERKKWPDRLAALDSMLNHSNIFLKSAR-LIPESD---QIFTDVELKTLEKVINETITWKNETVAEQEKLSPTVKPVLLSKDIEAKLSLLDR-----EVNYLLNKAKFAKPKPKDKAKDKNSTSESSKANSTDDAEKVIPPK---TEDGAEKVKPAEEPPVVEEKAEETILELNPAENTDDKTESTESSKSENHIEDEL----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O46067-1", "uniprot_id": "O46067_DROME", "id": "O46067-1", "name": "Hypoxia up-regulated protein 1", "aln": "------------MKLVLLLSALLAG-IALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDG-----------TRTIGEDAQTIGIKDPNSAYGYLLDLLGKTIDNPI-VDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQESVQQP-------ITECVLTVPGYFGQAEREALLSAAQLAN-LKVLQLINDYAAVALNYGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTK--TDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATKPLEEALASSH----LSLDVINQVILFGGGTRVPRVQET-IKAVIKQELGKNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSFERDPGDG---AAVKQVKRALFALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFT-------KEG------EEKKDNSE------------QEEAANAGEEPSKS-----------EDNEKAKEEDASKEQKSEESTK-----------QDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVAKLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAEIYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEKDVFTQVEIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDR-----EVKYLVNKIKIWKPKVKPAAEKEKKKEEEVVASGSGDDTK---------SEDAE---QQQEQATKEEQQEQEPVDEITPTPAEEETKTPHSEL-------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36016-1", "uniprot_id": "LHS1_YEAST", "id": "P36016-1", "name": "Heat shock protein 70 homolog LHS1", "aln": "-------------MRNVLRLLFLTAFVAIGSLAAVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGSLATRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTN-RSTIAFLVD-NVEYPLEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQ---PVTIEFEGYGYNPHLGGAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIPIVQDQLIKLVSEEKVLRNVNADESAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKLSNE-----------SELYDVFTRGSAYPNKTSILTN----TTDSIPNNFTIDLFENG--KLFETITVNSGAIKNSYSSDKCSSG-----VAYNITFDLSSDRLFSIQEVNCICQS---ENDIGNSKQIKNKG----------------------------------------------------------------------------------------------------------------------SRLAFTSEDVEIKRLSPSERSRLHEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGPKSQVEELSEMVKVYLDWLEDASFDTDPEDIVSRIREIGILKKKIELYMDS-AKEPLNSQQFKGMLEEGHKLLQAIETHKNTVEEFLSQFETEFADTIDNVREEFKKIKQPAYVSKALSTWEETLTSFKNSISEIEKFLAKNLFGEDLREHLFEIKLQFDMYRTKLEEKLRLIKSGDESRLNEIKKLHLRNFRLQKRKEEKLKRKLEQEKSRNNNETESTVINSADDKTTIVNDKTTESNPSSEEDILHDEL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .:: : . **:.** *.: :*. :*.* .*:*:.*. *::** : :: * *. . :. : *: . .: :*** :: * * :.* :: * *: * . ::. **::. : *:. :: :.. :*:* :*.* :*.*:*.*: :: :: *:.: :.*:.: : :* * :.****: . .::.: : . ::. * *:: *** :: : : . : * : :: . :*:**: : * : * :****:: :**.*::*:**: :** ::* : * *:::*: .: *: *** ** :*:* **: :* * :::: :*:****:*. *.* :. ** .**.* : * * : . ..: .: :* .**::. * * * :. : : .:.. :. . : . : * :... :: *: : :. *:. :.. :.: * : : . :: : : :: . :. * **: : :.:: * : . . .: *:: .. *: : . . .:: :: * : : . : * :..::: . :* . : . * *:::* : : . : . :.* * : ::. : : *: : :. . .: * : : : : . : . ", "identical_positions": 125, "similar_positions": 273, "identity": "11.98%" }, { "cls_id": "homologset.agr.HGNC:16932", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O76041-1", "uniprot_id": "NEBL_HUMAN", "id": "O76041-1", "name": "Nebulette", "aln": "MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSS---------------QIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q0II04-1", "uniprot_id": "NEBL_MOUSE", "id": "Q0II04-1", "name": "Nebulette", "aln": "MKVPVSGDVKEETEEENVEQEENQEAKVSLKPVIEDLSMELARKCTELISDIHYKEEYKKSKDKCTFVTDTPMLNHVKNIGAFISEAKYKGTIKADLSNCLYKDMPATIDSVFAREVSQLQSEVAYKQKHEAEKGFSDYTHMKEPPEVRRAMEVNRHQSNISYRKDMQGTHTYTAELDRPDIKKATQISKIISDAEYKKGQGIVNKEPSVIGRPDFEHAVGASKLSS---------------QVKYKEKFDNEMKEKSHHYNPLGSAFFRQHQFAAVLAS-----------------------------------DWEYKRDFEENKGLYHFDAEAPEHLHHKGNATLQSQVKYREEYEKNKGKSMLEFVETPSYQSSKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPAFLHVKHITNLMREKEYKKDLENEIKGKGMELSSEVLDIQRAKRASEMASEK-------------------------------------DYKRDLETEIKGKGMQVSTDTLDVQRAKRASEMASQVRMV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A164-1", "uniprot_id": "D4A164_RAT", "id": "D4A164-1", "name": "", "aln": "MKVPVSGDVKEETEEENVEEEEKPEDEVFLKPVVEDLSMELARKCTELISDIHYKEDYRKSKDKCTSVTDTPTLNHVKNISAFISETKYKGTIKADLSNCLYKDMPATIDSVFAREVSQLQSEVAYKQKHEAEKGLSDYAHMKEPPEVRHAMEVNRHQSNISYRKDVQGTHTYTAEMDRPDIKKATQISKIISNVIS---LSILCNSDFSLFWGEMEHSVDSWKLMTSQLCPELHLDMQIIGEVKYKEKFDNEMKGKGHHYNPLGSASFRQHQLATVLASDVKYKKDVQTMHEPVSDLPNLLFLDHALKASRMLSGWEYKKNFEENKGSYHFDAEAPEHLHHRGNATLQSQVKYREEYEKNKGKTMLDFVETPSYQSSKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPAFLHVKHISNLMREKEYKKDLENEIKGKGMELSSEVLDIQRAKRASEMASEKEYKKDLELEIKGKGMQIDADTLEIQRVKRAAKIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKRASEMASQKQYRKDLENEIKGKGMQVNVDIPDMLRAKRASEIYSQKKYKDEAEKMLSNYSTVAVTPEIQRIKTTQQNISNVSYKEEVRAGTAVRNTPEIERVKKNQHNISSVKG---IKHATAISDPLELKR----------FQYKEPTYKATPVTMTPEIERVRRNQEQLSAVKHKGELKQATSILDLPGLKRVRENQKTISNVYYKGQLGRATALSVTPEMERVKKNQENISSVKYTQDHKQMKGRPCVILDTPALRHVKEAQNHVSMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVQPHVVEMDRRPGIIVDLKVWRTDPGSIFDIDPLEDNIQSRSLHMLSEKASQYQSRLSRSHSGSTFGTGLGDDKSEISELYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSVRSMQHSANLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M1N4X6-1", "uniprot_id": "A0A8M1N4X6_DANRE", "id": "A0A8M1N4X6-1", "name": "", "aln": "------------------------------------MNPHCARCGKIVYATEKVNCLDKYWHKGCFHCEVCKMTLNMNNYKGYEKKPYCN----AHYPKQTFTIVADTPENLRLRQQSELQSQVKYRKDFEQSKGR-GLKFVLDTPELQRLRKAQDQISNAKYHKDFEVSG-------LQGVTQGMRGTYAVRSQMTPNNETVANSTHKAVHQYIMEMDRRPGVIVAP---------------VLPGAYYPNSHSHGHSYMHQTSMHSLRSMQLRSQQMS------------------------------------------MTVYRALYDYMAQDYDEVSFRDGDIIQNVQPIDEGWMYG------------------TVQRTGRSGMLPANYVEGIR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. . ** . : : : : : :. * :::* .: .:. : *. .: :. :. * :.: : ::***:* *::..: ** . .: :.**::: :.: : ** .*:**.: : .:. . : : : . : . : :* . : : : : *. . : : :*. *: : * : :. *.: *: :.: .:.. :*. * : . .*: . : :: : *: ", "identical_positions": 31, "similar_positions": 106, "identity": "3.01%" }, { "cls_id": "homologset.agr.HGNC:16933", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZZR4-1", "uniprot_id": "D3ZZR4_RAT", "id": "D3ZZR4-1", "name": "Protein fem-1 homolog C", "aln": "MDLKTAVFNAARDGKLRLLTKLLASKSKAEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDR----AKGLLGTTVTFDDLMGILCKSVLEIER-------------------------------------------AIKQTQCPADP--LQLNKALSIILHLICLLEKVP----CTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPD-IMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGNIPEKLETFVSLHR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CEF1-1", "uniprot_id": "FEM1C_MOUSE", "id": "Q8CEF1-1", "name": "Protein fem-1 homolog C", "aln": "MDLKTAVFNAARDGKLRLLTKLLASKSKAEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDR----AKGLLGTTVTFDDLMGILCKSVLEIER-------------------------------------------AIKQTQCPADP--LQLNKALSIILHLICLLEKVP----CTVEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPD-IMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGNIPEKLETFVSLHR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96JP0-1", "uniprot_id": "FEM1C_HUMAN", "id": "Q96JP0-1", "name": "Protein fem-1 homolog C", "aln": "MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDR----AKGLLGTTVTFDDLMGILCKSVLEIER-------------------------------------------AIKQTQCPADP--LQLNKALSIILHLICLLEKVP----CTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPD-IMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7T3P8-1", "uniprot_id": "FEM1C_DANRE", "id": "Q7T3P8-1", "name": "Protein fem-1 homolog C", "aln": "MDLKTAVFNAARDGKLKLLQKLLENKSDREVLKLMAEKTNGATPLLMASRYGHLELVEFLMECCCAPVELGGSVNFDGEVIEGAPPLWAASAAGHLKVVQSLLGHGASVNNTTLTNSTPLRAACFDGHLDIVRYLVEHQADLEVANRHGHTCLMISCYKGHREIAQFLLEKGADVNRRSVKGNTALHDCAESGSLEIMKMLLKFGASMEKDGYGMTPLLSASVTGHTNIVDFLTAHPQTGLAERISALELLGATFVDKKRDLLGALQYWKRAMELRHSEAD-CMRREEPLEPEPAYDCSREVSTAEELDGLIADPDDMRMQALLIRERILGPAHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSLLSFAELFSFMLQDR----AKGLLGAGVSFQQLMEILCRSVLEIER-------------------------------------------AVKQPRPSPDPDPAQLSKLLSIILHLICLLEKLP----CSPEQDQHKKETIYRFLKLQACGRNGFSPLHLAVDHNTTCVGRYPVCKFPSLQVASVLLECGADVNSRDLDDNSPLHVAASNNHPD-IMKLLISGGTHFDSTNALQQTACDLLDHTQLAKSLIQPINHTTLQCLAARAIIRHRLVYRGSIPERLEAFVLLHR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VFD5-1", "uniprot_id": "FEM1A_DROME", "id": "Q9VFD5-1", "name": "Protein fem-1 homolog CG6966", "aln": "MDYKFIVFNAARDNNLAQLKATLYNKSSVEVGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCRANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYEIVKYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSLQILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLITLPCVSRESRIHALELLGATYVDRKRDMAAALNLWRRALEERAVEPP---LEKKVQEPVPAYEMVREVTSVEELEEMVLDPDEMRMQALVIRQRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFAELFSFMLVEAGRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADKSPSCSASSSASSSSSTTLLSAHQHDCNHDP--NALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVMGALYRLNRLKVRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKALLEVGADPNAIDEAGNTPLHLATMQPYVEPLSHILLEGGAHLDTKNYAGETFESLLAPTPMHK-IIDPMKYTTLACLAARTIKKHDIRYEGTVPATLYEFIELH-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * *******.:* * * .**. ** .*:: *.******:::.* ** ::**:*: * * :* ***.**** **.*****.*:***** :*: *: :**.**.** ************** :**:***.* **:**:**********:***** .***:**. .***** *****************:*:::** . *.*: * *******:****** **:.* . .. .** ********:**:***: .**: *::*:: * : . **: :**.:.***: :: ***:******:**:*****:*********:*** ***:*.*.***.**.*** ***. *:****** ************** : .:* : . : :.:: *: ::* *:** : :* ** *.: : :*: ***..: : * : ::**: :*: : . :.** * :: * .**** *:***: :: *:* *** * * .*:***:*: : : : : ::*:..*:*:*:.* :* .** . : * :*:*:::*** *****.* .* : *.* :* * *: ** ", "identical_positions": 312, "similar_positions": 157, "identity": "46.5%" }, { "cls_id": "homologset.agr.HGNC:16934", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4V890-1", "uniprot_id": "FEM1A_RAT", "id": "Q4V890-1", "name": "Protein fem-1 homolog A", "aln": "MDLHTAVYNAAHDGKLLLLQKLLAGRGREEIEELLGEVAGGGTPLLIAARRGHLDVVEYLVDNCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHGQLSG----TELPGE------GSSQMAGNHCST-----PEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGG--DYLPKPEPQQLVLAYDYSREVSTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRS---AKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTK-----------------------------------------------AIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGIFPSLQVVKVLLDCGADPDSRDFDNNTPLHVAAQN-NCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTMQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z2G1-1", "uniprot_id": "FM1AA_MOUSE", "id": "Q9Z2G1-1", "name": "Protein fem-1 homolog A-A", "aln": "MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSG----TELPGE------GSSQVAGNHCST-----PEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGG--GYLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRS---AKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTK-----------------------------------------------AIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQN-NCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8C0T1-1", "uniprot_id": "FM1AB_MOUSE", "id": "Q8C0T1-1", "name": "Protein fem-1 homolog A-like", "aln": "MDLHTAVYNAAHDGKLPLLQKLLASRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLHRGASVNRTTCTNSTPLRAACFNGHLDVVRCLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLSCHARMERDGYGMTPLLAASITGHTNIVEYLIQEQPSHEQLSG----TELPGE------GSSQMAGNHCST-----PEDAEQYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGG--GFLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDHS---AKGNLGMQLDFADLIGVLSKGVREVERALQLPKEPDDSAQFTK-----------------------------------------------AIAIILHLLYLLEKVECTPRQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGQYHVGVFPSLQVVKVLLDCGADPDSRDFDNNSPLHIAAQN-NCPAIMDALIEAGAHMDATNTFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BSK4-1", "uniprot_id": "FEM1A_HUMAN", "id": "Q9BSK4-1", "name": "Protein fem-1 homolog A", "aln": "MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGG--EYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRA---AKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTK-----------------------------------------------ALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQN-NCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P9Z4-1", "uniprot_id": "FEM1A_DANRE", "id": "Q6P9Z4-1", "name": "Protein fem-1 homolog A", "aln": "MDISAAVFNAARDGKLKLMQKLLINKSPEERAALAEERTEGGTPLLIAARYGHLPVVHFLLERCGANVALGGSVNFDGETIEGAPPLWAASAAGHLPVVKALLEHGAPVNNTTLTNSTPLRAACFDGHLEIVRYLV-EHQADLEVANRHGHTCLMISCYKGHREIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMKMLLKCDARMERDGYGMTPLLAASVTGHTNIVEFLVHQPR----------------------------------------------------ASREQRIHALELLGATFVDKKRDLLGAMRYWRRAMELRWAGGQAGALEKPTAGPLVPAYDCSREVSTAEELEALITDPDDMRMQALLVRERILGPAHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSFVLQDR----AKGTLAARVSFQDLMGVLSKSVREVERAVAQRERPPEPPQFSK-----------------------------------------------ALSIILHLLFLLQKLRCGPEQEHLKRQTVYRLLKLNPRARGGHTPLHMAVDRDTTSVGRYPVGRFPSLAVASLLLECGADVDSRDYDNNTPLHIAAAN-GCPDIMAALIRAGAHFDATNAAQQTAYQLLEAQSSGRHALHPLNHTTLQCLAARAVTAHRLPYKGLISEQMEAFIELH", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VFD5-1", "uniprot_id": "FEM1A_DROME", "id": "Q9VFD5-1", "name": "Protein fem-1 homolog CG6966", "aln": "MDYKFIVFNAARDNNLAQLKATLYNKSSVEVGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCRANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYEIVKYLV-HHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSLQILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLITLPC----------------------------------------------------VSRESRIHALELLGATYVDRKRDMAAALNLWRRALEERAVEP---PLEK-KVQEPVPAYEMVREVTSVEELEEMVLDPDEMRMQALVIRQRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFAELFSFMLVEAGRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADKSPSCSASSSASSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVMGALYRLNRLKVRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKALLEVGADPNAIDEAGNTPLHLATMQPYVEPLSHILLEGGAHLDTKNYAGETFESLLAPTPMHK-IIDPMKYTTLACLAARTIKKHDIRYEGTVPATLYEFIELH", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** *:***:*.:* :: * .:. * * . *.***:*:.* ** :*.:*: .* *.* *** ****.**.*****.*:***** :*: *:.:** ** ** ***********:** ::*: ** .* **:*************:***** .**::**. .*:*** *.***************:*:::** * *: * **********:*** ***.*: .*** :.********:**:***: .*:. ****:* * * * * **: ***.: :*** :: ***:******::*:*****:*********:*** ***:*.*:***.**.*** ***. *:****** **:********::* : .:* : : .:: :: *.*:****.: . . *..: *: * * **:. * .: ::*** : * : . *.** * :: * .*:* ***: :.. **: *** :: * .*:***:*: : : *:..***:*:.* :* .** : :.*:::.** *****:: : : *:* :. : **:**", "identical_positions": 293, "similar_positions": 154, "identity": "40.58%" }, { "cls_id": "homologset.agr.HGNC:16935", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q641Y5-1", "uniprot_id": "ATG7_RAT", "id": "Q641Y5-1", "name": "Ubiquitin-like modifier-activating enzyme ATG7", "aln": "----MGDPGLSKLQFAP-FNSALDVGFWHELTQKKLNEYRLDEAPKDIKG--YYYNGDSAGLPTRLTLEFSAFDMSAPTPARCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVGLDQRLSPKQIQALEHAYDDLCRTEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKLTVGVYDPCNLTQHPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNASGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEELIDSHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPAD-LGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEQEGFTFLAKVFNSSHSFLEDLTGLTLLHQETQ--AAEIWDMSDEETV---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D906-1", "uniprot_id": "ATG7_MOUSE", "id": "Q9D906-1", "name": "Ubiquitin-like modifier-activating enzyme ATG7", "aln": "----MGDPGLAKLQFAP-FNSALDVGFWHELTQKKLNEYRLDEAPKDIKG--YYYNGDSAGLPTRLTLEFSAFDMSASTPAHCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVSLDQRLSPKQIQALEHAYDDLCRAEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKITVGVYDPCNLAQYPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPAD-LGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSPKVLDQYEREGFTFLAKVFNSSHSFLEDLTGLTLLHQETQ--AAEIWDMSDEETV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95352-1", "uniprot_id": "ATG7_HUMAN", "id": "O95352-1", "name": "Ubiquitin-like modifier-activating enzyme ATG7", "aln": "MAAATGDPGLSKLQFAP-FSSALDVGFWHELTQKKLNEYRLDEAPKDIKG--YYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQ--AAEIWDMSDDETI---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P38862-1", "uniprot_id": "ATG7_YEAST", "id": "P38862-1", "name": "Ubiquitin-like modifier-activating enzyme ATG7", "aln": "----MSSE--RVLSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTCQPLTVNLDLHNIPKSADQVPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFLHQRALECWEDG-----IKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTVLHVRPEPSLKGLFSKCQKWFDVNYS------------KWVCILDADDEIVNYDKCI------IRKTKVLAIRDTSTMENVPSALTKNFLSVLQYDVP-DLIDFKLLIIR----QNEGSFALNATFASIDPQSSSSNPDMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDLNLKLMKWRILPDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVRQALYNFEDC---GKPKAELAAASLKRIFPLMDATGVKLSIPMIGHKL----VNEEAQHKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIENKTVINAALGFDSYLVMRHGNRDEQSS---------------------------KQLGCYFCHDVVAPTDSLTDRTLDQMCTVTRPGVAMMASSLAVELMTSLLQTKYSG------------SETTVLGDIPHQIRGFLHNFSILKLETPAYEHCPACSPKVIEAFTDLGWEFVKKALEHP-LYLEEISGLSVIKQEVERLGNDVFEWEDDESDEIA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. *.:** *.* **..*::**:: **: :**.: : :. :* .:. . * * :*: . :. * *::.* *.*: **. **:*:*.* * * ** ::: .*::::*******:****: *.: *.* * * : : * : :: *. :: * : :*. * *.. .:.: *...: : *. :*** : : . .: ..::: :* *. ..: . * *: : * *. ***:* :* :.**:*:** :** ::*:.********* **::* *:** : ..* ********** *:*:*:.****::*****..:********.**:**** ***** ** *::*** ::* *.::**** ** : *. * ::*.::*. **..**::***:*:*******:::: :.* *********:::***** :. :.. :******:***** ** ****** ***:***:*::*.:******.*:** .* . .* ** :******** .*. : : *:::*.***.**:: : *: *: *.:: . :**:::**::::**.: . :::: .*:*: ", "identical_positions": 253, "similar_positions": 206, "identity": "35.58%" }, { "cls_id": "homologset.agr.HGNC:16936", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M753-1", "uniprot_id": "F1M753_RAT", "id": "F1M753-1", "name": "Low-density lipoprotein receptor-related protein 11", "aln": "---------------------------------------------------------------------------------------MAARGG-PGPGSRHRALRGLLLLCLWLPGGRPGEP-AAPP---------SGVDRLLQDFRRQLQRARPREELEPELLGG--------------------PQEDCPGAGGTAVYRAVSDTIIRTQDSIAAGASFLRAPGTVRGWRQCVAACCSEPSCSVAVVQLPRGPSVPSPVPAPRCYLFNCTARGRSVCKFAPLRGYRTYT----LSRAGDAAGIS-----PGPGE----------DEPPVSRAGKDVVLRLPTDGVVLDGRESTDDHAIVLYEWTLQQG------DPSSVDMKVPQPGTLKLSHLKEG----AYVFQLT-VTDSVGQRSSDNVSVTVLPRLRSTGGCSSACSRYHFFCDNGCCIDIALACDGVRQCPDGSDEDFCQNLALDRK---------LVTHTVATS--------------------------AQPGATGLNE-----------------------GEG-DPWLEKSQKATTHNQPATVSHPEKRIQPTQKAPESQINPVQPDSNSSGKN--QEE-KYDLKSKSD------QARGEHPAPEAGAVLPLALGLAITALLLLMVTCRLRLVKQKLKKARPIT--SEESDYLINGMYL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CB67-1", "uniprot_id": "LRP11_MOUSE", "id": "Q8CB67-1", "name": "Low-density lipoprotein receptor-related protein 11", "aln": "---------------------------------------------------------------------------------------MATRGGGPGPGFRHRALRGLLLLCLWLPGSRPGEP-AAPS---------SGVDRLLQDFRRQLQRARPREELEPELLGG--------------------PREDCPGAGGTAVYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVPAPMPAPRCYLFNCTARGRSVCKFAPLRGYRTYT----LSRAEDAAGIP-----PRPDE----------DKPPVSKAGKDVVLHLPTDGVVLDGRESSDDHAIVLYEWTLQQG------DPSSVDMKVPQPGTLRLSRLKEG----AYIFQLT-VTDSVGQRSSDNVSVTVLPRPYSTGGCSSACSRYHFFCDSGCCIDIALACDGVRQCPDGSDEDFCQNLALDRK---------LVTHTVATS--------------------------AQPGAMGLNE-----------------------GEG-DPKLEKSQRATTHNQPATVSHPETRIHSTQKAPESQINPVQPDSNSSGKN--QEEGNYDLKSKSG------QAGGEHPAPEAGAVLPLALGLAITVLLLLMVTCRLRLVKQKLKKARPIT--SEESDYLINGMYL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86VZ4-1", "uniprot_id": "LRP11_HUMAN", "id": "Q86VZ4-1", "name": "Low-density lipoprotein receptor-related protein 11", "aln": "----------------------------------------------------------------------------------MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHA--QLSGVEQLLEEFRRQLQQERPQEELELELRAGGG------------------PQEDCPGPG-SGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLG--CYLFNCTARGRNVCKFALHSGYSSYS----LSRAPDGAALATARASPRQEK----------DAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQG------DPS-VDMKVPQSGTLKLSHLQEG----TYTFQLT-VTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRK---------MVTHTAASP--------------------------ALPRTTGPSE-----------------------DAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKN--RKEESYIFESKGD------GGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPIT--SEESDYLINGMYL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B7G6-1", "uniprot_id": "A0A8M2B7G6_DANRE", "id": "A0A8M2B7G6-1", "name": "Low-density lipoprotein receptor-related protein 11", "aln": "----------------------------------------------------------------------------------------------MFPRAHHVLLCAALLWVSSSAGARSSPTSELKSR-------ISGVEELLEEFRKQLQQDEPSS-----------------------------REQEGDGDRCVAGFRAAESRIIRASASIEQGAAFLSAPPRVFSWRDCARACCSLPHCTVAIIQEDLK----QPDDSLRCYLFNCTYRGKSVCSFSYQPGFSTYSRLNDSSGAPGTAATDRPAGRPAPALGEEEAMMQDLDEPPRSDAGQDLVVQLPTDWAVLDGRDSTDDHHITRYEWALVRG------DPS-VKMKVTHPGLLKLSGLREG----VYTFEIT-VIDTAGQKSSDNVSVSVLAPAPNAQVCTGHCSRYQFMCDDGCCIDIGYACDGKQHCPDRSDEDFCQNFDSGRKSSSSKHGADLQTEAAAQTPTEMQHTDISKPEAHQHYGFSNQDPCAAPPVVGPCKGVFPRWYYDSETGICQHFQYGGCKGNHNNFLQKSDCVNECIQKPTVAKHQTTATPLFS-FKSYTTPVASVHQEKRPNPLLDSQNSLAERKTQ------RLLEGHPPPESGAILPLAFGLLISALLLLMVGCRLFLVRRRLKKALPLT--TEESDYLINGMYL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9Y110-1", "uniprot_id": "Q9Y110_DROME", "id": "Q9Y110-1", "name": "MANSC domain-containing protein", "aln": "MIANLALPFLLMIAEAAATAEQVKYLEYLQSSPAEHRLSKRMDLEVCIGHFDVHKNTIIRTGESQAIGGKYLQGIELDTIEECERLCCETDACDVYIFERKAGGYCYLFECGPPEDFRCKFTRHANYTSAVLNPQPKPVGELVTTPRPQLPHIPSNNVSQQEWELSNLKLKPEARDKPTVSTAAVVAPTSGTGTGTGVGLGVGQSPVYQSQSVPAAHCGRFQFTCHSGECIAVYNACDGIPQCEDGSDEGPECNIVLSTATKPATTSSNLEPVKPMVSQYVPVQNVQQTQQVVAQQMQQQQPQQQQQQPQQQPQHVIVLGPPPPPPPPPPMVNNREDAAAWANRKMIAEGQQQLPQQQLQQQQQQQSSQPKTEIINTDAQSHIFSHKGGLQLQQPANGQGPPPSPLQVPGQMAGAGQVQVQGQSPTLQLPGYEANQAVYGMSRTGIYMPQQPAQLQAPAGQQQQQVQASVVWPQQAPLIPQQQSPVQQSQSLMPQQSGHVY------------------------AAAAPAIQSPPAAQQAMLPVLNAAPVAGKNQGPAADGDYDDYDEETYTEAPKKKQHKHKKVKTKTAKDPIELALEQNKLQPEGSLPALPVPASPVHEQYKMIHDNLAMEFRDHDGHSERPGGAVLSLTLGLLVTAALAILIGCRMRTVTRRARRLGGKTPYSQEADFLVNGMYL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: *: . * . . * .*: * ** : . . . * . . : ::. .. : . ** . * * . : . * *..: . . . ** .:: . .. : :*::. :: : : :.. . ..: * *:*. :* :::. .** . :. * :: .: . ** : . . * : :: : :: : .: * * . . : ::: : : :. : . . . : *. **:*.*::** ::. * ::: **: * :: :: * ::*:*:*:*****", "identical_positions": 49, "similar_positions": 118, "identity": "7.01%" }, { "cls_id": "homologset.agr.HGNC:16937", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ES40-1", "uniprot_id": "PRAF3_RAT", "id": "Q9ES40-1", "name": "PRA1 family protein 3", "aln": "----------------MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGIIVVLVFTGFVWAAHN----KDILR-RMKKQYPTA---------FVMV-VMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDSINKFADYISKARE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R5J9-1", "uniprot_id": "PRAF3_MOUSE", "id": "Q8R5J9-1", "name": "PRA1 family protein 3", "aln": "----------------MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHN----KDILR-RMKKQYPTA---------FVMV-VMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNINKFADYISKARE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75915-1", "uniprot_id": "PRAF3_HUMAN", "id": "O75915-1", "name": "PRA1 family protein 3", "aln": "----------------MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHN----KDVLR-RMKKRYPTT---------FVMV-VMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VJ59-1", "uniprot_id": "Q9VJ59_DROME", "id": "Q9VJ59-1", "name": "PRA1 family protein", "aln": "MTTPSTSVGDAAAALSGNLQLPPLRTLDDFILGSARFQLPNLKDFEKWGNRVVKNLLYYQTNYFLLFITIYVLMIFFNPSKIITG-LLVQALIIGVIWQFFSGKSKKNFIASRLTGGNANAAEQNAQQKWYILAGALLGGYLLLHLLSAVLLTIFTVLLPISLTFIHASLRLRNIKNKLTNSIESFAPS-TPMGSLLDALNVRAEGVFN----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::::.***: ***: ** ** *:::*:.**.****.*********::: : :: *:.* ::* * ::* :: *.:* .. *:.: *:. ..: :::. .:*..*:*: ::..*:: :* : :*: * **********:**** *.:*.:. . **** :****: : :.: . ", "identical_positions": 67, "similar_positions": 74, "identity": "30.59%" }, { "cls_id": "homologset.agr.HGNC:16938", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AB13A891-1", "uniprot_id": "A0AB13A891_DANRE", "id": "A0AB13A891-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------MQKAKVRKISTETFTSMLPKERKDQLCDSLGDVDLTLLYKASVHGYKASAFHQRCDHQGPTILVAYNRSGYIFGGYTSVDYTQSGREIKDDEAFLFSFHGGNSSFIKVNSGYNARYDDSGAPNFGHQLYFCYNNQSCVLYKGETSS-------------FNINTSSVYGNDTQLVECEVYKVEQ---DPQVSVEEKPWRKVLWTAERKAELMGLIRSHKPLISSASRVRILMIGPVGAGKSSFFNSINSIFTGHVTSKAMSGSAG----TSLTVQFRTYPINDGREGKPLPFVLCDTMGLEEQSGAGLDIEDISSILQGHIPDRYKFNPAAPFQPDEQKSSRPASLQEKIHCVVYVIDATKISLMS--EKLEEKLSAIRRKVNSLGIAQIVLMTKVDEACPLVDEDLENVYLSSYIKTKVQEVSSRLGVPVSCVLPVKNYSQELELELNCDVLLLTALQQMLRFADDYFDDIQQPVEGKPV-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1RFT6-1", "uniprot_id": "A0A8M1RFT6_DANRE", "id": "A0A8M1RFT6-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------MAPIASDLPAEQREQLCGLLGNVDLTLLYKASVHGYEASAFHQRCDNQGATLLVAYNNSGDIFGGYTSVDYTQSGKEIADKEAFLFSFRSGNLLCIKVKSGYNARCDDAGMPNFGQQLYFCYNNQPVVIYQHKDCYR-----------QFIFNPDTLYGNNNQLTECEVYQIKQ---TLQVSFKEKPWRNILWTAERREELMGFFRSHKPLLSSVNRVRILMLGPVGAGKSSFFNSINSIFMGYVTSKAMSGSAK----SSVTTQFRMYPVKDGHERKPLPFVLCDTMGLEEQSGAGLDIKDISSILQGHIPDRYRFNPVTPFQPDEQKSSRPASLLEKIHCVVYVIDATKISLMS--EKLEEKLTSVRCLINSLAIPQMVVMTKVDEACPHVQKDLQNVYASSYTKMKVQEVSSRLGVPVSCVLPVKNYSQEIELDLNCDVLLLSALHQMLRLADDYLDDVDSF-----------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9P4B9-1", "uniprot_id": "A0A8M9P4B9_DANRE", "id": "A0A8M9P4B9-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------MNPLNSKLTKRQGPQLCDLLGDVDLTLLYKASVHGYEASAFHRRCDNQGPSLLVAYNNSGYIFGGYTSVDYTQSCNAVTDDKAFLFNINGAVPLVIKVNSRHYLRYGGNGGPSFGEQLYFCYNDQPPVYNQGRNAYQVMAFTISPPTMAFTFSPATLYGNNTNLIECEVFKVEQKKDQVNAVIKIKPWRNVQWTAKQRDELMKMIRNYKPLTTSVSQVKILMIGPVRAGKSSFFNSINSIFMGRMTSKAMSGSAG----TSLTTQFRTYPIKDGREGKPLPFVLCDTMGLEEQSGAGLDIEDISSILQGQIPDRYKFNPVTPCQPDEQKSTRPASLQDKIHSVVYVIDATKISLMS--EKPEEKLSAIRKKINSLAIPQVVLMTKVDEACPDVQENLQSVYASSYIKTKVQEVSSRLGVPVSCVLPVKNYSQELELELNCDVLLLTALQQMLNFAEDYLDDVAPM-----------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1PZX7-1", "uniprot_id": "A0A8M1PZX7_DANRE", "id": "A0A8M1PZX7-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGGSDSQPEKPYQPPPPP----PNPELDKPWRQFDWGQ--KEALKKWLENFSPCNPNVKSIKILIAGQAGAGKSSFINSIYCGFQGRISSRALVNSID-GDSRSYTQKLKEFTIK--TEKKTLPLVFRDIMGLEYEEFHGSKTEDIIKAVFGHVKDGYKFNEEQSIDYKDQHYTSDPSLSDQCFCVVYIIDGSTVQFT--DDRLIKKLQIIRKRIKDKGIPQVVVMTKVDEACPLVKKNLRKVYTSKKIKEKMELCSASIGVPMTNIFPVKNYHDEINTNNDVDVLILKALEQIVQIANDRLDDNESY-----------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3AXQ2-1", "uniprot_id": "A0A8M3AXQ2_DANRE", "id": "A0A8M3AXQ2-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGGS---------PSKPA----ETPELDQPWRNFDWGE--KDKLKEHLEYFQLKSQSLTHIKILVAGQIGAGKSSFINSVVSAFQGKIISVAQTDASDSAISHSFTQTLKAYRIR--RADADLPFEICDIMGLEPHTLLGIQPDDVVKTIHGHVKEGYKFTEN-PIGHKNESYKETPSLSDQAFCLVYVVDANTIQFSSNDNILIEKLRLIRKRISDEGIPQVVVLTKVDELCPLVKKDLQKVFYSKKIREAVRMCNSKIGVPMNLIFPVKNYHEETQTNDVADVLILNAFQQIVCTANERLSHGFSHCSD--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0G2JZW5-1", "uniprot_id": "A0A0G2JZW5_RAT", "id": "A0A0G2JZW5-1", "name": "Interferon-induced protein 44", "aln": "MKIAYLQFYPSVVAEFKQLAPSNSSPVERQDYLPIMLSSLGYTDHDAQIHSSPEGASFSVCSMEEALKGRTLFDQAWPLRWKLPSVAALGQNLRPDRFQNFKRTVLALPLDSSMAMRTRLTWEQEKYLRNYFGEKKFCLLYKASVQEFAGQNLLYKCQDQGPTMVVVYSEKYVIG-----VYLQEGFQ-ENKVSTTLFTIQETGLSPCALGPCLPLSLFRYEETS-----DFFILLDKKT----------------------VTISSEIRKVLRLPSLSGDTFIQECEAFRCDELLDE--RKTRGIVGLCSNLLDALRNYKPYGDLVHQTRILLLGPIGAGKSSFVNSVKSVFKGSITHQASVGCDR----NGISDKYRTYSIMSKNDSGPLPFVLCDSLGLSENEG--LHTDDICHILKGHTPDRYQFDFRKPITPNHPNYIHDPLLKDRIHCVVFVFDINSFNQLS--CELVAKIKQIRRDLIKHGILHLALLTHVDSLTWITKGDLLDIYSCNPVKVKLGVFHRLFGFALSDILVVSNYDSEWQLDPVKNMLILSALKEILYTANGFLEDLPLNK----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BV66-1", "uniprot_id": "IFI44_MOUSE", "id": "Q8BV66-1", "name": "Interferon-induced protein 44", "aln": "-----------------------------------------------------------------------------------------------------------------MAMRTRLTWQQEKCLQNYFGGKRFCLLYKASVQKFSHQNLLCTCENQGPTMIVVYSEKCVIG-----MYLKEGFQ-GKDVSITIFALQETGFSLCAKGPDSPYLLFHKRKTN-----DFSILLDEKA----------------------VIVSSAICKMLQLTARNNVIPIQECEAFRCEELLDE--RKTRGIAVLHSNLLQALRDYKPYGDLVQQTRVLLLGPIGAGKSSFVNSVKSVFKGSITHQILVGCDE----DGISDKYRTYSIKAKDDSDPLPFILCDSLGLGENAG--LHTDDVWHILKGHTPDRYQFDSMKPITSNHPNYTHDPLLKDRIHCVVFVFDINSFEMHS--SELVAKIKKIRRDLIKHGILHLALLTHVDSLDLITKEDMTDIYNYSPVKSKLEAFHGVFGFALSDILVVSNYVSEWQLDPVKDMLILSALKEILYTANEFLEDLPLNK----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TCB0-1", "uniprot_id": "IFI44_HUMAN", "id": "Q8TCB0-1", "name": "Interferon-induced protein 44", "aln": "-----------------------------------------------------------------------------------------------------------------MAVTTRLTWLHEKILQNHFGGKRLSLLYKGSVHGFRNGVLLDRCCNQGPTLTVIYSEDHIIG-----AYAEESYQEGKYASIILFALQDTKISEWKLGLCTPETLFCCDVTKYNSPTNFQIDGRNRK----------------------VIMDLKTMENLGL-AQNCTISIQDYEVFRCEDSLDE--RKIKGVIELRKSLLSALRTYEPYGSLVQQIRILLLGPIGAGKSSFFNSVRSVFQGHVTHQALVGTNT----TGISEKYRTYSIRDGKDGKYLPFILCDSLGLSEKEGG-LCRDDIFYILNGNIRDRYQFNPMESIKLNHHDYIDSPSLKDRIHCVAFVFDASSIQYFS--SQMIVKIKRIRRELVNAGVVHVALLTHVDSMDLITKGDLIEIERCEPVRSKLEEVQRKLGFALSDISVVSNYSSEWELDPVKDVLILSALRRMLWAADDFLEDLPFEQIGNLREEIINCAQGKK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *: * :. .. ::*: * ******.**: . * * : . . : : : : **: : * :** . .*: : *: : *:* . .. . * :: ..:.::.* .... *: :* : . .: ::.::*:**. .. :: .: . : : :*..:. : *.** .* : : ::*:*.*:..:: *: :.. ", "identical_positions": 39, "similar_positions": 91, "identity": "6.57%" }, { "cls_id": "homologset.agr.HGNC:16939", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80ZG5-1", "uniprot_id": "SLU7_RAT", "id": "Q80ZG5-1", "name": "Pre-mRNA-splicing factor SLU7", "aln": "-MSAAAVDPVSATPMTGSKEMNLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPT--LKHQRPQPEKQKQFSSSGEWYKRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPD--EHIQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKESVN-SEECIINDATGEEPVKKPQ------------------TLMELHQEKLKEEKKKKKKKKK-HRKSSSDSDDDEERKQEKLKKALNAEEARLLHVKEIMQVDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BHJ9-1", "uniprot_id": "SLU7_MOUSE", "id": "Q8BHJ9-1", "name": "Pre-mRNA-splicing factor SLU7", "aln": "-MSAAAVDPVSATPMTGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPT--LKHQRPQPEKQKQFSSSGEWYKRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPD--EHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKESVN-SEECIITGATAEESVKKPQ------------------ALLELHQEKLKEEKKKKKKKKK-HRKSSSDSDD-EERKQEKLKKALNAEEARLLHVKEIMQIDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95391-1", "uniprot_id": "SLU7_HUMAN", "id": "O95391-1", "name": "Pre-mRNA-splicing factor SLU7", "aln": "-MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPT--LKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIAPD--EHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIVN-SEECIINEITGEESVKKPQ------------------TLMELHQEKLKEEKKKKKKKKKKHRKSSSDSDD-EEKKHEKLKKALNAEEARLLHVKETMQIDERKRPYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5U3F2-1", "uniprot_id": "SLU7_DANRE", "id": "Q5U3F2-1", "name": "Pre-mRNA-splicing factor SLU7", "aln": "-MAAEAGKASEG-------MVDLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPT--LKHQRPQEENQSKFAPIGDWYKRGVQEKSVNTKYRKGACENCGALTHKKKDCLERPRKVGAKFSGTGIAPD--EHQQVQLSMDYDGKRDRWNGYDPDEHMRIVEEYSKVDLAKRTLKAQKLQEELASGKLMDQANSRKH--------EEAVQDHSSEDEDEDKYVDDFDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYSNTGKNPEEVGYAGDNFVRYSGDTISMAQTQLFAWEAYEKGSEVHLQADPTKLELLHQSYKVKKDDFKEKQKETILEKYGGSEHLDAPPRELLLAQTEEYVEYSRHGAVLKGQEKAVAQSKYEEDVLNNNHTCIWGSYWKDGYWGYKCCHSMVKQSYCTGEAGKKVVSNSCTPFEEDVEEAQTSEEPK------------------TLLQMHQEKLKD-KKKKKKSKK-HRDSDSSDEEDEAKKKEKLKKALSAEEQRLKQVAELMQVDERKRPYNSLMEVREPTEEEMEAFRMKRCRPDDPMASFLGQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VAQ7-1", "uniprot_id": "SLU7_DROME", "id": "Q9VAQ7-1", "name": "Pre-mRNA-splicing factor Slu7", "aln": "MSSGPMRTPVSQIILSKHDQDAEEEPKKKSREDWRKAKELEEARKAGTAPAAVDEEGRDINPHIPQYISNAPWYYG-SAGPT--LKHQRPQHEDEQ--GQLDKRAPKGLNTARIITKFRKGACENCGAVTHKRKDCLERPRKVQAKYAESIVVHD--EHLVNEAAVNYDEKRDRWSSYDPANHREIIEEYEKVEEAKRQLKAEKLKNDPD-------------------------AEISDEEGNEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYDPKTRSMRDNP--NPAVPEEEAEFAGENFVRFSGDTTAQATAQLFAWEAHGKGVDVHLLAEPTKLELLQKEYEQKKEQFKSSTKTHIVEKYGGEEHLQVPPKSLLLAQTEEYIEYSRSGKVIKGVEKPKARSIYEEDVYINNHTTVWGSFWNAGRWGYKCCKSFIKNSYCVGMQEPEGYSEHHSTSSTAAATTEPAAQSQFKVPEVPPERPTSEVDSASSSEPSSSEEEEVKPEKKKTKKKSKKREKKKKAKEQRKQ-KGKNKETKDKDKTKEKDIPEELDDRKRAYNSMYDVKAPTEDEIEEWKKKRPRAEDPMLQFM--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q02775-1", "uniprot_id": "SLU7_YEAST", "id": "Q02775-1", "name": "Pre-mRNA-splicing factor SLU7", "aln": "-MNNNSRNNENRSTINRNKRQLQQAKEKNENIHIPRYIRNQPWYYKDTPKEQEGKKPGNDDTSTAEGGEKSDYLVHHRQKAKGGALDIDNNSEPKIGMGIKDEFKLIRPQKMSVRDSHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSRKDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWD-----------------------TDEEIELMKLELYKDSVGSLKKDDADNSQLYRTSTRLREDKAAYLNDINSTESNYDPKSRLYKTETLGAVDE-----------------------KSKMFRRHLTGEG--------------------LKLNELNQFARSHAKEMGIRDEIEDKEKVQHVLVANPTKYEYLKK-----------------------------------------------------------------------------------------------------------------KREQEETKQ--------------------PKIVSIGDLEARKVDGTKQSEEQRNHLKDLYG-----------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : :* . . : . : ... .:: : :. .: .. : .. . : * : . .. : : .. . *.*** **.***:*:**:: . : ::* ::*** .*. :: .::.:: : . * * :. :: : . * . : * *... . .: :: . *:*** * **.:::...: ****:* : :. :::* . :* * ::::. : * .* : . :*. . ** : * ::::.*: : . . . . : ::::. :.: ", "identical_positions": 46, "similar_positions": 127, "identity": "7.53%" }, { "cls_id": "homologset.agr.HGNC:1694", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q07108-1", "uniprot_id": "CD69_HUMAN", "id": "Q07108-1", "name": "Early activation antigen CD69", "aln": "-----------------------------------------------------------------------------------MSSENCFVAENSSLHPESGQENDATSPHFST-------------------RHEGSFQVPVLCAVMNVVFIT---ILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDW-VGYQRKCYFIS-----TVKRSWTSAQNACSEHGATLAVIDS-EKDMNFLKRYAGR---EEHWVGLKKEPGHPWKWSNGKEFNN------------------------------WFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P37217-1", "uniprot_id": "CD69_MOUSE", "id": "P37217-1", "name": "Early activation antigen CD69", "aln": "-----------------------------------------------------------------------------------MDSENCSITENSSSHLERGQKDHGTSIHFEK-------------------HHEGSIQVSIPWAVLIVVLIT---SLIIALIALNVGKYNCPGLYEKLESSDHHVATCKNEW-ISYKRTCYFFS-----TTTKSWALAQRSCSEDAATLAVIDS-EKDMTFLKRYSGE---LEHWIGLKNEANQTWKWANGKEFNS------------------------------WFNLTGSGRCVSVNHKNVTAVDCEANFHWVCSKPSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M9PFV8-1", "uniprot_id": "M9PFV8_DROME", "id": "M9PFV8-1", "name": "", "aln": "MCGSHKMWCCQVFILALFAHTIAVEFHGSAARAEINFEGPSPAHSQDTAAPTSRPKRRVYALCPPKFHRVGTDCYSLVDQRSSWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQDALSGENDPIWLGATYDHHNNRWQWSMSGRNLSTDSFSRTDSAYVQLISNSQPLDNNCAIYDPSLKYRWSARPCSDKLRFICQHKMPKVSGPNRYKIYNRWNATYPNEQANEVVLEILEPRENDRRYHRRVKAEDSDEEMIIPDRRRNNNRRNNHRNRQIKNQNQHPNDVNYQPAQQRQRNRPRTSTVAPTTTQSVSQSNDVLAPSPTPQQMTQYDRKLQRQRERERRRQLRRQERQKLAREQKRERQRRLKEERQRLQREEQQRRQRLHHDEPKPQVNPQVKPQVIDELRQRSGEDLDKNQTDEHEQKLRNEQEKKLREEQQKQRDEQEQKDREEQDRLKQEEEQARTHQKELKENQEQQLRELKAKQEREKQERDYQQQKREHELELLKQRQAEADRQHAADEEAEKLRLERIQKQRELEAQQRREREEQRRKQREEQEEQDRQNHAKRLAEEKRLHDLYAERIRLANTEREKQLAEAHEAKRLEELKLQEQLKKQEDERQEQIRREQEEEEKRLELERLEEARRFEEKELKRLHEENQRREEQKLQREREIALREAAEKKLAEEEEMLRKEVAEEERKVKQRLEDEMRQAEEARKAKEAEERAAEEAKAAEQKRRVEAAKKKADEEVKAKLEEKRREYVTRISALSPEDQKKFIEMRKRRKQLKEKKERDQRAKELKRIQQAMRLDDNE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : ::.: * *:. . . * :*:. * .: : . :: : **: . * . * . .*.:. . ::. .* . . * : . . ..* :::. *:* : :* .. * : :.. .: : ..::::. .:: *. : . . : : :: .: : ", "identical_positions": 18, "similar_positions": 77, "identity": "2.23%" }, { "cls_id": "homologset.agr.HGNC:16940", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DCV3-1", "uniprot_id": "DGAT2_MOUSE", "id": "Q9DCV3-1", "name": "Diacylglycerol O-acyltransferase 2", "aln": "MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLN-RSKVEKQLQVISVLQWVLSFLVLGVA-CSVILMYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRR--SQWVRNWAVWRYFRDYFPIQLVKTHNLLTTR------------------------------------------NYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNG-----------SGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHG-ADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVP-KLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5FVP8-1", "uniprot_id": "DGAT2_RAT", "id": "Q5FVP8-1", "name": "Diacylglycerol O-acyltransferase 2", "aln": "MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLN-RSKVEKHLQVISVLQWVLSFLVLGVA-CSVILMYTFCTDCWLIAALYFTWLAFDWNTPKKGGRR--SQWVRNWAVWRYFRDYFPIQLVKTHNLLTTR------------------------------------------NYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNG-----------SGNAIVIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHG-ADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVP-KLEHPTQKDIDLYHTMYMEALVKLFDNHKTKFGLPETEVLEVN-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96PD7-1", "uniprot_id": "DGAT2_HUMAN", "id": "Q96PD7-1", "name": "Diacylglycerol O-acyltransferase 2", "aln": "MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN-RSKVEKQLQVISVLQWVLSFLVLGVA-CSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRR--SQWVRNWAVWRYFRDYFPIQLVKTHNLLTTR------------------------------------------NYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNG-----------SGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHG-ADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIP-KLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q4V9F0-1", "uniprot_id": "DGAT2_DANRE", "id": "Q4V9F0-1", "name": "Diacylglycerol O-acyltransferase 2", "aln": "MKTILAAYSGVKKG---------------------------SGSSILSALHDLPTVPWLT-RSKMVKHLQVISVLQFIMTFLTMGIA-CSLLLMYMFCTDFWVISVLYVAWLIYDWNTPGQGGRR--STWVRDWTVWKYMRDYFPIRLIKTHNLLPSR------------------------------------------NYIFGYHPHGILCFGAFCNFGTEATGFTKVFPGIKPSLATLAGNFRLPMFREYLMCGGICPVNRNSIDYLLSSNG-----------TGNAVVIVIGGAAESLDCAPGRNSVMLKKRKGFVKLALKQG-ADLVPVYSFGENEVYKQLIFEEGSWWRTIQRKLQKFLGFAPCLFHGCGLFFPESWGLVPYCKPITTVVGEPITVP-KIEEPTQDVIDMYHAMYIRSLKSLFDNYKTRFGLNESDTLIIH-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z739-1", "uniprot_id": "A1Z739_DROME", "id": "A1Z739-1", "name": "Acyltransferase", "aln": "-----------------------------------------------------MTIEWAPLRVPLERRLQTLVTSFFTYTFFTLPISSCLAVAILLYYGEMFVRSLLLIYFVKIYLDYKRNYGIMEGNGWLFYRSNWRYR-NYFPVELVKTAELPPNR------------------------------------------NYIVASFPHGILGTGTCINMSLDIDNWLSLYPHVRPKIATLDHHFKTPFLRDILRWWGMVSVSKESLSYLLSKSNDPMHKDNRDGFTSNAVAVLVGGAKEAMDSHPGQYILTLKDRKGFVKMAVRTG-SSIVPSLSFGEVDIFDQVANPPDSSLRRFQNVVKKFTGISPLLPKGRGIFN-YNYGILPHRRRIVQVVGSPIDVE-RCETPDPEYVDKIHGQVIDALARMFDEYKEKYTPNSKHIKLIIQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q08650-1", "uniprot_id": "DGAT2_YEAST", "id": "Q08650-1", "name": "Diacylglycerol O-acyltransferase 1", "aln": "---MSGTFNDIRRRKKEEGSPTAG-------ITERHENKSLSSIDKREQTLKPQLESCCPLATPFERRLQTLAVAWHTSSFVLFSIF----TLFAISTPALWVLAIPYMIYFFFDRSPATGEVVNRYSLRFRSLPIWKWYCDYFPISLIKTVNLKPTFTLSKNKRVNEKNYKIRLWPTKYSINLKSNSTIDYRNQECTGPTYLFGYHPHGIGALGAFGAFATEGCNYSKIFPGIPISLMTLVTQFHIPLYRDYLLALGISSVSRKNALRTLSKNQ--------------SICIVVGGARESLLSSTNGTQLILNKRKGFIKLAIQTGNINLVPVFAFGEVDCYNVLSTKKDSVLGKMQLWFKENFGFTIPIFYARGLFN-YDFGLLPFRAPINVVVGRPIYVEKKITNPPDDVVNHFHDLYIAELKRLYYENREKYGVPDAELKIVG-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . ::**.: . :*. : : : :: : . :. . . . . *:: :***: *:** :* .. .*:.. .**** *: :. : . :* : : ** :*: *. *: * *: .*.:.. **.. :: :::*** *:: . .. : *..****:*:*:: * .:** :*** : :. : .* .* .:: *:: : . *:* :*::*. * *** ** : : * . :: * : * :: : : :: . . : ", "identical_positions": 61, "similar_positions": 107, "identity": "13.62%" }, { "cls_id": "homologset.agr.HGNC:16941", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6R556-1", "uniprot_id": "SEGN_RAT", "id": "Q6R556-1", "name": "Secretagogin", "aln": "MDNAH-----------------------RQTQAHLDAACFWQIWQRFDKDEKGYIKETELDAFFDDLLAKFGIEDT----LMEENVQKMKEQLMVGHDISKEGRILMKELASMFLSEDENFLLFFRLETPLDNSVEFMQIWRKYDADSSGFISAAELSNFLRDLFLHHKKV--ISEAELEEYTSTMEKIFDRNKDGRLDLNDLARILALQENFLLQFKMDASSTEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQP-SISGVDLDKFREILLRHCDVNKDGKIQKSELALCLG--LKINP----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WD9-1", "uniprot_id": "SEGN_MOUSE", "id": "Q91WD9-1", "name": "Secretagogin", "aln": "MDNAR-----------------------RKTPARLDAACFWQIWQRFDKEEKGYIRETELDAFFDHLLAKSGTEDT----LMEENVQKVKEQLMTSHNVSKEGRILMKELASMFLSEDENFLLFFRLETPLDNSVEFMQIWRKYDADSSGFISAAELCNFLRDLFLHHKKN--ISEAELEEYTSTMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDASSTEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQP-SISGVDLDKFREILLRHCDVNKDGKIQKSELALCLG--LKINP----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O76038-1", "uniprot_id": "SEGN_HUMAN", "id": "O76038-1", "name": "Secretagogin", "aln": "MDSSR-----------------------EPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDT----VMKANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKA--ISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQP-SISGVDLDKFREILLRHCDVNKDGKIQKSELALCLG--LKINP----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5XJX1-1", "uniprot_id": "SEGN_DANRE", "id": "Q5XJX1-1", "name": "Secretagogin", "aln": "MDSA---------------------------FANLDAAGFLQIWQHFDADDNGYIEGKELDDFFRHMLKKLQPKDK----ITDERVQQIKKSFMSAYDATFDGRLQIEELANMILPQEENFLLIFRREAPLDNSVEFMKIWRKYDADSSGYISAAELKNFLKDLFLQHKKK--IPPNKLDEYTDAMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDASSQVERKRDFEKIFAHYDVSRTGALEGPEVDGFVKDMMELVRP-SISGGDLDKFRECLLTHCDMNKDGKIQKSELALCLG--LKHKP----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P41044-1", "uniprot_id": "CAB32_DROME", "id": "P41044-1", "name": "Calbindin-32", "aln": "MDSAAAAAAKRVQIEKAHNFMRQYRDPESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSCFMEAYDDNQDGKIDIRELA-QLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFKG-ATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTDKHGKISRKELTMILLTLAKISPDDEE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.: .*.* * ::* ::* : :***. .*** *: .:: . * : . :.::*. :* : . :*:: :.*** :*. :*****:** : **:.*****:***:**:*.**:*.* ** ***:**: . ** :. :* ***.:* ::** ******:*.::*::*.::**** : :.. : *.*:**:*: ** ..:*::*. *:.**:**::***: . .. ** *.* :: . :*.***.:.**:: * * .* ", "identical_positions": 105, "similar_positions": 100, "identity": "33.65%" }, { "cls_id": "homologset.agr.HGNC:16942", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZTI7-1", "uniprot_id": "D3ZTI7_RAT", "id": "D3ZTI7-1", "name": "Serine/threonine-protein kinase/endoribonuclease IRE2", "aln": "---MARPVQSFQLWSALGFLLQLA-IFLGKLGPQVQSVRP-------------------------------------------------------------------------------ESLLFVSTLDGSLHALNKQTGDLKWTVKDDP------IIQGPMYVTEMAFLSDPA-DGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS-------------DGVFYTGRKQDAWFVVDPESGETQMTL----------------TTEG-----FSTPQLYIGRTQYTVSMHDPRTP---TLRWNTTYRRYSAPPVD-GSPGKY-MSHLTSCGMGLLLTVDPGSGTVLWTQDLGVPVTGIYTWHQDGLRQLPHLTLAR--DTLHFLVLRWGHIRLPASSSQDTVTQFS-SLDTELLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTVQVSG-EREGSPSTAVRYPSGS-VALPSQWLLIGYHEPPPVLHTTMLRVQRTPGKGSAD---TRDSDDLHAPALSFEFLNLKREEPWDPELHPEEKA-DTYPGLGSQDLLAASFTAILLGAWVLYLMRQQQ--------QSPSAPAGPSDLP-QDTQVQLSRDTLQNQRRFQSPPEPVQPAHDP-------------EAEQPTVVGKIS---------FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFSLVQREVQLLQESDRHPNVLRYFCTEQGPQFHYIALELCQASLQEYVE-----SPDLDRW-GLGPTMVLQQMMSGLAHLHSLHIVHRDLKPGNILMAGPD--------SQGQGRVVISDFGLCKKLPAGRCSFSLHSGIP-GTEGWMAPELLQ-----------------------------LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDHCLAQLQEETHDK----VVALDLVKAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPEQGP--LVTALEAGSYKVVR-ENWYKHISAPLQEDLKRFRSYKGTSVRDLLRAMRNKKHHYRELPTEVRQTLGQLPAGFAQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPA-------------------------ALEARGSCQVPQRAETPRGPKGRPRS--------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z2E3-1", "uniprot_id": "ERN2_MOUSE", "id": "Q9Z2E3-1", "name": "Serine/threonine-protein kinase/endoribonuclease IRE2", "aln": "---MARPVQRFQLWSPLGFLLQLV-TLLGKLGPQVQSVRP-------------------------------------------------------------------------------ESLLFVSTLDGSLHALNKQTGDLKWTVKDDP------IIQGPMYVTEMAFLSDPA-DGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSS-------------DGVFYTGRKQDAWFVVDPESGETQMTL----------------TTEG-----LSTPQLFIGRTQYTVSMHDLRTP---ALRWNTTYRRYSAPLLN-GSPGKY-MSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLAR--DTLHFLVLRWGHIRLPASSYQDTATQFS-SLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSG-EREGSPSTAVRYPSGS-VALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAE---TRASEDLHAPPVFFELLNLRRE---DPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQQ--------QSPSAPAGPPDLS-QDAQGQLSRDILQDQRRFQSPSEPAQPPHDP-------------EAGQPTVVGKIS---------FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVE-----SPDLDRW-GLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPD--------SQGQGRVVISDFGLCKKLPVGRCSFSLHSGIP-GTEGWMAPELLQ-----------------------------LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDK----VVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGP--LVSALEAGSYKVVR-EDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPP-------------------------ALEAR-------RPDATKS---------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q76MJ5-1", "uniprot_id": "ERN2_HUMAN", "id": "Q76MJ5-1", "name": "Serine/threonine-protein kinase/endoribonuclease IRE2", "aln": "---MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRP-------------------------------------------------------------------------------ENLLLVSTLDGSLHALSKQTGDLKWTLRDDP------VIEGPMYVTEMAFLSDPA-DGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS-------------DGVFYTGRKQDAWFVVDPESGETQMTL----------------TTEG-----PSTPRLYIGRTQYTVTMHDPRAP---ALRWNTTYRRYSAPPMD-GSPGKY-MSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLAR--DTLHFLALRWGHIRLPASGPRDTATLFS-TLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSG-EREGSPSTAVRYPSGS-VALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAE---TRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHIS-QDAQSLHSGASRRSQKRLQSPSKQAQPLDDP-------------EAEQLTVVGKIS---------FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVE-----NPDLDRG-GLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPD--------SQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIP-GTEGWMAPELLQL----------------------------LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDK----VVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEP--LVRALEAGGCAVVR-DNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPP-------------------------DSEAR-------RPCPGATGR-------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1QQI8-1", "uniprot_id": "A0A8M1QQI8_DANRE", "id": "A0A8M1QQI8-1", "name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "aln": "---MMRMMKN---WTQMLLLLVCFAGIVSQCEGGSSVSLP-------------------------------------------------------------------------------ESLLFVSTLDGSLHAVSKQTGDIKWTLKEDP------IIQVPEYFQEPGFLPDPN-DGSLYVLGGKRKEGLMKLPFTIQELVQSSPCRSS-------------DGVLYTGKKQDTWFVVDPQTGEKQTSL----------------STSSSDSICPSAPLLYIGRTEYMITMYDTKTQ---ELRWNATYNDYSAPLYD-DKKYEYKMSHFASSGDGLVVTVDRDSGEVLWMQKFDSPVAGFYLWSQDSLRRAPHLTVAT--ETLRYLTFTAENTQSHTMKWTYQFTKESHSTKTQLVPTLYVGKTESHLYASASLVHQGVAIVPKGLTLARIEGPMTAGVTMGNGRPECEITPSTDVKYPPGSSSSLQNQWLLIGHHEIPPLAHTTMLRDFPENLQRSGD---VIPPRGSGSSYRSPSHPLPPVRKQSSSPVLPDSLSSEPMTVLVVTLLLGAWITFLLTHKWPVKKSQRSEEPVDSTPLSGLTNYSASTELN-TPPSTSSYSNSSRSEKTSSVASNQTQPFSSKDSAPVTAASQSQNEQADVVEVGKIS---------FSPAEVLGHGTEGTFVFRGHFDGRRVAVKRILPECVEFAEREVQLLRESDEHPNVIRYFCTERDRQFTYIAIELCAATLQQYVE-----DPSCPHS-ELNPVSLLEQTMCGLSHLHSLNIVHRDLKPRNILLSLPG--------ALGRVRALISDFGLCKKLPDGRHSFSLRSGIP-GTEGWIAPELLIN----------------------------APKGNPTSAVDIFSAGCVFYYVTSKGQHPFGDTLRRQANILSGVYNLDHFMEDIHED----VIGRDLIERMISAEPESRPSAASILKHPFFWSPEKQLQFFQDVSDRIEKEPTESP--IVARLENSGRSVVR-TNWRMHISAPLQADLRKFRTYKGNSVRDLLRAMRNKKHHYHELPPEVQSALGEVPDGFVAYFTSRFPRLLLHTHTALSICAPERPFHPYYHH-----------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A8JR46-1", "uniprot_id": "A8JR46_DROME", "id": "A8JR46-1", "name": "non-specific serine/threonine protein kinase", "aln": "---MRFCVVVCCVLFLLASGLIASATAKSQQGDSAEVVSSGEDEKTDCTDLA----------------------------------------------------------------RDEEALMVFSTLGGGLTAIDPVTSEIRWTIADDPPI----VAEHQENVQVPHFLPDPR-DGSIYQLG--QMGSLKKLPYTIPQLVANAPCRSS-------------DGILYSGKKSDTWYMVDPKTGRREKVMGFG--------DATVDGKEGEQIGWATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSD--EAYQAILEESKTGNVNT---------------VKLFQSLYVGEHQKGLYALPSLVDKNTPRISTAPPIKLLDGPTGDQNSNQETDPRTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNANAED----------LVDLGNGQVRVGKIS---------FSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEG----DRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPD--------AKGKVRVMISDFGLCKKLNFGKTSFSRRSGVT-GTDGWIAPEMMR-------------------------------SQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAE--PLKSLEKNGRIVVL-DDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKIGSPKKTPSPASSQAQQLKQRKGLYNFRKPNDELPIPGVGLQRNLELDGQSLEPDGKRDVFANFKFRRYSKPGNNRNYNGGHKEAQDKEKYVIWTLPPSTQD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32361-1", "uniprot_id": "IRE1_YEAST", "id": "P32361-1", "name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "aln": "MRLLRRNMLVLTLLVCVFSSIISCSIPLSSRTSRRQIVEDEVASTKKLNFNYGVDKNINSPIPAPRTTEGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISVPYLENRSLNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGNIYYFN--AHQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPGSKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIHSYDGAS-YNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLRTNENILVPHPFNPGDHESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNSLKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFKILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEKDNDDADEDDEKSLDLTTEKKK--RKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRS--LIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS----------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : . . ::. : : *.* *:. ...: *:: : : : :: :* **.:* :. .* *** :* :** :* : . * .*:* : :: .*. : . : :*:* : : ::. :. . ::. ::: * * : :.* :. :. : : . : ::.. . : . . . . : . * : : : : .: :. . : :.:*. . . .:** * **.**:* *: * *****:* : :. *: ** *** * **:**:*:* :* ***:*** .**: .* . . :* * .*::*****.*:***:** *:*:: .. . * ::********* *: ** . . . **.** ***:: * ::**** ***:**: * * *.**:. *::**: * .: . . . :*: *: * **.* : **:** * *.*: .*** :* . : :: .. *: :* ::. : :*.::* * . .: *****:*** **: :*. . :* :* * *:..***.*: .: . : : : ", "identical_positions": 162, "similar_positions": 205, "identity": "12.94%" }, { "cls_id": "homologset.agr.HGNC:16943", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CQC5-1", "uniprot_id": "BORG2_MOUSE", "id": "Q9CQC5-1", "name": "Cdc42 effector protein 3", "aln": "MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHSGQFPGHNDFFRANSTSDSMFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFHSKQESFGRPKLPRLSCEPVMEEKVQEQSSLLENGAVHQGDTSWGSSGSGSQSSQGRDSHSSSLSEQSSDWPADDMFEHPASCELVKSKTKSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UKI2-1", "uniprot_id": "BORG2_HUMAN", "id": "Q9UKI2-1", "name": "Cdc42 effector protein 3", "aln": "MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "************************************************************************** *******:**********:**********************************:******* .**************.**:*******:*************.***************** .****:***:**:.***:*.*******:******************************", "identical_positions": 235, "similar_positions": 16, "identity": "92.52%" }, { "cls_id": "homologset.agr.HGNC:16944", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96I25-1", "uniprot_id": "SPF45_HUMAN", "id": "Q96I25-1", "name": "Splicing factor 45", "aln": "MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEA-------SGFARRP-DPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGD--------------ATEK-----------------DASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC-EKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8JZX4-1", "uniprot_id": "SPF45_MOUSE", "id": "Q8JZX4-1", "name": "Splicing factor 45", "aln": "MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIADTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEA-------SGFSRRP-DPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGD--------------ATEKGE-------------AQDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEEC-EKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M2BC07-1", "uniprot_id": "A0A8M2BC07_DANRE", "id": "A0A8M2BC07-1", "name": "Splicing factor 45", "aln": "MSLYDDLGVATSDAKTEGWSKNFKLLQSQLKVKKAALTQAKTQRTRQSNVLAPVIDLKRGSGGDDRQISDTPPHIAAGMKDSSSGGFSSGDVLIPLADEYDPMFPNDYEKVLKRHREERQKQREQERQKEIEEREKKRKERHEGGGGGGAPSGFSRFPTEGESDEEEDYEREKRKRTAGGAAIAPPTSLVERDS----SFTYDEDGRQR---TKAAIPPPVFEDSDRPRSPPGPANSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIIGD--------------STEKTTGPSQNVANPDGSNSADASKKNETNPLTEILKCPTKVVLLRNMVGRGEVDEDLEAETKEEC-EKYGKVVRCVIFEISGVTDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDRFRVLDLGDQV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7PL83-1", "uniprot_id": "Q7PL83_DROME", "id": "Q7PL83-1", "name": "Splicing factor 45", "aln": "MDLYDGIDTRARSSQIDGWSSGIKMLQTQLAVKMAVK---KPLMTPVVNLRSKRLADPEVTCFAPITTVVSKPLISGKALPSILERINRGD--WDVADEYDPQRPNEYEKLKEKSNGSDKNRAGVSDREDRDDKEKDRKRGRVGR------REFYRDEVSAPNLKLSGFG----HRQNDDDMYLPSPGLVAKQG------------------GATIAPPPSLQEMSIDSG--CEATNTMPYSASSVAAKIMAKYGFKDGQGLGKSEQGMAIALQVEKTSKRGGRIIHEKDVFLPPLALSPPSIGSQIGTSPSHKAMPPPQMVDTAAESGDIGYSITEIMKSPSKVVLLRNMVGPGDVDEELEPEVKDECNTKYGEVNSVIIHESFGTVPEDAVKIFVEFRRIESAIKAVVDLNGRFFGGRQVRAGFYNYDKFKCFQLH---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.***.:.. : .:: :***..:*:**:** ** *. *. * .: : : . : * ::. . :. *: :****** **:***: :: . . :.: . ::: :::** ** : . * * . . : ..: :* .. *...** :: : *** :: . . :.. :. ..:** *** ****::****** ***:: **.*********:** . .:: *.. . .:***:*.*:********** *:***:** *.*:** ***:* :*.* *. ::**:**:**.*:*************:**** *:* *** *:*: ::* ", "identical_positions": 139, "similar_positions": 114, "identity": "31.52%" }, { "cls_id": "homologset.agr.HGNC:16945", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VE62-1", "uniprot_id": "PAIP1_MOUSE", "id": "Q8VE62-1", "name": "Polyadenylate-binding protein-interacting protein 1", "aln": "MSDSFDRAP------------------------------------------------------------------------------------------------------------------------------EQTKPQRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSANAPEFYPSGYSSNYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGWVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEAKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDTWKEKGKTDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JVP5-1", "uniprot_id": "A0A0G2JVP5_RAT", "id": "A0A0G2JVP5-1", "name": "Polyadenylate-binding protein-interacting protein 1", "aln": "MSDSFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERSQHQPPPQPKAPGFLQPPPLRQPRTAPPPGAQSEAPAGSARPPRPGALPGTEQLEGPRCSWASFPPRAFAHAELRRAESAPRFSESIPRGARSAREQTRPQRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSANAPEFYPSGYSSNYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGWVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEAKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDTWKEKGKTDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H074-1", "uniprot_id": "PAIP1_HUMAN", "id": "Q9H074-1", "name": "Polyadenylate-binding protein-interacting protein 1", "aln": "MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPP-QPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALP----------------------------------------------EQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***.***** ***:* ***********************************.************.********************************************** *************************************************************.********************************************************************************:****** *******************************************************************************************************************************************", "identical_positions": 391, "similar_positions": 6, "identity": "74.33%" }, { "cls_id": "homologset.agr.HGNC:16946", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K2B0-1", "uniprot_id": "SC65_MOUSE", "id": "Q8K2B0-1", "name": "Endoplasmic reticulum protein SC65", "aln": "-MARGAWGLLWLLLGSAG----AQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPASGPDGDHDGDGEDWARELRLFGHVLERAACLRRCKKTLPAFQVPYPPRQLLRDFQSRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALAEYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCETNLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEDEDFQPREEAMLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEEPLSDAEFEGEGDYEEGLYADWWQEPEAKGDEAEAEPEPELT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q64375-1", "uniprot_id": "SC65_RAT", "id": "Q64375-1", "name": "Endoplasmic reticulum protein SC65", "aln": "-MARAAWGLLWLLLGSAG----AQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPAPGPDGDNEGDGEDWARELRLFGHVLERAACLRRCKRTLPAFQVPYPSRQLLRDFQNRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLQAVKLYNSGDFRSSTEHMERALADYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVHQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAVLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEKPLSDAEFEGEGDYEEGLYADWWQEPDAKGDEDEAEPEPELA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q92791-1", "uniprot_id": "SC65_HUMAN", "id": "Q92791-1", "name": "Endoplasmic reticulum protein SC65", "aln": "-MARVAWGLLWLLLGSAG----AQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPAAK---PDPDG---GRADEWACELRLFGRVLERAACLRRCKRTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALSEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAMLYHNQTAELRELLEFTHMYLQSDDEMELEETEPPLEPEDALSDAEFEGEGDYEEGMYADWWQEPDAKGDEAEAEPEPELA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4INE3-1", "uniprot_id": "A0A0R4INE3_DANRE", "id": "A0A0R4INE3-1", "name": "", "aln": "MVDTKTYFFVFLSIAYSSSFVKAQYEKYSFKSFPMNDLMPLESAYGHALEMYATQDWKQSLTYLELSLRLHRLLRDSEAFCSSNCSTVCSEYE-------------NNSTGTTFRIMEHIILRAACLKRCKTKFPVFSKSYPKRETLAAFEKRIPYRYLQFVYYQMNELERAVSAAHTYLQRNPGDPLLSRSVNYYKSLFDL-EEYLIDHEEKSYEALFLKAVKLYNSGDFSSSVRDMELTAAEYFTKYQMCLLSCEGSYDVQEFKDFYPALAELYFEVLQCKVKCEENLMPNVGGYFVDKFVATMFHYMQFAYFKLNDVRNAALCAATYMLFDRDDQVMQQNMAYYRFYREQWGLQDEHFKPRPEALKYYNLITKLRELLEFANNYLQTDDEDSVSADEAVLSNP---ADEEFEGIGDYEESFLAEWWQEPKTKGDTGEPVE-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: :::* :. :. ********:.** :***** :******* * :.*::* *** :************** :*** .. :. . :*:: ::: *****:*** .:*.*. .** *: * *:.*:**:**::. :: *.**:**:**:*:***** . * :: :***:.::*: :* * * * :.***:**:********** **...** : ::*:: : ** .***::: :*******:*:*: * *****.** ** *****:*********:**:****:*****::** .**:***** .*.*****:.****:* :***::*.*:** **: *:* ::*****:*:: ***:*** .:. *. . :* **** *****.: *:*****.:*** *. ", "identical_positions": 222, "similar_positions": 122, "identity": "49.55%" }, { "cls_id": "homologset.agr.HGNC:16947", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1WBY7-1", "uniprot_id": "B1WBY7_RAT", "id": "B1WBY7-1", "name": "Erlin-1", "aln": "MLCARPSQFCPARAPSSGRGLRRVRPRAAAVSDRWAGPAVGSSWRGRVAAARAGGGDASLTGGTRMNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDVRTEREGSLSPEETHEPSGESPIQNKENAG-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91X78-1", "uniprot_id": "ERLN1_MOUSE", "id": "Q91X78-1", "name": "Erlin-1", "aln": "-----------------------------------------------------------------MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPSMFVDSSCALKYSDGRTGREDSLPPEEAREPSGESPIQNKENAG-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75477-1", "uniprot_id": "ERLN1_HUMAN", "id": "O75477-1", "name": "Erlin-1", "aln": "-----------------------------------------------------------------MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q58EG2-1", "uniprot_id": "ERLN1_DANRE", "id": "Q58EG2-1", "name": "Erlin-1", "aln": "-------------------------------------------------------------------MAHVGAVVAAMAGLMAILLHSSIHKIEEGHLAVYYRGGALLTSPNGPGYHIMLPFITSYRSVQTTLQTDEIKNVPCGTSGGVMIYFDRIEVVNMLIPTSVVDIVRNYTADYDKTLIFNKIHHELNQFCSVHTLQEVYIELFDIIDENLKTALQKDLNCMAPGLTIQAVRVTKPKIPEAIRRNYELMEAEKTRLLITVQTQKVVEKEAETERKKAIIEAQKVAQVAEIQFQQKVMEKETEKKISEIEDAAFLAREKARADAEYYTAAKFAEANTLKLTPEYLQLMKYQAIAANSKIYFGQDIPNMFVDSSASRPAAG-ESEQLESLSMRESLKKASKP----KASEGH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::. :***:.**:*:**::***********************.************::***********:**************:********* * :*.****************************.************ ****** ******* ************************:********:***:.*.*************:*:***:*:****:*:************:***************:******:* *:* :*. *******:* ******:*******.:**.******.: :. .: : **. .*: : :.: * . * ", "identical_positions": 263, "similar_positions": 55, "identity": "63.53%" }, { "cls_id": "homologset.agr.HGNC:16948", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CPT4-1", "uniprot_id": "MYDGF_MOUSE", "id": "Q9CPT4-1", "name": "Myeloid-derived growth factor", "aln": "MAAPSGGF-------WTAVVLAAAALKLAAAVSEPTTVPFDVRPGGVVHSFSQDVGPGNKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTIWRPQGKSYLYFTQFKAELRGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAARSEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZTQ0-1", "uniprot_id": "A0A8I5ZTQ0_RAT", "id": "A0A8I5ZTQ0-1", "name": "", "aln": "MAAPSSGF-------WTALVLAAAALKLAAAVSEPTTVPFDVRPGGVVHSFSQDIGPGGKFTCTFTYASQGGTNEQWQMSLGTSEDSQHFTCTVWRPQGKSYLYFTQFKAELQGAEIEYAMAYSKAAFERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAAHSEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q969H8-1", "uniprot_id": "MYDGF_HUMAN", "id": "Q969H8-1", "name": "Myeloid-derived growth factor", "aln": "MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****.*: *:*::*.*.**: * ********.*************:::***.*:** ********************** ******:*****************::************************:**********:*******************:::**", "identical_positions": 140, "similar_positions": 22, "identity": "80.92%" }, { "cls_id": "homologset.agr.HGNC:16949", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C3F2-1", "uniprot_id": "F120C_MOUSE", "id": "Q8C3F2-1", "name": "Constitutive coactivator of PPAR-gamma-like protein 2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRITRGSAPLPPPPLPPAAFGAYSGGAGPSRHHHPAHHFHHHGQAPPGLHP----PPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPS---FLGFRNNRLGNPPLPRNQMGPISPGKPMFSRQVPQKMKYPPP---FPMGPNSSLLFS-HSVGESHAFSEDAMLQDNSFANWAVSYDSN--TSQFPNCLTSKTSPPLGPDSSHSSSSDGDEANGAGSEQITEAVQQQPGWEDPNGDRGAWGQPADAGVSETTVAESEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAIRRRLPMEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPS-ALLPSPTFVPP-MVPSLYPVS-LYS-RAMGSFPPPP-----QARSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRSRGSFGMQVVSVGGPGKGHGKEQAGRGSKGHKKGNKQ--GSSDVISKAVELHQ------------SRARSQVNGNN-GTLIVEEKSDP-LPAPSQCALSRDSNECNNSDDHCLPVKNGEKNHVPEQELEAVAQQKEE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6A052-1", "uniprot_id": "A0A8I6A052_RAT", "id": "A0A8I6A052-1", "name": "", "aln": "MLIRPAPAPLPQLESEYHREDEATWLPEVEGRGFTPFEEVKKSSGGEREKRSDYDLSSLLSSQPLLSLVSLTSALHPHPVCGLLPSPPTFPRPSRSRTLSPPPSPLPPAECARARLQLRAGIAAWLACAAAVSSAHGGSMGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPP-AALAPGAPRIARGSAPLPPP-LPPAAFGAYSGGAGPTRHHHPAHHFHHHGQAPPGLHP----PPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPS---FLGFRNNRLGNPPLPRNQMGPISPGKPMFSRQMPQKMKYPPP---FPMGPNSSLLFS-HSVGESHAFSEDAMLQDSSFANWAVSYDSN--TSQFPNCLTSKTSPPLGPDSSHSSSSDGDEANGAGSEQVTEAVQQQPGWEDPSGDRGAWVQPVDAGASETNATESEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAIRRRLPIEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPS-ALLPSPTFVPP-MVPSLYPVS-LYS-RAMGSFPPPP-----QARSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRSRGSFGMQVVSVGGPGKGHGKEQAGRGSKGHKKGNKQ--GSSDGISKSVELHP------------SRARSQVNGNN-GTLIVEEKSDP-LPAPPQCALSRDSTVCNSSDDHCLPVKNGEKNHVQEQELEAVAQQKEE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NX05-1", "uniprot_id": "F120C_HUMAN", "id": "Q9NX05-1", "name": "Constitutive coactivator of PPAR-gamma-like protein 2", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPTAALAPGAPRAARGSVPLQPP-LPPAALGAYSGGAGPTRHHHPAHHFHHHGQAQPGLHPPLPPPPPPQLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPS---FLGFRNNRLGNPPLPRNQVGTISAGKPMFSHQVPQKVKYPPP---FPVGPNSSLLFSSHALGESHAFSEDPMLQNSPFANWAVSYDSS--ASQFPNYLPSKASPPLGPDSSHSSSSDGDEPNGASSDHITEAFHHQPEWGNPNRDRGSWAQPVDTGVSEASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAMRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDRLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPS-ALLPSPTFVPP-MVPSLYPVS-LYS-RAMGSMPLPP-----QGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGSKGHKKGNKQ--GSSDGVSKSLELHQ------------GRSRSQVNGNS-GALIKEEKSDHRLPAPSQCALSRDSNECNNGN-RYLPMNNREKNHLQEQKLETVAQRKED", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QJ40-1", "uniprot_id": "E9QJ40_DANRE", "id": "E9QJ40-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------MGVQGFQEYLEKRCPGAAVPVDLLKLARTAGRQPP-------------------------------------------------HHHPHHHHHPH--HPSSLPP----PPPP----ARILVDADSGLQRLYGGYQTDWVCGGEWNAMLGYLAALSQACLYQGG--LELVVVFNGTLGKDRWPEWARRAQGQRQTAQLIVNHVGSKATPPPRAWFLPPACLSHCVRLAMFRFRVRVVQTLEDHHQEVLSLYRDYGFQGLIAQDSEFALCNVPAYFSSHALKLSWNGKNLTTHQYLLSEAARQLGLKTQHLPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCEVVIKAVSEYVASIKDLGNLDSVAKDVFKQSQSRTEDKIERFKKAVEYFSAASKPRPLSMGPSPYLFPGFGPSPFAGPPG---HVGAVQPLKAQFGPPQVSGVKVPYPGGLYGPGPATGPALLCQNPTQPLQDCNDSLVGKMGFADWSAPYDSSQGGSRQPN---HHTAAPTGPSPSSSSSSDGEEQNDTSANHLADKSTR---WEDPSGRSGSGSGDGHHGN------GSGPSIPSLLSMPTRSHMDITTPPLPQVSAEVLRVAEHRHRRGLMYPQIYHILTKGEMKMPVCIEDECNPDLPPASLLFRSARQYAYGVLFSLAETQRRLERLAMRKRSPVDVPPVIVKEWCASKAKSALTPELVPALCFREWTCPNLRRLWLGRASEDRSRRTRAFLACMRSDCPALLNPTCVPSHLLLMCCVLRYMMQWPGGRILQRHELDAFLAQAVSNQLYEPDQLQELKVEKVDNRGVQLASLFMSGVDTALFVNDVCGQPLPWDHCCPWGFFDGKLFQSKLAKATRDRASLLDMCEGQEELVSRVEKMRQAILEGINLSRPPPPPPPLPPPAFLPPAMVPPFYPMHPLYPPRPLGSMPPPPPHHHHQHRPRAFPGIQSIPPQGGKLEIAGMVVGQWAGNKPIRGKGGFNMQVVSVGGKGRGKDLTVKGRGGKKVITNRTQTLSSSPPSSSPPKLMEDTKSVGRPAEGTGPASQQLNGSSSGSATGQALDLPPLAQPIQCALASRDNQSGDGVEVEAPC-------CLDDCPSDGALQKEE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ********:********.***********..** **** **.* * ..* * **** **:****.*.* **************:********:**.*** * ** *****:* * ***** .**.**.*.:********.***.*.*********************::****:*.*:***** **::::*: **:**:*:***:** *:*:*:****************:*:*:.*.*:***** ::**********************************************:**********:**** .*** *.************************:*.::* .*.:*** * ** . :..** ::*.:.. *. *. . :* * * : ** :. : : :. .:*.:: . **:*:..***. *: ** :::.* **..* ******:* *.:.:::::: : * :*. *: . * . * *******.**.***** **** *:.***************** ***:*****:*:********* :****:*********.************::****:*:* *::**.**:***.* *.**. *****.** *********::****:* **:.** *******:** *::***: **:************:********:*****:*******.******:*****:**:* **:***:***********.**.****:**:***** :********** ** *:*.**:::*:** :*.::******:****:*:.:***. . **.*:*:** ***.:**: **. *.:**:* ** * *.*.*.*::.********************.:. *.:*.*.******** *:*:. ***.* ....* .** *.. :* . : .*:**.. *: : . *. * ****: .. .... * :: . * :**:", "identical_positions": 643, "similar_positions": 233, "identity": "50.67%" }, { "cls_id": "homologset.agr.HGNC:1695", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P50283-1", "uniprot_id": "CD7_MOUSE", "id": "P50283-1", "name": "T-cell antigen CD7", "aln": "MTQ---QAVLALLLTLAGILPGPLDAQDVHQSPRLTIASEGDSVNITCSTRGHLEGILMKKIWPQAYNVIYFEDRQEPTVDRTFSGRINFSGSQKNLTITISSLQLADTGDYTCEAVRKVSARGLFTTVVVKEKSSQEAYRSQEP------------------LQTSFSFP---------AAIAVGFFFTGLLLGVVCSMLRKIQIKKLCASGIKE-SPCVVYEDMSYSNRKTPCIPNQYQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B2RZ54-1", "uniprot_id": "B2RZ54_RAT", "id": "B2RZ54-1", "name": "", "aln": "MT----QALLALLLTLARILPGPLDAQEVHQSPRVVIASEGESINITCSTRGDLEGLIMKRIWPQASNVIYFEDELEPTVDSAFSGRINFSGSQKNLTIIMSLLQEADTGAYTCEAVRKVSVHGLFTTVVVKEKLSHEAYRSQEP------------------LQTSVSLP---------AAIAVSFFLTGLILGVLCSMLRKTQIKKLCASGNKD-SLCVVYEDMSCSNRKIPCTPNQYQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P09564-1", "uniprot_id": "CD7_HUMAN", "id": "P09564-1", "name": "T-cell antigen CD7", "aln": "MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALPAALAVISFLLGLGLGVAC-VLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: :*.***:** ***.* **:*:***: . .. * *:****** * *.*: :::: **. ::**:** **.* * ***:*****.**** : ** :*** ***:*: :*.. * * *:*.*: *: :*..:. **: ::* **:** *: ** *** * :* : ******: *: : ******** *. : . *****", "identical_positions": 103, "similar_positions": 54, "identity": "42.74%" }, { "cls_id": "homologset.agr.HGNC:16950", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6TH47-1", "uniprot_id": "STBPA_DANRE", "id": "Q6TH47-1", "name": "STAM-binding protein-like A", "aln": "----MSEHTDCSVSSEDRVRALTKLGSSVDVSEDVPPRRYFRSGMEIIRMANIYADEGNVEHAFILYNKYITLFIEKLPKHREYKTANIPEKKETMRKLKEIAFPKAEELKKLLLKQYDKEHAEYLVRKRAEDAARAVEMLKQQEQEAQRQRLAELQQRQREQEQFSAFEEMIRRQELEKERRRIVQEFSIPVSPTA--PDVLLPDVHGP----PQASLSPQTPPAGATNHQG-----LPAFDRSLKPSVPVSAGHSALVNGLRQLFVPAELCQRFLKLAETNTARAVETCGILCGKLMKNAFTVTHVIVPKQCGGPDYCDTENEEELFLIQDQNDLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFNETGYFRLT-DYGMDDVGTCKQRGFHPHPKDPPLFAASHHVSIT-DGSVTMLDLR-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32U1I5-1", "uniprot_id": "A0AB32U1I5_DANRE", "id": "A0AB32U1I5-1", "name": "", "aln": "---MMLDHADVSLSPEERVRALTKKGGAVEMNESVPLRRYFRSGMEMIRMAHVYAEEGNTEHAFVLYNKYITLFIEKLPKHPEYKLSNIPEKKEILRKLKDTAFPQAEQLKKLLLRRYEREHADYISKKRVEAEAVERELSRQRELDAERRRVAELQRRQQEQEQFSIFEEMIQQQ----ERHRHPHTHHTPAAPQT--DTPLIPGIQGPPVPFPESPTPPQSPQQPSANHSTPSAPAPPTFDRSLKPSH---LSKTTLIDGLRQIAVPAELCGKFLRLANNNTIRAVETCGILCGTLNRNAFTVTHVVVPKQCGGPDYCDTENEEELFLVQDQYNLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFNQTGYFRLT-DYGMEEISTCAQKGFHPHPKDPPLFTGGSHIIIT-EDTVSMLDLR-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8R424-1", "uniprot_id": "STABP_RAT", "id": "Q8R424-1", "name": "STAM-binding protein", "aln": "----MSDHADVSLPPQDRVRILSQLGSAVELNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKNVAFPKAEELKTELLKRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEKMIQKQELEKERLKIVQEFG-KVDPGP--CGPLLPDLEKPC--VDVAPSSPFSPTQTSDCNTTLRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLT-DYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVK-DRIVTITDLR-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQ26-1", "uniprot_id": "STABP_MOUSE", "id": "Q9CQ26-1", "name": "STAM-binding protein", "aln": "----MSDHGDVSLPPQDRVRILSQLGSAVELNEDIPPRRYYRSGVEIIRMASVYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKSVAFPKAEELKTELLRRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEEMIQRQELEKERLKIVQEFG-KVDPGP--CGPLLPDLEKPC--VDVAPSSPFSPTQTPDCNTGMRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLT-DYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVK-DRIVTITDLR-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95630-1", "uniprot_id": "STABP_HUMAN", "id": "O95630-1", "name": "STAM-binding protein", "aln": "----MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFG-KVDPGL--GGPLVPDLEKPS--LDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLT-DHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVV-DRAVTITDLR-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VA71-1", "uniprot_id": "Q9VA71_DROME", "id": "Q9VA71-1", "name": "MPN domain-containing protein", "aln": "MSKAVNNMSMGDVEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEKIRQHPDYG-SVKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAER---VKELERERERERERQ-----RQKEREKAGSSAIPSLIPAN-----LHVLIDEGNQPSAPDLGLLDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKPSYN--RTDSLLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLRR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .: .::*:: *:: *. :::.:.:* **:*** *::*** :* *** *:**:** :*:******: :* :* : .* :: :*:*. :* :*:*: ** :* :*: :: *. * :: ::* : ::: :::: *: : .:* : . * :: . * . . * .**. **. .** : ** **:** ** : :****:*.* * :* : :**:: *:* . .* *.* :**::* :**: *:***************************:*:**::****:**:: **:* ** .:*:: :. * * ***** .***** *: : : :.: *** ", "identical_positions": 142, "similar_positions": 116, "identity": "32.57%" }, { "cls_id": "homologset.agr.HGNC:16951", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2QC03-1", "uniprot_id": "A0A0G2QC03_RAT", "id": "A0A0G2QC03-1", "name": "", "aln": "MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG-VSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISGSSTGCLSSPNASVQSPKHEWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQ-PDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPSIDDWTPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q920Q8-1", "uniprot_id": "NS1BP_MOUSE", "id": "Q920Q8-1", "name": "Influenza virus NS1A-binding protein homolog", "aln": "MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG-VSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISGSSTGCLSSPNASMQSPKHEWKIVASEKTSNNTYLCLAVLDSTFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQ-PDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPNIDDWTPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNPQSNEWSPYTKIFQF-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y6Y0-1", "uniprot_id": "NS1BP_HUMAN", "id": "Q9Y6Y0-1", "name": "Influenza virus NS1A-binding protein", "aln": "MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG-ISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQ-QDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5RG82-1", "uniprot_id": "NS1BA_DANRE", "id": "Q5RG82-1", "name": "Influenza virus NS1A-binding protein homolog A", "aln": "MIPNGYLIFEDESFLDSTVAKMNALRKNGQFCDVRLQVCGHELMAHRAVLACCSPYLFEIFNSDLEPHG-ISHVKFEDLDPEAVEILLNYAYTAQLKADKELVKEVYSAAKRLKMDRVKQICGDYLLSKMDSQSAISYRNFASCMGDGRLLGKIDSYIQEHLLEVSEQEDFLKLPRLKLEVMLEDNLTLPSNGKLYSKVIGWVQRSLWENGEPLERLMEEVQTLYYSADHKLLDGSLLDGQAEVFGTEDDHIQFVQKKPPRENVHRQLSTSSSGSLSPG-STKHPCKQEWKYIASEKTTNNTYLCLAVLNGMLCVIFLHGRSSPQASPSATPCLTKSLSFEGQPLEEEPDKLLSPMHYARSGLGIASLNDQLIAAGGYNREECLRTVECYNIKTNSWTFIAPMRTPRARFQMAVLMGQLYVMGGSNGHSDELSCGETYNPNADEWTQVPELRTNRCNAGVCSLNNKLYVVGGSDPCGQKGLKNCDVFDPISKAWTNCAPLNIRRHQAAVCELDGFMYVIGGAESWNCLNSVERYNPENNTWTLIASMNIARRGAGVAVYEGKLFVVGGFDGSHALRCVEMYDPVRNEWRMLGSMNSPRSNAGAAVLNDVIYAIGGFDGNDFLNSVEAYNPKTEEWSTCADAFTDS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7ZVQ8-1", "uniprot_id": "NS1BB_DANRE", "id": "Q7ZVQ8-1", "name": "Influenza virus NS1A-binding protein homolog B", "aln": "MTPNGYLIFEDESFLDSTVAKMNALRKSGQFCDVRLLVCGHELMAHKAVLACCSPYLFEIFNADTEPQGGVSLVKFDDLNPDAMEVLLNYAYTAQLKADKSLVSDVYSAAKKLKLERVKQICGEYLLSKMDSQSAISYRNFASSMADGRLLGKIDGYIQDHLHEISEQDDFLKLPRLKLEVMLEDNLNLPGNGKLYSKVISWVQRSLWKNGDPLEKLMEEVQTLYYSADHKLHDGSLLEGQAEVCSTEDDHIQFVQKKPPRE--RDEMGSGASGSISP--SNSQFNKHEWKYIASEKTTSNSYLCLAVLRGLLCVISLHGRTSPHNSPSATPCVLKSPNFEAQ-LEDLQEKLLKPMHYARSGLGTAELDCKLIAAGGYNREECLRTVECYDPKKDCWTFIAPMRTPRARFQMAVLMGEVYVMGGSNGHSDELSCGEMYNPRADEWIQVPELRTNRCNAGVCSLQNKLFVVGGSDPCGQKGLKNCDSFDPVTKMWTSCAPLNIKRHQAAVCELSGYMYVIGGAESWNCLNSVERYNPENNTWTLVASMNVARRGAGVAVYEGKLFVVGGFDGSHALRCVEVYDPATNEWRMLGSMTSARSNAGLAVLNNVLCAVGGFDGNEFLNSMEVYNLEKNEWSPFIEALGKN", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *****:****.*::*:***:*****.******** *****::**:***************:* :*:* :* **::**:*:*:*:**************.**.:******:**::****:**:****:** *.********.*.*.***.*:*.***:** ::**:::****************: **.*****:***.*****:*:**:.**.**************** **. *:***** .::************** : ::. .::*.:*. :. : *:*** :*****:.*:******* . :*** ****.**: **::** : ** .** * :: :* :.**:******* *.:: :*******************: :.: *:*:*****************::**:********:***** *:. *:* **************:*:.**::****** ********* ***::* **.******:***:*****.*::*:***********:*************:*.**:********* :***** ********: ***:***. ***:*:*.*.*.***** :.:.:.: *:******:***::*.** :.:***. . : ", "identical_positions": 435, "similar_positions": 150, "identity": "67.44%" }, { "cls_id": "homologset.agr.HGNC:16952", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q02805-1", "uniprot_id": "ROD1_YEAST", "id": "Q02805-1", "name": "Protein ROD1", "aln": "-------------------------------------------------------MFSSSSRPSKEPLLFDIRLRNLDNDVLLIKGPPD---EASSVLLSGT------------IVLSITEPIQIKSLALRLFGRLRLNIPT-----------------------------VLQTVHGPHKR--------------YSKFERNIYSHFWDD--------------------FNIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTAS--------------------------------LISSNGQTSASKNY------------------------------HTLVKGNYEFPFSAIIPG--SLVESVEGLPNAAVTYALEATI------ERPK-QPDLICKKHLRVIRTLAID------------------------------------------AVELSETVSVDNSWPEKVDYTISIPTKA--IAIGSSTMINILIVPILKG-----------------LKLGPVRISLVENSQYCGS------------------------------YGGVINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQDK-WEVRALLNIPASLTKCSQDCRILSNIKVRHKIKFTISLLNPDG-HI------------------------SELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSYQVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTMVTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSA---VESQAIHNIQNLYISDSNNSNNPILAPNPQIKIEDDSLNNCDSRGDSVNNSNLN------------LVNSNLTISEN-----WNNNSPSANRYNNIINAG-------------LNSPSLTPSFAHLSRRNSYSRQTSS--TSLKNDLELTDLSRVPSYDKAMKSDMIGEDLPPAYPEEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNL------------KRSSSRTHLSHSPLPRNNSGSSVSLQQLARNN---------------TDSSFNLNLSFTSAKSSTGSRHFPFNMTTSFTSN------SSSKNNSHFDKTDSTSDANKPREEENYTSATHNRRSRSSSVRS------NNSNSPLRQGTGSFANLMEMFTK----RDRS--------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P43602-1", "uniprot_id": "ROG3_YEAST", "id": "P43602-1", "name": "Protein ROG3", "aln": "------------------------------------------------------MGFSSGKSTKKKPLLFDIRLKNVDNDVILLKGPPN---EAPSVLLSGC------------IVLSINEPMQIKSISLRLYGKIQIDVPLERP-----------------------QDASSSSLSSSPPK--------------IRKYNKVFYNYAWDN--------------------VNLKEYLSGLRGQSG---LAGSSSSSN---ILGTRQRAQSTSS--------------------------------LKSLKGSSSPSS--------------------------------CTLDKGNYDFPFSAILPG--SLPESVESLPNCFVTYSMESVI------ERSKNYSDLICRKNIRVLRTISPA------------------------------------------AVELSETVCVDNSWPDKVDYSISVPNKA--VAIGSATPINISIVPLSKG-----------------LKLGSIKVVLFENYQYCDP------------------------------FPPVISENRQVTELNLEDPLNESSGEFNGN--GCFVNNPFFQPDHSFQDK-WEIDTILQIPNSLSNCVQDCDVRSNIKVRHKLKFFIILINPDG-HK------------------------SELRASLPIQLFISPFVALSIKP-----LSSSNLYSLFSTTNQKD-----ENSSQEEEEEYLFSRSASVTGLELLADMRSGGSVPT---------------ISDLMTPPNYEMHVYDRLYSGSFTRTAVETSGTCTP---LGSECST------VEDQQQDLEDLRIRLTKIRNQRDNLGLPPSASSAAASRSLSP-----------LLNVPAPEDGT-----ERILPQSALGPNSGSVPG-------------VHS-NVSPVLLSRSPAPSVSAHEVLPVPSGLNYPETQNLNKVPSYGKAMKYDIIGEDLPPSYPCAIQNVQPRK------PSRVHSRNSSTTL--------------------------SSSIPTSFHSSSFMSSTASPISIINGSRS-------------------------------SSSGVSLNTLNELTSKTSN------NPS----------------------------------SNSMK----------RSPTRRRATSLAGFMGGFLS----KGNKR-------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P47029-1", "uniprot_id": "ALY2_YEAST", "id": "P47029-1", "name": "Arrestin-related trafficking adapter 3", "aln": "-------------------------------------MPMDQSISSPLFPMEKDIDIPLDATPLAQSSSLQLFIHLAEPVVFLQGFDPQ-KTEYPSVVLRGC------------LVVRILKPTKLKSISLSFKGYSRTEWPEGIPPKRQEFVEIKDIVDHTWALYPPTEQKSKKKMDASAPNESNN----AANNFLTKESGASLYRTLSDNE----------TITSRKNSISGLSSLNLSPLGAPGNSSVNVKDRESRQRSRSSSVTSSNGPSRNLSPINLLKRATSPSVSHHNYKPTTTSIFSDLLNNTFTHNDAASHHGHHIPTSSNHLAMTSNNFTS----GSGGEFFVFQPGDYIYAFEELIPQ--AYPESIKADFGFVEYFLFASIE------RPGAFKSNISARQVVNIVRTQAHN------------------------------------------SVEESEPIIISRDWENQLYYDIVIASKD--IILDAFLPITFKFAPLDK------------------VTLHRIRIYVTETMEYYCR---------------------------EKKVHRMEPTKKFLLTEQKGPKLPNLPNDANLSKAKNMGNLLQDPKNGDLVNKEYEYQIFIPSRFNNHQQLHPDTSYENIKANHWIKICLRLSRVVDNKR------------------------KHYEISIDSPIHVLHRLCSHANT------LLPSYDGHPASFPKETDSSISSILESSDDNINLYHNSNIFFPKEVLSSPVLSPNVQP----------------LDILIP-HLPSTSLTRNSRQFNRN---SKSHPSDN---TIFNSAKLKSNIYQPESLQRELASPQAIPLSPITSPMSN----MEVPPPDFDFSSDFISDAASGTTTTEVSSSESSI-----LPRDPPSYKDTVLHDNNQKRRPNSKHPTPPSLKASHPNKNSDKNSSETLNK-KESMSKIEENKHKRETTPKKRENRDVKSLSTPQREESKDSTSTGNQSNEKNRKRVLSLSSSLHSSPNNSGFAHSALGNLSNESLRSLNRRESVQDNLPSTIRHDNPFFTDLNQVLIEDELKNHDKNELNRHSTNTSSTPASARSSFDYSGINISKDKLNMEPLLSKTETLTNKVNEDSFLRPNDSYVDLLEPSVDTTIDITAPYARNSSAWHPLQNDNDNNQFSPLLGSNENFLNAANAQNSAESDHNNDIFTQGSGLTESSKNSDSEERFISRLSSPEKVLINTLDNESGLQSINESTL", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P36117-1", "uniprot_id": "ALY1_YEAST", "id": "P36117-1", "name": "Arrestin-related trafficking adapter 6", "aln": "----------------------------------MLQFNTENDTVAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEIAPSILRGS------------LIVRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQADDGMNSFTLEHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAE-------------PPKDNSNLSLDAYERNSLSSDNLSNKPVSSDVSHDDSKLLAIQKTPLPSS--------SRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGATPSP----EQEDNYLTPSKD----------SKEVFIFRPGDYIYTFEQPISQ--SYPESIKANFGSVEYKLSIDIE------RFGAFKSTIHTQLPIKVVRLPSDG------------------------------------------SVEETEAIAISKDWKDLLHYDVVIFSKE--IVLNAFLPIDFHFAPLDK------------------VTLHRIRIYLTESMEYTCNSN-----------------------GNHEKARRLEPTKKFLLAEHNGPKLPHIPAGSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKICLRLSKKYGDNR------------------------KHFEISIDSPIHILNQLCSHANT------LLPSYESHFQYCDEDGNFAP----AADQQNYASHHDSNIFFPKEVLSSPVLSPNVQK----------------MNIRIPSDLPVVRNRAESVKKSKSDNTSKKNDQSS---NVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSPPPDFDFD------------LAKRGAADSHA-----IPVDPPSYFDVLKADG---------------IELPYYDTSSSKIPELKLNKSRETLASIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSAPSENVNSHTPILQSLNMSLDGRKKNRASLHATS-------------------VLPSTIRQNNQHFNDINQMLGSSDEDAFPKS-----------------QSLNFN---------KKLPILKINDNVIQSNSN------SNNRVDNPEDTVDSSVDITAFYDPRMSSDSKFDWEVSKNHVDP----------AAYSVNVASENRVLDDFKK--AFREKRK-------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9I7K8-1", "uniprot_id": "Q9I7K8_DROME", "id": "Q9I7K8-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "------------------------------------------------------------------MVICEIEFCNNSQGIFYAG-----------QLISGQ------------VVIKTEKEKSVKAVILNIKGYAETHWADTEHDPDDQSNGE---------------------------------------------------------------------------SFNGHVDYLATRAYLHGS------SSSIE--------------------------------------------------------------------------------------------VLIEPGTSSYRFACQLPI--TCPSSFEGTLGRIRYLVNVRFV------RPWKFDLNFNRCFTVIKVMDLNSES----------------------------------LMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSG--FVPGQIVPVEVMVSNDSG------------------VAVEDITVKLTMVVIYYSQ------------------------------------------------PPSA-DTNKDRFEMVLKTGGGVSTKCRQQFTFDLKVPPTPPTCFNL---------CSIIQIGYQVEAEARVKGCHG----------------------------GQSLHMPITIGSVPLT-KQLQKE------------PRTWGEVLPPQQLDAKALILIGSEQNGEALGSPNPWAADP----------------------------SIAPPSYAEAKHISPDPHKFSKSKKKSQKRGVKGSQERKAETIVFSPLYAVFDLSNQVDEMTLRANEPKTDG-----GYVNEGVEKSTWL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A8JQV1-1", "uniprot_id": "A8JQV1_DROME", "id": "A8JQV1-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "-----------------------------------------------------------------MGIICQILFHNNTQGVFYAG-----------QMVAGQ------------VTLSTDKAIQIKAIRLKLKGYAETHWTESKTDSNNKSTSE---------------------------------------------------------------------------SYNGFEKYLSSKVYLLGS------EISPE--------------------------------------------------------------------------------------------MALEPGTRSYNFACPIPI--NCPSSFEGTHGRIRYMVDVNII------QPWKYDSIFSRAFTVIQVMDINTYN----------------------------------SVSQVPVQAKTEKTFGVWPFRSDPLTLELNLPQTG--FVPGQTVPANVLIGNESK------------------IRVHEVKVGLSMMITYYSD------------------------------------------------LSSG-SKCERKSVAKLKADG-VLRNSRKMYDFQLMIPSTPPSCFHL---------CRIIKIGYQIEVVAKVKGMHI----------------------------NGTLIMPVTICGVPISPSAVQYT------------PQSSGPEAPEQ----RALTLIEGEGAFAPAAPPYPWSEGS----------------------------TLSPPNYAEAMHSHSDSEKQSESGNAQEKS--------------YKPLYPVFDLSTSTVEKSKEAALDKEE-------------KK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9I7L0-1", "uniprot_id": "Q9I7L0_DROME", "id": "Q9I7L0-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "-----------------------------------------------------------------MTVTCEIDFDNNPHGTYFGG-----------EVLTGR------------VTLKLDKMKLVKAITLNITGYAETRWIERVT-TNRRRRRR---------------------------------------------------------------------------TFCGREDYIASKTFLVGS------NLSSQ--------------------------------------------------------------------------------------------VSIEAGIHTYNFVCLIPT--ECPSSFEGSHGRVRYMATVTLV------RPWKFDQSYTRCFTVLKVMDLNFDS----------------------------------PLLRVPAHSETSKTYCCWPCRSDPLALQLTVPQTG--FVPGQNVPLSVLVTNDSH------------------IPVEQLLISFVMLVTYHSK------------------------------------------------PPSMPNTTSERLVVNTFKGDAVQRNCKKLFSYEIRVPATPPTCFNL---------CGIIQIAYQVEVEARVKGCHN----------------------------NEVVTIPLTIGSVPLA-QHVPIQ------------PRGFVPQLNVN--------ELAVEEVATAPNSSSPWSVDA----------------------------SIPPPNYQEAVHMRSTAATRSDDLDDPEPVPPN---TLSLDGGAYKPLYPVFDIPSPSAPPPTDYTQNYMAERAFVNPAMDVDKDKGTWL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9I7L1-1", "uniprot_id": "Q9I7L1_DROME", "id": "Q9I7L1-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "-----------------------------------------------------------------MVVTCEISFDNNKHGTFYAG-----------QLVKGC------------ATLKCDRSKEVQAVLLKVVGYSITKWSEKSLGSTKL--------------------------------------------------------------------------------YVGREDYLSSNTYLVGSEQNNTHNNTHR--------------------------------------------------------------------------------------------LTIEAGVHSYNFTCQLPY--QCPSSFEGRHGCIRYIVKVLLI------RPWKFDQAYTKGFTVLKMLDLNFDT----------------------------------PQLKSAAHSEGYRTFCCGPCKTDPLKLELHLPQAG--YVPGQKIPVTIVVVNNTA------------------VAVSEIRLSLVMLVRYYSV------------------------------------------------SPEH--SRVERLIISRAKGESVLKQCTRSQTIDLPVPSTPPTCVEL---------SNLIQIAYQLEVEALVKSLRE----------------------------QQLMVMPVTVGTIPLAVSGIVVQQ----------PPRRSAHYEGPDS-RRNPPDELPMVTALESLPSDLASSAAD----------------------------SALP-NYEESRHTQRGNINEEELHAFGSNE--------------FAPLYPVYSIPSPTPVLTANARNAGFVN---------QSFVK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VI53-1", "uniprot_id": "Q9VI53_DROME", "id": "Q9VI53-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "----------------------------------------------------------------MGLKGCELQLDN-PWNTYYAG-----------QTVNGQ------------VKFTFDSPKKVRGIIIRFLGEANTEWSEEKSVTTSEGKTENE-----------------------------------------------------------------------VTQLKGHEEYFKIQYYLLGG------KNSSE--------------------------------------------------------------------------------------------TELPPGTHTYPFTCALPP--NLPSSFEGEFGHVRYTIKVTLD------RPWKFDQDMKMAFTVIAPVDLNLN-----------------------------------PRVKEPFKLELEKSFCCFCCRSGPLAVITNIPQTG--FVSGQVLPITCEVDNTSN------------------VNLTAVKFELRKLVTFHTN------------------------------------------------QPRS-EKRESKVIIANLSVGPVNGGESRTFTQQMEIPALPPTNLLN---------CGIIALDYDLHVECEVSGPHR----------------------------NLTGKVPITLGTIPLAGVRPPTQF----------TDAPSAVQSEDPSLAPTQPVSPASPPGGDGVGGALGWNVADSTGGGS-------------------LYPNIPPPQFVETQYRAPTIAGRDDSEHTQMIG-----------DGAFAPRYPTFQFNNATAPPASQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8BG60-1", "uniprot_id": "TXNIP_MOUSE", "id": "Q8BG60-1", "name": "Thioredoxin-interacting protein", "aln": "------------------------------------------------------------MVMFKKIKSFEVVFNDPEK-VYGSG-----------EKVAGR------------VIVEVCEVTRVKAVRILACGVAKVLWMQGSQ------------------------------------------------------------------------------------QCKQTLDYLRYEDTLLLEEQPTAGENEMV--------------------------------------------------------------------------------------------IMRPGNKYEYKFGFELPQ-GPLGTSFKGKYGCVDYWVKAFLD------RPSQPTQEAKKNFEVMDLVDVNTP------------------------------------DLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKG--FCEGDDISIHADFEN----------------------TCSRIVVPKAAIVARHTY------------------------------------------------LANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILG----------CNILKVEYSLLIYVSVPGSK-----------------------------KVILDLPLVIGSR--SGLSSRTS------------SMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESP----------------------------TTPLLDDVDDSQDSPIFMYAPEFQFMPP------------------PTYTEVDPCVLNNNNNNNNVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5M7W1-1", "uniprot_id": "TXNIP_RAT", "id": "Q5M7W1-1", "name": "Thioredoxin-interacting protein", "aln": "------------------------------------------------------------MVMFKKIKSFEVVFNDPEK-VYGSG-----------EKVAGR------------VTVEVCEVTRVKAVRILACGVAKVLWMQGSQ------------------------------------------------------------------------------------QCKQTLDYLRYEDTLLLEDQPT-GENEMV--------------------------------------------------------------------------------------------IMRPGNKYEYKFGFELPQ-GPLGTSFKGKYGCVDYWVKAFLD------RPSQPTQEAKKNFEVMDLVDVNTP------------------------------------DLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKG--FCEGDDISIHADFEN----------------------TCSRIVVPKAAIVARHTY------------------------------------------------LANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILG----------CNILRVEYSLLIYVSVPGSK-----------------------------KVILDLPLVIGSR--SGLSSRTS------------SMASRTSSEMSWIDLNIPDTPEAPPCYMDVIPEDHRLESP----------------------------TTPLLDDVDDSQDSPIFMYAPEFQFMPP------------------PTYTEVDPCVLNNNNNN--VQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H3M7-1", "uniprot_id": "TXNIP_HUMAN", "id": "Q9H3M7-1", "name": "Thioredoxin-interacting protein", "aln": "------------------------------------------------------------MVMFKKIKSFEVVFNDPEK-VYGSG-----------EKVAGR------------VIVEVCEVTRVKAVRILACGVAKVLWMQGSQ------------------------------------------------------------------------------------QCKQTSEYLRYEDTLLLEDQPT-GENEMV--------------------------------------------------------------------------------------------IMRPGNKYEYKFGFELPQ-GPLGTSFKGKYGCVDYWVKAFLD------RPSQPTQETKKNFEVVDLVDVNTP------------------------------------DLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKG--FCEGDEISIHADFEN----------------------TCSRIVVPKAAIVARHTY------------------------------------------------LANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILG----------CNILRVEYSLLIYVSVPGSK-----------------------------KVILDLPLVIGSR--SGLSSRTS------------SMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESP----------------------------TTPLLDDMDGSQDSPIFMYAPEFKFMPP------------------PTYTEVDPCILNNNVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58HG91-1", "uniprot_id": "A0AC58HG91_DANRE", "id": "A0AC58HG91-1", "name": "Thioredoxin-interacting protein", "aln": "-----------------------------------------------------------MGVLTKKPKAFEVQMSDPNKIAYSGG-----------DKVAGR------------VIVEVAELLKVSAVKLFGVGCAKVNYKKGKL------------------------------------------------------------------------------------HCSEEIEYLKYEEILHLDHHSTTDDEGSI--------------------------------------------------------------------------------------------TLRPGNRYEFMFGFELPQSGCLVSSYEGKFGSVQYYVRAVME------KSSQTFAECKRYFEVVEPIDVNTQ------------------------------------ELMAPVKGSKQKKVTCMFIPDGSVSIVASIGRKG--YCEGEDICIDAQFEN----------------------TSSRIVIPKAAIIAKHIY------------------------------------------------LANGRTKVFEEKLTSVRGNHIISGMGDIWQGRVLRVPKLKPTILG----------CDIIHVDYSLRIYLHIPGSE-----------------------------KLILELPLVIGTIPYNGMNSRTS------------SMSSQESASSTCVSL-----PSSPPSYSNIS---NRMDSS----------------------------FIPLLDDYDE-DDSPIFMQI-HHPLPPP------------------PLYTEQHI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VI00-1", "uniprot_id": "Q9VI00_DROME", "id": "Q9VI00-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "-----------------------------------------------------------------MPSSCSFELDRREP-IYYSG-----------ETVNGR------------AILTTTSEKSVNEVYILFEGEAKVRWDERRTRTRGGKTEHYT------------------------------------------------------------------------EYFRGKQQYLYTRTSVFGS-------------------------------------------------------------------------------------------------------GNLPPGTHTYNFCIPLPL--ECPSSVVAQYGKIFYEVSVVID------RQWRFNNVFKQPLTVIQTYNLNMS-----------------------------------PQLLMPLVREDIKHFCCWPCSSGPVLSTLTIPFGG--YAPGQKIRFTLEIDNQSSG-----------------YDLNGIELKLKQIYKFQAQ------------------------------------------------TPHHKTREKEHSLNKSCQQERVLRLSKKKIEGTLAIPAVPPSSRTEG----------IISVSYQVILTISTGDCHV----------------------------DSDFEVPIVIGTIPLIQSAENPAS-----------AAQWIPETPDTPAGAAADLPPSYDKCKPPTFEEATNFGER-----------------------------FIDIDQDEHNRTDDFIPRYPMYTNFAMPSAPP-----------QPPEEFATNQPVPVLSLPHDPTAPLVGQNNTDRPTQSYGWNTNS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4KGD9-1", "uniprot_id": "A0A0B4KGD9_DROME", "id": "A0A0B4KGD9-1", "name": "Arrestin C-terminal-like domain-containing protein", "aln": "-----------------------------------------------------------------MPIECLISFDNNPQGVYYAG-----------QELSGV------------VDLSVDATKRIKGIHVTVSGYAKIRWIKKGYPRDSER-----------------------------------------------------------------------------AMCRAYRSYLSSRSYVLGS----CANNSS---------------------------------------------------------------------------------------------IDWPAGEYSYTFHVILPD--NLPTSFDGKYGQIHYEIITTIE------RAARHPKVFKLPFTVIQPLDLNAD-----------------------------------AIYRVPLEILDRKRFWSFCCPTGPLTVKFSTPYCG--YAPGQKIHFVLYINNESS------------------IDIIECEVKLKQEVSYESH-------------------------------------------------DPQHEYRYDKHLIARKQFGNVLRWSRKVYRGYLDLPSIPPTSVKP---------TCPISVNYSIKIIVNPTEFHW----------------------------KLKLKIPLTIGSIPIMDGPEALLR---------FNRQQQQHQVVSQNLQMSTQQRQRDRDRDRDMNVDRERDRDRDRDRISASVQ----------------QRRISSINNNNNNHGRLVGGLLPTNSNMNMITNVS------PTPTSSTPSSTPTTAALRPTAMPAILVTSDSDNPPDYIPMMPPSYEDAMALSEKFSDDTEFLTNVSMSSILSAQ-----ADVTTSEP----------------------------------FKPRYPVYYDYETPTIPPETLYDESSSRLRLTLSCQDSAAPETDEDLAPNTRGGEPPSCEKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53179-1", "uniprot_id": "PALF_YEAST", "id": "P53179-1", "name": "pH-response regulator protein palF/RIM8", "aln": "---------------------------------MSLLRLWNKESRAPSKIKSHGIVGSYGNSMLAHNNVKQFRIDIDEPHRVWKP----------NESITGE------------AVIDIKRDITNVAIKLSLVCEVRVKTGNSPTSKNKRIEKTLEKS-----------------------------------------------------------------------TFLYGQDYVKTAFSAKEKKPHVDKTTILN---------------------------------------------------------------------------------------------GLSKGEHRFPFRIRIPRGRGMLSSIKFERGSITYFLSCTLESLNNINGLKKPEARCEREFAVIVPLDVSRLPKPKTKTVVLQSASMVQNKKNKSTEDESSSYTQLTQKSTTSNSSSSSVNSKTSPLPNKTVTISVDIPQAG--FMIGEIIPIDVKIDHYKPF-----------------YAPAGLTTTLVRICRVGGAG------------------------------------------------KDDPMETFRKDICQSISPIYINPETLQFQSRVYLKVPLDAFSTLTTVG-------KFFSFQYYIEVMVNLSKKNVVYT-------------------------ESNRIIGTPIGEQNGLGVENNINR-----------IQRKMLRMVNPETLENDSEGYESSIFFKDMVNVEKLKRLRNVTGMS--------------------IETVIGTTRSEQQQSDASIPSQSSITAPQNSPSNLR------DWLAPLNAYDSDDVPVPKYSPNDKVSVPSEDKQELEQKRLQQLESDPPPCDDY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q12502-1", "uniprot_id": "LDB19_YEAST", "id": "Q12502-1", "name": "Protein LDB19", "aln": "---------------------------------------MAFSRLTSTHQSNHNGYSNSNKKGQSLPLTLSIDVESPPCVLYGSAMESS------GAVLSGL------------FTVTVVDPYSSAEDKSLKNTESNVSTTSKSLKRK-----------------------------------------------------------------------------------STFGSALSSRLSSLSASTSNISPSTSS--------------------------------------------------------------------------------------------TSISHSPTPANLRIMAGYTKITITSVTLSLVQKIHFHKPFVPN----ISSMQTCMNCKTKITNMKSWEIQSN-------------------------------------TQDLSVGSHSYPFSYLIPGSVPCSSSLGATAET--QVKYELIAVVTYIDPHRNS-----------------FSSGHSTPRKEGSSSKKRLLQ-----------------------LAMP-------------------IAVTRSIPRGPDKNSLRVFPPTELTAAAVLPNVVYPKSTFPLEMKLDGVSSGDRRWRMRKLSWRIEETTRVKAHACPVH------------------------KHELRQLEEQVKIKESEKSKKPRSHIKR------YGELGPQIRVAVNSLENMPSQRLPGEPGREQAPNSSGPASTGNVG-----------------------LDDENPVNEDEEDQPGSEFIHPSDDALRQELLMQQ---------QRARQQQLQQELKNNSSLFTEEVRIISKGEMKSGWKTDFDNNGKIELVTEIDCMGLNSGVSNPVMHASTLQ-----TPSTGNKKPSINVACDIQDPNLGLYVSHILAVEIVVAEETLQYANGQPIRKPNSKNKKETNNNTMNVHNPDQRLAELSPIFANRNTPKVRRMGPEDITPVNSNKSNHSTNKEKASNGASNSNIVSVPTGAARVLRMQFRLTVTERSGLGISWDEEVPPIYQDVELLSPPCYELSINNGIKNKLYSTMSTPVRSEDDFVGGSDEDIGNYESQGLEPGPNVQEVTITQNKLTIPPTAHHYQPASSSQRSLTTVQSPPLESVVSVQGSVPFRGHVLTPHSTRDIRIQNFSDFLDSNRITQ-------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P38167-1", "uniprot_id": "ECM21_YEAST", "id": "P38167-1", "name": "Protein ECM21", "aln": "-----MPFITSRPVAKNSSHSLSETDLNQSKGQPFQPSPTKKLGSMQQRRRSSTIRHALSSLLGGANVHSPAVLNNTTKGGNNNGNIRS---SNTDAQLLGK------------KQNKQPPPNARRHSTTAIQGSISDSATTTPRSSTSDTNRRTSGRLSVDQEPRISGGRYSQIEEDSTVLDFDDDHNSSAVVSSDLSSTSLTRLANSKKFNEQFLIEYLTARGLLGPKTVLSNEYLKISISTSGESVFLPTISSNDDEYLSRLNGLNDGTDDAEADFFMDG--------------IDQQEGNTPSLATTAAATESGGSINENRDTLLRENNSGDHPGS----GSELNTRSVEIDSSMVSYSIAVIVSVKKPTRFTDMQLELCSRVKVFWN------TGVPPTKTFNEEFYNAASMKWNLNDE--------------------------------NFDLFVPLSISPDDQMIENNSNDRQMRLFKNIPTEE--RLYLDKTKTKASLLNAIDVNKTHLYQPGDYVFLVPVVFSNHIPETIYLPSARVSYRL-----------------------RLATKAINRKGFYRQDSNSPQPIVSPDSSSSLSSTTSSLKLTETESAQAHRRISNTLFSKVKNHLHMSSHQLKNEESGEEDIFAEYPIKVIRTPPPVAVSTANKPIYINRVWTDSLSYEISFAQKYVSLNSEVPIKIKLAPICKNVCVKRIHVSITERVTFVSKGYEYEYDQTDPVAKDPYNPYYLDFASKRRKERSVSLFEIRTKEKGTRALR---------------EEIVENSFNDNLLSYSPFDDDSDSKGNPKERLGIT-EPIIIETKLKFPKYEDLDKRTAKIIPPYGIDAYTSIPNPEHAVANGPSHRRPSVIGFLSGHKGSKSHEENEKPVYDPK-----FHQTIIKSNSGLPVKTHTRLNTPKRGLYLDSLHFSNVYCRHKLEIMLRISKPDPECPSKLRHYEVLIDTPIFLVSEQCNSGNMELPTYDMATMEGKGNQVPLSMNSDFFGNTCPPPPTFEEAISVPASPIVSPMGSPNIMASYDPDLLSIQQLNLSRTTSVSGPSGYSDDAGVPNVNRNSISNANAMNGSISNSAFVSGNSGQGVARARATSVNDRSRFNNLDKLLSTPSPVNRSHNSSPTNGLSQANGTVRIPNATTENSKDKQNEFFKKGYTLANVKDDEEQEGIVSSSSADSLLSHGNEPPRYDEIVPLMSDEE-----------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q12734-1", "uniprot_id": "CSR2_YEAST", "id": "Q12734-1", "name": "Transcription factor CSR2", "aln": "MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTSLSPQKSSGFSGRRRSSSVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGNSFPSDVGTKAYNITGSYQPDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNNDIVRSFITHHASNSTMFINRVLSDYLADRGFIKQTPLYNKKSVLEISIATSAES----------VFLPTTKSDETEYLSLIHGSLNQARTQPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHTQRTSPSNTARTGNAMDTSNSDRASPASNNNTTDADSFVASGNNNPMNNNNSPARNRHPNSHSRSLPNAWNSQMPSFSFALIFSLNKSTTLSDIKVELTSNVRVVWFN------GLPPTKNVNEECYNIGSLDWTLNADN--------------------------------FNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIPITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPS---------------IREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKT--------KLKFPKYCEVDATKAASLPPYGIDLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQDKNHNEVNDTNGNSNTSLQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRVSKTDSGSSKIIRHYEVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSVSASPRSSVSYYPDDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQARPLRTEDYALQMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSPRTFTNTDYNYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS----------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . : : : ", "identical_positions": 1, "similar_positions": 5, "identity": "0.08%" }, { "cls_id": "homologset.agr.HGNC:16953", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62009-1", "uniprot_id": "POSTN_MOUSE", "id": "Q62009-1", "name": "Periostin", "aln": "------MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQ-----------------GPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLG----------IVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVNVELLN------------------ALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGN-----------QIATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSS---FRAAAITSDLLESLGRDG--HFTLFAPTNEAFEKLP-----RGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGD---SISINGIKMVN------KKDIVTKNGVIHLIDEVLIPDSAKQVIELAGK--QQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLK------LILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIEN-----------SCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKG-----MTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEP------KIKVIQGSLQPIIKTEG-PAMTKIQ--IEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVP----------------------------------------------VEITEKQTREERIITGPEIKYTRISTGGGE--------------------------------------------------------------------------------------------------------------------------------TGETLQKFLQKEVSKVTKFIEGGDGHLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AHK0-1", "uniprot_id": "A0A8I6AHK0_RAT", "id": "A0A8I6AHK0-1", "name": "Periostin", "aln": "------MVPLLPLSALLLLFLCDVDPANANSYYDKVLAHSRIRGRDQ-----------------GPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLG----------IVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVNVELLN------------------ALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGN-----------QIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSS---FRAAAITSDLLESLGRDG--HFTLFAPTNEAFEKLP-----RGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGD---SISINGIKMVN------KKDIVTKNGVIHLIDEVLIPDSAKQVIELAGK--QQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLK------LILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIEN-----------SCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKG-----MTNEEREILIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKLVEP------KIKVIQGSLQPIIKTEG-PAMTKIH--IEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVP----------------------------------------------VEITEKETREERIITGPEIKYTRISTGGGE--------------------------------------------------------------------------------------------------------------------------------TEETLQKFLQKEVSKVTKFIEGGDGHLFEDEAIKRLLQGDTPAKKIQANKRVQGSRRRSREGRSQ-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15063-1", "uniprot_id": "POSTN_HUMAN", "id": "Q15063-1", "name": "Periostin", "aln": "------MIPFLPMFSLLLLLI--VNPINANNHYDKILAHSRIRGRDQ-----------------GPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLG----------IVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLN------------------ALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGN-----------QIATNGVVHVIDRVLTQIGTSIQDFIEAEDDLSS---FRAAAITSDILEALGRDG--HFTLFAPTNEAFEKLP-----RGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGD---SITVNGIKMVN------KKDIVTNNGVIHLIDQVLIPDSAKQVIELAGK--QQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLK------LILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIEN-----------SCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKG-----MTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPVTVYTTKIITKVVEP------KIKVIEGSLQPIIKTEG-PTLTKVK--IEGEPEFRLIKEGETITEVIHGEPIIKKYTKIIDGVP----------------------------------------------VEITEKETREERIITGPEIKYTRISTGGGE--------------------------------------------------------------------------------------------------------------------------------TEETLKKLLQEEVTKVTKFIEGGDGHLFEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IS83-1", "uniprot_id": "A0A0R4IS83_DANRE", "id": "A0A0R4IS83-1", "name": "Periostin", "aln": "-------MKLLFAATFALFVLSAFDQADS-SAYDKIVAHSRIRAKKQ-----------------GPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLG----------LVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYN------------------ALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGN-----------QVATNGVVHVIDRVITAVGSTIQDMIEVEDDLST---LSTVATDSGLIDKLGEPG--HFTLFAPTNAAFDKLG-----REVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGD---SLTVNGIKMVL------KKDIVATNGVIHLIDEVLMPDSAKQVMELVGQ--SQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLK------IILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIEN-----------ACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAG-----LSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVIT---------------VPGDVTKVTRVIQGEPTITKVTRVIEGAP------SVTKVTRVIEGQPSITKVTRVIEG---------------------------------------------------QPSLTKVTRVIEG-DPSMTRV---------------------------------------------------------------------------------------------------------------------------------------------IEGPEYSVTSSTDTELYDFGEDSEGITTFIQEG--TRRVPP-RRVQGGVRRRT----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1RKG7-1", "uniprot_id": "A0A8M1RKG7_DANRE", "id": "A0A8M1RKG7-1", "name": "", "aln": "-------MILLFTATFTILVLSSLDQVDS-SAYDKIVSHSRIRAKNE-----------------GPNVCALQQVMGTKKKYFSTCRNWYKKSICGKKAIVLYECCPGYMKLEGKRGCPAVAPIDSVYGTLD----------LVKAKTTQQYADQSKLREEIAGEGSYTIFAPSDDAWEELDPASKAAVISLGNTELYN------------------ALHYHMVSKRFLTKDLKNDMTLESMFNKQGLHINHYSNGVVTVNCARIIHGN-----------QVATNGVVHVIDRVISVVSQTIKDVIETNDDLSS---LSGVVVSADLQDQLGEPG--HYTLFAPTNEAFDKIN-----ADALERLMSDQTVIQALLKYHLLNSVQCSEAIMAGSIYGTLEGSNIEIGCDGE---SLTVNGIKMVL------KKDIVTSNGVIHLIDQVLMPDSAKQVMELVGK--SQSVFSDMVSELGLSAALQPETEYTVLAPLNGAFSDEVMSMDQRLLK------IILENHIVKLKVSLRDLYNGQLLETLGGKMLRVFIYRTAVCIEN-----------ACMVRGSREGSNGALHLMSSLIQMPETTIYELLLKDGRFKIFLSLMESAGLTDLLKQDGSYTLFAPIDAAFGS-----LTKDDLALLKSDINVLRTILLYHFSNGIFINGGLEGGVTNLLKTIQGNNLQVLSVNSSIHVNSVDVPDFDLMASNGVVHVVKTLLYPQDLPVGREDILILLKRLIKYMQLKFVSGYTYRDIPLTFIKRTITTHVIERGPGTTVERTVIGEPIKVTRVIEGQPGVTKVTRVIEGDP------SVTKVTRVVEGQPGITKVTRVIEGDPSFTKVTRVVGDQSLTKVTRVVEGDPRFTKVTRVVEDDPSLTKVTRVVEGEPSFTKVTRVVEG-DPSFTKVTRVVGDPSLSKVTRVVEGKPSVTKVTRLIESHSASSDGEIDAGGEIKGIVGDDISNVQRFQNGEVHILQEEDIKQITDAIAQGGGPGITTITRVLKPEPRVVESEPGITTFTRVIKKKPQIVDGAPLETTFTRVIKPEPQIIEGPDFSKIVSLKDNPELFESETERITRIIKDGRSRKRAAI-RQLQGSRRRARLVRHPTKPTQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q86B94-1", "uniprot_id": "Q86B94_DROME", "id": "Q86B94-1", "name": "", "aln": "MLRLWACLLLLGSIQIQAVPFYGDSSSEEVAEFDDSSDSTHESSDNSSFMPHLTHPLPAHRNLFAPLPFAPLAPLEPQDPLHAQASQRMASVWNGPAPLAPQLHSSHLLPLFSSGYDTEFVPLEHQQQPQGRQETAATVPAQTPSGVEQKPFNVDTITTDVNSPNPAIFFQQSFPFFGNEFFNSFGGFGFGAAQEPWWKGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTKIVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEKIDIKDVEATASDMGAKQFLESARTAGELADMLGAGSGKKVTLFVPNDAAFMEYRGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLP-AALGLEPYRFAANCVPIEKHDKLSEQALVHTLGGVLKP-LTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPHLRRALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNLLGEPLLLNRTHRAANQTGPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPMIKTCDLSEKSLPTVAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPNYSKFLELVRKANLTQLLSNDSRSLTLLVPKN--------DIFEELNESGEGSKPADPMALVK--------------THIVEDVVCCAGIIPTN----------------------------------------------------------WPFVRSIESISGQHLRITRDRR-----------------------------------------------------------------------------------------------------------------------------------------PKIENAGVTKCDVVATNGILHEINDIIVPRPQRQQQQRPQLIPPGAGYQPQGDFDVFF-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07895-1", "uniprot_id": "YL001_YEAST", "id": "Q07895-1", "name": "FAS1 domain-containing protein YLR001C", "aln": "----MNMAIQTIKYIFWLLPILGLTQALLQNPGDDFPFSTVIDILSEN------------------VEFSTFLRIIQKTGHVQYLNELQNFTLFAPINSAFIKGDQTTDQFEEHFHIEDFLIHDRVLQVRD------------LENGTYLEKRAAKAPLLLRKHERHCFVNEIAVVEPDLLPSFQNASLQGINNLLLIQP----------------QINELLVQLDEETQDLKIFSDFISSFSNYNAYTNSSTVLVPLDVNFRKFFNTIEIN---YLLDKYNKLGKSNTISQAKWAADRTSLLQELIIDDVYGGILPKELILENKNNRKLFMKSNSEGTSVSVNNSDYSPISN----RIFEIGVVHGFSDLDFLRTHIQFDAEKYLHGLNCSEFVKELYFRDLEKFIQNGRKITIFVPQASFNE------DRGYTKPSLLYHFVEGKIDLEQDFSSLRPIQY--APTQIYDSAFCSSAKRLGGHCQKFKITRSNKGYYINGRFKILNTKPYEIGNTSIYSIDDDLQLPGDLVLSLAPENHCSISLMLLKELNLLDLPSNHKG---------YTILLPCMNSWDNNDLTIDYLRSNKTALNLLMRNLIFEDLIYSNNYSISTTVKNLYGNSVSIGVQKIVGSQNLTKIS-VSTIKESIIIEESSDIFFNQGVIHPIDQLDFPVDLEISLKELIETTGTKEIFDFFNLFYDLSSIIWNNEEYSLLVPTASSIPLSGITANSTNLRKFLELHLIPANVTQNLLDCNGSISTKLGTKLNCRKDHLDNVFVS---------IQGDWTKEVRVLKTGCTTNLKSSCIFLIDKPISLSWLNSEKYHLRLPGIAVGFGVIIG-------------------------------------------------VTIAISLLFCIIITRGGKVKDKNQRGRNDR----------------------------------------------------------------------------------------------------------------------------------ATTPLIQHSPIIHNPSYSATAHLSPLSQPTFEGSYSVNAIQTPRDIRRVGSDQKGGRSVSTS------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : *. : .. : : : : . . : . : . . : . . :. :* . :.. * . : . . * . . . .:: * . . * . .: : . : :. : . : :. :: : : .:. . : * : : . : : : . .: . . : . : . :. :. : . : . .: : : *. : : : :: : : . : . : :: . : : : * .: : : :: . : * :: : : : : : * . .. : . . ", "identical_positions": 11, "similar_positions": 128, "identity": "0.97%" }, { "cls_id": "homologset.agr.HGNC:16954", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ALJ9-1", "uniprot_id": "A0A8I6ALJ9_RAT", "id": "A0A8I6ALJ9-1", "name": "small monomeric GTPase", "aln": "-------------------------------------------------------------------------------------------MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDSPRLYRPAVLLDGAVYDLSIRDGD-FAGPDSSPRSLEEWPDPKDWSLQDTDAFVLVYDICSPDSFDYVKALRQRIAENRPAGAPEAPILVVGNKRD---RQRLRFGPRRALATLVRRGWRCGYLECSAKYNWHVLRLFRELLRCALVR-------------TRPAHPALRLQGALHPARCSLM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K5A4-1", "uniprot_id": "RSLAA_MOUSE", "id": "Q8K5A4-1", "name": "Ras-like protein family member 10A", "aln": "-------------------------------------------------------------------------------------------MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDSPCLYRPAVLLDGAVYDLSIRDGD-VAGPGSSPRSLEEWPDPKDWSLQDTDAFVLVYDICSPDSFDYVKALRQRIAENRPAGAPEAPILVVGNKRD---RQRLRFGPRRALATLVRRGWRCGYLECSAKYNWHVLRLFRELLRCALVR-------------TRPAHPTLRLQGALHPARCSLM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92737-1", "uniprot_id": "RSLAA_HUMAN", "id": "Q92737-1", "name": "Ras-like protein family member 10A", "aln": "-------------------------------------------------------------------------------------------MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDGPRLYRPAVLLDGAVYDLSIRDGD-VAGPGSSPGGPEEWPDAKDWSLQDTDAFVLVYDICSPDSFDYVKALRQRIAETRPAGAPEAPILVVGNKRD---RQRLRFGPRRALAALVRRGWRCGYLECSAKYNWHVLRLFRELLRCALVR-------------ARPAHPALRLQGALHPARCSLM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58JGR7-1", "uniprot_id": "A0AC58JGR7_DANRE", "id": "A0AC58JGR7-1", "name": "", "aln": "----------------------------------------------------MLLTVCFTKKDNEMYQKTTHLGFRVCRSAVAGFGPDRRGMVETLSIAVIGAPGVGKTSIIRQFIYNDFSETYTPTQTRYVYRPSVILNGVMYDLKILDVPPISSFPSSPS--QEWLDSRCRGVRSANAYILVYDICCVESFEYVKMIRQQIVDNRVGSSSEVPILVVGSKRD---LQRQRFTQRRAVSVLVKKTWKCGYVECSAKYNWHVLLLFKELLGIAVSRG------------LRPNHTSIRLQGALQRNRCTVM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VNB7-1", "uniprot_id": "Q9VNB7_DROME", "id": "Q9VNB7-1", "name": "Ras-like protein family member 10B", "aln": "MWSSTISPTNSKKLLIGSTRSVDYVGDSARTAAGNIKTGAAAAAGAKGSKSKATATAPTTKISIEMELHIQNKCISAXRITLEG-GAEPPWLQGPLKAAFLGATGVGKTSILQQFFYHDFPRTHQTTTHRKIYKNCLVCDTCIRELMVLDVP--PQKRFPADNFAEWNNGHPLGLRTVHAYVLVYDMGNLETFQYCRSMRDQILDS--FSHRDFSIIVVGNKFDNVTEAQANSQELKDISTLVRKHWRCGYVECSAQYNYKIGDVFRELMGCTSAVGGGGAGGGGGVAGVGGLVGTEYSQSTRNKGRCTIL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .* *.:**.*****:*::**:: *:.. : .* :*: .:: : : :* : * . .. ** : : .:: ..*::****: ::*:* : :*::* :. . : .*:***.* * : . : ::.**:: *:***:****:**::: :*:**: : : *.: : **:::", "identical_positions": 52, "similar_positions": 76, "identity": "16.72%" }, { "cls_id": "homologset.agr.HGNC:16955", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2KAY0-1", "uniprot_id": "A0A0G2KAY0_RAT", "id": "A0A0G2KAY0-1", "name": "", "aln": "MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTKAARALAAAR-------------------PTRGVAFQAHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELR---------ATPQASSVPAAEEDVTEIAAA-----------------------PGAPARTPRMTPN------DIRNLDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRCTSSTHRLPQQRTGTFSPQ-RGSPTPSPRPGSPVPGS-----------ERR-------------SSRP-----EVTPISLRSTKEGPETPLR--PRDQLPP-----------LPRSRRYSGDSDSSASSAQSGPMG-----------------------------------------ARSDDSATGSRRERPNHRLTSGLTASP--------------------------RRPPTPRSQSRDR-LDRGRPRMAPGGRGAQLSASSPARRTR----------SQNREEQAVLVVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRARSP--------------------AAPRPSRGP-----SPGPELAATPASIFRTP-------------------------LQLDPQQEQQLFRRLEEEFLAN----------------ARALEAAASHTLMG------SAPDHPAPDSAYCSSSSSSSSLSVLG--GKCGQPRESGRTAN------------------GLP----------APRS-----QALSSSSDEG---SPCLA--------VGRTLDAARSSLAGPEPSLTWA--------------------------------------------------------------------------------------------------------RGRMDTQPDRKPSRIPTPR------------------GPRRP-----------------------SGPTELGAWHALHSVTPRTEPDSSM----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8JZP9-1", "uniprot_id": "GA2L1_MOUSE", "id": "Q8JZP9-1", "name": "GAS2-like protein 1", "aln": "MANPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTEAARALAAAR-------------------PTRGVAFQAHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELR---------ATPQVSSVPAAEEDVTEIATV-----------------------PGVPTRTPRMTPN------DLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSSTHRLPQQRTGTFSPQ-RGSPTPSPRPGSPVPGS-----------ERR-------------SSRP-----EVTPISLRGTKEGPETPLR--PRDQLPP-----------LPRSRRYSGDSDSSASSAQSGPMG-----------------------------------------ARSDDSATGSRRERPSHRPTSCLPASP--------------------------RRPTAPRSQSRDR-LDRGRPRVAPGGRGAQLSTSSPARRTR----------SQSREEQAVLMVRRDRDGQHSWVARGRGGGGSGGSGRSTPQTPRALSP--------------------AAPRPSRGP-----SPGPELAATPASIFRTP-------------------------LQLDPQQEQQLFRRLEEEFLAN----------------ARALEAAASHTPMG------SAPDPPAPDSAYCSSSSSSSSLSVLG--GKCGQPGESGRTAN------------------GLP----------GPRS-----QALSSSSDEG---SPYLA--------VGGALDATRSSLAGPEPSLTWA--------------------------------------------------------------------------------------------------------RGRMDTQPDRKPSRIPTPR------------------GPRRP-----------------------SGPIELGAWHAQHSVTPRTEPDSSM----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99501-1", "uniprot_id": "GA2L1_HUMAN", "id": "Q99501-1", "name": "GAS2-like protein 1", "aln": "MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAAR-------------------PARGVAFQAHSVVPGSFMARDNVATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELR---------AAPPAPNAPAAGEDTTETAPA-----------------------PGTPARGPRMTPS------DLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRPPQPRVCTFSPQ-RVSPTTSPRPASPVPGS-----------ERR-------------GSRP-----EMTPVSLRSTKEGPETPPR--PRDQLPP-----------HPRSRRYSGDSDSSASSAQSGPLG-----------------------------------------TRSDDTGTGPRRERPSRRLTTGTPASP--------------------------RRPPALRSQSRDR-LDRGRPRGAPGGRGAQLSVPSPARRAR----------SQSREEQAVLLVRRDRDGQHSWVPRGR---GSGGSGRSTPQTPRARSP--------------------AAPRLSRVS-----SPSPELGTTPASIFRTP-------------------------LQLDPQQEQQLFRRLEEEFLAN----------------ARALEAVASVTPTGPVPDPARAPDPPAPDSAYCSSSSSSSSLSVLG--GKCGQPGDSGRTAN------------------GLP----------GPRS-----QALSSSSDEG---SPCPG--------MGGPLDAPGSPLACTEPSRTWA--------------------------------------------------------------------------------------------------------RGRMDTQPDRKPSRIPTPR------------------GPRRP-----------------------SGPAELGTWHALHSVTPRAEPDSWM----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q515-1", "uniprot_id": "F1Q515_DANRE", "id": "F1Q515-1", "name": "", "aln": "MAD-QSNIQSAASKSIRPFKSSEEYLYAMKEDLAEWLNTLYDLDIT--ADTFMEGLETGCALCRHANNVNRAAHEFKANCPD----------AALSLRIPSKDVVFQSRNVIPGSFLARDNVSNFIGWCRQELWIKDVLMFETNDLVERCNEKNFVLCLLEVARRGAKFGMLAPMLIQLEEEIEEEIRDQENLTEVMGETGESESPPKRTYTRKQSIG-----------------------EPDPELLARWREQQKRVLLDMRNLDELVREILGQCSCPSQFPMTKVSEGKYKVGDSSALIFIRVLRTHVMVRVGGGWDTLEHYLDKHDPCRCAAYAHRYQQAKASGQAPHSKSSSTHSSRSTSPGPHWRNEGIAPYKMPDRRSLDPAMGTTAQSSPSRPGRSHHAAVPVEMDTNTGRPTTLLPRPPRDRSEPRHFNPLRNKESLLPARRLSGDSDSSTASSKGGSTGGGRFSLGTRHAHADEVVLLVNRKEGKHVIERPGGAAQIPALRTPQTRARSASRERPAQQASTILKPSPPQGLAEVHRTPH--TERGRSLGPDGPRKLQTPRSLSQGK-TPRGRLGDVSPGSSPRRKDPHPLSIDRREELRPKHVPTASPKLSGSMPRRQANSSGSNSPAKGCTSGSPAKKGMVMPRPPAPRSPSSGSRKLLPPVTQPGRRSPHSSPRSSHHP-----PRSPRSAHNSRSIGRDQRVWANPHNQQQESQEDSSIFSLHLLPSLDPQREQDLYRSFEAEFLANTQQAKAGHGKASAGREMRSLQLPGSQQALGVLPN--SSGDTNVTDSAYSSSNSSTSSLNVGGKVGVLPDLRESKRTNSRTCALEDPPALLHSQIRGGLTNGGMMEGERWGGRSGLRKLPAISSSIEEGETSNPGLSRSVCHPKDINGSLPLTEVPMESQEELVEWPGLEADVPQCEHHPDLPYDNADQPLPESFPSPPPPVDDCSYQDSSSESSSMCLSLSEPPSEGSCTPPRPLANGDADGTVVLRAKKSQKKAERVPSIYKLKLRPRIRPRTDNRPDNSPSRIPTPVRYANHCHQSPANSSPLQTPPQSPRINNHQPSHKALHQAIADLIQPQQRSTAMGSRECAYSSESSLDNEAWMS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W3Y4-1", "uniprot_id": "GA2PE_DROME", "id": "Q9W3Y4-1", "name": "GAS2-like protein pickled eggs", "aln": "-------MAMLEARPYRPFKSSEEYLEAMREDLAEWLSTLY-PELSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSMTRSMTSGLAGPILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGMLAPMLVQMERQIDREIAADIKANGAGCSENGTQTDALETGNSSAATMTTITTTTVETDLYDDSDDSETEDDGDQNPVLMYGPQPQIITNDLKSLDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCRAQHRSSVAARLIPRQSPNHNPSNGIELHKAQVIFERSP-------PAARRVFNSPNCNGGPGTGSSCGTGVVGVAVPPTLQNGHSLSPNSGKYRSRSPTPQRKFLNQQANGGGIASATGSSQTVTTDTSSGQLLGSPSLARRSMSPSPRRLIDMRKKQSSLDSYSSGPKSLPGYSCSMEEANGGSGVGSAAGGVSSGSAGSGVAGEQGGANKFENISDNGSEISDEGYRSLGVIQSGAQKRESLHSQASIEDAESNARLDQTSSDSQISPSDEPAEKATTDILEEEDLNGQDREEDQEDYSVCDGPQSLPAILSGAHKLSDKFEQSGVFITDDEITVDIAKTEDQSVANTMGNPTPNLSKIPRSPLAQRRRRSIDNSTCGGAG--------GSLQDLSSRSGLPAPAFSRKQPVYRSVRTRNSTG--------ATTTPVAPPRSRQATQLPMVRDVTNTWSGRTTGAPKRRPPCTADTFVAPTNGTGPAGSFERNGKGRSSQILYDS---------------------------NGRRVRSGAPGCTSSLTTSPVKNHASSPLAQQLLEAASSAKNDAQILEKMKSLLSRYAAGNQTKAG----------------------------------------------------------------------------------------VGATATAANKINSNGKKTPVYEDFTTAWVHSNGNLERSESCSPPAKARSKRSSAASSCESNNSNAGAGSGAAAGSASVVSPRRERGMSKIPAPVRHHTELY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ::. ***:*** *: **:****:**.:** :. .* *: * ** :**:*** * .** * : . .. . .*:*:*****:.** *** .* : : *:***:**: * *** .:***********::*:*** *:*:*.:*:.*: .. . . : . *::.***:**::: :*:**.**** :******::**:. ***:*:**.*************.*********** : : : . : ... : * . . ..: . . : *.: . :*.*:: ::.:..* : .. . :: * * . :* :: : :.: ..: . . . : : . : .. * . .* * : . . . . .* ** . .::* ::* .. . :. *: : . . .::.: :. . * * .. : * . :** . . . . : : : :.. ...* . . . : : . . ", "identical_positions": 148, "similar_positions": 182, "identity": "13.18%" }, { "cls_id": "homologset.agr.HGNC:16956", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K634-1", "uniprot_id": "A0A0G2K634_RAT", "id": "A0A0G2K634-1", "name": "", "aln": "------------MVRPTRNKKPVNYSQFEDSGNDSDDDFISASIPVNK-SKTVPKVLKQDKPKPNLKNLQKEEVLPTE-PPKK-----------------RMALDDKVFQRGLEVALALSVKELPTLTN--QVKKPEERSTDTTGKRKTEKTDKPPRVSNCSVASDDVD-LNKITEEG----------------DVRDVEGERRTTSKARAQQRRKLSEGSSGSSADGTEPDSATGEDSESDPDFDESEESDED--FGVRRG--KETKKKPVQKKPKAEKKERKSKPKREEASVTSADPAPAAIKSGSPALPQPVGLPSEATRKPAKICSPSAESKRPKWVPPARDGSVELDLTVCLCVLLQPPPGAETLAAAHGQEPPPGPRVRACVWASPD-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C551-1", "uniprot_id": "R51A1_MOUSE", "id": "Q8C551-1", "name": "RAD51-associated protein 1", "aln": "------------MVRPTRNRKPINYSQFEDSGNDSDDDFISSSTPVNK-SKTVPKVLKQDKPKPNLKNLQKEEVLPTE-PPKK-----------------RVALDDKVFQRGLEVALALSVKELPTLTN--QVKKSKEKSTDKQGKEKTENTGKPPRVSNCSVASDDVEDLDKITEEG----------------DASSVEGERKSPSQAKAPRRRAPSEGSDGSSANDTESESATGEGSESDPDFDESKESDED--FGVRRS--KESKKKTVQKKPAGEKKERKSKPK-CEASVTSVDPAPAAIKSGSPSLPQAVGLPSEATRKPAIMCSPSAESKRPKWVPPAASGSRNSSSNALAGTPAKSPSQSLRLGLSR---LAPVKRLHPSATSSQVR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96B01-1", "uniprot_id": "R51A1_HUMAN", "id": "Q96B01-1", "name": "RAD51-associated protein 1", "aln": "------------MVRPVRHKKPVNYSQFDHS--DSDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEEIPVQEKTPKKRLPEGTFSIPASAVPCTKMALDDKLYQRDLEVALALSVKELPTVTT--NVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLD-LDKITVED----------------DVGGVQGKRKAASKAAAQQRKILLEGSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDED--FSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSK-CNALVTSVDSAPAAVKSESQSLPKKVSLSSDTTRKPLEIRSPSAESKKPKWVPPAASGGSRSSSSPLVVVSVKSPNQSLRLGLSR---LARVKPLHPNATST---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58J6R7-1", "uniprot_id": "A0AC58J6R7_DANRE", "id": "A0AC58J6R7-1", "name": "", "aln": "MLKLPMCSSSKLCSSSFRSKKTVNYSDFQDD---DDEDFACVKPPPKK----ARTDSDSEKSSKTTSTPANGDVDLASSESRK-----------------RVSLDAKRYERDLEEALTLSLREASKAQDGEPTTKSDGGSADDDGGSRPP-QCAPPVLIHCSADDIHPAGEDQPRPESPPVLSNCSIDGRSLGLNIISLDSSPPMPSKWTESSEKRRKSQKEKRNKDDDDYQPQNTPDSESDADFTEEEENDEDETFTVKKKKDKVVKQKTGKKATPAVKEKKEKKPT-KAVKAKSTAPSPSVCRSPAAPVSISKKAPSTPPISKPALCSSPAGGRLPKWNPPGMVGRSPGASQ---NGSLKSPGQGLRLGLSR---LARVKPLHPNVAAN---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * :*.:***:*:.. .*:** . . * :* . . ..:*.. . .. : :: . .:* :::** * ::*.** **:**::* .. . :.. * : * : .* : :**. . :: *. : .::.. .*: .: . .. . :. : : .**.*.** *.::.*** * ::: * *:* : . *::::.*.. . ..*. .:*:. :* : .:. .* .. . : *..* .: *** **. * :.* . *. :: . ::. . :. ", "identical_positions": 60, "similar_positions": 128, "identity": "15.23%" }, { "cls_id": "homologset.agr.HGNC:16959", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5EGY4-1", "uniprot_id": "YKT6_RAT", "id": "Q5EGY4-1", "name": "Synaptobrevin homolog YKT6", "aln": "-MKLYSLSVFYKGEPKAVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSAKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWP--VGSPATIHYTALDGHLSRYQNPREADPMSKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQW1-1", "uniprot_id": "YKT6_MOUSE", "id": "Q9CQW1-1", "name": "Synaptobrevin homolog YKT6", "aln": "-MKLYSLSVLYKGDPKAVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSGKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWP--VGSPATIQYTGLDDHLSKYQNPREADPMSKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15498-1", "uniprot_id": "YKT6_HUMAN", "id": "O15498-1", "name": "Synaptobrevin homolog YKT6", "aln": "-MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWP--VGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZUN8-1", "uniprot_id": "YKT6_DANRE", "id": "Q7ZUN8-1", "name": "Synaptobrevin homolog YKT6", "aln": "-MKLYSLSVLHKGSTKANLLKATYDLSSFSFFQRSSVQEFMTFTSALIVERSALGSRASVKEQEYLCHVYVRNDNLGGVVIADSEYPSRVCFTLLDKVLDEFSRQVNSIDWP--SGSPATIQYTALDSHLARYQNPREADAMTKVQAELDETKIILHNTMESLLERGEKLDDLVQKSEHLGNQSKAFYKTARKQNSCCEIM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W3M8-1", "uniprot_id": "Q9W3M8_DROME", "id": "Q9W3M8-1", "name": "", "aln": "MVKLFALSIFHKGASEARLLKTASDLQSFSFFQRGTVNEFMTFASKTIVERTQPALRQSVKQDAYMCHVYVRADNLAGVLIADHEYPHRVAHTLITKILDDFTAKVSADQWP--NGTEATISFDLLPAFLARYQNPVEADPLTKMQNDLDETKIILKNTIEAVLERGEKLDDMVSKSEKLSLQSKAFYKTAKKTNSCCSFT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P36015-1", "uniprot_id": "YKT6_YEAST", "id": "P36015-1", "name": "Synaptobrevin homolog YKT6", "aln": "-MRIYYIGVFRSGGEKALELSEVKDLSQFGFFERSSVGQFMTFFAETVASRTGAGQRQSIEEGNYIGHVYARSEGICGVLITDKEYPVRPAYTLLNKILDEYLVAHPKEEWADVTETNDALKMKQLDTYISKYQDPSQADAIMKVQQELDETKIVLHKTIENVLQRGEKLDNLVDKSESLTASSKMFYKQAKKSNSCCIIM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :::: :.:: .* :. *. . *:..*.**:*.:* :**** : :..*: . * *::: *: ***.* :.: **:*:* *** * ..**: *:**:: :*. : :: * .:::**:* :**.: *:* :******:*::*:* :*:******::*.*** * .** *** *:* **** : ", "identical_positions": 74, "similar_positions": 70, "identity": "36.82%" }, { "cls_id": "homologset.agr.HGNC:1696", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P21855-1", "uniprot_id": "CD72_MOUSE", "id": "P21855-1", "name": "B-cell differentiation antigen CD72", "aln": "MADAITYADLRFVKVPLKNSASNHLGQDCEAYEDGELTYENVQVSPVPGGPPGLASPALADKAGVGSEQPTATWSSVNSSALRQIPRCPTVCLQYFLLGLLVSCLMLGVAVICLGVRYLQVSRQFQEGTRIWEATNSSLQQQLREKISQLGQKEVELQKARKELISSQDTLQEKQRTHEDAEQQLQACQAERAKTKENLKTEEERRRDLDQRLTSTRETLRRFFSD-SSDTCCPCGWIPYQERCFYISHTLGSLEESQKYCTSLSSKLAAFDEPSKYYYEVSLPSGLEELLDRSKSYWIQMS--KKWRQDSDSQ-------SRHCVRIKTYYQKWERTISKCAELHPCICESEAFRFPDGINLN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P21854-1", "uniprot_id": "CD72_HUMAN", "id": "P21854-1", "name": "B-cell differentiation antigen CD72", "aln": "MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD-----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:***********.***:* *.:**** * :***:*******..* * *..***..*.***.* ******:* :*.*.*: :* * *.**:*:*****::**:***:.***********:*:*: .*: *.*****:**** **:****. :** :*:** .**::** :**:*: ** *******:* ****.*::**::** *:*:*:. .: *: **: *:*****.*** :*: ***** * . :**** * :******:*.* :. : ..* . .:*** :* *.*: .*:* * :* :::. :. * ..* . * *** ****** ", "identical_positions": 189, "similar_positions": 93, "identity": "51.92%" }, { "cls_id": "homologset.agr.HGNC:16960", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q1XID0-1", "uniprot_id": "LBX1_RAT", "id": "Q1XID0-1", "name": "Transcription factor LBX1", "aln": "-------------------------------------------------------------------------------------------------------------------------------MTSKEDGKAAPGEERR-RSPLDHLPPPANS----------------------------------------------------NKPLTPFSIEDILN--------------KPSVRRSYSLCGAAHLLAAADKHAPGGLPLAGRALLSQTSPLCALEELASKT-----------------------------------FKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSG-----QMDIVALAELEQNSEASGGGGGGGGGGCGRAKSRPGSPALPPGAPQAPGGGPLQLSPASPLTDQRASSQDCSEDEEDEEIDVDD-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P52955-1", "uniprot_id": "LBX1_MOUSE", "id": "P52955-1", "name": "Transcription factor LBX1", "aln": "-------------------------------------------------------------------------------------------------------------------------------MTSKEDGKAAPGEERR-RSPLDHLPPPANS----------------------------------------------------NKPLTPFSIEDILN--------------KPSVRRSYSLCGAAHLLAAADKHAPGGLPLAGRALLSQTSPLCALEELASKT-----------------------------------FKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSG-----QMDIVALAELEQNSEASGGGGG---GGCGRAKSRPGSPALPPGAPQAPGGGPLQLSPASPLTDQRASSQDCSEDEEDEEIDVDD-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P52954-1", "uniprot_id": "LBX1_HUMAN", "id": "P52954-1", "name": "Transcription factor LBX1", "aln": "-------------------------------------------------------------------------------------------------------------------------------MTSKEDGKAAPGEERR-RSPLDHLPPPANS----------------------------------------------------NKPLTPFSIEDILN--------------KPSVRRSYSLCGAAHLLAAADKHAQGGLPLAGRALLSQTSPLCALEELASKT-----------------------------------FKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSG-----QMDIVALAELEQNSEATAGGGG----GCGRAKSRPGSPVLPPGAPKAPGAGALQLSPASPLTDQPASSQDCSEDEEDEEIDVDD-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6ZM39-1", "uniprot_id": "Q6ZM39_DANRE", "id": "Q6ZM39-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------MTSKEDAKGASVEDRR-RSPLDHLPPPANS----------------------------------------------------NKPLTPFSIEDILN--------------KPSVKRSYTICGTAHLLSSGEKHPSTGHPLSNRALLTQTSPLCALEELASKT-----------------------------------FKGLEVSVLQAAEGRDGMTLFGQRNTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKAVGNVP-----FEKMAKLADLEKRVNGTLGDSS------AVSPSRSN--------HEHEGTNKLHMSPSSPYTDH-TTSKECSEDE-DEEIDVDD-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7FDX5-1", "uniprot_id": "LBX1B_DANRE", "id": "E7FDX5-1", "name": "Transcription factor LBX1b", "aln": "-------------------------------------------------------------------------------------------------------------------------------MTTIKVVKICGAMESRGLNPLDHLPPPASS----------------------------------------------------NKPLTPFSITDILS--------------KPTVKR----FHRIHRLPASDRVRQS-ITVSRQTLITQASPLCALQELASKT-----------------------------------FKGLELGVLQAAEGKDGLKLFGQRDSPKKRRKSRTAFTNHQLYELEKRFLHQKYLSPADRDQIAHQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESVRSTGLVP-----LDKLAKLADLERCAAAGATGNP-----GPQCSPRLG--------HEYKTVHKLCLSPMSSLSDH--TSQDCSEDE-EVEIDVDV-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KH37-1", "uniprot_id": "A0A0B4KH37_DROME", "id": "A0A0B4KH37-1", "name": "", "aln": "----MPQRTPSPANSDVSVG-SPSPPP-------------------------------------------------LRSLN----------MKRLRLLRS---------------PISLEHDRQKSSPVRVKSFSIADILGRG--HEEDRVEKKPER--IAIPNALPGVP---------APLALINERLQIPLVPN----------CPPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRS-QEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKIPDQSADPNRSHHNHPHYHQQHQHYAHMQSIGS-------DRDMDKDRCREKEKDKDKEELRMLKLMTLMRYSDGKLLYQQPPASYLPIPHRQNAD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q7KS77-1", "uniprot_id": "Q7KS77_DROME", "id": "Q7KS77-1", "name": "", "aln": "MLCPPTMRPASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAAAAASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLH-YEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFS-------------------AHKSFLENVN----------DLS------ILKKKPMHESDMVGLAAAAAAAG----MVVPVPGSVPMGGAPPK-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . : : .. .: .* :* : .. .: : :: :: *. *. *.* : : :: :. : :*. * ***:*********:*::*******:**********:** ***:************** ***:**:* *.:. : . . : : . :. . ", "identical_positions": 64, "similar_positions": 54, "identity": "12.31%" }, { "cls_id": "homologset.agr.HGNC:16961", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K4F0-1", "uniprot_id": "CD226_MOUSE", "id": "Q8K4F0-1", "name": "CD226 antigen", "aln": "-------------MAYVTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSFYNASEADIGIYSCLFHAFPNGPWEKKIKVVWSDSFEIAAPSDSYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRQTRSNCSQGSMKSILIIPNAMAADSGLYRCRSEAITGKNKSFVIRLIITDGGTNKHFILPIVGGLVSLLLVIL--IIIIFILYNRKRRRQVRIPLKEPRDKQSKVATNCRSPTSPIQST----DDEKEDIYVNYPTFSRRPKPRL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZS97-1", "uniprot_id": "D3ZS97_RAT", "id": "D3ZS97-1", "name": "", "aln": "MWKAVQPPEPFPEMAYLTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTDNLTQAEWTKDTGTKKVNIAVYHPNHNMHIDPNYLHRVHFQNATVGFRNMSLSFYNASEADIGIYTCLFHAFPRGSWEKKIKVVQSDSFETTAPLDSYLSAEPGQNVTLSCQLERTWLVQLVIWEKVQPHQVDILASCNLSQGTRYTSKYLRQTWSDCSQESMKSALIIPYAMAADSGLYRCRSEASTGTNKTCVIRLIITDGGTNNHFILLIVGGLASLLLVIL--ITIIIILFNRKRRRQVRTPLKELRDKQSKVATNCRSPTSPIQTT----DDEKEDIYVNYPTFSRRPKPRF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q15762-1", "uniprot_id": "CD226_HUMAN", "id": "Q15762-1", "name": "CD226 antigen", "aln": "-------------MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFK-IGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHG-RWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQ-KAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * * ***:***::*****.**.*:* ::*.*:****** ***.** * **: .**:: *.*.* * * .**:* *:*:. .**:* * **** *:* *:* ::::*.*.*:* *:** ***** :.* :*:: :***::***:** ** ** * ***:**:*:*:*: *** : .:***: ** *:**: * ::** . .:******* :* :* *:: *:** :::* *:::: * :.** . ***.:: **.*: **:***: * :.* *.* *...* *** *. *.* ** :***************.*.", "identical_positions": 166, "similar_positions": 92, "identity": "47.16%" }, { "cls_id": "homologset.agr.HGNC:16962", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P97586-1", "uniprot_id": "CGRE1_RAT", "id": "P97586-1", "name": "Cell growth regulator with EF hand domain protein 1", "aln": "-------------------MSRWLMQMLMLPLLLLPLGQAAPKDGVARLDPEAQQQLTTNPFQPGPEQLRRLRDYLKG-LEKMEEDPEQMNREQVLLYLFALHDFDQNGQLDGLELLSMLTAALAPGAAHFP-INPVILVVDMVLETQDLDGDGLMTPAELINFPGEAPKRAES---LPPALQEPQPAGSQPLLANSPLQSETQQSLGTKEEITSQVEAKRA-LEPEQE----------------------------------AGHHIETKVDALSPEGEARGQAESEGDAPGPREDAERQVESKDNEGEAKDLPAETLETQNTPNVVEAHSIQLENDEI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R1U2-1", "uniprot_id": "CGRE1_MOUSE", "id": "Q8R1U2-1", "name": "Cell growth regulator with EF hand domain protein 1", "aln": "-------------------MFQWLMQALMLPLLLLPLGRAAPKDGVARLDPEVQQQLTPNPFQPGPEQLRHLQNYLKG-LEKMEEDPEHMDREQVLLSLFALHDYDQNGQLDGLELLSMLTAALAPGAAHFP-INPVILVVDSVLETQDLDGDGLMTPAELINFP-EVPKHTES---LPPALQEPQPAGSQPLLANSPLQSETQQSLGTKEEIRGQVEAKRASLEPEQE----------------------------------AGHQTEGKVDTLSPEEEARGQAESEGDVPGPREGAEEQVEIKDNEGEAKELLVETLESLNTPNEAEAHSIQLENDEI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99674-4", "uniprot_id": "CGRE1_HUMAN", "id": "Q99674-4", "name": "Cell growth regulator with EF hand domain protein 1", "aln": "-------------------MLPLTMTVLIL--LLLPTGQAAPKDGVTRPDSEVQHQLLPNPFQPGQEQLGLLQSYLKG-LGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB40EB38-1", "uniprot_id": "A0AB40EB38_DANRE", "id": "A0AB40EB38-1", "name": "", "aln": "MDGPLTAVNSEGVLMRSRGAANMISTRLVFVLILPALTLCAP--QVQSLSDGVLAPDLANPFGSSEDNRRLLQSYIKSNLKEGQTSPELNTREQEVFFLFSLYDYDRSGQMDGLELMQLLTDFLTYHEMAPKSTDSVVTLVDYLLQTQDLNQDGLLAPSELLSPS---------------TMEHQDNIPTDPPADETSKQEETGKKPENGDAKN---------------------------------------------------HQKDAEVDQ-------------GSEHKNETDEEHKQTPEKAEEQQDQQQPPIEQKLQDDHQELENMPIHQNQPEM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q0KI91-1", "uniprot_id": "Q0KI91_DROME", "id": "Q0KI91-1", "name": "EF-hand domain-containing protein", "aln": "-----------------MYRMCNLSNLLNFIICIASFSQNFDATLAVKRGPHHPRGETRRVDQHLTHEEHRIDDDLKD--MGVQANLDDLSEEEKIFYMFKAHDNDNNNALDGLEMIQSAMHHNYDYFKNNERDAYLQNATDELEHFIEAIDKFLLIADD-----------------------NNDGLLHYPEFVKAITGGKEQPNVDRNILR-------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : . . . . .: : . :*. : . : .*: :: :* :* *... :****::. : .* : . : . *: . : . : . :: : ", "identical_positions": 12, "similar_positions": 43, "identity": "3.53%" }, { "cls_id": "homologset.agr.HGNC:16963", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7L523-1", "uniprot_id": "RRAGA_HUMAN", "id": "Q7L523-1", "name": "Ras-related GTP-binding protein A", "aln": "MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPL---ECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ---CKEQRDV----------HRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDG---PKHSLLMR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q80X95-1", "uniprot_id": "RRAGA_MOUSE", "id": "Q80X95-1", "name": "Ras-related GTP-binding protein A", "aln": "MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPL---ECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ---CKEQRDV----------HRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDG---PKHSLLMR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q63486-1", "uniprot_id": "RRAGA_RAT", "id": "Q63486-1", "name": "Ras-related GTP-binding protein A", "aln": "MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPL---ECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ---CKEQRDV----------HRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDG---PKHSLLMR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VHJ4-1", "uniprot_id": "Q9VHJ4_DROME", "id": "Q9VHJ4-1", "name": "", "aln": "-----MKKKVLLMGKSGSGKTSMRSIIFANYIARDTTRLGATIDVEHSHVRFLGNLVLNLWDCGGQEGFMKQYFAQQRDNIFRNVEVLIYVFDVESQEIERDIHYYQSCLEALLQNSPEAKIFCLVHKMDLVPEGLRESVFTERMEDLIKLSKPG---NVTCFRTSIWDETLYKAWSSIVTMLIPNVAALENSVTHFGNVIEADEVLLFEKATFLVISHCQ---SKKNRDS----------HRFEKVSNIIKQFKLSCSKLGAKFQSMEVRNSAFAAFIDTFTSNTYVMVVMSDPTLPSEATLVNIRNARKYFEELENPSNSAINHHGQRYH", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q00582-1", "uniprot_id": "RAGAB_YEAST", "id": "Q00582-1", "name": "GTP-binding protein GTR1", "aln": "-MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAKIFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVCSLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDPKRFEKISNIMKNFKQSCTKLKSGFKTLILNNN---IYVSELSSNMVCFIVLKDMNIPQELVLENIKKAKEFFQ------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :**:****:*****:*******:** * ** ************:*****:.*********: **::**:.*:*:**: *:***:****** *: :*:. : ..*: : : **:**** *:****** . *: :* ::* . * : * ******:******.** ****: : .: :* ::::* *::***::*****. : .::::* :****:***:*:** **:** : *::: :.*. ::. ::** ::*:.* .:*. .* **::*::.*: ", "identical_positions": 144, "similar_positions": 90, "identity": "43.37%" }, { "cls_id": "homologset.agr.HGNC:16964", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5Y4I3-1", "uniprot_id": "A0A8I5Y4I3_RAT", "id": "A0A8I5Y4I3-1", "name": "Dynactin subunit 6", "aln": "MAGSVTPYLASAGYGGGEGLFRDPHPSLHACADSIGAALGDSGSLRKVARRRPAVATPSILPLVRKRETWRKSLKLSSFCPVPESLGPAAMAFSVPVFTSGDRWWDETAWITEKHIEPFHLAIYRVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIIPDTEDPEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WUB4-1", "uniprot_id": "DCTN6_MOUSE", "id": "Q9WUB4-1", "name": "Dynactin subunit 6", "aln": "--------------------------------------------------------------------------------------------------------------MAEKTQK-------SVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIIIGEGNLIEEQALIINAHPDNIIPDTEDTEPKPMIIGTNNVFEVGCHSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCSLNTFEAIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O00399-1", "uniprot_id": "DCTN6_HUMAN", "id": "O00399-1", "name": "Dynactin subunit 6", "aln": "--------------------------------------------------------------------------------------------------------------MAEKTQK-------SVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q502J7-1", "uniprot_id": "DCTN6_DANRE", "id": "Q502J7-1", "name": "Dynactin subunit 6", "aln": "--------------------------------------------------------------------------------------------------------------MADPSAKQTGQK--SVKIAAGAVVCVESDIRGDVTIGARTVVHPKARIIAEAGPIVIGEGNLIEEQALIINSFPENLLPNTDDVEPKPMIIGVNNVFEVGCVCQALKIGDNNVIESKADVGRSVMLTSGCIVGSCCQIHTCEVIPENTVIYGSECLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTVKSSGTPARS-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VIZ1-1", "uniprot_id": "Q9VIZ1_DROME", "id": "Q9VIZ1-1", "name": "Dynactin subunit 6", "aln": "----------------------------------------------------------------------------------------------------------------MPSEN-------RIKILPKAVVCEESSLRGDITFSSGCVVHPSATVIADAGPIIIGENCIIEEYATVAHRLEPGAVWDVNN----ILSIGTHNVFEVGCQVEAAKIGDKNVFESKCYVGPGVTVSSGCVVGAGIKIHGSQRLPENTIVYGEQGLQREAIDKQGSQTLQIDFLRKVLPNYHHLRKPNYDPKKARSVV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :** . **** **.:***:*:.. *:**.* :**:****:***. :*** * : : . :.:: : **.:******* :* *:**:**:***. ** .* ::***::*: .:: : :****::** : *:* :: .****:*** *:*******:*. .. .. ", "identical_positions": 78, "similar_positions": 57, "identity": "25.32%" }, { "cls_id": "homologset.agr.HGNC:16966", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7FKH2-1", "uniprot_id": "F7FKH2_RAT", "id": "F7FKH2-1", "name": "Zinc finger MYND domain-containing protein 11", "aln": "MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEID-------------------WETETHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKHSNKQEMGTYLRFIVSRMKERAIDLNKKGKDSKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNVHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNE---DRGE---------EEAESSISSTSNEQLKATQEPRAKKGRRNQSVEPKKEVSCPPHSVQVAVERGKSLKVRSRQSSNIRQVKAQSPDSCRCGLLLDQHASAQSPSPEPEPETEAVSSSQEIPT-MPQPIERVSVSTQTKKLSASS------PRMLHRSTQTASDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVANMQGEMDRKCKQVKEKCKEEFVEEIKKLAAQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R5C8-1", "uniprot_id": "ZMY11_MOUSE", "id": "Q8R5C8-1", "name": "Zinc finger MYND domain-containing protein 11", "aln": "MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEID-------------------WETETHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKHSNKQEMGTYLRFIVSRMKERAIDLNKKGKDSKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNVHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNE---DRGE---------EEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKE--------------------------------------------------------EPEPETEAVSSSQEIPT-MPQPIERVSVSTQTKKLSASS------PRMLHRSTQTTSDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVASLQGDMDRKGKQLKEKCKEEFVEEIKKLAAQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15326-1", "uniprot_id": "ZMY11_HUMAN", "id": "Q15326-1", "name": "Zinc finger MYND domain-containing protein 11", "aln": "MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEID-------------------WETENHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSPWQCPVCRSIKKKNTNKQEMGTYLRFIVSRMKERAIDLNKKGKDNKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNIHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNE---DRGE---------EEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKE--------------------------------------------------------EPEPETEAVSSSQEIPT-MPQPIEKVSVSTQTKKLSASS------PRMLHRSTQTTNDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVANMQGEMDRKCKQVKEKCKEEFVEEIKKLATQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NBV5-1", "uniprot_id": "A0A8M1NBV5_DANRE", "id": "A0A8M1NBV5-1", "name": "", "aln": "MSRVVKKRQADPKVVQYVWSAIEVIRNQKQIANMDRISKYLSRVYGMHPKDTARQLVLAVKDGLVVETLTVGCKGSKAGIEQEGYWLPGDEMEQMSEGSKPSLPSEALFPDDWEAESHDWYCFECHLPGDVMECDGCFRVYHLRCVSEDHRPRDTTSHWQCGICRGSKRKNLNKQEMTTYLKFILGRMKERAVDLHKRGKEAKQPIYKRLIHTPLDVENIQENISDGKYKSFEEFRADAQLIVHNTAILHGVNSDQTEIARLLYNDTCHELNELMLCRTCFYLSNARPDNWFCYPCSPNHELVWARMKGFGYWPAKVMQREGNQVDVRFFGHQHQRAWIPSDNIQDITVSVQQLQVKRSSGWKKACDELELHQRFVREGRTWKGKPEEKNDRSERHERQEERQEEAESSISSTSNEQSRVNQEPKAKKSRRSQVAEPKEE--------------------------------------------------------EPEPEMEAVSSSQEIPTAVPHQPERMSVSTQTKKSSSPSSSSSPAPRMIHKGTQTVNEGNCQNMCHDKYSKIFSDVKEMMKAENKRETERVLKEALDKLRGEMEEEKRQAVNKAVSSTQAEMERKCKQVKEKCKEELMEEMKKMVSQHKQLLSQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHADHKRTCRRKR", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:*:.*:****.*.:*::*:***:*********:***:**:***:*****:*:*** *******:**************************:: **:*.************:*: ** ****** :*:*::.* **::* *** :**. *:*: ***** ***:**:.******:**:*:**: *:*:*:**:*:.:** .***::.:***:*:***:*****::***.*::*.:*:*::***:**:******:** **:.***************** ********:*****:*******:*.**********:********:*******.:::*:**** ***************:**** **.* * **.* ************** :..***:***.**.* .***:* ***** *********** :*: *::******** *:.* ***:*:.***..:* **.******:***.*.*: **:::*******::***:***.**************:. *.:*:** **:*******::**:**:.:*****:**************************************:*********", "identical_positions": 443, "similar_positions": 132, "identity": "63.65%" }, { "cls_id": "homologset.agr.HGNC:16967", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P56212-1", "uniprot_id": "ARP19_MOUSE", "id": "P56212-1", "name": "cAMP-regulated phosphoprotein 19", "aln": "MS-----AEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGG-SDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQ-LPAAAPDKTEVTGDHIPTPQDLPQRKPS----------------LVA--SKLAG-------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q712U5-1", "uniprot_id": "ARP19_RAT", "id": "Q712U5-1", "name": "cAMP-regulated phosphoprotein 19", "aln": "MS-----AEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGG-SDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQ-LPAAAPDKTEVTGDHIPTPQDLPQRKPS----------------LVA--SKLAG-------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P56211-1", "uniprot_id": "ARP19_HUMAN", "id": "P56211-1", "name": "cAMP-regulated phosphoprotein 19", "aln": "MS-----AEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGG-SDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQ-LPTAAPDKTEVTGDHIPTPQDLPQRKPS----------------LVA--SKLAG-------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VUB8-1", "uniprot_id": "Q9VUB8_DROME", "id": "Q9VUB8-1", "name": "", "aln": "MSSAEENSNSPATTPQDTETTEQANLTDLEKIEEEKLKSKYPSGMRVPGGHSAFLQKRLQKGQKFFDSGDYQMAKQKGGGVK-QVFAN---KVTTGEAIPTPETVPARKTS----------------IIQPCNKFPATS-----------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9P305-1", "uniprot_id": "IGO2_YEAST", "id": "Q9P305-1", "name": "mRNA stability protein IGO2", "aln": "MS--EDLSPTSSRVDLSNPHGFTKEGVDLSKLSPQELKL-YKMYGKLPSK-KDLLRHKMQD-RQYFDSGDYALKKAGVIKSDDVIVNNSSNNLPVTNPSGLRESIIRRRMSSSSGGDS----------ISRQGSISSGPPP----------------------------RSPNK", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53897-1", "uniprot_id": "IGO1_YEAST", "id": "P53897-1", "name": "mRNA stability protein IGO1", "aln": "MSN-ENLSPNSSNPDLTKLNNGESGTIDTSKFSPNEMKL-YKMYGKLPSK-KDIFKHTMQK-RKYFDSGDYALQKAGIQNND--PINYGKNNLPLTNPSKLREDIIKRRISTCPSTASTAGVVDNATLIQKEGSISSGPPSSNNGTIGGGSTSSTPVGNHSSSSSSLYTESPIR", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** : . . .* . ::* * : *. . :::: :*. :::****** : * . . : : : *: * : ..:.. ", "identical_positions": 16, "similar_positions": 32, "identity": "9.2%" }, { "cls_id": "homologset.agr.HGNC:16968", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JVX9-1", "uniprot_id": "A0A0G2JVX9_RAT", "id": "A0A0G2JVX9-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------MSEQGELTPTILEEGRTEPESA-PENGILKSESLDEEEKLELQRRLAAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESHQDQESIHLQLSSFPSLQEEDKSRKDDSE------------------------------------------------------------------REKEKDKNREKLSERPKIRMLS------------------------------------------------------------------------------KDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEMIDFIADSNNHYK-KFPQMSSYQRMLVHRVAAYFGLDHNVD-QTGKSVIINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHD-----------------------------------------------------------------------------------------------------------------SVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRDSSGRTSGSRQSS----------------------------SETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTA----------------SFGGITVLTRGDSTSSTRSAGKLSKTGSESSSSAGS--------------------------------------------------------------------------------------------------SGSLSRTHPPLQSTALTSSVAAGSPGCMAYSENGMGGQVPPSSTSYILLPLESATGIPPGSILLN------------------------PHTGQPFVNPDG-----------------------------------------------------------------------------------------------------TPAIYNPPGSQQTLRGTVSGQPQQ-PPPQQPSPQPQQ---QVQAS-----QPQMTGPLVTQSVQGLQPSSQSVQYPAVSFPPQHLLPVSPTQHFPLREEMAAQFSQLSMSRQSSGDTPEPPSGPVYPASLM-QAAQP-------------------------------PSYVITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTTQQYRPLASVQYSAQRSQQIPQTAQQAG---------------YQPVLSGQQSFQG---LMGVQQSAHSQGVMSSQQGAPVHGVMVSYPT--------------MSSYQVPMTQGSQAVPQQTYQPPIMLPSQTG---QGSLPATG----------------MPVYCNITPPSPQNNLRLMGPHCPSSTVPVMSASCRTNCGSMNNAGWPVKF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DCB4-1", "uniprot_id": "ARP21_MOUSE", "id": "Q9DCB4-1", "name": "cAMP-regulated phosphoprotein 21", "aln": "----------------------------------------------------------------------------------------------------------------------------------------MSEQGGLTPTILEEGQTEPESA-PENGILKSESLDEEEKLELQRRLAAQNQERRKSKSGAGKGKLTRSLAVCEESSARSGGESHQDQESIHLQLSSFPSLQEEDKSRKDDSE------------------------------------------------------------------REKEKDKNREKLSERPKIRMLS------------------------------------------------------------------------------KDCSQEYTDSTGIDLHGFLINTLKNNSRDRMILLKMEQEMIDFIADSNNHYK-KFPQMSSYQRMLVHRVAAYFGLDHNVD-QTGKSVIINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDKEDNQ-NRMHPFRDDRRSKSIEEREEEYQRVRERIFAHD-----------------------------------------------------------------------------------------------------------------SVCSQESLFLDNSRLQEDMHICNETYKKRQLFRAHRDSSGRTSGSRQSS----------------------------SETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTA----------------SFGGITVLTRGDSTSSTRSAGKLSKTGSESSSSAGS--------------------------------------------------------------------------------------------------SGSLSRTHP--QSTALTSSVAAGSPGCMAYSENGMGGQVPPSSTSYILLPLESATGIPPGSILLN------------------------PHTGQPFVNPDG-----------------------------------------------------------------------------------------------------TPAIYNPPGSQQTLRGTVGGQPQQ-PPQQQPSPQPQQ---QVQAS-----QPQMAGPLVTQ-----------------------------------REELAAQFSQLSMSRQSSGDTPEPPSGTVYPASLLPQTAQP-------------------------------QSYVITSAGQQLSTGGFSDSGPPISQQVLQAPPSPQGFVQQPPPAQMSVYYYPSGQYPTSTSQQYRPLASVQYSAQRSQQIPQTTQQAG---------------YQPVLSGQQGFQG---MMGVQQSAHSQGVMSSQQGAPVHGVMVSYPT--------------MSSYQVPMTQGSQAVPQQTYQPPIMLPSQAG---QGSLPATG----------------MPVYCNVTPPNPQNNLRLMGPHCPSSTVPVMSASCRTNCGNVSNAGWQVKF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UBL0-1", "uniprot_id": "ARP21_HUMAN", "id": "Q9UBL0-1", "name": "cAMP-regulated phosphoprotein 21", "aln": "----------------------------------------------------------------------------------------------------------------------------------------MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSE------------------------------------------------------------------REKEKDKNKDKTSEKPKIRMLS------------------------------------------------------------------------------KDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEIIDFIADNNNHYK-KFPQMSSYQRMLVHRVAAYFGLDHNVD-QTGKSVIINKTSSTRIPEQRFCEHLKDEKGEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHD-----------------------------------------------------------------------------------------------------------------SVCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSS----------------------------SENELKWSDHQRAWSSTDSDSSNRNLKPAMTKTA----------------SFGGITVLTRGDSTSSTRSTGKLSKAGSESSSSAGS--------------------------------------------------------------------------------------------------SGSLSRTHPPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSILLN------------------------PHTGQPFVNPDG-----------------------------------------------------------------------------------------------------TPAIYNPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQ---QVQPP-----QPQMAGPLVTQ-----------------------------------RDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQ-------------------------------PSYVIASTGQQLPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTSTTQQYRPMAPVQYNAQRSQQMPQAAQQAG---------------YQPVLSGQQGFQG---LIGVQQPPQSQNVINNQQGTPVQSVMVSYPT--------------MSSYQVPMTQGSQGLPQQSYQQPIMLPNQAG---QGSLPATG----------------MPVYCNVTPPTPQNNLRLIGPHCPSSTVPVMSASCRTNCASMSNAGWQVKF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R9YJI6-1", "uniprot_id": "A0A2R9YJI6_DANRE", "id": "A0A2R9YJI6-1", "name": "", "aln": "----------------------------------------------------------------------------------------------------------------------------------------MSETG--------ESENLPECTMEETSPQCCTTNTEDCQKSSQPKSEDNHEQLTKKQK--NKGKLIRSVAVCDESVSTD--ENSKEKDSK----TSISSNHG-DSPVCDEVE------------------------------------------------------------------EEK---------SITSKKTSLS------------------------------------------------------------------------------KEPSLEYTDSTGIDLEEFLITTLRSSPRDRLMLLKLEQDMTDFMTD-NSSYK-KFPQMSSYHRMLVHRVAAYFGLEHNVD-HSGKAVIINKTCSSRIPEHRFAEHVQEEKMEE--RRLILRRDAS-QEKEDGQ-LRVPSLKEQMRSRSIEEREEEYQRVRERIFSQD-----------------------------------------------------------------------------------------------------------------ATCLSQSVYIET-RGPDDGSVLTETQRRRQLFRGERDGSGRLSGSRQSS----------------------------FELDCHWNNDPRPWSSTDSDSPTWSSK----------------------------SAHTRSDSSS------KLCKPAVSDSALSYA--------------------------------------------------------------------------------------------------PSNNNNNNP-----------------------------------TYIIVPAESS--IPPGSILLN------------------------PHTGQPFLNPDG-----------------------------------------------------------------------------------------------------TPAVYNPPVSQKSSIQLNPVQPQAPPPPPQQQPIVSHGVPQVQYSSVSYLPPQQMNASTSQQLP----------------------------VEQTSEDISAKFAHMTLSHQSSADPPE------MSSFYMQGAPPT-------------------------------NTYAPHLHSYAPSHQSESYMSPGMTLAPPTAPPP-----QNQQSSQVSVYSYP--VQCASASQQYTAAA--------------YGTQTG---------------YQPVVSNQQGCLG---MMGSQVLPQTQ-----------QGIMGAYSS--------------VTSYQVPHHHQQQ--QQQQHPSAMLVSGQGGQT-QCMVPPAG----------------VQLYCNSPPPS----LSMMG-------VSFQSSSCKNGCNVNQNQCWY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8MSX1-1", "uniprot_id": "ENC_DROME", "id": "Q8MSX1-1", "name": "Protein encore", "aln": "MSSTKSQVALATNIPTNLSSAASASTAAAAAAVVVVASANAAVASSANSSGVGSGSGPGPGSGAGVSGPVAAGTATAVATGSTVTAATSVAATTSTSVATISTSCSSSSINNINNNCGEECQSAAGSSNLGRQNSFGNRRGNMKGKHLTRSHAMRESTSPPRTPTPRAASEQQQQQLQGEQHEHNNNNNINSSSKAQSAGRGNSPLMETPAVIVTSQQPQQQQQQQQQQQQSVPPKPQQNVPLSNEAEFPKLSPPKKSGGQHNRTNSNGSGMEFNNNNNSSNKKFVVDMKANGLDNKPHNNSSTGVIFNSGMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHRANTNAKGNKPRLKNLGGSSSGSIDLGGGGGNGNCNNMSNNGQSNNSSNNTSGFISRENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRMLIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFDEVRQS-PYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQQQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRSGGAVPKSHNFGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGSIYHYDPSNLPPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSSTESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPGATTVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPIQYSYPYYHPISYYVPQQAVAAAPMVASQPQVGQAPMQQQAPHTGAGTTTGPPTVVSVSGQQHHQPHQQHHQQQQHSSNGSVVTSSAYGTRVKRTPGGGSIHYNPSYTPSSVAHAGGAHHPSAGSAQIIAAPAASTTTYHALPTLTLAHGGPATGTDLSGAGGAHVYALPAQHALIPTNIFPYAAAAAAAAGGPGGPPTTPQVVQQAPPPPPQSAPHHALITAAPFYPANGGNMDQGASQSAPSTPAAPGRQAPLFSTPPAPNNGSSGSSSAGGGGNSGGYHSNSSTPHYYQGQNSNEGYTSPYEKRNHGGGASGAHSVGVRKPYHPGGYNPRHSVPLGGIPSGAKTPLLNSNNEPTPRASPSSVSLGGASSSGGANSYPHRGPPPHTMGVKRDNKPNQLPLISGPPPSYAANSSPGVSSYESKPPVRLNAGAASFRSQKSMNQDYRRSVSQRNSPSANGGGSGSHESSNNSPNSIVGSQSNSAANTPNAAAPPPPQPQPTLVSHSGGFVVLDQTTGAAMNASPPSLYGGGGGPNAGISGGAGASGAAGSNGGHQPGGGGGARSHIPTAQLHHSAAAAAAAAAGSQQATAAVLSGVAAAAALGGYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSNDIRPQMAQVAGMYPTMMIQARHPSRHPNPNYKGSRPR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. * .. * : : :: : : :::: :... .. .* : : : ::::. *... : . :: * . . .: ** :: * :*** * ** *: **....:** :***:*::: **: : . : :** ***:***:**.**:**::**** .: :.**: : .:**** ** . :::: :: **:** :: . : .: : :::*:*****:*:*.*.***:: : . . *:: .: .: * . ...** .. *:** : . :: . ***:* : . :. *:.*. . . . *: . . .* :* * : :* * : * : * .*:. * * * . . *.* . * .. . . * * . .:...: :::.*. ..: .: . : . . . . * . .**. : . : . . :.* . : : * *:. * : * * ..: .: .* . :. :.* : .: : .: : . . * * : : .. .*. :. * . :.:. . * : ", "identical_positions": 114, "similar_positions": 224, "identity": "6.25%" }, { "cls_id": "homologset.agr.HGNC:16969", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q66HA8-1", "uniprot_id": "HS105_RAT", "id": "Q66HA8-1", "name": "Heat shock protein 105 kDa", "aln": "---------------------------MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQAVPY-PEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIP---DADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCG-PYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPRVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQDPVVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNMDKKE-DLEGKSNLGADAPHQNGECHPNEKGSVSMDLD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61699-1", "uniprot_id": "HS105_MOUSE", "id": "Q61699-1", "name": "Heat shock protein 105 kDa", "aln": "---------------------------MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPY-PEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTP---DADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCG-PYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNIDKKE-DLEGKNNLGAEAPHQNGECHPNEKGSVNMDLD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92598-1", "uniprot_id": "HS105_HUMAN", "id": "Q92598-1", "name": "Heat shock protein 105 kDa", "aln": "---------------------------MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPY-PEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENE-MSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIP---DADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCG-PYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB40EBT1-1", "uniprot_id": "A0AB40EBT1_DANRE", "id": "A0AB40EBT1-1", "name": "Heat shock protein 105 kDa", "aln": "MTDAYTHGFVCPSDLSTLLAVPSRVRDMAVVGFDVGFQNCCIAVVKSGGIETVSNEFTDRCTPSVISFGSKNRAIGNAAKNQMITNPSSTVFHFKRLHSRLYHDKVVQAEKANLPYDLVPLNDGKVGVQVMYLDQEHHFSIEQISAMLLTKLKDIAEANLQKKVLECVISIPSFFTDSERRSVLDAAKIAGLNCLKLMNDSTAVALNYGIYKEDLPGSDENPKIVAFVDLGHSAFQVSICAFNRGKVKVLSTAFDPYLGGKDFDQRLVDHFCAEFKSKYMMDVKSKTRALLRLTQECEKLKKLMSSNSTELSLNIECFIDDKDVCGRMNRAKFEEMCADLIERVKFTLMKAVEQAGVRLQDISAVEIVGGATRIPAVKAQISSFFRRDVSTTLNADEAVARGCALQCAMLSPAFRVREFSITDVIPFPISLSWSSEADEGKSCHEIFSRNHPCPSAKMITFYRNKPFILEAFYSDKSSLPF-PEAKIGEYKVQNIQPQENREKAKVKVKVEVNRSGVVSVSSAAVVLRVRSDESEITEINEDVDS------HDASDDTDVQDKTEEVNIELSVNKENLPTAQCPPMEKEQNQRETLS---MNGEVN----SHPPHAKKAKMKVKHVVLPMEETFNQQLPKDRLSAYTEQENKMIQQDRQEKERNNAKNAVEENVYYFRHKLEG-SYQTFLNAQEHQAFSELLNGTENWLYDEGADQDKQTYINRLAEIHKLGLPVENRYRESIRRPRMFEELSAKIQSYMTIVEDYKNGSESYCHIDAMDMDKVRVCVKDTQVWMTNIQDSQDKLTPDQEPAIHSTQIQKKLQTLNNVCGEIVSKPKPRVDSP-MDDTIQPERLHKHK--------SPEDVTMDYTDFVQNERKNNHVNI-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9MSL3-1", "uniprot_id": "M9MSL3_DROME", "id": "M9MSL3-1", "name": "", "aln": "---------------------------MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPY-PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE-------KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSG------------ADKKKKASKATELPLECTTHGFSPVD-LSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQN-GGEPAANSGDKMDVDN-NGQSAAGNDPSMEVE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32589-1", "uniprot_id": "HSP7F_YEAST", "id": "P32589-1", "name": "Heat shock protein homolog SSE1", "aln": "--------------------------MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVAFVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKKVLSAN-TNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKFEDIHPYSVSYSWDKQVED-EDHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQLPPNTPEQIANWEITGVQLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIEVEEPIPLPEDAPEDA-------------------------------------------------------------------EQEFKKVTKTVKKDDLTIVAHTFGLDAKK-LNELIEKENEMLAQDKLVAETEDRKNTLEEYIYTLRGKLEE-EYAPFASDAEKTKLQGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRGRYLAKE------EEKKQAIRS------------------------------------------------------------KQEASQMAAMAEKLAAQRKAEAEKKEEKKD-----------------------------------TEGDVDMD", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P32590-1", "uniprot_id": "HSP79_YEAST", "id": "P32590-1", "name": "Heat shock protein homolog SSE2", "aln": "--------------------------MSTPFGLDLGNNNSVLAVARNRGIDVVVNEVSNRSTPSLVGFGPRNRYLGESGKTKQTSNVKNTVENLKRIIGLKFKDPEFDIENKFFTSKLVQLKNGKVGVEVEFGGKTHVFSATQLTAMFIDKVKHTVQEETKSSITDVCLAVPVWYSEEQRYNIADAARIAGLNPVRIVNDVTAAAVSYGVFKNDLPGPEEKPRIIGLVDIGHSTYTCSIMAFRKGEMKVLGTAYDKHFGGRDFDRAITEHFADQFKDKYKIDIRKNPKAYNRILIAAEKLKKVLSAN-TTAPFSVESVMDDIDVSSQLSREELEELVEPLLKRVTYPITNALAQAKLTVNDIDFVEIIGGTTRIPVLKKSISDVFGKPLSSTLNQDEAVAKGAAFICAIHSPTLRVRPFKFEDIDPYSVSYTWDKQVDD-EDRLEVFPANSSYPSTKLITLHRTGDFSMKAVYTHPSKLPKGTSTTIAKWSFTGVKVPKDQDFIPVKVKLRCDPSGLHIIENAYTTEDITVQEPVPLPEDAPEDA-------------------------------------------------------------------EPQFKEVTKTIKKDVLGMTAKTFALNPVE-LNDLIEKENELRNQDKLVAETEDRKNALEEYIYTLRAKLDD-EYSDFASDAEKEKLKNMLATTENWLYGDGDDSTKAKYIAKYEELASLGNIIRGRYLAKE------EEKRQALRA------------------------------------------------------------NQETSKMNDIAEKLAEQRRARAASDDSDDN-----------------------------------NDENMDLD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .*:*.* :.. :*..: **: : *: : *.***.:.*. ::* :* :.*.: :: ..** :**: . ::. .: * :. : : * :* : .: : *. *::**:: *:*. : : : :: * :::: :* : ***:*.*** ::::*: **..: **.:* ** :::*: : :**:***: * ** :*::*:*.:: * :**:::* : ::*. :*: :* :: : : :* *: ***** :*:* * .:.:*..::* **.. :.* ::**: ::::: .. : :: : ::: :**:**::*** :* * * : *:*** ***:::*.*: **: **:.:** * . * :.:. *. : . . *:*. . * ::::*: * * : * :* . *. : . .:. : : **:*:. : *: :. * :* : : .: . * : . *. : *.:: :*: * : **::** :* :* ** : : :: : * *:*** :* * : * : : . :. * :* : : . : : : :.. . ::: ", "identical_positions": 147, "similar_positions": 239, "identity": "16.5%" }, { "cls_id": "homologset.agr.HGNC:1697", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P10247-1", "uniprot_id": "HG2A_RAT", "id": "P10247-1", "name": "H-2 class II histocompatibility antigen gamma chain", "aln": "----------------MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPLSMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVN-YPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTKCQEEVSHIPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDPSSGLGVTKQDMGQMFL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P04441-1", "uniprot_id": "HG2A_MOUSE", "id": "P04441-1", "name": "H-2 class II histocompatibility antigen gamma chain", "aln": "----------------MDDQRDLISNHEQLPILGNRPREPE-RCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKVLTKCQEEVSHIPAVYPGAFRPKCDENGNYLPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDLSSGLGVTRQELGQVTL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P04233-1", "uniprot_id": "HG2A_HUMAN", "id": "P04233-1", "name": "HLA class II histocompatibility antigen gamma chain", "aln": "MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQK-PTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **********:****:**.*. ** .*.**.***..*:**:************************:********.*******..**** *********:.:.*. : .*::*.*******:******* .:.*:: ** ***:*****:****:*: ::**:*****::*******::***:* **::**************** *:**:***********:****:** **************:*:***:*****.*::** *******:*::* : :", "identical_positions": 204, "similar_positions": 60, "identity": "68.69%" }, { "cls_id": "homologset.agr.HGNC:16970", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q52RG8-1", "uniprot_id": "FRS3_RAT", "id": "Q52RG8-1", "name": "Fibroblast growth factor receptor substrate 3", "aln": "MGSCCSCLDRDSVPHNHPTKFKVTNVDDEGVE----LGSGVMELTQSELVLHLHQQEAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQDLMQCN-SINVTEEPVIITRNSHPQELDLPRGSSQP--TGYTVSSFSNGFPGCPGEGPRFSSAPRRPSTSSLRHPSPGEESTQTLIASDEQSHTYVNTPTGEED-RRSRHCLQPLPEGRVPFPPQTQVSD----------------------QRDPQVFLQPG--QVKFVLGPTPARRQVMK---------------CQSLCPSMQDPPLHNNN-EGPSECP------------AQPKCTYENVSGGLQQGAGWRLSPE----------------------------------------------ERGWSGLAHRRAALLHYENLPPLPPVWESQVQQLRGEAGDDGDSKDGLTPSSNG-------FPDGEEDETPLQKPTS----TRASARSHS---SFPVPLTRRRGSP----------RVFNFDFRR----------------PGPEPPRQLNYIQVELKG---------WGTAHPKGPQNPSVSGAPGPTPHPARSSDSYAVIDLKKTVAMSNLQRALPRDDGTVRKTRHNSTDLPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WJ0-1", "uniprot_id": "FRS3_MOUSE", "id": "Q91WJ0-1", "name": "Fibroblast growth factor receptor substrate 3", "aln": "MGSCWSCLDRDSVPHNHPTKFKVTNVDDEGVE----LGSGVMELTQSELVLHLHQREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEDIFNLLQDLMQCN-SINVTEEPVIITRSSHPPELDLPRGPPQP--AGYTVSGFSNGFPGCPGEGPRFSSAPRRPSTSSLRHPSPGEESTHTLIASEEQSHTYVNTPTGDED-GRSRHCLQPLPEGRVPLPAQTQGSD----------------------QRDPQVLLQPG--QVKFVLGPTPARRQVMK---------------CQSLCPGMQDPPHHNNN-EGPSECP------------AQPKCTYENVSGGLQQGAGWRLSPE----------------------------------------------ERGWSGLAHRRAALLHYENLPPLPPVWESQGQQPGGEAGDDGDSRDGLTPSSNG-------FPDGEEDETPLQKPTS----TRASARSHS---GFPVPLTRRRGSP----------RVFNFDFRR----------------QGPEPPRQLNYIQVELKG---------WGTARPKGPQNPSVSGAPGPTPHPVRSSDSYAVIDLKKTAAMSDLQRALPRDDGAVRKTRHNSTDLPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43559-1", "uniprot_id": "FRS3_HUMAN", "id": "O43559-1", "name": "Fibroblast growth factor receptor substrate 3", "aln": "MGSCCSCLNRDSVPDNHPTKFKVTNVDDEGVE----LGSGVMELTQSELVLHLHRREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQDLMQCN-SINVMEEPVIITRNSHPAELDLPRAPQPPNALGYTVSSFSN---GCPGEGPRFS-APRRLSTSSLRHPSLGEESTHALIAPDEQSHTYVNTPASEDDHRRGRHCLQPLPEGQAPFLPQARGPD----------------------QRDPQVFLQPG--QVKFVLGPTPARRHMVK---------------CQGLCPSLHDPPHHNNNNEAPSECP------------AQPKCTYENVTGGLWRGAGWRLSPE----------------------------------------------EPGWNGLAHRRAALLHYENLPPLPPVWESQAQQLGGEAGDDGDSRDGLTPSSNG-------FPDGEEDETPLQKPTS----TRAAIRSHG---SFPVPLTRRRGSP----------RVFNFDFRR----------------PGPEPPRQLNYIQVELKG---------WGGDRPKGPQNPSSPQAPMPTTHPARSSDSYAVIDLKKTVAMSNLQRALPRDDGTARKTRHNSTDLPL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F020-1", "uniprot_id": "E7F020_DANRE", "id": "E7F020-1", "name": "", "aln": "MGSCWSCLYRDAIQDNHLNKFKVTNVDDEGNE----LGSGTMELTQTELILHTRKRDAIRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQELMQCN-SINVVEEPMIMTRPGHAPEMDMPRTPQTPNTPAFPMQGFPN---GYPG----------YPISADSSQPSLTNDHRHSLMGLDDQTHTYVNTVGMETD-LSSRHCVHSLPEVRPATYPEATTTTTTIRGGPIPGQPGMHCCPLDDPHKDPQVFLQPGAQEVKFMLGPTPAQRHLMERDRERHVPHSLRAPDGSSETEGEETPPVHMCNTHSYHHCHHLMHRHPSMEPCPESQLTYENING-LRGARRQRLSPSTVSQSQSLGSSSSSSTTGDSRTHTHPHSLPLTHTHTSSLPPQGYGCDRGMVAAGHRRTALLNYENLPSLPPVWEYRALQREEEEDQDEDEDEDEYEEEEEEEYDEYEYSEGPATPNGYHQESGGGGIHRDALQNYVNTEQLPPPTRLRHACPPHPHPPERANRVFNFDFRRQRAGRGSSICEQHSRHPPPPPSRQLNYIQVDLEGEPSGCSGHSGGAPVPQRPPPLKRGMAAAAAPPSSRRGECYAVIDLKKTAAMSNLQKALPRDDGTSRKTRHNSTDLPL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLL4-1", "uniprot_id": "Q9VLL4_DROME", "id": "Q9VLL4-1", "name": "IRS-type PTB domain-containing protein", "aln": "MG-CITSSSKLNELRGHENVFRVRVAHLQPTPGTPIIRSGYLELTPRELIFQSPGCEPIVWALQHLRRYGLNNDLFSFEAGRRCMSGPGIYTFRVHNAEQLYPMFQRYINAVNTDAFVQGERERVNSAHSVSVNMGRTEGNNYLEPAPLMSRQLG------------NFHSEPSSTSASYPLQANDSQVDDSPPNLQSPVLIPSAYLDQPLRALQDCCLEG--------------------------------------------------TASDLLSTPPSGNRLTS------------------RRRTMDLPPLESAPAPAPVLSP------------NDAVHMYANVEALIFDLNN----------------------------------------------------ERCYENVNRLELPLLPREPISNQEPATPTSLAGSCGVNYIVLDLDQPRS-------------PVGPAGSSKAINGFG----SGLSLISTP--AAVTAPVTPEAGTT--------------LDVPP-----------------PPMQTQSLNSISADTGDT------QAKKVTECSGTQGYSTIDFIRTYALNKSSTELPETVTHRQHSSHDAEELRITRHSKCIRKAYSISE----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * :. : .* . *:* .. : : ** :*** **::: :.: *. ***** :.:*****:**** :* **::*: .**::: ::* ::. : . : .. .*. .::: * .: . ::. * :: : *: . : : : :.* .. :*...*: .:: . . ** . . . :. * *: . : : : . .** * :. *. * : . * . : . : . .. * . . . :*. * .:.** *..: . . . . . . : .: :: : . : :.*.. **: * ", "identical_positions": 62, "similar_positions": 128, "identity": "9.58%" }, { "cls_id": "homologset.agr.HGNC:16971", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A9E6-1", "uniprot_id": "A0A8I6A9E6_RAT", "id": "A0A8I6A9E6-1", "name": "", "aln": "----------MLTWSSEEAMGSCCSCPEKDTVPDNHRNKFKVINVDDDGNE----LGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNSHQTELEVPRTPRTPTTPGLGAQSLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQV--HTYVNTTGVQEERKNRASVHIPPEARVSNAESNTPKEEPSNTEDRDPHVLLKPEGVKFVLGPTPVQKQLMEKEKLEQLGK----------DQVSGSGASSTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNN----LDPMHNYVNTENVTVPASAHKIDCSRRRD-CTPTVFNFDIRRPSLEH--RQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRR-TELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C180-1", "uniprot_id": "FRS2_MOUSE", "id": "Q8C180-1", "name": "Fibroblast growth factor receptor substrate 2", "aln": "-------------------MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNE----LGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQV--HTYVNTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGK----------DPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNN----LDPMHNYVNTENVTVPASAHKIDYSKRRD-CTPTVFNFDIRRPSLEH--RQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRR-TELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WU20-1", "uniprot_id": "FRS2_HUMAN", "id": "Q8WU20-1", "name": "Fibroblast growth factor receptor substrate 2", "aln": "-------------------MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNE----LGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQV--HTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGR----------DQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNN----LDPMHNYVNTENVTVPASAHKIEYSRRRD-CTPTVFNFDIRRPSLEH--RQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRR-TELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z5Y5-1", "uniprot_id": "A0A8M6Z5Y5_DANRE", "id": "A0A8M6Z5Y5-1", "name": "", "aln": "-------MAGWVQWCVKGAMGSCCSCPDKEIIPDNHHNKFKVINVDDDGNE----LGSGVMELTEEELILHTRKRDAVKWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEEIFNMLQDIMHNNSISVVEEPVLEP-------ELPATPHTPTTPGYSVPTVANGISRYPLF-DASSRPSSRHPSVGSTRLPSVGEESTHPLLLNDETV--HTYVNTTGLQEERRCRSTGHTPLEPETSNHESAVP----ASPNEQEPCVVLEPESVKFVLGPTPVQRQRQQQETGEEATNSEHTSYTPPVKTVNGNAGLMADCDTGYDSDERKETS------CEHHNGIST----GARRIRPP-VPLPDAHNANNSAQRRTALLNYENLPALPPVWEMRKPEEDE-----LKSPSLNGFHS-----LDPQHNYVNTENVTVPLSAHKHNSQ-------PSVFNFDLRRLGVGDPLRQLNYIEVEMDKVSDSSGPHTPKTPTTPLPATPTRR-TELYAVIDIERTAAMSSLQKAQPRDDGTSRKTRHNSTDLPM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1Q5H9-1", "uniprot_id": "F1Q5H9_DANRE", "id": "F1Q5H9-1", "name": "", "aln": "MNQEPWWLDLGIKWS-EEAMGSCFSCPDKESIPDNHQSKFKVVNVDDDGNE----LGAGIMELTEDELVLRTRKCDAVKWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNMLQDIMHNNSISVVEEPVFEPTLTQAEPDLPLTPHTPTTPGSMLPALPNGSLRYPSLGDAPSHPSSRHPSVGSSCLPSLGEESTHPLLAAEEAVRGHTYVNTSGLLDQHS-PSISDAPAELNASSPDGEEP--VPQEAPDPGPRVQIEPEGVRFILGPTPVQRQR-QKEATQSTGD----------EEATNGSIVSQPKNTDTAEITKLDEP------SPEVSALSR------RRSRPP--PLTPDANANNSAQRRTALLDYENLPALPPLREHPKGGSED------EDQPINGFHNHRQYSPDPTHYYINTENVTAPLSANKVESARWRDRSTPTFFNFDFRRPCLES--HKLNYIEVETETE-NSSNPQTPKTPTSPLPQTPTRR-TELYAVIDVERTAAMSSLQKALPRYDGTSRKTRHNSVDLPM", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLL4-1", "uniprot_id": "Q9VLL4_DROME", "id": "Q9VLL4-1", "name": "IRS-type PTB domain-containing protein", "aln": "-------------------MG-CITSSSKLNELRGHENVFRVRVAHLQPTPGTPIIRSGYLELTPRELIFQSPGCEPIVWALQHLRRYGLNNDLFSFEAGRRCMSGPGIYTFRVHNAEQLYPMFQRYINAVNTDAFVQ-----------GERERVNSAHSVSVNMGRTEGNNYLEPAPLMSRQLGNFHSEPSSTSASYPLQANDSQ----VDDSPPNLQSPVLIPSAYLDQPLRALQDCCLEGTASDLLSTPP----SGNRLTSRRRTMDLPPLESAPAPAPVLSPNDAVHMYAN----------------VEALIFDLNNERCYENVNRLELP------------------------LLPREPISNQEPATPTSLAGSCGVNYIVLDLDQPRSPVGPAGSSK---------AINGFGSG-------LSLISTPAAVTAPVTPEAGTTLDVPP---PPMQTQSLNSISADTG-------DTQAKKVTECSGTQGYSTIDFIRTYALNKSSTELPETVTHRQHSSHDAEELRITRHSKCIRKAYSISE----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * :...* .*.. *:* .. : . : :* :*** **:: : :.: * ***** :.:*****:**** :* **::*: .**::: *:* :: . ... : : . : :.. *. . . : . .** *: * .::* :. :: * .. :: : . * .*. . * :. :. .*:** . . : . : : . . . . . :: .. ::* * * .. .:**: . .. **.* :.. *.. . .:. :.: . :....: .* . : .: *** .: .: :: . : .* . **: * ", "identical_positions": 66, "similar_positions": 137, "identity": "11.98%" }, { "cls_id": "homologset.agr.HGNC:16973", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z2E4-1", "uniprot_id": "PPR17_MOUSE", "id": "Q9Z2E4-1", "name": "Protein phosphatase 1 regulatory subunit 17", "aln": "MSTEMMTTEPVPPLELSDDILGKLDPQCSPSDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPAVHIPPFIPGVISEHLIKRYDVQERIPKAKSGPALHNSDMEQKRPRRKDTPALHMPPFVAGLTLLRDESAGVILEDEEMDGDKLAI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O96001-1", "uniprot_id": "PPR17_HUMAN", "id": "O96001-1", "name": "Protein phosphatase 1 regulatory subunit 17", "aln": "----MMSTEQMQPLELSEDRLDKLDPRCSHLDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B9T2-1", "uniprot_id": "A0A8M2B9T2_DANRE", "id": "A0A8M2B9T2-1", "name": "", "aln": "-----------------------MSTDCVR------------SLSDKAEHTLTMHEHLYEMDNQK----------------------------HVAEEHQQGK---------LGQKKPRRKDTPVLNSPPLLPGVRLMKTEARMIHQEDEEKEMKK---", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. * .*..*..: .:: * .:** .* *. :.* : **:*******.*: .*: .*: *:: * **:* : .* ", "identical_positions": 27, "similar_positions": 31, "identity": "16.98%" }, { "cls_id": "homologset.agr.HGNC:16974", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZYJ1-1", "uniprot_id": "A0A8I5ZYJ1_RAT", "id": "A0A8I5ZYJ1-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQSSPSPAHPQLPILQTQMVSDGMTGSNPVSPASSSSPASS---------GAGGISPQHIAQDSSLDG-----------PPGP-----QDGTTVPLEGFSLS--HAADPINRG----------------------------------------------------------------------------------------------------------------------------------------------PKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLASSKAGSSPCLGSSSAASSPPPPVSRLDDEDGDFQPQEEEEEDDEETIEVEEQQEGNDAETQRREIELLRHEGELPLEELLRSLPPQLLGGPFSPSQTP-SHDSDTPDGPEENIEEEPSQDLEVDPPSSSVTQCNKQCWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAYDASAPGSGNSEDEEEVEANSSDCELEETRDVEEAAQEDSSSQSDSAEEHSEDEEDEHSEEE-MSGSSQSEESESDESEDAQSQSQADEEQEDEG------DDDDDDFGVEYLLARDDERSEVDGGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHR---------EFKEWFSNPLTGMIEGSQEYN-----EGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATEVHPLQQIDMGRFDLIGLEGRVSRYEADTFLPRHRLSRRILLEIATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNSPRAPLGPVPVRPPPGPEVSTQPTLGPVPPVLPTPLMVSASPAGTPVVPASRPPGPVLLSPLQPNTGPLPQVLPSPMGVMSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSSLLKPLTVPPGYTLSPVAATTTSSTIATVTTTAVPAPNSTPQRLILSPEMQARLPSGEVVSIGQLASLAQRPVTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLP-STPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPSSSGLPAVLTPRPTLTPSRLTSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAAPMTISSSLHMPSSLPGPASSSMTIHNSSPLSSPVVSSTVSVPVSSSLPISVPTTLPVPASAPLTIPITAPLPVSDLGPALLTGVTPALA-VVSAASGPP-LASAGVSPSVSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVPASALTSPFPISPSSAPAQASLLAPAPSTSQALATSLAPMAASQTTILGPSPTPPLAPLPVLAAS----------QTPLPAMTPPSMSGAPLPSSTLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLA------PSSPVGPAPAHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVPTLDPSATQTLALAPALTQAPASQASSLVS-ASGAASLPVTMVNRLPVPKDEPETLTLRSGPPSPLPTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKQQRSERLERIFQLSEAHGALAPVYGTEVLDFCT-LPQPVASPIGPRSPGPSHPIFWTYTEAAHQ--------------AVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPHQAAFQEQLACELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPPGSSVSSV--------------PEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENEGFPAGEGEEASRPGPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDEMSCATSGVSHRRSKKVKAPERLGTRVSERLRGARAETQGANHTP---------VTSSHQTCNTFVPPRCSPVRERIPR-----PRPAPPPAPPAPPPAASPAPAPAPAPPAPPPPVLPPVLPPVPPPPPAPSPPAPSPAPPPPAPAASVASAPASAITSSLATAPIP-------------------ISAPNPVTILPVHILPSPAPLLQLPPCSSPASTPP----------------------------------------------------------------------------SACTPLPTCTPLPAQTSLLTSSSPAPLDS--LPVPISPGVTN--------------------------LLLDSG-EVEVCTQELAP---------------VESLELPGMTNSEASLVS-------LVPPNDLLPVAVDVLPESEKNLPLIP-----APSSTLEAESIPDDQEQEVPGSVEGTNRTLLPGGGELTVSLSESNGLELP----------PSAASDEPL-QLLETHRNLED------TREVQTPVSNSEKPQELVRAEVTAPSTSSSATSSPEGPLPARPPRRRTSADVEIRGQGS------------------------GRTGQPPGPKVLRKLPGRLVTVVEEKELVKRRR-HRATASTLVPG------------------------------VSEVSASPRSPSIHSMSGPESS-----PPSSGPCEAAPTSSLSTPTQHTFIACRHNELG----ITGGGSPENGEGAKLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPS---------SISKGKTNGVDPIPGPETVTATAAEPDLK--------------------------PQPLAPQPVHK----PEPIILSPVEKRRRGRPPKARDLPIPGTISSPGDGNLESRTQPLPFPATLT---------------PLLACPTA-VANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ--HPVLDPDSSSVLESCGLGVQRQPLGQAESEGSSSDEDGS----RPLTRLARLRLEAEGMRGRKSEGSMVMAVIQD----------------------------------------------------------------------------------------------------DLDLADSGPSGLELTPPVVSLTPKFRSTRLRPGSLVPPLETEKMPRKRSGAPVG--------------SSGMAKRGRLQPPSPLGPEGSVEESE---------------------AEASGDEEEGDGTPRRRTGPRR------------------LVGTTNQGDQRILR---SSAPPHLSIPTISHRG-----RKAKT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A087WQ44-1", "uniprot_id": "A0A087WQ44_MOUSE", "id": "A0A087WQ44-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQSSPSTAHPQLPILQTQMVSDGMTGSNPVSPASSSSPDSS---------GAGGISPQHIAQDSSLDG-----------PPGP-----QDGTTVPLEGFSLS--HAADLVNRG----------------------------------------------------------------------------------------------------------------------------------------------QKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPPASSKAGSSPCLGSSSAASSPPPPVSRLDDEDGDFQPQEEEEEDDEETIEVEEQQEGNDAETQRREIELLRHEGELPLEELLRSLPPQLLGGPFSPSQTP-SHDSDTQDGPEENIEEEPSQDLEVHPPSSAVTQCNKQRWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYACDASAPASGDSEDEDEVEANSSDGELEET--VEEAAQEDSSSQSDSAEECSEDEEDEHSEEE-MSGSSQSEESESDESEDAQSQSQADEEQDDEGEDDDVDDDDDDGFGVEYLLARDDERSEVDGGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHR---------EFKEWFSNPLTGMIEGSQEYN-----EGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATEVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPRHRLSHRILLEIATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNSPRPPLGPVPVRPPPGPEVSAQPALGPVPPVLPAPLMVSASPAGTPVVPASRPPGPVLLSPLQPNTGPLPQVLPSPVGVMSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSSLLKPLTVPPGYTLSPVAATTTSSTIATVTTTAVPAPNSTPQRLILSPEMQARLPSGEVVSIGQLASLAQRPVTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALVQAVAPTPGPTPVSVLP-STPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPSSSGLPAVLTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAAPMTISSSLHMPSSLPGPASSPMTIHNSSPLSSP-VSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALA-VVSAASGPP-LASAGVSPSMSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAAS----------QTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVPTLDLSATQTLALAPALTQAPASQASSLVS-ASGAASLPVTMVNRLPVPKDEPETLTLRSGPPSPLPTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKQQRSERLDRIFQLSEAHGALAPVYGTEVLDFCT-LPQPVASPIGPRSPGPSHPIFWTYTEAARR--------------AVLFPQQRLEQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPHQAAFQEQLACELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPPGSSVSSV--------------PEDEEEAVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEANRPGPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPHEEEEGPGAGDEMSCGSSGASHRRSKKIRAPERLGTRVSERLRGARAETQGANHTP---------VTSSHHTCNTFVPPQCSPVRERIPRPV---PRPRPPPPPPAPPPPPAPPASPSPAPPPPPAPASP------APPAPPASPPAASPSPAPLPPAASVASA----ITSALATAPIP-------------------ISAPNPVTILPVHILPTP-PLLQLPPSSSPASTPP----------------------------------------------------------------------------SACTPLPTCTPLQAQTSVLTSSSPAPLDS--LSVPISPGVTN--------------------------LPLDSG-EVGLCAQELAP---------------VESLELPGMTNSEASLAS-------LVSPKDLLPVAVDILPESEKTLPCIP-----APSSTLEAESIPNGQQQEVPGPVEGTNTTLLPGSEELTMSLNESNGLELP----------PSAASAEPLDELLETHRNSGE------TREVQIPISNSEKPQELVRAEVTAPSTSSSATSSPEGPLPARPPRRRTSADVEIRGQGS------------------------GRTGQLPGPKVLRKLPGRLVTVVEEKELVKRRR-HRAPASTLVPG------------------------------VSEVSASPRSPSIHSMSGPESS-----PPSSGPCEAAPTSSLSTPTQSTFIACRHNELG----TTTGGSPENGEGTELAITPPAVKRRRGRPPKKNRSPADAGRGVDEVPS---------SISKGKTNGVDPVPGPE--TVTVAEPDLRPQ--------------------FVPGPQPPGPQPVHR----PEPTILSPVEKRRRGRPPKARDLPIPGTISSPGGGNLESRTQSLPFPAPLT---------------PLLACPTA-VTNTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ--HPVLDPDSSSILESCGLGVQRQPLGQAESEGSSSDEDGS----RPLTRLARLRLEAEGMRGRKSEGSMVMAVIQD----------------------------------------------------------------------------------------------------DLDLADSGPSGLELTPPVVSLTPKFRSTRLRPGSLVPPLETEKMPRKRSGAPVG--------------SSGMAKRGRLQPPSPLGPEGSVEESE---------------------VEASGDEEEGDGTPRRRTGPRR------------------LVGTTNQGDQRILR---SSAPPHLCIPTISHRG-----RKAKT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6ZRS2-1", "uniprot_id": "SRCAP_HUMAN", "id": "Q6ZRS2-1", "name": "Chromatin remodeling protein SRCAP", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQSSPSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASS---------GAGGISPQHIAQDSSLDG-----------PPGP-----PDGATVPLEGFSLS--QAADLANKG----------------------------------------------------------------------------------------------------------------------------------------------PKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETIEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPGS---GSSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQADEE------------EEDDDFGVEYLLARDEEQSEADAGSGPPTPGP-TTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHR---------EFKEWFSNPLTGMIEGSQEYN-----EGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASP-VSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLS--PAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCT-LPQPVASPIGPRSPGPSHPTFWTYTEAAHR--------------AVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSA--------------PEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPG--AEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAETQGANHTP---------VISAHQTRSTTTPPRCSPARERVPRPA---PRPRPTP----------------------------------------ASAPAAIPALVPVP-----------------VSAPVP-------------------ISAPNPITILPVHILPSPPPPSQIPPCSSPACTPP----------------------------------------------------------------------------PACTPPPAHTPPPAQTCLVTPSSPLLLGP--PSVPISASVTN--------------------------LPLGLRPEAELCAQALAS---------------PESLELASVASSETSSLS-------LVPPKDLLPVAVEILPVSEKNLSLTPS----APSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELP----------PSAASDEPLQEPLEADRTSEE------LTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGT------------------------GRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPG------------------------------VSETSASPGSPSVRSMSGPESS-----PPIGGPCEAAPSSSLPTPPQQPFIARRHIELG----VTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPS---------STLKGKTNGADPVPGPE--TLIVADPVLEPQ--------------------LIPGPQPLGPQPVHR----PNP-LLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLP------------PLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ--LPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGS----RPLTRLARLRLEAEGMRGRKSGGSMVVAVIQD----------------------------------------------------------------------------------------------------DLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGG-------------SPGLAKRGRLQPPSPLGPEGSVEESE---------------------AEASGEEEEGDGTPRRRPGPRR------------------LVGTTNQGDQRILR---SSAPPSLAGPAVSHRG-----RKAKT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B358-1", "uniprot_id": "A0A8M2B358_DANRE", "id": "A0A8M2B358-1", "name": "", "aln": "MAEGSSTDHCQDWSQHHGDTGGVSAPFQTAKGPLPPETIKLDYKNVSGKDTSGESPSAPKTEVTPSVKGAVKSTDKDMEHPKPTPLFETNQTAASSVLQKQSTTNSATQLCKFDSKETMEDVTRDLLKTSKEDDISETLSAGGTKQGISGNSICSGYSSKQGGQHITPNRGNNTPNDSDKGSCYLTETCSQTQTSTQKTSTLPKTPGIPTLVENIQCVQELSSQYLHINPKMVTLSKETSTRGDLYCNVAAKEVLCNVSVDEPKLSGHGTCTDTAHVSIMSERSQVMGCGSSDVILKQNDSANQIEISMSSNHQQDGSILLTHAENCVTSEGLESDQPNLSDCLVQQLQESIPTDHKLSQIQICLNNTPDIVNEEERQEMNAEALSAVEVKDLIDVGILMQPDMEDTWLVVSEIDGQPEHGEMEVSDESLVQCPESQSTVAVYECTVPCFTSAAIHSDVKLLLTDKEEEPMETLTQDLQVQSNLGSHPATLKSTKELTIMSSAQKEVAAIVKQNNDSSPTLAKTMTGLTSTLLDVTLDSVHDQQESVVVENTPGVSLISLGTIDPKLLILKKDDRPALKQPSSLSARVATKQNSSILDRSPSNESNKVSECLAKTDTAASSNLKDVKLPADHPVSNTLSQSWTVSTSNVLSQNSSEKEKLYQSSSSGKMLQKESSADTSLSTSVKLHNSESHLTPSPGGVWGPVSDIVPLENQSLDGKPLQDLMSLGGALVLEQQQLPDKLLSTAQDSQHTILEPLDASVEESSDGEADSSLEVQNEDSNAVTNPAENKRGQSRTDRQDLLLKVCQWIAGKVTAASTPSTSPVPCSSPSPSSSDWIRSHTGRTSPIRNSNGKNMPSTSSQGSQSEQTTTPKSTPKHTDLAELAKHEAEIEHRTLALKREGFWSLKRLSRITEPVRPKDHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVMRHHEELRQKEERAKREEQAKLRRVASSIAKEVRAFWSSVEKVVQYKQQSRLEEKRKKALDLQLDFIVGQTERYSDLLSQSLQG---------APVQSSDTAAASKQSQPNPVDEDDRDFEPP-CEEEDDEETIEVEEQQEGNDAETQKREIELLREESTLPLDQLLSTLT--------------------LPQDVESEEEESDTSSLTVE-----------------DEDKEFSANEEDAEDEEETIEAQEVIEGEGDHTEELDDLAREGEMSMEELLEKYRGAYASDFEEPSASADSSE---ESEGTEVEAEEETEGEDSAD-DSGSSSDSQAAVDTEEEDEHEDVQ--------------ESDD----------------------EDDGGEGMEVLLREGDQ-----------SPSVPTSPRPKKEISHIAATAESLQPKGYTLATTKVKTPIPFLLHGTLREYQHIGLDWLVTMNEKKLNGILADEMGLGKTIQTIALLAHLACVKGNWGPHLIIVPTSVMLNWEMELKRWCPGFKILTYYGSQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKSWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHR---------EFKEWFSNPLTGMIEGSQEYN-----EGLVKRLHKVLRPFLLRRIKADVEKQMPKKYEHVVRCRLSKRQRFLYDDFMAQASTRETLASGHFMSVINILMQLRKVCNHPNLFDPRPIQSPFITKDIIYSTASLVQQALETSPFERCDLSMFDLVGLEHRVSRYQADVFLPQRKVTHQLIQEIMESPDPPPRPKPVRMKVNRMLQPLPKTDGR--SAANSPR------PACPPTTTTIQT-----------PKPLITEVTTSQAPSQPATQ------VCPVTPVTALRAPLAPSTIPSAPAVRPPAPQSVTVRPSAPSTITAAPPPQPQ----------PP------------------------QPSSIMTQRVLLSPDMQARLPSGEVVSIAQLASLAGRPVSSSQGSKPVTFQLQGNKLTLSGTPLHQVPVPQPRPIQGNVMHLVSSSGQHHLISQPAQVAVLHTVSQS---VSSSANP-HPASTTPTCSGLAVPFTTAQVATSMVGGPGIVKIVVRQAPSKEGGSIPTLAVPP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPRPAPPQSVTLHPHGSPSPVLRAPTASQLPQRPPVYAAPPR----------------------------------------------------------------------TVASSQTPPARPVLRVLQG---------------------------------------------------------------PPPPPAPEP-----------------------------------------------------------------------PVTKANTPCEDSNEVITLRMSTPKPTSSSQSSSSASHRPRIQPPAPPRSPFYMSWLADTRKAQRDDRISQIMRINELHCTAKPVYGREVLDFLTFLPGPCPSPARPVVNNWSYSGYSSCLIAQSQHTSNILERNTFLREEIHNSEERLRLLSDVIDRFVFVIPPVEARPVTMHSCHPPPSLRHQQAVFSSDLSSYVSPLTHTLHRIQSNMRTYFPDLRLIQYDSGKLQTLHLLLRRLKAEGHRVLIFTQMTRMLDVLEQFLNYHGHIYLRLDGSTRVEQRQALMDRFNADRRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAFFKQQTIRELFDVTEGEKKEAEQSVP--------------QSDDEESINKQKTTILEQALCRAEDEEDIVAASQAKAEQVAELAEFNENIPLDDGDSRDQ-------EEEELSKAEQEIAALVEQLTPIERYAMNFLEASLEDICKEELKQAEEQVEAARKGLDQAKEEGLKLHQSSDSDEEDSVHPSTDEP-TPSRRPRKHKEKGAPSTRVSGRLRGTPADDISLTQTSPDRGRRTAWLNSERSISQTPGSTQKSPLNREVPEKLRSGPRGRCTTKESASLENQTIPTNQQLIDSTTLSPAMRDSYPKISVPSPHQQSISPSSSVPSAAASPSLDRNSCGHLSSSTVACREDSEDQKGEARSENVQSRDRRASASSDSICSPEHHSEQEGQLSLSPTLASPNSRSPRKRQSAEWEILKGLPEDSPSAKVLRKLPGRLVTVVEEKEPKRRRRGVSGSGGLHEGSSEEPEKTEPVQDTVPHSSDGSTQTFKVSPPKSVLTSLHSSPPPTPREQEQTSSPLPYSCTGRGHNPCSPTHHSPDMPVLRNLPVRRRLETESRLAAQLGEQFLGRGRGVDRKSASTQKRIETSTDKDGSTPCDSSLMSRRKRGRPPKTPPRALELSEENTPVIEKTSPERS-----PPHSPKRKRGRPRKDSTTTTGSPPSSPSAGAPSSQEPNLSRSNVMPETLPTDSKISPISSPTLCPTSPLNAAEVSSPPKPDSEIIQTTTSVLLSTSPSETGVDSHVDTYASPNTISSCNDSDNSTLVSLSHSTSTAAPYETCTDSSPTLQFTYSFREPPVTTVSICAEEIAHTSVLSDASEITAYSESLTVSTAAVEAEENSVTDNQQVNNLQPSNTSTQVTSQCEDETDPTTDLPQTTLEPIYSVAESSTPTDQPSIQPSSPPALTSEIEPEASSSILEAPETSAVQTVSTVQRSLPQSEQISPPSQLQTTAMEAVSDSPSQQISSSSLQSLSATNPVTTDSLSTLSTDADSSQSQNIVVETMIDNHEGPHSPKEKVETEEEEVLTEEEVVTEEEE-----------QEVVTETEVVTETEKMETDSVGEDDAGEKDDILSQPKKRRLECLPKDQTPSASGVASSDIESHDVQKSDGPDKPLEEEEPEDK---------EPRSSIRTRSISRQSSQETVRSSSPSSVSSCGTRSSRSKKAAENKNPVKRKRSEIKSEKKKSKEGSDKKHQSNSSSSSSDSEDSNSVKRCLTRSAQKKLEKEGMIAKNDESSTRQKARSDKKAKSTNSTEGESSGEVCSRVTRKSTGPQPNTLASPEPEVLGKRCSALNAAAKLLAMRARGPDTPSSSPKNKTAAHQSKTLTSEKVSKPKVNPGQDSPKVSNNKAESGKQPLGQSTESPQSSSSARSTRQRPGSLVPPLEVERVKKEEKKKPSDQKEEGEDEIRETRSSRGHSACSSISSERGVGSSRSRSSSNSSQRTHSLSSQSTDPIRTRSRATSSGSDTERSKSIQRKNDGGRGRESRKENKSQKLDKAELSAGSGDGTPDRVLRSVAALAAAHALTPACNTRSSTSQKRHSKT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q05471-1", "uniprot_id": "SWR1_YEAST", "id": "Q05471-1", "name": "Chromatin remodeling protein SWR1", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTSRKSHAKDKKAGGEQDLADLKFRYDLLTNELFHLREFVSLVDYDPTHFNDSESFQKFLRETHLSLEER---GEKFTDDVAKKGTNGDLTRRRRNLRTSTVVSSETTNE-----------------KKGDIELKLESIA-------------------------PLVRNKCEELKYKLSDHSNRKSIVPQKRPIQHLKKREAAKSLKFKSERKE-----------------NPLPLHEHIAEERYDHIAKVEEPSEAFTIKCPSDDSSFENTSEHYSDNFYFTTSSEEEDIKKKRGRKKKKPRIKLVVH---PPKQTITNPLHVVKPGYESLHEYIASFKS-LEDDLTLEEYNKYIDEQRRLLSRLKKG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IENGALKYDKETDSLQPITSKEIKTIITYKPDPISYFYKQQDLQIHTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAGAEERKAKEEERHKKSLARFAVQAVKKRWNMAEKAYRILRKDEEEQLKRIEGKQHLSKMLEKSTQLLEAQLN----------------------------------QVNDDGRSSTPSSDSNDVLSESDD-----DMDDELSTSSDEDEEVDADVG-----------------------------------LENSPASTEATPTD--------------ESLNLIQLKEKYGHFNGSSTVYDSRNKDEKFPTLDKHESSSSESSVMTGEESSIYSSSENESQNENDRESDDKTPSVGLSALFGKGEESDGDLDLDDSEDFTVNSSSVEGEELEKDQ------------------------------------------------VDNSAATFER-----------------AGDFVHTQNENRDDIKDVEEDAETKVQEEQLSVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVIDGKKVSGFADLDAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPNLFEVRPILTSFVLEHCVASDYKDVERTLLKLFKKNNQVNRVDLDFLNLVFTLNDKDLTSYHAEEISKLTCVKN----------------------------------------------------------------------FVEEVN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------KLRETNKQLQEEFGEASFLNFQDANQYFKYSNKQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLEGTVDMLNFLKMVNKLRCDRRPIFGKNLIDLLTKDRRVK--------------------YDKSSIIDN---------ELIKPLQTRVLDNRKIIDTFAVLTPSAVSLDMRKLALGLNDDSSVGENTRLKVMQNCFEVSN-PLHQLQTKLTIAFPDKSLLQYDCGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERFNTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQEGDFTTDYFSKLSVRDLLGSELPENASGGDK----------------PLIADADVAAKDPRQLERLLAQAEDEDDVKAANLAMREVEIDNDDFDESTEKKAANEEEEN-----HAELDEYEGTAHVDEYMIRFIANGYYY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9NDJ2-1", "uniprot_id": "DOM_DROME", "id": "Q9NDJ2-1", "name": "Chromatin remodeling protein domino", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEGNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHHQHIATQVKGIASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSSTIEASVLPPQAK---RQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSSTALQDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEAEIKIPAVGATPVAISTKLPAAVVQLTQQGGTPLLPCNTS-AGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALGGSGGLTPGTPTSGSLLSPALG-----------------------------------------------------------------------------------------------------------------------------------------GGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNK------------SVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEE-----DAADVKEEVTALAKESEMDFDDFLNDLPP------------------GYLENRDKLMKEEQSSAIKTETP--------------DDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKS-------------------------------------LMADADATSGAAGSGS-----------------TAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHR---------EFKEWFSNPMTGMIEGNMEYN-----ETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPR-----LVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRK----------------------------------------------------------------------LIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMR------------------------------------------------------------NLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLN---------HLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEG-----GPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYS------LSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVN----------------LQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWR----------------------------------------------------------------------YETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTATNIITTTGPQQQQQGVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKG-----------------------------------------------------------------------------LSNSVTMQQIQQVMRSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGNLLAVVQQQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQPTTQQVRKLVQKKILIRSEKE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : . : . . . . . . : : : :: :. :. . : : * *:* :: :: * .. : : *:* :*: ::.:. :* : :: : : :* .: *: *. .** . :: . *: :: . :*. :: :: : : : : : * .. ..:.:: : :: * .* . ::. .. . : : : ..*: .. : : : .. :..: : * . . . .. . : :. : .: . :::: . .. . *. :.* : * .*:* **: ** **: **:**.:: :.: *****************:***:*** * *******:**:**:******:*::.*.**:*****: ::** ** **.**:******.**:**:**:::*:** *:*::****:*****:* *** ****.::************.* *****::**** .. . : *::**..*: :** . ::. : : :**:*:**:****:* :****** ****:: *:**:*** **:***::: *: ** :*:::*::* ************:*: ** :.* : . .:* *: . : . : :: . : .. . .. : : :. : :.. : *::* : : : : * :: * . *.. : : . : . ** : :: *** *:***.****.: **::** :***.*******::***** **.***::*:****:*::*:** * :*** * ** ****:****:*:********:********:** *.*****************::**:*:* ********** *.::.*: *:*** :*.. ::::*: * . :. :*: *. ****:*: *:. * * : :*:*. : . : : .. .: : :: . * ", "identical_positions": 349, "similar_positions": 334, "identity": "7.61%" }, { "cls_id": "homologset.agr.HGNC:16976", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7Z465-1", "uniprot_id": "BNIPL_HUMAN", "id": "Q7Z465-1", "name": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein", "aln": "------------------------------------------------------------------------------MGTIQEAGKKTDVGVREIAEAPELGAALRHGELELKEEWQDEEFPR-------------LLPEEAGTSEDPEDPKGDSQAAAGTPSTLALCGQRPMRKRLSAPELRLS----LTKGPGNDGASP------------TQSAPSSPDGSSDLEI--DELETPS----------------DSEQL---DSGHEFEWEDELPRA--EGLGTSETAERLGRG-CMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDG-LNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99JU7-1", "uniprot_id": "BNIPL_MOUSE", "id": "Q99JU7-1", "name": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein", "aln": "---------------------------------------------------------------------------------------------------------MKLGELELREEWQDEEFPR-------------LLPEEPGSPGDPEDPQRGSQ--AGTPSSLALCGQRPMRKRLSAPEWQLS----LTEGTGENGASP------------TRSASSSSAGSLDLEV--DELETPS----------------DSEQL---DSGHEFEWEDDLPRA--EGLGASEAAERLGRG-CVCDVAGEDGHRWRVFRTGQREQRVDMTIIEPYKKVLSHGGYHGDG-LNAVILFASCYLPRSSIPNYTYIMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALVRPFISSKFTRKIRFLDSLGELAQLISLEQVHIPEVVRQLDRDLHGSKGT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A8DZD4-1", "uniprot_id": "A8DZD4_DANRE", "id": "A8DZD4-1", "name": "", "aln": "------------------------------------------------------------------------------MGTYSDQRE----AYMQNGHTENSRTSDFIPDMELREEWQDEEFPR-------------PLPEDTHSPGDEEESAGAEGKKPVPPTSLALTGNTVRKKRLVAPTLSLT----LDKTSTDRSLKSDEFE--------ASALSPSPDDDLDMDINLEALETPS----------------DSESYNFPESMHDLEWEDDLPRMGKASIRKPSLLEHAEMGHLELDQVDDYGRRWRHFHIGGQDYQVNMSVLEPYLQVLSHGGYYGDG-STAIIMFTSCYLPENTTEHYEYVMDNLFRYIIGTLDLMVSENYILVYLCGMAPRNKMPGIKWLRQCYMSIDRRLRKDLKGLFVVHPAWYVRALITVIKPFISEKFSRKMRFIHSLQELAEFVPVEQLQIPDCIREYDTQLNR----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VZJ4-1", "uniprot_id": "Q9VZJ4_DROME", "id": "Q9VZJ4-1", "name": "CRAL-TRIO domain-containing protein", "aln": "MSLHYAESESSPSESKMDISETPTDSTGVSPLADDVLPTAPEKNILKLEQAKQDHDKEELEFKTTSALDNRILRPELLPMEAMPQRHNIIERTLANSHPLMSPTNTDSDSEPFQLKKQEKQLPRSNFPDVVPTTETVQVKNNLNQCRNKPQDAKVSLLRANSPDILSSESDADVSQYLAAVESNFQSVSLMPNGNGKKSKRSTALPGGEDISSLDSISNHSFDDDEDIEHNLASLSPSSSLIDGLDGEDDDDDCEGPELLPDHDDDLELDLEFGLATTPTPNAPASATAASTLPQYTAAEERRDSRNWQKITLPDGRTREIDMRVIEPYKRVLSHGGYLKSGGQNAIVIFCACHLPDRSRADYSYVMDNLFLYVVKTLEQLVTDDYVLIYLHGGSNRRNVPPFPWLKRCYQLLDRRLRKSLKHMYLVHPTFWIKSLVWMARPFVSTKFWRKLVYVKSLEELGMHVVVEKAAIPEKVKQYDAKRH-----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: : *::::** : :: : : . . .* *: .: : * * : : : . . . * .. *:: *...* ..* :. ::: * *. . . : : . : . : .::* ::*** :******* .* .*:::* :*:** : .* *:*::** *:: **: :*:::*:*::* * : * ::* : *:::** :******.*: : :**.:::::::: : :**:* ** **: ::.** **. : ::: **: ::: * . : ", "identical_positions": 72, "similar_positions": 116, "identity": "14.72%" }, { "cls_id": "homologset.agr.HGNC:16977", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QUJ0-1", "uniprot_id": "HCST_MOUSE", "id": "Q9QUJ0-1", "name": "Hematopoietic cell signal transducer", "aln": "MDPPGYLLFLLLLPVAASQTS--------------AGSCSGCGTLSLPLLAGLVAADAVMSLLIVGVVFVCMRPHGRPAQEDGRVYINMPGRG--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6X9T8-1", "uniprot_id": "HCST_RAT", "id": "Q6X9T8-1", "name": "Hematopoietic cell signal transducer", "aln": "MAPPGHLLFLFLLPVAASQTN--------------EGSCSGCGPLSLPLLAGLVAADAVMSLLIVGVVFVCMRLHSRPAQEDGRVYINMPGRG--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UBK5-1", "uniprot_id": "HCST_HUMAN", "id": "Q9UBK5-1", "name": "Hematopoietic cell signal transducer", "aln": "MIHLGHILFLLLLPVAAAQTTPGERSSLPAFYPGTSGSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQEDGKVYINMPGRG--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QIP7-1", "uniprot_id": "F1QIP7_DANRE", "id": "F1QIP7-1", "name": "Hematopoietic cell signal transducer", "aln": "MTKKGLLVFLLSLIVMVRAD----------------GDKYSCFGVSSGTVAGIIFADVAVTVLIVTTTYWYASKRRQKKENADEVYMNVRANCKT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * ::**: * * . *. .* :* :**:: **.. ::*** ..: : :: ..**:*: .. ", "identical_positions": 19, "similar_positions": 26, "identity": "20.0%" }, { "cls_id": "homologset.agr.HGNC:16978", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LL42-1", "uniprot_id": "A0ABK0LL42_RAT", "id": "A0ABK0LL42-1", "name": "", "aln": "MRRYRTGSHTKMFLTPPSTPPPLQAQSSAPYIVILFSTAVDSLGAPKGRRLCFSDLRTSVPAAIRDVGTGWVALVPAMMSSLKAWDTLLLLLCLQYSLPAQST--SRRQFMEQHHLSSNEEFSAYSCDVLMTEK-ALRPRLSHPFVYMTWYKVEHICISSNWKDRYKNLYVWAQTPIKVLRCQWENLKSRYTERRSYSYVQFHCNADGYVDSIEDMKVLEPIFI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14507-1", "uniprot_id": "EP3A_HUMAN", "id": "Q14507-1", "name": "Epididymal secretory protein E3-alpha", "aln": "-----------------------------------------------------------------------------MTSSLKIWGILLALLCILCRLCVYSNNIYWREFIKLHYLSPSREFKEYKCDVLMREKEALKGKSFHMFIYSLWFKIQRACINEKGSDRYRNAYVWAPGALKVLECHWEKYNNRYTESRSFSYIEFHCGVDGYVDNIEDLRIIEPISN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * **** *. ** ***: * . *. *:*:: *:**...**. *.***** ** **: : * *:* *:*::: **..: .***:* **** .:***.*:**: :.**** **:**::***..*****.***::::*** ", "identical_positions": 73, "similar_positions": 42, "identity": "32.59%" }, { "cls_id": "homologset.agr.HGNC:16979", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ATZ0-1", "uniprot_id": "A0A8I6ATZ0_RAT", "id": "A0A8I6ATZ0-1", "name": "", "aln": "MRFCILLLFASIFLTSWLSTAKGEVEVKCLAPHIPNG--NYTPHRINYT---AEDEIQYECTDGFYPTTQG--TVAKCTSTGWIPAPRCSLEPCDFPQFKNGYLYHENIRRSYFPVPIGKEFSYYCDNGFLTPSGSYWDYLRCTRQGWEPEVPCLKTCLKSDIEIENGFLSQSDSKYLQNKKAQYMCKQGYVTADGETSGSITCLENGWSAQPSCLKSCDVPVFENSVTKNNSTWFKLNDKLDYECHIGYKNKYKHTKSSITCTYEGWSDEP----------------------------------------------------------TCYDSTKICGPPPPIENGDITSFPLPVYIPPSSVDYQCQYLYQMQGNKTIICINGDWSEPPKCLRMACKPPDIPNGIYSPQRVTYTAQDEIKFECKDGFYSATQETVAKCTSTGWIPAPKCMKPCEFPQIKNGGLYHERRRRPYFPVPIGNEYSYYCDNGFLTPSLSYWDYLRCTEKGWEPEVPCLKQCVFH-----YVENGESSYWQRKYVEEQAVKVQCYNGYSLPNGQD--TITCTENG-WSP-PAKCIKSCDVP--------------IFENAGTNNDSTWFKLNDKINYECHVGYVNKHKHTKGSITCHHDGWSDIPSCYDSTKICGPPPPIANGDTTSFPLPVYIPPSSVEYQCQSLYQLQG----NKTIICINGEWSDPPKCLHPCIISIEIMRKHNITFRTEENQRLYYQSGEMQEFKCKNGHHLAT-TQPLITICINGHLNYPVCTK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A668KLU9-1", "uniprot_id": "A0A668KLU9_MOUSE", "id": "A0A668KLU9-1", "name": "", "aln": "MGFCSMLLLSNILLTAWLSTAKGE-EKTCSPPYVPNI--IYTPHRIIHR---TADEIRYECKNGFYPATRS--AVSKCTLTGWIPVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YS-----------------------------------------------------------------------------------------WDYLRCTAQGWEPEVPCVRKCVFH-----YVENGDSTYWEKIYVQGQSLKVQCYNGYSLQNGQD--TMTCTENG-WSP-PPKCIR-----------------------------------------------------------------------INSTRTCGPPPPIDNGDITSLSLPEYEPLSSVDYQCQKYYLLKG----NKTITCRNGNWSEPPMCLHACVIPENIMEAHNIILKWRHTEKIYAHSGEDIEFECKRGYQKARGSLPFRTKCINGTINYPTCV-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92496-1", "uniprot_id": "FHR4_HUMAN", "id": "Q92496-1", "name": "Complement factor H-related protein 4", "aln": "-----MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPC-LRTCSKSDVEIENGFISESSSIYI---LNEETQYNCKPGYATAEGN-------------------------------------------------------------SSGSITCLQNGWSTQPICIKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYESSYGNTTDSIVCGEDGWSHLP----------------------------------------------------------TCYNSSENCGPPPPISNGDTTSFPQKVYLPWSRVEYQCQSYYELQGSKYVTCSNGDWSEPPRCIS--------------------------------------------------------MKPCEFPEIQHGHLYYENTRRPYFPVATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDI---EIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNG-WSA-QPICIKFCDMP--------------VFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQG----SNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0G2K975-1", "uniprot_id": "A0A0G2K975_RAT", "id": "A0A0G2K975-1", "name": "", "aln": "MRFYSIWLLANILLITSLSTAKGE-VKKCNFSQIKNGHLYKGDIYRFYLAISTEKEFRYYCNSGFVTPSGSHSDYLRCTIQGWEPAVPC-LKECVLHYVENGYSLFLERKFVQD-----QSVKVNCYKGFNLPNGQDTITCTESGWTPQPICIPSETCSKSDIEIDNGFFSESDLTYAVNRKTRYVCKQGYTTANGERSGSITCLQTGWSAQPSCIKSCDVPVFENAKSKNDSTWFKLNDKLDYECHIGYENKYKHTKGSIMCTTDGWSDKPSCYEIECSIPILDPRLVVYPRKIKYTVGDLLKFSCRPGHRVGPDSVQCYDFGWSPSFPTCKGQVRSCGQYPELLNGEIKGTKKAEYSHGDVVEYDCKPRFLLKGPNKIQCVDGKWTTLPTCVEEKRTCGDIPALEHGSVKFSVPPYHHG---DSVEFTCAETFTMIGQRSVSCISGRWAQLPRCVATVQLEKCKAPRLAVIGANKLEKDGLNHNSSISYKCRGSQKYGYSICINGRWDPEPTCTRKEKAFCPPPPQIPNAQVIDTTVKYLDGEKVSVLCQDGYLTQGPEE---MVCKHGR-WQS-LPRCTAKITCSQPPKIDHGSIKLPRLSDAGRDAIDSSSHEHGTTFSYVCDDGFRISKEN---GVTCHMGKWSSPPRCVESTGKCGPPPTIENGDITSLSLPVYAPLSSVEYQCQSFYKMQG----SKKITCKNGEWEEPPKCLHACVLTEEIMRRQNIIPKRTKNKKIYIQSGDYVEFVCLTAYQKAQGSPEFRTQCIDGHINYPTCSK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0AB13A945-1", "uniprot_id": "A0AB13A945_DANRE", "id": "A0AB13A945-1", "name": "", "aln": "---MKNFKIFLFLLLTIMDVPTNAEEVTCDEHQLINVYILMGHPGVSAP-YKPGHILVFRCTDGNMMMYGHRSIECLSNGKWDNPYPKCGVAMCPIN-TPVQNLKFERFPDIEGPIKPGHWMTFSCTEPWMKLKGQ---------------------------------------------------------------NEITCLVNG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EWSSAFPRCEETTCAANLTVNMRSDVE----------GQPGREISVKPGHTVTLSCVRGAQFQGQNK---ITCRSNGEWDAPFPKCVG---------------------------------------------------------------------------GICGPPPNVDNADTIYMQKTEYSSGERVEYRCFDKYTMDDRPSYSSYMTCQDAEWTGKIYCLKPCSVTLDTMNEKGIKVKYGPPRKLFSPHKDQILFACLRENERMKGNSKQ--ICNDGTMTLPECV-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .:* :. ... * : : . . : * .. .. * * : * . . * : .* : * . . . : * * . :. :.* . *.. . * ***** : *.* : * . . *:*:* . * :.. .. : * :.:* *::.* :. : *. :.* : : : : * * . * :* : * * ", "identical_positions": 38, "similar_positions": 69, "identity": "4.83%" }, { "cls_id": "homologset.agr.HGNC:1698", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1MAC3-1", "uniprot_id": "F1MAC3_RAT", "id": "F1MAC3-1", "name": "", "aln": "MLGGLGVLRTLPL---LLLFLSEACLGPGCQALMLERDPPSLTVNLGEEAVLTCKNDG-KNPNITWWF--------SLQSNSTWPPMPLGPGLGPMG-----KLIFPEVNKSHRGLYWCQVIESKE-VKRSCGTYLRVRKQVPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKFGVDMPDDYEDENLYEGLNLDDC-SMYEDISRGLQGTYQDVGSLHIGDVQLEKP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P11911-1", "uniprot_id": "CD79A_MOUSE", "id": "P11911-1", "name": "B-cell antigen receptor complex-associated protein alpha chain", "aln": "MPGGLEALRALP----LLLFLSYACLGPGCQALRVEGGPPSLTVNLGEEARLTCENNG-RNPNITWWF--------SLQSNITWPPVPLGPGQGTTG-----QLFFPEVNKNHRGLYWCQVIENNI-LKRSCGTYLRVRNPVPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKFGVDMPDDYEDENLYEGLNLDDC-SMYEDISRGLQGTYQDVGNLHIGDAQLEKP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P11912-1", "uniprot_id": "CD79A_HUMAN", "id": "P11912-1", "name": "B-cell antigen receptor complex-associated protein alpha chain", "aln": "MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWR--------VLHGNYTWPPEFLGPGEDPNG-----TLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDC-SMYEDISRGLQGTYQDVGSLNIGDVQLEKP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1P8N4-1", "uniprot_id": "A0A8M1P8N4_DANRE", "id": "A0A8M1P8N4-1", "name": "", "aln": "----------MGFRLVLFLSFFAAVLSGKLEDLQLEPDEPLLRVQVSQEATVRCCYRCKESPEVSWIKNTPAINGTTMPDLVNFTKNVMNKPEGEKDGVICHSLVFKSVSVNDMGLYQCKLKHGLL-TFFSHGTFLQIYLPLEK-TLNLSEGVKNSIITVEGVLLLMCVLIPGTMLLCKSKKVN---KLDRKTEREEENIYEGLNLDDCNSAYHQIQRSIQQGPYEDVACCEEDIQLEKP", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *:: : . *. : * :. . * *.:.::* . * ...:::* : . .:. :. . . *.: .*. .. *:* *:: .. * **:*:: : *::.**.** ***.**::**:*.::***:** :.: * :* : *:**:********* * *.:*.*.:* : * *****", "identical_positions": 60, "similar_positions": 71, "identity": "25.0%" }, { "cls_id": "homologset.agr.HGNC:16980", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A668KLU9-1", "uniprot_id": "A0A668KLU9_MOUSE", "id": "A0A668KLU9-1", "name": "", "aln": "MGFCSMLLLSNILLTAWLSTAKGEEKTCSPPYVPN--IIYTPHR---IIHRTADEIRYECKNGFYPATRS--AVSKCTLTG-WI-PVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSGYSWDYLRCTAQGWEPEVPCVRKCVFHY----VENGDSTY-WEKIYVQ-GQSLKVQCYNGYSLQNGQD--TMTCTENGWSPPPKCIRINSTRTCGPPPPIDNGDITSLSLPEYEPLSSVDYQCQKYYLLKG----NKTITCRNGNWSEPPMCLHACVIPENIMEAHNIILKWRHTEKIYAHSGEDIEFECKRGYQKARGSLPFRTKCINGTINYPTCV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q02985-1", "uniprot_id": "FHR3_HUMAN", "id": "Q02985-1", "name": "Complement factor H-related protein 3", "aln": "-----MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNG-WS-PAVPC-LRKCYFPYLENG---YNQNYGRKFVQ--GNSTEVACHPGYGLPK--AQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISE-SSSIYIL-NKEIQYKCKPGYATADGNSSGSITCLQNGWSAQP--ICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQG----SNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRCE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A945-1", "uniprot_id": "A0AB13A945_DANRE", "id": "A0AB13A945-1", "name": "", "aln": "--MKNFKIFLFLLLTIMDVPTNAEEVTCDEHQLINVYILMGHPG-VSAPYKPGHILVFRCTDGNMMMYGH--RSIECLSNGKWDNPYPKCGVAMCPINTPVQN-LKFERFPDIEGPIKPGHWMTFSCTEPWMKLKGQNEITCLVNGEWSSAFPRCEETTCAANLTVNMRSDVEGQPGREISVKPGHTVTLSCVRGAQFQGQNK---ITCRSNGEWDAPFPKCVGG--ICGPPPNVDNADTIYMQKTEYSSGERVEYRCFDKYTMDDRPSYSSYMTCQDAEWTGKIYCLKPCSVTLDTMNEKGIKVKYGPPRKLFSPHKDQILFACLRENERMKGNS--KQICNDGTMTLPECV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: ::** ::.: .*. : : :: .. : * : .* .* * * * : * : . ::. : *: * : . . : .. * . :... .* : .: : .* * . :. :** .** * :.. ***** :.*.* : * . . *:*:* * :.. .. :** :.:*: *::.* :. : *: :.* :* .* :: : * * * : . : * :* : * * ", "identical_positions": 49, "similar_positions": 91, "identity": "13.88%" }, { "cls_id": "homologset.agr.HGNC:16982", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZRZ8-1", "uniprot_id": "A0A8I5ZRZ8_RAT", "id": "A0A8I5ZRZ8-1", "name": "", "aln": "MAGKDSGNLKTVRLWRDAALRARKLRSNLRQLTLS----CPGAGGDSLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPL-QLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPTPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWING-TNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3V1N1-1", "uniprot_id": "MFHA1_MOUSE", "id": "Q3V1N1-1", "name": "Malignant fibrous histiocytoma-amplified sequence 1 homolog", "aln": "MAGQDSGNLKTVRLWRDAALRARKLRSNLRQLTLS----CPGAGGDPLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKNDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPL-QLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPSPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWING-TNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y4C4-1", "uniprot_id": "MFHA1_HUMAN", "id": "Q9Y4C4-1", "name": "Malignant fibrous histiocytoma-amplified sequence 1", "aln": "MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPR-HLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELLRATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSTAWYKFPCYVQNEVPHAEAWING-TNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6D2-1", "uniprot_id": "A0ACD6B6D2_DANRE", "id": "A0ACD6B6D2-1", "name": "", "aln": "MAEET--NLKTARLWRDAALRSRKLRSNLRQLTLS--------------TKNSQKITLPEDIKEIEVLNLGNNSLQELPEGLGSTLTKLRILILRRNKFATVPSAVFQLS-QLVELDISHNCLNHF-SEDIDLLKGLKKLCFSHNKIQYLPSQIGTLQSLEELDISFNELHDFPRSFSQLRKLRTLDVDHNKLQRFPSEILALSDLEELDCSGNKLEGLPGNIMMLQSIKILWLSSTHLLSLPETFCELQNLESLMLDNNFLTRLPQSFGKLQKLKMLNLSSNSFEDFPQVIIKLTKLEELYLSRNKLTFLPEEVGQLCNLANLWLDNNSITFLPDSIVELGKLEELVLQGNQIAILPDNFGKLAKVNIWKVKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAIKPRLKLVLMGQGNAGKTTLRQCIVSKQSD-------------TKMAIGCRGIDVTNWVADAERSLTFIVYDLSGKQNYDLIKPFFLSPGALYVLVVNLKLYTSKSFYSHVGSFLHLLSAKVPHAVVCIVGTHSDLCEEVEVEEKCLDIHRQISFQEKMDIDCLHVLALQVDEALEQGYDVRTSTPHVLFYGVTDKNLRRKKSQLQYMLNNRLQILSPVICVSCVAAQRNIQHLKEKLMSVADHREIFPNLHRVLPKSWQMLEELHFKP---QDLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSTTLKEYVFHNLPRFIAILNVFFQRDLPAMLEKLQA----EGD-DGDN----AVS---------TQMHSHVEGFLSHGLLPSNVIRLLLKPLVQTQQDLHLIMELLEKMGVCYCVNKPRCKPLNGATVWYKFPSQDINEEPKPEASGSGGLSIPGQFFSVEQLQIEYRFPFFTPLGLFARFSVQINSHVVQRSDGKHHIFAYRGKVPVTVSYRSSRSRFQPEILSISSHASLPNIWTAWQAIIPLVEELNVLLQEWPGLHYSVHVLCSKCLKRGSPYPHSFPGELLSQPRPEGLTEIICPKNGSERVNVALVYPPTPTVISPSHK----------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ****.*********:************: : : ::.** :: :**.******.*:::******:* .**:*:****:** :*.** :*. :*.***:*** *. : :* :. *: *:** :***:: **:*:*:* *****:***.* .:* *:* * :*********:* ** ::* * ***** *.*:*.*** :* *:::******.:.* :** **** .********* * ** .*. **:********* **:** .:: *: *********:** :*. :. * .* .****** * :******** ************:***:**:*::*.:**:*********************************::*****:***: **** **:*:...: : . . .:**:**.*.***.*.* ******:*.:.*::*:**************** * .: * : ****** :.*:************:*** * *:***********::*** * : * ** ***** :.:::*:::**. :***:******:*:::**:**:********: *** . ::::*::**:***:*************:***:******:* * *****************************************.:***:*****.*:* ********* . :*.** **. :*:. * . **:* :***** *****:::******* **:****:*::*******:***:***: *****::.*****. ** *:.** .* .:.** * .******* *** * *****:*********:*****.:**********.****.::. :**: ***:*************** ******************:**:*********** **:*************::***************************. * ", "identical_positions": 665, "similar_positions": 208, "identity": "63.09%" }, { "cls_id": "homologset.agr.HGNC:16983", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WUQ3-1", "uniprot_id": "OLIG1_RAT", "id": "Q9WUQ3-1", "name": "Oligodendrocyte transcription factor 1", "aln": "MYYAVSQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSST-------SSSSTASLLPKPAREKPEAPLAEPRGPAPES-----GGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHC------------QGAP--GRKLSKIATLLLARNYILLLGSSLQELRRALGD-----GAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFALPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JKN5-1", "uniprot_id": "OLIG1_MOUSE", "id": "Q9JKN5-1", "name": "Oligodendrocyte transcription factor 1", "aln": "MYYAISQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSS--------SSSSTASLLPKPAREKAEAPLAEPRGPAPES-----GGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHC------------QGAP--GRKLSKIATLLLARNYILLLGSSLQELRRALGD-----GAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFSLPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TAK6-1", "uniprot_id": "OLIG1_HUMAN", "id": "Q8TAK6-1", "name": "Oligodendrocyte transcription factor 1", "aln": "MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAP-AEPPGPGPGSGAHPGGSARPDAKEEQQQQ-LRRKINSRERKRMQDLNLAMDALREVILPYSAAHC------------QGAP--GRKLSKIATLLLARNYILLLGSSLQELRRALGE-----GAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8WIQ7-1", "uniprot_id": "A8WIQ7_DANRE", "id": "A8WIQ7-1", "name": "", "aln": "---------MQAVSGVRYREQ-------GESSLQQLMPRMVRVTGSGG---------PGSNVGSLQGPLRS------SKPP--------------RELSSEE--QQELRRKINSRERKRMQDLNVAMDALREVMVPYSSSPTGVGGALQHPYLPPGAPTTGRRLSKISTLVLARNYILLLGSSLQEMRRLLGEVSIGMGVSGTVPRLLLTGGWPFLTGPGQLLLSP----PEQQLGVAKCPLLPQGAQEE-PLAWGPGSMSESPVCQCGVCRTPRVVHVNP-----AMRFPK", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::*.... * * * * : : * :.*.. ..:.. * . *. ::* * :.** ** *****************:********::***:: *** **:****:**:***************:** **: *.. :.*****:* : :.**.:**:* * : * :* *. . :: *. . . :* *.**: *::* .. :*.*", "identical_positions": 98, "similar_positions": 62, "identity": "33.56%" }, { "cls_id": "homologset.agr.HGNC:16984", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LRZ9-1", "uniprot_id": "F1LRZ9_RAT", "id": "F1LRZ9-1", "name": "RUN domain-containing protein 3A", "aln": "MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLPDPPPPPRTGLIPGDHAPLAQGSKELTTALVNQWPSLSTLSRPEGASNSKLFRRHSFMSTEPLSAEASLSSDSQRLGEGKRDEEPWGPIG--------------SSEPN---------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O08576-1", "uniprot_id": "RUN3A_MOUSE", "id": "O08576-1", "name": "RUN domain-containing protein 3A", "aln": "MEASFVQTTMALGLPSKKASSRNVIVERRNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPASWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDNRTTRRFYDSGAIMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYNKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQL--------TGLIPGDHAPLAQGSKELTTSLVNQWPSLSTLHRPEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEAKRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q59EK9-1", "uniprot_id": "RUN3A_HUMAN", "id": "Q59EK9-1", "name": "RUN domain-containing protein 3A", "aln": "MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQL--------TGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A7YDW0-1", "uniprot_id": "RUN3A_DANRE", "id": "A7YDW0-1", "name": "RUN domain-containing protein 3A", "aln": "MEQSFMQSAMAMGAQSKKGFSRSIAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFINFAAILEHILSHRFK-----GSGSWF--DGQRSFWDFIRLACSKVPNNCISSIENMENINSSRAKGRAWLRVALMEKRLSEYIATALRDSRTTRRFYDEGAIMLREEATVLTGMLIGLGAIDFSFCLKGEALDGKSEAVIDYTPYLKFTQSYDYLSDDEDGQSVDSSNSDDSV-EHPYIPLVTDEESWRNKCRKMEQRFKIVNAQKGYLEELVRLRESQLKNVEMENKKLTAGLEELQQQSQKEKRELENIILELQEQL--------TSLIPGESHPLS---KDLSIPLVNQWPSLQNYNNQE---DSKLYHRGSFPSPEP---HISLTTGSQRT-ERKQNGKSWCTAEKDYTPSMLGLCGSMSSLPSCKSLPSLRSTECLVNISAEPSPALTPS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1QCE8-1", "uniprot_id": "F1QCE8_DANRE", "id": "F1QCE8-1", "name": "RUN domain-containing protein 3A", "aln": "---------MAMGLTSKKTSSRNIGVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFINFAAILEHILSHRFK-----GPGGWFSSDGQRSFWDYIRLACSKVYNNCISSIESIENISTSRAKGRAWIRVALMEKRLSEYVAIALRDTRTTRRFYDDGAVMLREEATVLTGMLIGLSAIDFSFCLKGEVLDGKTPAVIDYTPYLKFTQSYDYLSDEEDRRSVDSSASDESVAEHPYIPLVTDEETWSNKCRKMEQRFKIVNAQKGYLEELVRLRESQLKNVETENKRLDAKLEELQVQSQQEKKELEAIILELQAQI--------TGIIPCEPSHLV---KGLSIPLINQWATAQATNNQG---NVKLFRRRSFHSLDLS-ADLSLNSDSQKE-DGNQNGDTVWSAAKDNTPSMLGLCGSLASLPSCKSLASLKSSEYLVNISTEPSPALSPS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **:* *** **.: ***:*****************************:*******:******* *. .** ****.***:******** ***:****.:***.::*******:********:***:: ****.********.**:***:***:********.***********.****: .*****************:*:*: :*.:** *::. ****:******::* .* :****:*:** ******************::* **::* *** *.*:**:*** :***** *: *.:** : * * *: .*:***.: : **::* ** * : . **.:.**: : .:: .. . :* *. ", "identical_positions": 245, "similar_positions": 80, "identity": "53.96%" }, { "cls_id": "homologset.agr.HGNC:16985", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VID1-1", "uniprot_id": "DHRS4_RAT", "id": "Q8VID1-1", "name": "Dehydrogenase/reductase SDR family member 4", "aln": "-------MQKAGLLLRGWTRAWKS---------------------------VRMASSGLTRQN----PLANKVALVTASTDGIGLAIARRLAEDGAHVVISSRKQQNVDRAVATLQGEGLSVTGVVCHVGKAEDREKLVNMALKLHQGIDILVSNAAVNPFFGNLMDVTEEVWNKVLSINVTASAMMIKAVVPAMEKRGGGSVVIVSSVAGFVLFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTHFSSVLWKEK-AREEMIKETMQIRRLGKPEDCVGIVSFLCSEDASYINGETVVVGGGTPSRL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99LB2-1", "uniprot_id": "DHRS4_MOUSE", "id": "Q99LB2-1", "name": "Dehydrogenase/reductase SDR family member 4", "aln": "-------MQKAGRLLGGWTQAWMS---------------------------VRMASSGLTRRN----PLSNKVALVTASTDGIGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEGLSVTGIVCHVGKAEDREKLITTALKRHQGIDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTATAMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTRFSSVLWEEK-AREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTPSRL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BTZ2-1", "uniprot_id": "DHRS4_HUMAN", "id": "Q9BTZ2-1", "name": "Dehydrogenase/reductase SDR family member 4", "aln": "-------MHKAG-LLGLCARAWNS---------------------------VRMASSGMTRRD----PLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDK-EKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q8N0-1", "uniprot_id": "F1Q8N0_DANRE", "id": "F1Q8N0-1", "name": "", "aln": "-------MLKAI-TRCLWSNPVAG---------------------------RRMMSHHISQN------LSGKVAIVTASTDGIGLAAAEALGQRGAHVVVSSRRQTNVDKAVSLLRSKNIKVIGTTCNVGKAEDREKLINMTVEQCGGVDILVSNAAVNPFFGNILDSTEEVWDKILGVNVKASFLLTKMVVPHIEKRGGGSVVIVSSVAGYQPMPALGPYSVSKTALLGLTRALAPELAQSNIRVNCVAPGIIKTRFSSALWENEGVLEEFLKQTS-IKRLGQPEEIGGVIAFLCSDEASYITGETITVTGGMNSRL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VRJ4-1", "uniprot_id": "Q9VRJ4_DROME", "id": "Q9VRJ4-1", "name": "", "aln": "MLHLSKQLVVRAPKIRLNASAVSGSGQSSSFDQNSNNYSRKLVGPNLNQCHKRLSSSSQSSTAGTMKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVIRTKFSKALYENESANEAALSKIP-MGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGGGMTARL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . . *: * : *:.***:*********:* *. *.: ** **:***:* *** *:: *: .:.* * *:*.:.***::*. ::. ::*******.** .*.::: *:**:* :.:**.:. :: * .:* :.:: ..*:*:*.*:*.: :..*.******:***: * :** .*****:***:*:* ** *: :: * :.: : *** .*: *:::** *::*.**.**::.. ** :**", "identical_positions": 106, "similar_positions": 95, "identity": "33.33%" }, { "cls_id": "homologset.agr.HGNC:16986", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DBH5-1", "uniprot_id": "LMAN2_MOUSE", "id": "Q9DBH5-1", "name": "Vesicular integral-membrane protein VIP36", "aln": "MAAEAWLWRWGWGWGQRCPGRPGLPGPGPSPTTFLHLLLLLG--PVAADITDGNSEHLKREHSLIKPYQGVGS-SSMPL-------WDFQGSTMLT-SQYVRLTPDERSKEGSIWNHQPC---FLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDR------------------------LVPGPVFGSKDNFHGLAIFLDTYPNDET-TERVFPYISVMVNNGSLS--YDHSKDG-----------RWSELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLP-----TGYYFGASAGTGDLS---DNHDIISIKLFQLTVERTPEEESIDWTKIEPGVNFLKSPKDNV--------------------------------------------------------------------------------------------------------------DDPTGNFRNGPLTGWRVFLLLLCALLGVVVCAVVGAVVFQKRQERNKRFY-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7FPK8-1", "uniprot_id": "F7FPK8_RAT", "id": "F7FPK8-1", "name": "", "aln": "MAAEAWLWRWGWGWGQRCPGRPGLPGPGPGPTTFLHFLLLLG--LVAADITDGNSEHLKREHSLIKPYQGVGS-SSMPL-------WDFQGSTMLT-SQYVRLTPDERSKEGSIWNHQPC---FLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDR------------------------LVPGPVFGSKDNFHGLAVFLDTYPNDET-TERVFPYISVMVNNGSLS--YDHSKDG-----------RWSELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDVTGVRLP-----TGYYFGASAGTGDLS---DNHDLISIKLFQLTVERTPEEESIDWTKIEPGVNFLKSPKDNV--------------------------------------------------------------------------------------------------------------DDPTGNFRGGPLTGWRVFLLLLCALLGIIVCAVVGAVVFQKRQERNKRFY-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q12907-1", "uniprot_id": "LMAN2_HUMAN", "id": "Q12907-1", "name": "Vesicular integral-membrane protein VIP36", "aln": "MAAEGWIWRWGWGR--RCLGRPGLLGPGPGPTTPLFLLLLLG--SVTADITDGNSEHLKREHSLIKPYQGVGS-SSMPL-------WDFQGSTMLT-SQYVRLTPDERSKEGSIWNHQPC---FLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDR------------------------LVPGPVFGSKDNFHGLAIFLDTYPNDET-TERVFPYISVMVNNGSLS--YDHSKDG-----------RWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLP-----TGYYFGASAGTGDLS---DNHDIISMKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDNV--------------------------------------------------------------------------------------------------------------DDPTGNFRSGPLTGWRVFLLLLCALLGIVVCAVVGAVVFQKRQERNKRFY-----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A5PMC4-1", "uniprot_id": "A5PMC4_DANRE", "id": "A5PMC4-1", "name": "", "aln": "MTRERSPALW-------LHPQPSVSRKMPVCHKILLLLWLLHFSSVYSDITDGNAEHLKREHSLIKPYQGVGS-SPSSQ-------WDFWGSTLVT-SQYVRLTPDERSKQGSIWNTVPC---YLKDWEMHVQFKIHGSGKKNLHGDGFAMWYTKER------------------------LHPGPVFGNQDHFVGLAIFVDTFRNDLQGMDRSFPYISAMVNNGSLP--YEHGKDG-----------RSTELGGCSVEVRNKEHDTYLAIRYSKGRLTIMVDVDDQNDWKECVDIGGVRLP-----TGYYFGASAATGDLS---DNHDIISMKMYQLMVEHTLEEDSQDWTKIEPSVSLLKSPKDNI--------------------------------------------------------------------------------------------------------------DDPTGNFRSSPLTGWKVFLLLLCALLGIVVCAVVGAVVFQKRQERNKRFY-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VCC2-1", "uniprot_id": "Q9VCC2_DROME", "id": "Q9VCC2-1", "name": "L-type lectin-like domain-containing protein", "aln": "-----------------------MTKPTREHCSLALLALLVAPFVVLGEDMPREPDYMKREHSLVRPFQGVG--VILPH-------WDFLGNTMVT-SNYIRLTPDLQSKSGALWNYSPV---MTRNWEVHVGFKVHGKG-TELFGDGFAIWYTKER------------------------MQTGPVFGSKDHFSGLAIILDTYSNHNGPHNHQHPYLSAMVNNGSWS--YDHDRDG-----------THTQLAGCEVRFRNVEYETLVSIRYENDILSVSTDLENRNEWKNCFVVANVELP-----TGYHFGMSATTGDLS---DNHDIHSFKFYDLDLNVN-HDEIIRRSNIIPNAKTFEPPREHK--------------------------------------------------------------------------------------------------------------EDPK-----PGMSNAKIFFILLFVVVVAAAVAIFAISYFKDRNAR-KRFY-----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12396-1", "uniprot_id": "EMP46_YEAST", "id": "Q12396-1", "name": "Protein EMP46", "aln": "--MTTRKTASSLQLLGKITGTKAGTKQKKMNFINGLIWLYMCVWMVHGKVTQKDELKWNKGYSLPNLLEVTDQQKELSQ-------WTLGDKVKLE-EGRFVLTPGKNTK-GSLWLKPEY---SIKD-AMTIEWTFRSFGFRGSTKGGLAFWLKQ-----------------------------GNEGDSTELFGGSSKKFNGLMILLRLDDKLGESVTAYLNDGTKD--LDIE--------------SSPYFASCLFQYQDSMVPSTLRLTYNPLDNHLLKLQMDN---RVCFQTRKVKFMG---SSPFRIGTSAINDASK---ESFEILKMKLYDGVIEDSLIPNVNPMGQPRVVTKVINSQTGEESFREKMPFSDKEESITSNELFEKMNKLEGKIMANDIDPLLRKMNKIVENERELIQRLRPLLDLKKT--------------AISDD--SFQDFLSMNANLDRLIKEQEKIRQDAKLYGKQTKGHDEIFSKISVWLALLIFIMITLAYYMFRINQDIKKVKLL----------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P43555-1", "uniprot_id": "EMP47_YEAST", "id": "P43555-1", "name": "Protein EMP47", "aln": "--MMMLITMKSTVLLSVFT----------------VLATWAGLLEAHPLGDTSDASKLSSDYSLPDLINAR---KVPNN-------WQTGEQASLE-EGRIVLTSKQNSK-GSLWLKQGF---DLKD-SFTMEWTFRSVGYSGQTDGGISFWFVQD----------------------------SNVPRDKQLYNGPVN-YDGLQLLVDNNGPLGPTLRGQLNDGQKP--VDKTKI------------YDQSFASCLMGYQDSSVPSTIRVTYDLEDDNLLKVQVDN---KVCFQTRKVRFP----SGSYRIGVTAQNGAVNNNAESFEIFKMQFFNGVIEDSLIPNVNAMGQPKLITKYIDQQTGKEKLIEKTAFDADKDKITNYELYKKLDRVEGKILANDINALETKLNDVIKVQQELLSFMTTITKQLSSKPPANNEKGTSTDDAIAEDKENFKDFLSINQKLEKVLVEQEKYREATKRHGQDGPQVDEIARKLMIWLLPLIFIMLVMAYYTFRIRQEIIKTKLL----------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P36137-1", "uniprot_id": "UIP5_YEAST", "id": "P36137-1", "name": "Protein UIP5", "aln": "--------------MSRDVRAEKLAISLLILSLFLIFQLVAEIYLNNGDQYHTETSPFTRGRSHVTRVPNHDASLSIPFLDKINQFWHVGGATQIRNIQSIKLTQDRDQDKHGLVLSNGIGDNTINDFEIVFTFRISHDPTTQLTGDGMCFAITPENGFLTQNLQSSYAKKQYMMNSQGVIADNTDLMGFPKNLPGLFIVLDTYR-NQGHDHKEVPFMDVFINVAPESDWYDINSDGELSTSLRLNSRGHIKLKKNALWNRVTKLRIIYLESISFLKIDVQYAKEGNYWIELFQTTENLYLPKNMHTGQRYIGCSALNGQLT---ETVELLDVSTSEFHWNDMDASIEDTYDYAKEAELFLEQEFGEVLDREPDEFTKWKMIKAQPN------------------------------------------------------------------------------IKTGSQSAEQKTSNNPHSRLFKVVLTIWHYSEILLLIMGIYLFSACIRVFQRRFKKIRSRRKRAGSHSVGLLPM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . * * . : . ** . .: .: . . : . .*:.: . * : : :* . : : : . : .. . : : :* :* .. . :. :: ... : : :. . : . : : . : .: : ", "identical_positions": 9, "similar_positions": 60, "identity": "1.67%" }, { "cls_id": "homologset.agr.HGNC:16987", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CX34-1", "uniprot_id": "SGT1_MOUSE", "id": "Q9CX34-1", "name": "Protein SGT1 homolog", "aln": "MAAAAAGPASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGK-YRDGIADVKKSLELNPNNCTALLRKG---------------ICEYHEKDYASALETFAEGQKLD--------------------------------STDTNFDTWIKRCQEIQNGSES----------EVSASQRTQSKIKYDWYQTESHVIITLMIKSVQKNDVRVGF-----SERELSALVKIP-AGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTP-----------KQFTADVKNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQY--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B0BN85-1", "uniprot_id": "SGT1_RAT", "id": "B0BN85-1", "name": "Protein SGT1 homolog", "aln": "MAAAAAGPASSQRFFQSFPDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGK-YCDGIADVKKSLELNPNNSTALLRKG---------------ICEYYEKDYASALETFAEGQKLD--------------------------------GTDTNFDIWIKRCQEIQNGSEP----------EVSASQRTQSKIKYDWYQTESHVIITLMIKNVQKNDVRVDF-----SEKELSAVVKIP-SGEDCSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDVPAP-----------KQFTADVKNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQY--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y2Z0-1", "uniprot_id": "SGT1_HUMAN", "id": "Q9Y2Z0-1", "name": "Protein SGT1 homolog", "aln": "MAAAAAGTATSQRFFQSFSDALIDEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGN-YCVAVADAKKSLELNPNNSTAMLRKG---------------ICEYHEKNYAAALETFTEGQKLDIETGFHRVGQAGLQLLTSSDPPALDSQSAGITGADANFSVWIKRCQEAQNGSES----------EVWT---HQSKIKYDWYQTESQVVITLMIKNVQKNDVNVEF-----SEKELSALVKLP-SGEDYNLKLELLHPIIPEQSTFKVLSTKIEIKLKKPEAVRWEKLEGQGDVPTP-----------KQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKNEKLEGDAALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VHT3-1", "uniprot_id": "Q9VHT3_DROME", "id": "Q9VHT3-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVRHDWYQSETKVVITVLLKNAVDKNYAVEI-----TQK----RVHMT-ADG-YELDLKLLHPIVVERSSYKAFSTKVEITLAKETGIRWENLEEA------------------IVAAPVK-------PKAKNWDQLVSEEEKIDEKE-AKGEAALTNLFKKIYSSSSPEVQKAMNKSFSESGGTVLSTNWNEVGKERVTVKPPNGTEFREWEK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q08446-1", "uniprot_id": "SGT1_YEAST", "id": "Q08446-1", "name": "Protein SGT1", "aln": "-------MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTALIFKAACLEKLYFGFSDWHSDATMENAKELLDKALMTAEGRGDRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLG---------YVDDTLPLWEDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTSVTISLFTVNLPESKEQVNIYISPNDRRTLSISYQVPKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEAGSADSFFQKLYAGADPDTKRAMMKSFIESNGTALSTDWEDVSKGTVKTSPPEGMEPKHW--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..: ****:.: * *::: . ... * : .: ::. :. . . .* * : : : * :..*:**.: * . :*::** .: . . .: :. : .:* : .: :*:::*:... :.::** *** **.**.***:*.:*.* * .**:. * :.: ", "identical_positions": 39, "similar_positions": 75, "identity": "9.44%" }, { "cls_id": "homologset.agr.HGNC:16988", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AB60-1", "uniprot_id": "A0A8I6AB60_RAT", "id": "A0A8I6AB60-1", "name": "", "aln": "MRCSHALLNVDGMTCLKVENLAYHTSSYTLKLIFEDYGAVGDVFVPRNHLTEENYGFAFIHFYNNCDAKDAMHGLHGILLDGNKLKVQMVHNDDLHYAQPDCGHGRQYHYEEENHELQKQYKRQHCSNTRIQTRSQSRLSPDNSESKSQSCNHSHRKSASTNGSTTQSSLSTQKLPNRACPKSRNRPGEKKKPKSKSSCKSVSKYPSGGGCLVIENMETKQNQVENVQSKSVFKKSCRSKGNAAHTLMASPSTTSQKRKRCRSPQNLRESPRLERKHVESNQRQMEYPQSESIIIKNCLSKEIELEMLTVYDRSQRTRRSSQGLPSNNSNRCGANTAHVLNSGDSERGQLNSLQQSEKGMKMGIRECGFWTAKSQSNPSNNDITGEVRFTFNKGNSNPQNDLSGLSCHDNNRKVQKQVDYQQPESTCVSPFTKEGNITEVLVEDTFSKDRSTRSKSPDMLILKETIESRLLPETKDMELVETHHCLSPETFKDLRKDEAYFSSNSHTFLPLRDDLNISELRKLYFFASFPTREHILTESTAHRSQTTSVTPTNFTTVEIDQKDTNLSSCYNQTGIQNSEKKSDEILKTNLDFTIVTTPCGTAGNIMTGVFEVNDNFTEIDLESCDSLASQSNRKVQSGHSNISSSVSITNSNSTSNSNINNSLLSLLNYSQQFLPVPNIIANNTIGNDINSPHTSQINKECDEFFLFHYPPLEARQQMHVISPEISNDSDSWPLLPDFSNFNDIHNNHPKGLTKEQINTLPVKTFCENDKLNHCSICITPYTQNSKIRVLPCFHEYHDKCIDRWLSDNSTCPICRKQIINPDDMEFLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BRL6-1", "uniprot_id": "SRSF8_HUMAN", "id": "Q9BRL6-1", "name": "Serine/arginine-rich splicing factor 8", "aln": "MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRS-PRRRHRSRSRG-PSCSRSRSRSR---YRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSR------------YHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSP-----------------------------------------------------EEEGQMSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *.:. :**** ***:**:*:**. :*: :**.** ****::**: *: ****::*::. **:** .:.* ***.:*:**:.: . . .:. *. * . .:.* *: * .* : **:** *. *.*:*:* :* * :... ::*. * .: .. . .:** * .. .: .** * *:*. :.. .: :* * .. . *..::: : :..*:.*:.*.*.**.. *..**:.::: :*..*. . *:* .*.**:.* ", "identical_positions": 89, "similar_positions": 114, "identity": "10.75%" }, { "cls_id": "homologset.agr.HGNC:16989", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60762-1", "uniprot_id": "MO4L1_MOUSE", "id": "P60762-1", "name": "Mortality factor 4-like protein 1", "aln": "-----------MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDK--------------------------------------QVKYFIHYSGWNKKSAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYA------EGKMRGAAPGKKTSGLQQKN-----------------------------------------------VEVKTKKNKQKTPGNGDGGSTS--------------ETPQPPRKKRAR----------------------------VDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKS-RGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAP----MSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASD--------YEVAPPEYHRKAV--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UBU8-1", "uniprot_id": "MO4L1_HUMAN", "id": "Q9UBU8-1", "name": "Mortality factor 4-like protein 1", "aln": "-----------MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDK--------------------------------------QVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYA------EGKMRGAAPGKKTSGLQQKN-----------------------------------------------VEVKTKKNKQKTPGNGDGGSTS--------------ETPQPPRKKRAR----------------------------VDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKS-RGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAP----MSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASD--------YEVAPPEYHRKAV--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6AYU1-1", "uniprot_id": "MO4L1_RAT", "id": "Q6AYU1-1", "name": "Mortality factor 4-like protein 1", "aln": "-----------MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDK--------------------------------------QVKYFIHYSGWNKN---------------------------------------WDEWVPESRVLKYVDANLQKQRELQKANQEQYA------EGKMRGAAPGKKTSGLQQKN-----------------------------------------------VEVKTKKNKQKTPGNGDGGSTS--------------ETPQPPRKKRAR----------------------------VDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKS-RGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAP----MSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASD--------YEVAPPEYHRKAV--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A8E7S8-1", "uniprot_id": "A8E7S8_DANRE", "id": "A8E7S8-1", "name": "Mortality factor 4-like protein 1", "aln": "-----------MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKINIKDK--------------------------------------QVKYFIHYSGWNKN---------------------------------------WDEWVPESRVLKYVDSNLQKQKELQKANQDHYV------EGRMRGVAPSKKIAAVQQKN-----------------------------------------------VDVKTKKNKQKTPGAGEGTSTG--------------DMPHPPRKKRAR----------------------------VDPTVESEETFINRVEVKVKIPEELKPWLVDDWDLITRQKQLFHLPAKKNVDAVLEDYANYKKS-RGNSDNKEYAVNEVVAGIREYFNVMLGTQLLYKFERPQYAEILANHPDTS----MSQIYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLSYLQDFLKYLVKNSSSLFSASD--------YEVAPPEYHRKAV--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9Y0I1-1", "uniprot_id": "EAF3_DROME", "id": "Q9Y0I1-1", "name": "NuA4 complex subunit EAF3 homolog", "aln": "MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDAT--------------------------------------PVEYYIHYAGWSKN---------------------------------------WDEWVPENRVLKYNDDNVKRRQELARQCGERSK------KDNKKGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTP----LSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSN--------FINVDPEYVRNAQ--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12432-1", "uniprot_id": "EAF3_YEAST", "id": "Q12432-1", "name": "Chromatin modification-related protein EAF3", "aln": "--------------MVDLEQEFALGGRCLAFHGPLMYEAKILKIWDPSSKMYTSIPNDKPGGSSQATKEIKPQKLGEDESIPEEIINGKCFFIHYQGWKSS---------------------------------------WDEWVGYDRIRAYNEENIAMKKRLANEAKEAKKSLLEQQKKKKLSTSLGGPSNGGKRKGDSRS-----------------------------NASISKSTSQSFLTSSVSGRKSGRSSANSLHPGSSLR----------SSSDQNGNDDRRRSSS---------------------------LSPNMLHHIAGYPTPKISLQIPIKLKSVLVDDWEYVTKDKKICRLPADVTVEMVLNKYEHEVSQ-ELESPGSQSQLSEYCAGLKLYFDKCLGNMLLYRLERLQYDELLKKSSKDQKPLVPIRIYGAIHLLRLISVLPELISSTTMDLQSCQLLIKQTEDFLVWLLMHVDEYFNDKDPNRSDDALYVNTSSQYEGVALGM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : * * * *.*****:**** :* . ::*** **... ***** .*: * : *: ::.* . : : . . : . :.:. . :*. :.:.. :. : ::* * : . : ::.::** :** *.*** :.::::: ***. .*: : :.* .. . : ..: :.: *: **: **. ***::** ** ::: . .. .:**: *****: : ::: :.:* :* *:. .*** :* : *. .: : . .:* * ", "identical_positions": 74, "similar_positions": 109, "identity": "14.2%" }, { "cls_id": "homologset.agr.HGNC:1699", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8J8XPU7-1", "uniprot_id": "A0A8J8XPU7_RAT", "id": "A0A8J8XPU7-1", "name": "B-cell antigen receptor complex-associated protein beta chain", "aln": "MKLPSRVPGEMVPPLGLNLHGRKGPNGEEVERRKVAARADTQLHVLPQTLLGLRDRAVTMATLVLSPVPCHWLMFLLLLLSGEPVPAMTKSDQPPIFQGSPCSKIWQHPRFAAKKRSSMVKFHCHTD----YSGVMTWFRQKGN-QRPQELFPEDGHISQTRNGSVYTLTLQNIQYEDNGIYFCQQKCNSTEPDVTDGCGTELLVLGFSTLDQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSK----AGMEEDHTYEGLNIDQT--ATYEDIVTLR-TGEVKWSVGEHPGQE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P15530-1", "uniprot_id": "CD79B_MOUSE", "id": "P15530-1", "name": "B-cell antigen receptor complex-associated protein beta chain", "aln": "-----------------------------------------------------------MATLVLSSMPCHWLLFLLLLFSGEPVPAMTSSDLPLNFQGSPCSQIWQHPRFAAKKRSSMVKFHCYTN----HSGALTWFRKRGS-QQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCDSANHNVTDSCGTELLVLGFSTLDQLKRRNTLKDGIILIQTLLIILFIIVPIFLLLDKDDGK----AGMEEDHTYEGLNIDQT--ATYEDIVTLR-TGEVKWSVGEHPGQE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P40259-1", "uniprot_id": "CD79B_HUMAN", "id": "P40259-1", "name": "B-cell antigen receptor complex-associated protein beta chain", "aln": "-----------------------------------------------------------MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNS---ASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTS-EVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSK----AGMEEDHTYEGLDIDQT--ATYEDIVTLR-TGEVKWSVGEHPGQE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4ID76-1", "uniprot_id": "A0A0R4ID76_DANRE", "id": "A0A0R4ID76-1", "name": "", "aln": "-------------------------MSVLICMFLRSIFTALDLHLLAEAGLCSG-ELYSFCSLSVTDVYITFRGGFEDFNIMHHFLLGFSVMALIYLSAEGSIIVFQKPRFIGVKTGRTVIIYCVPSNPTRGPARVQWFKNKNY--QSSLTNDQRITINDRNNDKNASITLKKVETEDSGTYVCKLND-------TFGPGTALQVSRYSEPHAVLMRSRVKDVIIFLQAFLLVLCIVVPLVRLYKLEKKEEAEYEEPEDDHIYEGLEIEQVGGDVYEDISTFAQSSDAAWQV-ESPCQE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. * :: : : : : . . . ... . ::* *** . * . * ::* . .. : *: :: ... : : : .* . ::*:: :. **.* *.*: : . ** * * :* : *. :** **::*::*::* *:**:. * . :. : *:** ****:*:*. .**** *: :.:. *.* * * **", "identical_positions": 53, "similar_positions": 75, "identity": "17.73%" }, { "cls_id": "homologset.agr.HGNC:16990", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O00193-1", "uniprot_id": "SMAP_HUMAN", "id": "O00193-1", "name": "Small acidic protein", "aln": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDDDDDDSPDPESPDDSESDSESEKEESAEELQAAEHPDEVEDPKNKKDAKSNYKMMFVKSSGS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9R0P4-1", "uniprot_id": "SMAP_MOUSE", "id": "Q9R0P4-1", "name": "Small acidic protein", "aln": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDEDD--SPDAESPDDSDSDSESEKEESAEELHAAEHPDDTEDPKSKKDAKSNYKMMFVKSSGS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LGJ9-1", "uniprot_id": "A0ABK0LGJ9_RAT", "id": "A0ABK0LGJ9-1", "name": "Small acidic protein", "aln": "MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDEDD--SPDAESPDDSDSDSESEKEESAEELHAAAHPDDTEDPKSKKDAKSSYKMMFVKSSGS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7ZVC9-1", "uniprot_id": "SMAP_DANRE", "id": "Q7ZVC9-1", "name": "Small acidic protein", "aln": "MSSSDEPC-KGTKRPASPDE-TGSTQWQSADLGTDERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRSGAEDRRMNADLEHQYQQSLDGKLSGRNRRHCGLGFSEPDEVAESPNAAVSETSNS-----SETPPEQVSETQKEEKPPASDTELEKPEPHT---HSKEDKKKTLKMAFVKST--", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:: *. :*.**.****: **::*::****.:*********************************:* **:::* :** *****:*.***** ********** :: . :.* .: .:. .*:* :. *:::.*:: .*.: . .. :.*:* *.. ** ****: ", "identical_positions": 92, "similar_positions": 52, "identity": "50.27%" }, { "cls_id": "homologset.agr.HGNC:16991", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZH41-1", "uniprot_id": "D3ZH41_RAT", "id": "D3ZH41-1", "name": "", "aln": "MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPPAPQQPQPP-----APHPPQHPQNQAH-RGGHRG------RSS---------TAAAAASSASCSRRLGRLLNFLFYLSLVAAAAFSGWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQAAVGTFESILRSSQHKQDLTEKAVKEGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKVLKEAVKEVQASMKSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTEKLLQSEESSSRLPEDIRRLEEELQQLKVGAHGSEEAVVFRDSKAFDELQKQMEGLGARLQYVEDGVYSMQVASASHTESLESLLSKSQEYEQRLAMLQEHVESLGPI----SDLASTVRSLEETQLALSSDLKGLKQGLGELPGTVESLQ---EQVHLLLSQDPAQAAGLPPQDFLDRLSSLDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENSLESAKGLLDDLRNDLDRLFVKVEKIHEKI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BMK4-1", "uniprot_id": "CKAP4_MOUSE", "id": "Q8BMK4-1", "name": "Cytoskeleton-associated protein 4", "aln": "MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPAAPQQPQPP-----APHPPQHPQNQAH-RGGHRG------RSS---------AATANASSASCSRRLGRVLNFLFYLSLVAAAAFSGWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQATFGTFESLLRNSQHKQDLTEKAVKEGESELNRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKTLKDAVKEVQASMMSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTEKLLRSEESSSRLPEDIRRLEEELQQLKVGAHGSEEGAVFKDSKALEELQRQIEGLGARLQYVEDGVYSMQVASARHTESLESLLSKSQEYEQRLAMLQEHVGNLGSS----SDLASTVRSLGETQLALSSDLKELKQSLGELPGTVESLQ---EQVLSLLSQDQAQAEGLPPQDFLDRLSSLDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFLKVEKIHEKI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q07065-1", "uniprot_id": "CKAP4_HUMAN", "id": "Q07065-1", "name": "Cytoskeleton-associated protein 4", "aln": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNK-QDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*******************:*****************.***** ** ** ******** :***** :** :*:* :*********** *******:********** *************.********:******************:.*****:**.*************:****:.**********************************************************:**********::* ********:*:: **:*.**:****:*:* *** *:***:*:*******:******************:***:*************:**** *****:********:*** .:**.:* *:.*:*:: **:: :**.:***:***** ******* :*************:***** ** :: .**. ..******** ****.* .*:: **:.:****.****** *** ***** *** *****************:******:************************.*******************:********:", "identical_positions": 469, "similar_positions": 73, "identity": "77.78%" }, { "cls_id": "homologset.agr.HGNC:16992", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U308-1", "uniprot_id": "LRC8D_RAT", "id": "Q5U308-1", "name": "Volume-regulated anion channel subunit LRRC8D", "aln": "MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTPPGNADVTTEVPKMETATPQDQNGQ-TTNDIAFGTSAVTPDIPLQATYSHAESTFPSQETKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDVLPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLPLEVKEALNQDVNVPFANGI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGR2-1", "uniprot_id": "LRC8D_MOUSE", "id": "Q8BGR2-1", "name": "Volume-regulated anion channel subunit LRRC8D", "aln": "MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTPPGNADITTEVPRMETATHQDQNGQTTTNDVAFGTSAVTPDIPLQATHPHAESTLPNQEAKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLPLEVKEALNQDVNVPFANGI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7L1W4-1", "uniprot_id": "LRC8D_HUMAN", "id": "Q7L1W4-1", "name": "Volume-regulated anion channel subunit LRRC8D", "aln": "MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGR-TTNDISFGTSAVTPDIPLRATYPRTDFALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFANGI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BG09-1", "uniprot_id": "A0A8M2BG09_DANRE", "id": "A0A8M2BG09-1", "name": "", "aln": "MFTLTEVASLNDIQPTYKILKPWWDVFMDYLGVVMLMLAIFAGTMQITKDQVVCLPVLESLED--------QAPVPTERPPGKAFGSGTGGGHVTLAAAPLASNEQT---------DSVVQHFPQSSAVRQPQ-PTGLRTNLDFQQYVFVNQMCYHVALPWYSKYFPYLALIHTIVLMVSSNFWFKYPKTSSKIEHFVSILGKCFESPWTTKALSETACEDSEENKQRLTGASTLPKHLSTSSEEGSPNQSTPMLAKSSIKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRTHVEDSDTIYKLYVAQTIIKTVKFILILCYTMTFVTSIKFDHDCEPEIKHLTGYNKFKCTHNMAFMLKKLLVSYIVLIFVYGLVCIYTLFWLFRRPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVTRNAQDKLELHLFMLSGVPDAVFDLTDIEVLKLELIPEARITAKISQMINLTELHFYHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPTWVYMLKNLRELYLVGNLNSENNKMIGLESLRDLRHLKVLHLKSNLTKIPTNITDLSPHLIKLVVHNDGTKLLVLNSLKKMMNLSDLELHNCELERIPHAIFSLTNLQELDLKSNNIRTIEEVISFQHLKRLNCLKLWHNKIISIPMSISHVKNLEFLYLSHNKLESLPTTLFNLLKLRYLDVSHNSIVVIPPEVGFLQNLQHFAITGNKVEVVPKQLFKCTKLRTLSLGHNCISSLPEKIGQLLQLTHLELKGNCLDRLPAQLGQCRLLRRNGLTVEDHLFDSLPLEVKESISQEITATYANGV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A2BIH6-1", "uniprot_id": "A2BIH6_DANRE", "id": "A2BIH6-1", "name": "", "aln": "MFSLTEVASLNDIQPTYRILKPWWDVFMDYIGVIMLMLAIFSGTMQLSKDQVACLPILEKNIN---------LEGAQNRP--ECSLSVLGTGPSTTKDLPDSVANELLN--------TQPAPLPKEGVWTQPQ-PTGVKTNLDFQQYVFVNQKCYHDALPWFNKYFPYLALIHTIMLMVSSNFWFKYPKTSSKIEHFVSILGRCFESPWTTKALSETACEDSEGNKQRFTGGSVYHKHVSSED-----SQSTPLVETPTAPFSTEKLIAEAPSLTTLDKKDGEQAKALFEKVRKFRAHVEDSDFIYKLYVAQTAIKALKVILILSYTSTFAAEISFCHICKPKVESLTGYDQFFCTHNMAFMLRKLLFTFMAMICLYGLVCLYTLYWLFRRPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSTNAQEEQELHLFMLSGLPNAVFDLTDLEILKLELIPEVRISAKVSQMTNLRELHLYHCPAKVEQTAFTFLRDHLRCLHIKFTDVAEIPPWIYLLRSLKELNLFGNLNSEHNKMIGLESLRDLRHLRTLYLKSNLNKIPSNLTDLSPHLVKLVIHNDGTKLLVMNSLKKMTSLVDLELHNCDLERIPHSIFSLANLQELDLKNNNIRTIEEIISFQHLRRLVCLKLWYNKISIIPPSIGLVKSLESLIICHNKVENLPPSLFHLPKLRHIDLSNNSISNIPVEIGLLHNLQHFAITGNKVEVLPSQLFKCSKLKVLCVGHNNITSIPDSIGQLVQLSHLELKGNCLDCLPFQLGQCQLLRKNLLFVEDHLFDTLPIEVKDSMSSD---------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:*:************:************:.*:***:***:****::****.***:* . : . : * : * * . . :*.. . : : *** :**********:** *** ****:.************:**************.**:********:******************** ****:**... **:*:.. . ***:: .. **:** : *.**:* ********************:****** ******.** **: *.*:**.** .*. *.* * *:*::: * **: * ******:**:***.::: :* :**::*:***:**** *************************************************************************:: ***:: *********:*:*******:::********.:*.**:*** ** ***: ***********:**********:*********.*:*:*:.*:** *.******:**********:****: *::****.*:*:*:**::*** ***:*********:****** .: :***:**:******:****:********.*.******:******:** *****:*** ** ** **.** * :.:**:*.** ::* * *** :*:* *.* ** *:*:*:****: ******:::*.***** **:.* :*:* *:*:*:.:.** **::********* ** *****::*::. * ***:***:**:***:::..: ", "identical_positions": 553, "similar_positions": 169, "identity": "64.38%" }, { "cls_id": "homologset.agr.HGNC:16993", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CQS8-1", "uniprot_id": "SC61B_MOUSE", "id": "Q9CQS8-1", "name": "Protein transport protein Sec61 subunit beta", "aln": "MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIAAVFMLHIWGKYTRS--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LXI6-1", "uniprot_id": "A0ABK0LXI6_RAT", "id": "A0ABK0LXI6-1", "name": "Protein transport protein Sec61 subunit beta", "aln": "MPGPTPSATNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P60468-1", "uniprot_id": "SC61B_HUMAN", "id": "P60468-1", "name": "Protein transport protein Sec61 subunit beta", "aln": "MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P52871-1", "uniprot_id": "SC6B2_YEAST", "id": "P52871-1", "name": "Protein transport protein SBH2", "aln": "MAASVPPG------GQ---RILQKRRQAQSIKEKQAKQTPTSTRQAGYGGSSSSILKLYTDEANGFRVDSLVVLFLSVGFIFSVIALHLLTKFTHII-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P52870-1", "uniprot_id": "SC6B1_YEAST", "id": "P52870-1", "name": "Protein transport protein SBH1", "aln": "MSSPTPPG------GQ---RTLQKRKQGSS--QKVAASAPKKN-----TNSNNSILKIYSDEATGLRVDPLVVLFLAVGFIFSVVALHVISKVAGKLF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*....*.. *: : : * ..: :: . . . ....: ::*:::: *::*..: **.::: ** :*. **: * : ", "identical_positions": 15, "similar_positions": 41, "identity": "15.31%" }, { "cls_id": "homologset.agr.HGNC:16994", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5RKH6-1", "uniprot_id": "OS9_RAT", "id": "Q5RKH6-1", "name": "Protein OS-9", "aln": "--MAAEALLSSLLGLLFLGLLLPAHLTGGVGS--LNLEELSEMRYGIQILP-LPVMGG---QSQASDVVVVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGDVLYLGYYQSAFNWDDETAKASKQHR--------LKRYHSQTYGNGSKCDLNGKPREAEVRFLCDEGAGISGDYIDRVDEPFSCSYVLSIRTSRLCPHPLLRPPASAAPQAILCHPALQPDEYMAYLQRQAESKQHEEKVTEEVQDTDHQVWSGSKAAGAPPKKEDVSPTKED-KESEFWKMLQEPEEQATGTEEAQAGEQDLNHEAAADPAPAPPTDFQNNVQVKLIRSPADLIRLIEELKG-AEKGKPSVRQEQPGDDTTEAPQREAE---AKGKGGEPRGLVEEEDGD----EEEEDEDEDEQQLLGEFEKELEGMLLPSDRERLRSEVKAGMERELENIIQETEKELDPEGLRKESEREQAILALTSTLDKLIKRLQESQSPELVQKYKKRRVVPQKPPPSPHPTEEEPEHRVRVRVTKLRHGGPNQDLTVLEMNRENPQLKQIEGLVTEVLEREGLTAEGKIEIKIVRPGAEGKEEDTRWLTDEDTRNLKEIFFNILVQGAEEANKERQRQSELESNYRRVWGSPGGEDTGDLDEFDF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K2C7-1", "uniprot_id": "OS9_MOUSE", "id": "Q8K2C7-1", "name": "Protein OS-9", "aln": "--MAAEVLLSSLLGLLFLGLLLPARLTGGVGS--LNLEELSEMRYGIQILP-LPVMGG---QSQASDVVVVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGDVLYLGHYQSSFNWDDETAKASKQHR--------LKRYHSQTYGNGSKCDLNGKPREAEVRFLCDEGAGISGDYIDRVDEPVSCSYVLTIRTSRLCPHPLLRPPASAAPQAILCHPALQPDEYMAYLQRQAESKQHEEKTTEEVQDTDRQVWSGSKAAGAPPKKEDVSPAKEE-KESELWK-LQGPEEQAAAREEAQAGEQDLNHEAAADPAPSPPNDFQNNVQVKLIRSPADLIRLIEELKA-AEKGKPSVRREQPGDDTTEAPQREAEGTKAKGKDGEPPGLMEEEDGDDEEEEEEEEEDEEEQQLLGEFEKELEGMLLPSNRERLRSEVKAGMERELENIIQETEKELDPEGLRKESEREQAILALTSTLDKLIKRLQENQSPELVQKYKKRRVVPQKPPPSPHPTEEEPEHRVRVRVTKLRPGGPNRDLTVLEMNRENPQLKQIEGLVTEVLEREGLTAEGKIEIKIVRPGAEGKEEDTRWLTDEDTRNLKEIFFNILVQGAEEANKERQRQSELESNYRRVWGSPGGEDTGDLDEFDF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13438-1", "uniprot_id": "OS9_HUMAN", "id": "Q13438-1", "name": "Protein OS-9", "aln": "--MAAETLLSSLLGLLLLGLLLPASLTGGVGS--LNLEELSEMRYGIEILP-LPVMGG---QSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHR--------LKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPE-AADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPE--KERGDPERQREMEEEEDED-----EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99220-1", "uniprot_id": "OS9_YEAST", "id": "Q99220-1", "name": "Protein OS-9 homolog", "aln": "MQAKIIYALSAISALIPLGSSLLAPIEDPIVSNKYLISYIDEDDWSDRILQNQSVMNSGYIVNMGDDLECFIQNASTQLNDVLEDSNEHSNSEKTALLTKTLNQGVKTIFDKLNER-CIFYQAGFWIYEYCPGIEFVQFHGRVNTKTGEIVNR---DESLVYRLGKPKANVEEREFELLYDDVGYYISEIIGSGDICDVTGAERMVEIQYVCGG-SNSGPSTIQWVRETKICVYEAQVTIPELCNLELLAKNE-------------DQKNASPILCRMPAKSKIGSNSIDLITKYEPIFLGSGIYFLRPFNTDERDKLMVTDNAMSNWDEITETYYQKFG---------NAINKMLSLRLVSLPN--------GHILQPGDSCVWLAEVVDMKDRFQTTLSLNILNSQRAEIFFNKTF-------------TFNEDNGN--------------------FLSYKIG--------------DHGESTELGQITHSNKADINTAEIRSDE-------YLINTDNELFLRIS--KEIAEVKELLNEIVSPHEMEVIFENMRNQPNNDFELALMNKLKSSLNDDNKVEQINNARMDDDESTSHTTRDIGEAGSQTTGNTESEVTNVAAG------VFIEHDEL----------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **:: .*: ** * * : . : * :. :.* :. .** .**.. . ..*: . .: . : : * . * : *: . . *: ::. :.: *:: .:* **:* * .: *:* . . .*::: :.:: : ..**. :.* : * *: *.*. **:.* * .*::::*. :. . . *: * *. * * : ..** ** : .: . : * . ..: .: : : . . . * : . : . *. : . * . : : : . *. * .*.* : *: .: :..: : .: :* .:. :*:: : * . * . * . ** :* :..: :::. ::.:. * .* ::*: *:. :. *:: :. * *:: . .::*:: ..: : : .. * * .* :::. . : .: . ... : . * : *: * ::.. * :: .:: ", "identical_positions": 81, "similar_positions": 204, "identity": "11.72%" }, { "cls_id": "homologset.agr.HGNC:16995", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LPI3-1", "uniprot_id": "F1LPI3_RAT", "id": "F1LPI3-1", "name": "Gap junction protein", "aln": "MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSSFACNTQQPGCSNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFEKQRQKKKLYLKAQMENPDLDLEEQQRVERELRRLEEQKRIQKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGAQQCMVCSSLPERVSLLQANNKQQVIRVNIPRSKSVWQIPHPRQLEVDVS-CGKRGWAERVENSEQLHVHSPCPHERSARIQHPGQQPCHSIVCPKNVMSQSWLGTMTASQHRPSSALETWERSQGPEVSGKPLTDRQSHFQGSDGSARESGVWTDRLGPGSRKASFLSRLISEKGQQHSDSGSSRSLNSSCLDFPHGENSP-SPLPSATGHRASMVSSSSS----IHSRTLHG---YTTVHFGRVSFATSVT--------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WUS4-1", "uniprot_id": "CXA10_MOUSE", "id": "Q9WUS4-1", "name": "Gap junction alpha-10 protein", "aln": "MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSAFACNTQQPGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFEKQRQKKKLYLRAQMENPELDLEEQQRVDKELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNSVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGTQQCMICSSLPERISLLQANNKQQVIRVNIPRSKSMWQIPHPRQLEVDVS-CGKRDWAEKIESCAQLHVHSPCPHDRSARIQHPGQQPCHSVFGPKNAMSQSWFGTMTASQHRPSSALETWERSQGPEASGRSLTDRQSHFQGSDGSARESGVWTDRLGPGSRKASFLSRLMSEKGQRHSDSGSSRSLNSSCLDFSHGENSP-SPLPSATGHRASMVSKSSH----VDS-PPHS---SFIIHETYVYVY------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969M2-1", "uniprot_id": "CXA10_HUMAN", "id": "Q969M2-1", "name": "Gap junction alpha-10 protein", "aln": "MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMENPDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSKTMWQIPQPRQLEVDPS-NGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSP-SPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVKFNS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58I2B7-1", "uniprot_id": "A0AC58I2B7_DANRE", "id": "A0AC58I2B7-1", "name": "Gap junction protein", "aln": "MGDWNLLGSILEEVHIHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSEFVCNTEQPGCKNVCYDQAFPISLIRYWVLQIIFVSSPSLVYMGHALYRLRALEKERHKKKVQLKVELEESE-ALEEHKRIEKELRKLEEQKKVRKAPLRGSLLRTYVFHILTRSVVEVGFIVGQYMLYGIGLTPLYKCERDPCPNSVDCFVSRPTEKNIFMIFMLVISGVSLFLNLLEIFHLGVKKIKQTIYGSMYS----DDDSICRSKKNSMVQQVCFLTNSSPQKQLHLTHTSLAMAPDGQMVPLPIY--MQTAGHVVSNINPNGSVQPLRQDRLPSQPEIQVLQQLGIKERRSIPDNRLQSCSS--EDSGPKGSEPPKYSQQPRASFRASHIEIPAALR-KHSRVSQCKDFSEES-DSVESG------NYPTARKASFMSRGLSES---PSESAASKSGSDTEANRITQGESPAMTPPPAAGRRMSMVKFFFPLRCRHWLAWFRIGRATHRWICSSVFELSVMIKSH-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9P085-1", "uniprot_id": "A0A8M9P085_DANRE", "id": "A0A8M9P085-1", "name": "Gap junction protein", "aln": "MGDWNLLGSILEEVHIHSTIVGKIWLTILFIFRMLVLGVAAEDVWVDEQSEFVCNTDQPGCKNVCYDQAFPISLIRFWVLQIIFVSSPSLVYMGHALYQLRSLEKERHRRKIQLRAELEETEPLLEEHRKLEKELRRLEEQKKMKKAPLRGSLLRTYIIHILTRSVVEVAFIVGQYILYGIGLDPLYKCERVPCPNSVDCYVSRPTEKTIFMVFMIVIAGVSLFLNLLEISHLGVRKIKQTLSGLQFV----EEDSLCKP-KHSTIQQLCVMTEYSPHKNPQLKTFIPQGQMDKHLFSSSSNDILRHNSLAASTLPVSCITQQPRQMRQPSQGMIHELHSQGS--LRLLEDQENQHPDS--SNCSERDIR-PFNSGHPGS---EGHTEIPACLRNALHRPSRLADLADDAMESSESD------FCPPNRKASFMVRMPSES---MSGSPSCPSTRSSESELGSLNDLP-MNPPPGGGRRMSMSVF---------------------------LDISSIMKK------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "********.****** ********************* ******* **** *.*** ****.*:***:********:*********************:** :**:*:::* *:.::*:.: ***::::::***:*****:::*.**:*.*****::*******:**.*::***:***: : *:*** : ****:***:*******.***:** *:.:**:**:*** ***::** ::: :: . .: * *.: . *.: * :: : .: . * :: .:. .: :. . : : . * . . : . : * ... * *****: * **. * * :. * .: : : * *. *:* ** ", "identical_positions": 192, "similar_positions": 104, "identity": "35.23%" }, { "cls_id": "homologset.agr.HGNC:16996", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63524-1", "uniprot_id": "TMED2_RAT", "id": "Q63524-1", "name": "Transmembrane emp24 domain-containing protein 2", "aln": "-MVTLAELLVLLAALLA---TASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEG-----GFLDIDVEITGPDNKGIYKGDRES-SGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPK-----GQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0Q3-1", "uniprot_id": "TMED2_MOUSE", "id": "Q9R0Q3-1", "name": "Transmembrane emp24 domain-containing protein 2", "aln": "-MVTLAELLALLAALLA---TASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEG-----GFLDIDVEITGPDNKGIYKGDRES-SGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPK-----GQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15363-1", "uniprot_id": "TMED2_HUMAN", "id": "Q15363-1", "name": "Transmembrane emp24 domain-containing protein 2", "aln": "-MVTLAELLVLLAALLA---TVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEG-----GFLDIDVEITGPDNKGIYKGDRES-SGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPK-----GQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W4K0-1", "uniprot_id": "Q9W4K0_DROME", "id": "Q9W4K0-1", "name": "", "aln": "MESTLAKVLLLVGSLLILCRTSHAFIVSVDAHNEECFFENVEGGTKFGVTFEVIDG-----GFLDVDIKISGPDNHVMHESEKES-SGKYTFVAPAKGTYTVCFNNERSSMTPKLVMFSIDVGDAPQRAP--GAPGEEEVGHTKLEDMIRELSGTLTSVKHEQEYMHVRDKIHRSVNENTNSRVVLWSTFEALVLVLMTVGQVYYLKRFFEVKRVV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W2A6-1", "uniprot_id": "Q9W2A6_DROME", "id": "Q9W2A6-1", "name": "GOLD domain-containing protein", "aln": "----MLSAIVLVLVLFQ---AACGFIVTLDAHETMCFYDHANVSDKVTVSFEVMEG-----GFKDVGVEIAGPDDDRLHHSKQDT-MGSFTFTAMKEGRYQLCFDNKMSTMTPKILMFQFHVARAIEFYMDSSKRVDDVIEQATVQSMINQLSAKLGAVKMEQEYMHFRYRGHLEVSDMVELRVLAWSIFGPMMLIITAVLEVYYLKHFFEVKRVV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32803-1", "uniprot_id": "EMP24_YEAST", "id": "P32803-1", "name": "Endosomal protein P24B", "aln": "-MASFATKFVIACFLFF---SASAHNVLLPAYGRRCFFEDLSKGDELSISFQFGDRNPQSSSQLTGDFIIYGPERHEVLKTVRDTSHGEITLSAPYKGHFQYCFLNENTGIETKDVTFNIHGVVYVD---------LDDPNTNTLDSAVRKLSKLTREVKDEQSYIVIRERTHRNTAESTNDRVKWWSIFQLGVVIANSLFQIYYLRRFFEVTSLV", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : *: : .. * : *: **:: . :. : *:. : . .. * **: . : . ::: *. *: * .* : ** *. : : .* : * :. . .::. :.:*: ** **.*: .* : * : .: ** ** * ::: :: ::***::**** :*", "identical_positions": 39, "similar_positions": 65, "identity": "18.06%" }, { "cls_id": "homologset.agr.HGNC:16997", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5M971-1", "uniprot_id": "AF1Q_RAT", "id": "Q5M971-1", "name": "Protein AF1q", "aln": "MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDSPTYKSKESNSIGKMGGQATGAER-KSPEGDPLLEYSTFNFWRAPIASIRSIDLDLL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P97783-1", "uniprot_id": "AF1Q_MOUSE", "id": "P97783-1", "name": "Protein AF1q", "aln": "MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTPTYESKDSSSVGKMNGQASGTEQ-KNPEGDPLLEYSTFNFWRAPIASIHSVDLDLL-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13015-1", "uniprot_id": "AF1Q_HUMAN", "id": "Q13015-1", "name": "Protein AF1q", "aln": "MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDS-SVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A3KQS5-1", "uniprot_id": "AF1Q_DANRE", "id": "A3KQS5-1", "name": "Protein AF1q", "aln": "MLDKTSSQFDSFLFWRQPIPSLDLSELEDLGISAP---KSKEMKSTKSFPRQDEDEDR----E---LSKFSTFNFWKEPIPSIDTLDFSLLL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * .***:.****** ***.*******.**:* . : *: * .: * :: * * ::******: **.** :.::.** ", "identical_positions": 41, "similar_positions": 22, "identity": "44.57%" }, { "cls_id": "homologset.agr.HGNC:16998", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63584-1", "uniprot_id": "TMEDA_RAT", "id": "Q63584-1", "name": "Transmembrane emp24 domain-containing protein 10", "aln": "MSGLSGPLSWPGPLLSALLFLFLLGPSSVLGISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRTHLKITDSAGHILYAKEDAT-KGKFAFTTEDYDMFEVCFESKGTG--RIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D1D4-1", "uniprot_id": "TMEDA_MOUSE", "id": "Q9D1D4-1", "name": "Transmembrane emp24 domain-containing protein 10", "aln": "MSGLFGPLSRPGPLPSAWLFLLLLGPSSVLGISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRTHLKITDSAGHILYAKEDAT-KGKFAFTTEDYDMFEVCFESKGTG--RIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P49755-1", "uniprot_id": "TMEDA_HUMAN", "id": "P49755-1", "name": "Transmembrane emp24 domain-containing protein 10", "aln": "MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDAT-KGKFAFTTEDYDMFEVCFESKGTG--RIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8SXY6-1", "uniprot_id": "TMEDA_DROME", "id": "Q8SXY6-1", "name": "Transmembrane emp24 domain-containing protein bai", "aln": "-------MAR----AAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEFEVSDVPG----QIIDYIARDTKGHILSQKEHIT-KGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P54837-1", "uniprot_id": "TMEDA_YEAST", "id": "P54837-1", "name": "Endoplasmic reticulum vesicle protein 25", "aln": "-------MQVLQLWLTTLISLVVAVQGLHFDIAASTDPE-QVCIRDFVTEGQLVVADIHSDGSVGD--GQKLNLFVRDSVGNEYRRKRDFAGDVRVAFTAPSSTAFDVCFENQAQYRGRSLSRAIELDIESGAEARDWNKISANEKLKPIEVELRRVEEITDEIVDELTYLKNREERLRDTNESTNRRVRNFSILVIIVLSSLGVWQVNYLKNYFKTKHII-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *.: : : : *::: : . ** . . . * . *: *: *.. : . :.:* : :::** .: * : : * : *.*::.:: *. .****:**:*:*:*::::.** ::. :::***.:*****.** ** ***: : * .*..*** **:.:**:*::* ", "identical_positions": 53, "similar_positions": 70, "identity": "23.87%" }, { "cls_id": "homologset.agr.HGNC:16999", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5PQL4-1", "uniprot_id": "CLP1_RAT", "id": "Q5PQL4-1", "name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "aln": "------MSEESNDD------------KKPTTKFELERETELRFEVEAS-QSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSG---RTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGR-RPTYVELDVGQGSVSIPGTMGALYIERPADVEEG------------FSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYG-YQALVHAASAFEVDVVVVLDQER--LYNELKRDLPHFVR---TVLLPKSGGVVERSKDFRRECRDERIREYFYGFRG-CFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRD-MVHHLLSVSTAEGTEEN-----LSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIM-DIRFMDLK-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99LI9-1", "uniprot_id": "CLP1_MOUSE", "id": "Q99LI9-1", "name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "aln": "------MSEESNDD------------KKPTTKFELERETELRFEVEAS-QSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSG---RTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGR-RPTYVELDVGQGSVSIPGTMGALYIERPADVEEG------------FSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYG-YQALVHAASAFEVDVVVVLDQER--LYNELKRDLPHFVR---TVLLPKSGGVVERSKDFRRECRDERIREYFYGFRG-CFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRD-MVHHLLSVSTAEGTEEN-----LSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIM-DIRFMDLK-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92989-1", "uniprot_id": "CLP1_HUMAN", "id": "Q92989-1", "name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "aln": "------MGEEANDD------------KKPTTKFELERETELRFEVEAS-QSVQLELLTGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSVQLSG---RTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGR-RPTYVELDVGQGSVSIPGTMGALYIERPADVEEG------------FSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSG-YQALVHAASAFEVDVVVVLDQER--LYNELKRDLPHFVR---TVLLPKSGGVVERSKDFRRECRDERIREYFYGFRG-CFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRD-MVHHLLSVSTAEGTEEN-----LSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIM-DIRFMDLK-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F3I6-1", "uniprot_id": "CLP1_DANRE", "id": "E7F3I6-1", "name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "aln": "------MTAEAAEKSVEEGLSSSGSAGSSGTRFDLDKETELRFEVEAG-ERVQLELLSGLAEIFGSELNRNKKYTFGPGSKIAVFTWQGCGVALSG---KTEVAYVSKDTPMLLYLNTHAALEQMRRQAEKDNERGPRVMVVGPTDVGKSTVCRMLLNYAVRLGR-RPTLVELDVGQSSVSVPGTMSALCIERPADVEEG------------FSVQAPLVFHFGSTTPGTNIKLYNKLTSSLADAFSQRCEVNRRASVGGCIINTCGWVKGSG-YQALVHCASAFQVDVVLVLDQER--LYNELKRDLPHFVR---VVLLPKSGGVVERSKDCRRETRDEKIREYFYGFRGTSFYPHAFDVRFSDVRIYKIGAPSIPDSCLPLGMSQDDTQLKLVPVSPGRD-LTHHVLSVSSVDDEAEVGQSRGILESPACGFIVVTAVDTQAQVMTVLSPAPRPLPRHTLLIM-DIRFIDLK-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7K284-1", "uniprot_id": "CLP1_DROME", "id": "Q7K284-1", "name": "Protein CLP1 homolog", "aln": "------MSEDQGKD------------------YTLESDSELRFEIEQKDAKVLVSLVSGFAELFGTELVKKKQYEFGVGAKVAIFTYQGCVLHVSG---KMDVCYISKETPMVQYVNCHAALEQFRMEAEEKDRYGPVAMVVGPMDVGKSTLCRILLNYAVRVGR-RPLYADLDVGQGSIAISGSVATILIERPANVEEG------------FAKTAPLVYHFGHKSPSGNSVLYNAVVSKMAEVTLQSLNSNKRTKSSGIIINTCGWVKGSG-YAHLLHAAKAYGACAIFVLDQER--LYNELLRDVPKGVH---VVLLPKSGGVVERSKELRHEARDQRIKEYFYGNTRAPFYPFSFEVKFQDLRLYKIGAPPLPDSCMPIGMKAEDNKTKVVAVTPTPA-LIHHVLALSFAESVEDD-----VIGTNVAGFCCVTEVDMERQAVMLLSPQPRPLPPNALLLWSELQFMDNHT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q08685-1", "uniprot_id": "CLP1_YEAST", "id": "Q08685-1", "name": "mRNA cleavage and polyadenylation factor CLP1", "aln": "MASLPGIDEHTTSEELITG-------DNEWHKLVIPKGSDWQIDLKAE-GKLIVKVNSGIVEIFGTELAVDDEYTFQN-WKFPIYAVEETELLWKCPDLTTNTITVKPNHTMKYIYNLHFMLEKIRMSNFE----GPRVVIVGGSQTGKTSLSRTLCSYALKFNAYQPLYINLDPQQPIFTVPGCISATPISDILDAQLPTWGQSLTSGATLLHNKQPMVKNFGLERINENKDLYLECISQLGQVVGQRLHLDPQVRRSGCIVDTPSISQLDENLAELHHIIEKLNVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIPKLDGVSAVDDVYKRSLQRTSIREYFYGSLDTALSPYAIGVDYEDLTIWKPSN----------VFDNEVGRVELFPVTITPSNLQHAIIAITFAERRADQAT---VIKSPILGFALITEVNEKRRKLRVLLPVPGRLPSKAMILT-SYRYLE---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . .. : :: ::::: : :.: :*:.*:**:** ..:: * *..::: . : . :. :. : .* * * **::* . : ** .::** :.**:::.* * .**::.. :* :** * .::.* :.: *. :.: : *:* :** . * ** * :.:. * . : :. .* :::* . : * * . . :.** .* *:::: : . : .::** .** .. ::. : *:***** : *.:: * :.*: ::* . :. : : ::..*: : * ::::: .: : : : ** :* *: : : . :* * * ** : ::: . :::: ", "identical_positions": 72, "similar_positions": 156, "identity": "15.16%" }, { "cls_id": "homologset.agr.HGNC:17", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99PG0-1", "uniprot_id": "AAAD_MOUSE", "id": "Q99PG0-1", "name": "Arylacetamide deacetylase", "aln": "-MG-KTISLLISV-VLVAYYLYIPLPDAIEEPWKVVWETAFVKIGTDLASFGELLGISHFMETIQLLMSFQEVPPTSDEHVTVMETAFDSVPVRIYIPK--RKSMALRRGLFYIHGGGWCLGSAAHFSYDTLSRWTAHKLDAVVVSTDYGLAPKHHFPRQFEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAAVTQQLIQDPDVKIKLKVQALIYPALQALDTNVPSQQEGSHFPVLTRSLMVRFWSEYFTTDRGLEKAMLLNQHVPMESSHLLQFVNWSSLLPERYKKSPVYKNP----TPGSSELAQKYPGFIDVKACPLLANDNILHHLPKTYIITCQYDVLRDDGLMYVKRLQNVGVHVTHHHVEDGFHGTFSF----PGLKLSERMKNQYLSWLIKNL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9QZH8-1", "uniprot_id": "AAAD_RAT", "id": "Q9QZH8-1", "name": "Arylacetamide deacetylase", "aln": "-MG-RTIFLLISV-VLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGDLASFGELLGLNHFMDTVQLFMRFQVVPPTSDENVTVMETDFNSVPVRIYIPK--RKSTTLRRGLFFIHGGGWCLGSAAYFMYDTLSRRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVYHSLRWFLQEDILEKYGVDPRRVGVSGDSAGGNLTAAVTQQILQDPDVKIKLKVQALIYPALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTDRDLEKAMLLNQHVPVEFSHLLQFVNWSSLLPQRYKKGYFYKTP----TPGSLELAQKYPGFTDVKACPLLANDSILHHLPMTYIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGALTL----PGLKITYRMQNQYLNWLHKNL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P22760-1", "uniprot_id": "AAAD_HUMAN", "id": "P22760-1", "name": "Arylacetamide deacetylase", "aln": "-MGRKSLYLLIVG-ILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPK--RKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNP----NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSF----LGLKISHRLINQYIEWLKENL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5H8-1", "uniprot_id": "A0ACD6B5H8_DANRE", "id": "A0ACD6B5H8-1", "name": "Neutral cholesterol ester hydrolase 1", "aln": "MMRSKGVFVLVLLGALTAYHVYSPIPSDIEERWKLMVTDSFFKSLSQLAELSEQVGLLDYMRVMMFITIAERVVPVSDDRVQVAEENFDGVEVIVYQPNQLEQTGELRRAIIYLHGGGWCLGSSRMGPYDLLARHMVKELNAVIVAVEYRLAPAYHFPVQFEDVHRVVKYFLQNDVLKRYNINPERIAVSGDSAGGNLAAAVAQQLRKDPEQHIQLKAQALIYPVLQALDLKTPSYQQNQHMPILPRTLMVRFWSEYFTSDKSFLRAMMANTHNNHESAALLKFVNWSSYLPDSYRQTYNYSAPPVLTGKGPVRSIGAHHLLADPRASPLLVPDTALRFLPKAYVLTCEYDVLRDDGLMYVTRLRNAGVDVTHEHYPSGFHGALMFTVWPTDFEIGHRMTNNYITWLKQNL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : :*: * **::* *:*. :** *::: : .* :** : * :*: .:* . .. : * *.**:.* * * *:.: * :* *: .:: ***.::::******:**: ** *:* ...*:**:*:.:* *** :*** *****:. :::**::.:* :*.::*.*:.:*********:***:**: .**: :*:** *:****.**.** . ** *:..: .*.::*::********:*:.: :**: . * * : *::****** **: : : *. * *. . : : * :*.***. *. *: ** :*::**:**:*********.**:*.**.***.* .****:: : .::: *: *:*: ** :**", "identical_positions": 166, "similar_positions": 135, "identity": "40.39%" }, { "cls_id": "homologset.agr.HGNC:170", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99JY9-1", "uniprot_id": "ARP3_MOUSE", "id": "Q99JY9-1", "name": "Actin-related protein 3", "aln": "MAGR-LPACVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IKESAKVGDQAQRR----------------------------VMKGVDDLDFFIGDEAIEK---PTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4V7C7-1", "uniprot_id": "ARP3_RAT", "id": "Q4V7C7-1", "name": "Actin-related protein 3", "aln": "MAGR-LPACVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IKESAKVGDQAQRR----------------------------VMKGVDDLDFFIGDEAIEK---PTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P61158-1", "uniprot_id": "ARP3_HUMAN", "id": "P61158-1", "name": "Actin-related protein 3", "aln": "MAGR-LPACVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IKESAKVGDQAQRR----------------------------VMKGVDDLDFFIGDEAIEK---PTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P32392-1", "uniprot_id": "ARP3_DROME", "id": "P32392-1", "name": "Actin-related protein 3", "aln": "MAGR-LPACVIDVGTGYSKLGFAGNKEPQFIIPSAIA------IKESARVGDTNTRR----------------------------ITKGIEDLDFFIGDEAFDA---TGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVFGTMT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47117-1", "uniprot_id": "ARP3_YEAST", "id": "P47117-1", "name": "Actin-related protein 3", "aln": "MSYLNNPAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAAPSNTKKSSGVGAPSAVSNEASYFGNSTSATNFNGATGGLLSNNLSGKRGTEDLDFYIGNEALVASQGPSYSLSYPIRHGQVENWDHMERFWENSIFKYLRTEPEDHFFLLTEPPLNPPENREQVAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSAIKNIPIAGRDITLFIQSLLRERGE---ADTSLRTAEKIKQEYCYVCPDIVKEFNKFDKDPSKFA-QFVVENQEKTRRKVVDIGYERFLAPEIFFNPEIASSDFLTPLPTVVDQTIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDLKSIVNNRIAQSELLSG--TKSTGVDVSVISHRKQRNAVWFGGSLLAQTAEFKGYCHTKKDYEEYGPEIVRNFSLFNMV-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: ** *:* *** :***:*** .*.:::*:.** *:*: ** :* :****:**:**: . *: .:*:*** **:** **** *: :*****:*****:*********.***** .***:**:** .****************:* .. :*:*** *:********************.**:******:** ***.***:* .: **.**: :*:.:.*:***:.*** *:*.: .*: :: * .. :*:******.*****:**::..** *:. :**:.** ******: **:***********:*********:* *: *: ** ** *.. :**.**:*: ** *******:**.*.** **** *** **.* *: .:*. : ", "identical_positions": 239, "similar_positions": 99, "identity": "52.41%" }, { "cls_id": "homologset.agr.HGNC:1700", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q00609-1", "uniprot_id": "CD80_MOUSE", "id": "Q00609-1", "name": "T-lymphocyte activation antigen CD80", "aln": "MACNCQLMQDTPLLKFPCPRLILLFVLLIR-LSQVSSDVDEQLSKSVKDKVLLPCRYNSPHEDESEDRIYWQKHDKVVLSVIAGKLKVWPEYKNRTLYDNTT-YSLIILGLVLSDRGTYSCVVQKKERGTYEVKHLALVKLSIKADFSTPNITESGNPSADTKRITCFASGGFPKPRFSWLENGRELPGINTTISQDPESELYTISSQLDFNTTRNHTIKCLIKYGDAHVSEDFTWEKPPEDPPDSKNTLVLFGAG-------------FGAVITVVVIVVIIKCF-CKHRSCFRR-NEASRETNNSLTFGPEEALAEQTVFL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V671-1", "uniprot_id": "G3V671_RAT", "id": "G3V671-1", "name": "T-lymphocyte activation antigen CD80", "aln": "MAYSCQLMQESPLLGFPRLRFIHLFVLLLVGLFQISSGIVGQVSKSVREKALLSCDYKFCSEEQSIHRIYWQKHDKMVLSVISGVPEVWPEYKNRTVYDIANNYSFSLLGLILSDRGTYTCVVQRYEGGSYVVKHLTTVELSVRADFPTPNITESGNPSADIKRITCFASGGFPKPRLSWLENGRELNGINTTISQDPESELYTISSQLDFNTTYDHFIDCFIEYGDAHVSQNFTWEKPPEDPPDEKQTIPFAWAGSDAVKAIIIFFIAITVIAVIAAIAIIIFCITVKFRRCFRRRNEASRETNKNLYIGPVEAAAEQTV--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P33681-1", "uniprot_id": "CD80_HUMAN", "id": "P33681-1", "name": "T-lymphocyte activation antigen CD80", "aln": "MGHTRR--QGTSPSKCPYLNFFQL--LVLAGLSHFCSGVI-HVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAIT--------------LISVNGIFVICCLTYCFAPRCRE--RRRNERLRRE----SVRPV----------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. . : * :. * .:: * *:: * :..*.: :::*.*:: . *.* :: *: : ******..*:**::::* ::********::* :. *: :*.* **.*** *** : * .:: :**: * **::***.**.*:: *::: :** * :*****:*::******.** .****:*****:***::**:**** * :* : *:*:**. :*.: *.*:.. :: .: : : : : .* : *: : * ** ** *. . * ", "identical_positions": 108, "similar_positions": 97, "identity": "33.44%" }, { "cls_id": "homologset.agr.HGNC:17001", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P48060-1", "uniprot_id": "GLIP1_HUMAN", "id": "P48060-1", "name": "Glioma pathogenesis-related protein 1", "aln": "----MRVTLATIAWMVSFVSNYSHTANILPDIENED---FIKDCVRIHNKFRSEVKPTASDMLYMT--------WDPALAQIAKAWASNCQFSHNTRLKPPHKLHPNFTSLGENIWTGS-VPIFS--VSSAITNWYDEIQDYDFKTRIC--KKVCGHYTQVVWADSYKVGCAVQFCPKVSGFDALS--NGAHFICNYGPGGNYP-TWPYKRGAT----------------CSACPNNDKCLDNLCVNRQRDQVKRYYSVVYPGWP---IYPRNRYTSLFLIVNSVILILSVIITILVQHKYPNLVLLD------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9CWG1-1", "uniprot_id": "GLIP1_MOUSE", "id": "Q9CWG1-1", "name": "Glioma pathogenesis-related protein 1", "aln": "----MQVILAVIVWMASSVSSSSFTASTLPDITNED---FIKECVQVHNQLRSKVSPPARNMLYMS--------WDPKLAQIAKAWTKSCEFKHNPQLHS--RIHPNFTALGENIWLGS-LSIFS--VSSAISAWYEEIKHYDFSTRKC--RHVCGHYTQVVWADSYKLGCAVQLCP-----------NGANFICDYGPAGNYP-TWPYKQGAT----------------CSDCPKDDKCLNSLCINPRRDQVSRYYSVDYPDWP---IYLRNRYTSLFLIAKSVLLLLSVIITIWVKHKYPNLVLLD------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M6YY67-1", "uniprot_id": "A0A8M6YY67_DANRE", "id": "A0A8M6YY67-1", "name": "", "aln": "----MSSCFQLLISACFLLG--VFSSEYLFDITDRA---FIDECVREHNQNRSSVSPTAANMRYMT--------WDAALAVTARAWARFCLFKHNIHLREAKRVHPTFTTVGENIWAGAPYSRFT--VKSAVFSWVNELKDYNYNNNQCNDKKVCGHYTQVVWADSYKVGCAVQTCPNGVAETHFSNIQGVIFVCNYATAGNFAGRSPYKQGAS----------------CSGCGGSDKCERNLCRNTDRDAEQSYNWTPDWDPA---LSSCGTFCVSVMIIRLISVVLLFVCVHFLQCRYSPFIYD-------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B5H0-1", "uniprot_id": "A0A8M2B5H0_DANRE", "id": "A0A8M2B5H0-1", "name": "", "aln": "----MDSLGGLLLRISVVLYGSCSVLALLPGITEPE---FIRRCVKAHNTHRARVSPPAAGARSMVRQVFGMQSWDKELAKGARDRARHCKGSHYPSLGH--FGHPLFGWMGENIWLGSPFSAFS--VENAVHRWSKEG-AYSVKNNNCS--RLCGHYAQLMWSTSFKMGCAVNVCSKGIENFSTHP-ESTIFVCNYGDTGQVHGVTPYMAMG-----------------CSGCG-SEICRDNVCR---------YDWFPGWDYG---PPSSAHSVSYWQTN----LGLCLLGVCWLLHFYATH----------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VFY2-1", "uniprot_id": "Q9VFY2_DROME", "id": "Q9VFY2-1", "name": "SCP domain-containing protein", "aln": "MMQPSAVLLTTIMIISCEVAFACNGKIIASGITAEERSIILQEHNRLRQIVATGRYPGQPGAENMR-----EIVWDDELAARAQKWADNCQFRHDPHRTIN---RFTMGQNLAIIWSTAPLDADDGDFPSRIQSWFNEVQKYSFGDAWSP---KTGHYSQLVWGETSLVGCGYAEYKDTSKYN-------KLYVCNYGPGGNVVGYNPYEVGKPSCSTYGMKPSSRYQGLCAAPGSSPAANSVYGANTIETYEYGYNSSPSSQTANNNPPTNNINKSQFSYNQPRPKPVQTINPNPSPFNPQAAVPSASTFGGSSFGSASRGGSHAYTTDPSQSAGRYKHKLEAYRPSAAEFEKSVHKHTILRTYIEQNQQRQDQQQQQQQKEQDQQQQQPEPSSTKKPSRGWSLLTWRG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .* :: : :: : * . * ** ** *: : * * : : ** : . . : * .* *. . ***:*::*. : :**. ::*:*. *: ** *: . . * : : ", "identical_positions": 29, "similar_positions": 38, "identity": "7.07%" }, { "cls_id": "homologset.agr.HGNC:17002", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JM05-1", "uniprot_id": "PIAS4_MOUSE", "id": "Q9JM05-1", "name": "E3 SUMO-protein ligase PIAS4", "aln": "-------------------------------------MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFK----KIKELYETRYAKKSAEPGPQAPRPLDP-----LALHS-------MPRTPLSGPTVDYPVLYGKYLNGLGRLPTKTLKPEVRLVKLPFFN------MLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGV---KAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSS-ATNRITVTWG-NYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSEC---EGADEIEFLAEGSWR---------------------------------------------------------------------------PIRAEKEP-------------SCSPQGPILVLGTSDANGLAPASSTPGIGSGLSGP---------------GSAGSGAGAAGSLENGKTGADVVDLTLD--------------------------------------SSSSSEDEDEDEDDDEDEDE--GPRPKR-RCPFQKGLVPAC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B5DFF9-1", "uniprot_id": "B5DFF9_RAT", "id": "B5DFF9-1", "name": "E3 SUMO-protein ligase PIAS4", "aln": "-------------------------------------MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFK----KIKELYETRYAKKSAEPGPQAPRPLDP-----LALHS-------MPRTPLSGPTVDYPVLYGKYLNGLGRLPTKALKPEVRLVKLPFFN------MLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGV---KAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSS-ATNRITVTWG-NYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSEC---EDADEIEFLAEGSWR---------------------------------------------------------------------------PIRAEKEP-------------SCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGP---------------GGAGGGAGAAGGLENGKTGADVVDLTLD--------------------------------------SSSSSEDEDEDEDDDEDDDE--GPRPKR-RCPFQKGLVPAC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N2W9-1", "uniprot_id": "PIAS4_HUMAN", "id": "Q8N2W9-1", "name": "E3 SUMO-protein ligase PIAS4", "aln": "-------------------------------------MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFK----KIKELYETRYAKKNSEPAPQPHRPLDP-----LTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFN------MLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSRELQPGV---KAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSS-ATNRITVTWG-NYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSEC---EDADEIEYLVDGSWC---------------------------------------------------------------------------PIRAEKER-------------SCSPQGAILVLGPSDANGLLPAPSVN--GSGALG------------------STGGGGPVGSMENGKPGADVVDLTLD--------------------------------------SSSSSEDEEEEEEEEEDEDEE-GPRPKR-RCPFQKGLVPAC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R4C4-1", "uniprot_id": "PIS4A_DANRE", "id": "F1R4C4-1", "name": "E3 SUMO-protein ligase PIAS4-A", "aln": "-------------------------------------MAAELVEAMNMVKSFRVSDLQTLLASMGRSKSGLKQDLVGRALRLVQTEYSPELLK----NVRQLYETRFPKASAWLAARRPETVAVNY---PALNS-------SPRGTGQG---------TDYLNGIP-KPAPPPAAEVKLVPLPFYH------NLETLLPPTELVAQNSEKLQESQCVFDLTPNQVDQIRNSSELRPGM---KSVQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEPRRPCRPVNITPWLHLST-VTNRVTITWG-NFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQDKLRFDPESEIATTGLRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQMNEKKPTWTCPVCDKPAPFELLTIDGLLSEILKETP--EDVEEIEYLTDGSWR---------------------------------------------------------------------------PIRDDKEKERE-------RENSRTPDYPVVDICVPEANGHSPAHSGTN-QTGKSG------------------SGGASAGTGSTSGGSGGGTVVDLTLD--------------------------------------DSSEEEGGGGAEDSEETDDSQDSPAPKRGRYDYDKDLVTAY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F8W4B9-1", "uniprot_id": "F8W4B9_DANRE", "id": "F8W4B9-1", "name": "", "aln": "-------MISVVVEGLSLGLYFFSVYFTLIVLFIFEIMSTDVLEAAVMLETLRVTELRLLLSKMGKSKSGLKKDLQKRVTDLLHNDCSPELLS----AVRELHDLRQISKSRRSG--------------IEIIS-------MPESLSPG------------------GTPSPKSAGPQMIKLPFYQ------MLETIIPPTPLVPTYGGAMQNSDFLFHLSESQQALIQNSRSSQP-------VQVVLRICYSESIGVEEDQYPPNICVSVNHNNCPVQCTYSSNKLGLEPSRPCRPIDITSDLYLS--FTNRFTVLWG-NFGKSYSVAVYLVRLVSCQQLLDQLRSSSVEQQDVCRLRVSEKLRSDPETEVATTGLQVSLICPLVKLRMSVPCRSRGCAHLQCFDASFYLQMNEKKPRWSCPVCHRYAPFDELRIDSLLRDVLESSG--EDVEEIKYLSDSTWK---------------------------------------------------------------------------AVKHDKSN---------------QNKGSALHPVKHNVNSKPVRDAVVDLTQSSSD-----------------------------DEDFQKEETVSTHIE--------------------------------------DKSVHFRKSGIVKSARHKGRKTQVHTEKHRNGN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z7P5-1", "uniprot_id": "A1Z7P5_DROME", "id": "A1Z7P5-1", "name": "", "aln": "MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTN-LELLAP----KVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYD------VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTP---------------------------------------SKPAQKVEVISDDIELISDDAKPVKRDLSPAQD-------EQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVAS---------------STSNGSGGGQRAYTPAQQPQQSESPEQQ--------------------------------------ASRQSPEKQTVSEQQLQQQQHEQPATAAVHASLLESLAAAVADQKHFQLLDLAAVAAAAAATASSGQSQNAGP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12216-1", "uniprot_id": "SIZ2_YEAST", "id": "Q12216-1", "name": "E3 SUMO-protein ligase SIZ2", "aln": "------MASVMSNNNNNNNNNNASYMFTNPLSNTGGGLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTG------------------------AFKHPVASGQLPVTALQSTALPPYSQQQALAYS---------FTSPFYKPIVQIPDANKKLKQS-AGRGCTKMKFKVSKSNHDLLKS---NKSYKLYLFSGFSIPFIYETVGHEAIDFPYPCELVFNGTKLEDNVKGLKKQNGTGNPANLTPYLKVPT-EMNHLDLHYL-NIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQNCN--EDVEQVEISVDGSWKPIHN--------------------------------------------------SSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKS-FPTHVNPR----------NDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNY----------------------QDAFQMRSFLNQGATTNINDTPTNNSS--INSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQ--------RNPYGPNYNTTAQDRNLLG---------------------------------------------------IEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSG--------HGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFN---TSAQDNSEVVDLTSD", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q04195-1", "uniprot_id": "SIZ1_YEAST", "id": "Q04195-1", "name": "E3 SUMO-protein ligase SIZ1", "aln": "----------MINLEDYWEDETP-----GPDREPTNELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVT-GGRGMCSAKFKLSKADYNLLSNP--NSKHRLYLFSGMINPLGSR--GNEPIQFPFPNELRCNNVQIKDNIRGFKSKPGTAKPADLTPHLKPYT-QQNNVELIYA-FTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNCQ--KNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : ::* :*: : :. . :* * * ::: :. . . . : :. :: : . . :: * . . . . . : . . .* ::* : * . : : : * : ::*. .: *: :: : :. .* : : : ** :** **: :: *.: * *:***** :*: : : * * **:*. : * *. . .:: . .. ::: :..* .:: : . . . : . : .. : ", "identical_positions": 36, "similar_positions": 103, "identity": "3.88%" }, { "cls_id": "homologset.agr.HGNC:17003", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A974-1", "uniprot_id": "A0A8I6A974_RAT", "id": "A0A8I6A974-1", "name": "Stonin-1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MCSTNPGSWVTFDDDSLFQSSPKK-----KDLSLETQGVCRPNGLKLDLPG-------------------------------LRDLPNTPSSTGSTPLSSP--------------------------------------------------MVDFYFSPGPPSNSPLSTP----------------------------------TKDFPGFPGIPKAGTHVLYPIPECSS-----SGPPTTAGGAGPPLSLTKP--TCSPHVSLPSGHSHTQLTPTAGLTEDASPR-------GVQS-EARQFEYFQDDCAFSN------------------------------PFWKDEGGNSQFPFDSLASRKLFSPRDKE---------------VPDDQKSLNQCSLNYICEKLEHLQSAE----------------TQDPLGNLSMQSSYAGGTFS--------------------------------------------FVPHTLFRSQPKA----------------------------------------------------------------------GWSFMLRIPEKKNMMSSRQWGPIFLKVLPG---GILQMYYEKGLEKPFKEFQLNPHCRLSEPKLENFSMAGKIHTVKVEHVSYSEKRKYHS--------------------------------------KVEVVHEPEVEQMLKLGSTEHRDFLEFLTTVEEELVKLPATAKPKNKIYEEQEIHLDILDSFWGKVTKEEGKLVESAVLTQVCCLCFLNGPAECFLALNDLELQKRDER---YFEKEPEKRGIDILNYHFHTCVNAEEFERSRIIKFVPPDACRFELMRFRTSS-EGDELPFSVKSIVTVQGAYVELQAFVNMTPAVQRSPHAGSLRSCNNIMIHFPVPAQWIKALWTRNLQRQKSLKAKMNRRACLGSLQ------GPELEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNTSPDQPHCLSYKLELGSDQEVPSDWDPFATVQFSMSEACASRTEVRSLGVES---DAQPQKHVCQRACYNIQVEIEKKWIQID----------GEDPDKAGGCVTQ-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CDJ8-1", "uniprot_id": "STON1_MOUSE", "id": "Q8CDJ8-1", "name": "Stonin-1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MYSTNPGSWVTFDDDPAFQSSQKR-----KDFSLETQGVCRPNGLKLTLPT-------------------------------LRDPPSTPSSASSTPLSSP--------------------------------------------------MVDFYFSPGPPSNSPLSTP----------------------------------TKDFPGFPGIPKAGTHVLYPIPECSS-----SSAPTTAGGVGPPLLLTKP--DCSPHVSLPSSHSHTQPTPTLGFTEDAGPQ-------RVQS-EARQFEYFQDHCAFSN------------------------------PFWKDEGSASPFPLDSLASRKPFSPKDKE---------------VPIGHKSLTQCSLDYICEKLEHLHSAE----------------TQDPLGDLSMQDPYAGDTVS--------------------------------------------FVPHSLFRSQPRA----------------------------------------------------------------------GWSFMLRIPEKKNMMSSRQWGPIFLKVLPG---GILQMYYEKGLEKPFKEFQLDPHCRLSEPKLENFSMAGKIHTVKVEHVSYSEKRKYHA--------------------------------------KTEVVHEPEVEQMLKLGSTEHRDFLEFLTTVEEELIKLPATAKPKNKSYEEQEICLDIQDSLWGKVTKE-GQLVESAVVTQICCLCFLNGPAECFLALNDRELQKRDEC---YFEKEPEKKGIAILDYHFHTCVKAEEFEQSRIIKFVPLDACRFELMRFKTSY-EAGELPFAVKSVVTVQGAYVELQAFVNMTPAAQGSPHAGALRSCNNIMIHFPVPAQWIKALWTRNLQRQKSLKAKMNRRACLGSLQ------EPESEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNSSPDQPHCLSYKLELGSDQEVPSDWYPFATVQFSMLEACASRTEVRSLGVES---DAQPQKHVCQRACYNIQVEIEKKWIQVD----------GEDADKTGGCVTQ-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y6Q2-1", "uniprot_id": "STON1_HUMAN", "id": "Q9Y6Q2-1", "name": "Stonin-1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------MCSTNPGKWVTFDDDPAVQSSQKS-----KNFPLENQGVCRPNGLKLNLPG-------------------------------LREFPSGSSSTSSTPLSSP--------------------------------------------------IVDFYFSPGPPSNSPLSTP----------------------------------TKDFPGFPGIPKAGTHVLYPIPESSS-----DSPLAISGGE-SSLLPTRP--TCLSHALLPSDHSCTHPTPKVGLPDEVNPQQA--ESLGFQSDDLPQFQYFREDCAFSS------------------------------PFWKDEGSDSHFTLDPPGSKKMFSSRNKE---------------MPIDQKSLNKCSLNYICEKLEHLQSAE----------------NQDSLRSLSMHCLCAEENASS-------------------------------------------FVPHTLFRSQPKS----------------------------------------------------------------------GWSFMLRIPEKKNMMSSRQWGPIFLKVLPG---GILQMYYEQGLEKPFKEIQLDPYCRLSEPKVENFSVAGKIHTVKIEHVSYTEKRKYHS--------------------------------------KTEVVHEPDIEQMLKLGSTSYHDFLDFLTTVEEELMKLPAVSKPK-KNYEEQEISLEIVDNFWGKVTKE-GKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDES---YYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLY-NGDNLPFSLKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQRQKSLKAKMNRRACLGSLQ------ELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGVES---DVQPQKHVQQRACYNIQVEIEKKWIKID----------GEDPDKIGDCITQ-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24212-1", "uniprot_id": "STNB_DROME", "id": "Q24212-1", "name": "Protein stoned-B", "aln": "MANPFLMDEDLDGCDAAANPFLMQSEPEPSSDNPFMAATVASNPFAFGADDLELGAEPEAEATHDNDLDPAMSFFGTTIEAEDDTLSLKSGAEEEDEGKKPPQSQPQLQSHAHPHPPPPRPLVPPQSTQDLISTVSSQLDETSSELLGRIPATRSPSPVSMRDLHSPSPTPDSGLADLLDVSVDSGSSAHTQGIEADLISGVAGGVRLDNPFAVPTAVPNIQAAVPLPATPIKQPPRPPPPRPAPPRPAPPGQAAPQRPPPPLAAVNPPPAAPEADDLLDMFGTTACKPAKPPPPKSKEDILSLFEQPHVPLSQPASKPDLLHDDLDETIGEGEPPEQEEPDTEQSNEISSRDEPVFTSLLIRPDESTHDITSQPQAATGLERQVNNMAAPSGTASTQRATTPDIEITTVEDLPRSDDEDEPEAMQEPETETKPQIEPDTEPEIVSEHSPPTERLVTQAALVDGELIAAEPEPEEMDTGLDFPLASSGQLSANPFASPDEEEPNFAPMPAAVANIFAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSVKKDNISIMDGFGGSGAITPTGGDAWGGSAFGSTTISANACGDTNSADDGFGNDDDDFYAMQAPARADSVESVDKDFSVVIRPMAEETSGVAPQLAPPPPPARGVNQAQTTSLPGLTVNPFEDVSGFPAPGLPPTDGTAIKRTDSQDTPQTPLYDEDVSQPLEEFPRLHYIGPGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKEFGSDLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPAL-RERALTYKMEEVQVTAVDEITVEQDFE-GKILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLKATWCVSGNKVELRADILVPGFTSR---KLGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCRMALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLARHEYKVGIETTHGESTNAYLAATRPIREEPPTTATKPTASPVAPSDSDTDSN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :*.. . *:: * ..: . :..::. . .:.:*:: * ::: * ... :.* .:* ::.:: .* * ..* *.* *..: *. .** : . *:.:: . : ..* .. * * . ** ... . . :. *: . * . : : ..*: . ** . : . *. . . : *: .: : .. . ..: * .: . * ::: : ..: . :: . . * ..*: . * **.: ** *:**:: ..* * *.:::: ::*: : * ::**:*: *:* :** :::. ***.*:*:::: *.*: :. * * *: .*::*:** .:.*: :* . :** *.*:** : : *: :*: : *.: : * *::::. . .:: *.*:.* * :** :: . :. * : .**. *: :*:*::* *** * ** :**:**:. : :**: :*: *.* ***:* : :. .. . .*::: ::**:* ** : . : * *:*: .* . : .:: *.:*:** *.**** ::*:**: ***.:. . .* * :: * * :::**: *:* *:*:: : .*:* ***:.*:. * *:*:* * :: :* **.. : *:. . . * ", "identical_positions": 164, "similar_positions": 275, "identity": "12.94%" }, { "cls_id": "homologset.agr.HGNC:17004", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7FIK1-1", "uniprot_id": "F7FIK1_RAT", "id": "F7FIK1-1", "name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "aln": "MSSLTEEIASSSSSYPQCLEQFLVHKFQFWALQTCFSYYSICHNQGEFWDMATASPRSDTS-DNHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEIK-KTAKSSSSSNPKWDEQLIVN-VAPQTTLEFRVWSHHTLKAD--ALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLENK--NGIVQTGELTVVLDGLVIEPEAVTNRSSSPPIEIQQNGDAVHENGDPLTRTTPRLAVEGTIGIDNHVSTSTVVPSSCCSHIVNGENTPSSPPQVATRPQNTPAPKPLTSEPTSDTVNGESSS-VLADSTSAMGTSLPSEDSTSTSNCTSTTVQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPD-SDSRNNSGFD--KVRQPEGCVEPLRPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----------------LPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKG--GPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BZZ3-1", "uniprot_id": "WWP1_MOUSE", "id": "Q8BZZ3-1", "name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "aln": "--------------------------------------------------MATASPRSDTS-DIHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEVK-KTAKSSSSSNPKWDEQLIVN-VTPQTTLEFRVWSHHTLKAD--ALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLENK--NGIVQTGELTVVLDGLVIEQEPVTNRSSSPPIEIQQNGDALHENGDPATRTTPRLPVEGTIGIDNHVSTNTVVPNSCCSHVVNGENTPSSPSQVAARPKNAPAPKPVTSAPTSDTVNGESSS-VLADNTSTMGTLLPSEDTTSTSNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPD-SDSRNNSVFD--KVRQPEGCVEPLRPQSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----------------LPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKG--GPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H0M0-1", "uniprot_id": "WWP1_HUMAN", "id": "Q9H0M0-1", "name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "aln": "--------------------------------------------------MATASPRSDTS-NNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEIT-KTAKSSSSSNPKWDEQLTVN-VTPQTTLEFQVWSHRTLKAD--ALLGKATIDLKQALLIHNRKLERVKEQLKLSLENK--NGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----------------LQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKG--GPQIAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9Y0H4-1", "uniprot_id": "SUDX_DROME", "id": "Q9Y0H4-1", "name": "E3 ubiquitin-protein ligase Su(dx)", "aln": "--------------------MADGNGLPAGAASGGMEAGQTVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLR-NNGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVL-ITPNSTLHFKVLDHSSFRKD--AMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQ----IQPVAGQQNGNPPVQAVNPSVVSDA--AAGRSCMIYGGVRARMRLRSSSGN--SNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAP-----ALARPLTQVYGALPEN---TQPAAVYLPAGGGAAVGPP---GVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQR---AHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQE------------VSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39940-1", "uniprot_id": "RSP5_YEAST", "id": "P39940-1", "name": "E3 ubiquitin-protein ligase RSP5", "aln": "--------------------------------------------------MPSSIS---------------VKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDINENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITR---DLKKSNDGMAVSGRLIVVLSKLP---SSSPHSQAPSGHTASSSTNTSSTTRT-----------------------------NGHSTSSTRNHSTSHPSRGTAQAVESTLQS--------------GTTAATNTATTSHRSTNST---------------------------------------------------------------SSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGGGSN-----IPPVNGAAAAA----------FAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPR-LPSSLDQN----VPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGV-LDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:: . : .* .. : . :. : :*. . .* ..: * *:* : . : :: * ::* .: .:: . .:** : : . * : . .: ::.: .: . * : . : . .*.. . :. : . ** .* *. : . . .. :. . :. : .: : **.*** * * .** ********:* *::* . * : . .. :: * * . : : . : * : . * ** ***::. . .*.***:*:.:** * *** * : : *** ***:* * . :******: **:.*** .. :. *:*.** *: ** . **.: :*.* *:.:***::::** . :*::** : * *********::**:*******::**:******: :** :**** * :**:**.** ****.:.:.::* :*: : * .:** ** **:.::*:* :*.*.**** *: :*.*: *:: **.* * :*:: :** .* : **: **.**: * *:**: :::* *:*::****::* : : ***:***::: *: ::*: **:::* ** * ...: : ***: * * *** * *****.***.*:*:.** :* **:**::* ***.*: **:*******:*** * .*:.: :** :*:*** ** **", "identical_positions": 258, "similar_positions": 236, "identity": "25.62%" }, { "cls_id": "homologset.agr.HGNC:17005", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O70367-1", "uniprot_id": "CNMD_RAT", "id": "O70367-1", "name": "Leukocyte cell-derived chemotaxin 1", "aln": "MTENSDKVPITMVGPEDVEFCSPPAYATVTVKPSGSPTRLLKVGAVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYTMSINGRLQDASMEIDAANNLETFKMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVSTGTKQSIS-ELEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKILEFCGDLPIFWLKPMYPKEIPRERREVVRSSAPSTTRRPHSEPRGNAGPGRLSNRTRPSVQDDEEPFNPDNPYHQQEGE--SMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z1F6-1", "uniprot_id": "CNMD_MOUSE", "id": "Q9Z1F6-1", "name": "Leukocyte cell-derived chemotaxin 1", "aln": "MTENSDKVPITMVGPEDVEFCSPPAYTTVTVKPSGSPTRLLKVGAVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYSMSINGKLQDGSMEIDAVNNLETFKMGSGAEEAIEVNDFKNGITGIRFAGGEKCYIKAQVKARIPEVGTVTKQSIS-ELEGKIMPANYEENSLIWVAVDQPVKDSSFLSSKILELCGDLPIFWLKPMYPKEIQRERREVVRNSAPSTTRRPHSEPRGNAGPGRLSNGTRPNVQDDAEPFNPDNPYHQQEGE--SMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75829-1", "uniprot_id": "CNMD_HUMAN", "id": "O75829-1", "name": "Leukocyte cell-derived chemotaxin 1", "aln": "MTENSDKVPIALVGPDDVEFCSPPAYATLTVKPS-SPARLLKVGAVVLISGAVLLLFGAIGAFYFWKGSDSHIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAIAVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGAVTKQSISSKLEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERREVVRKIVPTTTKRPHSGPRSNPGAGRLNNETRPSVQEDSQAFNPDNPYHQQEGE--SMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVIMPCSWWVARILGMV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P58239-1", "uniprot_id": "CNMD_DANRE", "id": "P58239-1", "name": "Leukocyte cell-derived chemotaxin 1", "aln": "MEETAEKTPVEAYS---------------TLKPK-GLMKMKKTALVAFIAGAALLLFGGVGAFYLWKVTEKEAISAHLGRNIDIKIENDS--------------DSAEGTIVEVQDFKAGITAVKFPGKEKCFIKSQARTELSEDEAGVKAEVA---------------SLVWITSEEPLKDSSFLSPEILRFCADLPIYWHHPANSRALRK------RRSATRMRRQTSAGVNRQPARRRNSTASARDERPTGPEYNPENPYHQNQGSEGTMVFDPMLDHRGICCTECHRSYTHCERVCEPLGGYWPWPYNYHGCRPVCRLIMPCRWWAARVLGLV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *.::*.*: . *:**. . :: *.. *.:*:**.*****.:****:** .:.. ..* .*: :::: * .*. : *:**: ***.::*.* ***:**:*.::.:.* : .* .:: **:*:: ::*:**.****.::*.:*.****:* :* .: : : * .. ::. : . :.. * .. : . : :**:*****::*. :*.*** ***.**** **:******:::*******:******:***..**::*** **.**:**:*", "identical_positions": 118, "similar_positions": 109, "identity": "35.01%" }, { "cls_id": "homologset.agr.HGNC:17007", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A1EC97-1", "uniprot_id": "A1EC97_RAT", "id": "A1EC97-1", "name": "", "aln": "------------MSSRG-----------------HSTLPRTLMAP----RMISEGD--IGGIAQITSSLFLGRASVASNRHLLQARGITCVVNATIEIPNFNWPQFE---YVKVPLADIPH------APIRLYFDTVADKIHSVSKKHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLIDYESQLFGKSSVKMVQTP--YGIIPDVYEKESRHLMPYWGI--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ABK0LD64-1", "uniprot_id": "A0ABK0LD64_RAT", "id": "A0ABK0LD64-1", "name": "", "aln": "------------MSSRG-----------------HSTLPRTLMAP----RMISEGD--IGGIAQITSSLFLVRASVASNRHLLQARGITCVVNATIEIPNFNWPQFE---YVKVPLADIPH------APIRLYFDTVADKIHSVSKKHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLIDYESQLFGKSSVKMVQTP--YGIIPDVYEKESRHLMPYWGI--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JLY7-1", "uniprot_id": "DUS14_MOUSE", "id": "Q9JLY7-1", "name": "Dual specificity protein phosphatase 14", "aln": "------------MSSRG-----------------HSTLPRTLMAP----RMISEGD--IGGIAQITSSLFLGRASVASNWHLLQARGITCVINATIEIPNFNWPQFE---YVKVPLADIPH------APIRLYFDTVADKIHSVSKKHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLIDYESQLFGKSSVKMVQTP--YGIIPDVYEKESRHLMPYWGI--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95147-1", "uniprot_id": "DUS14_HUMAN", "id": "O95147-1", "name": "Dual specificity protein phosphatase 14", "aln": "------------MSSRG-----------------HSTLPRTLMAP----RMISEGD--IGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFE---YVKVPLADMPH------APIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTP--YGIVPDVYEKESRHLMPYWGI--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T8A1-1", "uniprot_id": "A0AB32T8A1_DANRE", "id": "A0AB32T8A1-1", "name": "", "aln": "------------MGSRSQGFFHHQDHHHQHHNHHHHHHHRSSVVPTTIPRLLPEATSLLGGIAQITPSLFLGRGNVASNRSLLLSKGITCVVNATIELPNFNWPHME---YVKVPLADMPH------SPISLYFDSVADKIHSVGRKRGAVLVHCAAGVSRSASLCLAYLMKYHRVSLAEAHAWVKARRPVIRPNGGFWRQLIEYERKLFGRNSVKMIQTP--YGVIPDVYERDRRNLAPYWGL--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VAB0-1", "uniprot_id": "Q9VAB0_DROME", "id": "Q9VAB0-1", "name": "Protein-tyrosine-phosphatase", "aln": "----MQELIVGGIAISG-------------VPFANETVEKESRQNQLSASTLEDHTP-FPGLSRITPSLILC-GAAAVVPAYMDKLGVSCVINVAPELPDTPLPSQKNPLYLRIMAQDRSE------VDLAKHFDEAADLIEEVHLSGGCTLIHCVAGVSRSASLCLAYLMKHAGMSLREAYKHVQAIRPQVRPNSGFFQQLRRYEQQLRGSSSVAMVYFASLDKEIPDILEPEYRAMEDFYQRYRSSLKRR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40479-1", "uniprot_id": "SDP1_YEAST", "id": "P40479-1", "name": "Dual-specificity protein phosphatase SDP1", "aln": "MNIYTSPTRTPNIAPKS---------------GQRPSLPMLATDERSTDKESPNEDREFVPCSSLDVRRIYPKGPLLVLPEKIYLYSEPTVKELLPFDVVINVAEEANDLRMQVPAVEYHHYRWEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKTNVQANSYR----KVP------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. . . : : : : : . : . . : : . ::: : . : : :. *. . . *:** .*:****:* :**:**. :.* .:: ::: :.*. *: ** :* * . ..* :* ", "identical_positions": 23, "similar_positions": 52, "identity": "9.13%" }, { "cls_id": "homologset.agr.HGNC:17008", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GM39-1", "uniprot_id": "A0A8I6GM39_RAT", "id": "A0A8I6GM39-1", "name": "DNA topoisomerase 2-binding protein 1", "aln": "MTPLPPEEALRPLVWRESRFLVLALPGTAALTSGWGRRRGRGLRAGLAPDPSRRPAGRAPPDLVPVGPRAPPSSAMSRNDQEPFFVKFLKSS-------DNSECFFKALESIKELQSEEYLQVITDEEALRIKEN----DKSLYICDRFSGTAFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDITISCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPAWIKTLWEKS--QEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPK--GQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAEPRAAVKT-----VPDTSTPTAQSGSAAAENHRLADVS------------HISNINGSCVNETMFGSTTSKLECTLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIMGDYEDDVRQFWSKS--SHRPHVVGAKWLLECFSKGYILPEESYIHANYQPDGIPVSDQPRN-----------QTTVLEK-SGTFSKKDFVPNEKFQQTDEDLLAQYVHDDSTIVEAKLSEAIEPEVGPCGGSAHVEPCDDSTHISVQEENKSSVSHCLLDGSTVPEEGLFSQKSFLVLGFSVENECNIVNIIREHAGKIVSLPSRIVADYAVVPLLGCEVEATVA-------EVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGMTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKSNAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARMGKRADENHFLVDSAPKQEQVLETNIPNGVSPNPDSPAHPDAH----LEIHRQKAVTPLDMNRFQSKAFHAVISQHNRQGLASPPVRQP--------PKKEPSFHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQ-KRKLSSPLSEVIVRNLTTALANSSR----NTGCLSASPQLKGAHLE--KEETPKPLDKVVVCVSKRLSKKQSELNGVAASLGAEYRWSFDETVTHYIYQGRANDSNREYKSAKERGVHVVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDISTVQDGRLCD---SRLPSALSASKDDEPDHLSVEENATETLGTHS-RESALLNGNGRDDCKGALTQALEMRENFQKQLQEIMSATSIVRTPAQKTCMSRSSCNSASS--TPDSTRSARSGRSRVLEALRQSRQIVPDINTEPSQNEQIIWDDPTAREERARLASNLQWPSYPTQYSELQVEIKKLD---DSPSRKPVYHSEIAGQASC------VTQAPGQHPGSEEPEAPAAERNLIPEPQAPSVAFPLAKPPVAPQPEDKIETLEETHGKLKKQY-VFQMSSLNSQERIDYCRLIKDLGGSVIEKQC-SDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACRTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSRESG----IAEGAFSGWKVILRVDRPREAGFKRLLQAGGAKVLPGHP----EPLFKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMMESPPCADNYRVSETALFR--NKEGGPGLPQKRKTPAEN-VIKRPRVH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZQF0-1", "uniprot_id": "TOPB1_MOUSE", "id": "Q6ZQF0-1", "name": "DNA topoisomerase 2-binding protein 1", "aln": "---------------------------------------------------------------------------MSRNDQEPFLVKFLKSS-------DNSECFFKALESIKELQSEDYLQIITDEEALKIREN----DKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKS--QEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPK--GQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAETRVEAKM-----VPDTSTPTAQSN---AESHTLADVS------------HISNINGSCVNETMFGSTTSKLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKS--SHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGN-----------QTAVLDK-SGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEALEPEVGPCPGSAHREPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGFSVENKCNIVDIIREHAGKIVSLPSRIVADYAVVPLLGCEVDVTVG-------EVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGVTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETKIPNGVSSNPDLPAHPDAH----LEIHRKKAVTPLDMNRFQSRAFRAVISQQRGQDPTFPPVRQP--------LTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQ-KRKLSSPLSEVIVRNLTVALANSSR----NTDSHSASPQLKGAHLE--EEETRKPLDSVVVCVSKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDINTVQDGRLCN---SRAPLAVSASKDDGPDHLSVEGNETNTMGTND-KESPLLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATCIVKTPAQKTCMSRSSCNSASS--TPDSARSVRSGRSRVLEALRQSRQAVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSDPTQHSELQVEIKMPD---DSPSRKPVYHSEIAEQASC------VTQAPG-HPGSEEPEPPVAERPLIPEPQAPAVASPLAKPPVAPQPADKIETQEETHRKVKKQY-VFQMSSLNSQERIDYCRLIKDLGGSVIEKQC-SDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACKTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSQESG----IVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVLSGHP----EPLLKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMLESPPCADNYRVSEAALFH--NKKGGPGLPQKRKTPAEN-VVKRPRVH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92547-1", "uniprot_id": "TOPB1_HUMAN", "id": "Q92547-1", "name": "DNA topoisomerase 2-binding protein 1", "aln": "---------------------------------------------------------------------------MSRNDKEPFFVKFLKSS-------DNSKCFFKALESIKEFQSEEYLQIITEEEALKIKEN----DRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKS--QEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPK--GQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKT-----MPNSSTPTSQIN--TIDSRTLSDVS------------NISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKS--AHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPES-----------KAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEAR-----PFNDSTHAEPLNDSTHISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEATVG-------EVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTR----LQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQP--------LQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSR----NAVALSASPQLKEAQSE--KEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCN---SRLLSAVSSTKDDEPDPLILEENDVDNMATNN-KESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASS--TPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLE---DSPFQKPLHDSEIAKQAVCDPGNIRVTEAPK-HPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQY-IFQLSSLNPQERIDYCHLIEKLGGLVIEKQC-FDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKIQQRQESG----IVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHS----VPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R8RVN3-1", "uniprot_id": "A0A2R8RVN3_DANRE", "id": "A0A2R8RVN3-1", "name": "", "aln": "---------------------------------------------------------------------------MSKASKDAYIVKFVESNG------QKSDVALQAYKAIVELQSEKYVQMVDEEAALELDHN----DKSLFVFSDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVMDLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKS--QDS-VFHHSELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPT--GQKYEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRS-KEDGPSLLGLS------------HISNIS-LNVNETALTTAGISHIEMPDPVDSFDITVCRV-DDLLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNA--THRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPAL-----------HKAAPRASRPSVAPPPAPSPARQSRAEEDLLSQYMGNDQTVELPQDTSSR-------HSVLHPEPLVEGKDSTLAEAS---------------EGGLFFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAVAHYAIVPLLGCDVEATVD-------EVATDTWLAMCVEQQCVLPLASHPLFTPVAVREGFSPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLHQRSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTPGQEEAKGAQQKDSSLHLDTPSRFLSRDKLFGPSFNTKDVFDHLQTPGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQKAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNSKEYRAVKERGLYIVSQHWLQACADEQKHVSESLYPFTFNPKMSLTMSQMADSTQRSPPSATPRTRLRAFAENEETRLGPDDDITDVSTPKQGSVGEPEKDQTISTEKKNLTETLEMRESLQRQLQEIMSATKLTSGRRGSSRLAKTGPGGLDSPHTPDSLG-RMSRRSRNLEAIRMSRQVCVDLNTEPSQSEQIVWDDPTAREERAKLADNLQWPGSPSQHSEPLALVPPPHSDHTTNGRDSMTDSELVEMAAF--------EVIDAQLKPKGTSSRVDTLHNPKTPEAPSIAFPISKTAALPLPR-----IEDEEEELKKDPPRFLLSSLNPQERIDYSHLIEELGGVVLEKQS-FDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQEDQYEWGSSSILEALPSINSQQKRLALAAMRWRKTLQGCSNKEPNVIVVQGAFGGWIVMLNIDQAREAGFRRLLQSGGAKVLPDPS----PSLFKETTHLFVDFSRLKPGDVRVDISEASAHGVKCLKPEYIADYLMQEPSPSMDAYYLPGAAADE--TEKVVDASSRKRKASGDMSTLKKSRMR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VY97-1", "uniprot_id": "Q9VY97_DROME", "id": "Q9VY97-1", "name": "", "aln": "----------------------------------------------------------------------MSISMSMDETICAYFVNNLKPGDGGVQEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIAAGNLTKKDVFVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRSQREGIMATDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSDLSRISFVSGSRRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSGFRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESIRAGRVVSELVHRVSMPQNREPDVASPASKRTLRSMNHSFKQPTLPIKKKLFDQEPDPVQEQEHEEPDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQMDIRQRVSVANPKPPAEGLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFNQMLTECEAAQGLLVPSSFSDEVDFAIVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALR--QPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKP--------LLVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPE-----------------DFPISPRLR-----DSNSRTARRPNESTLVAQPDVTMEEAENQPAGSVTPVTAGS------------PGAPELTPLRNKRVSELAG-----IPGGSALHRGSNSTSSPDSPCTPLSQVG-----------------------------------------------------------------AQQYNLDFLEQFVQRLDTEEGKDCVREIIREMRENQTPELERIRRQACTPVSRKHQRPAPGIPDFCLTPEFQQRMADDFERRWRLPTMKIKPDTPLAVIRQRVMRITCETLGIEYEESNA-KTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTPLRVSMGSPRSGTQSPFVPNTQSPIEAAPPRRS--------------DGPTLSEEGQSTINFDKISFEESAVPVLAPDVPTVAPDVKQITDYLKNCE-----SRRNSLKRSHDNDMDCG--------ESEVQYVQPFESEGFALGTEDMVDWRDPAEFNAAKRRSSGGSPKMQYAGIPCFSISCGDDD----------EKRAELIARITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPKAIN-LPTLAPEEEPIAAAVHRWRTELSAC---------GGGAFSDHRVILSMNERSGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVDVKKAPLS--TQDMEYLHKCGVQVLSQIAINAYLMNGRDADLGKYQLL-----------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47027-1", "uniprot_id": "DPB11_YEAST", "id": "P47027-1", "name": "DNA replication regulator DPB11", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPFQGITFCPTAINNEILAK----KISKKIIKLGGIFSKDLTRQVNVLVVGSTTN----------------------------------------TNKFKFAVKHRFDIIFIDIQAIDDIYQLWLSGEN----------------ILPDSN-------TATMTGSTYEMLKILYRRFSFKYLHNFNIFIG--------------------------------RITDTN-------------ITSIDSLVRSIKKLGCSSYN----------------------------------------YQNFVIKDTSSHNDDDDQGQNGQISIFVTDTLLGARVNAAIEQNIPIVHFKWILDCQKRSALLPYDPYYLLPNIKDLPYDSIGSNS-----------CDCWDKINTTFPTNIDAQSSLQRQQSSSTLTPSLPKTSSLLNKFKPKGEK------IWDKAMSLQQHSKTNFSVLGQSPLSINNKQEDLSDNSTLIFKNCAFIIHHIFPGNHRSILTKIVVQNGGKIETSYLSGIYDHSYYIIPSNKALDSFN--------------------------------DLPEIIDDNDGIVTEFFIERCLYYQKLLHPIDLWSKPFLSTIEFQVSS----------SSKLLHHEFSSSPFLNVTITGFSGVELLHLTKVLN------------------------------------------------------LLKPMGINYVEYLNKSTDILLINLAALPSIPKTHP-----------------------------------------------------------------------------------------------------------------------------------LWSNEFSDLFTQFCINNNNDDPGDNNRKDFQNN---SILRNSMKRKIEYIKKFHSIPVVTPAFIFK--------------------------LLSAASGENNEIFLNNIKWCIICPRG------HKDDFKCKIKKPYYTSISSEKKYQNNDPKIDKTILLKRNNSSLSEHS---------------------------------------MKDTKNELLQKIRETDSGRKKRSVSSSIMDVSSERQMPDTKRIKLESLP--------KNFVPKQIKRTTSWG----------------------TIMSENVPTEQPTAISNPEEIP------------------------------------RTEEVSHTQVTYGSIQDKKR-------TASLEKPMRRQTRNQTKELDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. . : :. : :: : :** :.: .. *: . . :.:: .: : .: * .: * :.. * . :. . : . : : . . ::.:. . ...: . . : :: : . : : . :* .*:*:. . ::. : . . .... * . . : . . . . : . : .:: : . . . : . .. . * : : . . : :: : :::: . *: .: : . . . * : : . * . . . :: : .. : :: : : : : : . . . : : : .. :. * : . . :.. : . .: . : . :: : : . . : . . .. . .: . * : * : :: * * :. .. ", "identical_positions": 19, "similar_positions": 186, "identity": "1.12%" }, { "cls_id": "homologset.agr.HGNC:17009", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LC42-1", "uniprot_id": "A0ABK0LC42_RAT", "id": "A0ABK0LC42-1", "name": "", "aln": "MSMEQDTRALLPTQGTAWATASVPVARLQGPQGDSHQACSQEPHSPPSAEAPYCDLPRCPPALQDPLHTTTCVGQSVDNLGLGLDQEPQRIGSPTTALPAD-----PRNRHRDPEAIPYLEGPAYS------TDEHKDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTVERPG-VVPNRNRLTMMIPRRPQEGLRTDSAQKV----TRSPARGDTAGQRKENSGSGGQSAGQHWVKLRSESGYFSLERQRSGQTQASSGTPPSGPR-TTTQASSAQRDVSQAASAQEAPQTSSLPRNTQRDTQRS----------------------------------------------TPRTSSPSRVSQRDTPRIMSTQ--------------------------------------RKNTPLSSPLRPTPETLKTSAPE--------------DGPHVTSP----------LCAQ--------DSSLNRTTQ--------------------------------------------------------------------------------------------------------------------------------------------------RDSSRTSCAQRNNPRTSSPNRTTQRDNPRTSCAQRNNPRTSSPNRTTQQDNPRTSCAQRNNPRTSSPSRTTQHDNPRTSCAQRDNPRTSSPNRTTQQDNPRMSCAQRNNPRTSSPNRTTQRDNLRTSCAQRNNPRTSSPNRTIHQDNPRTSCVSQNTPRTS----------------------------------------------STQVDKTTASCSRWEHLRSACTQRD----------NPRTLS-QGCTQKDNPGPSSPHRATQGSSSRNPSPHRTNKDIPWASFPLRPTQSDSSRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPSKLAHNDPPQQ-YSPS----LATSSSSSHNPGHPSASRTSSPLHPAPRGAPQTSLEPSQPPCAVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDAEN--ESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPS-FFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSVDSLHGSPLLLPQVCIGHRDAPRASSPPRHPPSDVGILAPSPPPGSSG-SRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRVPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQARDEGRSQRPSQGQSQ-LRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPEKHSEGDRQLQRIAPPARTSARPPERKAQIERHLESGYTGLRQPLGGWQSREGLSGPQSPNRHPEKNWGSQEEGLSLGGWPELGGPSL------EGIWRGPPQEHRERWGQSEAWEEPPSNGIQGGPPRGQGSLQELPRPHQPPPSPENSWAGPAECFCARQPEAGTAMGWRAEGTSPHQYSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPTRHSRDPAKAPGPEPGSSDTEDTLKTESQTQPEGWAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPPVALEQIDHLESHS------PPDLG--PEEPEASEPSRGEDSLADQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGE-------------WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSEC--NKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKVDGSRQSLDYVELSPLTPSSPQRVRTLSRSTPERPSKQEDLERDLAQRSEERRKWFESTDSRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQGHSERRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDSLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRCCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFT-GKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEA--VRNSLAE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99KW3-3", "uniprot_id": "TARA_MOUSE", "id": "Q99KW3-3", "name": "TRIO and F-actin-binding protein", "aln": "MSMEQDTRALLPTQGTAWATASAPVARLQGPQGDSHQACSQEPHSPSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWSPTTALPAEGPAAAPKNRHQDSEGIPYLEGLARSSCTDDNDNKDEDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTTERPG-VVPSRNRLTEMIPRRPQEGLRADSARKA----TRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPR-GTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRS----------------------------------------------TPRTSSPSRVSQRDTPRVMSTQ--------------------------------------RKNTPLSSPLRATPETLKISAPE--------------DGTHVTPS----------PCVQ--------DSSLNRTSQ--------------------------------------------------------------------------------------------------------------------------------------------------RDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQR--------------DNPRTSCTSQNTPRTP----------------------------------------------STQADKTTASCSKWEHLRSACTQRD----------NPRTFS-QGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQ-YSPS----LATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADN--ESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPS-FFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQVCIGHRDAPRASSPPRHPPSDIGLLAPSPPPGSSG-SRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQTRDEGRSQRPSQAQSQ-LRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPDKRPEGDRQLQRTSPPARTPARPPERKAQIERHLESGHTGPRQSLGGWQSQERLSGPQSPNRHPEKSWGSQKEGPSLGGWPELEGPSL------EGIWRGPPQEHREQWGHSEAWEEPPSNGIQGAPPRGQGRLQELSRPHQPTPSSENSWAGPAECSCALQPEASTAVGWRAEGTSPHQRSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPARHWHDPAKASGPEQGSSGTEDTLKTEPQTQPEGRAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPLAALEQIDHLESHS------PPDLEFQPEEPEASEPSRGEDSRAVQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGE-------------WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDC--NKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKADGPRPSLDYVELSPLAPSSPQRMRTLSRSTPERPTKQEDLERDLAQRSEERRKWFESTDGRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQAHNDRRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPESLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRRCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFT-GKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEA--VRNSLAE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H2D6-1", "uniprot_id": "TARA_HUMAN", "id": "Q9H2D6-1", "name": "TRIO and F-actin-binding protein", "aln": "--MEEVPGDALCEHFEANILTQNRCQNCFHP-EEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPG--PKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTS------LCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESG-LSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELP----------RELGK-RSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDS--NKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPAR-TPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKES--MRNSLAE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IZQ0-1", "uniprot_id": "A0AC58IZQ0_DANRE", "id": "A0AC58IZQ0-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPDLLNFKKGWMSKLDESGE-------------WRKHWFVLTDAGLKYYRDSAAEERDDVDGEIDLKACVKVSEFEVEKNYGFQIQTRDAVFTLSAMTAGIRRNWIEILKKNVRPGSSPDLTQLANCSSDKENTRH-----PSSLRLRSQSEASSAIIN-------SAHNKFDYVELSPIATP-PTPLSTNQRESGEGQVK-EHSQWQETRPSDDAHNQWEAVLSRKGTSQLSE--------------QKRIEEEIERKWAEFERLPLKETRSHPAMRSSNQ--------------ALEREVASLRQQLAEL---GAGQGQGREGSGAGHQCCG--AESRCSDVLQQMERRHRAVMEEQEQRHAQQISALEAQRDTLLQEEAHATATVMEALQKAHREELEKITQLKQTRALDSHTLNKQQQDEVCSLRRELQALSERYSQQCVELKRAQQLRDDSDTQIRLMDTQMEQLRRDKQDLQARLTDEMKLIRSLATGQGS-SAETDDTHRSCCEMQVLLRVRENELQYLHRELNSLRNQLHFLTTEKSSVCARYSEVCEELSVMKSRSERETETLREHLRLALNALMSSNVGVVRSEVC-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3B0C4-1", "uniprot_id": "A0A8M3B0C4_DANRE", "id": "A0A8M3B0C4-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTRLEASLQRSESRSVIEMPSRRESANASRRGSISMSRRESVSQQHSETRRETEQSNGRG--------IFKRANRFLSQDREQDDGSSSSPVRHYERGHALPANHSPERKAAIPFRNPDLGLPSYRRRYDNLS-------------------------------EQAISGLSPQRHMSYSNFRRGDSQSRASPRSGSPRSTN------ISPQRRGESRSSSYRRGSSTHGHRMSSQQASGKCTPSRRRDSIATRTSSPSRSSGTNKYADSYSPAHKRSPSQSSYGHSLDSEKLYKNLKSIVSSAES-----------DGYDERNGWSKRIQSDDGGYNERNHSGRSSRKSGSHRSGYNSRDFSP-------------------------------TGSNCDTIKSRNTGRNSRNSGASTPHRNYDERDTVKNSTSKNKSRRNEVYSDISDKQSKSDSRQSLSPTHSPLSPTSPASTPSIAQSRRSRNQAPTPDLTKSQTLTPETDKP-AIDRSRSNIRRGLEALILSENPRSSSQP----------------------------------------------------------------------------------------------------------------------------AVPEMTIEDYVIIADIPRSKLYP-----------EEEEAIIVRRRPQSRSPRRDNQHSYEDGRYGYEHEVSEERGRGRERERGRDRRE-----------------------------------------------------------------KERRRLDKEMGGSSKANSTTSGHSQKSNKNGDIRMTNGG---------------------------HRGQEKPPPMQGWMYLLDEDEE-------------WRKFWFVITDSGLRYYRDSEAEERDEADGEVYLRHCLRVEEFDADKNYGLQLHMRDGLVTLSAMTSRIRRNWIDTLRRKISFRDSADSIQHLDN-----------SDISDRENSSSQNAPSQTSPAPREPCSDDGGLYEDEPDITCSPLTNRREAGEGRDREHERRLEDRTKWFQEGVSDREGDDPWDKVELKKGGTPVVLTQLQVP--------KAKTGPDIEKKWEDFEQLPIGEKRSLVGSQNPQAAN-----------EALQREVLSLRQQIESLRQVRVGALCG--------------PEAPCALRLQQMEEEHRERLKEIHEQHERERRDMETEKQRLLQEEAKNTLQAMEALRKTHQEEIERLKGHGGEELTDPS--IKQQLHESLSLQRELDGLSQRYSQQCVELNRIQSGTDERDGQIRQKERDMEQLRMENQELQARLTEEISLMRSFITGQRSGVVPLGSYERSTSELEMLLKVKESEVEFLHKEISCLRKEVQTLTKENEALGERYKEVYVELSELRGRSERDINALKQHLKLTDAALEEGRLLGNSDNQ--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q27421-4", "uniprot_id": "OSP_DROME", "id": "Q27421-4", "name": "Protein outspread", "aln": "-----------------MSTTTITTTVPAAPSKSAPPTPTTTGAAGATTNARTADCRKFTPNIFNKSKCSHCFRQREEHSAAALECNRRTSSNLAEP-----------------------------------ASRKVSKCGYLFVAPDWDFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVTGHPNSIAITAPERVTFVKGTSSEESQWWLNILAAFPKSKGRHKRSATLPGGQVVGSLRPTSNGDLTLSTKLGNRHSSYHKDTLTSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSAGNLLSSLDLGPSSTKTAGSPLTTTQSALADDEEDDGVETGEDVDEDEEDETSVPRKSKTVSMGGQDENNRNAGNEITNRVSQPTTCLLIEDIRRDEKTIKDIANTITN---------------------------------------------------------------------------------------------------------------------LSQQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVKKIPTVMEQGDKTKPTARLQLHLK---------SPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLMK-----------------------------QDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQQPSSSPVTPGTPAGPHFSSDEEYRTASEGG----------RRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRSTVDSVASDELPLLVVPEEMQPTESRELKQQCETLRAEASLREARMSELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTISDIDPYCLQRDSLAEEYN-----------------------------------------------------------------------------------------------------------------------------ELRSRFEKAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERRRSLSLKG---------------------------------------------------------------KEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQR--------------------LHSLEHVLLGSKERLEQSLTQLQQ-------------IRAGQRTRRSVSPMNDRKDGLRQLERALAETCVMVSEQMELTCLQDSCHKCCDLRQRVEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQELSEELGRQQERCRRLEKRLELLEREHGKQLECLREVYHTEHANAADEQSFRKRYQTEIEQLRTLCEKGLSAMETSHKRLTMDLEQKHK----------------MEIERLLAEKETALAEETQATLAALDAMRKAHQSEVQR-----------EVARFKQEFLRQVQRGEQMRGDGAKLKEEDLGELRMEILAFSEKYSIKCVENAALEEKLHMANSKLRHFQQMQQLELRNKQFRAHLASDDPSNDVHFVQGLTSDAREDADCEDSEP------APQILGATATRTTATTTTTATATTTSAAPSETESNPDSDRETADSSRAPPEKMEQSLFVIPSHMLNSSLVPAANASDQSQRSQLYRDLDGPEDGYEPCYRPFDIFAIYQNRLSYQGLKGSSTFGKSLRKSAAQTSPASSEITTTTTAPTTDPKKPSHKQMFKTAAVINIQQQVAQEEKAQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : : : . . . *.. .: : .* : . : : . . :: : .***: . : : . * . : . : : : : . . : : * : : .: : . . : ** . .: . : : .: : : . :* :: :: ... : . : : : .: . * : : : . :. ::: : .:: :. . :.* . . . : : : : :: . : .. : . . *:. . : : .: : *: . . .. ", "identical_positions": 15, "similar_positions": 121, "identity": "0.63%" }, { "cls_id": "homologset.agr.HGNC:1701", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62745-1", "uniprot_id": "CD81_RAT", "id": "Q62745-1", "name": "CD81 antigen", "aln": "MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTTLLYLELGDKPAPSTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGS---------------------------NTLTTLTTAVLRNSLCPS----------SSNSFTQLLKEDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P35762-1", "uniprot_id": "CD81_MOUSE", "id": "P35762-1", "name": "CD81 antigen", "aln": "MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTSLLYLELGNKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGS---------------------------NALTTLTTTILRNSLCPS----------GGNILTPLLQQDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P60033-1", "uniprot_id": "CD81_HUMAN", "id": "P60033-1", "name": "CD81 antigen", "aln": "MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGS---------------------------STLTALTTSVLKNNLCPS----------GSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY-----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4KH03-1", "uniprot_id": "A0A0B4KH03_DROME", "id": "A0A0B4KH03-1", "name": "Tetraspanin", "aln": "MGLNGCCSCVKYLMVLINILFWLIGLTIVVTSVWMLTDPT------FMLSMTQNYNHYHIALYVFLAIGILITLGAFFGCCGVCRESQCLLVSFFCVILIVMVAQIAAGAWAFHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNVDRTNIVEIAVSSMNVFYNIPESCCKDNLKDNECELSRRLKFGGPLNNAIYQQGCVDKLIEIIYENWVTIFAVTAAVILLELLSLTFALSLCCAVRNQHYKAXELQNSHREITDDEKY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::** .*:***:.::*::*** * .*: .::*: ** : *. . . :::.:*:::*:* :: : .*:** *. :****** :** ::*::..::*** *.* ***:: . *: ..::*: :. .. .....*:::.*.***: ..: :. : ::.* . .. . : ::.* :*: ::: : * .: .* :: ::.: ::: ***.:**. ", "identical_positions": 59, "similar_positions": 108, "identity": "20.34%" }, { "cls_id": "homologset.agr.HGNC:17010", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZHV0-1", "uniprot_id": "D3ZHV0_RAT", "id": "D3ZHV0-1", "name": "Nucleoporin NUP42", "aln": "MTICQFFLQGRCRFGDRCWNEHPGARGAAGARQPPPQQQPPSGGNRRGWNAGSQRYSNVIQPSSFSKSTPWGGSRGQDKPPFGPFDSGASTSR--GFGSPQNPFASPLSDEQKDEKKLLEGIVKDVEVWESSGQWMFSVYSPVRKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQQLVNQWRSRINELKNLNMSTKGALLSDLKDAVSQAAPAFGFGSKQAGTFGSPGFPVNNSSSTTVQSFSFKTSPGLATAPSGNTSVFGSHPAFGAG----PSAGSAVSSSIPAFGLGKPEATSAASFSFKSPEASSFGSPG----FSGFPAPMATSPFGPATAPAF--GSSVAAFGSPSPHSQTVFAKPCTDVFGGSSISSSVPASS---APDNALFTPRDQLTKEELEQFQSQKFTLGKIPLKPPPVELLTV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CIC2-1", "uniprot_id": "NUP42_MOUSE", "id": "Q8CIC2-1", "name": "Nucleoporin NUP42", "aln": "MTICQFFLQGRCRFGDRCWNEHPGARGAGGARQPPPQQQPPSGNNRRGWNASSQRYSNVIQPSSFPKSTPWGGSRDQDKPPFGSFDSGASTSR--GFGSSQNPFASPLSDEQKDEKKLLEGIVKDVEVWESSGQWMFSVYSPVRKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQQLVSQWRNRINELKNLTMSTKGALLSDVKDGVSQAVPAFGFGSKQAGSFGSPGFPVNNSSSSTVQNFSFKTSPGLATPPSGSTSVFGSHPAFGAG----PSAGSSISSSTPAFGLGKPEATSAASFSFKSPEASSFASPG----FSGFPASMAASPSGSTTAPPLRSGSSVVGFGSPSPHSQAVFAKPSTDVFGGSGISTSVLASG---AADNALFTPRDQLMKEELEQFQSQRFTLGKIPLKPPPVELLTV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15504-1", "uniprot_id": "NUP42_HUMAN", "id": "O15504-1", "name": "Nucleoporin NUP42", "aln": "MAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQP--QQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPYFSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGFTDISPEELRLEYHNFLTSNNLQSYLNSVQRLINQWRNRVNELKSLNISTKVALLSDVKDGVNQAAPAFGFGSSQAATFMSPGFPVNNSSSDNAQNFSFKTNSGFAAASSGSPAGFGSSPAFGAA----ASTSSGISTSAPAFGFGKPEVTSAASFSFKSPAASSFGSPG----FSGLPASLATGPVRAPVAPAFGGGSSVAGFGSPGSHSHTAFSKPSSDTFGNSSISTSLSASSSIIATDNVLFTPRDKLTVEELEQFQSKKFTLGKIPLKPPPLELLNV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P0U9-1", "uniprot_id": "NUP42_DANRE", "id": "Q6P0U9-1", "name": "Nucleoporin NUP42", "aln": "MPVCNFFLQGRCRYGDTCWNEHP-TGGRGGDYRGNQQPSNRGGFGNRVWINPSQRGG--------GGSSSAGGSNEWGRGAASARDVQSSEFS---FSQNRFSALETQRAGAEDTHTTLDTIQKEMEVWQTSGQWPFSCYSAVNR--QISGFIELCPEELRLEYYTSRASGDIQPYINSVQQLANQWRSRVQELRNMSSSTQISVIAELKS-SSPPASAPGFGSPGPG-FGSATSGFGNTSLSSPPAGFGGAGFGSGPQSSSTFSFAQSKTDFGASNTQQASGFGSSAFAQPSSGFGNP-APSAASFSFAAADSESKPSAGGFGSASGFSFKTATAGQGSGFGSGFGSSSGFGSSSGFGSSSGFGSAFGSAAPAQSSSFGSTGGAADT--QSGHGLFTANSELTPEELKEFMAKRFTLGQIPLRPPPADLLMI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9I7N2-1", "uniprot_id": "Q9I7N2_DROME", "id": "Q9I7N2-1", "name": "Nucleoporin NUP42", "aln": "MVVCRFFQQGSCRYGAKCNNEHFDVKQYLKADMESSLNGKMWPLSAYGPFKDKANFPN------------FIQDQSFEEVRFMCYEAKRQNQ----FEQFSQQFNREVLEANNKMKTMLQMSPQVLEMMIKIHETPEGGTVSAAPQQSSNPFAAAAPAAANTSASIFGKP---TLSAGNIFGNATSQASNTNSIFGGTISNANARNSIFGVGAAATGAQSVFGQPQQQQLQPAAQAFQGGNIFAQAQVQVQAQPVNPNPFGGFQQQQQQPQSTGIFG--QAASQNMGGMFTQASQQLQQQQQAAASGLFAQAAASAFPNQQ------QMQQQQQMQQQQQMQQQQMHQQQQMQQ--QQMQQQQQ-FQMQQQQQMMQQQQQQQAQPTN---EIQSSVYSRMEDLNEQEIEAFKADQFLPGALPFKPPPRNLC--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9I7N3-1", "uniprot_id": "Q9I7N3_DROME", "id": "Q9I7N3-1", "name": "Nucleoporin NUP42", "aln": "MVVCRFFQQGSCRYGAKCNNEHFDVKQYLKADMESSLNGKMWPLSAYGPFKDKANFPN------------FIQDQSFEEVRFMCYEAKRQNQ----FEQFSQQFNREVLEANNKMKTMLQMSPQVLEMMIKIHETPEGGTVSAAPQQSSNPFAAAAPAAANTSASIFGKP---TLSAGNIFGNATSQASNTNSIFGGTISNANARNSIFGVGAAATGAQSVFGQPQQQQLQPAAQAFQGGNIFAQAQVQVQAQPVNPNPFGGFQQQQQQPQSTGIFG--QAASQNMGGMFTQASQQLQQQQQAAASGLFAQAAASAFPNQQ------QMQQQQQMQQQQQMQQQQMHQQQQMQQ--QQMQQQQQQFQMQQQQQMMQQQQQQ-AQPTN---EIQSSVYSRMEDLNEQEIEAFKADQFLPGALPFKPPPRNFC--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :*.** ** **:* * *** . . . . .. . : . * :. :. *: : :*: . : . .. . . * .* . . . ..: .. .. :.: . . *. : : . . . **. : .. . . . : .. . * .: . . : : :*** * . :.: . : : . . . . .:. ::: ..* :*:: * :.:* * :*::*** :: ", "identical_positions": 35, "similar_positions": 97, "identity": "8.08%" }, { "cls_id": "homologset.agr.HGNC:17011", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A962-1", "uniprot_id": "D4A962_RAT", "id": "D4A962-1", "name": "", "aln": "---MDVRRLKVNELREELQRRGLDTRGLKAELAERLLAALEAEE----------PEDERELEADDEPGLPGHNN--------EEVETEGGSELEGTAQPPPPGLQPHPEPGGYSG----------------PDGHYVMDNITRQNQFYET--------------PVIKQENES----VYDRRPLDMEP-----------------------PQQAYRPVELKTETKQEAPPSFLPPEAS----QLKT--DRPQFQNRKRPFEENRG---RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSS-GYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEIS--VKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGG-QALYPHVLVKNCAVEFNFGQRAEPYCSIL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGFTFIQHLPLSERIRGTIGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDE-EGKDVPDHAVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDNR-----------------------------------------GGG-FRGRGGGGSFQRYDNR---------------------------GPPGGNRGGFQNR-----------GGGGGSGGGGGNYRGGFNRSGGGGYNQNRWGN--NNRDNNNSNNRGSYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASSYNKNSNIPGSSANTSTPTVSSYSPPQPSYSQPPYNQGGYTQGYTAPPPPPPPPPAYNYGSYGPYN--PAPYTPPPPPTAQTYPQP--SYN-QYQQYAQQWSQYYQNQSQWPPYYGNYD-YGGYSGSTQGGTSTQ--------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VDM6-1", "uniprot_id": "HNRL1_MOUSE", "id": "Q8VDM6-1", "name": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "aln": "---MDVRRLKVNELREELQRRGLDTRGLKAELAERLLAALEAEE----------PEDERELEADDDPGLPGHNN--------EEVETEGGSELEGTAQPPPPGLQPHPEPGGYSG----------------PDGHYVMDNITRQNQFYET--------------PVIKQENES----SYDRRPLDMEP-----------------------QQQVYHP-ELKTEMKQEAPPSFLPPEAS----QLKT--DRPQFQNRKRPFEENRG---RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSS-GYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEIS--VKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGG-QALYPHVLVKNCAVEFNFGQRAEPYCSVL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGFTFIQHLPLSERIRGTIGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTVKRTDE-EGKDVPDHAVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDSR-----------------------------------------GGG-FRGRGGGGGFQRYDNR---------------------------GPPGGNRGGFQNR-----------GGGGGSGGGGGNYRGGFNRSGGGGYNQNRWGN--NNRDNNNSNNRGNYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASSYNKNSNIPGSSANTSTPTVSSYTPPQPSYSQPPYNQGGYTQGYTAPPPPPPPPPAYNYGSYGPYN--PAPYTPPPPPTAQTYPQP--SYN-QYQQYAQQWSQYYQNQSQWPPYYGNYD-YGGYSGSTQGGTSTQ--------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BUJ2-1", "uniprot_id": "HNRL1_HUMAN", "id": "Q9BUJ2-1", "name": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "aln": "---MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEE----------PDDERELDADDEPGRPGHIN--------EEVETEGGSELEGTAQPPPPGLQPHAEPGGYSG----------------PDGHYAMDNITRQNQFYDT--------------QVIKQENES----GYERRPLEME------------------------QQQAYRP-EMKTEMKQGAPTSFLPPEAS----QLKP--DRQQFQSRKRPYEENRG---RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSS-GYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEIS--VKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGG-QALYPHVLVKNCAVEFNFGQRAEPYCSVL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDE-EGKDVPDHAVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDNR-----------------------------------------GGGGFRGRGGGGGFQRYENR---------------------------GPPGGNRGGFQNR-----------GGGSG---GGGNYRGGFNRSGGGGYSQNRWGN--NNRDNNNSNNRGSYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASTYNKNSNIPGSSANTSTPTVSSYSPPQPSYSQPPYNQGGYSQGYTAPPPPPPPPPAYNYGSYGGYN--PAPYTPPPPPTAQTYPQP--SYN-QYQQYAQQWNQYYQNQGQWPPYYGNYD-YGSYSGNTQGGTSTQ--------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RF06-1", "uniprot_id": "A0A8M1RF06_DANRE", "id": "A0A8M1RF06-1", "name": "", "aln": "MSGLNVKKLKVNELKEELQKRGLDTRGLKADLADRLQAALEAEEAGG------APSDEQEKEDFETGGEPGEGS--------DDQEDEFADREQDFGEEAKAQFDDGNSTDLFQGGFDDQENESNGDSTEAPMPGFGSSDAEQKKQFQEP--------------KAMQEYREDEVKQELEESPSHPEPQEEQNFEEPKSRQIPEEDSNKRSQQENSGRYDVKSEYKADEDAPQQAERSSEWDAQAKSEDDRHSSHSRKRSHDESRG---YGYYEHREERRGRSPQPPAEEEEEDIDDNLVVIDTYNCDLHFKVARDRYS-GYPLTIEGFAYLWAGARATYGVNKGRVCFEMKINEEIP--VKHLPSSEPDPHVVRIGWSLDSCSTQLGEEPFSFGYGGTGKKSCNCKFEDYGEKFTESDILGCYIDFESSEEVEIAFSKNGKSLGSCYRVSREELAG-RALFPHVLVKNCAVEFNFGQREEPYFPPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGFTYLQDISLEDRVRGSVGPANKTDCEILMMVGLPGSGKTTWALKYAKENPEKKFNILGTNAIMEKMKVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTLKRTDE-EGKDVPDHAVLEMKANFVLPDVG-EFLDEVRFIELQKEEAEALIKQYNEEGRKAGPPPEKRFDNR-----------------------------------------QSG-FRGRS---NFQRYDNR---------------------------SGPQGNRSGYQNR-----------GSSGG---GGGGFRGGYNR---GGYNQNRWGN--NYRDGG-SGGRGGYNRNQQ---------------------------------SGGNYNHNRQGSYNKTVSTTSGGYSQPQP----QAYNQG-YNQGYTQSSYN----QGYNYSNYSQYPGYSQSYSQAPAATAQTYNQQQQSYNQQYQQYAQQWQQYYQNQSQWNQYYNQYGGYGNYQQGAQGSQGAQGTQ-----------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E1JGL8-1", "uniprot_id": "E1JGL8_DROME", "id": "E1JGL8-1", "name": "", "aln": "MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMSRSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSHSRSKSRSRSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLE-SEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELKRRIAEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGGGGGGGGQQNWMQNNRRSGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQSSYRSGGGTHQQRDFRPGHRDTKEDSRGGYERSAGQSLPKYGNNTAVGGGYDQYKQQGGAPGGGKASLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAAGQQQYWAYNQMQTGYGNQQAWQSADPQQQQQWMSWWQQQQQGSGGAAAGNASGGSGVNVGGGAGNNDGGAANHYWSQYSYSTQSNAGADKK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:.::** :*::*** *****:*:** *.:** * :*. . ::. . * . : * * . : : : .. .. .. . ::* : .: .* : * : ::. * . .. . :: * .* :.:.*. . .*. * .:.: :. : : .. *:* :::. * :. :.***::: : . *** * :: :*:****.***..*:****:::.** .* **. : .*:*:*: ..* *** .*:** **:*: :..* :**. : .*::**: *:* .: : :: **: :* .:...:. *. **:**::.*. .**.: : *:. : :.:.. : *. .: :**::::****.:*** ** *:. .*..*:::::*.:*::.** : * *: : **** : : . :.* * :** :::**:********.*******: *:.*:* *:* *::::** * :: :: :. * : :: :::***.**.: ::*:: : ** :**. :::***:*:** . ..* . .* : ... . : *:** . .. *::** *...* ***. :. :. .**.:. :*. : ** . ...*. . : . : . . . . :.. ..* : .:. . :: . . :: . . : . . * : * :** *.:* : * : . : . .: .. .: ", "identical_positions": 191, "similar_positions": 307, "identity": "15.0%" }, { "cls_id": "homologset.agr.HGNC:17012", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4V7C1-1", "uniprot_id": "CEP43_RAT", "id": "Q4V7C1-1", "name": "Centrosomal protein 43", "aln": "MAATTAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFHPETSTIQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTSVEG-------------------ALDLSDGHPPSKS---------------------------------PEGK--------------------------TSVN-----------------STPSKIPRYKGQGKKKTSGQKSGDKKTSSETSQSEPSVSLSESKSKSSLHSLVHETRIASFLSNSTVDAKDKSALCP--DEDDVEGDSFFDDPIPKPEKTYG---------------------WRSEPRKQVGGLAS-----------------------------LSDK--------------------------PHLRSGLSSLAGAPSLTDAESKRGSTVL------KDLKLVGEKIGSLGLGSGEDEDYVDDFNSASHRSEKSELSIGEEIEEDLSMGVEDVNTSDKLDDLTQDLTVSQLSDVADYLEDVA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q66JX5-1", "uniprot_id": "CEP43_MOUSE", "id": "Q66JX5-1", "name": "Centrosomal protein 43", "aln": "MAATTAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNENLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFHPETSTIQGLEGRENLAQDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPASVEG-------------------ALDLSDGHPPSKS---------------------------------PEGK--------------------------SSAN-----------------STPSKIPRYKGQGKKKTIGQKPGDKKTSSETSQSEPSVSLSESKSKSSLHSLAHETRIASFLSSSAVDARDSSALCP--DGDDVEGDSFFDDPIPKPEKTYG---------------------WRAEPRKQVGGLAS-----------------------------LSDK--------------------------PHLRSGLSSLAGAPSLTDPESKRGSTVL------KDLKLVGEKIGSLGLGTGEDEDYADDFNSASHRSEKSELSIGEEIEEDLSMGVEDGNTSDKLDDLTQDLTVSQLSDVADYLEDVA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95684-1", "uniprot_id": "CEP43_HUMAN", "id": "O95684-1", "name": "Centrosomal protein 43", "aln": "MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEG-------------------ALDLSDVHSPPKS---------------------------------PEGK--------------------------TSAQ-----------------TTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCP--DEDDMEGDSFFDDPIPKPEKTYG---------------------LRKEPRKQAGSLAS-----------------------------LSDA--------------------------PPLKSGLSSLAGAPSLKDSESKRGNTVL------KDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PSK8-1", "uniprot_id": "A0A8M9PSK8_DANRE", "id": "A0A8M9PSK8-1", "name": "Centrosomal protein 43", "aln": "MSAT------EEDTELRDLLIQNLENSGVLNKIKAELRAAVFLALEEQDKVENKTPLVNENLKKSLNTKDGRLVAGLITDFLQVFNLDFTLAVFQPEISTLNGLDSREVLSKELGISESEVNKNSPLLLELVKRGRHREKTSIFTEGDRVADRTFPKELLPRQIAEARKKFDSHDKNRSGEINRDAVIGIFADLFPQFSRNMLDCYVTEELRAKGKDTSSTIDFQDFLGMYKCFFIQCRSVVTSDNSDALYSSSKTTEDKIILSSASKIPRFKGFVKHSSAQEEKADPKAGDRR----PGELLGSPKIRGSVQVSEGSEEESGLGDGKNLPTPLKRALEFGLEDEEEEGDSFFDDPLPKPQKTYGCGLSSAEKPYSGQRHSEKSFSQKDQHSQREGSLSGRFLSQMRRGTSLNDLSAIGSDKEGDGEDMLSDCESRPTPDSERRREGLGGSLGKAFTSGTQLKSAGGSISAESSKKDHSSDKNGTSLSIDKGGKDFSTPNEKTGSPLLD--DDLDYDDDFNSHRSENSKSEVSIDEEIEE---VSIEGPDISDKLDETTQDVSVSQTSLGADYMEDVA", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:** **********:*.********:****************:***********.*** **********.*:::***.**********:** **::**:.** *:::*** *:* . ..*****:::* :::** . ** * . * * :* .:** :* : ::.*****:** *:.: :: .* *:... .. *...* :.*:: . . ..: .. : . .* : :: *********:***:**** : : :: *.*:. *** . *:*. .*::. .* .* .*.:..* * **:. .:* ** *. :* ** ***** ...***:**.***** : ::. : *****: ***::*** * ***:****", "identical_positions": 193, "similar_positions": 115, "identity": "33.39%" }, { "cls_id": "homologset.agr.HGNC:17013", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88875-1", "uniprot_id": "BY55_MOUSE", "id": "O88875-1", "name": "CD160 antigen", "aln": "MQRILMAPGQSCCALAILLAIVNFQHGGCIHVTSSASQKGGRLDLTCTLWHKKDEAEGLILFWCKDNPWNCSPETNLEQLRVKRDPETDGITEKSSQLVFTIEQATPSDSGTYQCCARSQKPEIYIHGHFLSVLVTG--NHTEIRQRQRSHPDFSHINGTLSSGFLQVKAWGMLVTSLVALQALYTL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZBA3-1", "uniprot_id": "D3ZBA3_RAT", "id": "D3ZBA3-1", "name": "CD160 antigen", "aln": "MQ-ILMAPGQSCCALAILLAIVNFQHGGCIHISSSASQKGGRLDFTCTLQYKKDEAEGLILFWCKDRSWNCSPETSLEQLKVKRDPGTDGVIEKSSQLVFTIEQATPSDSGTYQCCARSQKPEIYIHDHFLSVLVTE--NHTEIRQRKRSHPDFSHMNGTLSSGFLQVKAWGMLVSSLVAFQAL---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O95971-1", "uniprot_id": "BY55_HUMAN", "id": "O95971-1", "name": "CD160 antigen", "aln": "---MLLEPGRGCCALAILLAIVDIQSGGCINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQAL---", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*: **:.***********::* ****:::*****:* **:: **: :**:****:::* ***.. :*****.*:**::**** **: * ****:***.*.** .************. * ::.**:*:*.* *:* ::*.* :*** :********* *.* ***:****:*** ", "identical_positions": 110, "similar_positions": 46, "identity": "58.82%" }, { "cls_id": "homologset.agr.HGNC:17014", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A1A5P0-1", "uniprot_id": "BORG5_RAT", "id": "A1A5P0-1", "name": "Cdc42 effector protein 1", "aln": "MPGPQGGTGAPSMSLGKLSPVG-WVPSSHGKR----RLTADMISPPLGDFRHTMHVGRGGDVFGDTSFLSNHGGR-SGNTHRSPRS--------FLARKLQQVRRVGVPPRRMASPAATSPAPPPISPIIKNAISLPQLNQATYDSLVVSKLSFDSTPASSTDGRSGYGLESGFCTISRLPRVEKHSSRDRDHDRDPDHSQDREQSSSPSEPNPNPELRRSDSLLSFRFDLDLGPSLLSELLGVMSLSEAPAAN-------PPAPAANP-APTAKPPADAVTTLDTVTSLPAP--------------TASSPSSGRFPNGVTAVLGPVAEVKASPVGEGPQVPSKMAFDRR-GASWG-------AIRASRHYTEMDARRELAGVLPQVHGSWESLNEEWSAPPASSRAPVPSTVQANAFEFADADEDDEVKV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91W92-1", "uniprot_id": "BORG5_MOUSE", "id": "Q91W92-1", "name": "Cdc42 effector protein 1", "aln": "MPGPQGGTGAPTMSLGKLSPVG-WVSSSHGKR----RLTADMISPPLGDFRHTMHVGRGGDVFGDTSFLSNHGGR-SGNTHRSPRS--------FLARKLQQVRRVGVPPRRMASPAAPSPAPPPISPIIKNAISLPQLNQATYDSLVMGKLSFDSTPASSTDGHSGYGLESGFCTISRLPRVEKHSNRDR--DRDPDHSQDREQSSFPSEPTPNPELRRSDSLLSFRFDLDLGPSLLSELLGVMSLSEAPAAETPVPTANPPAPAANP-APTAKPPAHAITTLDAVTSLPASAVTSL-----PAPAAASSPSRGHFPNGVTSVLGPAAEAKPSPVGEGPQVPSNMTFDRH-GASWGASRASWGASRASRHYTEMDARRELAGVLPQVHGSWESLNEDWSTPPASVRAPVPTSVQVNAFEFADAEEDDEVKV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q00587-1", "uniprot_id": "BORG5_HUMAN", "id": "Q00587-1", "name": "Cdc42 effector protein 1", "aln": "MPGPQGGRGAATMSLGKLSPVG-WVSSSQGKR----RLTADMISHPLGDFRHTMHVGRGGDVFGDTSFLSNHGGS-SGSTHRSPRS--------FLAKKLQLVRRVGAPPRRMASPPAPSPAPPAISPIIKNAISLPQLNQAAYDSLVVGKLSFDSSPTSSTDGHSSYGLDSGFCTISRLPRSEKPHDRDR-------------DGSFPSEPG----LRRSDSLLSFRLDLDLGPSLLSELLGVMSLPEAPAAETPAPAANPPAPTANPTGPAANPPATTANPPAPAANPSAPAATPTGPAANPPAPAASSTPHGHCPNGVTAGLGPVAEVKSSPVGGGPRGPAGPALGRHWGAGWD----------GGHHYPEMDARQERVEVLPQARASWESLDEEWRAPQAGSRTPVPSTVQANTFEFADAEEDDEVKV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1P8I7-1", "uniprot_id": "A0A8M1P8I7_DANRE", "id": "A0A8M1P8I7-1", "name": "", "aln": "------------MSLGKLPAIKGLVSTSQSRRRFKSELSVDMISPPLGDFRHTMHVGRGGDVFGDTSFLSNYGGSGHSDAQRCPDSPPGSKTTRFLSRTLQHVRKTPAPRPRGGS-RDFSSPPPPISPIIKNAISLPQLNLS--NGGLM-RTMLHTSTSSPDRPLCSYGLPSGFVTLPRFSRLDQ------SFAEAPESPR---TDSRRSSE---VSLSPSDSLS--SFTVDLGPSLMTEVLEIIDN-----------------------------------SCSLLKSREEED-----------------------EDQRS--AGSDRENQ--LSDDSVLRSVT----------------------------------ADVAIEPRRFQQAASMLARHFGGRAEEERQRPSSFRHTRTPYSFTETEEEIKV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B274-1", "uniprot_id": "A0A8M2B274_DANRE", "id": "A0A8M2B274-1", "name": "", "aln": "------------MNLGKLSGLKGLVSHSSGKRRFKGDLTPEMISPPLGDFRHTMHVGRGGDVFGDTSFLSNHGGAGNNADAESSTS---EKNEGFFTRTLRHVRKTPD-RPRGGS-KDLSPPPPAVSPIIKNAISLPRLDVDSPNGCPV-KVLFPSSPKTPENSTYLYGLESGFVTLPRLSRTERPAQGSSPSACPPEIHRGSLTDTNIPSLPCSDSISPSDSMN--SFTLDLGPSLMSEVFALIDSPMCEKPD-----------TISEKAQSVEYNSDSDATTSLVDSLLRED-----------------------DDGRTRLYGGEWKNSDFVNDESPKKSTTGDQLRS-------------------------FPIEDRGMEPESFQRAADVLARHYG--SGGLRNTNTNNSHRRAPYCYPDEDEEIKV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.****. : *. * .:* *: :*** **************************:** . ... * *:::.*: **:. * .* *..**.:***********:*: :. : : : ::. :. *** *** *:.*:.* :: .: .. : ***: : :******::*:: ::. . . : : * : . . . . : *. .: : :. :. .: ::*:**", "identical_positions": 86, "similar_positions": 81, "identity": "19.91%" }, { "cls_id": "homologset.agr.HGNC:17015", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99LL5-1", "uniprot_id": "PWP1_MOUSE", "id": "Q99LL5-1", "name": "Periodic tryptophan protein 1 homolog", "aln": "MNRSRQ-------VTCVAWVRRGVAKETPDKVELSKEEVNRLIAEAKGKLQEEGG-SEEEEAGNPSEDGMQSGPTQAPPRESLEDGDPQDDRTLDDDELAGYDLDNYDEEDNPDAETIGESLLGLTVYGSNDQDPYVTLKDTEQY--EHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQ--------------------------EEESFYVHHDILLSAYPLSVEWLNFDPSPDA-STGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLS--------KKKKKKGKKSSSAEGHTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHT--DKVQTLQFHPFEAQTLISGSYDKSVALYDCRDPS---QNHRQWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS---DKPIFTLNAHNDEISGLDLSSQIKGCLVT-ASADKFVKIWDILGDRPS------LIHSRDMKMGVLFCSSCCP--DLPFVYAFGGQKE-GLRVWDISTVSSVNEAFGRRERLVIGGTKG-LSVSGPCGSRSPQQTPMES---------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LFY1-1", "uniprot_id": "A0ABK0LFY1_RAT", "id": "A0ABK0LFY1-1", "name": "Periodic tryptophan protein 1 homolog", "aln": "MNRSRQ-------VTCVAWVRRGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGG-SEEEEVGSPSEDGMQRARVQARPTEPLEDGDPQDDRTLDDDELAEYDLDNYDQEDNPDAETIGESLLGLTVYGSNDQDPYVTLKDTEQY--EHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQ--------------------------EEESFYVHHDILLSAYPLSVEWLNFDPSPDA-ATGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLS--------KKKKKKGKKSSSAEGHTDAVLDLSWNKTVRNVLASASADSTVILWDLSVGKPAARLTAHT--DKVQTLQFHPFEAQTLISGSYDKSVALYDCRDPS---QNHRLWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS---DKPIFTLNAHNDEISGLDLSSQIKGCLVT-ASADKFVKIWDILGERPS------LIHSRDMKMGVLFCSSCCP--DLPFVYAFGGQKE-GLRVWDISTVSSVNEAFGRRERLAIGSTKDPWDPLHLAGEDSARKTTGKA---------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q13610-1", "uniprot_id": "PWP1_HUMAN", "id": "Q13610-1", "name": "Periodic tryptophan protein 1 homolog", "aln": "MNRSRQ-------VTCVAWVRCGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGGGSDEEETGSPSEDGMQSARTQARPREPLEDGDPEDDRTLDDDELAEYDLDKYDEEGDPDAETLGESLLGLTVYGSNDQDPYVTLKDTEQY--EREDFLIKPSDNLIVCGRAEQDQCNLEVHVYNQ--------------------------EEDSFYVHHDILLSAYPLSVEWLNFDPSPDD-STGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLS--------KKKKKKGKKSSSAEGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHT--DKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPD---ESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS---DKPIFTLNAHNDEISGLDLSSQIKGCLVT-ASADKYVKIWDILGDRPS------LVHSRDMKMGVLFCSSCCP--DLPFIYAFGGQKE-GLRVWDISTVSSVNEAFGRRERLVLGSARN-SSISGPFGSRSS-DTPMES---------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1Z8D0-1", "uniprot_id": "PWP1_DROME", "id": "A1Z8D0-1", "name": "Periodic tryptophan protein 1 homolog", "aln": "MAEEGPPEPSIDFVPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELDEESD--DDAEEGENAEEDQNDMDVDDHADANSENRDPQD----------EFQFQEYDNEANANVTSLAN------IVDAGEQIP----DEDEDS--EAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQ--------------------------EEEALYTHHDFLLPSFPLCIEWMNHDAGSE--KAGNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGS--------RKQNKE------QYGHKDAVLDLSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITAFG--KQIQSLEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSP--GQLLWSVKAHNEEISGVCFNNQKPNLLTS-TSTEGTLKVWNFDGTEAK------HVYEHEFNMGRLQCMRQCP--EDPYTLAFGGEKPPRCAIFNIKNSIAVRRTFG------IPDAE------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P21304-1", "uniprot_id": "PWP1_YEAST", "id": "P21304-1", "name": "Periodic tryptophan protein 1", "aln": "------------MISATNWVPRGFSSEFPEKYVLDDEEVERINQLAQLNLDDAKATLEEAEGESGVEDDAATGSSNKLKDQLDIDDDLKEYNLEEYDD--EEIADNEGGKDVSMFPGLSNDSDVKFHEGEKGEDPYISLPNQEDSQEEKQELQVYPSDNLVLAARTEDDVSYLDIYVYDDGAGFHSSDIPVEEGDEADPDVARGLVRDPALYVHHDLMLPAFPLCVEWLDYKVGSNSEEAANYAAIGTFDPQIEIWNLDCVDKAFPDMILGEPLDNSMVSLKSKKKKKKSKTGHITTHHTDAVLSMAHNKYFRSVLASTSADHTVKLWDLNSGNAARSLASIHSNKNVSSSEWHMLNGSILLTGGYDSRVALTDVRISDE-SQMSKYWSAMAGEEIETVTFASENIILCGTDSGNVYSFDIRNNENRKPVWTLKAHDAGISTLCSNKFIPGMMSTGAMGEKTVKLWKFPLDDATNTKGPSMVLSRDFDVGNVLTSSFAPDIEVAGTMVIGGVNK-VLKLWDVFTNRSVRKSFKSELENVQARAKEEAQKIGKSSRIARKYTSNDNPDTVITIDDQGEDEEEREGGDEHDDMA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. :* *.:.: *:* * . *: *: :: :*:: :: * . *:. : : * :: :: . : . :.: . : * : *: * :: : *:***:: .:.::: . ::: *::: .: ::*.***::*.::**.:**::.. ..: :.* *:* : * * :*:** * * : **. . :*::*: *.****.:: *. .. :*** *.* ** ***:. *:. :: .::.: ::* :.. :::* * * * * * .. . * . * . :: .*:.* :: * *. : :::::**: ** : .. . : : : : :*:*.: .. : .:::.:* : .* : . .:** : :::: . :*..:* :. ", "identical_positions": 84, "similar_positions": 176, "identity": "14.19%" }, { "cls_id": "homologset.agr.HGNC:17016", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5SVQ0-1", "uniprot_id": "KAT7_MOUSE", "id": "Q5SVQ0-1", "name": "Histone acetyltransferase KAT7", "aln": "---------------MAIGVVKRNAGSSSDGTEDSDFSTDLEHTDSSES----------DGTSRRSARVTRSS--------------------ARLSQSS---QDSSP--VRNLPSFG----TEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSG------------------SETEQVVDFSDRETKN----------------------TADHDESPPRTPTGNAPSSESDIDISSPNVSHDES----------------------------------------------IAKDMSLK----------DSGSD---------LSHRPKRRRFHESYNFN-------------------------------MKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEER--MLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTG---------CHLIGYFSKEKNSFLN----YNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQG--------------KEISIKEISQETAVNPVDIVSTLQALQMLKYWKGK--------HLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTP-----PKGT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95251-1", "uniprot_id": "KAT7_HUMAN", "id": "O95251-1", "name": "Histone acetyltransferase KAT7", "aln": "-----------------MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSES----------DGTSRRSARVTRSS--------------------ARLSQSS---QDSSP--VRNLQSFG----TEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSG------------------SETEQVVDFSDRETKN----------------------TADHDESPPRTPTGNAPSSESDIDISSPNVSHDES----------------------------------------------IAKDMSLK----------DSGSD---------LSHRPKRRRFHESYNFN-------------------------------MKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEER--MLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTG---------CHLIGYFSKEKNSFLN----YNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQG--------------KEISIKEISQETAVNPVDIVSTLQALQMLKYWKGK--------HLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTP-----PKGT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q810T5-1", "uniprot_id": "KAT7_RAT", "id": "Q810T5-1", "name": "Histone acetyltransferase KAT7", "aln": "---------------MAIG-VKRNAGSSSDGTEDSDFSTDLEHTDSSES----------DGTSRRSARVTRSS--------------------ARLSQSS---QDSSP--VRNLPSFG----TEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSG------------------SETEQAVDFSDRETKN----------------------TADHDESPPRTPTGNAPSSESDIDISSPNVSHDES----------------------------------------------IAKDMSLK----------DSGSD---------LSHRPKRRRFHESYNFN-------------------------------MKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEER--MLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTG---------CHLIGYFSKEKNSFLN----YNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQG--------------KEISIKEISQETAVNPVDIVSTLQALQMLKYWKGK--------HLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTP-----PKGT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VM15-1", "uniprot_id": "Q9VM15_DROME", "id": "Q9VM15-1", "name": "Histone acetyltransferase", "aln": "MALESGSSSSESGSSSTSGSTSSETGSSSDTDSSSATPEEKPSTNSSAKSQTQTQQQTNSGNAQRRKPVPAASEDKPKPSVAPSSKKVNNPPKSKLSSDDDEYEDSAPPAKKNSRAMGSSTVTAAAAASAARRKPPASVNKPSNPANKPSNPTQRSANNNTNRSLENGEGKRPSLSSSSNSTDDSMKIVKNGRKVPLKMASTVRPKQIRGKLPPAKKNGGGPVISSDGSSGSESGSNSGDESSSGSESEGSDSSNSYSSQPVKGGAKGKRSGPTKIQNSDSEEERKDKANPMRKLTRSLSMRRTKQQPKQETDSESDGDLEDDKIMISKSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQTEKKCPIEGCDSSGHLSGNLDKHFLPEACPIYHNMSASECKERANERKLRNEQRLKMPVNIVTAPGNQNTNLKTLSPEQREFLAKIRESRANFKPANNNFLDSKVKLEKDVTDEDREPNLAGLVPDYDLQLFREAQAQASERIEDELKDLPVGKG---IKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHKTLYYDVEPFLFYIMTLADVDG---------CHIVGYFSKHIPFLQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDVLLDYLCNRSG--------------NTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGK--------HIVLKKQDVLDEYEERVKRRG-TFPKIDDSCLRWQPFINIQPSSSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34218-1", "uniprot_id": "SAS3_YEAST", "id": "P34218-1", "name": "Histone acetyltransferase SAS3", "aln": "---------------MSLTANDESPKPKKNALLKNLEIDDLIHSQFVRS----------DTNGHRTTRRLFNS----------------------------------------------------DASISHRIRGSVRSDKGLNKIKKGLISQ-----------------------QSKLASENSSQNIVN----------------------------RDNKMGAVSFPIIEPNIEVS---------------------------------------------------------EELKVR------------------------IKYDSIKFFNFERLISK-----------------------------------------SSVIAPLVNKNITSSGPLIGFQRRVNRLKQTWDLATENMEYP--------YSSDNTPFRDNDSWQWYVPYGGTIKKMKDFSTKRTLPTWEDKIKFLTFLENSKSATYINGNVSLCNHNETDQENEDR-KKRKGKVPRIKNKVWFSQIEYIVLRNYEIKPWYTSPFPEHINQNKMVFICEFCLKYMTSRYTFYRHQLKCLTFKPPGNEIYRDGKLSVWEIDGRENVLYCQNLCLLAKCFINSKTLYYDVEPFIFYILTEREDTENHPYQNAAKFHFVGYFSKEKFNSND----YNLSCILTLPIYQRKGYGQFLMEFSYLLSRKESKFGTPEKPLSDLGLLTYRTFWKIKCAEVLLKLRDSARRRSNNKNEDTFQQVSLNDIAKLTGMIPTDVVFGLEQLQVLYRHKTRSLSSLDDFNYIIKIDSWNRIENIYKTWSSKNYPRVKYDKLLWEPIILGPSFGINGMMNLEPTALADEALTNETMAPVISNNTHIENYNNSRAHNKRRRRRRRSSEHKTSKLHVNNIIEPEVPATDFFEDTVSSLTEYMCDYKNTNNDRLIYQAEKRVLESIHDRKGIPRSKFSTETHWELCFTIKNSETPLGNHAARRNDTGISSLEQDEVENDVDTELYVGENAKEDEDEDEDFTLDDDIEDEQISEENDEEEDTYEEDSDDDEDGKRKGQEQDENDIESHIRKERVRKRRKITLIEDDEE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. ...: .. : :: . . ..:* * * : * . . . : .:. : * : * : . . *.. : . ..:.:: :. . : . . . :: :::: .. : .: ... * : . * .. . : : .: : : . ..* .. . : . .. : : . : : : *: * : .*::. ** **:*:. : :::*****:* .*. : ** **: :***:****.*.:.*:::**:. ***:****** *:: **********:**::* : *::*****. : **:*****:* * *:***::*::*****:: * *.*:**:*******::**::** * : . : :::::::: *.: . *:* *: * :: * : : ::* :. . . :. . * * * . . ", "identical_positions": 115, "similar_positions": 175, "identity": "10.51%" }, { "cls_id": "homologset.agr.HGNC:17017", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P62312-1", "uniprot_id": "LSM6_HUMAN", "id": "P62312-1", "name": "U6 snRNA-associated Sm-like protein LSm6", "aln": "MSLRKQTP----SDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIAL-EQTEEY--VNGQLKNKYG-DAFIRGNNVLYISTQKRRM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P62313-1", "uniprot_id": "LSM6_MOUSE", "id": "P62313-1", "name": "U6 snRNA-associated Sm-like protein LSm6", "aln": "MSLRKQTP----SDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIAL-EQTEEY--VNGQLKNKYG-DAFIRGNNVLYISTQKRRM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZG07-1", "uniprot_id": "D3ZG07_RAT", "id": "D3ZG07-1", "name": "U6 snRNA-associated Sm-like protein LSm6", "aln": "MSLRKQTP----SDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIAL-EQTEEY--VNGQLKNKYG-DAFIRGNNVLYISTQKRRM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9W2P5-1", "uniprot_id": "Q9W2P5_DROME", "id": "Q9W2P5-1", "name": "U6 snRNA-associated Sm-like protein LSm6", "aln": "MS-RKEAL----SQFINQIHGRPVAVKLNNGVDYRGVLACLDGYMNICL-EQTEEY--VNGQLKNKYG-DAFIRGNNVLYISTQKRRV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06406-1", "uniprot_id": "LSM6_YEAST", "id": "Q06406-1", "name": "LSM complex subunit LSM6", "aln": "MSGKASTEGSVTTEFLSDIIGKTVNVKLASGLLYSGRLESIDGFMNVALSSATEHYESNNNKLLNKFNSDVFLRGTQVMYISEQKI--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** : .: ::*:.:* *:.* *** .*: * * * .:**:**:.* . **.* *.:* **:. *.*:**.:*:*** ** ", "identical_positions": 35, "similar_positions": 28, "identity": "39.77%" }, { "cls_id": "homologset.agr.HGNC:17018", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6NZC7-1", "uniprot_id": "S23IP_MOUSE", "id": "Q6NZC7-1", "name": "SEC23-interacting protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADRKANGG-------------------------------------------------------------------------GASASSSGTNLLFSSSATEFSFNVPFIPVTQAAASPASLLLPGEDSTDVGE----------------EDSFLGQTSTHTSTPQTFSYFSQVSSSSDPFGNIGQS-------------------------------------------PLTTSAMSAGQSA-------------LPKPPATLAFTTGSQDALSAFPPS-----------VSKAP-GATPPSQMGTSTYSPSQ----------------------------------------------------------------PSSLPPN-FGSPPQGIPQQG----------------------------------------------------------------------------------------------------------------HNPYRHTPVSSRANPYITP-------PQLQQCQMPGH---------------------------------------------------------------------------------------------SSYPPP--------------------------SGPPVQTYQMPPG--------------------------------------PLPPLPTAMQSPAQQQVPARP-------------------------------AGPLVQGPSPFVLQN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYEPVQPHWFYCKEVEYKQLWMPFSVLDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRMRKSVYWEEEPTEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVSTN---QWHRRLEFPSGETIVMHNPKVIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDSLDEIPDGEMPQVDHLVFMVHGIGPVCDLRFR--SIIECVDDFRVVSLKLLQT-----HFKKSVDEGKVSRVEFLPVHWHSALGGHATGVDRNIKKITLPSIG--------RFRHFTNETLLDVLFYNSPTYCQAIVEKVEVEINRLHSLFMSRNPNFKGKVSVAGHSLGSLILFDILSNQRDMCVSKSPGSVAVSNGVIKHSQFQEKLISEESKLMSDESCDLDVEDEEPLTLHGTLEALSLFDYISTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVKLKAAKLEQKKAAAEKKAALAALTKGQDESAPKTKEMASPSSESNESKRKLSVGAYVSSVRVDYESFEVGTGQVSVAYSSLDFEPEIFFALGSPIGMLLTIRGVARID-----------EKYRLPTCKGFFNIYHPLDPVAYRLEPMIAPDLD-LKAVLVPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSTTQLQEELEKVANQIKEEEEKQVVEAK--------------KKKESPELSKDEDYLG---KVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWGSEDTALLLLKEIYRTMNISPEQPQH-----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V8Q8-1", "uniprot_id": "G3V8Q8_RAT", "id": "G3V8Q8-1", "name": "SEC23-interacting protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADRKANGG-------------------------------------------------------------------------GASASSSGTNLLFSSSATEFSFNVPFIPVTQAAASPASLLLPGEDSTDVGE----------------EDSFLGQTSTHTSTPQTFSYFSQVSSSSDPFGNIGQS-------------------------------------------PLATTAMSAGQSA-------------LPKPPATLPFTTGSQDMLNAFPPS-----------VSKAPYGAAPSSQMGASTYLPSQ----------------------------------------------------------------PSSLPPN-FGSPPQGIPQQG----------------------------------------------------------------------------------------------------------------HNPYRHTPVSSRANPYITP-------PQLQQCQTPGH---------------------------------------------------------------------------------------------PSYPPP--------------------------SAPPVQTYQMPPG--------------------------------------PLPPLPTAVQSPAQQQVPARP-------------------------------AGPLVQGPSPFVLQN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYEPVQPHWFYCKEVEYKQLWMPFSVLDSLNLEEIYNSVQPDPENVVLGTDGGRYDVYLYDRMRKSVYWEEEPAEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVTTN---QWHRRLEFPSGETIVMHNPKVIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDNLDEIPDGEMPQVDHLVFMVHGIGPVCDLRFR--SIIECVDDFRVVSLKLLQT-----HFKKSVDEGKVSRVEFLPVHWHSALGGHATGVDRNIKKITLPSIG--------RFRHFTNETLLDVLFYNSPTYCQSIVEKVGVEINRLHSLFMSRNPNFKGKVSVAGHSLGSLILFDILSNQKDMSISKSPGSVAVSNGVTKHSNFQEKQVSEESKLMSDESCDLDVEDEEPLTLHGTLEALSLFDYISTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVKLKAAKLEQKKAASEKKAALAALTKGQGESAPKTKEMASPSSESNESKRKLSVGAYVSSVRVDYESFEVGTGQVSVAYSSLDFEPEIFFALGSPIGMFLTIRGVDRID-----------ESYRLPTCKGFFNIYHPLDPVAYRLEPMIAPDLD-LKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAE--------------KIVESPEFSKDEDYLG---KVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNISPEQPQH-----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y6Y8-1", "uniprot_id": "S23IP_HUMAN", "id": "Q9Y6Y8-1", "name": "SEC23-interacting protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERKPNGGSG-----------------------------------------------------------------------GASTSSSGTNLLFSSSATEFSFNVPFIPVTQASASPASLLLPGEDSTDVGE----------------EDSFLGQTSIHTSAPQTFSYFSQVSSSSDPFGNIGQS-------------------------------------------PLTTAATSVGQSG-------------FPKPLTALPFTTGSQDVSNAFSPS-----------ISKAQPGAPPSSLMGINSYLPSQ----------------------------------------------------------------PSSLPPSYFGNQPQGIPQPG----------------------------------------------------------------------------------------------------------------YNPYRHTPGSSRANPYIAP-------PQLQQCQTPGP---------------------------------------------------------------------------------------------PAHPPP--------------------------SGPPVQMYQMPPG--------------------------------------SLPPVPSSVQSPAQQQVPARP-------------------------------GAPSVQVPSPFLLQN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYEPVQPHWFYCKEVEYKQLWMPFSVFDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRIRKAAYWEEEPAEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVTTN---QWHRRLEFPSGETIVMHNPKVIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDNLDEIPDGEMPQVDHLVFVVHGIGPVCDLRFR--SIIECVDDFRVVSLKLLRT-----HFKKSLDDGKVSRVEFLPVHWHSSLGGDATGVDRNIKKITLPSIG--------RFRHFTNETLLDILFYNSPTYCQTIVEKVGMEINHLHALFMSRNPDFKGGVSVAGHSLGSLILFDILSNQKDLNLSKCPGPLAVANGVVKQLHFQEKQMPEEPKLTLDESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKL--KKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRID-----------ENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLD-LKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAE--------------KVVESPDFSKDEDYLG---KVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNISPEQPQH-----------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VLS7-1", "uniprot_id": "Q9VLS7_DROME", "id": "Q9VLS7-1", "name": "", "aln": "MSERSKGDVSARVNNNANQTRVVKNPLLSASVTGLSFDDFPNKPQLLPAAPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNTSSEDSVGAGGSSPYLGAGDQNANPLLEPPTEAGNDSLLSQAASSFTALPAVASNVFSTFSKRIYAGSRETSEEPKLDIQPSYIQQASYVQPVAPVPAPFYAAPPAAANEVVAPEPPKFYAPTEVPPPNVGVPAPPPTSGNPNTYRFTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPYPPQLTYAANPAPFDISAQPAAIPAEERKSGGGLFSLTSLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLVQEPISNQGIPFFAPPQTNIFTPQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPSVSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLVQETKPELVPPPIGFFAPKSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIGFDLLNQTQQASSLVENSNQNSSVNSFDGYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQVPQTQSQIQQANEDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPSSACSEFSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQVATPPVAIPYSPVVAHWFYKRSVDTKFIWTPFSHYDSALLETSLN---LDDSTLIIPVEGGRYDVNIKERTKTPVYWEGKAIEVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETG---EWHQKIMLANGEQVVFHGPTVIVHFLPQQNADTWGASTQGSMRPRVVKRDLDD--FTIEQGESQRVDHLLFMVHGIGSACDLKMR--SVEEVVDDFRVIAQQLVQS-----HYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIP--------RLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQEPLKESE--------------------------------------------------------------------------------------------------------------------------------EENKENPDQLPQKQSSQKVQLPTSDPLPKQVSYAMGPEGTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLG-----------LDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIYASLGISTDSQVPQSSMTIERPVSHESSVSHSLLPM", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12204-1", "uniprot_id": "YOR22_YEAST", "id": "Q12204-1", "name": "Probable phospholipase YOR022C, mitochondrial", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRFTHRGLPSSTRFRNIFVRLNHIYVP---------WFYAIDVPNSKP--------------------YLPTYQTLHSPKKFKPFSVDDSNR-----------------------------------------------------LEKASKRQERRP------------VLVNEDYLFKVDLSHMELSPTYWEG--------------------PTYQVRRGVWFDSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQPLSSDLTSEIEG-----LYKQLKFDDSNDD---------------------------------------------------------------------------------------------PTTTPP---------------------------AESQDIFRLKG------------------------------------------KYPVDKENEGEQKNGSSN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDENESTFKFILFANKQTAFLLSDLDG--GKLQLAFLRSNLAQSLPINATMITRSYKYSSSATTKQTSTSFKAAKTPQTEVADGSNSSKSRSIETKLEKKVSNLFNLSDFLQLFNGNASKDQDDAQSLEKQMETDYNNADNSQGANASSKIEDGKNSGASDRQIRSNRRDVDNLILCVHGIGQTLGKKYEYVNFAHTVNLLRSNMKKIYNNSEKLQSLNTAPDYKSNCNVQVLPITWRHSISFQTDAKEENIENPDLPTLSQVTVNGVLPLRKLLADGLLDILLYVEPYYQDMILQQVTSQLNKTYRIFKEFNPEFDGKVHLVGHSLGSMILFDILSKQK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYELEFQVDNLFFIGSPIGLLKLIQRTKIGDRPEFPNDLERKLTVQRPQCKDIYNVYHVCDPISYRMEPLVSKEMAHYEQTYLPHCSEAYGLTSKVLEFGENIWKDLPG----------TDENNLQSKKTSPEKKEVKLSENLTRMLTG----------------------------------------------LNYTGRLDYAMSPSLLEVD--FISAIKSHVSYFEEPDIAAFILKEILSKHENASEIYVKRKTG-------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .: .. :: : *. : .. : * . . .. : . : : : : : . . : . *. : .. : * *. . : **: . .** . . : * . . : : . : . : *: :: * : . . .: : .: . :. .. : .: * . . . :. .: : . * * .. : : : .*: :. :. . : . : .. .:: . .. .: **:*:: ***** . . : . .. . *: :* :: .. :.: * .*:.**: *: : . . :.:::. * :: :*:: : ***:*:* .* * : *:: * :* : : :*:*.* * :.******:****:*.:*. .* *. . :* :****.:: *: . * * .::*::* **::**:*.:: :: . . :** . : :: * .: *: * : . : : .*.: .: ** *:**.:. :* :: *:.**:.*: . * :::*** . :.: ", "identical_positions": 96, "similar_positions": 223, "identity": "4.41%" }, { "cls_id": "homologset.agr.HGNC:17019", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q71QF9-1", "uniprot_id": "PRIC1_RAT", "id": "Q71QF9-1", "name": "Prickle-like protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPLE---------MEPKMS---KLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAG-PGVCWRPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDVSLSG-QGAGFAHEEFWKARVDQEASED-PEEWAEHEDYMTQLLLKFGDKNLFQQPPSEVDMRASEHWIPDNMVTN--KPEAKQNHQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHG-AAGYNHDQTQWYEDSLECLSDLKPEQ--SVRDSMDSLALSNITGASVDGESKPRPSLYSLQNF--EEIEAEDCEKMSNMGTLNSSMLHRSAESLKSLNSELCPEKIIP-------------------EEKPVHLPVLRRSKSQSRPQ----QVKFSDDVIDNGSYD-IEIRQPPMSERTRRRVYHFEERGS-----RP---HHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQSKGARELQAYMQNANLYGQYAHTTSDYALQ-NPGMTRFLGLYGDD-DDSWCS-SSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFNQRTTKSKKKKGHRGKNCIIS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3U5C7-1", "uniprot_id": "PRIC1_MOUSE", "id": "Q3U5C7-1", "name": "Prickle-like protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPLE---------MEPKMS---KLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAG-PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKARVEQEASED-PEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMVTN--KPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHG-AAGYTHDQSQWYEDSLECLSDLKPEQ--SIRDSMDSLALSNITGASVDGESKPRPSLYSLQNF--EEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILP-------------------EEKPAHLPVLRRSKSQSRPQ----QVKFSDDVIDNGSYD-IEIRQPPMSERTRRRAYHFEERGS-----RP---HHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSARELQAYMQNANLYSQYAHATSDYALQ-NPGMNRFLGLCGED-DDSWCS-SSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96MT3-1", "uniprot_id": "PRIC1_HUMAN", "id": "Q96MT3-1", "name": "Prickle-like protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPLE---------MEPKMS---KLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAG-PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSR-QGTSFASEEFWKGRVEQETPED-PEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKS--KTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHG-ASGYNHDETQWYEDSLECLSDLKPEQ--SVRDSMDSLALSNITGASVDGENKPRPSLYSLQNF--EEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILP-------------------EEKPVHLPVLRRSKSQSRPQ----QVKFSDDVIDNGNYD-IEIRQPPMSERTRRRVYNFEERGS-----RS---HHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATSDYGLQ-NPGMNRFLGLYGED-DDSWCS-SSSSSSDSEEEGYFLGQPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q6J9-1", "uniprot_id": "F1Q6J9_DANRE", "id": "F1Q6J9-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELENRG---GLHMGSKVN---KLTLGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVALYFSCLPEDKVPYVNSPGEKQRIKQLLYQLPPHDNEVRYCQSLSEEEKKELHMFSIQRKKEALGRGTLKILPRTVHHAACEHCGERLGGGEMAVCVSRAAAAGQCWHPACFTCSTCSELLVDLIYFYHDGKVHCGRHHAELLKPRCSSCDEIIFADECTEAEGRHWHMKHFSCSECEVILGGQRYIMKDGRPFCCGCFQSLYAEYCQACAQHIGVDHAQMTYDGLHWHATDACFSCAQCKSSLLGCPFLPRQGRIYCSKACSLGEDVQASDSSDSAFQSARSRESRRSVKMGKSSRSADQCRQSLLFSPASNYKFPGLSGNADDTLSKRLSQL--------NFADNHFWRNREDQEAPED-HEEWAEHDDYMTQLLLKFGEHGMFQDTRTDLSIWT------DSELKN--KTGSGGNS-SLASKKYKADMYWTQSQDGLGDSAYGSHPGPASSRKLQDLDLEHG-ASFKHEDNKQWFNDSLECITDQLKEADLNIRDSMDSLALSNITGASVDGDIKDKPLLFSLQKF--SDLDR--CENTSNMGTLNSSMKSLTSDLDRTQVIEEQQEQGVPS---------------PEVHPKPPRLPVLRRSKSQSKTQ----QVKFSDDVIDNGRYDELKVRQPPMSERTRRRAFQFDEQDHQ----RPR--HHHRRRRSRMSRSDNALHLAPK-----EEKPRVCFKD----------DRRKHGLGHNGAQYGDGLRT------------ERFTRLY----EDDWCSTCSSSSSESEEEGFFLGQPIPQPRQPRYQYYASDEAA---------FGTR-TKSKQKRGRKGKNCIIS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F2Z4V3-1", "uniprot_id": "F2Z4V3_DANRE", "id": "F2Z4V3-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHYAKCPHPMSLETTSGIWPITRAPDMDSRGAKAFGFQRSSTSDDDSGCALEEYTWVPPGLRAEQVQIYFSCLPEEKVPYVNSPGEKHRIRQLLYQLPPHDNEIRYCQSLSDEERRELHMFSMQRKKEALGRGTPKLLPRALQHN-CEHCKENINGGEMAVFASRAG-PGPCWHPACFTCYTCHELLVDLIYFYHNGNIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFSCFECETILGGQRYIMKDGRPFCCGCFESLYAEYCEACGENIGVDHAQMTYEGVHWHATDKCFCCAQCKTSLLGCPFLPKDGRIYCSKDCSLGEDVQASDSSDSAFQSARSRESRRSIRMGKSSRPTEQCQQTKLYS-ATDYRTSSLCGDNTETMCHQLERIN--------FTEDNYWRERDEQEAPEDSVEDWAEHEDYMTQLLLKFGDRGVIHAE----DSRAAEPWMVKDTETNRTKPEIKMSGHNLASKKHHTDMYWAQSQDGLGDSAYGSHPGPASARKIQELEMDQGTVPGFWSEPRQWYEDSLECITSELRKADHNIGDSMDSLALSNITGASVDGDSKDRQTIYSLQNMKDQEREIEECDNISNVGTLNSSMLHRSANSLRSLNSELGHEETLGQGAREDDEEDRIPPYFGAEPPSPLNLPVLRRTKSQSQPQSRSQQVKFSDDVLEKGYYGALGLRQPPMSERTRRRTFHIEEEAAAAAERRPANRHHHKRRHSRKTRSENALHLPSKNRGKLHVVPQVISSNMPE-------PRNGILLNHSAHSQHPYRQTTSDFPQQGMVRLDQFQDFCDDDEEDDWCSTCSSSSSESEEEGFFLGQPIPKPRSQSFHYYTEDYPTRVTALTPP-FGSR-TKLK-KKGHKGKNCIIS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z6W3-1", "uniprot_id": "PRIC1_DROME", "id": "A1Z6W3-1", "name": "Protein prickle", "aln": "MSSLSTGGGAGGSSGGPGGADAAAAPAAGQATVTATGNMEPAMVPRTANLLACKQWWRVCFLYGDQQKYYRQLYSKAAAQRLADANQEPDNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKGGATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVPPLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATRLG-PNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQSQQ--------MEAAGGLVDQSKSYAASD--SDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQP--------HFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDR-SLNTPMSTQSASHAPPHPVSILSGASSSS-------------------------PMSGEPAKKKGVR----FEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGR----------HGHGHSSRRRRRRKSSSSSSHHRSGSGHRSHSTTRADTYAP------AQPLSSSYQGPPSVLQAANLVHESPSRQQREREREREREESE-ESDVCSTCSSSSSSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYD---------RKRKPSELGGDKDKNCIIS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .. :. **.* ************:*******.:*: :**: :*::**********: *::***:********:***:**::**::**::** ***::*****. : * : *: * :. *::** .:* . .. .*:*:**.* .* *********:::*.::******* ******:*****:********** ***:**.* **: ********::*:*:* **::::****: *.: ****:.**:::* *****: **.* *: **** .***: * **** ** ** .****.:.: :: : ::* ::. .: . * . . : : ::. : : .. :..* .: . .* : *: : . . : : .:* :. .. *:*:.::* : : * *: : :: ::. .. : : * . .. : : .. : .. .: :**:.* ::. . *: .. .:. : :.* : . *. . .** * * . : * * : * * ..: . . : : :. . : :.. ** .*:***.**: : * : *. : . * * . * :.******", "identical_positions": 226, "similar_positions": 205, "identity": "16.41%" }, { "cls_id": "homologset.agr.HGNC:17020", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B2RYC8-1", "uniprot_id": "B2RYC8_RAT", "id": "B2RYC8-1", "name": "Interleukin-1 receptor-associated kinase 3", "aln": "----------------MAGPCG-ARGTLSPHSLLFDLPPALLGELCTILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVHQGKSGTRELLWSWA-QKNKTIGDLLQVLHEMGHQRAIHLIMNYG-------------------VNWTPPVQTHHELRFPNLPPNSKPVCRESDPGPLELANVTVDNVLVPEHNERGVVLHKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVEIRNQTYAVKLFKQE--KTMQLKKHWKRFLSELEVLLLFNHPHILELAAYFTEMEKLCLVYPYMSNGTLFDRLQCTNGT---TPLSWHVRISVLIGIAKAIQCLHNTRPCAVICGNISSANILLDDQFQPKLTDFAAAHFRPHLEQQSSTINMTGSGRKHLWYMPEEYIRQGRLTIKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELVEKRG-LDSCLSFLDRKIPP---CPRNFSAKLFSLAGQCVATRAKLRPTMDEVLNTLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNYPVPPKEALRTDRVTQKT-PFECSQSEVTFLGLDRNKGNRGSEAACNMPSSSCE-------------ECWCPELAEASQ--------------DLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4B2-1", "uniprot_id": "IRAK3_MOUSE", "id": "Q8K4B2-1", "name": "Interleukin-1 receptor-associated kinase 3", "aln": "----------------MAGRCG-ARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWA-QKNKTIGDLLEVLQDMGHQRAIHLIINYG-------------------VSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKG-TLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQE--KKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGT---TPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRG-LDSCLSFLDRKIPP---CPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKT-PFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHE-------------ECWSPELVAPSQ--------------DLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y616-1", "uniprot_id": "IRAK3_HUMAN", "id": "Q9Y616-1", "name": "Interleukin-1 receptor-associated kinase 3", "aln": "----------------MAGNCG-ARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWA-QKNKTIGDLLQVLQEMGHRRAIHLITNYG-------------------AVLSPSEKSYQEGGFPNILFK-------------ETANVTVDNVLIPEHNEKG-ILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQE--KKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDT---APLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRG-LDSCLSFLDKKVPP---CPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKT-PFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE-------------ESWFPKYIVPSQ--------------DLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0UYS2-1", "uniprot_id": "B0UYS2_DANRE", "id": "B0UYS2-1", "name": "", "aln": "-------MKHPNIITFTPGSTRNMSGNTEPSTLLFDVPPVLMESFCRLMDSGVDGLGWRTLASRILSSQLEVRCIEMYAVAGKSPTKELMWSWA-QRNKTVEDLLKVLDEMGHARARSLFQSQD-------------------SCVLKSSSPPH---YPTYLRS-------------TGKSCQVSDLHAESVSVEG-EKQKCFITYFDVIEGTRHFHQDLKIGGSGFAEVYCGRWGNRSFAVKVFKQE--NKTDWKALWEKFTKEIEVLQLNQHPNILELWGSFSDSDRFCLVYPFLQNGSLFHRLHEHVD----KPLSWQERLNIIKGTAKAVHHLHTSQPCTVICGNITSSNILLDENMQPKLCDFGLARLRPHSVDQSCTIVMNTALHSNLGYLPEEYIRDGKLSVKLDVYSLGVVILETCTGQKVKQESSKNLFLRDVLHSEVEEKGCVDACLRFLDLKFEH---WPPAVALCLLRLGLECTGSKMRVRPDMEMVLQRLIPLHPLPAFSEDQPHTLDDTIPPQ----RPYKSFPIEDDEMHS-----QLEELHSPRVSKPADPCECSQSEVTFLSNEDRSFLRDCHQESDQRVSSSESVHSDSAARLDLYGSWPVECSCSTETEAQACADCCANGFSQSVVYVTIDDDNALPAPNDARNPAKEKMKNKIHLYNQGLIKTEELLSLQSE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q05652-1", "uniprot_id": "KPEL_DROME", "id": "Q05652-1", "name": "Serine/threonine-protein kinase pelle", "aln": "MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQLCAHLDALD---VWQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFG---TKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWR--QNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPFVTD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . : :* : .:* :*: *: ** : :*. *. *:* :.*:: *. * *:*: *: ::..: .* *: . . . : :*. . . . * : .: :.* : * :* . : :** : *:*::: . : : :: .*:: * .* :** * . . : **:* : .*:* **: .*.*: *:.: * ::.: **. : .:* *.:..:*****: :***: **. .: .: . : . *:* *: . :*: ****:*:*::*. ** :* .:: :::* :: : : :*: :. .. : . .*.. : ** *: **. : . . ", "identical_positions": 81, "similar_positions": 140, "identity": "11.71%" }, { "cls_id": "homologset.agr.HGNC:17021", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80Z10-1", "uniprot_id": "ASTN2_MOUSE", "id": "Q80Z10-1", "name": "Astrotactin-2", "aln": "MAAAGARRSPGRGLGLRGRPRLGFHPGPPPPPPPPLLLLFLLLLPPPPLLAGATAAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARTGAAAGAGAGTGAGAG--AAAAAASAASPGSAGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSSRLQTHNSVIGVPIRETPILDDYDYEEEEEPPRRANHVSREDEFGSQMTHALDSLGRPGEEKVEFEKKAAAEATQETVESLMQKFKESFRANTPVEIGQLQPASRSSTSAGKRKRRNKSRGGISFGRTKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGNQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPDTGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDTTSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLSAGFTNVLKILTKESSRDELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKNALMSSYWCSGKGDVIDDWCRCDLSAFDASGLPNCSPLPQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQTAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVDTIPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGETKGR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2JYU3-1", "uniprot_id": "A0A0G2JYU3_RAT", "id": "A0A0G2JYU3-1", "name": "Astrotactin-2", "aln": "MAAAGARRSPGPGLGLRGRPRLRFHPGPPPPPPLPLLLLFLLLLPPPPLLAGATAAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGAAAGAGAGTGAGAGASAAAAAAAAASPGSAGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQLHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSTRLQAHNSVIGVPIRETPILDDYDYEEEEDPPRRANHVSREDEFDSQMTHALDSLGRPGEEKVEFEKK----------------------------------------------------GGISFGRTKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGNQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCIRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTMPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCDGPKCLKSDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLSAGFTNVLKILTKESSRDELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKNALMSSYWCSGKGDVIDDWCRCDLSAFDASGLPNCSPLPQPVLRLSPTVEPSSTVVSLEWIDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQTAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVDTIPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGETKGR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75129-1", "uniprot_id": "ASTN2_HUMAN", "id": "O75129-1", "name": "Astrotactin-2", "aln": "MAAAGARLSPGPGSGLRGRPRLCFHPGPP--PLLPLLLLFLLLLPPPPLLAGATAAAS-REPDSPCRLKTVTVSTLPALRESDIGWSGARAGAGAGTGAG-----------AAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSSRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFRANTPIEIG-QLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGESKGR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******* *** * ******** ****** * ***********************: *******************************:**.**:*** ***:******.*********************************************************************************************:********************************************************************:***:******************* **:*:**************.**:**:*****:******:**** *******:*******************************************************.***************************************************************************:********************:*************************************************************************************************************************************************************************:*****:*******************************:******.************************************************************************************************************:****************:****************************************************************************************************************************************.****************************.******** *********************:*********************************************************************************************************************************** **********************************************************************:*:******************************************:***", "identical_positions": 1247, "similar_positions": 32, "identity": "92.1%" }, { "cls_id": "homologset.agr.HGNC:17022", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LS35-1", "uniprot_id": "F1LS35_RAT", "id": "F1LS35-1", "name": "Hermansky-Pudlak syndrome 5 protein homolog", "aln": "MTSVPVIP-EAYSHVLAEFESLDPLLTALRLDSSRLKCSSIAVSRKWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIACCSHDDDYVAVATSQGLVVVWELNQERRGKPERIHVSSEHKGRKVTALCWDTAVLRVFVGDHVGKVSAIKLNTLKQAKAAAAFVMFPVQTIITVDSCVVQLDYLDGRLLVSSLTRTFLCDTEREKFWKIGNKEREGEFGACFFPGRCAGSQ-------QPLIYCARPGSRIWEVSFDGEVLSTHQFKKLLSMPPLPVITASS-----EPQYDHAVGSSQSLSFPKLLHFSEHCVLTWTEKGIYIFIPQNVQVLLWS-EVKDIQDVAVYKNELFCLHFNGKISHLSLLSVERCVERLLRRGLWDLAARTCCLFQNSIITSRGRKTLSTDKLEHLKSQLDLTACSELISQLEEVIFKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTFSEDERLKEFASHQEEEQPEQGCCANRNGDSVSHSPMMSEIDKGEAFLPFNIPLPFRSPSPLLSLQAVKDSVSSFVRKTTEKIGTLHASPELKETSEPRDADQVHEEEVSAVTCPLEEDTEE-KEIHQPP-EEDRLQGLRAATAEAVTKLLDPLVLFEPKLLRAVLHEWLSQLEKTFAMKGFAAISNTSSLPEKSNLDTHLLGESEKRVLCEESGEERRVTLGTEEPGGQTTCDSVSSLSEPSADSFQVCPPYAIANSLQKDLVELTTLCLELNVLTSAVESDSRHMDCALQQLSPETLACRFLKKYFFLLDLKRAKESVKLSH-YSPCVWDTFVEGLKEMASSTPAYMEMGERDLPTGLQLLDGSVPSHSPLLIAFAARLYDRFGEPALRALIKFYPSISPSDIAQLCRRHPAQFLAYLDSLVKSRPEDQWPSFLEFLLQPESLRLEWLLLAVSHDAPPSTSTVDDEGHPRPHSHLLSWGYSQLILLLIKLPADFATKEKMTDICRSYGFWPGYLTLCLELERRREAFTNIVYLNDVSLMEGDNGWIPETLEEWKLLLHLLQNK---------NTRPAPQESLNGSLSDG-------------PTPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIAERRQRALIQGMLEKCDRFLWSQQA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59438-1", "uniprot_id": "HPS5_MOUSE", "id": "P59438-1", "name": "BLOC-2 complex member HPS5", "aln": "MTFVPVIP-EAYSHVLAEFESLDPLLTALRLDSSRLRCTSIAVSRKWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIACCSHDDDYVAVATSQGLVVVWELNQERRGKPERIHVSSEHKGRKVTALCWDTAVLRVFVGDHVGKVSAIKLNTLKQAKAAAAFVMFPVQTVLTVDSCVVQLDYLDGRLLVSSLTRSFLCDTEREKFWKIGNKERHGEYGACFFPGRCAGGQ-------QPVIYCARPGSRMWEVNFDGEVLSTHQFKKLLSMPPLPVITARS-----EPQYDHTVGSSQSLAFPKLLHLSEHCVLTWTEKGIYIFIPQNVQVLLWS-EVKDIQDVAVYKNELFCLHFNGKISHLSLLSVERCVERLLRRGLWDLAARTCCLFQNSIITSRARKTLTADKLEHLKSQLDLTACSELISQLDDLILRFEPLESACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTFSEDERLKEFASHQEEEQPEQGCGANRNEESASHSPVMSEVDKSEAFLPFSIALPFRSPSPLVSLQAVKDSVSSFVRKTTEKIGTLHGSPELKEPFESKDADRAHEEEVSAVTCPLEEDTEE-KEIHQPP-KEDRLQELTAATAEAMTKLLDPLVLFEPKVLRMVLLEWLSQLEKTFAMKDFPGISNTSSPTVKSNLGAHLLGETEKRVLDEESGEGRRVSLVTEEAGGQITCDPVSNLSEPSADRFRVCSPYAITNSLQRDLAELTTLCLELNVLTSAMESVGGHVDRASQQLSPEILACRFLKKYFFLLDLKRAKESIKLTY-DSPCVWDTFVEGLKEMARSNPAYTELEEGDLPTGLQLLDGSVPSDSPLLIAFATRLYDRFGESALRACIKFYPSISPSDIAQLCRHHPAQFLAYLDSLVKSRPEDQWPSFLEFLLQPESLRLEWLLLAVSHDAPPSTSTVDDEGHPRPHSHLLSWGYSQLILLLIKLPADFTTKEKMTDICRSYGFWPGYLTLCLELERRREAFTNIVYLNDISLMEGDNGWIPETLEEWKLLLHLLQTK---------STRPAPQESLNGSLSDG-------------PAPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIAERRQRALIQGMLEKCDRFLWSQQA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPZ3-1", "uniprot_id": "HPS5_HUMAN", "id": "Q9UPZ3-1", "name": "BLOC-2 complex member HPS5", "aln": "MAFVPVIP-ESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQ-------QPLIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRS-----EPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLWS-EVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSK---------STRPAPQESLNGSLSDG-------------PSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F6NLH0-1", "uniprot_id": "F6NLH0_DANRE", "id": "F6NLH0-1", "name": "Hermansky-Pudlak syndrome 5 protein homolog", "aln": "--MIPVVPVESCTHVLAEFDCLDPLLSALRLDSGRIKCTCLSVSRKWLALGTSAGGLHLIQRDGWKQKLILTHKEGSITQVSCCPHDEDFIAVATSQGLVVVWELHLERRGRPERASVSWEHRGVTVTSLCWDTVALRVFAGDMGGKVSCVRAGSSKLGKGS-AFVIFPVQTVTTVDSRVVQLGYTDGHLVISSLSRCYLCDTEREKFWRVGNKERDGEFGACFLTQGLAGQRGQLVGCPAPLLFCARPGSRIWEASFSGEVLSTHQFKQLLAVPPLPLVSCKN-----EPHFNPTQTNPQSLAFPRLLQFGDQNLLTWTDSAIYIFTPHSGQVLLWT-EVKDVLEISVFRNDLFCLHGDGHLSHMSLVSPDRCVERLMKRENWTIAATVCCMFQHAITTSKARKSLSIDRLEHLKAQLNSTSQQQLIGQLEEVISKLEPLDSACSSRRSSISSHESFNVLDCGIYRVIS-RRGSQSDDDASSLANQSMLEEERLKEFSFTEEEQVDND------------SASVRGEGDRSDLGLQF-LPLPFRSKPPRVALQAVRDSVSSFMKKTTEKINTLQMNADLWPRPDLREG---VQGEVASTASPISEESEQELNTEESS-SESELLELRAATKKAISQIQDPMVLLDPLCLSDVLQEWAPVLERALGPEDQILPVETTNPEEKTLEEEELVS-SMSCCVVVQPEISTSPAADPDESATHTEEEDFRESTPCSIAPVRAQFPPLANHVELIQLFSPKPLPPDLQADLSLLACL--YLEMGCPGRGGMESVCVFLRRFFFLLDQERVRRMCMLRYRENREVLKAYIAGMLEFTQASKVVEVIQKGDLLKSLRSLRELQPWNAPLLLSHLYRLYEKHGEVAVRAYPQFYPTILPSDIMAMA--LPSHFLPYLDNLVQSRAEQQRLSFLGSLLQPETLRQDWLELALSHDAPQREDTLTHDGQPRWHSHFFSWGYGRLLSLLIRLPADLASKQKMLDMCKAHGYWMGYLYLCRELQRRAEAFSAICRLDDMTLLEGDDGIVPQSLDEWVLLLQLSQQISASDESSLTSTKNSNGSCLDDANSNGDCSSGLSNGSTDWSIQVSPENIILRLVRVFGPDRALTALQEHGIPVDHSSRSTLVCDLLRMAEKRQRALIQSMLERCDRFLWSQHA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VHN9-1", "uniprot_id": "HPS5_DROME", "id": "Q9VHN9-1", "name": "BLOC-2 complex member HPS5 homolog", "aln": "---------MADAYCLTNFIDFSLSLSLPLKHHNRIKYTCFDISDSYIIFGASSGSLYLFNRNG-KFLLLIPNKHGAITSLSISAN-SKYVAFATQRSLICVYAVNLSAQATPQVIFTHLDQS-VQVTCIHWTQDEKQFYYGDSRGQVSLVLLSS---FIGHSLLFNMTVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPRDGAFGACFFVSPQESLQ-------PSRIYCARPGSRVWEVDFEGEVIQTHQFKTALATAPARIQRPGSGTDELDANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGSEIFVFTQSGALYSVQLQTLQSHAVSLIQQS----KLLPCANLLRQHVRYFADKAREDYELKQLNPLKQLLIERQEYELLNDISVIFDAITQCTGSALDTHSSGGSSATTER----SLSGGSSSRAPPKGVYVLENAFCDN-----------------------------------------------LKQPLKTG-------HFKDALLTVTGKFGKNIIKYKFN-------------------------IFAEEQQQ------------------------------------------LVRELIPASERSLPFKDIKARYESGSEDQE-----------EEIVRRCKKPAPQVPHISPEEK-----------------------------------------------------------------------------TLYNLYLIAKSAKFSRTQCVDRYRAVFDEYAAGELVNLLEKLAQVMVEHGDTP-----------------------------DQAQRNCYEMYFDYLDPEMIWEVDDATRDHIAAGFVLLNTSQN------------AEIVKCEHCSFPLRFDT--------------------SCQYHELGAVLLRYFWSRGEQLKCFDVVQSVPALLDVLAKFYLAEQNLTKVVAIVLNYGLPELLADVGKQLSVSAWGRCFEQFVELQ-----------RGGRLVCANCECISG------------------------VEQEQLGRHFFYNWNCFLNIALDHMSAGDTLALIFKWSSYIPNDAID--REFYSRCLLKG--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: *::* :. *: . .*:: :.: :* .:: :*::.*.* *::::* * *::.::.*:*:.:: . : ..::*.**.:.*: *: :: . :. *: . :: **.: * :.: ** *:** : .: . :. :.*:.: :** :**:. : *::*. :: **:** *.: ::**: *.* :****: . : . ::*******:**..*.***:.***** *: .* : . :.: : ..*.* *.:: ::.:. :*::*: .:*** : *:**: :.: : : .::* : .* : :.* : : . *::: *. : . . *: .*::*:. : : *::: ::.: .. .* .: ** * : :* .*:: .. : .::: :: : *::: .:::: :. * ::* . : . *: :: :: * . *::: :. :: . : . . :* : : * : .: * . : * . . : . * : * * ::: .:: . ..:. *::: : .* :: : :.: *: * * .* *:: . : * *: :: . * ::. . * .:. : .* * . : :: : : . . : .* . :* . . .:.:: . . ::: :. . *: * .* * . ", "identical_positions": 126, "similar_positions": 309, "identity": "10.82%" }, { "cls_id": "homologset.agr.HGNC:17023", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8WU17-1", "uniprot_id": "RN139_HUMAN", "id": "Q8WU17-1", "name": "E3 ubiquitin-protein ligase RNF139", "aln": "---------------------------------MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFCIVLQIF---LRLFGVFASSIVLILSQRS-------------------LFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIG-----------------------YVTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFE-----SGSKIRAFMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNS--------------------NVSNNNGFIPPNE--TPEEAVREAAAESD--------------------------------------RELNEDDSTDCDDDVQRERNGVIQHTG--AAAEEFNDDTD----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7TMV1-1", "uniprot_id": "RN139_MOUSE", "id": "Q7TMV1-1", "name": "E3 ubiquitin-protein ligase RNF139", "aln": "---------------------------------MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIF---LRLLGIVVSSIVLILSQRS-------------------LFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIG-----------------------YVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFE-----SGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNS--------------------NASNNNGFIAPNENPNPEEALREDAAGSD--------------------------------------RELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7KRW1-1", "uniprot_id": "TRC8_DROME", "id": "Q7KRW1-1", "name": "Protein TRC8 homolog", "aln": "MSVRTKVLGLVDVMMRVPPVMVIDEILKMDMGMQSWLYPDKDKASGALATPTEAPAVPSGQDPFTSIKELFSHMTTSAQSVLEQSIEKASEAAKTHGMLSSGFNSLMNELSKDQTLADVLSTTTVKFVLCVFAFLSAACIFMLWTRHLVMVYMFLTSLGLTFLSYWSNVSALALTERSPSMVEDLMSLNTTRLLDSGGVVMSLAPHLMAQWFMGMLFAYIHLGPRFEHVQRSMPIIFASPILLAMLPLPAKVVQHLPVVAVFTPIILTKITLMQSAMEASRTVYNGYQYAMNFVSNFGLSALIENEWQRLNVPNVLRVFWTIRLIQGG----YALATTESDE-----PLDLMTATQKLLVDGCETMTAVLGMTGVISMFCHYIGRGFQWYLLTYDDEEKSLGTVSAVLFYILALQTGLTSLSPDKRFIRLCRNLCLLMTALLHFLHNIVSPILMSLSAARNPSRKRHVRALSVCAFLVVLSVSLLYHLWSQQSISTWLLAVTAFSVEVVVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAFGNSVEFCFGILLFINGAWILIFESAQNATGGGIRAIMMCIHAYFNIWCEARAGWSVFMKRRSAVHKISALPEATPAQLQAFDDVCAICYQEMYS-AKITRCRHFFHGVCLRKWLYVQDRCPLCHEIMMYTDKADENAPEAEPAPAAQAEQPMRIYPRDDANNAAAQRRSPERAPVEASEQAPATSSSSAAATIGAEAVSAIVESAAAVGEARSLVSVASSSSATHRISASGSSDSSYMTASAQSPPPTATSAAAVATAAASNTTHMFRMSQDQQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * :::. * * *. : *. :*. *:** : :: : *:. *.: ::.: * :* * :. *:* : ::: * :.: * .. *..:.**: *: *: * :. *: * . .: : : : *:: : ** :: : : . : : : * :.* . :. * . :: :**. *:*: *:*:..*::***** *: . * * ::. : *: :*::.**:: :****:.*** ..**:* *: :: : ::::: ** *:.***:********:.* *::*:***.**:***:**:***:*.:..*:******:: .* :**. .* *.* *.:*.* * * ** : ::.***:*****.**: :**:***:.****::*. :.:*******:*:**: *. :** **:::* ***: ::** :*. *** ***:******: :.: **..**:**:**:**.:*** . ::** ::*******:*: : *:** *.*:**.:*******:** **:**: : *. .:*: : :** . . * ** .: .* *. :.:. ..*:*.. . :. *. *.* .:* ", "identical_positions": 225, "similar_positions": 225, "identity": "27.47%" }, { "cls_id": "homologset.agr.HGNC:17024", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5I0E2-1", "uniprot_id": "PHF11_RAT", "id": "Q5I0E2-1", "name": "PHD finger protein 11", "aln": "MAEETAPPCGPVSTGGSL-----------------SPEKMEKRTCALCPDGHEWSVIY-FAPSANIAAHENCLLYSSGLVECGPHDPRNPARSFAVKSVKKEIWRGRRLKCSLCNKGGATVGCDLSSCRKSYHYVCAKKDHAIPQVDEDLGTYKIFCPEHP------------------------------------PQQEETTERADS-----------------PSVKKT-GKKKSLSSGPPTEPKKMKFSRFKRLMKEEPHGHKDAAVKAPFLKKCLEAGLLT---------ELFEQILEKMDSIHGRFMDETASESDYEGIKTLLFD----------------------CGLFGDILRKFQEVIKSKTCEY--------------------------------------------------EERLNQMKQKLEALADLQENLCSFQECGDLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL--------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5I0J8-1", "uniprot_id": "PH11L_RAT", "id": "Q5I0J8-1", "name": "PHD finger protein 11-like", "aln": "MAQEEPGGSNSVLNGDAN-----------------SDKKMEKWTCALCPEGHDWSVIY-FEPSSNIAAHENCLLYSSGLVECGPHDPRNPARSFAVKSVKKEIWRGRRLKCSFCNNKGATVGCDLQSCPKNYHLHCAKEDRAILQVDEDYGTYKLFCQRHA------------------------------------PGGQEPTQ-------------------------------------------------------------VDAAVKASFLKKCLEAGLLT---------ELFEQIQQKMISIHGRFMDDTASESDYEGIKILLFD----------------------CGLFKDTLIKFEEAIKSKACEC--------------------------------------------------EERLNQMKQQLELLADLQQNLRSFQECGVLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL--------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BVM9-1", "uniprot_id": "PH11A_MOUSE", "id": "Q8BVM9-1", "name": "PHD finger protein 11A", "aln": "MAQEKPGCSNPVPNGDCP-----------------IIEKMEKRTCALCPEGHEWSQIY-FSPSANIVAHENCLLYSSGLVECEAPDLPNTVRNFDVKSVKKEIGRGRRLKCSFCKNKGATMGYDLQSCTKNYHLSCAMEDHAILQVDEDHGTYKLFCQKHA------------------------------------PEGQEPTQ-------------------------------------------------------------RDAAVKAPFLKKCQEAGLLN---------VLLEYILEKMDLIHGRLLNETASESDYEGIETLLFG----------------------CGLFGDTLRKFQEVINSKACEW--------------------------------------------------EERQRLMKQQLEALADLQQNLCSFQENGDLDCSSSTSGSLLPPEDHQVRCQESPEVQAGSGDSL--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A6H5X4-1", "uniprot_id": "PHF11_MOUSE", "id": "A6H5X4-1", "name": "PHD finger protein 11", "aln": "MAQETAPPCGPVSRGDSP-----------------IIEKMEKRTCALCPEGHEWSQIY-FSPSGNIVAHENCLLYSSGLVECETLDLRNTIRNFDVKSVKKEIWRGRRLKCSFCNKGGATVGCDLWFCKKSYHYVCAKKDQAILQVDGNHGTYKLFCPEHS------------------------------------PEQEEATESADD-----------------PSMKKKRGKNKRLSSGPPAQPKTMKCSNAKRHMTEEPHGHTDAAVKSPFLKKCQEAGLLT---------ELFEHILENMDSVHGRLVDETASESDYEGIETLLFD----------------------CGLFKDTLRKFQEVIKSKACEW--------------------------------------------------EERQRQMKQQLEALADLQQSLCSFQENGDLDCSSSTSGSLLPPEDHQVRSQESPEVQAGSGDSL--------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UIL8-1", "uniprot_id": "PHF11_HUMAN", "id": "Q9UIL8-1", "name": "PHD finger protein 11", "aln": "MAQASPPRPERVLGASSPEARPAQEALLLPTGVFQVAEKMEKRTCALCPKDVEYNVLY-FAQSENIAAHENCLLYSSGLVECEDQDPLNPDRSFDVESVKKEIQRGRKLKCKFCHKRGATVGCDLKNCNKNYHFFCAKKDDAVPQSDGVRGIYKLLCQQHAQF----------------------------------PIIAQSAKFSG--------------------VKRKRGRKKPLSGNHVQPPETMKCNTFIRQVKEEHGRHTDATVKVPFLKKCKEAGLLN---------YLLEEILDKVHSIPEKLMDETTSESDYEEIGSALFD----------------------CRLFEDTFVNFQAAIEKKIHAS--------------------------------------------------QQRWQQLKEEIELLQDLKQTLCSFQENRDLMSSSTSISSLSY------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7URD4-1", "uniprot_id": "A0A8N7URD4_DANRE", "id": "A0A8N7URD4-1", "name": "", "aln": "-----------MGSGQSP--------------------STYRIICALCKTSDETETTGPLSSKEDISAHQNCLLFSS-NIYCKNSPTYDDLFGFDLEDVKKEQRRGQKLRCYFCNKTGATVGCEIKRCPRSFHYPCAIKADARAIEDFSTGTYRVYCKSHDPNPIEINDEIDNDVDLVLASVEKHVPAEQHNQSTPDPERTRPSEEVKTPAKASSNGGLTSDQRSCGTADKRRIECDSQEHSPEHKTPTKKKKKRRLEYPDNENPTSADAVMAPEVSAPEESMTVNQPNHSTPLPENTRSCEKLNLSTTGAAADDEDDETDIESVSLSVLNKTHLRHIEESQSVLTYETDPVPCIVILDSGPSLESEISLESCSSRNPSPAHEFVTVPKQEKITPTDRTSPAQTVTPQVPAPNQKRVSDGPSVSPQHPSPTAGLRISAVCTLAQSAIKKEQLSDPPAEVSTSDSQSTVPNCQTRAAKFWTRCNQAGWSEGIFSELMSLLHSLGQRVQSGQASYQDYELAFEALKGSGQLPSIIAQIEKDLEKQEQDLQMKKAALCDAKAALAD", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . . : **** . : . : . :* **:****:** : * : .* ::.**** **::*:* :*:: ***:* :: * :.:* ** : * * * *:: * * * ..:: :* . :. *: :. . . :: .*:* * : ::. * :: * .:: *. : :. .:. : * :. . :: . :: .* ", "identical_positions": 49, "similar_positions": 77, "identity": "8.7%" }, { "cls_id": "homologset.agr.HGNC:17025", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96P44-1", "uniprot_id": "COLA1_HUMAN", "id": "Q96P44-1", "name": "Collagen alpha-1(XXI) chain", "aln": "----MAHYITFLCMVLVLLLQNSVLAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSR---FLTKIAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEESVCPTRIPVAARDERGFDILLGLDVNKKVKKRIQLSPKKIKGYEVTSKVDLSELTSNVFPEGLPPSYVFVSTQRFK---VKKIWDLWRILTIDGRPQIAVTLNGVDKILLFTTTS--VINGSQVVTFANPQVKTLFDEGWHQIRLLVTEQDVTLYIDDQQIENKPLHPVLGILINGQTQIGKYSGKEETVQFDVQKLRIYCDPEQNNRETACEIPGFNGECLNGPSDVGSTPAPCICPPGKPGLQGPKGDPGLPGNPGYPGQPGQDGKPGYQGIAGTPGVPGSPGIQGARGLPGYKGEPGRDGDKGDRGLPGFPGLHGMPGSKGEMGAKGDKGSPGFYGKKGAKGEKGNAGFPGLPGPAGEPGRHGKDGLMGSPGFKGEAGSPGAPGQDGTRGEPGIPGFPGNRGLMGQKGEIGPPGQQGKKGAPGMPGLMGSNGSPGQPGTPGSKGSKGEPGIQGMPGASGLKGEPGATGSPGEPGYMGLPGIQGKKGDKGNQGEKGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGESGVDGLMGPAGPKGQPGDPGPQGPPGLDGKPGREFSEQFIRQVCTDVIRAQLPVLLQS---GRIRNCDHCLSQHGSPGIPGPPGPIGPEGPRGLPGLPGRDGVPGLVGVPGRPGVRGLKGLPGRNGEKGSQGFGYPGEQGPPGPPGPEGPPGISKEGPPGDPGLPGKDGDHGKPGIQGQPGPPGICDPSLCFSVIARRDPFRKGPNY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z2G5-1", "uniprot_id": "A0A8M6Z2G5_DANRE", "id": "A0A8M6Z2G5-1", "name": "Collagen alpha-1(XXI) chain", "aln": "MGCKMRSMHFVFWCLYFMLLHLFCTAQDEDMRLSCRTAPSDLVFILDGSWSVDDINFEIVKKWLVNITMSFNIGQKFTQVGVVQYSDDPFLHIPLGKHFSSSDLIKAMESIEYMGGNTNTGRAIKFANDKLFALSERGPNGIAKIAVVLTDGKSQDEVLAAAEAARKKGIILFAIGVGSETEEAQLRAIANKPSSTYVFSVKDYKAIAKIREVIRQKLCEETVCPAKIAINSRDEKGFDILLHLNLAKKAKK-TQGSFYGSKAYQVTSRDDLSESTRMLFPGGLPPSYVFVATLKYKGSVAIEEWDLWRIQTKDEKPQMAVSLNGLDRTVMFTTTTSKTPSGTQTVVFTKSPAKKLFDEKWHQLRLLVTEEDVTLYVDDLEIETLALEPPDGIFINGKTQVGKYVSKETTVPFEVQKLRIYCDPEQNNRETACEIP---GVCANGPGDIDPTPEPCICPPGPPGTPGMTGERGKMGDPGQPGPAGADGKPGVPGFRGSPGIQGSPGIEGQRGADGHKGEKGSPGEAGDRGIPGLPGPPGKTGEKGSAGNQGIQGPPGKDGQTGEKGSRGLAGPPGYPGEPGAPGRDGKDGAPGAIGLKGDPGPPGIPGLDGREGHPGMPGIPGNDGQRGIKGEAGLSGSKGAKGIPGDAGEMGLPGMTGSSGQPGPKGNKGESGESGQAGPPGPEGKPGADGPSGQPGHPGMPGSLGMKGQRGDTGERGADGMKGERGDSGRPGGHGLPGAAGKKGEKGTAGEPGQSGLNGHQGLPGQRGQTGPSGPRGQSGEIGHPGPPGPEGRPGREMSEQHIQQICRDILRSEIPALLLSSQHSQHRSCEHCYTRVGPPGPVGTPG---PHGPRGFPGLSGSNGLQGQRGLPGRPGVPGMKGDPGEKGDKGSQGRSVIGDPGLPGPPGPTGPAGVGKPGQAGKPGSPGHEGKEGKRGQSGEPGQPGVCHPAMCYGAMIRRDPFSKGPNY", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .: : .:**: *:* ::* ******:*********:**. ************* .*:** ** ********* *.*.****.: *...* *:*** *:****:**:**:** * *** *.* ::*************:* **:***.. * ***********:*:************** *:** **:*****::******:***::*.: :***:****** *:: **.** * * *.*:***: **** * :** *********:* ::* . : ****** * * :**:**:***:*: ::****: . .*:*.*.*::. .*.**** ***:******:*****:** :**. .*.* **:***:**:*** .** ** *:********************** * * ***.*:..** ******* ** * .*: * *:** ** .* ***** *: *:**: *****:* ** *:*** * *: ****:**:** * .*.**. * :* :*.** *:.* **.:* ** ** ** .* ***.**** *: *:**:.*.** ** ** .*.**:**:*** * * *** * .*.:* ** ** .* ** * .*..* **.**.***.* .* .*..* :*:*** *..*:**: *:** * **::*: **:* :* ***.* .* ** :*: * * ***:* **** * * :* .* * **:**:**.*: * **** :*:****:***.*:*:* *::*:::*.** * .: *.*:** :: *.** *.** *.****:***.* :*: * *:****** *:** **.:*:***** . *: * ****** **.*:.* * .*.** **::*..** * .*:** **:*.*::*:..: ***** *****", "identical_positions": 553, "similar_positions": 213, "identity": "56.89%" }, { "cls_id": "homologset.agr.HGNC:17027", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3U9N9-1", "uniprot_id": "MOT10_MOUSE", "id": "Q3U9N9-1", "name": "Monocarboxylate transporter 10", "aln": "---------------------------------------------------------------------------------------------------------------MVPSQEEP-AAERETNEAQPPGPAPSDDAPLPGPGPSDVSDVAAEK-VEVELT--RSAGS-------------EPPVP-----------------PEGGWG-WLVMLAAMWCNGSVFGIQNAYGVLFVSMLDTFKAKDDDNMAFKTAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVVGAAVGFIGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLISSVK-LFNTLRILCIFMFVLFLAG--FTYRPLVPSTKEKESGGSRSSFFSRRKLSPPKKVFNFALFKETTYAVWAAGIPLALFGYFVPYVHLMNHVKERFQDVNNKEVLFMCIGITSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLMSMMIPLCSAFGALIAVCLAMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPIAGLLHDKLGTYD------------VAFYLAGIPPFVGGVVLCLIPWIHSKKQRKISKNAGGEKMEKMLENQSSLLSGSSGIFKKDSASII-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q91Y77-1", "uniprot_id": "MOT10_RAT", "id": "Q91Y77-1", "name": "Monocarboxylate transporter 10", "aln": "---------------------------------------------------------------------------------------------------------------MVPSQEEPAAAERETNEAQPPGPAPSDDAPLPVPGPSDVSDGSVEK-VEVELT--RSTGNQ------------EPPEP-----------------PEGGWG-WLVMLAAMWCNGSVFGIQNAYGVLFVSMLETFGAKDDDNMAFKAAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVLGAAVGFVGLMSSSFVSSIEPLYFTYGVVFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLTSTVG-LCYTLRILCIFMFVLFLAG--FTYRPLVPSSKEKESEDSRSSFFSRRKLSPPKKIFNFALFKETAYAVWAAGIPLALFGYFVPYVHLMNHVKERFKDVNNKEVLFMCIGVTSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLTSMMIPLCSVFGALIALCLIMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPVAGLLHDKLGSYD------------LAFYLAGIPPFIGGAVLCLIPWIHSKKQREISKNTGGEKMEKMLANQSSLLSSSSGIFKKESDSII-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TF71-1", "uniprot_id": "MOT10_HUMAN", "id": "Q8TF71-1", "name": "Monocarboxylate transporter 10", "aln": "---------------------------------------------------------------------------------------------------------------MVLSQEEP-DSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEK-VEVELAGPATAEPH------------EPPEP-----------------PEGGWG-WLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVG-LFYTLRVLCIFMFVLFLAG--FTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYD------------VAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1L1W9-1", "uniprot_id": "MOT10_DANRE", "id": "A1L1W9-1", "name": "Monocarboxylate transporter 10", "aln": "-----------------------------------------------------------------------------------------------------------------MTEPEPTLEQEPTPEPEPTQEPTPEPTPEPEPTQEPESEPELELKQENGCTKASEQKSP------------EEFEP-----------------PEGGWG-WVVMLASMWCNGSVFGIQNAFGIMFVYLLNEFGSEHDADLRFKTAWVGSLSMGMIFFCSPIVSVFTDLLGCRITAVGGAAVGCVGLLASSFVTSLGPMYFTYGIVFACGCSFAYQPSLVILGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGLLKSVG-LYHTLRVLAIFMFILMLAG--LTYKPLLPKPVSSSKPGSRCPPLSR--------IFNVNIWKSLGYRIWAFGIPAALYGYFVPYVHLMTHVEERFGPEANKEVLLACIGITSGVGRLIFGRVADYVPGVNKVFLQVSSFMVIGVMSMMIPLCHVFGGLIAVCLLMGLFDGCFICIMAPIAFELVGSQNVSQAIGFLLGMMSIPMTVGPPIAGFLRDRLGSYD------------VAFYLAGIPPLIGGAVLCAIPWVEARRKRREAANT-AENTEKMLESRSPPLEDTVCRTE-EPESVI-------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q08268-1", "uniprot_id": "MCH4_YEAST", "id": "Q08268-1", "name": "Probable transporter MCH4", "aln": "--------------------------------------------------------------------------------------------------MLNIPIIANSKRFLFSKDHEAQSTRDHDVELETREGPSSGYNPNFNAADAILKKNSDQVDLDVNKLTNVTSRVL------------NTPEASLIYDDD-------REFPDGGLKAWLVVFGAFMGLVPVFGLINSLGAIESYISKHQLANISS---STISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVG-FQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYIS-------SVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIGKGTVAN------------YNHFIIFNSALMAAGAACYIISRHICVGAKLCKF---------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P53918-1", "uniprot_id": "ESBP6_YEAST", "id": "P53918-1", "name": "Uncharacterized transporter ESBP6", "aln": "MSTHSNDYFSASSGMVSETSSEVSSINSSQPVSFSKASIAAPVPCSDLHSTKSNDASRKLSISRTLTNRLNDIKKAVDDDNLQTEENSADVNKILESRFDVADAIRLQHNESVQSKLNIPVTHTTTAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLMRNRLYPASTKHSGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLELPPDGGYG-WVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGAS--KYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIALLKERNPTPAIGLKSPRAMFEQLKA--------MFSLKVITKPFVVLIALWFMFALFAYNMMVFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFG-RANVTIVLTTLLTIYMFAFWIP-AHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLVCEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMKLTERQAMTNEKLKEWKASEYDTDSADEDWGKLKERKTKYDLLLGPGIKKYFLRMVYPMKV", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. : . ... . . : : . *:** *:* : : ..:* : * . : : .* : : : . : * * .: . : : ..: : .: .. . . .: * : :* :: .:. .: * . : : . . :*:: : .: . : . . .. :*. . * * . * .: : .: . :** : * .* . :* : :: : : :* * * * : . :: . : . : : :. * . : : . : : . . ", "identical_positions": 28, "similar_positions": 112, "identity": "4.08%" }, { "cls_id": "homologset.agr.HGNC:17028", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5RK19-1", "uniprot_id": "SNF8_RAT", "id": "Q5RK19-1", "name": "Vacuolar-sorting protein SNF8", "aln": "MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGK--FAQDVSQDDLIRAIKKLKALGTGFGIIPVG-GTYLIQSVPAELNMDHTVVLQLAE--KNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEVFP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CZ28-1", "uniprot_id": "SNF8_MOUSE", "id": "Q9CZ28-1", "name": "Vacuolar-sorting protein SNF8", "aln": "MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGK--FAQDVSQDDLIRAIKKLKALGTGFGIIPVG-GTYLIQSVPAELNMDHTVVLQLAE--KNGYVTVSEIKTSLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEAFP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96H20-1", "uniprot_id": "SNF8_HUMAN", "id": "Q96H20-1", "name": "Vacuolar-sorting protein SNF8", "aln": "MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGK--FAQDVSQDDLIRAIKKLKALGTGFGIIPVG-GTYLIQSVPAELNMDHTVVLQLAE--KNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5U3V9-1", "uniprot_id": "SNF8_DANRE", "id": "Q5U3V9-1", "name": "Vacuolar-sorting protein SNF8", "aln": "MHRRGVGAGAIAKKKLAEAKYKERGSVLAEDQIAQMSKQLDTFKTHLEEFASKHKQEIRKSSQFRVQFQEMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLDELHHRVLKGRGK--FAQDVSQDDLVRAIKKLKAMGNGFGMIPVG-GTYLVQSVPAELNMDHTVVLQLAE--KKGYVTVSEIRESLKWEKERACHVLDHLLKEGLAWLDSQAAGEPQYWLPALFSELLSQDVTPEEANQMTP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VD72-1", "uniprot_id": "Q9VD72_DROME", "id": "Q9VD72-1", "name": "Vacuolar-sorting protein SNF8", "aln": "MRRR-VGLGAIQQQKLAAEKYKDKGTDLQENQLEQMTKQMEVFRVKLEEFAMKHKEDIRKNSQFRKQFQEMCAAIGVDPLATGKGFWS-VLGMGDFYYELGVQVVEVCLAANHKTGGLMELDDLRRRLIAARGQSSVHQEITKEDILMAAKKLSIFGNGFVVHKLGKGKYIVQSIPGELSMEETNILNAASNTEQGCVTQSQLIKDLGWTDYRAQQSLDKVLGEGLCWIDKQAGDEPAYWFPSLFPGRNAQTTAAT-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12483-1", "uniprot_id": "SNF8_YEAST", "id": "Q12483-1", "name": "Vacuolar-sorting protein SNF8", "aln": "----MKQFGLAAFDELKDGKYNDVNKTILEKQSVELRDQLMVFQERLVEFAKKHNSELQASPEFRSKFMHMCSSIGIDPLSLFD-RDKHLFTVNDFYYEVCLKVIEICRQTKDMNGGVISFQELEKVHFR-------KLNVGLDDLEKSIDMLKSLEC-FEIFQIR-GKKFLRSVPNELTSDQTKILEICS--ILGYSSISLLKANLGWEAVRSKSALDEMVANGLLWIDYQGGAEALYWDPSWITRQL--------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .:* **:: .. : *.* :: .*: *: .* *** **:.::: ..:** :* .**::**:***: . . :: :.*****: ::::*:* :. .**:: :::*.: : :: :*: : . *. : * : : *. :::*:* **. :.* :*: .. * : * : .* * *: *:.:: :** *:* *. *. ** *: :. ", "identical_positions": 59, "similar_positions": 88, "identity": "22.43%" }, { "cls_id": "homologset.agr.HGNC:17029", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZA55-1", "uniprot_id": "D3ZA55_RAT", "id": "D3ZA55-1", "name": "", "aln": "----MEGKGRLAMVEDAVEYHLFLIPDEARDTDGHRESLQKYIEQIMTQFAP---ILVPYIWQNQPFNLKYKP------------------AKGGVPAHMYGMTKFGDNIEDEWFIVYIIKQITKTFPELVARIEDNDGEFLLIEAADFLPKWLDPDNSANRVFFHRGELCIIPVPRKSERIPWLPTTPPTIQQALSIISAHPEAILASESVQAAVDRRISGYP-EKIGASLHRAHCFLPAGIVAVLKQRPRLVSAAVQAFYLRDPIDLRACRVFKTFLPET-RIMASVTFTKCLYAQLVQQKFVPDRRSGYGLPPPSHP--RYRAHELGMKLAHGFEILCSKCSPHFSDSRKSLVTASPLWASFLESLRRNDYFKGLMEGSAQYQERLEMAKNYFQLSIHRPESSLAMSPGEEILTLLETLPFDIAELKTEEADLPPEDDDQWLDLSPDQLDQLLQDAAGRKVSQPGPQKEEQQNCDVGQVSDSMKAFISKVSTHKGAELP---RDPSEAPITFD-----------ADSFLNYFDKILGTKPQESDS-DDQDEDDLECLDSDDDLGLEAQES---ESLKGALGSLK-------------SYMAQMDQELAHTCMGKSFSTRKQLD--PPSQTANDNSDEEDSGAGDCTVEAVDVDLNLVSNILESYSSQAGLAGPASNLLHSMGVRLPDNADHHSSQ------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CS74-1", "uniprot_id": "ECD_MOUSE", "id": "Q9CS74-1", "name": "Protein ecdysoneless homolog", "aln": "----MEGSGKLAMVEDAVEYHLFLIPDKARGTEEHREILQKYIERIMTQFAP---ILVPYIWQNQPFNLKYKP------------------AKGGVPAHMYGMTKFGDNIEDEWFIVYVIKQITKEFPELVARVEDNDGEFLLIEAADFLPKWLDPDNSANRVFFHHGELCIIPVPRKSERIPWLPMTPPTIQQALSIISAHPEAVLASESIQAAVDRRVSGYP-ERVEASLHRAHCFLPAGIVAVLKQQPRLLSAAVQAFYLRDPIDLRACRVFKTFLPET-RIMASVTFTKCLYAQLVQQKFVPDRRSGYGLPPPSHP--QYRAYELGMKLAHGFEILCSKCSPHFSDSRKSLVTASPLWASFLESLKRNDYFKGLMDGSAQYQERLEMAKNYFQLSIHRPESSLAMSPGEEILTVLQTQPFDVAELKTEEADLPPEDDDQWLDLSPDQLDQLLQDAAGRKESQPGPQKEELQNYDVAQVSDSMKAFISKVSSHKGAELP---RDPSEAPITFD-----------ADSFLNYFDKILGAKPQESDSEDDPGEEDVEGVDSDDDVGFEAQES---ESLKGALGSLK-------------SYMARMDQELAHTSMGRSFTTRERLNKDPPSHTANDNSDEEDSGAGDCAVEAVDVDLNLISNILESYSSQAGLAGPASNLLHSMGVRLPDNADHNPQVSQ----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95905-1", "uniprot_id": "ECD_HUMAN", "id": "O95905-1", "name": "Protein ecdysoneless homolog", "aln": "----MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAP---MLVPYIWQNQPFNLKYKP------------------GKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYP-EKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPET-RIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDP--QYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELP---REPSEAPITFD-----------ADSFLNYFDKILGPRPNESDS-DDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLK-------------SYMAQMDQELAHTCISKSFTTRNQVE--PVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1PDM7-1", "uniprot_id": "A0A8M1PDM7_DANRE", "id": "A0A8M1PDM7-1", "name": "", "aln": "----MDILKRPGIPEDAVQYKLFVVAADPSAPE---KSLQQILQDILAEITP---LLVPYIWQNQPFNLTQHP------------------EKGDVPAHLGGVTEFGDNVEDEWFIVYLLKHITHTFTDIAAVVYDNDGQFLLIEAAEHLPKWLDPDSSENRVFLYHGELHIIPMSSSSGEVGFSRDCVPTVRQALEVLHSHTDRCLAKQTIRSALNQRIHGYP-DKIQQNVHRAHCYVPAGIAVVLSRRPDLIAPAVSAFYLRDPVDLQACRTFHTFPPDT-RVMTSVKFTRCLYAQLQQQSFVPDRRSGFSLPARSHP--QYRAHELGMKLAHGFEILCSKNGESSSD-QEPSVSSNPLWRGFLESLKKNGYFKGNLEGSARYKELMTSAESFFRQSVTRTHRPDIHNPGGEVLKVLQSASYSLEDLKKQEANLPPEDSDAWLDISPQELERLLAERGGRGGTGEEVQEEE-SGYSLIAVTQGMKNFINAMSSHEGAEIP---RSCLAEPFRFD-----------PDSVTSALDRLLGAKDDELDSDDFEDEDDDD--DDDDDEAVQSSVPQEQATGAETLDNLR-------------KYMDEMDQELQSTNIGKSFTQNNRSS--NKAEASKSSSSTSASELLEDEIQPLDVDLNLVTNLLESLSSQAGLAGPASNLLQSLGLHIPPDADQP---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W032-1", "uniprot_id": "ECD_DROME", "id": "Q9W032-1", "name": "Protein ecdysoneless", "aln": "MSKIPGSNLEFVREEDFVEYYIFPKIPDNVQDEGALRKLMLQIRNEISAIVREKSLERSYLWHKDEFQLQVRLGGAEERLLNEETNPEEEAELGDLPPHFHGVTHYGDNISDEWFVVYLLTEITRARGDCIARVSDSDGEFLLIEAADALPDWASPETCEQRVYLVGGHLQLLQNSAASS-----QDKPLTMAMAVQRIRMNPTLYRCSQEIQSCIDARLKEYQIAQPHFSIHRQVLELPHSAAQLLKQKPRLLSSAVRAFCERDSLDIKALRTMRYFPPEATRVRTNVRFTRCLYAMLSHQQYLPEKRLGWHLTDPVSEPERYKEQLLGLKLASGLEILATQAKR----VEGQQLEDLPAWRSYLRSLLSKGYFRDNIEGSAEYQELLNKAKVYFRGNQER-FRTASRAGAEILDLLLHPAEAASEELRDEENNLQPSDSDEWLNISAEDLDSMLQDRYGPKKLYKPNGQMNAEEFTKQLAEFLDRQSNYEGIEHRGLEEPELDSDDDEPPPQANGSTGLTAKVKKNPSMRKACQRNSVIQPEEPDSTHVRNFLDFVIPEDNWDSTSEMSDYADEDDMESNLNALSGGGSVFPLDRQIQSYMEQMDRELAQTSVGKSFHGKKKTAP----------QADEDDFDDIEDFEPININVNTLRNMMDSYQSQVGGAGPVSNLFSAMGVGMSAVEDKEQKDISESAV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . ** *:* :* . : . * :. :: :. : .*:*::: *:* : *.:*.*: *:*.:***:.****:**::..**: : * : *.**:*******: **.* .*:.. :**:: *.* :: . * *: *:. : :. ..: :::.:: *: * : .:** :* . . :*.::* *::.** ** **.:*::* *.:: * *:: *: :.* **:**** * :* ::*::* *: *. :*: **:*** *:***.:: . : * * .:*.** :.**:. ::***.*:* : *: :*: . . . : :*.. :*: : :* *.*.* **::*.::*: :* : * : : . . : *.* * * . * : *. . :: : :* ** . . * :.: * : *. * .** .**:** * :.:** .:: . . . . .:::::* : *:::* .**.* ***.***: ::*: :. *: ", "identical_positions": 153, "similar_positions": 200, "identity": "21.73%" }, { "cls_id": "homologset.agr.HGNC:1703", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ALP3-1", "uniprot_id": "A0A8I6ALP3_RAT", "id": "A0A8I6ALP3-1", "name": "", "aln": "MGLRVMQLVSRVPSRLPKPQGAGSFRGAACRCWPAAAATRTWGRARGGDQVTRLLRLGSPRGRRAGKSQARVQEQGARPGGRPGQWRSAPVMSQGLQLLLLGCACSLAPALAMREVTVACSETADLPCTAPWDPQLSY-TVSWAKVSES-------GNERLELPES-----------KQNSSVEAPK------KRPYSLTIQNTTICSAGTYRCALQELGGQRNFSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88324-1", "uniprot_id": "CD83_MOUSE", "id": "O88324-1", "name": "CD83 antigen", "aln": "-------------------------------------------------------------------------------------------MSQGLQLLFLGCACSLAPAMAMREVTVACSETADLPCTAPWDPQLSY-AVSWAKVSES-------GTESVELPES-----------KQNSSFEAPR------RRAYSLTIQNTTICSSGTYRCALQELGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q01151-1", "uniprot_id": "CD83_HUMAN", "id": "Q01151-1", "name": "CD83 antigen", "aln": "-------------------------------------------------------------------------------------------MSRGLQLLLLSCAYSLAP--ATPEVKVACSEDVDLPCTAPWDPQVPY-TVSWVKLLEG-------GEERMETPQEDHLRGQHYHQKGQNGSFDAPN------ERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NEQ7-1", "uniprot_id": "A0A8M1NEQ7_DANRE", "id": "A0A8M1NEQ7-1", "name": "", "aln": "--------------------------------------------------------------------------------------------MRRFSELIVCLVTLVVAEDQLPEIRAIAGEDAVLRCSAKSETGVQYRSVIWYKVDEAEPSQQLTGLVRKRLTEDD----------GKVEKYNGVEREVVLLEDSKNLILSNVTAEDSGIYRCFLSAPLGYQNQRGDIILTVYKPQTVERMEFNKSSLVYLGEIAAIAGLFLGFLFFGISYVYIR----SFNQRGKKLSLLKMPSPGKNLITSNHLICKTLPEVYV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. *:: . :.. *: . ..* . * *:* :. : * :* * *: *. * . .:. : . :. . . . .* : *.* .:* *** *. * :* * ::* * . :. . : ::. ::* :::* .:. :: .:.: * : ::* :.**.*:* . : : ", "identical_positions": 33, "similar_positions": 73, "identity": "10.41%" }, { "cls_id": "homologset.agr.HGNC:17030", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ATM7-1", "uniprot_id": "A0A8I6ATM7_RAT", "id": "A0A8I6ATM7-1", "name": "GPN-loop GTPase", "aln": "MAAPAAPAEPQAS----GAPELPVCLLVLGMAGSGKTTFVQRLTGHLHNKGCPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQN-TFRYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSSWSSFRLLMTAFSLAQTDIIDHSFAVEWMQDFEAFQDALNQE----------TTYVSNLTRSMSLVLDEFYSSLRVVGVSAVVGTGFDELCAQVTSAAEEYEREYRPEYERLKKSLASAQSNEQKEQLERLRKDMGSIAL-----DPGASTDGASPVLDPSDLILTRGTLDEEDEE--ADSDTDDIDHRVTEESREE--PAFQNFMQESIAQHWKRNK-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCE2-1", "uniprot_id": "GPN1_MOUSE", "id": "Q8VCE2-1", "name": "GPN-loop GTPase 1", "aln": "MAAPVAPSEPQAS----RAPQPPVCLLVLGMAGSGKTTFVQRLTGHLHNKGCPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQN-TFRYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVV-MNKTDIIDHSFAVEWMQDFEAFQDALNQE----------TTYVSNLTRSMSLVLDEFYSSLRVVGVSAVVGTGFDELCTQVTSAAEEYEREYRPEYERLKKSLANAQSNQQKEQLERLRKDMGSVAL-----DPEAGKGNASPVLDPSDLILTRGTLDEEDEE--ADSDTDDIDHRVTEESREE--PAFQNFMEESMA-HWKRNK-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HCN4-1", "uniprot_id": "GPN1_HUMAN", "id": "Q9HCN4-1", "name": "GPN-loop GTPase 1", "aln": "MAASAAAAELQAS----GGPRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQN-MSKYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVV-MNKTDIIDHSFAVEWMQDFEAFQDALNQE----------TTYVSNLTRSMSLVLDEFYSSLRVVGVSAVLGTGLDELFVQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDMGSVAL-----DAGTAKDSLSPVLHPSDLILTRGTLDEEDEE--ADSDTDDIDHRVTEESHEE--PAFQNFMQESMAQYWKRNNK------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V3R3-1", "uniprot_id": "Q9V3R3_DROME", "id": "Q9V3R3-1", "name": "GPN-loop GTPase", "aln": "MAEGVESIKLEALSLSEGIRESPVCILVLGMAGSGKTTFTQKLIQHAQEK-FNPYVVNLDPACREVPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTKMAQFAELVRRAGERGHKWCVIDTPGQIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKTRLPFLVA-LNKIDLKDCGFVMDWMTDFEAFQEAQEEE----------HSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLLTKILESVDEYETDYKPVYEK-KRQERLAESATGPKPVDHVEEDGHAVPLGLSLQDPPPHTGNSIFLMAPSLVPESAEIEDEEEME--EDAKGTAEEQNFHSFVQNH--LTAQQSKRDKLQQEQEQAQP------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47122-1", "uniprot_id": "GPN1_YEAST", "id": "P47122-1", "name": "GPN-loop GTPase 1", "aln": "--------------------MSLSTIICIGMAGSGKTTFMQRLNSHLRAEKTPPYVINLDPAVLRVPYGANIDIRDSIKYKKVMENYQLGPNGAIVTSLNLFSTKIDQVIRLVEQKKD-KFQNCIIDTPGQIECFVWSASGAIITESFASSFPTVIAYIVDTPRNSSPTTFMSNMLYACSILYKTKLPMIVV-FNKTDVCKADFAKEWMTDFESFQAAIKEDQDLNGDNGLGSGYMSSLVNSMSLMLEEFYSQLDVVGVSSFTGDGFDEFMQCVDKKVDEYDQYYKQEREKALNLKKKKEEMRKQKSLNGLMKDLGLNEK----SSAAASDNDSIDAISDLEEDANDGLVDRDEDEGVEREYTFPGEERTKGEVNENSAPDLQRRYQEAMQQVGKTASSETAENIAKYIRN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: :********** *:* * : : ***:***** .**: *::****:::*::**::* *****.***:**:*:*:: *. .::.: : : :******** * *****:****.:*: ***:: *::*. *.: *.*********** . :* : . : : *: . .*. :** ***:** * ::: ::*.*..:*** *: **..* . ***: * *: :: : . .:**: *: *: . :. : :: : :* .. . .. : . *.:: * :.. .:. *. .: : : . ", "identical_positions": 115, "similar_positions": 111, "identity": "27.98%" }, { "cls_id": "homologset.agr.HGNC:17031", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q1XHL7-1", "uniprot_id": "GRK7B_DANRE", "id": "Q1XHL7-1", "name": "Rhodopsin kinase grk7-b", "aln": "MSDMGGLKNLVANTDYLKAQ---SLDEK-EIKKRRCSLGLPHLGNCTDVRVSVSKGFEDICEQQPIGRACFRQFLSVSSPEYLAAAELLDELNCWNLA----------------------------------EAEAKEEARLNIINKFCKADSK-SFLAFLTE--------------------------------------------DEAEKCKAVSEKDFE-------------------------------------------EVMMGQVKEATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQVKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGGDLKYHIFHVG-EVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLAVELPNGKTTTQKAGTKGYMAPEILKQEP-YRTSVDWWALGCSIYEMVAGRVPFR---DHKEKVAKEELLRRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLGS------NDDPRKHEFFKS--INFPRLEAGLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGVVPIAWQQEMIDSGLFDELS--------DPNRKESAAGLEDEE--------------------------QQKSKSCTLL--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q49HM9-1", "uniprot_id": "GRK7A_DANRE", "id": "Q49HM9-1", "name": "Rhodopsin kinase grk7a", "aln": "MCDMGGLDNLVANTAYLKAQ---GGDDK-EMKKRRRSLSLPKPEQCASLRTSLDKDFESLCEKQPIGKKLFRQYLSQGGPECTTAAEFLDDLNEWELS----------------------------------ESAARDKARTNIINKFCKEGSK-SSLTFLTG--------------------------------------------DVATKCKAVSDKDFE-------------------------------------------EVMG-QVKTATKEFLKGKPFTEYQASPFFDKFLQWKEYEKQPISEKYFYEFRTLGKGGFGEVCAVQVKNTGQMYACKKLCKKRLKKKHGEKMALLEKKILERVNSLFIVSLAYAYDTKTHLCLVMSLMNGGDLKYHIYNIG-EKGIEMDRIIYYTAQIATGILHLHDMDIVYRDMKPENVLLDSQGQCRLSDLGLAVEIAVGKTISQKAGTGAYMAPEILNETP-YRTSVDWWALGCSIYEMVAGYTPFKGPDAKKEKVEKEEVQRRILNEEPKFEHKNFDAATIDIIKQFLKKKIDERLGCK-----NDDPRKHEWFKS--INFARLEAGLIDPPWVPKPNVVYAKDTGDIAEFSEIKGIEFDAKDDKFFKEFSTGAVSIAWQQEMIDTGLFDELS--------DPNRKESSGGSDDD----------------------------KKSGTCTLL--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8WTQ7-1", "uniprot_id": "GRK7_HUMAN", "id": "Q8WTQ7-1", "name": "Rhodopsin kinase GRK7", "aln": "MVDMGALDNLIANTAYLQARKPSDCDSK-ELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLAT-VPTFRKAATFLEDVQNWELAE---------------------------------EGPTKDSALQGLVATCASAPAPGNPQPFLSQ--------------------------------------------AVATKCQAATTEEER-------------------------------------------VAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVG-TRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFK---DYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREK---SDDPRKHHFFKT--INFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN--------DPNR---PTGCEEGN--------------------------SSKSGVCLLL--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P32866-1", "uniprot_id": "GPRK2_DROME", "id": "P32866-1", "name": "G protein-coupled receptor kinase 2", "aln": "----MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEK-YAFSPDWFSFGCLLYEMIEGQAPFR---MRKEKVKREEVDRRVKEDPEKYSSK-FNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQINAAPEPDKAGCFPFRRKKKQPARTQPIPIPEHLLTTSHSVSSTTVES", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.*::*** **:*: . ..* : :: * * :* * .:: .:. .: : ::****: ** : * :*::: ::: :. :::. . . : . : : **: . . . ** :** :: :* ::.:::*** * **:: * * :*.**********. **: **:******* ***:**: **.*.*:**:**: :.* *:*.****:::* ****:::*.*****:**:::* *:::.* .*:*::: *: ***. .***** ****:*** *: *:********: *: :.** .*****:: : * . **:::** :***: * .**: **** :*:: :* :: *:. * : .: :* :. .:***. .:* * :*:: :*: *****:: **: *.. .***** :* :** ::*:::* .* :*:.:* ** *.*:**:*:::: * **. *: . : .:* . : ", "identical_positions": 190, "similar_positions": 175, "identity": "26.28%" }, { "cls_id": "homologset.agr.HGNC:17032", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F6TUL9-1", "uniprot_id": "F6TUL9_MOUSE", "id": "F6TUL9-1", "name": "", "aln": "MEISSGLLFLGHLIVLTYGHPTLKTPESVTGTWKGDVKIQCIYDPLRGYRQVLVKWLVRHGSDSVTIFLRDSTGDHIQQAKYRGRLKVSHKVPGDVSLQINTLQMDDRNHYTCEVTWQTPDGNQVIRDKIIELRVRKY--NPPRINT----------------------------------------------------------------------------------------------EAPTTLHSSLEATTIMSSTSDLTTNGTGKLEETIAGSGRNLPIFAIIFIISLCCIVAVTIPYILFRCRTFQQEYVYGVSRVFARKTSNSEETTRVTTIAT----DEPDSQALISDYSDDPCLSQEYQITIRS-------------------TMSIPAC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7FEU1-1", "uniprot_id": "F7FEU1_RAT", "id": "F7FEU1-1", "name": "", "aln": "MEISSSLLFLSHLIVLTYGHPVLKTPERVTGTWKGDVKIQCIYNPLTGYREVLVKWLVQRGSDHVTIFLRDYSGDHVQQAKYRGRLKVSHKVPGDVSLQLNNLQMDDRNHYTCEVTWQTPDGDQVRRDKITELRVQKYPYKPPKITT----------------------------------------------------------------------------------------------EALTTMQSSLEATTITSSTSDWTTSVTQTPQGTTTVPGGKLPIFAIILIICFCCIVVVTIAFIMFRRRTFQ-EYVYEVSRMYARQTSNSEETTRVTTIASAYFNNEPDSQALINDYSDDPCLSQEYQITTRS-------------------TMTIPAC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y279-1", "uniprot_id": "VSIG4_HUMAN", "id": "Q9Y279-1", "name": "V-set and immunoglobulin domain-containing protein 4", "aln": "MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * .**:*.** * ***:* *:.** ***.*****:: * *:** ** :*******::*** ******* :***:*****:***:************:..*:****.*************:** **** ****:* . * :.* ** **: .*:**: ..: * **. * : .* .**:****:**.:**:*..*:.:*:: :* * *:** .:* .**::.:* ** **: :*: :** ** * .:***:**:.***** : * ..*", "identical_positions": 156, "similar_positions": 71, "identity": "39.1%" }, { "cls_id": "homologset.agr.HGNC:17034", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z8Q5-1", "uniprot_id": "D3Z8Q5_RAT", "id": "D3Z8Q5-1", "name": "", "aln": "-MGASGSKARG---LWPFASTT---------------GGGGPEAAGAEQSLVRSRA-RAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLD--PPR----IHVDFPVILYEV---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WVF8-1", "uniprot_id": "TUSC2_MOUSE", "id": "Q9WVF8-1", "name": "Tumor suppressor candidate 2", "aln": "-MGASGSKARG---LWPFASTP---------------GGGGPEAAGSEQSLVRSRA-RAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLD--PPR----IHVDFPVILYEV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M1NBI1-1", "uniprot_id": "A0A8M1NBI1_DANRE", "id": "A0A8M1NBI1-1", "name": "", "aln": "-MGGSGSKPKG---VWPFTSSA---------------AGGEAPGEGSEQCLARLRGSKNATPFVFTRRSSLYFDEDGDLAHEFYEETVVTKNGRKKAKLKRIQKNLIPQGIVKLD--HPR----IHVDFPVILCEI---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O75896-1", "uniprot_id": "TUSC2_HUMAN", "id": "O75896-1", "name": "Tumor suppressor candidate 2", "aln": "-MGASGSKARG---LWPFASAA---------------GGGGSEAAGAEQALVRPRG-RAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLD--HPR----IHVDFPVILYEV---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0M0E7-1", "uniprot_id": "A0ABK0M0E7_RAT", "id": "A0ABK0M0E7-1", "name": "", "aln": "MFTDEEWKRKDALIVSTFIQLIREEPTYEPRLAIFCFGVGSPVAEVAKQSLVRSRA-RAVPPFVFTRRGSMFYDEDGDLAHEFYEETIITKNGQKRSNLRDL-KFLSYRLCICFDSTTPRTLSSINLEWSYYPGTHPGL", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . * :. : .* . . * . . ::*.*.* *. : ..*******.*:::**************::****:*:::*: : * * : : :* ** *::::. ", "identical_positions": 41, "similar_positions": 38, "identity": "29.5%" }, { "cls_id": "homologset.agr.HGNC:17035", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AE98-1", "uniprot_id": "D4AE98_RAT", "id": "D4AE98-1", "name": "Exosome complex component RRP43", "aln": "------------------TRVCETVEPLEYYRRFLKENCRPDGRELGEFRTTTVN---------IGSISTAD---GSALVKLGNTTVICGVK----AEFAAPPVDAPDRG----YVVPNVD---------LPPLCSSRFRTGPPGEEAQVTSQFIADVIENSQIIKKEDLCISPGK--------------------------------LAWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKS---------------------YLNVRANPVATSFAVFD---DTLLIVDPTGEEE------HLSTGTLTVVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMKHK----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D753-1", "uniprot_id": "EXOS8_MOUSE", "id": "Q9D753-1", "name": "Exosome complex component RRP43", "aln": "-----------------MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRATTVN---------IGSISTAD---GSALVKLGNTTVICGVK----AEFAAPPVDAPDRG----YVVPNVD---------LPPLCSSRFRTGPPGEEAQVTSQFIADVVDNSQVIKKEDLCISPGK--------------------------------LAWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKS---------------------YLNVRTNPVATSFAVFD---DTLLIVDPTGEEE------HLSTGTLTVVTDEDGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMRHK----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96B26-1", "uniprot_id": "EXOS8_HUMAN", "id": "Q96B26-1", "name": "Exosome complex component RRP43", "aln": "-----------------MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVN---------IGSISTAD---GSALVKLGNTTVICGVK----AEFAAPSTDAPDKG----YVVPNVD---------LPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGK--------------------------------LVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKS---------------------YLNIRTHPVATSFAVFD---DTLLIVDPTGEEE------HLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P25359-1", "uniprot_id": "RRP43_YEAST", "id": "P25359-1", "name": "Exosome complex component RRP43", "aln": "MAESTTLETIEIHPITFPPEVLARISPELSLQRHLSLGIRPCLRKYEEFRDVAIENNTLSRYADAGNIDTKNNILGSNVLKSGKTIVITSITGGIIEETSAAIKDLDDFGEEELFEVTKEEDIIANYASVYPVVEVERGRVGACTDEEMTISQKLHDSILHSRILPKKALKVKAGVRSANEDGTFSVLYPDELEDDTLNETNLKMKRKWSYVLYAKIVVLSRTGPVFDLCWNSLMYALQSVKLPRAFIDERASDLRMTIRTRGRSATIRETYEIICDQTKSVPLMINAKNIAFASNYGIVELDPECQLQNSDNSEEEEVDIDMDKLNTVLIADLDTEAEETSIHSTISILAAPSGNYKQLTLVGGGAKITPEMIKRSLLLSRVRADDLSTRFNI", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :.* :*.*. . ** *: *** .::: *.*.* : ** ::* *:* ** .:. * :*. * * * : *.: : * : .* * *. :* . ** : * : :*::: *: * :..* :***..:: *. * ::* * :*: **:.*:**.. *:*.:: .:.::.:. :* : ..*:.:.:.: : * . ..*** . . .* * :.: .:*.. . : : . :: . * . :::.. : : : ", "identical_positions": 62, "similar_positions": 110, "identity": "15.74%" }, { "cls_id": "homologset.agr.HGNC:17036", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z0K6-1", "uniprot_id": "SCRG1_RAT", "id": "Q9Z0K6-1", "name": "Scrapie-responsive protein 1", "aln": "MMKCVVLVILGLTLLLGTQAMPSSRLSCYRKLLKDRNCHNLPEGRADLKLIDENVQHHFWEGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNSH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88745-1", "uniprot_id": "SCRG1_MOUSE", "id": "O88745-1", "name": "Scrapie-responsive protein 1", "aln": "MMKSVVLVILGLTLLLETQAMPSSRLSCYRKLLKDRNCHNLPEGRADLKLIDANVQHHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75711-1", "uniprot_id": "SCRG1_HUMAN", "id": "O75711-1", "name": "Scrapie-responsive protein 1", "aln": "MKLMVLVFTIGLTLLLGVQAMPANRLSCYRKILKDHNCHNLPEGVADLTQIDVNVQDHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* *::. :****** .****:.*******:***:******** ***. ** ***.***:***********************************.:", "identical_positions": 76, "similar_positions": 14, "identity": "77.55%" }, { "cls_id": "homologset.agr.HGNC:17037", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q811P6-1", "uniprot_id": "TFB1M_RAT", "id": "Q811P6-1", "name": "Dimethyladenosine transferase 1, mitochondrial", "aln": "-----MAASGKLGTFRLPPLPTIREIIKLFGLRAAKQLSQNFLLDLRLTDKIVRKAGSLAD-VYVYEVGPGPGGITRSILNADIAELLVVEKDTRFIPGLQMLSDAAPG---KLRIVHGDVLTYKIEKAFPDNIRRQWEDDPPNVHIIGNLPFSVSTPLIIKWLENISLKNGPFVYGRTKMTLTFQKEVAERLVATTGSKQRSRLSIMAQYLCNVEHLFTIPGKAFVPKPEVDVGVVHLMPLVQPKIKQPFKLVEKVVQNVFQFRRKYCHRGLGMLFPEAQRLESTGRLLQLADIDPTLRPTHLSLMHFKSLCDVYRKMCDEDPQLFAYNFREELKQKKRKGQEKD-GDSESWGF---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8JZM0-1", "uniprot_id": "TFB1M_MOUSE", "id": "Q8JZM0-1", "name": "Dimethyladenosine transferase 1, mitochondrial", "aln": "-----MAASGKLGTFRLPPLPTIREIIKLFGLRAVKQLSQNFLLDLRLTDKIVRKAGSLAD-VYVYEVGPGPGGITRSILNANVAELLVVEKDTRFIPGLQMLSDAAPG---KLRIVHGDVLTYKIEKAFPGNIRRQWEDDPPNVHIIGNLPFSVSTPLIIKWLENISLKDGPFVYGRTKMTLTFQKEVAERLVATTGSKQHSRLSIMAQYLCNVEHLFTIPGKAFVPKPKVDVGVVHLTPLIEPKIKQPFKLVEKVVQNAFQFRRKYCHRGLGMLFPEAQRLESTGRLLQLADIDPTLRPTHLSLMHFKSLCDVYRKMCDEDPQLFTYNFREELKQKKSKGQEKD-GDPESCGF---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WVM0-1", "uniprot_id": "TFB1M_HUMAN", "id": "Q8WVM0-1", "name": "Dimethyladenosine transferase 1, mitochondrial", "aln": "-----MAASGKLSTCRLPPLPTIREIIKLLRLQAAKQLSQNFLLDLRLTDKIVRKAGNLTN-AYVYEVGPGPGGITRSILNADVAELLVVEKDTRFIPGLQMLSDAAPG---KLRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQYLCNVRHIFTIPGQAFVPKPEVDVGVVHFTPLIQPKIEQPFKLVEKVVQNVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISHFKSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P924-1", "uniprot_id": "A0A8M9P924_DANRE", "id": "A0A8M9P924-1", "name": "rRNA adenine N(6)-methyltransferase", "aln": "MYQTGMAATQKLSGCRLPPLPTIGEIIKLYNLKAQKQLSQNFLLDTRLTDKIVRQAGNLNN-AHVCEVGPGPGGLTRSILKAGAADLLVVEKDMRFIPGLQLLSEAAPG---RIRIAQGDILAYKLERRFPANITKTWEDDPPNLHIIGNLPFNVSTPLIIKWLEQMSNRTGIFMFGRTRLTLTFQKEVAERLTASTGSRQRSRLSVMAQYLTTVKSCFTIPGQAFVPKPNVDVGVVHFTPLAQPQIQQPFKLVEKIVKNAFQFRRKHCRRGLGMLFPESQRQELTEELLCSADVDPTLRPTEISISEFRALADAYSKLCNENQGLFDYDFREELKFKHQVKRQSDRSNQTELSDGNP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VTM5-1", "uniprot_id": "TFB1M_DROME", "id": "Q9VTM5-1", "name": "Dimethyladenosine transferase 1, mitochondrial", "aln": "--MAQPSARVLQSGMRLPPMPTIRELVKLYRLQARKQLSQNFLMDERLTDKIVKSAGRIDPRDLVLEVGPGPGGITRSILRRHPQRLLLVEKDPRFGETLQLLKECASPLNIQFDIHYDDILRFNIEQHIPDTSQR--------IHLIGNLPFAISTRLLINWLDDLAARRGAFRRIDTCMTLTFQQEVAERICAPVGGEQRCRLSVMSQVWTEPVMKFTIPGKAFVPKPQVDVGVVKLIPLKRPKTQLPFHLVERVVRHIFSMRQKYCRRGYGTLLPPEDREEVAEKLFQRAEVQDTLRPFELTVEQCLRLAEVYSEHLVTRPEVAAYDYRAPKNVEVL------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* . ****:*** *::** *:* ********:* *******:.** : * ********:*****. **:**** ** **:*.:.*. :: * .*:* :::*: :. . : :*:****** :** *:*:**:::: : * * * :*****:*****: * .*..*:.***:*:* *****:******:******:: ** .*: : **:***::*:: *.:*:*:*:** *:* :* * : .*: *::: **** .::: . *.:.* : : *::* : . ", "identical_positions": 141, "similar_positions": 89, "identity": "39.39%" }, { "cls_id": "homologset.agr.HGNC:17038", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R431-1", "uniprot_id": "MGLL_RAT", "id": "Q8R431-1", "name": "Monoglyceride lipase", "aln": "-------------------------------------------MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGER--MVVSDFQVFVR-DLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAE--RPTHFSGMILISPLILANPESAS-TLKVLAAKLLNFVLPNISLGR-IDSSVLSRNKSEVDLYNSDPLICHAG-------VKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYH-VLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35678-1", "uniprot_id": "MGLL_MOUSE", "id": "O35678-1", "name": "Monoglyceride lipase", "aln": "-------------------------------------------MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGER--MVVSDFQVFVR-DVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAE--RPTYFSGMVLISPLVLANPESAS-TLKVLAAKLLNFVLPNMTLGR-IDSSVLSRNKSEVDLYNSDPLVCRAG-------LKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYH-VLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99685-1", "uniprot_id": "MGLL_HUMAN", "id": "Q99685-1", "name": "Monoglyceride lipase", "aln": "-------------------------------------------MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGER--MVVSDFHVFVR-DVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAE--RPGHFAGMVLISPLVLANPESAT-TFKVLAAKVLNLVLPNLSLGP-IDSSVLSRNKTEVDIYNSDPLICRAG-------LKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYH-VLHKELPEVTNSVFHEINMWVSQRTATAGTASPP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TT74-1", "uniprot_id": "A0AB32TT74_DANRE", "id": "A0AB32TT74-1", "name": "", "aln": "MNEISIMHMLATCLLVAAVSYWYSNELLTALHLFISDSTLSGDMPEPEGTRRSPQGVPYSDLPHIVNADGLHLFCRYWEPDGPPKALVYVAHGAGEHCGGYADIAHSLTQHGILVFAHDHVGHGQSEGER--MELKNFQIYVR-DSLQHIDIMKARYPKLAVFIVGHSMGGAISILTACE--RPQDFTGVVLIGPMVQMSAESAT-PFKVFMAKVLNRLAPKLTLGP-IDPKFVSRDPKQVEAYEKDELNYHGG-------LRVSFGMQMLDATSRIERELPDIRWPFYILHGDADKLCDIRGSRLLYNEAKSTDKKLKVYEEAYH-ALHHDLPETIESVLKEVSTWILERVPAPQTS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P28321-1", "uniprot_id": "MGLL_YEAST", "id": "P28321-1", "name": "Monoglyceride lipase", "aln": "---------------------------------------------MAPYPYKVQTTVPELQYENFDGAKFGYMFWPVQNGTNEVRGRVLLIHGFGEYTKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGRSKGVTDEYHVFNDLEHFVEKNLSECKAKGIPLFMWGHSMGGGICLNYACQGKHKNEISGYIGSGPLIILHPHTMYNKPTQIIAPLLAKFLPRVRIDTGLDLKGITSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENNYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIQDCPSADKELKLYPGARHSIFSLETDKVFNTVFNDMKQWLDKHTTTEAKP---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : :* : :: .*. ::* : . :. : : ** **: : * . *:.*: * * :. * .::::: : : . : : :.:*: ******.*.: *.: : ::* : .*:: ..: . : * :* . *.: :. :* . :: : .* : : * :: . . : *. :::*. * : * :*: : : . * ** **:* * * : : :. ::*::::. *: .: .. ", "identical_positions": 45, "similar_positions": 103, "identity": "12.47%" }, { "cls_id": "homologset.agr.HGNC:17039", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LPC5-1", "uniprot_id": "F1LPC5_RAT", "id": "F1LPC5-1", "name": "", "aln": "MSEH--AAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGG----LGGLDLEPGG---------LELE---EEELSVEMFTNSSIKFELDIEPKVFKPPGG---ADALNDSQDFPFPETPAK------------------AWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTREQCFGDRFSRLLLDEFLGYDDVLMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSP--PLALGPSS---SPAPTGGASGPGSLGAGAS----VSGSDLGWVAETAAIISDASFLSGLSASLLE----RRPAAP-------SAPDSARPDP----------------------------GASLEDAPAPAGS---------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CIV2-1", "uniprot_id": "MBRL_MOUSE", "id": "Q8CIV2-1", "name": "Membralin", "aln": "MSEH--AAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGG----LGGLELEPGG---------LELE---EEELTVEMFTNSSIKFELDIEPKVFKPQSG---ADALNDSQDFPFPETPAK------------------VWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSP--PLALGPSS---SPAPTGGASGPGSLGAGAS----VSGSDLGWVAETAAIISDASFLSGLSASLLE----RRPTAP-------STPDSSRPDP----------------------------GVPLEDAPAPAGS---------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4ZIN3-1", "uniprot_id": "MBRL_HUMAN", "id": "Q4ZIN3-1", "name": "Membralin", "aln": "MSEHVEPAAPGPGPNGGGGG-PAPARGPRTPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSN--------LDMEDEEEEELTMEMFGNSSIKFELDIEPKVFKPPSS---TEALNDSQEFPFPETPTK------------------VWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVAAAASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLE----RRPASP-------LGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPSEVGS---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FCD1-1", "uniprot_id": "E7FCD1_DANRE", "id": "E7FCD1-1", "name": "", "aln": "MSDNQGNVNNNNVPLNNNNN-GGPNR-IRNPPMNQNPLINVRDRLFHALFFKMAVTYARLFPPSFRRIFEFLVLLKALFMLFILAYIHIAFSRSPINCLEHVREKWPRDGILRVEIQRNSSRAPIFLQFYETEG---IQGLVKEPEEDGHENRQPVVPTDAEEEEEMTMDMFDNSTVRFELDIEPRLNPSMSGGVPGSSLNESQDLSFSQTASKGMQPLRETVSEIEMLTRAVWPQEEYIVEYSLEYGFLRLSQATRQRLNIPVMVVTLDPMKDQCFGDGFSRFLLDECLGYDDILMSSVKALAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMTIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQNQQVGQGNQTALQDNLNNNTSTAAPAGQANAAANVNANGQDQQAAQDQPLLETHSGLVVNPSLSINPSGSDLDWMAEIA-IGPDVLSVPNLGDPLLEPGGIQEATSSSAVVTELCGPNTAGENQNGNISTASVPTVNAKGRSCAQGLGPPGGGGGQKESETNSSSSSVTSHTDCRVVESRRGATDWDDKVENKSENSDSHSTPA", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:: . . * ..... .* * * * :* **********************:*****:***:***:*******:**:******.*************::***:*:****:::******::*** : : ** ** : : ***::::** **:::*******:: . .. .:**:**::.*.:*.:* .***:***********************.********** ::***** ***:**** *****:******.************************************.***********************************:************************************* **************.***********************************************************:******** :* *. *** *::***:.:.*.. : . . . . : ..* . .: :*.**.*:** * * .*. :..*. .*** :..::. * . . . :: : .* ", "identical_positions": 385, "similar_positions": 110, "identity": "55.0%" }, { "cls_id": "homologset.agr.HGNC:1704", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K3N2-1", "uniprot_id": "A0A0G2K3N2_RAT", "id": "A0A0G2K3N2-1", "name": "", "aln": "--------MAQHHLWIWLLCLQTWSEAIEREPDCSMVLNGILGESVTLPVDIKDGQKINNIAWTS---KSSVAFVTPKVG--GHELTVTQDIYKGRLEVTNQTYNLIIRNLRMKDAGTYKADINEKNREKTITKIYCLQIYSRLAKPKITKSSITSLNN----------TCNITLTCSVEE---EEKNVVYSWSPSGEESNVLQIFHSPMDQKLTYTCTASNPVSNNSDSVTVQQPCTDSPS-----------FHPYHGVLPGGLAALSLLMLIPVVALLFHLYKRRRGRIVLEAD----------DVSKKIIYS--AVSRNAHLTESRIYDEIPQSTMLSRTEEPVTTIYSSVQLYEKTGKTNMKDERPPKTLCNEIVV------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q18PI6-1", "uniprot_id": "SLAF5_MOUSE", "id": "Q18PI6-1", "name": "SLAM family member 5", "aln": "--------MAQRHLWIWFLCLQTWSEAAGKDADP-MVMNGILGESVTFLLNIQEPKKIDNIAWTS---QSSVAFIKPGVN--KAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEEN-EETITKIYYLHIYRRLKTPKITQSLISSLNN----------TCNITLTCSVEK---EEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPS-----------FHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEAD----------DVSKKTVYA--VVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UIB8-1", "uniprot_id": "SLAF5_HUMAN", "id": "Q9UIB8-1", "name": "SLAM family member 5", "aln": "--------MAQHHLWILLLCLQTWPEAAGKDSEI-FTVNGILGESVTFPVNIQEPRQVKIIAWTS---KTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNS----------TCNVTLTCSVEK---EEKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMG----------FRTHHTGLLSVLAMFFLLVLILSSVFLFRLFKRRQGRIFPEGSCLNTFTKNPYAASKKTIYTYIMASRNTQPAESRIYDEILQSKVLPSKEEPVNTVYSEVQFADKMGKASTQDSKPPGTSSYEIVI------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1RJH2-1", "uniprot_id": "A0A8M1RJH2_DANRE", "id": "A0A8M1RJH2-1", "name": "", "aln": "MKTRKFAKFTSNYIKMTLFCLCMCFLLKGAFGNIKLVHD---GDSVTLQSALTNVQKYERVLWTFGPDSTRIAQINNAINKISVYNEVLNGKFRGKLSLDAQTGSLTIANATSQHAGLY--ELNTVGGNDVLSKQFRVIILAHLPAPVLMRNSSQCSSSSSSSVQYCSVLCSVVNVSAVSLSWYKGNSVLSSISVSDLSISLTLPLEVEYQDRNTYSCVIDNTISNQTTHLDISTLCQPCEVGVSSLNSGNSVPFGDVVLICIGIAVTFVILAAAGMFSIYWRYKKTHQTCQTPVQQVSEVHEGDDMVEMDELKTMSVSVGGSVMLNTGFTKIKSCDVLQWRFGEPNSDVTNPFVVIRRLNEPDFTEYAGHDETFRDRLQLDQQNGYLKISDIRPTDFGIYKLNIARNGRNVISKTFIVKDSSEDIREASETESLLKTEMISDSRV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1NH98-1", "uniprot_id": "A0A8M1NH98_DANRE", "id": "A0A8M1NH98-1", "name": "", "aln": "MSERSVKMLHVK----VLLSLCWWTLVG-VSGESVSVME---GDSVTLNSGLTELMDDDLIEWRFVNENTSIAVVDIMDTRVTVYDSTER--FRNRLKVDHQTASLTITHTTTEHAGVY--EIKYTGKR---TKHFSLTVNTRLPVPVLIFNSSQCSSS----VQYCSVLCSVVNVSAVSLSWYKGNSVLSSISVSDLSISLSLPLEVEYQDNNTYSCVINNTISNQTTHLDISTLCLTSCS--------------EFKAHCCGFTETMIRLVLS------------------------------ALVGMATLAFLVFDIR-----------------------STGSEHKKPILLVL----------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . ::.* : . : *:***: : : . . : * .: :* : . : :: . .* * . :.** * ::: :* : : : :* * : . . .. *.:. ..:*. : :.* . * . . .: .. ::. **:*. .*.:**.: : * :: : : . : .. . . . . ", "identical_positions": 26, "similar_positions": 81, "identity": "5.83%" }, { "cls_id": "homologset.agr.HGNC:17040", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K3X0-1", "uniprot_id": "CASC3_RAT", "id": "Q8K3X0-1", "name": "Protein CASC3", "aln": "MADRRRQR--ASQDTEDEESGASGSDSG-SPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSE-------GEE-----EYSEEENSK--VELKSEANDAADSSAKE-KGEE-----KPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEG--RWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRR-------------------IRKPRFGSPPQRDPNWI--GDRSSKSHRHQGPGGN-LPPRTFINRNAAG--TGRMSTSRNYSRS------GGFK-----------EGRTSFRPVEVGGQHGARSGETLKHEANYRSR-RLEQTPMRDPSP--------------EPDAPLLGS--------PEKEEVASE------------TPAAVPDITPPAPDRPIEKKSYSRARR-TRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPP-AAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPS----------------FLQPRELRGMPNHIHMGA-------GPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGD--------SPAPLPPQGMIVQPEMHLPHP---GLHPHQSPAPLPNPGLYP-PPVSMSPGQPPPQQ------------------------LLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K3W3-1", "uniprot_id": "CASC3_MOUSE", "id": "Q8K3W3-1", "name": "Protein CASC3", "aln": "MADRRRQR--ASQDTEDEESGASGSDSG-SPARGGGSCSGSVGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSE-------GEE-----DYSEEENSK--VELKSEANDAADSSAKE-KGEE-----KPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEG--RWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRR-------------------IRKPRFGSSPQRDPNWI--GDRSSKSHRHQGPGGN-LPPRTFINRNTAG--TGRMSASRNYSRS------GGFK-----------DGRTSFRPVEVAGQHGGRSAETLKHEASYRSR-RLEQTPVRDPSP--------------EPDAPLLGS--------PEKEEVASE------------TPAAVPDITPPAPDRPIEKKSYSRARR-TRTKVGDAVKAAEEVPPPSEGLASTATVPETTP--AAKTGNWEAPVDSTTGGLEQDVAQLNIAEQSWSPSQPS----------------FLQPRELRGVPNHIHMGA-------GPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGD--------SPAPLPPQGMIVQPEMHLPHP---GLHPHQSPGPLPNPGLYP-PPVSMSPGQPPPQQ------------------------LLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O15234-1", "uniprot_id": "CASC3_HUMAN", "id": "O15234-1", "name": "Protein CASC3", "aln": "MADRRRQR--ASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSE-------GEEG----EYSEEENSK--VELKSEANDAVNSSTKEEKGEE-----KPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEG--RWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRR-------------------IRKPRYGSPPQRDPNWN--GERLNKSHRHQGLGGT-LPPRTFINRNAAG--TGRMSAPRNYSRS------GGFK-----------EGRAGFRPVEAGGQHGGRSGETVKHEISYRSR-RLEQTSVRDPSP--------------EADAPVLGS--------PEKEEAASE------------PPAAAPDAAPPPPDRPIEKKSYSRARR-TRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPS----------------FLQPRELRGMPNHIHMGA-------GPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGD--------SPAPLPPQGMLVQPGMNLPHP---GLHPHQTPAPLPNPGLYP-PPVSMSPGQPPPQQ------------------------LLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1ECZ4-1", "uniprot_id": "CASC3_DANRE", "id": "Q1ECZ4-1", "name": "Protein CASC3", "aln": "MADRRRRRRRASQDSEEEDESASGSESG-------RSFSASRKTRGREPEPVES----------PAERVAAKSDDESECVSEDGVG-EAVLSDYDSADLEENGSHTEGGEEEEEAEHFSEEEASRPAAESKPVADAPTEELVEGEERDESVKEVKADEKGNLAGERQSGDGQESTEDPENK-GSKGQK-LDDDEDRKNPAYIPRKGLFFEHDVRGQATEEE-RPKGRNRKLWKDEG--RWEHDKFREEEQAPKSRDELIAFYGYDIRNGTGPSDGRSYR-------------------SRKPRHAGSPSREPRRYREGDKSVRSSWQGPPPGHRNAPQSVTVQSGQP--LAPLSAPKPSGRPSTQPPQRSFQGSRAPSAPHRTEGRGPSKPSLDGAPLRGPRSQPVEGERGPRLRGRSSHAVHADRSPSLVVEDICSEEEEEEGEIPTATTTYTAHHYKTEKERVPSPRKQDSGMVMEGGSAAGQVRELSPPQERQVEKKSYSRARRATRTRPSDLSKQASLDDSSS--AVQQAPVAAKSESWQEQS---EAGTQSGLTGLDQDLARLSLTGQNWAQNPPS----------------YLQA-EMRGIRGSMHMAG-------GPP-QYGNMEDMGVGGGRAKRYSSQRQRPVPEP--APMHIGVMEGHYYEPMTFQGPIYTHGE--------SPAALPPQGMLVQPEMHLPHPTHPGLHPHQSGGPLPNPAIYAAPPVSLSPGQPPPQQ------------------------LLPPPFYPPPGVMTFGNTNYPYPAGGTLPP----MYPNPQAQSQVYGGVTYYDTIQQQAQPKRSPPRRSSNPVTVRPPPPEDQSRKAAEEIRS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KH64-1", "uniprot_id": "A0A0B4KH64_DROME", "id": "A0A0B4KH64-1", "name": "Protein CASC3", "aln": "MAEVEKPTAATPPTDIPQATAAPASEAPVAVTPTADTTVDVEPGTSPTQEPNSN-----------SHPHDSEYDTASDLEGGEDYDDEESASGSASGSGSE--------EES----ETDDEDDEVGSETDDGEGEQAMDRSVADSEAQKK----VDEDRSNPQYIPKRGTFYEHDDRTAETEGEILIEPENGAGQAAAEPNGELNGLAAAGATPTGQTPQISQASKTMRKWQPASGGDRWSHDRFEATEQAPKSRAELLQTYGYDIRNEDAPPRARRRRRYTRGPSKYSRNWEDEQAYLKASNKERKPPRPQDFPALNERKPRGPRTSSSREEKENRRSVAAEGLVPEKQQPLASSSNPHRSQERERERERERERD------REPKNRNFGRMNGGPGRQNGMEFKKNNRGQQLRERERGPDQLDNRN-------------QKPSTPRSNQQQQPQQQPHHQQQPQQQRQ----------PSQPQQSPQTPLSTSNLSQRLQQVQQRNDPSHVGSVQMHSLASQNQAPQQQQQQPLHQEQRNAPKRYSSLRRSQQEASQHLAEQQQQQMQQQLHLQQQQQQQQSQIMIQDPHVLMQIAYQQQELQAQLQTMQLGPPTAAGAVPTPPKPHAPPAAAYPQAQAAPYYVTGTEPVPVPVPQAPYVNPASAAYLPTTPAAVAYAQAGPPVVTQPTPPPAQAPPATQPAQPYQNYNTVGGTTYFVPPAQTTSRPSALPQRRPTNAIPILPPSEKHKVKGGAKEEGISDNIDHIIDNMFVQRPSAFQATGEGATPGGGTKEEAAATPPAAEQNLQPVPATGQEXVQAYAGLPPQQQQRRGQRIAPPPSSGYSMLQPHAGYYRPPPPPH----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: .: :. : .*..*:: : . * . . :: *: . :. : *. *.. .* ** . .:*: . . .: . : . : :: : :.. : * * : :. *. : :. : . :** : :.. ** .* **.**:*. ******* **: ******. * : * : .. * * .:: :. ::. .. :::. *. : : : .. : : : . : * * . * : . * .::. . .. .* :.:: . :* :: .. : . .: : . :. * :: : . * *::. :::. .* : . .:* * .*** * . ::. .. * . . * .** ** .** : . : . ..: *.. * **.:: : *. : ..* . . ... *. : * . : : . : . *** : : .* :. ::* . . .. ", "identical_positions": 82, "similar_positions": 191, "identity": "9.47%" }, { "cls_id": "homologset.agr.HGNC:17041", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P48722-1", "uniprot_id": "HS74L_MOUSE", "id": "P48722-1", "name": "Heat shock 70 kDa protein 4L", "aln": "-MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSTGVKVRYLEEERPFAIEQVTGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKPRNVVFIDMGHSAYQVSVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKSVMDQANLQREDINSIEIVGGATRIPAVKEQVTRFFLKDISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSVTLRWKTSFEEGTGECEVFSKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPY-PDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAAMETEA-PKSEGK-EDVDKMQVDQEEGGHQKCHAEHTPEEEIDHT-GAKAKAPPSDKQDRINQTIKKGKIKSIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKL-GTVYEKFITPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDRLQELKKYGQPIQMKYVEHEERPKALNDLGKKIQLVLKVIEAHRNKDERYDHLDPAEMERVEKYISDSMNWLNSKMNAQNKLSLTQDPVVKVSEIVTKSKELDNFCNPIVYKPKPK----VEAPEDKAKTGSEHNG-PMDGQSGSETSPDPPKGSSQHT-DSGEMEVD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P83581-1", "uniprot_id": "HS74L_RAT", "id": "P83581-1", "name": "Heat shock 70 kDa protein 4L", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSAMLEDTENWLYEE--------------------------------------------------------------------------------------------LSLTQDPVV------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O95757-1", "uniprot_id": "HS74L_HUMAN", "id": "O95757-1", "name": "Heat shock 70 kDa protein 4L", "aln": "-MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVFCKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPY-PDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENK-DNMDKMQVDQEEG-HQKCHAEHTPEEEIDHT-GAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRL-GTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPK----AEVPEDKPKANSEHNG-PMDGQSGTETKSDSTKDSSQHTKSSGEMEVD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "X1WBR5-1", "uniprot_id": "X1WBR5_DANRE", "id": "X1WBR5-1", "name": "", "aln": "-MSVVGIDVGFQNCYIAVARSGGIETIANEYSDRCTPACISLASKNRTIGNAAKSQIITNFKNTVHGFKKFHGRAFDDPFVQGEKSRLPYSLHKLDNGNAGIKVRYLNEDKVFTIEQVTAMLLTKLKETSEHALKKPVVDCVISVPSFFTDVERRSVMDATQIAGLNCLRLINDTTAVALAYGIYKQDLPNPEEKPRNVVFVDIGHSSYQVAIASFNKGKLKMLATAFDPYLGGRNFDEILVEYFCEDFKNRFKLNVKDNPRALLRLYQECEKLKKLMSANSSDLPLNIECFMNDIDVHGKLNRTQFEEMCSQLMMRVEAPLRSVMEQSKLSRDEIYAIEVVGGATRMPAIKERISKFFGKDTSTTLNADEAVARGSALQCAILSPAFKVREFSITDTVPFPITLRWKSPTDESVGECEVYSKNHPAPFSKIITFHKKEPFDLEAFYSCPHDLPY-PDVRIGRFSVQNVVPQPDGDSSKVKVKVRVNVHGIFSVSSASLIEKQ--KGEPEDVQMDTEPTVQNEGRPEEQSKMQVDQEGQGEQPSEEERANNSGIKDG-DKQDQGASSSK--------AKSKVKSVDLPILANTTRQLDRDVLTHFVEYEKKMIIQDKLEKERNDAKNGVEEYVYDLRDKL-CGIYEKYVTEDESNRLTIMLEDTENWLYEEGEDQDKEIYQHKLAELKKYGEPIEERYREHEGRPRAFDELGKKLQLFMKVVDMYRDKDERYEHLSAEDMGVVEKSVNEALGWMNTKMNAQSKLSFAQDPAVKVADIIQKIQELEDVCNPILNRPKPKT---EELVEEGDKSDGAHNG-PTAQQGAD------SKGNQQTKPPSGEMDVD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9MSL3-1", "uniprot_id": "M9MSL3_DROME", "id": "M9MSL3-1", "name": "", "aln": "-MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPY-PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKK----EAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNGQSAAGNDPSMEVE--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32589-1", "uniprot_id": "HSP7F_YEAST", "id": "P32589-1", "name": "Heat shock protein homolog SSE1", "aln": "MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVAFVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKKVLSAN-TNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKFEDIHPYSVSYSWDKQVEDE-DHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQLPPNTPEQIANWEITGVQLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIE---VEEPIPLPEDAPEDAEQEFKKVTKT-------------------------------------------------VKKDDLTIVAHTFG-LDAKKLNELIEKENEMLAQDKLVAETEDRKNTLEEYIYTLRGKL-EEEYAPFASDAEKTKLQGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRGRYLAKEEEKK--------------------------------------------------------QAIRSKQEASQMAAMAEKLAAQR-------------------------KAEAEKKE------------------EKKDTEGDVDMD--", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P32590-1", "uniprot_id": "HSP79_YEAST", "id": "P32590-1", "name": "Heat shock protein homolog SSE2", "aln": "MSTPFGLDLGNNNSVLAVARNRGIDVVVNEVSNRSTPSLVGFGPRNRYLGESGKTKQTSNVKNTVENLKRIIGLKFKDPEFDIENKFFTSKLVQLKNGKVGVEVEFGGKTHVFSATQLTAMFIDKVKHTVQEETKSSITDVCLAVPVWYSEEQRYNIADAARIAGLNPVRIVNDVTAAAVSYGVFKNDLPGPEEKPRIIGLVDIGHSTYTCSIMAFRKGEMKVLGTAYDKHFGGRDFDRAITEHFADQFKDKYKIDIRKNPKAYNRILIAAEKLKKVLSAN-TTAPFSVESVMDDIDVSSQLSREELEELVEPLLKRVTYPITNALAQAKLTVNDIDFVEIIGGTTRIPVLKKSISDVFGKPLSSTLNQDEAVAKGAAFICAIHSPTLRVRPFKFEDIDPYSVSYTWDKQVDDE-DRLEVFPANSSYPSTKLITLHRTGDFSMKAVYTHPSKLPKGTSTTIAKWSFTGVKVPKDQDFIPVKVKLRCDPSGLHIIENAYTTEDIT---VQEPVPLPEDAPEDAEPQFKEVTKT-------------------------------------------------IKKDVLGMTAKTFA-LNPVELNDLIEKENELRNQDKLVAETEDRKNALEEYIYTLRAKL-DDEYSDFASDAEKEKLKNMLATTENWLYGDGDDSTKAKYIAKYEELASLGNIIRGRYLAKEEEKR--------------------------------------------------------QALRANQETSKMNDIAEKLAEQR-------------------------RARAASDD------------------SDDNNDENMDLD--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * *:*** : : : ", "identical_positions": 5, "similar_positions": 5, "identity": "0.59%" }, { "cls_id": "homologset.agr.HGNC:17042", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WV25-1", "uniprot_id": "PUF60_RAT", "id": "Q9WV25-1", "name": "Poly(U)-binding-splicing factor PUF60", "aln": "---------MATATIALQVNGQQGGGSEPAAAAAAAAAAVVAAGDKWKPPQGTESIKMENGQSTGTK--LG--LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTN------LQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAG---------AAVLGTLATPG--LVSPALTLAQPLGA----LPQAVMAAQAPGVITGVTPARP---PIPVTIPSVGVVNPILASPPTLG-----------------------LLEPKK------------------------------EKEEEELFPESERPE---MLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSMASETHKAIQALNGRWFGGRKVVAEVYDQERFDNSDLSA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UEB3-1", "uniprot_id": "PUF60_MOUSE", "id": "Q3UEB3-1", "name": "Poly(U)-binding-splicing factor PUF60", "aln": "---------MATATIALQVNGQQGGGSEPAAAAAAAAAAVVAAGDKWKPPQGTESIKMENGQSTGTK--LG--LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTN------LQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAG---------AAVLGTLATPG--LVSPALTLAQPLGA----LPQAVMAAQAPGVITGVTPARP---PIPVTIPSVGVVNPILASPPTLG-----------------------LLEPKK------------------------------EKEEEELFPESERPE---MLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSMASETHKAIQALNGRWFGGRKVVAEVYDQERFDNSDLSA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UHX1-1", "uniprot_id": "PUF60_HUMAN", "id": "Q9UHX1-1", "name": "Poly(U)-binding-splicing factor PUF60", "aln": "---------MATATIALQVNGQQGGGSEP-----AAAAAVVAAGDKWKPPQGTDSIKMENGQSTAAK--LG--LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTN------LQMAAVTMGFGDPLSPLQSMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAG---------AAVLGTLGTPG--LVSPALTLAQPLGT----LPQAVMAAQAPGVITGVTPARP---PIPVTIPSVGVVNPILASPPTLG-----------------------LLEPKK------------------------------EKEEEELFPESERPE---MLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QZ57-1", "uniprot_id": "F1QZ57_DANRE", "id": "F1QZ57-1", "name": "", "aln": "--------------MAVAVSAVNGG----------------------------EALMMENGQSTASK--LG--LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMPNSLQMASLTMGFGDPLSPLQSVAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTLKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHPDLSDDDIKSVFEAFGRIKSCSLARDPTTGKHKGYGFIEYDKAQSAQDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQMAWNLSQPE--NRTEDFLNCLEAVAGASILGAMTAGTGLSMPQ--LPQAVMAAQAPGVITGVTPARP---AMPV-VPQVGLVNPVLSSPPTLSAAVA------------------AAQEAKK------------------------------EKEEEEALLDGLGQE---MLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVGPEDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEED---AEVIVKIFVEFSAASEMNKAIQALNNRWFGGRKVIAEVYDQERFDNSDLSA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6IQE0-1", "uniprot_id": "PU60B_DANRE", "id": "Q6IQE0-1", "name": "Poly(U)-binding-splicing factor PUF60-B", "aln": "---------------------------------------------------------MENGQGTGSK--LG--LPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTN------LQMAAVTMGFGDPLSSLQSVAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPGSIGQAQPIIEQLAEEARAYNRIYVASIHPDLSDDDIKSVFEAFGKIKSCMLAREPTTGKHKGFGFIEYEKPQSSLDAVSSMNLFDLGGQYLRVGKAVTPPMPLLTPTTPGGLPPAAAVAAAAATAKITAQEAVAG----------TVLSSLASPA-------HILSQQMGL-----PQAVLAAQAPGIITGLSTTKT---VFHL----VGLVNPVLASPPVTAPASMGTPTSAV----------QLHTEVKR------------------------------EEDSRRTAEDHSAPVGNGQDSELERLSVSASAGRQAAIQ-----SKSTVMVLRNMVGPEDIDDDLEGEVMEECGKYGAVNRVIIYQERQGEEDD---AEIIVKIFVEFSDAGEMNKAIQALNNRWFAGRKVVAELYDQDRFNSSDLTA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8T6B9-1", "uniprot_id": "PUF68_DROME", "id": "Q8T6B9-1", "name": "Poly(U)-binding-splicing factor hfp", "aln": "MGSNDRASRSPRSDDQREISDMPATKRTRSDSGKSTDSKIPYLSQPLYDLKQTGDVKFGPGTRSALLGLLGGALPKLSSEQHDLVSKAKKYAMEQSIKMVLMKQTLAHQQQQLAT-----------------------QRTQVQRQQALALMCRVYVGSISFELKEDTIRVAFTPFGPIKSINMSWDPITQKHKGFAFVEYEIPEGAQLALEQMNGALMGGRNIKVGRPSNMPQAQQVIDEVQEEAKSFNRIYVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNLFDLGGQLLRVGRSITPPNALACPTTNSTMPTAAAVAAAAATAKIQALDAVASNAVLGLSQNTPVMAAGAVVTKVGAMPVVSAATSAAALHPALAQAAPALLPPGIFQAPTPVAPSLLGVPAGLQPLQAVVPTLPPPALLATPTLPMTVGGVGVGLVPTVATLAGAEASKGAAAAAALSAAANNAAVTAANLSENIKKAHEKQQEELQKKLMDEGDVQTLQQQENMSIKGQSARQLVMQRLMRPVDSRVIILRNMVGPEDVDETLQEEIQEECSKFGTVSRVIIFNEKQTENEDDDEAEIIVKIFVEFSAGAEAMRGKEALDGRFFGGRRVVAELYDQGIFDQGDLSG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * :. ** ** *:.**:: :.************ **:***:*******:. * .***:***:********* :** ***** **:********:****.:* ***********:**.*********..::**********..: *** :*::: ***:::*******:* ***::********** * * **: .: .***:***** : *: :*::********** ****:::*** .* *:* . :*.************* * * .: . . .**. * .**:: . :.. . . : * * *..*. . * .: *::... . .: *.:*:...:.*: .:* .* *::*****.*:*:*: *: *: ***.*:*:*.****::*:* *::* **:********* ..* :. :**:.*:*.**:*:**:*** *:..**:.", "identical_positions": 248, "similar_positions": 135, "identity": "37.58%" }, { "cls_id": "homologset.agr.HGNC:17043", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LT49-1", "uniprot_id": "A0ABK0LT49_RAT", "id": "A0ABK0LT49-1", "name": "", "aln": "MLPIHPLTRLSPHRLTSQSDLELRLPLRPAPRRSSPSRWGAVRARAAEGGAGGMGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRR--------GTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTSQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMN-------------------KSNMKTD---------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BHK1-1", "uniprot_id": "NIPA1_MOUSE", "id": "Q8BHK1-1", "name": "Magnesium transporter NIPA1", "aln": "-----------------------------------------------------MGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRR--------GTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMN-------------------KSNMKTD---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7RTP0-1", "uniprot_id": "NIPA1_HUMAN", "id": "Q7RTP0-1", "name": "Magnesium transporter NIPA1", "aln": "-----------------------------------------------MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRR--------GTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMN-------------------KSNMKTD---------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PD12-1", "uniprot_id": "M9PD12_DROME", "id": "M9PD12-1", "name": "", "aln": "------------------------------MNSDGEASSLQMPQVTVGGMLPVEANQSPETAPLSMAETVSNTDFYIGVGLAISSCFFIGSSFIIKKKALIRLSRYGEVRASAGGFGYLREWIWWAGLLTMGVGEAANFAAYAFAPASLVTPLGALSVIISAVMASRFLNEKLNLLGKIGCFLCILGSTIIVIHSPKEKEIEDLQLLFDMLLDPVFILYVICIVGSTVFVACFIAPRHGHTNVVVYIFLCSGIGSLTVMSCKALGLAIRQTLNNGGNVFLTWMPWFLILVTVTF-IAIQMNYLNKALDIFNTSIVTPVYYVMFTTLVIAASAILFKEFTHMRFDDILGDVCGFLIVITAVFLLNAFRDIDISLNDVRGLMRPKMQRVSQFDEEVLVTSNTKERRLSYGSSDIFRKAXHKQRYQV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :. :*. . *. * : . :*:*:*: *.:. **:*:::**.::* .* * .** : :**** ::*.**: .** **: .*: ********.* :.:::** :*:****:***:**:*. **.:::*****.:.: * : * :***: *: :: ::: :*** ** **::*** :** :**:** * *.:*** :: *:*. . : :::*..: * :*:.*:****: *::*:. .:***:*****: ******:*:::: : *:** .*** * ..:.*::.*:::::.*.::. .** * ", "identical_positions": 125, "similar_positions": 123, "identity": "29.48%" }, { "cls_id": "homologset.agr.HGNC:17044", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZUV1-1", "uniprot_id": "D3ZUV1_RAT", "id": "D3ZUV1-1", "name": "", "aln": "-----------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGITIKELLA-GKPVLQHPLAWILLLSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVTFRKDEKAVNGNLSNMYEVLNNNEEDLPCGIE-HTGENISRRNGNLTSF--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JJC8-1", "uniprot_id": "NIPA2_MOUSE", "id": "Q9JJC8-1", "name": "Magnesium transporter NIPA2", "aln": "-----------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLA-GKPVLQHPLAWILLFSLVVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSSMYEVLNNNEDDLPCGIE-HTGENISRRNGNLPSF--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N8Q9-1", "uniprot_id": "NIPA2_HUMAN", "id": "Q8N8Q9-1", "name": "Magnesium transporter NIPA2", "aln": "-----------------------------------MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWWAGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFA-GKPVLRHPLAWILLLSLIVCVSTQINYLNRALDIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVSFRKDEKAMNGNLSNMYEVLNNNEESLTCGIEQHTGENVSRRNGNLTAF--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PD12-1", "uniprot_id": "M9PD12_DROME", "id": "M9PD12-1", "name": "", "aln": "MNSDGEASSLQMPQVTVGGMLPVEANQSPETAPLSMAETVSNTDFYIGVGLAISSCFFIGSSFIIKKKALIRLSRYGEVRASAGGFGYLREWIWWAGLLTMGVGEAANFAAYAFAPASLVTPLGALSVIISAVMASRFLNEKLNLLGKIGCFLCILGSTIIVIHSPKEKEIEDLQLLFDMLLDPVFILYVICIVGSTVFVACFIAPRHGHTNVVVYIFLCSGIGSLTVMSCKALGLAIRQTLNNGGNVFLTWMPWFLILVTVTFIAIQMNYLNKALDIFNTSIVTPVYYVMFTTLVIAASAILFKEFTHMRFDDILGDVCGFLIVITAVFLLNAFRDIDISLNDVRGLMRPKMQRVSQFDEEVLVTSNTKERRLSYGSS-----DIFRKAXHKQRYQV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: .: *****:***::*.:***.***:***.*:**:* *.:**. **..**:**:******:**.**.***********:**********::**:::* ****:*** *****:*.*****::***:***:*** *: : . * ** *:::. :* :::. .:.****:**::*** :** **:::* . *.**::*:: : * *: :.*:*:: :. :: *:****:************:***:*** *::.*******: .* .**::* :.**: :*..:***:**:*:.:** .: :* . : :. ..: . *.:* *. * . :: *: : : ", "identical_positions": 173, "similar_positions": 119, "identity": "43.47%" }, { "cls_id": "homologset.agr.HGNC:17045", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q969G9-1", "uniprot_id": "NKD1_HUMAN", "id": "Q969G9-1", "name": "Protein naked cuticle homolog 1", "aln": "-------------MGKLHSKPAAVCKRRE--------------SPEGDSFAVS----AAWARKGIEEWIGRQR--CPGGVSGPRQLRLAGTIGRSTRELVGDVLRDTLSEEEEDDFRLEVALP---------------PEKTDGLGSGDEKKMERVSEPCPG------SKKQLKFEELQCDVSMEEDSRQE---WTFTLYDFD-NNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKMLRVKLTVAPDGSQSKRSVLVN-------------------------------------------------------------------------------------------------------------------------------------------------QADLQSARPRAETKPTEDLRSW-------------------------------------------------------------------------------------------------EKKQRAPLRFQGDSRLEQSGCYHHCVDEN---------IERRNHYLDLAG--------------------IENYTSQFGPGSPS-VAQKSELPPRTSNPTRSRSHEP------------EAIHIPHRKPQGVDPASFHFLDTPIAKVSELQQRLRGTQDGSKHFVRSPKAQGKS---------VGVGHVARGARNKPPLGPAIPAVSPSAHLAASPALLPSLAPLGHKKHKHRAKESQQGCRGLQ----------------------------------------------------------------------------------------------------------APLASGG-PVLGREHLRELPALVVYESQAGQPVQRHEHHHHHEHHHHYHHFYQT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99MH6-1", "uniprot_id": "NKD1_MOUSE", "id": "Q99MH6-1", "name": "Protein naked cuticle homolog 1", "aln": "-------------MGKLHSKPAAVCKRRE--------------SPEGDSFAVS----AAWARKGIEEWIGRQR--CPGSVSGPRQLRLAGTVGRGTRELVGDTSREALGEEDEDDFPLEVALP---------------PEKIDSLGSGDEKRMERLSEPGQA------SKKQLKFEELQCDVSVEEDSRQE---WTFTLYDFD-NNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKRSVLFN-------------------------------------------------------------------------------------------------------------------------------------------------HTDLQSTRPRADTKPAEELRGW-------------------------------------------------------------------------------------------------EKKQRAPLRFQGDSHLEQPDCYHHCVDEN---------IERRNHYLDLAG--------------------IENYTSQFGPGSPS-VAQKSELPPRISNPTRSRSHEP------------EAAHIPHRRPQGVDPGSFHLLDTPFAKASELQQRLRGTQDGSKHFVRSPKAQGKN---------MGMGHGARGARSKPPLVPTTHTVSPSAHLATSPALLPTLAPLGHKKHKHRAKESQASCRGLQ----------------------------------------------------------------------------------------------------------GPLAAGGSTVMGREQVRELPAVVVYESQAGQAVQRHEHHHHHEHHHHYHHFYQP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q2TJA6-1", "uniprot_id": "NKD1_DANRE", "id": "Q2TJA6-1", "name": "Protein naked cuticle homolog 1", "aln": "-------------MGKLHSKHAAICKARE--------------SPEGDSFVVN----ACLARKGLDDWMVKQKYYCSSSRVDQRDCQQKNNCELSPRDPLDEGYAEGISDEH---YRLEVALP---------------PEKTDSC-SVEERMQGTEGSATVG------PHKQLQFEELECAVSVEEDNRQE---WTFTLYDFD-NNGKVTREDITSLLHTIYEVVDASVNHSPSSSKTLRVKLSVAPDSSQRWKNCTQT-------------------------------------------------------------------------------------------------------------------------------------------------NTDTPNPKHKGE-KCIEDSKTS-------------------------------------------------------------------------------------------------EKKSRAFLRRYHAEHHSQQGCQRHCVDEN---------LERRNHYLDLAG--------------------IENYTSRFGTAAPATEPAKPTHATRSSNQSRSRSQEP------------ENGQ--------VHPAHHRRSQTMSTDPPAILTRHT-------HALRSPKTHRTP---------PTQASAGRVMRRGAPPPPSVPNQTP-PHQSSGP----------YRRHKQRPKEALH-YRALG----------------------------------------------------------------------------------------------------------PSVTSGP--VLEKEHVRDLPSLVLYEGGLAQVVQRHEHHHHHEHHHHYHHFYQS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VVV9-1", "uniprot_id": "NKD_DROME", "id": "Q9VVV9-1", "name": "Protein naked cuticle", "aln": "MAGNIVKWWKHKILGGYKQFSVQECTTDSEELMYHQVRASSSCSAPPDLLLVSERDNNIQLRSPVVNIITTPPGNASGAGSKQQSHHQTNHHSSGRSHPGHTAHPQDVSSGGSHSKHLRISSTSNGKHGKYSNMQQQLPQDEDVVDAAATMQQQQHTGHAHSRHLHHHKEERIRLEEFTCDVSVEGGKSSQPLQFSFTFYDLDGHHGKITKDDIVGIVYTIYESIGKSVVVPHCGSKTINVRLTVSPEGKSKSQPVVPVPVAAGFSSSHASKLKKLPTGLAAMSKPLAGGGVGSGGASALTTSAGNRRQHRYRPRKLIKSDDEDDDSNSEKEKDAAHAPAADQPSGSGTKATGKSHHHQSQSARYHQKNNSRAEQCCTEQNTPDNGHNTYENMLNLKCCKPEVDQVDCPSHRQHHQSHPNHQMRQQDIYMKQATQRVKMLRRARKQKYQDHCLETRQRSLSVGNDSACPNRHLQLQQPPVGHPQPQSLNHKSASGSPPLGVGGGGDMMLDGVQLRQPRPHSLTPHQHQQQNQQQQQQQRKSAECWKSALNRNDLISIIRESMEKNRLCFQLNGKPQANVSPIRQPAAQQQPQQQQRQRCNTGSKIPTLITNHSPVAQQSPLSCSPPTAEPTTPSIPAAPPAIEVNGQQHHPTHPTHPSHHNHHEHPQPHIPIYHQQLAINPAVLAAQQTHNTAHNKLNLCGYDSFLHATICGGGAAAHSPPATPSNVATVQPIPKKSQKNLLQGYQRLEQSQQQQQQQRSSKDYKNYGNLIYAKLSEQLQQKDREQRRQRHKQQQHQMLQDQPKDASRSEQRPPTSNSSSAGSKIYGDAVECAHLLASEEEDLPPSPQLTSTPSKVVSTDTLIDLNDDVGEAVAEAVTEGGKQSLEAEESGQQVEVELDTSASSSMIHRYVHEHIHHHYHHFKEQQDV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :. . *. . *. * : *. *. : : : .... :. : . . . : :.. *.:: . *:. * : . .:::::**: * **:* .. .: ::**:**:* ::**:*::**..:::**** :. ** . .** :.*:*:*:*:... : :.* . : : : : .: : :: : : .: .. * : .::.* :*:.. ::* * :. .. *. *: . :. . : . . : ** * ..*. .. : .. . : .:: . . .* *: : ::::: :.: : .:: * : *. : : : . .. ::*: *.* *.*:**::. : ", "identical_positions": 60, "similar_positions": 166, "identity": "6.47%" }, { "cls_id": "homologset.agr.HGNC:17046", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A182-1", "uniprot_id": "D4A182_RAT", "id": "D4A182-1", "name": "Protein naked cuticle homolog", "aln": "-------------MGKFQSKHGEEPAGGRERGSGWAPPLTVPSLFPVSSDRAAAAAACKRRESPEGDSFVVS-AYASGRKGAEETDRRAGSGVEHRARDKQELPNGDPKEGPFWEDKGSLEVVLPPEKSEGHEG--QLFSVDDGEKAANREGPL------------RLSKKHLNIDALQCDVSVEEDNRQE---WTFTLYDFD-NSGKVTREDMSSLMHTIYEVVDASVNHSSGSSK-TLRVKLTVSPEPSSK-----------------------------------------------------------------------KEWLPPGQEREPTRGRTESELPDDPRVADRRLSAYSRKPNTDPQPCPVRVPYCVDEN---TERRNHYLDLAGIENYTSKFGPGSPPEQARQEHHGRATHIPS----------------RSRSQESDAHAIHHRRSQVLAEHIVPANEPAPRA-----LAAQPRLKGQEKQFLRSPKGPGKPLG-APSGSKPGKSLSHCLQAVPLSQGAQDGHHLPQPPPQPPPQPYGH-------KRYRQKSREGHSPLKG-HGQPTMVEHEVVRDLPPMLGPE------------GYVVPMIQR----------------------------HEHHHHHEHHHHHHHHHFHPNAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VE28-1", "uniprot_id": "NKD2_MOUSE", "id": "Q8VE28-1", "name": "Protein naked cuticle homolog 2", "aln": "-------------MGKFQSKH--------------------------------AAAACKRRESPEGDSFVVP-AYGSGRRGAEETDRRAGSGVEHRSRDKQELLNGDPKEGPFWDDKGSLEVVLPPEKSEGHEGQGQLFSTDDGEKAASREGPL------------RLSKKHLNIDALQCDVSVEEDNRQE---WTFTLYDFD-NSGKVTREDMSSLMHTIYEVVDASVNHSSGSSK-TLRVKLTVSPEPSSK-----------------------------------------------------------------------KECPLTGQDREPTRGRTEIELTDEPRVADRRLSAYSRKPNADPQPCSVRVPYCVDEN---TERRNHYLDLAGIENYTSKFGPGSPPEQARQEHHGRATHIPS----------------RSRSQESDAHAIHHRRSQVLAEHVIPANEPATRA-----LAAQPRIKGQEKQFLRSPKGPGKPLG-TPGSGKPGKALSYCLQAVPLPQSAQDGHHLPQPPPQPPPQPYGH-------KRYRQKAREGHSPLKG-HGQPTMVEHEVVRDLPPMLGPE------------GYVMPVVQR----------------------------HEHHHHHEHHHHHHHHHFHPS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969F2-1", "uniprot_id": "NKD2_HUMAN", "id": "Q969F2-1", "name": "Protein naked cuticle homolog 2", "aln": "-------------MGKLQSKH--------------------------------AAAARKRRESPEGDSFVAS-AYASGRKGAEEAER--------RARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPR------------GPGGQRLNIDALQCDVSVEEDDRQE---WTFTLYDFD-NCGKVTREDMSSLMHTIYEVVDASVNHSSGSSK-TLRVKLTVSPEPSSKR----------------------------------------------------------------------KEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDEN---TERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQA----------------RSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARA-----LDTQPRPKGPEKQFLKSPKGSGKPPG-VPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPP----PYGH-------KRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGE------------GYAVPVIQR----------------------------HEHHHHHEHHHHHHHHHFHPS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A4ZNR4-1", "uniprot_id": "NKD2_DANRE", "id": "A4ZNR4-1", "name": "Protein naked cuticle homolog 2", "aln": "-------------MGKLHSKH-----------------------------------ACKRRENPEGDSFVVN-GFIAKR-AAEEGER--------YGNNLKDYKNEELKDSQPTLLHCPLQVVLPPEKAEGCESFLQYLSPDDEERDAQK------------------VTKRISLQDLECNVSLAEDNRQE---WVFTLYDFD-NSGKVTKEDMSSLMHTIYDVVDASVKHSCNSKRRSLRVKLSVTPEPAARR----------------------------------------------------------------------RDATHTERETS-HLSQVEPVRSEEHRSADRRQSTHIRG-QTEAHEGN---HYCVDEN---TERRNHYLDLAGIENYTSRFDSSSP--DADQDPPSRSSHSQS----------------RPHSQEPETH-VYQRRSQLMEPCVAPDPR----------LRTGPQLIRS-----RSPKGSSRYPGVIPNVTKTSKCHGHHQPIS----AGQDVYHLTQ-----------------------QSHTHAHTPSGLQHSHSRRIRSRAREQQALTPVKN------------TNATALVQR----------------------------HEHHHHHEHHHHHHYHHYHQT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A4ZNR5-1", "uniprot_id": "NKD2L_DANRE", "id": "A4ZNR5-1", "name": "Protein naked cuticle homolog 2-like", "aln": "-------------MGKLHSKH-----------------------------------ACKRRENPEGDSFVVN-GFIAKR-AAEEDER--------YGNNLKDYKNEELKDGRLTLLHCPLQVVLPPEKAEGCESFLQYLSPDDGERDAQK------------------VKKRISLQDLECNVSLAEDNRQE---WVFTLYDFD-NSGKVTKEDMSSLMHTIYDVVDASVKHSCNTKRRSLRVKLSVTPEPAARR----------------------------------------------------------------------RDATHTERETS-HLSQVEPVRSEEHRSADRRQSTHIRG-QTEAHEGN---HYCVDEN---TERRNHYLDLAGIENYTSRFDSSSP--DADQDPPSRSSHSQS----------------RPHSQEPETH-VYQRRSQLIEPCVAPDPR----------LRTGPQLIRS-----RSPKGSSRFPGVIPNVTKTSKCHGHHQPIP----TGQDVYHLTQ-----------------------QNHTHAHTPSGLQHSHSRRIRSRAREQQALTPVKN------------TNATALVQR----------------------------HEHHHHHEHHHHHHYHHYHQT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VVV9-1", "uniprot_id": "NKD_DROME", "id": "Q9VVV9-1", "name": "Protein naked cuticle", "aln": "MAGNIVKWWKHKILGGYKQFSVQECTTDSEELMYHQVRASSSCSAPPDLLLVSERDNNIQLRSPVVNIITTPPGNASGAGSKQQSHHQTNHHSSGRSHPGHTAHPQDVSSGGSHSKHLRISSTSNGKHGKYSNMQQQLPQDEDVVDAAATMQQQQHTGHAHSRHLHHHKEERIRLEEFTCDVSVEGGKSSQPLQFSFTFYDLDGHHGKITKDDIVGIVYTIYESIGKSVVVPHCGSK-TINVRLTVSPEGKSKSQPVVPVPVAAGFSSSHASKLKKLPTGLAAMSKPLAGGGVGSGGASALTTSAGNRRQHRYRPRKLIKSDDEDDDSNSEKEKDAAHAPAADQPSGSGTKATGKSHHHQSQSARYHQKNNSRAEQCCTEQNTPDNGHNTYENMLNLKCCKPEVDQVDCPSHRQHHQSHPNHQMRQQDIYMKQATQRVKMLRRARKQKYQDHCLETRQRSLSVGNDSACPNRHLQLQQPPVGHPQPQSLNHKSASGSPPLGVGGGGDMMLDGVQLRQPRPHSLTPHQHQQQNQQQQQQQRKSAECWKSALNRNDLISIIRESMEKNRLCFQLNGKPQANVSPIRQPAAQQQPQQQQRQRCNTGSKIPTLITNHSPVAQQSPLSCSPPTAEPTTPSIPAAPPAIEVNGQQHHPTHPTHPSHHNHHEHPQPHIPIYHQQLAINPAVLAAQQTHNTAHNKLNLCGYDSFLHATICGGGAAAHSPPATPSNVATVQPIPKKSQKNLLQGYQRLEQSQQQQQQQRSSKDYKNYGNLIYAKLSEQLQQKDREQRRQRHKQQQHQMLQDQPKDASRSEQRPPTSNSSSAGSKIYGDAVECAHLLASEEEDLPPSPQLTSTPSKVVSTDTLIDLNDDVGEAVAEAVTEGGKQSLEAEESGQQVEVELDTSASSSMIHRYVHEHIHHHYHHFKEQQDV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :. : ..* : :.. . : . :: .: .. : : ... : :. . ::.: : * . :* * ::: :: : *:**: .. .: : **:**:* : **:*::*: .:::***: :. ** . .: ::.*:*:*:** :: : . :: . . . * : : : * *: : :* * :: .:: ..... . . :. : *.:.*: : * : *: .: . . . *: .* * . . : : : *: : : :. . :.: :. . .: . : .: *: ::** * * ** ** * ", "identical_positions": 50, "similar_positions": 141, "identity": "5.38%" }, { "cls_id": "homologset.agr.HGNC:1705", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P42082-1", "uniprot_id": "CD86_MOUSE", "id": "P42082-1", "name": "T-lymphocyte activation antigen CD86", "aln": "-----MDPRCTMGLAILIFVTVLLISDAVSVETQAYFNGTAYLPCPFTKAQNISLSELVVFWQDQQKLVLYEHYLGTEKLDSVNAKYLGRTSFDRNNWTLRLHNVQIKDMGSYDCFIQKKPPTGSIILQQTLTELSVIANFSEPEIKLAQNVTGNSGINLTCTSKQGHPKPKKMYFLIT--NSTNEYGDNMQISQDNVTELFSISNSLSLSFPDGVWHMTVVCVLETESMKISSKPLNFTQEFP---SPQTYWKEITAS----VTVALLLVMLLIIVCHKKPNQPSRPSNTASKLERDSNADRETINLKELEPQIASAKPNAE-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O35531-1", "uniprot_id": "O35531_RAT", "id": "O35531-1", "name": "T-lymphocyte activation antigen CD86", "aln": "MYVVKTCVTCTMYLGILFSVLAYLLSDAVPVKRQAYFNSTAYLPCPFTKAQNISPSELVVFWQDRKKSVLYEHYLGAEKLDNVNAKYLGRTSFDRDNQALRLHNVQIKDTGLYDCFIQQKTPTGSIILQQWETELSVIANFSEPEIEEAQNETRNTGINLTCSSKQGYPKPTKMYFLIT--NSTNEYGDNMQISQDNVTKLFSVSISLSLPFPDGVYNMTIVCILETESMNISSKPHNMVFSQPQ--FDRKTWIQIAGPSSLLCCLFLLVVYKAVKKCLKMQNQPGRPSRKTCESKQDSGVD-ESINLEEVEPQLHQQ----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P42081-1", "uniprot_id": "CD86_HUMAN", "id": "P42081-1", "name": "T-lymphocyte activation antigen CD86", "aln": "-----MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** *. :: * . *:*.*..:: ***** ** *** *:::** * *********::: ** * *** **:*.*::**:****** :. :*****:**** * *:*:*::* *** * ::* :****:****:*** .* * * *****:* :*:*:*.** .*: *** **.. ** ******:*:.:* ***:.*** . :**:.*:***:. .: *.* .: . * : * . . : : :: : *. :.. . : :. . *.*:: * . : ", "identical_positions": 129, "similar_positions": 85, "identity": "38.62%" }, { "cls_id": "homologset.agr.HGNC:17050", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P12749-1", "uniprot_id": "RL26_RAT", "id": "P12749-1", "name": "Large ribosomal subunit protein uL24", "aln": "-MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIRPSKVVITRLKLDKDRKKILERKAKSR--QVGKEKGKYKEETIEKMQE--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "M0RE23-1", "uniprot_id": "M0RE23_RAT", "id": "M0RE23-1", "name": "Large ribosomal subunit protein uL24", "aln": "-MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIQKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSR--QVGKEKGKYKEETIEKMQE--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P61255-1", "uniprot_id": "RL26_MOUSE", "id": "P61255-1", "name": "Large ribosomal subunit protein uL24", "aln": "-MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSR--QVGKEKGKYKEETIEKMQE--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UNX3-1", "uniprot_id": "RL26L_HUMAN", "id": "Q9UNX3-1", "name": "Ribosomal protein uL24-like", "aln": "-MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSR--QVGKEKGKYKEELIEKMQE--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D4AE42-1", "uniprot_id": "D4AE42_RAT", "id": "D4AE42-1", "name": "Large ribosomal subunit protein uL24", "aln": "-MKFNPFVTSDRSKNRKCHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDKVQVVRGHYKGQQIGKVVQVYRKKYIIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDCKKILERKAKSR--QVGKEKGKYKEETIEKMQE--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VVU2-1", "uniprot_id": "Q9VVU2_DROME", "id": "Q9VVU2-1", "name": "", "aln": "-MKQNPFVSSSRRKNRKRHFQAPSHIRRRLMSAPLSKELRQKYNVRSMPIRRDDEVQVIRGHFKGNQVGKVVQAYRKKFVVYVEKIQRENANGTNVYVGIHPSKVLIVKLKLDKDRKAILERRGKGRLAALGKDKGKYTEETAAQPMETA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53221-1", "uniprot_id": "RL26B_YEAST", "id": "P53221-1", "name": "Large ribosomal subunit protein uL24B", "aln": "MAKQSLDVSSDRRKARKAYFTAPSSERRVLLSAPLSKELRAQYGIKALPIRRDDEVLVVRGSKKG-QEGKISSVYRLKFAVQVDKVTKEKVNGASVPINLHPSKLVITKLHLDKDRKALIQRK-----------GGKLE-----------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P05743-1", "uniprot_id": "RL26A_YEAST", "id": "P05743-1", "name": "Large ribosomal subunit protein uL24A", "aln": "MAKQSLDVSSDRRKARKAYFTAPSSQRRVLLSAPLSKELRAQYGIKALPIRRDDEVLVVRGSKKG-QEGKISSVYRLKFAVQVDKVTKEKVNGASVPINLHPSKLVITKLHLDKDRKALIQRK-----------GGKLE-----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . *:*.* * ** :* *** ** ::*:******* :*.::::**::**:* *:** ** * **: ..** *: : :::: :*:.**:.* :.::***::*.:*:**** * :::*: ** ", "identical_positions": 55, "similar_positions": 44, "identity": "36.67%" }, { "cls_id": "homologset.agr.HGNC:17052", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z2Q1-1", "uniprot_id": "SC31A_RAT", "id": "Q9Z2Q1-1", "name": "Protein transport protein Sec31A", "aln": "-MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSSSHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFA------TPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSN----RMHCSGLAWHPDVATQMVLASEDDRLPVVQMWDLRFASSPLRVLEN-HARGILAIAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRIRVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTSQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVTGQPQQGAEQPRRQP-VFISQVVTEKDFLSRSEQLQHVVQSQGFISYCQKKIDASQTDFEKNVWSFLKVNFEEDSRGKYLELLGYRREDLGEKIALALNRVDGSDVALKDSDRVAQSDGEESPAEEGQLLG-ERIKEEKQECD---------------FLPSAGGGTFNISVSGDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQK-KYFAKS--QSKITRLITAVVMKNWKEIVESCDLKNWR--EALAAVLTYAKPDEFSALCDLLGARLESEGDS--LLRTQACLCYICAGNVERLVACWTKAQ--------------DGSNPLSLQDLIEKVVILRKAVQLTQALDTNTVGALLAEKMSQYANLLAAQGSIAAALAFLPDN------TNQPDIVQLRDRLCRAQGRSVPGQESSRSSYEGQPLPKGGPGPLAG----HPQVSRVQSQ--------QYYPQVRIAPTVTTWSDRTPTALPSHPPAACPSDTQGGNPPPPGFIMHGNVVPNSPAPLP----TSPGHMHSQPPPYPQPQPYQPAQQYSLGTGGSAVYRPQQPVAPPASKRYPNAPYV--------------------SPVASYSGQPHMYTAQ-PASSPTSSSAPLPPPP-SSGASFQHGGPGAPPSSSAYALPPGT--TGTPPAASELPASQRT-------------GPQNGWNDPPALN--RVPKKKKLPEN---FMPPVPITSPI----------MNPGGDPQPQGLQQQPSASGPRSSHASFPQPHLAGGQPFHGIQQPLAQTGMPPSFSKPNTEG---APGAPIGNTIQHVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLECLYDKLRDQ-TLSPTIISGLHSIARSIETRNYSEGLTVHTHIVSTSNFSETSAFMPVLKVVLSQASKLGV---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UPL0-1", "uniprot_id": "SC31A_MOUSE", "id": "Q3UPL0-1", "name": "Protein transport protein Sec31A", "aln": "-MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSSSHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFA------TPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSN----RMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLEN-HARGILAVAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQSAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFESVAVPLQQGAEQQRRQP-VFISQVVTEKDFLNRSAQLQHAVQSQGFIGYCQKKIEASQTEFEKNVWSFLKVNFEEDSRGKYLELLGYRKEDLGQKIALALNKVDGPDVALKDSDQVAQSDGEESPAAEEQLLG-ERIKEEKQECD---------------FLPSAGG-TFNISVSGDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQK-KYFAKS--QSKITRLITAVVMKNWREIVESCDLKNWR--EALAAVLTYAKPDEFSALCDLLGTRLEREGDS--LLRTQACLCYICAGNVERLVACWTKAQ--------------DGSSPLSLQDLIEKVVILRKAVQLTQALDTNTVGALLAEKMSQYASLLAAQGSIAAALAFLPDN------TNQPNIVQLRDRLCKAQGKPVSGQESSQSPYERQPLSKGRPGPVAG----HSQMPRVQTQ--------QYYP-------------------------------HGENPPPPGFIMQGNVIPNPAAPLP----TAPGHMPSQLPPYPQPQPYQPAQQYSFGTGGAAAYRPQQPVAPPASNAYPNTPYI--------------------SPVASYSGQPQMYTAQ-QASSPTSSSAASFPPP-SSGASFQHGGPGAPPSSSAYALPPGT--TGTPPAASELPASQRTENQSFQDQASILEGPQNGWNDPPALN--RVPKKKKMPEN---FMPPVPITSPI----------MNPSGDPQSQGLQQQPSTPGPLSSHASFPQQHLAGGQPFHGVQQPLAQTGMPPSFSKPNTEG---APGAPIGNTIQHVQALPTEKITKKPIPEEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQ-TLSPTIINGLHSIARSIETRNYSEGLSVHTHIVSTSNFSETSAFMPVLKVVLSQASKLGV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O94979-1", "uniprot_id": "SC31A_HUMAN", "id": "O94979-1", "name": "Protein transport protein Sec31A", "aln": "-MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFA------TPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSN----RMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLEN-HARGILAIAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDGANVALKDSDQVAQSDGEESPAAEEQLLG-EHIKEEKEESE---------------FLPSSGG-TFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQK-KYFAKS--QSKITRLITAVVMKNWKEIVESCDLKNWR--EALAAVLTYAKPDEFSALCDLLGTRLENEGDS--LLQTQACLCYICAGNVEKLVACWTKAQ--------------DGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDN------TNQPNIMQLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAG----HHQMPRVQTQ--------QYYP-------------------------------HGENPPPPGFIMHGNVNPNAAGQLP----TSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYI--------------------SSASSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGT--TGTLPAASELPASQRT-------------GPQNGWNDPPALN--RVPKKKKMPEN---FMPPVPITSPI----------MNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEG---APGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQ-TLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKLGV---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7SYD5-1", "uniprot_id": "SC31A_DANRE", "id": "Q7SYD5-1", "name": "Protein transport protein Sec31A", "aln": "-MKLKEINRTAIQAWSPAQQHPIYLAAGTSAQQLDATFSTNASLEIFELDLADSALAMKSCGSFSSPHRYHKLVWGPHGIENQGLPSGVLIAGGENGNIILYDASKIIAGDSEVIISQSEKHTGAVRALDVNSFQSNLVASGGNESEIYIWDLNNFS------SPMTPGPKTQPQEDISCVAWNKQVQHILASASPSGKASVWDLRKNDLIIKVSDHSN----RMHCSGLAWNPEVATQLVLASEDDRMPVIQMWDLRFATSPLKVLEN-HTRGILAIAWSVADPELLLSCGKDNRILCWNPNT----AEVLYELPTSTQWCFDIQWCPRNPAVLSAAAFDGHISIYSIMGGSNDNANNLQADQLSSSFGNVDPFGTGKTLPPLQLPQQTSPQSTITPLKKPPKWIRRPVGASFAFGGKLVTLDNIKPTAQQ--PQQTAAHVVHISQVVTETDFIHRSNQLQTTLNAGNFLEYCQNKIETVQNEFERTVWSFLKVNFEEDARLKYLELLGYEKEELALKIASALEGNCKPKEADMDKEEVLAEEEAESDLDDIPVNEEEPVVEETSNTE---------------VPPAPASDAINLKVSQDIDGLITQALLTGDYEAAVNLCLHDNRMADGIILAIAGGPELLAKTQR-KYFSKT--ESKISKLISAVVMKDWLDILETCDLQNWK--EALAAVMTYAKPEEFSALCGLLGSRLESSEDV--ELQAQACLCYICAGTVEQLVSFWTKTQ--------------DSCSPLSLQELVEKVVVLQRAVEKAQGAVPADMGALLAEKMNQYASLLASQGSLQTAISYLPTN------TEQVSVQQLRERLSRALGQHQHLQQPAAAVTGIQKMHQRRPAAVPMQTYTQPQPPQVPAQPAAPAVPPQYYQQGRSATTVTSWSNQTPTALPSVPRQLVPSSDPQGDSTPPAFGLQS----PAMASVP----ASTPFMYSQ-----QYQNYPPVQQFTPSAGTPGIYQP-LPYASSAGAPLPPPPSS--------------------SSSAAVYPPQFMLSASSQASAPPQSFCP--PPAVSSGGCFQHGGPGSPTS---YLPPPGARAPGTQHEPALIPASQRTDG-FYQETAWGLEGPQNGWNDPPALS--RAAKKKKVPQH---FTPPAPITAPI----------MAPLGDPQAPAGMQTLQPQQQVPDQSAGPATFT----PIQ--QQPLGPR--NPSMPQGNMEG---APGAPIGDVIKPLQAIPTEKITKKPIPEEHMVLKTTFEGLIQKCLTAASDPQTKRKLDDAHKRLELLYDKLREQ-TLSPAIIGGLHNMAQSIECRSYADGLNIHTHIVSNSNFSETSAFMPVLKVVLTQANKLGV---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4LEZ1-1", "uniprot_id": "A0A0B4LEZ1_DROME", "id": "A0A0B4LEZ1-1", "name": "Protein transport protein Sec31A", "aln": "-MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSSQYKFQKLIWSPVGP----HPSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSGLDFNPFQNNLLASCASESEILIWDLNNPE------TSMSPGTKTQPLEDVKNVAWNRQVQHILASVFST-RCVIWDLRKSQQIIKLSDSQS----RVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQI-HERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPALIASASLEGAVSIYSLHGGTHHLVQT--ANKIADSFPGMDQFAQEP-------IPQQATQVVYHDLAHAPKWMKRPCGVAFGFGGKLVSFN-------------GTSKTVKVQQLTTESALVDRANALERSLVDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGNSHSDVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNHNDFATPPRPQFKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQT-RYLLQQ--KNELSHVISALVSRDWLDFVNRCTVDSWK--EALVAALKHSE-RKVVDICERLGDRLLSECASSAEFTRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPG------YKPNTTELQDLAEMVMLMCKSLE--QQGISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVAAAPHGYQPTRGRGSFSQPQPSAPMPYGQPPN--------QYAQPSWP---------------AQVPPLQTSYPGAQQPQAPPQIFNPQPVKPEPLAQPP----RPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSSYGMPYNPVPAP--------------------VPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNPIAAAQPYNPSPLMPAQQNQFVPGVNPIETMPPPAVPPVIQNVQRNP-----------TPPPGWNDPPALKSSRAPKPKPVVEPSAAIFHPLFPVDPN----------QNQNGYVDPSQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDG-KLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASELQLVLR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38968-1", "uniprot_id": "SEC31_YEAST", "id": "P38968-1", "name": "Protein transport protein SEC31", "aln": "MVKLAEFSRTATFAWS--HDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADS---EKPIASLQVDSKFNDLDWS--------HNNKIIAGALDNGSLELYSTN--EANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPES----AEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFWNNVSRE---------ESKEKPTVFHLQAPTWYGEPSPAAHWAFGGKLVQIT---------------PDGKGVSITNPKISGLESNTTLSEALKTKDFKPLINQRLVKVIDDVNEEDWNLLEKLSMDGTEEFLKEALAFDNDESDAQDDANNEKEDDGEEFFQQIETNFQPEG-------------------------------------------------DFSLSGNIEQTISKNLVSGNIKSAVKNSLENDLLMEAMVIALDSNNERLKESVKNAYFAKYGSKSSLSRILYSISKREVDDLVENLDVSQWKFISKAIQNLYPNDIAQRNEMLIKLGDRLKENGHR-----QDSLTLYLAAGSLDKVASIWLSEFPDLEDKLKKDNKTIYEAHSECLTEFIERFTVFSNFIN----GSSTINNEQLIAKFLEFINLTTSTGNFELATEFLNSLP-----SDNEEVKTEKARVLIASGKSLPAQNPATATTSKAKYTNAKTNKNVPVLPTPGMPSTTSIPSMQAPFYGMTPGASANALPPKPYVPATTTSAPVHTEGKYAPPSQPSMASPFVNKTNSSTRLNSFAPPPNPYATATVPATNVSTTSIPQNTFAPIQPGMPIMGDYNAQSSSIPSQPPINAVSGQTPHLNRKANDGWNDLPLKVKEKPSRAKAVSVAPPNILSTPTPLNGIPANAASTMPPPPLSRAPSSVSMVSPPPLHKNSRVPSLVATSESPRASISNPYAPPQSSQQFPIGTISTANQTSNTAQVASSNPYAPPPQQRVATPLSGGVPPAPLPKASNPYAPTATTQPNGSSYPPTGPYTNNHTMTSPPPVFNKPPTGPPPISMKKRSNKLASIEQNPSQGATYPPTLSSSASPLQPSQPPTLASQVNTSAENVSHEIPADQQPIVDFLKEELARVTPLTP-KEYSKQLKDCDKRLKILFYHLEKQDLLTQPTIDCLHDLVALMKEKKYKEAMVIHANIATNHAQEGGNWLTGVKRLIGIAEATLN----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 128, "similar_positions": 377, "identity": "9.25%" }, { "cls_id": "homologset.agr.HGNC:17053", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AI30-1", "uniprot_id": "A0A8I6AI30_RAT", "id": "A0A8I6AI30-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNKTGGKRSATINSDIANHSMVSEVPPERPNIRATRTSRKAIAFGKRAHS----------------------MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKQESVLGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESSEEQEAWIQAMGEAARVQIPPAQKSVPQPVRHGLEKPDSENIPPSKHHQQSPHNNLTK--PEPKTRGEGDGRGCEKVEQRPERPEVKKEPLVKANGLPSGPETASEPG--------SPYPDGPRVLGGGEQPAQPNGWQYSSPSRPGST--------------------AFPPHDGDTGGHRRSFPPRTDPDKIAQRK---------------SSMNQLQQWVNLRRGVPPPEDLRSPSRFYPMPRRVPEYYSPYSSQYPDDYQYYPPGVRPDSICSMPAYDRISPPWALEDKRHS------------------------------------------------------------------------------------------------------------------------------------------------------FRNGGGPTYQLHEWKESTSYGR-------------------QDGTVWIPSPSRQPVYYDELDAASGSLRRLSLQ---------------------------------------------------------------------------------------------------------------------PRSHSVPRSPSQ---------------------GSYSRARIYSPVR--SPSARFDRLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRAHLFMQ-----------------------------VPAYP----------------------------------------EVFRDGLHTFKLNEQDTDKLLGKLCEQNKVVREQERLVQQLRAEK------------------------------------------ESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALTNSTVVYENLES--------------------------------EVSALHDDLWEQLNLDIQNEVLSRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSAS------------------------LTSPLSPFSMVSGSQGSPTKPGSSEEPGPPRPPLPKAYVPLDSPPTVPPLPNESRFWPYPNSPSWHRSGEAAKGQPKTDYEPSKKDPGQTSPLDTHRDISLVPTRQEVEAEKQAALNKVGIVPPR-TKSPAEEEITPSAVVRRTTDGLTNGFSSRQERPKSAVFSGEGKVKMSVEEQMDRMRRHQSGSMKEKRRSLQLPASPAPEPSTRPTYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETP------------REEIARLRKMELEPQHYDVDINKELSTPDKVLIPER------------------------YIDLEPVAPLSPE-ELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVP------QDSESQLQEQEKRIEISCALATEASRRGR----------------------MLSVQCATPSPPTSPASPTPPVNPLSSDRPRGADSSHTMRV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TQG1-1", "uniprot_id": "PKHA6_MOUSE", "id": "Q7TQG1-1", "name": "Pleckstrin homology domain-containing family A member 6", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNKTGGKRSATINSDIANHNMVSEVPPERPNIRATRTSRKAIAFGKRAHS----------------------MKRNPNAPVTKAGWLYKQASSGVKQWNKRWFVLVDRCLFYYKDEKQESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQPVRHSLEKPDSENIPPSKHHQQPPHNNLTKLEPEAKTRGEGDGRGCEKAERRPERPEVKKETLVKANGLPSGPETASEPG--------SPYPDGPRVPGGGEHPAQPNGWQYSSPSRPGST--------------------AFPPHDGDSGGQRRSFPPRTDPDKIAQRK---------------SSMNQLQQWVNLRRGVPPPEDLRSPSRFYPMPRRVPDYYNPYSSQYPDDYQYYPPGVRPDSICSMPAYDRISPPWALEDKRHS------------------------------------------------------------------------------------------------------------------------------------------------------FRNGGGPTYQLHEWKESTSYGR-------------------QDGTVWIPSPSRQPVFYDELDAASGSLRRLSLQ---------------------------------------------------------------------------------------------------------------------PRSHSVPRSPSQ---------------------GSYSRARIYSPVR--SPSARFDRLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNYPSSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRAHLFMQ-----------------------------VPAYP----------------------------------------EVFRDGLHTFKLNEQDTDKLLGKLCEQNKVVREQERLVQQLRAEK------------------------------------------ESLESALMGTHQELEMFGSQPAYPEKLLHKKESLQNQLINIRVELSQATTALTNSTVVYENLES--------------------------------EVSALHDELWEQLNLDIQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSAS------------------------LTSPLSPFSMVSGSQGSPTKPGSSEEPGPPRPPLPKAYVPLESPPTVPPLPNESRFWPYPNSPSWHRSGETAKGQPKTGYETSKKDPSQTSPLGTPRDINLVPTRQEVEAEKQAALNKVGIVPPR-TKSPAEEELTPSAVVRRTTNGLTNGLSSRQERPKSAVFSGEGKVKMSVEEQMDRMRRHQSGSMKEKRRSLQLPASPAPEPSTRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGQAYETP------------REEIARLRKMELEPQHYDVDISKELSTPDKVLIPER------------------------YIDLEPDTPLSPE-ELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVP------QDSESQLQEQEKRIEISCALATEASRRGR----------------------MLSVQCATPSPPTSPASPTPPVNPLSSDRPRGADSSHTMRV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2H5-1", "uniprot_id": "PKHA6_HUMAN", "id": "Q9Y2H5-1", "name": "Pleckstrin homology domain-containing family A member 6", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHS----------------------MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPG--------SPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGST--------------------AFPSQDGETGGHRRSFPPRTNPDKIAQRK---------------SSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHA------------------------------------------------------------------------------------------------------------------------------------------------------FRNGGGPAYQLREWKEPASYGR-------------------QDATVWIPSPSRQPVYYDELDAASSSLRRLSLQ---------------------------------------------------------------------------------------------------------------------PRSHSVPRSPSQ---------------------GSYSRARIYSPVR--SPSARFERLPPRSEDIYADPAAYVMRRSISSPK-------------------------------------------------------------------------------------------------------VPPYP----------------------------------------EVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEK------------------------------------------ESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLES--------------------------------EVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSAS------------------------LTSPLSPFSLVSGSQGSPTKPGSNE--------------------------------------------------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPR-TKSPTDDEVTPSAVVRRNASGLTNGLSS-QERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETP------------REEIARLRKMELEPQHYDVDINKELSTPDKVLIPER------------------------YIDLEPDTPLSPE-ELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVP------QDSESQLQEQEKRIEISCALATEASRRGR----------------------MLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8JR01-1", "uniprot_id": "A8JR01_DROME", "id": "A8JR01-1", "name": "", "aln": "MDAKKLQQLQEAAILAQQQKKLPLAYQTNLVDYRTAAYSQALYQQSPTATSSSGGGPLSPIDMQPQSKHYNLMKHGGGTSSSSHSSPYHQSYSSSGGTAAGEQLYQSPTERTYLAAAGRLHANNAMAGHHPISALQSQYQQLQAAKMQAQMATQSEAAQQQQRTFALRQAMNPPTNHYHMSQSSSMVSTMTALNQQQQQQQQQQQQQQQQQRAPPSSLNLQNQYQPAQGPLKLQQQQQQQQQQSQQPAMPKHYQEQLYAQQQQLQQQLHQQQQQQQQLQQQQQQHRHKNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSSEESSSNSTKSPSHAPLDRKKSAGSIQALKSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMRTYWLAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQPTPSSENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYTPNHLEASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYERAYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNEQFLRSASARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYSATAGRSSSSKTTTKATTSQAIVATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPKLRLQLPKAMGNEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYVNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDEDCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASYYLGASTPLNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVKRKDSNGKVNLSYEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSDSNYSCQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPLSQESISEIESLSEQFEETLSSHELDTYLSHLHLSTGQATPTSHLLNDANAAAGADILTNLIKPPKTFRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATALRIIHSRNNSNISTQSAPYYYSELPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQAIDSKNIYCGQKDNNEKLSNKNLKLNKSVDLPAEMEGSGSSGGALNPVVHSYLTTTKNTNLARKTIGGSNPSDDGNPNEDGAGENTEEAGKTPSNNVHTNLSVLGGELLWEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKAKLSREVTYVNDSLKPRQHPHITNEHDVYVQLMDTTSSSHDHDQTDSDVYEVLREETASNLSHKSNELDRETIRQWDAMSSGLMKSNHSGVEATGASSAHLPLTSSVRSIVQQLNNSSMDDANGNPMATASISVRNVNNLPVGNLTVKPDPSDVHQESAFAPYYGGAAETKYAKNTVLTDRGLYAANGSGLATSTPQNHQQFRMRHTGSRAEIDMLERETSSQIRNRLRSAEGLTRAESIQRLDYLKQHLLDLERHYEKSKPLVNLVDNMVKLGSLYRNDANGRVQPATLDRLEFNQRMQEQQMLQEEQQQWERLSPNQAELQVRELYQLDQLLQEESGTLQSLQRDKEDLERALGGLRARIHDSNATPMALEAAKKQQHILERELSRVHQLLAENSKKLEQTVAGNARLEQELLLLRQKVQAVRGSTTNGMNGDGSHINGDQTAAVLASELERVQSLVGDMQRQRHELSSAVRQLTENSTRLYQEIGNKEMNGGGSTNGSLKKRSNSTSWTETDLDANMLRCGSRQQLNDSTLNLSTPLYVDTNSSTKLSDYNRYNGSSDAIEMSGVDSDGFLDSNPFALGLEKQEIKTVRIVKRESERRNRDRSERGLSNSIQNLDQVLEEEQYAQQQREQQLYAQNLEEPMTNGHHSRSKSLPRNYSEPPKQRHSRHLNGGKQNGHHYNGGYDYDRNSNYEHQPPPPPAPQSNGHHHNHQQREQREHLNPLANAYFAKQLQQQANPSRDSARVALRTKTDSLQSLNKSLTDISPEPVFQSVAARQIINEMSAGSASEDTEKVVEKVPPHHKHRRAVPREKRRHYTAPNNVNQKAMEKVQAENDMNRNNTNWRARDDLDMEVALRPRMNAPDVVRSALGQGEKISENTIDNLLLAPNKIVIPERYIPETLSPEEKKRRQEKVESIKKMLAEAPISSNENESLPPSKINAEKKQREHLLQLNQILAQQVMQVSKIVAGNPTSHN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. . : .. :.: .** : . .: . ::.. *. . : .: ::* ** *.:*** :***.**.*.*:* *.******.: **:***. ::*.:***: * *:**:* *.*:* **.:**.** .:***:::*:..* *::*:. *: :* *.: :* *. .. :..: . :.:. :.. . :. : * *.* * . * :*. :: .: . . : ..*. . * : : . :: **: : :*.* . * :: : : : : .::* .: .: ** :: .* .* . . . .*::. . ..:* . *. . . * ..: : . .:* * .* : :..:* . ** : .: . ...:* ** : .::: ** * * : .: : .: **. : * : .: ** *: *: . .:**.. *.*:: .. *: * * .:* : .:.*.* ** * ::*:: . * :::: :: * .*.: : *:: . :: :: *::** :. .:**: : : . . . : .:* : :***.*. . *: *. *. :*:: : :: :* ...: : . :..:: :*.... ...:*:* * . . .. ..* .*:* * *:..: * * *:. . .: .... ** . :. : :: * * :. * . : .:.. . * .**: :: : .: . *. : .:. :..:. :.* :. ..:..: :* *:: .:*::....: .:* *. .. .: .. . :. :*:*. : * .: : . : :*: * * **: :* ** . : * * :* . .**. : ::: : :: :*:. * : .:: . :.:.:::* :*.:.:*.::: ::: * *.:* . * :: :.** .* . . *. .: . . : .: * ", "identical_positions": 192, "similar_positions": 434, "identity": "6.21%" }, { "cls_id": "homologset.agr.HGNC:17054", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZLP4-1", "uniprot_id": "A0A8I5ZLP4_RAT", "id": "A0A8I5ZLP4-1", "name": "", "aln": "MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSGISELFISSTDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHFGINKPEKIVPSPDDSK--------------------------------FLLKTFTNIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGEKDGRPLWQKVDDRFFWNKYMIQDLSEIGTPDVDFWIIPIIQGFVQIEELVVNY-EPSDDDKSSPETPPQEATCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPRLTYVSFDFHEHCRGMKFENVQTLTDAIHDIILDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG----------IPVTEDLYSIFTKEKE-----------------------------------------------------------HEALQKETQRSHQELISQLLQSYMQLLLPGDEKFHGGWALIDCDPSLTDAAHRDVDVLLLLSNSAYYVAYYDDEVDKVSQYQRRSLEDLEKIEIGP--EPTLFG--KPKFSCMRLHYTCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLHVPIIERKLERKSSKPHEDIIGIR----SQNQGS-LAQGKSFLMSKFSSLNQKVKQTKSNVNIGNLR---KLGNFTKPEVKVNFLKPNLKVNLWKSDSSLETME-NPGVMGNKVQGESDGDVSSDNDSYHSDELLTNSRSEEGKQLANSLESAGPTDYLLPSCGIIASAPRLGSRSQSASSTDVSIHAPSEATVGHGHELGKGLESPLKKSP---SADNIHTLTGFAKPMDVYCQRFVQDAQNKMNALSEVRAVAQNS-EEGNHKTNPVSNEETQSESVEQMPSRPSQLNVSCSVTGPQLLSVEPAHPAVSQKTPGSGSSLLDLEAGLCVTPS-SESSS-RAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAEPEVVNEIQQNELKNMFTQCQTRIIQI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CDA1-1", "uniprot_id": "SAC2_MOUSE", "id": "Q8CDA1-1", "name": "Phosphatidylinositide 4-phosphatase SAC2", "aln": "MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHS----------DLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHFGINKPEKIIPSPDDSK--------------------------------FLLKTFTNIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQALTEIGTPDVDFWIIPIIQGFVQIEELVVNYNESSDDDKSSPETPPQDSTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHHHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPKLTYVSFDFHEHCRGMKFENVQTLTDAIHDIIIDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG----------VPVTEDLYSIFTKEKE-----------------------------------------------------------HEALHKESQRSHQELISQLLQSYMQLLLPGDEKFHGGWALVDCDPSLTDAAHRDVEVLLLLSNAAYYVAYYDDEVDKVNQYQRLGLEDLERIEIGP--EPTLFG--KPKFSCMRLHYRCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLDVPIIEKKLERKSSKPHEDIIGIR----SQNQGS-LAQGKSFLMSKFSSLNQKVKQTKSNVNIGNLR---KLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETME-NPGVMGNKVQGESDGDISSDNDSYHSDEFLTNSKSEEDKQLANSLESVGPIDYILPSCGIIVSAPRLGSRSQSASSIDVSTHAPSEAAAGPGSELGKGLESPLKKSP---SADSIHTRTGFTKPMDVYCQRFVQDAQNKMNDLSEIRSVAQKS-EEGSHKTNRVSNEETQSEPMGQTPPRPSQLNVSCSVAGPPFLSVEPVHSVLSQKTPSSGSSLLELEAGLCVTPS-SESSSSRAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAEPEAVNEIQQNELKNMFTQCQTRIIQI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2H2-1", "uniprot_id": "SAC2_HUMAN", "id": "Q9Y2H2-1", "name": "Phosphatidylinositide 4-phosphatase SAC2", "aln": "MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHS----------DLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSK--------------------------------FLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQG----------IPVTEDLYSIFTKEKE-----------------------------------------------------------HEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGP--EPTLFG--KPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIR----SQNQGS-LAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLR---KLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETME-NTGVMD-KVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSP---SAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSN-ETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8E7C5-1", "uniprot_id": "SAC2_DANRE", "id": "A8E7C5-1", "name": "Phosphatidylinositide 4-phosphatase SAC2", "aln": "MELFQAKDHYILQSGDNALWCSRKDGSMAVRPATDLLLAWNPVCLGLVEGIIGKMQLHV----------DLPLGLILIRQKALVGQLPGDHKVYKITKIVVIPLSEDEPQDLELELCKKHHFGINKPERITQSPDETK--------------------------------FLMKTLSQIKSNVGAPIKKKVKENKEKERLERRLLDELYKIFMDSDSFYYSLTYDLTNTVQRQGELGKSDQPLWKRVDDRFFWNKHMIKDLVDLQAPQVDFWVIPIIQGFVQVEELVVNYNESSDEERSSPETPLQEPTCVDDIHPRFTVALISRRSRHRAGMRYKRRGVDTDGHVANYVETEQLIHVHSHTLSFVQTRGSVPVFWSQAGYRYNPRPRIEKGERETMPYFASHFEKEVETYKKLVIINLVDQNGREKIIGDAYLKQVLLYNNPNLTYVSFDFHEHCRGMKFENVQTLTDAIYDIITDMRWAWVDQAGVICQQEGIFRVNCMDCLDRTNVVQAAIARVIMEQQLKKLGVMPPEQPLPLKCYRIYQVMWANNGDTISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFRDAYRQAVIDLMMG----------HPVTEDLYSIFSKEKE-----------------------------------------------------------HEEKEKESQRGAQEQVSLLLQTYMQLLLPDDEKFHGGWALIDCDPSLIDATHKDVDVLLLLSNSAYYVAYYDEEADKVNQYQRLSLEGLEKIEIGP--EPTLFG--KPKYCCMRLHYKNGETSGYFHTLRSVTRNPEDDGKDTLQCIAEMLRITKQAMGLDVQVVEKKLERRHSKPHEDIMGIQGKAVDQVLGSGLAQGKSFFLNKFSTLNQKVKQTKTNVNIGNFKPLGKLGTFSKPEVKVNFLKPNLHMNLWKSDSSLETHDSNTGSGALKDHGPHSEEISSDSDSYNSDEQPCSGSREN-------------VDYVLPSCGIVASAPRLGSRSQSIGSVEIAVPSVIRVTGCDEKTMDS-LSVAADQSPGAASEAEEAILIDFGTPIDVYCHQFVQDAKTKPIEVFEEVAPAPKP--QGPQVPLAPDAKLGSSHSQNQLP-RPSQLEVESNVHGANLLTVQPVGSATSCGSQKS------LEG--ITGPSSADSNGSRVVSPFAKIRSSMVQVASLTQAGLTQGINFAVAKVQKSP-EPDAVNETQENELRAMFTQCQTRIIQI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q0KI33-1", "uniprot_id": "Q0KI33_DROME", "id": "Q0KI33-1", "name": "", "aln": "MEVFQTDSHYIFVKRDKSLWWHRRTSEFSIKAGWDLSSVDDIECIGVTHGIVGVISLPN----------VYEPHLVVVKEASAVGVLYPPHLVYKIKSICILSADD---PDTDLPNCTKHTKSNQSTPTHSVSTSNNNNASVPSSGGGSSKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAANLATKQVKSSVGIREPRHIERRITEELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQ---SQPDERFFWNKHMIRDLINLND---KTWILPIIQGFMQVENCVIGN-------------------------ECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPDENDGTENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQEGYFHMFRSAN-------LRFFNNMAYVIKTQEEVAESMTSIVEMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQLVQLSSKALSN-------MAGQFSK--LGQTFKKPQAHPSSLAATMNPQVMR------------QRDSEIESGQE----------------------------------AEKAVFTLGRKHRNSNSASSTDTDEHDNSLYEPEVDSDVEIAMDKSNYNEN--AFLPSVGIVMGNQKEDSPSSSDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVEAHEAFDDREEGVKPVSSTSARDLSLPG-----------LPTHPEANKLKQLTSPLSKLAKNIGLNLDPRKIATKTGVLSPTILSAENSPPERDPSSRDHLLELWEAEKCKTKLIAL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:**:..***: . :.:** *: . : ::.. ** . : *:*:..*::* :.* *::::: : ** * * * *:..* ::. .: : :* *.** . :.. *..:.: :*. :: :*:.: *. :* .::***: :** *:* :::***:*: *:**.:**: ...: .: *:******:**: * :: . *::*:****:*:*: *:. * :**:********* ******** .*: ********:: .: * *** *.*****::*** **:*.* **:::. ** * ** :::: * : *:***:* *:** ***** .:*: ** .* **:****::****:****.:* **: * : * *: *:**:*:.:****************:**.:.::*.** ***: ** *:* : : ::****** ******** *****:*******::*:****:*****:::..* *::**.:**** * * . : .*:: *.. : .:: * . *:: :*** : *.*.*:*.*** * . :*:.:***:: .* ** **.. **: :::: * :. **:* :..:* * . *:**:* * **** :*:. :: :* ::: ::. ::* . : :: * .: .. : . : : : .* *: :.. :. * *:* : .* **: : . : . :. . ::.*..: : : : * .*:* .* : : . . :. . . . . . ::. : * . . . .: . . .* .. . *:*. .. : . . .. : .**::*: ..: . : . . *: .. :.. .. :. :*:*::* :", "identical_positions": 307, "similar_positions": 331, "identity": "24.35%" }, { "cls_id": "homologset.agr.HGNC:17055", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M051-1", "uniprot_id": "F1M051_RAT", "id": "F1M051-1", "name": "", "aln": "----------MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDDSDTDEPSPPPPSGVATSARAHASAAPLPPRAG----PGREEPPRRQQIIHSGHFMVSSPHR------EHPPKKGYDFDTVNKQTCQTYSFG---------KTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSS---LAQDDDMLYWHKHGDGWKT---------PVPMEEDSLLDTDMLMSEFSDTLFSTLS----------------SHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMD------------------------------TFEPFQELFSSSRSIFGS-----MLPPPTSVP-----APDPSSPPSQVEEAGEQTWQGNILPNPALPPVSLPN-----------------------------SLIASSAAPSLDPTEGQGCERTSQSVDPFIQP------ADFGPSEPPLSVPQPFLPVFTMTLLSP---------------GPAPAPVPTALPLVSPPAPTLNPPTPPAFLQTQTFAGVSTSSPVITHTASATLT-----HDASATTFSQSQGLVITAHHPTPSPSPCGLALSP-------------IPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEAVSLVLKSACIAPAAFTGQPQKVIMTSAPLKRE----------GILASTVSPSSVVIASAAITRASGVTEFLS-------------HSTSSQPSPASRLFSPSAVQDALVKGEQAALHGG-PQAPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQ-KHISAEQKRRFNIRMGFNTLNSLIS----NNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQFDHMKDMFDEYVKSRILQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDP-SQLPEQASEAVTRIGKRSGES---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q2VPU4-1", "uniprot_id": "MLXIP_MOUSE", "id": "Q2VPU4-1", "name": "MLX-interacting protein", "aln": "----------MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDDSDTDEPSPPPPSGVATSARAHASAAPLPPRAG----PGREEPPRRQQIIHSGHFMVSSPHR------EHPPKKGYDFDTVNKQTCQTYSFG---------KTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRRNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSS---LAQDDDMLYWHKHGDGWKT---------PVPMEEDSLLDTDMLMSEFSDTLFSTLS----------------SHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMD------------------------------TFEPFQDLFSSSRSIFGS-----MLPPPSSLP-----AADPSSPPS----------QGNILPNTALPPASLPN-----------------------------SLITSSAAPSLDPTEGQGCERTSQTVDPFIQP------ADFGPSEPPLSVPQPFLPVFTMTLLSP---------------GPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLT-----HDASATTFSQNQGLVITAHHPTPSSSPCALALSP-------------VPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAFSGQPQKVIMTSAPLKRE----------GILASTVSPSNVVIASAAITRASGVTEFLS-------------HSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQ-KHISAEQKRRFNIRMGFNTLNSLIS----NNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLDHMRDMFDEYVKSRTLQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDP-SQLPEQASEAVTRMGKRSGES---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HAP2-1", "uniprot_id": "MLXIP_HUMAN", "id": "Q9HAP2-1", "name": "MLX-interacting protein", "aln": "----------MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDDSDTDEPSPPPASGAATPARAHASAAPPPPRAG----PGREEPPRRQQIIHSGHFMVSSPHR------EHPPKKGYDFDTVNKQTCQTYSFG---------KTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSS---LVQDDDMLYWHKHGDGWKT---------PVPMEEDPLLDTDMLMSEFSDTLFSTLS----------------SHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMD------------------------------TFEPFQDLFSSSRSIFGS-----MLPASASAP-----VPDPNNPPA----------QESILPTTALPTVSLPD-----------------------------SLIAPPTAPSLAHMDEQGCEHTSRTEDPFIQP------TDFGPSEPPLSVPQPFLPVFTMPLLSP---------------SPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSVITHTASATLT-----HDAPATTFSQSQGLVITTHHPAPSAAPCGLALSP-------------VTRP-----PQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKRE----------GMLASTVSQSNVVIAPAAIARAPGVPEFHSS-----ILVTDLGHGTSSPPAPVSRLF-PSTAQDPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKS-DPKNVAALKNRQMKHISAEQKRRFNIKMCFDMLNSLIS----NNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHMKDMFDEYVKTRTLQNWKFWIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDP-AQLPEQASKAVTRIGKRLGES---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VID4-1", "uniprot_id": "Q9VID4_DROME", "id": "Q9VID4-1", "name": "", "aln": "MMLNKHEGYQRTSQMFPHQQHQLPQLHQQPYLQQSLCQNFQQLQYETGVGASASGSAEATADLLKAERESIHSGQFMVSHFEAEEAQDDLEDDGEVKMLDPEDPGLGKPGEPTNTCRDVQLYVPQTVAHFSAMDQEGDESSMSMVTSHLEIETSLTKLFKCMNLAYSQKLTSPKWNHFKGVRLRWKDKIRLNNVIWRCWHMQFIQKRRTPVCQFASPLD----VDIHSNPQTVVLEGKYWKRHSAVIKAEYRKWRRNYRSKATGCLTYDSKSELDFLEWSPLNDRNLMPDDWTTDTLFSAINVPFPFPDSREIARGAGIADFIQPSLGPLQPNLDDIDISFSDLIPTTRLPPVPEEGTDAEMLKNDEYCLSAIVGAPHTLYCNDSIMDVVNSSNNGAVNVDASMLELNTPINNVSYGEVEQRFSVARQVQQSNNDSQLLGDSGSMSGRIHGGKHFGPASANDNNTNRCVINGRVAKSTQRPFRREPHNYDKAQPTMHQTNLYQQMLAEQQKNQQQQHVVVSSFQASQQQQLAQQQPFSAQATNAFNNQSFISSYADNYQHQQQLNVKVEPLHADVLSLLNDNAYNSIGYKPYPQFKKSASTGTFLNVPRQTQQQQSYLQQEPPQMQQSLPVGMGNQQILQLTRQQQVNNTQQQQHQSTVASLLQQQHQQQNHQQQQLQTAVSSATWVSPNTILPKEIYRSNSLPLNVSLNKLPDGRQLHHEQPFAVPKYHSKSKSRVRSNSMHQQHTSVVSAAGAGSSSLGAHSCSNLLVTQQMQQATSDPMLNSTLAQLLTSNSRLQTAVANSSSSNSPSVSAIATTNSNSNAPPVHYANVTSPLSVPVPTHQHSPKKSASLPMAVNSALHSPPLGSKIHGIGLATANVGSNSLSLSPESTFHES-QDSPLSPTTSLKFQPRDTQRRAGHIHAEQKRRYNIKNGFDTLHALIPQLQLNPNAKLSKAAMLQKGADHIKQLRQERNVLKDKIEALRMERDELNNSLTHLHSILPANGAPVTRQGTEHVRQLYDIYVRYNTMNDWKFWILGLILEPLLASYTSTVSSASLDELRRTAFLWVDQHCSLIDLRPAVTNKLKYLSMHTDIVSEPPSTLQEEVAKALQNSSGQHPNLHGP", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::::* . :: . :. *: .: :: :: : : ...** * .: .* . ::* . * :::: ..*.. : .*. .*.:. *.: ** :* . :.**.*::******:**.**** **.****::***::*:*:*******.***.*:**:::**:.***:*.:*** ** * .*:::. ****** : :: **:*** ::.: * .* : : . : : *.*.* *.*: :. : . :::* :. :..*. :: * . : : * * : ..:: .* * :: .:: ** :*.: * :* . * . . . ..: : : .. * *. ::... .* * :::: :.* : :* : *.* * . .:.**. .*.. :* . : ** : *. .. . :*: ... * :.: *: :.*.: :: :. ... :** :. : * :*.::. : *. :: . . : : *:. * ..::: .:. ::.: ::: . * :: * ...:* :: :.:..*. : : : **. . *.. .. . .* . : .**. * . .* *. * . * :*. :* *:. . : . * . .:*: ** ******:**: *: *::**. * . *:* *** ::*.:*:*** :::: . ** * :*** :: :.:***.*.**. : :*:::::* **: . :::*****:.:*::**: *:.. **::**:*::***: *:****** *** * ..*: ** *.*:::* : * *:.::*: . . : : ", "identical_positions": 223, "similar_positions": 345, "identity": "19.84%" }, { "cls_id": "homologset.agr.HGNC:17056", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P47709-1", "uniprot_id": "RP3A_RAT", "id": "P47709-1", "name": "Rabphilin-3A", "aln": "MTDTVVN----RWMYPGDGPLQSNDKEQLQAGWSVHPG-AQTDRQRKQEELTDEEKEIINRVIARAEKMETMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETS-----NNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLP---QPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRAPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTTTRDSEGWDHGHGGGAGDTSRSPGGEQGLRRANSVQASRPAPASMPSPAPPQPVQPGPPGGSRAAPGP-GRFPEQSTEAPPSDPGYPGAVAPAREERTGPTGGFQAA-------PHTAGPYSQA-------APARQPPPAEEEEEEANSYDSDQATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNK---LRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P47708-1", "uniprot_id": "RP3A_MOUSE", "id": "P47708-1", "name": "Rabphilin-3A", "aln": "MTDTVVN----RWMYPGDGPLQSNDKEQLQAGWSVHPG-AQTDRQRKQEELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETS-----NNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLP---QPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAG---LRRANSVQAARPAPAPVPSPAPPQPVQPGPPGGSRATPGP-GRFPEQSTEAPPSDPGYPGAVAPAREERTGPAGGFQAA-------PHTAAPYSQA-------APARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNK---LRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2J0-1", "uniprot_id": "RP3A_HUMAN", "id": "Q9Y2J0-1", "name": "Rabphilin-3A", "aln": "MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPG-GQPDRQRKQEELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVET------NNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLP---QPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEARMSSSSRDSESWDHS--GGAGDSSRSPAG---LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSD---PGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNK---LRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G1U3-1", "uniprot_id": "A0AC58G1U3_DANRE", "id": "A0AC58G1U3-1", "name": "Rabphilin-3A", "aln": "MR---------RQNGAAFSDFTMTDAVMGTKGVHVQSG-PCLG-----AELTDEEKEIINNVIARAEKMEAMEQERIGRLVNRLDNMKKTVCGDGVSRCLLCGEQLGGAGDRAVVCEDCKKNMCTKCGVQT------NTRPRSVWLCKICSEQREVWKRSGAWFFKGLPKQFLP---SPMPISKPKERSPHQTPAAP-PVTMQTQAPVTAPEP-----------AVNPPIAPKP------PVAPKPAHLQTQSFSED---------GDPASPQNTPVM---MKKTVNVHAARPVSSSTAAGLESDR----------------GVYPPLS------------SGSADREELKS------------------VSPR----------VAQHQNAPSVDDDDEANSYDSDEATTLGSLEFTLLYDQGNSSLHCNIIKAKGLKPMDSNGLADPYVKLHLLPGASKSTK---LRTKTLRNTRNPTWNETLVYHGLTDEDMQRKTLRLSVCDEDKFGHNEFIGETRVALKKLKINQKKNFNICLERVVQTKRSSTAGGARGITLYEDETGKDGSELEERGRILISLMYSTQLGRLIVGVVRCVHLAAMDANGYSDPFVKICLKPDMGKKAKNKTQIKKKTLNPEFNEEFSYEIKHAELAKKTLDISVWDYDIGKCNDYIGGCQLGITAKGERLKHWYECLKNKDKKIERWHTLLNENHVSSD-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58GL58-1", "uniprot_id": "A0AC58GL58_DANRE", "id": "A0AC58GL58-1", "name": "", "aln": "MS---------RGKIAGRGGELRKKTVIIIIIIFIRTGCEMYGRQMETGELTDEEKQIINSVLERAKTMEAMEQERIGRLANRLDSMKRSACGDGYSRCLLCGQQFGLTGVSAVVCAECKKNMCTKCGVQS------VCRSGPIWLCKICCEHKEMLKQSGAWFFKGSPQQVLP---APLAISN---QRELSTSRTSTNPSANQQSPITSQTKN-AESVQVTGREQQISAETMP--------AKREERSVISQRALEEDGGRHRSTVQSDAAMEGQTFSPVVKREVPVQSSRPPASSFSTTPIQKDTMSRPEARAPPAMQADARLPAAN------------SVPASRQ----------------------------------------PPPPTTEDEEDANSYDSDDATTLGMLEFSLLYTEEKNELHCNIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNK---LRTKTLRTTLNPVWNETLVYHGITNEDMQKKTLRLSVSDEDKFGHNEFIGETRVVLKKLKLNQKKTYNVCLERVIPVRRTAGGGASRGMALYEEELKDD--EAEERGRILVSLTYNSQQGRLIVGVVRCAHLAAMDSNGYSDPFVKICLKPDMGKKAKYKTQIKKKTLNPEFNEEFSYEIKHGELAKKTLDVSVWDYDMGKSNDFIGGCQLGITAKGECLKHWYECLKNKDKKIERWHVLLNQSSVEADD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W2R9-1", "uniprot_id": "Q9W2R9_DROME", "id": "Q9W2R9-1", "name": "", "aln": "--------MDFQNRNNTANKFVCPSDRQLALRAKLKAG---WSSSKTSEPLRPEEQEAIISVIRRNEEIEVAERQRVGRLVERVEKIKQHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRYHTSERSREIWLCRICSETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPGSMAGDTRAVQSCHATPTRPARVKKLTIRVNDSSSSSSGHSEPEDEVDTG-VGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSIS----------DSSGSGSNNSG-----------------------------------NSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYGH-DFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQN-----------------WPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCLAPDNPAH---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . ::.* . * **:: * *: * : :* *::*:***.:*::.::: . * . * ***: :* ::* :*::.:****.*: * :***:** * :*: *:******** *: :* . .* : . : * . . : . . . : . * . . . . . . . . . ::.: : : . ** **::: * : .*.*.:::*:.* .**: ****** **:::. :::. ****::.* ** :**** : *: *:: .. : ::: *:**:** :*:* ::. *..:: ..: .: * .:. . .*::*:** *.:: *:*.: :* :* *** ** ******: **** *: * **.:* :**** :**** :: . :* *: * ::*** *:**.**::*. *** :*** *::* :*:: *: *:** * :. . ", "identical_positions": 153, "similar_positions": 168, "identity": "21.37%" }, { "cls_id": "homologset.agr.HGNC:17058", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5RKL7-1", "uniprot_id": "S35E4_RAT", "id": "Q5RKL7-1", "name": "Solute carrier family 35 member E4", "aln": "MCRCPLEHHEVRMTSAEAIAVAGSAQEHGRPKWPPDKPQVLGQPALARVVVAALVWLLAGASMSSLNKWIFTVHGFGRPLLLSALHMLAAAVACHWGAQRPVPHSIHRRVLLLSLTFGTSMACGNVGLSTVPLDLAQLATTTTPLFTLALSALLLGRRHHPLQFAAMGPLCLGAACSLAGELRAPPAGCGFLLVATCLRGFKSVQQS-ALLQEERLDAVTLLYATSLPSFCLLAGAALVLEAGAAPPLPPTDSRLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSHLSALSYVGIALTLSGMFLYHNCESVASWATRRGLWNRDQPGKGL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K3D6-1", "uniprot_id": "S35E4_MOUSE", "id": "Q8K3D6-1", "name": "Solute carrier family 35 member E4", "aln": "MCRCPLEHHEGMMTSAEAVAVAGSAQEHGRPKWPPDKPQVLGQPAPARVVVAALVWLLAGASMSSLNKWIFTVHGFGRPLLLSALHMLAAALACHWGAQRPVPHSIHRRVLLLSLTFGTSMACGNVGLSTVPLDLAQLATTTTPLFTMALSALLLGRRHHPLQFAAMGPLCLGAACSLAGELRAPPAGCGFLLVATCLRGFKSVQQSGALLQEERLDTVTLLYATSLPSFCLLASAALVLEAGTAPPLPPTDSRLWACVLLSCFLSVVYNLASFSLLALTSALTVHVLGNLMVVGNLILSRLLFGSHLSALSYLGITLTLSGMFLYHNCELVASWATRWGLWNRDQPGKGL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6ICL7-1", "uniprot_id": "S35E4_HUMAN", "id": "Q6ICL7-1", "name": "Solute carrier family 35 member E4", "aln": "MCRCPPEHHDGRMTSAEVGAAAGGAQAAGPPEWPPGSPQALRQPGRARVAMAALVWLLAGASMSSLNKWIFTVHGFGRPLLLSALHMLVAALACHRGARRPMPGGTRCRVLLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLGRRHHPLQLAAMGPLCLGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQS-ALLQEERLDAVTLLYATSLPSFCLLAGAALVLEAGVAPPPTAGDSRLWACILLSCLLSVLYNLASFSLLALTSALTVHVLGNLTVVGNLILSRLLFGSRLSALSYVGIALTLSGMFLYHNCEFVASWAARRGLWRRDQPSKGL", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***** ***: *****. *.**.** * *:***..**.* **. ***.:*************************************.**:*** **:**:* . : ******************** :********.********:***************:*****************:*:**:******.******:****** *********:****************.********.*** .. *******:****:***:*********************** **************:******:**:************* *****:* ***.****.***", "identical_positions": 291, "similar_positions": 40, "identity": "82.91%" }, { "cls_id": "homologset.agr.HGNC:17059", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ES21-1", "uniprot_id": "SAC1_RAT", "id": "Q9ES21-1", "name": "Phosphatidylinositol-3-phosphatase SAC1", "aln": "----MAATAYEHLKLHITPEKFYVEACDDGADDVLIIDRVS--TEVTLAVKKDVPPSAVTRPIYGIMGTIHLVAGNYLVVITKKMKVGEFFNHVIWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSTDGFYFSTTYDLTHTLQRLSNTSPEFQEMS-LLERADQRFVWNGHLLREL----SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSG------NRASFVQTRGSIPVFWSQRPNLKYKPDPQINKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFAKMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEM---QDELSYFLVDSAG---KVVTNQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDE-FEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLVMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELDS---HSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG--VASIGTFFIILYNGKDFVDAPRLVQKEKID-------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EP69-1", "uniprot_id": "SAC1_MOUSE", "id": "Q9EP69-1", "name": "Phosphatidylinositol-3-phosphatase SAC1", "aln": "----MAAAAYEHLKLHITPEKFYVEACDDGADDVLIIDRVS--TEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFSTTYDLTHTLQRLSNTSPEFQEMS-LLERADQRFVWNGHLLREL----SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSG------NRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEM---QDELSYFLVDSAG---KVVTNQDGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDE-FEKTYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELES---HSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG--VASIGTFFIILYNGKDFVDAPRLVQKEKID-------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NTJ5-1", "uniprot_id": "SAC1_HUMAN", "id": "Q9NTJ5-1", "name": "Phosphatidylinositol-3-phosphatase SAC1", "aln": "----MATAAYEQLKLHITPEKFYVEACDDGADDVLTIDRVS--TEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMS-LLERADQRFVWNGHLLREL----SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNG------SKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEM---QDELSYFLVDSAG---QVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDE-FEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELES---HSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG--VASIGTFFIILYNGKDFVDAPRLVQKEKID-------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1L244-1", "uniprot_id": "SAC1B_DANRE", "id": "A1L244-1", "name": "Phosphatidylinositol-3-phosphatase SAC1-B", "aln": "-----MASTYNSFNLHTTAEKFYIEACDDGVGDVLAIDRVS--TEKTLTVRKDVPPSAVTRPICGIMGTIRLVAGVYLIVITKKKKVGDLLGHAVWKASDFDIISYKKTVLHLTDNQMQDNKVFLSMLNSVLNTDGFYFATDYDLTHTLQRLSNTSPEFQEMT-LLERADQRFVWNGHLLREF----MAQPELHRFVFPVIHGFIAMRSCCINGKIFDWNLISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNG------AKASFIQTRGSIPFYWSQRPNLKYKPKPQISKSINHLDGFQRHFDSQIIIYGKQVILNLVNQKGSEKPLEQAFAKMVGSLGNGMIKYIAFDFHKECSRMRWHRLQILVDTVAEL---QDEFGYFLVDSDG---SVQMQQDGTFRSNCMDCLDRTNVVQSLLARRSLQSQLERMAVLHVGQRIEEQAD-FEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQWGLLMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYAVEEADM---NTPLHEPKDWKFLTLPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG--SASVVTGGVILFNGRDFVDAPRLVQKEKMD-------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A4VCH0-1", "uniprot_id": "SAC1A_DANRE", "id": "A4VCH0-1", "name": "Phosphatidylinositol-3-phosphatase SAC1-A", "aln": "-----MANAYERFNLHSTPEKFYIEACDDGADDVLVIDRVS--TEMTLAGIKDIPPSGITRPICGVMGTVRLVAGMYLIVITRKRKVGDLFGHTVWKAVEFDVISYKKTILHLTDIQMQDNKTFLTMINNVLNTDGFYFCTDYDLTHTQQRLSNTSPDFQEMS-LLERADQRFMWNGNLLREI----IAQPELHKFAFPVIHGFIVMKPCCINGKVFEWIIISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVQFNN------ARASFVQTRGSIPFFWSQRPNLKYKPKPLISKDTNHMDGLRRHFESQVLIYGKQVILNLVNQKGSELPLEQAFAKMVSSMENGFIKYIAFDFHKECSKMRWHRLQILVDAVSDM---QEEFGYFMVSSDG---KVLSEQSGTFRSNCMDCLDRTNVIQSLLARRSLQSQLQRMGVLHVGQKIEEQAD-FEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHWGLVMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDETDS---LTPLHVKKDWKFLLLPVIMVVAFSMCIICLLMAGDTWTETLAYVLFWG--MASALTAAVIVVNGREFVDAPKLVQKEKMD-------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0I6-1", "uniprot_id": "SAC1_DROME", "id": "Q9W0I6-1", "name": "Phosphatidylinositol-3-phosphatase SAC1", "aln": "MDSREENAVYDDMNLYIAPQSFIIEP--NGGDELLVIGRHDKVTRVQPASGGLVANLRPTRRICGVLGTIHLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIP-----NSFQRKENENYLRLLRQTLDTKFFYFSYRYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYVLRQF----NCD-KMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNG------QLTGFVQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAACGLHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREMGNPQVRYESFDFHSECRKMRWDRLNILIDRLAHE---QDQFGVYHVFDDG---KLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVNDNEGGAVPSPLESKHGWRFFTFPSVLLVAVAMFMITMTYPAEFNTENLLFMLFWG--AMIAVSATGILHYGVEFVQWPRLFPPISFRDP-----------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32368-1", "uniprot_id": "SAC1_YEAST", "id": "P32368-1", "name": "Phosphatidylinositol-3-phosphatase SAC1", "aln": "--------MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFN-----SRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKT-----ADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPN--LVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAP-LLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIK---SPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: : .: . : * . .. . * .::* ::* * :: . .* . ..:: ..::. . .:: :: ::. *. . ***. ****:: ** :.. : *::**.** : .:: : .:. * *:: *: :*. : :*:*** ***.* : ** *.:*:..** *****: .. .*:*****:*..* : **:*** : : : . **..* :**.: :**:::** * :: : :* : . ::* **** ** .*:*.*:.:*:* : . :::: : . * .: * ...*:**:********:**:**: * :: *: .*. *. : . ::. *****: : *:** *************: * . * ** *** **::** **** ***** : . . :*: : : :* :: .*.:: : . : *.. : * * : :. * :**: *:*. : ", "identical_positions": 153, "similar_positions": 177, "identity": "23.65%" }, { "cls_id": "homologset.agr.HGNC:1706", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P01731-1", "uniprot_id": "CD8A_MOUSE", "id": "P01731-1", "name": "T-cell surface glycoprotein CD8 alpha chain", "aln": "MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGS-VSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHP-TGTSQPQRPEDCRP--RGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICYHRSRKRVCKCPRPLVRQEGKPRPSEKIV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P07725-1", "uniprot_id": "CD8A_RAT", "id": "P07725-1", "name": "T-cell surface glycoprotein CD8 alpha chain", "aln": "MASRVICFLSLNLLLLDVITRLQVS------GQLQLSPKKVDAEIGQEVKLTCEVLRD-TSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLN--DILDPN-LFSARKE-NNKYILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGTPRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRRVCKCPRPLVK----PRPSEKFV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P01732-1", "uniprot_id": "CD8A_HUMAN", "id": "P01732-1", "name": "T-cell surface glycoprotein CD8 alpha chain", "aln": "MALPVTALLLPLALLLHAARP----------SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQ-PRGAAASPTFLLYLSQNKPKAA--EGLDTQ-RFSGKRL-GDTFVLTLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTT-PAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** : :* *** :::: * . ::*: *.* *:** . :.******: . . .***::*::..: * : *:.. **. : .:.::***..* :*:****** ***:**** .***: .:. * *. *.*:*. . :. . . *** *** *:*. **.************* * .*****:*** * **.*:********:*: * * : *", "identical_positions": 101, "similar_positions": 66, "identity": "40.24%" }, { "cls_id": "homologset.agr.HGNC:17060", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2K0P1-1", "uniprot_id": "A0A0G2K0P1_RAT", "id": "A0A0G2K0P1-1", "name": "", "aln": "------------------------------------------------------------------------------MTALISGGCGLFGPQWPFDDVPKAVTRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSLS-------------GKEKKEK-SSKPKDPPPFEGMEIDEVAN------------------------INDMDEYIELLYEDLPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKK-----------KAVDEDL-------------------------------------------------------------------------------------------ENQTLRKDYDKTFKKYQGLVVKQEQLLRGGFCLCQKVTPLCMCMSVRHSVFVHPPLLFALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKLKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISSDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPFLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQ-YLYGDDRIE---PYIHEGDILERPDLFYNSDGLITSEGALSPDFFNDFHLQNGDVVGQHSFPGSLGMDGFG---QPVGILGRPATAYGFRPDEPYYYSFGSR-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P70188-1", "uniprot_id": "KIFA3_MOUSE", "id": "P70188-1", "name": "Kinesin-associated protein 3", "aln": "----------------------------------------------------------------------------------MQG------------EDARYLKRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLSEVEQLLYYLQNRRDSLP-------------GKEKKEK-SSKPKDPPPFEGMEIDEVAN------------------------INDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKK-----------KAVDEDL-------------------------------------------------------------------------------------------ENQTLRKDYDKTFKKYQGLVVKQEQLLR-----------------------------VALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKLKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISSDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPFLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQLDESEQ-YLYGDDRIE---PYIHEGDILERPDLFYNSDGLITSEGAISPDFFNDFHLQNGDVVGQHAFPGSLGMDGFG---QPLGILGRPATAYGFRPDEPYYYSFGSR-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92845-1", "uniprot_id": "KIFA3_HUMAN", "id": "Q92845-1", "name": "Kinesin-associated protein 3", "aln": "----------------------------------------------------------------------------------MQG------------EDARYLKRKVKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSLS-------------GKEKKEK-SSKPKDPPPFEGMEIDEVAN------------------------INDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKK-----------KAVDEDP-------------------------------------------------------------------------------------------ENQTLRKDYEKTFKKYQGLVVKQEQLLR-----------------------------VALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQ-YLYGDDRIE---PYIHEGDILERPDLFYNSDGLIASEGAISPDFFNDYHLQNGDVVGQHSFPGSLGMDGFG---QPVGILGRPATAYGFRPDEPYYYGYGS------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LWL1-1", "uniprot_id": "Q1LWL1_DANRE", "id": "Q1LWL1-1", "name": "", "aln": "----------------------------------------------------------------------------------MQP------------DETQYLQRRCRIGDIDVHPTEKALVVYYEVEASILGETGNARHEEKKDCQKIIRLRSLNASTDISALAKKVVEECKLIHPSKLKEVEHLLLYLQNRKKPST-------------KLEKKEKKAQKPRELLLFEGMEIDEEAN------------------------INKIEEYIELLYESIPEKIRGSTLILHLARNPDNLEELLHNETALGALARVLREDWKHSVELATTIIYVFFCFSSFSQFHGLITHYKIGALCMNVIEHELKKYDLWQDELEKKS-----------KACDEDP-------------------------------------------------------------------------------------------DNHSLRKEHEKTFKKYQSLLVKQEQLLR-----------------------------VAFYLLLNLSEDTRTELKMRNKNIVHLLVKSLDRENEELLVLVVSFLKKLSIFLENKNDMAEMDVVEKLAHLVPCEHEDLMNVTLRLLHNLSFDTGLRTKMVHVGLLPKLTALLGDDTHKLVVMRILYHISVDDKSKSMFAYTDCIPQLMQMLFEHGEERIDTELISFCINLAANKTNSQIMCEGNGLKMLMRRALKLKDPLLMKMIRNISQHDGPLKQLFIDYVGDLAAQIKKEGDEEFVIECLGTMANLTIPDLDWELLLKEYNLVPFLKDHLKPGSAEDDMILEVVIMIGTVSMDDSCAVMLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKDTQAPAYLIDLMHDKNVEIRQVCDNTLDIIAEYDEEWGKKIQSEKFRWHNSQWLEMVESRQMEDGEP-YMYGDD-----------PEALEQPDLFYSTDGMMNPEPGISPDFYSQFHPQNGD------FNACNGSD------------GRPATAYGFRPDEPFFHGYGSTR----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VZ07-1", "uniprot_id": "Q9VZ07_DROME", "id": "Q9VZ07-1", "name": "", "aln": "MQFVLLLIFQIISGLVLLPIVIHYVYYIINAIAGDLCEQKRAQREQQLQRSPTPRHQNRHPPHPPPTEEEPVLSINNLTNSSRSPTAAATTTAMQTNDDAKFIKKRWKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDPAALAREVVEKCDLIHKSQLNDVEQIIFYLKNRKDNASNDIPDNNTHSRRSAALHTSHTRSSARSHSSVAAMTSSTGSGGGSTGASNGVSNALSAATPTADVSINNIDEYVELLYEELGERIRGSAMILQMARNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHPLIVQYKIGSLCMDVIDYELRRYETMRNELDVRKQPNGSSTPHSAKASKEKLNRSTDDFLDIMNEEKPKEMEPPRRRIPELKQRPKSGNWSSFHGSMSSSLIKSQILNSSYHESLCAGGSPGGDTPAVPAEQKAQSNESLDRNDPKVKKEEIDRLNKQLKIFAKKQEQLLR-----------------------------VAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNIDLLMLVSTFLKKLSIVGDNKDEMGALNIVAKLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMIAAGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQMATDAIILNLNVKVDLDLIALCINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHES-LQLQFIDYVGDLARILTICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCACDELCALLFCRAKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLMHDKNEEIRKVCDYCLDIIAISDSEWAKRIKLEKFRNHNSQWLCMVESQQDQDNEQDYADQEDECDNDLDTYLRSEYLDNCDLYNDNADNDSNSNSNHSNNNPASPAMSTYSRPLSTYRRSQDLDDLYNMTSSSKSQGSSDNNYIFKSNKSLDADGLHEELLMA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : .: : :: : *.*: **::***:* *::**:::** .:. *:*.*******:****.** ::**::***:*.*** *:*.:**::: **:**:. . :..: ...:. . .* . :. **.::**:*****.: :::***::**::********** **:.*.**:*******::*::*:*.***:*****::::** **.:****:***::*::**:::: ::**. :. ** .*. : : ::: :: *: : : ******* .*:*****::*:.: * ***.*:**::***:***:* :**:** :*******. :**::* :::* ** ::. . * **:::**:*: ***** *** **: .* ** *. ::.::.:: :.: :***:*:**: *.**: *:*: . :: : ::* :**::****: *: * *:: **: *: ** **:* :*.****::**:***:. : ********* :. :* *::**** :.**::.***:. :*::::*:*:::: * * : **::*:.:: :** : *: ** ::.:: :: :*****:*:*****:* ***:** *:: *::**: :**:*::.*********** ***:*** ***** *.**.*:*: **** ****** ****:* ::.* * :* : *:. **: .. . . . .: . : . . * * . . * *:.::. . ", "identical_positions": 326, "similar_positions": 276, "identity": "30.52%" }, { "cls_id": "homologset.agr.HGNC:17061", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q78J03-1", "uniprot_id": "MSRB2_MOUSE", "id": "Q78J03-1", "name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "aln": "MARLLRALRGLPLLQAPGRLARGCAGSGS-------KDTGSLTKSKRSLSEADWQKKLTPEQFYVTREKGTEAPFSGMYLNNKETGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAYGSKGSDESHTGILRRLDTSLGCPRMEVVCKQCEAHLGHVFPDG------PKPTGQRFCINSVALKFKPSKP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4FZX5-1", "uniprot_id": "MSRB2_RAT", "id": "Q4FZX5-1", "name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "aln": "MARLLRALRGLPWLEAPGR-ARGCAGSGR-------GDTGSLIKSKLSLSKADWQKKLTPEQFYVTREKGTEAPFSGMYLKNKETGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTKGSDESHTGILRRLDTSLGCPRMEVVCKQCEAHLGHVFPDG------PDPTGQRFCINSVALKFKPSKP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y3D2-1", "uniprot_id": "MSRB2_HUMAN", "id": "Q9Y3D2-1", "name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "aln": "MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDG------PGPNGQRFCINSVALKFKPRKH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NW52-1", "uniprot_id": "MSRB2_DANRE", "id": "Q6NW52-1", "name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "aln": "MSRFLVRLSTVVSKGATGKSVLPQKRIFAG--IRLISSSTGLQSLTRYDQSTDWQRKLSPEQYVVTREKGTEVPFSGIYLNHNEVGMYHCVCCDSPLFSSEAKYDAGAGWPSFCEAHGTWEKDESHANIVRRPDNSLGSTGTEVICKHCDAHLGHVFEDG------PDPTGQRFCINSVALNFKPREK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P25566-1", "uniprot_id": "MXR2_YEAST", "id": "P25566-1", "name": "Peptide methionine sulfoxide reductase 2", "aln": "MNKWSRLYVITVRRTFPGRRNIVLTQYWN-----------KSKKMSDESNDVKWNDALTPLQLMVLRDKATERPNTGAYLHTNESGVYHCANCDRPLYSSKAKFDARCGWPAFYEEVSPG-------AITYHRDNSLMPARVEICCARCGGHLGHVFEGEGWKQLLNLPKDTRHCVNSASLNLKKD--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : . : . . .*: *:* * * *:*.** * :* **: :* *:***. ** **:**: *: : ***:* * .. * : *.** . *: * :* .****** . *.. *.*:**.:*::* ", "identical_positions": 51, "similar_positions": 37, "identity": "27.13%" }, { "cls_id": "homologset.agr.HGNC:17062", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A1L1K8-1", "uniprot_id": "HABP4_RAT", "id": "A1L1K8-1", "name": "Intracellular hyaluronan-binding protein 4", "aln": "--MKGALGSPVAAAGAAMQETFGCVVANRFHQLLDDESDPFDILREAEHRRQQQLQRKRRDEAAAASGAGHRGGRSPAVASGHRPGAAGRRESQKERKSLAVSSAQQP-----DSPGG-PQPPGQKRTPRRGEQQGWNDNRGTDVVLDRAERRSYREYRPYDTERQAESTAEKFTDEKPVDRFDRDRPLRGRGGPRGGLRNRGRGGPGN-RAFDSFD-QRGKRDFERYGSSDK-ANRMEDSMGGCGVRTWGSGKD-TSDTEPPAPMEETSMMEECQGVLDEESASKVPELEVEEENQVQEMTLDEWKNLQEQTRPKPEFNIRKP----ESTVPSKAVVIHKSRYRDDIVKDDYED----ESHVFRKAAN--DITSQLEINFGNLPRPGRGARGSTRGGRGRIRRTENYGPRAE--------------------------------------------------------------------VVTQDVAPNPDDPEDFPALA----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JKS5-1", "uniprot_id": "HABP4_MOUSE", "id": "Q9JKS5-1", "name": "Intracellular hyaluronan-binding protein 4", "aln": "--MKGALGSPVAAAGAAMQETFGCVVANRFHQLLDDESDPFDILREAEHRRQQQLQRKRRDEAAAASGAGHRGGRSPAVASGHRPGAGGRRESQKERKSLAASGAQQP-----DSPGG-PQPPGQKRTPRRGEQQGWNDNRGTDVVLERAERRSYREYRPYETERQADLPVEKFTDEKPVDRFDRDRPLRGRGGPRGGLRSRGRGGPGN-RAFDSFD-QRGKRDFERYSSNDK-TNRMEDSMGGCGIRPWGSGKD-TSDTEPPAPMEETSMMEECQGTLDEESAAKVPELEVEEENQVQEMTLDEWKNLQEQTRPKPEFNIRKP----ESTVPSKAVVIHKSRYRDDMVKEDYED----ESHVFRKAAN--DITSQLEINFGNLPRPGRGARGSTRGGRGRMRRTENYGPRAE--------------------------------------------------------------------VVTQDVAPNPDDPEDFPALA----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5JVS0-1", "uniprot_id": "HABP4_HUMAN", "id": "Q5JVS0-1", "name": "Intracellular hyaluronan-binding protein 4", "aln": "--MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDEAAAAAGAGPRGGRSPAGASGHRAGAGGRRESQKERKSLPAPVAQRP-----DSPGGGLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEKPGDRFDRDRPLRGRGGPRGGMRGRGRGGPGN-RVFDAFD-QRGKREFERYGGNDKIAVRTEDNMGGCGVRTWGSGKD-TSDVEPTAPMEEPTVVEESQGTPEEESPAKVPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKP----ESTVPSKAVVIHKSKYRDDMVKDDYED----DSHVFRKPAN--DITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAE--------------------------------------------------------------------VVMQDVAPNPDDPEDFPALS----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5XJA5-1", "uniprot_id": "HABP4_DANRE", "id": "Q5XJA5-1", "name": "Intracellular hyaluronan-binding protein 4", "aln": "--MK-------ELVEEMPDEGYGCTVANRFGQLLGDESDPFDILYAAGTEKKQ---KKKKEEPKKTS----------------TTTKSVKKESQRDRKTILP------------AGGG-----GQVRP-------------GHEVVEEPIQRRVTFDRKFNDAEK----PPLSFSVERPVDVLDR--PARGRGTGRG----KGARGPGFPRSNDGFD-QRGKREFERHSGSDRSSVRSEEKRSGSGSRNWGSVRDHMSVIEVASPSEEVTENEETQEAVETDGENRPSETEEVIEV-AMEMTLDEWKALQEQSRPKVELNIRKT----ESSVPSKAVVIHKSKLLQ---KQDGMD----EDVVFRRPAN--DITCQLEFNFGSLDRPTRGGRGG-RGGRG--RGGPSMPTLRS--------------------------------------------------------------------PQKFDSAPNPDDPEDFPALA----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V426-1", "uniprot_id": "Q9V426_DROME", "id": "Q9V426-1", "name": "", "aln": "MDSAGKNRYELLFMDDDVSDPLDNLVAPTAAAAAAAAGKKKQPSAAAAAATKTTANKVANSNNKANAGSNIGGPNAKKPNQAEKENKPNNALNKTDGKKFTPSADNKQQQFNNNASSNYKQQGAPRQGGGANRTREFGSGQGQGQGQGGQQQRSVNFRQQNGNAETREQRNNRRNVRENVGAPDGQQSRPYRGPGGG----PGAGGDRPQRQNRNYDGQNRKREFDRQSGSDRTGVKSIDKRDGAGSHNWGSVKEAIDDVNKNESETNVTNAEG--GAKADESGTEPQNEQATAEEEAKELTLDEWKAQQGQ-RIKPTFNIRKAGEGEDTTQWKKMVVLTSNKKKENDSEEELEY----DPALYPQRVGRQQRVLDIQFNFNDGRRGGPGGFGGRGGRGGPRPGGFGGGPRSEGGNRDGGNREGGRDNREGGNRGPRDGQQHNNEGGGSSAQNQRPPIDRRGPGNNQNNNQNSGPGPNKRFERQQNTAPKVNDERQFPTLA----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VXX1-1", "uniprot_id": "Q9VXX1_DROME", "id": "Q9VXX1-1", "name": "", "aln": "----------------------------------------MNVPLVALTKDPKMKKSQKKSS-----------------------MVAVPKMSQKPQK-------------------------------------------AARLFQPKVENKITLTTPLTAPKK------ERVKDIKVADPLEKEVESVFVTVPKN-------------KLCKTRRNRPGDRLFDRRSGSKRTGVKAVEKRNGAGAHNWGSIQQEIDLRQR-------TNLRTFEGMKLPKVSSFVYEYDS--SEETEQYTLDEWRAMQAQKKQVLNKFIMSDFGTKKEVTGGSEETVRAEGSGDTDDTKGLDKTGGTEQTGNTETGERSAGSGETETAAASGVPDASGGSGGTEGSGGLGGSGELEDDGEE--------------------------------------------------------------LTADRPLYVVDILLNFNTDQGVIPYRLKFI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * ... .: * . :.: . . . : . : : .* *:* ....: : :. .*.* : *** :: . : : . . : : . . : *****: * * : * . . . .: . : . : . : : . *. *. * * . : : : . . . ", "identical_positions": 22, "similar_positions": 66, "identity": "4.36%" }, { "cls_id": "homologset.agr.HGNC:17063", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P69735-1", "uniprot_id": "RB3GP_RAT", "id": "P69735-1", "name": "Rab3 GTPase-activating protein catalytic subunit", "aln": "MAADSEPES----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVGCPLTPLPPVSIAIRFTYVLQDWQQYFWP---QQPPDIDALVGGEVGGLEFG---KLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGR-VADITHALSKLTEP-APVPIHKLSVSNMVHTAKKKIRKHRG-EESPLNNDVLNTILLFLFPDAASEKPLDGTTSVDNSNPAAEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSPSDSMTKAYPADAGKAGGQLGLDHLRDTEKEKGEAGKSWDSWSDSEEEFFECLSDAEDLRGNGQESTKKGGPKDMAPLKPEGRLHQHGKLTLLRN-GEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCCLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEES-LENIPSVKKIIKQIIAHSSKVLRFPSPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKED--LERFVSCLLEQPEVAVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKRSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80UJ7-1", "uniprot_id": "RB3GP_MOUSE", "id": "Q80UJ7-1", "name": "Rab3 GTPase-activating protein catalytic subunit", "aln": "MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGPSLGKPLEKGIFTSGTWEERSDEISFADFRFSVTHHYLVQESPDKERKDEELEDAIPQS--MQDLLCMNNDFPPRA------HCLVRWYGLREFVVIAPA-AHSDAVLSESKCNLLLSSISIALGNTGCQVPLFVQIHHKWRRMYMGECQGPGVRTDFEMVHLRKVPSQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRLTYVLQDWQQYFWP---QQPPDIDALVGGEVGGLEFG---KLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGREVADITHALSKLTEP-APVPIHKLSVSNMVHTAKKKIRKHRG-EESPLNSDVLNTILLFLFPDAVSEKPLDGTTSIDNSIPAPEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGSPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSLSDSTTSAYPGDAGKTGGQLGLDHLRDTEKEKGEVGKSWDSWSDSEEEFFECLSDTEDLKGNGQESGKKGGPKEMANLKPEGRLHQHGKLTLLHN-GEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCFLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEES-LENIPSVKKIIKQIIAHSSKVLHFPNPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKEG--LERFVSCLLEQPEVSVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKKSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15042-1", "uniprot_id": "RB3GP_HUMAN", "id": "Q15042-1", "name": "Rab3 GTPase-activating protein catalytic subunit", "aln": "MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEEKSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQS--MQDLLGMNNDFPPRA------HCLVRWYGLREFVVIAPA-AHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGECQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQQYFWP---QQPPDIDALVGGEVGGLEFG---KLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADITHALSKLTEP-ASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD-VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHN-GEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHLLPCVIHAAVLKVKEEES-LENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQEEEKED--LERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NUV0-1", "uniprot_id": "RB3GP_DANRE", "id": "Q6NUV0-1", "name": "Rab3 GTPase-activating protein catalytic subunit", "aln": "MAADSDPESEVFEITDFTTASEWERFISRVEEVLNDWKLIGSRVGKPLEKGEYTSGTWEESSQEISFADFKFSITHHYLKQESAENDGRDELEEDAYPLA--MQDLLCINNDFPPRA------HCLVRWFGVREFVVISPG-ANCEAIISESKCSLLLSSVSIALANTGCQVPLFVQIQQKHRKMFSGECQGPGVRSDFEMVHLRRVPSQYNHLSGLLDIFKNKIGCPLTPLPPINISIRFTYVLQDWQQCSWP---QQPPDFDALLAGEVGGVEFG---KLPFGACEDPISELHLAATWPSLTEGIVVDNDVYSDLDPLQAPHWSVRVRTAENPQCLLGEFLTEFFKICCRKETTEEILGRSTAEEEGKENSDITQALSKLTEPSTAVPIHKLSVSSMVHSARKRIRRHRRVPESPLNNDVLNSILLYLFPDAALDKADVSEVRPPQQSPDRQSEDYHLYNQLKSCPSDSLTHRLALCICMVNFHHGGVRAVAHLWQEFVLEMRYRWENNCLIYGLASGPPDLRCCLLHQKLQMLNCCIERKKARDDGKKSSSSDGARDRSRGAPEGAG--------PEGAGPAEAAGKSWDSWSDSEDEFFECVSDTEEMKEDKEEAENRSRSK------PEGRLQPHGTHTLLNT-QEPLYIPITQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCTLLDFVRWYSPRDYVEEQVTDADGRVEVRGELSARMKIPGNMWVEAWETARATPARRQKRLFDDTKEAEKVLHYLALQKPSELTRHLLPCVLHAALLKIKEEES-AEDLPSVRSSLQQISSSASKILRHPNPEFKKLEDVISQLMAVEAVIARARSLKAKFGVCGGEREREEDGDELERFVSSLLEEPEVCVSGAGRGPAGNVIHKLFVSSQRAALLAPMEEETLRSGGSDDRK--AFPDFPPPAGREILLRTCVPRPAPYSKALPQRLFCVLMRDEFRLAGAFSSDTSFF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQ26-1", "uniprot_id": "RB3GP_DROME", "id": "Q9VQ26-1", "name": "Rab3 GTPase-activating protein catalytic subunit", "aln": "--MAEEIDDNEFYRENFSADSDWEVFNAQLGEILQKWDVSSDSETRNLKSEEIFSCNWKVEREKLDMLRNGIEVEYHQAILEDEELVRAEAKEITCLQRTSCHHDLMSTGNSFGPPIRSSQELHILARIYGLRRFIVLHPVNPTLNYMRSTSEFNFFLSAVAVVSAEVQSLVPIFVQIYDPKWNYYTGVALAPALRTNFRLIGLEKAPPECRFLMGLLTLFREKVPTSYTQAAMISVCTTYALDTMRIRMPMYVPFDHGLSSEDIVVDGEVSHLEVQQFCALPHGYKPESRTEIYLVYTWPELSEHVAFDSEQRSDFVPAKAPLGKIYLSVEASS----------YLSCCLRDYQSVAEVTRSLESFVGRNFSGTSSGAEAASNPLDRITEHKLTKRRERSFELPSQAGLTKRLPGPMTESELSELLAYLFPDMHPEMALFPYAKKNFTDKFDP-------MRIKSAVPDSLVCRLSCLLATCHAHLGSVEGMAQVWAAFTRQLRLLWDNSLMVPGISAGFPDTRTCLLHQKLQMLNVCVERRVQREANSKRKSEGMVGKASSEEE--------------------------EDEDDDEGEFFDCDDLTAGAG---------SPTKAVLSLKPEGRLRRLNNERLLEEPDEYLYIPDTQEPVPKTEDQLQDDAEVMLKLGP---GSGLTTQMMCTSLLSDMEAFKAANPRGIMEDFIRWYSPKD--WEEVTDELG--QVKHQLSIRMTTEGNTWQKVWEQAQAVPVSRQKRLFDDTNEALKVLHYLETRKMHEIYNLTVIPLLHSAILKLADILSNAELEDLFSSQIEKLLSDLCRLSRSHSDELPSIKPLLDDLAELERRFYQFKCFERLSGYPKRSS-----------LQQVKLQFEEILRNDNCCTIVNRRLTAAGDGTLYDILIPKLEEDMADRLISKDYIIRLDGDTKTTEKGLYLG--------------PQFMRAIVTGEKLRLCGAFTESTAFV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: :. :: . * . :.:. : : : : .. * :: ***. :*. **.* :. :*::*. *** *:* : .*.: **: * :** .: : .. ::. * *. : : ** . *: :. : . . ::* :. ***: .*:... *. :* :**** : . . ::**. .***. :*: :. : : *.:..:*::* *. ::* *:*. :: *:::* ** * *********** *:**: *: ..* . .. . :. .*.* ***:* . : . .* ***** .. **. * **** ****.* *** *::::**: ***. *: * ::* .:.******:****** : **:*****:* *:* * * :: :** **. .* * :.** *:. *. **:******.** ****** :* :: . : ::*:*:**: : * * . . :::: : .:: : . * .:: :: :: :* : : :.:: * . : . *: *: .. ... : .: :. **: ..: * .. : ** : .:: :.:**.***:..*:*.", "identical_positions": 182, "similar_positions": 222, "identity": "18.16%" }, { "cls_id": "homologset.agr.HGNC:17064", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LKZ7-1", "uniprot_id": "A0ABK0LKZ7_RAT", "id": "A0ABK0LKZ7-1", "name": "", "aln": "-----MAAGGAAGLREEQRYGLACGRLGQDNIT-VLHVKLTETAIRALETYQSQKSLIPFQPS----IQFQGLQGLMKIPK-NDPFNEVHNFNFYLSNVG-------------KDNPQGSFDCIQQTLSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAISDAVPERKRSTPMNPANTIRKMHGGSS----------------------------------------------------------------------------------------------------------------------------------------------------------VSQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNPKDLSYTLKDYVFKELQRDWPGYSETDKQTLDLVLSRKLNPSQNAG-TSRPESPMCSSKDAASSPQKRP----------------------LDSDFIDPLTNKKARISHLTNRVPPTLNGHLNP-------TNEKSCASLLPPPAAAAIPTPSPLPSTHLPVSNPTQTVNSNSNSPSTPEGRGTQDLPVDSFSQNSSIFE------------DQQDKYTSRTCLEETLPSSSALLKCPKPMEEEHPVSHKKS--------------------------------------------------------------------------------KKKSKKHKEKDQIKKHDIESREEKEKDLQREE-TAKLSNDSPNP-----NEGVKEECTASMEPSSTIEL----------------PDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRK---RLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIVDVCNHK-------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UKU1-1", "uniprot_id": "ELL2_MOUSE", "id": "Q3UKU1-1", "name": "RNA polymerase II elongation factor ELL2", "aln": "-----MAAGGAAGLREEQRYGLACGRLGQDNIT-VLHVKLTETAIRALETYQSHKNLIPFRPS----IQFQGLQGLMKIPK-NDPFNEVQNFNFYLSNVG-------------RDNPQGSFDCIQQTLSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAISDTVPERKRSTPMNPANTIRKMHSGNS----------------------------------------------------------------------------------------------------------------------------------------------------------VSQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNPKDLSYTLKDYVFKELQRDWPGYSETDRQTLDLVLSRKLNPSQNAS-TSRSESPLCSSKDAASSPQKRP----------------------LDSDFIDPLMNKKARISHLTNRVPPTLNGYLNP-------TSEKSCAGLLPPPAAAAIPTLSPLPSTHLPVSNPPQTVNSNSNSPSTPEGLGTQDLPVDSFSQNGSIFE------------DQQEKYTSRTCLET-LPPSSALLKCPKPMEEEHPVSHKKS--------------------------------------------------------------------------------KKKSKKHKEKDQIKKLDIETMEEKEEDLQREE-TAKLSNASPNP-----NEGVKEGCTASMEPSSALEL----------------PDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRK---RLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWH--------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O00472-1", "uniprot_id": "ELL2_HUMAN", "id": "O00472-1", "name": "RNA polymerase II elongation factor ELL2", "aln": "-----MAAGGTGGLREEQRYGLSCGRLGQDNIT-VLHVKLTETAIRALETYQSHKNLIPFRPS----IQFQGLHGLVKIPK-NDPLNEVHNFNFYLSNVG-------------KDNPQGSFDCIQQTFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSSST----------------------------------------------------------------------------------------------------------------------------------------------------------ISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPSQNAAGTSRSESPVCSSRDAVSSPQKRL----------------------LDSEFIDPLMNKKARISHLTNRVPPTLNGHLNP-------TSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYE------------DQQDKYTSRTSLET-LPPGSVLLKCPKPMEENHSMSHKKS--------------------------------------------------------------------------------KKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNS-----SGGVKEDCTASMEP-SAIEL----------------PDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRK---RLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWS--------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R2K7-1", "uniprot_id": "F1R2K7_DANRE", "id": "F1R2K7-1", "name": "", "aln": "---------MMAALCEDGTYGLNCGRK-SDKIS-VLHVKLTESAFKALESYQNCKNAPSTQAT----IRFQGLQGRIKIPT-TEASDGSHNFNFYLSNFG-------------KDNPQGSFECIHQYISSSGIPHLSSLGTIQDKITVCATNDSYQVTKERVTKAEEDKSKNSTKFIKPGGPFRDKKIHRKPAPSAP-DPVPERKQTTPLNPANTIRKCLTNNP----------------------------------------------------------------------------------------------------------------------------------------------------------VSQKPYRDRVIHLLALRSYKKLEVLARLQRDGVSQKDRNSLGTTLHQVANLNPKDNSYSLKDFIFREVQRDWPGYTEDDRVQVDRILARKLGLN------LESVSSNSPTKEPTS-PLKRQ----------------------PETDFIDPLMPKKPRISHLSNRGPPSSSRHPSE-------TEDK------KPAPTVACPGPS-FP--------PPPVTGSSSNSPSTPEGLGSQDLPLDQSSICGNSSESYAPRSQTPSPPNQPASTTSPSSFST-CTVSTTTITSTTTTSGSHQVSSAASP-----------------------------------------------------------------------TDDSGSKKPKKSKKHKDKEKKREGEREKEKDRERKRDREHRKEDLADKDAQPRKKHRSEAEQKHIPANISHDSDREAGKEKPVNSTELPAPTKPDYISKYTAVISMDQRQHYKDDFNGEYDEYRILHARVESVTRRFTKLDAQCR---RLAPGTKEYQEVHEQVLQEYKKIKQHSPNYYEEKQRCEYLHNKLAHIKRLIADFDQRRAQSWL--------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VW51-1", "uniprot_id": "ELL_DROME", "id": "Q9VW51-1", "name": "RNA polymerase II elongation factor Ell", "aln": "MTNSIASTKCLPNALSTGNYGMSQSHRYTDDSKEYIIVKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTGVIQFPRPATDANGIPNANGNGSDATGAGGGGGRKFGFTINNMEGTLECVQQQQRS-----LGVLGAVTLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKVKKPPSAIQSSASTASAFSSNSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSSSAFASRSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGTSSATASSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAFKKPELFARLKNEGIRDRERNQITNILMDISTMSHN--TYNLRRQMWNDVDENWPFFSEQEVQQLKRRKPQNLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMFSTVQPKKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYNVLDNIVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSGYETQQDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNNAQHVASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQQNQHQKQQVQQKQAPSQQQQQQQQQYHQQAKHPSPSQQLAAAAHAYAHATADTDSSATP--------------RYDFSQYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQIVCEYERINNDR-TIGEDKERFDYLHAKLAHIKQLVMDYDKTLMSATMAMAPTDVVAAQGPDPAVAKAAARLAEHHRRQHHAAETIKQQQQQKQTHQHHLQRHLQHHLQQQQNLLQQQQNLLQQQSVSNSDDSSDSSDSNDDDDDDDEDCDDSNSNTDDDEARY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . **: .: *. . : ****::*::*:* ** .. :. *:* * * :::* : * * *: :* :*:::*::* * *. ** : :: : *.:* *: *: ::: *** . ... : ***. . .:::: :. .... :.. *.. * . :*:: *:*:******:::** *::***:.:*: ::::*.: * :::.:. : :*.*: ::.:::.:** ::* : :. .::* . . .: .. * * : ::..: ** **** .: **: . : . :. . *. . * . .*.:.:* :. *: * .. * . :: . * :. . .... . .: : : .*:.:.. :: .: : : :::: .::. . . ..: . . * : . : :* .: : : *:.** :*:.:***** * :*:* * .** .*. : . * * :*:.::.::: **::*:: . *:* * :*** ******:*: : : ", "identical_positions": 120, "similar_positions": 229, "identity": "11.1%" }, { "cls_id": "homologset.agr.HGNC:17066", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9PST5-1", "uniprot_id": "E9PST5_RAT", "id": "E9PST5-1", "name": "Apoptotic chromatin condensation inducer in the nucleus", "aln": "MWRRKRPNSSGGTRGILSGNRGVDYGSGRGQFGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMTHP------EGVASLLPPDFQSSLDRP----------ELELSTHSPRKSSSFSEEKGES-------------------DDEKPRKGERR------------------------------------------SSRVRQAR-AKLPE-------------------------------YSQAAEEEEDQETPSRNLRVRADRN-------------LKVEEEEEEEEEE--DDEEEEEEVDEGQKSREAEAPILKQFEDEDGEEMTRAKPEKVVDEKPPIIRSQE---KDELEKGGRVTRSQEEARRSHLARQQQEKETQIVS-LPQEENEVKSSQGLEEKSQSPSLPPLPEDLEKAPVVLQPEQIVSEEETPPPLLTKEASSPPT----------------------------HMQLQDEEEVEPAEGPAPPVLIQLSPPGTDAGTREPIVS---------------------------------------------------------------------------------------------------------------------------------PHTVQLLRGLSPLSSTADTKAESPAERVSEESVLPLAQ-RSILPEHSAQKG-----------------------AESEREKSAPLLPLTREELAPAKGITEESVKKQSLEQEEGRRASHTLFPDHS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKPSADSSSSR----------SSSPSSSSSRSRSRSPDSSASRSQSSPRSKQREVSQARVHANPHDRAKMGS--------RSTSESRSRSRSRSRSASSGSRKSLSPGVSRDGNTT-------YTETKDPSCGQEAAAPSVPQLQVLEPKEKAPTCSASVRGRHMSQPEPE--QKHVIQRLQPEQESPKKCEAEEAEPPAATQPQTSEPQLSQLPEAERTPHTAEEKEDVTMDTSEN----RPENEVPEPPVP------------------------IADQVSNDDRPEGSAEEEERK-------------------------ESSMPKSFKR-KISVVSATKGVQAGNSD-----TEGGQPGRKRRWGASTAATQKKP-SISITTESLKSLIPD-IKPLAGQEAVVDLHADDSRISEDETER---NGDDGTHDKGLKICRTVTQVVPAEGQENGQRE-------------EEEE-KEPEAEPPAPPQASVEAALPPP-VEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEA-FWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELD----YHRGLLVD-RPSEAKTEEQGAPRPLHPPPPPPVQPPPHPRAEPREQER-----AVREQWAEREREMERRERTRSEREWDRDKVREGP-----------RSRSRSRDRRRKER---AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTESQIVQKEAEQAERAKEREKRRKEREEEEQKEREKEAERERNRQLEREKRR-EHSRER--ERDRERERDRG---DRDRDRERDRDRGRERDRRDTKRHSRSRSRSTPVRD----RGGRR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JIX8-1", "uniprot_id": "ACINU_MOUSE", "id": "Q9JIX8-1", "name": "Apoptotic chromatin condensation inducer in the nucleus", "aln": "MWGRKRPNSSGETRGILSGNRGVDYGSGRGQSGPFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMTHP------EGVASLLPPDFQSSLNRP----------ELELSTHSPRKSSSFSEEKGES-------------------DDEKPRKGERR------------------------------------------SSRVRQAK-SKLPE-------------------------------YSQTAEEEEDQETPSRNLRVRADRN-------------LKIEEEEEEEEEEEDDDDEEEEEVDEAQKSREAEAPTLKQFEDEEGEERTRAKPEKVVDEKPLNIRSQE---KGELEKGGRVTRSQEEARRSHLARQQQEKETQIVS-LPQEENEVKSSQSLEEKSQSPSPPPLPEDLEKAPVVLQPEQIVSEEETPPPLLTKEASSPPT----------------------------HIQLQ--EEMEPVEGPAPPVLIQLSPPNTDAGAREPLAS---------------------------------------------------------------------------------------------------------------------------------PHPAQLLRSLSPLSGTTDTKAESPAGRVSDESVLPLAQ-KSSLPECSTQKG-----------------------VESEREKSAP-LPLTVEEFAPAKGITEEPMKKQSLEQKEGRRASHALFPEHS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKQSADSSSSR----------SSSPSSSSSPSRSPSPDSVASRPQSSPGSKQRDGAQARVHANPHERPKMGS--------RSTSESRSRSRSRSRSASSSSRKSLSPGVSRDSNTS-------YTETKDPSCGQEAAAPSGPQLQVLEPKEKAPTFSASVRGRHLSHPEPE--QQHVIQRLQPEQGSPKKCEAEEAEPPAATQPQTSETQISHLLESERTHHTVEEKEEVTMDTSEN----RPENEVPEPPLP------------------------VADQVSNDERPEGGAEEEEKK-------------------------ESSMPKSFKR-KISVVSATKGVQAGNSD-----TEGGQPGRKRRWGASTAATQKKP-SISITTESLKSLIPD-IKPLAGQEAVVDLHADDSRISEDETER---NGDDGTHDKGLKICRTVTQVVPAEGQENGQRE-------------EEEE-KEPEAELPAPPQVSVEVALPPP-VEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEA-FWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELD----YHRGLLVD-RPSETKAEEQGAPRPLHPPPPPPVQPPPHPRAEQREQER-----AVREQWAEREREMERRERTRSEREWDRDKVREGP-----------RSRSRSRDRRRKER---AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTESQIVQKEAEQAERAKEREKRRKEREEEEQKEREKEAERERNRQLEREKRR-EHSRER--ERDRERERDRG---DRERERERDRDRGRERDRRDTKRHSRSRSRSTPVRD----RGGRR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UKV3-1", "uniprot_id": "ACINU_HUMAN", "id": "Q9UKV3-1", "name": "Apoptotic chromatin condensation inducer in the nucleus", "aln": "MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHP------EGVASLLPPDFQSSLERP----------ELELSRHSPRKSSSISEEKGDS-------------------DDEKPRKGERR------------------------------------------SSRVRQARAAKLSE-------------------------------GSQPAEEEEDQETPSRNLRVRADRN-------------LKTEEEEEEEEEEE-EDDEEEEGDDEGQKSR--EAPILKEFK-EEGEEIPRVKPEEMMDERP-KTRSQE---QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPP----------------------------HPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVS---------------------------------------------------------------------------------------------------------------------------------QHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQ-KSTLADYSAQKD-----------------------LEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKQSADSSSSR----------SSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGS--------RSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTS-------YTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESA--EKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSEN----RPENDVPEPPMP------------------------IADQVSNDDRPEGSVEDEEKK-------------------------ESSLPKSFKR-KISVVSATKGVPAGNSD-----TEGGQPGRKRRWGASTATTQKKP-SISITTESLKSLIPD-IKPLAGQEAVVDLHADDSRISEDETER---NGDDGTHDKGLKICRTVTQVVPAEGQENGQRE-------------EEEEEKEPEAEPPVPPQVSVEVALPPP-AEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEA-FWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELD----YHRGLLVD-RPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER-----AVREQWAEREREMERRERTRSEREWDRDKVREGP-----------RSRSRSRDRRRKER---AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRR-EHSRERDRERERERERDRG---DRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRD----RGGRR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1Q511-1", "uniprot_id": "F1Q511_DANRE", "id": "F1Q511-1", "name": "", "aln": "----------------------------------------------------------MAELEDVTLDGKPLHSLRVADLKTALEERGLAKSGQKNALIKRLKGALMLENLQRSSTCHSGIQPNSQIGEEMSQNSFIKQYLAKQQELLRQRLEREAREATEADESQSPAGPEEDD------NDSTSFLLEKHHIAHAHLSAGGGLPQ---DPGLVGSQKLDTGPVPVSQES--------------------SDSKAG-------------------------------------------------RIWHPSFP--------------------------------------SGHEDVATPSPPRAVASLSVR------------------VVGQPERQGLPPRSQEREGTAPVEAGPAHSMLQLSRSARAAG--------GAQVDSDD----------DDDEEDDDDSEDDDEWGPASHGKKNVRAPPARAPPAAAPQRSRRKLQPPQHIPPQLQP-------------VLQPPLQL-RQPTPPPSPPPELSFPLP----------------------------DTPKQSPHDQDEPAGLAEAAVPGPGMVSPPSLTRQ------------------------------------------------------------------------------------------------------------------------------------ESSSSSRSSSPEPPSTRKPGPLSLLVRKMESEGVFGSAQNIEVKGEGDMEVE-----------------------EQEHSEAAVQDSTRELSRTDVSSSVSTMPPDQQGIQDSELEKGEDE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKPSEETQ-------------NEKVDETSVPLCSTSTTTRSSRRQRIFSEVPPPESLMSPS-----KPEQLS-----MLTSISKGS-------EDSPMETEEFTTTPASKHKEDKE--------LKGLNNEAPEESPKPADENKKALT----SPHATSEEEKMDKTRDRSK---KDKRRSSTSSQSSSSDADSESSSSHSSSSPSRDKSSPTS-KTKDVEEKGRKGAEEKKAQSSRE----VKQEALSEPTG------------------------QVAMELEGLSHSESAVQQSDHQGADSSDSRP---------------EESSAAKSFAARKISLSS---KTEIASSE----SEPVGGASRKRRWGSSTAVTAKKP-SISITTESLKTLIPD-IKP--LQEAVVDLHPDEGRLSVDEDSSGPREREEPEEDQGLKIRRTVTQIVPSDGHENGQKEMDEKDEEEDEDDEEEEQKHSGEEKEKPRKQESSP-DASVETPECDSQKVTPSDSLVRRSISQQKSGVSITIDDPIRTGRQLSPPRGKTSNIIHVLHLVRPFTLGQLKLLLNRTGTMVEEG-FWIDKIKSHCYVTYSTVEEAVATREALHGVKWPASNPKVLRVDFSDQDELD----FHKGLISGERAGVGHDPKASGPSSRPPAAHPPIPPPNHEKEKERERDRDGGSSAVRDQWAERERAMERRERTRSEREWDRDKVKDFG-----REERDRTRRSRSRERRRRER---GKSKEKRTEKKEK-PEEPPVKLLDDLFHKTKAAPCIYWLPLTDEQATQRDQERADRIKEREKRRKEIFEEEDKKRK-EREQERAKGRDRVGGNTAETRAGVPRRSTEGERDRGKGGERERGREADKRKDAQRGQRDSKTTTAAGNRRSQSHN-STSRDRRH", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2BIJ9-1", "uniprot_id": "A0A8M2BIJ9_DANRE", "id": "A0A8M2BIJ9-1", "name": "", "aln": "----------------------------------------------------------MADLEDVTLDGRPLHSLRVADLKAALEERGLPKSGQKNALVKRLKGALMLENLQKTSTPHIGLQPNSRIGEEMSQNSFIKQYLAKQQELLRQRLEKEAREAAETDGTDRGDHTESNDNIHAASNQDVASSLVDQNQGSAAVAGGFGVTESESEKEMPGQPSLSTAAHSRPRASSVRLRGKGEPTSSHVPAESDDDSEAGDDEEEEEWNARPQRSRRAQPPKSQPVRTRSSGSQQQQQPPPQHIPLLSQQLRHPTPPPSPPPELSFPLPDTPKQSPPSPGESPSRQRISSSSSSGSSSSDSRSSSPEPASDTTERRPGPLTLLARKMASERACSGAGKRDREGVDLQRSHQEGVVSAITHTANAASVLSHPSSVISNQGVSVVRAAVMEASDGIKQDEGVLWEQEQERLKALEKEEEEREKALEKERAQALERKRLEAASKREKERALQREREEKERLEREQALERERALEQERLERERQE-KERVEKERQEKEQALERERLKQERLEKERQEREEALERERLERERLEKERQEREEALEKERLERERLEKERREKEAALERERLEKERLEKEKKEKEAALERERLEKERIEKEKREKEEALERERLEKERLEKEKREKEEAQERERLKKERLEKEKKEALEKERLEKERQEKEAVERERLEKERLEKEKREKEAALERERLEKERIEKEKREKEEALERERLEKERLEKEKREKEEALERERLEKERLEKERQEKEVLERERLEKERLEKERKEQEEALERERLEKEKLEKEKQEQALERERLEKERLEKERKEQEKALERERLEKEKLEKEKQEQALERERLEKERLEKERKEQETLEREKLEKLEKEKQEREQALERERLEKEHIEKEKREKEALERERLEKERLEKERNEREQAIERERQEKEEREREETLEKERKEQERLEKERALEKEREAALELKKQEQERLEKEKALEEERLQKEQALQHEREAERKKEEERKQALEKQKEEQERALKEEKREKLLKQKSVEEEKGKALKHEKEEEKESHLHPRKCGRDSGEFSHPVVHPGSPKSSPKKSDESEPGENPSISKDVQSSEPVPQQSPTLATPLSHQSSSKKSRFLRDAPVMAPLPSSVGSVLKRPRTFSDSPQPRAPSIPTDSKSKEPVQEDAAQAPQTSVLTSGPHDLERKTPEVAVKQSVPQENIQTSEDSEASKDTKHKTLTGVEDVKKSSTPEEEKKRGRAREKKVEKKERKSSSSSNTSSSDSDSGSSSSRSSSSSSSSSSSSSSEEEKSCSASGGRRSEEVKRDSSSQPTEKVCQTVAEKPPAPQRKKRVFTEKEEKDVNNEVIQNKKPCLDLQDGKETKEDIEEDADTNKDTTRSEVKEAVMSEPEKVSESGEESTMAKTFSARRISISSSKASPGVGSSEGEAETASSAGAGRKRRWGSSTAVTAKKP-SISITTDSLKSLIPD-IKPSVGQEAVLDLHPEEMHLSGEEEGG---ERS----DHDLKIRRTVTQIVPSETQENGQKESKRSDHEDEEETTEERDRISPEEKTEGSLQVSMETEPSSPGRDVDMKTVSPSDTRIRRSISQQKSGVSITIDDPVRTAKQPSPPRGKLSNIVHVCNLVRPFTLGQLKELLNRTGTVVEES-FWIDKIKSHCYVTYSSAEEAMATRTALHGVKWPQSNPKFLSVDFCTQDELD----FHRGLGP---AGEKPPEDARGAAAAGPGRPMPVPLLPE-----------------RDQWAEREREMERRERARAEREWDRDKVRDFSKPGEDREPGARRSRSRDRERRRKER---GKSKERKADKKEKGPEEPPAKLLDDLFRKTKAAPCIYWLPLTEEQAAQRAAARAERMREREKRIKEMEEEEGKKRE-EERRERMKPSGTAGG------EGERGRDRERERDRG----REREREGDKRK---EGYRRPGVNSASGSRRSRSRSDPPPRDRRR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VJ12-1", "uniprot_id": "Q9VJ12_DROME", "id": "Q9VJ12-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRRSERKKSSSPAPVPVAVARRS-----------------------------------------------------------------------------------------RRSRKVSENEKTEVETPVVAQNNEAECPKVPPASQEINEAR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASSEERAGSGASPVRRSRGSRTTPRKRTESKGG-----------------------------------------------------DKKVDTIPEEEPENGKDVEKDAVEEEK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVAPPAANESESEDRAKTE-------------------------------------------------DQQAQDDESCAEPAVVKDDDVE----------KEDLKPQQEVPTSTDDDTKQSEPEQEVKVPSPSSKDEEHLKTTSD--VLDIQTEEVDERDEEASAPAERRETKKRHKEQIKEQQPAEEEEHKENHKQIDENPEQIHDEPAD-----LSNDKHDPCLN-----------------------------------------------------------------------------------SSATNTTGAPVLQQQ---------RSVRKRKWLTNKKSSDRTPPVLAISTDSLKNIIADVVQPVPLSDVQLESSSEEEGLVTSDRDS----------------ERSASPAPPSEASKDRDNK------------------GNTANTCDTTAEASADNEGAGAAPPAAADTVSAQVSLSKATVSTAAP----------HIVRDPSPARNRASHVLYITNLVRPFTVLQLKGLLARTGKIVEEDGFWIDRIKSKCYVAYSTEDEAIETRHALHGVRWPVSNPKCLNVDFGSRTDMDRAILSTKDEAPRYGQENTRDNQQSGNAWSRLEPSDKKPARPVREWDVGKKEPSDHDKHSNDRRRDSKDRLDSRSRDAERAGQERKRSRDRE------------GRGRDRERERLDRNAHARSRSGSPASKTKKENEPPIRLLDDLFRKTKGTPCIYWLPLTPEAIAEKEAFRQKRIEEHKLRIKER-EERQKEREKDRDRQRETR-----------------RNRSNERRRS------RSRERERRRY--------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :* * . .:: : . . . . . : .: . .: ::..: : . :: . .. : . :: . . : :. . : . .. . .. : .. . . .. . : . : : . : . .* * : ..: . ***:* :.. : :.* ::*:*:***.:*.* ::* .:. :: .:: : .: *:.: *:: :: :.: . : * . ..*: : : ::* . : : **.*.: *::::: :******: *** ** ***.:*** ****:***:*:*:**: :**: ** *****:** **** * .*: : ::* :. . .:: : : :: *.* . :*.: :: *.*.*:*.* :* .:*:. . .* * :*** :******:***.:********* . .:: : .* .*:: * ** **. *:*: : ::* *. . ** *. * ** :: : ", "identical_positions": 122, "similar_positions": 197, "identity": "6.04%" }, { "cls_id": "homologset.agr.HGNC:17067", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K097-1", "uniprot_id": "LFG2_MOUSE", "id": "Q8K097-1", "name": "Protein lifeguard 2", "aln": "MTQGKLSVANKAPGTEGQQHQANGEKKDAPAVPSAPPSYEEATSGEGLKAGTFPQGPTAVPLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGP----------------------RRHFPWN--------LILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFD--FTSCQGVLFVLLMTLFFSGLLLAVLLPFQY---VPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O88407-1", "uniprot_id": "LFG2_RAT", "id": "O88407-1", "name": "Protein lifeguard 2", "aln": "MTQGKLSVANKAPGTEGQQ-QANGEKKDAPAVPSAPPSYEEATSGEGLKAGAFPQGPTAVPLHPSWAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGP----------------------RRHFPWN--------LILLTIFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTIFSFQTKFD--FTSCHGVLFVLLMTLFFSGLLLAILLPFQY---VPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BWQ8-1", "uniprot_id": "LFG2_HUMAN", "id": "Q9BWQ8-1", "name": "Protein lifeguard 2", "aln": "MTQGKLSVANKAPGTEGQQ-QVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGP----------------------RRHFPWN--------LILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFD--FTSCQGVLFVLLMTLFFSGLILAILLPFQY---VPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A140LGC1-1", "uniprot_id": "A0A140LGC1_DANRE", "id": "A0A140LGC1-1", "name": "Protein lifeguard 2", "aln": "MTQKKVAPADQA--VEGSK----------------PPSYEEANAG-----------------CPGYYYGDGG-------------------FTWDDASVRRIFIRKVYSILMLQLFSTVAVIALFTFHAPVRMYIQTHPILYSASNLLFLITYISLACCGDL----------------------RRQFPWN--------LILLTVFTLSMACMLGFISSFYNTKAVVLCIGITAVVCLCVTLFSFQSKID--ITSYQGLLFILCMVMFFCAIVMGFVVPFGY---VPWLHAVYSSIGAVVFTMFLAFDTQLLMGNKQYTLSPEEYVFATLSLYLDIVYLFTFLLQMFGQGRD--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1QZ65-1", "uniprot_id": "F1QZ65_DANRE", "id": "F1QZ65-1", "name": "", "aln": "MSLPAAPPSYAEATAGDKEQGSGSFTYASQPPPMPPPTMPMHPSWAYVHPGPSPGYSNAYAADMSSPFSDPSSSNSFDG----------LGSNWEDKNIRRMFIRKVFCILMVQLMVTFSVVSLFTFCEPVRKFVQYNRVFYLTSYMTFMGTYLMLVCSTNA----------------------RRRYPTN--------MILLAIFTLAMSYMAGMLASYHNTKVVMLSVGITALVCLAITLFCFQSRVD--FTTCHGLLFSLMMVLMITGLLLFFTAPFGY---IPWLHTAYAGFGALVFTLFLAFDMQLLIGNRRYSLNPEEHVFGAICLYMDVVYIFLFFLQLFGS-RE--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P48558-1", "uniprot_id": "BXI1_YEAST", "id": "P48558-1", "name": "Bax inhibitor 1", "aln": "-------------------------------MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVIS----------------------CEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFR----KVYPDEEVRCAMMLYLDIVNLFLSILRILANSNDDN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **. : . : :*: *::**: :* **: :.:. :. :: :: : : . : : : *. . :*: * : **::***: : .::: ::. *: .: **::* : ::: .:. :.: :.: .: : * : : : * : . :: *. :** :** :* :* **:: .: *:* : :: :*:*:: :* :*:::. .: ", "identical_positions": 38, "similar_positions": 96, "identity": "10.73%" }, { "cls_id": "homologset.agr.HGNC:17068", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ET54-1", "uniprot_id": "PALLD_MOUSE", "id": "Q9ET54-1", "name": "Palladin", "aln": "MSETSSHDSFYDSLSDVQEEGKSADFFPGLSAFLSQEEINKSLDLARRAIDSS------ETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAPVQPLTGDQAERITS----PGSKRKPGVSPLLASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSALMSASASQSPTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPTAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQAQKKTTSVSLTIGSSAPKTG----VTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVITSANNENCSYDSTG-EPNSDHFQHFPPPPP-------ILETGSYELASQKP--SEIQQVNSPNLGFSMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASR-ATAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVEP------EAMWGPSSPSPPPPPPPVFSPS---AAYPVPDVFPLPPPPPPLPSS--TSHCASPA-RFGPSQTPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKSS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGAD-SANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRVSCTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQPQTTKPKKVRPSASRYAALSDQGLDIKAAFQPEASPSHLTLNSGLVESEDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WX93-1", "uniprot_id": "PALLD_HUMAN", "id": "Q8WX93-1", "name": "Palladin", "aln": "MSGTSSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLDLARRAIADS------ETEDFDSEKEISQIFSTSPASLCEHPSHKETKLG-EHASRRPQDNRSTPVQPLAEKQTKSISS----PVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIF-KAAKPRNRSPNGESSSPDSGYLSPKNQPSALLSASASQSPME---DQGEMEREVKSPGARHCYQDNQD--LAVPHNRKSHPQPHSALHFPAAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTG----VTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMG-ESNNDHFQHFPPPPP-------ILETSSLELASKKP--SEIQQVNNPELGLSRAALQMQFNAAERETNGVHPSRGVNGLINGKANSNKSLPTPAVLLSPTKEPPPLLAKPKLDPLKLQQLQNQIRLEQEAGARQPPP---------APRSAPPSPPFPPPP-AFPELAACTPPASPEPMSALASRSAPAMQSSGSFNYARPKQFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPRQFGRAPVPPFAQPFGA-EPEAPWGSSSPSPPPPPPPVFSPT---AAFPVPDVFPLPPPPPPLPSPGQASHCSSPATRFGHSQTPAAFLSALLPSQPPPAAVNALGLPKGVTPAGFPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGAD-SATVFNIQEPEEETANQ-----------------EYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVESEDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P0C5E3-1", "uniprot_id": "PALLD_RAT", "id": "P0C5E3-1", "name": "Palladin", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEEICTLVIAESFPEDAGIFTCSARNDYGSVTSTAQLVVTSANTENCSYDSMG-EPNSDHFQHFPPPPP-------ILETGSYELASQKP--SEIQQVNTPNLGFNMAALQMQFNSAERETNGVHPSHGVNGLINGKAYGNKSPPTPAALLSPTKEPPPLLAKPKLG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPKKAS-RTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGAD-SANVFNIQEPEETAANQ-----------------EYKVSSCEQRLISEIEYRLERSPVEESGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFTCRVAGSPKPKIYWFKDGKQISPKSDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRVSCTGRLMVQAVNQRGRSPRSPPGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFIEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVY---------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0ACD6B6T9-1", "uniprot_id": "A0ACD6B6T9_DANRE", "id": "A0ACD6B6T9-1", "name": "Palladin", "aln": "MQDGSWNDTLPLSLLMNEACPSGGVSLEGDGGAVSGLSLDGEVYMDTMAELESGDGDFPELSAFLSQDEINLSLDLAREAMSDVDDPNDPKPPVPTEHLPLYSETKDHALPDSASHSVDATSGKVASSQSRQNHLCAASESPEKFVCQKSIAPVYKQDRPRLIHGGLELNERAASATEFCSRAATFIEELSSIFKGSARVDPQG-DEDSSSPDSGYLSPKSHRLAMQQAQPPSSSSS---SSEPQQEGVLQGQADVGSGELQGGGVSLDGP-------------VAPPRFTQKLKSQEVAEGSPIRLECRVTGNPLPLVRWFCEGRELHHCPDIQI-CRDGDLHTLVITEAFEDDTGRYTCVASNALGADNTSAEVYIEGASSSDSEGEGSVSKSRSGAMPQAQKKTSSVSLTIHTSSPKSPEAQPHRSTLVQPISTTPQRVQSPVSSLY--AGDALAKAPPSFTKVLQDAQPSEGQVVVLECRVRGSLPLRVQWFREGQEIQDSPDFRILQKKPRSAAEPEEICTLVIAEAFPEDGGLFCCTATNEYGSVNSTAQLTVTPVAEEMPTNGVSGDESVFEDNQSFPPPPPPLPPPPPPIEISLLEVPPKTPPSAEAFQINELDIWPSVTALPVQVSTDKKPEESRPNKPLQNGQFTKPLDESLSSPSSVKETAAPPPSPSAVRAPPLPTKPKPKLSN----EQADDVSNERN---------AVQLKQLQDQILLEQQQLPAPQEVSPPSPPLPPPPSFQELESSTMQTSTFNYARPKQFIAAQSP-TTSGAPIGYSSQSSSSSPLSPTTSHKPFSRVSLPPFHQQPLLSKSSSVESPSSPSFPPPPPPFLSSSNLSSPAGLPQEFPLPPPPPPPPVTSSPTRSDTSSPFTSTPHSPAGFLASVLPTTPPPPPMNALGLPKGNGTVALPRKTTPRTPRIISDSDIQGSKDAVIQDLERKLRFKEERLSNGQQRLTYEEKMARRLLGADNAATVFNTQQVEEEANTQEGSADSESVP-----QKEYKVSSFEQRLISEIEFRLERSPVEESDDDVQH-DEDAPGEVAPSFDQKLKHYKVFEGMPVTFSCKVMGDPKPKVYWFKDGKQISKRSEHYRISRDPDGTCSLHTTAASLDDDGNYTIMAGNPAGRVSCTGRMMVQAVNQRGRSQRSTPG--HIRRPRSRSRDSGDENENIQERHFRPHFLQAPGDLIVQEGKLCRMDCKVSGLPTPDLIWQLNGQTIRPDSFHKMLVRENGVHSLVIEPVTSRDAGVYTCIASNRAGQNSFNLELIVAAKEMHKAPSFIEKLQNTSVAEGHPVRLECRVSGVPFPQIFWKKENESFTHNTDRISMHQDNFGYLCMIIQPALKEDAGWYTVSAKNEAGIISSTARLDVHAQW-QQTHTPKLKKVRPSTSRYAALTERGLDVKAAFFPDSNP--LPPGT-LVESDDL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ***********:****.*:* *:* *:***..*****.:*.. * : * *. :. * ****** :* . *:..:.* :* *:* :: . :** :*..: :: :. . ** :. . * *:.. :.. .*. : * * :*:*:: **.** **.:***:****************: *.*** ******:********* :*.*** *: ** : .* ****** *********:*******:**.*:** : . . ** *: ******:********:*:* *.****:********** :*:** *.** **********::***********.*. **:*****:*********** **..* * *************** ****.************ ********************* ***:*:.:**** *************:**********:*****:********.***:***** **.* *:******.**:*:******** *** ***********:**.*:*:******.**:*::** * *****************:*.******: ", "identical_positions": 399, "similar_positions": 115, "identity": "27.57%" }, { "cls_id": "homologset.agr.HGNC:17069", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q80TY0-1", "uniprot_id": "FNBP1_MOUSE", "id": "Q80TY0-1", "name": "Formin-binding protein 1", "aln": "----------------------------------------------------------------MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKN------------SKEEEEYKYTACKAFLSTLNEMNDYAGQHEVISENMTSQITVDLMRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEK-----ARQQAQIRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSK-EGKPELRFGGKSRGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQPKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGVTPEDFS-NFPPEQRRKKLQQKVDDLNREIQKETDQRDAITKMKDVYLKNPQMGDPASLDQKLTEVTQNIEKLRLEAQKFEAWLAEVEGRLPAR-SEQARR---QSGLYDGQ-THQTVTNCAQDRESP---DGSYTEEQSQE--SEHKVLAPDFDDEFD----------------------------------DEEPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNED----EEGYVPTSYVEVYLDKNAKGS----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8R511-1", "uniprot_id": "FNBP1_RAT", "id": "Q8R511-1", "name": "Formin-binding protein 1", "aln": "----------------------------------------------------------------MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKN------------SKEEEEYKYTACKAFLSTLNELNDYAGQHEVISENMTSQITVDLVRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEK-----ARQQAQMRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSK-EGKPELKFGGKSRGKLWPFIKKNKLMTLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGVTPEDFS-NFPPEQRRKKLQQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVTQNIEKLRLEAHKFEAWLAEVEGRLPAR-SEQARR---QSGLYDGQ-THQTVTNCAQDRESP---DGSYTEEQSQE--SEHKVLATDFDDEFD----------------------------------DEEPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNED----EEGYVPTSYVEVYLDKNAKGS----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96RU3-1", "uniprot_id": "FNBP1_HUMAN", "id": "Q96RU3-1", "name": "Formin-binding protein 1", "aln": "----------------------------------------------------------------MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKN------------SKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEK-----ARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFS-NLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPAR-SEQARR---QSGLYDSQ-NPPTVNNCAQDRESP---DGSYTEEQSQE--SEMKVLATDFDDEFD----------------------------------DEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNED----EEGYVPTSYVEVCLDKNAKDS----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B4Q2-1", "uniprot_id": "A0A8M3B4Q2_DANRE", "id": "A0A8M3B4Q2-1", "name": "", "aln": "-----------------------------------------------MHSNRGLSRRSCLETMSCSWGTELWDQFDNLEKHTQWGIEFLERYTKFVKERSEIELSYAKQIRNLSKKYQLKKN------------SKEEEEYKYTTCRAFLMTLNELNDYAGQHEVIAENLSSQIIAELSRYTQELKAERKSHFHDGRRAQQHIENSWKQLESSKRRFERDCKEADRAQHYFDKMDADINVTKADVEKRCSLKAKQQAQMRHQIAEDSKNEYLTYLQKFNKDQHEHYYTLIPHIFQRIQEMEERRVGRVRESMRVYTEVERKVLPIVSKCLDGMTKAAESVEPKMDSKQVVESYKSGFEPPGDVDFEDYSVSMKRAVSESSFLNARGESRR------RSRSKLWPLLKRNKLMSLLASPRQPPPPPPTSPSPDGLQNGPQSPQQPKEPLSQRLNDFMGTKHKMHCLRSLKRGLSLKLGTGQEDYS-HLPPEQRRKKLQAKLNDVNKDIQKEMDQRDALTKMKDVYIKNPHLGDPDSIDPRLEEITQSLEKLQFEAHKYEGWLTEVERKLLEKGSESQRR---QSSHFDSQGNTPLTNNYGQNRESP---DGSYTEDPSTENTMQFKSRSTEFDDEFD----------------------------------EEEPLPTIGTCKALYPFEGQNEGTISMAEGEMLYVIEEDKGDGWTRVRRNED----EEGYVPTSYIKLFLDTNAKGAMTYI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A8JNK4-1", "uniprot_id": "A8JNK4_DROME", "id": "A8JNK4-1", "name": "", "aln": "MLKKKLAQITKKKTVADLEAECVHSAIAFTCVRVCAKLLASGSSRSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALDKFANFLRDRVAIETEYAGKLRRLVKNYQPKK--------------KEEEDNEFTSVQAFRNLLKEVGDLAGQREVVSESLQLQIIAGVTLLSKTLREERKKCLSDGATLQQNLTTQLSSLDRAKRNYEKAYRDSEKAVDSYKRADMDLNLSRAEVER-----YKNVMTSKIQQSDDAKNEYANQLQKTNNLQQQHYSMLLPSVLNRLQELDEKRTRGFREFIVGAADVESSVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNST--------------------------------------------SNHLTIRGTMSANKLKKRVG-IFNIFGSNKN------------SLTADGQKEDFS-DLPPNQRRKKLQAKIAELTQNIAQETKARDGLMKMKIVYEANSSLGNPMTVEGQLNESEHKLEKLKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSRSDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVGKCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIEITLYA---------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38822-1", "uniprot_id": "BZZ1_YEAST", "id": "P38822-1", "name": "Protein BZZ1", "aln": "------------------------------------------------------------MSADLSIGNEIKDSFKETHKWVQNNLKWLKDIEQFYRERAKLEKDYSERLSRLSAEYFNKKSSTSVPISVGDTPTTTPGSIEAAGVVAWNEILSQTDMISKDHDQLSTDFENHVANQLSGLFTKLDMTLSKINGFNNDMVNKKDNIYHELEKAKKDYDEACSTMEMARNRYTKASNDRNKKKLDEKE--------------MEMNKCKNEYLIKINQANRTKDKYYFQDVPEVLDLLQDVNEAKTLFLNDLWLKAASVENDLGANVSKRLQAANSVVKQNKPSLNTAIFIKHNLKNWKEPQDFVYKPSPVWHDDEKFAVPSSLEVEDLR----------------IKLAKAENDYNSLQDKTQNELSKLSTLNKIKHEMKTNEDNINATKFYDTLKEYLNVVSPFTS-HETLKLQAEVQIESIQNNVPEEYDLSTDNIDLSKTKKKSGIFSKFKHNILNVDSKPSSGGSTGNGNGGPLHITSLFNTSRRTRLGSAPNNAGEDSDNNSIRTTSTNNTKKT--TQNSSDDGKNKVLYAYVQKDDDEITITPGDKISLVARDTGSGWTKINNDTTGETG------LVPTTYIRISSAATVKANDRGPAPEVPPPRRSTLPVRTMEAIYAYEAQGDDEISIDPGDIITVIRGDDGSGWTYGECDGL-----KGLFPTSYCK--------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *.*: *. .: .: .:. *. :* ::* :* .*: :: .* :* ** . . : : *: *.: . : ::: :: .: :: : * .. . :: . .*: :*: ::. : * . : : . * * .: : :. :..* :* ::: *. : ::* :* ::: :*:::* : . : :.*: .: . :.: ::. .. :. . . :: .:: ..: * *. :: . * . ..:: : : : .* *. . ..* : .. : .: . .:. . :. : ::. . *: :: . :. .: :. :. . . : . : .. . . .: :. *. : : : . .. .: . .*:*.:*...:. *.: *: : **. *.*.*** . : :* .**** : ", "identical_positions": 54, "similar_positions": 202, "identity": "7.19%" }, { "cls_id": "homologset.agr.HGNC:1707", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P05541-1", "uniprot_id": "CD8B_RAT", "id": "P05541-1", "name": "T-cell surface glycoprotein CD8 beta chain", "aln": "MQPWLWLVFSVKLSALWGSSALLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERV--KKNMTL-SFNSTLPFLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVVDVLPTTA-PTKKTTLK---KKQCPTPHPKTQKGLTCGLITLSLLVACILVLLVSLSVAIHFHCMRRRARIHFMKQFHK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P10300-1", "uniprot_id": "CD8B_MOUSE", "id": "P10300-1", "name": "T-cell surface glycoprotein CD8 beta chain", "aln": "MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDP-KDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTA-PTKKTTLKMKKKKQCPFPHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P10966-1", "uniprot_id": "CD8B_HUMAN", "id": "P10966-1", "name": "T-cell surface glycoprotein CD8 beta chain", "aln": "MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVF--RDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLK---KRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:* ***::: :*:.* ..*.* ***: : ****: . :***.* . *****: * . .:.:.**** *:** :** * :: : :: :*.: .******.:*** **** :.**.**:*:***.***** ****:*** *: * *:*:**** *. **.***. :*:**. *.**::: * *****::*****:*", "identical_positions": 102, "similar_positions": 60, "identity": "47.44%" }, { "cls_id": "homologset.agr.HGNC:17070", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LRV2-1", "uniprot_id": "A0ABK0LRV2_RAT", "id": "A0ABK0LRV2-1", "name": "Switch-associated protein 70", "aln": "MGGLKDELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDNKDGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDIMLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRRKLLAEQEELERQMKELQAANENKQQELESVRKKLEEAASRAADEEKKRLQTQVELQTRFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLAQQQAIQTTEAEKQELEQQRVLKEQALQEAMAQLEQLELERKQALEQYEGVKRKLEMATNTTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTQAELEEREKSWKEKKTTD----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6A028-1", "uniprot_id": "SWP70_MOUSE", "id": "Q6A028-1", "name": "Switch-associated protein 70", "aln": "MRGLKDELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDNKDGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIYSTIHLLKLGSPPPHKEARQRRKELRRKLLAEQEELERQMKELQAANENKQQELESVRKKLEEAASRAADEEKKRLQTQVELQTRFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEQQRVMKEQALQEAMAQLEQLELERKQALEQYEGVKKKLEMATHMTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTQAELEEREKSWKEKKTTE----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UH65-1", "uniprot_id": "SWP70_HUMAN", "id": "Q9UH65-1", "name": "Switch-associated protein 70", "aln": "MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LYE0-1", "uniprot_id": "Q1LYE0_DANRE", "id": "Q1LYE0-1", "name": "Switch-associated protein 70", "aln": "MG-LRDELLKAIWHAFTALDVDKSGKVSKSQLKVLSHNLCTVMKIPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILDKVQDNFDRIDFNRMCWTLCARKNLNRNHLLISDDDAFKIWCIFNFLSEDKYPLVMVSEEIEYFLRKLTEAMGGSWIEEKFEQYKLQLSSKHQCLKVWELIELVGMGHFSKGMDRQTLSMGITEVFHELILDVLKQGYMMKKGHKRKNWTERWFLLKPSLISYYVSEDLTEKKGDILLDGNCCVESLPDKEGKKCLFYVKCSDKSFEISASDKKKKQEWIQAIQTCITLLKVGRPAPHHEARQKRRELRQKQQAEQEELELRMRELQMANENKQRELEAMRKKLEEAAANAADEERRRLQTQNELQDLYRLEMEKEKMVRQQMEEQVAQKSNELEQYLQRVRELENMYHSLEEALEEERQARQDEETVRKLQARLLEEEVSKRAELEEIHLYQQQTISQTQAEKQELERERLAKESALESAMQQLHQLEADRQGALEQYQEVMKKLSDAANNTKSWKDKVAQHEGLIRLIQPGPKYPQKITNWGPAAFTDAELNLREKDWQEKKNRPATPQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB13A3H9-1", "uniprot_id": "A0AB13A3H9_DANRE", "id": "A0AB13A3H9-1", "name": "Switch-associated protein 70", "aln": "-MISKEEILKPIWYAFTALDLDRNGKVSKSQLKVLSHNLCTILKIPHNTSALEEHFKDDDEGPVSTQGYMPYLNTFILSKIQPNFDFVELNKMCWTLSAPKHINTMNLLMSEKDAFRVWCIFNFLSEDKYPLTIVTEELEYFLRKLLTAMGCSWNEGRFEDYKMHLNAKKHHLNAWELIELIDMGNFTKGINPQTVSMGINEVFQELVMDVIKQGYMMKKGHKRKNWTERWFELHLNYMSYYVSEDLVEQKGCIPLDRNCCVESMPDKDGKKNLFIIRCVEKSFEISASDKKAKQEWIQAIQDCIVRIRQGLSSAHRESRQKRRELRNRIKAEQEILENRMKQLQLANESKQAQLEALSKDLNKATARGDLEEQRRLQAQKELLEQYKRDLEQEKMARMQMEEQVIEKSNEVEQYWQRMQELEEMYLQLKQALQDEKQAKEDEEILRKLQARLLQEEENKRLELEQIHLQQQRVLSQSQKEKEELAKEREEKERALQAAQEQLESLKRQREGAEEEYMAVTKKLERASKKTKTWKHKVSKHEGLLKLVQPGGKTPSKMTNWGQAAFTESELNELEKMWQVNKNRSEEE-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::*:**.**:****** *:.*****************::*:**:. ******:********.******** ***.*:* *** :::*:*****.. *::. **:::.***::* ************ :*.**:**:*:** *** .* : :**.**:::. .:. *..******:. *:*:**:: **:**.*.***:**::**:**********:********* *: . :******** ::** * ** ******:***:*** ** ::* :*:********* ******** * :: * ...*:*:**:*:***.: **** ** :*::** ***.** :**:: *.*::*::.. **::***:* ** : ::*:**: * ****** :**.*:*** **::***:** .*::**::*:**::*** :********:** .** ***: ** **:.:. :: **:** .:* ** **: * **..*: :*: * *:* * :**. *:: **:**.**::****::*::** * * :**** ****::**: ** *: :*. ", "identical_positions": 330, "similar_positions": 160, "identity": "56.03%" }, { "cls_id": "homologset.agr.HGNC:17071", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LS62-1", "uniprot_id": "F1LS62_RAT", "id": "F1LS62-1", "name": "[histone H3]-trimethyl-L-lysine(9) demethylase", "aln": "--MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR-QCYDDIDNL---LIPAPIQQMVT----GQSGLFTQYNIQ-KKPMTVKEFRQLANS-----------------------------------------------SKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQ-----------------------GKDIYTIDHTKPTPESTPEVKTWLQRRKKLRKAPKSLQGNKSLSKRPKAEEDEEFAEFI-GEEVSSPAVCPRHLKVTEKPEK-FKLANIGASSEKEASDTRIQVDQSLTNDTKLSGKSCINSSVIDEIQPENDTANAVTS-PSTLKKASDLIPFSHGHITGKESRLLKILQLESPKIPSSLAESNRVLTEGEENDEEGHASNLEPGEVPDALSEERNGLNVPKIIEGQPK-----TTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDNSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVEYSPPNAFLEEDGTSLLISCSKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRQRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNVKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQIFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCD7-1", "uniprot_id": "KDM4C_MOUSE", "id": "Q8VCD7-1", "name": "Lysine-specific demethylase 4C", "aln": "--MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR-QCYDDIDNL---LIPAPIQQMVT----GQSGLFTQYNIQ-KKAMTVKEFRQLANS-----------------------------------------------SKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQ-----------------------GKDIYTIDHTKPTPESTPEVKTWLQRKKKLRKPPKSLQGNKPLCKRPKPEEDEEFAEFS-GEEGANPAMGPRHLKVTEKPEKALKLGKLEESSAKEALDTRIQVDQSLLNDTKLSGKGCISSSVTAEIPPEDNRASAVIS-PSQLKEGADCIPLSHGHQAGKESHLLKILKLESPKIPSPLPESNKVLTEGEENDEEGHGSNLEPGEIPEALSEERNGLNIPKIIEGQPK-----TTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDSSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVDYSPPNAFLEEDGTSLLISCAKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRHRVKKVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNAKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQTFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3R0-1", "uniprot_id": "KDM4C_HUMAN", "id": "Q9H3R0-1", "name": "Lysine-specific demethylase 4C", "aln": "--MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR-QCYDDIDNL---LIPAPIQQMVT----GQSGLFTQYNIQ-KKAMTVKEFRQLANS-----------------------------------------------GKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQ-----------------------GKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENK-----TSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V333-1", "uniprot_id": "KDM4A_DROME", "id": "Q9V333-1", "name": "Probable lysine-specific demethylase 4A", "aln": "MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGY-DIDNIN-MTIPAPICQVVT----GAHGVYQQINIQQRRQMTLRQFMEKANS-----------------------------------------------ELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLK-----------------------GQDMG--CHPEEP-GKICAAAP-------------------------------------------------PTLNEYE-----------------------KQEN------LRA--------------AKSEEESPQKRG-----------------------------CSLAG---------------NGCERNAES------------AEDVDD---------KASVS-----SYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFN-TEAVVRVKRLWN------ELPCPDRGANLLTNGVVKNTKRMRFQTKVLTLDDED---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9V6L0-1", "uniprot_id": "KDM4B_DROME", "id": "Q9V6L0-1", "name": "Probable lysine-specific demethylase 4B", "aln": "---------MKMSEVPRIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALN-VTIPAPICQVVT----GKQGYYQQINIQ-KKPLTVKQFSELAST-----------------------------------------------ERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGSITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME-----------------------GRDVG--RHPEDPPNAVLSAAPLPPHL-------DVLLCDKKMKKQCNPTKAKSFKERN------------PDLDLDE-----------------------IQQNPNVPDDVKAMLKESVLTLDTGDLATDEADFPNEDA-----------------------------MSLQSPANLKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWL----ASKRKTN-----SRNNRGRSPRTKDDRSISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTSPAVSSAATAVKTPTSAVVAGTTSIATTTTPPADGGGGESSSLGSHCTTASP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03833-1", "uniprot_id": "GIS1_YEAST", "id": "Q03833-1", "name": "Transcriptional activator/repressor GIS1", "aln": "------MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENG-IVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAES----------LDSR---ISQG-DFNDKTLKENCRVD-----------SQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSIN------------SSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTS----AAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRN---NVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKP-KILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMS---DHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHS------------CPRCGKRFKRRDHVLQHLNKKIPCTQ--------------EMENTKLAES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P39956-1", "uniprot_id": "RPH1_YEAST", "id": "P39956-1", "name": "DNA damage-responsive transcriptional repressor RPH1", "aln": "----MTKLIAPSEIVGGVPVFKPTYEQFEDFYAYCKAINKYGMKSG-VVKVIPPKEWKDKLDLPYSAETLQKIKIKSPIQQHIS----GNKGLFMVQNVEKNKTYNIIQWKDLSKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSFNIDDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLPNILDHMETKV----PGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNCPEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFALEEWLPIGKKAGKCHCISDSVEIDVKKLAKSWRDNNK-ESKG-----------------------TPPLNQLPNPAMPLLHRPTLKEMESSSLRSTSPD-VGHFSNF-KSKSSGVSSPLLSRMKDYSNIVEPTLEDPTLKLKR---------------ISSFQEQPLN---KLLKRETS----------------------------------------------------------QTAMLT------------DHEDNIVAMSLTSMANSAASSPRLPLSRLNS-----------------------------SNELSNAQPLLDMTNNTLAFPRPNGPSGLNPL-LYISNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNISRESSRSPIA-LNYEARQQHSQQHSFSTPSTVSNLS--TSVLGPLSDTNDIKTPHPERPNHKTANRILKKESPVETSKSNLILSKVASTRQED-SFTSRNDDLDKEQGSSPLN----------SKFAPEEIVLS---GKNKIYICKECQRKFSSGHHLTRHKKSVHSGEKPHS------------CPKCGKRFKRRDHVLQHLNKKIPCISNETTVDAPIMNPTVQPQDGKAAINQQSTPLN----------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : .*:*: :* :* : : . * . . :.*: ** ** . : : : :** * . * : * .: .: :: : :. . ** :**.: : *:*..* .*: . **: .* :: . * * * *.** :: : ****:*** ** ** :* :: :. . . . : * ::**: : **..*:: .: ..:.: *::**:*: ::***:*:* .** :* . * . * * .. : . : . .. : . . . . . : : . . . . : ", "identical_positions": 65, "similar_positions": 109, "identity": "5.69%" }, { "cls_id": "homologset.agr.HGNC:17072", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q811U3-1", "uniprot_id": "RB6I2_RAT", "id": "Q811U3-1", "name": "ELKS/Rab6-interacting/CAST family member 1", "aln": "MYGSARSVGKVEP------SSQS-PGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVG---AETPKSTMTLGRSGGRLPYGVRMTAMGSSP-----NIASS-GVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIM-DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES-----------------------------------------------------------------------------------------------LLEQKEKENNMLREEMHRRFEN----------------------------------------------------------------------APDSAKTKALQTVIEMKDSKISSMERG----------------------------------------------LRDLEEEIQMLKSNGALSTEEREE---------------------------------------------EMKQMEVYRSHSKFMKN-------------------------------------------------------------------------------------------------KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLKEKVSLLQGDLS-----------EKEASLLDLKEHASSLASSGLKKD-----------------SRLKTLEIALEQKKEECLKMES------------------QLKKAHEATLEARASPEMSDRIQQLEREIARYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK---SAQMLEEARRREDSLSDS---SQQLQ--------------------------------------------VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR------KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK-TQEEVAALKREKD-------RLVQQLKQQTQNRMKLMADN-----------------YEDDHFRSSRSNQTNHKPSPD---------------------------------------------QDEEEGIWA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99MI1-1", "uniprot_id": "RB6I2_MOUSE", "id": "Q99MI1-1", "name": "ELKS/Rab6-interacting/CAST family member 1", "aln": "MYGSARSVGKVEP------SSQS-PGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVG---AETPKSTMTLGRSGGRLPYGVRMTAMGSSP-----NIASS-GVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIM-DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES-----------------------------------------------------------------------------------------------LLEQKEKENNMLREEMHRRFEN----------------------------------------------------------------------APDSAKTKALQTVIEMKDSKISSMERG----------------------------------------------LRDLEEEIQMLKSNGALSSEEREE---------------------------------------------EMKQMEVYRSHSKFMKNKVEQLKEELSSKDA---------------------------------------------------------------------QGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLS-----------EKEASLLDIKEHASSLASSGLKKD-----------------SRLKTLEIALEQKKEECLKMES------------------QLKKAHEATLEARASPEMSDRIQQLEREISRYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK---SAQMLEEARRREDSLSDS---SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR------KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK-TQEEVAALKREKD-------RLVQQLKQQTQNRMKLMADN-----------------YEDDHFRSSRSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTALCHDRDPLILRGLTPPASYNADGEQAAWENELQQMTQEQLQNELEKVEGDNAELQEFANTILQQIADHCPDILEQVVNALEESS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IUD2-1", "uniprot_id": "RB6I2_HUMAN", "id": "Q8IUD2-1", "name": "ELKS/Rab6-interacting/CAST family member 1", "aln": "MYGSARSVGKVEP------SSQS-PGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVG---SETPKSTMTLGRSGGRLPYGVRMTAMGSSP-----NIASS-GVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIM-DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES-----------------------------------------------------------------------------------------------LLEQKEKENSMLREEMHRRFEN----------------------------------------------------------------------APDSAKTKALQTVIEMKDSKISSMERG----------------------------------------------LRDLEEEIQMLKSNGALSTEEREE---------------------------------------------EMKQMEVYRSHSKFMKNKVEQLKEELSSKEA---------------------------------------------------------------------QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS-----------EKEASLLDLKEHASSLASSGLKKD-----------------SRLKTLEIALEQKKEECLKMES------------------QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE----RQVKDQNKKVANLKHKEQVEKKK---SAQMLEEARRREDNLNDS---SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR------KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK-TQEEVAALKREKD-------RLVQQLKQQTQNRMKLMADN-----------------YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IEU4-1", "uniprot_id": "A0A0R4IEU4_DANRE", "id": "A0A0R4IEU4-1", "name": "", "aln": "MYGSSRSVSKMDSNHSAGRNNQSNSGRSPRLPRSPRMGHRRTNSMGGSGG-GPGGSGGKTLSMENIQSLNAAYATSGPMYMSDNEVAIGTSSDHPKTAVATGRFGGSIPYGVRGTVTGSTP-----DMAMVPAVSTDSMGFGG----EIHAASTVPHSLRQARDNTIM-ELQAQLKEVLRENELLRKEIEVKESKLSSSMSSIKSFWSPELKKERALRKDEASKISVWKEQYRAVQDETQHLQTTVQALQAELRIQRDLNQLLQP-----PGEPLACEPSEE--------QERQARELFLLRRTLEEMELRMEAQRQTLVARDDSVKKLLEMLHSKGPSAKASEEDHERTRRLADAEMHAHHLEN-----------------------------------------------------------------------------------------------LLEQRDKELVALREELHRRLEG----------------------------------------------------------------------TPETTKTKALQTVIEMKDSQIGSLERG----------------------------------------------LRELEDQVMMLRSSSMLSCEERQE---------------------------------------------EAKQMEVYRNHTKFMKN-------------------------------------------------------------------------------------------------KMDQVKQDLSRKDTQLLGLQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETTLNKKSKQIQEMSEEKSTLNGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLRERVKSLQTDTSNTDTALTTLEDSLAEKERIIERLKEQRDREEREKAEELDTSKKELKELKEKVSLLQGDLS-----------DRETSLLDLKEHASSLASSGLKKD-----------------SKLKSLEIALEQRREECSKLEN------------------QLKKAHSAAVNAQANAEISERISSLEADVSRHREDSAKAQAEVDRLLDILRQMENEKNDKDRKISELESVASRQMKEQSKKSG--KHKEPPGKGRNVNDGPQQESLRQKAERIEEL---EEALR------------------ESVQITAEREMVLAQEEAARNHQEKQMEELLGAMEKVKLELESMKAKMSSTQQSLAEKEAHLTTLRAERR------RHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKKTQEEVAQLRREKD-------RLVQQLKQQTQNRMKLMADN-----------------YDDGYLKTP-PDQTNHKPPKS---------------------------------------------PDQIRSGRRVTVRRSSTLAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K7K9-1", "uniprot_id": "ERC_DROME", "id": "A0A0B4K7K9-1", "name": "Protein bruchpilot", "aln": "--MSRDDYNPVTS------SGVRSPGRVRRLQELPTVDRSPSRDYGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAHA---MDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSPSAMGGYNTGMGPTSDRAYLGDLQHQNTDLQRELGNLKRELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEELRLRMRQ----------------PNLEMQQQMEAIYAENDHLQREISILRETIKDLECRVETQKQTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLPDIIGQYYGPGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAGLPSATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTPLGGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPAISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHVHQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPHSHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEHKRQLDEFRLEIQRRDQEILAMAAKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERAREEAAALQEKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKIKEEMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKACTENRRLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLSLDTDRIREKLEKTQVQLGRIQKERDQFSDELETLKERSESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALYASQKLIDEKDTSNKEFEKMLEKYDRAQNEIYRLQSRCDTAEADRARLEVEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQLSRAKECEDNARSELEHSRDRFDKLQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKASASVEAAKEEAAHYAVELEKMRDRYEKSQVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETIRGKSQYESESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHIEREKARDKHEKLLKEVDRLRLQQSSVSPGDPVRASTSSSSALSAGERQEIDRLRDRLEKALQSRDATELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLEKAEAEREALRQANRSGGAGAAPHPQLEKHVQKLESDVKQLAMEREQLVLQLEKSQEILMNFQKELQNAEAELQKTREENRKLRNGHQVPPVAAPPAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQQAQAAAAAGASREEIEQWRKVIEQEKSRADMADKAAQEMHKRIQLMDQHIKDQHAQMQKMQQQMQQQQQAAQQAVQQAAQQQQSAAGAGGADPKELEKVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQTAQQQVQQLQQQVQQLQQQMQQLQQAASAGAGATDVQRQQLEQQQKQLEEVRKQIDNQAKATEGERKIIDEQRKQIDAKRKDIEEKEKKMAEFDVQLRKRKEQMDQLEKSLQTQGGGAAAAGELNKKLMDTQRQLEACVKELQNTKEEHKKAATETERLLQLVQMSQEEQNAKEKTIMDLQQALKIAQAKVKQAQTQQQQQQDAGPAGFLKSFF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . : . .. .** ** . * :.: :.. *.. * . .. .*:: * .* . : *:: ** : * * : : .: : :* . .: : *.: : :** * .:: ** *::::*:.:.**.*** ***:**************:*::* :: ::* : :. *.*: :: *: ***:: :: ::: :*: :**.*::::* *:*:*:*** ***:*:*******::** . : .: .:: : :*: :*: :: * : ..: * :* *: :. *:: :.* * : :* .: * *:* . : *. :* ::: : : *: * : :* ::.:.: ::.*:* ::*.: :*::** :*..* ::** ****** ***:: :***:*: :* *****: ::**:: : :*:. .*: :*** :*:*:**:.***:*****:: *::*::*:. : *:.::*:. :.:: ***:**:::.:**: : :*::**** *:** ** * :::: : : *: :.::. ::* :.:: *.*..* : : .:: **: *: :.: : :. :..::. . : * .: : :: :.:: :*: *. * : *.: :.* . *: : : :: .* . .: . . *. .: : . : *: ::: * ::: * *::. . . ::.* :.:.:* :: ** . *:* * * *: * :::* : **: ..: : :: *: *:* * ::*.: **: :: :: : . : :: . . * .. ", "identical_positions": 211, "similar_positions": 345, "identity": "9.32%" }, { "cls_id": "homologset.agr.HGNC:17073", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AL79-1", "uniprot_id": "A0A8I6AL79_RAT", "id": "A0A8I6AL79-1", "name": "Rho GTPase-activating protein 26", "aln": "--------MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQK----SGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETD--ICAEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVP--DVPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHAVPS------------------------TEKQEQRNSIINSSLESVSSSANSILNS----SS------SLQPNMNFSD---------------------------------PSLDVVKPT---------------------RPNSLPPNPSPTSPLSPSWPMFSAPSSP------------------------------------------------------MPTSSTSSD------------------------------------------SSPIR---------------------------------------------PEEVVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZQ82-1", "uniprot_id": "RHG26_MOUSE", "id": "Q6ZQ82-1", "name": "Rho GTPase-activating protein 26", "aln": "--------MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFAAVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQK----SGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNRDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETD--ICAEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVP--DVPLTNAQLHLSRKKSSDSKPPSCSKRPLTLFHAVPS------------------------TEKQEQRNSIINSSLESVSSSANSILNS----SS------SLQPNLNSSD---------------------------------SNLDVVKPS---------------------RPSSLPPNPSPTSPLSPSWPMFSAPSSP------------------------------------------------------MPTSSTSSD------------------------------------------SSPIRSVAGFVWFSVAAVVLSLAWSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVREDSSTPFRKAKALYACQAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UNA1-1", "uniprot_id": "RHG26_HUMAN", "id": "Q9UNA1-1", "name": "Rho GTPase-activating protein 26", "aln": "--------MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQK----SGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETD--ICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVP--DMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQS------------------------TEKQEQRNSIINSSLESVSSNPNSILNS----SS------SLQPNMNSSD---------------------------------PDLAVVKPT---------------------RPNSLPPNPSPTSPLSPSWPMFSAPSSP------------------------------------------------------MPTSSTSSD------------------------------------------SSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "X2JDY8-1", "uniprot_id": "RHGF_DROME", "id": "X2JDY8-1", "name": "Rho GTPase-activating protein Graf", "aln": "MGGGKNVRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEK--RTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKLTLFSCQRRAS-EFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** .***.:* :***.***.*: ** ***:*.: **.:**: *.*:** * **: :::* **:*:*:*** *:**** *..**:.*.::: *:**** :*: *.: :* .**.***:***..:* ***:**:***:* *:.**:*:** *. :****:.:.: .:.: : **.**:::****** ***** ****:.* :.*** .:* *:*. *: :* .:*:**:.** :*.:* .* .* *: . *. . :* .***:: ** . * ::*.*:***::::.:::**: *:* : :. :**.: * ** ** : .:*******: ::***: *:*****:*:* *:.**** **.* : . : . : :**. ** :**:**:.:* **::::*:** **.:::.***:: :: * :.:. .* * :*::**** *** * *** **:: .**:*** *. : **.*:*.**::**: * ***:::: **::*:.::::* *:* *************:**:****:****:****:***:*:*:**:. * *: *.:* * .* *.**: *. : ::. : ..* : :. :.***:.:... * *.* ** **.* :: : .. :: .. :*. * ....*.: ..* ::: .**. ****::**: ** : ::.* ** :.::**** .* :.**** .. :: **: *:*****:****************.* ", "identical_positions": 339, "similar_positions": 270, "identity": "32.98%" }, { "cls_id": "homologset.agr.HGNC:17074", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZUM2-1", "uniprot_id": "SARM1_RAT", "id": "D3ZUM2-1", "name": "NAD(+) hydrolase SARM1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLTLLFSAYKLCRFFIMSGPRPGADRLTVPGPDRSGGTSPWWAAGGRGSREVSPGVGT---------------------------------EVQGALERSLPELQQALSEL---KQASAAQAVGAG-------LAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLS---KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSTLAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFRDQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMAARNFVLVLSAGALDKCMQDHECKDWVHKEIVTALSCSKNIVPIIDG-FEWPEPQALPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQG------------------------------------------------------------------------------RPSQDSSAGSDTSLEGATSMGLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6PDS3-1", "uniprot_id": "SARM1_MOUSE", "id": "Q6PDS3-1", "name": "NAD(+) hydrolase SARM1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLTLLFSAYKLCRFFTMSGPRPGADRLTVPGPDRSGGASPWWAAGGRGSREVSPGVGT---------------------------------EVQGALERSLPELQQALSEL---KQASAARAVGAG-------LAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLA---KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSALAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFREQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKLSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVIAARNFVLVLSAGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDG-FEWPEPQALPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQG------------------------------------------------------------------------------RPSQDSSAGSDTSLEGATPMGLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6SZW1-1", "uniprot_id": "SARM1_HUMAN", "id": "Q6SZW1-1", "name": "NAD(+) hydrolase SARM1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGT---------------------------------EVQDALERALPELQQALSAL---KQAGGARAVGAG-------LAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLA---KEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDG-FEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQG------------------------------------------------------------------------------RSSRDSSAGSDTSLEGAAPMGPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QWA8-1", "uniprot_id": "SARM1_DANRE", "id": "F1QWA8-1", "name": "NAD(+) hydrolase SARM1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFLSLVVYLSKICRYLSMFS----SDRLTVPEYVSSRLHNRRTAPD---PRAVSPGIST---------------------------------DVQAVLDGSLPALRSAIRTLRSSKDTGDLEETRRA-------IAETFQLVEEAWVLPTVGRRVAEEICNRIRLDGGLELLLQLMQTPAVEITYESAKLLEQILVSENRDYVARMGLGVILNLT---REQEDAQLARSVSGILEHMFKHTEETSAQLITNGALDTILYWCRGTDPTVLRHCAVALSNCAMYGGHRCQRLMIEKQAAEWLFPLAFSKEDELIRFHACLAVAVLAANREMEKEVVKSGTLELVEPFIASLDPDEFARNMLDSADSMQGRTAADLQHLLPLLDGTRLEGKCIAAFYLCVETSIKSRQRNTKIFQEIGAVQSLKRIVMYSSNATVCSLAKRALKMMSEEVPRRILSSVPNWKSGEVQTWLQQIGFSAFSERFQELQVDGDLLLNITEQDLIQDLGMTSGLTRKRFLRDLRVLKTYANYSTCDPNNLADWLADADPRFRQYTYGLVQSGVDRNNIVHITDQQLLTDCHVENGIHRAKILSAARRPSKPCL--TDSQPKG--PDVFISYRRTTGSQLASLLKVHLQLRGFSVFIDVEKLEAGRFEEKLITSVQRARNFILVLSANALDKCMGDVAMKDWVHKEIVTALNGKKNIVPVTDN-FVWPDPTSLPEDMSTILKFNGIKWSHEYQEATIEKILRFLEG------------------------------------------------------------------------------CPSQEKPDGAKTDKKEPQKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6IDD9-1", "uniprot_id": "SARM1_DROME", "id": "Q6IDD9-1", "name": "NAD(+) hydrolase sarm1", "aln": "MKAAEIKRDLTNIQKSMSEINDLAKERITGGPGSISTTSASAITAPSTMSQTTTSRLAPKLTSAHPSIDDLRGLSRQDKITQLQKKIRASFENLVDHDDSNVIVTLPDDDDCPHNHFGSGLNLTHPTAAQLSASGLSGSSKTIDTIKFQEKSMKTESKTKVVTDGFSSEQATSNSAEMKRLQAGDIDYQESKGASAMRNRLEVDGVKTEENAAVIKEALSLRTGDITQQASNNVAASSITVQSENFSADKKAISQSQQSQTMTSNGIISQEKHVSSASQANYSMSHKGVSSTGSSMITSSSQMSAMNGQMLKLADLKLDDLKSLTAGSGQQEIEQTINKYSNMLTSIVSSLQEDERGGSAITVHDVGGKKSQYLEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQ--FSSAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEHLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGAENQEEMILRKVPMWLFPLAFHNDD-NIKYYACLAIAVLVANKEIEAEVLKSGCLDLVEPFVTSHDPSAFARSNLAHAH---GQSKHWLKRLVPVLSSNREEARNLAAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCP-NAIASKFAAQALRLIGETVPHKLSQQVPLWSVEDVQEWVKQIGFNDYIDKFNESQVDGDLLLKLNQDNLRADIGIGNGILLKRFERELQNLKRMADYSSKDTAKMHQFLSEIGTDYCTYTYAMLNAGIDKCALPHVNEDMLMTECGIHNSIHRLRILNAVKN-LENSLPSSSEENMAKTLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNGLLNSIRQAKNFVLVLTPDALHRCINDEDCKDWVHREIVAALNSNCNIIPIIDQQFDWPEVERLPEDMRSVAHFNGVNWIHDYQDACIDKLERFLRGEKNIDRIAAMVPGTPGSVSYQRMHSNDSDYQSGGAGAGSGAGTGGGGGGGVTGSVVDGLMVAANGSGQANHQANRYRQSPSPARQRGSTSQLSGYSRAPSKRSQILTPYRTQQAALLHKTGAGSASMQNMMPLAYLPPRRSSAAGLGHGSGSGMGSGYRSHSVDGLLDQAGSTPEQRIAAAAAKVTAGSTALTNASSTSTLQPEEEVTDAALNDSVTRRDKHTLSPPGNVQQHRKSRSLDHILSKQTLAELLPPSSELADGTQSMQNLAIPMTPQPQRRDTSSSSKSPTPERPPQPAMERVRERQSPEGVSATESEREDQPEECLRHGNQQRASASVHRGASLTSNKTSNSSLGSNFSAGGNNKTIFNRTMKKVRSLIKKP", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 248, "similar_positions": 242, "identity": "18.13%" }, { "cls_id": "homologset.agr.HGNC:17075", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U303-1", "uniprot_id": "TAB2_RAT", "id": "Q5U303-1", "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "aln": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGAARQTQQHSGWVSQFNPVNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTVHSSASSQS----------SAHSQYNIQNISTGPRKNQIEIKLEPPQRNS--SSKLRSS-GPRTASTSS---------------------LVNSQTLNRNQPTVYIAASPPSTDEMIS----------RSQPKVYISANASTGDEQGMRNQPTLFISTNSGAS--AASRNMSGQVSMGPAFIHHHPPKSR--VLGGNSAASPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETETIQHLTDPTLAHVDRVSEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENSLTRRRLKRSNSMSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKT-------QDTEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99K90-1", "uniprot_id": "TAB2_MOUSE", "id": "Q99K90-1", "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "aln": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQS----------SAHSQYNIQNISTGPRKNQIEIKLEPPQRNS--SSKLRSS-GPRTASTSS---------------------LVNSQTLNRNQPTVYIAASPPNTDEMIS----------RSQPKVYISANATAGDEQGMRNQPTLFISTNSGPS--AASRNMSGQVSMGPAFIHHHPPKSR--VLGGNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKT-------QDAEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NYJ8-1", "uniprot_id": "TAB2_HUMAN", "id": "Q9NYJ8-1", "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "aln": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQS----------SAHSQYNIQNISTGPRKNQIEIKLEPPQRNN--SSKLRSS-GPRTSSTSS---------------------SVNSQTLNRNQPTVYIAASPPNTDELMS----------RSQPKVYISANAATGDEQVMRNQPTLFISTNSGAS--AASRNMSGQVSMGPAFIHHHPPKSR--AIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKT-------QDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5RFW2-1", "uniprot_id": "TAB2_DANRE", "id": "Q5RFW2-1", "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "aln": "MAQGNQQIDNQVLHHLRQKFPEVPEDVVCECVLQNKSDLAACCEYLTKVSPRFLYSEGSQSLTD------LRNHMTQLNLGVSQNTHGAVQRDAVGMNGSRTLAPSVSDGPLNVPSALSEFYQPETPSVPTHTPASL---SMESTR-KPQPPQHLGLYQVG-GKGHAPPQAPRFNPITVTLAP--NTGRNTPTSLHIHGGPQSGLNSP--NSIYIRPYVTQP-GSTRQVQCRAQYSPTSQPA--QQIYQITHP---------------AAPQSSWSQHQTSHVYMPISSPTNTQAPSIPSAVASQAVSSSPLPSSGSSFSQYNIQNISTGPRKNQIEIKLESPQRGSGSSSLLRSSSAPRSACSSTSSSCPSSCTSLASSSGSSTPISIGGAGLSRSQPTVYISPSPPTAATAPSEDCALVPNTPRSQPKIYFSANTSADD-GGGRNPPTVYISANPALQGPAGLRALGSQMSMGPAYIHHHPPKSRPSVGAGGTATSPRVVVTQPNTKYTFKITVSPNKPPSVSPGVVSPTFEPNNMLSLPADHHYAEPEISQPDP---MRDKAVEPRRLSMGADDAAYTQALLVHQRARMERLWHELELKKRKLEKLKEEVNEMESDLTRRRLQRSNAFCQIPSIEEMQQLRCKNRLLQIDIDCLTKEIDLLQTRGPDFNPIAIHNFYDNLGFLGPVPPKPLKGPTKAEVSRTDAGVRVLSEPEEDDGVQWSCTACTFLNHPALNRCEECEFPRNF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****.:*** ****.********** **..*:***:.:* *** *:: *.*:**.**. .::* ******.***.:..:. *:. :******: *:*** *: .: .*::* *. :.*::.* .: .* *: .:.. ***:: . *.. . *:****** ***** :***.********* * . **** ********:* * *::**.* :: : . :* ** ** ::* :: *.. . **************..*.*:: *: :**: *:.**********************.***.. ** **** .**::.:*: :.. *.*.******:.***.: * *****:*:***:::.* ** **::**:*.. . *. * :..*:*****:********* . ...:*:*************************:*********** .*:*. * .: :* .** *: *.*:****:*************:****** :***::*:**:***.******..******:***::.****:*******. ** **************:*:***.*** ********:**:******* . : :..:* .:.*:::*.**.************ ***:**:**:*", "identical_positions": 390, "similar_positions": 177, "identity": "52.14%" }, { "cls_id": "homologset.agr.HGNC:17077", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BX07-1", "uniprot_id": "CTDS2_MOUSE", "id": "Q8BX07-1", "name": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2", "aln": "--------------------------------------------------------------------------------------------------MEHGSIITQARR-EDALVLTK----------------QGLVSKSSPKKPRGRSIFKALLCCFHTQHVVQSSSS-----------------------------------------TELT-HKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEQDQGRICVVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFREACVFHQGCYVKDLSRLGRDLRKTVILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPVFEELSGTDDVYTSLGQLRAP----------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0M8V0-1", "uniprot_id": "A0ABK0M8V0_RAT", "id": "A0ABK0M8V0-1", "name": "protein-serine/threonine phosphatase", "aln": "-----------------------------PRGRAAGLVSQALWNSLLGWGKGSKRCVFLGLLKQPAQTAEALPAPPPCQGHCITDPAVRLCAASSPPSLGPSAVLSAVKRGSLCLSVTASVQFPWQPHPRQRTQASGLVSKSSPKKPRGRSIFKALLCCFHTQHVSQSSSS-----------------------------------------TELT-HKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEQDQGRICVVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTVILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPVFEELSGADDVYTSLGQLRAP----------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O14595-1", "uniprot_id": "CTDS2_HUMAN", "id": "O14595-1", "name": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2", "aln": "--------------------------------------------------------------------------------------------------MEHGSIITQARR-EDALVLTK----------------QGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSS-----------------------------------------TELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP----------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PFN0-1", "uniprot_id": "HZG_DROME", "id": "M9PFN0-1", "name": "Phosphatase Herzog", "aln": "-------------------------------------------------------MDATSIITQVSRDDEQLNVYP-----------------SYPNDKDAWLGFSGSVWLPDCPADHA-----------------QLTHDVDRLKPQKRGLFHSLLCCWRRNRTKTNQNG-----------------------------------------TQID------GSTTPPPLPDQQRY---------LLPQVRLTDMHRKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLQKMGELYECVLFTASLAKYADPVADLLDKWNVFRARLFRESCVYYRGNYIKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLSKVDSVYSVLCNSNQPLNNQTNQQQHPQELQQAPNQLHQQLQQQQQQQTISATTVITQATTLSAPTMLNQQQTSPPSPQSELLQKT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07800-1", "uniprot_id": "PSR1_YEAST", "id": "Q07800-1", "name": "Phosphatase PSR1", "aln": "MGFISSILCCSSETTQSNSNSAYRQQQSSSLNKNRSVKHSNTKSRTRGVHQTNSPPSKTNSAATFSSTERSTGKSGISTNDNEKKKPSSPTAAVTATTTNNMTKVEKRISKDDLYEEKYEVDEDEEIDDEDNRRSRGIVQEKGDAVKDTSRQKKQQQQQQQQSQPQPQPQSQSQSQSQSQSQQRGPTVQVSSDHLIQDMNLSRVSSSSQASETSNDADDEDDEDEEYIDLTLLQQGQYHAPGYNTLLPPQDESTKGKKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLS-VKTSLDVGKILDVTI---------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q07949-1", "uniprot_id": "PSR2_YEAST", "id": "Q07949-1", "name": "Probable phosphatase PSR2", "aln": "MGFIANILCCSSDTSKTHRQ---RQPPETNHNRNRNRKHSSNKAQTQGRKQKATP---NGDKMQYSTPEILLSSSDSGSN------AGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMT-----EVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNS---SINDEAPPQQG-LYQVGQE----DMNPQYVASSP-----DNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKRPGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLS-SGNVLDVGSVLDVTI---------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . : . . .. . * *** : *:::************ : .***::.:**:. .*:***:*** *:***.::.:*:* *:****:::*.:*: * ** .:: *****:* :.* *:*:*.::** * . :*:***********::*:*:.***.* * ** ::**::*.** . ", "identical_positions": 84, "similar_positions": 65, "identity": "16.9%" }, { "cls_id": "homologset.agr.HGNC:17078", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99JD4-1", "uniprot_id": "CLAP2_RAT", "id": "Q99JD4-1", "name": "CLIP-associating protein 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVP-APKTPGNPVNSARKPG------------SAGGPKAGGTSKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAG--AAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSAVAGRVSVGGSKASPLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDG-TASEDGR----VRAKLSTPLVAVGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGAQRILVNSASAQKRSKIPRSQGCSREASPSRLSVARS--------------SRIPRPSVSQGCSREASRESSRDTSPVRSFQPLG---------------------PGYGMSQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNG----------------SIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGK--------------------VFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSE---TRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRS-PANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRG-VTEAIQNFSFRSQEDMSEPLKRDPKKEDGDTVCSGPGMSDPRAGGDAPD--SSQPALDNKASLLHSVPLHSS-PR-SRDYNPYNYSDSISPFNKSALKEAMFDDDADQ-FPDDLSLDHSDLVAELLKELSNHNERIEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRHQPAR--FKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIG-DELKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTTDVSGQS---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BRT1-1", "uniprot_id": "CLAP2_MOUSE", "id": "Q8BRT1-1", "name": "CLIP-associating protein 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVP-APKTPGNPVSSARKPG------------SAGGPKVGGPSKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAG--AAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSVGGSKANPLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDG-TASDDGR----VRAKLSTPLVAVGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGAQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARS--------------SRIPRPSVSQGCSREASRESSRDTSPVRSFQPLG---------------------PGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNG----------------SIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRIELKRLCEIFTRMFADPHGK--------------------VFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDITRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPRDFTNSSE---TRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRS-PANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRG-VTEAIQNFSFRSQEDMSEPVRRDPKKEDGDTICSGPGMSDPRAGGDAAD--GSQPALDNKASLLHSMPLHSS-PR-SRDYNPYNYSDSISPFNKSALKEAMFDDDADQ-FPDDLSLDHSDLVAELLKELSNHNERIEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRHQPAR--FKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNMLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIG-DELKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTADVSGQS---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75122-1", "uniprot_id": "CLAP2_HUMAN", "id": "O75122-1", "name": "CLIP-associating protein 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMGDDKSFDDEESVDGNRPSSAASAFKVP-APKTSGNPANSARKPG------------SAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAG--AAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDG-TASEDGR----VRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARS--------------SRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGALYAPEVYGASGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADAL--------KKPARRRYESYGMHSDDDANSDASSACSERSYSSRNG----------------SIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKR-------------------VFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSE---TRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRS-PANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRG-VTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATD--SSQTALDNKASLLHSMPTHSS-PR-SRDYNPYNYSDSISPFNKSALKEAMFDDDADQ-FPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPAR--FKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIG-DELKPHLSQLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NYW6-1", "uniprot_id": "CLAP2_DANRE", "id": "Q6NYW6-1", "name": "CLIP-associating protein 2", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALSLSQDRSFDDDDSVDGSRPSSAQAAFKVPKVPKKPAESASSSRRPS------------ATGAAKSG-ASKEG-AGAVDEEDFIKAFTDVPTVQIYSTRDLEDNLNKIREVLSDDKHDWDHRANALKKIRSLLVAG--ATDYDCFYQHLRLLDGAFKLSAKDLRSQVVREACITVAYLSTLLGNKFDHGAEGIVPVLFNLIPNCAKVMATSGTAAIRIIIRHTHVPRLIPLIASNCT-SKSVAVRRRCYEFLDLLLQEWQTHSLERHAAVLVESIKKGIRDADAEARVEARKAYWGLRAHFPGEAESLYNSLESSYQRTLQSCLKSSGSVASLPQSDRSSSSSQESLNRPLS-KWSAAP-----GRVPAG-SKSSGSPASLQRSRSDVDVNAAAGAKARHSG-QAGGAGRVTTG-LTPGSYASLGRLRTKQTLSTASSVGSSQVDSRGRTRSKMASQSQRSDDSDCTPGSQSATPVGAGSRSGSPGRVLASTALSTLSTGAQRVSAAPG-SHRRSRIPRSQGCSRDSSPTRLSVAPSNISHIYNGSKGARGSRIPRPSVSQGCSREASRESSRDTSPVRSFTPLG---------------------SGLGMSQSSRLSSSVSAMRVLNTGSDVEEALADAL--------KKPARRRYDTYGMYSDDDANSDASSACSERSYSSRNG----------------SIPTYMRQTEDVAEVLNRCASANWSERKEGLMGLQALLKNHRTLSRVELKRLCEIFTRMFADPHSKRDPRGFGTVESGISSASFKRVFSMFLETLVDFIAVHKEDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFTILMRFTVDQTQTPNLKVKVAILKYIETLTLQMEPQDFVNTGE---TRLAVSRIITWTTEPKSSDVRKAAQSVLISLFQLNTPEFTMLLGALPKTFQDGATKLLQNHLRNTGNTAQASIGSPLTRHTPRS-PASWSSPLTSPTNTSQNTPSPSAFDYDTENMNSEEIYSSLRG-VSQAIQNFSVRSQEDMTEP----PRKREGD------------GGEETVD--SGRTALDNKTSLLNTMPLLSSSPRPSRDYQPVNYSD--SSFGSSSFNKSLKDADQEESLTDDSGVDQSEVVAELLKELSNHSERVEERKAALCELMRLIRETQLHVWDEHFKTILLLLLETLGDGEHVIRALALRVLKEILNRQPWR--FKNYAELTIMKALEAHKDPHKEVVRAAEEAASMLATSISPDQCIKVLCPIIQSADYPINLAAIKMLTKVIDRLPKEGLIQMLPEIVPGLIQGYDNSESSVRKACVFCLVAIYAVIG-EDLKPHLSQLSGSKLKLLNLYIKRAQSGSSGSDQSSDVGGQGL--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NBD7-1", "uniprot_id": "CLASP_DROME", "id": "Q9NBD7-1", "name": "CLIP-associating protein", "aln": "MAYRKPSDLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVCTDMGFLIDGLMPWLTGSHFKIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRERPTRMIKRPLHSAVSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQLNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPETRR---------------------TVSRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTGAAASGSLPRPRLNSN-------SGGTPATTPGSVTPRPRGRAG---VSQSQPGSRSTSPSTKLRDQYG---GIGNYYRGATGAIPKKASGIPRSTASSRETSPTRSGGGLMKR--------------------SMYSTGAGSRRTPERNNPVRPSAAAR------------------------------LLAQSREAEHTLGVGDDGQPDYVSGDYMR-----SGGMRMGRKLMGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK--------------------VYSLFLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSSPKPLQSPSVGPFASLQSHHHQLSISSTSPRSRQSSVEQELLFSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLERERTTQNAKSPTDDAKVITVSINMAENGELILASNLMESEVVRVALTLTK--DQPVELLQTSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQHS-KEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSSTKNSSAASSS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .. *: . :* .** : . .: . .:* :: .* . . * **** :.* .:* ** ::*: :::::: ::: ::**.: **::*.:******:**: . : * .* . ..: ::*****:******:*::*. * **:* . .*: *:**: *.***:*::. *:: **::**.*:*: : :.. . *** :* *:: **::****::***:*:** :::**.* ***.:** .:* :* .:* *** *: :*.:*: : *::*: :..*. .: . :. :..: : *. ... . ** *::**. :*: . : : : . . .. **: . . . : . .. . . . .: .**** **. * . * . . .:: * **** ..**::**:* . . * .: .**.:.. ..***. . *:.* .* :.*..*.* : ... . * . * ..** :*:***.*****:.* . .* :*: ::: ***::*****:**:.* * : : *:: :** : ::* :** *.* * *:*:**:*:.::* ** ::*::***:***:*::*:*:***.*:::*: *:*::.:* **.:**:. *:*: *.****. *.::***::: *: . :.: . :* :: ::: ** ::*. *:* *::*::****::*:**. ***.:**.* . ::.*:*. .: ::. .** : . * * .** ..* : *. ::. : . ....: ..* **: ::.*:: . :. . . :: .... :..:. :: . *: * .. . . .: *. ..: . : : : .: .*::* *. . .: :* : :* :* : . : ::**::*: :**: * . : .*:** :*:. : * : :: ** ::* ::.::.. **.:* :. . :*.*:. : .*::: *:* :.::* **.***: :* :: .* * :.*.* :. *:::* ****.***:* :: *:* :.:**:** *. **::***:**:: :. .*.. ::. .. . ", "identical_positions": 321, "similar_positions": 466, "identity": "20.02%" }, { "cls_id": "homologset.agr.HGNC:17079", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JV04-1", "uniprot_id": "GGA3_RAT", "id": "A0A0G2JV04-1", "name": "ADP-ribosylation factor-binding protein GGA3", "aln": "-----------------MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQIN-KELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVS-PKYLGDRVSEKVKAKVIELLFSWTLALP----EEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDEE--KSKLLAKLLRSKNPDDLQEANQLIKSMVKEDEARIQKVTKRLH-TLEEVNNNVKLLHEMLLHYSQEFSSEADKELMKELFDRCENKRRTLFKLASETED-NDNSLGDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGNQGALIDLAELDTPSSSSPVLAPAPAP---------------PTSGIPILPPPPQ-TSGPPRSRSSSQA---EAPSGPDSTNNALSLLDEELLCLGLSDP-----APTAP-KESAGNSPWHLFQNEPSSDLDFFSPRLVSAASCPSEGSLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAEPEGPEYP----SSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPARPLLPFSTGPGSPLFQSPAFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQL--STELGEVDQFPPVEQWGNL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BMI3-1", "uniprot_id": "GGA3_MOUSE", "id": "Q8BMI3-1", "name": "ADP-ribosylation factor-binding protein GGA3", "aln": "-----------------MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQIN-KELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVS-PKYLGDRVSEKVKTKVIELLFSWTLALP----EEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDEE--KSKLLARLLKSKNPDDLQEANRLIKSMVKEDEARIQKVTKRLH-TLEEVNNNVKLLHEMLLHYSQEYSSDADKELMKELFDRCENKRRTLFKLASETED-NDNSLGDILQASDNLSRVINSYKTIIEGQIVNGEVTTSTMPDSEGNSHCGNQGALIDLAELDAPSNSS----PALAP---------------PTSGIPILPPPPQ-TSGPPRSRSSSQA---EAPPGSDSTNNALSLLDEELLCLGLTDP-----APTAP-KESPGSSQWHLFQNEPPSDLDFFSPRPVPAASCPSDGPQLPPPVSTSSMSQAPLPAAFPAPVVPASAPTHSTGSFMFSSGPAPALAPKAEPKGPEYP----SSSTSHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASAPARPLLPFSTGPGSPLFQS-----QGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQL--STELGEVDQFPPVEQWGNL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NZ52-1", "uniprot_id": "GGA3_HUMAN", "id": "Q9NZ52-1", "name": "ADP-ribosylation factor-binding protein GGA3", "aln": "-----------------MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQIN-KELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVS-PKYLGDRVSEKVKTKVIELLYSWTMALP----EEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEE--KSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLH-TLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETED-NDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTP---------------PSSGIPILPPPPQ-ASGPPRSRSSSQA---EATLGPSSTSNALSWLDEELLCLGLADP-----APNVPPKESAGNSQWHLLQRE-QSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVK--------PTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQL--STEVGEVDQFPPVEQWGNL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4ISY9-1", "uniprot_id": "A0A0R4ISY9_DANRE", "id": "A0A0R4ISY9-1", "name": "", "aln": "--------------MRIMAFPEGESLESWLNKATHPTNRQEDWEYIIGFCDQIN-KELEGPQIAVRLLVHKF-CAQEWEALQALTVLEACMKNCGRRFHKEIARYRFLNELIKVVS-PMYMGNSISEKVKSKIIEMLYSWTVAFP----NEAKIAEAYQTLKRQGLVKSDPELTVDKTLIPSPPARPKNPVFDNED--MGKLLAELLRSKNPEDLQEANRLIKNMVKEDDARVHKLTKRIN-TLEEVNNNVKLLTEMLSQYDRERSSDADRELIKELYERCDKLRRTAFKLATEAED-NDSSLGDILKANDDLSRVISCYKRIVEGQADDGEAEELRPAANEACESG--TGTLIDLAGLDEPSSPPPPPPPAPAPTLAPAPAPQISLATQKASSIPVLPPPPRRLAGAHGSQTSSPN---HKAAEHQSS---LSLLDDELLSLGLNDPPS---VPNRP-KLDDLSAQWTSLQAP-DPGLDLFGSISAPSAVFPS--THTPAPTSHTLTHAQGLQELSVLDFGGEKSVCGASGIAGGAFGQSAAVMCSAAPLSSSNP------FVSAPLSGSPAVSRAQAVTG--------------------GSAPGSPFFQPFSSP-SHSLQS-------SPARSSEPSLTNLHVPLEAIRPSKVLPVTMYDKDGVRVLLHFAMDCPPGRPDVLVMVVSLLNTAPLPVRNVVLQAAVPKSMRVKLQPPSGTEICPFNPILPPASITQVMLLANPLKERVRLRYKLAYLLGERQ--YSEVGELDQFPPADRWGSL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1NCV9-1", "uniprot_id": "A0A8M1NCV9_DANRE", "id": "A0A8M1NCV9-1", "name": "", "aln": "-----------------MADPEGESLESWLNKATNPSNRQEEWEYIIGFCDQIN-KELEGPQISVRLLAHKIQSPQEWESLQALTVLEACMKNCGGRFHNEVGKFRFLNELIKLVS-PKYLGDRVSERVKTKVIELLYNCSVALP----DEAKIAEAYHMLKKQGIVTKDPEVHVDRTLIPSP--KTKNPVFDNEE--KSKRLAELLKSKKPEDLQEANRIIKNMVKEDEALQQKVSNRVS-TLEKVNNSVKLLNEMLSHFKTDESTQEDKELLKDLYNDCDNLRTAVFRLATETED-DDSALGDILHASDDLSRVINSYKKIVEGQTIVIDVPASTPSGCINDRSS--SEILIDLADLGSGTPSPLRHGLTPPQHS-------------DSPAADLLTLTSLMGAQPSSSNTSSGSSSFQTSPPSSQLPSSLSLLDEELGSFGLGSLDSNSRTSAEKTTKEAQSNQWISSQIS-NPVTDFLCS-STPLNPPNSAAPPTSKTTSITDFENSLQQSFKDLVLLDLDKTKSLSNYSSLSSRELAAGKENIHPALNTLS-------LSAGITPLPSAGSSAKPQS---------------------FAPDSPVFR-SLSPTLPSSQS---------SSGSDISLTSVFVPLEAIKPSKECPVTAYDKDGVRVLLHFATDHPTGRPDVLVIVVSMLNTAPLLVRNVMLQAAVPKSMRVKLQPPSGTEMAPFNPFMPPSSITQIMLLANPLKEKVRMRYKLTFILGDQP--VTASGEIDQFPLVEKWCHL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38817-1", "uniprot_id": "GGA2_YEAST", "id": "P38817-1", "name": "ADP-ribosylation factor-binding protein GGA2", "aln": "MSHPHSHSIYLSELPVRKPQALGNPLLRKIQRACRMSLAEPDLALNLDIADYINEKQGAAPRDAAIALAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQRLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESDLAVLKPSNQLKTASEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKIMAGFKEDNAVQAKQAISSELNKLKRKADLLNEMLESPD---SQNWDNETTQELHSALKVAQPKFQKIIEEEQE-DDALVQDLLKFNDTVNQLLEKFNLLKNGDSNAASQIHPSHVSAPLQQSSGALTNEINLIDFNDLDEAP---------------------------------------SQGNNNTNGTGT--------PAAAETSVNDLLGDLTDLSISNP-----------------------------STANQASFGLGGDIVLGSSQPAPPVTTTNNSNNTLDLLGLSTPQSPTNSQAVNSSGFDLLMGFNPTTGTTTAPARTLVN----------------------------------------------------------------------------------------------------------QSPNLKIEFEISRESNS----VIRIKSFFTNLSSSPISNLVFLLAVPKSMSLKLQPQSSNFMI-GNAKDGISQEGTIENAPANPSKALKVKWKVNYSVNSTQ--AEET-AVFTLPNV------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q06336-1", "uniprot_id": "GGA1_YEAST", "id": "Q06336-1", "name": "ADP-ribosylation factor-binding protein GGA1", "aln": "----MPQRIELTSEPVRKPRSTESSLLRKIQRACRSTLPEPDLGLNLDVADYINSKQGATPREAVLAIEKLVNNGDTQAAVFALSLLDVLVKNCGYSIHLQISRKEFLNDLVKRFPEQPPLRYSKVQQMILEAIEEWYQTICKHASYKDDLQYINDMHKLLKYKGYTFPKVGSENLAVLRPNDQLRTPSELQEEQERAQAAKLEELLRSGKPDDLKEANKLMKIMAGFKDDTKVAVKQAINNELNKLKRKADLFNEMLTSAD---EPDLENEAIQELYGDLKSAQPKFKKLIEEERD-DDALVSNLSKFNDLVIQLLKRYKSIKG--------MKEEELNVPDTNEP---AKELNLIDFDDDTTA---------------------------------------------NTPSVTS--------PSKSLQPFDDLLGDFNKVSLSSP-----------------------------KSPQENDTVVD---ILGDAHSKSSGIDLLDFDSQPGES--KTALSAYSNSIVLPNG--LLNSSSNSKEITAQSQRHILN----------------------------------------------------------------------------------------------------------QSDHLRIDYELTRESMT----KLRLVIFYSNISSDPITNFALLVASPKGTTLSLQPQSGNMLQ-SNSRDGIKQIASVEGISVNLGKPIKLKWKANYCTKGDS--KEES-GTTSLPTI------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9W329-1", "uniprot_id": "Q9W329_DROME", "id": "Q9W329-1", "name": "", "aln": "------------------MTTDESIMEEMLERATNPAQKIDELGVQM-FCIVVK-SNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEECMTQCGDDFQDEASKFRFLNELIRLVS-KKYKGAETPHEVKQRIMECLLLWTTEFP----QRQKIRDAYDMLRKEGDIEHG---------TTEAAVAKRESVLGTID---EAMFAKLIKSNNPENFKRANLLLQYRMAQ-EARRNDLLAQHRLVLCEVQETMQLLNQMLDTYDP--ANQDVSETLHELYKSCKKHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASSVKSTASSTTATTSSNNAQLLNELLGDLLID---------------GSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELFQQILPTQDRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATATATVDSIDDVPLLS--------DDVEKKDEAVVAPVTVVP------------------------------------------------------PAKPLSEINVELDNIQATGE-QRIVLDDDDMQLSLNFTSDRPGHR--VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGDDPDPIKESIVAKGIDYVD-----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : :::* . : : : .. :: .: : : : . : : *:::*: :.:** :: : .: .***:*:: .. ..: :* . : * : : *: :* .. . : : : .*:: :*::::.** ::: : * :::.. *: :** . : * ::*. . : :: : : : : . . : :. :: : . . . : . . . : :. .:: .:: : : * : : .. : : * : * . :.. : .. : : : : : : ", "identical_positions": 26, "similar_positions": 135, "identity": "3.31%" }, { "cls_id": "homologset.agr.HGNC:1708", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P05541-1", "uniprot_id": "CD8B_RAT", "id": "P05541-1", "name": "T-cell surface glycoprotein CD8 beta chain", "aln": "MQPWLWLVFSVKLSALWGSSALLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERV--KKNMTL-SFNSTLPFLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVVDVLPTTA-PTKKTTLK---KKQCPTPHPKTQKGLTCGLITLSLLVACILVLLVSLSVAIHFHCMRRRARIHFMKQFHK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P10300-1", "uniprot_id": "CD8B_MOUSE", "id": "P10300-1", "name": "T-cell surface glycoprotein CD8 beta chain", "aln": "MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDP-KDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTA-PTKKTTLKMKKKKQCPFPHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A6NJW9-1", "uniprot_id": "CD8B2_HUMAN", "id": "A6NJW9-1", "name": "T-cell surface glycoprotein CD8 beta-2 chain", "aln": "MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMCIYWLRQRQAPSSDSHHEFLTLWDSAKGTIHGEEVEQEKIAVF--RDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLK---KRVCRLPRPETQKGPLCSPVTLGLLVAGVLVLLVSLGVAMHLCCRRRRARLRFMKQFYK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:* ***::: :*:.* ..*.* ***: : ****: . :***.* . *****: * . .:.:.***: *:** :** * :: : :: :*.: .******.:*** **** :.**.**:*:***.***** ****:*** *: * *:*:**** *. **.***. :*:**. *.**::: * *****::*****:*", "identical_positions": 101, "similar_positions": 61, "identity": "46.98%" }, { "cls_id": "homologset.agr.HGNC:17082", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ABB2-1", "uniprot_id": "D4ABB2_RAT", "id": "D4ABB2-1", "name": "", "aln": "-----MNTSCWKSITQRPALPTAGPQQSAMTREGQ-FREELGYDRMPTLERGRQD--------AGRQDTGSYTPDTKPKDLQLTKR--LPPCFSYKTWVFSVLMGSCLLVTSGFSLYLGNVFPSEMDYLRCAAGSCIPSAIVSFAVGRRNVSAIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIISARSSEEPCKKKKVGLPQLPPHAPEGSISDGTNILDEVTFPARVLKSYSVVEVIAGVSAVLGGVIALNVEEAVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLITISSLTSPLLFTASGYLSFSVMRIVEIFKDYPPDIK-SYDVLLLLLLLLLLLQGGLNTGTAIQCVSFKVSARLQAASWDSQSCPQERPAGEVVRSPLKEFDKEKAWRAVVVQMAQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VHK5-1", "uniprot_id": "MLC1_MOUSE", "id": "Q8VHK5-1", "name": "Membrane protein MLC1", "aln": "-----------------------------MTREGQ-FREELGYDRMPTLERGRQD--------AGRQDPGSYTPDSKPKDLQLSKR--LPPCFSYKTWVFSVLMGSCLLVTSGFSLYLGNVFPSEMDYLRCAAGSCIPSAIVSFAVGRRNVSAIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIISARSSEEPCKKK------------KGSISDGSNILDEVTFPARVLKSYSVVEVIAGVSAVLGGVIALNVEEAVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSVMRVVEIFKDYPPAIK-SYDVLLLLLLLLLLLQGGLNTGTAIQCVSFKVSARLQAASWDPQSCPQERPAGEVVRGPLKEFDKEKAWRAVVVQMAQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15049-1", "uniprot_id": "MLC1_HUMAN", "id": "Q15049-1", "name": "Membrane protein MLC1", "aln": "-----------------------------MTQEP--FREELAYDRMPTLERGR-------------QDPASYAPDAKPSDLQLSKR--LPPCFSHKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKK------------KGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T7H1-1", "uniprot_id": "A0AB32T7H1_DANRE", "id": "A0AB32T7H1-1", "name": "", "aln": "MHYLGTASSLLRCVPVAVYVIHWCLMDLRMQREEASAQEVFSYAQMSTLERNSGVGTLSRHLERERLERDGYTVDVRASDLQLDQPGPLHPCFSYRVWLYSVVVGSSLLIASAFSLYMGNVFPAAMDYLRCTAGSSIPAAVVSFAIAKNRQVAVSDFQLVYVSSFAVTTTCLVWFGCKLAISPSAININFNLLLLIVLEVLTASTVILSARSVDNCCSHS-------------KPVSEGPMIVTQTSFPTRLFKAFAVIELIVGIAAVFGGIIALNLGALLPEPYLSVTFFWILAACFPSAIASHVVAENPSKSLVEMLIAINSVTSPLLFSASAFLSSSVISFIEIFLHEVALAKQSYDILLLVLMLLLLVPAVLTLATIIQCASYKSQVRMGANEWDTLR--KKHCEQLASNGTLRDFDKEKAWKAVVVQMAQ", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :* :* :.* :*.****. : .*: * :..**** : * ****::.*::**::**.**::*.****:*****: ******:***.**:*:***::.:.. .:.:**:::**:********:****** :.**********:**::**:* *:***::*** :: *.:. .:*:.. *: :..**:*::*:::*:*:*.*::**:**:****: :. *:*********.***********.** ***.***:**:*.*:******:**.:** *:: .:*:* . . * ***:***:*:*:**: . *. .* ***. :* ..*: . .**. ::: . ...*::*******:********", "identical_positions": 193, "similar_positions": 129, "identity": "44.37%" }, { "cls_id": "homologset.agr.HGNC:17083", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A1A5P2-1", "uniprot_id": "RRS1_RAT", "id": "A1A5P2-1", "name": "Ribosome biogenesis regulatory protein homolog", "aln": "MEGQSVEELLAKAKQEEAEKLQRITVHKELELEFDLGNLLASDRNPP--TVLRQAGPSPEAELRALARDNTQLLVNQLWQLPTERVEEAVVAR-----------LPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKT-NLVWDEVSGQWRRRWGYKRAR-DDTKEWLIEVPGSADPMEDQFAKRIRAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKR-----KFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKKKGGRQGPSGRRKGGPPSQGEKRKGVLGGKKHSRPPALGGKKKGVPHHGGKRRK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CYH6-1", "uniprot_id": "RRS1_MOUSE", "id": "Q9CYH6-1", "name": "Ribosome biogenesis regulatory protein homolog", "aln": "MEGQRVEELLAKAEQEEAEKLQRITVHKELELEFDLGNLLASDRNPP--TVLRQAGPSPEAELRALARDNTQLLINQLWRLPTERVEEAVVAR-----------LPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKT-NLVWDEASGQWRRRWGYKRAR-DDTKEWLIEVPGSADPMEDQFAKRTQAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKR-----KFQPLFGDFAAEKKNQLELLRVMNSKKPRLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPSGKRKGGPPGQGEKRKGGLGSKKHSWPSALAGKKKGVPPQGGKRRK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15050-1", "uniprot_id": "RRS1_HUMAN", "id": "Q15050-1", "name": "Ribosome biogenesis regulatory protein homolog", "aln": "MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPP--TGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVAR-----------LPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKT-NLVWDEVSGQWRRRWGYQRAR-DDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKR-----KFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8I937-1", "uniprot_id": "Q8I937_DROME", "id": "Q8I937-1", "name": "Ribosome biogenesis regulatory protein", "aln": "MD--VVKEVLAKH-QKELDKYKPITVEKHLECRLDVGSLLITDPND---FDDRELRDNKEEYLTALTRENTQLLVNAIWELPTERVDESIVAK-----------LPEPTTVLPRLRKPPGPRPLTKWEKFAKEKGISKKKKD-KKTYDETMDKWVPTYGFKRAEAEKAKDWVLEVPQNADPNTDMFQKKIDLRNEKVAKNEIQRMKNIVRAKKIDMPRSGYLGPEAASS-SQLLTAVTVAKSSTASVGKFQNKLPKEKEARGLGIKELIPGGKRKQSHITQTPEKEANLDLIKSVLNKKPKLDVSKAVSMEKRDNRLAREAEAE--NEPGK-KGGKK-PKG--KGSRKAVGKKSKGNRGQRAP-------GKK---AQAGRKRR-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q08746-1", "uniprot_id": "RRS1_YEAST", "id": "Q08746-1", "name": "Regulator of ribosome biosynthesis", "aln": "-------------MSAEDYKNLPVTVEKPIPVVYDLGNLAAFDSNVLDKNDLDSSNARREEKIKSLTRDNVQLLINQLLSLPMKTTTESVGGTGGQSSVMTLLQLPDPTTDLPREKPLPKAKAMTKWEKFAAKKGIKPKERAGKMIYDEASGEWVPKWGYKGANKKLDDQWLVEVDD----------------KVKGTDNELIDPRTLNRAERKRLVK----------------------KNEKQQRRNMKNAL-----------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * * :**.* : *:*.* * * * : :*:*:*.***:* : ** : . *:: . **:*:* *** : * .:.:*:*::** *** *:: : :**. .:* :*:: *. . .:*::** : : :.**: :.: **.: : * .. . .::: * ", "identical_positions": 51, "similar_positions": 62, "identity": "13.25%" }, { "cls_id": "homologset.agr.HGNC:17084", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6ZWQ0-1", "uniprot_id": "SYNE2_MOUSE", "id": "Q6ZWQ0-1", "name": "Nesprin-2", "aln": "---MAASPVLPTEDGEGFLGIDDLHFSLQAEQEDTQKKTFTCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLKNRSIKLINIHVADIVEGNPSIILGLIWTIILHFHIEKLAQTLSCDYNQPSPEVVSVAASSPTSSPP---TKKCSKAQAQARWQWSAKKALLQWAQEQCARS-ESVNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKIPKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPG-----------------------------------------------------------PGDSTQAKVRDALVWLTLQEKRFQKMLKDSASETYCNKYHSLLSFMESLNEEKESFIDVLSLKGRMGELNEDESRLRQGWTSLMHQVAAWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTLIQGKLSSFKSLMGSFDYHSDVLMAFQSNAEKSLPAVPPVKLEEMTRRIN--NVLGKNFIPLLEFHDSKCSVLALLDEAKAKLDVWNGTYESKESVEVLLEDWHKFTGEKKFLIQLDASFQKCEEMYKN------SARECESIREEYMMLEKNVHSCRQYIHNTKATLQRALMSWATFEEDLALLKASFDLTKK----EQIKEVPVETLLQWNTKHTSLNEVGSFLIGVSSREVAASISKELRRLNKRWRKFITKTPL-LKLPLVK----IQDQPPGNSSGTSLSKE----------------------------------SAMAAEPGGSRGEDVKAAEKQEVEDEESAGQL---KVNEEVEGLIKQVTIWESQTKSILDLLQHGDHADG-SSADTLQHLIAKGSVYEELLARTEDTLQMDVQSPSNLEPFQNVLRAGLQAKIQEAKQGVQITMVELSAVLKNLSDEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LELDLGLKVEEAQKELEVSILRAEQLLGQRERPGGFLLKYKEALEILNTNSLAKYLRAVEELKRTVPGGAKLQLEEQSRVASAKWEPLRHEISLYLQQLKIAIEEEKLRDNIARLEKQINKEKKLIRR--GRTRGLRKEHEACLSPESIKCQLEHHVGVLRVLCEELTSPEDQQELKRALRDYEQKIARLLKCASEIHTTLQSSQGGALEERSALITTENGRRDAD-----GEVPLEIPDNQLSTEKAMEPIKNFSQTSELKPQQEESIMEKEGKDCSASLSDLQERYDTQRGLLEQHLQDSKSRVTSDFASEQE-----RSSACLQSKLAELQVLLADTDAHWEKFEITSLNLRRLMSD--AEKPVLNQERDLLKGNEQVLHGLLNTRMESLEMALQIVLPLEKECSLLCASDLPLCTVAVQDLHPVEIDGVYQNLRDIRDSIAKQIRVCTSLEEPS--NSVPRELHTLDQCAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAELPADRPAP---KAPEVLS------EDILLMKEKAGPLDERLRTLGINIKDAEGGENTTCERLVGALSVNLVAMDG-----QSKEEGPPEDKKLLEACSSKNLELFKNIQDLQNQISKIGLKDPTAPAVKHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWESTKASVTESLEQCGSALELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKIAEIETVKEEFSDHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLGRALALWDKLFIIKNNIDEWT--EQILGKAESHELTEEDRGRLKEELKVLEEQSAEFSRRVADIQSLLQSNEKPLELQVMESSVLSKMKDVKTHVAGGSNSY-APSGSTAELREDLDQAKTQMGMTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELS------------ELKRQYASVSNLFNTK-------------KNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDFLTLGGGNSKIQQVETVLQH------------VKMLLPKAHVKELDSWLRSQELELENMESICQARAGELNNSFQQLLRLEDDCRSLSKWLTNQEENWGKMEVSGERMDLFSQALTRKREQFETVAQLSDSLKEHGLTEGEETIKESTHLIDRYQALWRQLHEIEEEDKLPAAEDQSFNDLADDVIHWIKEIKESLMALNSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAEHCEAP---------LAQETFTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKED-LRLMLTELKKQQEAG--FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKHLHESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSSTLDDISKEYFSLCDGSKDQIMAKERMQKLQELESRLRFQGGALKKASALAKSIKQNTSSVGQKIIKDDIRSLKYKQKDLENRIESAKQETENGLNSILK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSSTEKHVKFSLPVEEMPATSEVPKPTRESAAVGESGGARETNTNSAVEMILSKQLSLNVQESMQN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQDEREVNELQNQPLELDIMLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEQLKGMEELSTHLEARRAAIELLEQSQHLNQTEEQALVLPAARPSVCHLGSLQQELHTLKK-------------------------------TKERQYGLLSGFQDQLVMAEASLNTSLAEVESLKIG-SLDSATYLGKIKKFLGSVENQQGSLSKLRTEWAHLSSLLAAADQKLVESQ-MKHLEHGWELVEQLAHRKCFQQATEHSELTCLLEKLQDLKVSLHQQQQRLTLSLNSPGQQAA--IVDMVTPAAELQAIKCEFSGLKWQAELHMKRLWGEKDKKTLEDAINNLNKQMEALEPLNR---EVENRIKKCELQNRIKETLSWVKNTMAELVVP---IALLPDNILSQIRKCKLIHDGILGNQQAVELLVEEVRGITPSLAPCEGDGLNALLEDLQSQHQALLLKSTERSQQLELKLEEKSKLFAIIGKVQLTLE--ESETLMSPTG-DRASTEAELERRLAILKASQQQLQDTESALSAHLQELTNAYKDANVFERLFLDDQLKNLKARTNRTQRFLQNNGSELKQKMESYREFHDKAAVLQKEAECILHGGLLPLRQELEQDAKEQLGNLRDKLAAIRGSLSQVLTSEEVFDTIGLSWDGSLLARLQTQVLEREREVEGKIKQLDTFLIARDRHQASISKIRAVDLQIKKGAESLLKVPSMSPESTLLNAQTLIQKIEKSKRLRDEIIRKLSKNE-AFDDSFKESEMQRLKLCAEENSRLQEALQNMLLELQPREMGEKEFREKLENALHVLKQIQSRLQQPLCVNLGVQHIQHEKETWEAFGEQVEAEMCGLRAVRITE-EQREENDSGTGGMEAKLRDIEGLHMELSKSISLRADVLNDAYDSANRYDELVAGALRIITSLEATLLSYRVDLHNPQKTLELAHLKQEELQSSVADLRSLTETLGAISSPEAKEQLRCTLEVLAAKNSALKAGLEAQEAEEERCLENYKCFRKMKEEICSRLRKMEMDLGQSIFPLPRSYKEALARLEQSKALTSNLLSTKEDLVKLRQLLRHLRCRSTENDATCALGVASALWEKWLSLLEAAREWQQWGGELKREWKFISEEIEREAIILETLQEDLPEISKTN-AAPTEELWQLLDSLCQHQESVEKQQLLLALLLQRVRSIQNIPEGTETGETIPALQEIGSMQERCDRLLHTTRKNKDLVQAEIQAQQSFLKEIKDVKRVFEQISTSFPNLAPEGHPERAEQFEELRSILQKGKLSFENIMEKLRIKYSEMYSIVPAEIGSQVEECRSALEDAEEKMSSEVSKSSPSSIMRRKIERINNGLHCVEKMLQQKSRNIEEAHEIQKKIWDELDLWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKMEEYNDLLKSTEVWIEKTSCLLANPACYDSSRTLSHRASTLQMALEDSEQKHSLLHSIFTDLEDLSIIFETDDLIQTIHELSDQVAALQQQIMEALPHVQQVADDVVAIESEVKAMEKKVAKIKAILLSKEIFDFPPEEHLKHGEVILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVFQRTSQLLQDVKLLENVTQEQNELLKVVIK--------------------QTAECDEEIDSLKQMLTNYSAEISPEHVSQNQVADLPSLQGEMERLEKQILNLNQKKEDLLVDLKTAVLNLHEHLKQEQQEVGDK--PSAGASECTVAERDASERKLSRTNSMSFLPVVKEEAEESSVKSEDGRRRTEPPSASWSFLGKHSKDLEGDGASSSSSATIVQDADGRISTCDSSMVHIIAPDSGS-----------------------TEEGPAPSPRLSQTDEGATPPIEAALLDFPREQGAFESTVERSRPRPADILRVCKTQVAKLELWLQQANVAFEP---ETVDADMQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGTTQQEAEALSWKLKTVKCNLEKVQMVLQEKFSEDQHPSTLKKPSEP--HDVDQPAGLSELDSVLTERPQFSRQKDAPQPQILELKPSEQKDLIKFTELNAKKTWLQGHQENEDANRQSASSSKVPSPGN---AASDSTLPLQAQSGDKWQYLHHELTSRPNPSVPQLVEPQVALTTSTLPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEETYISLDKRLFELFLSLSRCLG-SVEGLLQRPGLLREDACAQQVFFQKLALELKKLYLALGDKKDDFLKAVTWPGKEATLLPECIDALTVSLESVQSRAAWRDASLKAGLEHSRSYQNEVKRLYSQLIKKKTALQQSLNEISGQSISKQLQKADVHTAELQNSEKQVAKLRDEGERLRFPHGLLQDVYKLEDVLDSMWGILRARYLELSSPFLSKSLQ-TLLQGMAELVSIGKGKLAADPLQHAKSKAALQAQLQDHKAFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSMLQKWEEFDDNYASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQTLNEGRQLAASVSCPEP-------EGQIARLEEQWLSLNKRIDQELHRLQTLLKHLLSYSRDSDELTRWLETSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMSTGNQLLHLKEADT-----------------------------------------------------------------------------------------------------------ATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISWMNAVEPQAAGKDTELS-KSSASQVKHLLQKLKEFRMEMDYKQWVVDFVNQSLLQ-LSTCDVESKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEERLKMLQKPESAVSMEKLLLDCQDIENQLALKSKALDELRQSSLT-MDGGDVPLLEDMASGIVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAVLSLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKA-SCPSMAGIIEEKCQDAHSRWTQVNQDLADQLQEARGQLQLWKAPHNAHAEAAAWLQQQEAKFQQLANTNLSGDNLADILPRALKDIKGLQSDLQKTKEAFLENSTLSDQLP-QPEERSTPGLHSGQRHSLQTAAYLEKMLLAKSNEFEIVLAQFKDFTDRLAYSKDLIVHKEENLNKLYHEEKEEVPDLFLNHVLALTAQSPDIERLNEESLRLPLSDVTIKTLQSLNRQWIRATATALDHYSELQGNGLN-EKFLHYCERWIQVLEKIQESLSVEVAHSLPALLEQQKTYEILEAEVSTNQAVADAYVTQSLQLLDTAEIEKRPEFVSEFSKLSDQWQRAARGVRQRKCDISRLVTQWRFFTTSVEDLLRFLADTSQLLSAVKEQDCYSLCQTRRLVHELKSKEIHLQRWRTTYALALEAGEKLRNTPSPETREFVDGQISRLQESWKDTELSLGEVISRLQSTAETWDQCKKKIKKLKKRLQALKAQSEDPLPELHEALHEEKELIKEVEKSLANWTHSLKELQTMKADLSQHILAEDVTVLKEQIQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQT-ADVSIEEMIEKLQKDCMEEISLFTENKLQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDNQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASKLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAEDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIEDPREIQADSWRKRRESEEPT-------SPQSLCHLVPPALGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEDDEE-GPFYSALS-----------------------GKSISEGHPWHVPDSPSHSKHHYKHMEGDRTEAPVPTDASTPFKSDYVKLLLRQGTDDSKEG---LKEAQQE-DEQLATLTGQQ------PGAFDRWELIQAQELHSKLRLKQTVQQLKSDIGSIAAWLGKTEAELEALKLAEPPSDIQEIALRVKRLQEILKAFDTYKALMVSVNVSHKEYLPSQSPEATELQNRLHQLSLSWDSVQGVLDSWRGDLRQSLMQCQDFHQLSQDLLLWLATAESRRQKAHVTSPEADRQVLLECQKDLMRLEKELVARQPQVSSLREISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLQEQVAQDLMSLQRSLDPDASLTSFDEVDSGEQLPAAFAKSPRPRWT-FLEEEEEEEETDSRMPHLDSPGSSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPMLRYTNGPPPT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZNW6-1", "uniprot_id": "A0A8I5ZNW6_RAT", "id": "A0A8I5ZNW6-1", "name": "Nesprin-2", "aln": "---MADSPVPPTEDGQGFLGIDDLHFSLQAEQEDTQKKTFTCWINSQLAKHAPPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLKNRSIKLINIHVADIIEGNPSIILGLIWTIILHFHIEKLAQALSCDYNQPSPEVVSVADSSPTSSPP---AKKCSKAQAQARWQWSAKKALLQWAQEQCAGL-GSVSVTDFKSSWRNGLAFLAVIHSLRPDLIDMDSVRHRSNQDNLKEAFRIAEHELKIPKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPG-----------------------------------------------------------PGGSSQAKVKDAVVWLTLQEKRLQQMLKDSESETYCNNYHSLLSFMESLNEEQKSFTDVLSPRERMEEWSEDELQLRQGWTSLTQQVAEWKAQLDDALPSPLKEMEAWLKAVEGLVEEGVPTSQNYSEARTLIQGKISLFKSLMDSFDYHSNILLSFENRAEKNLPLVPPAKLEEMTRRIN--NVLGKNFISLLEFHDSKCSVLALLDEAKAKLDVWNGAYGSKESVVVLLEDWHKFTGERQFLAQLDTSFRKCEEMYKS------LARECGSIKEEYVTLGKNVHRCRQHIHDTKATLQRVLASWATYEEDLSIVKASLEATKK----EQIKEVPIETLSQWNAKCTSLNEVGSFLIDVSSREVGSSVSKELRRLNKRWRKFITKTPLELKLPLMR----VQDQPSVNSSGTSLSKE----------------------------------SAMSAEPGRSHDEDIKAVEKQEAEEEESAGPLNVSKVSEEVEGLLTQVEIWGSDTKSILDLLRHQDHEDG-SSSDILQYLIAKGSEHEELLARTEDALQRHDQSASNLESFQNVLRAGLQAKIQEAKKGVQMTVVELSAALRNLSDGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LELDLRLKVEEAQRELESSIARAEQLLGQRERPGGLTSKYKEALEIFNANSLAKYLQAVEELKCTVPGGVKLQLEEQSRDACAKWEPLRQEISLYLQQLKIDIEEGKLRDNIAKLEKQINKEKKLIGR--GRTRGLRKEHEACFSPESIECQLEHHVGVLRVLCEELASPEDQQELKRALRDYEQKIERLLKCASEIHTTLQSSQGGALKERAALITTENGGRDAHGEAAHGKAPLEIPDNQLSTEKAMEPIKNFSQTSELKPQQEESILEKEGKDCSASLNDLQERYDTQRAILERHLQDSESRVTSDFPGETE-----RSSACLQGKLTDLQVLQADTDACWDEFEVTSLNLKSLVSD--TEKPVLAQERDLLKGSEQALHVLLNTRMESLEMALQIVLPLEKECSLLCASDLSLCTVAVQDLHPLEIDGVYQNLRDIQDSIAKQIRICTNLEEPS--VSVPRELHTLDQCMIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAELPANPPAS---KTPEDTPAVSSAEEDILLMKEKARLLDERLRTLGINIKDAEEGESTTCERLVGALSVNLAAMGG-----QRKEEGPTEDKKLLEACSSKTHELFKNIQDIQNQISKIGLKDPTAPAVKHRKKSLLRLDKDLDGFEEEMVHIQKMASSLPQFKDGSEKVVIQQCEDTAALWENMKASVTESLEQCGSVLELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKKAEIETVKEEFSNHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLGRALALWDKLSNIKNNIDEWT--KKVLGKTGSHELTEEDRERLKEELKVHEEQTAEFSRRVADIQSLLQSNEKPLELQVMESSVLSKMKDIKAHVTGASNSS-RPRGNTAELREDLDQAKTQMGMTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMTILENQIGCLTPELS------------ELKKQYASVSNLFNTK-------------KNALQDHFATFLNEQCKNFNDWFSNIKTNLKECFEPPETKLSMEQKLQKLSDFLTLGGGNSKIQQVETVLQH------------VKMLLPKAHVKELDSWLRSQELELENMESVCQARAGELTSSFQQLLRLEDDCRSLSKWLTNHEENWKEVEASGERTDLFSQVLTRKREQFETVAQLTDSLKELGLTEGEETIKESTHLIDRYQTLLRQLREIEEESNLPAAEDQSFNDLAHDVIHWIKEIKESLMALNSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQMPLEERIQKIKEIIALKAEGDAKIQTVMRRAEHCETP---------LGQETLGDLSKQWDSTLLLANAYLSHQEKLVLEGEKYLQSKED-LRLVLTELKKQQEAG--FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKHLHESLLQQLQDSVQKLEGHVQEHSSYQVCLADLNATLDDISKEYFSLCDGSKNQIMVKERMQKLQELESRLCFQGSALKKASALAKSIKQNTSSVGQKIIKDDIKSLKYKQKDLENRIKTAKQETENGLNSILK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSSAEKHVKFSLPAEEMLATCDVPEPTRESAAVGESQGGRETSTNSAVEMILSKQLSLNVQESMQN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQDEREVNELRNQPLELDIMLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEQLERMEELYTHLEARRAATELLEHS-QLNQTEEQAAVPPTARSSGCHLGSLQQELLTLKK-------------------------------IKEKQHGLLSGFQDQLVVAEASLNTFLTEVESFKIG-SLDSATYLGKIKKFLGSVEKQKGSLSKLRMEWTCLSSLLTAADRKLVESQ-LRQLELGWELVEHLAHRKCFQQATEHSELTHLLKRAQDLTVSLHEQQQCLTLSLN-AAEQAE--VVDMVTPAAELQTIKYEFSGLKRQAELRMKRLWGEKDKETLDDAISNLNKQLEALEPLNR---EVENRVKKCDLQNKVKETLSWVKNTLADLTAP---IALLPDDILSQIRKCKLIHDGILGKQQAVELLVEEVRGIAPSLATSERDGLNTLLEDLQNQHQALLLKSTQRSQQLELKLEERSKLFAIIGKAHLTLE--ESETLMSPMR-ERASTEAELEPRHATLKAFQQQLQDMESSISAHLQELTNAYKDANVFERLFLDDQLKALKTRTNRTQRSLQSNCNELEHKIKSYRELHKKTALLQKEAESIQHGGRLPPHQELKQDAKEQLSHFRDKLAAIRGSISQVLTSEEVFDSIGLSWDSSLLERLQTQVCERERELEERVRQLDTWLIARDRYQALLSKVRAVDLQIKKGAESLQKTPSTSPENTLLKAQTLIQKIEKSKRLHGEIIRKLSNNE-AFDDSFKESEMPQLKLSAEENSRLQEALQNMLLELQPKEMGEKAFQDKLENSLHVLKQIKSRLEQPLCVNLGVQHIQHEQETWEAFGEQVEAEMCGLRAMSVTG-EQREENASGNGDMEAKLRDIEGLHMELSKSIDLRTGVLNDAYESATRYDELVTRAARIITTLEATLSSFRVDLHNPRESLEQARLQQKELQLVVADLQGLTEALGAISSPEAKEQLHCTSQALATNNSAMKAGLQAQEAEEERCLENYKCYRKMKEEICSQLRKMEAELGQSIFPLPRSYKEALARLEQSKVLTSNLLSTKEDLVKLRQALRRLRRRCTENDATRMLGVASALWETWLGLLEAAREWQQWNGELKREWKFISEEIEREAIILEDLQEDLPEVSKAKDTAPTEELCQLLDSLRQHEESVEEQQLLLVLLLQRVRNIQNIPEGSEAEETIPAREEIRSMQERCNRLLQTAQKNKEAIQTEIQARHTLIKEIRDVKHLFEQISASFPNLPLEDHPERAEQFEELRSILQKGKLTFESIMEKLRIKYSEMYSIVPAEVESQAEECRRALEDADEKVSSEVSKSSPSSVMRGKIQRINNGLQCIEKMLQQKSRNIEEAHEIQKKIWDELDIWHSELNELDSEVQDLVEQDPGQSQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATVKMEEYSDLLKSTEAWIEKTSHLLANPACYDSSRTLSHRASTLQMALEDSEQKHSLLHSIFTDLEDLSIIFETDDLIQTIQELSEQVSTLQQQIVEALPHAQQVADDVVAIESEVKSMEKKVAKIKAILLSKEIFDFPPEEHLKHGEVILENIHPMKKTIAEIMTYQVELRLPQTGTRPLPVFQRTSQLLQDVKLLENVTQEQNELLKVVIK--------------------QTAECDEEIDNLKQILANSSAEDSPERTSQDQVADLPSLQGEVERLEEQILNLNQKKEDLLVDLKAAVLNLHEHLKQERP-GGER--PSAGTSECTVAERDASERKLNRTNSMSFLPAVKEEAEESSVKSDDGHRRTELP----SLLWKHSQDLEGDEASSSS-ATIVQDAGGRISTCDSSMVHIIAPDSGS-----------------------TEPGPEPSPRLSRTEEGDTPPIEAALLDFPREQEALEATVERSRPQPADVLRVCKTQVAKLELWLQQASVAFEP---ETLDTDMQQVVEEELAGCQAMLTEIEHKVASLLETCKDQGLGDCGTTQQEAEALSWKLKTVKCNLEKVQMMLQEKYSEDQQPTTLKKPSEP--HDVLLPASFSELESVITERPQFSRQKDVPQPQILELKPLEQKDLIKFTELNAKKTWLQCYPEDKDANRQSASSSEVPSPGNSDSETSDSALPPEGQSGDKWQYLHHELTSRPNPPAPQLVEPQVAITLSTLPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEETYISLDKRLFELFLSLSRCLG-SVEELLQRPGLLQEDASAQQVFFQKLALELKKLCLALGDKKGDLLKAVTWPGKGAMLLPECFDALKVSLESTQSKAAWRSSSLKAGLDHSLSYQNEVKRLYNQLVKKKMALQQSLNEISGQSIGKQLQKADVHTAELQNSERQVAKLRNEGERLSFPHGLLQDVYKLEDVLDSMWGLLRARYLELSSPFLSESQQDALLQGMAELVSIGKEKLAADPLHQAKSRAALQAELQDHKGFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSLLQKWEEFDDNCASLEKDLEVLISSLPSLSLVEETEERLLERISFYQQIKRNIDAKHARLCQTLNEGRQLAASVSCPEP-------EAQIAKLEEQWLSLNKRIDQELHRLQTLLKHLLSYSRDSDELTRWLESSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDEKSSLKSAVMSTGNQLLHLKEADT-----------------------------------------------------------------------------------------------------------ATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISWMNTVEPQVVGEDAELP-PSSVSLVKRLLQKLKEFRMEMDYKQWIVDFVNQSLLQ-LSTCDVESKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQYLEQLLESITENENKIQNVNSWLEAQEKRLKTLQKPESAVSMEKLLLDCQDVENQLAVKSKALDELRQSSLT-MDGGDRPLLEDMASGINELCQKRNSVTSQVHQLRASVQTVLQEWKACDKLYDEAHMKTAQLTYSMEHSKPAVLSLQALDCQVQNLEALQDEAENGERSWEKLLEVIGRLKD-SCPSIAGIIEEKYQDAHARWTQVNRDLADQLQEARAQLQLWKAPHNAHTEAAAWLRQQEAKFQQLANTNMSGNNLADILPRALDDIKGLHRDLQKTKEAFLENSTLSDQLP-QPAERSTPGLHSGQRHSLQTVACLEKMLLAKLNEFEIVLAQFKDFADRLAHSKDLIMHEEENLNKLHHEEKE-VPDLFLNHVLALTAQSPDIERLNEESLRLPLSDITMKTLQNVNRQWIRATATALDHYSKLQGNGLN-EKFLHYCEKWIQVLEKIQESLTEDVAHSLPALLEQQKTYEILEAEVSINQTVADAYVAQSLQLLDTAEVEKRSEFVSEFSKLSEQWQKAAQGVRQRKCDIGRLVTQWRFFTTSVEDLLRFLTDTGHLLSAVKEQDCYSLCQTRRLIHELKSKEIHVQRWRTTYELALETGERLRDTPNPETREFIDGQAGRLQDTWKDTELSLGETISRLQSTAETWDQCEKKIKMLKKRLQGLKAQSTDPLPELHEALQEERELIKEVETSLANWTHNLKELQTMKADLSQHILAEDMTVLKEQIELLHRQWEDLCLRVAVRKQEIEDRLNSWIMFNEKNKELCAWLVQMENKVLQT-ADVSIEEMIEKLQKDCMEEISLFTENKLQLRQMGEQLMKASSKAKAAEMEEKLSKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDNQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASKLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAEDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIEDPREIPADSWRKRRESEEPA-------SSQSLCHLVPPALGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEDEEE-GPFYSALSDVEIPENPEAYLKMTTKSLKASSGKSISEGHPWHVPDSPSHSKHHYKHMGGDRTVAPVPADASTPYKPAYVKLLLHQGTDDSKEG---SKDGTQQGDEQLATLTGQQ------PGAFDRWELIQAQELHGKLRLKQTTQQLNSDIGSIASWLEKTGAELEALKSAEPPSNIQEMALRVKRLQEILKAFETYKALMVSVNVSHKEYLPSQSPESTELRNRLHQLSLSWDKVQGVMDSWRGDLRQSLMQCQDFHQLSQDLLLWLASAESRRQKAHITSPEADQHVLLECQKELMKLEKELIDRQPQVSSLQEISSSLLVKGHGEDYIEAEEKVHVIEKKLKQLREQVAQDLMSLQGSLNPDASLTSFDDVDSGERLATAKFG----------EEEEKEEETDSRTPHLDSPGISQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPMLRYTNGPPPT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WXH0-1", "uniprot_id": "SYNE2_HUMAN", "id": "Q8WXH0-1", "name": "Nesprin-2", "aln": "---MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPP---AKKCS--KVQARWQMSARKALLLWAQEQCATY-ESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPG-----------------------------------------------------------TGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRIN--NILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKN------LAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKK----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIK---KQDQPTFDNSGNILSKEEKATVE--------------------------FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQL---KVAKDVEKLIGQVEIWEAEAKSVLD----QDDVDT-SMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRR--GRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPH-----SEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEK---DYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEED-----RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVND--IKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG--NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHG-----YGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWT--EKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCH-ALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELS------------ELKKQYESVSDLFNTK-------------KSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKH------------VKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAP---------LVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKED-LRLMLIELKKKQEAG--FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDERKVNELQNQPLELDTMLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKK-------------------------------NKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG-PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQ-IKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAG--NQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL---EAENQIKKCDIRNKMKETILWAKNLLGELNPS---IPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQ--ESETLIIPRV-ETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRN-ELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK-TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIE-KQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIK--------------------QTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSS-GTIVQEAYGKISTSDNSMAQILTPDSLN-----------------------TEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVEP---ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN---DVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLS-SVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPEL-------EGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDT-----------------------------------------------------------------------------------------------------------ATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHS-PSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQ-LSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLT-LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKG-LCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLP-QPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQT-ADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-------SPQSLCHLVAP--GHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE-GPYYSALS-----------------------GKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQ------SGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVP-----GSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32T5Q1-1", "uniprot_id": "A0AB32T5Q1_DANRE", "id": "A0AB32T5Q1-1", "name": "", "aln": "MASQRTSGDPFAERGSLPLDIDDVHILLQVEQEQIQKRTFTNWINAQLSKRSPPVTVVDLFNEFRDGSRLLDLLEVMSGQRISREKRRGTFQHRSNIEKALAFLKKKSIKLVNINVSDIMDGKPSIILGLVWTIIMHIHIEELASTLSFSSRQSSLESLASLDTRSTNSSARSSPVPPRGSPLHARFRVSAKKALLLWVREQCQRAGCTLNVKDFKVSWRSGVVFLAILHALRPNIVDLTRARTRTNRQNLEEAFHIAERELHIPRLLDPADVDVRDPDEKSIMTYVAQFLQYSKDASVSDEEMQFLTPPQRLSPVNLPSDFTPSIAASPVRQAHLFIPCPIKSGSPQSPEIAVKSAAPGTSTNQKAQEVTCWLDQAYQELIEGWDSTEGESYAERYQVFHTFIVSFNEQRRPVMPLLTAMKRTPQLSAEQKALRRSWDTLAEKLREYKTELDLTLPSPLDTVGRWLLRIEEVLSAEETEPMDHARAAEEAREKLEILKVCLEEMPHHIKRFNTFQNTNEFGETLVPTDKMEEMKRRFTSVRVTAKYHGIKLEYRERRHTVMDLLNQLNVKLRSWKRAYISQEAVRVLMQDWNETVNKQELTSLLDAALQRLKLIANKYTSKAALAGDSTQVNHQVADLEADVTATLEGVRMVRGTMGRVLAAWDSYSDIYTSLRAWLEQGPHGQRHGQRTEVTSSVMSEWSSRQAHLNDVASYLIEVTDPQTSRAISDELCRINLLWADFAKTSQFYLAEEPRAAPSSPQTVQALMREATQLLKEPVEVVSGSLRTYTKRLQLMMKKIKDVDLEAIIPSLDCSPETLSKLQQAIPEVLQTLCEAEQVCDELR--VSVSGLDGRLAELLHWEMEARELYHLLKKEIHKQKRGQVPQARVLISRGLQLEGQVVMEEQDLQVMVMSFQKSSPLQYLIASTMQDRVRAAVEKSQEAVGMLSSLGSCRDRSPSRDQPPSKIFVLYQEAEKESQTSQSGATSQPETQPTVRAKVPISSQMPSEVPSVVLKTQQCSQPVPMIVVQDYEAEKGSPQSQIHPCEQEKDCQSIELKSQKVVEAQAKSHIVKEHCVESQTTQQLAENQRQVQAPIPSQPSQNQQKVASQGHHEQQLTTQAHVQIQQQDKTQSSKQQMVQGLMSTQPQLQDQLEAQPQKDITGQNQAPKQKRKSKKSQANLQNRPWLQQRSQLENVTPKTAQEVPQSQPKPVYKGQISSQAPPQQIVAVSPTEAQGPPQSSVTAQPKYVVESDEKCLKQNQPVAQEKVTQRLAQTEPVVPAQPMTQKQPQQSMTVTNHQVLSQPQPAILTQAQAALKTAHAAPIQQQKQPHMVKSQQPDVMIPKQAQPQFMTPMQPQVMPQWQPQQTILQSHPAVPQPQRFTVAQAMPQGISRPVQQYPTPPMQPQMIMPRQQSPHGAVQTQSQILHSPTVLAPQSKGASPIQPRIISMPQSQMPVQTQTQPQLKAQGSAPLMTQPEGQPLWCPPRDATQNYPKIQGPVSAQMQPLAHFQTHPQPQSFPPAQPQQWSPTRPGIVAQTYPTVPGQAVQPQPQLSVYPKTQPQPQPQQWLSPRPESPWGQSQIRPQGPVQPWRPVSPESVSPVYPRAETQGQGLHPQSQYQPLPRPQSPQRQWGPVRTEHQFQVSSQTTLHGVPHPIAPWNQPTVKAPIRPQSPQQPQQSQQQWGPSRTDAPSESLIQSQAFQGEFQPQDLTKPQLPVQEPPQQQSTPRVKQPALAQAPPQAYTEAYKKAQALVRDRFEEAKHCLQEHILEAISVFKDKRMTDEQVSVKEETLRSLDPELLEEFLRAAEGMEAFCTPSELRDMEFFTQSVRTQWKVVRLEISEFVRQLRFELTHLHFNCLVEACERHFKKERLSFSP--ESIG------EACFSTEGSLAEAGKQLEALKELCDTLSPEDAHRLAQAQLRECERRLAAIQRQFSGDAETPAPDTGSQTEQAKEPQT----------------------QKAPTIPPPVEKPKEVNIPEGVIPVSPQRPRTVEKREIVKQTSTEEDRYRSSRFALQGQLNRNEQCMLGDHPSES------VTPTDLQKRLRELKSLWDETESLWKEYETMCMQCVQYNER--AVEQDRMELTVRWREQKSQLQGRVDSLGAALELMDSITLKISEISEKLDKFIKEPKDIKG---YTLANPAILRDVKDLDESIQTEMDRLSRFD------SEPSHLELRDRSPLTQVVLNHRSSLDRLRQQVRKSDAAARALDRFLMSLRTVELDVTSVLSAPSNDSMVLQDSRSKLALIRKGVSSLKDKAPQLDQLLG--GAQLEVTQDGSPVCCLDMVGVLVHKVEEADDR----LMIRQNEIQKEQQNQGLGLRRKTMQTELRKVQGAAEKQGLKDPTMPAVQHRIRALSDLELQLNCLRPEYESIKVAVSELSENENPD-----PAEEELDFLWEETERAVSDRLEQCTVLMELLKKFQNCRTYLTNTLQRAEQTSSEQASYMGKDNLQRLLAKVVGIKEDLNGLGPKMEEFRSVCRQLQSQLKKIPDCSETPFETEADALVDSWLDVSEKTDGYLDNLRVGLELWEKQLVLGGEVESWASTKLIIFSESHPFSSEEEVLSMKNEIQSQEDNLEHFHRKLLEIQELLQSKESPLELQVMETNLRKKMEQVKELFTDCTDVFQELVKVKAHLIEKIESYQSSVENIRSSVNMFSSEDRLELETHLQDLCEQLLDQEEQTESLLKEINLMSSITGPQVLEELTNQSKRLKDSIAETRETIRQK-------------KEQGEKSFLQTIKEEFQSFEEWLQDEQLSVNECFENPERKQDVETSMQRLKGFLESKDGEQRLALLKDRFESG-----------GQTKVPSEAQALFSTWHQEQEGELATLRAHCQGRHKQLDDILYNLNSLQEEHNHLKDWLQQREQ----VPEQREKLRQIQEEFLKESGRVEAFNDLLSTVRMRGLR-GDPFLKDSETLIDQYHSLGVILENQAQDHKTLDAQIETFQTNAEQIRAWIRDLKQGLEHLSTDTPMQEKDMKAQAVLNQSSDGDAKLVALKGEGVALCTHEILEETRRQELVHTLKNIEDEWKRVLDLAQLLKHQAELQDTLHRELENLQAQEESTQSWVREQLQMLRSLEKELQPQEKLNKLLAVLDLADEADSRLASLQRQGQSLCSYKELDTERRSHIDQTHRAIEEEWRKVLQLAQELKNQVKHEESLNRELQSFCDQGEETQSWVRQLRETLETLHMTSSIQEKLSGVEAVLAHRSEGDYKLSDLKMKGESLCSYEDLQEGKRQTIQQTLQEVMQEWTEVLLNAQELKNQSELEESLCKDLLDLQEQEESIQSWINEQHLKIKLLGEDTQIQEKMNGAQGILNSESEGDYKIATLRRKVDGLCSRENLSEDRKQEVQLNLRSVEEEWKKVLAGAQQLKNQAELQDSLARELQTFYAQEESTWSWVRNQKDVLYSLGENTHGTQDQLEERLSRAQAILSLYSEGNSKIADLKKTTDHLYSRDDLDEDTRHSLVNKMKNIEEEWKATLQQAHKLQSLLKGLVERLVSCQCQKEQ-LQSRLEQVKEQISALPRRFPWPGLGDRRHTVEQAKSLLDRTRALNPSLSAVRALGREMSQLTRDSNWIDPSWATMEECIPVLIKELTEFCVNLEEEIRRERVCAQLVEQHTMAQDWLREQVKCFGALPTERHGLQGSINTLKALLQTVDREKREMKELNAVKDSLMDLCTPGGCDALTLEVSHLHDLCVSSEKEMRERLAVCEARLNDIDRRLAGRAQILREQAEGLLDELRAQDHSLGFLVASQNITQLQENWHSFKTCERDIEALEGKVRDLGQALRTVPIDEEPPSDVISIVDTVTQQYCSLRSKLSERQNDCADSTVQCVRQALQNIQSWNQMANANPPTSSATSMQTAIEEGAKLRKSLQVALSHKELLRDCLGPDLAGKLERDGLKTLSEADAYMNDIKQELRNLQEKVEQEALRLSLEAQNIQVHSQVSTVTPSTKESDQLELVSFSSFINESCKTTDYSEQAKVQLSESLDSNIPTCVISETTTEAEVHTARISPPIIEKDVKTSIPQIATELLSESDTNVYESDVPASSYGANEGENEKLISVALETKADENADKEMPTSSCAAPDSLETTVQDTDIWSRGITSLSANGQESQMSFEVVGSDFFAERVEGESIQAVIAEPNKEEEGSYISHSLEEPVRDSVAQTKKVASLILDEDTVCIQSLDIPPDSNIARTDSASAMVNEKTVSLQTMGKQDEESLAPIEAEISERAIEAIPLPYFPNEAGVISLSEISSTVEAKQLTDIDPNREVQTPAETQDSGDAASRGIGTFSSDNGPNATIADSEGSWTTNNGPREIQRRYIILDLPEGVEMQRHHAHEGTSLSGSSETQIQGSGHSVAERMETEDEAESAETETGALVSTNTVLEAPEQHK----------------TIEADQNLSTRQVEEDMHVILDKDTRKTPSMDKERFIETDSKLKPSVKQPNEGETEVQTNKVDISVTPEMKPEGNKAIDVILEADTMASSGGKAKSTVIEPKLTPLFQQLTDRDTEIQSKRMNVIMTPEETNKAPLVDEAQIMESIPKLMPPVKRQDSKTDVQSNKINASMQEEKAENEKGMEVIKQETSSGVKAQSIKVKPTVMQWNDQETEIQSKQLYVSQDGKAKDEQTIQIAEEKDMYMTPLCEKTHSIEAEPRPTPPVRRKNDNKVDAQSYKMNISTTSEDRPENVETMAPSDTKTKALKAESEPTPPVRQRNEGKTDVKEQFSTTPEKTPESGDTVHMTMEEINKSTSADEAQSIETVTKPTPPVRRQKDDETEVQLDMADVTPTPPTRRRKDDRMSLNLESQIQGEVLPTPPNRRRREKLRSDRFSFDIESQPTPPARRRRDDRRLSLDLETQPTPPGRRCKEKDDQRFSLQLDTQPTPPARRRKEKEQQRLPVDLEIQPTPPSRRHKTKLGSETSSYSDVMKSMDLQTVEGKDCEDRRLSTDLETQPTPPSRRYKTKLGSETSSYSDVMKSMDLQTGEDKDSEDRRLSIDLVPQPTPPSRRQKSKPESKTSCYIDVMKNMDLQIGEDKDSKDRRLSIDLETQPTPPSRRQKSKPESETSCYSDVMKSIDLQTGEHKDSEKSIVKPTPPVRRKISPAESDVTLAICKKQEEIETIVKPTPPTRRKDSNEIIPGSSKLKDEPTPSLRRKDSQAETEMVSIVMVEDVLPTPPTRQKKDQLAEKDPLMAEEPQVIPGSTTNSESEDVSVCTKMEVEADVEPITKQEDEDELNLEPLIGQRQHEERKDSDTLLPEPISQAEIINESQPLDQDLDASPQSGLSTEIIESSAKEKDEPEGPTMKDIFTEIQQMTEKGPNNVLMEGLPYESTENLFDTCSTDLEARLKRLVFHLLELRSCPAALNSTDMAKQLEEAEECRKSAQIHVSIMSSQDQVNGVISAGTNGTVHDPEGMQQLSAQWSAALWDAASSVHSKEAQLQIVADFDRQTQKVKATLERLRSEREGLKTSPAVSSFAEEERLHTFLRSMEQERTVLGDLIQTHAKLSPHLSLPEKQAAEIQ-QNSLQNQWRALEKDAEIALYMVTAYAKESGSLLQEVSALKDHLQDTQKTLDALKSSPVLWDGKRAQDNMKINADLTSSHQQYLHFQQTSDMLAQKFQFKEEASSIEQHLQHIKHQLDQMGEQLASATPISSNPMLNKIVKVMTDALAWAKQTECDVKGRQKKVSLLPEEVHRQIRDLKKLQSEMSSKKTQLKALVEEVGELINGLDEADISMVNSSLANLEDLSKSTERKLAEAVREMESGLQTREKMSEQIADVDSWVVGHLRREALRRED-FQSLSLADLDRRMRQIQDTLGEAEKQSSVTEALLMKSKDIASELSVLESTELNKKLTNLQEDIKGVVIYEKACCQKVIDAKQSQESSQRKVSSLEFSLR-----------QMLVDVKRHRFPVTKDSLSVIEPFKQMIVERKSQVEQVSP-----CAEDKRRELLCVISELHYKMIDLDLKAQAHEKYLSLIEHVEQLKEEMEAQIPRTKDE-SINKEERYRACQTLLIHIPLIRLLCEETRDELHEIIADLYPSQLSAEQKRLKQILEGIRTSELAVNNNLQILEWDLLKQIHYPSEKTVLQQFLKDTNEELEKPYSVEPKDRVIEKQLRKFIVLKRNVESRIRVLEFLEKKIGAQLPEDSTLTYMKDMILQKCDQRMVGLTEAKELLRNYTKSVIN-------TIRFLQRAELVLLPSICSARSCSERLKDTQQALLTLDTEFQSHISQLQSQIPQHPCFKPNETECLHTEVLSQLLVRISSLKAQALIQLESLKRCVECQKHSRKCYEELCQQVRDSETLLSQCASKKITSHKDCKDQQLKLKALVEDVATLPGKLENLREWCLLYGCRANREE------AASAIWGQVARLQRCADDLHTRSEQMEAEWSNVTRSVEHAVAVMEQVSAELPDSNKDN--RTADELQELLLFWSQYQDRLDCEHRAVSALELRAARLLGVPPYLEQAPSIELCQQLQALQERYHSLKERSTQGQRTVRTEVEERERVQEQLEGVREWLDSAVSLLSVLEQEPS---KKQLQEVHSQLCTRKAVLQRISESLKMMYSDKNTSIPEEIEGLLQEVSQSLQEVEEQVKTAIEKSGPLHRLGAKISEIKAGLGSVQSWLEQKSLNFPEAEVTQKRVWDELDGLHTCLAAVEVELQDVSEMHPDETRLILDNLVNSQQTHTRLTKQAEQRTTFLSKVRDWLQEHDDMVKGSQSWISEAQSWLTTPCTYTTARCLDSHVNALQMVLDDSAQMRRTLQGFGGVLTEMGSVFDVSPLEEQLSNADRRVADMQHNLLGPLSQLEHAAAEVDAIESEVKVMEKDVAKIKSTLTTKEDISQ------DSLKATEDRIDLMKRTIAEIQNCKDGLCLPDKAENTLLVFKRAELLQKQLLELEQLALEYTIEVQETSDRPLCTTLLSAPPLSAPPLSVPPTITEEETQESGQIQIVHVEEDVLKKSGASLMTVEQSTPEQRLTWISERNSDTLTETQQEFEEEEELYEDAGDWEEDASEEDNDIYEDCMKTEDEELTMEVSADVVSSTEQILEIAETTDSKVEVESPSASGTTTPEALSEVDSMMESQSLPADMELGAWRGEQTAHTSDTQTYKTNNHPESQAPPTDEGVGGALEQTQLEETLWVSQNFRKPRQEHHTHTQEQSGTHDTLITHPEKTDSLAASTSLAVGEAGDWSRWMSTDGLLHVCRERAEQLEVCLHRAQVSLEDSRQQAQDSDMQHNIEQQLHTCQTTLVEIEQRISSLPPCGLKE------QEQHEAESLNTKLQLLKNRLVTVQLQLQDRHSNHQVCVERQRPLQAR-----LTRSASVQEMLSSSRTKLFRQSSLQQQRELEHGLNEQRDLTKAIAIQGSRTQTHNQTTDEHTGALAANENDDKREEE------------ELAVHRKWTHLCSRLKAEETEQDHGDNNQVESEILGPSVCLWSGDAVSLCLQEIQSSITQLKELQSSAATQDHQS---------LDEVLFEVLSGVNLTLRSLTHTLVFQPATSHTDTLNQLQQLQSLSVELISLESTLSSQGSEIMKLLVSSS-SVSETSTCFDLLMQHVCDIQKTLAEKQEQLQERIKHTTQHQKKAKDLHDSVLTNTLILHSTTNGEIHHDLYTQLQAVTRQKQEVEQTEKELAELRDETKSGDQPSSLTQQISTLEEVLESVWSDLEQRCGALQWTLDQQQMSRKILKALQMLLNLGKEKLTSMPQIELGNTAQLQTQLNTHTSFFQSLSGHLRRLQQLSVRMPHSASSGWETEVSEIECQVSSVLQQAQAVGTLLHSALQVCSHWDENQSWLETLLERLETQLPMMPLWEQTEEQLSQSTSVYKNVLAVLEQNRAQISLVLDEGRRQQEQVSSNDVGVPVHIVGVSTARLEQRLATLQKRVEKGLESTLHLKKIWKRYQSDSDALNEWMRRARELLDSWRDHMTAGKQEVDALS-QFQHFTEFCKELEVKSSLKASVVSSGSLILLLSEREQNTETQKISKITDPPRTSTPPGNTTVSEDLQPSETGRSVILDNNPEESSSVDVTLTPETTTSSIHNITEGTLSPTERSESNEGVISEEPTSPAFDLSVKQERVLSPVLLTLQFQLSQVEQDWVEIQTHIPSVQQGLHLSVRQSLSPEGLLADVSGWITGAESRLQMNESEGHNICTASELTHLLRAYQGLKREMACEQMSVDFINQCELK-QAG----TSRYKHTAFAEGLGHINLRWQTLQAHLNTQIQHTEDQMRIFAERDNKLQLLQCWVKGQKEWMRLAERPISHSFAEKCLKDYEELGEKLKAKFSEIAEMRKLATE-EDDRD----KDFLSKAKKLSQSLTDLCQQNTVLGNILKDLCKVWSQFECGRSQAMVNTVRIGQSLEYCQAPLPSLSALQHNIDKLQVIKADTEEVDRQWEGLSKTISTLIGGINPDSGQILFQQLEKEKARWCEMKEKVKETLERTQSLQKVWQRYSDVKCICSEQLQHHREQLSTHTKTPADHKQLAHSIAELKTVLQKGSEMLQTDVNEMLEAS--KDVIE-QMNEEDAVFIRSECRLITRGYLQLKQTLTGRIEHMQEDLEQFQEFERLFQSLETQLQRWES-----KQRMDSEHTDISQSGLMEISSLSPDLDLLNTLSYRLTLSDPMTQKLQNLNRKWAQASAHAQEKCSELQAASLQQQSFEQRCESWLAFLQRMEDSLAVEIASNYTGLREQQRTHQCFQAELCLGHQILHSVISESLLLLQKGDVEDRSDFLLKLAQLREHWQGAVQRAAQRRALVEGLIQHWHLYRHTMQKLRKLLTLSHTLLSPAG-PTHCSVLQLRLMLDDLKRTELLFQRSVSAYLCVMEVGRQLFSVSDLQTQTQMQTDLAALQEDWEQCQCMVGKRKTLTSDIIKKWETCETRLADQTQHLEELQSRLKQSIPDQQEEMEEERLLVKEVQDCLEDWAVSLSELSTMKTDLSQYILTDDVLLLQEQVEHLHCQWEELCLKVSMRKQEIADRLNAWIIFNEKNRELCEWLTQMENKVAHS-AELSIEEMVEKLKKDCMEEINLFSENKTHLKQLGEQLITASNKAKETEINDKIKDINDRWQHLFDHIEARVRKLKETLVTVQQLDKNMSNLRTWLSRVESELAKPVIYSICHNEEIQRKLAEHQDLQRDIEQHTEGVASVLTLCDVLLHDADACGSDGENDSIQQTTLSLDRRWRNICAMSMERRMRIEETWRLWCKFLDDYARFEEWLNTAERTAANPATKDVLYTCAKEELKKFEAFQRQVHERLTQLELVNKQYRRLARENRTDGASKLKLMVHEGNQRWDTLQKRVAAVLRRLKHFTSQREDFEGTREGILVWLTEMDLQLTNVEHFSESDIHEKMRQLNAFQQEITLNTNKIDALIVFGENLIQKSAPLDAVLIEDELEELHSYCQEVFGRVARFHHRLISRRPVLEEEREFSDRDTDPEDSADFGGVWEREREEEEAAMGCDVSLTVRQAVSQLLPP--ALERSGRETPVSVDSIPLEWDHTVDVGGSSSPEEDEE-LTYYSALSDVEVTESSQS-YVKATAKALKAVSGGRSMVETWHSPDAPDRKRANREIILSLTSSPIDTSAQYHPQAYDKLMSECAGSIDSIKRVKLILNEDEQLEDQGLTGFSAADNTDGLCSGVIERWELLQVQSSR-VPQDLQHWHRLNSDLSDIMVWLNAVMPELETLQTLEAKITIRDMESKIHKLKDMQRTFNGYKSVMIGVNLSGRSFQHGDSAELQELRETLQRVNQKWTQACAALDSWEHRLHRALMECQEFHETLHSLLLWLAKAESQRYMVNIHDQNTDLNILQEHQDTLKAVHQELQSREQEVNSLQDISSQILLQDQGEDTLEAKEKVHVISNKLRLLIRQISHDLNTLHSRLDSSGPNVDRTASTQQQE-----------------ASGAQAVTQGSPASVRCEKRESSPARPFLYRVLRAAFPLHLLLLLLLVVACLVPLSEDDYSCTLSNNFARSFYPMLLYTNGPPPT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TCB4-1", "uniprot_id": "A0AB32TCB4_DANRE", "id": "A0AB32TCB4-1", "name": "", "aln": "MASGEESSAPPEDERGVLLDIDDVHLLLQVEQEQIQKRTFTNWINAQLSKRSPPAAVQDLFSDLRDGTRLLDLLEVMSGQRMKRERGHGVFQQRGNIETALSFLKNKSVKLVNINIPDILEGKPSIILGLIWTIILHCHIKELASTLSFGSRSSSLDSLSSLDSFSGSPAS--SPVPRGASPLHTRFRLSAKKALLLWVRDQCQKVGCPASVRDFKSSWRSGEVFLAILCSLRPDLVDLSQFQTSSNQQNLEKAFYLAEKELGIPRLLEPEDVDVSNPDEKSIMTYIAQFLQYSNDLPLSDDDIELQTLLFPTCFSPVN-------------------------LPTHFTPAVLASPLHQASPSQKAREMKCWLQRAYQELLDSWISTEGKGYAERYQAFQNFVGTYYEQRRPVIPVLSAMKRSTKPNEEQMELRKAWDAMEERLQEYKSELDVGLPAPLNTLGQWLQHIEAVLTEDSSNTEDHALAARDARHKQEQLKVLVEDLSQHLNTLHHYCNADDDNCPQVPVEKLEEIKRRFTSARVTAKYHGIKLQYREQMHHVYDLLGRLKSKLSLWKGPYGSQESVQSLLQDWHETVDKEGLVWKLKEALHKLKDTTISYASKAALADDLPVVNRQVKEADSETRAITDAAESVKSTMERVLGAWESYKDYLYRLQVWLGQESQTQMQEKEQKRFSSSENEWSTRQAQLNEAGNFLIEMSDTSTSHSLSDELRRLNMQWADFIKRTKFAVTHQPICTVPGVQTAQGLMQESGCVLRDTLEVSSGPLRIYRKKLQGIIKKISELDLNSIYPSPDCKEETLHKLKQALLEMYNTLNRVDQVCEGLQR--AASLLEGRLAELENWSTEAQEVCQHLSSRQRRGHLEPHLRAKALISRGLQLEGQVVTEGEDLQVLVTSLQKNFTLPYLSITDLQDRLKQTVSLCQEVTEMLSCHGVKREGQPESARPASKVFVHTLSQPEFQTGSIQHYQMFSRSSKLSLDSPVESQKQDFHSFQLQTPFEATGGAKHQALSQFHDKSPEDQRKAKCQIQQADLKQPLLSSVVGRKVQMKPQTKVHLISVDSSQTSCPGSSGPFQVISVESNQSSSIEPSVPLPVVSVDSSHTRGFRPSEVQVVSVNTSQTISFGHSDTLHSIPIESKQTSGFGASSPLQEISVHSSQASSFRQSEPHVFSVNSSQMSGFPPSNRLWVSSVGSNQTTGLQSSDPLQVMSVESSQSSNIGSSEHLHVTSVESQQCSEPSDPLQVVSVDLSQTSGFRQSEVQVVHVNTSPTIGFGLSDPLQIIPVESNQMGGFGPMDLQVVSTDSRQSTEPSVSSSTMSSTSTLIKSDTMTPLRMPIEQHLASPPTRQVQTLLAPS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQRQTVLVKSCSFTQPHDEQSQTQSASCQSTLGEAVTVTRLRTPIKHFFDSPPKLQSQTSVTTLHPKQRVLARSHSFPQQVQASGVPHIPVQNEVFARAQALARSRLEKAKNHLDEHIQDVITVIRTRDKSKKQGKKRQAISRFLRPTVLETFLEALKGMGDFCSDAQLRDMDLLSQSVRTQWEVCATAADCSVHLEALRRIKESLESAESVLLSTTHQRTDTQRVEDIQHLTVSSSDLAPCQNSRE--DSVPLRETVLLEDLSLVHSQAVVQTNIVEIKQIAERTIIHPCLAQEEKATVEKAQSRYRDAQSVLHQQLLHNSQQLESDFPISPGSSITSISSDSLRSELQHLLALKDQTEALWCDFEIQFSQSSQHMEDGCNMEQERHQLIQQWREQQICVQARVKSIETTIELLESVDIQIALISDQLKQISQKP--LNVRNFAVVDARNLHEELKCVDESIKKELFLLNERESLVGDGTDLSHIELQTHLPLQQTLHNRTKCLEQQRHCVQKSESALVALEKLLSHLQQLNDELNAHRTSDQS---------YSSVSFQKSLEQVREDSLQLDTMLDDAGLRITLDDKAGSCVEMVSALEEGFQVRLVEGQRVSDGGRKGREKQEKKEERAFGRKRMGLLVTLREVLAALERHVLKEPTLPALQHRLRFLTDMESKLHALRSEIDDLRDANTSDTN------------LSELQTQWETAHRSVTESREQCASLTELLKKFQSCRNNLGGTLQRAEQTIGDQASYMGKDNLQLLISKVISIKSDLSGLGDGVEEFRSVCRQLQSLVRRVLDCTDAPFESEADTLMDRWLDVTEKTDCYLDNLQAGFSLWEKLLLLAEEVEGWSAQKLMTLAQSNPFQTEVDVSALQNELKVQEENINHFHRRSSEIQELLQSQEFPLELQVIESQLRKKVAEVKELFFETKDVFRQLETAKMQVASEIADHLSSLQTITDNLNALNTSESTHALNSIQRLSEQLEVKAEQADALLQQMDLLASIAGLENLQTLSEAGAHLQESIRIAKELNIKKGEQTMNPNKPVTSQPVEESKHTEAHIEKVEDTTELQTVWDDKADEQSQRSKAKDAALEQKYFKEDILLSEDENWRVTPKERLTYAQSLSEPEVREDDSKMTSPCGSPKPIFTIVLDSDLSKSTQNLPAQTTSACSTQWHTVSVVHDRTTEKADESLTLEAKPSVSVAEEHAVLSTSDESLYSLYANLSTSGPLNENNPTDDSEPTCSVSDQDFKPKTEKGSSTKSLEQKISHTSIYHGSSKTAKKVFTIILDADSPELSLVQSQSLSQMQRSGTEFSRTDEFSHSN-----------------------------VKNQQRSSSRTEKALRKVAEKDNVKSSSSKTQEALQHNISEIMKTDIEKNEKEKQYEVMDVHKGGDSELGFLVHEQDVTMSESRDKAKKIPSAVPLNKAKTLQKPQNVAKGRKKIKKSGDAKKSDGFSGTKLKTSESEYKMTADSESRQTSEITVLATRDTSLNVSSTCSQSKSTEAKLTEAVDTKTLNLHTEAKQRHFGTVGVVKCASIEATEMSLGTGDIVQSKLTEKSMATEASPVMRAECITQIPAAIVDVNSTTLLSDSHQSLLQTQHTGLKDSKTKEFAYKDAKTQQRSSAGTVEPEEQEPERLLSKKYNVKSLSSVLQEALQPNTSEIMETDIEKRDKEKQHKVTDAETSSQIGACAEDNESGIKTLKQDVTMSDKHTFAEPSNDANALQKPPNVAKGRKKIKKSVDAVKKDNISSLKLKASTSEHKT---KAELESLQTSEMKVPDTTDTSLNVASTCSQSKRTEDKHTEAVGTVQEDGLNLLQTEAKHGLFGTVAVSVVGGAPIEATDIGLETADIVQSKHTEKSMAADALPVMRAEGITQIPAVVVNVKSPTFSHQPLLQTQCTDYKDTRADVFAHKDTKTQQRSSAGTEKPEEQEHERFLLEKDIVKPSRSEILEALQINTSEIMETDIEKEKQHEVIDTDTLSQMCACAEDNESGIKTLKQNVTMSDKDTFAEPSNEANTLQNPPNVGKVKKKIKKSACAEKSDNISSIETQHKVTDTETSCQMN-----------------------------------------------------------------------------------------TRAEDNESGIKALKQGVTMSDKHTSAESSNEANALQNPPNGGEDTKKIIRLADIEKSDKISRRKIKASRSKHKNTDDSDSITFSEVTVPVTTDTLLNVSSTCSQSKSTENNLTHTVQETLTAKDGQFKTVSISHCRGAPTEGTDSLVSGAVETAQSTHCEKSTATDVSSVVRIETKTQISNLILDVDSPEISSHTQCEAPESPRSDEFALTDFRIQQRSSSGTEKHKKQEPEQNLLEKDYLKSSFSVIQKALQPNISEITETIVYDNEKDEQHEDISSEISSQISVLMVEGSKCGFVVHKQDKTMSESHGEADKITFAEPSSEANTLQKLTNIAKGRKKISKSALAEKSNKTTNRNQKTSRSEHNSTADSESLQTSEIILPDTTDTSLNVSSTCSQSKTTKSVSSEDKLSETVDTETLNLLQTEAKLGQFGTVGVVECAPIEATESVVLKTEDSVQSKHAEKSMPTDASQVMRAEHITQIPAVIVDVDSPPLLLSGSHQSLLQAQCTDSKGSREDINAYKDAKTQQRSSAGTEKPEEQEPKGLLLEKYNVKSSCLVIHEAFHPNTSEIMETDIEKCEKVKQHVVTDAETSSHMDARAEDNRSGIKTLQQGVTMSEKQTSGEPSNEANAHQKSPNVAKCRKKIKKSADAEKSDSTSSVKLTSQHKRTADSESLQTSEIIVPDTTDISLNVFSRCSQLKTTESLRSENKLTKAGNTVQEETLNLLHTEAKDGHFATDMDSETADIVESKLTEKSMPAVASPVMRAERITQIPAVIVDVDSPTLLSDSLQSQLQTQCTDTEGSRADVFSHTDVKTQQRSSAGTEKPEEQEPEGLLSEKDNVKSLSFVMQEALQPNTSEIRKTDIEKVKHVVTDAETSSHIDARAEDNRLGIKTLKQEITISEIQTSAEPSNEANVHQKTQNDGKGRKKIRKSADAEKSDNISTIKLVSRSENKSTTDSKSLQTSEIILPVTTDTSLNVSSTCSQSRTTKSVISEEKLTEALNTVQEETLHLLQTEARDGYFGAVGVSVVGGAHVEATDSVVLGTRDIVQSKHTEKSAPTEASPVLRAECITQIPAVIVDVDSPTLLSESYQSLLHTQCTGPKSSKTEEFSYTDVRNQWRSSAGTEGPEKQKPERLLSENDNVNSSCSEIKEALHPKTSEIRETGIEKSEKEKHHEVTDAERSSHMDTCSEDNESGIKTLKQDVTMSEKYTSREPSNEANTLQNPQNVAEGRKKIKKLADAEKSDNISTIKLTSRSEHKSTADLESLHTFEFMVPEATDTSLN-----------------------------VSSTCSQSKSTEDKLTEAVDTVQEETVNLLQTEVKHEHVETISFCAVGAVGDMQSTFTEDSGSMLTDAPPVVRAECITQTPTVIPSDLQLSHAEAQKTGDSDGSSLSQSEEMQRTNANPSARNKSTQNKGSEEDGEDQTRPLEQPAGTNIWTTLINATTTVQPLLMSSQCSEESWPKANSSFQNALLSEPDSSLAWTVLHVYRCQYRPAQLNIAHMTHQLEEAETCRQCVMEQVARLSHNECSVGHPTDSEKG----------MDARWSAVLLATSTMAELKKAQLQHITQYHQQKQALMITLDKLEAELSTLTLGCIESSTLQAEKLNAFLKNMQKNRGMLEDLLQTCSQISAHLGEAEGHVACIEPVRTCQERWQTLEQTAFRSLWCANICTTEASALLQESRELQFEMELLVKSVSSGHLSQGQIDWQNAIRDTMRAADLAVLTERCLYLHEVSQALFSSPLGKKEIRDVEDTIQALNSQLELTKEKIG--CQTPNSSDHSAVVRIIRDYVTWAKQMESRISRR-RRMSLFPEEASHQVNHMKKLQSETSLKRFQLASVLKEIREEVTELDEEESKAMLSTFDSLEELYNNTAKKTESALEEMNRTLLIRDRLWKQITDSSSWLTSVLEKESGKSVASEPKTTIPELRVQLQVCTEALKDAERQENNLETLLDDSKTMNNGLSLHESFQLIDRLAALQEEVSRVVNRRFASRWVIEELLHSQESSAEEQNVIQKSLR-----------QIGADIMRQKYPVTRDSLLALESVKHMLMELLCKVPEVPH-----CPEPRRKEMLNAIVDLQRKIHLLELQAKEHEEYLTLKQQLENSREVMKKSLSQIVDS-SLRDDVRVGFCQDVLAKLPLVRMACQETADKIEAISKDLYPSQLTAERQKIRLVVEQLASWEVTFKQEAKILECSVAERFGSPTDLSPPIQLFNSVRQRLKKTICLRPDKKTIDAELQNHWMVIQTIESVLRMLESSRKGK--ENESYKTTIDLGKKTLRDCSIYMDKLLQAQEALKHYHWAVQG-------AESFLQQIKSSLMISSTGFKNDREELRYIQQIFSSLAEGFQARLSEIGACVPQQTCLSIPLTEQLHIEVLSCFLVQDAKLEAQAQFQLEALQRRMRDQTVHLSHHEEMSQLLKNADSQISKCFSHKPTDPESCQVHQLKVKVLQTELKKLAESLEELREHCPGSRCSAPVDLMLG------HLWRCWAVMKNRVEALKASTSHKEAEWRDFMIRLNKSKEGLHRLQTDLPDSSPLT--GSLVDLQGFLSLTDHLQDGIEQEHQTLASLQHHVTRLLGVTNLQQLKESPQICQDLQSLLGHCRSLRDQSNSIRRELLFEMQEFGRVQEEMSSIQQNILSLLTVLQSES------AAEHLQEVKVELVSQKARLQDVMERVMKRWR----SVPSEIHILQNELNASLQEAKDKLAMVMEKSGPLRKMGEQIGEVTVGLLCVQGLLKQTSPNFSEAERTQKRIWDELDQWHTRIAELEGEVQDLAEQQPERAHILMDQLTQPLQLYQTTAKQAEHRTALISKIPACLQDYEALLSSTNCWLKEAEPWLLTPRTYTTAKCIHGHANSLKMMLDESEGYRAALETFMPSLQEISPVFDISPQKQLLHLGMQNITLMQQSVLEPLSHLQHLAAEMDAIEAEVKTMEKNVTKIRTILSASDTQNISPEEHLENIQVILDNVQSMKRTIDEIESCRPGLGLPAGAEQTLTVFSRSQELLQPIQELQQLSVQHSAALTASIG--------------------------------------QPAELILPSDQPSEVPMPQLYSEDVKQMSVDGLYTEEEDEDSRSSSSGTLTCSVPEDPDETMVDEDIKSESAPALTEYDFKEPTTEIKKDFVTIEHESQDTEYCLLESSESSEKDSKPETEETNCLSALTSQHLQEFTNNNSLKPDATKIAEKN-------------------------------------------------------LNEYTETEMPDTESAKPGKDSGTKMPDTESAKPGKDSGTKMPDTESSKPGINLETEMSDTES------------------------------------------------------------------------------------------------------------------------------------------------AKPGIDSKITKLQSEEDLQKMSESGDEKEEPMN----------------------------------------GEMSTRNSIKTTVHNEGLISKTLDTDPINVTDGDQTQTEAKPPDANASLGITESVSQEDAMLDLQIDVNETAVYQSSTPSQEHTLHQTTAVSKSEDQESLVQLLSSLKETSQDISS-------------------------------------SETRQHPLDVPVSLLNATQTQDATKLLKDFSSTKNVQGGTWMLVIDQKKTAGQNTEEIQR------------------------------------------------------CCEALLKGLQGLLDLGSDRLLRSQDEVPHNYSQLHNLLAGHKKYFQDMQQNLVMVKLLFQKLPEGAVQG----QAEVEDLISDLLHRAQRQGIQMQQSSEKWSQYEEVSHRLHSRLDELETDMS--SLNVEPKGDLQGQLRSYEKLHKILEDTCSQVWETEDCLRSLQKQGYCCER----KFQTVSKSPLLMHWKHLHNQLQQKIQSTQKIRMNYERFQRDSTELEEWMRCAHEQLQKWKSFSGS---DTPESRMAFTQLMEFFKDLEVRSAQKVSAESTGTQILQLTNSEAP-----------------------------------------------------------------------------------------------------------DLRTRLANLQEEWTKLTSVLPALQQTQQELLEGQSDSQ-ILADLSSWLQHIERRLEDESSGVHCALDSSELSRHLQALKHVKAEITNQQPCVNFLNHRCMKGAESMNESTNRSERILLAEQLGAFNLRWLLLQAKIGCVIHDVEDQWQACGDREKLLRCIHSWISQHMEWVKNSWRPGSCSQIEQTLQECEGTEKRLQVKSIELKGLEALHLFKQQDREHPGDQAFSRQLNSAIEDCQTLSQQINALRSDLQPIKDEWVRVESKMSAAELQTTGVIYRLELCRVPVFSSEQSRSHVEQIQELKRELNQPD-IWTCSTEVLSNLKEKIKPFAFKLLSDRLEKERIRRHTVTEDVCEDLLKAQNALQLWLGYEHLTEECRVLLNQHWERLGELMNSSDREENTVEMLISRMQYISALEKDLTTLQSNVGKVMEASKLLIGQMQPQSAPLIKSETRLLSRDHVHLGRVLSEIRIQVQEELEEQRHFSTELKSIEKQVKNFESIMSSSTTSMER-----LKMVLLDLSGLNPNLAALNQRSLRCSLSSAEEERLQTLNTQWGQVFSQATERHRKMYGELLRDQNFQQKCQCWMELLDKMETDLANPTPGNCSSVRDLLAAHQRLKVEFLIGQPLQDAIINEALHFLESSQNEDRSSLLLRLTQLKTRWQETQQRLHQHETRLEELMGQWQLYEAGTRKLSRLFRHMEELLSPAG-LAPCSLQQLQHSIKDFEWTEEQLQLHEGLYRQTVKAGGQIIPIVDTQMQKSLKTQLDALKDTWEPNSDLVQKRKALAYTITQNWKLCVTGLVDSALKLDEIKARLKSPLPEKIEDLKKHEQLTKEDEDLLQIWIVGLKELSTMKADVSQYVLPTDTALLQGQVEELHCQWEELCLKVSLRKQEIADRLNAWIIFNDKNKELCDWLTQMEKKVAHRGENLSIEEMVEKLKKDCMEEINLFSENKSHLKQLGEQLLLASDKAKETEIHGALRDVNDRWQQLFDHIEGRGKKLTETLVTVQQLDKNMNNLRSWLTRIEAELSKPVHYSICHREEIQKRLAEQQDLQRDIEQHTERVASVLTLCDVLLHDEDACSSDGENDSIQQTTQRLDQRWRNICSMSLERRLRIEETWRLWCKFQEDYSCFEDWLNAAERTAAEPNSSDVSYTDAKEELHKYEVFQMRVHESLTQLEIINNQYRRLAWENRTDAASRLRAMVHQGNQRWDALQRRVAAILRRLRHFTGQREEFEGTRESLLVWLTEIELQLTDMEHFSESHHQDRMKQLKSFKKEITLNTNKIDALIVFGEGLIQRSAPLDAVVIEDELEELHTYCQEVFGRVARFHQRLTSLRPLQEHPDVYDGE---------------RSRETQSPPS------SSQPSMCLLSPP---QERSGRETPVSVDSIPLEWDHTGDVGGSSSHDEEEEDAAFFSALS-----------------------------GQNWHFQNMPERKSFQLESS------SPTHTSTPFKQGYVQLMSECSGSIKSVKRVSMILDDEEQQEEQGLTGLNTADKQ----SGVIERWELLQAQAVSKEQCRTRDPQQLTSDLHDITSWLDCITLELDMLQRPETSASVEVLEERVKQLKEMQKTFARYKTMMLSLNLCGRELQQEASGGAPELQEGLHSMNQRWTEACAGLERWEDSLRNTLVRCQEFHEMVHSLLLWLAHAESRRYAVNMNDASVQLSTLQEHTQTLKDLAVDLQGRQKQVNSLQDIASELLPEAGGEDSTEAKEKLHVIGSKLRLLSRQVEQDLQTIQERLG----------------------------------STTDASGDQKSPECSRWNGEPSPQRSFFYRVLRAAFPLHLLFLLLLVLACLVPLSEDDYSCTLSNNFARSFHPMLRYTNGPPPT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : .***:*: **.***: **::** ***:**::::.* .: *** :::.* *******:***:: *:: ..** * *** **:**:::*:**:**::.**::*:*******:****:* **::**.:** . ...* : :: : . .... . ::*:: **:**** *.::** . .* *** ***.* .***:: :***:::*: : :*::**.:** :**:** **:**:* **** :*********:****:**:* . ... *.:: ** :.: . .: .. * :.*: : .*: : *::... :*: : . :. **..* : .:: :: :*: **.**. ** :* :: . . .:: * : * :* : : * . : : . : . ** *:**:.**:. .: * . *::: * *:.. : ** *: * *:*:* *::**:: :. : *. :::: . * : :..: :. . .:.*: :.* .* :: : ::. : : : : . :*. . : **:...:*: ::. .. ::*.** *:* * .: . : : : * .. : :: * . : : : . :: * . :: : :: * :::.: . : **::* : :. : ** . .. .: : : :* ::: : . * * . . . :.: : . . : . . * . : :: . * :: . :. . .::: : : :: : : . :. :. : :: : .. *: :. : : : : : . . . : . .** : *. :* .. : .*.. . :. *: .* .* : :*:: * .:* : . : : : : :: :.: ::* : : : . * : : : ..:: : :** .:: . : .:. : : : : :: .: *. : : **: :* *: : . : :::.: ** * . : : . :: . . :.:: .. : : ::.: .: **:** **::** : * :: *. . * :: . .. .: ** . *:: *** ***:::*. :. * :*: * . *******:**: ::: :*.::. ::::..:*::** :.:: :.***.**: ::* ***:.***: * :** .: **:* : :: *: : :* : :::*:: *:: .* *: :** ****.* ******:*:.: .*: .:: . .: . .: ..: . :.: . :: :...: . . :: : :*: : .. * :::. ::. . .*: . . : * : :. . :: :. : . . .* : .: * ..:* . : :: . : * : : .: . . . .* . : . . * . : : : : ...: * .. . : . : * : .. . . :: : : . : . . : : : : : . . .* : :. . .: . . :* * . . . :*: *. : *. . * . : . : ::: : *: . * : : . . .. . :. : : . :: *: . : :: : .: . : *: :: *:. . : .. : : .* . . . . .. :. : . ..:: :. : : * : . .: : :: : *: : :: * :. . *: * : :. ::. :: . :. . .* ::: *: .::::: * .* :* : : : : . : *. :*: * *::. :. : : ::* :: :: . ::: ::: :. :: * : . : . : : : *.*: : :.*:*:: *:.. * :. .: : : :*: * : . : : .*.. : * . .::: * :..: * . : . : .:* : : : .. .: * . . . .: * * .:* *: . : . . .. : :: . * . :.. :* * .:. :: . : : :: ::. :: *: : .: : .::. :: . . : .* : :: : * :: : * * ::: * ..:: *. . . :.::. ...*::. :. : *: : . . . : : : :. : . : . *:. . * : . . . * : . . : :: ::.: :. :: . . : . : :: * :* :. . . *:: : . : :.:. . ... : : *.* :: . .* :**: . : :* : . . . . : ** . ::: :. :. :**: . . . :* :* : : :: :: : * : : .:. : ::: :: : * . . : : *:: . ::: ::. : . : : ::::*:: * . * :: : * : : :* *: :* :*:: .::: : **.* : :* .:. ** :: *:*.* *: :*. **::***** *: : :: *:**. * .* .:: :*:* . * : :::** **: :.* ::::. ::..:: *:.::. * .* * : : : :..:::* *::* : *. : * ::. :*: . : : .:: :*:.:: .*.: :: * :: ***:*** *** *:**:: * :.: . . :. :.: **:** ** . : * ** . ..* **.*:. * : : *:::: : . : : . : : . : . . : . :: .: . . * . * .. * : .: : : * . : * .: . : . : : *. * . ::. : .. : : . : . : *: .: : .* : : :. :::: :. : : :.* * .* : . . . : :. . : : : . .. : : * : . . *::. :*:.: *:.:*. :* . *: : *. :**.: .: :: : . :* : : ..: * ::. : ..::: *.. *: * : :. .* :.: * *::: : . ::: . : : . . : . : * : *:::::: :. : :. ** * .*:. ::. *: *:. : : .: :* *::: :*: * :. * *. :* *.: : *: *::.::.*. : : :* :*: : . .. :::: .*: * : :.: * :.: *: : .: *: :* *:*:*: :: :.* :: :** ** :* :* ::. :. *: *: . : :: :: :: *:. : : :: :* * :: * : : ::* * : :. :. : . :. : * * :: : . * : . . : * . :* .: : * . :::::: :: : :. : * :.:. * * :: :: :. : * :.. : : * .:: ::* . . *.:: :: : .: .. : :. : . . . : . : * .: : . : * : * ..: * : :.* : : : . *. . :: ::. .*:: ** * : .**. : **.:* :* :. : * :: :: . *. :.* *: *: .*:::: * . . . : : ::: ::.*. .: : .: : ::* :*:. : *.*..:: .:::* :** : : *:. : *: :*: : ..* ::: ***.. *: * : :.::: .* .* .::.* :: . : : : *:: *: . : : :.*. * . : :*: :::: ..:*: * :.:.. * ** : * * .*.**.***:*:::::* * :*: *:: ** ***:***:*::***** ****:*::**:**:*** **.***:** : ::*****:***:*******.**:*** :*:*:*:**: **.*:: :*:. : .:*****:*** * .* :**.**:. :*******.***:**:*:*:**:*** *.:*. :***::***:**********: * **:.:******* ***..: * ******* **:******:**:***::******** ** :**: **:**::****** * :.:* ** *****:::*.** ::** *****::*:****** ***** **:*: ***:****** **:**:*:****::**.***:******.:******::****::******. .::*:**:.*::********** ****** ***:* *****:********* *********:***:** * * :. . . *.* .. . ::. * .* **** **************** ******* :::** .::**** . ** : *. : : . . . .. *. . * : *: :. : .*.::***::*.* : ::*.**: * ** **: *: :. :. : ::::*::: ::* **::::.:*:. :. * **:. *: :. * . . :: *. *:.:*:.**:**: :.****** *:.:* .:: . ..: * * * : :* *: :*. *::*:..:* : *** **:**:*** .**: * .*: :** ::: . . . * *.*: **:***:**:**:****::***:* **:***** :*******:*** ********", "identical_positions": 1086, "similar_positions": 1967, "identity": "10.75%" }, { "cls_id": "homologset.agr.HGNC:17085", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A6H5Z3-1", "uniprot_id": "EXC6B_MOUSE", "id": "A6H5Z3-1", "name": "Exocyst complex component 6B", "aln": "-------------------------------MERAKMAE-ESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQG---FVDSITELLKVRGEAQK-LKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLP--QVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLES-IRKHSDKIGETAMKQAQ-------QQRNLDNIVLQQPRIGSKRKSKKDVYTIFDAEVESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFS-------PVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNR---AYIDELWEMALSKTIAALR-THSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPFQD-------IELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTE-VDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLDNKASDYLVDLIAFLRSTFAVFTHLPG----------KVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFAR-------------------SGPVPGFQED--------------TLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEK----MKDTS----RKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0M2U2-1", "uniprot_id": "A0ABK0M2U2_RAT", "id": "A0ABK0M2U2-1", "name": "Exocyst complex component", "aln": "-------------------------------MERVKMAE-ESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQG---FVDSITELLKVRGEAQK-LKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLP--QVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLES-IRKHSDKIGETAMKQAQ-------QQRNLDNIVLQQPRLGSKRKSKKDVYTIFDTEVESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFS-------PVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNR---AYIDELWEMALSKTIAALR-THSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPFQD-------TELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTE-VDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGELDNKASDYLVDLIAFLRSTFAVFTHLPG----------KVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFAR-------------------SGPVPGFQED--------------TLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKISREMKDTS----RKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y2D4-1", "uniprot_id": "EXC6B_HUMAN", "id": "Q9Y2D4-1", "name": "Exocyst complex component 6B", "aln": "-------------------------------MERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQG---FVDSITELLKVRGEAQK-LKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLP--QVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLES-IRKHSDKIGETAMKQAQ-------QQRNLDNIVLQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFS-------PVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNR---AYIDELWEMALSKTIAALR-THSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVVGQFPFQD-------IELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTE-VDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPG----------KVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFAR-------------------SGPVPGFQED--------------TLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEK----MKDTS----RKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G0F1-1", "uniprot_id": "A0AC58G0F1_DANRE", "id": "A0AC58G0F1-1", "name": "Exocyst complex component", "aln": "------------------------------------MAS---AEIAAEHERILREIESTDTNCIGPTLRSVYDGQEHGLFMEKLEGRIRNHDREIEKMCNHHFQG---FVDSITELLKVRGEAQK-LKGQVTETNQKLQNDGKELLTSMNELRQCRVQQRNIATTIDKLTHCLPVLEMYSKLQEQMRAKRYYPALRTLEQLEESCLP--QAGSYRFCTIMAENIPRLRTHIRDVSMSDLKDFLES-IRKHSDKIGETAMKQAQ-------VQIARDNAVTSQQRSASGRRIRKEGYGSTEVDRTGNNPFSEQDSGILDVDDEQE-EEVPGAHDLVDFS-------PVYRCLHIYTVLGARDTFENYYRKQRRKQARLVLQPHSNMHETLEGYRRYFNQIVGFFVVEDHILHTTQGLVNR---AYVEELWELALSKTIAALR-THSSYCTDPDLVLDLKNLIVLFADTLQGYGFPVNQLFDMLLEMRDQYGEILLKKWSQSFRQILDQDNYSPIPVVSPEEYQRITGQFPFQD-------PELDKMPFPKKLPFSEFVPKVYSQLKEFIYACLKYSEDLHLSSTE-IDDMIRKSTNLLLTRTLSHCLQYAIKKKNVGLAELVQIIINTTHLEQSCHYLEEFISNITNVPPDTINATKLYGTSTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWTAAQGGGQASDYLSDLIAFLCSTFAVFTHLPGNAIEHATLPGKVAQTACMSACKHLSTSLLQLLLEADVRQVSMGALQQFNVDVKECERFAR-------------------AGPVPGFQGD--------------TLLLAFIDLRQLLDLFTQWDWSTYLADYGRPTCKYLRVNPHTALALLEK----MKDTS----RKNNMFAQFRKNERDKQKLIDTVVKQLRNLIASNQA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VDE6-1", "uniprot_id": "EXOC6_DROME", "id": "Q9VDE6-1", "name": "Exocyst complex component 6", "aln": "-----------------------------------------------MSKVTVQDIEAVD-DYWGPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLYYQG---FIDSIQELLQVRTQAQQ-LHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAKNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLEN-IRKFSPRIGELAITHTK-------QLQKRD---------------------INAIIAEHMQQMNGGEAGGAGAGGDDDGANVS-AQDLIDFS-------PIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGFFVVEDHVKNTAGDVVTS---SYLEDLWSSSLTKFVNEIS-MSSSSCTDPNILLRIKNLIMLSINTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHS-------EQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNE-VAAMVRKAANLLLTRSFSGCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTP----SAMFHVARQDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLP----------HIAQAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAA-------------------SEPVPGLKEG--------------ELSKYFLRNRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEK----IREAD----KKP-IFSLVRKN--DKKKLLETVLKQLKHIADRQN-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P22224-1", "uniprot_id": "SEC15_YEAST", "id": "P22224-1", "name": "Exocyst complex component SEC15", "aln": "MDQEGQPLLSKDFQQVLLATASGNNSSWTERAVLNNESTDAVKHEPALGQNDVFDLDPLSFDKWVPFLRRALDKNQLDPVIDELENSIEDNFQGLELQLLQDSQMNDKLETSIDEIANIQGMVQDTLSSEISKFQIRLSESANELIVKKQMYVNNKKISLKISEATILITKVVRILELSSKCQELITERKFFKVLQNLDSLEKLYLQEFKNYNFQFLIEIYNSIPFLQKVTKDECINLIRNSLNLNLGKNLIKVGQEFVAIYENELLPQWLETRSKMKLTNFKFNSPIEISMRDESFLAKLNLGEFFQLDDFHDSIMIFQNLNELSVLSGEFNKEYELRKTKLMYPLIWKKNKTAAYQMDSLLRGTGTTPGSTAHDVSTDDPFTQSLSLHFLQDYFLKILGFLLYDINLNKATEFILVDNNYNSTNEFWDGLMDRLSPYLSYFIDEKLKTEEDMIKLKDFLCIYVAILENFKLNIEPLYKILVSIFEKFCSVSLRAFDDEFQILLNDDDFMPLSINDKTLYEKVLKICWMKEGEHLSLPDPTNGEPFAVTLPFSPLYPMTCTLAKKTYSKITAFLSIFYRHELHTLNNILVKTMDDIFNDIVNKKIRSKLESTSR--EEIAQILVNLDYFIIAAKEFSNFMTREN-ILQNPDMEIRLSSIKYLAESRKLAETKLIELIDSKISDILETIEIDWQITEVRQDPDISIIDLAQFLEMMFASTLQNLP---------YSVQTLLIFREFDSLTRQFMGLLLHDTPSTITHESIMNFEVDVNYLESIIPRIFPSTPGTIDSNGYQSPMTPSTPTFPNANGVDAPTLFENNIKSLEATFMELKQCIELLKTQGKDYNEPEIRLR--KYSRIRQEDAALLLSKIQHFVSSVEGANGDDTSVMDSSSIFNSESASVIDSNTSRIAKFFNRR--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : :::. . * :* : :: . ::** *..: : :* * : ** *: ::: .*. * .:: . : * . . .*: : . : . ::: : : : ** * : ::.: .*:.*: ** * : ::* : .** :: : . . ::: *: : * ::*: : : . . . . . :: :. : *: : . . :. : : . .*. : *: *:**:: : :: ::: :: :::*. : : : .. . : :: :*::: : :: : :: *:.:* .: ::: . *: : *: :*:.::: *: : . *: : ::. : **. .:*** : * . *: : . : . : :: *: : ::. .. : :. . :: **::: :: : :.:*: . . . : :*: ** :: : .**.:::: ** : .. : *: :* * : . :: .: :: . :: :: ::::*: * : : ..* : * *: :* ::*: . : :* :. :*.* : ... . :: :. .:::: .:: : . ", "identical_positions": 74, "similar_positions": 269, "identity": "7.99%" }, { "cls_id": "homologset.agr.HGNC:17086", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0L6W5-1", "uniprot_id": "A0ABK0L6W5_RAT", "id": "A0ABK0L6W5-1", "name": "", "aln": "MSSLAVRDPAMDRS--LRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDS---PYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSH---QEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQPVSGPGPGGPGGPGGPGGPGPGPAPGLCPGPNVMLNQQNP-APQPQHLPRRPVKDIPPLMQTSIQGGIPAPGP-IPAAVPGPGPGS-LTPGGTMQPQVGMPVVGPVPLERGQMQISDPRPPMPRGPMPSGGIPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYMGPPHQGPPMHHG--HDNRGPASHDMRGGPLAADPRMLIGEPRGPMMDQRGLPMDGRGGRDSRGMEARPMETEVLEPRGMERR-METCAMETRGMEARGIDARGLEMRGPGPSSRGPMTGGIQGPGPINMGAGGP-QGPRQVPNIAGVGNPGGAMQGAGIQGAGMQGAGMQGGGMQGAGMQGGGMQGAGMQG--------GGMQGAGMQGASKQGAGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C7E9-1", "uniprot_id": "CSTFT_MOUSE", "id": "Q8C7E9-1", "name": "Cleavage stimulation factor subunit 2 tau variant", "aln": "MSSLAVRDPAMDRS--LRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDS---PYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSH---QEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQPVSGPGPGGPG-PSGPGGPGPGPAPGLCPGPNVMLNQQNPPAPQPQHLPRRPVKDIPPLMQTSIQGGIPAPGP-IPAAVPGPGPGS-LTPGGAMQPQVGMPVVGPVPLERGQMQISDPRPPMPRGPMPSGGIPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYMGPPHQGPPMHHG--HDNRGPASHDMRGGPLAADPRMLIGEPRGPMIDQRGLPMDGRGGRESRGMETRPMETEVLEPRGMERR-METCAMETRGMDAR-----GLEMRGPGPSSRGPMTGGIQGPGPINMGAGGP-QGPRQVPNIAGVGNPGGTMQGAGIQGGGMQGAGMQGGGMQGAGMQGGGMQGAGMQAGMQGASMQGGMQGAGMQGASKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H0L4-1", "uniprot_id": "CSTFT_HUMAN", "id": "Q9H0L4-1", "name": "Cleavage stimulation factor subunit 2 tau variant", "aln": "MSSLAVRDPAMDRS--LRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDS---PYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSH---QEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVS------------VSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPAPGP-IPAAVPGAGPGS-LTPGGAMQPQLGMPGVGPVPLERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLG-DPRLLIGEPRGPMIDQRGLPMDGRGGRDSRAMETRAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQG-------------GGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VE52-1", "uniprot_id": "Q9VE52_DROME", "id": "Q9VE52-1", "name": "", "aln": "MADKAQEQSIMDKS--MRSVFVGNIPYEATEEKLKEIFSEVGPVLSLKLVFDRESGKPKGFGFCEYKDQETALSAMRNLNGYEIGGRTLRVDNACTEKSRMEMQQL-LQGPQVEN---PYGEPCEPEDAPELITKTVASLPPEQMYELMKQMKLCIVSNP---SEARQMLMLNPQLAYALLQAMVVMRIVDPQQALGMLFKANQMPPVLGGN--------------------------PHQGPGNHTMMGQQQVPQQQVQ---------IPQQQQQAPQPPMPVPGPGFPANVHPNDIDLRMVPGGPMP-------MDPRMMGRG--MDQDLRASLPN-PVPPPLMDPR-----------------ARAQMPPQQQQGVP-QAPPAPYP--------------------------SDPR-----QR--PMDPR---------LR------------------------------------------------------AGPGPQQQ---APPQGIPQAP-------PPTQQQ-----------------------------------------------QAAAQQLQSRLG-------AHGVLPSDASDQEKAALIMQVLQLSDEQIAQLPSEQRVSIVMLKEQIAKSTQR--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25299-1", "uniprot_id": "RNA15_YEAST", "id": "P25299-1", "name": "mRNA 3'-end-processing protein RNA15", "aln": "MNRQSGVNAGVQNNPPSRVVYLGSIPYDQTEEQILDLCSNVGPVINLKMMFDPQTGRSKGYAFIEFRDLESSASAVRNLNGYQLGSRFLKCGYSSNSDISGVSQQQQQQYNNINGNNNNNGNNNNNSNGPDFQNSGNANFLSQKFPELPSGIDVNINMTTPAMMISSELAKKPKEVQLKFLQKFQEWTRAHPEDAVSLLELCPQLS------------------------------------------------------------------------------------------------------------FVTAELLLTNGICKVDDLIPLASRPQEEASATNNN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVNEVVDPAVLNKQKELLKQVLQLNDSQISILPDDERMAIWDLKQKALRGEFGAF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : :. ::.. * *::*.***: ***:: :: *:**.*:.:::::* ::*:.**:.* *::* *:: **:***** ::..* *: . :.... :. ::. *: : .:.*: . *.: .::: ** . :.: : . : :: :: :** .*: *: :* ::. : .* .* . .. . . : . . ::: *: *****. .**: ** ::* :* **:: :. ", "identical_positions": 57, "similar_positions": 108, "identity": "8.73%" }, { "cls_id": "homologset.agr.HGNC:17087", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JHJ8-1", "uniprot_id": "ICOSL_MOUSE", "id": "Q9JHJ8-1", "name": "ICOS ligand", "aln": "MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAASAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIE-NPEVSVTYYLP--YKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTG---NNTKNPQETHNNELKVLVPVLAVLAAAAFVSFIIYR---RTRPHRSYTGPKTV--QLELTDHA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LVL2-1", "uniprot_id": "F1LVL2_RAT", "id": "F1LVL2-1", "name": "ICOS ligand", "aln": "MQLK----------------------FFSGPGLFLLLFCSLCVEAEVKEVNAMVGSDVELRCVYPRRSHFSLDDLYVYWQIVDEAKTVVTYYLPSANESSTIHVSNSYKNRAHLSPDLMKEGDFSLHLQNVTPQDTQEFKCLVFR-MSTVLGKALEEVVRLRVAANFSTPVISTSGSSDPGQERTFTCMSKNGYPEPNLYWINRTDNTLIDETLQNNTVYLNELGLYDVVSTLRIPWTPHVDVICCVENVALHQNITSISRADSFTGS--MNTERPQEIHREATKVLFYVLAALLAVVVVIFIIVLYRCRRRPCQSYTGPRAV--QLELTDHS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75144-1", "uniprot_id": "ICOSL_HUMAN", "id": "O75144-1", "name": "ICOS ligand", "aln": "MRLG-------------------------SPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTS-ESKTVVTYHIP--QNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLS-QSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQ-DELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTG-EKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:* . **::**:.** . : .** *****:* * * *. :*.*..:***** :.:. ***::* :*. :*.. *:**. :* * .*:*** * ****** *:* * *: : : : *. * *:******.**:*:. *.. :* *:** * ****.**:**** ***:*:* :***:**:** *****:*.**:. *. :: **:*** *:**:* *:: . * *:.* . : . :**.* ..* . * :**:*. :* : ***.* ", "identical_positions": 127, "similar_positions": 83, "identity": "38.14%" }, { "cls_id": "homologset.agr.HGNC:17088", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7Z460-1", "uniprot_id": "CLAP1_HUMAN", "id": "Q7Z460-1", "name": "CLIP-associating protein 1", "aln": "----MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGG--FKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLS-KKGLPQSRLNVIFTKFDEVQKSGNMIQSAN-DKNFDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLR--LLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCT-SKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRSDIDVNAAASAKSKVSSSSGTTPFSSAAALPPGSYASLG--------RIRTRRQSSGSATNVASTP-DNRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLA------------------RSSRIPRPSMSQGCSRDTSRESSRDTSPARGFP---------------------PLDRFGLGQPGRIPGSVNAMRVLSTSTDLEAAVADAL--------KKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNG----------------GIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMD-PTDFVN--SSETRLAVSRIITWTTEPKSSDVR----------------------------------KAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNTS-VGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLAKHP--------PPFSQPNSIPTAPSHKALRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKECDIVSRDGGAASPATEGRGGSE--VEGGRTALDNKTSLLNTQPPRAFPGPRARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRDVPIDHS-------------DLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR--FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIG-EDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q80TV8-1", "uniprot_id": "CLAP1_MOUSE", "id": "Q80TV8-1", "name": "CLIP-associating protein 1", "aln": "----MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDRQKSADLEHDQTLLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGG--FKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLS-KKGLPQSRLNVIFTKFDEVQKSGNMIQSAN-EKNFDDEDSVDGNRPSSASSSSSKAPSSSRRNVNLGTTRRLMSSSLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLR--LLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCT-SKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTASRGSTVSTKSVSTTGSLQRSRSDIDVNAAASAKSKVSSSSGSPAFSSAAALPPGSYASLG--------RIRTRRQSSGSTTNVASTP-DSRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGS---GLAGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLA------------------RSSRIPRPSMSQGCSRDTSRESSRDTSPARGFT---------------------PLDRFGLGQSGRIPGSVNAMRVLSTSTDLEAAVADAL--------KKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNG----------------GIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMD-PTDFVN--SSETRLAVSRIITWTTEPKSSDVR----------------------------------KAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNTG-VGSPSNTIGRTPSRHPSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLSKPP--------PPFSQPNSIPTAPSHKTLRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKDCDIVSRDGGAASPATEGRGGSE--IEGGRMALDNKTSLLNTQPPRAFPGPRAREYNPYPYSDTINTYDKTALKEAVFDDDMEQLRDVPIDHS-------------DLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR--FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERITKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIG-EDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LNR1-1", "uniprot_id": "F1LNR1_RAT", "id": "F1LNR1-1", "name": "", "aln": "----MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGG--FKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLS-KKGLPQSRLNVIFTKFDEVQKSGNMIQSAN-DKNFDDEDSVDGNRPSSASSSSSKAPSSSRRNVSMGTTRRLMASSLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLR--LLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCT-SKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTASRGSTVSTKSMSTTGSLQRSRSDIDVNAAASAKSKVSSSSGSTAFSSAAALPPGSYASLG--------RIRTRRQSSGSTTNVASTSSDSRGRSRAKVVSQSQ---------PGSRSSSPGKLLGSGYGGLAGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIG---------------------------------------------------------------------------LDRFGLGQSGRIPGSVSAMRVLSTSTDLEAAVADAL--------KKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNG----------------GIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSK-VFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMD-PTDFVN--SSETRLAVSRIITWTTEPKSSDVRKFQRQRSRAGDDVPGRSVPTCSGPGEANLEESCKQAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNAG-VGSPSNTIGRTPSRHPSSRTSPLTSPTNCSHGGLSP-----------------------------------------------SMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKDCDIVSRDGGAASPATEGRGGSE--VEGGRMALDNKTSLLNTQPPRAFPGPRAREYNPYPYSDTINTYDKTALKEAVFDDDMEQLRDVPIDHS-------------DLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR--FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERITKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIG-EDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0AB32TUP5-1", "uniprot_id": "A0AB32TUP5_DANRE", "id": "A0AB32TUP5-1", "name": "", "aln": "----MEPNMEYCLTQVLQKDVARRLQMGPELIDYITDAEKCQDLESDQTALDKMVDGIATSWVNSSNFKLALLGMDLLSALVTRLQDRFRPQVGTVLPSLIDRLGDAKDQVRDQDQILLLKIMEQSATPQYIWDRMLGG--FKHKNNRTREGVCLCLISTLNTYGAQGLTLSKIVPHICNLLGDPTSQVRDAAMNCLVEIYRHVGEKVRIDLS-KKGLPQSRLNVIFSRFDEVQRSGNMILSSGSDKNFDDEDSVDGGR--SSSSSSSKGFSSSRRGGSMGSMRRPSSASGSRAAGKDGASAGALDEEDFIKAFEDVPAVQIYSSKELEDSLNKIREILSDDKQDWEHRVTALKKMRSLLMAGATEHEGFIQQLR--LLEGAFKMSAKDLRSQVVREACITLGHLSSLLGNKFDHGAESIMPTLLNLVPNSAKVMATSGVAAIRLILRHTHFPRLIPIITSNCT-SKSVAVRRRCYEFLDLLLQEWQTHTLERHVAVLTETIKKGIHDADSEARSVARKCYWGFHGHFSREAEHLFQALESTYQKALQSHLKSSDSIVSLPQSDRSSSSSQESLNRPLSVK-TVIGGPVTRSKVIGSRVSSSSGSLQRSRSDIDVNAASSAKSRMSTATSPSPFSAAAALPPGSYASLDGAPGKIDGRVRTRRQSSGSAVSANSTVTDSRGRSRAKVVSQSQRSRSANTTSAGSRSSSPGKLLGHAYGRIPRAT---APTTPS-DKYSRIPRSQGCSRETSPNRLGIARLCGKALLPATSPYRTLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFTPLASRRHSRSTSALSTAEPVGQSDRFGLIHQARISASVNAMRVLNTGTEVEAAVADALLLGDSRNKRKPLRRRYE-----SDDDANSDASSACSERSYSSRNG----------------GIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRILSRVELKRLCEIFTRMFADPHSK-VFSMFLETLVDFVTVHREDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDITRESFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMD-PGDFVN--SSETRLAVSRIITWTTEPKSSDVRKTLHN--WACEELSGRPSTTALLPGEGQLEERCKQAAQVVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNTSNVSSPSNTMGRTPARHPTSRTSPLTSPTNCSHGGLSPSRLWGWGVDGLLKHPSPSPPPPPPPPSSHSSIPAGPSLRALRCALSPSMLEYDTENMNSDEIFSSLRGVTEAIQSFSYRSQEDLNEPIRRDGKKDD---ATGKEAASPGSDARLGLDV-VEGGRTALDNKTSLLNTPSPRSFAGPRSREFAPYGYGDTITAYDKSALKEAVFDDDVEQFRDCRRQDCGENKMVLPKGFSPDLVADLLKELSNHNERVEERKGALIELLKITREDSLAVWDEHFKTILLLLLETLGDKDHTIRALALRVLKEILRNQPAR--FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLAGSIHPEQCIKVLCPIVQTADYPINLAAIKMQTKVVERITKESLHQLLPDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIG-EELKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSSHS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NBD7-1", "uniprot_id": "CLASP_DROME", "id": "Q9NBD7-1", "name": "CLIP-associating protein", "aln": "MAYRKPSDLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVCTDMGFLIDGLMP-----WLTGSHFKIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRERPTRMIKRPLHSAVSSSLRPKPNVNDVTG-------DAGAVTMESFESSFEVVPQLNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGG-----GGGTGTGTGTAPETRRTVSRIGRTPGTLQKPTPSMRSISAVDTAAAQRAK----VRAQYTLYSRQRKPLGPNNSNQASMTGAAASGSLP----------RPRLNSNSGGTPATTPGSVTPRPRGRAGVSQSQ---------PGSRSTSPSTKLRDQYGGIGNYYR--GATGAIPKKASGIPRSTASSRETSPTRSGGG---------------------LMKRSMYSTGAGSRRTPERNNPVRPS--------------------------------AAARLLAQSREAEHTLGVGDDGQPDYVSGDYMR-----SGGMRMGRKLMGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSLFLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELR----------------------------------SQARSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSSPKPLQSPSVGPFASLQSHHHQLSISSTSPRS-----------------------------------RQSSVEQELLFSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLERERTTQNAKSPTDDAKVITVSINMAENGELILASNLMESEVVRVALTLTK--------------------------DQPVELLQTSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQHS-KEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSSTKNSSAASSS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: : *: : *: ::*:. :*: :::* :. :* :: *:..*::*:. .:: :* *:.** . *.. .**** :******::* **:: * ** .:*:: . * *. ***** :.** . :: :*: *:* *:: :* :* *****. :**:**:: *****:***:::* ** ..:* *:* :: :**:*::.* :: *: :.* :. . :... . .: . : . . : .***: *.* .:*: ** ::*: :::::: ::: *:**.: ***:** ****:*:**: . *. * . ..: ::*****:******:.::*. * **:* . :*: ::**: ****::*::.. *:: *:::** *:*: : *.. . *** :* *:: **::****::***: :** :*:**.* ***.:** :* .**.*: **.. *:::: :*: : *:**: . :... . :.:.: . .*.:* * . : : :.: **:: *.* : *: .. .. . *: ..: .** *.* :*... . . :. . ***** .****:**.. * : .. . .* * **** ..******.* * :. * .* :.*... : :. ... :* : ..** :*:***.*****:.* . . :*: :::.***::*****:**:.* : * . : *:: :** : ::* :** *.*:* *:*:**:*:.::: :* ::*::***:***:*::*:*:***.*:::*: *:*::.:: ** : *:: *:*:* *.****. *.::***::: .**. . ** . *. . :* :: ::: ** ::* . *: *::*::****::*:**. ***.:**.* . :*.*::..*:: .: * : . .: ... ** ..* . :. * :: : .. :* .:: .:* *. . : * :*: : . .** .::.: . .. . . . * * *: ..:: . :*. :: * * : * .* :: ** : :* :* : .. : ::**::*: :**: * :. : .*:** :*:*.: * : :: ** ::* ::.::.* **.:* :. . :* *: : .*::: *:: *.::* **.***: :*.*: .* * ::*.* :. *:*:* ****:***:* :* *:* *.:**:*: *. **::***:**:: :. *...**:. *: : ", "identical_positions": 402, "similar_positions": 523, "identity": "23.82%" }, { "cls_id": "homologset.agr.HGNC:17089", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LEP2-1", "uniprot_id": "A0ABK0LEP2_RAT", "id": "A0ABK0LEP2-1", "name": "Nesprin-1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATSRASSRSHRDITNVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGIKLLALLEVLSGQKLPCEQGHRGKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINATDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQS-LSSSASSVDSMVSTETASPPSKRKVATKVQGNAKKTLLKWVQHTAGKQMGIEVKDFGKSWRTGLAFHSVIHAIRPELVDLEKVKNRSNRENLEDAFTIAETQLGIPRLLDPEDVDVDKPDEKSIMTYVAQFLTQYPDIRGAGYDVQEN---------------------------DRDDRLILKEAKVWIEQFERDLTRAQMTESNLQDKYQSFKHFRVQYELKRKQVEHIIQPLQRDGKLTLDQALVKQCWERVSSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPMPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQSYISFIENSKFFEQYEVTYQVLKQTAEMYVKADGS-------VEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGDTVASLQAWLEDAEKMLSQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEIVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYTDGTAALSGFAAEAHRKLSEPLEVSFMN-VKLLIQDLEDTEKRVPVMDAQYKMIAKKAHLIAKESPKEEANEMLTTMSRLKEQLSKVKECYSPLLYEAQQLSVPLEELETQITSFYDSLGKINEILAVLEHEAQSSALFKQKHQELLACQESCKKSLTFIEKGSQSVQKLVTSSQALKHWDHTKLQKQIADVHHAFQNMIKKTGDWKKHVEANSRLMKKFEESRAELEKVLRAAQEGLEEKGDP-EELLRKHTDFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIAVEKDRFSAAVEECRAELERETKLAS-QEGSEKIIKEHRVFFSDKGPHHLCEKRLRLIEELCVKLPVRDPV----RDTSGACHTALKELKASIDNTYMMLMDDPDKWTDYASRFSELSSWVSAKESWLKNIKDQPIDTGNHDEVKRVADEMRNDITKKGEILSWLKSRLKHLIDVSSENEAQKRGDELAELSSSFKALVALLSEVEKMLSNFGECVQYKEIVKS-----SLEGLMSGSEESKDEAETILDTENLFEAQQMLLRHQQKTKMISAKKRDLQQQMEQG--QQG--GQAGPGQEELRKLESTLTGLEQSRERQERRIQVSLRKWERFETNKETVVRYLFQTGSSHERFLSFSS-LESLSSELEQTKEFSKRTESIATQAEN---LVKEAAEMPLGPRNKRLLQQQAKSIKEQVKTLEDTLEEDIKTMEMVKTKWDHFGSNFETLSNWITEKE-NELSSLETSASAMEMQINQIKVTIQEIEGKIESVVGLEEAAQSFAQFIT-TGESARIKAKLTQIRRYWEELQEHARGLEGVILGQLSQQQKFEENLRKIQQSVSEFAERLAEPIKICSSAAETYKVLQEHMDLCQALESLSSTVTAFSASAQKVVNRESSTQETAALQQQYEEILHKAKERQKALEDLLAHWQRLEKGLSPFLTWLERCEAIARSPEKDIAADRV-KVDSELQLIQALQNEVVSQASLYSNLLQLKEALFSAASKEDVAMMKLQLEQLDERWGDLPQIISKRMLFLQSVLAEHRQFDELLFSFSVWIKQFLSELQMTSEINLRDHQVALTRHKDHATEIEKKRGEVKHLQGHLAQLRSLGRAEDLHPLQSKADDCFQLFEEASQVVERRKLALTQLAEFLQRHASVSTLLHQLRQTVEATKSMSKKQSDSLKKDLHDAIQDVKTLESSAIGLDGTLTKAQCHLKSGSPEQRTSCRATTDQLSLEVERIQNLLGTKQSEADALLVLKEAFQEQREELLRSIEDIEERTDRERLKEPTRQALQHRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVALAPEVDREINRLEATWDDTKRLIHENQGQCCGLIDLVREYQNLKSAVCKVLEDASHVVEMRAT-IKDQEDLKWAFSKHETSRNEMNSKQKELDSFTSKGKHLLSELKKIHSGDFS--LVKTDMESTLDKWLDVSERIDENMDRLRVSLSTWDDVLSSRDEIEGWSNSSLPQLAENISDLNNSLRAEEFLKELESEVKNKALKLEELHSKINNLKELTKNPETPTELQFIEADLRQKLEHAKEITEEAKGTLKDFTAQSTQVERFVKDITAWLVNVEESLTRYAQTYT-----CEGLKKVKDIRKELQSQQNNIISTQEVLNSLCRKHHSVELESRGRAMTGLIKKHEATSQLCSQTQASIQDSLEKHFSGSMKEFQEWFLGAKAAARESS-NLTGDSQVLEARLHDLQGVLDSFSDGQSKLDAVTQEGQTLYAHLPKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCVSELGSFEDQHRKLNLWIHEMEERSNT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENLGESRHHISEKKNEIHKVEMFLGELLAARESLDKLSQRGQLLSEES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGAGKGGRRSTQLLANYQNLLRVTKERLRGCQLALQEHEALEEAMQSMWSRVKDVKDRLACAESTLGDKETLEWRLSQIQDILLMKGEGEVKLNLAIGKGDQASKSSNKEGQQAIQDQLETLKKAWADAMSSAVHAQSTLESVIDQWNDYLEKKSQLEQWMESVDQKVEHPLQLQPGLKEKFSLLDHFQSIVSEAEDHTGALQQLAAKSRELYKKTQDESFKEAVQEELRTQFQDILTVAKEKMRTVEDLVKDHLMYFDAVQEFTDWLHSAKEELHRWSDTSGDSSATQKKLSKIKELMDSREI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAGRLSRVELLAPSVKQNTAASGCELLNSEMQALRADWRQWEDCLLQTQSSLEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVSEMALSEQEFSGQVARLEQALEQFSTLLKTWAQQLTLLEGKSTDEEIVECWHKEREILDALQKAEPMTEDLKSQLNELCRFSRDLSPYSGKVSGLIKEYNCLCLQASKGCQSKEQILQER----------------FQKASKSFQQWLVNAKITTAKCFDLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNLSEVSSSLQKIQEFLSESETGQHKLNTMLSKGELLSSLLTKEKAQAVQAKVLTAKEDWKHFHANLHQKESALENLKIQMKDFEVSAEPVQNWLSKTKRLVQESSIRLY-DLPAKRREQQKLQSVLEEIQCYEPQLHRLKEKARQLWEGQAASKSFVHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGVKELQDWMSDAVHMLDSYCLPTSDKSVLDGRMLKLEALLSVRQEKEIQIKMIMTRGEYVLQSTSPEGSHAVQQQLQALKEKWESLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDVVEVSLTELERQ------------HTELREKVTTLGKAKLLNEEVLSHGSLLETIQVKRAAMTEHYVTQLELQDLQERHQVLKEKAKETVTKLEKLVRLHQEYQRDLKAFENWLGQEQEKLDRSSVLEGDTNAHETTLRDLQELQVRCAEGQALLNSVLHTREDVILSGLP---QAEDRVLESLRQDWQVYQHRLAETRMQFNNVANKLRLMEQKFQEADEWLQRMEEKISVRNERQSSRSAKEIQLLQLKKWHEDLSAHRDEVEEVGSRAQEILDESRVSSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQCLEETESSLSSYSDWYGSTHKNFKNVATK-IDKVDEAMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKFLEGSEAEALRKEIHAHMEQLKNLTSAVRKEHVSLEKGVHLAKEFSEKYKVLTRWLAEYQEILLTPEEPKMELYEKKAQLSKYKSLQQMVLSHEPSMNSVQE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSEALLELVQDQTLKDK------------------------------------------------------------------------------------------------------------------IQKLQSDFQDLCSIGKERVFSLEAKVRDHEDYNTELQEVEKWLLQMSGRLAAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLDNLKAKGDTLIGQCPDHLQAKQKQSVQAHLQGTKDSYSAICSTAQRVYRSLEYELQKHVSRQDTLQQCQAWISAVQPDLKPSPQPPLS----RAEAVKQVKHFRALQEQARTYLDLLCSMCDLSNSSVKNTAKDIQQTEQLIEQRLVQA----------------------------------------------------QNLTQGWEEIKNLKAELWIYLQDADQQLQNMKR--RHAELEINIAQNMVLQVKDFIKQLQC----------------KQASVSTITEKVDKLTKNQESPEHKEISHLNDQWQDLCLQSDKLCAQREQDLQRTSS-------YHDHMSIVEAFLEKFTTEWDNLARSNAESTAVHLEALKKLALALQEK-KFAIDDLKDHKQKLMEQLSLDDRELLREQTSHLEQRWFQLEDLVKRKIQVSVTNLEELNVVQSRFQELTEWAEEQQPNIVEALKQSPPPGTAHHLLTDHLAICSELEAKQVLLKSLMKDADRVMADLGLNERKVIQKVLSEAQKHVSCLNDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHE-RKIMFREYVCLLPDDVSKQVKTCKTAQASLKTYQN-EVTGLWTQGRELMKGITEQERNEVLGKLQELQSVYDTILQKCSHRLQELEKSLVSRKHFKEDFDKAQHWLKQADIVTFPEINLMNERVELHAQLDKYQSILEQSPEYENLLLTLQTTGQAMLPSLNEVDHSYLSEKLSAMPQQFNVIVALAKDKFYKIQEAILARKEYASLIELTTQSLGDLEDQFLKMRKMPSDLIVEESVSLQESCRTLLGEVVALGEAVNELNQKKESFRSTGQPWQPEKMLQLATLYHRLKRQAEQRISLLEDTTSAYREHAQMCQQLESQLEVVKREKAKVNEETLP-AEEKLKVYHSLAGSLQDSEILLKRVAVHLEDLSPHLDPMAYEKGKGQVQTWQEELKQMMSEIGEMVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVCLDLR-LQDIQEEIRKIQIHQEEILSSLRIMSALSQKEQEKFTKAKELISADLEHTLAELKELDGDVQEALRTRQATLTEIYSQCQRYYQVCQEANDWLEDAQEMLQLVGNGLDVESAEENLKSHMEFFKTEGQFH-SHMEELRGLVARLDPLIKPTGKEELAQKMASLEKRSQGVIQDSHTQRDLLQRCSVQWQEYQEAREGVIKLMNDVEKKLSEFVVTKISSSHEAEEKLSEHRALVSVVDSFHEKIVALEEKASQLEQTGNEANKATLSRSMTTVWQRGTRLRAVVQDQEMILEDAVDEWKALSAKIKENTEIINQLQGRLP--GTSTEKTS-KAELIALLESHDTFAMDLERQQLALGVLQQRALSMLQDGALPGP---KEEVPTLQEITALQDQCLNMQEKVKNHGKLLKQELQEREAVETCINSVKSWVQETKDYLGNPTLEVDTQVEELKSLLAEATSHRESIEK---IAEEQKNKYLGLYTILPSEISLQLAEVALDL-KIHDQIQEKVQEIEQGKAMSQEFSCQIQKVAKDLTTILTKLKAKTDNLVQAKADQKMLGEELDSCNSKLMELDTAVQTFSE--QHGQLGKPLAKKIGKLTELYQQTIRQAENRLSKLNQASSHLEEYSEMLESIQKWIEKAKVLVQGNIAWNSASQLREQYILHQTLLEESEEIDSDLETMAEKVQYLANVYCTGKLSQQVTQLGRETEELRQAIRVRLQSLQDAAKDMKKFEGELRNLQVALEQAQTILTSPEVGRLSLKEQLSHRQHLLSEM--------------------------------------------------------------------------------------------------------------------------------ESLKPKVQAVQLCQSALRIPEDVVTGLPLCHAALRLQEEASQLQHTAIQQYNIMQAGATAQRVQPAGPTL------EAVVQYEQYGQEMKHLQQLIEAAHREIEDKPVATGNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG---------LAEGTEDVDP---ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTEASVNQDIAYYQALSAEGLQTDAARIAPSAAASQELYEPGLEPSATAKLGDLQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WETLKNVISEKQRTLYEALERQQKYQDSLQSVSTKMEAMEMKLSESLQP---------GRSPESQMAEHQALMDEVQMLQDEINGLQASLAEELVAE--SQESDPAEQLALQSTLTVLAERMSTIRMKAAG--------------------------------------------------------------------------------------------------------------------------------KRQLLEEKLNDQLEEQRQEQALQRYRCEAEELDHWLLNTKATLDFAAGIPQEPMDMDAQLVDCQNMLVEIEQKVVALSQLSVRS-ENLLLEGKAHTKDEAEQLASKLRMLKGSLMELQRALRDRQLNMQG---------------------------------------------------VTQEKEENDVDFTATQSPGVQEWLAQARNTRTHQRQSSLQQQKEFEQELAEQK-----------------------------------------------------------------------SLLRSVASRGEEILIQHSTAEGSGGLGEKPDALSQELVMEGAKSFAEDQMRAKWESLHQEFSTKQKLLQNILEQEQEQMLYSSPNRLLSGVLPLRGEAQTQDKSSVTSLLDGLSQAFGEVSSQSGGTDRQNIHLEQKLYDG-----------------------------------------------------------------------------------------------------VSATSTWLDDVEEHLFVATALLPEETETCLFN---------QEALAKDIKEMSEEMDKNKNLFS--QAFPEDS------------------------------------------------------------------------------------------------------------------------------------------------------------------DNRDVIEDTLGCLLGRLSLLDSVVGQRCHQMK--------------------------------------ERLQQVLSFQNDLKVLFTSLADNNYIILQKLANMFKQPIVEQIQAIQQAEEGLRELDGGISELKQRGDKLQVDQ------------------------------------------SALQELSKLQDMYDELLVTISSRRSNLNQNLALKSQYDKALQDLVDLLDTG-----------------------------------------------------------QEKMAGDQKIIVSSKEEVQQLLSKHKEYFQGLESHLILTETLFRKIVDFAAMKETQLHSDRMAQASAVLKQAHKRGVELEYILEMWSHLDENLQELSRQLEVIENSIPSVGLVEESEDRLVERTSLYQHLKSSLNEYQPKLYQVLDDGKRLMMSISCSELESQLNQLGERWLGNTNKVSKELHRLETILKHWTRYQSEAADLIHWLESAKDKLAFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAKSSLKSSVTSTGNQLLRLKKVDTAALRAELSCMDSQWTDLLAGIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMESVILKDEEDIRNAIGYKAIYEYLQKYKGFKIDLNCKQLTADFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQLLQGRVGEKIQMLEGLLESWSEYENSIQSLKAWFANQERKLEEHHQIGDQNSVQNALKDCQELEDLIKAKEKEVEKIEQNGLALIQNKREEVSCSVLN-TLWELRQTWASLERTVGQLKIQLTLVLGQWSIHKAAFEEISNHLMEARYSLSRFRLLTGS-SDAVQVQVDNLQNLHDDLEKQEGDLQKFGSLTNHLLKECHPPVAEALSSTLQEVNMRWNNLLEEIAKQLHSSKALLQLWQRYKDYSKQCASAVQRQEEQTNALLKAATSKDIADDEVAKWIQDCNDLLKGLGTVKDSLFILHELGEQLGQQVDDSAATTIQCEQLCFSQRLEALEQALCKQQAVLQAGVVDYETFAKSLEALEAWIVEAEGILQAQDPTHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELG----YRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEHKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIVDGQNLLEQGQVDDREEFSLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSHLPLSGLGSIPVPLQQVRTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTDIQEKWKSASTHLEEQK---KKLAFLLKDWEKCEKGIADSLEKLRTFKKRLSQPLPDHHEELHAEQMRCKELENAVGRWTDDLAELVLLREALAAHLSAEDISILKERVELLQRQWEELCHQVSLRRQQVSERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENK-----IQLQQMGERLAKASHESKASEIQYKLSKVNDRWQHLLDLMAARVKKLKETLVAVQQLDKNMGSLRIWLAHMESELAKPIVYDSCNSEEIQKKLSEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLEISERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLRQMAHGGNQRWDDLQKRVTSILRRLKHFISQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHSKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDHDLS--DRELDLEDSMALSDLHWQDPSEDGMPSPQPSSNPSLSLPQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAS-RTLPSEDEEGEEDKEFYLRG-AVGLSDVVIPENPEAYVKLTENAIRNTSGDPTSLESQMRQLDKALDDSRFQIQQTAN-ILRGKTPTGPDLGTSYKGYMKLLGECSGSIDSVRRLEHKLAEEE-SFPGFTNPTS--TETQPAGVIDRWELLQAQAMSKELKMKQNLQKWQQFNSDLNNICAWLGETEEELDRLQHLALSTDIHTIKSHIKKLKELQKALDHRKAIILSINLCSSEFTQA--DSKESHDLQDRLSQMNRRWDRVCSLLEDWRGSLQDALMQCQDFHEMTHALLLLLENTDRRKNEIVPIDSTLDPETLQDHHTQLTQIKQELLKSQLRVASLQNMSRQLLVNAEGSDCLEAKEKVHVIGNRLKLLLKEVSRHIKDLEKLLGMSSSQQDLSSWSSADEVDTSGSVSPTSGRSTPNRQKSPRGKCSLSQPGPSVSSPKSRSTKG-GSDSSLSETRPARAG------RDFLFRVLRAALPIQLLLLLLIGLTSRVPISEEDYSCALSNNFARSFHPMLRYTNGPPPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZWR6-1", "uniprot_id": "SYNE1_MOUSE", "id": "Q6ZWR6-1", "name": "Nesprin-1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATSRASSRSHRDITNVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGIKLLALLEVLSGQKLPCEQGHRVKRIHAVANIGTALKFLEGRK-------IKLVNINATDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQS-LSSSASSVDSMVSTETASPPSKRKVAAKIQGNAKKTLLKWVQHTAGKQMGIEVKDFGKSWRTGLAFHSVIHAIQPELVDLEKVKTRSNRENLEDAFTIAETQLGIPRLLDPEDVDVDKPDEKSIMTYVAQFLTQYPDIHGAGCDGQEDDVVFVGFTNNIAL----------LLGFQRDDRLILKETKVWIEQFERDFTRAQMTESSLQDKYQAFKHFRVQYEMKRKQVEHIIQPLQRDGKLTLDQALVKQCWERVSSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYQTRSVNGIPMPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQSYISFIENSKFFEQYEVTYQILKQTADIYVKAEGS-------VEEAENVMKFMSEATAQWRNLSVEVRSVRSMLEEVISNWDRYGDTVASLQAWLEDAEKMLSQSEHAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEIVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYIDVTTTLFGFATEAHRKLSEPLEVSFIN-VKLLIQDLEDLEKRVPVMDAQYKMIAKKAHLFAKESPQEEANEMLTTMSKLKEQLSKVKECCSPLLYEAQQLTVPLEELETQITSFYDSLGKINEILSVLEQEAQSSTLFKQKHQELLASQENCKKSLTLIEKGSQSVQKLVTSSQARKPWDHTKLQKQIADVHHAFQSMIKKTGDWKKHVEANSRLMKKFEESRAELEKVLRVAQEGLEEKGDP-EELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIAVEKDRFSAAVEECRAELEQETKLAP-QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCGKLPVQDPV----RDTCGACHTALKELKASIDNTYTMLVDDPDKWKDYTSRFSEFSSWVSAKKACLKKIKDEPIDTGNHDEVKHMVDEIRNDITKKGESLSWLKSRLKYLIDISSENEAQKRGDELAELSSSFKALVALLSEVEKLLSNFGECVQYKEIVKS-----SLEGLISGPQESKEEAEMILDSKNLLEAQQLLLHHQQKTKMISAKKRDLQEQMEQA--QQG--GQAGPGQEELRKLESTLTGLEQSRERQERRIQVSLRKWERFETNKETVVRYLFQTGSSHERFLSFSS-LESLSSELEQTKEFSKRTESIATQAEN---LVKEAAELPLGPRNKRVLQRQAKSIKEQVTTLEDTLEEDIKTMEMVKSKWDHFGSNFETLSIWILEKE-NELSSLEASASAADVQISQIKVTIQEIESKIDSIVGLEEEAQSFAQFVT-TGESARIKAKLTQIRRYWEELQEHARGLEGTILGHLSQQQKFEENLRKIRQSVSEFAERLADPIKICSSAAETYKVLQEHMDLCQAVESLSSTVTMFSASAQKAVNRESCTQEAAALQQQYEEILHKAKEMQTALEDLLARWQRLEKGLSPFLTWLERCEAIASSPEKDISADRG-KVESELQLIQALQNEVVSQASLYSNLLQLKEALFSVASKEDVAVMKLQLEQLDERWGDLPQIISKRMHFLQSVLAEHKQFDELLFSFSVWIKQFLGELQRTSEINLRDHQVALTRHKDHAAEIEKKRGEITHLQGHLSQLRSLGRAQDLHPLQSKVDDCFQLFEEASQVVERRKLALAQLAEFLQSHACMSTLLYQLRQTVEATKSMSKKQSDSLKTDLHSAIQDVKTLESSAISLDGTLTKAQCHLKSASPEERTSCRATTDQLSLEVERIQNLLGTKQSEADALVALKEAFREQKEELLRSIEDIEERMDRERLKVPTRQALQHRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINGLEATWDDTRRQIHENQGQCCGLIDLVREYQSLKSTVCNVLEDASNVVVMRAT-IKDQGDLKWAFSKHETSRNEMNSKQKELDSFTSKGKHLLSELKKIHSGDFS--LVKTDMESTLDKWLDVSERIEENMDMLRVSLSIWDDVLSRKDEIEGWSNSSLPKLAENISNLNNSLRAEELLKELESEVKIKALKLEDLHSKINNLKELTKNPETPTELQFIEADLRQKLEHAKEITEEARGTLKDFTAQRTQVERFVKDITAWLINVEESLTRCAQTET-----CEGLKKAKDIRKELQSQQNSITSTQEELNSLCRKHHSVELESLGRAMTGLIKKHEATSQLCSQTQARIQDSLEKHFSGSMKEFQEWFLGAKAAARESS-NLTGDSQILEARLHNLQGVLDSLSDGQSKLDVVTQEGQTLYAHLPKQIVSSIQEQITKANEEFQAFLKQCLKEKQALQDCVSELGSFEDQHRKLNLWIHEMEERLKT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENLGESKHHISEKKNEVRKVEMFLGELLAARESLDKLSQRGQLLSEES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSAGKGGCRSTQLLTSYQSLLRVTKEKLRSCQLALKEHEALEEATQSMWARVKDVQDRLACAESTLGNKETLEGRLSQIQDILLMKGEGEVKLNLAIGKGDQALRSSNKEGQQAIQDQLEMLKKAWAEAMNSAVHAQSTLESVIDQWNDYLEKKSQLEQWMESVDQRLEHPLQLQPGLKEKFSLLDHFQSIVSEAEDHTGALQQLAAKSRELYQKTQDESFKEAGQEELRTQFQDIMTVAKEKMRTVEDLVKDHLMYLDAVQEFADWLHSAKEELHRWSDTSGDPSATQKKLLKIKELIDSREI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAGRLSRVESLAPAVKQNTAASGCELLNSEMQALRADWRQWEDCLFQTQSSLES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVSEMALSEQEFFGQVTQLEQALEQFCTLLKTWAQQLTLLEGKNSDEEILECWHKGREILDALQKAEPMTEDLKSQLNELCRFSRDLSPYSEKVSGLIKEYNCLCLQASKGCQNKEQILQER----------------FQKASRGFQQWLVNAKITTAKCFDLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNLSEVSSSLQKIQEFLSESENGQHKLNTMLFKGELLSSLLTEEKAQAVQAKVLTAKEEWKSFHANLHQKESALENLKIQMKDFEVSAELVQNWLSKTERLVQESSNRLY-DLPAKRREQQKLQSVLEEIQCYEPQLHRLKEKARQLWEGQAASKSFVHRVSQLSSQYLALSNVTKEKVSRLDRIIAEHNRFSQGVKELQDWMSDAVHMLDSYCLPTSDKSVLDSRMLKLEALLSVRQEKEIQMKMVVTRGEYVLQSTSLEGSAAVQQQLQAVKDMWESLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEVSLTESEKQ------------HTELREKITALGKAKLLNEEVLSHSSLLETIEVKRAAMTEHYVTQLELQDLQERHQALKEKAKEAVTKLEKLVRLHQEYQRDLKAFESWLEQEQEKLDRCSVHEGDTNAHETMLRDLQELQVRCAEGQALLNSVLHTREDVIPSGLP---QAEDRVLESLRQDWQVYQHRLAEARMQLNNVVNKLRLMEQKFQQADEWLKRMEEKINFRSECQSSRSDKEIQLLQLKKWHEDLSAHRDEVEEVGTRAQGILDETHISSRMGCQATQLTSRYQALLLQVLEQIKFFEEELQCLEETESSLSSYSDWYGSTHKNFKNVATK-IDKVDESMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAMKFLAEHEAEALRKEIHTYMEQLKNLTSTVRKECMSLEKGLHLAKEFSDKYKVLAQWMAEYQEILCTPEEPKMELYEKKAQLSKYKSLQQMVLSHEPSVTSVQE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSEALLELVQDQSLKDK------------------------------------------------------------------------------------------------------------------IQKLQSDFQDLCSRAKERVFSLEAKVKDHEDYNTELQEVEKWLLQMSGRLVAPDLLEMSSLETITQQLAHHKAMMEEIAGFEDRLDNLKAKGDTLIGQCPEHLQAKQKQTVQAHLQGTKDSYSAICSTAQRVYRSLEYELQKHVSSQDTLQQCQAWISAVQPDLKPSPQPPLS----RAEAVKQVKHFRALQEQARTYLDLLCSMCDLSNSSVKNTAKDIQQTEQLIEQRLVQA----------------------------------------------------QNLTQGWEEIKSLKAELWIYLQDADQQLQNMKR--RHTELEINIAQNMVMQVKDFIKQLQC----------------KQVSVSTIVEKVDKLTKNQESPEHKEITHLNDQWQDLCLQSDKLCAQREQDLQRTSS-------YHDHMRVVEAFLEKFTTEWDSLARSNAESTAIHLEALKKLALALQEE-MYAIDDLKDCKQKLIEQLGLDDRELVREQTSHLEQRWFQLQDLVKRKIQVSVTNLEELNVIQSRFQELMEWAEEQQPNIVEALKQSPPPGMAQHLLMDHLAICSELEAKQVLLKSLMKDADRVMADLGLNERKVIQKALSEAQKHVSCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHE-RKIVFREYICLLPDDVSKQVKTCKTAQASLKTYQN-EVTGLCAQGRELMKGITKQEQEEVLGKLQELQTVYDTVLQKCSHRLQELEKSLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNEKTELHAQLDKYQSILEQSPEYENLLLTLQTTGQAMLPSLNEVDHSYLSEKLSALPQQFNVIVALAKDKFYKTQEAILARKEYTSLIELTTQSLGDLEDQFLKMRKMPSDLIVEESVSLQQSCSALLGEVVALGEAVNELNQKKESFRSTGQPWQPEKMLQLATLYHRLKRQAEQRVSFLEDTTSVYKEHAQMCRQLESQLEVVKREQAKVNEETLP-AEEKLKVYHSLAGSLQDSGILLKRVATHLEDLSPHLDPTAYEKAKSQVQSWQEELKQMTSDVGELVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVCLDLS-LQDIQEEIRKIQIHQEEVLSSLRIMSALSHKEQEKFTKAKELISADLEHTLAELQELDGDVQEALRTRQATLTEIYSRCQRYYQVFQAANDWLDDAQEMLQLAGNGLDVESAEENLRSHMEFFKTEGQFH-SNMEELRGLVARLDPLIKATGKEELAQKMASLEKRSQGIIQESHTQRDLLQRCMVQWQEYQKAREGVIELMNDAEKKLSEFAVLKTSSIHEAEEKLSKHKALVSVVDSFHEKIVALEEKASQLEQTGNDTSKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWKRLSAKVKETTEVINQLQGRLP--GSSTEKAS-KAELMTLLESHDTYLMDLESQQLTLGVLQQRALSMLQDRAFPGT---EEEVPILRAITALQDQCLNMQEKVKNHGKLVKQELQEREAVETRINSVKSWVQETKDYLGNPTIEIDTQLEELKRLLAEATSHQESIEK---IAEEQKNKYLGLYTVLPSEISLQLAEVALDL-KIHDQIQEKVQEIEEGKAMSQEFSCKIQKVTKDLTTILTKLKAKTDDLVHAKAEHKMLGEELDGCNSKLMELDAAIQTFSE--RHSQLGQPLAKKIGKLTELHQQTIRQAENRLSKLNQALSHMEEYNEMLETVRKWIEKAKVLVHGNIAWNSASQLQEQYILHQTLLEESGEIDSDLEAMAEKVQHLANVYCTGKLSQQVTQFGREMEELRQAIRVRLRNLQDAAKDMKKFEGELRNLQVALEQAQTILTSPEVGRRSLKEQLCHRQHLLSEM--------------------------------------------------------------------------------------------------------------------------------ESLKPKMQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASQLQHTAIQQCNIMQAKKHSLIFPPK----------EAVVQYEQYKQEMKHLQQLIEEAHREIEDKPVATSNIQELQAQISLHEELAQKIKGYQEQIDSLNSKCKMLTMKAKHATMLLTVTEVEG---------LAEGTEDLDR---ELHPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTEAAVNQDIAYYQALSAEGLQTDAARIPPSAAVSQELYEPGLEPSATAKLGDLQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WETLKNVISEKQRTLYEVLERQQKYQDSLQSISTKMEAMEMKLGESLEP---------SRSPESQMAEHQALMDEVQMLQDEINGLQVSLAEELVAE--SQESDPAEQLALQSTLTVLAERMSTIRMKAAG--------------------------------------------------------------------------------------------------------------------------------KRQLLEEKLSDQLEEQRQEQALQRYRCEADELDHWLLNTKATLDVALGTSQEPMDMDAQLVDCQNMLVEIEQKVVALSQLSVHN-ENLLLEGKAHTKEEAEQLAVKLRLLKGSLGELQRALHDRQLDMQG---------------------------------------------------VTQEKEENDVDFTDTQSPGVQEWLAQARTTRTHQRQSSLQQQKEFEQELAEQK-----------------------------------------------------------------------SLLRSVASRGEEILTQHSTAEGSGGLGEKPDVLSQELG------IAEDQMRVKWESLHQEFSAKQKLLQNILEQEQEQVLYSSPNRLLSGVLPFRGEAQTQDKTSVTSLLDGLSQAFGEASSQSGGTDRQSIHLEQKLYDG-----------------------------------------------------------------------------------------------------VSATSTWLNDVEERLFVATAPLPEETEACLFN---------QEALAKDIKEMSEEMDKNKNLFS--QAFPEDS------------------------------------------------------------------------------------------------------------------------------------------------------------------DNRDVIEDTLGCLLGRLSLLDSVVDQRCHQMK--------------------------------------ERLQQILRFQNDLKVLFTSLADSKYIILQKLANVFEQPIVEQMQAIQQAEEGLRDLEGGISELKRWADKLQVEQ------------------------------------------SAVQELSKLQDMYDELLMTVSSRRSSLHQNLALKSQYDKALQDLVDLLDTG-----------------------------------------------------------QEKMTGDQKIIVCSKEEIQQLLGKHKEYFQGLESHMILTEILFRKIVGFAAVKETQFHTDCMAQASAVLKQAHKRGVELEYILEMWSHLDENRQELSRQLEVIENSIPSVGLVEESEDRLVERTNLYQHLKSSLNEYQPKLYQALDDGKRLLMSVSCSELESQLNQLGEHWLSNTNKVSKELHRLETILKHWTRYQSEAAALNHWLQCAKDRLAFWTQQSVTVPQELEMVRDHLSAFLEFSKEVDAKSALKSSVTSTGNQLLRLKKVDTAALRAELSRMDSQWTDLLTGIPVVQEKLHQLQMDKLPSRHAISEVMSWISLMESVILKDEEDIRNAIGYKAIHEYLQKYKGFKIDLNCKQLTADFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQLLQGRVGEKIQMLEGLLESWSEYENSVQSLKAWFANQERKLKEQHLLGDRNSVENALKDCQELEDLIKAKEKEVEKIEQNGLALIQNKREEVSGSVMS-TLQELRQTWISLDRTVEQLKIQLTSALGQWSNHKAACDEINGHLMEARYSLSRFRLLTGS-SEAVQVQVDNLQNLHDELEKQEGGLQKFGSITNQLLKECHPPVAETLSSTLQEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCASAIQRQEEQTSVLLKAATNKDIADDEVTKWIQDCNDLLKGLETVKDSLFILRELGEQLGQQVDVSAAAAIQCEQLCFSQRLGALEQALCKQQAVLQAGVVDYETFAKSLEALEVWMVEAEGILQGQDPTHSSDLSTIQERMEELKGQMLKFSSLAPDLDRLNELG----YRLPLNDKEIKRMQNLNRHWSLTSSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEHKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIVDGQNLLEQGQVDDREEFSLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLAEVSHLPLSGLGNIPVPLQQVRMLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTDIQEKWKAASMHLEEQK---KKLAFLLKDWEKCERGIANSLEKLRMFKKRLSQPLPDHHEELHAEQMRCKELENAVGRWTDDLTELMLVRDALAVYLSAEDISMLKERVELLQRQWEELCHQVSLRRQQVSERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENK-----IQLQEMGERLAKASHESKASEIQYKLSRVKDRWQHLLDLMAARVKKLKETLVAVQQLDKNMGSLRTWLAHMESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLEVSERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLRQMVHGGNQRWDDLQKRVTSILRRLKHFISQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPVRLPDDHDLS--DRELDLEDSTALSDLRWQDPSADGMPSPQPSSNPSLSLPQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAS-RTLPSEDEEGEEDKEFYLRG-AVGLS-----------------------GDPSSLESQMRQLDKALDDSRFQIQQTAN-ILRSKTPTGPDLDTSYKGYMKLLGECSGSIDSVRRLEHKLAEEE-SFPGFVNLNS--TETQTAGVIDRWELLQAQAMSKELRMKQNLQKWQQFNSDLNNIWAWLGETEEELDRLQHLALSTDIHTIESHIKKLKELQKAVDHRKAIILSINLCSSEFTQA--DSKESHDLQDRLSQMNGRWDRVCSLLEDWRGLLQDALMQCQEFHEMSHALLLMLENIDRRKNEIVPIDSTLDPETLQDHHKQLMQIKQELLKSQLRVASLQDMSRQLLVNAEGSDCLEAKEKVHVIGNRLKLLLKEVSHHIKDLEKLLDMSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKSPRGKCSLSQPGPSVSSPKSRSTRD-GSDSSRSDPRPERVG------RAFLFRILRAALPFQLLLLLLIGLTCLVPMSEKDYSCALSNNFARSFHPMLRYTNGPPPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NF91-1", "uniprot_id": "SYNE1_HUMAN", "id": "Q8NF91-1", "name": "Nesprin-1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK-------IKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQS-LSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANS----------VQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGS-------VEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMN-VKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDP-EELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP-QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPV----RDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKN-----SLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA--QQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSS-LESLSSELEQTKEFSKRTESIAVQAEN---LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKE-KELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVT-TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRV-KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT-IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFS--LVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNET-----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESS-DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR----------------FRKAFRDFQQWLVNAKITTAKCFDIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLY-DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ------------HAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIP---QAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK-IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGEALLELVQDVTLKDK------------------------------------------------------------------------------------------------------------------IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLS----RAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQA----------------------------------------------------QNLTQGWEEIKHLKSELWIYLQDADQQLQNMKR--RHSELELNIAQNMVSQVKDFVKKLQS----------------KQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD-------YHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER-KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHE-RKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQN-EVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP-AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN-LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFH-SNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP--GSSAEKAS-KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTP---GEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTILPSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE--QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM--------------------------------------------------------------------------------------------------------------------------------ESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQ---------------------EAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG---------LAEGTEDLDG---ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP---------GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSE--SCEADPAEQLALQSTLTVLAERMSTIRMKASG--------------------------------------------------------------------------------------------------------------------------------KRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHN-ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQG---------------------------------------------------TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQK-----------------------------------------------------------------------SLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDG-----------------------------------------------------------------------------------------------------VSATSTWLDDVEERLFVATALLPEETETCLFN---------QEILAKDIKEMSEEMDKNKNLFS--QAFPENG------------------------------------------------------------------------------------------------------------------------------------------------------------------DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK--------------------------------------ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------------------------------------------PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETG-----------------------------------------------------------QEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGS-LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELG----YRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK---KKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK-----IQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP-LPDDEHDLS--DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRG-AVGLS-----------------------GDHSALESQIRQLGKALDDSRFQIQQTEN-IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS--TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA--DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKG-GSDSSLSEPGPGRSG------RGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z1N5-1", "uniprot_id": "A0A8M6Z1N5_DANRE", "id": "A0A8M6Z1N5-1", "name": "Nesprin-1", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASLSPFGRSSKDIMNLMQKLQDEQESVQKRTFTKWINSHLAKHKPPFEVNDLFEDIKDGVKLLALLEVLSGQRLPCEQGRQLKRIHWVSNIGTALKFLEGRK-------IKLVNINATDIADGRPSIVLGLMWTIILYFQIEELTSNLPALQA-LSSSASSVDSMASSETGSPPMKRKVVTKFQGNAKRALLRWVQNTATKRLGIEVKDFGASWRSGVAFHSVIHAIRPELVDMDVVRKRSNRENLEEAFSVAENELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDPHQSETDGQQEELVRSIPTFALSIPALQYDPQDIELMLEREERKVLREVKIWLDQLERDVLRAQGSEESLTDKYQAFKSFRVQYEMRKKQIESLLQPVHRDGKLSVDQAVVKQSWDHVSVRLLDWHIHLDKSLPGPLGVIGAWLHRAELSLREDVPIQQAHEETANIIHRKLEQHKEVLKNLEGHRQTFQQIHRDRSVNGVPVPPEQLQDMAERFNFVTTSSHVHLIKFEFWEMKYRLMAFLMLAESKLKSWIIKYGRRDSVELLLQNYIVFIEGHKFFEQYETTFRTLKQAADTYLKSGTSDGKITKRAEEVEGVNKFLSDATAQWKNLSVEVRSVRSMLEEVICNWEKYSSTVASLQAWLEDAEKMLNQSESDKREFFRNLPHWIQQHMDMNDAGNFLIETCDETVSRELKQQLLLLNGRWRELFVKVKHYARADEVDKLRKDYDDGIEALKAFIDTANERMNTPVQVSFLN-IRTYLQDVEDIKHKVPSMEAAYKTATRNAQQLTKDLSEDEIAHMLNNMTNIKDELSKIRERALPLLRDSQAMLPPLEEMEKNITGFYQSLEKASRITSSRDSEAPG--DFTQKCQELVTYQQSCKKCLSVIDKNHQVILKSLDTSKNLKHLDTSLLERRITELQASSQGMVKETTEWKQHVEANSSLMKRFEESRVELEKVLKIARSSMTERGNP-EDLLKKHTEFFGQLDQRVLNAFLKACDELTDILPEQEQQNLQETVRKLHKQWKDVQTEFPYHLLHLKVDLEKSRLMTSLQECQAELARENRSLP-SVGSERLIKEHRMFFKEKGPQALCEKRLQHMDELCLKLPESQQA----QQTLVIARTAFAEVKEEIDSTHQRLMQHPDKWKEFNTRFSELSAWVTSKESQLRLLRNRAGDPSKFGQVKSTIESLRNDAELQEGNVSWLKNRLAALIEICTESDAQRQGAALSKLSNDFKGLLISLSESEKVVLAVSDCVQFREEVKT-----TLEELTQGQKELQSDNSKILDSESVREAQQLLLLHQQQLKRLRLKRKDMQEQINRGKQLQIEEGLEESLQDDLQKLESTLKKMDENTESQEKNLEVTLSAWQEFDAQQASVREFVGKVRSVTEREMNFSS-PESLSSELEQTKDLLKQCETEVRQVNT---LLKRATEIQLGPKNQSLLQDQARALSEQVDKVEKGLKRDVKTLEGMKSQWDLFGSEFEAFSSWIMERE-REMDALKSSSIPLDQQICTVQTIRDGLQERSEVLSNLEEKSQSLVQFVS-SGESARIKARLTQIGRYWEELKESVDHLSGQLEESSSHQTKFNSNLQQVQSEVEEIQKKLDNPVTSCISSSETYKTLQSHMDVFQSLEKLKATLLSLSAGARRLSEREKAERAVAALQQNYEQCLKQAKEKQNQTESLLSHWQKYEKDWSALKSCLERCEAACGPDSQSLPVDKL-KLDGELLELKHLQTELESLEVVYNRLGAQTPSLYTTASDERVKTLKEDHQQLEKRWMCQTTAIPHRIQVLQQHLSQVDQFDQALQKFFKWGESFLSSLHSSSHTDITDLQPSTNDIKEKREALLKQSIVRQNLQQQTKTLCDVCEPAEVQHLQGRWESSLQPYLEAHQLVELRGESLEKLEAFLHTHSVAAGVLQGLRQTVESAGSWDKSRVEELQRELEAIVPDISRLETLAVNLDGNLCKSHLHLMSGK-ETRSSCRSLADSLSAELDAVRNLLGSKQSEAEALGALWSSFRQRKEQLLKTVEDIEEKADQQGLKEPNVLTLQQRLRFFNQLEDELQSHQHEEQWLRDKGQQLAHRDAELGSEVLREINLLQTTWEDTKKLITERQEQSSALVDLMKDYQTLKSSINSILESADAIADIKSV-LKDQEDTRRSLLKHEAVKADMASHQDVLDRFSSKGKKLLSELNKIPDCDTQ--IVKTEIDATVDQWLDVSEKIEDNLESLKRSSALWVEIYDINGEIESWSNSSVMDLTDGLNNFNDSQKTAHKLSEVKVDVGLKEKKIDALQEKVSEMKQLCGGQDVPAKLQVMETDLRRKLNSIEELCDQAKNNLQDFCCQKKQLEDFLSQMSEWLMSVERSLVDSPCGTA-----PEEICRVKEIQKELQNQQASIDSARESLNTLCRKYPSEELAGLGSSLTDLIKKYETVNQICVKRLGSMQHGLQQHFNDLVKEFHTWLSGQKDIVRECA-DHSGDMSVVERKLQKLKGALERVEDGDDRLTLVCTEGEKLLLHLPKASAGQVQQSLSSIQQDWDSYVEQCRQNQQNLEDSASLLSGFDGRLQRLSRWLERMDVKMST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELP--EGRHGDQERVTLERVEEFQHEVLKERDSFEGLCQEAQALSEGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGSGSEVRASAQLQHQHQSLLKAARERLRVCQLSMQEQQNFQETLQSTWLWLSSAQERLTALNSTGGNKETLEKRLALVQDILLMKGEGEVKLNMTVGKGEQVLKNCSRDKQEVIRSQLKSLKDSWANILMTAMSCHSRLEWTVAQWSSFQESKAQLQQWLEMVEQEAGVALPQQPGLKEKAALLERLRVIQADVEVHSTALSRLNEKATELYEKTGDQAFAERPKSDFNTQFTNITAVIKSKVQQMEEIVKEHEQYMESVRDLNDWLTSAKEELQRWSDMSGDAASVQRKLSKVRGLLDSRKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRERLTRVQSCGAATRDHTSTVGCEVLEREEAGLLSAWEQWERGAKHVCSGLEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLAQMANSEQEFNSLAAQLEQDLQEFSSKLQEWRIKLQQVEEMSAGEEAVQGWQIAKDTLEALQNVEPMSDNLKCQLNDLCRFSRDLGAQSERVSALIKEYNSLSLQASRECQGKEKLLEQR----------------FRAAFRDFQQWLVNAKINTAKCFDVP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNLAEASSSLQKIQEFLSDREQGQGKLNTVAASGELLMSIAAKDRVESVRAKINSAREDWKTLMTNLHQRENALQNLQAQMRDFETSVEPLQDWLNDTEEAVQESSSRLQ-DLTAKKQELHRLQSLLEELASKEPQLLRLREKAQQLWDGHTAGKGFVHRVSQLSAQYLALSNLTKEKASRIERVVSEHQLFSQGLKELQNWVSDTSHMLQTYCTPTADKNVLDSRMIKLEALLTARQEKEIQLKMLLTRGESVQRNTSADGVPLVRQQIEDLKDSWDGLLSASIQCKSQLEGALSQWTSYQEDVRQFVSWMETVEETLSSADKQ------------CSEMRDKTTNLGKAKLLLEDVLSHNSVLDVISMKGSNMAEHYVTQLEIQDLQERYNIVKDKAQCAVAKAEELVSAHQEYQHSLHEFKDWLDQQQERLSCYTQLEGDTETLEDTLRKLQELQVHCTEGQALLNTLLVSREQVIPWGVP---QLEDRCLEGVQQEWSSYQSRLTDTRSQLNSALAKLRQIEQKFQRLDNWLKGMESKGQLRTGRRSDRATKEAQLQLLKGWHEEVLVYQEEIEGLSVLAQQVLEETPISSRVSTRATQLTSRYHALLLHLLDTIKQLKEEVSCIEESQSVFCTFSDWLSTAQKNFSSVTTTNIDVVDRAAMEKKMKKLEALQGDMELGHTFLKTMREKTDRAMMFLEEPEAEQLKEEVDSRLSQLETLIRALRSEISATEKSIQLSKDFLDKYKTQTQWLSETKSLLASPVEPKAELYQKKAQLAKYKTIQQTIQSHESAVKSVIE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGDALLETIRDPSISEN------------------------------------------------------------------------------------------------------------------IGKLKTDYQDLCADAKVHVQSLTESVREHEDYNSELQEVEKWLLQMSGRLVTSDSMQSGNLEMATQQLARHKAIMEEIAGFEERLSSLKDKGDHLVSSCTEQVQAKISQQIQAHQQGTRDSYSAICSTAQRVYQSLDRELQKHVSHQDTLQQCQTWLSSVKEEIQMQPQTPYG----LQEALKQVKHFRALQEQASTYLDLVCSVCDLSDESVRATAAKIQQTKTMIEERMSTS----------------------------------------------------QELSDSWREIKEQKQELSTLFQDMEQQLQSLSR--RPAELETKIAQNMLDQAREFGQQLQN----------------RQSTLTKMTELVSKLTEGKESPEHTEIGRLSHAWLELCHQANKLQTQREEDLQRTKE-------YHDCISAMEALFEQVSKEWDNLARTDAESSSDHLEALRKLSVVLKDK-KSTLEDLKEQKQKVMYHLNLDDKELVKEQIGHFEQRWAHLESLIERKIQDSILTLEDMGQVEACLREAREWAEEQQPTLSEAMKMSPPPELAQSFLFDHLSICSELEAKQLLLAQAMGDADRVLAHLGLNERQRLQQLISETQAEVECLSVKVAQRRKHLSKAFTERTQFLLAVNQAITWVQQNE-KKAQAEEYIALLPDDLSKQVRTCRNIQSSLRAYQS-ELTSLWSQGRDLMKDASEEEKTEMLHKLQELQSIFEVALQKCSQRLQDLEKVLVTRKYFKADLEKICQWLKQADIVTFPEINLMNGDAELCSQLTKYQQILDQAMEFENLLLTVQRTGQEILPTLNEVDHCYLDEKLIALPQQYNNILGLAKEKQEKIQQAILARQEYASFIDVTHKALKELEEQFHSLGTQPIGLKTEEVVSLQADYKALLEELTNLGQAVGELNQKKEGFRSTGQPWMPEEMTQLVSLYNGLKRLIEQRVEHLDDTLESFEDHQAMAMQVDSELKATKEQLVKVNAETQS-AEERLKNYHALAASLQGASSHLTRLMEQMDNLVSHMDTAAHEVSKQRVTSWQEELRSLQSSVGELIVECENRFVQSKDFETEVNRTLTWLQQIKDELGSEVVVDVK-VEKVQEEIRKQQIMQEEVQSRLRIVAALSTREKQKYTSANELVPAHVDSSLQEMAKLEADVQRALSSKQITLEQALVLCQKYHSRMQAACEWLEDAVGFLQQASLGVDVENYEECLRQQEDIMATEQEFL-GVLEELESLPPQLENLVNPTAKEQLRLSVESAQQRGVEVRDQLQCHQDVLNSCVAQWNSYQEARQTVIDLMNEVEKKLTEFSTAKAATNQEAEEKLRSHKSLVSMVNSFQEKLTGLEEQASQLEQIGSDASKATISRSMTTVWQRWTRLRSVARGQERVLEDTAHEWRTFREKMMKVRSLTEEVKGRVP--DCTAEKAS-KATLQSHLDQYELVSQDLERELSSLTLLRQYALSLLHDVEVSVPTADHEQLPSLKEIKAVQDQLESLLQKARAGKSRVQQELSDREGVERGLSLVKSWIQDSRELLLNPTSDLDILSQELEVMHGELITHRQNVDK---LAEQQQSKYLDLYTILPSEISMQLAEVSLALGSIEDQVQARERDIQKSRVIKEEFNSRIHDVSEKMKAVSTALKEKATDIDQAKDEARRLCDELDCCGRTLAELEAAVQDFGR--RNPLIARQLADAIAKLREIHHHTLRLADYKTIWLKKADAHLDEYNEMFEFIVKWTDRARSLVKANIIWNSSSHLQEQIRMYQAVLRESRELHGDLDSMQEKVEILSETLQVEAMGQQVSELSRHTEELEQSIRSRLQSLQDAAKDMEKFESEVKVLHVSLDQVQATLTSPELARLSLKEQLAQRQRLLADM--------------------------------------------------------------------------------------------------------------------------------ESFKQQVEAVQECQSALRVPEEVVTSLSICRTALNLQQEASQLQHTAIQQCNILQ---------------------EAVVQYEQYEQEVKNLQVMIEDAHRVIQDQPVNTSNIQELQAQINHHEELAQKIKGYQEQIASLNSKCKMLTVKAKHATTLLTVSEAEG---------LTESLEELDG---ELIKRKSQ--AQVSMSAGRSQSLLSPVTEESGEEG-ASEICSPAFCPSPS-STNTEAVIS--------------KMSMGRSSLTRAPVQELYNPALES--VASLDDLQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WETLKNVISEKQKTLYEALEKQQRYQGSLQSISSKMESIETRLNEPPMH---------DLSPDRQMILHQNQMEEIIRLQDDIHELQSSFTEELYNPD-SVDSDSADQLAMQSSLTVLAERMATIHMKASG--------------------------------------------------------------------------------------------------------------------------------KRQILEERQSERVEKQQQAQALQHYLNQADQLDQWLKSTHGYITSCS----QDSDAEEQLTDCQNMLLEMEEKVLALSELSRHS-ESLLLEGRPENREDAEQLARKLRTLKGSLLELQRMLQDKQINLQATLI-----------------------------------WEELKGPQRASDSLQEASDSSESDSTLSQSPNMQDWLAQARTTRSLQHQDTLQKQKELEEQLAEQK-----------------------------------------------------------------------KLLKSVASRGEEILTQQASPVRAS----ATETLSPDVELEGDSEAVKKQRRKRWESLKKDMTTKLQLLMNTLEQDSKQPFYSRTACVKTAAPVYKRETHVQDKSNLMSLHNGFSQTIQEMTPQA--TEREVILMEQQLYSA-----------------------------------------------------------------------------------------------------VTATSSWVDDVENTLFSGPALLTENADTQLSN---------HETLGKEVTEVTQEVGHTQGLIK--GSVGLSE------------------------------------------------------------------------------------------------------------------------------------------------------------------DEQSLMKDTLDCLTRRLGALDSALDRRCDSMR--------------------------------------SRMRELSAFQTELQRLFTALSESKFQIIQKMAGVLDHTTTKQIETIAEAEETLKDFEHRITELKARGAELQPDQ------------------------------------------FSTNELLKLQDAYEELVMTVGSRRSGLNQNMALKNQYERVLQDLIDLVDTA-----------------------------------------------------------QDKMTADQKMIAASVEDVHNLLDKHKEFFQGLEWHMVLTETFYKKSSAFVLPRERQTLEETLARAQDVLKQAHKKGVELECVSETWSRLVLDYQTLYRLLEVVEGSLPSVGLVEETEERLNERIQLYQALRSSLTEHQHKLHQVLEEGKHLLSYVSCSSLENQLTVLGEHWLNNTTKVNKELQNLQSMLKHLTRYKSESGELSRWLLEALERLEFWNTQFVAGPQELETVKGQLSAFLEFSKEVEARSNLKASVLNEGNQLLRLKKMDTASLRAELACLDSQWSELLSRIPIVQEKLHQSQMDKLASRHAITELVNWISLMERVIEEDEENLKGAVGSKVIQEYLQRYKGFRVDVNCKQLTVDFVNQSVLQISGADVESKRSDKTDFAEKLGAMNCHWQILQTRITERVQYLEGLLTSWVEYEGKVQGLQAWLDAQEERLKRKHRIENLSSVQNALKDCQEMEVMVKEKERELERVEEQACALVQNKTDEACAVVME-SLRALNNTWANLDHLIGQLKISLKSVQDKWNQYKQASEEINGYLTEGRYSVSRYRLLTGS-LEASRLQVESLQNLQEELEKQESSMRKFGSVTLQLLEECHPSVSDTLNNTLKDINARWSSLQEEIVERLKSSKALLQLWQSYKDLYGQSDSSVQTLEEKANQMLKTASHKDITEEEVSAWIQDCAELLRSQAPVQASLQVLMELGEQLKQQVDTSAVASIQSDHLSLTQRLSVVEQSLSRQQVALQAGVRDYETFNEQLDSLSRWIVEAEEVLKGQDPNGSSDQSLIQDRMEDLKKQMLKFSSMAPDLERLNELG----YRLPLNDSEIKRMQNLNRSWSTTSAQTTERFCKLQALLLQQQTFLEKCETWMEFLVQTEEKLAVEISGNFQSLMEQQRAHELFQAEMFSRQQILHSIISDGQHMLEQGQVDDRDEFKLKLALLSNQWQGVVRRAQQRRGIIDSLLRQWQRYREMVEKLRKWLLEVNHQTQSLQAGTPVPLQQARAMLDAVQLREKVLLRQQGSYILTVEAGRQLLLSADSRAEAVLQEELLNIQERWRNANIRLDEQK---KELAVLLRDWERCEKGIGGSLEKLRAFKRQLSQPLPDRHEELQAEQMRCKDLDSMFDGWKEDLTHLTVLRESLSSYISLDDLRVLQERIELLHRQWEEICHQLSLRRQQVSEKMNEWAIFNNKYKELCEWLTQMESKVSHNGDVSIEEMIEKLRKDYQEEVSAAQENK-----LELQHLGERLARASHETKASDIEHKLSKVNERWQHLLDLIGARVKKLRETLVAVQQLDKNMNSLRSWLAHIETELSRPIVYDTCDYQEIQRKLDLQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRSLDRRWRSICAMSMERRIRIEETWRLWQKFLDDYSHFEEWLMLSEKTAALPNSSGVLYTIAKEELKKFETFQRHVHESLTQLELINKQYQRLARENRTDAACSLREMAHNANQRWDNLQRRVSSVLRRLKHFISQREEFETARDCILVWLTEMDLQLTNIEHFSECDVQAKIKQLRAFQQEITLNTGKIDHIFLQGEALLEKSEPIDAAVIEEELEELQRYCQEVFGRVERYYKKLIRLP-LTDDEHDVSFSDREFDLDEAADVSSFPWSERLGDGFLSPLPSS----SRSAPLRAERSGRDTPASVDSIPLEWDHDYDLSRGLESAS-RALSSSETGDQAEDDGYLQGSASALSDVVIPESPEAFLKLTEQTLRSSAGDAGSLETHIRQLDKALNTSCFHLQQTEN-IIRSRTPTGPELDATYMGYMRLLEECRGSIDAVKRVGFELKDEDDKISGFVNPNS--SESQTSGVIERWELLQAQALSKEMRMKQNMQQWQQFNSDLSSICSWLDQTEEELQQERGLDLGTDIQTIELRIKKLKELQKALDKRKAIVLSINLCSAEFVQS--DSEEARELQRRLKEMNNRWEKLSSSLDEWRTALQHALMQCQDFHEMSHGLLLWLENIDRRRNEIVPIDHTQDSDTLQEHHKTLLQIRRELLDTQVKVASLQDMSLQLLVHSEGSDCLEAKEKVHVIGNRLKLLLKGVTRDIRELQKTLDISSSQQDLSSWSSADDLDTSGSLSPVSGRSTPSRQRPPRGKSSVSEPGACVSSLLHSRSLN-AAGSAFSHSEDEERPS---WCRSFLKRVFWAALPLQIILLLVLIVACLVPTSEDGYSCAQLNNFARSFHPMLSYTNGPPPI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PC75-1", "uniprot_id": "A0A8M9PC75_DANRE", "id": "A0A8M9PC75-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEVKGKVARRWEDVAAKKKSGNSLNLVQGVSQHLRDEQEAVQKRTFTKWINSHLAKRNPPLVVSDLFEDVKDGVMLLALLEVLSGHKLPCEQGRKLRRIHWVANVGRALKFLEGRRSAYRGSPIKLVNINTTDVVDGRPSIVLGLIWTIILYFQIEELTSHLPALQP-QSSSNSSVESSNSTETSSPPVKRKPRLSFQGGAKRALLKWVQNTATKRMGLDVKDFGPSWRTGVAFHAVIFALRPHLVNMERVWRRGNRENLEEAFSLAERELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHHPDRQHTETGQQQEEFYLAPRAIEEML--------------EKEQRKTLRELKAWADQMERDCAQAQRDGGSLTVRYQTFKRFRVQFEVQRRQVETCVQSTQKDGKLTADQALVKQAWERLCKRLLDWHLQLDSGLPHPLGEVGVWLHQAEEILREELIPQQAHDETAKAIHKKRLRDQEILRLLERHKQTLQLIHRDRCVNNMPIPTEQLQDMAERLHYISTSSHIHLSKLEFWESKYSMLAFLTLAESKLKSWIIKYGRLESMELLLQSYGTFVEGQQFFEKYESSHQSLLQAAELYIKADSS---------VEGVVKLFLREVCDQWRSLSVEVRSVRSMLEEVQCNWLRYNSCVASLQAWLEDAQGALRQPENTKREFFRNLPHWMDQHAAMNDAGNFLIETCDETVTRDVKHQLLLLNGRWRELFLKVKQYARLPETHNVR-----IHQDIQEFLDASINKLTSPLQVSLLD-VKAFMQDVEEIKHKLPAVEAQYKAAARSAQLLAKVHGG--GNKARSTIPTTEAHLHQLKEKCPLTLKECQALFPLLEELEKQISAFYQTAEDAGHIITQQHN--------QEMCQELQTQQQTCKRCVCAIERSYLALQRALCCAKSLHNFDTSLLQNRVTEIQTTAQALMQEALEWRQVAETNGSLMRRFEESRADLEKALRVGQACLKERGDP-DELFRKHNEFFGRLDQHILSAYLKACDDLTDIISEEDQKSLRDTVRRLHKQWKDIQAEAPAHLLRLRVETERRFVMATLQDCRVELKREDKALP-AAGSEKIIKEHRAYFRQKTPLSACEKRLKTMKHFCQELPENDRG----YQMLEGAKDHLLEVKGLVDQTHLRLQQHPDKWREWHVRFSKLSEWLISTQN---------------GAENSSVQMQRRAIKAQSETLDWLKARLAVLEEISPESEAHMQRDALEKLSQQFFAALLSLSEAAGVAN--EASVKTEEELK--------EEVNDDDLIQIQEHRQILNAESATEAKQLLLIHQQNLKTQQGKDMDVRCQGNFFK---------------------------EDRAAQEKHLQVTVSSWQEFEAEREAIWQFICHVSPVLQRELIFSS-LDNLKSERNNIQELHEQGYMFAVRAES---LVKKAADIKLGPQNQSMLQDQAQSTKERLQEIQDSLRKIVTDLEMTHRWWQSFNRESEAFFSWVCDSK-SDLEASAQTSATLDEQIHSVQMLKEGLEEKMDIFSQLETEFKTFINFIT-PNETGRIQARLMQIGRYQEEFKNNMDQRETELQSSLKHTKQFAQDLAEVESLLKGLLEKLNVSITSCTSASTTYKTLHEHMDAAQRLQQLGPRLMSLSLGWRRLPDAGQLEETVAELQKSHKLHTQQATEKQSKLENLLTLWQRYERDLSLLQSWSNRCESLCNSDSPYLTTDHV-KLHSQLEMLQDMQSEVPSQESLLESLETRAESLYSSATEERTAELRDLHCNLEERWCSLSTNIPLRIQELQSHLAQLEQFSEVSLALTQWSENFLRHIQTTCKVSISDLQSADSKTKEDKTSLQTQGRSLEALQPHLDALSPSLAPKDLQHLQTRKEDCIQLFNEAQSLVEHRDQALLKLKDFYESYNKAKDSLQTIQQAVQERGSWDDSKVRDINQELAELAEELASLEVQAISLDIILNKAHFHL-QGSEEERVSCRGLVDDVAMSVQVLQRSIGTKQSEAEALASMWSSFRGRKELLIESLAKLEDRANISWPTETNSQAFQQRLWLLKQLEEELEALQHSQLWLRERGTQLALRDPELAEEAQRDVTLVQSAWERIRRIVAEDHDLCANLLELCRDYQTLKTRIISVVERAHAITVSQSD-PHNPDDIQRALSRLEAVRPELAATKEDLNKLIGSGRCLTDVLKKLPEESIQSENVSAEMDAIVDQWLDISEKMDADINLYTHSLELWNDINKMANEIECWTAVSVSELSEGSVGLLSSLDMQERLSDFKLELDNKEDELKILQAKMTELQELLKTQHTHTELQVMATDLRKQISHAAEVYEQTRGMCEDFSSQRQQLQDLISQISEQLKTSEDSLAEFSTSSD-----PENFAKIKEVERSQKQLEVSLDLAGESLRALCRTYPTQHLTLIGDAISNLVKRSEEVTQRRSQILGLLQEALLQRFNEKAHAFHGWLSELRAEAEVCF-EQTGDAVAIFSKQEKLKTVLEEVAEGEKRLACVCVDGERLLLHLSKGGTGGVQEQLDSCQNALDMFVLECRQRLQSLEESAGLLNAYEARVVELSDWLQQLELRLKTDA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLWGESEPAAPDCSEELTRVEEIHRELLMRRASLERLCQSSVTVRERE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRAEN--SAAEEMLLNHEALLQEARTRLR----SLQDYQAFEEALRAVETWLKDVEIKLEKLESTEGNKKEVEEKLEQAQDILLMKGEGEVKLNMAAGKAELVIKTNGEVERGVICSKLQEAEDAWAALLLGAMSCHSRLEWTVSQWDLFVESRAQLQRWLEGVGLEVKGPLEPQLGLREKRKQLERLRLLSSDVEDHQGALCYLEESAAELYKRTGDPVFKEEEMVLLRAHFEDVKAAAEERVRLSEDVVHEHKTYMETTRELTDWLMVVGEELQQCSDPSGDSPTLSRKLTDVRELLERGACE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRERLRRVRLSAERAGRHTAAAGCELMDGEVAALARALHQWEGASLRARDALET---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVAAATGAEREQTRLTAQLEGEMEKLEGQLKEWSDGLSCAERRNSGAAAVEGWTLAKGVLEGLQTAEVMEEKLKAQLNELCGFSSDLGPQSDRVSALIKLHNSLSLRASRECQNKEKLLEQR----------------FRSSLHDFRQWLVNANISTAKCFDSP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSIQDASIALQRIQEFMSDKEQGQTRLSAVLTYGEQLSSVLAAERVEAIRTKANTAKDDWKSLMDSLQRRETALQVLQSQMQDFEASIEPLQDWLNRTEISVQESSARLH-DLPAKRLELSKLQTLLEEMRSRESELAGLRGRAHGLWDGQGAGKSFVHRVCQLAACYLALSNLIKEKVSRVERVVGEHQLFSQGLQELQNWVSESQQVLKTCRCPTSDKTVLITRMGQLEALLAACQGKEIQLKMLITRGESVQRNTSAEGVPVVRKQIQDLKDSWESLLSTSIQCKSQLEGALSHWTSYQEDVSQFECWMERVEESLGNSDKH------------YAEMRDKTANLGRAKLLYEEVLSHSSPLETIATKGSNMTEHTATQQEIQKLSERYTTIKDKAKAAVSKAEELVLLHQEYQRGLHMFEDWLEQEQSNLAVLSPLDEDVNALEDTLKELQMLQSHCPKGHNLLSSVLSSRERVIPWGAP---QIEDRALETAKTEWQGYQDRLAETKVQVEQALARVQQLEGLFQSLDQWLVDMELKVKVRSHRRSDVTAKETQLQHLKRWQTEAACRQAEVEGLSTLAQQVVEDAHVSGRISTRVTQLTARYHALLLQIQETLKQLQEEMQKITEAQNALRTFSDWLSTASKNFKIITER-TEALDRITMEKKMKRLESLQGEMDQAHSLLKTLRESAELAVSFLDDPGASRLEREVQTGRSQLEELILGLREEHVTLERSIVLYKDFQERYKGQMQWLRETRALLSSTVEPKVELYQRKAQLAKYKAVEQTLLSRDSAVSFVVE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGETLLTLLHSPSITDN------------------------------------------------------------------------------------------------------------------MSRLQADYQELRGTARTHVQRLEAQVKKQEAYHKDLQEIERWLLQMSSRMVTPEPSSSGGLEAATQQLARHKAIMEEIAGFEERLATLKEKGEELLSGCSERLQPRLRQQIQNHQQGAKDSYSAICSTAQRVYQSLDRELQKHVSVRDTLQQCQTWLSNVQEEVQLPEHAPQC----LQEALTQMKQDRTLQEQASTYLQLVCSTCDLSDEKVQETAAEIQQVKLQIEERMLES----------------------------------------------------QELTDNWREIKDLRSNLECHLLEAEQLLQNMLR--RPAELEPKVAQNQLDQAQDFIQEMRA----------------RQVDLTHLRERINRLTAGQESPELMEVGRLRCSWLDLGRQAAQLLEQKEEDLQRSGD-------YHDCICMVEELFDQLSKKWDQLARGDIESTAECLDALKKLSTDLQDQ-RCVLDDLRNNRHGILPRLSLEDRDLVKEQVGYLEQRWTQVESLVQQKIQDSALTLEELSQIEDRLREAQEWAELQQPSLSEALKTSPPPDLAQSFLFDHLSFCAELEAKEKLLAEAMTDASSLSSRLGLNERRKLQTLVEEAQVEVASLGTKAAQYRKSLSKVFTERTQFLQALDRAAEWIKKQE-QRALADDHVALLPNVLHKQVAACKNFTSSLRAYQV-ELTSLWVQGRDLVKDSTEEEKKETLHKLEELQVIFEASLQKSAEHLHHLEKALVIRKYFQMDLDRICEWLKQAEEATFPVIDLSGNDVNLQNQLAQYQQLLDHASEYENLLLIVQRAGQEILPTLNEVDHCYLDEKLNGLPQQYNDMLLLIREKRDWIQQVLLERREFESLIDITRKALKELQEKSDGLEMQSANQSLEEGERLHRSYEDLLKGLGNLFQGMKDLRCKTQDFLSMGQPYAHEVTGQLVYLHSSLNKQIECKIKVLRKTLKVLNDHRAAIEKMDCKITRLKEQLDRLESDIEADAMERLSTLYDLSKCLKEASTHSEGLKAQNDDLNQHFD---LETLKTQVIFREEQLITLKQRINKHREKCERDLKGCKDFQIEG--FFDWLKSLRDQLRRPLMFDEANVEIVQQEASSLSALQEEMKSRFRVLEDISNEEKQKYIHDQKSFPKLFETTLMDIPKLKEDLQQAFNTKQVALQSALSLFQRYHHSLQCIQQWFDDAGALLEQVLLEPDLEKISDHLKDLEDTTGREHAVR-LMIDEMQDLIPQMGDHLSPTVIKHICQHCDESHHKATEVFEQLKQHQDNLQRSITQWRSFQDETDDVIRQMNDIEKRMKELTTAKANSEQEAEDNLHLYQRIMPQVQGLEDALNCLKEKAAQFDQP---AIKDVTSQSVRSVSHRWSRMNSVARAQVKTLQDSAHNWRCIREKLEKMRAVCEDLHSRVP--DSMVEKASSMAALHSLLEYHDSFSREVERESSALTLLRHHVLNLFLHPHTTAPTILNSEKPSLLEIQSIQDKYDILLQQVCASRQQVQMELLEREEVVRELGLLKGWIQDTQGLLLSPTADLDNLLTDLEAAHGGMLSHRQNLEQ---IVDRQQMKYQDLHTILPSEINTQLAEVTLALSSAEDQVQAREREVQHSRGIKEDFNSRLKDMSKKVKLISLKLKQKAVDVEEAKEETETLFEELEECARALSELDVAVQEFGE--QNPLLAKQLSFSLSKLTELHAQTSRLAEERTTCLQKAERNFEEFNEMLTLTLNWTEKAETVVSTNLMWSPLSQMQEQIRTHQALLQEWQDLQGEFEGLVERVALLGEVVQTEMLHQQVSELSRHAEELQQGAKTRLLTLQDAAKDLTRLENDVKSLHQSIERVQETLASPDLARLSLREQLAQRQLLLSEM--------------------------------------------------------------------------------------------------------------------------------EGLKQQVQAMQMCQSALRLPEDVMAALPLCVTAQSLQHESSQLQHNTIQQCNILQ---------------------EALVQYEQYEQEVKNLQRLIEEAHRVIQDRPVATGNIQELQTQIQHHEELALKIKGYQEQISALNSKCKMLTVKAKHATMLLTVSEVDG---------LSDGLEELEDEEDEMPKHPPTHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEVSSPPACRSPSPGPNADTSQG-----------------SGRAPLSRAPLQELYDPSMESAASANLDDLQRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WETLKNVISEKQKSLYEALERQQHYQETLQSVSTKMESIETALNEGLEP---------SKSPESQMAAHQALMDEILMLQDEISALQACFSQELQLDEDSLEADAGDQLALQSTLTVLGERMATIHMKASG--------------------------------------------------------------------------------------------------------------------------------KRQLLEERLNEQLEEQRQEQALQRYHSEAEELDNWLLSTRATLSSTLQPHPQDMDMEEQLIDCQNMLLEIEQKVLCLSELSVHS-ESLLLEGKAGTRGDAEQLSLKLHSLKSSLLELQRILQDKQTHIQG---------------------------------------------------SLQEQEDTESDSSLSQSPNMMDWLSQARSTRNQQHQDTVQRQRELEEQLGEQK-----------------------------------------------------------------------KLLQSVASRGEEILSQRTTPNGEN---CPAEFPNGEDGQWPACMSTKDQMRVRWENLSKDLKNKLQLSLNTMEQTPCNALYQP---VSSPCGVFRGEQLSQDIPSPRSLFEGFNQDLEDLPQTGGTDSKRSRDLQKALYQA-----------------------------------------------------------------------------------------------------VSSASTWLDNAENELASGPVLLSDDSEAHLVH---------LEGLNKEVKNVNEEVCKCRDVLGGRERLWVEG------------------------------------------------------------------------------------------------------------------------------------------------------------------RESDVVEEVFDGLEGRLKLLDTVLEQQCDGMK--------------------------------------DKLQELTVFQTELRLLLTALNDSKYQLLQKMNAAMDRPASKQLEILAEAEDSLREFEQKVSEIRSRGETLQPNQ------------------------------------------ICTQELLKLQDAYEELVEMVGSKRSGLNQSLVLKAQYERALQDLVDLVDTA-----------------------------------------------------------QDKMAADQKMKVGSVIEVQILLDKHKEFFQGLETHVVLTQAFFRQISGLVVQREVQSLEETVAQAQAVLKQAHKRGVELEGILEWWSRLVGDYQALYRQLETVESSIPSVGLVEETEDRLSDRIALYQRLKASLSERQQQLYKLLEDGKRLVLHVSCSELESQLTQLGDHWLSTTTKINKELHRLDSTLKHWIRYQSESAELSQWLSSALDRLEFWSTQSVTVPQELETVRDHLHAFLEFSKEVDAKTSLRASVQSQGNQLLRLKKVDTAALRANLAKVDTQWADLLTRIPVVQEKLHQLQMEKLPSRHAITELMSWISLMENVIQEDQQKIMGAVGSVVVQMYLQKYKGFQIDLSCKQLTVDFVNQSVLQISNQDVEGKRSDKTDFAERLGAMNRRWQILQGLVTEKIQVLEGLLESWLEYENMVQTLKTWFSVQEEKVKKKHRIEDVSSAQNALKDCQEMEVLVKEKEKELEKAEEKGCLLIQDKKGEAGSFIMD-TLKNLNQSWANLDHMIGQQTVSLRSVLEQWSLYKQAYEEIQGYLMEGRYTISCLHLLTGS-PEAVQVQVENLQSLQDELEKQESSLRKLGSITQQLLKECHQSVSDSLNTALGDVNLRWNTLLEQISDQLRRSKSLLQLWQHYKALHAQCSADIHKLEEQVEHLLKSATHRDITQQEVKG-------LMATEGSVESVLQQLDEFSEQLRQQVDPSAMTTFHTEHLSLTQRLAAVGHALQRQQSLIEVSTRDYERFSKELNSLSRWAEEAEKVLKEQDPVGSPEISFVQDHMDKLKTQLLKLSSLSPDLERLNELG----YQLPLNDNEIKRLQNLNRSWSSNSARTIERFSKLQALVLQRQTFLEKCDAWMSFLTQTEEKLAAEISGNYQSLLDQQREHELFQAEMFSRQQVLNSIVNDGHELLNQGQVKDRDDFGLKLALLSNQWQGVVRRAQQRRGIIDSLVRQWQRYTELIGKLRHWLHEVSLEPEDQQQGTTVALQQIRGMLDHIQLKERILQRQQGSYILTVEAGRQLLLWADARAEASLHTELTDVQERWRAINIRLDERK---KELLSLLRDWDQCEKGITASHEKLRDFKQKLSVPLPDHHEELHTEQIRCKELEASIEGWADDVAGLCILRESLSSGLSADDLTVLHERLILLQRQWEETCHQLCLRRQQVSERLNEWAVFNEKNKELCEWLTHMESKVSQNGDVSIEEMIEKLTKDCQEEISVVEENK-----CQLEQMGERLAQASHESKAAEIQYKLCKVNERWQHLLDLIAARVKKLRETLVAVQQLDKNMSSLRSWLAHIETELSRPIVYETCDSHEIQRKLNQQQDLQRDIEKHSTGVASVLNLCEVLLHDCDACATETECESIQQATRGLDRRWRNICAIAMERRLKIEETWRLWQKFLDDYSRFEEWLKVSERTAALPNSSGVLYIVAKEELKKFEAFQRQVQEFLTQLELINKQYRRLARENRTDSSCHLRQMVHDGNRRWDILQRRVAAILRRLKHFIGQREEFETARDVILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFKQEISLNNTKVESVFGQGEVLMEKTEPLDAAVIEEELDELQRYCREVFGRVDRYYRKLTRLP-LTDDECEGS--DHEFESDD---LSDLQWGEDGAIQQASSRPSS----AANAPARTNGSGRDTPASVDSIPLEWDHDYDLEPMSHTMS-----AERVRQKDEDEDLLCMATAALTDVVIPESPEAYIKLTEN------TLRSSSGEAVRLLDTMLDSSRYSLQQTDG-SMDAH-------DTSYMGYMRLMDDCRGSLNMVKRVEGELEEDEENLSGLSNPDN--TETQSTGVIERWELIQAQSGDLEHRQTEDLLLWQQITSDLEDMEAWLEEAEAELAELRGRDLSADIHTIEQRIRRLKDLQKAMDSHKSKVLSINLNSVTLVQS--DSDESKVLKAKLKEMNSRWDQLGKSLKDWRTALQDALMQCQEFHELSHGLLLWLENIDRRRNEIIPIASGLDRHTLRAHHRALKQIQRELTETEQKVDGLQELSGQLLVQAHGNECLEAQERVHVIANRLRLLLKAVETDLEMLEKELQDSGNRQDASLWSVTDETETSGSVSPVSEVSVSTKRQSLRGKCSVSDPGSSSRLRRHRLARGSGCDSSRSGSSGSQGGVAVVRCQPFLLRVLRAALPLQLLLLLIVGLTCLVPMTEQDYSCTLANNFARSFHPMLRYTNGPPPV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9MRD1-1", "uniprot_id": "MS300_DROME", "id": "M9MRD1-1", "name": "Muscle-specific protein 300 kDa", "aln": "MADSGGPGSKHMDPTTIDAGGGGAGAAGGDDVPPVPAVRRRRAHEQKSSREQVLEEEKSQQLETSTVTRTYMKTITTSLTTSSSSNVEEFILGEHAAGAAAAPSPNQQRLRQKVAQYEKVWSDGSSPVKRPAEQSSDELRLTDDQDEYDAENPFEIDVHEIERRLRQERQRGLAEAEAAKLAFQQVQLRHTTPPRRVEVTSDQVASPFNVTLRTTSRMSPGAEHGNVEEHLAPFNVTLRTTRRTKKKEFKELENFLEGERTVREVPSADGVRTIITSSMTSDGGYAEEKIYRHGEGYVSPRDSPSWSRSSYSSERSSVTPPRSVDLTAGGRRILIKLEQESELTEENQTRDETDLSFGRQEVAMATGNIDITVGGSNPRRRLYQQTTVQVGGGNRTSPQDSTPQRPRDLDLAGTTKTMLTSTPIGTKEQPQTGPKTLVSPAATCQLRGSSTEEPRKIVSHKTITSTTTKSTSSSTSATSSSSTSRKLIETSPVVVGKIAQIRTGKSNASDNDIDIDNDSDTEGRPASSIVIVSTPTRPTTPATASVSASAVTPSASISATAAHALSGIGTFSKSLRQDYQTLATQSGRSNESPSDQEYQEFQSTMASINYARSNSQYDSHIKEKREEQERVQKKTFTNWINSYLLKRVPPLRIDDLINDLRDGTKLIALLEVLSGERLPVEKGRVLRRPHFLSNANTALQFLASKR-------IKLVNINPADLVDGRPPVVLGLIWTIILYFQIEENSRNLEYLGHGIGGSVSSLDSVGNQKHG-----DLKAEKWKQGARKTLLNWVTNALPKDSGVEVKDFGASWRDGVAFLALIDAIKANLVNLAELKKTSNRQRLETAFDVAESKLGIAKLLDAEDVDVPKPDEKSIMTYVAQFLHKYPEPKGASRDQSHVQQEADELRR------------------FLVEKTTEYEPMVMMSSFPRDFGEYLLARSEVDAHLAAYNRLKQLIESQSGFLQVSRQ----------SWEEINELWQRLQYQMMYWLWLLDSELPGDFGTVGKWLAEAEKLLMDNDIPNAMNEETAAVISRKLEEHKLFFADLPRILAMFDNAK--RSPVAQQIPLEQLRNMERRLQEVGPKAAERRIRLKFLEHKCCLIAFLNLVENKMRGWTGKYGHEEKVAQQLEQYKNFVSRNKIFQEFQKAFVDMQQVVEEYKRDGNVP------RKEINDIDRFMYETEERWKRVSMELKCCQNSLEEVVNCWRSWNQLAPTCEEWLQLAEQKVNQSEDERLDFFQDIPVWKDKFDALASSANYLIASCEEPIAQQLRQRHGALSERFERLFANTKQYMHAGDIIRSRQEYKSGIEQLSRWLRGAESVLDQRQVLGNSEQVKEYGQQLQQLASEIDDNEELFKTISRNFQSLIQDLSRDEVDKMMKLLKQEKESLVRIRAQLPAKLHLFHQLQIQQESLEAGQKEIHQWLSEAEQLLG-THNLSGGRDAINEQLHKHKTYFSRTVYYRSMLESKNKVFQNLLKAVSSDDKIDTAPASQQMQQLNERFNYVIQNAQQWEQRLDSAAGGWSNFKDNERVVSEWLTQAESMLVEKHIESKTTIETQKYFFEQVNDRWMNDLVQSAQQLLTTLPAQEQPAVVHSVEQLQSRWKNVLSQAPLHLLKLEFRLDENAFYQSLKDVEKELQLEQQALNRNEDVDSILQRNQQFLLQQDVVPRLERCLQNMQRLAQAHRQQQPGDISLDQAYDNAKSQWQLLSNKLGDMRQTLQQIPAQWQGYHLKFNDMVDWMNGVDQSLKNIVNEVNTMEEFEKEKVVFQKICQDADNKREDMKWLVKTLDSLLSYATEDEANLEQKKLEDLIARYKNLIPTIEITMVKTEVFSKCYTYRREVHEVVCLLS---------KVKDQTANIPAPDSLDRVNRLIEEQQYAINQLDHQRPHIMSMLQRGRDLIKDVHAPAFVNAEVKNLETGWNQAYTETSDKLQALKGTQAVWSEFVDQKNDIFSMLQTAETELRSLTPLQTDPKNVSQDLKSKRDLNVQLQQASHQLLPKLHALKSELAPLAAPDKRPILEKEVTEVEKMFFNTMEHVKDRVGYLEDYSAKWNNYKTRLAELQEWANKVAPKNIEALQSEDLTPEERVVKVQAFKRILGDRMKQLDLLAADASELAPKEGNIAEAKRLKGEITKLQEVLSAINRNVDHQAQAVQEDLVNWQQFQAGLQQIKPAVEQSEVKVNNVVSKPISLEEAVAMQQNAQQFETQCQEQLDKLHGISNISHKMLCKTNAPDELDAMHSRWTAVHENAKQASAKLEKLVANWKSFDADAAKLEDWVGQGEQQMSRRPAVLNTPHIDKLEKELVKLKSFNNEISQQQAKLVTLGQNADQISLHLAPEGAAALKDRVNQMKGKLQKLSEATRGHINEVSDAIISRQDFNAKLVNFSNWMEQLRNQVTQVEEINPERVETSLHVIHALLQEHADKKPSFNAIYDEVKQLALGATPEESNALNDAYTALVVNYQNLETNMLQKKAALEKWTELLGWKNDTESHLNYLKHQLDKPEGPAAEELSKVIDEIDNLGQGIGYWKGQAKEID---ENPAIQLRDALSRRPLIATQIVNDVENKLENLKLRSQSQQQQIQQMTVRKDKFHALEHNFGQALQENRAKLDEILRQHPTLNNIDQIIADLVALNDALKYQADLKNRIHDEGSLLMREDIASMPAIQESLLIMDKNYDSLQNEIADRIQKYNLISQALREYADSKDKFSKELKKAEDLYNAIPQQPRDETELHQASEKTRKTMEQLRKSKLSLDELERRGNNVGKLFSAIGEPIPQ--EVPQEVTAAKQHWQDLHDKTAKNAHVYETEAVIWSQIEDAKKDLLPWLSETNQGLCDAADNSIEIEFGPMRLSKYRTELPSYQALKDSIVEKTNDLVKINKGAEIP-ALSALNKLLSEQFAEVNNNADRLSAITTSFNDQEQELRRRSKEAGERVSKLREQLIKCDDMSGDNNKIMERLQQCRALRGELDNSGNEIDNIKQKVDELRNLYPTFSESIIPKELNNVQKRYENVDLYAKKIESSLLQFLKKFHADKVGMLKRIIATQREKVAWCQPESSSDKYNLDVKKSSLQEVSKSIDDCKARHAETLKSLEMLKAVESPQNLAELTSDAELLRKDMQALQDSFDQIKGILDENVDLWSQYEQSNEQISNWLRDVEGRVKAETSSQVNLSEVPQKLQELSILQQDVLAHEPIINNLEQTSQQLIEKNPEARIGQFVTHLVQRYQAVSKALTSYIDKIRGAQLSNANFAKAAKDFNEWFGDAKIEFQELARMGSPGSSSATAQQLQTVKNYIKTFDNGQILLNNAVDIGEALYPVVSPDNRERIRADLRQMREKFDYLRDEANAFMQQVEGVLIQKTSIEESYTQVSHYLNESKAKVPTTDELYPTLATKKAALQNYKTQLQEITLHKNALKQLHDKAVTLCDDESERKTDESIQEYNTLSKKISDRITTVGNHVVKHEAYDQVLEKAQDWLNTIKSEAIDILNETTFEKEGAEEKLLVVENLLQHKPEGDSIFDTCHKLLETVLTQTHPSGHPALLKGFEEPKQSWEDFMTLCQDSLVKLKQLCSKWDEFDTIIEELDNWMKNVEAVVKNQNLKSTAEAKNAHLKQLQDISKDIERRGAAINELMDQGREIEGETDLNLKLSRLNTRYQTLKNLCKESIAKYVNYVKDHESFDKDFDSFKQNLQSSVDELAKTNEIVGDQSVLQDQQNKLREMSDKRILDSTLFEGLIDRGEKLYGHTSPEGREIIRQQLRALRTLWDNYTDDLNSATQKIDQCLLQFNEFSIAQDQLTKWLKDVDKAMQSHTEPKTTLQEKRAQLQNHKLLHQEITTHNVLVDNVCDKAQILVDQIKDNSLN-VYLTSIKQLFQSIVQKSDEILHNLDDCVQKHNELNNALSSAKTWISNEKAKLLECDDAYGEKADIKRKIETLGQLAQNKPQAMKIISDIRDLFEKVKATTSEKGNEVLDKEIEELETTMKSHFDDIEGIEGKQKDVLAQWDKFEKALEELTKWCRSAEAVFREQQLQSTLHEKVEQLEKYKIQRELILQKEKEIDAFGDAAHALLNNCGADRLKTLTTQITNRYQLLQVLSKEVVNRWSNLVDDHQFYQDKYNEVDLWLQPIESQMAKVLLDEPTQSSNILQVLLSEKEQAESLFAALNAAGEKALPETSTQGREKIRKDLRDIRDRWDKLDEGIRNLEKRQEAQGVQLSSYQDILNQTVNWLDQVEKLIHNENPASWTSAQEIRSKLYKYKATNQDINSHKRIVEAVNEKAAALLGSAAPANADEISKAVAEVNKRYDQVGQDCAKLVADLDGAFDVYQQFSELQKAQQDYQKNLWDRLTGYSDYSGNKAALQARLQKINEIQDALPEGVAKLKSLEDHIEQQASNIPARSKEVMARDLANLHADFEKFGASLSDVKSGLENRLQQWNDYEINLDRLITWLGEAENSLKNYNLKSSFEEKEEQLNGFQSLAQNLRQNEADFDKVKDDTSELVQSSGETRIAVNVQQVSSRFQSIQATAKEILKKCEQAVQDHGHFNDKYKQCADWLANAQARYDDCCDLSTVASRDDLLKKQVVIQELLAQQPTATQLLNSTVELGEKCYGSTATEGREAIRSQLDDLTFDQLFDNIAITARKIQDKIAKWSGFDEIADSLKSWLDETENALPADIELKTTLDEKRNKLQTYRDILNDINNHQVELGNLQEIAANLPEKTELVDQIIKDISDRFGKLQKRAQNYVERYEGIVSAHQQYSKAVMDAQEFIDATLNTVHYWGDLDLEQISLHTNLDRLKNLKASLADEFPRVDQVRALGEKVIPGTVDVGQVNIKSQIDTTQQEWESLLTTISSTIEAIEARLQHWSEYEQLRDQCLAWIRDTDNNLHAIDLKEDLPKKRAQLDALKALQGDVRAKELEVDNVTEKAQTLLKGPSSNRASGPELVTKYQQIFHKVKELNNRWQQYVTSHEDFDNAISDC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PTSSAVTIEEVGSPTEELVVPITPGPDNLSGEPHNIWFSATTSVDKTPIELSQALIMSESLQHYPGQQKLTQEPILISTKEAIGDRIKQLKQASPQQATPLSNVLHLATLSEQIKELPTEQRILEVNEGLKDLDVAIKNGDKTVIQTTVITVIEKVSTWLETIEYRVYLIRQNSNEGPSEEKLDNYNQLNDELSTIKQNVVQLERQLSKAEPEPQLLQCVDSLKEHVDAVEQVTQQNQVQDSNDLDKWHNFEVLLYNVSSVLADLQQSYDLLINQEYPLSAKLAQLDELEQQHEAAQQQLAHLCQNARAFQRDFPGKKMPQDVHNAFETSKNIANNIQAERERVLQLQSLAEEYEQTLKEFTKITVLADKLVESPIVSSSLEQLNNEVQKQRKFFVNLSHCRAMLESLEENIDSETREKHSELHKELYNRATSLLDKASERSSKLVQAASRWTVLEKGMRDELQWLQVAQQRVPDLSAVTSAD--YDQYTTLYQSLSNDISHHYVKMTQLSGIANKLQLLVQAPNLVEETNEALIVLLKLREEVALYLHRLLVFKEIWVQYEQQTDKLEAFVREAEQELRNIQIPSQPTHQPIEHMRQFWEIKARFELHNNVRTDTGLSFEKS---LQVIPLADEMLQRQFHAQLEDRWQAVAQAIELIQHNIVECLSSEDVPADEKLKMVERELQEIYLTMTSMKGVIKNE--EELCLYIERVQVLRTRVGFIGNELGRIGLQEPAIEPEKVGELFSLSHKISTQIAEELEGASVLR----DQLQAIQEGISNQRKHQAKISVILDECEAAER--------QGADVLEKAVADCQAAGEELVISWQEIMRIRQMLHTLPMRLKMSVSPVKLERDISQLQDDHAFLESKCTNIMAILRSRLAVWLRYERQLELVHGSVQETDFMMELIRVHGQVDYERLRKATERLEGLAGDLHNREQLIDELKGAAKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYRNASAAVKNSIDQQMDAVKSLEQPLDALQHAKVCQDN-----------LTTQNDRILELRDIVAKIAADVGLDASALMQGELDALGQRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPKES---EEQLAALRAHLQTLARTEEQLRQLKERHQNSEVAPSVASSDDDGILEVLALWQKIFQDTFQEYHRLSTRLARSQNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLES-------------ELSEQYKALTNLHNETLSRIMQRNGELERRVSGWNAYRQQLAALLDWLRQREAER-NALQLRYIHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQQELARHCDDALATAMRMEQASIGQRISNLRAALKTWQGFLQRVTQLSESYEQRVNQLQQEFGAAQKLLDANSESLPTQPAAIEQLLGSLRAQRVQLGAQVSALESLTVTQEELKECISPHDMKTIRQRNWLLWQQHADLDYQLANLINSIEERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAKQLEQQVNSELQLRDKEREWLLSTSRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAWLFEVESQLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGEVLNLVEMLLNDADSWRTQVNTSGLAASAQNLEQRWKNVCSQSAERKARILTIWNLLQQLIKLTAEHKNWLGKQE-----------------SQIAGFERDQKSHSKHKLEERQMELRAKLEELESQSVNLRQLEQIYAKLAMSAGVEPENIQKLTLPTKVMVSMWRQLTPRCHALLDAIDKDAKLMREFNNAQLEATNSLNAIQKALEQLPSAEN-------QQTSKAEPKAVLQRLESLEKKLQDAQQHVQQADNLAQEAKTRTKQQP-------------QLKQLLELVSAYTTLWQT------------------VQTRIVTLKTTWLTRAAQAAASLPVSEAANAAVQVNTLSQRKLRQAQQMQRETS-------------------------------------ITAKDAYIMELQTAITECQNNLDELQRTVVDKTRKPGPQKIAKLLGNAQSSTELVKHLSHLLLTECKADDQAAEVDTVAELTLRFDTLQSQWKARQQHDQNASEVGRLTCPLCTQRNWQQIDNDLWRLEQWLQFAESTQKAQSAP--PSNIELLEDVTQDHREFLLDLESHKSIISSLNVVGDHLATHTLDTEKARQLRSRLEADNERWNNVCINATKWQGLLQTALMGNSEFHQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKKFKDLRAELERCEPRVVSLQDAADQLLRSVEGSEQQSQHTYERTLSR-----LTDLRLRLQSLRRLSGIYIVKLGAVLGYEGDNLG-----VPLHMLSSELLDNTTLSTSSMQAAAPNTENANNTDGGDAVDGDVINTTVLARGAR-------FLGRVARASLPIQALMLLLLGVATLVPHG-EDYTCMFSNTFARSLEPMLSYPHGPPPT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ... . :. ::*** ***:***:****:* *: **: :.**::*::** *:********.:** *:*: :* * ::* . **:** .:: *******.:*:.****.:****:*********** : :* * ..* **::* . : . : .*:::**.** : * *::***** *** *:** ::* *::..**:: : .**:.** ** :** :***.:***.***** *************** ::*: : : . .. :: * ..: ** . .: : ::: :: * : :: * . ::: *::: ::: * **. ** :* :* ** .** * :: : ::*** * :* ..: .: :. *. :* :**.:* .*:: : ..: : :::* * * ::::* *.*.*::.* ***: :.: *:.* *:. ::*:::: :. : *..: * : : *: :. :*: :*:*::. :. **** * :.. ..: : **: *: : *.* : :**:::* * ::. : .:.*:** :*:* :::::::: *. *:..** :.*:* : : . : : : : : :. : :: *:::: .: : :* ::. : : : . : : * ::: * : : *.:* . ::: . .: . : :: : . :: . . : . . * : ..:: ::: : ::::: :*.: :: . .*::.. :.: * .. : *: . :. :. ** ::::: :. :::.::* :. ::* : .:*.:*:.:**:: : * ***:*.. :. . :::: . ** * : . : :::.:: :: :: *: *: :..:. : : .: : :.. * : * :* : :*..: *: . : : . : :.** * * . ..*.:*: . * .* : : :. . .. :: .: * ... ..:::: :* : : .: . : : :: : *..* :: : : . . . :.: ..:..: :. ::: : : :* .* :: :*: :. .: . . :. : :* *: : . : * . ::.: . : :: :: : : . . * . : *: *::..: :: . . :.. : : :* .* ::. :. :: :. * : :. : :. : :* :: . ::. ..*.: . *.*:: *: : : : : * : . : *:. :* :: ::.*: . * : : : . :: ::. : . :: :.. : . :*. : * : : : . . : : : : : . * . : : *: . : : : : :* : : * ::: :: . .. : :: : * :* :. :* . . . .:.: .:: :: ::*.: : : . *: .. : .:: . . : : .. ::: : : *:: *: . :::.. : .* ..: :: :: :. : : : : ::* * . . :: * : . :: : : : : . .: : *: : *. : . :. : . . * :: : ::* *: :: : . . * :: . :: * : : . . *.. . :: . : * .:: :: . *. : * .:: : : .* * ::. .: . . . .* * : : : :. . .. .: : : * . : : :..: *: * . : . : . * : . :: : : . . : :.* : : .*: . . : . : . . : * . . : .. .: : . : *:: .. . :: .:. *:. :: : .: : . : *: : ::. * : . : : . .: :: * . : : ::: : ::: : :. .* :. *.:. :: : ::: : ... :: .:.: . : * :*. . * . . :: : *:. : : ** :*:: * : *:** *:. : : : * : : .: * .: * : :. * .: .. :: :: *:.* :: . *: :* . .* *: . .:*: : * : * :* :. : .: . *:: : * .:: . . ** : :::* : :. :: : *: * : : : : * . . : **. .:: . ::. : :.. *:* .. ... ::::.: * : . .*: : : . * * . . . ::* : ::.. *: :. : ** : : : : : :: . : ::.:: : .::::: *: * : :: . * : :**. . *:: . .* :*. *. : :: ::..: : :: :. * * .. .. . ::: :*:: * . *: *: .::: :*. :. .::. ::*:::: :.: :..* .* * ::: *: : : :: :..** : :.* :* :. ::: :: * *:. .* *** * :*:.*... *: *: * .* . .: : : :: : * ::: : ::::*. . :: : * : : : .:.::: : .:*: * :: : :*. : * ** : :..* : * .: :.*: ** . .:* *.. * * . . * : :: : : ::. *: * .:: .: : : : :** * . . :.. *: * :: : :: :. ** ::: . *:. ***::*:*** : :: :: . . : .. ..* .: :::. : *:: :: * :: .:. *: * : .: * :..: . .::. * :.. . : ::: . * .*: : . : . * :* :::* * *:: ::: : .:: : : : :.: ** ::. . . : :*:: :.* :: * .: . : *: .**::*:****:* :: : : .. * :*: :*:*:: ** :: .* *: **: : : . :. : :. :***.:: .*: :: . * .* *. . .***:. :. : :: ..* : : :. : :: : * . *: : .: .: :: . * :: :: ..:..* . : : :*. : * : *: : ::: :: : * : : : :. : ... * :* : :* : : : :. *:: : :: :: . .. * * * . . : : *:.:: : . :::*: : :. * : :.** :::*: .: . :.:* * . : : : : : :*.: * : . . .* *. . :: : ***: * . : * * :: : : : . *. . :. . :..: : :* :: : . : * . : *:: :. . : :: :*.: *. :::* . :: *:*: :: ::.:.: : *:. * ** *: .:.. .**:: : .* : . * ** :*:.:*..: : .*: :. *: :**:*.:.*: *.:.: : ::. : :: : : :: * : : * ::: : : . . *: * :* : . : ::. . : : : * :: * . .:. :: : . :: . . :::. : :: . : :.: . : : :: : :* : . : . : : : .: * : **: . .* : ::.* . . .::: * :. . :. : .. . * : .* .: . : :: * . .* :*..:* *: * * : * . * . .::. : :. ..: . . : : : . *: :*..:*. : * :: .:: . . :: : *:. .. : ::::* .: : : .:. : : : . : *:: ...* : .: :..:. . ... :: ::: . : * : *.:: . . . . : : :: : : . :. :* : * * :. :: :: : * . : : :: :: :. . :* . ***:: ::: : * . :: : ::.:..: : :..: . : :: :: . * . : .*: : :.. * : . :: : : :* :. : : : .: .: :: .* .. . . .: . .. ::: : : :.. : .:. : :.: : .. . : ::: : .:. * **:*.:: : * .:: :: ::.: * *.: : .*::** : *::: ..:. :..:: ** *.: * * : :.:* : :::: ::: : : :*:*: *::: :. :: . : : * *::*:. ::* .:*. *:.: * .: : * :.. :. *: * :: . : : .: . ..:*:.* ** ... ..: * ..* .: : : .: :*.:*. * : :** ** :: : ::: : ::.:* :*. . :* : * : . . :* ::: ::* : : * : :.: :: .* .:. * :. . :: ** :.: :.* . :: : :.: . . : : : :::::* . :. : . .. * :::* :.* : :*. : :: * . :. : .:.. : . * : : : . . :::.. ::: : *::* ::: ::. * . * . . : .. * : : :. : . : : : *. : : . . : .* : . :: .. ::::* :.: : .. :. :::: : . : :: .. .:: : :.: . . : :: .. : *: *. . ::. : .: . . :. : * * :: : . . :::: : :: * :. : ::. : : . * .**: *: *: . : * * *: *:: . *:* .* :.. . :. : * ::: : *::::* .*. : : : .: . :. : : :* :*.:* ::. :* . *: * . : : *:. : :*.:. * . : : *** * .:.. :: : .::* :....* .: . * :: *:.* : :*:.:: * :: * :.* . * :* :: .*. . :.:: *. . * : * * : :: :* : * :*.:: : .: . . :::. : . . : : *::: : :: :. . :. . *. .* * . .:: ::. .:*: :::* :: : . ::: :. : *. . ::*: *** : . :*: : .: * .. :. : * : *: : * * :: : : . : * : :. :: : : .: *:.* :*.::* : :: . : *::.*. : : : .:: : *. *:: . : ::**: *: :. : .. : :. : :. . : : * :: :: :*. .* : :: : .: *:* .:: :. : : : :.: . : :.: :. : * . : :::: *: :: .:: :* :*:* .: ..: . : :: *. * :.: :*.: : : *. * * .:* :.: *: *. ::. * :**: :.* ::*:*.:* . :. :: : *:* : .: * **.* :: : *: * : * .** : . . : *:: : . :: : : : : . * ::* .* : :: * .: :: *. : :.: * ..::: . : . : : * .** : :. : . . : * : :: * :* .*: :.:* ** :* : :*:. :.: *::. : :. : ..:.:** ::*.:*.::.*: *: *: :::: : : *. * *: *. :::: : : :***:* * :..*: * ::: :*::.: :* ** .:*::* :*: ::: . *: **. ::::**.**:**:.*..**** *:**:*.*: *:.: ..: :::.*::**:.:*: : **: :* *.* *:::. :..::** .* .:: ** *: : : . :: : : *.:: *.:: . ..: : * ::. .:: . . :* : : : :::: . .:: :*::* : : * . *: :*::*:: ::: ::. . .:. : : * : : : * : : * *: : .* .. : .: . . : : * . : . ::: : :. * : : :. : : :: .. . : *. : . :*. . ***: .** : ** :* ::*. :: : ::: :: :*: : *:*: . :. *:.::: *: :*. * **:.: .*: ** *** . **: *: *:. ::. : *: : *. :. : ::: ** : :* .**: : *** .*.: . : :.:.. *. : :. *.: : . *: * * .. ...*:. ... . .. . . . ** *: *:**:* ::**:: :: ** ..*:* *.****:.*** *.:**** ", "identical_positions": 961, "similar_positions": 3008, "identity": "7.62%" }, { "cls_id": "homologset.agr.HGNC:1709", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P40241-1", "uniprot_id": "CD9_RAT", "id": "P40241-1", "name": "CD9 antigen", "aln": "----MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETN--HSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYK-DTYQKLR-NKDEPQRETLKAIHMALNCCGIAG-------------------------GVEQFISDICPKKQVLES-----------------FQVKSCPDAIDEVFHSKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR-----------RSREMV-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P40240-1", "uniprot_id": "CD9_MOUSE", "id": "P40240-1", "name": "CD9 antigen", "aln": "----MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENN--HSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYK-DTYQKLR-SKDEPQRETLKAIHMALDCCGIAG-------------------------PLEQFISDTCPKKQLLES-----------------FQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR-----------RSREMV-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P21926-1", "uniprot_id": "CD9_HUMAN", "id": "P21926-1", "name": "CD9 antigen", "aln": "----MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYK-DTYNKLK-TKDEPQRETLKAIHYALNCCGLAG-------------------------GVEQFISDICPKKDVLET-----------------FTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR-----------RNREMV-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QBC5-1", "uniprot_id": "E9QBC5_DANRE", "id": "E9QBC5-1", "name": "Tetraspanin", "aln": "---MAALTGGEMCVKYLMFVFNFIFWIAGTAVLAVGLWLRFDPKTKSLFEGENS--PYVFYTGVYILIAAGALMMVVGFFGCCGAIQESPCMLGLFFFFLLVIFAVEVAAGIWGFSNQTKVTEDITTFYR-QTYDTYQQSKQEALKKTLRLFQHGLNCCGPSG-------------------------NMQESLDETCPKKEGLDN-----------------LIIKSCPDAIDEVFNSKLHIIGGVGIATGVIMIFGMIFSMMLCCAIR-----------KTREIV-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q1L9G6-1", "uniprot_id": "Q1L9G6_DANRE", "id": "Q1L9G6-1", "name": "Tetraspanin", "aln": "MMSKSGLSSGEQCIKYIIFFFNFMLWLAGTGVLAVGLWLRFDAKTKEFFTAENG--QTVFLTGVYILIVAGAVMMVVGFLGCCGAIKESACMLGLFFMFLLVIFAAEVAAGIWGLSNKDKIVSDIQQFYT-QTVKNYKESPDGPLKETLTAIHFSLQCCGPTG-------------------------LVTDGVSVTCPKQEGLAN-----------------VITTGCSSVIQDMFNSRLHVIGGVGIGIGVIMVFGMIFSMLLCCAIR-----------RTRDIV-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KH03-1", "uniprot_id": "A0A0B4KH03_DROME", "id": "A0A0B4KH03-1", "name": "Tetraspanin", "aln": "----MGLNGCCSCVKYLMVLINILFWLIGLTIVVTSVWMLTDPTFMLSMTQNYN----HYHIALYVFLAIGILITLGAFFGCCGVCRESQCLLVSFFCVILIVMVAQIAAGAWAFHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNVDRTNIVEIAVSSMNVFYNIPESCCKDNLKDNECELSRRLKFGGPLNNAIYQQGCVDKLIEIIYENWVTIFAVTAAVILLELLSLTFALSLCCAVRNQHYKAXELQNSHREITDDEKY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.. *:**::. :*:::*: * ::. .:*: *. : : . : .:*::: * :: : .*:****. :** *:* ** .:*:::. ::**. *. :: :: . : .. . . . *: :: *.*** * : : * *.: . . * . : ::: .. * .* . :: ::.: *:: ****:* *::. ", "identical_positions": 43, "similar_positions": 88, "identity": "14.73%" }, { "cls_id": "homologset.agr.HGNC:17090", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M3AXD6-1", "uniprot_id": "A0A8M3AXD6_DANRE", "id": "A0A8M3AXD6-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDID--YYRSK-PLAEESNFQTTNYDAISIDECHYNVLRDDLESDARDFEAPTWSLAVDPQYLKNFSKDAVKRQDVIHELIQTEINHVRTLKIVLNVYIRELRNTLQMDETRLERLFPQVENLLEVHQFFLDNLKLRRLDSMEPGSSQNYCIHNLGDILITQFSGEIGSRLRYLYGMFCSRHTDAVNFYKDLMQNNKKFQNLIRKICQLSIVRRLGIPEIILLITQRITKYPVLFERVIKYTEDESEEQMDLIKGLDFLKDTIAQVNAHVDEAEKEARLRELSSKLEPKSQVKMTSGRVFRREDMLQGKRKLLHEGMLNWRVTNNKGKGDKHTDVIVLLLSDVLLLLLEKD--SRLTFASLDGKPAVISLLKLIVREAAHNE-KAMFLISASLDTPEMYEFHTSSAEERNTWTNKIWKAVECCPDVKE----EEPE------ELSKKIWEFQRKLCVHDASIEQHLTEKLKLFSSIAASVTGVSDTSTSERHPLRG-NAAEPLQGERLLTGALKDVENLQNLLVMCEQGPTPFT----SRATDLVLKKPHAVTGLENNTHMLPENG-FESSMESMGDRIQVAN-----TDLDPQLRELHLSENQELSADEN--------LSVHFPKAEFYSTVSQLSRKLYSLQSVVQQLESHIKVQHATIEELK-----SRPRG-NSLLEQEKHRNLHKQNEELANFQRLQNQRLQEQRQWEQERERQMLQAEAREKELREREMACSRQEEMLAGEKQELARCREEYQQDLERLRESMRSVEKEKEKLELQKKYKKNENVP---VVYPLENEQ-IQIPPPYP---ILN-----------------IVSPGFTERAPLVPPRRESITGSL-VKPEVPIHLISTTNQTLK-AGSVQQKIPTKLAAQPKG-KEKHSKHR----NSHQRTNSAAGIEVSHVVPIKVAGREGG-----SLKAIRSSSPHHLHPDLFTHP--DKLSSSVSSHSGNSS--RKHNHSHNSHTS-----STHSTHSGHRKTKDSPNAEDIFFF----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TGC8-1", "uniprot_id": "A0AB32TGC8_DANRE", "id": "A0AB32TGC8-1", "name": "", "aln": "MADPPLHNSWPSFSWMKRWSFKRASDCKPCTQVRIPVSAPSSSSSLSPASIPEDVFFSSSPEEKRNFLAESDECSSEEDLLDLCPSLRDSEYFRDLQLGSTEPPNTQPTALNAPNKSPTSLIPLLSTPESESDQDFTESDTQQLLQIDHTLISSMDRLIAVKTSESQDYPPSDQDEDSDMDTFPILVRSMSTSRRHSWECPVSPIDLGRRFSLDTAGIDSDGEREVQCLAKSSLLPSSSFSESSVEEATSAVESESPKTQRQQPSTPTKTIYSRSEILATDEKSQAERVSRILETSKQAAREAGEKHESEEGLQSGEGRSHVLMVQKVLQELKQYHGA-KRRNSSTDRKEVTGNFTWYEFLAHENDEEEEDRPERPERGTKVKRTLSSLRNRMTGSFNKDKGKNREKEQHKEKGREREKDREKELSERVKVRRRSVSGHQLVPGSFSSCATCTLCSKTLQRKHGLQCLNCAVNVHKSCKNLLPECKSKAKDSAQKTSNGAAQLNSQALRDPCTALTPIDGSSRLSRCSAGMTVPHKGPSAQPASSSNPSASQNSSSSGSITGEMDEID--AFRVRRPADDTVSLASTVPESLIVEDAHYATVRSELEALAQDFEVESWSLAVDQHFSKTHSKEAIKRQDVIYELIQTEIHHVRTLKIMLRVYARELREALQLDERRLDCLFPRLDSLLELHNHFLSRLRERRVESLQPGSERNYAINKLSDILISQFSGELGDRMKESYGDFCSRHTEAVNHYKEQLQSNKKFQNLMRKLSNLSIVRRLGVPECILLVTQRITKYPVLLERILHNTEAGTEEHEGLAQALGLIKDVIVQVDAQVSLYEKEARLREIASKMEPKSLGKIKDGRVFRKEDLSQGRRKLLFEGTVNWKAASG-----RLKDILALLLTDVLVLLQEKD--QRYVFSTVDNKPSVISLQKLIVREVAHEE-RAMFLICASSNEPEMYEIHTASKEDRNTWITHIRQAVESCPHTEERLFSEEEE------ARVARVREYQERLALKDAQITQSLAEKLQLFAELSECVAGLEDSGSRSRLLLRG-DTSDLQQGETLLKAAITEVENLQNLLTSRVRGTSAQTEGNQSPSLSLLPRRADTFGGYDSNSSALPKNGSIKKKGPGAGGRTRDRSQ---RASSDPQLKEVFTCQDHDELDEASSPASTNMWSSCKLPESELYERVLLLSQRLYSLQAIISQQDSHIELQRASILTAERERPGSRTRGTDVLLEQEKQRNLEKHREELANFQRLQSQHRQEQARWEREREKQRRLAEADQQRLKEREEECRRLETRLAEERLELERQRQTYQQDLERLRESTRAVEKEKERLEQQRKLKKHNTVPNTAALYTQELTQ-LSTSSSFNGEFLLGGAGEQTHPQKSLLRASLSASPADYPERPEVHSRRESSCNTLPAKTEVPIHLISTTNQLHK-QGSVQQQIPTKLAALSKG-KEKSGKGK----SSHR-TDSLASVDMKQMLPIKLSARDSDGGH-KTRRPISPHQPQHSHSDSLSPP--DAYSDAQSSLAPALP--KTHNQTSQQTLP-----YTVS---------DEAAKEDVIFF----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8I5ZLL3-1", "uniprot_id": "A0A8I5ZLL3_RAT", "id": "A0A8I5ZLL3-1", "name": "", "aln": "----------------------VGSEPKPYAQPLDSGTAASTTRGGHGPRKPENPDFFSTMEDEQADGFLRHLSESAEDLSLDLGALQGSEYLRDLGLGAPSDLH---------------------------------------------------------QSEVVMDPETP----RRESFHTSCEGASALPQRHSWERPRSCSERGRRLSLDAS--EVDEGACLPRTLASLALNLSGDGQKTWIQGCLPVSGTPAPSS-KEGNSPEKRLRSKSVPVSCEEISCLEPAS--GSDVCAPPVQGLEPPVLECLEKDHVEPDHVLIVQQVLQELRQYHGARQRARMSISPGGPHSNLTWFEFLS--ESEDGVCKNEKTDKSTRVKRSLSSLRSRVT----------------RQKEKGKNPAHLKDKIQDVPGKRECVNGHQLVRGTFSGHSSCPLCG-------------------------------------------KPLLSSASLKEHPRTALLSDGSSPAPSRNVGMTVSQKGGLQP-----TPSPAGSGVRLGPIAGDMDEADSVFLKLKQTADDSLSLTSSNAESVFIEDPYTASLRCEIESDAHEFEAESWSLSVDVAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLKIMLKVYSRALQEELQFSVQAVSRLFPCADDLLDMHSHFLARLKERRQEFLEEDSDRNYVIQKIGDVLVQQFSGETGERMKEKYGVFCSGHKDAVGHYKLLLQQSKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLSQALNLIKDIISQVDAKVSECEKDQRLKEIVAKMDSKSSGKLKNGRTFRKEDMLQ--RQLHLDSTLCWKSTSG-----RLKDVLAVLLTDVLLLLQEKD--QKYVFASVDSKPPVISLQKLIVREVANEE-KAMFLISASMQGPEMYEIYTSSKEDRNIWMAHIRRAVESCPDEEEGIFLEAEE-RRMAEARTMKLRDFQERLSLKDQLIAQSLLEKQQIYLEMAQ-LSGLDESAQCRGLFRGGGDPSETLRGEQILRSAMSEIEGIQSLICR-HVGSTSSQVE-EGGVSAGLPRRAETFGGYDS-VGSPNKGGSFKRKVYNSDPRPQDWQGPASSPDSMPCDTTTPSGCCEESPQAVEMPSAESSPCLPTVLESELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRMAIQEREKQFRLQSTRG-NLLLEQERQRNFEKQREERAGVEKLQNQLRQEQQRWERERARQQQELELAGARLQEREGEARQLRQRLDQERTELERQRQAYQHDLERLREAQRAVDRERERLELLRRFKKQNTVPGALPPEVLAEAQPASHPLNFNGDGLEGHLAPAKAPGTQG-SMLHGTGPEYGER-AEVARWDSAPAESRPAKSDVPIQLLSATNQIQR-QTAVQQQIPTKLAASTKGGKDKNSKSR----GSQRWESSASFDLKQQPLFNKLMGKDENAS--RNRRSLSPVLPAAHGSAPAPDPCFPAPSPVPAATAPEAF--KSGGTSLPPASP-----APS-LPTTPPTITDEVGKEDVIFF----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P9R4-4", "uniprot_id": "ARHGI_MOUSE", "id": "Q6P9R4-4", "name": "Rho guanine nucleotide exchange factor 18", "aln": "----------------------MGSEPKPYAQPLDSAAAASTTKGSCGPRKPENPDFFSTVEDEQEDGFLRHLSESTEDFSLDMGALQGSEYLRDLGLGAPSDLH---------------------------------------------------------QSEVIMDPETHRQEARRESSHTSCEGASALPQRRSWERSRSCSGSCRRLSLDAS--TVDKGACLPRTLASLALNLSGNGQKIWTQGCLPVSGTPAPSS-KECSSPEKRLRSKSVPVSC-EISCMELAS--DSDVCTSPVQGLEPPVLECLEKDHVEPEHVLIVQQVLQELRQYHGARQRARMSTSPGGAHSNLTWFEFLS--ESEDGACKIEKPGKSTRVKRSLSSLRSRVT----------------RQKEKGKSPAHLKDKTQDLPGKRECVNGHQLMRGTFSGHSSCPLCG-------------------------------------------EPLLNSASLKEHPRTTLLSDGSSPAPSRNVGMTISQKGGLQP-----TPSPAGSGVRLGPIAGDMDEADSVFLKLKQTADDSLSLTSSNAESVFIEDPYIASLRCEIESDAHEFEAESWSLSVDLAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLKIMLKVYSRALQEELQFSGQAVSRLFPCADDLLDMHSHFLARLKERRQEFLEEGSDRNYVIQKIGDVLVQQFSGETGERMKEKYAVFCSGHNDAVGQYKLLLQQSKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLSQALSLIKDIISQVDAKVSEYEKDQRLKEIAAKTDQKSSGKLKNGLTFRKEDMLQQ-RQLHLEGALCWKSTSG-----RLKDVLAVLLTDVLLLLQEKD--QKYVFASVDSKPPVISLQKLIVREVANEE-KAMFLISASMQGPEMYEMYTSSKEDRNIWMAHIRRAVESCPDEEEDVFSEAEE-KKIAEARTMKLQEFQERLSLKDQLIAQSLLEKQQIYLEMAQ-LSGLEESAQNRGLFRGGGDPSETLRGEQILRSAMSEIEGIQSLICQRHLGSTSSQVE-EGSVSAGLPRRAETFGGYDS-VGSPSKGGSFKRKVSNSDLRPQDWQGPASSPDSRPCDNSAPSGCCEESPQAVEMPSTES---LPTVLELELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRTAIQEREKQFRLQSTRG-NLLLEQERQRNFEKQREERAGVEKLQSQLRQEQQRWERERARQQQELELAGARLQEREGEARQMRQRLDQERTELERQRQAYQHDLERLREAQRAVDRERERLELLRRFKKQNTVPGALPPEVLAEAQPASHPPSFNGDGLEGHSAPAKAPGTQGSAMLHGTGPDNVER-PEVARWDSAPPESRPAKSDVPIQLLSATNQIQR-QTAVQQQIPTKLAASTKGGKEKGSKSR----GSQRWESSASFDLKQQLLLSKFIGKDESAS--RNRRSLSPVLPAAHGSAPASDPCFPAPSPAPAATPPEAF--KFGGTSLPPVSP-----ASS-LPTTPLATTDEVSKEDVIFF----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6ZSZ5-4", "uniprot_id": "ARHGI_HUMAN", "id": "Q6ZSZ5-4", "name": "Rho guanine nucleotide exchange factor 18", "aln": "------------------------------------------------------------MGDDQEDDFPRRLSESMEDLSLDLGALQGSEYLQDLGLGAPSHSQ---------------------------------------------------------PGETPDSRPTG-EEPGRDSLFSSLAGSQDLSRRRSWERSRSCSESWRRLSLDAS--AVDEEPCLPRTLASLALNLPGGGLKTWTQGCLSGGGTPAESPGKECDSPKKRGRSRSVPVSFYEIRSPEISP--GLEVPTPPVQGLEPPVLECMEKDHVEPDHVLIVQQVLQELRQYHGARQRACMSASPGGAHSNLTWFEFLS--ESEDGAGKNEKSDKSTSVKRRLSCLRSRVT----------------RQKEKGKSPAHLKDKGQDARERRECVNGHQLLQGTFSGPSSCPLCG-------------------------------------------KPFLSSASLKEHPRGTLLSDGS-PALSRNVGMTVSQKGGPQP-----TPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQ--RQLHLEGMLCWKTTSG-----RLKDILAILLTDVLLLLQEKD--QKYVFASVDSKPPVISLQKLIVREVANEE-KAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAE-MGGLEDLPQPRGLFRGG-DPSETLQGELILKSAMSEIEGIQSLICR-QLGSANGQAE-DGGSSTGPPRRAETFAGYDC-TNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIP-GSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRG-NLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPS---------GVGPEYAER-PEVARRDSAPTENRLAKSDVPIQLLSATNQFQR-QAAVQQQIPTKLAASTKGGKDKGGKSR----GSQRWESSASFDLKQQLLLNKLMGKDESTS--RNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALLPGPP-----APSPLPATPLSAKEDASKEDVIFF----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PBE1-1", "uniprot_id": "M9PBE1_DROME", "id": "M9PBE1-1", "name": "", "aln": "-----------------------------------------------------MDNAGEDSDNDVVTDFLNSNCSESSEALVNGGSTNRGASIESQNYCIP-----------------------------------------------------------------VINAPVPGPARAPIAPPPASNPASNTINNNNMIPTINVTPHSPALASKYNNIFEDTLSQLQNIRETVVQMKNSSSPSQHMQDGSLANHGLLSAAILSTSLPDLTGTGTGPASGGSNYAMWSSTAPQQCQFLHTDRRKSWTAVDDGSGAGDCTNKSVSLSSLDSEEQETIRVTEQRRRSARN---STGGISTHSLNEAELARDFERIAAKRSLATEIISRIPLQKSIST----------------SSIIAKEDIKAIARHLTDSEDENQSLLRAHAKIEVYDTVEKRPKRG--------------------------------------------SIFFRKKKPKAKTKSLVGGQLSACDVCGAAITLAQIK------------EHHLECKVKKMGGGQDYYDGPDASTFSNPEDQ-PLIRSDLQFLNEAPIEAQDLGADPVLGIVLKEHDSWTPNVPRELLKTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVFVESLERHFPSLN--LNSMFPRLQQLTDLHTCFLRQLRLKQRE--------QHMVDSIADILLDFFSLEQAQCLRLAYGEFCANHRSALDQFKLCLTEP-SFAEWYKHCLQNPLLKKKGIPECILFVTQRLTKYPLLIEPLLKSARDNKLETDKLQHALNLVKSLLVDVDACVAEKELRERQLEIYGRVDAKSFAIYKNKPFRKTELGVESRRRLKFDGLATLMQGRA-----KTQLVLVVVLTDCLCFLSENSGHNKYSFFTPEHKAGVVPLQKLLIREKAGTESRGIYIISSNPDFPEMYELKVQTPKDKNTWIQTIRQAVLDCP--ATDIIEAEDLTAEEKLRIGVNKRETIEKMRQKDIEQALLLEEKLMLQFNLLKEQQPFGDVAGTNSSCSAANFLAAFGSYKDLVSADCDTAELWRRVLNTVQDISQLASTIYSAATGQPVPRTLSSVGEKQSEQYASPTLPKRAETFAGFDEKRGKLAS---KLVLTPRLQELEEKREPKSG-----------SSSVSEQPLENNYAVLQVTHHLQTLLCVISQQMTTINNLQLQL----------------ALYRESPRSSAYTHKDQLEELRNLQDKQQEEKTAWQRQLKQQQ-------EELAEMRAQQLQLQKQIKAEQEDVRQQREQLYKKMELLSSQGLLLSPSTP----LPPVSNNHPPPAALLDDSHETDNGLSGS---------------------------GTGSSTPSVGGTFDRRKEKWLSGSSSCKTPPVNLISANNAPKVNPTLVKQKLPMKLSSLSSSGTSSSRVDKSASFNSASPTPYISAGSVQQMFPLKLADRRTATPSNCTTTPTTGMVPQHSRTGSSPAIIQQATTTATPTQTPVARAESVAHYTRTPTSSRTGIARTAGIAVATGTAPRAKPEEEEIYFXRQFTPEVEI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * : : . : : : : * :*: * *. . :***: ::*:: ** :* :** :: .*: . *.. : : :** :.* : * ** .*: :: : :: :..:.*:*: ** * .. :: *. **: * .*:. :* : . .* : :: : .:::: *: * **::***:****:*.* ::: :. . : * :.*.::*. : :*:* * * * *: .: : ** .. : * : *:* :. : ::.::*:* * :* *:. .: * : : *. *:.* **::** * * :.:::*.:. : *****: . : :::* * * :** ** . : .:: :* * ** : .: . : . : : :: . * : :: . . : :. : . . . : . * : ::: * .* .:: : : :: : : * .:. : . .:.:: ...**.: .*: *::: * .* * . : . : *: :: : *: :.:* * . :. . .::. * : . . ... . . *::*:*:.* *:*::* **:: ... ... : .* : .: . *. : . . * . . : . . : . . *: ::* ", "identical_positions": 126, "similar_positions": 267, "identity": "7.88%" }, { "cls_id": "homologset.agr.HGNC:17091", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CGU6-1", "uniprot_id": "NICA_RAT", "id": "Q8CGU6-1", "name": "Nicastrin", "aln": "MATARGGSGPDPGSRGLL-LLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDLKWVLTDGPNPPYMVLLEGKLFTRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKP-----INTSGGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAP-DVTTLPRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENID--SFVELGQVALRTSLELWMHTDPMSQKNESVKNQVEDLLVTLEQSGADTPQVVLSRLVQSQALPPSSLQRFLR-ARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPESQSPEEDLNFVTDTAKALAD--------VATVLARALYKLAGGTNFNNSIQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSYLDDGPLQHYIAVSSPTNTTYVVQYALAN--LTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTVRLARALSPAFELS--QWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFSLIVTYCINAKADVLFVAPREPGAVSY-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P57716-1", "uniprot_id": "NICA_MOUSE", "id": "P57716-1", "name": "Nicastrin", "aln": "MATTRGGSGPDPGSRGLL-LLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKP-----INTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAP-DVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENID--SFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLR-ARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALAN--------VATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALAN--LTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELS--QWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92542-1", "uniprot_id": "NICA_HUMAN", "id": "Q92542-1", "name": "Nicastrin", "aln": "MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKP-----INTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAP-DVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD--SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLR-ARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALAD--------VATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALAN--LTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELS--QWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VC27-1", "uniprot_id": "NICA_DROME", "id": "Q9VC27-1", "name": "Nicastrin", "aln": "---------MEMRLNAASIWLLILSYGATIAQGERTRDKMYEPIGG-ASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADLEFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGLNSTSETCDASNPAKN-WNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSLCAVEVKSFMSAAVNTEVCMRRTNFIN--NLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHTNEKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESYDYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTLDDISNIKLHALNGTTLAQQILERLNNYAKSPRYGFNLNIQS-EMSAHLPPTSAQSFLRRDPNFNALILNARP---TNKYYHSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTGTKVANPLMADEFLYCFLQSADCPLFKAASYPGSQ--LTNLPPMRYISVLGGSQESSGYTYRLLGYLLSQLQPDIHRDNCTDLP--------LHYFAGFN---------NIGECRLTTQNYSHALSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSRSEVLFEDLPASNAALFG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .. * : * :. *: .. *:* *:. *.*.* **.*** **.*: **..**:*::: * **:::*:. *.*** :: : ***: : :** .: .:.: : :.. . ** .::***: *: *.* : :: : ** *.** ::**.***: : * ::.. :::*:**.* : : . .***::: *.* *.:.* .****: : . .:. . ****.. **:: * * *. :..: :.::.: ***: ::* .*. ** .:: .*.. .* *:: :. :**:** *:**::*****.*:*****: :**.. . :* ::. : :*: : . : :. :: :*: : * . :* : : * ***:* * *** *:..::* :. *:**:**** *:*::.:*.: . :*. *.* . .: *::::. ***: *.::..: *:* . .:** ** *: . *:: . : * : * :**:* . :: : * * . *: :: :::* * . *: :: .: .: .* :* . ::****** :. :*** ****:** *.:: ***** .*: :. ** **: *::*: :.* *.::::*** ..*. : ", "identical_positions": 197, "similar_positions": 253, "identity": "26.95%" }, { "cls_id": "homologset.agr.HGNC:17094", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CQD0-1", "uniprot_id": "RL39L_MOUSE", "id": "Q9CQD0-1", "name": "Large ribosomal subunit protein eL39-like", "aln": "MASHKTFRIKRFLAKKQKQNRPIPQWIQMKTGNKIMYNSKRRHWRRTKLGL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q3ZB89-1", "uniprot_id": "Q3ZB89_RAT", "id": "Q3ZB89-1", "name": "", "aln": "MASHKTFRIKRFLAKKQKQNRPIPQWIQMKTGNKIMYNSKRRHWRRTKLGL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96EH5-1", "uniprot_id": "RL39L_HUMAN", "id": "Q96EH5-1", "name": "Ribosomal protein eL39-like 2", "aln": "MSSHKTFTIKRFLAKKQKQNRPIPQWIQMKPGSKIRYNSKRRHWRRTKLGL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P04650-1", "uniprot_id": "RL39_YEAST", "id": "P04650-1", "name": "Large ribosomal subunit protein eL39", "aln": "MAAQKSFRIKQKMAKAKKQNRPLPQWIRLRTNNTIRYNAKRRNWRRTKMNI", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "O16130-1", "uniprot_id": "RL39_DROME", "id": "O16130-1", "name": "Large ribosomal subunit protein eL39", "aln": "MAAHKSFRIKQKLAKKLKQNRSVPQWVRLRTGNTIRYNAKRRHWRRTKLKL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:::*:* **: :** ****.:***::::....* **:***:*****: :", "identical_positions": 25, "similar_positions": 20, "identity": "49.02%" }, { "cls_id": "homologset.agr.HGNC:17095", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZU78-1", "uniprot_id": "A0A8I5ZU78_RAT", "id": "A0A8I5ZU78-1", "name": "leucine--tRNA ligase", "aln": "MASACQRLSFCVSPLKRQLVSGLPVILWER-IIPGCSRSIYSATGKWTKEYTLQTRKDVEKWWHQQIKVQASKISEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALAD--LPEWYG-IKEMQAHWIGDCVGCHLDFTLKVDGQDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSLKTALQKALVPGR---------DCLTPVMAVNMLTLQEVPVVIMAKPDLEG--SLDSKIGIPSTSSEDTRLAQA--LGLPYSEVIETSPDGTERLS----------------------GSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQDLPVTLPSITSLTGRGGSPLASALEWVNCSCPRCKG-SAKRETDTMDTFVDSAWYYFRYTDPHNTHSPFSSALADFWMPVDLYIGGKEHAVMHLFYARFFSHFCHRQKMVKHR----EPFHKLLAQGLIKGQTFHLL-SGQCLKREDIDFTGP-----TPVCAKTKERLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTSGTAPQPQLLNNKEKAKARSLWEYKNAVITQVTTHFTEDFALNSVVSQLMGLSGALSQASQRLVLHSPEFEDALCALLVMAAPLAPHITSELWAGLALVPSKL---CDRYAWDAGVMLQAWPTVDSQF-----LQKPDMVQMAVLINNKACGKIPVP--QHVAQDQDKVHEFVLQSEL---------GIKLLQGRSIRKAFLSPRTALINFLVKE---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VDC0-1", "uniprot_id": "SYLM_MOUSE", "id": "Q8VDC0-1", "name": "Probable leucine--tRNA ligase, mitochondrial", "aln": "MASTCQRLSFYVSPLKRQLVSRPPVILWER-LIPGCSRSIYSATGKWTKEYTLQTRKDVEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALAD--LPEWYG-IKGMQAHWIGDCVGCHLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSVKKALQKALVPGR---------DCLTPVMAVSMLTLQEVPIVIMANPDLEG--SLDSKIGIPSTSSEDTRLAQA--LGLPYSEVIEASPDGTERLS----------------------GSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKG-SAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHR----EPFHKLLAQGLIKGQTFRLP-SGQCLKKEDIDFTGP-----APVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTSGTVPQPQLLNSKEKTKAQNLWEYKNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGLTLVPSKL---CDHYAWDSGVMLQAWPTVDSQF-----LQKPDMVQMAVLINNKACGKIPVP--QHVAQDQDKVHELVLQSEL---------GMKLLQGRSIKKAFLSPRTALINFLVQE---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15031-1", "uniprot_id": "SYLM_HUMAN", "id": "Q15031-1", "name": "Leucine--tRNA ligase, mitochondrial", "aln": "MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAD--LPEWYG-IKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGK---------DCLTPVMAVNMLTQQEVPVVILAKADLEG--SLDSKIGIPSTSSEDTILAQT--LGLAYSEVIETLPDGTERLS----------------------SSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKG-AAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHR----EPFHKLLAQGLIKGQTFRLP-SGQYLQREEVDLTGS-----VPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKL---CAHYTWDASVLLQAWPAVDPEF-----LQQPEVVQMAVLINNKACGKIPVP--QQVARDQDKVHEFVLQSEL---------GVRLLQGRSIKKSFLSPRTALINFLVQD---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VZ82-1", "uniprot_id": "Q9VZ82_DROME", "id": "Q9VZ82-1", "name": "leucine--tRNA ligase", "aln": "MQALRRTRPWGAVYWN----------SWRRLLTQSCTR-------NDNPELTSDVKHRIEAHWREQLSGGQFNPKDS---QDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRD-IINLQRHWIGECDGYAFNLLTSASG-----LLRVWTTHPEHLKDP------------HAFLVLRSNHHLSKLKGA---------DSLS---AANPFAGTTMPVVFSDEVTFPP--KSDVYLAAPSFRGEDKDLWDS--YGLAFTS------NGKDEES----------------------LSPANWEMLRKEVLQAATR----LNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSLP-----------PKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTS----EPFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKK--NQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWSSAT--FPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLSIKVNGFENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNIYVDKAKMKQKPPTTDDAEAQPQA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P11325-1", "uniprot_id": "SYLM_YEAST", "id": "P11325-1", "name": "Leucine--tRNA ligase, mitochondrial", "aln": "MLSRPSSRFLST---------------------------------KRGPGPAVKKLIAIGEKWKQKTTRG--LPKQDTLNSGSKYILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERSINPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDPVDMTVLANEQVDAQGRSWRSGAIVEKKQLKQWFLGITKFAPKLKKHLNQ--LKDWPSNVKQMQKNWIGESVGAELVFKVADPKFEN---LIVFTTRPETLFAVQYVALALDHPIVQKYCEEMPDLKEFIQKSDQLPNDTKEGFQLPNIKAVNPLTKEEVPIFAAPYVVSSYGSAPSAVMGCPGHDNRDFEFWQTNCPGEHIKTCIAPFFDDASKVTEQERQRIIDTVPFTSTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLDTKG-NPLSTIDEFVNVACPSCGS-PAKRETDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVEHAILHLLYSRFIAKFLGSINAWSDPAGIFEPFKKLVTQGMVQGKTYVDPDSGKFLKPDELTFVNDSPDGNTVIIKSNGKVPVVSYEKMSKSKYNGADPNECILRHGPDATRAHILFQSPIADALNWDESK--IVGIERWLQKVLHLTKNILSLEKDLAISKDYKTPTDLNDAEVKFHNDFQRFLKSITESFEVNLSLNTVISDYMKLTNILESALKKGEVRNEMIVQNLQKLVTVIYPAVPSISEEAAEMINSQMEWN--------------QYRWPEVERTT-------ESKFKKFQIVVN-GRVKFMYTADKNFLKLGRDAVIETLMNLPE---------GRMYLMNKKIKKFVMKFN--VISFLFHK---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : . : : . : *::: . .: . . *:*. ****** **:**:***.::*:: ** : * :*::*****:********* :*.:.* **..** :*::*:. : *.*::*::** *.***:** :*: *.. ****::** :****** ****:***: * ****** **:* *:***: : :* : . * : * :* . : :* :***:. * : : * .:*: ** : : : . *. *.. :: :*:. . :. *. ..* : :: * . :. .. : . : . : :. . *::***:************:** **..*** .:*** ** * * . ** * *:*********:**:***:*: *.:*. *. ::. ****:**** ***::** *:**: :* *** :*:.**:: *::: **: : :: :.. : .. : :::******* **.:*.: . .:* *: * ** . . *. . : *: .* ::: : . . . .. . .: : : : * : *. .:*. *:. * : : :. : * : : * .* .:.* : ** :: . : : :: : . : . : * . ::: * : . : * :. . . . ", "identical_positions": 219, "similar_positions": 232, "identity": "22.48%" }, { "cls_id": "homologset.agr.HGNC:17097", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZBP3-1", "uniprot_id": "D3ZBP3_RAT", "id": "D3ZBP3-1", "name": "Exosome complex component RRP4", "aln": "MALEMRLPRARKPLSES--------------------------LGRDSK--KHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGALVQVSPALVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEH---------------------------------KDEE-AGGFIANL-EPVSLSDREVISRLRNCIVLLVTQRMMLYDTSILYCYEASLAH-QIKDILKPEVMEEIM--LETRQRLLEQEG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VBV3-1", "uniprot_id": "EXOS2_MOUSE", "id": "Q8VBV3-1", "name": "Exosome complex component RRP4", "aln": "MALEMRLPKARKPLSES--------------------------LGRDSK--KHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEH---------------------------------KDED-AGGFIANL-EPVALSDREVISRLRNCVVLLVTQRMMLFDTSILYCYEASLAH-QIKDILKPEVMEEIM--LETRQRLLDQEG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13868-1", "uniprot_id": "EXOS2_HUMAN", "id": "Q13868-1", "name": "Exosome complex component RRP4", "aln": "MAMEMRLPVARKPLSER--------------------------LGRDTK--KHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEH---------------------------------KEEE-AGGFIANL-EPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPH-QIKDILKPEIMEEIV--METRQRLLEQEG", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F8W3K6-1", "uniprot_id": "F8W3K6_DANRE", "id": "F8W3K6-1", "name": "Exosome complex component RRP4", "aln": "MAVEMRLPAVHKHVSLK--------------------------TGQSSREDKHLVVPGDVITSDTGFMRGHGTYMDEDRLTASVAGQVERVNKLICVKPLKTRYNGEVGDVVVGRITEVQQKRWKVETNSRLDSVLLLSAVNLPGGELRRRSTQDELAMRDYLQEGDLISAEVQSIFSDGALSLHTRSLKYGKLGQGVLVYVSPSLVKRQKTHFHNLPCGASLILGNNGYVWLSPTPAL---------------------------------QEEQ-AGGFYTSM-EPVSLSDREVVSRLRNCLLALANQKVLLFDTSVLYCYEASLQH-QIKDILKPEIMEEIV--LETRQRLMEHEG", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W1M9-1", "uniprot_id": "Q9W1M9_DROME", "id": "Q9W1M9-1", "name": "Exosome complex component RRP4", "aln": "MSTNAAIDLALDRVDWRD-------------------------LAAQTEEQPRVYTPGEVLMPEAGFMRGHGTFVEDENIKSSVAGVIQKVNKLISVRPLKSRYVGEIGDVVVARVSEVQQKRWRVDTNSRLDSILLLSSVNLPGGELRRRSAEDEQMMRRYLDEGDLISAEVQNIFEEGSLSLYTRSLKYGKLSQGILVKVFPALVKRRKMHFHNLPCGASVILGNNGYIWISPTKGQ---------------------------------EEEGGEGGFAQNLNEHVPRADREVIARLRNSILALAKCKLMIYDTSIQYAYEESLRY-EAHELLQQNAIYDIG--QQTQARLRDADE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38792-1", "uniprot_id": "RRP4_YEAST", "id": "P38792-1", "name": "Exosome complex component RRP4", "aln": "MSEVITITKRNGAFQNSSNLSYNNTGISDDENDEEDIYMHDVNSASKSESDSQIVTPGELVTDDPIWMRGHGTYFLDNMTYSSVAGTVSRVNRLLSVIPLKGRYAPETGDHVVGRIAEVGNKRWKVDIGGKQHAVLMLGSVNLPGGILRRKSESDELQMRSFLKEGDLLNAEVQSLFQDGSASLHTRSLKYGKLRNGMFCQVPSSLIVRAKNHTHNLPGNITVVLGVNGYIWLRKTSQMDLARDTPSANNSSSIKSTGPTGAVSLNPSITRLEEESSWQIYSDENDPSISNNIRQAICRYANVIKALAFCEIGITQQRIVSAYEASMVYSNVGELIEKNVMESIGSDILTAEKMRGNGN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: : .. . .:. :: .**: : :. :******:. :: :**** :.:**:*:.* .** ** * ** **.*::** :***:*: ..: .::*:*.::***** ***:* .** ** :*.****:.**** :*.:*: **:********* :* : * .:*: * * * *:** . :::** **::*: * ::* : . :. *:.:.* * : *. .: : : : .** *: : : :::: : : .* * :: ", "identical_positions": 95, "similar_positions": 98, "identity": "26.46%" }, { "cls_id": "homologset.agr.HGNC:17098", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M5C7-1", "uniprot_id": "A0ABK0M5C7_RAT", "id": "A0ABK0M5C7-1", "name": "Endoribonuclease Dicer", "aln": "MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLSPHAKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWSQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMK--LCDSCPS-CPRILGLTASILNGKCDPDELEEKIQKLEKILKSGAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALDFINDCNVSVHSKE------------RDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTLLRKIHALCEEYFS--------PASLDLKYVTPKVMKLLEILRKYKPYE--------------------------------------------RQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPE--TNFPSPFTN-----------------ILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLAD-------------------------------------------------------------------------------------------------------------------------------------------------TDKIKSFEEDLKTYKAIEKILRNKCSKSVDGAEADVHAVVDDDDVFPPYVLRPDDG-GPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDG---TFYSTLYLPINSPLRASIVGPPMGCVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEE------ELDLHDEEETSVPG--RPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELVTRLHQYIFSHILRLEKPALEFQPAGAESAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLP-ADFRYPNLDFGWKKSIDSK-SFISTCNSSLAESDNYCKHSTTVVPENAAHQGATRP-SLENHDQMSVNCKRLPAE----------SPAKLQSEVSVDLTAINGLSYNKSLANGSYDLVNR-DFCQGNQ-------------LTYFKQEIPVQPTTSYPIQNLYNYENQPTPSNECPLLSNKYLDGN--------ANTSTSDGSPAGSPRPAMMTAVEALEGRTDSEQSPSVGHSSR---TLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPD------AHEGRLSYMRS-------KKVSNCNLYR----------LGKKQGLPSRMVVS-IFDPPVNWLP--------------------PGYVVNQD----KSNSEKWEKDEMTKDCLLANGKLGEDCEEEEEE--ELAWRAPKEEAEYEDDLLEYDQEHIQFIDSMLMGSGAFVKKIPLSPFSTSDSAYEWKMP----------------KKASLGSVPFSSDLEDFDYSSWDAMCYLDP---SKAVEEDDFVVGFWNPS--------------------------EENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTSRDKASYPAQENSSSQQKSPSGSCAAA--VSPRSSAGKDLEYGCLKIP-PRCMFDHPDAEKTLNHLISGFENFEKKINYIFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPLVPNS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R418-1", "uniprot_id": "DICER_MOUSE", "id": "Q8R418-1", "name": "Endoribonuclease Dicer", "aln": "MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSDLEVNASWTKERWSQEFTKHQVLIMTCYVALTVLKNGYLSLSDINLLVFDECHLAILDHPYREIMK--LCESCPS-CPRILGLTASILNGKCDPEELEEKIQKLERILRSDAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEAALDFINDCNVAVHSKE------------RDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTLLRKIHALCEEYFS--------PASLDLKYVTPKVMKLLEILRKYKPYE--------------------------------------------RQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEKEKPE--TNFPSPFTN-----------------ILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLAD-------------------------------------------------------------------------------------------------------------------------------------------------TDKIKSFEEDLKTYKAIEKILRNKCSKSADGAEADVHAGVDDEDAFPPYVLRPDDG-GPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDG---TFYSTLYLPINSPLRASIVGPPMDSVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEE------ELDLHDEEETSVPG--RPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPALEFKPTGAESAYCVLPLNVVNDSGTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLP-VDFRYPNLDFGWKKSIDSK-SFISTCNSSLAESDNYCKHSTTVVPEHAAHQGATRP-SLENHDQMSVNCKRLPAE----------SPAKLQSEVSTDLTAINGLSYNKNLANGSYDLVNR-DFCQGNQ-------------LNYFKQEIPVQPTTSYPIQNLYNYENQPKPSNECPLLSNTYLDGN--------ANTSTSDGSPAVSTMPAMMNAVKALKDRMDSEQSPSVGYSSR---TLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPD------AHEGRLSYMRS-------KKVSNCNLYR----------LGKKKGLPSRMVVS-IFDPPVNWLP--------------------PGYVVNQD----KSNSEKWEKDEMTKDCLLANGKLGEACEEEE----DLTWRAPKEEAEDEDDFLEYDQEHIQFIDSMLMGSGAFVRKISLSPFSASDSAYEWKMP----------------KKASLGSMPFASGLEDFDYSSWDAMCYLDP---SKAVEEDDFVVGFWNPS--------------------------EENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTSREKALDPAQENGSSQQKSLSGSCAAP--VGPRSSAGKDLEYGCLKIP-PRCMFDHPDAEKTLNHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVKFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPY3-1", "uniprot_id": "DICER_HUMAN", "id": "Q9UPY3-1", "name": "Endoribonuclease Dicer", "aln": "MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMK--LCENCPS-CPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKE------------RDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFS--------PASLDLKFVTPKVIKLLEILRKYKPYE--------------------------------------------RQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPE--TNFPSPFTN-----------------ILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLAD-------------------------------------------------------------------------------------------------------------------------------------------------TDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPPYVLRPDDG-GPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDG---TFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEE------ELDLHDEEETSVPG--RPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLP-ADFRYPNLDFGWKKSIDSK-SFISISNSSSAENDNYCKHS-TIVPENAAHQGANRTSSLENHDQMSVNCRTLLSE----------SPGKLHVEVSADLTAINGLSYNQNLANGSYDLANR-DFCQGNQ-------------LNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGN--------ANKSTSDGSPVMAVMPGTTDTIQVLKGRMDSEQSPSIGYSSR---TLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPD------AHEGRLSYMRS-------KKVSNCNLYR----------LGKKKGLPSRMVVS-IFDPPVNWLP--------------------PGYVVNQD----KSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMP----------------KKSSLGSMPFSSDFEDFDYSSWDAMCYLDP---SKAVEEDDFVVGFWNPS--------------------------EENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSEYGCLKIP-PRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6TV19-1", "uniprot_id": "DICER_DANRE", "id": "Q6TV19-1", "name": "Endoribonuclease Dicer", "aln": "----------MAGLQLVTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALEHNTIVCLNTGSGKTFIAVLLIKELSHQIRGE---NGKRTVFLVNAASSVAQQASTVRTHSDLQVGDYMSEDMTS-WPEEMWNREMIENQVLVMTCHIFLHVLKNGVLPLSKINLLVFDECHLAITGHPYREIMK--ICEGCPS-CPRILGLTASILNGKCDPCDLEEKIQNLEKILQSNAETATDLVVLDRYASQPREEVLDCGQYQDQSGLSERLLNELDEALNFLNDCNLSVHRED------------RDPTFISKQVLNDCRAVLTVLGPWCADKAAGIMVRELQKYIKHEQEELNRKFLLFTDTILRKIHALCEEHFS--------PASLDLKFVTPKVIRLLEILHEYKPFE--------------------------------------------RQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEAEAKEKTE--ANFPSPFTN-----------------ILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHSIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPVSNYIMLAD-------------------------------------------------------------------------------------------------------------------------------------------------SERTKTFQEDLKTYKAIEKILRNKCSKSAECNDFELEPVTDDDNVLPPYVLRSEDG-GPRVTMNTAIGHVNRYCARLPSDPFTHLAPKCKTVEMNTG---GYRSTLFLPINSPLRVPVTGPVMNCARLAEKAVALLCCEKLHKIGELDDHLMPVGKETVKYEE------ELDLHDEEETSVPG--RPGSTKRRQCSPKAIPECLRGCYPVPEQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPRIPHFPVYTRSGEVTISIELQKSGFSLSAEQLELITRLHQYIFSHILRLEKPALEFKPVEADSAYCVLPLNIVEDSNTLDLDFKFMEDIEKSEARIGIPNTQYTKQNPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLSNVNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRSQTAIDAGVGAQTLP-PDFRYPNLDFGWKKSIDSK-SFISCPSACMEEDDDHCKLGTSSDSNHTAPESCSMEVSQPPEGAPNTPDEKLETL----------TLP------VTDLNKDCFPNLPNGTQADSDDLPHRSDVCQCSQ-------------LGPLERDLSTQTTTSVSVRPSPAGEPQPWPSDECTGRSSDLCDPH--------VKKPTSKHCPKSETATSTPAPSETSSEDCRSACAGPAWDSPK---TLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPD------AHEGRLSYMRS-------KKVSNCNLYR----------LGKKKGLPSRMVVS-IFDPPVNWLP--------------------PGYVVNQD----KSSTDKWDSDENKD---LANGKASDDEDEDDDDEPEEAEVEPSKEDVNVEDDLEYYYEHIRFIDSMLIGSGAFGKKISLQP---TDPGYEWKAP----------------KKAHNSHFSPDGGADEFDYSSWDAMCYLDP---SKAGEEDDFVVGFWNPS--------------------------EENCGTDIGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPPEKQS---------------------------------SGGSAELQYGWLKIP-PRCMFEHPDAERTLNHLISGFLNFESKINYTFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVQNN", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VCU9-1", "uniprot_id": "DCR1_DROME", "id": "Q9VCU9-1", "name": "Endoribonuclease Dcr-1", "aln": "---------------------------MAFHWCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVSVYLSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHC---WTDYHVSILRPEGFLYLLETRELLLSSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPF-EMDELSLVLADVLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHFYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCAN-TEPPEQEQSEAERFSACLAAYRPKPHLLTGASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDSTENCVFIVPT-VKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQ-AQPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPD-LVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDN--WLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLD-----------GGNQEQRIPGSTKPN-------AENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLS-EEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRIAKCTAAKCALRQLKKQGLIAKKD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.: * :: :* .::***.:***** :* ::***:**. *.* ***: * :**: : * :.: :*:* .. :: * :.* . : . : . :* :: * :*:. * **.::*:*:::** : : * ::: : *: ******:..: .. *: :*. : .**: : . ***:*:*.: ** *:* * :::*. : : . * * *: .*: * . : *... . :::.. .** :****:::.* : : :* : .* : : :..* * ::::***. * . . :: :*** :**: *: :** * * . ::* : .:*. .. * :. . * *.. :* ..* *. **.:*: ::.:** ** .*: * .::**:* :: .:: *.: :.. .. *: * *.*:*****::** *: *:**.**::***:*:********:* ** ******.******. : :::*. :. * : .:: *: **::* .**:: .: : : . :..* :.. *. * :.:**. :*:********.**:*:. : . . : ** *******: :.* * **.: .** .* :**:*****::* *:*** .: * **: .**: ..:.. ***:***** * *.. : . * . *****.* :.* *:*:* * * **:*****: : *****:* **::. *.::******.:*:** *. . *: : : :. : :* *:::***:* : *.* ::.. ::* : :. .:*::*:* *: . : . .. :: . *. : :****::* *** ***: ****:: ..*:*** **. :*.** .** .**.* : * .**********:***:****::*:** *** ** *.::** *.*::*********::**:******.*****.****:: ** *:::* *.: * *:* : : **.:* *****. * * * * . . :. * : :: : * . .. : *: . :. * . ..*: . : . * . . : : :. .. * . :. :*. . . . : : : .. . * .* ***::: : : ::: : : * : .*: :* ** *** :* : *.** * .:::* :.: .:*:. : :* * * . :: : : .. ::.. . : *. . :. : *.: :*.. : *. : :* * . :: . : .* * . ** * .** * .: . .*: : *:* *.: *: . *.*:* :::.*.***********:*.** .** *.* **:. **::*** :: . ** * . :. *:* . *::*:*** **..:.* *::::*****:***** * :*************:******:************.*******************::.:**:*: :** * .*** **::* *:.. . : * **: :. **:*****:**:***:****::**.***:.**:** ** * **:** .**:**:*****:*******. .*: ** :*****:*. **.*:*:**.*****.:**: ***.** : . :.", "identical_positions": 631, "similar_positions": 572, "identity": "27.32%" }, { "cls_id": "homologset.agr.HGNC:171", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q04771-1", "uniprot_id": "ACVR1_HUMAN", "id": "Q04771-1", "name": "Activin receptor type-1", "aln": "MVDGVMILPVLIMIALP--------------------------------------------SPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCE-----GQQCFSSLSINDGFHVYQ-KGCFQVYEQGKMTCKTP------PSPGQA-----VECCQGDWCNRNITAQ--LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQ---ERLNPRDVEYG------TIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P37172-1", "uniprot_id": "ACVR1_MOUSE", "id": "P37172-1", "name": "Activin receptor type-1", "aln": "MVDGVMILPVLMMMAFP--------------------------------------------SPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCE-----GQQCFSSLSINDGFHVYQ-KGCFQVYEQGKMTCKTP------PSPGQA-----VECCQGDWCNRNITAQ--LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQ---ERLNPRDVEYG------TIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P80201-1", "uniprot_id": "ACVR1_RAT", "id": "P80201-1", "name": "Activin receptor type-1", "aln": "MVDGAMILSVLMMMALP--------------------------------------------SPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCE-----GQQCFSSLSVNDGFRVYQ-KGCFQVYEQGKMTCKTP------PSPGQA-----VECCQGDWCNRNVTAR--LPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQ---ERLNPRDVEYG------TIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M9QFK8-1", "uniprot_id": "A0A8M9QFK8_DANRE", "id": "A0A8M9QFK8-1", "name": "receptor protein serine/threonine kinase", "aln": "MGHCSTQIIILFLLQFL--------------------------------------------QTSAKDVS-------IDCMCVGSDC-NEQQCT-----GDQCYTSVIISNDVTTFK-RGCLIGPASKRMTCSAT------ASASHV-----VECCSQHMCNANVSKETLLRLLLTSPEEGKTVHYRVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGRLERLHEFDTEQG------AIDGLIASNVGDSTLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCFDAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKIHSSLEKGKTDC-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K7J3-1", "uniprot_id": "A0A0B4K7J3_DROME", "id": "A0A0B4K7J3-1", "name": "receptor protein serine/threonine kinase", "aln": "MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPEL-LPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHR---KRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDEVCV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : :* :: . . . * . * : . . **:.* . . . : :** . * *. .* :. * ** . ** . . * .. : ::: *: .. ::. : ::: :* :: :** .: . : * ::..***** : ::** *********:*****:*:*::*:**:*:*:******* *:**.:***** ****:** ****:*.*::*********:.******:*.*****:***: ***:*:*: ::. . : : ***.**.*** ****.:**.*:************..: .* ***:**** *:: .***:****:**************:*: :**:: :*.**:********:.** :* **.*:** ****:** ****:*******::: ** ***** **. ::.: *******:***..**.*******: *: .: :* : * ", "identical_positions": 234, "similar_positions": 138, "identity": "39.93%" }, { "cls_id": "homologset.agr.HGNC:17101", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AIG5-1", "uniprot_id": "A0A8I6AIG5_RAT", "id": "A0A8I6AIG5-1", "name": "", "aln": "MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAVASGGKSGGGGCGGGGGYSASSS----SAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQES-------HSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRN---REDGE--KTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPIS---KKRATWETILDGKR--LPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQEN-KPGSVKPAQTIAVKETLTTEMQTRKEKDTSNETRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSR-NGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLR-------------------------------------------------------------------------EMQQKLEKGESAAPANEDIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL----------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80U70-1", "uniprot_id": "SUZ12_MOUSE", "id": "Q80U70-1", "name": "Polycomb protein Suz12", "aln": "MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAAS-GGKSGGGGCGGGGSYSASSSSAAAAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTSIKRKTFKVDDMLSKVEKMKGEQES-------HSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRN---REDGE--KTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPIS---KKRATWETILDGKR--LPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQEN-KPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSR-NGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLR-------------------------------------------------------------------------EMQQKLEKGESATPSNEEIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL----------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q15022-1", "uniprot_id": "SUZ12_HUMAN", "id": "Q15022-1", "name": "Polycomb protein SUZ12", "aln": "MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATAS-GGKSGGGSCGGGGSYSASSSSS--AAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQES-------HSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRN---REDGE--KTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPIS---KKRATWETILDGKR--LPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQEN-KPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSR-NGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLR-------------------------------------------------------------------------EMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL----------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0R1D5-1", "uniprot_id": "SZ12B_DANRE", "id": "B0R1D5-1", "name": "Polycomb protein suz12-B", "aln": "MAPQKY---------------------SAQVMNSKAN-------------------------GAVYPSSGVSSLKKPKIEQLQADHELFLQAFEKPTQIYRFLRTRNLITPVLLHRTLTFMSHRNSRTNAKRKSFKVDDLLSSVEKMKGEPES-------PSLTSHLQLTFTGFFHKNVKPCQNSENEQNSVSLEVLLVKVCHKKRKDVSCPIKQVPTGKKQVPLNPDLSQTKPGAFPSLLVSSNEFEPSNSHMVKSYSLLFRVSHTGKRDPNGFISCEADENIDVKDEIPPRRKRNSSLRGDGETTETFVAQMTVFDKNRRLQLLDGEYEVSMQQIEDCPVS---KKRATWETILDGKR--LPPFETFSQGPTLQFTLRWTADPSDPSTAPVAKPLSTRNSDTSTTES-RISTLRPAP-VAVKESVSTSMQSRIEHS-PCEPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLSHSRFIFNYVPHPKGARIDVSINECYDGSYVGNPQDIHSQPGFAFSR-NGPVKRTAVTHILVCRPKRTKPSLSEFLESEDGEPEQQRTYVSGHNRLYFHSDSCMPLRPQEMEVDSEDERDPEWLQEKTTTQIEEFTDVNEGEKEVMKLWNLHVMKNGFIADNQMSQASMLFVEICGPHIIRRNLCRNFLLHLVNLHDFNLVTIATIDQAMARLK-------------------------------------------------------------------------EIEESFPELEAGQ-------ESLDATCNGHSLS---------LGFSLHGKCTKLES-----------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q6DC03-1", "uniprot_id": "SZ12A_DANRE", "id": "Q6DC03-1", "name": "Polycomb protein suz12-A", "aln": "MAPQKHG------------SGGNGFYGNSASKAANGG-------------------------AHASSGVVMTSVKRLKMEQIQADHQLFLEAFEKPTQIYRFLRTRNLITPIFLHRSLTYMSHRNSRTNSKRKSFSLNDLLFKVEKSKVDPES-------HNLASNLQLTFTGFFHKTEKQLQNSENEENSVSVEVLLVKLCHKKRKDVTCPVKQVPTGKKQVPLNPDISPTKLGAFPTLVVPSHEFEPVNSNTVKSYSLLFRASRPWGREHNGMTTRDT----NVIEELSNRKKRYCSHQDDGE--TTFVAQMTVFDKNRRLQLLDGEYEVSMQEIEESPVG---KKRATWETILDEKW--VPPFETFSQGPTLQFTLRWTNDTADKATAPVAKPLATRNSESSTVDSSKTSNIKPPQAVAVNDSLGTDLPVRREQT-HIEPCQKLHVYYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLSHSRFIFNYVPHPKGARIDVSINECYDGSYVGNPQDILCQPGFAFSR-NGPVKRTPVTQILVCRPKRSKPSLSEFLEPEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEMEVDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMKHGFIADNQMNQACMSFVEQHGTIMVEKNLCRNALLHLINMHDFGLITTATIDKAMTHLR-------------------------------------------------------------------------DLTQQSIAQH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9NJG9-1", "uniprot_id": "SUZ12_DROME", "id": "Q9NJG9-1", "name": "Polycomb protein Su(z)12", "aln": "MAPAKKREKDSN----PDGSAANGIIGLTHGAPDASN---------------------------AGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESITQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNP---KDRVGEHATISIPLQTMRPMG-EQHTLYKLLFRIKVLSPSTCN-----------DENAETPPNKRSR-----PNE--KMFGSELILYEKSS-GFITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPDSYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSGGGNSTVCKT----TPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDNTVLNKRQRYSDGSPGTGIGNGHGGGSGSGANRNKSNNHSLPATSNNASSSSSNSKRAIARRRSTSERTKASGSTGGGAGGVRTRLSVPAKYERR", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32832-1", "uniprot_id": "RSC7_YEAST", "id": "P32832-1", "name": "Chromatin structure-remodeling complex subunit RSC7", "aln": "------------------------------------------------------------------------------------------------------------MSDSEGGLASEVEHEKRSRSTSNRPNYAIDTEDLDIDENDENEDD----------------------DYREEEANEGVNEEEISDEEEQINKSGRNKRRHVDE--EEDLSEDKGVTRSRNRSKFKKPVFPGIDDAEENLNPLK-VVNEEYVLPDDPEGETKITADG--------------DLLGGR-------------EFLVRTFTLTEKGNRKFMLATEPARIVGFRDS---------------------------YLFFQTHPNLYKFILNQTQKNDLIDRGVLPYSYRNRQIALVTARGVFKEFGAKIIRGGKHITDDYYASELRT-------KGNVIEGKLAGDPIDKSARALETMMYPASENGINPAKNQVEFFEHRPHGHMSNSNIIASGSKLSSTN-----WLYQHSAACSRFNSDLFYDR----------VKVLLVDQQGLRDAYTNILHIPES---TQSTTVLGWRRSKNDSPSDTSIVYETVIHDNDLNKPKTGLSEIPKEIYEDVVDEDVLR---------------AITEQQNFEKCNEYI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: **.. :* .: :: .: : . .. : : * : * :.**:. .: : . : . : .. : . . :.* * * : : : : : : :*. : * : :. : * : : . :: : . . : : .: : .: :.:. : : * . . ::.:: . . .*:::. : * .. .. : * . ::: : : . ::*. :. * : * .* .: : .: : : *.: : * : . ::. * : . : : * . :: ", "identical_positions": 25, "similar_positions": 127, "identity": "2.61%" }, { "cls_id": "homologset.agr.HGNC:17102", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M2BHU6-1", "uniprot_id": "A0A8M2BHU6_DANRE", "id": "A0A8M2BHU6-1", "name": "", "aln": "--------------MLKRVSSNKSYSPYATSQ--------RVKKSSSKKKL------------------DILPNKPNVWL-----KQLSALQEQPRKDAVDSVTSSSQTSSSLSPPIVEVSSSCPGTPLTQHSKALGCPSPMGTLKRPTSLSRNPSAAGFPIQS---WVFSKGAGKSVIAQSPSPETADTTVAIEVEDIPSLLRSVERFAKAVEKLKDVVLEDKQEN--RRPLAHECLGEVLRVLRQVISMYPLLNTVETLTAAGKLISQVKGYHYESCIEPEKKDFEKAIETIAVAFSSNVSELLMGEVDSSTLLSVVPTEKSRSMENLS----GHGSSHTWGDSSELAMSAEEVDIILQRSEGGVDSALTYAKTISKYLKDLIGYVERKLALELEFSKGLQRIYQSCKQTITQP-HMPFFTIYSQALEQDLEQSNGMHQAAATLQNQTFIMPLMVRKQEHEKKRKEIKEQWLKAKRKLMECDVNLRRAKQVYMTRCEEYDKARTAANRAEEE-------GGSATTKTLDKKKRLEEEARNKAEEAEATYRTCIADAITQH-QELEHMKVTVLRGIQEVIKQTDQTIRSATISYYQIMHMQTVALPVHYQTLCESSKQYDPGQQYGTHVKDLQMSEEPETHYEFEAYSAS-SVQQSVRPRTDS-ANAEAQSSAEVPQTAGETG---DTSSSQKDDQKRARGHMTHKSWGSTVSDTDSVGGGSGLESPTTSTGDISKMTRTSSTGTMSSNEDIDEKDA--NVTSFETPNINGIEPEI--VVPTGPFRNIGLSKAAQTHKLRKLRSPSKCRECDSYVYFQGAECEECFLACHKRCLETIAIQCGHKKLQGRLQLFGQDFLQVSSNSPDGIPFIIKKCIAEIERRALRMKGIYRVNGVKTRVEKLCQAFENGKELVELSQSSPHDISNVLKLYLRQLPEPIMPFRLYNSLMGLAKESLAVVGPEGADSGKGPDLMDLGPETDPELLVLVDRLKNLLKELPKPNTATLRYLARHLRRIAELEDDNKMSPSNLGIVFGPSLMRPRPSGATVSLSSLVDYPYQARIVETLIVFYPSIFQSESSRPASSSTRTQ-------------SLQQQSSIDEERCSNDEQGLPDEPAAVELDKLEDHAESCTGTPDSLEHSLDLDSDPEAEQPVDETSIQSRPAVLLVTLQS--------SSADPPALPESEPPELEDQSHSLAALNINQSNNTTKTLTS--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1QL19-1", "uniprot_id": "A0A8M1QL19_DANRE", "id": "A0A8M1QL19-1", "name": "", "aln": "-----------------------MFSRKKKEQ--------ATKTPTASKKS------------------NSAQNPS-----------LSILQEHSQNDTMD--------GSSMLTPPDSVALSCPGTP-CAHSRLSGCSSPVGTVRRPPGLSRHASAAGFPFQTSGTWGFHKGYVRAPLNYGQAAEGLETSV-IEVEDIPSLLRDVARFAEAVEKLKDMVLGEVKEEPRSRPAVHECLGEVLRVLRQVISTYPLLNTVETLTAAGTLISKVKGFSYEGTTDAQKKDFEKAIETIAVAFSSNVSELLMGEIDSTTLLSLPPTEKSRSMEDLYRLSSGQGPEGGGKYDQQDCISPQEVDILLQRSEGGVDSALSYSKSIAKYMKDIISYVDKRIALENEFSKGLQRLYQSCKQNIIQD-HMPLLSIFSLALEQDSEQSCGLQQTTNNIYTHSFLQPMTQRRQEHEKKRRDIKEQWQRAKRKLADAESNLRKARQLYMSRCEEYERARTVANKVEEEQSGT---GSGSTTKALDRKRRLEEEARNKAEEAEATYRTCIADATTQQ-QELEDMKVNVLKQIQELIRQTDQILRACTISYYQTMHVQTAALPVHFQTLCESCKLFDPGQQYAAYVKNLQLRTERPLQYQFEPYSAS-SHQQLLRTRNNSLSNDQRQNSCEAPTTPEEAGFGEGTVVKQRRGQVRDH-HQAHKSWPSTLSDTDSVGPGSGLGSPTNSTGDISKPSRPVSAATLSSNEDLEERDG--AMTQFEQS-INGIEPEI--VAPTGPFRNVGLSKAAKTHRLRKLRTPSKCRECDSYVYFQGAECEECFLACHKKCLESLAIQCGHKKLQGRLQLFGRDFSQVLHGKEDAVPFIIKKCITEIERRALKMKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPIMPFRMYNELMGLAKESLNSDASESTDGVKSPELVDRGPETEAEVLTLVDKLREVLKRLPNANIATLKYIIQHLRRVSELEQENKMSASNLGIVFGPTLMRPKPTGATVSLSSLVDYPHQARIVEALIVFQQSIFICTTKSPAQRQDSET-------------GAHEEPIRAHQECGETAHGDSVGSSGSQERSLDSDSDVEDPAAGFRPHRPPLVSQ-ESETSTEEDQLSPR-----ASLDL--------SGLVPETIPEQSVPEPAENTSGRSQQ----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0ABK0L8V3-1", "uniprot_id": "A0ABK0L8V3_RAT", "id": "A0ABK0L8V3-1", "name": "", "aln": "MRSGFWNVPDCVEDPGTFLVQPEAHPRASQSSNRHNLSNPLPSQPTMSGRRGPLKELLGWVCGWTRAWRTRLGTTGCGLSGLCPGEPPSVSEELPRKD--------CTETPSLEPPAMSLSTVAKGTG---------------TLKRPTSLSRHASAAGFPLSGTATRTLGRGYRSPLSAASPAELPTEGPFPDGVEDISTLLADVARFAEGLEKLKEFVLRDDLLEA-RRPLAHECLGEALRVMRQVISKYPLLNTVETLTAAGTLIAKVKAFHYECNNESDKREFEKALETIAVSFSCTVSEFLLGEVDSSTLLAVPPGDPSQLVENLYG-SGSEGPPHSVEDCEEGCLPPEEVDMLLQRCEGGVDAALQYAKDMARYMKDLIGYLEKRTTLEMEFAKGLQKVVHNCRQNVTHAPHMPLLSIYSLALEQDLEFGHGMVQAVGTLQTQTFMQPLTLRRLEHERRRKEIKESWHRAQRKLQEAEANLRKAKQGYKQRCEDHDKARLQVAKAEEEQQGTGPGAGTAASKALDKRRRLEEEAKNKAEEAMATYRTCVADAKTQK-QELEDTKVTALRQIQEVIRQSDQTIKSATISYYQLMHMQTAPLPVNFQMLCESSKLYDPGQQYASHVRQLQRGEEPDVRYDFEPYVSTNAWSPIMRTRKGSFNPGDASGPEAAGSPPEEGG---TSEGAPNKDHRGGRGHQVHKSWPISISDTE-----VSLDVS---SGDLKKFDRTSSSGTMSSNEELVDQEAGLVASAFDSADLNGMDPELPVAMPSGPFRHVGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSQAAHSTPDGVPFIIKKCVCEIERRALHTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRFYHELVGLAKDSLKAEAEAKAASRGR----QDGSESEAATLAMVGRLRELMRDLPAENRATLLYLLRHLRRIVEMEQDNKMTPGNLGIVFGPTLLRPRPTDATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEEAAGSQEGAS-------AQCAQLETAEGIVFPQQEEADDGNRESQVASNDSDSELEEASDLLSSSDASALHRLSFLEQ--TEAGLEEGPQSHSGSE--EQLES--------EDAAPGHQLCSFNTNQSNNTTQASLPTMRLRDGQITGGSGRKRQPQFV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3TBD2-1", "uniprot_id": "HMHA1_MOUSE", "id": "Q3TBD2-1", "name": "Rho GTPase-activating protein 45", "aln": "-----------------------MFSRKKRE---------LMKTPSISKK-------------------NRAGSP----------NPQSSSGELPRKD--------WTEAPGLEPPATSLSTVAKGTG---------------TLKRPTSLSRHASAAGFPLSGTATWTLVRGYRSPLSAASPAELPTEGAFPDGVEDISTLLADVARFAEGLEKLKECVLQDDLLEA-RRPLAHECLGEALRVMRQVISRYPLLNTVETLTAAGTLIAKVKAFHYECNNESDKREFEKALETIAVSFSCTVSEFLLGEVDSSTLLAVPPGDPSQSMENLYG-AGTEGPPHNVEECEEGCLPPEEVDMLLQRCEGGVDAALQYAKDMARYMKDLISYLEKRTTLEMEFAKGLQKVVHNCRQSVTHEPHMPLLSIYSLALEQDLEFGHGMVQAAGTLQTQTFMQPLTLRRLEHERRRKEIKESWHRAQRKLQEAEANLRKAKQGYKQRCEDHDKARLQVAKAEEEQQGTGPGAGTAASKALDKRRRLEEEAKNKAEEAMATYRTCVADAKTQK-QELEDTKVTALRQIQEVIRQSDQTIKSATISYYQLMHMQTAPLPVNFQMLCESSKLYDPGQQYASHVRQLQRGEEPDVRYDFEPYVSNNSWSPIMRTRKGSFNPGDASGPEAAGSPPEEGG---TSEAAPNKDHRGGRGHQVHKSWPISISDTE-----VGLDTS---SGDLKKFDRTSSSGTMSSSEELGDQEAGLVASAFDSADLNGMDPELPVAMPSGPFRHVGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSQAALSTPDGVPFIVKKCVCEIERRALHTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRFYHELVGLAKDSLKAEAEAKAASRGR----QGGSESEAATLAMVGRLRELMQDLPAENRATLLYLLKHLRRIVEMEQDNKMTPGNLGIVFGPTLLRPRPTDATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEEAPGSQEGAS-------TQCGQLESAEGIVFPLQEEAEDGSRESHAASNDSDSELEDASDPLSSSDASALHRLSFLEQ--TEAGLEEGPQSHSGSE--EQLEG--------EDGAPGPWLCHFNTNQSNNTSRAPLPTMRLRGGQITGGTSQERQPQFV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q92619-1", "uniprot_id": "HMHA1_HUMAN", "id": "Q92619-1", "name": "Rho GTPase-activating protein 45", "aln": "-----------------------MFSRKKRE---------LMKTPSISKK-------------------NRAGSP-----------SPQPSGELPRKDGADA----VFPGPSLEPPAG--SSGVKATG---------------TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLLADVARFAEGLEKLKECVLRDDLLEA-RRPRAHECLGEALRVMHQIISKYPLLNTVETLTAAGTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSSQSMESLYG-PGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQK-QELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGG---CTEGTPAKDHRAGRGHQVHKSWPLSISDSD-----SGLDPGP-GAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGR----QDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSE--EQLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P38339-1", "uniprot_id": "RGD1_YEAST", "id": "P38339-1", "name": "RHO GTPase-activating protein RGD1", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEETAKKPASATVSAKSSHDGGTDDLAHLFSTP-----------------------------------EIKKVLN-SDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFN-IQGSTNSSLKKMIHEVLG--FDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDP-----------TKTKLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENLVLNTGVTISPLDSTKSMKSFAG---------SVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPPK----FAVDPSRNSIPKRMISTHNESPFLSSSSN--------------TAAVPNANLNSATPSLNTNKQLP---------PTMASSISSTSNAAGAMSPSS-----SIVTSDTTSSITKTLDPGNNSPQIPEELIN-------SLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKN-------------------FMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDAN-------DVNFQIMAMEVLLEVSDQAFEPE-----------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*:: :. * : . *. * * : *:: *:. :*: .: .::: * * :::: :: :: ::* *. : *.: : : : : .: .: .* : . : :.: : : *:.:** : ::.: :. . .:*:. * *:: :: * : : . :. *** .* ::* *: : .: : : : . : :: ::::* : * : .* . . * . * .: . . . . * :: : . :. . . . . : .*:. *.:: :. . : :: ::.:.::: . :.. *:. .: .: * : * *.: . :: * ..: . : : :* .:: ** : * :* *:::*: *:: .* :**** .. *.** : :::. :.: .* . .. : * * : .: .*:.: . :: :: ** : :* : **:*: * :*:*. * *::**:: ..* *. * .* :*.*: * ", "identical_positions": 80, "similar_positions": 220, "identity": "6.47%" }, { "cls_id": "homologset.agr.HGNC:17103", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AAM0-1", "uniprot_id": "D4AAM0_RAT", "id": "D4AAM0-1", "name": "Transportin-3", "aln": "MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQD----VESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD------EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN-----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLN-YCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLK---EGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKP-------LASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQE---PSNGISSDPTVFLDRLAVIFRHTNP--IVENGQTHPCQKVIQEIWPVLSETLNKH--RADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEE--GCRQGLLDMLQALCIPTFQLLEQ------QNGLQNHPDTVDDLFRLATRFIQRSPVTLLRS-QVVIPILQWAIAST-TLDHRDANSSVMRFLRDLIHTGVAND-------HEEDFEVRKELIGQVMDQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDR-PTFCRWLENSLKGLPKETTVGAVTVTHK-QLTDFHKQVTSAEECKQVCWALRDFTRLFR---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P2B1-1", "uniprot_id": "TNPO3_MOUSE", "id": "Q6P2B1-1", "name": "Transportin-3", "aln": "MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQD----VESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD------EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN-----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLN-YCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLK---EGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKP-------LASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQE---PSNGISSDPTVFLDRLAVIFRHTNP--IVENGQTHPCQKVIQEIWPVLSETLNKH--RADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEE--GCRQGLLDMLQALCIPTFQLLEQ------QNGLQNHPDTVDDLFRLATRFIQRSPVTLLRS-QVVIPILQWAIAST-TLDHRDANSSVMRFLRDLIHTGVAND-------HEEDFELRKELIGQVMSQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDR-PTFCRWLENSLKGLPKETTVGAVTVTHK-QLTDFHKQVTSAEECKQVCWALRDFTRLFR---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y5L0-2", "uniprot_id": "TNPO3_HUMAN", "id": "Q9Y5L0-2", "name": "Transportin-3", "aln": "MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQD----VESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD------EKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN-----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLN-YCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLK---EGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKP-------LASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQE---PSNGISSDPTVFLDRLAVIFRHTNP--IVENGQTHPCQKVIQEIWPVLSETLNKH--RADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEE--GCRQGLLDMLQALCIPTFQLLEQ------QNGLQNHPDTVDDLFRLATRFIQRSPVTLLRS-QVVIPILQWAIAST-TLDHRDANCSVMRFLRDLIHTGVAND-------HEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDR-PTFCRWLENSLKGLPKETTVGAVTVTHK-QLTDFHKQVTSAEECKQVCWALRDFTRLFR---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VQG0-1", "uniprot_id": "Q9VQG0_DROME", "id": "Q9VQG0-1", "name": "Transportin-3", "aln": "MD--TYSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRD----LHANYFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQ-----QRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTIN-YCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQ---APETTWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKNG------LAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNP--DVPDNVEHPTVAILNDAWQLISRVMDKY--QSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSS--ECIGGLLEMLQAFIEPTFGLLQM------ENGLKNNPDTVDDFFRLASRYLDCCPHQLLQS-SLITPIFQCALIAC-SLDHREANSSVMKFFINLLVWGRSNN-------HSRNTECR-PLVVELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQ-QLDEFSSTVLRADTTKAISQALKTFTRLFR---------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q99189-1", "uniprot_id": "MTR10_YEAST", "id": "Q99189-1", "name": "mRNA transport regulator MTR10", "aln": "--MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNALLELNIFAAQTLRNKVTYDLSQLENN-LPQFKDSLLTLLLSHN---QKLIITQLNVALARLAIQFLEWQNPIFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFN-SRIHELIDPIAEDVLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSWSYEFPVEQLLTVQPLINLVFETISNGNESDMEAFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLLPTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAWSVVISKNPD--FFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVLPRYQESRKAYSDIFVKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAIENNNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNLPEQAK--IRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHALMFFCSDCSKLLVGYIDQLINFFLNVQS-SIDIESQFELCQGLSAVINNQPEAKVSVIFQKLVDDNLRQIEALIPQWK-ANPTLLAPQIADKIDLLYALFEELKPRYNYPQQGSEPLLPRIEFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFCEPILPSVAEFLIQGYLTTGFGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQLNDYHEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDIISWGFKTPPISTVSIEIVPDEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISCIVKCLRILTEANNNDATICIDWIYKVVEQLGQVTLNERDNLAKAVVEGLNSKDYRKVREGIRAFVGWYSRKNINSRFE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :. : *:..: . . :::* :* ::*:* :* *.:::* . :. *****:: *: .: :* . .::***:* : . . :*:*** :*:* **: : .*: : :: : :*.:* . :: * * . .: : : :. *:.:* *:: . :* .:* . : : : : . ::. : .: * :*:* * . . *: . .: * *. :: *:*.. ::: : . . * *::: : : :*.. :* :*:.: : * . : : : :*: .: * * ..: . ** :.* :** ::.*::** ::*: .: * :: : .*: ** ** : :**.: :* : :::: : .:.* .: :**:: ::*. : .:*: *: * ::: .: : : .*:: *: :** * . :. ::. *::: .::* :. : . * :* : :: . * :: : :: . :: : *: . . .: . :* .::.. :* : .* :: * : : . :* *:** .: :* .. . . :: .: :: * . ...:*: .. *: :. .. .* : : : . : : *:: ::: *:* * : : * :*.* .:: *::: *: . .**: :* .::: : ::: * . . * * :: :: * *: *: : *. . : : :: * ** ..: :* . :. : : .:: *. : ", "identical_positions": 128, "similar_positions": 331, "identity": "12.99%" }, { "cls_id": "homologset.agr.HGNC:17104", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35158-1", "uniprot_id": "CDON_RAT", "id": "O35158-1", "name": "Cell adhesion molecule-related/down-regulated by oncogenes", "aln": "MHPDLGPLWKLLYV-LVILCSSVSSDLATYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSADALADFDSSTMHVITAEKKNTGFIGCRVPESNPKAEVRYKIRGKWLMYSTGNYIILPSGNLQILNVSSKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDCLSGSNWRRLYSHLATASIDPADSGNYSCVVGNNSSGDVKHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCEVHGNPAPNRTWFHN-AQPIRPSSRHLTEGSVLKITGVIMEDSGLYQCMADNGIG-FMQSTGRLQIEQDSGQRPVIVTAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKSHLFRPGDLDPEPVYLIMSQAGSSSLSIQAVTREHAGKYTCEAVNKHGSTQSEAFLTVVPFETNTKAEPVTPSEASQNDERDPRDGSESGLLNLFPVKVHSGGVELPAEKNAS---VPDAPNILSPPQTHMPDTYTLVWRTGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMKSSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIVINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATSPARSSDMLYLIVGCVLGVMVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGTARINGSVHGGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSLTRTCVEFEHPHHLVNGGAVYTAVPQMDPLECINCRNCRNNNRCFTKTN-----SPLPVVPVVASYPQDGLEMKPLGVMKFPVCPVSTVPDGGQIPEECLKDSVAPAPTQRTCRQDNTSDINSDSTEDTAEFNRG-----------------------DSSGHSEAEDKVFSWSPLILSPVLEDCSEKTAWSPPGPPLDGLSVVLQQAQET", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q32MD9-1", "uniprot_id": "CDON_MOUSE", "id": "Q32MD9-1", "name": "Cell adhesion molecule-related/down-regulated by oncogenes", "aln": "MHPDLGPLWTLLYV-LVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALGDFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLATASIDPADSGNYSCVVGNKS-GDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDVHGNPAPNRTWFHN-AQPIHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGIG-FMQSTGRLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKPRKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFETNTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPAERNAS---VPDAPNILSPPQTHMPDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMVEYTTLSGAARINGSVHGGFLS-----NGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSLTRACVEFEHPHHLVNSGGVYTAVPQMDPLECINCRNCRNNNRCFTKTN-----SPLPVVPVVASYPQGGLEMKPLNAMKVPVCPASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDINSDSTEDTAEFSRG-----------------------DSSGHSEAEDKVFSWNPLILSPVLEDCGEKTARSPPGPPLDGLSVVLQQAQET", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q4KMG0-1", "uniprot_id": "CDON_HUMAN", "id": "Q4KMG0-1", "name": "Cell adhesion molecule-related/down-regulated by oncogenes", "aln": "MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKS-GDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHN-AQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIG-FMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VM64-1", "uniprot_id": "IHOG_DROME", "id": "Q9VM64-1", "name": "Interference hedgehog", "aln": "--------MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPAHPAHPAHP-----SPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAG-----------FKYLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIAR----LELASTSLVDAQESESPLQWRVSAGNSVLWSCGQQVQSNPS---------------ASWSYYRNGVEIKPEFIGTNGNLFLSNVSSESSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIRE---------GSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQ----PPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSN---------------------------NFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQ--------MYP---------------------PTPPNVTRLS----DESVMLRWMVPRNDGLPIVIFKVQYRMVGK----------------------------------------------------------RKNWQTTNDNIPYGKPK-------WNSELGKSFTAS-------------------------------------------------------------------VTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPG---AALDPMPVPELLEIEEYSETAVVLHWS-LASDADEHLITGYYAYYRPSSSAG-EYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTS-----------TTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCRRRNSRSRGNNP-NKPRMAELRDDFVPLGNCSPTKQRQRTRH--------IHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSS------YDYDPTLRRMSSSSLRRSQRTLERAGGSNGSNNGNNN------------------------------------------NLNQSAEAGSIENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV-----------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .** * ::. .* * . .:. : : . *. .*:*. . * : * : * .:*. :.** ::.* : :* * . . .*: .. . *. .*.: .*: * : . . : *:: ..* * . :.. *: .* : : *.** * . :* . : : :*.: .. .** : . : :: ..* : . :.* .. :: :. :* : *::: : * *.*.*. .* . . * . * *:*: . ::* * * *. ***: :. ::.:*: * *: .* . :** :.*.*:*:* *.* * * .... * . . * :::* .*** * * *. * .: : * * * : : *. . *: :: :* * .* : . :: * * . ::.*:** : *:** :.. .. :* . * * ** *.::* :* * * .*:* *:**::.: .:. .*.:* : : : *:. *.: * *:* ::*:*: :.*. :: * *:* ****:.* . . :* : . : . *. *:. * *::*:*.*. .. **** : .*: :.. *. .. . *: ..:*.. ..: : :: .:* .::::::*: *: *::.: .: : * : :::..::* . * : : : . * . * :: ..:: . :. *. :. ::: . : :....: : :: * * *** . .: *.: : . * .: :. .: .. . :. ", "identical_positions": 161, "similar_positions": 317, "identity": "12.48%" }, { "cls_id": "homologset.agr.HGNC:17105", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AAW7-1", "uniprot_id": "D4AAW7_RAT", "id": "D4AAW7-1", "name": "Bestrophin", "aln": "MTVTYSSKVANATFFG-FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKS---PHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKG---YAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS-AARPPYTLAAADYCIPSFLGSTIQMGLSGSDFPAEDWLWNYEKQ-------------------------------GHRHSVMRRVKRFLSTHEHPGSPKRRRSFG--------------------RQASDSSMFFPP---SPARDLLNVPSRNPHRGSPTRKQSHSQEGSPKLHSSMG---------------------ELSTIRETSRTSTLQSLSQQSSVRASPTKMPQVPEVLITAAEAPEAAFASDNHQRDSTTSILSLEFTGVQASGTEQQE-------DPSGKVTPPGDPEPQTISAGTEK-------------------DLFKFEEDLDDDIFPKRWSLPVFRESRHTSLG-NLGPDPVSPENALLL-DTETSSETNGVHPGAGSAVSPDILYLMESLD-KETDILEFNNEHTEEPLKGTPPRPRTWF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6H1V1-1", "uniprot_id": "BEST3_MOUSE", "id": "Q6H1V1-1", "name": "Bestrophin-3", "aln": "MTVTYSSKVANATFFG-FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKS---PHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKG---YVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS-AARPPYTLAAADYCIPSFLGSTIQMGLSGSNFPAEDWLWNYEKH-------------------------------GNRHSVMRRVKRFLSTHEHPGSPRRRRSFG--------------------RQASDSSMFLPP---SPARDLLDVPSRNPHRGSPTRKQSRSQEGSPKLHSSMG---------------------ELSTIRETSRTSTLQSLSPQSSVRSSPTKMPQVPEVLITAAEAP--AFSADSHQHDSTTSILSLEFTGVQPSGTEQQV-------EPSG--TPPGDPNPQTTSASTER-------------------DLFKFEEDLEDDRFPKRWSLPEFLESRHTSLG-NLGPDPVSPRDALLLPDTETPSETNGIHPGAGSALAPDILYLMESLD-KETDILEFNNEHTGESPKGTPQRPRTWF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N1M1-2", "uniprot_id": "BEST3_HUMAN", "id": "Q8N1M1-2", "name": "Bestrophin-3", "aln": "MTVTYSSKVANATFFG-FHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKS---PHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKG---YAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS-AARPPYTLAAADYCIPSFLGSTVQMGLSGSDFPDEEWLWDYEKH-------------------------------GHRHSMIRRVKRFLSAHEHPSSP-RRRSYR--------------------RQTSDSSMFLPRDDLSPARDLLDVPSRNPPRASPTWKKSCFPEGSPTLHFSMG---------------------ELSTIRETSQTSTLQSLTPQSSVRTSPIKMPLVPEVLITAAEAP--VPTSGGYHHDSATSILSSEFTGVQPSKTEQQQGPMGSILSPSEKETPPGGPSPQTVSASAEE-------------------NIFNCEEDP-GDTFLKRWSLPGFLGSSHTSLG-NLSPDPMSSQPALLI-DTETSSEISGINIVAGSRVSSDMLYLMENLDTKETDIIELN-KETEESPK----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VUM7-1", "uniprot_id": "Q9VUM7_DROME", "id": "Q9VUM7-1", "name": "Bestrophin homolog", "aln": "MTVSYTAEVATCSHFGCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFEDIVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQDEHGRLMRRTIMRYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASIVTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQWIDRDIK---HYNNIVSYYFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLIVDEMHNDHPQLVRDQYWDEVFPAELPYAVESD--RAEHPEASTARLGIPKVVPVTMTKSEVSLEN---------------------------------------DFTEFDDEDEYNPEVTIRFARR---------------------------------------------------EFSWSKSSVSVS--------------------------------------------------------------------------------YS---------------------------------------------------YDNQ---------------------SIDTLDEKVDEENEGDTRTLDSRNKDDFDRLKEKRDRERVNRQMQQAALAMELIKGDLASNGGSARSSRTNVPQKNSDVQTDRSYLSQKKRKEEDTDNDKDSDESKK--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4K651-1", "uniprot_id": "A0A0B4K651_DROME", "id": "A0A0B4K651-1", "name": "", "aln": "MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIEVPKNAAMPSTMSSVRIDEMVGNANGDPAAAADAKAPNPVTGQVQVPGADTGVQTVTYDFPKGSPDEEADDASGIHFSAGNGKMRLDSSPSLVSVSGTLSRVNTVASALKRFLSRDDSRPGSATPSQDQPYKFPASASSASLSGAVVGSATSAGKPAGSLRITQQVIEEVDEQATITSMRANDPRPNVMDIFAQTSSGAGTSGPLQPPPAHSEPVDIPSRPPSYNRAQSQYEPNLFPPGGVDALLSTSAPAGGSPLLLSNAATAPSSPVGESSKSLYDPQKGASRETERPDAPQVFRWFVTPVESMDLRSSTDLLGDAAVQPEDEGDDFDKLKAEREKEKLMRQQKNLARTISTAPGMEATAVPMVPMVPVNVAVQQAQLQPVASSADLLAGGDQFSNSTMKSEDAINGS", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::*:.:**.. ** * :**::**.****::: :::.* : : ::** * .:* ** : **. * : **::******* ::: *****: .:**** : . :*: *:*.*::**::***:**** * ::: :*. : :*** ::::*.*::. :* .::. :. *:*:*::* ..: *:**:**** *.. ::::: *:*::*. *.:*: ** :.:*************::*.:. :*:*: * : :. *.*:*: *:***: ******* ** ***:****** ** :******* * ***** . *:: :* ***: . . **:: : ** :: :. .. . . .* : : . .* . . : . : : . . . * : : : . . . :: .:: : . ", "identical_positions": 153, "similar_positions": 157, "identity": "19.52%" }, { "cls_id": "homologset.agr.HGNC:17106", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8NFU0-1", "uniprot_id": "BEST4_HUMAN", "id": "Q8NFU0-1", "name": "Bestrophin-4", "aln": "MTVSYTLKVAEAR-FGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVH----GVD-QRGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESL--KSDFN-KYWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPPAEKDQYWDEDQPQ-PPYTVATAAE-----------------------------------------------------------------SLRP-----SFLGSTFNLR----MSDDPEQSL----------------------------------QVEASPGSGRPAPAAQT---PLLGRFLG------------------------------VGAPSPAIS---LRNFGRVRGTPRPPHLLRFRAEEGGDP----------EAAARIE--------EESAE-SGDEALEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZX44-1", "uniprot_id": "D3ZX44_RAT", "id": "D3ZX44-1", "name": "Bestrophin", "aln": "MTVSYTLKVAEAR-FGAFSGLLFRWRGSIYKLLYREFLLFCALYATLNITYRLLLTQEQKRIYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVH----GVD-QSGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESL--KSDFN-KYWVPCVWFTNLAAQARRDGRIRDDIALCLILEELNKYRAKCGMLFHYDWISIPLVYTQVVTIAVYSFFTLSLIGRQFVESDK-------------ESSPAPWYLDMFVPLTTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNQLIDRNFQVSLLSVDDMYQNLPPTEQDLYWDEARPQ-PPYTVATAAE-----------------------------------------------------------------SQRP-----SFMGSTFNLR----MSDDPEQCL----------------------------------QVEASRRFDLPAPVTQTSQTPLLGRFLA------------------------------ARAPSPAVS---LQNL-------RTSHLLHLRP--GGE-----------EAEGRIE--------EAVDEGSENEAMEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VRW4-1", "uniprot_id": "Q9VRW4_DROME", "id": "Q9VRW4-1", "name": "", "aln": "MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMS-KYWMPLVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAALLGRQMLPNVLD--------------RSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLPL----------------------------TILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIKQNSKLNGLN--VNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPPGMYPSSYAPDTLLHQESGQVLGTLLLSPIKEMDSSSSNNTLIPGHPATAALAASMKEGFTPSSIPAATNITTLSFPFSVTSTG----------------GETMPTGTLSILPISANAQLPTITTTASGYDPNDVITTIPVSLSIQRSPSALSIVELTGADVQDGYSNSGSSNGNGGITTTALLSVKPLNGNQNISRNNSFNLSLNLQDPQQRSSMRSAGPTGTVDNSGTMPIPQRSGGLETGEVGGSSAPSTLAKHKPEQKTGEVYV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VUM7-1", "uniprot_id": "Q9VUM7_DROME", "id": "Q9VUM7-1", "name": "Bestrophin homolog", "aln": "MTVSYTAEVATCSHFGCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFEDIVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVR----GQD-EHGRLMRRTIMRYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASIVTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQWIDRDIK---------------HYNNIVSYYFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLIVDEMHNDHPQLVRDQYWDEVFPAELPYAVESD-------------------------------------------------------------------RAEHPEASTARLGIPKVVPVTMTKSEVSLEN---------------------------------------DFTEFDDEDEYNPEVTIRFARR---------------------------------------------------EFSWSKSSVSVS--------------------------------------------------------------------------------YS---------------------------------------------------YDNQ---------------------SIDTLDEKVDEENEGDTRTLDSRNKDDFDRLKEKRDRERVNRQMQQAALAMELIKGDLASNGGSARSSRTNVPQKNSDVQTDRSYLSQKKRKEEDTDNDKDSDESKK------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4K651-1", "uniprot_id": "A0A0B4K651_DROME", "id": "A0A0B4K651-1", "name": "", "aln": "MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVH----GQD-ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVG------------NTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERF-----------------------------------------------------------------RENHPEPSTAKIEVPKNAAMPSTMSSVRIDEMVGNANGDPAAAADAKAPNPVTGQVQVPGADTGVQTVTYDFPKGSPDEEADDASGIHFSAGNGKMRLDSSPSLVSVSGTLSRVNTVASALKRFLSRDDSRPGSATPSQDQPYKFPASASSASLSGAVVGSATSAGKPAGSLRITQQVIEEVDEQATITSMRANDPRPNVMDIFAQTSSGAGTSGPLQPPPAHSEPVDIPSRPPSYNRAQSQYEPNLFPPGGVDALLSTSAPAGGSPLLLSNAATAPSSPVGESSKSLYDPQKGASRETERPDAPQVFRWFVTPVESMDLRSSTDLLGDAAVQPEDEGDDFDKLKAEREKEKLMRQQKNLARTISTAPGMEATAVPMVPMVPVNVAVQQAQLQPVASSADLLAGGDQFSNSTMKSEDAINGS----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VUM6-1", "uniprot_id": "Q9VUM6_DROME", "id": "Q9VUM6-1", "name": "Bestrophin homolog", "aln": "MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIH----GSD-DRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSD---------------EDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKM-------------------------------------------------------------------RQNPPAASTAYMESQSKLQKRHESAMSTLSTR--------------------------------------SRNNFRQNFLGRPSATGSYSDS--------------------------------------------------IQMEDGPSRVTFS--------------------------------------------------------------------------------------------------------------------------------------ENQ-------------------------FDLPHDEANSSHKPSQSTIDFNDLIEQRRRERRERIRHRFLDMQSTHLRHDTSGAPYTITVLRPPSDETLSESQEAGDRAQQDPSGSKEPPPNKTEKQD----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::*: .*. :. * :* :**.*:**::: ::: : : : : ** : : : : * . **:******:* ::: ***.** :* ** : :*: : * : : .*::**.::** *. .:.: :* : :*** ::::.*:: .* . :::: *:*:* ** :.: :**::. * .* : :: **.. * . *: ** :.:*********:. *::* . .*:* :.*: : *:*.*: ******* :* ***:****:* * ::**:: .: **:*:.: * :* **: * **: . : . . . ", "identical_positions": 106, "similar_positions": 121, "identity": "12.18%" }, { "cls_id": "homologset.agr.HGNC:17107", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A3A7-1", "uniprot_id": "D4A3A7_RAT", "id": "D4A3A7-1", "name": "Bestrophin", "aln": "MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRD-----DRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYN---KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQG---YKDHTLDLCIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEA------------RAPYTAATAFLLQQPS----------------------------------------FQGSTFDIALAKEDMQ---------------------------------------FQRLDVVDGPLGEAHGDFLQR---------------------------------------------------LLPAGAGTVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGRRLSLLRRKNSCVSEASTAASCSCAGAADGGGVECGCGDPLLDPSLREPELEPPACPEPPAPIPGPTPEPFTAVSIPGPRAPAPPWLPSPIGEEEESPA--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGM5-1", "uniprot_id": "BEST2_MOUSE", "id": "Q8BGM5-1", "name": "Bestrophin-2", "aln": "MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRD-----DRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYN---KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQG---YKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEA------------RAPYTAATAFLLQQPS----------------------------------------FQGSTFDIALAKEDMQ---------------------------------------FQRLDGVDGPLGEVHGDFLQR---------------------------------------------------LLPAGAGSVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELEPPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFU1-1", "uniprot_id": "BEST2_HUMAN", "id": "Q8NFU1-1", "name": "Bestrophin-2a", "aln": "MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRD-----DRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYN---KYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQG---YKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAAEA------------RAPYTAATVFQLRQPS----------------------------------------FQGSTFDITLAKEDMQ---------------------------------------FQRLDGLDGPMGEAPGDFLQR---------------------------------------------------LLPAGAGMVAGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------PLGRRLSFLLRKNSCVSEASTGASCSCAVVPEGAAPECSCGDPLLDPGLPEPEAPPPAGPEPLTLIPGP-VEPFSIVTMPGPRGPAPPWLPSPIGEEEENLA--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VUM7-1", "uniprot_id": "Q9VUM7_DROME", "id": "Q9VUM7-1", "name": "Bestrophin homolog", "aln": "MTVSYTAEVATCSHFGCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFEDIVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQD-----EHGRLMRRTIMRYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASIVTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQWIDRDIK---HYNNIVSYYFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLIVDEMHNDHPQLVRDQYWDEVFPAELPYAVESD--RAEHPEASTARLGIPK----------------------------------------VVPVTMTKSEVSLEN---------------------------------------DFTEFDDEDEYNPEVTIRFARR---------------------------------------------------EFSWSKSSVSVS--------------------------------------------------------------------------------YS---------------------------------------------------YDNQ---------------------SIDTLDEKVDEENEGDTRTLDSRNKDDFDRLKEKRDRERVNRQMQQAALAMELIKGDLASNGGSARSSRTNVPQKNSDVQTDRSYLSQKKRKEEDTDNDKDSDESKK------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A0B4K651-1", "uniprot_id": "A0A0B4K651_DROME", "id": "A0A0B4K651-1", "name": "", "aln": "MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQD-----ERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWDEVFPNELPYTIAAERFRENHPEPSTAKIEVPK----------------------------------------NAAMPSTMSSVRIDEMVGNANGDPAAAADAKAPNPVTGQVQVPGADTGVQTVTYDFPKGSPDEEADDASGIHFSAGNGKMRLDSSPSLVSVSGTLSRVNTVASALKRFLSRDDSRPGSATPSQDQPYKFPASASSASLSGAVVGSATSAGKPAGSLRITQQVIEEVDEQATITSMRANDPRPNVMDIFAQTSSGAGTSGPLQPPPAHSEPVDIPSRPPSYNRAQSQYEPNLFPPGGVDALLSTSAPAGGSPLLLSNAATAPSSPVGESSKSLYDPQKGASRETERPDAPQVFRWFVTPVESMDLRSSTDLLGDAAVQPEDEGDDFDKLKAEREKEKLMRQQKNLARTISTAPGMEATAVPMVPMVPVNVAVQQAQLQPVASSADLLAGGDQFSNSTMKSEDAINGS----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VUM6-1", "uniprot_id": "Q9VUM6_DROME", "id": "Q9VUM6-1", "name": "Bestrophin homolog", "aln": "MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSD-----DRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSD---EDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKM--RQNPPAASTAYMESQS----------------------------------------KLQKRHESAMSTLSTR--------------------------------------SRNNFRQNFLGRPSATGSYSDS--------------------------------------------------IQMEDGPSRVTFS--------------------------------------------------------------------------------------------------------------------------------------ENQ-------------------------FDLPHDEANSSHKPSQSTIDFNDLIEQRRRERRERIRHRFLDMQSTHLRHDTSGAPYTITVLRPPSDETLSESQEAGDRAQQDPSGSKEPPPNKTEKQD----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VRW4-1", "uniprot_id": "Q9VRW4_DROME", "id": "Q9VRW4-1", "name": "", "aln": "MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSP-MSKYWMPLVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAALLGRQMLPNVLD--RSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIKQNSKLNGLN--VNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPPGMYPSSYAPDTLLHQESGQVLGTLLLSPIKEMDSSSSNNTLIPGHPATAALAASMKEGFTPSSIPAATNITTLSFPFSVTSTGG-------------------ETMPTGTLSILPISANAQLPTITTTASGYDPNDVITTIPVSLSIQRSPSALSIVELTGADVQDGYSNSGSSNGNGGITTTALLSVKPLNGNQNISRNNSFNLSLNLQDPQQRSSMRSAGPTGTVDNSGTMPIPQRSGGLETGEVGGSSAPSTLAKHKPEQKTGEVYV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**::*:..*.. :. * :* **.*:**::* :*: :: : : ** : : *: : * . . **:******:* ::: ***.** :* ** : :: : . : : .*: **.::** *. .: : :* : :*** ::::.*:: .* . :: :: *:*:* ** :.: :**::. * .: :: :: **. :* . *: ** :.:*********:. *::*: . :*:* .*::: *:*.*: ******* ** ***:****:* *:::**:: .: ****:.: . * :* **: . . * . :. . . . : . . . . .. . . . . . ", "identical_positions": 106, "similar_positions": 137, "identity": "12.73%" }, { "cls_id": "homologset.agr.HGNC:17108", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZLL7-1", "uniprot_id": "D3ZLL7_RAT", "id": "D3ZLL7-1", "name": "", "aln": "--------MEP-----RGCFALWVLLLAQLSEQQTPACALGAAAAATER------------------------------LGDPHPPSSS-GSDWLETSEYDLVSAYEVDHSGDYVSYDIMHHQRRRRR-AVTQSKGDALHLRLK----GPRHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPAEENCFYQGSLRSQGNSSVALSTCQGLLGMIR------------TKDADYFLKPLPPQLTSKLNRSAQGGSPSHILYKRSTEHQAPRENEVLMITRKRDLARTHLHHDNFHLGLSRKQHFCGRRKKYMPQPPDDNLYILPDEYKPSSRPKRSLLKSHRN------EELNVETLVVVD-------RKMLQSHGHENITTYVLTILNMVSALFKDGTIGGNINIVIVGLILLEDEQP-GLAISHHADRTLTSFCQWQSGL---MGKDG--ARHDHAILLTGLDICSWKN----EPCDTLGFAPISGMCSKYR-------SCTVNEDSGLGLAFTIAHESGHNFGMVHDGE----------GNMCKKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMWCRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGVSHRDRLCTNPRPSHGGKFCQGSARTLKLCNSQKCPLDSVGFRAAQCAEYNSKRFRGWLYKWTPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCEKVGCDNVLGSDATEDSCGVCQGNNSDCVMHRGLYSKNHPTNQYYHVVTIPSGARSIHIYETNISTSYISVRNSVKKYYLNGHWSVDWPGRYKFSGTTFNYRRSYKEPESLTSTGPTNETLIVELLFQGRNPGVAWEFSVPRSGSKRTPPPQPSYSWAILRSECSVSCGGGKMSSKAGCYRDLKVLVNASFCNPKTRPVPALVPCKVSACPPSWSVGNWSTCSRTCGGGTQSRPVHCTRRAHYREESISASLCPQPAPPLHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTSEPKPRTHQVCLLKRCHKHKKLQWLVSAWSPCSATCQRGTQHRVLRCAEKYVSGKYRELASKKCLHLPKPDLELERACGLIPCPKHPPYAASGPPRGSWFASPWSLCTASCGGGVQRRTVQCLLGGQPASDCFLHEKPETSTACNTHFCPIAEKRDTFCRDLFHWCYLVPQHGMCSHRFYSKQCCNTCSKSNL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q69Z28-1", "uniprot_id": "ATS16_MOUSE", "id": "Q69Z28-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 16", "aln": "--------MES-----RGCAALWVLLLAQVSEQQTPACALGLAAAASGS------------------------------PEDPQPPPFS-GSSWLETGEYDLVSAYEVDHRGDYVSHDIMHYQRRRRRRAVTQPGGDALHLRLK----GPRHDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPPEENCFYQGSLRSQGNSSVALSTCQGLLGMIR------------TKDTDYFLKPLPPHLTSKLNRSAQGDSPSHVLYKRSTERQAPRENEVLMITRKRDLARPHLHHDNFHLGPSQKQHFCGRRKKYMPQPPNDDLYILPDEYKPSSRHKRSLLKSHRN------EELNVETLVVVD-------RKMMQSHGHENITTYVLTILNMVSALFKDGTIGGNINIVIVGLILLEDEQP-GLAISHHADHTLTSFCQWQSGL---MGKDG--TRHDHAILLTGLDICSWKN----EPCDTLGFAPISGMCSKYR-------SCTVNEDSGLGLAFTIAHESGHNFGMVHDGE----------GNMCKKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMWCRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDRLCTNPRPSHGGKFCQGSTRTLKLCNSQRCPLDSVDFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCERVGCDNVLGSDATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQYYHMVTIPSGARSIHIYETNISTSYISVRNSLKRYYLNGHWSVDWPGRYKFSGATFNYKRSYKEPENLTSPGPTNETLIVELLFQGRNPGVAWEFSLPRSGAKKTPAAQPSYSWAIVRSECSVSCGGGKMNSKAGCYRDLKVPVNASFCNPKTRPVTGLVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPVRCTRRAHYRDESIPASLCPQPEPPIHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTSEPKPRTHEICLLKRCHKHKKLQWLVSAWSQCSVTCQGGTQQRVLRCAEKYISGKYRELASKKCLHLPKPDLELERACGLIPCPKHPPFDASGSPRGSWFASPWSQCTASCGGGVQRRTVQCLLRGQPASDCFLHEKPETSSACNTHFCPIAEKRGTFCKDLFHWCYLVPQHGMCGHRFYSKQCCNTCSKSNL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TE57-1", "uniprot_id": "ATS16_HUMAN", "id": "Q8TE57-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 16", "aln": "--------MKPRARGWRGLAALW-MLLAQVAEQ-APACAMGPAAAAPGS------------------------------PSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQR--RRRAVPVSEVESLHLRLK----GSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIR------------TEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRN------EELNVETLVVVD-------KKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQP-GLVISHHADHTLSSFCQWQSGL---MGKDG--TRHDHAILLTGLDICSWKN----EPCDTLGFAPISGMCSKYR-------SCTINEDTGLGLAFTIAHESGHNFGMIHDGE----------GNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK--LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSKSNL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W1Z6-1", "uniprot_id": "Q9W1Z6_DROME", "id": "Q9W1Z6-1", "name": "", "aln": "MTVAAIGSNRHRRLALIVLTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSP-AAALDLCEPGNVRGVFQ------------QNGSDLVIHPLP----------ARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADP--LHYDHALVLTGLDLVTYDKGK--ANSQVVGMATVKGMCTSIY-------SCTINEAKHFESVFVVAHEIGHNLGMRHDAK----------EISCDPT-MHIMSPKLG--SGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTS--HPALEGTECGPNMWCRGGTCEARSSK-----QGSYSALKSWPPEH---------------IPEATHEKIIRHEPNRIPPLLHDYNP---------------MDNELPGSPSNWGEWSEPSACESGCLYG----------QSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPS-----------------TLDASCKIFCR--------------TRTNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSN----------------FFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKP----------QKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPP----------GTRCSPVGKRYCVYG------------RCLEFGDDDLPLDKTHISLG-------QLRTRRKRSSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADELSSKSR--------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "B7YZP6-1", "uniprot_id": "B7YZP6_DROME", "id": "B7YZP6-1", "name": "", "aln": "MSSPLVLFTALLLVSSTICQGLPDLHKQMTPEQLQSVFHVDTHDAVPHY------------------------ELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELS------PNPEESHHIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRRSAPSSPDFEDLNDEDEGALDGEPQVAESRTRSRRQAPYIIYP-----------EVLVIVDYDG-----YRLHGGDNLQVKRYFISFWNGVDLRYR-LLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMS-DLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAP----HEDSALGRSLPGTLLSLDAQCRRDRGTYACFK----DERVCAQLFCFDAQTGYCVAYRPAAEGSACGNGYHCLDGRCTPLPSNIIPDYGHNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVEDQDEGTTSSEEQ-------------------EDNKIEQSSAAGGAAAQSTTTARSTTTT-----------TVRTTSTTTTTAKPKSKSFGYLHRSLPERQWMQDNGVLVTTRISSSVSSSSSGSSSGEAAATSTRRPTTTTTTQT-------------------PNLFQIYTH-------------ELRKQIEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLVQKSLTN--------------YSVTSSSSSTSNGAKQQPPSNKDENQRQQQQQQQAQQQLQDGLP-------------------DEENEATAGIQSNEAIERQKRKFPTTPTAATSAAQKSATPATPATSATSARPTPTTAKPITTSSFLDAYFKKLQALHDAGSASSSTTTTTTTSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRSSLKAYKTSSSSSNNSSSQTQQQQQQQQQQ-----------------------------------------------------------------YATNYIGDTTNNQPAVLDNSGSASSTTETAKKPKIKTQKLIRRTRVMQTQTQTI------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : ... . . . .. : :: . : . . .:.*: : *. . *:: : : * . : ::: * .::*** .. *::*: .. .: * : . : . . * :* *. :.** : . :: :.::: * *. :: * .*.: : : : .. :. . . . . . : : :* *: :* **: . . *:* : * * . ::: : :. *** ** :* **.. * *** * . . ** *: :..** * ** : . . *** . : ** * :* * * ** **: ** . * .* * .: : . . : ...: :: : : . :. . .:. . : . : . : . : .. : : : .: .: .. : * .. . ..* . . .: : : . . * . . :* . . .. *. . : . . ... . : :::: : . . : . . .. . :: . . * . : .* .: ", "identical_positions": 76, "similar_positions": 208, "identity": "5.74%" }, { "cls_id": "homologset.agr.HGNC:17109", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZWR9-1", "uniprot_id": "A0A8I5ZWR9_RAT", "id": "A0A8I5ZWR9-1", "name": "", "aln": "MCDGTLLPPLVLS-LLLLVWGLDPGTVVGDAAADVEVVLPRRLRPDDVHLQLLPGAAGLRQWRRPRASPGDPRAGPGERALLLHLPAFGRDLYLQLRRDLRFLSPGFEVEEAGVSGRSGHPAELCFYSGQVLGHPGSLVSLSACGAAGGLVGLIQLEQELVFIQPLNNSGGPFSRREHLIRRKWSSTSGLATKVEGPRQHCKVVTEEK-PRKGKLSWDWRERRNAIRLTNEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLITDPRSQHALRLPHKLPGMHYSANEQCQILFGTNATFCKNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWSAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCQGASVEHAACENLPCPKGVPSFRDQQCQAHDRLSSKKRGLLTAMVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVYGRCQKIGCDGIIGSAAKEDRCGVCSGDGKTCRVVKGDFSHSRGTALKDSSKRSINSDWKIELPGEFQIAGTIVRYVRRGLWEKFSAKGPTTVPLHLMVLLFHDQNYGIHYEYTIPVNQSTENQSEPAKPQDALFLWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVAGQWSPCSATCEKGIQHREVTCVYQLQNGTHVTTRPIYCSEPRPTPVQSCEGQDCLSIWEASEWSECSANCGKGIRKRTVTCTNSQGKCDAATRPKAEEACEDYSGCYEWKTGDWSKCSSTCGKGLQSRVVQCMHKVTGRHGSECPTLSKPAAYRQCHQEVCNEKINVNTITSPRLAALTYKCTRDQWTVYCRVIREKSLCQDMRWYQRCCQTCRDFYANKMRQPPSPPSL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "D3YX90-1", "uniprot_id": "ATS17_MOUSE", "id": "D3YX90-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 17", "aln": "MCDGTLLPPLVLS-LLLLVWGLDPGTAVGDAAADVEVVLPRRLRPEDVHLQLLPGAAGLRRWRRPRASPGGHRAGQGERALLLHLPAFGRDLYLQLHRDLRFLSPGFEVEEAGVSGRSGHPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLEQEQVFIQPLNSSGGPFIGREHLIRRKWASTPSPATEVEGPRQRCKVVTEKK-PRKDHLSRDWRERRNAIRLTNEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHRSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLITDPRSQHALRLPHKLPGMHYSANEQCQILFGTNATFCKNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSLWSAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCQGASVEHAACEKLPCPKGVPSFRDQQCQAHDRLSSKKRGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYEADLCVYGRCQKIGCDGIIGSAAKEDRCGVCSGDGKTCRVVKGDFSHSRGTALKDSSKRSINSDWKIELPGEFQIAGTTVRYVRRGLWEKFSAKGPTTVPLHLMVLLFHDQNYGIHYEYTIPVNQSSENQSEPAKPQDALFLWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSATCEKGVQHREVTCVYQLQNGTHVTTRPIYCSEPRPTPVQSCEGQDCLSIWEASEWSECSANCGKGIQKRTVTCTNSQGKCDASTRPKAEEECEDYSGCYEWKTGDWSKCSSTCGKGLQSRVVQCMHKLTGRHGSECPTLSKPAAYRQCHQEVCNEKINVNTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYADKMRQPPSPPSS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TE56-1", "uniprot_id": "ATS17_HUMAN", "id": "Q8TE56-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 17", "aln": "MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPP-PNS-", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "****:*******. ************.************* *:**:**** **.*.* *: ****:.*. ** ********************:******* ********.: * *:*********:************************** ** *:*****.* *** *********: *.. :::.: *.* ***:**:* * .: * ************.****************************************:*************************************************************.* ******************************************************************************************************************:*******::********************** *****:*********************************************************** *.******************************** *******.**:******:***************.**:*****:************************************:****:*:*****************************::*******:********.* ******************* ***********:******.:************:********:***:::****** ****:**:****************************************************** ********:* ***********.*****************:***:**. ***:.*******************:***.****: ****:**********:***:*** ****************.*******************:*********:*****.****:*****::**.******************************.********************:****** * * ", "identical_positions": 970, "similar_positions": 85, "identity": "88.42%" }, { "cls_id": "homologset.agr.HGNC:1711", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LY89-1", "uniprot_id": "A0ABK0LY89_RAT", "id": "A0ABK0LY89-1", "name": "", "aln": "------------------------------------------------------------------MCFGPCPSSRGDRVSGPRAQSGVAFVPGAGARRALGLFPRHFPVTFQRGGQFRGGPCPRPLHKGPAQPPATALCQPRRCPFRATMRGVSCHLLLVLCFVPNLSGVGTQKASG--CARWCPPNSECESNRSCKCKPGFNSSSPDGLITNPAQSCEDINECIQT-DNLCGPYAMCMNSEGSYYCVCNLGYKLLSGAESFTNKSENTCQASVDTGMIPVPSSIHTVPTAR-KLPEQPTTVHPRTQLGDSGERTPKDVNECTSGQNQCHQSTHCINKMGGYSCICRRGWKPAPGSPNGPVNTVCEDVDECSSGQHQCHSSAICKNIPGSYKCRCPPGWIAIPRDKPN--NTVCQEP-HFPTWTLLPTAHSQALLSFSVEVQNLLRDFNPATVNYT-----------------------------------------------IQKLIEAVDKLLEMPMDIGTQTQQV----------ATQLLSNLEQSLRTLAQFLPKGPFTYKSP-SNTELALMVKEQDNKDVTTVHHSQ----AWMQLDWAVTAGAKSSENGYSVAGILSSPNIQKLLANTSLNLE-----------QKRDTLEDLYGSPVQSVTLTFLSNINAIFLTNTDTEKLASDVTFKFNLTSVKSLKA-------------REELMCAYWKSHDNGSGSWATDGC----SMNDTGFCHCNHLTSFAVLMAQYHVQD----------PRLELITKVGLLLSLVCLLLCILTFLLVKPIQSSRTMVHLHLCICLFLGSVIFLVGVENEGGEVGLRCRLVAMLLHFCFLAAFCWMALEGVELYFLVVR----VFQGQGLSTWHRCLVGYGVPLLIVAIS-AAARMDGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSE--INPNMKKLRKARVLTITAIAQLLVLGCTWGFGLFLF-----NPH-STWLSYIFTLLNCLQGLFLYVTLCLLNKKVREEYWKWACMVTG-NKYTEFTSSTTGTGTSQTRTLRPSESGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0M6-1", "uniprot_id": "AGRE5_MOUSE", "id": "Q9Z0M6-1", "name": "Adhesion G protein-coupled receptor E5", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------MRGVRCPGLLVVCILLSLSGAGTQKAESKNCAKWCPINSKCVSNRSCVCKPGFSSEKE--LITNPAESCEDINECLLP-GFSCGDFAMCKNSEGSYTCVCNLGYKLLSGAESFVNESENTCQASVNTGTTPVPSRIHTVTTAPGNLPEQTTTVH-QTQMGDSEERTPKDVNECISGQNHCHQSTHCINKLGGYSCICRQGWKPVPGSPNGPVSTVCEDVDECSSGQHQCHNSTVCKNTVGSYKCHCRPGWKPTSGSLRGP-DTICQEP-PFPTWTLLPTAHSQTLLRFSVEVQNLLRDFNPATVNYT-----------------------------------------------IQKLIEAVDKLLEDPMET--QTQQV----------AAQLLSNLEQSLRTLAQFLPKGPFTYTSP-SNTELSLMVKEQDNKDVTTVHHGQ----TWMELDWAVTAGAKISENGSSVAGILSSPNMEKLLGNTPLNLE-----------QRRASLEDFYGSPIPSVSLKLLSNINSVFLTNTNTEKLASNVTFKFDFTSVESIEP-------------RHELICAFWKAH-NGNGYWDTDGC----SMNGTGFCHCNHLTSFAILMAQYHVQD----------PRLELITKVGLLLSLICLLLCILTFLLVKPIQSSRTMVHLHLCICLFLGSIIFLVGVENEGGEVGLRCRLVAMMLHFCFLAAFCWMALEGVELYFLVVR----VFQGQGLSTWQRCLIGYGVPLLIVAISMAVVKMDGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSE--INPNMKKLRKARVLTITAIAQLLVLGCTWGFGLFLF-----NPH-STWLSYIFTLLNCLQGLFLYVMLCLLNKKVREEYWKWACMVTG-SKYTEFNSSTTGTGTSQTRALRSSESGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P48960-1", "uniprot_id": "AGRE5_HUMAN", "id": "P48960-1", "name": "Adhesion G protein-coupled receptor E5", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------MGGR---VFLAFCVWLTLPGAETQDSRG--CARWCPQNSSCVNATACRCNPGFSSFSE--IITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQN--PRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM-TFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT-----------------------------------------------IQNVIKLVDELMEAPGDVEALAPPVRH------LIATQLLSNLEDIMRILAKSLPKGPFTYISP-SNTELTLMIQERGDKNVT-MGQSS----ARMKLNWAVAAGAE--DPGPAVAGILSIQNMTTLLANASLNLHS----------KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVED----------WKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVR----VFQGQGLSTRWLCLIGYGVPLLIVGVS-AAIYSKGYGRPRYCWLDF-EQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSE--INPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIF-----DDR-SLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "R4GDT3-1", "uniprot_id": "R4GDT3_DANRE", "id": "R4GDT3-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEPKWALLLGFILSFRSFTTEG----------SSYTSDKGLS---SVIPAVCHG---VQCNNGP----TTASADPDLEISG----------------------------------------------------------DTDSEISG--DSDLEIS------------SQPYLTMST-------QASLDITASSFP----AHRQDVIRATQTSETTSQNAFVSP-KGAAEQTEIECDQFKSKPDEDHTPEKLNQMMSLLKDSCESLN---DPVEKHFN-----------------------------------------------AEELLENLCNSTDDLLLEGKVADGEN---------LSVFLDMVENSMRLIGPQLKDPVTKMETQNTYAEVALTRNQTPPSGSVTLSTDS----ALFSTSWETVVGKA--YSGFAFVALFSYKDMNSSSDLSHKTSR-----------TLQEDSRKRLHVDEKKITYQLNSKVVTAVVSNPDTKKLSDLMMLTFTHEEERAESG-------------GVAYTCVYWNES---EKVWSGRGCVKEWSNSTHTVCHWSHLSSFAVLMALYPVQDT---------FASVLITRVGLVLSLLCLFLCILTFRFCRSIQGTRNSIHLHLSVCLFIADLVFLCGISSTHN--QVACAIVAGLLHFFFLSAFCWMLLEGVQLYRMVVL----VFHTT-LKHLYLYAVGYGVPLVIVSIS-AITFPKGYGTNKHCWLSL-EGYLILSFFAPVCIIVILNIIVFIITVWKLALKFSS--LNPDLSKLHKIRSFLATAVAQLCVLGGSWVFGFFLF-----QKNGTEVMLYLFIILNSLQGALIFIMHCLLSKQVRVEYHSLFVRMCPYKKKGDYSVS-TEPSHSSQKRLQSDQSTGESQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B737-1", "uniprot_id": "A0A8M2B737_DANRE", "id": "A0A8M2B737-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELKWAFILGLFLPSCSGCALG----------YKFVKRKCVDEDECETPGMCGD---AQCVNTDGSYYCTCAAGFKMSQTGPCKDINECLEDELICPAQMRCENTFGSYVCVCPTGHQW-------------KNEAECEDEDECLSS--PCGLHRSCFNTPGSFVCKCSPGFRELEG-------GMCADINECSESPDVCGTNGDCINNPGGFSCRCHQGFTNYGNNQSKCIEMSCDQFKPEPDAGNTPEKLKHLMSLLMNSCKSLN---DPHGEHFT-----------------------------------------------AEKLLENLCNSTDDLLSEGNVADGET---------LSVFLDAVENSMRLIGPQLKDPVTKMETQNTYAEVAVTRNQTPPSGSVTLSTGS----AHFNTSWETVVGKS--YPGFAFVALVSYKDMNSSSDLFNSMAR-----------EKSD-------VKEKQITYKLNSKVVTAVVSNPDTKHLSKPVTLIFTHEEKRAESE-------------GVAYSCVYWSES---ERGWSGRGCELAWSNSTHTACSCSHLSSFAVLMALYPVEDT---------FELVVITRVGLVLSLICLILCILTFRFCRSIQGTRNSIHLHLSVCLFIADLVFLCGISSTHN--QVACAIVAGLLHFFFLSAFCWMLLEGVQLYRMVVL----VFHTT-LKHLYMYAVGYGVPLVIVSIS-AIAVPKGYGTDRHCWLSL-EGYLILSFFIPVCIIVILNITVFIITVWKLALKFSS--LNPDLSKLHKIRSFLATAVAQLCVLGGSWVFGFFLF-----QKNGTEVMLYLFIILNSLQGALIFIMHCLLSKQVRVEYRSLFMRMCSNKKKGDYSVSSTEPSHSSQKPLQIDQSTGESTI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z7G7-4", "uniprot_id": "LPHN_DROME", "id": "A1Z7G7-4", "name": "Latrophilin Cirl", "aln": "MLPTILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGAT-STTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTN----------------PTCVFWNYI---DHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTET--SIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAIS-LVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRSTGHASPTSSAGSTHLIFAHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYYNQGSVGGADGGPVYEEILSNRNSDVQHYEVGDFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYGGGSLSGGSVSSRSQQQQLKKQQQQQSLAQQRSARRCTADDDDDEDEEEDEEATAAEQLHDSVCDEDEEEDESDLEDDAHGLPPQSDERMRRLMAMQDEDFKRRFQRQLRKHGAPLDYGALPPGAGPQPEHNGAVFGVSGGVGEGSLRGAFRQQQQQALNAKSPGGRLAVNELFGHGNSGPPLPPANQTPAQKRQQLQKLSPQSTTSSSSHTSHSNPNPHPHQLTHPHPHQHPPHHQQRHLSAMLDENNTVRCYLEPLAK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . . : . . . . . . : . . . . . .: . : .. :::. : : . : : :* :* :. : . . : .. . . .. : . .. * : : : . * : : : : .* . : : : . *.:*. * ** : * .**:.**:** .: : :*: : :. : * *.: ::.:*. :: : :**: . :** *:.. : * ::: :** :*:. .*: *... * :. : . :.**:.* :*.:* . * :* * : : :* ** .:.. . : : * . : .:* . * :.. * :*. * . * : : : * * :* * * ::: *: .:::* ** . * . : .. . . ", "identical_positions": 61, "similar_positions": 164, "identity": "3.52%" }, { "cls_id": "homologset.agr.HGNC:17110", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z8G4-1", "uniprot_id": "D3Z8G4_RAT", "id": "D3Z8G4-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 18", "aln": "----MECALLFLCALRA----AGPGPPWGPAGLARLAKALQLCCLCCASVAVALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHN-RKRRSAHGASSSVHYRFSAFGQDLHLELKP-SALLSSHFIVQVLGKDGASETREPAVVQQCLYQGFIRNDSLSSVAVSTCAGLSGLIRTRDNEFLISPLPQLLAQQHN------YSLPAGHHPHVLYKRTAEKR--------------VRRYQDYPASQRTYPGHSPSHTPPASQSQETEYRHRRWQKQHFCGRRKKYAPKPPAEDAYLRFDEYGGAGRPRRSARKSQK--GLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTIGSDINIVVVSLILLEDE--PGGLLINHHADQSLNSFCQWQSALVG---KNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNPCRKAEG---NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYPDKLPGQIYDADTQCKWQFG--AKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVRLGDLGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCHENSLDFRAQQCAEYNNKPFRGWLYRWRPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICEPVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLSQHKAN--EYYPVVTIPAGARSIEIQELELSSSYLAVRSLSQ--KYYLTGGWNIDWPGDFTFAGTTFEYQRPFNRPERLYAPGPTNETLVFEILTQGK--NPGITWKYALPKVMNVTQPAAKRHHHTWRTVQSDCSVTCGGGYISIKAICLRDQNTQVNSSFCSVRTK---PATEPKLCNAFSCPAYWLPGEWSTCSKSCAGGQQSRKIRCVQKKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWSPGPWSQCSKTCGRGVRRREVLCTS----PAAETLPESLCSSSPKPEAQEGCVLGRCPKNNRLQWIASAWTECSATCGLGVRKREFKCMEKTLQGKLMTFPERRCRNIKKPNLELEETCNRRACP---VYSMAAG--------WYSSPWQQCTVTCGGGVQTRSVHCMQQGRPSSSCLLHQKPPVLRACNTNFCPVPE----------KRDDPSCVDFFSWCRLVPQHGVCNHKFYGKQCCRSCSRKS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q4VC17-1", "uniprot_id": "ATS18_MOUSE", "id": "Q4VC17-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 18", "aln": "----MECALLCLCALRA----AGPGPPWGPAGLGRLAKALQLCCFCCASVAVALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHH-RKRRSAHGASNSLHYRVSAFGQDLHLELKP-SAILSSHFRVQVLGKDGASETREPE-VPQCLYQGFIRNDSSSSVAVSTCAGLSGLIRTRDNEFLISPLPQLLAQEHN------YSSPAGHHPHVLYKRTAEKR--------------VRWYQDYPGSQRTYPGHSPSHTPPASQSQEPEYSHRRWQKRHFCGRRKKYAPKPPAEDAYLRFDEYGGTGRPRRSAGKSQN--GLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTIGSDINIVVVSLILLEEE--PEGLLINHHADQSLNSFCQWQSALVG---KNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNPCRKAEG---NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYPDKLPGQIYDADMQCKWQFG--AKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTACGLSMWCRQGQCVKLGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCPENSLDFRAQQCAEYNNKPFRGWLYRWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLSQHKAN--EYYPVVTIPAGARSIEIQELQLSSSYLAVRSLSQ--KYYLTGGWSIDWPGDFTFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILTQGK--NPGIAWKYALPKVMNVTQPATKRYHHTWRTVQSDCSVTCGGGYISIKAICLRDQHTQVNSSFCSVRTK---PATEPKICNAFSCPAYWLPGEWSACSKSCAGGQQSRKIRCVQKKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWSPSPWSQCSKTCGRGVRRREVLCKS----PAAETLPESLCSSSPRPEAQEGCVLGRCPKNNRLQWIASAWSECSATCGLGVRKRELKCVEKTLQGKLITFPERRCRNIKKPSLELEEACNQRTCP---VYSMAVAS-------WYSSPWQQCTVTCGGGVQTRSVHCMQQGRPSSSCLLHQKPPVLRACNTNFCPAPE----------KKDDPSCVDFFSWCHLVPQHGVCNHKFYGKQCCRSCTRKS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TE60-1", "uniprot_id": "ATS18_HUMAN", "id": "Q8TE60-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 18", "aln": "----MECALLLACAFPA----AGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDS-SSGASGLNDDYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKP-SAILSSHFIVQVLGKDGASETQKPE-VQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHN------YSSPAGHHPHVLYKRTAEEK--------------IQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQK--GLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQE--PGGLLINHHADQSLNSFCQWQSALIG---KNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEG---NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG--AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKAN--EYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQ--KYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK--NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTK---PVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG----SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG--------WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPE----------KREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FEJ5-1", "uniprot_id": "E7FEJ5_DANRE", "id": "E7FEJ5-1", "name": "", "aln": "MHTNMDCLFLLLWSLQVPLVTCTSFRSLASVSFGNFLKAVQFCCLHS------VASVSFTGDTGGLYQDYDFATPVEVDSYGGYISHDVSRHGRSRRSLSEAGSLVHYHVSAFGKELHLDLQP-SHVLAEGFTVQTLGAEGINTATLDPSIHNCFYQGSIRNHSDSSVALSTCTGLSGLIRYSSEELFITPLPQHLALQHN------YSAPSGHHPHVIYKRSAERR--------------VHADKTDRTSRFKSSNPYEDHHHHHHHHRHHDYQHGKLQRQHFCGRRKQYTPKPPTEDHFVMPDEFEQQIRVKRSEITSSKEGGLNVETLVVADRKMLEKHGRDNVTTYVLTVMNMVSSLFKDGTIGNDINIVVVSLLLLEKD--PLGLSINHHADQSLNSFCQWQSGLVG---KNGKRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKTEG---NIMSPTLAGNNGVFSWSACSRQYLNRFLGTAQASCLVDEPKQIGQYKYPEQLPGQLYDADIQCKWQFG--SKAKLCGLDFVKDICKSLWCHRTGHRCETKFMPAAEGTICGADMWCRKGQCVKFGDHGPKAVHGQWSGWSEWSDCSRTCGGGVMYRERSCNSPSPQHNGKFCQGPGRLHQLCNTKPCQPDGVDFRAQQCAEYNSKPFRGWYYKWKPYTKVEEEDICKLYCIAEDFDFFFAMSSKVKDGTSCSDYKGGVCIDGICEPVGCDQVLGSKAALDACGVCKGDNSTCKFYSGQYTLQHRAN--EYYPVVMVPAGARSIQVQEMEISNSYLAVRSLKRG-TYYLTADWTVDWPGRFQFAGTTFNYQRSFNRPETLFATGPTNETLLFEILLQGK--NPGITWEYTLPHPE-------KKHNYTWSVVRSDCSAPCAGGRVSTKAICLQDQQTQVNSSLCNPQTR---PVVGSHLCNTQPCPAYWTTGKWGVCSRTCGGGQQTRNIRCLRKVTYQREEVAAQSLCPVMAPAQLQPCNTQSCPPEWSTSSWTQCSKTCGRGLKKRSVFCRSTDPGARAVVVPDSMCKLHLKPKAQESCVLSRCPKNERLQWITSAWGECSASCGAGVRRRELHCGEKDSQGGYTEFPARRCRNLQKPEADLEQSCNNGPCPEPLAPQLLQPGGPSVTLGWYSSPWLQCTVSCGGGVQTRSVQCLRQGRPSVGCFPHQRPISSRACNTHFCPAPIPVPVPPPSPTLKEDQPCIDFFSWCHLVPQHGVCNHKFYGQQCCKSCSAKRQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W493-1", "uniprot_id": "Q9W493_DROME", "id": "Q9W493-1", "name": "", "aln": "----MTCSRMWIRSRWLG--------LLLHYWLVVVTQGGGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMT-HQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFHR--DLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICANN---CMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWCKVNG-ECVTHMRPTAPGTLCGRNKWCQNGKCVRREELA--AVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFFDKN--NPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDEQETITIPQPIQHSISLYAIVRGNESNAGIFYEFTLPALN----VTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVG-------------------------------------FVAPPQR-----------------RRSVVCLD----EHDVVVADAECGHLQKPAEMEPCESSLPICRTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * : : : . :. . : :*. . : * * . ::: : :. . . :* .. .: ***:* . * .*: : *: : . : :* ::* :*... :.**:***:** * ** :* :* * : . * :. .: : * : **. ..: : : : : : :. .: * : :::* :::: .: * . : : . . . :****:*** .* * ::. *:**:*****.*:** :**..*::*** :: *:.: * :.::*::.*: **.** * *: ::** ***:* :**: : * ***:* :.***. :**::***.*: *:.**:** ******.** *: * :**:**: .:. ..** ***:*:.:**. . ** * *. .:*:*. :*** *:* **: **. :.::: . . :::*.:***: * .* *:: *:* ** ** . **::*:**: : . .::* *. **:**:***:***** ::* *..* * .* :* * : :::*. .** : .*******.::. .::* *:* *: . : : ***:* : :: ...* ***.*: ..:****:*: **** :.*:. * **** *... *: * . *: * :* :** ** * ::*: * :**: : . :**... :. ** * :**: *:* .:. * : . * :.:: : : :*: *.** ::::** : : **..*.** :.** .: :: :: * ::: *. .: *. .***:* .* * *. :* .**: :*.:.* . .:.:: * :* * * . . : ", "identical_positions": 271, "similar_positions": 316, "identity": "20.91%" }, { "cls_id": "homologset.agr.HGNC:17111", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A2E7-1", "uniprot_id": "D4A2E7_RAT", "id": "D4A2E7-1", "name": "", "aln": "MG--PEMRLTRICCCCCLLYQLGFLSHGTISGMQLTPDLEEWEVVFPALWRRESLNATGLSTGSADPGSGRSAGGGS--RGQPSGSSREVRSVARAPLEEAAGGQSEPWFAARPLQPGAEDEEELESQELPRGSSGDTSLPSGAPAPWQPSPSPQPPSSPPPAQQEEPSTEEVLLRIPALSRDLYLLLRRDGRFLAQRFAVEQWPKPGPDPTRATVDPRPPMPSDASCFYTGTVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPFNDTMAIIGHPHRLYRQKRSSEERVTEKSAAHRHHCGVISDKGRPRSKKLAENRREKRYSYKLPQDYNIETVVVADPAMVSYHGAD--AARRFILTILN-MVFNLFQHKSLGVQVNLRVIKLILLHETPADLYIGHHGEKMLESFCKWQHEEFGRKNDIHLEMSTSWGEDVASVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRK--CIIAEDNGLNLAFTIAHEMGHNMGINHDN-DHPSCADGLHIMSGEWIKGQNLGDVS-------WSRCSKEDLERFLRSKASSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWCRVEGDTECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEWSTWSSCSRSCGSGVSSRERKCPGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQWQAVFDEEKPCALFCSPVGKEQPVLLSEKVLDGTSCGYQGLDVCANGRCQKAGCDGLLGSLAREDHCGVCNGNGKSCKVIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDASKQSINSDWKIEHSGAFSLAGTTVHYIRRGLWEKISAKGPTTTPLHLLVLLFQDQNYGLHYEYTVPSDPLPDNQSSKESGPLFMWTHAGWGDCNATCGGGERKTTVSCTKIMNKNISLVDNKKCKDLTKPEPQIRKCNEQPCQTRWMMTEWTTCSRTCGKGVQSRQVACTRQLENGTLIRAWERDCIGPKPATMQRCEGQDCMTVWEAGVWSECSVKCGKGVRHRTVRCTNPRKKCVLSTRPREVEDCEDYSKCYVWRVGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLRQKS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59509-1", "uniprot_id": "ATS19_MOUSE", "id": "P59509-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 19", "aln": "MG--PEMRLTRICCCCCLLYQLGFLSHGTTSGLQLTPDLEEWEVVFPALWRRESLNATGLSGGSSDPGSGRSSGGGG--RGQASGSSREVRSVARAPQEEATRGQSEPWFGS-PLEPGAEDEEELESQELPRGSSGDTALSSGTPASWQPPLPPQRPSSPPPAQQEEPSAEEVLLRIPALSRDLYLLLRRDGRFLAQRFAVEQWPKPGPDPTRATADPGSSLLPDASCFYTGTVLRHPGSLASFSTCGGGLMGFIQLNEDFLFIEPFNDTMAIIGHPHRLYRQKRSTEEKVTENSAVHRHHCGVISDKGRPRSKKIADNRREKRYSYKLSQEYNIETVVVADPAMVSYHGAD--AARRFILTILN-MVFNLFQHKSLGVQVNLRVLKLILLHETPADLYIGHHGEKMLESFCKWQHEEFGRRNDVHLEMSTSWGEDIAAVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRK--CIIAEDNGLNLAFTIAHEMGHNMGINHDN-DHPSCADGLHIMSGEWIKGQNLGDVS-------WSRCSKEDLERFLRSKASSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEAECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEWSPWSSCSRSCSSGVSSRERKCPGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQWQAVFDEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQGLDICANGRCQKAGCDGLLGSLAREDHCGVCNGNGKSCKVIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSFLALRDASKQSINSDWKIEHSGAFSLAGTTVHYLRRGLWEKISAKGPTTTPLHLLVLLFQDQNYGLHYEYTVPSDPLPDNQSSKEPGPLFMWTHAGWGDCNATCGGGERKTMVSCTKIMSKNISLVDNKKCKDLTKPEPQIRKCNEQPCQTRWMMTEWTTCSRTCGKGVQSRQVACTQQLENGTLIRAWERDCLGPKPATVQRCEGQDCMTVWEAGVWSECSVKCGKGVRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRVGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQKS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TE59-1", "uniprot_id": "ATS19_HUMAN", "id": "Q8TE59-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 19", "aln": "MGKNREMRLTHICCCC-LLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADPGWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEE-LESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGAD--AARRFILTILN-MVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRK--CIIAEDNGLNLAFTIAHEMGHNMGINHDN-DHPSCADGLHIMSGEWIKGQNLGDVS-------WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQKS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B7YZP6-1", "uniprot_id": "B7YZP6_DROME", "id": "B7YZP6-1", "name": "", "aln": "------MSSPLVLFTALLLVSSTICQGLPDLHKQMTPEQLQSVFHVDTHDAVPHYELVQLQHHENNHNRRRRSIGKGPKVNAALPPHHVKKDLSKNAYYSELKHEALASGGNHLFAPEVSAIKSHNVSFSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIVHEQHTSNDVGEVFQDEK--NMAAILMRRHMETGDLIMEGSIGHDLVIKPLPHELSPNPEESHHIIYKREASAAEGQL------SDFAFMEP--DDLLASEKLERLQRRQRRSRRSAPSSPDFEDLND---EDEGALDGEPQVAESR-TRSRRQAPYIIYPEVLVIVDYDGYRLHGGDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIIISRGRDATPYLERNRVGRDAIDSAAALTDMGKYLFRERRLPVYD-IAVAITKLDMCRRTSAYGECNRGTAGFAYVGGACVVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIMSDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDS---ALGRSLPGTLLSLDAQCRRDRGTYACFKDER---VCAQLFC-FDAQTGYCVAYRPAAEGSACGNGYHCLDGRCT---PLPSNIIPDYG---HNYRLVYNKIDNKKDAAEDVESSSEETESQEDETESVEDQDEGTTSS---------------------------EEQEDNKIEQSSAAGGAAAQSTTTARSTTTTTVRTTSTTTTTAKPKSKSFGYLHRSLPERQWMQDNGVLVTTRISSSVSSSSSGSSSGEAAATSTRRPTTTTTTQTPNLFQIYTHELRKQ-------IEYYLHMLQTQQHATKFQPEQQQQQSQQQQSIVEIPLVQKSLTN--------YSVTSSSSSTSNGAKQQPP-----------SNKDENQRQQQQQQQAQQQLQDGLPDEENEATAGIQSNEAIERQKRKFPTTP------------TAATSAAQKSATPATPATSATSAR--------PTPTTAKPITTSSFLDAYFK--KLQALHDAGSASSSTTTTTTTSVSSSVSSATSSKQQHPQQQQQQQVQQIADGSHFLKRTPHRSSLKAYKTSSSSSNNS-----SSQTQQQQQQQQQQYATNYIGDTTNNQPAVLDNSGSASSTTETAKKPKIKTQKLIRRTRVMQTQTQTI------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . : . ** . : . *::*: : . . : : . . . : . * * . . . : :.:: . . .: . . : : . . *. :* . .. : . . .: . : ::: *.*: ::: : : :.: :.* .: . . : ... * ::.. * : .** *:** * : : .*: *::* .. ..... . .*:* .. . . * .* : . *.:*:.* **.* .:*::::: * : :. *. :::.: : : :::.. * .: *.. ::* . . .: :* : . :: :* . : . * : ** * : . ** : .** : .*:. :. ***:** :* **. ** .* .* .* :.*: ** *: :.:.:**...::.** :: :. : .*** : * **: *. *.* :* :*: *:* .:.: . *. :*: *. * * *.** . *.:: ::. * :..:: . .: *.:.: :. ..: . *: : . :*:: : *... . : .. . *: : . :. * . * * * : ** : :: .. . : *:. *. . .: ... :.* : :: ** **: : : . .: :: * : : . : *: : : *::.*.. . .:.:* * .: . ::: .. : :...:. :*: : . *. *: .: * . *.... .:..: : ..* * *.*:: : .. : .: :. ..*.. *. *.. ...* *: . : :. :: .: * ::.* *: : . :. : . :.. **:. : : * ..: *. .* ..* : : .. . .. *: ::* : * * :* ", "identical_positions": 146, "similar_positions": 400, "identity": "11.89%" }, { "cls_id": "homologset.agr.HGNC:17113", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B0BNG5-1", "uniprot_id": "B0BNG5_RAT", "id": "B0BNG5-1", "name": "Hypoxia-inducible factor 1-alpha inhibitor", "aln": "MWKFHLYGVRCGCSGKGGAPTSGGAVPRVEMAATAAEVAASASGEAREEAEAPGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEIKFHEFVEKLQAIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFRNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BLR9-1", "uniprot_id": "HIF1N_MOUSE", "id": "Q8BLR9-1", "name": "Hypoxia-inducible factor 1-alpha inhibitor", "aln": "------------------------------MAATAAEVAASGSGEAREEAEAPGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMGNFQNFKPRSNREEIKFHEFVEKLQAIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFRNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NWT6-1", "uniprot_id": "HIF1N_HUMAN", "id": "Q9NWT6-1", "name": "Hypoxia-inducible factor 1-alpha inhibitor", "aln": "------------------------------MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P59723-1", "uniprot_id": "HIF1N_DANRE", "id": "P59723-1", "name": "Hypoxia-inducible factor 1-alpha inhibitor", "aln": "------------------------------MAETDGAAAFT---ELRD------PDWDESQLRQYTFPTRQIPRLSHTDPRAEVLINNEEPVVLTDTSLVYPALKWDIPYLQENIGNGDFSVYIAENHKFLYYDEKKMVNFQDFVPKSRRIEMKFSEFVDKMHQTEEQGGKGRVYLQQTLNDTVGRKIVVDFLGFNWNWINKQQAKRNWGPLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFDCLYPYPVHHPCDRQSQVDFENPDYDKFPNFKNAVGYEAVVGPGDVLYIPMYWWHHIESLLNGGETITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGDPHEVGPLLNMMIKGRYDHGLS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** * . .. : * *: * *******.*:**** *****::***** **:**********.*********: ************** *..*********** ***:* *:*.* *:** ***:*:: :::**: *:***************:**************.**.** *******************************:***********:*******************:****::****:*.****:************************* ******************************************:*:******* ******: ", "identical_positions": 280, "similar_positions": 40, "identity": "73.11%" }, { "cls_id": "homologset.agr.HGNC:17116", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A342-1", "uniprot_id": "A0A8I6A342_RAT", "id": "A0A8I6A342-1", "name": "Cation channel sperm-associated protein 1", "aln": "MDQPSRTDESYYETHSGSLDPSHHFHPPSSYPYPHPTLYRPSLGGVLHHE--SPQHGVSPQP------------SQQHAGFYQQNESQHLRG--------SDFHDSAFPHHSYHQDRAHFSTSPTNVPH---TYGGPHPLAESQHSGGPQDG----------------------SHIES-YHSHQGNPRKPSVALSHPSSIG------------SHQGKTHHHY-ERPQYLDPRQSRRQSDLSDNLS----HRSGEEYQNQERSGLQVGQQQEGQRASSKRGEHRRRRGDY----LKYKD----RIRHRR-----------PSASQLS--HKSHSTEGTSPSHMRSK-------------SLASMPQSHLGVQS---YVSSQVHSGD-SLKESVSWSD-EDHVQKRKK--AQRTHKKAHSGNVFHLIWEKISQLLLGLRQMLLTLTQSLCFETFIFLVVCLNTIVLVAQTFTELEIRGEWYFMVLDSIFLSIYVIEAFLKLIALGMEYFYDPWNNLDFFIMVMAALDFVLLQINSLSYSFYNHSMFRILKVFKSMRALRAIRVLRRLSILTSLHEVTGTLSGSLPSITAILSLMFTCLFLFSVVLRALFQESDPKRFNNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILVIYIIIQYFIFLNLVIAVLVDNFQMALLKGLEKVKQEQAARVHEKLLDDSLTDLNKADPDAQMTEETLKTQLIERMFGNMTEKQRKLHFQFLQLVAAVELHQQKFRSQAFVIDELVDTAFEAGDDDFGK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZR5-1", "uniprot_id": "CTSR1_MOUSE", "id": "Q91ZR5-1", "name": "Cation channel sperm-associated protein 1", "aln": "MDQSSRRDESYHETHPGSLDPSHQSHP---HPHPHPTLHRPNQGGVYYD---SPQHGMFQQP------------YQQHGGFHQQNELQHLREF-------SDSHDNAFSHHSYQQDRAGVSTLPNNISH---AYGGSHPLAESQHSGGPQSG----------------------PRIDPNHHPHQDDPHRPSEPLSHPSSTG------------SHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQR----HYHGDHMHHHIHHRS-----------PSASQLS--HKSHSTLATSPSHVGSK-------------STASGARYTFGARS---QIFGKAQSRE-SLRESASLSEGEDHVQKRKK--AQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NEC5-1", "uniprot_id": "CTSR1_HUMAN", "id": "Q8NEC5-1", "name": "Cation channel sperm-associated protein 1", "aln": "MDQNSVPEKAQNEADTNNADRFFRSHS--SPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTH--SFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** * ::: *:.... * .: *. *: :* *. :. . *:* :* : * ..::.: :* * : :. . .*:** :* . * *** * ::*:: *.: * .: : .* :* * *..* . .*:* .*:: .: :: : :.. . : * :.. :: : : : ::*:* :: . : * : :* *:**** *.*:* :*. *: * * .: :* : :.:: : * :.* . .. *.:.****. **::**.*: *:*: :***:: *: *:::*: .***** ******:******::******:*:*********.*****:.***:**.**:****:.**:* *********.**.***:*:* : *:::*::*:*********:*************:***::**:***. *****:*** **********.******:.******:*****:*****:**********:*.************:***:***********:****.** **:*****.* *:***::****:****:*. *:.. :* :: :*** **.** **: * *::*****:** .******** ****:** :****::*: :", "identical_positions": 318, "similar_positions": 191, "identity": "40.56%" }, { "cls_id": "homologset.agr.HGNC:17117", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B2RYM9-1", "uniprot_id": "B2RYM9_RAT", "id": "B2RYM9-1", "name": "", "aln": "---------------------------------------------------------------------MGRWALDVAFVWKAALTLGLVLLYYCFSIGITFYNKWLTKS-----FHFPLFMTMLHLAVIFLFSALSRALVQCSSH---RARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFN---------VEGFALVLGASFIGGIRWTLTQMLLQ-----------------------------KADLGLQN-------------PIDTMFHLQPLMFLGLFPLFAVFEG-LHLSTSEKIFRFQDPG----------LLLWVLGSLLLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS-LLNWLGFALCLSGISLHVALKALHSRG-----------------------------------------------------------DGGPKP-----RKGLGSSADLELLLQSSQ--------------------------------QEE-DNGEEEYFMTQGQQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VCX2-1", "uniprot_id": "S35H1_MOUSE", "id": "Q8VCX2-1", "name": "Solute carrier family 35 member H1", "aln": "---------------------------------------------------------------------MGRWALDVAFVWKAALTLGLVLLYYCFSIGITFYNKWLTKS-----FHFPLFMTMLHLAVIFLFSALSRALVQCSSH---KARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFN---------VEGFALVLGASFIGGIRWTLTQILLQ-----------------------------KADLGLQN-------------PIDTMFHLQPLMFLGLFPLFAIFEG-LHLSTSEKIFRFQDTG----------LLLWVLGSLLLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS-LLNWLGFALCLSGISLHVALKALHSRG-----------------------------------------------------------DGGPKP-----LKSLGSSADLELLLRSSQ--------------------------------QEE-EDGEEEYFVTQGQQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NQQ7-1", "uniprot_id": "S35H1_HUMAN", "id": "Q9NQQ7-1", "name": "Solute carrier family 35 member H1", "aln": "---------------------------------------------------------------------MGRWALDVAFLWKAVLTLGLVLLYYCFSIGITFYNKWLTKS-----FHFPLFMTMLHLAVIFLFSALSRALVQCSSH---RARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFN---------VEGFALVLGASFIGGIRWTLTQMLLQ-----------------------------KAELGLQN-------------PIDTMFHLQPLMFLGLFPLFAVFEG-LHLSTSEKIFRFQDTG----------LLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQIS-LLNWLGFALCLSGISLHVALKALHSRG-----------------------------------------------------------DGGPKA-----LKGLGSSPDLELLLRSSQ--------------------------------REEGDNEEEEYFVAQGQQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IIX0-1", "uniprot_id": "A0AC58IIX0_DANRE", "id": "A0AC58IIX0-1", "name": "Collagen alpha-1(XX) chain", "aln": "------------------------------------------------------------------------MACPTHFLCKALRTVGLVLFYYAFSIGITFYNKWLMKD-----FHFPLFMTLVHLTIIFCLSTLTRSAMQCWTG---KPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFN---------LEGFIMVLLASFIGGIRWTLTQLLMQ-----------------------------KAELGLQN-------------PIDTMYHLQPLMFLGLFPLFLLNEG-LSVSTTEKLFRVSELS----------HLLYSLVTLSVGGMLAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAVEFLGDKMS-TVNWLGFAVCLSGISLHIGLKTYRNKGFLIGTNTFTMAHISPLVLPERMTIFLVTVLLILVSEVQTQGRLKLTVLSEDRLQMKWKEAEGPVQGYKVRVRPITEVPQPELMLTTTRGRATVAGLDSRQEYLLQVMAINGTQEKLIAKRRFTIDGLREEELIRSGNREQKKKTPAIGSGSGEVDDVTEALEGLPTVLYREPTTTEPSVVPELEPEADQGTKEKKKKKDKNRSKAEDRIDQEENEGKSAKEEDSDTSKLRKTTPTQPGTAVSTRKPFECSAEAQAELVLLVDGSWSIGRTNFRKVREFLQGLAVPFHIGPEGVQIALSQYSGDPRTEWHLNNFTSKEPLLEAVRNFRYKGGNTFTGQALIHALENNLKEEVGARPNTPQFLLLLTDGKSQDDAIAAANRLKNAGVEIIAIGVKNADEAELRQVASEPLELNVYKVNDFPLLSKLVGKLARILCGKIEDRIKAKRMEHPTQEPVLSFPSPTDLQYVGLGSRELRLRWTVPSRNPQQYRVVYHTAEGQSLNELVVNGTESTTLLTGLSSQTQYHLSIFPVYENKVGSALRGTFTTLPLAIPEALEVTASSASSLRVRWQPAAGATQYMALYSALNDGEPDDAKEVKFGPAQTDVELVDLIPSTDYSVTLYALYDEDPSDPITAIGTTFPLPSPLSLQFPMVSHSTLMVTWVPGAVDVPAHRIIYSTNHGSDVKQVEVRGVNTVLLQNLSSLSRYLVSVHSLYEKGLSSPVTANVTTLRVPAPSDLRVTNFTGSEITVRWEAAADDVVFYLIKWISLNGGDLSQLMINGKGEGAILEKVEEDKEYQISLSASYADGAQSEAVAIRYSTLSGGGPSSLSISEETAVSMLVTWVHPNAHVQQYRVSFTPLNGDARENTVSLAGSERRILLQNLLPDTRYSVLVTAEYRSREGGSASAQGKTTSLRVSSVSVVRSDHSSICVSWRPVPAVSGYRIVIQALREKQTKEEMVDASSSSHCFSELQPETVYRISVHSRLGAVEGAAVTILHPTATAPVRVQVPPGLHPIQREVCPEMTVRNYVLKGFDMMEAFGLTQRAHSTIEGVAAEPFIFSTLPSYTLYRDVQLTQSTGFIHPAGFSPEHTISMVFRLLQDSPREPFALWQLTDNDFQPKMGVVLDPEKKVLLYFSLDYKGEIQELTFDQPQVHSIFYGSFHKIHLSVSQVSVSLSVDCQRVGERPARPLGTLPTDGFEMLGKLVKTRGPHSGSAAFQLQSFEIVCNTTWASEDSCCDLPSQRDEESCPAPAYACTCTTDVPGSPGDTGPSGKPGVRGEKGEKGEVGQKGEVGPPGKSGPEGGFGALGPAGPRGIAVMGKMGPPGARGEKGDIGRPGSQGLPGPPGQKGGEGNPGPKGTRGVEGNIGPPGITGPRGLQGMPGHPGPVGDRGPLGPVGPTGLPGSKGERGEKGEPQSLAMIYQLVSQACEKLVHNEVLKMDAFLNELNRKPVPIQEPVAPPGEPGIPGGRGAPGPRGPQGRLGSRGMPGKPGYPGEQGRRGMAGEKGSPGANAVGPQGMKGFGGPPGEAKIGEPGPKGEDGKAGPTGIPGAAGQQGEMGPSGVCDSSGCYQGPPAEDPYLGYRP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VZP2-1", "uniprot_id": "Q9VZP2_DROME", "id": "Q9VZP2-1", "name": "Sugar phosphate transporter domain-containing protein", "aln": "MVAAKYERLNTSGEAAGNGNGNASDAEDEEIELHLAQKTQLGNGHRLRQSNFKYASGKCGSGEAPCTNETATLAQENMMMQMAVGTLAIIFLYLALSISLTFYQTDINRQ-----MPFPLAIVTYHLVVKFLLAAAARRIYRMRVG---RSRVQLDWRLALRKMAPTGVASAIDIGFSNWGLALVPISLYTMTKSSTIVFILLFAIAFGLEKKSWYLVSIVGLIGTGLLMFTYKSTDFN---------ALGFFFILFASLSSGLRWSFAQFIMQ-----------------------------KSKLGLHN-------------PIDMIYYMQPWMIASLVPLVIGIEG-AGLIAVIEDLHNHTSN----------EITWAIARISAGALLAFLMEFSEFLVLCKTSSLTLSIAGIFKDICQLALAVTIRKDHLS-VINYIGLIICLAGIVCHLLHKYSNMKE---------------------------------------------------------------------------MQRQQELQLDNDQ-----------------------------------EESSPGEYKFNDGSAIVGVHVKS---------------HSTLTVPLLEQTDSEDESGASNKQNASDVIFDVLKRRDMQR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03697-1", "uniprot_id": "YMD8_YEAST", "id": "Q03697-1", "name": "Putative nucleotide-sugar transporter YMD8", "aln": "--------------------------------------------------------------------------------MNRTVFLAFVFGWYFCSIALSIYNRWMFDPKDGLGIGYPVLVTTFHQATLWLLSGIYIKLRHKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSFQYVPLTIYTIIKSSSIAFVLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTSTKNDQALVIFGSFLVLASSCLSGLRWVYTQLMLRNNPIQTNTAAAVEESDGALFTENEDNVDNEPVVNLANNKMLENFGESKPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFSSSIFRLDTSNGGVGTETTVLSIVRGIVLLILPGFAVFLLTICEFSILEQTPVLTVSIVGIVKELLTVIFGIIILSERLSGFYNWLGMLIIMADVCYYNYFRYKQDLL----------------------------------------------------------------------------QKYHSVSTQDNR-----------------------------------NELKGFQDFEQLGSKKIAP--------------------YSISVDLTNQEYELDMIAQNVSRSSQQV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.::: : **.:::*: : : :*: :. * . : :: : : . : * * : **.:*:: *:*:** .: :.:::**: ***:: *:*:*. * **: * * :: *: ::. *.:: . * ::* :* .*:** :*:::: :. :.* * **. :. : * * *. * . :: . : : : .: .* : :.** :: :*. **:**.**.*:: : :. : :::* *::*: : ::.: : : . .: : : : *. ", "identical_positions": 59, "similar_positions": 121, "identity": "2.89%" }, { "cls_id": "homologset.agr.HGNC:17118", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7ENQ2-1", "uniprot_id": "F7ENQ2_RAT", "id": "F7ENQ2-1", "name": "RING finger protein 32", "aln": "MLKNKDRSSKKSNLAVSAVALQDHILRDLQLGHLSVADPCKTKVQKKENKSQSLRKGSAAMMDTGLRKTAEGPKGEDPEKEYVLDPTPPPLTLAQKLGLLALPPLPLSSDEWEKVKQRSLLQGDSMQPCPICKEEFELQPQVLLSCSHVFHRACLQAFEKFTNRKTCPLCRKNQYQTRVIHDGARLFRVKCATRIQAYWRGYIVRKWYRNLRKMIPPTDAKLRRKFFEEKFTEISHRILCSYNTNIDELFSEIDVCLAVNRSILQQLDERCGQEITEEDWEKIQAQAAHHEIYECSICLTPLFFHCDGRQAAAGTSSQHPRETVLLSCAHLFHNACLLALEEFSLGDNAPFNVCPLCRSCYQKKIVEY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JIT1-1", "uniprot_id": "RNF32_MOUSE", "id": "Q9JIT1-1", "name": "RING finger protein 32", "aln": "MLRNKDRSSNKGNLAVTAVALQDHLLHDLQLGHLSVADPCKIKARKKEKKSKSLKRDATAIIDTGLRKSTEGPNMEDPEKEYVLDPTPPPLTLAQKLGLLPPPPLPLSSDEWERVKQRSLLQGDSIQPCPICKEEFELHPQVLLSCSHVFHRACLQAFEKFTNKKTCPLCRKNQYQTRVIHDGARLFRVKCATRIQAYWRGYIVRKWYRNLRKIIPPSDAKLRRKFFEEKFTEISHRILCSYNTNIDELFSEIDVCLAVNRSILQQLDERCGQIITKEDWEKIQAQAAHHEIYECSICLTPLSFHGDGRQAAIGTSSQRPRETVLLSCAHLFHNACLLALEEFSLGDNAPFHVCPLCRSCYQKKIVEC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H0A6-1", "uniprot_id": "RNF32_HUMAN", "id": "Q9H0A6-1", "name": "RING finger protein 32", "aln": "MLKNKGHSSKKDNLAVNAVALQDHILHDLQLRNLSVADHSKTQVQKKENKS--LKRDTKAIIDTGLKKTTQCPKLEDSEKEYVLDPKPPPLTLAQKLGLIGPPPPPLSSDEWEKVKQRSLLQGDSVQPCPICKEEFELRPQVLLSCSHVFHKACLQAFEKFTNKKTCPLCRKNQYQTRVIHDGARLFRIKCVTRIQAYWRGCVVRKWYRNLRKTVPPTDAKLRKKFFEKKFTEISHRILCSYNTNIEELFAEIDQCLAINRSVLQQLEEKCGHEITEEEWEKIQVQALRRETHECSICLAPLSAAG-GQRVGAGRRS---REMALLSCSHVFHHACLLALEEFSVGDRPPFHACPLCRSCYQKKILEC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:**.:**:*.****.*******:*:**** :***** .* :.:***:** *::.: *::****:*::: *: **.********.************: ** ********:***********:************:************:***********:************************:**.********* :********** :**:*****:****:*****************:***:*** ***:***:****:*:**: **:*:*****.** ::* :******:** *::.. * * ** .****:*:**:**********:**..**:.************:* ", "identical_positions": 270, "similar_positions": 68, "identity": "73.37%" }, { "cls_id": "homologset.agr.HGNC:1712", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P56389-1", "uniprot_id": "CDD_MOUSE", "id": "P56389-1", "name": "Cytidine deaminase", "aln": "----------------------------------------------------------------------------------------------------MAQERPSCAVE--------PEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDG-RIFSGCNIENACYPLGVCAERTAIQKAISEGYKD-FRAIAISSDLQEEFISPCGACRQVMREFGT--DWAVYMTKP--------------DGTFVVRTVQELLPASFGPEDLQKIQ--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4AC20-1", "uniprot_id": "D4AC20_RAT", "id": "D4AC20-1", "name": "Cytidine deaminase", "aln": "----------------------------------------------------------------------------------------------------MAQERPSCAVE--------PEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDG-RIFSGCNVENACYPLGVCAERTAIQKAISEGYKD-FRAIAIASDLQEEFISPCGACRQVMREFGT--NWAVYMTKP--------------DGTFVVRTVQELLPASFGPEDLQKIH--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P32320-1", "uniprot_id": "CDD_HUMAN", "id": "P32320-1", "name": "Cytidine deaminase", "aln": "----------------------------------------------------------------------------------------------------MAQKRPACTLK--------PECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEG-RIFKGCNIENACYPLGICAERTAIQKAVSEGYKD-FRAIAIASDMQDDFISPCGACRQVMREFGT--NWPVYMTKP--------------DGTYIVMTVQELLPSSFGPEDLQKTQ--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1P5S0-1", "uniprot_id": "A0A8M1P5S0_DANRE", "id": "A0A8M1P5S0-1", "name": "Cytidine deaminase", "aln": "----------------------------------------------------------------------------------------------------MSSCNP-----------------QVLVQRSQEARKLAYCPYSRFRVGAAVLTSDG-TVFTGCNVENACYTAGLCAERTAISKAVSEGHTT-FKAIAIASDLEDRFISPCGACRQFMREFGS--QWDVYLSKT--------------DGSFKQMTVEELLPCSFGPDDLRARENP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLR2-1", "uniprot_id": "Q9VLR2_DROME", "id": "Q9VLR2-1", "name": "Cytidine deaminase", "aln": "------------------------------------------------------------------------MTHLT-----------------------KNFARPEKNEE-VVTFGSLDPSVQELLTAAFQVRQRAYVPYSGFKVGAAFRAKVDGKIFTGCNVENAAFTPGSCAERTAIAKAVSEGATE-FLAGAVLAYEPNVFTTPCGVCRQFIREFAN-ADIPIYVAQAIDARIAEKQELLQSDDPVMCTSIFNLLPSSFHTYRK------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q7KTJ2-1", "uniprot_id": "Q7KTJ2_DROME", "id": "Q7KTJ2-1", "name": "cytidine deaminase", "aln": "MSEKRKLLQRYMRNLSDLQDELKRKELEKKMKELEMLQAKLARRQEQSGTKCAGGKIKNLRQKNLRKVLGKYMMTLEGFLCELARREARLNGDRGRASESENLPHPQMLEEYTVAFCAVGEDGRELLEAALSARRCAYAPYSKFKVGAAFRAKCG-RIYAGCNIENVAFTPGNCAERCALAKGISEGEKK-YTAGAVVAYHPDGFTTPCGVCRQFILEFIQ-NDIPIYIAKAPPPEQENCIPSIPDEAEVLVTSAYHLLPHSFNSFE-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VLR3-1", "uniprot_id": "Q9VLR3_DROME", "id": "Q9VLR3-1", "name": "Cytidine deaminase", "aln": "------------------------------------------------------------------------MTQVF-----------------------INGARDDLNVR---EFQSLDPSIQEIILAATEARKQAYCPYSNFAVGAALRTSDG-TIYSGCNIENGAYATCICAERTAAVKAISEGKRD-FVACAVVAQQDNGFTTPCGVCRQFLSEFVNGKDIPLYAAKPTNLPLR-----------VLCTSVLQLLPNGFSFANGK-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06549-1", "uniprot_id": "CDD_YEAST", "id": "Q06549-1", "name": "Cytidine deaminase", "aln": "----------------------------------------------------------------------------------------------------MKVGGIE------------DRQLEALKRAALKACELSYSPYSHFRVGCSILTNND-VIFTGANVENASYSNCICAERSAMIQVLMAGHRSGWKCMVICGDSEDQCVSPCGVCRQFINEFVV-KDFPIVMLNST-------------GSRSKVMTMGELLPMAFGPSHLN-----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : .. . :* *** * **.:. : . :: *.*:** .:. **** * : : * : . .: . : :***.***.: ** : : :. : .*** .* ", "identical_positions": 29, "similar_positions": 38, "identity": "10.58%" }, { "cls_id": "homologset.agr.HGNC:17123", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BLV3-1", "uniprot_id": "SL9A7_MOUSE", "id": "Q8BLV3-1", "name": "Sodium/hydrogen exchanger 7", "aln": "MEPSDAARPGPGRAFRGLSPRLLLLPLLPVLLGRGLRAGAAASS---GAAAEDSSAMEELATEKEAEES----HRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYG-TPATSGHDKS----LSCTQEDRAFSTLLVNVSGKFFEYTLKGE-------ISPGKINNVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHK------------------IGWNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWVIGGGTTPMLSWLNIRVGVEELSEEDQNENRWQYFRVGVDPDQDPPPNNDSFQVLQGDGMD----------------------------SVGGSRTKQESAWIFRLWYIFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREDDSDFILTEGDLTLTYGDSTVTANGSSSS----YTASTSLECGRRTKSSSEEVLERDLGMGDQKVSSRGTPLVFPLQENA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LXD6-1", "uniprot_id": "A0ABK0LXD6_RAT", "id": "A0ABK0LXD6-1", "name": "Sodium/hydrogen exchanger", "aln": "MEPSDAARPGPGRAVPGLSPRLLLLPLLPMLLGRGLRAGAAASSS--GAAAEDSSAMEELATEKEAEES----HRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYG-TPATSGRDKS----LSCTQEDRAFSTLLVNVSGKFFEYTLKGE-------ISPGKINNVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTADVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHK------------------IGWNFQHMMMFSGLRGAMAFALAIRDTASYSRQMMFTTTLLIVFFTVWVIGGGTTPMLSWLNIRVGVEELSEEDQNEHRWQYFRVGVDPDQDPPPNNDSFQVLQGDGLD----------------------------SVGGSRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLMARCLTSPQVYDNQEPLREDDSDFILTEGDLTLTYGDSTVTANGSSSS----YTASTSLECGRRTKSSSEEVLERDLGMGDQKVSSRGTPLVFPLQENA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96T83-1", "uniprot_id": "SL9A7_HUMAN", "id": "Q96T83-1", "name": "Sodium/hydrogen exchanger 7", "aln": "MEPGDAARPGSGRATGAPPPRLLLLPLL---LGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEES----HRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYG-TPATSGRDKS----LSCTQEDRAFSTLLVNVSGKFFEYTLKGE-------ISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVN-ANVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHK------------------IGWNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPD----------------------------SARGNRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSS----HTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVFPLEDNA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BDB4-1", "uniprot_id": "A0A8M2BDB4_DANRE", "id": "A0A8M2BDB4-1", "name": "Sodium/hydrogen exchanger", "aln": "MEAAKAPKP----WTLYLPNPSSLFPLFVFILSQCYRISA------------DDGGIEELATEKEAEES----HRQDSVNLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLLVGVILRYG-IPSTSYHNKTP---PSCMLKEGPVSTVLLNVSGKFFEYTLKGE-------INLREIHSVEQNDMLRKLTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSIITYAFLGTAISCFVIGNLMYGVVKLMQVLGQLTDKFYYTDCLFFGAIISATDPVTVLAIFNELHADGDLYALLFGESVMNDAVSIVLSSSIVAYQPSGANTHTFDASAFFKSVGVFIGIFSGSFAMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSEESTKRTKQLFEVLHFLAENFIFSYMGLALFTFQNHVFSPIFIVGAFLAIFIGRALNIYPLSFLINLGRRHK------------------IRGNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFTTTLLIVFFTVWVFGGGTTPMLSWLHIRVGVD--------------------PDQDLQPCGDSFQVLQGDGSQ----------------------------SEGQSKTKQESAWLFRLWYTFDHNYLKPILTHSGPPLTSTLPACCGPLARCLTSPQAYETHEPLRDNDSDLILNEGDLTLTYGDTAITANGASSSSGPEGSAGIWGLNGKRSDSTSEDALERELDTREHELLSRGTRLVFPIEDHA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IPJ4-1", "uniprot_id": "Q8IPJ4_DROME", "id": "Q8IPJ4-1", "name": "Sodium/hydrogen exchanger", "aln": "--------------------MLLIVGFALCVLAPGC-----------------SATDTDIALDAKATLN----HRIQSLDLLVFVFLLALTVLTIWLFKHHRVSWLHETGLAVIYGLIVGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQVHDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLMPKY--LSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRVRDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFIFSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPK------------------ISTNFQHMLFFAGLRGAMSFALAIRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIPVGVDDETEQLNNYQVHSVYN--SMDNSHPQTSDGYLQDVEGGGVNRNKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYMKPLLTHSRPTLLETLPVCCNPIARLLTT------TQQLTQDGSEFRRVDSDSDICIDN--DTGNGLSQD-----GSGAAPGVGRR-NSLSRSVHLNEANHLANELSLVANNFM-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04121-1", "uniprot_id": "NHX1_YEAST", "id": "Q04121-1", "name": "Endosomal/prevacuolar sodium/hydrogen exchanger", "aln": "-----------------MLSKVLLNIAFKVLLTTAKRAVDPDDDDELLPSPDLPGSDDPIAGDPDVDLNPVTEEMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMVIGLIIRMS------------------------------------------------------------PGHYIQDTVTFNSSYFFNVLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGIILY----IWTFLGLESIDISFADAMSVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHG-----QPATFSSVFEGAGLFLMTFSVSLLIGVLIGILVALLLKHTHIRRYPQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARLSENFIFIYLGLELFTEVELVYKPLLIIVAAISICVARWCAVFPLSQFVNWIYRVKTIRSMSGITGENISVPDEIPYNYQMMTFWAGLRGAVGVALALGIQGEY-KFTLLATVLVVVVLTVIIFGGTTAGMLEVLNIKTGCISEED--------------TSDDEFDIEAPRAINLLNGSSIQT---------------------------DLGPYSDNNSPDISIDQFAVSSNKNLPNNISTTGG---NTFGGLNETENTSPNPARSSMDKRNLRDKLGTIFNSDSQWFQNFDEQVLKPVFLDNVS----------------PSLQDSATQSPADFSSQNH---------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . :* : .. . . .* *: :::** :: : : :.::*: :*** *:::**:::* *:* . : : . **:.. ***::*****: :**.*:: **.*: :*: :*: ** :*..:** ::* : : .: : *.: .** :*.***:*:*:*** :.* .**::::***::***::**: : : ::.:.. . *: * *: :*. * * : *.*::: :* :*:.*:.*:::.::::::. ::*:*::***** **:* *:* * * :*::* *:***** *:*: :** : :.. :*: * :. :.* ::*** ::* : * * *:* * :::*****:..***: : ::::. ::*.:** : ** : :*. *:* .* :. :: ::*.. : . .:. : . : : :: : *: .. . * :. . : :.: .: . .. * . .. . :: ", "identical_positions": 134, "similar_positions": 211, "identity": "16.86%" }, { "cls_id": "homologset.agr.HGNC:17125", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZWX2-1", "uniprot_id": "D3ZWX2_RAT", "id": "D3ZWX2-1", "name": "", "aln": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSH-FWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFR-------KKARVVITQSPGKYVLPP--PKLNIEMPD", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AF53-1", "uniprot_id": "T185A_MOUSE", "id": "A2AF53-1", "name": "Transmembrane protein 185A", "aln": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSH-FWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFR-------KKARVVITQSPGKYVLPP--PKLNIEMPD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NFB2-1", "uniprot_id": "T185A_HUMAN", "id": "Q8NFB2-1", "name": "Transmembrane protein 185A", "aln": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSH-FWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDNEETEETPVPEPPKIAPMFR-------KKARVVITQSPGKYVLPP--PKLNIEMPD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7SYC7-1", "uniprot_id": "T185L_DANRE", "id": "Q7SYC7-1", "name": "Transmembrane protein 185-like", "aln": "MNLRGVFQDFNPSKFLIYACLLLFSVLLSLRLDGIIQWSYWAVFAPIWLWKLMVIIGASVGTGVWAHNPQYRAEGETCVEFKAMLIAVGIHLLLLTFEVLVCERVERASIPYWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALKLDGIISWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMAISWMTIVVPLLTFEILLVHKLDNHYSPNYVPVFVPLWVSLVTLMVTTFGQKGGNHWWFGIRKDFCQFLLELFPFLREYGNISYDLHHEDSDMSEELPIHEVPKIPTMFR-------KKTGVVITQSPGKYFVPP--PKLCIDMPD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VWK7-1", "uniprot_id": "Q9VWK7_DROME", "id": "Q9VWK7-1", "name": "Transmembrane protein 185B", "aln": "MNLESLFRDFNPCKFIVHCSLFIFVTLFALRLDNYIDWPYWAIFTPLWIWKCTAILGAIVGAIVWCRYPHYRLEGDAYTQFKAMLISLALHLILLMFELLACDKLTSDRH-LWVLVFIPLIFGSVVSVGACVWAVKHDRSFELELFLAVNALQFVSLPLKLDRFVYWNWDVVFVPMWIVICLSLVSVLYNIIFCGIMMRTPEVSLQQKKAALNAAVGNICTVLPLLCFQVVICDKLDGELKFPYIVVFSPLLVSILALIVLSSSAKGGNMWWFGIRKSFSQFLLSAMPFLQEYGNISYHPET-HSNAAQSMPLDAASSSTSMAASEQLHEFHKHDKKSKKGAKNDILKPVVPFVSIDLPD", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***..:*:****.**:::..*::* .*::****. *:*.***:*:*:*:** .*:** **: **.: *:** **:: .:******::.:**:** **:*.*::: *:***:**:* * ***.****..:****:***:: :** ***: :.*:** :: * * ** **:**::.: : *** *::. :::*: :* :*::: :. *:. : *:*** *:::: .***.. : :* ** :*:::*:. : . **** *******.*.****. :***:*******. . ..: ::. *: .. ..* :* .:.. : .: * * : *::**", "identical_positions": 146, "similar_positions": 129, "identity": "40.56%" }, { "cls_id": "homologset.agr.HGNC:17127", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3X943-1", "uniprot_id": "S39A2_MOUSE", "id": "G3X943-1", "name": "Zinc transporter ZIP2", "aln": "------------------------------------------------MEVLLGVKIGCLLALLVLTLGCGLTP----IYVKWFQMDAATGHHHRVLSLLGCTSAGVFLGAGLMHMTAEALEGIESEIQKFVEQNSTGSKGNSSRDAASSYVEYPYGELVISLGFFFVFLLESLALQCCH---GAAGGSTVQ----EEEWGGTH-------AFGFHKHPAVPSPS--------------------------------------------------------------RGPLRALVLLLSLSFHSVFEGLAVGLQATVA--ATIQLCVAVLAHKGLVVFSVGLRLGKIGT---GPRWATFCILSLALMSPVGLALGLTVAG--GASGQTQGLAQAVLEGIAAGTFLYVTFLEILPRELAC-------PEAPLAKYSCVAAGFAFMALIALWA---------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZIN1-1", "uniprot_id": "D3ZIN1_RAT", "id": "D3ZIN1-1", "name": "", "aln": "------------------------------------------------MEVLPGVKIGCVLALLVFTLGCGLTP----IYVKWFQTDAATGHHHRVLSLLGCTSAGVFLGAGLMHMTAEALEGIESEIQKFVVQNSTGSKGNSSRDAAASYVEYPYGELVISLGFFFVFLLESLALQCCH---GAAGGSTVQ----EEEWGGTH-------AFGFHKHPPIPSPS--------------------------------------------------------------RGPLRALILLLSLSFHSVFEGLAVGLQATVA--ATVQLCVAVLAHKGLVVFSVGLRLVKIGT---GPRWATFCILSLALMSPVGLALGLTVAG--GASGQAQELAQAILEGIAAGTFLYVTFLEILPRELAC-------PEAPLAKYGCVAAGFAFMALIALWA---------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NP94-1", "uniprot_id": "S39A2_HUMAN", "id": "Q9NP94-1", "name": "Zinc transporter ZIP2", "aln": "------------------------------------------------MEQLLGIKLGCLFALLALTLGCGLTP----ICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCP---GAAGGSTVQ----DEEWGGAH-------IFELHSHGHLPSPS--------------------------------------------------------------KGPLRALVLLLSLSFHSVFEGLAVGLQPTVA--ATVQLCLAVLAHKGLVVFGVGMRLVHLGT---SSRWAVFSILLLALMSPLGLAVGLAVTG--GDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELAS-------PEAPLAKWSCVAAGFAFMAFIALWA---------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P59889-1", "uniprot_id": "S39A1_DANRE", "id": "P59889-1", "name": "Zinc transporter ZIP1", "aln": "------------------------------------------------MDYLLQVKVGALVGLLLLTLFFGFIP----ARMKWFHVTGGTELHKAVLSFVSCFAGGVFLSACLLDIIPDYLSDIHGELQK--------------RDLDDG---FPLPEFIMACGFFTVLILEKMVLSCTE---GHRNEETAPLLAPAAPNGHAHGHPSVNDLEGSGHHVHVDFHA--------------------------------------------------------------HSSFRSFMLFLSLSLHSVFEGLAIGLQTTNA--KVLEICIAILVHKSIIVFSLSVKLVQSAV---KPLWVVLYVTVFAIMSPLGIGIGIVVIE--TER-QAGGLIQAVLEGLAAGTFIYITFLEILPHELNS-------SERPLLKVLFLLCGFSIMAALCFLG---------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VEX1-1", "uniprot_id": "Q9VEX1_DROME", "id": "Q9VEX1-1", "name": "", "aln": "MNQTQVNNFLKCFLQIDEPSNRWTSRHDGEDLDDNDHDHDHDDDNDDDESGVLVAKVTAMVVLFCASAICGSIPFLLNRCYRWTEN-QTNARSAIVVKCLLYFGGGVLLATTFLHLLPEVQEVVEELQECG----------------IIGELTFPLAELLMCCGFFLMYFIEEAMHTYVH---HHQKD---EAGAAFERGHSIRNSHLLKPTEGNATTPTAPPAPLAGTAELGTLSVQNLLQNDLEQQKFATKPQQQANGHGHSHGHGHGHSHLPVIADDADAGDMLASSLRGLFIVSALSLHELFEGMAIGLESSAS--SVWFMFGAVSAHKLVLAFCVGVELIVART---RMLLAVLYVLTFAVVSPLGIGIGILINH--GEETSGPSLVSAILQGFACGTLIYVVFFEILSKNRSG-------LRAYLALFVGFLVMFGLQQLTSIGGHGHSHSHSSCSTSEHTHNHQETETETRSASGHTHGHQHDHDHPHHHNHAEELATVHNYEQQLQLLRQVTQKLLEAHPKKDA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A1Z6P0-1", "uniprot_id": "A1Z6P0_DROME", "id": "A1Z6P0-1", "name": "", "aln": "--------------MVDQH--------------------------------LIVAKIVAIVVLFLVTLIFCFIPYLLDRFYKWTQRPENNAREFKVVLCLLNFGGGVLIATTFIHMLPEVVEVVNALQDCR----------------MLAPTPFGLPEVLLCTGFYLMYCIEETMHFVVR---RRQQRKLREVVTIKDAGEELRTEIVVQPEE----SPKEP------------------------------------------------------------------NWLRGLGIIVALSLHELFGGMAIGLEMSVS--TVWFMTGAISVHKLVLAFCIGMEIMMAHT---RWLLAVVYLLVFSIVTPIGVGIGIAVSE--SAAANQPSTVSGILQGLACGTLIYVVFFEIVAKNHAG-------IRILLSSMVGFVLMFGLQ--IAIG-EAKGKSHFTCP----------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32804-1", "uniprot_id": "ZRT1_YEAST", "id": "P32804-1", "name": "High-affinity zinc transporter ZRT1", "aln": "------MSNVTTPWWKQWDPSEVTLADKTPDDVWKTCVLQGVYFGGNEYNGNLGARISSVFVILFVSTFFTMFP-------LISTKVKRLRIPLYVYLFAKYFGSGVIVATAFIHLMDPAYGAIGGTTCVG---------------QTGNWGLYSWCPAIMLTSLTFTFLTDLFSSVWVERKYGLSHDHTHDEIKDTVVRNTAAVSSENDNENGTANGSHDTKNG-----------------------------------------------VEYYEDSDATSMDVVQSFQAQFYAFLILEFGVIFHSVMIGLNLGSVGDEFSSLYPVLVFHQSFEGLGIGARLSAIEFPRSKRWWPWALCVAYGLTTPICVAIGLGVRTRYVSGSYTALVISGVLDAISAGILLYTGLVELLARDFIFNPQRTKDLRELSFNVICTLFGAGIMALIGKWA---------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: .:. :: : * * ..**::.: ::.: : : :: .: : . : . *.: :* .: :**: : .: *: . : :. .: .: :*: :.:*: : ..:*:..:.* ::* :.*::.:: . .: ", "identical_positions": 15, "similar_positions": 74, "identity": "2.82%" }, { "cls_id": "homologset.agr.HGNC:17128", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U1X7-1", "uniprot_id": "S39A3_RAT", "id": "Q5U1X7-1", "name": "Zinc transporter ZIP3", "aln": "------------------------------------------------MSQLLVAKVLCMVGVFFFMLLG----SLLPVKVIEADFEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHI----------STDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGGRNHGLYPEPTAHSHGTGLRLRELGR---------------------------------------------PGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAVHETLVAVALGISMARSAVP---LRDAAKLAVTVSAMIPVGIGLGLGIES--ARSVAS-SVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLG-YAVLAGMVFLKW------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99K24-1", "uniprot_id": "S39A3_MOUSE", "id": "Q99K24-1", "name": "Zinc transporter ZIP3", "aln": "------------------------------------------------MTKLLVAKVLCMVGVFFFMLLG----SLLPVKVIEADLEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHI----------STDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGNRSHSLYPEPTAHTHGAGLRLRELGR---------------------------------------------PGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAIHETLVAVALGISMARSAVP---LRDAAKLAVTVSAMIPVGIGLGLGIES--ARSVAS-SVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLG-YAVLAGMVFLKW------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BRY0-1", "uniprot_id": "S39A3_HUMAN", "id": "Q9BRY0-1", "name": "Zinc transporter ZIP3", "aln": "------------------------------------------------MVKLLVAKILCMVGVFFFMLLG----SLLPVKIIETDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLQKVLSLGHI----------STDYPLAETILLLGFFMTVFLEQLILTFRKEKPSFIDLETFNAGSDVGSDSEYESPFMG-GARGHALYVEP--HGHGPSLSVQGLSR---------------------------------------------ASPVRLLSLAFALSAHSVFEGLALGLQEEGEKVVSLFVGVAVHETLVAVALGISMARSAMP---LRDAAKLAVTVSAMIPLGIGLGLGIES--AQGVPG-SVASVLLQGLAGGTFLFITFLEILAKELEEKSDRLLKVLFLVLG-YTVLAGMVFLKW------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VEX1-1", "uniprot_id": "Q9VEX1_DROME", "id": "Q9VEX1-1", "name": "", "aln": "MNQTQVNNFLKCFLQIDEPSNRWTSRHDGEDLDDNDHDHDHDDDNDDDESGVLVAKVTAMVVLFCASAICGSIPFLLNRCYRWTENQTNARSAIVVKCLLYFGGGVLLATTFLHLLPEVQEVVEELQECGIIG---------ELTFPLAELLMCCGFFLMYFIEEAMHTYVHHHQKDEAGAAFERGHSIRN-SHLLKPTEGNATTPTAPPAPLAGTAELGTLSVQNLLQNDLEQQKFATKPQQQANGHGHSHGHGHGHSHLPVIADDADAGDMLASSLRGLFIVSALSLHELFEGMAIGLESSASSVWFMFGAVSAHKLVLAFCVGVELIVARTR---MLLAVLYVLTFAVVSPLGIGIGILINH--GEETSGPSLVSAILQGFACGTLIYVVFFEILSKNR----SGLRAYLALFVG-FLVMFGLQQLTSIGGHGHSHSHSSCSTSEHTHNHQETETETRSASGHTHGHQHDHDHPHHHNHAEELATVHNYEQQLQLLRQVTQKLLEAHPKKDA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0AC58HHL9-1", "uniprot_id": "A0AC58HHL9_DANRE", "id": "A0AC58HHL9-1", "name": "", "aln": "----------------------------------------MTIMMMMDSSAALHLNLLTLTVMFCFSLLCGFSPGFFMRQAARYTSDPGSRLR-ALSLASCLSSGVFLGFSLLDLLPKYLTDMRDTFSRLDI----------TLRFPLSEFLLAMGVLLVLLVEQMLLAFR----EQVCVSSVEKQTLIERTRLYVEDSRT-------------------------------------------------------------------------HEALRVCLLLLCVCVRSLLEGVCAVPPP-----LWSCGAALLREGLLAFGLALQLAPAGLR---RAVATGGLVLFCSARPVAMGTAMLRGTP-GDQAYTADVVRCAVEGLTCGIFICISISGLLFPESSSPKQRMHKVAFLLTG-FALVTAVLISQV------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P32804-1", "uniprot_id": "ZRT1_YEAST", "id": "P32804-1", "name": "High-affinity zinc transporter ZRT1", "aln": "-----MSNVTTPWWKQWDPSEVTLADKTPDDVWKTCVLQG-VYFGGNEYNGNLGARISSVFVILFVSTFFT------MFPLISTKVKRLRIPLYVYLFAKYFGSGVIVATAFIHLMDPAYGAIGGTTCVGQTGNWGLYSWCPAIMLTSLTFTFLTDLFSSVWVERKYGLSHDHTHDEIKDTVVRNTAAVSSENDNENGTAN-GSHDTKNGVEYYEDSDATSMDVVQSFQ---------------------------------------------AQFYAFLILEFGVIFHSVMIGLNLGSVG--DEFSSLYPVLVFHQSFEGLGIGARLSAIEFPRSKRWWPWALCVAYGLTTPICVAIGLGVRTRYVSGSYTALVISGVLDAISAGILLYTGLVELLARDFIFNPQRTKDLRELSFNVICTLFGAGIMALIGKWA-------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * .: : :: : . :..**::. : *: : . : ..: :*. .. . : : :.:: *: :: . .. :. : . : *: :. .: : ::.:: * :: : :* : . * . : . ", "identical_positions": 10, "similar_positions": 63, "identity": "1.94%" }, { "cls_id": "homologset.agr.HGNC:17129", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0JPN2-1", "uniprot_id": "S39A4_RAT", "id": "A0JPN2-1", "name": "Zinc transporter ZIP4", "aln": "MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHS---DHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHSGEVHSHEEES-IGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGPC-----SHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q78IQ7-1", "uniprot_id": "S39A4_MOUSE", "id": "Q78IQ7-1", "name": "Zinc transporter ZIP4", "aln": "-MLPKSVTQGLVLALLVGTVAVARPRNLLSLLALGQGALDRLELDGLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALYLNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQPTGEKTCVDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPPNITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVWDTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQTERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEKDGPC-----SHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRLRAELRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6P5W5-1", "uniprot_id": "S39A4_HUMAN", "id": "Q6P5W5-1", "name": "Zinc transporter ZIP4", "aln": "MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLESPKALTPGLSWLLQRMQARAAGQTP-KMACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVP-MTLAELSALMQRLGVGREAHS---------DHSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSP--------QPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: **:**:** *.: * *****: ******: *.******. ****::*** ****** .*.**:*: . .* .***:*:: *****.***.:** **:* :*** ***.*. ** ****:*:* *** ***:::*: *.*.. : :***:******* **.. *.* **:****** .****:.************: **. :** **. **::**** * ** **** .* *. :*. . ...******:****:*:**.*****:***:*:*****:***:***** **:. . :******:**************************: * .****:**********:****:*** *********. * : *.******:*.*:* *****.:******** : :**** ********:****:**:***.* .**.**:***:**:******:.*** .***:***:********************:*:*******************************:*::************************.**.*:**********************::*** ******************:*********.***", "identical_positions": 451, "similar_positions": 116, "identity": "67.72%" }, { "cls_id": "homologset.agr.HGNC:1713", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LK58-1", "uniprot_id": "A0ABK0LK58_RAT", "id": "A0ABK0LK58-1", "name": "", "aln": "MCFPRGMLLQSLLPACPGCRPAPRALLCQPLPGRPPCGLSRWRPALSADPLAPRPLLLPQDSSEVAALSALRPLRKEFVPFLLNFLREQSSRVLP-QGPSTPAKTPGASAALPARQGA--------PPRGGR-GARSQLFPATEPLS-----------------------------------TSAEAPLARRAGRR------------RGPGP--SRERG-------GRGSGGPEEGASSESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKARSKQLQQSPTPACPAPDSGSP---VPNRTGNLTAEP----ADPARVSSRQRLELVALIYSSCIAENLVPNLFLELFFVLQLLTARRMAATKDSDL--ESSQGALDSLETPLFRSIHDCVFFAVQVLEHQFQVLSYLDKGTLKLLAENERLLCFSP----ALQGRLRAAYEGSVAKVSLVIPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPSWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGSVLGEAPDVLNMLGADKLGRLRQLQERLIAPQSSGGPCPPPTFPGCQGFFRDFIMSASSFHFNQHLMDSLSLKIRELNGLRLPQHEPGDEDGE----SDVDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYR---GHEPPPTRELQDSILALRSQVPPVLDIRALLQQGLWARRAVLTVPWLVEFLSFADHIVPLLDYYRSVFTLLLHLHRSLVLSKENEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEDGQVDAFEVDTTTSEHGLDSVPVVDQ-------QLLYTCCPYIGELRKLLASWVSGSSG-------RSGGFVRKITPTTTTSLGTLPLKTSQGLQAQLAEAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQEQLVTRGQEGGDPAQLLEFLCSQLCPHGAQALTQGREFCQKKSPTALRALLPEETPAAVLSSAENIAVGLATEKACSWLSANIT--ALIRREVKAAVSRMLR------------AQGPEPTARVERRG--------CSRACEHHAPLPSHLISEIK-------DVLSLAAGPRDPEEGVSPEHLEQLLNQLGQSLKCRQFLCPTAEQHLAKCSVELASLLVADQIPILGPPTQHRLDRGHARRLLHMLLSLWKD----DFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKDLMGHLEIEACLVSLNEAQWPGDFSEELSTLFRLFLAEPHLLEPQLRACELMQPNRGTVLAQS------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CC12-1", "uniprot_id": "CDAN1_MOUSE", "id": "Q8CC12-1", "name": "Codanin-1", "aln": "MAAVLESLLREEVPVAAAVRWIARSTPSS------------------------------EDSSEVAALSALRPLRKEFVPFLLNFLREQSSRVLP-QGPSTPAKTPVASAALPARQGA--------PARGGR-GARSQLFPAAEPLS-----------------------------------AAAEAPLARRAGRR------------RGPGPGPSRERG-------GRGSGAAEEGASGESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSTLDTSPWGLGLPPGCRSLQEEREMLRKARTKQLQQSPTPASPIPESGSP---VPSRTGNLTAEP----ADPARVSSRQRLELVALIYSSCIAENLVPNLFLELFFVLQLLTARRMVATKDSDL--ESSQGALDSLDTPLFRSIHDCVFFAVQVLEHQFQVLSYLDKGTLKLLAENERLLCFSP----ALQGRLRAAYEGSVAKVSLVIPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPSWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGSVLGEAPDVLNMLGADKLGRLRQLQERLIAPQSSGGPCPPPTFPGCQGFFRDFIMSASSFHFNQHLMDSLSLKIRELNGLRLPQHEPGDEDGE----SDMDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYR---GHEPPPTRELQDSILALRSQVPPVLDIRALLQQGLWARRAVLTVPWLVEFLSFADHIVPLLDYYRSVFTLLLRLHRSLVLSKENEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEDGQVDAFEVTTTASEHGLDSVPVVDQ-------QLLYTCCPYIGELRKLLASWVSGSSG-------RSGGFVRKITPTTTSSLGALPLQTSQGLQAQLAEAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQEQLVARGQEGGDPAQLLESLCSQLCPHGAQALTQGREFCQRKSPTAVRALLPEETPAAVLSSAENIAVGLATEKACSWLSANIT--ALIRREVKAAVSRMLR------------AQGPEPTARVERRG--------CSRACEHHAPLPSHLISEIKFHHCSLQDVLSLAAGPRDPEEGVSPEHLEQLLNQMGQSLRCRQFLCPTAEQHLAKCSVELASLLVADQIPILGPPTQHRLERGHARRLLHMLLSLWKD----DFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKDLMGHLEIEACLGRLNEAQWPGDFSEELSTLFRLFLAEPHLLEPQLRACELMQPNRGTVLAQS------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IWY9-2", "uniprot_id": "CDAN1_HUMAN", "id": "Q8IWY9-2", "name": "Codanin-1", "aln": "MAAVLESLLREEVSVAAVVRWIARSTQGSE-----------------------------DNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLP-QGPPTPAKTPGASAALPGRPGG--------PPRGSR-GARSQLFPPTEAQS-----------------------------------TAAEAPLARRGGRR------------RGPGP--ARERG-------GRG---LEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTG-TKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSP---LPSRTGSLTDEP----ADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDP--ELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSP----ALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGE----SDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYR---GPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQ-------QLLYTCCPYIGELRKLLASWVSGSSG-------RSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSANIT--ALIRREVKAAVSRTLR------------AQGPEPAARGERRG--------CSRACEHHAPLPSHLISEIK-------DVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKE----DFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8N7UT82-1", "uniprot_id": "A0A8N7UT82_DANRE", "id": "A0A8N7UT82-1", "name": "", "aln": "MAALLESVLQSKVELSEAVLWLKGLHVCE------------------------------------SQNFPSRVTKEEFVPFLLNFLRDQSSQTLT-HGPATPAKTPSTSRSVRIQNSSERRVSKSTPVQGLRSASRVQLFSPAPFTSPGGGKNDQDTPFTGSLCLSGISALSSPSFSSVWSPVPRNSPSERRSAQRPSLGDFMTSPPETQPSPSAPPHRGRRRSAGFGGGTSSRQTGARGAVSEEGGGRRSRGGGRNDSVSPQTQVQLNFNNLEDFPPMAQPSP---IATKPSRRINPTPVSAERPNSKPKSCFTSTPLS-LPASPPKIPEST----GSP---HNLQEERELLKRERSKLAQQTSSPLKTNSEICTPTKTVHMQGSKVTPDSQLPCPDPDKVTQKSELDLLAGLYCACISENLVPCIFLEMFFVLQLLTSRGVSGSESAEQGISVCEDSPDVLEKAYLGNVHNCVYFSVRVLEKQFELVSHLDKCTLRLLSENERVGTFSS----SLKDCLAEAQDNCTAKVPPSPPLFVHSVPFQPATDNRSNFSSDKAFHTFKKQRDVFYGLLREWEDSHKEPGWDFEAALGNRVRMMVSQLTAAGSQSHFARLFQKQLVQMCKGPSVLASSSDAPDADLLGMLGADSLGRLKRLQQRLVQPQSLIGPCPPPSFPGHQEFFKGFLQTASSCQLNQHLKDGLCQQLLKLDEVSILGPDASPAQGEKTADGDMEQQDEKQRFSSVLLTARLLAKFLGFITFLPYQ---TSELP-SRDIQDAAVALRSKSFPVLDVCTVLRNSVHRRRTILTVPWMVEFLSMLDYIGPLLPCYRTALCLLLQIYKRMVLGRG--GELCYMNQLLMVAVLGWLFQIPVFPEDLFFSADLKEEMKELENKTSSQGLDTLPLVDQ-------QLLYTCCPYLGEFRKLLAAFVAGSTS-------KSGGLIRKITPTSAEPRGPSTTRSQQKLQVDLEQAFFHNQPPSLRRTVEFVAERVGSNCVKHIKATLVLELVRGGEKTLRDSL---GMEGVNTAKLNDCICAQLCDAGMQALERATRFCSENAPGAVRVLLPLETSPSVLTTAKSITTRLATEKACSWLSSNIT--TLLKREWKSAFERVMKSVPSPLSVDAEEAEGLSRSQQVQKSASGLSAGSTCVPGCAHKVPLGSEVMIEIK-------DVLSVAVGPRSDDEVFTVRQIESVLDRVGQTLGCRKRLSPVVEQMLLRCTVQLACKLVSGELPLVSS-----AEGNKRPDLLERFLVLWS------WTPAPPLHLLLTEPTLTAIFTATDRERTDYLFLIRQLIERGLLGEQEVGTNWAKLSALSWP---EESVEKFQQLSLATQFSMPQLPNHRDLLQVSQ-------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8T626-1", "uniprot_id": "DLT_DROME", "id": "Q8T626-1", "name": "Protein disks lost", "aln": "MTAELKASDTEMTKPEERHLLQLLAQLEKVP------------------HHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTT----------------------------------PAPQQPQGRRSTPG------------SGAQFCSTPNRS-------GGG------GAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSAS---SSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLK---KQEIKSEAPVNVSQQERTP------EDEVFPEEA----ISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQS-------PVKSYVPSALEG--LTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELG---------LKLDPLRHNKLAQRLVTSSSSVEG-----QFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVE---EQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIAR-----SCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQ--ELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCN----------------------------------CNRNKADAAAAGGGGSSELQLS-----PDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . . . ::*..::*. **:.:.: :.. **. . . : . . :* . .: : . : * **. . . .*. * * *. . *. . : .: :. . . . :** **: * .:* : . * :.* ... . ::: .:: .: :* : * :: :* : :* . .. :. . *:. ..*:*:: :*. : **** :: *: **.:**. * . : . *: : . :.**:*:.::** : ::: *** ** :* :***: :. *: :. .. . . : * :: .*.* **.*:. * :**.***:** *:.** * : .::* ** *: : : . . :*:.:** :**: . . * * * : *. : ..* * ** * **:.*: .** : ** * :: . : : : . : *. .: . :******:::.:*: * . : : **.: * ::: :*...: : ::*:**:*::*:: * : * : ** :: : :.: . : . : :***:: : :: . . *. . *: :** ..**:: *:* ::. ..:. : : :: :. : . . . : * .* :*:::.* .* ** :***:** . **. : :: .: :.: * : :* : : : .: ... :: *** .* . : :: : * : **.:.: :: : : : : . * . .. . *:: :..: . : . :. :*. : * : * : *:.. : : :: :* . : * .. . ::*.::: . : .: * .*. : : . : : . ", "identical_positions": 169, "similar_positions": 354, "identity": "12.03%" }, { "cls_id": "homologset.agr.HGNC:17133", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M9PWS6-1", "uniprot_id": "A0A8M9PWS6_DANRE", "id": "A0A8M9PWS6-1", "name": "", "aln": "-------------------------MGVIDQMELDFLTNQQLLSFFRRKKTEI-SCIEQPHIFLTQLRDYDLLPEPLFEKVKKMHK--------------------RDQKQKGVYEVLDWLEKERSQHMHRFWRCVFKDHIVQKYPTLCLLKNSLPDAVISFSEEPADAETPTKESEVTEKKEKPRKNTRKRIRDDQSSEDSGDPGPSSASTPTRKKPAKKPSFSSPVKKGDNQE-------------------IWMFPIYKTQLPVKCGDKEGTLYRDKLPKGEKCILA--QGRWFSPSEFEK---------------FAGKEKTKNWKVSIRCRN----TPLKKLIEENHLQCPPMERRKRKCVQKNKTELCCISSSESSSLDSETSASSEEESDAEDFQEESRSSGGGSQFRSRVHEEEEEEEDEMADLT------------------------------------------------------------------------------------------------------------------------------------------------------VFQAPTLQVTCVSLTGTLYKGRFATGRRGKCIRTEER-WFTPEEFVKEEPTLTDGLWKRDILCHGKTLNFLCKKKILQIHS-----LLCECVKCSTDPEDLMEQNNDDVCYACHCGVDLRCCDGCPRAFHSDCHLPAVPE--GSGEWICTFCVLKTSLQWRASSNMTEQEAFDSPVS-QYILQCHYLLLCMYKEDIQRVFVEDPRPN-VDRYSEFISQPMWLDRIKSKLESKKYQKFGEFVSDFRLIFSNCKNFNKDNEFGQLGAKLKEIFEEEIQKIFFIQ------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PDW0-1", "uniprot_id": "A0A8M9PDW0_DANRE", "id": "A0A8M9PDW0-1", "name": "", "aln": "---------------------------MEFNGQMDFLTDEQLLSVFHLKKTEI-SCIEQPLIFLTQLRDHNLLPETRFKKVKGMRT--------------------REQRQQGVYDVLEWLERERSQDIRRFWRCVFEDHIVQKYPTLHLLRKSLPETVTKFSEERIGIETLTENSGQKEKN-----GTYNRKRNDRSD----DPGSS----------AKKPSFS-PHEKGSKER-------------------IWMLSRYKTQLPVKCGDKEGILYRDKLAKGEKCIREGAQGRWFSPSEFEK---------------FAGKESSRNWKASIRCDG----TPLKKLIEENHLQCPPMKNRDRTSVRKSKKNIS-ISSSESSSTDSETSASSEEESEAEDVQKQSKRAGLRSQFRSGVDDYGEEE-DEMVDLT------------------------------------------------------------------------------------------------------------------------------------------------------VFQAPSLPVSCVSLIGTLFKDRFATGRCGKSIRTKQH-WFTPEEFVKEEPTLSDGLWKRDILCHGKTLNFLCEKKILDIHP-----KNCTCVKCSTNPDDLMDQNNDDECNVCHSEGNLVCCDKCPRAFHPDCHLPAVNEEDSAWQWICTFCMLRTRQRGCASRNMTEQEAFDVPIS-QCRLQCHYLLLCMYNEDIQKVFVKDPRPN-VRRYSEFISDPMWLNRIKQKLKDNMYQKFGEFASDFQLIFSNCRKFNRDNKFGQLGAKLKEIFEDEIQKIFFIQ------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58IRC7-1", "uniprot_id": "A0AC58IRC7_DANRE", "id": "A0AC58IRC7-1", "name": "", "aln": "---------------------------------------------MKKK-----SCKKS-----RQIRSSSICSSKRKKQAKSKN----------------------------------CLQSSSSQ---------------------------------------------------------------------------------------------------------------------------------------SRLPVTCGYKEGLLDLKKYYKRQKCILS--EDRWFTPTEFER---------------FGRKEKNKKWRTSILCKG----ITLQKLIEDGFLLPKTFMKG-RIHGEKQKK--------RPEVLQQQVVLESAEKSNGS-----------------------QGEDDDDIDMT------------------------------------------------------------------------------------------------------------------------------------------------------KFEGATLPVACGSNSGVLHKCRFAGERCGRCIRTENS-WLTPEGFIKLN--KPDGIWRKDIVSNGVPLGRLIKKKVLELHT-----INCDCEIC----QELDQHLNDDVCFVCNSEGNLVCCDECPRAFHHHCHLPAVPE-DSSGKWSCIICVLKNMK---GSSQKNQQDIMSSPVS-QYTQHCQCLLLHLLRECMT-----DPCTN-IPGGSENICGPMMLGRVKQNLENNNCPTVQVFVSDIEYVFHHCTSK-RDNDFSRMMSRLMELLETIFKP-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q13342-1", "uniprot_id": "SP140_HUMAN", "id": "Q13342-1", "name": "Nuclear body protein SP140", "aln": "MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLESNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEA--ERTPWNCIFCRMKESPG--SQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQETNGNN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: : *. :*. .: .. :: : : : : . * :** * : :: :.* . ::: : : . . * * . . ..* . . : . . : .: .. * .:.. * .: ::: *:.. * *:* . * *.* :: :.*:*:: *:** * . *: .: . * .* * :: .* . . . * * * .*. :* *** *.*.** .**:*.* * * :* :: .. :.: :. :. : :*. *** : * : .: : ** *.::*..*:.: . *..*:. :* : : :.*.:: :* :* :: ", "identical_positions": 65, "similar_positions": 133, "identity": "7.46%" }, { "cls_id": "homologset.agr.HGNC:17134", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99MB4-1", "uniprot_id": "ZNG1_RAT", "id": "Q99MB4-1", "name": "Zinc-regulated GTPase metalloprotein activator 1", "aln": "MLPAMKTVEAEEEYAED-CPELV-------------------------PIETKHQEKEENLD------FIIKIPVTIVTGYLGAGKTTLLNYILTEQHNRKIAVILNEFGEGSAVEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLKAIENLMQKK-GKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITVVDSKYGLKHLTEE-----------KPDGLVNEATRQVALADMILINKTDLVSE--EELNKLRTTIRSINGLGKVLETQRSRTHLSNILDLHAYDTLSGISLQKKLQHVS-TAPHLDQSIVTVTFDVPGSAEEESLN-----VFIQNLLWEKN--------VKNKDGRCMEVIRLKGLVSIK-DKPQQMIVQGIHELYELEESRVNWKDDAERACQLVFIGKNLDKDILQQLFITAVAETKEQTTAPGQ-DGACPPH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VEH6-1", "uniprot_id": "ZNG1_MOUSE", "id": "Q8VEH6-1", "name": "Zinc-regulated GTPase metalloprotein activator 1", "aln": "MLPAVKTVEAEEEYAED-CPELV-------------------------PIETKNQE-EENLD------FITKIPVTIVTGYLGAGKTTLLNYILTEQHNRKIAVILNEFGEGSAVEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKK-GKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITVVDSKYGLKHLTEE-----------KPDGLVNEATRQVALADMILINKTDLVSE--EELNNLRTTIRSINGLGKVLETQRSRVHLSNILDLHAYDILSGISLQKKLQHVS-TAPHLDQSIVTVTFEVPGSAKEECLN-----VFIQNLLWEKN--------VKNKDGHCMEVIRLKGLVSIK-DKPQQMIVQGIHELYDLEESLVNWKDDAERACQLVFIGRNLDKDVLQQLFLTAVAEAEEQRTAPGR-DGVCPSH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BRT8-1", "uniprot_id": "ZNG1A_HUMAN", "id": "Q9BRT8-1", "name": "Zinc-regulated GTPase metalloprotein activator 1A", "aln": "MLPAVGSADEEEDPAEEDCPELV-------------------------PIETTQSEEEEKSG------LGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKK-GKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEE-----------KPDGLINEATRQVALADAILINKTDLVPE--EDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLN-----MFIQNLLWEKN--------VRNKDNHCMEVIRLKGLVSIK-DKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0R0B1-1", "uniprot_id": "ZNG1_DANRE", "id": "B0R0B1-1", "name": "Zinc-regulated GTPase metalloprotein activator 1", "aln": "-------MEDEDE-----CPELV-------------------------PIK------EKPSG------PTAQIPVTIITGYLGAGKTTLLNYILTEQHNKRIAVILNEFGEGSALEKSLAVSQAGELYEEWLELRNGCLCCSVKDNGLKAIENLMEKK-GKFDYILLETTGLADPGAVASMFWVDAELGSDVYLDGIVTVIDAKYGLQHLTEE-----------KPEGLINEAARQIALADLTIINKTDLVHE--TELLKLRDTVRSINALVKILETQKSRVDLSEVLDLHSFDTKDGERLTKKLQLVKTSQPHLDKSMLTITFEVPGSVSEDLLN-----IFIQELLWEKT--------FKNKAGLPMTVIRLKGILSLQ-QKQKKVMLQGVHELYELEETPEFWADQEPRLNRLVFIGRNLDGEILKKEFISAVSNKDSVE-------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53729-1", "uniprot_id": "ZNG1_YEAST", "id": "P53729-1", "name": "Zinc-regulated GTPase metalloprotein activator 1", "aln": "-MSALRNIKFNEEEDGE-LPCLVTGEENNLQEILENVSYDGGNIVSDAKVERVNKQVENTSAGATDVHEKKRIPVSIITGYLGSGKSTLLEKIALKGADKKIAVILNEFGDSSEIEKAMTIKNGSNSYQEWLDLGNGCLCCSLKNIGVKAIEDMVERSPGKIDYILLETSGIADPAPIAKMFWQDEGLNSSVYIDGIITVLDCEHILKCLDDISIDAHWHGDKVGLEGNLTIAHFQLAMADRIIMNKYDTIEHSPEMVKQLKERVREINSIAPMFFTKYSDTPIQNLLDIHAYDS---VRISDILDSGSGNGTIHDDRMGTIMLTFRPLKNEEEYNNKFIKQFLQPLLWKNFGAMTVLGGRRRDDGRDWEVQRTKGLILIEGENPIARVIQGVRDTYDVFPG---KYDGSNKECKIVLIGKYLEKESIEELLRKTLE-------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . ::: * ** :: *: :***:*:*****:**:***: * : .:::********:.* :**::::.:..: *:***:* *******:*: *::***:::::. **:*******:*:***..:*.*** * *.*.:*:***:*::*.:: *: * : :* :. * *:*:** ::** * : . : :*: :*.**.: :: *: * . :.::**:*::* : . *: . . *. : *: : . .*: * *:* ***:: :.. . * * **:: :: :: ::**::: *:: * : ::*::*: *: : ::: : :: ", "identical_positions": 115, "similar_positions": 134, "identity": "25.22%" }, { "cls_id": "homologset.agr.HGNC:17135", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BFS3-1", "uniprot_id": "REL3_RAT", "id": "Q8BFS3-1", "name": "Relaxin-3", "aln": "MA-TRG-LLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVG--------SSE---WLALTKSPQVFYGGRSS--WQGSPGVVRGS----RDVLAGLSSSCCEWGCSKSQISSLC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CHK2-1", "uniprot_id": "REL3_MOUSE", "id": "Q8CHK2-1", "name": "Relaxin-3", "aln": "MA-MLGLLLLASWALLGALGLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHESLGDFFADGEANTDHLASELDEAVG--------SSE---WLALTKSPQAFYGGRAS--WQGSPGVVRGS----RDVLAGLSSSCCEWGCSKSQISSLC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WXF3-1", "uniprot_id": "REL3_HUMAN", "id": "Q8WXF3-1", "name": "Relaxin-3", "aln": "MARYMLLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVIFTCGGSRWRRSDILAHEAMGDTFPDADADEDSLAGELDEAMG--------SSE---WLALTKSPQAFYRGRPS--WQGTPGVLRGS----RDVLAGLSSSCCKWGCSKSEISSLC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q7S0-1", "uniprot_id": "A0A8M9Q7S0_DANRE", "id": "A0A8M9Q7S0-1", "name": "Relaxin-3", "aln": "MCRVAVLVFGLLVALLG--GAQATDGHSIYGVKLCGREFIRAVIFTCGGSRWRRS-LDDSGDLSSDLLSAHDDEASERWALNSVIPGLSYRPRPNSETPSWAAEASEGPVFSRTARSVISEEVLEALRTSDRKGRDVVVGLSNACCKWGCSKSEISSLC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*. :: .* * * : ***:*********************: : :.. : ... : *:..: .** * * :.. .* * : .:* * ***:.***.:**:******:*****", "identical_positions": 56, "similar_positions": 34, "identity": "35.22%" }, { "cls_id": "homologset.agr.HGNC:17136", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5RJT2-1", "uniprot_id": "SPB1_RAT", "id": "Q5RJT2-1", "name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "aln": "MGKKGKVG-KSRRDKFYHLAKETGYRSRSAFKLIQLNRRF-QFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGCFITKVFRSRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFVVCQGFLAPDKVDAKFFDPKFAFKEVEVQAKTVTELVT---KKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEISIDD-----KELAQHPATTEDIRACCQDIKVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSEEE--GDEEESAA-ETKQASEEEEEREEEEQLNRTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPG-VSIADE--GETGMFSLRTIRGQQLLEEVT--QGDMNAADTFLSD----LPRDDIYVSDAEDD-DDTSLESDLDPEELAGVRTHSD----QKEQKSLQFAQVDDSKE--------EEGE-NPLLVP--LEEKAVLQEEQASLWFSKDGFSG--IDDDADEALEISQAQLLYKSRQKEQQPTD----PPPPPTNLKTEKKSSQCQNEVPKETEAIT------DTGGEDR-DSSDSDSS-SSEDEDDWKVSRGKKRSRGSK--ADEDGFEVVPIEDP-VKYRILDPEGLALGAVIASSKKAKRDLIDNSFNRYAFNEEEEELPEWFVQEEKQHRIRQLPLDKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKKLEQTKKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKR-QVTYVVAKKG-VGRKVRRPAGVRGHFKVVDSRMKKDQRAQ-RKEQKRNHRRK----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DBE9-1", "uniprot_id": "SPB1_MOUSE", "id": "Q9DBE9-1", "name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "aln": "MGKKGKVG-KSRRDKFYHLAKETGYRSRSAFKLIQLNRRF-QFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGCFITKVFRSRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFVVCQGFLAPDKVDAKFFDPKFAFKEVEVQAKTVTELVT---KKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEISIDD-----EELAQHPATTEDIRVCCQDIKVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSEEEEEGDEEEAVA-ETKQAPEEEEEREEE-QLNRTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPG-VSIADE--GETGMFSLRTIRGQQLLEEVT--QGDMNAADTFLSD----LPRDDIYVSDAEDD-DDTSLESDLDPEELAGVRTHSD----LKEQKYLRFTQVDDNKE--------EEGE-NPLLVP--LEEKAVLQEEQASLWFSKDGFSG--IEDDADEALEISQAQLLYKSRQKEQQPTD----PPPPPTNLKTEKKSPQGQNEVPKETEAILGTEAVTDPGGEERGNSSDSDSS-SSEDEDSWKVSRGVKRGRGSK--ADEDGFEVVPIQDP-VKYRILDPEGLALGAVIASSKKAKRDLIDNSFNRYAFNEEEGELPEWFAQEEKQHRIRQLPVDKKEVEHYRKRWREINARPIKKVAEAKARKKRRVLKKLEQTKKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKR-QVTYVVAKKG-VGRKVRRPAGVKGHFKVVDSRMKKDQRAQQRKEQKKKHKRK----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IY81-1", "uniprot_id": "SPB1_HUMAN", "id": "Q8IY81-1", "name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "aln": "MGKKGKVG-KSRRDKFYHLAKETGYRSRSAFKLIQLNRRF-QFLQKARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVT---KKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDD-----EELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPG-VSIADE--GETGMFSLSTIRGHQLLEEVT--QGDMSAADTFLSD----LPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQG----LRDQKRMRLTEVQDDKE--------EEEEENPLLVP--LEEKAVLQEEQANLWFSKGSFAG--IEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPK--SDDDGFEIVPIEDP-AKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKR-HVTYVVAKKG-VGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IDS8-1", "uniprot_id": "A0AC58IDS8_DANRE", "id": "A0AC58IDS8-1", "name": "pre-rRNA processing protein FTSJ3", "aln": "MGKKLKVG-KTRKDKFYHLAKETGYRSRSSFKLIQLNRKF-QFLQKARALVDLCAAPGGWLQVASKFMPVSSLVIGVDLVPIKPIPNVVTLQEDITTEKCRQALRKELQTWKVDVVLNDGAPNVGANWQHDAFSQANLTLMALKLACEFLAKGGTFITKVFRSKDYQPLMWIFQQFFKKVQATKPQASRNESAEIFVVCQGFLAPDKIDNKFFDPKHAFKEVDVQVKTVKELVN---KKKPKAEGYSDGDLTLYHKFTITEFLKAENPVDFLSKANEITFDD-----PLLESHPLTSAEIRECCSDVKVLGRKELRLLLSWRSKLRKFLAKKLRQEAKQLDQEASSDDEQSDTDEKESK--KKKSEEKKEEEDEDEAMEKKLTELKAEEFAELKRKKKKLLKERRKQRERVELKMDLPG-VSIADA--GDSSMFSLGSIRKSQGLHQLA--QGDMSAADALLED----DEQEDVHLSDEEQEDERMSLASDLDSDDLQEIQQKEEQMLKNKPKKKKKVSFEQQDDG--------DEDNKNELLVE--LEGKDERKERETSMWFSKDIFAELDLNDDTDAMNELKQTQILQTGRGKKRKAQQ----------EEEAEPKKPEQKVATP----------------SQEVKEAEDSDSDDSSDDEREIAQMKQASAAVGTNGAEENDNIQVIPVEKTNKRARVLDAEGLALGAQIATSKKRERDLIDGSFHRFANSEDMTEVPAWFVDDEKKHRKRPVPVTKDMVEEYKQKWKEINARPIRRVAEAKARKKRRTLKKMEQAKKKAEAVVNTVDISEREKMAQLKSIYKKAGVGKEKR-EVTYVVAKKG-VGRRVRRPAGVKGAFKVVDGRMKKDTRAAQRKDERGRGKGGRGSKGMKGGRGPKGGRGMKAGKGRPNKK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VXK5-1", "uniprot_id": "Q9VXK5_DROME", "id": "Q9VXK5-1", "name": "Putative rRNA methyltransferase", "aln": "MGKKTKVG-KTRKDKFYQLAKETGLRSRAAFKLIQLNRKF-GFLQQSQVCLDLCAAPGGWMQVAKQNMPVSSIVIGVDLFPIRPIAGCIGLVEDITTEKCRQSLTKELQSWKADVVLHDGAPNVGRNWLYDAYQQICLTLNALKLSTQFLRNGGWFVTKVFRSKDYNALLWVLKQLFKKVHATKPSASRKESAEIFVVCQGYLAPDHIDPRLLDSKYVFEELDLDAKKKSSLLHPEKQKRIKAEGYTAQDIALRNDLAATEFLKAENALAALQGIGSIRIDD-----QRIANHKKTTPEILECCKDLKVLGRKDIKGLVQWWKDVR----ELFVEKETPLVVGNAADEK------------PKPLTQAEIEDMEDAELQTQIETIVEEEKKDLKRKRKKTLKTKAKLHEKMNLNMVIKGDDGPVEE--MEHEIFDLKNIRTSAELDELLDVQPDFAVDESQPEETK--LPKYKYFDKDEGNINDDLNYDDDNDEEQSEASDDEDQ----INDKQGLGLSDDDNDEGNAKGKNKRKKRSENPLIKSNDFRDKNTKREQRVQLWYEKDVLQN-IQSDDDEETYDLNNLAKEFKAKGVAVLGES----------TLTPDANEEVVQGKKAKRR-------------ARHETATKDSSSESSESEDDANEDSDGEQPAAGTN-----------------AKKVRLSENEMALGALLTRSKKTRRDLIDAAWNRYAFNDE--NVPVWFKLDEDEHMTKPTPVPKELTAEYQRKLQEVNVRPIKKVMEAKARKHRRATKRLAKAKKMAEKIMENSDATNHEKSKQLKKVYKKA--QEKKK-EVTYVVAKKQTAARRARRPAGVKGRYKVVDPREKKDKRSMDAKKRREKGSKGRKGKGRK---------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25582-1", "uniprot_id": "SPB1_YEAST", "id": "P25582-1", "name": "27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase", "aln": "MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASKLCPVNSLIIGVDIVPMKPMPNVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLVVNGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKRLDPRLLDPKEVFEELPDGQQNMESKIYNPEKKVRKRQGYEEGDNLLYHETSILDFVRTEDPISMLGEMNKFTIDENDHEWKILKKLKQTTDEFRSCIEDLKVLGKKDFKMILRWRKIAR-----------EILGIEVKDDAK---------------TEIEVVPLTEEEQIEKDLQGLQEKQRLNVKRERRRKNEMKQKELQRMQMNMITPTDIGIEAASLGKESLFNLKTAEKTGILNDLAKGKKRMIFTDDELAKDNDIYIDENIMIKDKDSAADADDLESELNAMYSDYKTRRSERDAKFRAKQARGGDNEEEWTGFNEGSLEKKEEEGKDYIEDNDDEGVEGDSDDDEAITNLISKLKGQEGDHKLSSKARMIFNDPIFNNVEPDLPVNTVN------DGIMSSESVGDISKLNKKRKHEEMH----------QKQDEADSSDESSSDDSDFEIVANDNASEEFDSDYDSEEEKNQTKKEKHS-RDIDIATVEAMTLAHQLALGQKNKHDLVDEGFNRYTFRDT-ENLPDWFLEDEKEHSKINKPITKEAAMAIKEKIKAMNARPIKKVAEAKARKRMRAVARLEKIKKKAGLINDDSDKTEKDKAEEISRLMRKVTKKPKTKPKVTLVVASGR-NKGLAGRPKGVKGKYKMVDGVMKNEQRALRRIAKKHHKKK-----------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***. * . * * *::* ****.* *:*::**:**:*.:: **::::. :*******.* *** : **.*:::***:.*::*:.. : : .***** **. * :::**.*.**:******* .* **: * *** **:*: : * .* *:**:***:**: *:*:::*:*.:*.**** ***: ********:*: **.::* :::*.* .*:*: :. . : :* * :** * * : : :*::: :.: * ..: .*: : . *: :: * .*::***:*::: :: * . * * : *: :: : : :: ::**:::: . : * ::::::* . . :*.* . . *.:: : : : . . .* . : . .: : .. . :: :: .: . : : . : : . : ... . : .: : .. ..*... *...: . ... : ::*. :: .:* .:**:* .::*:: : ::* ** :*.:* *: *. . :.: : :*.***::* ******: * :: : :* * : : * ::::* :: : :*. :.: .** ***. . ** **:* :*:** *:: *: .: . ", "identical_positions": 184, "similar_positions": 255, "identity": "20.11%" }, { "cls_id": "homologset.agr.HGNC:17142", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R5M4-1", "uniprot_id": "OPTN_RAT", "id": "Q8R5M4-1", "name": "Optineurin", "aln": "MSHQPLSCLTEKGDSSCETPGNGPSNMVHPNLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHENERLKEELGKLKEKSERPFEDITGRCGFPRTDLEQEVEQLKRQVEQEVEHLKIQVRRLQAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGEAEGAMKEMRNSAGPTRTDSIS------MGKCTEDARTCVEFEELTVSQLLLCLREGNQKVERLEIALREAKERISDFEKKANGHSAIETQTEGSTQKE-EEDKDPESVGIEVETLNVQVASLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNRKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHDKLLQEHNKALRTIEELTKQQAEKVDKVQLQELSEKLELAEQALASKQLQMDEMKQTIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDFEDGGS---RQSLMEMQCRHGARTSDSDQQAYLFQRGAEDMSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDCII--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K3K8-1", "uniprot_id": "OPTN_MOUSE", "id": "Q8K3K8-1", "name": "Optineurin", "aln": "MSHQPLSCLTEKGDSPCETPGNGPSNMVHPSLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERLLFEMQSKEVKERLKALTHENERLKEELGKFKEKSEKPLEDLTGGYRYPR-ALEEEVEKLKTQVEQEVEHLKIQVMRLRAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGETEGAMKEMKNCPTPTRTDPIS------LSNCTEDARSCAEFEELTVSQLLLCLREGNQKVERLEVALREAKERISDFEKKANGHSSTEKQTARRADRE-KEDKGQESVGSEVETLSIQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHNKLLQEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQMDEMKQTLAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDIEEGGS---RQSLMEMQCRHGARTSDSDQQTYLFQRGAEDRSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDCII--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96CV9-1", "uniprot_id": "OPTN_HUMAN", "id": "Q96CV9-1", "name": "Optineurin", "aln": "MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPR-----------AEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGG----RQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWR---QQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5RI56-1", "uniprot_id": "OPTN_DANRE", "id": "Q5RI56-1", "name": "Optineurin", "aln": "-----------MNGDISHPRGSGPGNLG-------SLEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVENEALKNQVKELEKSGAECLHT-------------------------ELEALRGQILRIQAEKNDLVAMNSELQLKMGQ-GSPSNSFIEIRIADDDLK-VTKDLSSVP-----------------EASAFSMPKAESEEQTVRQLLRSLRAETDEKERLQLTLQEARGRIAELESKLEHADSSAQTSLPSAAET--------NASTEVKNLEDQLLKLCNELKQAQIKLDEAESMKRNLQDRCKDLEQDLGTLKTQLGDKQKVQAENDCLKVQMESLQAAIKLEQKKTQDEKNNLNQLKDAYTKLFEDYS----ELQEEKKKRESCVSKDDYDELQTRFATAEKALADKQQKIDEMKMELFQKEKDLETISVFQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVKKQNSQLQEEMESLGRHSMSEMQRRHVPRGANPQGPTAPNNLPGGRGEWQ----QQNIPDHACPKCGEVLPDLDSLQIHIMDCII--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9GYV5-1", "uniprot_id": "NEMO_DROME", "id": "Q9GYV5-1", "name": "NF-kappa-B essential modulator", "aln": "----------------------------------MSDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAEETVASTSTQPPTVNCIPVSITASQQQHKSLDS--------------------------------------------------------------------------------GSSQQQSLATSFIMGEIQSDVLKN---------------------------------SVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKVN------------------------------------------------QTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQELKRDLETKIEQIEGVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKLKQLN-------HSFEFVPEYATESKSQELIKKMQLDINELKARDIQKQ---EVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALA---ESHKASKACSTASPLSSSRSNLREEQRPILDPTGAS--SRTSDTTLRCPICSKSFNALSVLQSHVNDCLDKN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ** : : .. ..::: . . * * ...* : : : :: **..:. : : .: : . . : * .*: :: :*: : * : ::. : *. : :: *: .. .: : : * *: ::*: *: : .*:..* .*::: ::: . ::: : . * .::*:* ::: *.: :: * ::* ** *** *** **:: :* : :.*. : : . . . :.. : . . ** *.: : :. ** *: **: ", "identical_positions": 46, "similar_positions": 116, "identity": "7.71%" }, { "cls_id": "homologset.agr.HGNC:17144", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JM14-1", "uniprot_id": "NT5C_MOUSE", "id": "Q9JM14-1", "name": "5'(3')-deoxyribonucleotidase, cytosolic type", "aln": "-----------------------------------------------------------MAVKRPVRVLVDMDGVLADFESGLLQGFRRRFPEEPHVPLEQRRGFLANEQYGALRPDLAEKVASVYESPGFFLNLEPIPGALDALREMNDMKDTEVFICTTPLLKYDHCVGEKYRWVEQNLGPEFVERIILTRDKTVVMGDLLIDDKDNIQGLEETPSWEHILFTCCHNQHLALPPTRRRLLSWSDNWRGIIESKRASL---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZWR1-1", "uniprot_id": "D3ZWR1_RAT", "id": "D3ZWR1-1", "name": "", "aln": "MLHRSCSPSRDAMSSWVPSWSLMQMIRVGPAHTLVPEACFRVWHPRCLLRCSAETPGVAMAVKRPVRVLVDMDGVLADFESGLLQGFRRRFPGEPHVPLEQRRGFLASEQYGALRPDLAEKVASVYEAPGFFLNLEPIPGALDALREMNAMQDTDVFICTTPLRKYDHCVGEKYRWVEQNLGPQFVERIILTRDKTVVMGDLLIDDKDNIQGLEETPSWEHILFTCCHNQHLALPPTRRRLLSWSDDWRGIIESKRASL---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8TCD5-1", "uniprot_id": "NT5C_HUMAN", "id": "Q8TCD5-1", "name": "5'(3')-deoxyribonucleotidase, cytosolic type", "aln": "-------------------------------------------------------------MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHLGPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRLLSWSDNWREILDSKRGAAQRE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *.***************:***:******* ************** *** *******:*******:*****:**********:**** : **:*****:** **.************:***:**************:*********.::* ****************:**.*************:** *::***.: ", "identical_positions": 163, "similar_positions": 25, "identity": "62.21%" }, { "cls_id": "homologset.agr.HGNC:17145", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60192-1", "uniprot_id": "SNAPN_RAT", "id": "P60192-1", "name": "SNARE-associated protein Snapin", "aln": "-MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDS-GVYPPGSPSK-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z266-1", "uniprot_id": "SNAPN_MOUSE", "id": "Q9Z266-1", "name": "SNARE-associated protein Snapin", "aln": "-MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDS-GVYPPGSPSK-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95295-1", "uniprot_id": "SNAPN_HUMAN", "id": "O95295-1", "name": "SNARE-associated protein Snapin", "aln": "-MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDS-GIYPPGSPGK-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1L8R9-1", "uniprot_id": "SNAPN_DANRE", "id": "Q1L8R9-1", "name": "SNARE-associated protein Snapin", "aln": "-MAAL---------AVVETPSGKDALAEGLLDLLRPAVQQLDLHVHSVRESQVELREHIDNLASELCRINEHQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHNVAKETARRKTMLEASGAFTPRSPSKP", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQF9-1", "uniprot_id": "SNAPN_DROME", "id": "Q9VQF9-1", "name": "SNAPIN protein homolog", "aln": "MDSDSTVTSLEENTENFCTNPTRDILAEGITNLFKPTIERLDERVASTIQLQAELRGQLDALAAQLRDIEKAQSQIPEFADKVKELLNVKHKVTVISNVLVTSQERLTGLHKLIEKEQRRRQALLDS--ALSTNIS---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . :* :***: ::::*::::** :* :. : *.*** ::* **::* *:: *. :: **:***.:::*.::.*:* .:**** *:: : ** **:::*:: .. . ", "identical_positions": 36, "similar_positions": 51, "identity": "25.9%" }, { "cls_id": "homologset.agr.HGNC:17146", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4V8C5-1", "uniprot_id": "AR2BP_RAT", "id": "Q4V8C5-1", "name": "ADP-ribosylation factor-like protein 2-binding protein", "aln": "---MDALEEESFALSFSSASDAEFDAVVGCLEDIIMDAEFQLLQRSFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIEEQLLERIPGFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSTPASQNNLRH--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D385-1", "uniprot_id": "AR2BP_MOUSE", "id": "Q9D385-1", "name": "ADP-ribosylation factor-like protein 2-binding protein", "aln": "---MDALEEESFALSFSSASDAEFDAVVGCLEDIIMDDEFQLLQRNFMDKYYQEFEDTEENKLTYTPIFNEYISLVEKYIEEQLLERIPGFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSTPASQNNLRH--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2Y0-1", "uniprot_id": "AR2BP_HUMAN", "id": "Q9Y2Y0-1", "name": "ADP-ribosylation factor-like protein 2-binding protein", "aln": "---MDALEGESFALSFSSASDAEFDAVVGYLEDIIMDDEFQLLQRNFMDKYYLEFEDTEENKLIYTPIFNEYISLVEKYIEEQLLQRIPEFNMAAFTTTLQHHKDEVAGDIFDMLLTFTDFLAFKEMFLDYRAEKEGRGLDLSSGLVVTSLCKSSSLPASQNNLRH--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7SYL1-1", "uniprot_id": "AR2BP_DANRE", "id": "Q7SYL1-1", "name": "ADP-ribosylation factor-like protein 2-binding protein", "aln": "MVDMQSLDEEDFSVSKSSDADAEFDIVIGNIEDIIMEDEFQHLQQSFMEKYYLEFDDSEENKLSYTPIFNEYIEILEKHLEQQLVERIPGFNMDAFTHSLKQHKDEVSGDILDMLLTFTDFMAFKEMFTDYRAEKEGRGLDLSTGLVVKSLNSSSASPLTPSMASQSI", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *::*: *.*::* ** :***** *:* :*****: *** **:.**:*** **:*:***** *********.::**::*:**::*** *** *** :*::*****:***:*********:****** **************:****.** .**: * : . : ", "identical_positions": 107, "similar_positions": 36, "identity": "63.69%" }, { "cls_id": "homologset.agr.HGNC:17147", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1WC33-1", "uniprot_id": "B1WC33_RAT", "id": "B1WC33-1", "name": "", "aln": "MPILKQLVSGSVNSKRRSRADLTAEMISAPLGDFRHTMHVGRGGDAFGDTSFLTSKTGEPDGESLDEQATSS--KLSLLSRKFRGSKRSQSVTRGDREQRDMLGSLRDSSLFVKNAMSLPQLNEKEATEKDSSKLPKSLSSSPVKKADTRDGSPK-------SPHRNGATGPHSPDPLLDEQAFGDLMDLPVMPKVSYGLKHAESILSFHIDLGPSMLGDVLSIMDKDQWGSEEEGEEEGGIYRVKEGPGGIVQGPPMLEASP-RGRQESKASWDHASMLPHHALEDDGWAAVAPSPSSARSVGSHTTRDSSSLSSYTSGVLEERSP--AFRG-PDRVGAAPPR-QPDKEFSFMDEEEEDE-IRV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JM96-1", "uniprot_id": "BORG4_MOUSE", "id": "Q9JM96-1", "name": "Cdc42 effector protein 4", "aln": "MPILKQLVSSSVNSKRRSRADLTAEMISAPLGDFRHTMHVGRAGDAFGDTSFLTSKAREADDESLDEQASAS--KLSLLSRKFRGSKRSQSVTRGDREQRDMLGSLRDSALFVKNAMSLPQLNEKEAAEKDSSKLPKSLSSSPVKKADARDGGPK-------SPHRNGATGPHSPDPLLDEQAFGDLMDLPIMPKVSYGLKHAESILSFHIDLGPSMLGDVLSIMDKDQWGSEEE--EEAGGYRDKEGPSSIVQAPPVLEVVPPLGRQESKASWDQASMLPPHAVEDDGWAVVAPSPSSARSVGSHTTRDSSSLSSYTSGVLEERSP--AFRG-PDRVAAAPPR-QPDKEFCFMDEEEEDE-IRV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3Q1-1", "uniprot_id": "BORG4_HUMAN", "id": "Q9H3Q1-1", "name": "Cdc42 effector protein 4", "aln": "MPILKQLVSSSVHSKRRSRADLTAEMISAPLGDFRHTMHVGRAGDAFGDTSFLNSKAGEPDGESLDEQPSSSSSKRSLLSRKFRGSKRSQSVTRGEREQRDMLGSLRDSALFVKNAMSLPQLNEKEAAEKGTSKLPKSLSSSPVKKANDGEGGDEEAGTEEAVPRRNGAAGPHSPDPLLDEQAFGDLTDLPVVPKATYGLKHAESIMSFHIDLGPSMLGDVLSIMDKEEWDPEEG---EGGYHGDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPS-LPSHALEDEGWAAAAPSPGSARSMGSHTTRDSSSLSSCTSGILEERSP--AFRG-PDRARAAVSR-QPDKEFSFMDEEEEDE-IRV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F7G6-1", "uniprot_id": "E7F7G6_DANRE", "id": "E7F7G6-1", "name": "", "aln": "MPILKQLVSSSSQSKRRSRADLTAEMISAPLGDFRHTMHVGRGGDAFGDTSFLSTRSGEPPKE-PEVQQSSP--KQSLLSRTFRSSKRSQSVNR-DKPEKSKLAPPSGSPSYVKNAISLPYLNDEDSGRGTGMHLPKSVSSSPLKKLPETDVKTFD------GKPLNGAAALAVSDLELDEKNFGELTDLRPSAPYTGGMKHAESIMSFHIDLGPSMLGDILSVMEKKGFDDDDLGFEEGKSS---EGRGSPPQSPP----------NEVEEEDPLPPTRPPRQK-----PGTNPYTPELQTR-NHQHLDSCSVSSSGSTVLDEKPHNLIYDGNMDNIKYSAPRVQDDTDFSYMDEDDEDEEIRV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********.* :*****************************.**********.::: *. * : * ::. * *****.**.*******.* :: ::. *.. .*. :****:*** **:::: . :****:****:** : ***:. .* ***: **:* ** . : *:******:*************:**:*:*. :. :: *. . . *.** :* : .. * : . . * . . :: .* **.*:** * :*:*:. : * *. : .* * *.:*.:***::*** ***", "identical_positions": 156, "similar_positions": 84, "identity": "42.74%" }, { "cls_id": "homologset.agr.HGNC:17148", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q811Q1-1", "uniprot_id": "SMUG1_RAT", "id": "Q811Q1-1", "name": "Single-strand selective monofunctional uracil-DNA glycosylase", "aln": "---MAVSQT---FPPG--PAHEPASALMEP--CARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAARERLQELGLLPLLTDEGSVRPTP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P5C5-1", "uniprot_id": "SMUG1_MOUSE", "id": "Q6P5C5-1", "name": "Single-strand selective monofunctional uracil DNA glycosylase", "aln": "---MAASQT---FPLG--PTHEPASALMEPLPCTRSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGVGGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSAQANKGWEAAARERLQELGLLPLLTDEGSARPT-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q53HV7-1", "uniprot_id": "SMUG1_HUMAN", "id": "Q53HV7-1", "name": "Single-strand selective monofunctional uracil DNA glycosylase", "aln": "-----MPQA---FLLG--SIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0G2KZ26-1", "uniprot_id": "A0A0G2KZ26_DANRE", "id": "A0A0G2KZ26-1", "name": "", "aln": "MLAQLDTER---LESGDASKREVPDLAVERLFNSSTAASRFLQAELELNARLQMLSFGNPVRYTYNPLEYAWETHQCYVENYCQEGQSVLFLGMNPGPFGMAQTGVPFGEVKAVRNWLKITGRVGRPADEHPKRRITGLDCTQSEVSGARFWGFFQELCGEPNNFFRHCFVHNLCPLIFMSESGKNLTPPELPAAERDALLSCCDSALCRVVTALGISMVIGVGKLSEQRARRALSEAGISVRVEGIMHPSPRNPLANKGWASVARDKLDQLGVLGLLTR--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VEM1-1", "uniprot_id": "Q9VEM1_DROME", "id": "Q9VEM1-1", "name": "", "aln": "MLKRKLNQQKCNLEIG-EPTKTSARQGSTSEFFDKPLWLKFYETEVKLNEALEKLNPPESTPFIYNPIVYASQLHCDYLRRYMDGPKKLVFVGMNPGPNGMAQTGIPFGNVRTVKLLMQLAGSVDQPPVVHPKRPVAGLDCRIEEPSGVRLWELFLRLAGSMQTFSQQCFVHNFCPLAFFGADGRNITPSEIRGAYKNQLGDLCLHTLEEQLKLLQPDVIVAVGEYVHSALKRSGYAKSNCVSVLRLPHPSPRS-TNNTNWPEKAQAFLEEHNLIRFMRNEA------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * . : . . * : *:.** *. *. :.. ***: ** : * *: .* : :.::*:****** ******:***:* *: : : * * *. **** : **:* .* **.*:* :* *.*. : * ::*****:*** *:. .*:*:**.:: . :: * . * :* . : * :::.**. .. :*: * * : *****. *..* *: *:: .:: :: ", "identical_positions": 83, "similar_positions": 78, "identity": "28.82%" }, { "cls_id": "homologset.agr.HGNC:17149", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z109-1", "uniprot_id": "VSIG2_MOUSE", "id": "Q9Z109-1", "name": "V-set and immunoglobulin domain-containing protein 2", "aln": "MAWPLVGAFLCGHLLGFVCLSGLAVEVTVPTEPLSVPKGKTAELSCSYKTSVGDNFALEWSFVQPGKPISASVPVLYFTNGHLYPTGSKADRAILLHDPPTGGLATLKLTDLRPSDTGTYLCNVNNPPDFYTNGLGLINLTVLVPPSHPLCSQSGQTSVGGSAALGCRSSEGAPKPVYNWERLGSSPTPPPGSMVQDEVSGQLILTNLSLTSSGTYRCVASNQMGSASCELNLSVTDSSEGRVAGTLIGVLLGVLLLSVAAFCLIRFQKERKKEPKETYGGSDLREDATAPGVFEQASMRADHSKELLEKSPCASTMTTTKSKLSMVV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ADY0-1", "uniprot_id": "D4ADY0_RAT", "id": "D4ADY0-1", "name": "V-set and immunoglobulin domain-containing protein 2", "aln": "MAWPLVGAFLCGHLLGFLCLSGLAVEVTVPAEPVSMPMGKTAELSCSYSTSVGDNFALEWSFVQPGKPISASAPILYFTNGHLYPTGSKADRASLLHNPPTGGLATLKLTDLRPSDTGTYLCNVNNPPDFYTNGLGLINLTVLVPPSHPLCSQSGQTSVGGSAALRCSSSEGAPKPVYNWVRLGSSPTPPPGSMVQDEVSGRLILTNLSLTSSGTYRCVASNQMGSASCELNLSVTDSSEGRVAGTLIGVLLGVLLLSVAAFCLIRFQKDRKKEPKETYGGSDLREDATAPGVSEQASVRADCSKGLLEKSPAASTVTTTKSKLSMVV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96IQ7-1", "uniprot_id": "VSIG2_HUMAN", "id": "Q96IQ7-1", "name": "V-set and immunoglobulin domain-containing protein 2", "aln": "-MAELPGPFLCGALLGFLCLSGLAVEVKVPTEPLSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPISESHPILYFTNGHLYPTGSKSKRVSLLQNPPTVGVATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLINLTVLVPPSNPLCSQSGQTSVGGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQLILTNLSLTSSGTYRCVATNQMGSASCELTLSVTEPSQGRVAGALIGVLLGVLLLSVAAFCLVRFQKERGKKPKETYGGSDLREDAIAPGISEHTCMRADSSKGFLERPSSASTVTTTKSKLPMVV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * *.**** ****:*********.**:**:* * ******:*:*.*****.*************** * *:**************:.*. **::*** *:*******::*********:************************:**************:** * ************ ***: ***.***********:******************:**********.****:.*:*****:******************:****:* *:************** ***: *::.:*** ** :**:...***:*******.***", "identical_positions": 262, "similar_positions": 45, "identity": "79.88%" }, { "cls_id": "homologset.agr.HGNC:17150", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Y2V2-1", "uniprot_id": "CHSP1_HUMAN", "id": "Q9Y2V2-1", "name": "Calcium-regulated heat-stable protein 1", "aln": "MSSEPPPPP-QPPTHQASVGLLDTPRSRERSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKH---ETWSGHVISS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9WU49-1", "uniprot_id": "CHSP1_RAT", "id": "Q9WU49-1", "name": "Calcium-regulated heat stable protein 1", "aln": "MSSEPPPPP-QPPTHQTSIGLLDTPRARDRSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKH---ETWSGHVISS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CR86-1", "uniprot_id": "CHSP1_MOUSE", "id": "Q9CR86-1", "name": "Calcium-regulated heat stable protein 1", "aln": "MSSEPPPPPLQPPTHQTSVGLLDTPRTRDRSPSPLRGNVVPSPLPTRRTRTFSATVRASQGPVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEKLQAVEVVITHLAPGTKH---ETWSGHVISN-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VVA0-1", "uniprot_id": "Y9705_DROME", "id": "Q9VVA0-1", "name": "Cold shock domain-containing protein CG9705", "aln": "-MTEP-----RTPEKLLAA---KPPVLHHNSHSPNASLQLPSPIITRRTRTASTSARALENPVVTGMVKSFSRTKGHGFITPNAGGEDVFCHVSDIEGEYVPMPGDEVKYRLCAIPPKYEKHQAVHVQISHLTPEVHHKWEEPFYGGSSPAK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :** :.* : : ..* :..* ** . :***: ****** *::.** :.** .*: *.*.*:******** ** *:* *:**:******: ****.*::*:**** ** ***.* *:**:* .:* *.: * . ", "identical_positions": 69, "similar_positions": 39, "identity": "45.39%" }, { "cls_id": "homologset.agr.HGNC:17151", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7FAH8-1", "uniprot_id": "F7FAH8_RAT", "id": "F7FAH8-1", "name": "Origin recognition complex subunit 6", "aln": "MESDLVRHLARRLGLGE-PSVLRKAEEYLRLSKVKCVSLSAHTSETSNAVICLDLAASCRKCPLDRAYLIKLSGLNKKMYQSCLKSFECLLGLNSNIGLRDLAVQFSCTEAVNLAAGILQSYESSLPEAQRADLDLSRPLFTTAALLSACKILKIKVDKTKMITTSGVKKTIFDRLCTQLEKIGQQINRDSADLASPALKKKKPAFSPALKKKKSGLEQPAKDIEVIETS-DKLPKDAGLTQDYEEWKRKILENAAKAQTAAVE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WUJ8-1", "uniprot_id": "ORC6_MOUSE", "id": "Q9WUJ8-1", "name": "Origin recognition complex subunit 6", "aln": "MESELVRRLAPRLGLAE-PSVLRKAEEFLRLSKVKCVSLSARSSETSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMMYQSCLKSFECLLGLNSNVGIRDLAVQFSCTEAVNLAAEILQSYKSGLPETQRADLDLSRPLFTTAALLSACKILKIKVDKTKMITTSGVKKAILDRLCKQLEKIGQQINRDSADLARPALKRKKPEFSPTLKKKEPGLEPPAKEIEVIETL-HKLPKDEDLTQDYEEWKRKILENAAKAQTATAE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y5N6-1", "uniprot_id": "ORC6_HUMAN", "id": "Q9Y5N6-1", "name": "Origin recognition complex subunit 6", "aln": "MGSELIGRLAPRLGLAE-PDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKK-----------IVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9Y1B2-1", "uniprot_id": "ORC6_DROME", "id": "Q9Y1B2-1", "name": "Origin recognition complex subunit 6", "aln": "-MTTLIEQLITKMGLREEPNVLEKTTELVRLLELRSTNVPLQINEYGKIVLCADLASCMIGIAFDKEQALKLSGLRKSQYLNNKRMFEKLLDLNKLASVNDICVQLGLNEVARKAEELMTLFKG-VAATEDMGTDTSHPQYATMAVFQACRLLKKKVSKSKLMPFSNLRPSQFQLLEQQWERMIAKHHKESKVPSSTDMEGKLKE-----NQNENIKGHEAKKAHKPPPEDYEIWKARMLAKAQAKLKELEASQSHMDSQLLEA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *: :* ::** * *.:*.*: * :** .::...:. : .* .. *:* ***:. .:*: ::****.* * . : ** **.**. .:.*:.**:. *... * :: ::. :. :: . * *:* ::: *::.**::** **.*.*::. *.:: : :: * * *:: : .::. : . : * **. . : * *:: : *. .:: . ", "identical_positions": 57, "similar_positions": 96, "identity": "21.59%" }, { "cls_id": "homologset.agr.HGNC:17152", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R0X4-1", "uniprot_id": "ACOT9_MOUSE", "id": "Q9R0X4-1", "name": "Acyl-coenzyme A thioesterase 9, mitochondrial", "aln": "--------------------------------MKRAAIRLWTLNKGLLTHGRGLSQGSQY-KISEP--LHIHQVRDKLREIVGVSTVWRDHVKAMEERKLLHSFLPKSQKVLPPRKMRDSYIEVLLPLGTDPELRDKYVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTKM---SPLSIVTVLVDKIDMC-KHSLSPEQDIKFTGHVSWVGNTSMEVKMKMFQ------LHNDEKYWPVLDATFVMVARDSENKGPAFVNPLIPENKEEEELFKQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLTT-LDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQDNYIQVRVHSEVSSLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q32MW3-1", "uniprot_id": "ACO10_MOUSE", "id": "Q32MW3-1", "name": "Acyl-coenzyme A thioesterase 10, mitochondrial", "aln": "--------------------------------MKRAAMRLWTLNKGLLTHGRGLSQGSQY-KISEP--LHIHQVQVKLREIVGISTVWRDHVQAMEERKLLHSFLPKSQKVLPPRKIRDSYIEVLLPLGTDPELRDKYVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTNM---SLLSIVTVLVDKIDMC-KHSLSPEQDIKFTGHVSWVGNTTMEVKMKMFQ------LHDDETYWPVLDATFVMVAQDSENKRPAFVNPLIPENKEEEELFTQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLST-LDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQGNYIQVRVHSEVFSLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7ETS0-1", "uniprot_id": "F7ETS0_RAT", "id": "F7ETS0-1", "name": "", "aln": "--------------------------------MKRAAMRLWTLNKGLLTHGRGLAYGSEN-KICKP--LHIQEVRNKLREIVGVSTIWRDHVKAMEERKLLHNFLATSQKALPPRKMKDSYIEVLLPLGSDPDLRDKYLTVQNTVRFGRILEDLDSLGVLVCYMHNQNHSTKM---SPLSIVTVLVDKIDMC-KYSLSPEQDIKFTGHVSWVGKTSMEVKMKMFQSSYSFHMHSDDKFWPVLDATFVMVARDSENKGPAFVNPLVPENKEEEELITQGELNKSRRIAFSTTSLLKVAPNSEERNVIHELFLNT-LDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQDNYIQVRVHSEVASLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVILKKNYTVEP---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y305-1", "uniprot_id": "ACOT9_HUMAN", "id": "Q9Y305-1", "name": "Acyl-coenzyme A thioesterase 9, mitochondrial", "aln": "--------------------------------MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGI--FHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKM---SPLSIVTALVDKIDMC-KKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQ------LHGDE-FCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLST-LDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB40E6M3-1", "uniprot_id": "A0AB40E6M3_DANRE", "id": "A0AB40E6M3-1", "name": "", "aln": "------------------------------MFCPRFLKAAVSFTCRKFSMGQISRQGKTLDMAE---------VRNRLREVVGASTNWQDQQQVLSERSSLCQYLARSQDDLPAKRMKDSLIEAHLPLGSQPALREKYLNSHNSVRFGRILEDLDCLGVLICYSHTWNEELQS---SPLSIVTALVDKIDMR-QNVIYPDCDIKFTGHVTWVGKTSIEAKMHMSQ-------YQNGTYADLLDATFVMVARDPDNKRAAFVNPLKPVGQEEEAIFLQGEINKKRRVELSTASLLKVAPTAEERTLIHNQFLNT-LDTRTVSFRSRILPPNSVWMEDAKLKGLEICHPQERNIFNRIFGGFLMRKAYELGRANACAFAGCRPTVVAVDDILFRKPVEIGSLLLLSSQVCYTEGMYVQVRVHSEVLDPLTRQHSTTNVFHFTFRLEKEVPAVVPQSYGESMLYLDGKRHFDGAMRNHS------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1R961-1", "uniprot_id": "F1R961_DANRE", "id": "F1R961-1", "name": "", "aln": "------------------------------MLSPRVLKSASSLMCRGFSMGQMCRQGKAPDMADGNTFLLVSNVRNRLREIVGASTNWRDHQQALAERASLTQYLANSQDELPTKTMKDSAIEAHLPLGTQPALREKYLNYHNSVRFGRILEDLDSLAVLICYSHTWNKELQR---SPLSIVTALVDKIDMR-KNIIYPDCDIKFTGHVTWVGKTSIEAKMHMSQ-------FHDGVYSDVLDATFVMVARDPENKRAAFINPLKPEGPEEEAIFQQGEINKKRRVELSTASLLKVAPTAEERTLIHNQFLNT-LDTRTVSFRSRILPPNSVWMEDAKMKGLEICHPQERNIFNRIFGGFLMRKAYELGWANACAFAGCRPTLVAVDDILFRRPVEIGSLLLLSSQVCYTEGMHVQVRVHTEVLDPLTRQHSTTNVFHFTFRVDKDVPAVVPQSYGESMLYLDGKRHFDETMRGQS------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VMA4-1", "uniprot_id": "Q9VMA4_DROME", "id": "Q9VMA4-1", "name": "HotDog ACOT-type domain-containing protein", "aln": "----------MNLSQHFG--------------RRVIAVRHPWHQLGAIRHSFMESGRELLDSGHRS--GTMADVAKKIREHVGVEGGYHIIP---KSRDGLLKFQPK-QDELPNRSMLDSQTTAQVLLETDALLRQRFVYGRGLLRMGRIIEELDLLAVWICHLHIHLPNLPEGVPLPYTFITMLVDHAHFL-QDKFIADADVSLSGHVSYTDNNFMEVTAYVRQ-------SG----MLLAKGIFVVEARDAINNGPAPVNPLVPANELEESLHQEAQKRHQER-AKALYRLESQQPTKEEQQLMYELFTRTKGDDGPSPSDMTTLPPNSRWMSTWRRRTLMHPFPENRNESNTIFGGFIIRKAIEISYMTASLYSNQRCMIRFIADVTFAHSIPVHSYIKLKAYVVFTHENYIQLLTVVNAIDGNSFTELKCNVLHLTYSCSKAVPEILPRSYHEALWYLTGRRYFNRFRESVSHDMDNGSAVETNGAKKDN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9V9W4-1", "uniprot_id": "Q9V9W4_DROME", "id": "Q9V9W4-1", "name": "HotDog ACOT-type domain-containing protein", "aln": "--------MLCTLARSFGTALARRSSWSTARRRRLLATSPPPLASQQMPRSYTLDNGPKVKSDHRS--GTMVEVARVIREQSGVDVGYHTIP---KPRDHLLQHEPK-REELPPRTMLDSHTTAILPLSSSELIRESYVNHLGRVRLGRIMEELDMFAVWICHRHVKLPKLPKGVPLPYTFVTLLVDKVEFTNLERLQVNQDIEISGHISWAGRSSMEITIYVRQ-------LAHGEYIDVTKAIFVMVARNATNTGPAPINPIEVGDETEKLIWEQAEKRQKVRKSSAMDSVFNSPPREHEQALMYEILKRTTPAN-SMDLNKRVLPPKCRWMEDSMQSTMIAPFPENRNAQNTIFGGYLMRQAVEISFIMASIYLGDRPTLRCISDISFMHPVHVDRFLQLTAHVVYAAQNYVQLMTVAQIWDAKSGKVQTTNVFYLTYRADKVLDEVLPRSYREMLWYVHGRRKLLGALHLQPEYPDPIEVAKESSNHIST", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9V9W5-1", "uniprot_id": "Q9V9W5_DROME", "id": "Q9V9W5-1", "name": "HotDog ACOT-type domain-containing protein", "aln": "MGPGLRNVKLCVVPFLLG--------------ARSCRSLLKARTLRKMTHKNSSSNGRNSSADGQY--ATMTEIKKKMLKSFGLEPGFTTEP---KSREDLLKYQPK-FEDLPARSMQDSFCSAIIPLSTNAVLQDKYINFRGFARLGRLLEDMDIFAAWCCNRHLKVPNLPEGVPLPYSLVTVLVDRIDFT-SVSPQGTQDIRLSGHVSWVGTSSMEVVVWLEQ-------IVNEEYQKITRALFLMAARNATNTAAAPVNPIQPANEEEKRILAGGTDRKKQRQLLIAQSVFKVEPNAEEQSLIYKLYKRTTPNEQTGPR--RLLPPNCIWMHDSFQMSTIPSFPEHRNQNNTVFGGFLMRSALEISWATAFLYCKARPTLEHISDISFQKPVSVNSFIKMTAYVVYTQENYLQIMTVAEVLDAYTGNHVTTNTFHYTFSAPDAVTEVLPRSYHETMWYIHGRRKFIASRS---------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : * . : * * .. . . ** : : ** . : * :. ::: :: . *:**::*::* :.. * * . :::* ***: .: *: ::**:::.. . :* : * : . *:: *::. *. .* :**: . *: : . .: * : . * .*: ::: * . **.:. ** .*:.** * :***:::*.* *:. * : * : : *: * :.: : : :.: * :: ::*: . : . . *.:: *: . : :.*::* * : *: *:* : ", "identical_positions": 63, "similar_positions": 121, "identity": "12.75%" }, { "cls_id": "homologset.agr.HGNC:17153", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BG26-1", "uniprot_id": "RUSC1_MOUSE", "id": "Q8BG26-1", "name": "AP-4 complex accessory subunit RUSC1", "aln": "MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELREGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGSSIENQQDPSQEEE-AVSPSDPGCSSSLSSCSDLSPDESPVSVYSRDLPGNEDANPQPS--TLELGSPLAPAGPSTCSPDSFCCSPDSCSGISSPPGPDLDSNCNALTTCQDLPSPGLEEEEDSGEQDLATSELSETEDGRIDAGKAEPSWKINPIWKIDTEKTEAGWKTIEDSDSGRKTDENTNSSLKTESGKLASCLNTN-----SGSKIDAGKTDGGWRGDVSQEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPTGSLGGSLAPPREVTTFKELRSRSRAQPPPVPPRDPPAGWALVPPRPPPPPVPPRRKKNRLGLQPIAEGLSEEGRAASPRAGEEASASQEPEEPRAHAVVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSASVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSCTHSMGSLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGSCPSLATELLLLLQPLSVLTFHLDLLFEHHHHLPVGLQQAPAPSCPPPALQQTMQAVLHWGERLAQSLRGTSGESTTDSSTPSARPPAGSWWDQLTQASRVYASGGTEGFPLLRWGPRRHGTTAEA-AQEAPPPTEQTTPGRSVWLGRLFGVPGCPSETESGAFKSRRPSSWLPPTVSVLALVKRGTPPETP-PEALVSSPGSVVQADRAVRALCDHTAAGPDQLSFQRGELLRVIATVDEDWLRCGRDGVEGLVPVGYTSLVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BVN2-1", "uniprot_id": "RUSC1_HUMAN", "id": "Q9BVN2-1", "name": "AP-4 complex accessory subunit RUSC1", "aln": "MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQEEEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLPGDEDAHPQPSIIPLEQGSPLASAGPGTCSPDSFCCSPDSCSGASSSPDPGLDSNCNALTTCQDVPSPGLEEEDERAEQDLPTSELLEADDGKIDAGKTEPSWKINPIWKIDTEKTKAEWKTTENNNTGWKNNGNVNSSWKSEPEKFDSGWKTNTRITDSGSKTDAGKIDGGWRSDVSEEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPSGSPGGSSAPPREVTTFKELRSRSRAPAPPVPPRDPPVGWALVPPRPPPPPVPPRRKKNRPGLQPIAEGQSEEGRAVSPAAGEEAPAAKEPG-AQAGLEVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P05369-1", "uniprot_id": "FPPS_RAT", "id": "P05369-1", "name": "Farnesyl pyrophosphate synthase", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGDQKLDVHNQEK--------------------QNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSYTRRGQICWYQ------KPGIGLDAINDALLLEAAIYRLLKFYCREQ-----------------PYYLNLLELFLQSSYQTEIG---------QTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYS------------FYLPIAAAMYMAG-------------IDGEKEHANALKILLEMGEFFQIQDDYLD-LFGDPSVTGKVGTDIQDNK--CSWL-----VVQCLLRATPQQRQILEENYGQKDPEKVAR--VKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK-", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * *:* : : :. :::*.**. ::: : :**... . : :: . :: . **. .:. : *.. . :: ::. * ... : ::: :. : * :* .: : : :.:::: * : :* *:. : . *:*::: :: :* . * : *. :. * : :. :: * *. *: :* :* .* . * : : :. :*. *** *. ..: .. ..: .*** *: : *.:* : : .. : *:** :. . :.:.... *: : ::: . . *. *. ", "identical_positions": 47, "similar_positions": 135, "identity": "5.2%" }, { "cls_id": "homologset.agr.HGNC:17155", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AWA9-1", "uniprot_id": "RBGP1_MOUSE", "id": "A2AWA9-1", "name": "Rab GTPase-activating protein 1", "aln": "MDD----KASVGKISVS------SDS-VSTLNSEDFVLVSRQGDE--------------TPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDD------------QPG-----ERSQLDGEGDGPLSNQL----------------SASST-----------INPVPLVGLPKPEMSLPVKPGQGDSEVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTP------------DSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVICVQQTAN---KELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKS-----------------YVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNER--LFWPFSKRSTTENFFLKLKQIKQKEKKNNADTLYEVVCLESESERER--RKTTASPSVRLPQSGSQSSMIPSPPEDDEEEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLSVRPKQLSSLVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKR---LMELACNTKISQKKLKKFEKEYHTMREQQAQQEDPIERFER---ENRRLQEANMRLEQENDDLAHELVTSK--------IALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFFNKEGRVKG-------------------ISSAKGVSDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLG--LALSEVQAAKKTWFNRTLSSIKT--ATGVQGKETC------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZX42-1", "uniprot_id": "D3ZX42_RAT", "id": "D3ZX42-1", "name": "Rab GTPase-activating protein 1", "aln": "MDD----KASVGKISVS------SDS-VSTLNSEDFVLVSRQGDE--------------TPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDD------------QPGM----ERSHLDGEGDGPLSNQL----------------SASST-----------INPVPLVGLQKPEMSLPVKSGQGDSEVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNVSEGTVRLLDPQINTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTP------------DSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVICVQQTAN---KELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKS-----------------YVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNER--LFWPFSKRSTTENFFLKLKQIKQKEKKNNADTLYEVVCLESESERER--RKTTASPSVRLPQSGSQSSMIPSPPEDDEEEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKR---LMELACNTKISQKKLKKFEKEYHTMREQQAQQEDPIERFER---ENRRLQEANMRLEQENDDLAHELVTSK--------IALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFFNKEGRVKG-------------------ASSVKGVSDEDTDEEKETLKNQLRELELELAQTKLQLVEAECKIQDLEHHLG--LALSEVQAAKKTWFNRTLSSIKT--ATGVQGKETC------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y3P9-1", "uniprot_id": "RBGP1_HUMAN", "id": "Q9Y3P9-1", "name": "Rab GTPase-activating protein 1", "aln": "MDD----KASVGKISVS------SDS-VSTLNSEDFVLVSRQGDE--------------TPSTNNGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMDD------------QPGEKELVKRSQLDGEGDGPLSNQL----------------SASST-----------INPVPLVGLQKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTP------------DSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTN---KELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKS-----------------YVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQEPVRFLLETKVRVCSPNER--LFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESESERER--RKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKK---LMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFER---ENRRLQEANMRLEQENDDLAHELVTSK--------IALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKG-------------------ISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLG--LALNEVQAAKKTWFNRTLSSIKT--ATGVQGKETC------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8JNN5-1", "uniprot_id": "A8JNN5_DROME", "id": "A8JNN5-1", "name": "", "aln": "MDDNLSTKSSESSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALSSPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTTDEEVS-----EIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHG-DALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPR--DRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSS-DGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDS--EKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED-AFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARK---VMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRDNGSGGPMPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASVGGSPKLPSKFQATKLRNSIDSLRNIVVPLDTGKTLAENLKQQLQQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04322-1", "uniprot_id": "GYL1_YEAST", "id": "Q04322-1", "name": "Probable GTPase-activating protein GYL1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNSNEDIHEERIEVPRTPHQTQPEKDSDRIALRDEISVPEGDEKAYSDEKVEMATTNASSNFGSNESAKDG--------------------------------ESIGAFSNPHEALMQSKLREESQSKTILPSDD---------------LSQQLETEESKVEEALKRITSPPLPPRADCIEESASALKSSLPPVLAGNKN--DQAPLDRPQ---LPPRQVVNAETLHLKAPHGNATPS------------------------------KSPTSAVGNSSS--------STPPTLPPRRIEDPLDLAAQKHFLASTFKRN-MLFYKSEDNSIKCDLDKNILNLKEDSKKINNNEIPEEVS----------------------------------------------------------------SFWLKVIGDYQNILINDIETLHFQLSRGIPAAYRLVVWQLVSYAK-SKSFDPIYETYLTEMAP------FDVQEFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLRLLFLPSASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSS-------------------EYEEIHRLDNEKEVQYKSITEKN-------LHLQKHVRKLENDYTSLNREHVTIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKKKQVLGVYVPNDLKKDLEETMKKN-------TQVMDENLKLQDRISELERLIEEIKT--------------------ANKNGTLFEYSNSKNNPLGAGWSGFKKVFK----------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .:: : *. .. .. :.* :*:*: .* . : * *. : . * *::. . . :: . . * . . : * : . :: * *:: . *. * . . ::* :.* : * . :** .. . . :. * .: :.. : .:::*: : :. . : .. : .... . : :: . :: . * * * : . * :: .:. : * : *:* * * :** :: . : *. :*: : *::. . :.: .. . : :: *** :.* * :. . ::: :* ** ** :** :* **** *: . . : *:::**::: *.:::*: .:.: *: . :* **: ::* : :: *:.: :*: ::.: **. ....* .*:. *: :: * . ...:. : ::. * *: ..: : :: . :: ::: : ..* :: : . *:. :*.. : : . . . : . * : :: : : : . : .. : : : : . : :: . .:: :. : :. .: : ", "identical_positions": 78, "similar_positions": 250, "identity": "6.43%" }, { "cls_id": "homologset.agr.HGNC:17156", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JHF9-1", "uniprot_id": "LY96_MOUSE", "id": "Q9JHF9-1", "name": "Lymphocyte antigen 96", "aln": "MLPFILFSTLLSPILTESEKQQWFCNSSDAIISYSYCDHLKFPISISSEPCIRLRGTNGFVHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDDDYSFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAGDTEEKLFCLNFTIIHRRDVN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6A532-1", "uniprot_id": "A0A8I6A532_RAT", "id": "A0A8I6A532-1", "name": "Lymphocyte antigen 96", "aln": "-MQIKRGNSWMG-TSKSHDWQQWICNSSDAIISYSYCDHMKIPISISSEPCIRLKGTNGFVHVEFIPRGNLKNLYFNLFININSIELPKRKEIVCHGYDDDYSFCRALKGEAVNTAIPFSFDGILFPKGHHRCVAEAIAGDTEEKLFCLNFTIIHHHNVN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Y6Y9-1", "uniprot_id": "LY96_HUMAN", "id": "Q9Y6Y9-1", "name": "Lymphocyte antigen 96", "aln": "MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .: :. .. : * *.****** ***:***::: ****. :***.*: ::*::*: :*** :** *****:*.:*:::******::*:* *************:***:*.***.** *.**:::**.***:*..** ****:*.*:*: : *", "identical_positions": 85, "similar_positions": 51, "identity": "53.12%" }, { "cls_id": "homologset.agr.HGNC:17157", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3ZAV8-1", "uniprot_id": "EDC4_RAT", "id": "Q3ZAV8-1", "name": "Enhancer of mRNA-decapping protein 4", "aln": "MASCASIDIEDATQHLRDILKLDRP---AGGSNVESQRPSSAYNG-------DLNGLLVPDPLSSGDGNSTSKPGIRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYY-GNLIAVSN--SFLAYAIRA---ANNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGDLFVWRLALVKGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDC----CEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQN----------QDEGRACFS-----SISEFLLTHPVLSFGIQVVSRCRLR-HTEVLPAEEESDSLGTESSHGAGTLESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLSTHTAHEDFTFGESRPELGSEGLAS----APHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPTASLQQISASPSSSSSSSSSSSSSSSSSSSSSLTAVSAVSSSSAMDPSLPSRPPEELTLSPKLQLDGSLTISSSSS-LQASPRSLLPGLLPGPADKLIPKGPGQVSSGTSALSLDLQEVEPLGLPQASPSRTRSPDVISSASTALSQDIPEIASEALSRGFG--SSVPEGLIEPDSMASAASALHLLSPRPRQGPE---LSSQLGLDGGPGDGDRHSTPSLLEAALTQEVATSD---------SQVWPTAPDITRETCSTLTES-----PRNGLQEKHKSLAFHRPPYHLLQQHDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPAKDWKTKGSPRTSPKLKRKSKKDDGDSAVGSRLTEHQVVEPPEDWPALIWQQQRELAELWHNQEELLQR--LCAQLEGLQSTVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPVAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLDSHMKSRKAREQEAREPVLAQLRGLVSTLQNATEQMAATVSSSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQATVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQADPHNSLGKAARRLSLMLHGLVTPSLP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UJB9-1", "uniprot_id": "EDC4_MOUSE", "id": "Q3UJB9-1", "name": "Enhancer of mRNA-decapping protein 4", "aln": "MASCASIDIEDATQHLRDILKLDRP---AGGSNAESQRPSSAYNG-------DLNGLLVPDPLSSGDGNSTNKPGIRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYY-GNLIAVSN--SFLAYAIRA---ANNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVKGKIQEEILVHIRQPEGTALNHFRRIIWCPFIPEESEDC----CEESSPTVALLHEDRAEVWDLDMLRSSHNTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQN----------QDEGRACFS-----SISEFLLTHPVLSFGIQVVSRCRLR-HTEVLPAEEENDSLGTESSHGAGALESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLSTHTAHEDFTFGESRPELGSEGLAS----AAHGSQPDLRRIVELPAPADFLSLSSETKPELMTPDAFMTPTASLQQISASPSSSSSSSSSSSSSSSSSSSS-LTAVSAVSSSSAMDPSLP-RPPEELTLSPKLQLDGSLTLNSSSSSLQASPRSLLPGLLPGPADKLISKGPGQVSTAASALSLDLQEVEPLGLPQASPSRTRSPDVISSASTALSQDIPEIASEALSRGFG--SSVPEGLIEPNSMASAASALHLLSPRPRQGPE---LGSQLGLDGGPGDGDRHSTPSLLEAALTQEVATPD---------SQVWPTAPDITRETCSTLTES-----PRNGLQEKHKSLAFHRPPYHLLQQRDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPSKDWKTKGSPRTSPKLKRKSKKDDGDSAVGSRLTEHQVAEPPEDWPALIWQQQRELAELWHNQEELLQR--LCAQLEGLQSTVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSVRDEIKKTVPPCVSRSLEPVAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVSSSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQATVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQADPHNSLSKAARRLSLMLHGLVTPSLP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6P2E9-1", "uniprot_id": "EDC4_HUMAN", "id": "Q6P2E9-1", "name": "Enhancer of mRNA-decapping protein 4", "aln": "MASCASIDIEDATQHLRDILKLDRP---AGGPSAESPRPSSAYNG-------DLNGLLVPDPLCSGDSTSANKTGLRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYY-GNLIAVSN--SFLAYAIRA---ANNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDC----CEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQN----------QEEGHACFS-----SISEFLLTHPVLSFGIQVVSRCRLR-HTEVLPAEEENDSLGADGTHGAGAMESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGS----AAHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSASLQQITASPSSSSSGSSSSSSSSSSS----LTAVSAMSSTSAVDPSLT-RPPEELTLSPKLQLDGSLTMSSSGS-LQASPRGLLPGLLPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDVISSASTALSQDIPEIASEALSRGFG--SSAPEG-LEPDSMASAASALHLLSPRPRPGPE---LGPQLGLDGGPGDGDRHNTPSLLEAALTQEASTPD---------SQVWPTAPDITRETCSTLAES-----PRNGLQEKHKSLAFHRPPYHLLQQRDSQDASAEQSDHDDEVASLASASGGFGTKVPAPRLPAKDWKTKGSPRTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSQEELLQR--LCTQLEGLQSTVTGHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVAGSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRTDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPHNSLGKAARRLSLMLHGLVTPSLP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1LUT1-1", "uniprot_id": "EDC4_DANRE", "id": "Q1LUT1-1", "name": "Enhancer of mRNA-decapping protein 4", "aln": "MASSSSMDIEGATQHLRDILKLDRPGNSAEASLVESQR-KPSFNG-------ELNGVLGSDLMG----AAMVEPTVHNSDKLNGQDTQTICLSGDDGSICVPIRANIVEIVSSRDSSIDSKARGSNKVKIQPVAKYDWEHKYYY-GNLIAVSN--TYLAYAIRG---ANN-HSMIRVLHLSSTERSLLKGFTGAVTDLAFAHLDSTLLGCVDEAGNMFIWQLTSHSSKIQDEVIVHIRRPEDTPLNSNRRLIWCPFIPEDNDES----PEDACQTLALLHEDRAEVWDLDILRSNNSSWPVDATELKEGFITIRGHAARISEGALSPDGTVLATASHDGYVKFWQIYIEGQDQPRCLHEWQPHNGQPLSCLLFCDNHKKQDPDVPFWRFLITGADQNQELKMWCTVSWTCLQTIRFSPDPFN-CGVLPSLKASLDLSAEFLILSDVQRKVLYVMELLQD----------QEKGRASFT-----AVSEFLLTHPVLSFGVQDVSRARLR-HTEVLPPEEESESMTAEGNQ--GTSESRSGIQIKLYCVHTKSLQDVQIWFQPNQGDSSSLFMPQSGSQDGFSFSDPLADLNVEAMSSDKESGDSGSQNDLSKILPLPSPADFMSPAPSALPKLMTPDAFMTPSASMP---ASPGSSASS---------------LTIVTAMSSSDSGA-----RGGDDLTQSPKMSVECVNSSFANAG-SPRSNSILISGLGEN----------IQVSPPNPPLSLDLQAIDPMVVPQASPTRARSPDVISSASTAMSQDIPEIASETLQRGLSGANADSGPILHSDSMASAASILHLLSPRARSSAEHSLLPLELGAASVDGEQRLSNTPSLLETALSQENAGAAGGSCSDSSVNHAWPAAPDITRETRNSLRDNGLGDCSREEIKDRHISSPYHRRTYHLTQN-DSQDASAEQSDHDDEVASLASSSGNCGPRS-SHRLPVKDWKT--SPRSSPKLKRKSKKDEGESSQSRQIESQMSTEVQDELLQMLRSQQREIAELRQNQLDLLQR--VTSHMDAVQSSMMAHIEHAMLAQQEQEQRRMERILVEGQSRNQQLQDQLVQQLVQTLNNSLCNRLEKVLREEMKKTVPQTISKSLEPVTGQMNSTIAAKLTAVEGALKENVTKVVKSKNTTDAIGRAAAEAMQGPIQAAYKETFQSIVLPVFERGCQSMFQQINDSFKQGTNEYIQQLETHIKNRKQRDQDTRDPVIGQLQQMIDSLQSSQDQLASTVTASVSSDVQHQLHMIVGNLQDSILTQVQRIVKGEVSLAMKEQQAAVTSSIMQAMRSAAGTPVPSAHLDYQAQQASILQLLQQGQLNEAFQQALSAADLNLVLYVCETIDSQQVFGQQPCPLHQAVLLSLIQQLSTNLSTRTELKISYLEDAVMNLDHGDPVTRDHMSAVLTQVRQKLFLFLQQDAHSPMSKRARRLMMMLQGLVNH---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VKK1-1", "uniprot_id": "EDC4_DROME", "id": "Q9VKK1-1", "name": "Enhancer of mRNA-decapping protein 4 homolog", "aln": "-MLIALFALAHLPIFRKTPLSASSSPPPSVHRSPRCGKASTAYHPPPADACISITASAIDAASGMSNSAEQDKPIAANGNAAEPQEIEVIHFQAQEKQCCRVIRSNKTKVLTSG----GVHTRGSSKVKLKNIVDYKWERKYYYPGHLVAVHRDGKHLAYAINVNNKATGMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHTDCERILAVIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYVCSSSATVPINDDDDENQLLIWSRSSQFQCFQVKMIVSEHGRGKIQPAALESGYLKIE-EDSLITCAALSPDGTTVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHDGKKVCSLFFLDNINKP-VEESYWQHVITTSDANTEIKLWNCSLWKCLQTINVVASPSS--LQPRNFIAGIDRSANYLVLSCLDSLAVYVMQIGSTGGADSENRSSDSEGEGCDTSKRIQNVAEFKLSSGILSFSIVNASMRRVKNSIESYYPIEEPDDFDD-------DSNSTSALVLHMFVVQAKSLQECQIIYQPCVAEKTERSSLNSKRSQ---TPEDNLLIKEEPESP-----NSGTVGAVQLDALFAKSAKRASTGSSSAMVAVAAAAAAAPSAILQDATKEAAKSESP----------------------QLSSAYTQQVNLMTPDAFSASGTAAAAAVFVSTSTTTSIGTDSS---------------------TTTSGQDRSIDSAVLQTIRMLATVTSKTSEN---PNAEVLLNLMNNTLIEDREQQKLKEKLDARKKFIAIDRNPERNVAENLASGSSSPSRE----VQEIMATQDDADAYEAELENLDDDDDDEEEELAN---------SSPLPEAVDGTWPIVKLSSHS----------AELQNAAQIMSQAVQNTNNGNVPPTLGGGHNNNTSVGSNSNNNTATTLSTSNTSSSNNAGGTCVDSSGTGELNAKMELLIDLVKAQSKQINKLENEVN-----KLQKQQEAAAALHSKQDTSLEPKNLSQLAYKIEMQLSKLMEQYLKRYENEHKKKLTEFLAARESQNRELRDSVLQVLNQYVMNHFTDIIGNVLNMELQRQLLPRVNANMDQLQAQMQVEIVQKLSVFDKTVKENIAQVCKSKQFLDTFGKSVLIGVQTSLQTAFIESMSSTLIPAYEKSSQNMFKQLHDAFSVGIKDFMVQFNTYLQHMPQPQAGSGN--TEEINNKLSMLKQLVESSLHKHR-TELTDAMLETQREVKSLEILLARQVQETIRAELRKHMEAQN--------VAMRSQAATPAPPYDLR-----DSIKQLLMAGQINKAFHQALLANDLGLVEFTLRHTDSNQAFAPEGCRLEQKVLLSLIQQISADMTNHNELKQRYLNEALLAINMADPITREHAPKVLTELYRNCQQFIKNSPKNSQFSNVRLLMKAIITYRDQLK-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : . . : *. . . : .. : ..::: .:.. :. . : *: :.* :..:: . * * :: .::::* . ::***.***:: :..*.**:**** *:*:** . ..*****. *.. .*:** :::: *:*:**::* * ** *** :. : .: :...:*:::: ..:: ::::::. * . : : ***:: ... :: : :..: : :::.:: *.:. :: : ::.*:: :. . : :: .*******.:*:*. ** *:*:***: . : ******:**:*: :..*:* ** :* : .:*:.:** :* * *:*:* *.*****.. .. . .: . :* **::*:** :: .:***:: . :.:*... : ::** *: :***.: .* *:: * . ** :.: :* :.: :::: *::*:**: ** :** . : : : * .. *: : :. .*. * ...: ::. * :*:* : ....* * . :.: : :: * . :. . ... *:: ::.: : : .::: . ..*.. :. : .: .: : : : .. :* * . . * :: .: . .* : :* . . * * * * . .. : : : . : :: : : . ::: .*.* :. . . : * .. : :*: * : . : .: * : .**. * * .* *: : :: : :*: : .::.:::: . *. :.:. :*::.: * * * : . . . : . :. *::: : :. .:: : .*:. :. **:..: ::***:::: ***: *::.::. :* .:*:*: *::.* ::*.:*:..* **:*::*:* * :::: *:::::: : : : ::. :. *:. :. . : ::. : : * .*: : ***. ::.*: :: *: **** *.**.*. .* * *** *::*:**:*** * **.** :. . *. *.*. * * * ********::::: .:.:** **::*:: :: .**:**:* *:::: :: *:: ..:.. . .* * : ", "identical_positions": 250, "similar_positions": 509, "identity": "17.02%" }, { "cls_id": "homologset.agr.HGNC:17158", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5FVH2-1", "uniprot_id": "PLD3_RAT", "id": "Q5FVH2-1", "name": "5'-3' exonuclease PLD3", "aln": "MKPKLMYQELKVPVEEP---AGELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQHP-APCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTH-TQEPSAQQGEEVLQQLQALAPRG-----VKVRIAVSKPNGP--LADLQSLLQSG-AQVRMVDMQKLT-HGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRPFDTRYNQETPMEICLNG-TPALAYLASAPPPLCPGGRTPDLKALLSVVDNARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSEPSMRSFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERTTYIGTSNWSGSYFTETAGTSLLVTQNGHGG----LRSQLEAVFLRDWESPYSHNLDTSADSVGNACRLL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35405-1", "uniprot_id": "PLD3_MOUSE", "id": "O35405-1", "name": "5'-3' exonuclease PLD3", "aln": "MKPKLMYQELKVPVEEP---AGELPLNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRP-APCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTH-TQEPSAQQGEEVLQQLQALAPRG-----VKVRIAVSKPNGP--LADLQSLLQSG-AQVRMVDMQKLT-HGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRSFDTRYNQETPMEICLNG-TPALAYLASAPPPLCPSGRTPDLKALLNVVDSARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSDPSMRSFLLSLAALHDNHTHSDIQVKLFVVPTDESQARIPYARVNHNKYMVTERASYIGTSNWSGSYFTETAGTSLLVTQNGHGG----LRSQLEAVFLRDWESPYSHDLDTSANSVGNACRLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IV08-1", "uniprot_id": "PLD3_HUMAN", "id": "Q8IV08-1", "name": "5'-3' exonuclease PLD3", "aln": "MKPKLMYQELKVPAEEP---ANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRP-APCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTH-TQEPSAQQGEEVLRQLQTLAPKG-----VNVRIAVSKPSGPQPQADLQALLQSG-AQVRMVDMQKLT-HGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNG-TPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGG----LRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1L8A0-1", "uniprot_id": "Q1L8A0_DANRE", "id": "Q1L8A0-1", "name": "5'-3' exonuclease PLD3", "aln": "MKSDIPYEKM-VDVELS---RGEGHHGSQKYYRCLIVLT--CITTVLLILLSLQTLLVPMAKSSSTKSSVQQERVLIRETCTDPCRIVLVESIPEGMVFN--SSVHQSIYDAWLNLISATQSSLDIASFYWTLTNSDTH-TQEPTANQGQQILKKLGQLSSK------AYVRIAVDKPADKKPMEDINFLSSYG-ADVRMVNMRELT-TGVLHTKFWIVDKKHIYIGSANMDWRSLTQVKELGAVVYDCSCLAEDLGKIFEAYWYLNQT-KTVPAHWPNKYSTLYNKDTPMQLSLNG-TSASVYLSSSPPSLCAEGRTPDLQSILDVIANAQQFVYIAVMNYLPTMEFSRSKRYWMDIDTELRRVAYERRIRVRLLISCWNSTKPIMFPFLRSLASLQDTN-QLDIQVRIFTVPSDAQQKKIPFARVNHNKYMVTDQVAYIGTSNWSGDYFVNTAGSALVVNQTSASASS-TVQEQLQAVFERDWESAYSTDINHRSNRK-DIC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VIF2-1", "uniprot_id": "Q9VIF2_DROME", "id": "Q9VIF2-1", "name": "", "aln": "MPEYKKLEDQESDVENANRTTVQNTATVQDAGEGQRQAAGQQAGQMVTVSLFMLLFLGSSYFQPRPRLHQYKGGRGHGLLEKFDCNIQLVESIPIGLTYPDGSPRFLSTYEAWLELLESATTSLDIASFYWTLKAEDTPGVSDNSTRPGEDVFARLLANGNGGSRSPRIKIRIAQSEPSSGTPNLNTKLLASAGAAEVVSISFPKYFGSGVLHTKLWVVDNKHFYLGSANMDWRALTQVKEMGVLVQNCPELTHDVAKIFGEYWYLGNSESSRIPDWDWRYATSYNLKHPMQLSVNKNTSIEGFLSSSPPPLSPSGRTDDLNAILNTINTAITYVNIAVMDYYPLIIYEKNHHYWPFIDDALRKAAVERGVAVKLLISWWKHSNPSEDRYLRSLQDLASKEDKIDIQIRRFIVPTDSSQEKIPFGRVNHNKYMVTDRVAYIGTSNWSGDYFTDTAGIGLVLSETFETETTNTLRSDLRNVFERDWNSKYATPLV-------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :. .* . : . . : :: : : :: *. ****** *: : :. * :*** *: .: :***********. .** ..: ::. *:::: :* . :*** .:* . : : * . * *:* :.: : ******:*:**:.*:*:********:******:*.:: :*. *:.*: *** **:*.:: .: . * : * ** . **::.:* *. :*:*:**.*.. *** **:::*..: .* :: :***:* * : :.: :::* ** **:.: ** : *:**** * :.* :* ** * ... : ***:: * **:* * :**:.**********::.:*********.**.:*** .*::.:. ::.:*. :* ***:* *: : ", "identical_positions": 158, "similar_positions": 144, "identity": "31.16%" }, { "cls_id": "homologset.agr.HGNC:17160", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AY65-1", "uniprot_id": "ARFP2_RAT", "id": "Q6AY65-1", "name": "Arfaptin-2", "aln": "MTDGILGKAATMEIPIHGN---GEAGQLPEDDG--LEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGP--------GDEVARG----IAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K221-1", "uniprot_id": "ARFP2_MOUSE", "id": "Q8K221-1", "name": "Arfaptin-2", "aln": "MTDGILGKAATMEIPIHGN---GEAGQLPEDDG--LEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGP--------GDEVARG----IAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P53365-1", "uniprot_id": "ARFP2_HUMAN", "id": "P53365-1", "name": "Arfaptin-2", "aln": "MTDGILGKAATMEIPIHGN---GEARQLPEDDG--LEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGP--------GDEVARG----IAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B3N8-1", "uniprot_id": "A0A8M2B3N8_DANRE", "id": "A0A8M2B3N8-1", "name": "", "aln": "MTDSLLSKAATMEIPINSN---GDSR-SAEDDS--LEQDLQQVMVSGPNLNETSIVSGGYGGAAEGIIPTSSIKAPGMHHSNSNPS-----LMSEEATKG----VAVEKFDTVKKWSINTYKCTKQMFSERFGRGTKTVDLELEAQIDVLRETKLKYERILRLARELTNHFYNMVQTQQALGDTFADLSQKSPELQDEFGYNAETQRLLCKNGETLLGAINFFVSSINTLVNKTMEDTLMTIKTYENARLEFDAYRSDLEELSAGPRDAATMMRIEIAQQQYQIQKDKYERLHSDVTIKLKFLEENKVKVMHKQLLLFHNAISAYFAGNQQQLEQTLRQFNVKLKPPGSDKPSWLEEQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9Q652-1", "uniprot_id": "A0A8M9Q652_DANRE", "id": "A0A8M9Q652-1", "name": "", "aln": "MADSMMSKAATMEIPISSN---GDSRNLAEDDS--LEQDLQQVMVSGPNLNETSIVSGGYGGTTEGIIPTSSIKGSNMDYVGSNSS-----MAAEEATRG----VAVEKFDIMKKWGLNTYKCTKQMISERFGRGSRTVDLELEAQIEVLRETKRKYENVLRLARALTNHFYSMVQTQHALGDTFADLSQKSPELRDEFGYNAETQKLLCKNGETLLGAINFFVSSINTLVNKTMEDTLMTIKMYENARLEFDAYRADLEELNMGPRDAVTMARIEAAQQQYQIHKDKYERLRSDVTIKIKFLEENKVKVMHKQLLLFHNAISAYFAGNQQQLEQTLKQFNIKLKPPGADKPSWLEEQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VGQ8-1", "uniprot_id": "Q9VGQ8_DROME", "id": "Q9VGQ8-1", "name": "", "aln": "MTDRERSIHEMLKDAPSLNDSCGAVHTGTEGGSGILGSASSHSIAGGGGGGGNVGVGVGGPFGAPSSLPLRNHSAPTTPMSPSSPPSGNGILSPTDSGSGSIIRTSASKIDSLKNWSISTYKCTRQIMLEKLGKSQRTVDSELEAQIEQLRETQRKYLSILRLTRAFSSHFQHVVVTQHALADSFADLAQKNPELQKEFTCNSETQRNLTKNGELLLNALNFFISSVNTLCNKTIDDTLLTIRQYETARIEFDAYRMDLENT--KPELTPSAVALEETQRSYAQHKEQYEKLRSDVAVKMQFLDENRIKVMHKQLILLHNAIAAYFSGNAMALESTLKQFNIKLKSPNAVTGSWLEQ-", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:* . :: . * * .*... * . .: :..* . . . *. * . :* . . *.. : * : .*:* :*:*.:.*****:*:: *::*:. :*** *** **: ****: ** :*:* * :: *: :: **:**.*:****:**.***:.** *:***: * **** **.*:***:**:*** .**::***:*:: ** **:*:**** ***: *. : : :* :* : ::::**:*:.**::*::**:**::*******:*:***::***:** **.**:***:**:.*.: . ****: ", "identical_positions": 139, "similar_positions": 107, "identity": "38.83%" }, { "cls_id": "homologset.agr.HGNC:17162", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Y4Y9-1", "uniprot_id": "LSM5_HUMAN", "id": "Q9Y4Y9-1", "name": "U6 snRNA-associated Sm-like protein LSm5", "aln": "MAAN-ATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEF-EITPEGRR----ITKLDQILLNGNNITMLVPGGEGPEV---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P62322-1", "uniprot_id": "LSM5_MOUSE", "id": "P62322-1", "name": "U6 snRNA-associated Sm-like protein LSm5", "aln": "MAAN-ATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEF-EITPEGRR----ITKLDQILLNGNNITMLVPGGEGPEV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZBJ0-1", "uniprot_id": "D3ZBJ0_RAT", "id": "D3ZBJ0-1", "name": "U6 snRNA-associated Sm-like protein LSm5", "aln": "MAAN-ATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVSILFISVCLFSEITPEGRR----ITKLDQILLNGNNITMLVPGGEGPEV---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VRT7-1", "uniprot_id": "Q9VRT7_DROME", "id": "Q9VRT7-1", "name": "U6 snRNA-associated Sm-like protein LSm5", "aln": "MTAVPPPSNISTLMPLELVDKCIGSRIHIIMKNDKEMVGTLLGFDDFVNMLLDDVTEY-ENTPDGRR----ITKLDQILLNGNNITMLVPGGELAE----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40089-1", "uniprot_id": "LSM5_YEAST", "id": "P40089-1", "name": "LSM complex subunit LSM5", "aln": "-------MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . ::***::** *..:: *:::.::*: ***:******.::: .. : . : * : : .::**.****::*****: . ", "identical_positions": 29, "similar_positions": 37, "identity": "29.0%" }, { "cls_id": "homologset.agr.HGNC:17163", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q675A5-1", "uniprot_id": "PAG15_RAT", "id": "Q675A5-1", "name": "Lysosomal phospholipase A and acyltransferase", "aln": "----------------------------------------------------------------------MDRHLCICREIQLRSGLLFPFLLLMMLA------DLALPAQR-------------------HPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRTTQFP----------------------------DGVDVRVPGFGETFSLEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGP---YFLALQEMIEEMYQMYG-GPVVLVAHSMGNMYMLYFLQRQPQA----------WKDKYIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIR--------EQQRSAVSTSWLLPYNHTWSHEKVFVYTPTAN----------------YTLRDYHRFFQDIGFEDG----------WFMRQDTQGLVEALV--------------------------PPGVELHCLYGTGVPTPNSFYYEN-----------FPDRDPKICFGDGDGTVNLESVLQCQAWQS---------------RQEHKVSLQELPG----SEHIEMLANATTLAYLKRVLLEEP----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VEB4-1", "uniprot_id": "PAG15_MOUSE", "id": "Q8VEB4-1", "name": "Lysosomal phospholipase A and acyltransferase", "aln": "----------------------------------------------------------------------MDRHLCTCRETQLRSGLLLPLFLLMMLA------DLTLPAQR-------------------HPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKKTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFP----------------------------DGVDVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGP---YFLALREMIEEMYQMYG-GPVVLVAHSMGNVYMLYFLQRQPQV----------WKDKYIHAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIR--------EQQRSAVSTSWLLPYNHTWSHEKVFVYTPTTN----------------YTLRDYHRFFRDIGFEDG----------WFMRQDTEGLVEAMT--------------------------PPGVELHCLYGTGVPTPNSFYYES-----------FPDRDPKICFGDGDGTVNLESVLQCQAWQS---------------RQEHRVSLQELPG----SEHIEMLANATTLAYLKRVLLEP-----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NCC3-1", "uniprot_id": "PAG15_HUMAN", "id": "Q8NCC3-1", "name": "Lysosomal phospholipase A and acyltransferase", "aln": "----------------------------------------------------------------------MGLHLRPYRVGLLPDGLLFLLLLLMLLA------DPALPAGR-------------------HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFP----------------------------DGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGP---YFLALREMIEEMYQLYG-GPVVLVAHSMGNMYTLYFLQRQPQA----------WKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIR--------EQQRSAVSTSWLLPYNYTWSPEKVFVQTPTIN----------------YTLRDYRKFFQDIGFEDG----------WLMRQDTEGLVEATM--------------------------PPGVQLHCLYGTGVPTPDSFYYES-----------FPDRDPKICFGDGDGTVNLKSALQCQAWQS---------------RQEHQVLLQELPG----SEHIEMLANATTLAYLKRVLLGP-----------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB13A862-1", "uniprot_id": "A0AB13A862_DANRE", "id": "A0AB13A862-1", "name": "", "aln": "-------------------------------------------------------------------------MLPSHRLILASLQLCLLLLVVSFTE------GRSLKCPPGKVC-------------SVRPPVVLIPGDLGNQLEAKLDKPSVVHYICYKKTEDYFTLWLNLELLVPVAIDCWIDNMRLLYNRTNHLSEPP----------------------------PGVDIRVPGFGETYSLEYLDPSKRSVGMYFFTIVQSLVDWGYTRNDDVRGAPYDWRKAPNENKE---YFLRLQQMIEEMAHKAG-GPVVLIAHSMGNMYTLYFLNHQPQA----------WKDRYIKAYVSLGPPWAGVAKTLRVMATGDNNRIPVISPLKIR--------TQQRTAVSTTWLLPYAHTWPKDMVLVYTPNTT----------------YTVQDYQRFFKDIDYEDG----------WAMRQDTEPLVSALQ--------------------------PPGVPVHCLYGTGIPTPQGYNYTN-----------FPDTDPAVINGDGDGTVNLISAIQCKRWKG---------------QQKQAVEWLELPG----NEHVAMLLNSTTVDYIKKVLFSP-----------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9I7L9-1", "uniprot_id": "Q9I7L9_DROME", "id": "Q9I7L9-1", "name": "Group XV phospholipase A2", "aln": "----------------------------------------------------------------------MRLKSGVLSLLLLTTFLALGECFWPFSKWHGRNDNPSAPPEPK------------------LSPVIFVPGDGGSQMDARLNKPNSPYLIC-QKTHDWYNLWLDLEQLVIPMVYCWIDNVKLYYDKVTRTTHNT----------------------------PGVETRIPGWGNPEVVEWIDPTKNSAGAYFKDIANELVKLGYIRKQNIHGAPYDFRKAPNENQQ---FFIDLKQLVEDSYEANNQSAVTFISHSMGSLMTLVFLQEQTLQ----------WKAKYVKRMISLAGVWAGSFKAVKVFAMGDDLDSFALSAKILK--------AEQITHPSTAWLLPSPLFWKPSEVLAMTPSRN----------------YTMAQLEEFFKDLDYMTG----------WEMRKDTIRYNRNFD--------------------------PPNVELHCLYGEGIDTVERLQYKKSD---------ISGETPKLIMGLGDGTVNQRSLRACKYWAG---------------YSKAPINTLALQN----VDHLHILSNPDVLKYIRTVMQQP-----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40345-1", "uniprot_id": "PDAT_YEAST", "id": "P40345-1", "name": "Phospholipid:diacylglycerol acyltransferase", "aln": "MGTLFRRNVQNQKSDSDENNKGGSVHNKRESRNHIHHQQGLGHKRRRGISGSAKRNERGKDFDRKRDGNGRKRWRDSRRLIFILGAFLGVLLPFSFGAYHVHNSDSDLFDNFVNFDSLKVYLDDWKDVLPQGISSFIDDIQAGNYSTSSLDDLSENFAVGKQLLRDYNIEAKHPVVMVPGVISTGIESWGVIGDDECDSSAHFRKRLWGSFYMLRTMVMDKVCWLKHVMLDPETGLDPPNFTLRAAQGFESTDYFIAGYWIWNKVFQNLGVIGYEPNKMTSAAYDWRLAYLDLERRDRYFTKLKEQIELFHQLSG-EKVCLIGHSMGSQIIFYFMKWVEAEGPLYGNGGRGWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAMYGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSEDALNNNTDTYGNFIRFERNTSDAFNKNLTMKDAINMTLSISPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHWSNPMEVPLPEAPHMKIYCIYGVNNPTERAYVYKEEDDSSALNLTIDYESKQPVFLTEGDGTVPLVAHSMCHKWAQGASPYNPAGINVTIVEMKHQPDRFDIRGGAKSAEHVDILGSAELNDYILKIASGNGDLVEPRQLSNLSQWVSQMPFPM", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . . .: : *. : *:. . . : : .: . :: : *:. : : : . *.: : .. .* :: . . : . :.: .*.**:* * : :* *:: :* . . * ::.****. : *:: * .:: :. . * *:: .: *: :.. : :: . .* :* . : . . : * ::: . * *: .* : ::*:** . * * . : ***** : *: * : : . :*: :* .. *: : ", "identical_positions": 44, "similar_positions": 109, "identity": "6.65%" }, { "cls_id": "homologset.agr.HGNC:17164", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P59017-1", "uniprot_id": "B2L13_MOUSE", "id": "P59017-1", "name": "Bcl-2-like protein 13", "aln": "MASS---TTASLGFHYETKYVVLSYLGLLSQEKQQGP---SPPGVQLDVAPQSLNPEVLLKLKSEIEEELKTLDKEVSEAFTSTGFDCHTSPVFSPANPESSIEDCLAHLGERVSQDLKEPLQKALQTILSQPVTYEAYRECTVETAVHASGWNKLLVPLVLLQHLLLELTRRGQEPLRMLLQFGVMYLEEHAAEFIIQQGGWGSVFSLEPEEEEYPGIIAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSSGAGEKSENNSSNSDIVHVEKEEVPE------------------EAFPGAAAPLLTQVPTVEAP-------EMMRAEKTSPTPSVFVELGEEELEAVTARPEAVERAE-----GAAQLSEERAGSRKKSHTGEAAAVRGAKSGLPAEG------------------KAVLLFGGAAAVAILAVAVGVALALRRK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZT71-1", "uniprot_id": "D3ZT71_RAT", "id": "D3ZT71-1", "name": "", "aln": "MASSSSSTTVPLGFHYETKYVVLSYLGLLSQEKQQGP---SPQGSQLDVAPQSLNPEVLLKIKSEIEEELKSLDKEVSEAFTSTGFDCHTSPVFSPANPESSVEDCLAQLGERVSRDLSEPLQKALQMILSQPVTYEAYRECTVETAVHASGWNKILVPLVLLQQMLLELARRGQEPLSTLLQFGVMYLEEHGAEFIIQQGGWGTVFSLESEEEEFPGIIAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSSGAGEKSENNSSNSDIVHVEKEEVPE------------------EAFPGATGPLLPQVTPMEAS-------EMMRVEKTSPTPSVFVELGEEDLEVVTVRPDAVE--------GAAQLSEERSGRRRKSHTGEAIAARGTKSGLPAEG------------------KAVLLFGGAAAVALLAVAVGVALALRKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXK5-1", "uniprot_id": "B2L13_HUMAN", "id": "Q9BXK5-1", "name": "Bcl-2-like protein 13", "aln": "MASS---STVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQLDIASQSLDQEILLKVKTEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMEDCLAHLGEKVSQELKEPLHKALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQEPLSALLQFGVTYLEDYSAEYIIQQGGWGTVFSLESEEEEYPGITAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSNGAGEKSENNSSNSDIVHVEKEEVPEGMEEAAVASVVLPARELQEALPEAPAPLLPHITATSLLGTREPDTEVITVEKSSPATSLFVELDEEEVKAATTEPTEVEEVVPALEPTETLLSEKEINAREESLVEELSPASEKKPVPPSEGKSRLSPAGEMKPMPLSEGKSILLFGGAAAVAILAVAIGVALALRKK", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**** :*..********************** * ** * ***:*.***: *:***:*:*******:****:********** **************:*****:***:**::*.***:**** :*******:*:****:**:********:*******:::****:******* ****** ***::.**:********:*****.****:*** **************************************************************************.************************* **:* *..***.::.. . *:: .**:**:.*:****.**:::..*..* ** : ***:. . *.:* . * .. *. *:** *::**********:****:*******:*", "identical_positions": 322, "similar_positions": 76, "identity": "65.98%" }, { "cls_id": "homologset.agr.HGNC:17165", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U2Y6-1", "uniprot_id": "TFP11_RAT", "id": "Q5U2Y6-1", "name": "Tuftelin-interacting protein 11", "aln": "MSLSHLYRDGEGHLDDDDD-ERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDE-------ERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSEDSDAEEKPVKQ-------EDFPKDLGPKKLKTGGN-------------------FKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQS---LQDFPVADSEEEAEEEFQKELSQWRKDPSG-----SKKKPKYSYKTVEELKAKG-RVSKKLTAPQ-KELSQVKVIDMTGREQKVYYSYSQISHKHSVPDEGVPLLAQLPPTAGKEAKVPGFALPELEHNLQLLIERTEQEIIQSDRQLQYERDMVVSLSHELEKTAEVLAHEERVISNLSKVLALVEECEHRMQPHGADPLTLDECAR--IFETLQDKYYEEYRLADRADLAVAIVYPLVKDYFKDWHPLEDSNYGTQIISKWKSLLENDQLLSHSSQDLSSDAFHRLMWEVWMPFVRNVVAQWQPRNCEPMVDFLDSWAHIIPVWILDNILDQLIFPKLQKEVDNWNPLTDTVPIHSWIHPWLPLMQARLEP-LYSPVRSKLSSALQKWHPSDASAKLILQPWKEVLTPGSWEAFMLRNIVPKLGMCLGELVINPHQQHMDAFYWVMDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQR--GIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGE--KTWVPTSLQSLIDMAK----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ERA6-1", "uniprot_id": "TFP11_MOUSE", "id": "Q9ERA6-1", "name": "Tuftelin-interacting protein 11", "aln": "MSLSHLYRDGEGHLDDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDE-------ERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSEDSDAEEKPVKQ-------EDFPKDLGPKKLKTGGN-------------------FKPSQKGFSGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQS---LQDFPVADSEEEAEEEFQKELSQWRKDPSG-----SKKKPKYSYKTVEELKAKG-RVSKKLTAPQ-KELSQVKVIDMTGREQKVYYSYSQISHKHSVPDEGVPLLAQLPPTAGKEARMPGFALPELEHNLQLLIERTEQEIIQSDRQLQYERDMVVSLSHELEKTAEVLAHEERVISNLSKVLALVEECERRMQPHGADPLTLDECAR--IFETLQDKYYEEYRLADRADLAVAIVYPLVKDYFKDWHPLEDGSYGTQIISKWKSLLENDQLLSHSSQDLSSDAFHRLMWEVWMPFVRNVVAQWQPRNCEPMVDFLDSWAHIIPVWILDNILDQLIFPKLQKEVDNWNPLTDTVPIHSWIHPWLPLMQARLEP-LYSPVRSKLSSALQKWHPSDASAKLILQPWKEVLTPGSWEAFMLRNIVPKLGMCLGELVINPHQQHMDAFYWVMDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQR--GIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGE--KTWVPTSLQSLIDMAK----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UBB9-1", "uniprot_id": "TFP11_HUMAN", "id": "Q9UBB9-1", "name": "Tuftelin-interacting protein 11", "aln": "MSLSHLYRDGEGRIDDDDD-ERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDD-------ERPSFGGKRARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKPVKQ-------DDFPKDFGPRKLKTGGN-------------------FKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQS---MQDFPVVDSEEEAEEEFQKELSQWRKDPSG-----SKKKPKYSYKTVEELKAKG-RISKKLTAPQ-KELSQVKVIDMTGREQKVYYSYSQISHKHNVPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQEIIQNDRQLQYERDMVVNLFHELEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCSNPLTLDECAR--IFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADAFHRLIWEVWMPFVRNIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQARLEP-LYSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQR--GIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGE--KTWVPTSLQSLIDMAK----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DI35-1", "uniprot_id": "TFP11_DANRE", "id": "Q6DI35-1", "name": "Tuftelin-interacting protein 11", "aln": "MSMSHLYG-RRGDEEEEDGVEIEKFEVSEWDLANEFNPDRRRYRQTKEEATYGIWAEQDSDD-------ERPSFGGKRAKDYSTPVSFVSAGLRKTAAEEKAEREGSDDSDAEEA-------PPPPRAAAPKKLQTGGS-------------------FKTSQR-FAGGIRTGQDLGNWEKHTRGIGQKLLQKMGYVPGKGLGKNAQGIVNPIEAKLRKGKGAVGAYGSERTQQS---LQDFPVVDSEEEEEEEFQKELGQWRKEPGT-----AKKKPKYSYRTVDDLKAHGTRANMSMSRPA-GELAQVKVIDMTGREQKVYNSYSHMSQKHSVPEEAP------LSVSTREQKSSGFALPELEHNLKLLIELTEQDILQSARLLQHEKDTVVTLTHESDALQVRLAEEEETLGRLEQVMSLVERFEAGDK-EGDPALSLQECAK--IFEQLQTEFYQEYKTMGLGDLAVSVVHPLLKEKLRNWDPLKDCSDGLEEVGQWRAILESTLSLHSGPDTTNMDPYHRLIWEVWVPVMRTCVSQWQPRNVGPMVDCVECWAPVLPLWILDHVLEQLIFPRLQREVDNWNPLTDTVPIHSWIHPWLPLMQTRLEP-LYAPIRSKLAHALQRWHPSDSSARLILQPWRDVFTPGAWEAFMVKNIVPKLALCLGELVVNPHQQLLDPFNWVMDWECMLSVSSMVGLLDKNFFPKWLQVLCSWLSNNPNYEEITKWYLGWKGLLSENLLSHPLVKEKLNEALDIMNRAVASGLGGYMQPGARENIAYLIQTERRKDFQCELQPERREVDNSATRPPGMAAVPASVPTNFKDLVQAKAEENGIVFMPLVAKRHMGKQLFTFGRIVIYIERGVVFVQGE--KTWVPTSLQSLIDMAK----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9Y103-1", "uniprot_id": "TFP11_DROME", "id": "Q9Y103-1", "name": "Septin-interacting protein 1", "aln": "----------------MSDNDYERFEITDYDLDNEFNINRPRGRQSRHQQIYGIWADDSEEESGGEGGTKRRGRAARKPKDYTMPVNFVAGGIQQAGKKKKKALQADDEKGSQKEGAEADQGEESDDSAASGRPAFGQNDPGSSNSSSEEERPTLSRKQPSTTFQHRSHIASERNVGAWEQHTRGIGAKLLLQMGYEPGKGLGKDLQGISHPVQAHVRKGRGAIGAYGPETAASIGGKTNKSIKVDEDVREAKEFKDQLNKWRKGSAGGAEPMERQGKRYYYKSVEEVIAKGHTSGHLLSEKLSKKLGNVRVIDMTGPEKRVLSGYHALGQAKITPEETLY---DTEATEKGSAPACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECSSQQAALESEHRKLEEIVQLERNHIRTLEESLERVERLIDNPD------LSLPQAER--LFRELLVDYAAEFHEFGLADLAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGMLQQGDAAEQQPR-NVFDPYSSLIWAGVMPSFRSSAAAWQPKEHPPMASLLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPIDSWVLPWHAILGSKLEEAVYPQIRSKLGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIVPKLQATLGELIINPMHQDLELWQQVWEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAEISRWYTGWKSMLSEPLLREPSVKEHLRRALEIMHRASDTLLQPTVTPTPPPPVPPAPVIM-------------------------MDLIHPPAQLEFKELVSQQCADLGIIFAPLPGRREMGKQIYRVGKLFCYIDRHVCMVSDGSFSNWKPVSLNHLLERSQTGIL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06411-1", "uniprot_id": "SP382_YEAST", "id": "Q06411-1", "name": "Pre-mRNA-splicing factor SPP382", "aln": "------------------------MEDSDSNTDKKFFFKKRR------IDSYNYSDEEDNNS------------------SMNSDMTYTNDALKTSSGNAPTISKLT--------------------------------------------------------------------------KTYGIGAKLLSSMGYVAGKGLGKDGSGITTPIETQSRPMHNAGLGMFSNTNSSNYHSENEDYLSSEDEVVEGIEQVKFNKTSTEVLG-----EALLNDSGDMTIVRTLRELRLAGVQLPESILKELDPLNAVPKPKKDVVVEILQELLGIEKSLEAIRQR--TSPLEVQVKEYYGQERLLSELEVTLRDESKHVSLYDKIGAILKLSDDELIDRLTSCLLRKELLIEFDLDHLEKPNDILDELTQIIELLAYRMDTTSKFLNRTQTTIFKVIYPKLKKFWEGFDMTKSKIDSAITLLLDFQQVLSFIG-CKEHIMEEFVYPKLLQELDNWELHDEVDHVSP-RIWVLDFMVLIDDKIKDTIVDKIEAKFFAYCKNWYHRESFCITN--SDIIFIKELICERRYYK-----ILCKEFLPKFLDELWERHNDPIYELEDWKEKQEWKEKDSGFFYFMKKLRSYTHYFHPKQYELMMRG-TFNNINKILYQWHLYSTVEDLHKSKWWLNW--LMNTVFEHSLPTEIELSEIRKSYNIFAMSHRYHLDKSTLDEDFDLRQGLRNLMETQVIDDISQSEQEPTYTVQNIPLGKVSSSFKDVVEDYCLEK--------------------------GYLISKIPNRYTQLPYGRDQD---CIVPLFEIRNGKK------KMEVALKHDILWVEDSS-GTFKPIYLWALDL-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :: : ::* .: * *. : ..:. . . :.: .:: . : . :* *** *** .*** .*:****: .** *:::: * :.* . .: . :. ..: : ::.: . :: . . :. :* :..: . : * :. : . :.** .*: . . . * : : : .. : : . .: : : :*. : . :. . . .*: : . : :*:. .. : : . : : . * . : : : :.: .* :. : ..:: : : : : :* * : . * .: . : : :: . :: * : : . : :. :* ::. * . :.. : : . : : : .:. . * .. * :.: .: : : . : . : . .:.:* : : : *: *. * :: :.: : *.. .: * * * ", "identical_positions": 51, "similar_positions": 201, "identity": "5.72%" }, { "cls_id": "homologset.agr.HGNC:17166", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AB25-1", "uniprot_id": "D4AB25_RAT", "id": "D4AB25-1", "name": "", "aln": "-----------------------------------------------------------------MGRKMRG-AAAAGLWLLALGSLLTLWGGLLPPRTELPASRPPEDRLPRHPIQSGGPAPEPRFPLP------------------------------PPLVWDARGGSLKTFRALLTLAAGADNPPGRHPDDRG-------------RHVPSGLSWPAEHTAVHGGVFWSRGLEEQVPRGFSEAQAAAWLEVARGARVVALDRGGCGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWVQVQEELRTAHWTEGSVVSLTRWLPNLTDVVVPEPWR--------------------------------------------SEDGRLRPLRDAGGELTNLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMHRATSNLHRG-PGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLYSRHEPR--FPELAELADPHAQLLQRRLDFLAKHILHCKAKYGRRPGDLITLRGREGLGYE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BQB4-1", "uniprot_id": "FJX1_MOUSE", "id": "Q8BQB4-1", "name": "Four-jointed box protein 1", "aln": "-----------------------------------------------------------------MGRKMRGAAAAAGLWLLALSSLLTLWGGLLPPRTELPASRPPEDRLPPHPIQSGGPAPEPRFPLP------------------------------PPLVWDARGGSLKTFRALLTLAAGADNPPRRHQDDRG-------------RHEPSGLSWPEERRAVHGGVFWSRGLEEQVPRGFSEAQAAAWLEVARGARVVALDRGGCGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWVQVQEELRTAHWTEGSVVSLTRWLPNLTDVVVPEPWR--------------------------------------------SEDGRLRPLRDAGGELTNLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMHRATSNLHRG-PGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLYSRHEPR--FPELAELSEPHAQLLQRRLDFLAKHILHCKAKYGRRPGDLITLRGREGLGYE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86VR8-1", "uniprot_id": "FJX1_HUMAN", "id": "Q86VR8-1", "name": "Four-jointed box protein 1", "aln": "-----------------------------------------------------------------MGRRMRGAAATAGLWLLALGSLLALWGGLLPPRTELPASRPPEDRLPRRPARSGGPAPAPRFPLP------------------------------PPLAWDARGGSLKTFRALLTLAAGADGPPRQSRSEPR-------------WHVSARQPRPEESAAVHGGVFWSRGLEEQVPPGFSEAQAAAWLEAARGARMVALERGGCGRSSNRLARFADGTRACVRYGINPEQIQGEALSYYLARLLGLQRHVPPLALARVEARGAQWAQVQEELRAAHWTEGSVVSLTRWLPNLTDVVVPAPWR--------------------------------------------SEDGRLRPLRDAGGELANLSQAELVDLVQWTDLILFDYLTANFDRLVSNLFSLQWDPRVMQRATSNLHRG-PGGALVFLDNEAGLVHGYRVAGMWDKYNEPLLQSVCVFRERTARRVLELHRGQDAAARLLRLYRRHEPR--FPELAALADPHAQLLQRRLDFLAKHILHCKAKYGRRSGT-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QZU9-1", "uniprot_id": "F1QZU9_DANRE", "id": "F1QZU9-1", "name": "", "aln": "---------------------------------------------------------------------MRLVIMKAG--KVKLCASLCVWLGIVT--------------------WIGN---VKLHLLS------------------------------VFVQQDTDRGVLFSVANNQVNNTEINAPG--MRGAKS-------------FNIRSALILDN---VIEQRVFWSAWLEALATRVFGVEHERKWRERVRDARVVALEAG-CGRPTNRLASFADGTRACVRYGIDADQVLGETLSYYLAELLGIS-NLPPLSLSKLNLSSEQWASVRENIEVLEWSPNAIVSLTEFIPNVTGVFIPAHLQ--------------------------------------------KQQ------QLSAESLSNMTLSYLLELMQWGDLILFDYLTANFDRIVSHIFSLQWDARVMERTTNNLLKT-VNGDLLFIDNEAGLVHGYRVLDLWERYHKILLSSSCMFRRSTVRRVSELKRSGNSAKLLYELYRAREPL--ARELGSLSEEHALTLQSRIDVVYKHIKLCTEIM-------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P54360-1", "uniprot_id": "FOJO_DROME", "id": "P54360-1", "name": "Extracellular serine/threonine protein kinase four-jointed", "aln": "MYDIKRLEAGQQKLQQAQQPLGLDLSGQQQQLTCSVITAPEHRANPNPSSISQSNPSEATHMTLLTLRRRRSLQRRACLLSILAAFVFGMALGVVVPMFGLPRHQDSPPDLPEEQIQMVAVEPLSSYRVEFIKETDELSAEQVFRNAFHLEQDKDAPDSMVVKKLDTNDGSIKEFHVQRTASGRYRKGPERRLSKKMPERVQPQETSRSPTTSPTNPTSEHQAGFIEEDVYWGPTVEQALPKGFAAKDQVSWERFVGEQGRVVRLEQGCGRMQNRMVVFADGTRACARYRQNTDQIQGEIFSYYLGQLLNIS-NLAPSAATVVDTSTPNWAAALGDITQAQWKERRPVVLTRWLSDLEPAGIPQPFQPLERHLNKHDVWNLTRHMQSERQAQSQPHGLLKRLGAASSPGSAHQSNAIEETGTGTETANGALVQRLIELAQWSDLIVFDYLIANLDRVVNNLYNFQWNADIMAAPAHNLARQSASQLLVFLDNESGLLHGYRLLKKYEAYHSLLLDNLCVFRRPTIDALRRLRAAG-AGRRLRDLFERTTSAGVRDVLPSLPDKSVKILVERIDRVLGQVQKCQGS--------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * : : : *:: . : *: * : . . . : :. *:*. :* . *. . * . . *. *** **:. ********.** :.:*: ** :****..**.:. ::.* : : :: :*. . :: .*. * **.::.:: . :* : :. . . *::* ** ***:**** **:**:*.:::.:**:. :* .: ** : . *:*:***:**:****: :: *:. **.. *:**. * : .*: . :. * *: . * *.: . * *:* : :: * ", "identical_positions": 90, "similar_positions": 110, "identity": "14.88%" }, { "cls_id": "homologset.agr.HGNC:17167", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C6N3-1", "uniprot_id": "SYT15_MOUSE", "id": "Q8C6N3-1", "name": "Synaptotagmin-15", "aln": "MAEQLAFLIGGIIGG--LLLLIGVSCCLWRRFCATFTYEELPETSDPATISYFSRKEDRLYQ-YSGTPPGRLPSVPFVVPPSHQGRDWVPLHGGDWAVAPQDPCPVPEHMACTSSAKPGD----ACEMGSINPELYKSPEDTSETGFPDGCLGRLWFSVEYQQESERLLVGLIKAQQLQVPSETCSTLVKLHLLPDERRFLQSKTKHKICNPQFDENFIFQVSSKSVTQRVLKFSVYHVNKKRKHQLLGQVLFPLKNETLAGDHHRIIWRDLEAKNLEPPSEFGDIQFCLSYNDYLSRLTVVVLRAKGLQLQEDRSVVSVFVKVSLMNHNKFVKCKRTSAVLGSVNPVYNETFSFKVDTNELDTASLSLVVLQTTEGNKSSPLGRVVVGPYMYTRGKELEHWGEMLRKPKELVKRWHALCRPTEP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P59926-1", "uniprot_id": "SYT15_RAT", "id": "P59926-1", "name": "Synaptotagmin-15", "aln": "MAEQLALVIGCIIGG--LLLLIGISCCLWKRLCTTFTYEELPETADTATSSSFSKKEERPCR-YAGIPSVRLPSVPFVVPPSHQGRDWVRLHGGDWAVAPQDPCPVPEHITCTSSPAAGQTSLPLCVMGSINPELYKSSEDVSEAGFPDGCLGRLWFSVEYQQESERLLVDLIKAQHLQVPAETCSTLVKLHLLPDKRRFLQSKAKRKTCNPQFDESFIFQVSSKSVAQRVLKFSVYHINKQRKHQLLGQVLFPLKNETLAGDRHRVIWRDLEAENLEPLSEFGDLQFCLSYNDYLSRLTVVVLRAKGLQLQEDRGVVSVFVKVSLMNHNKFVKCKRTSAVLGSVNPVYNETFSFKADANELDTASLSLVVLQITEGDKSYPLGRVVVGPYMYTRGKELEHWNEMLRKPKELVKRWHALCRPMEP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BQS2-1", "uniprot_id": "SYT15_HUMAN", "id": "Q9BQS2-1", "name": "Synaptotagmin-15", "aln": "MAEQLALVIGGTIGGLLLLLLIGASCCLWRRFCATLTYEELPGTPAMATTAASSGQRDRPCQPHARTQLSRPPAVPFVVPPTLQGRDWVPLHSGEWADAPWDPCPASELLPHTSSGGLGD----ACMVGAINPELYKFPEDKSETDFPDGCLGRLWFSVEYEQEAERLLVGLIKAQHLQAPSETCSPLVKLYLLPDERRFLQSKTKRKTSNPQFDEHFIFQVSSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVIWRDLEAESLEPPSEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKVSLMNHNKFVKCKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRGRELEHWDEMLSKPKELVKRWHALCRTTEP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******::** *** ****** *****:*:*:*:****** *. ** : * :.:* : :: * *:*******: ****** **.*:** ** ****..* :. *** *: * :*:******* .** **:.***************:**:*****.*****:**.*:****.****:****:*******:*:* .****** ********:::**********::::******************.** :*:*******:.*** *****:***********************:*****.:*******************:*******:***********.*:.*********.*:* **:** **************:*****.*** **************. **", "identical_positions": 310, "similar_positions": 67, "identity": "72.94%" }, { "cls_id": "homologset.agr.HGNC:17168", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U1Z0-1", "uniprot_id": "RBGPR_RAT", "id": "Q5U1Z0-1", "name": "Rab3 GTPase-activating protein non-catalytic subunit", "aln": "MACSIVQFCSFQDLQSARDFLFPQLREETP-GALRRDPSKTSNWEDDSWGAWEETEPQEPEEEGN-TSKTQKHSWLQECVLSLSPTSDLMVIAREQKAAFLVRKWKHSDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTEG-VLLLAQLLNEDRVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGL-QDIDTIIDHASIGIMTLS-PFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFSAASGWLGWKSKHEEETVQKQKPKMEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQIVEDLHERVPEKGDFSPFGNTQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMG-------LNNVTSQSWQPQTYQICLVDPVSASVKAVNVPFHLALSDKKSERAKDLHLVKKLAALLRAKSP--RPDSFEAEIKELILDIKYPATKKQALESILASDRVSFSCLRNVTQTSMDTLKNQELESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLRALLEKYKQENTKATVRFSEDADGVLPVKTFLEYLDYEK-DALSIRKTSEEECVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQQLLSLLLSVWLSK---EKDILDKPQSVCCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENNGAALLSAHVGHSVAAQMSSSATDKKFSQMVLDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSRASPPAAKASSPQTEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCAN------------------REKDVENPDEPREGIARSPPEVSEVETDLGAVPDLLRLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRSIEHLRHILNP--HVQNGISLMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTALTSFLGSCLDLLQTSLEADIS---------------RDEVQVPVLDTEDAWLSVEGPTSIVELALEQKPIHYPLVEHHSILCSILYAAMSFSLKSVKPLA-LFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHS--KDKDPSARAADT-HGQDLNWTALAVDLAHHLQVSEDVIRRHYVGELYSYGADLLGEEAILQVQDKEVLASQLLVLTGQRLAHALFHT--QTKEGMELLARLPPTLCTWLKAMNPQDLQNTGVP-----VAATAKLVHKVMELLPEKHG-QYSLALHLIEAVEAMATL--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BMG7-1", "uniprot_id": "RBGPR_MOUSE", "id": "Q8BMG7-1", "name": "Rab3 GTPase-activating protein non-catalytic subunit", "aln": "MACSIVQFCSFQDLQSARDFLFPHLREETP-GALKRDPSKTSSWEDDSWGAWEETEPREPEEEGN-TSKTQKNSWLQECVLSLSPTSDLMVIAREQKAAFLVRKWKHGDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTEG-VLLLAQLLNEDKVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGL-QDIDTIIDHASVGIMTLS-PFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFSAASGWLGWKSKHEEDTVQKQKPKMEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQVGWIQIVEDLHERVPEKGGFSPFGNTQGPSRVAQFLVIYAPRRGILEVWNTQQGPRVGAFNVGKHCRLLYPGYKIMG-------LNNVTSQSWQPQTYQICLVDPVSASVKAVNVPFHLALSDKKSERAKDLHLVKKLSALLRAKSP--RPDSFETEIKELILDIKYPATKKQALESILASDRLSFSCLRNVTQTLMDTLKNQELESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLRALLEKYKQENTKATVRFSEDADRVLPVKTFLEYLEYEK-DALSIRKIGEEECVALGSFFFWKCLHGKSSTEEMCHSLESAGLSPQQLLSLLLSVWLSK---EKDILDKPQSVCCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENSGAALLSAHVGHSVAAQMSSGATDKKFSQMELDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSKLSPPAAKAPSLQSEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCAN------------------KERDVENPDEPRE--------------------DLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRSIEHLKQILNP--HVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTALTSFLGSCLELLQTSLEADIS---------------RDEVQVPVLDTEDAWLSVEGPISIVELALEQKPIHYPLVEHHSVLCSILYASMRFSLKSVKPLA-LFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHS--KDKDPSAEAANT-HWKDLNWPGLAVDLAHHLQVSDDVIRRHYVGELYSHGADLLGEEAIFQVQDKEVLASQLLVLTGQRLAHALFHT--QTKEGMELLARLPPTLCTWLKAMNPQDLQNTGVP-----IAATAKLVHKVMELLPEKHG-QYSLALHLIDAVEAMATL--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H2M9-1", "uniprot_id": "RBGPR_HUMAN", "id": "Q9H2M9-1", "name": "Rab3 GTPase-activating protein non-catalytic subunit", "aln": "MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEPEEEGN-TCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGL-QDIDTIIDHASVGIMTLS-PFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMG-------LNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKTKSP--NLDLVETEIKELILDIKYPATKKQALESILASERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLDTPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYEK-DVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSK---EKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLAN------------------EERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKQIFNA--HVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVS---------------RDEIQVPVLDTEDAWLSVEGPISIVELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLS-LFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLAHHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHT--QTKEGMELLARLPPTLCTWLKAMDPQDLQNTEVP-----IATTAKLVNKVIELLPEKHG-QYGLALHLIEAVEAISLPSL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6YTS4-1", "uniprot_id": "A0A8M6YTS4_DANRE", "id": "A0A8M6YTS4-1", "name": "", "aln": "MSCCLLEFGRVQELRQVREFLFPKHNSTGPEGDKAQAENELT-WDDSDWGSWDNPEGKEDGAQAEEEEQHQSAPWLQDCVVSLSPCTDLLVIAREHKAAFLSAKWRTAESGQEEMTLTVTWSGTLSIEEGESINSVICIPLASQKRSSTGRPDWTCIVVGFSSGYVRFYTESGVLLLAQLLHEDPVLRLKCRTYEIPRHPGVTEQHEELSILYPAALVTIDGFSLFQSLRACRNQVARAAAAGSDVIQPPPLAYKKWGL-QDMDTIADHSSIGITTLS-VFDQMKNASILGGFHASVKGSPPAMSQYITVGGGPYTGFFYAIEGSSQPLLSHVALAVASKLTSALFSAASGWLGWKSKNEEESVQKQKPKVEPATALPVRFGLPDSRRHGESICLSPCNTMAGVTDDFGRVTLLDVARGIAIRMWKGYRDAQLGWVQVSEARGERDIATS-------PSMPRRHAQFLVIYAPRRGILEVWGTQHGPRVGAFTVGKHCRLLYGGHRLMG-------VNSVTSQGWQIHTQQVCLFDPVNGALRAITIPFHLALSDKKSERAKDMHLLRRLTTLLRSREV--EPALLESEAQSVLLDIKHPAIKKQALESLLSNKNAPVSCLTSVTRALLASLKEQDPEAVDESLLQFCSSQLKLLQLYTDVQLLHTPDTSPTEPEHPS-----FSGIEEDLARVGPVLQRYTEMNSRPSVSFAQDSSGPLPVRTFLSLLEWVN-GELRVIKQPDTDWTQLGSFLFWGCLSGQSPLQRVCATLQESGISPQQLLSLLLTVWLNK---EKDVLKCPDAVSHLKTLLSTLSSIKGAVDESWDGQCVSPWWQQVRTACVQSESSAAALLAALVAHHVAKNAITKLAESKF------------QEGWECVSLELEQWVVCIKQLEDVLALQTLLCLP-SPQGSTGS-----AVTRCSVKTLLESGRGGVADCVSKLIFRQGVSPDVLREIL------------------QQRRENEPTQQPLLLRGE-----------GKIEELLECVCQRFPNSLSTDVLFAHCSWENVVQWNKDPEVGQYLEWSVEFLKMISNP--HIQLGVSAMMWQTFIVKRFSAAAFLIEKVGKAPKDRLCRRDVGMGDAAVRSFLGSCVQLLQALMEVSSSSFLPSYPFFSRADSAVEEVPPPDVCVEEAWSAADGPVSIVELALDQRSVHYPLVQHHCVLATLLHAAMTFSLR-LKPLS-LFDSKGKNAFFRDLASIQLLPSGDMDPNLVAVRQEFLMNVLTGWVKVLGEAEENGVRSSGSEDT-------WPHVCMELSSLLQVNTDILRRHLVCELYNQGLDLRAEEVMMEVQDKDVLGSQLLVLTGQRLSFSLLHSQSQTKPNMELLARLPPTLCTWLKAMDPSELRCPSVP-----LSQSSRLISKVIEMLPENHA-QYSLALHLLEAVDSLHQEP-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VKB9-1", "uniprot_id": "RBGPR_DROME", "id": "Q9VKB9-1", "name": "Rab3 GTPase-activating protein non-catalytic subunit", "aln": "MACEVKHCGEIRDFKKVQEYFG----------------------------------------------LGHDDNWLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGN---TYVLGWCGELEDPN-QIVTSLTCLPMT-QNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQS--APRHS---EADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQEREAVINDAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYKTMSLGEVAKDVIGIAYKNLLG---GIFRRAPEPLPSPEESPLPVPTKEAPMRIRCRLYDGKRDGLTLSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKEKSVRG------------IKTHKRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNSSSQSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEALQEIGELASELQTLEVRQQCLEMLLKSKKLQPQVFQSIINAFIKKPLSES--TGSEEFVNQIENYKRLTDLYLALSQANQREDNEPPVEYLELSDADLVTINKLVLLLDDGTEKDKPAATREVSFKLQAEHKTEEFVDYLSIFNIDSPDGISLLPEKSDKFGAVSIDLFSQFFAQGLCFGQFKQWINQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAMVQTICDLAGEHIHDYAYNAISPWWQEVRELLLESKQ-FSGLLVAIVCKTVATNLWRNRKEGSCDESSQNED----DERWERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMS-YEPPDCSLKSIVSSGKGIVTELTAKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTKESVDEDAESEEDLEMAKEVYAASKEAHEPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQLSSLDHLKAALLCLNQFRTPDWALKHGICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSAGKVPEFLELSLEFLQHFTASMEH-------------------DKRELHFEQSLS--EGALPLQFLALQQHHAMPQLLRLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPAPDLVLQQQRTEFLCRLVTATMDLIREDLEQLYILDHVFYM---------GKICALADSWEVDKLPILRRQVVELYAFGYDAEAQVLLQDISDDEELGRLLLEIAGRRLNLYAQSSQSTFLKIASVGHQLLAYLDNLKEPMTENNIQIAATKPDEIDVAALDRLLSHAYKYLCRRESKQLPIIGQMYNAVRILQN---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:* : . .:::: .:::: :. **: ::** :*:.:*: .* .** * .*: .: *.* :. : : :.* *:*:: *::*: * :***:.**: ** * ***:. * *::* :** *: :* :: ***. * .. * *:** .: *:* .:: :*. **::* :.* .. . :.::*: : *: ::: :.:::. . :* : : *: * :: :** ** ::.*. *: *** * ** . *..** * . . *:. * : .: .. :. * :.: :* * *.:*.* ::.::* . :* ***::.** *:*. :.* :*:******** .:: * . . * * ******** * *::* *:**:*.**.*.* :*:* .: :* *. :.. . : :.** ..::: : :*** ***:..*: ::*:*::::* *:: . * .: ::: ::*.** :* ... . : .: .: : . .:. : .* ::: . :* .** :. : : . : :: : : :: . :: : . :*. :: . . : : . . :. :* : . ::.: :..: **.*:: .**.* :: . : :. : :::. :..: . : :.:*****::* ::*:. :.** * * : ** : : . : ** :* : * : :*** * ::* . . . *:*.::..*:* ::: .:* :: . *. : :. :: : : * :** **. .** : .*: :***.*: . .: :: *. : .. :: *:. *:*:: : :.**: *::***: * *::*::*: *. : .** .:::** : *:: :*. .: ***:*: *:. : *.::*: *.*: ***: **** .::*:: *: . * : * :** .:::. :. . : *: :*. : *: * *** * * .: : :: *.: *. ** ::*:** : .: :* . * . :.* .::: . . :: :*: :. : * .... * : :: :** : ", "identical_positions": 265, "similar_positions": 454, "identity": "18.24%" }, { "cls_id": "homologset.agr.HGNC:17169", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z0V5-1", "uniprot_id": "PRDX4_RAT", "id": "Q9Z0V5-1", "name": "Peroxiredoxin-4", "aln": "METWSKLLDGTTPSRRW-RKLVLLLPPLLLFLLQTEALQGLESDDRFRTRENECHFYAGGQVYPGEVSRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O08807-1", "uniprot_id": "PRDX4_MOUSE", "id": "O08807-1", "name": "Peroxiredoxin-4", "aln": "MEARSKLLDGTTASRRWTRKLVLLLPPLLLFLLRTESLQGLESDERFRTRENECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13162-1", "uniprot_id": "PRDX4_HUMAN", "id": "Q13162-1", "name": "Peroxiredoxin-4", "aln": "MEALP-LLAATTPDHGRHRRLLLL--PLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9V3Q4-1", "uniprot_id": "Q9V3Q4_DROME", "id": "Q9V3Q4-1", "name": "thioredoxin-dependent peroxiredoxin", "aln": "------------------------MSKYLSVLLLSAALVGAAKPED----NESCYSFAGGSVYPDQPK----GDHQLQYTKAVISKPAPQFEGTAVVNKEIVKLSLSQYLGKYVVLLFYPLDFTFVCPTEIIAFSDRIAEFKKIKTEVIGVSVDSHFTHLAWINTPRKEGGLGDVKIPLLSDLTHKISKDYGVYLESSGHALRGLFIIDQTGVLRQITMNDLPVGRSVDETIRLVQAFQYTDTHGEVCPAGWRPGADTIVPNPEEKTKYFAKNN-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34760-1", "uniprot_id": "TSA1_YEAST", "id": "P34760-1", "name": "Peroxiredoxin TSA1", "aln": "-------------------------------------------------------------------------------MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAFTFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLADTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQWTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q04120-1", "uniprot_id": "TSA2_YEAST", "id": "Q04120-1", "name": "Peroxiredoxin TSA2", "aln": "-------------------------------------------------------------------------------MVAEVQKQAPPFKKTAVVDGIFEEISLEKYKGKYVVLAFVPLAFSFVCPTEIVAFSDAAKKFEDQGAQVLFASTDSEYSLLAWTNLPRKDGGLGPVKVPLLADKNHSLSRDYGVLIEKEGIALRGLFIIDPKGIIRHITINDLSVGRNVNEALRLVEGFQWTDKNGTVLPCNWTPGAATIKPDVKDSKEYFKNANN", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :.* ** :: ***:: : ::.* .* ***:*: * ** *:*******:**.: :*.. ::*: *.**.:: *** * **::**** :.:***:* .*.:*:**** :*..* :******** .*::*:**:***.***.*:*::***:.**:**.:* * *..* **: ** * . :** * ", "identical_positions": 92, "similar_positions": 61, "identity": "33.45%" }, { "cls_id": "homologset.agr.HGNC:1717", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WVC0-1", "uniprot_id": "SEPT7_RAT", "id": "Q9WVC0-1", "name": "Septin-7", "aln": "---------------------------------MSVSARSAAAEERSVNCSTM------------------------------------------------------------AQPKNLEGYVGFANLPNQVYR--KSVKRGFEFTLMVVGESGLGKSTLINSLFLT-DLY---------------------SPEYPGPSHRIKKTVQVEQSKVLIK------EGGVQLLLTIVDTPGFGDAVDNS-NCWQPVIDYIDSKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQGHKIKIYEFPET----------------DDEEENKLVKKIKDRLPLAVVGSNTIIE-VNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKN-----------KKKGKIF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O55131-1", "uniprot_id": "SEPT7_MOUSE", "id": "O55131-1", "name": "Septin-7", "aln": "---------------------------------MSVSARSAAAEERSVNCGTM------------------------------------------------------------AQPKNLEGYVGFANLPNQVYR--KSVKRGFEFTLMVVGESGLGKSTLINSLFLT-DLY---------------------SPEYPGPSHRIKKTVQVEQSKVLIK------EGGVQLLLTIVDTPGFGDAVDNS-NCWQPVIDYIDSKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPET----------------DDEEENKLVKKIKDRLPLAVVGSNTIIE-VNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKN-----------KKKGKIF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q16181-1", "uniprot_id": "SEPT7_HUMAN", "id": "Q16181-1", "name": "Septin-7", "aln": "---------------------------------MSVSARSAAAEERSVNSSTMV-----------------------------------------------------------AQQKNLEGYVGFANLPNQVYR--KSVKRGFEFTLMVVGESGLGKSTLINSLFLT-DLY---------------------SPEYPGPSHRIKKTVQVEQSKVLIK------EGGVQLLLTIVDTPGFGDAVDNS-NCWQPVIDYIDSKFEDYLNAESRVNR-RQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPET----------------DDEEENKLVKKIKDRLPLAVVGSNTIIE-VNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKN-----------KKKGKIF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NZC4-1", "uniprot_id": "A0A8M1NZC4_DANRE", "id": "A0A8M1NZC4-1", "name": "Septin", "aln": "-----------------------------------------------------------------------------------------------------------------MAQKNLEGYVGFASLPNQVYR--KSVKRGFEFTLMVVGESGLGKSTLINSLFLT-DLY---------------------SGEYPGPSNRIKKTVQVEQSKVLMK------EGGVQLLLSIVDTPGFGDAVDNS-NCWQPVIDHIDSKFEDYLNAESRVNR-RQMPDSRVHCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMREILEHKIKIYEFPET----------------DDEEENKIVKTIKDRLPLAVVGSNTIIE-ANGKKVRGRQYPWGVAEVENGDHCDFTLLRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTCNGIDNNKAKGQLTKSPLAQMEEERREHVTKMKKMEMEMEQVFEMKVKEKVQKLKDSEGELQRRHEQMKKNLEAQHKELEERRRQFEEERSTWETQQRILEQQK--MTLEKN-----------KKKGKIF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P40797-1", "uniprot_id": "PNUT_DROME", "id": "P40797-1", "name": "Protein peanut", "aln": "MNSPRSNAVNGGSGGAISALPSTLAQLALRDKQQAASASASSATNGSSGSESLVGVGGRPPNQPPSVPVAASGKLDTSGGGASNGDSNKLTHDLQEKEHQQAQKPQKPPLPVRQKPMEIAGYVGFANLPNQVYR--KAVKRGFEFTLMVVGASGLGKSTLINSMFLS-DIYN--------------------AEQYPGPSLRKKKTVAVEATKVMLK------ENGVNLTLTVVDTPGFGDAVDNS-NCWVPILEYVDSKYEEYLTAESRVYR-KTISDSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNEIAQHKIKIYDFPATLE--------------DAAEEAKTTQNLRSRVPFAVVGANTIIE-QDGKKVRGRRYPWGLVEVENLTHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSEL---GLVDGKAR-LSNKNPLTQMEEEKREHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEKRREFEREKKEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKKGLF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32457-1", "uniprot_id": "CDC3_YEAST", "id": "P32457-1", "name": "Cell division control protein 3", "aln": "MSLKEEQVSIKQDPEQEERQHDQFNDVQIKQESQDHDGVDSQYTNGTQNDDSERFEAAESDVKVEPGLGMG-----------------------ITSSQSEKGQVLPDQPEIKFIRRQINGYVGFANLPKQWHR--RSIKNGFSFNLLCVGPDGIGKTTLMKTLFNNDDIEANLVKDYEEELANDQEEEEGQGEGHENQSQEQRHKVKIKSYESVIE------ENGVKLNLNVIDTEGFGDFLNNDQKSWDPIIKEIDSRFDQYLDAENKINR-HSINDKRIHACLYFIEPTGHYLKPLDLKFMQSVYEKCNLIPVIAKSDILTDEEILSFKKTIMNQLIQSNIELFKPPIYSN--------------DDAENSHLSERLFSSLPYAVIGSNDIVENYSGNQVRGRSYPWGVIEVDNDNHSDFNLLKNLLIKQFMEELKERTSKILYENYRSSKLAKLG----IKQDNSVFKEFDPISKQQEEKTLHEAKLAKLEIEMKTVFQQKVSEKEKKLQKSETELFARHKEMKEKLTKQLKALEDKKKQLELSIN--------SASPNVNHSPVPT-----------KKKGFLR", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q04921-1", "uniprot_id": "SPR28_YEAST", "id": "Q04921-1", "name": "Sporulation-regulated protein 28", "aln": "-----------------------------------------------------------------------------------------------------------------MFPMKDHSALEQHTLSRDELRRRKGYKKGLQLSILLLGEKGSGKSTFLNNLCGQ-DISLSDGDYDDDDDKVTNNVTPENGNAIEDIDPGYKTAHLSPGLKLVTRRVYLNDELGVPITLDIILFPGCGDNVDNS-QSSVVIKNYLDQQFANVLKEEVRIKRNTKETDGRPHVCLYFLKSTPRGVKKFDIELMKTICDKVNLIPIIPKADGLTETELNLHKDIVRQEISQNNIRVFDFKSDTLGETLALYDMDIDSSSAKSKYDNDTKIKEISPFAIVCSKTFNKNSENRVEHIRTYEWGSLVVEDQNTSDFIYLKAILLGSHLQELKDVTNNVLYENYRAKVLTEK----------KNNYDIPNYSYIDETSR-------------------GSVSNVSTRRNSASRTLGNPDTNDENAYQIHKEIDEKNRIIEDYQRKIDLLEKMLAAPHQNKV----------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : .*..: * :. *.*:.:.:: :* .* **:*:::.: *: . . . : : : . * ** : * :: * ** ::*. :. : . :*.:: : * * :: * * * : ****: .: : : :*: *: : :* *::*:*.*:* :* * .*. : .:: :*.::. . .: . : . * *:: :: : : ... : * * ** *:: .** *: ::: .:::**: *.:: *****. *: : :* .: .. :.* . . . .: : ::::.: :* ", "identical_positions": 62, "similar_positions": 131, "identity": "10.53%" }, { "cls_id": "homologset.agr.HGNC:17170", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XFW2-1", "uniprot_id": "TRUB2_RAT", "id": "Q5XFW2-1", "name": "Pseudouridylate synthase TRUB2, mitochondrial", "aln": "--MGSSGL---ARLQGLFAVYKPPGLKWLHVRETVELQLLKGLNAQQPSAPEQHVRFLLG-PVEGSEEKKLTLTATSVPSLTTHRLVRGPAFRNLKIGVGHRLDVQASGVLVLAVGHGRSLLTDMYDAHLTKDYTVRGLLGKATDNFCEDGQLIEKTTYDHVTRERLDRILAMIQGSHQKALVMYSNLDLKSQEAYERAVQGVIRPMNKSPMLIAGIRCLHFAPPEFLLEVQCMHETQQQLRRLVHEIGLELKTTAVCMQVRRTRDGFFGLDDALLRTQWDLHSIQDAIQTAAPRVARELRKN---------LSLMSGHQQQLPSAGQPWASRVQAPL-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WG3-1", "uniprot_id": "TRUB2_MOUSE", "id": "Q91WG3-1", "name": "Pseudouridylate synthase TRUB2, mitochondrial", "aln": "--MGSSGL---ARLQGLFAVYKPPGLKWLHLRETVELQLLKGLNAQQPPAPDQRVRFLLG-PVEGSEEKKLTLRATNVPSLTTHRLVRGPAFTNLKIGVGHRLDVQASGVLVLAVGHGRSLLTDMYDAHLTKDYTVRGLLGKATDNFCEDGRLIEKTTYDHVTRERLDRILAVIQGSHQKALVMYSNLDLKSQEAYEMAVQGVIRPMNKSPMLISGIRCLHFAPPEFLLEVQCMHETQQQLRKLVHEIGLELKTSAVCTQVRRTRDGFFGLDDALLRTQWDLHNIQDAIQAAAPRVAAELQKN---------LSLKLGHH-QLPSTGQPWGLKDPSSTLELESCSGQ--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6ACE3-1", "uniprot_id": "A0A8I6ACE3_RAT", "id": "A0A8I6ACE3-1", "name": "Pseudouridine synthase II N-terminal domain-containing protein", "aln": "--MGSSDP---GRLQGLFAVYKPSGLKWLHVCQTVELQLLNGLSAQQPSAPEQRVRFSLG-PVEGSEEKRLTLTATSVPSLTTHRLVCVPAFRNLKIGVGHRLDVQVSGVLVLAVGHGRSLLTDMHDAHLTKDYTVQGLLGKATDNFCEDGQLIEKTT------EWLDQILGMIQGSHQKALVMYSNLNLKRDPAHERVPN--AHRWQPIPALCT---------SRLFLRVQCMHDREQQLRRLVHEIGLELKT----TPVRCTRDGFFRQDNALLRTQWDLHSIQDAVQAAAPWVARELRKN---------LSLTSGQQQQLPSARQPWTSRPSSCHIQTNRRGEWVSYHPS--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O95900-1", "uniprot_id": "TRUB2_HUMAN", "id": "O95900-1", "name": "Pseudouridylate synthase TRUB2, mitochondrial", "aln": "--MGSAGL---SRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLG-PMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKS---------LSPGLDTK-QLPSPGWSWDSQGPSSTLGLERGAGQ--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N020-1", "uniprot_id": "A0A8M1N020_DANRE", "id": "A0A8M1N020-1", "name": "", "aln": "MKMATQAVRLFRKMDGLFAVYKPQGVHWKLVRDTIESNFLKALNSSPPAAPRREVQFQLLSSGENSTSKELILSPSMVPSLADHPLVTGPQFHKVHVGVGHRLDAFSSGVLVLGVGKGNSVLENLCKSHVTRDYTIEGEFGKATDNFSHTGRVIEKTTYDHITHDKLERVLAMLQGSNQKALITYSQVELQTQEAYELAARGLLYPDGKSPPILTGLRCIKFNPPHFTLEVRCVNETQKYLRKLIHEVGLELRASAVCTKVRRTRDGPFKVENALTRQHWTADSVLQAINHFR-KTARKIRKSGMYMQSNVRMTLDADTREQTQSEHMSGVRDVLSDMILERETPGEPNEGRTKN", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.: ::.******** *::* : :*:* ::*:.*.: *.** :.*:* * . *.* .*.* * .: ***: * ** * * ::::*******. ******.**:* :* :: .:*:*:***:.* :*****:* . *:::**** : *:::*.::***:****: **:::*: : *:* . . * : : ..: *.*:*::: :: **:*:**:****:: ** **** * :.** * :* .: :*:. .* ::.*. :: . : * * . : ", "identical_positions": 111, "similar_positions": 102, "identity": "31.27%" }, { "cls_id": "homologset.agr.HGNC:17171", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A9V5-1", "uniprot_id": "D4A9V5_RAT", "id": "D4A9V5-1", "name": "Lysyl oxidase homolog 4", "aln": "MMWPPPPTFSVFLLLLLSQVPSS----RPQSPGTKKLRLVGPANRPEEGRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKFGQGEGPIWLDNVRCLGTEDTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQQGYHSEKVSN-----ALGP----------------------QGR-------------------------RLEEVRLKPILASAKRHSPVTEGAVEVRYEGHWRQVCDQGWTMNNSRVVCGMLGFPSQAPVNSHYYRKVWNLKMKDPKSRLNGLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPACPGGMHAVVNCVAGPHFQRQKPKPKRKESGAEQELKVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYEQTIGDCLALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGTVCSDHWGLTEAMVTCRQLGLGFANFAIKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQCQRHGP---VHCSHGSGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCLSKSADHMD-----WPYGHRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQWVDITDVSPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDPYRPNAELSLEQEQRLRNNLI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q924C6-1", "uniprot_id": "LOXL4_MOUSE", "id": "Q924C6-1", "name": "Lysyl oxidase homolog 4", "aln": "MMWPQPPTFSLFLLLLLSQAPSS----RPQSSGTKKLRLVGPTDRPEEGRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKYGQGEGPIWLDNVRCLGTEKTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQHGYHSEKVSN-----ALGP----------------------QGR-------------------------RLEEVRLKPILASAKRHSPVTEGAVEVRYDGHWRQVCDQGWTMNNSRVVCGMLGFPSQTSVNSHYYRKVWNLKMKDPKSRLNSLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPACPGGMHAVVSCVAGPHFRRQKPKPTRKES-HAEELKVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYERTLGDCLALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGTVCSDHWGLTEAMVTCRQLGLGFANFALKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQCQRHGP---VHCSHGPGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCLSKSADHMD-----WPYGYRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQWVDITDVGPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDSYRANAELSLEQEQRLRNNLI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96JB6-1", "uniprot_id": "LOXL4_HUMAN", "id": "Q96JB6-1", "name": "Lysyl oxidase homolog 4", "aln": "MAWSPPATLFLFLLLLG-QPPPS----RPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDDNFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVSDCSHSEDVGVICHPRRHRGYLSETVSN-----ALGP----------------------QGR-------------------------RLEEVRLKPILASAKQHSPVTEGAVEVKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTNKNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQRKGS-WAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWFWSGTPRAQEVVMSGVRCSGTELALQQCQRHGP---VHCSHGGGRFLAGVSCMDSAPDLVMNAQLVQETAYLEDRPLSQLYCAHEENCLSKSADHMD-----WPYGYRRLLRFSTQIYNLGRTDFRPKTGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QJK9-1", "uniprot_id": "F1QJK9_DANRE", "id": "F1QJK9-1", "name": "protein-lysine 6-oxidase", "aln": "MIRVCPLCILLFALLFMCMDARPGSSGRSRRAPAAKVRLAGIGHQENEGRVEVLHNGTWGTVCDDEVDIKLANVVCRELGFQSGITWAHSARYGEGEGPIWMDNVRCEGTEKALRDCRSNGWGVHDCKHSEDLGVVCSPERRLDQTYPGVSRRGHTIALRPNPVTSNRWQDIYSNPRTPAHLRQGNGHSQDQTRWDQLSRQQLPNPSASRVRIEEVRLKPVLMVTKRRALITEGVVEVKHAGRWRQVCDKGWSLNSSRVVCGMLGFPDAEQPNMNTYKKIWDKKVKDSTTRLSQMAKKKGFWVEKLHCLGTEPSLAECHTQLSIPRS--PAPCKNGRYAVARCVPGPQFARMSS--GRPQAPHPVQLSVRLKAGPRLGEGRVEVLREGKWGTVVDHLWDRISASVVCRELGFGTAKEALTGAYMGQGTGPIHMNSVRCAGTERSILDCFFQDVQPWTFKHNRDASVKCYVPKTGVENTVRLAGGRDPAEGRVEVLMEDGGRKHWGTICSENWGINEAMVVCRQLGFGFAARAHQETYYWQGDPAAEEVVLSGAHCVGTEMSIQQCRRNSY---VHCPRGGGAKAAGVTCSETAPDLVLDAQLVQESSYLEDRPLHLLTCAHEENCLSSSASRMQ-----WPYGHRRLLRFSSRIMNLGRADFRPRASRESWTWHQCHRHYHSIEVFTHYDLLTLNGSRVAEGHKASFCLEDTYCPEGLHKRFSCYNYGDQGISVGCWDTYRHDIDCQWIDITDVRPGDYIMQVEVNPSLDMAESDFMNNVMRCRCKYDGHRVFMYGCHAGDAYSAEVEDLFEHQRQISNNFI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W2C9-1", "uniprot_id": "Q9W2C9_DROME", "id": "Q9W2C9-1", "name": "", "aln": "--------------------------------------MCAIEDR------KVLKMG-LTLVCLTLLAIHMADAVVQHR---------------------------------SLEDARQE-------------------RQRLVHRYTKVLN------------------------------------------------------------KEEGAIRLVGGDNE-----YEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMR---------------RYTRSGFFGPARRR-FWMDNLFCEGHEQELVDCHFEG---------------WGENDCEPGE------------------------------------------------------AAGVVCYPP--------------ENALIPMATPIIR-------------------------DEDLPKYPIHSRSRLYVRLRGGRSRIEGRVEVSLDGG---RWGSVCADGWSLLEANVVCRQLGLGYASEAFQTDFFGGFN--VSRPVLSGSECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIAPDLVVDYLEIEQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPFKEKSQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNCANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTYVLKIAINPEFKVAEMNYDNNAAICDLIYTANFARVQNCQLGRP--------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : :**: * ** . :: * .. :. :* :. .: .:: * . ** :: : : ** :** : *:* ***. * ..: :** ****. : . : : :.:. **:..: * * * :..*: : . * .* :*.*** :. *: :* * : . . *** *** ** :** :: . :**::*:: *.: ** *.*****:*:* * : :: ... *:** .* *.* : :* ::. : . :* *.* * *****:: ::::::*****: : ** ****::..* ::: * * ****:*:: * *.:**** : .* ** ** *:**:***: :*::.*.* :**:**********: * *: ::: * *:*:**:::.* *.* :::****:*:**: ** *:::: :** .:** :: ** * * .: . : .*: * . ", "identical_positions": 163, "similar_positions": 162, "identity": "19.83%" }, { "cls_id": "homologset.agr.HGNC:17173", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A0Z7-1", "uniprot_id": "D4A0Z7_RAT", "id": "D4A0Z7-1", "name": "Brother of CDO", "aln": "-----MVTCRGEQPMLTLLWFLLAIAGCLADLNEVP----------------------QVTVQPMSTVQKLGGTVILGCVVEPPWVNVTWRFNGKELNGS----------DDALGVLITRGTLVIAALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQH------VIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRDNYLIMPSGNLQIVNASQEDEGTYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR----IIYPLEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYN-KTRFLLSNLLIDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPPEVTVELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLSSNQRLRLSRKALRVVSVRPEDEGVYQCMAENAVGSAHAVVQLRTARPDTTLRPGRDTKPIAATPPMPPSRPNRPDQMLREQPGLVKPPTS-VQPTSLKCLGEE-QVAPAEAPVILSSPRTSKTDSYELVWRPRHEGSSRAPILYYVVKHRKVTNSSDDWIISGIPANQHHLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDDPGASLQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNG-GFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKFSGQPGRPPPLTLAPPQPPPLEAMERPMGTGAMVARASDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALLSSSCQYTMVPLGGLPGHQANGQPYLSGIGGRACVSRLHGSRGYPAATVGCPGRKLQQHCPGELAQQREDSNSLLRQPIVSNGYDLQNQQVARGTKSGSEEGSFLYTLPDDSTHQLLQPQ-DCCHLQKQPVTTCQTAVRRAPEGPGLEASWDPQYHSGPRCCLGLVPVEEVDSSDSCQVGGGDCCPQHPSG------------------TYTGQELGVRLSPSPSVHVSFETPPPTI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6AZB0-1", "uniprot_id": "BOC_MOUSE", "id": "Q6AZB0-1", "name": "Brother of CDO", "aln": "-----MTTCRRERPILTLLWILMATAGCLADLNEVP----------------------QVTVQPMSTVQKLGGTVILGCVVEPPWMNVTWRFNGKELNGS----------DDALGVFITRGTLVIAALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQH------VIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRDNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSGDRLRVRRSTAEAAR----IIYPLEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYN-KTRFLLSNLLIDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPPEVTVELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLTSSQRLRLSRRALRVVSVGPEDEGVYQCMAENAVGSAHAVVQLRTARPDTTLRPGRDTKPIAATPPMPPSRPSRPDQMLREQPGLVKPPTSSVQPTSLKCPGEE-QVAPAEAPIILSSPRTSKTDSYELVWRPRHEGSSRTPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDDPGASLQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNG-GFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKFSGQPGRPPPLTLAPPQPPPLETMERPVGTGAMVARASDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALLSSSCQYTMVPLEGLPGHQANGQPYLGGVSGRACVSRVHGSRGCPAATVGCPGRKPQQHCPGELAQQREDTNSQLRQPIVSNGYDLQNQQVARGPQCASGVGAFLYTLPDDSTHQLLQPQ-DCCHLQKQPVTTCQTAVRRTSESPGLESSWDPPYHSGPRCCLGLVPVEEVDSSDSCQVGGGDWSSQHPSG------------------TYTGQERGMRFSPSPSVHVSFETPPPTI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BWV1-1", "uniprot_id": "BOC_HUMAN", "id": "Q9BWV1-1", "name": "Brother of CDO", "aln": "MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVP----------------------QVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGS----------DDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQH------VIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR----IIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYN-KTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTS-VGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNG-GFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPP-SCPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQ-SDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVG------------------AYVGQEPGMQLSPGPLVRVSFETPPLTI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VM64-1", "uniprot_id": "IHOG_DROME", "id": "Q9VM64-1", "name": "Interference hedgehog", "aln": "-----MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPAHPAHPAHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVS-QEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESE---SPLQWRVSAGNSVLWSCGQ-QVQSNPSASWSYYRNGVEIKP--EFIGTNGNLFLSNVSSESSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRP--ALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQ-------EPR----------ESGGTHRPKPNQGSRQKQ--------MYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYR------MVG----KRKNWQTTNDNIPYG----------KPKWNS-------ELG---KSFTASVTDLKPQHTYRFRILAVYSNNDNKE--SNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHAR-SFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCRRRNSRSRGNNPNKPRMAELR--------------------DDFVP-----LGNCSPTKQRQRTR----HIHITLNPLAQQQQQ-----------------------------ALEEKNDTDQ-------------------------------------------DAP-------------------------------------------------------------------YYQRPSSYDYDPTLRRMSS--------------------SSLRRSQRTLERAGGSN-----------GSNNGNNNNLNQSAEAGSIEN-PGKPG---------------------RVLMKRPRLSSRSENLSSGSLNSVGV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A8JUV7-1", "uniprot_id": "A8JUV7_DROME", "id": "A8JUV7-1", "name": "Interference hedgehog", "aln": "-----MAEIRLVVVLLVLMTT---CIYTLQASDSN--------------SSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDRLEWRFRRGDSSEP-YLYLRPSAGYNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGALASTPARLALVSIALDVGQGSMGARSSIRWSVAPKNCLLIRCG--SVISNPPAIWSFYRNGKKLPQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTP---PYFLQRPP--IEYSARPGETVVLECPGVGSPRPRVIWSSPNVV-EIYNNRSTILSYGLQITDVKPEDQGSYICMLDNGIAP--PIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNPQPDIYWLINGEDATKDPEAVVDNRSLQLKRVQKRHAGVVQCFAKNILGETSEGNILRVNPLEITG---EDDEPLGEVPVWPVHESNTGMGTSSTSGGSKNKSGRRKFKASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQITFFKVQYR------MLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKE--GNTSLKFFLQNGTSKSNLPVPELREVETLSESAVVLHWSLVSSTQNEDIDGYYAYYRPADSAAEYLKATVDGGMSR-SFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKTHEQPASSSATPVPANKAVEQHQNSLY---PLIAGAAGGGILLLIASLVVCLCLKRRENSQP--EDENKPQLEHIQ--------------------ADFVTSAVLGVGGHHKSGDVRRLNGVIPRMNITPNPLAQETASDKNRNVMELRFLPPLANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEACDAAIKLNLPQKHDQEQLDAPNAVLEAPSKPLPPLPKKPANGAGQNNSGLHQNGLHHAQPYHPPGTPTLMHKRLDYHQQPPPVPPHSAYYQQAPTHQPSPMMERSVRGHQQPGGFHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHSNLN----IGLSHHNNNNNNLPPHHQHLHHHPGHPGGLVGIPIVPGSPRVQRSPMPSRAMIKRTRLGSHTDNISSGSLNSIEV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *. . * : . * * * *. *:: * . .. * . . . : : .* * *:**. . .::*. * : *.. : . * * : * . .:. . :* :: : : . * * : ..: :. * *.* * *. : : .*:* : *.:::* * . * * * * *:. . * :: .: * * . :* *:* *: .**: . :: * : * : : .: * *.. * * *.: ** *. .. . :... * : : .. * **:*.* :*. *:. . : . . . . :: .::* . : . .:: ::. :: :** :::.* * . . . :::. : . : : .*:* .:: ::: . : . . .*: :. **::* : * .. * .: . *: ....::: ** :* *.:* *. . *:*:::::. . ** ** : . . . . . :: : : ... : : . .. .. : :* : : * . : : :: .. :. ..:** : * :: : . . . . :* ::.. . * . . :", "identical_positions": 98, "similar_positions": 237, "identity": "8.31%" }, { "cls_id": "homologset.agr.HGNC:17174", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P81799-1", "uniprot_id": "NAGK_RAT", "id": "P81799-1", "name": "N-acetyl-D-glucosamine kinase", "aln": "MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTGTCVERINEMVDRAKRKAGVDPLVPLRSLGLSLSGGEQEDAVRLLMEELRDRFPYLSESYFITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFNYFQVPDRLGILTHLYRDFDKSKFAGFCQKIAEGAQQGDPLSRFIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTQGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGHHLPMDYSVNAIAFYSYTF-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZ08-1", "uniprot_id": "NAGK_MOUSE", "id": "Q9QZ08-1", "name": "N-acetyl-D-glucosamine kinase", "aln": "MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTDQCVERINEMVDRAKQKAGVDPLVPLRSLGLSLSGGEQEDAVRLLIEELRHRFPNLSENYLITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFDYFQVPDRLGILTHLYRDFDKCKFAGFCQKIAEGAHQGDPLSRYIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTLGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGYHLPMDYSINAIAFYSYTF-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJ70-1", "uniprot_id": "NAGK_HUMAN", "id": "Q9UJ70-1", "name": "N-acetyl-D-glucosamine kinase", "aln": "MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKAGVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFSSFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IUJ5-1", "uniprot_id": "A0A0R4IUJ5_DANRE", "id": "A0A0R4IUJ5-1", "name": "N-acetyl-D-glucosamine kinase", "aln": "MSAVYGGVEGGGTHSKAVLVSAEGDILAETDGPCTNHWLVGVDNCISGINEMVQSAKIKAGLDPDTPICSLGMSLSGGEQKAAIQKLIDDMHERYPKLSQSYFITTDAIGAMATASDYGGIVVISGTGSNCKLVNPDGTQIGCGGWGHMMGDEGSAYWISHLAVKTVFDARDNLVTSPHDITYVKKAMEDYFQVSDLMGMLPHLYRNFQKSHFAGFCRKLAEGGNAGDALCQHVFREAGKVLAQHIVAVLPEVHQDLFRGELGLPVLCVGSVWRSWELMKSGFTQVLSQAQS-HDYSHFRKYSLLTLRQSSALGGAKMGAKNIGTTLPLDYSANVNMFFSHTFTQ-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VF86-1", "uniprot_id": "Q9VF86_DROME", "id": "Q9VF86-1", "name": "N-acetyl-D-glucosamine kinase", "aln": "-MKYFGGVEGGATHSRLVICDESGQSVGATSGLGTNHWGIGIPECARRIADMVERAKEEAGIPKETPLTSLGLSLSGCEQEATNRELEQELRTTFPGLAQNYAVSSDTMGSMYTASSIGGMVLISGTGSNCLLRNPDGSTSNCGGWGNFLGDEGSAWYISYRAVKVVFDHMDNFEQSAAPVEKTWSLIKEHFSLETRLDMLPHCYAKFDKPFFANLCKKLSQNAENGDELARSLFREAGVHLARMILALLPNVHQDLVK-SGDLSVVCVGSVWSSWDLLQEAFISELAKTTIDFDLK------LVRITKSSAYGACYLGADSADFDLPRNYADNVTVLYTYTDPRKKAKATNGCNC", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :******.*:*. :: . .*. :. :.* **** :* * * :**: ** :**: .*: ***:**** :*: : : * :::: :* *::.* :::*: *:: **: **:*:******** * ****: .*****:::******::*:: *** *** **: :. : . . : .:*.: :.:*.* * .*:* **.:*:*:::... ** *.: :**:** *.: ::*:**::. *.: . .*.::****** **:*::..* *: . *: : :*** *.. :** . ** :*: *. ::::* ", "identical_positions": 122, "similar_positions": 117, "identity": "34.27%" }, { "cls_id": "homologset.agr.HGNC:17175", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99P84-1", "uniprot_id": "PLCE1_RAT", "id": "Q99P84-1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "aln": "MTSEEMAASFLIPVPQRKVASAQSVAEERGEKVSEAGIPKTRAGRQGGLTPRTISQRNEPEEESPRTDFSQVFSIARGELDSDENHNERCWEENVPGSTKNHAVNCNSLLQSHQHALPPSQLCEVCDSVTEEHLCLQPGIPSPLERKVFPGIELEMEDSPMDVSPLGNQPGIMESSGPHSDRNMAVFHFHYAGDRTMPGAFHTLSEKFILDDCANCVTLPGGQ--QNKNYMAYTCKLVELTRTCGSKNGQLKCDHCTSLRDEYLCFESSCRKAEALSSGGGFCEDGFTHGPSAKTFLNPLEEFSDNCEDVDD--IFKGKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLAAWSYVDQKKAGLMWPCGNGMRPLSTVDVRQSGRQRLSEAQWCLIYSAVRR-EETEDTVGSLLHCSTQLPTPDTAHGRIGDGPCLKQCVRDSECEYRATLQRTSIAQYITGSLLEATTSLGARSSLLSSFGGSTGRIMLKERQPGTSMANSSPVPSSSAGISKELIDLQPLIQFPEEVASILTEQEQNIYRRVLPMDYLCFLTRDLSSPECQRSLPRLKACISESILMSQSGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSVEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLLKLCPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNPEKELTVNSIFQIIRSCSRSLETED-EESASEGSGSRKNSLKDKTRWQ---------FIIGDLLDSDNDIFEKSKE-CDPHGSEESQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTASPAGARLKLGVLSNVAEPGKFPSLGNAGVSGLVEGILDLFSVKAVYMGHPGIDIHTVCVQNKLSSMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTTAVRKIRKFPDQRQQWLRKQYVSFYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPNMQRNNTLGIST-TKKKKKMLMRGESGEVTDDEMATRKAKMYRECRSRSGSDPQEANEQEDSEANVITNPPNPLHSRR---------AYSLTTAGSPNLATGMSSPIS----------------AWSSSSWHGRIKGGMKGFQSFMVSDSNMSFIEFVELFKSFSIRSRKDLKDIFDIYSVPCNRSASESTPLYTNLTIEENTNDLQPDLDLLTRNVSDLGLFMKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPNISMCHQGLLSFEGFARFLMDKDNFASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQTQAFTGGNANPPPASNEEEEDEEDEYDYDYESLSD--------------DNILEDRPENKSCADKLQFEYNEEVPKRIKKADNSSGNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSGRGKERKSRKSIFGNNPGRMSPGETASFNRTSGKSSCEGIRQIWEEP--PLSPNTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDAMDPATYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQLRNLHNEILEISSLFINSRRMEDNPSGSTRPASLMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQILAVDQDTKLTAADYFLMEEKHFISKEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKP--QQETLEEKNIVHDDREVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPNPCDYVLLEEVMKDAPNKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKRRGISFASELKKLTKSTKQTRGLTSPPQLVASESVQSKEEKPMGALASGDTAGYQS--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K4S1-1", "uniprot_id": "PLCE1_MOUSE", "id": "Q8K4S1-1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "aln": "MTSEEMAASVLIPVTQRKVASAQSVAEERSVKVSDAGIPRARAGRQGALIPPTISQWNKHKEESSRSDLSKVFSIARGELVCDENSNEEGWEENAPDSPENHAMNGNSLVQSHQHQFPRSQLCEARDSVTEDP-CLQPGIPSPLERKVLPGIQLEMEDSPMDVSPAGSQPRIMESSGPHSDRNTAVFHFHYEADRTMSDAFHTLSENLILDDCANCVTLPGGQ--QNKNCMAYACKLVELTRTCGSKNGQVQCEHCTSLRDEYLCFESSCSKADEVCSGGGFCEDGFAHGPAAKTFLNPLEDFSDNCEDVDD--FFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLPSGCIGPAAWNYVDQKKAGLLWPCGNVMGTLSAMDIRQSGSQRLSEAQWCLIYSAVRRGEEIEDTVGSLLHCSTQLPNSETAHGRIEDGPCLKQCVRDTECEFRATLQRTSIAQYITGSLLEATTSLGARSGLLSSFGGSTGRIMLKERQLGTSMANSNPVPSSSAGISKELIDLQPLIQFPEEVASILTEQEQNIYRRVLPMDYLCFLTRDLSSPECQRSLPRLKASISESILTSQSGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSVEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLLKLCPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNSEKELTVNSIFQVIRSCSRSLEMEE-EDSASEGSGSRKNSLKDKARWQ---------FIIGDLLDSENDIFEKSKE-CDPHGSEESQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTASPAGARPKLGVLSNMAEPGKFPSPGNAGVSGLAEGILDLFSVKAVYMGHPGIDIHTVCVQNKLSSMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAEMLFSGLLELTTAVRKIRRFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPNMQRNNTLGIST-TKKKKKMLMRGESGEVTDDEMATRKAKMYRECRSRSGSDPQDVNEQEESEANVITNPPNPLHSRR---------AYSLTTAGSPNLATGMSSPIS----------------AWSSSSWHGRIRGGMQGFQSFMVSDSNMSFVEFVELFKSFSIRSRKDLKDIFDIYSVPCNRSASESAPLYTNLTIEENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNFASKNDESRENKKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAFTGGNANPPPASNEEEEDEEDEYDYDYESLSD--------------DNILEDRPENKSCADKLQFEYNEEVPKRIKKADNSSGNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSSRGKERKSRKSIFGNNPGRMSPGETAPFNRTSGKGSCEGMRHTWEESS-PLSPSTSLSAIIRTPKCYHISSLNENAAKRLCRRGSQKLIQHTAYQLLRTYPAATRIDSSNPNPIMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDNLDPAIYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVVENNSSAITAQRIIPLRALKRGYRHLQLRNLHNEILEISSLFINSRRMEENPSGSSMPASLMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQVLAVDQDTKCTATDYFLMEEKHFISKEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKP--QQETLEEKSIVFDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPNPCDYVLLEEVLKDAANKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKRRGISFASELKKLTKSTKQSRGLPSPPQLVASESVQSKEEKPVGALSSSDTVGYQQ--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P212-1", "uniprot_id": "PLCE1_HUMAN", "id": "Q9P212-1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "aln": "MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKLKEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQRQFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHFEDFPDNCDDVEED-AFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTAWSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRR-EETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDE-EDSPSEGNSSRKSSLKDKSRWQ---------FIIGDLLDSDNDIFEQSKE-YDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGIST-TKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRR---------AHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSD--------------DNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKT--QQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ--------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PWG9-1", "uniprot_id": "A0A8M9PWG9_DANRE", "id": "A0A8M9PWG9-1", "name": "Phosphoinositide phospholipase C", "aln": "-----MRLHVERQAHIGIKSSMASNRASPVLGVKSLGKETSSNGDARLLMNYSLPG-GTPPQTPVHLEGDSVGTVCRIWKSLDIRSKS---LDCLDETFRSKNCSCEAIRHREEGSYN-FHMCGFCDSVENAEGCPKN-TFSPRSWGTVP-QKRKAEAFSSGITSLDEPRPTLSGSDGELCPKELVISQNMENLPFCG---------LDLRRSSVPVSTPQGP------QCANGCGTAENNKMRN----RLDFLCAVCHKNGFSSLERLNRNTKPMCSKGKPLKR-------SKPFRFSVPDSSDGEGTVSDSEFVRNRKDRSTVLVRRYLKNNQKFKKTVCTGTKAIVKTLPTGCISDRIWESVCNERSR-----HEASGHSKALQAIQLQVSRALLAYPGARLAEIDHAAPTLSPEVSLLHRSRKLLAQAVSWPPVS----------PSQIRFRACHRRISIAAHLSGALLEATAALGARTSLPSFTVGSTGRAMLKERQLCSSMANSSILPSAVTGISKELADLRHLIQFPEEIATILTEQEQQLYRRVFPLDYLSFLTRDLGSPECHKRHPHLKASLSAPIMPTQNDNHNTVEDLVTRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCSWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQADIETMRGLKDAMAQHESSSEYKKVVSRALNIPGCKVVPFCGVFLKELSEALDGAASIIGLRPSFDSQEDPVEFVTDYNGQQHFLQRLGSDGLHSSDKEATVSNILQTIRSCNRSLEAEEPEERAREITVCPKNSFKDKSRNQKGPGTERVLFSIGDLSDSEGDPLETVKDVVDLQTTEDVRGPFSHGTELIPWYVLSLQPDIHQFLLQGATVIHYDPESHLTARCLLRLQPDNCFLTWCKPHSSCSLYGRART-FMGHPASPDHLH-IGQPVHCGLSDGLLDLNVVKAVFMGHPGVDVNYVCLQHKLCNMNPGENGVTLLYGLHTTDNRLLHFVAPKHTARMLHEGLQELLNSIRKIRKFPDQRLQWLRKQYVSLYQEDGRFEGPTLAHAIELFGGRRWNMGTSGPGSASRGAEKNSAQKNSPLGINSNVKKKKKALVRGDSGDGTDDEMTARKTRSCKETLGRRESDALENVEQEEAEDCSTFSQPGPFSLSNNKGQSPGSSSSSSTSSSVASFCTNSSTPTRPHSSPILPTNLKSQPGAWSSRSWHGRGKGCFRGFQDLMISDSIMSFVEFVELFKSFSIRSRKDLKELFDTYAVPCSRSGPESVPLYTTLRIDDKLTGLQPDLDLLTRNGSDLGLFIRTRQQMSENQKQISDAIAAASIVTNGTGVENSSLGVLGLAISQLNDFLVNCQREHLSYDEILSIIQKFEPSSNMRQMGWMSFEGFARFLMDKDNFASKNEESQVNLDELQHPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPVIYHGHTLTTKIPFKDVVEAINRAAFVNSEMPVILSIENHCSLPQQRKMAEIFKMVFGEKLVTKFLFESDFADEPLLPSPLQLRGKILLKNKKLKAHQAPVDILKQKAHQLAHMQAQANNGTVSTTPLGNNDEEEEEEDEYDYDYESLSDADVLNASTASYGQEDNILDDKPEGKSSTEKLQYESNDEMPKRFKKAGS----KGKMFDMELGEEFYLPQNEKESRQIAQELSDLVIYCQAIKFPGLSTLSPSGSGRGKDRKSRKSIFGSAPARGSPGEPVTLVRAPGKASLEGIRMNSEDQ-LCLSPSTSLSSIIRTPKCYHISSVNENAAKRLCRRYSQKLIQHTSCQLLRTYPAATRIDSANPNPLIFWLHGVQLVALNYQTDDLPMQLNAALFEANGHCGFVLKPPVLWDRSCPLYQHFYPLDRDLENMTPTLYTLTIVSGQNVCPGNSNGSPCVEVEVLGMPADSCHFRTKPIHRNTLNPMWNEHFQFHVHFEDLAFLRIAVVENNSSQVTAQRILPLKTLRAGYRHLQLRNLHNEPLEVSSLFMFSRRTEESPTGGPPSASVLFSTEERRSVQQHKVTVHGVPGPEPFTVICVDEFTTAKQLLDSLFP------TASFKYMLMEERVSLSKEK----KAPQQRPLANDERLLKLIHSWQPEDGYVGRIYLKTREQQNCSEKTSVPLESLEELGSLEDDTFFVQVHDVSPEQPHTVIKAPRYSTAQDIIQQTLSKAKYSLSILSNPNPCDYVLMEELCKDAGGKKSSSAKPCQRVLQDHECVFQAQSRWKGAGKFILKLKEQLAR--EDKRKGVSFASELRKLTGRSRSVTVNTNSNDTHRSLSLGLKAWMAEGRLGSPRRSQCGDGVSALSGWSLPLLWNWKLHK", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . * * . *.. . : ::. . : . : .: ::.* * . :. . : .. . : : : .: :: :** : * : ** . ..* : : : . .::. .. :. . . . *: : : * .. *. * * * * * : . ::. . .: : .:* :.. : * . . :*.* . : .*. *.: .:.:*:***:****: **:::.**:* ***:**::***:* *. *. : ::: . .::: * .* * : : .. **** :* .: : : .:** :* **: :::*:*****::****:.* * ***** ****** .*:***. :**: :****** **: *******:*:** **** :****:*:***.******.:***: * ***.:* .*: :*..:**::**** ***********************************.******************************:******.*********** **:***:***:*****************.*.****:.:: * * :.***:.:***:**.**::****:*.:**:..:** **..*:* ****.**** :: *: . * . . *.*:***:* * * **** **:.* :* *: * : :*: : .*.************:*.*:************** ::**:***:*:*****. *** ** ::.. .: : .:.: *.*.:: *:. ..* :*:*** ****:*****:*:: **:*:** .* .*.********:****************.**..** ** ::**:*:***** *********:******:********:********. ...** :::.*** . *:*..***.: .***** *:**:**: *****::**:: :* .* **. : ***::* . *.*: . : * *::. ..:.:. *:* **** ***** :* ::***.:*:*** ***:**********:*******::** *:***.**..**.****.* *::: ..*********** ******::::**:*:**:*****************:*.:***::*:.* ********** ** :*************. .* : * :************:******:**: * .:** ***************************************:************:**************:*****:*:**:.*::*:*:******************* *******:*****:**:*:*:**** *** *:***********:************* **.** .* :.. ..*:***:************** ****:*:**.**. :***:* *:*:***:***.. ***::********** **:******* ***********:********..***.***:*********. *.* ****...: ::.**.* **:* *: *.*.****:************:*********** **** ***: **************:****::*****:*************::****:***** **:*********:.**:**:* **:***: : *: *:***:*******.** ****:**:***** *********************:* *:******.***:******** :*****:**::*: ************* **:****: *** *:..:*.. .** :*.****:. * *:************:*: :: *.*****:.::. .: .*:****: :**** * * **.:. :* ::::: ** **:**:*** **. **: *:..: :. * : * *:::*************:******* *****:*****.***** ***.****.****:**: **: .**:::.*..**:* *:********:**************: ***::*:******:*** ::. ... : * *: * . * *.* . ", "identical_positions": 1250, "similar_positions": 530, "identity": "52.94%" }, { "cls_id": "homologset.agr.HGNC:17176", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B4F7C7-1", "uniprot_id": "B4F7C7_RAT", "id": "B4F7C7-1", "name": "Heme-binding protein 1", "aln": "--------------------------------------------------MLGMIRNSLFG------------------------SVETWPWQVLSTGGKE-DVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPISFAVFPNE-DGSLQKKLKVWFRIPNQFQGSPPTPSDQSVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKV-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R257-1", "uniprot_id": "HEBP1_MOUSE", "id": "Q9R257-1", "name": "Heme-binding protein 1", "aln": "--------------------------------------------------MLGMIRNSLFG------------------------SVETWPWQVLSTGGKE-DVSYEERACEGGKFATVEVTDKPVDEALREAMPKIMKYVGGTNDKGVGMGMTVPVSFALFPNE-DGSLQKKLKVWFRIPNQFQGSPPAPSDESVKIEEREGITVYSTQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVWLVKA-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NRV9-1", "uniprot_id": "HEBP1_HUMAN", "id": "Q9NRV9-1", "name": "Heme-binding protein 1", "aln": "--------------------------------------------------MLGMIKNSLFG------------------------SVETWPWQVLSKGDKE-EVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNE-DGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGT-ATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NAK1-1", "uniprot_id": "A0A8M1NAK1_DANRE", "id": "A0A8M1NAK1-1", "name": "", "aln": "MDSGGCRMNGGGGGLDMISLEDLESVSEEQLELEEPEPEMEEEDLDQGGRLLQYWRDAARGHQVEVPTDMAQPIQQITSNNDGAHTREPVPYTLITRKEKCGEVLYEKRHYEKAHWACITVHEDTYEQSICYGFMKIMRFICQQNSAGSYLGMTIPIVTVVRTDESNTTLSRAVTVAYYLPTPYQNDPPRPYDPDILIEQWPAAIVYSRSFTGATNELSILHELRSLVEALDSP--ALGSDSFIVAGYTNPAAAH-RHNEIWFLERP", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* ::: * : *. *: ::: * :* **:* * .::* : * :.. :::: .: *: :: *. * :***:*: .: .:* : :*.: :.* : :*. :*..** * * .: **: . *** .* * ::* . : . * :*:.. : .* : :** * .: *:**:*::: ", "identical_positions": 46, "similar_positions": 73, "identity": "17.23%" }, { "cls_id": "homologset.agr.HGNC:17177", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8IUI8-1", "uniprot_id": "CRLF3_HUMAN", "id": "Q8IUI8-1", "name": "Cytokine receptor-like factor 3", "aln": "----------MRGAMELEPELLLQEARENVEAAQSYR-------RELGHR-----LEGLREARR------------------------------------------QIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESS---GVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNN---EGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9Z2L7-1", "uniprot_id": "CRLF3_MOUSE", "id": "Q9Z2L7-1", "name": "Cytokine receptor-like factor 3", "aln": "----------MKGAMEPEPEVLLQEARENVEAAQSYR-------RELGQR-----LQGLREAQR------------------------------------------QIKESASQTRDVLKQHFSDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTADDLVREGEIAILGGIEEESDKLWNFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTANHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQTGHSTLVPHEWTTGFEGYSLSSRRNIALRNDAESS---GVLYSSAPTYFCGQTLTFRVETVGQPDRRDSIGVCAERQNGYESLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTSNSH---EGGNAKLRVTISSNNREVVFDWLLEQACGPLYFGCSFFYPGWKVLVF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AEZ7-1", "uniprot_id": "A0A8I6AEZ7_RAT", "id": "A0A8I6AEZ7-1", "name": "Cytokine receptor-like factor 3", "aln": "RVCPPHTPTLHPHTPPPPPASVNQAAAGAGRGGQSRAGRRFRCARPLGVARGSRAQSGIRRAARPDEGRDGAGARGAAAGSPGERGGGAELPAGARPAAAGAAGGAEIKESASQTRDVLKQHFSDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTADDLVREGETAILGGIEEQNDKLWNFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGAVASRPPVQIEELVEKPGGIVVRWCKVDDDFTAQDYRLQFRKCPANPFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQTGHSTLVPHEWTTGFEGYSLSSRRNIALRNDAESA---GVLYSSAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQNGYESLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGPCNNN---EGGNVKLRVTISSSNREVVFDWLLEQSCGSLYFGCSFFYPGWKVLVF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q568M3-1", "uniprot_id": "CRLF3_DANRE", "id": "Q568M3-1", "name": "Cytokine receptor-like factor 3", "aln": "--------------MSIEAEALLQEAKESIEAAQNYR-------SELQQR-----LHGLSQARK------------------------------------------QVRGSASQTRKALQRHFQELQTAVSRLLIDRLNGLLQEVDNIELDSVSPLDDCQKLIEHGVSTADELLREGEAAIRCSINETEDKLGSFTKKALQIQLDSLPEVPSLVDVPCLSAQLDDSLLHMFRAHVARHGSVASHPPVQIEELVERPGGVLVRWCKVDDDFSPQDYRLQFRRSNSSQYEDAYIGKDTEFLVLHLDPHVDHLFRVCARGEGRTEWSPWSIPQTGYTTLAPHEWCPGVDGYILSSRKNIAMRSDSSAPGHGGVLYSNSPTYFCGQTLTFKITAAGQTDKRDSLGVCADSRTDTDSLQRDQAVCISTNGAVFVNGKEMTNQLPAITVGSSVTFDMEVVSLFPVNNNNPSDGGNFKLRVTIGSGNREVVFDWLLDQVLDSLFFGCSFTHPGWKVLVF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : * * ...*. * *: .* : ::: ******..*::**.:*: ::.:** :** ******.** :::.*************.**::*:**** *: .: * .:** .***** :********** **************:*::.: *: :**:***:********:*:***::**********:.********:. :. :**.*:*.:***:***:**:**: *******:** ******:** *::**.**** .*.:** ****:***:*.*:.:. ***** :***********:: :.**.*:***:****: : . :*****************************:* **:****:*.*:* . ..: :**: ******.*.**********:* ..*:***** :********", "identical_positions": 267, "similar_positions": 113, "identity": "52.15%" }, { "cls_id": "homologset.agr.HGNC:17178", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P59511-1", "uniprot_id": "ATS20_MOUSE", "id": "P59511-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 20", "aln": "MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVTPTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPFRTHYRISAYGQLFQLNLSADAAFLAAGYTEVHLGTPVPGPGGRSTESPDLRHCFYRGQVNAREDHTAVFSLCGGLMGTFKANDGEYFLEPVLRADGSAHDDDHNKPHLIYRQELKRNSFAR--SHKPCEVSENQMEKTALPSQSSRNTTGDVDIEEEAVFRLEGE-----RSQLHSRNKRFLSYPRYVEVMVTADAKMVHHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVVIHSEQEGPVISFNAATTLRNFCLWQQSQNVPDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKEAGIKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFGPGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQG--AVFEYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNMDCELRWHIIGKSDCSSQCGQGYRTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVLTRWHYSEWSQCSRSCGGGDKTRESYCVNGFGHRLAESECRELPRVVLENCNEFPCPSWATSEWSECPVTCGKGMKQRQVWCQLSEDPMRDGFCNASTKPESLRPCELRACASWHVGPWGSCTATCGHGYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPLGRAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSPCGEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECSLAACPPLYSRAPSSSEQPSHVPSRNVPLTHKPGENQDQGAQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCDGSSKPPESRHCGSGPCPHWNYGDWGECTQTCGGGVKSRFVICQFPNGQMTQEHSCELP-KPPSMMQCHLHACPEDVSWYRGPWKSCSASCGKGVKYREVLCIDQFQRKLEEKYCSHLHKPRTHKACRSGRCPSWKANKWKECSVTCGSGVQQREVYCRLRGTGRVSEDMCDPSTRPQGQRQCWRQDCMRYQWTTGDWLDCSTSCKKKETYRLVKCVNEQNVQANESLCDPLTKPLSIKKCRNPHCKYSVVTGDSSQCAGNCGFTSPQKITYCTKIQSSKKHTFH-QLRPVVYGECPVIPSPQAYKCDLRSCLHVATWKVGKWSKCSVTCGIGIMERRVACRTENGWPSDLCLKRLKPDAQKKCYANDCKLLTTCKELQVTNNVTKDGDYDLNVRGRILKIHCSGMQLENPREYLPLVKSEDNFSEIYGLRLQNPYECPFNGSRRPDCACENDYLPAGYTVFSKVRVDLESMQIKTADLLFSQTLSGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKISNTAKWLAQGRYASVIIHRSQDGTKVYGRCGGFCGKCIPHMATGLSIQVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2K836-1", "uniprot_id": "A0A0G2K836_RAT", "id": "A0A0G2K836-1", "name": "", "aln": "MRVAKWLTGLLCPISLLLTGSWEVRFHPRQEALVKTLASYEVVTPTRVNEFGDVFPQNRHFSRKKRSSGVPEPPPLRTHYRISAYGQLFQLNLSADSAFLAAGYTEVHLGTPVPGPGGRSAEPPDLRHCFYRGQVNAREDHIAVFSLCGGLMGTFKANDGEYFLEPVLKADGSEHEDDHNKPHLIYRQEVKRNAFVRSQSHGPCGVSENQTEKTALPSPSFRNTTGDLNRRKGAVFGLEGE-----RSRLHSRSKRFLSYPRYVEVMVTADAKMVRHHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLVIIHSEQEGPVISFNAATTLRNFCLWQQSQNVLDDAHPSHHDTAVLITREDICGAKEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNVPHDDSFKCKESGTKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNKQCELMFGPGSQVCPYLKQCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDISGLPPNVRWLPKYSGIAVKDRCKLYCRVAGTTSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSAHYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQG--AVFEYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVHYIFNIPIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACIRKSDRAVVSDQSCSHLPLPLFVTERCNTDCELRWHITGKSDCSSQCGQGYRTLDVHCMKYSVHKGQTVPVGDQYCGDQLKPPNREPCHGSCVLTRWHYSEWSQCSRSCGGGEKTRESYCVNGFGHRLAERECQELPRVVLGNCNDFPCPGWATSEWSECPVTCGKGMKQRQVWCQRSEDPVGDDFCDASTKPESLGPCELRACASWHVGPWGSCTVTCGHGYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPCLAILKVGATSLPAIPLGKAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDGVADELNCAHLPRPAEVSLCFSPCGEWQAGDWSPCSASCGHGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECRLAACPPSYSRSPSSSEQPSHGPGRNVPLTHKPEENPDQGVQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCEATSKPPESKHCGSGPCPQWNYGDWGECTQTCGAGVKSRFVICQFPDGQMAQEHSCELP-KPPSMMQCHLRACPDDVSWYRGSWKSCSASCGKGIKYREVLCIDQVQRKLEEKYCSHLHKPRTHKPCRSGRCPSWKANKWKECSVTCGSGVQQREVYCRLRGTGRVAEDMCEPSTRPQVQRPCWHQDCTRYQWTTGDWLDCSTSCKKKETYRLVKCVNERNMQVNESLCDPLTKPVSIKKCRNSHCKYMVVTGDSSQCAGNCGLTYSQRITYCTRIQPPKKNAFHHQLRPVNYGQCPVIPSPQVYKCDIRSCLRGATWKVGKWSKCSVTCGNGIMERRVACRTENGWPSDLCLKRLKPDAQKKCYANDCKLLTTCKEIQVTNNITKDGNYDLNVRGRILKIHCSGMQLENPREYLPLVKVEDNFSEIYGLRLQNPYECPFNGSRRADCACENDYPPAGYTVFSKVRVDLASMQIKTTDLLFSRTLFGKAVPFATAGDCYSAARCPQGQFSINLAGTGMKVSSTAKWLAQGRYASVIIHRSQDGTKVYGRCGGFCGKCVPHVSTGLPIQVL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59510-1", "uniprot_id": "ATS20_HUMAN", "id": "P59510-1", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 20", "aln": "MWVAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLN-NSFLQ--TLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVT-KYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQP-DDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKEILIEVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLH-RLRPIVYQECPVVPSSQVYQC-INSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRKDGDYYLNIKGRIIKIYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDNGHLAAGYTVFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQGQFSINLSGTGMKISSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPIQVI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* ********* :**::* **** *********:**:***** * ******:****.:****:**** . ** *:*****::**********:**::************** *. .: ..************::**: **.****** ****.::*******:::***. ::*.**********::: *:* : : * ***.* ::*:** : * . *:: : *: .: .: ***.**::*****:*:*******:* **.***:*:********:****.******:**:****:** *:*****.*:.****:*** ***:** **.*****************.:****: ***: ***:*** :** *.**:** :**********.:.* ***. :*** . :******:*.:* ***:** **:*::*******:********: . *:*..:**** ****:**** ******:**::: * :*****:* :**** ***:* ****.*******::****.:: *****:****** *************.*::* *:********.********************.:**********:***:**.*:*.******:****..********:****. ** *** * *********:****** * *********.** *************:*::*****:****************::* *:****:* **.******::****:****::* :*****:** :*:*******::******:* * *::::************:* ****:****::*:*******:.********:**:*:*::***::****:.*.***:* ***: ** *******: ***:*************:******:*:**:* *.*:*********.:* ***.**:******************:::*****:*.******: **:**.**. ***:*.**.**:****** ****** ******** . * : *.**::******* ****::****:*****.**.*******:* ***:.*: .::*:* ** .********.*:::** * :: :: **:: : : ******************:********** * :*** ******** : **:************************:***:**** :**.***** **: **** ****** :*: ***. ***: . *:***:* :* :* .: *:***********:** **:*************:*:**: *:.:***** ::**.****:****:****:****.*:***:******:**: ::*.**: ****::***::*** ****:: .*.********* *****:****.*****:. **:::** ***.*** ********.*:*************:*****:*.*:* *:**: **** ** ** *** ::: . *:*****::*:::: ::*.::: *.** : :. * .:: *:***. *:* ***.******.***:: *:*****.* ..**: :* :***: * :***:**.*.*:* :.***: **************** ***:*:* * *::* .*****::***.*********** :*****:**.*:: ***:* **::***:**:*:.* ****:***.**: *:****:**:**:***:******** ** *:*.: .********:*:** ******:*****:*: *:************* ***********:*****:*.*****:** *:** *:**:***:.:*:***:****:**::***.***:", "identical_positions": 1301, "similar_positions": 411, "identity": "67.87%" }, { "cls_id": "homologset.agr.HGNC:17179", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CZP7-1", "uniprot_id": "CD37L_MOUSE", "id": "Q9CZP7-1", "name": "Hsp90 co-chaperone Cdc37-like 1", "aln": "MEQPWPPPGPWSFPRTGGETEEESD-LDVSPSSSHYSPVPDGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLA----------------------------------------LHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQRERMCLWNMDAISKD------------VFNKSFINQDKRK-----------------------TEEEDKSQSFMQKYE------QKIRHFG--MLSRWDDSQRFLSDHPHLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAKNCNV------DPRGCFRLFFQKAKAEE------EGYFEAFKNELEAFKSRVRLYAQS---QSLQPVTVQN-------------------HVPHSGVGCIGSLES-LPQNPD-------------------------SLQCCTPAPLCSVDSVVHK----EDDD-RMMDTV-----------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5XIC3-1", "uniprot_id": "CD37L_RAT", "id": "Q5XIC3-1", "name": "Hsp90 co-chaperone Cdc37-like 1", "aln": "MEQPWPPPGPWSFPRTGGETEEESD-LDVSPSSSHYSPVPDGGAQMYSHGIELACQRQKEFVKSSVACKWNLAEAQQKLGSLA----------------------------------------LHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQRERTCLWNVDAISKD------------VFNKSFINQDKRK-----------------------TEDEDKSQSFMQKYE------QKIRHFG--MLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAKNCNV------DPRGCFRLFFQKAKAEE------EGYFEAFKNELEAFKARVRLYAQS---QSFAPVTVEN-------------------HAPHSGVGCIGSAEP-LPQNPD-------------------------SLQCCPPAPLCSVDSVVHK----EDDD-RMMDTV-----------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7L3B6-1", "uniprot_id": "CD37L_HUMAN", "id": "Q7L3B6-1", "name": "Hsp90 co-chaperone Cdc37-like 1", "aln": "MEQPWPPPGPWSLPRAEGEAEEESD-FDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLA----------------------------------------LHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKD------------VFNKSFINQDKRKD----------------------TEDEDKSESFMQKYE------QKIRHFG--MLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNV------DPRGCFRLFFQKAKAEE------EGYFEAFKNELEAFKSRVRLYSQS---QSFQPMTVQN-------------------HVPHSGVGSIGLLES-LPQNPD-------------------------YLQYSISTALCSLNSVVHK----EDDEPKMMDTV-----------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A7YY97-1", "uniprot_id": "CD37L_DANRE", "id": "A7YY97-1", "name": "Hsp90 co-chaperone Cdc37-like 1", "aln": "--------------------------------------------------MASLCQRQQHCVKASIASEWQLAEAQDQLCGLE----------------------------------------LHSSESVEQERARALASSTELSHTEHQWRLKERMLG---TLCP----EANRD------------VFDKSIINITQSWPN---------------------ESDPDKSLNFVQRNE------ELLKHFG--MLGRWDDSQRFLAEYHHLICEETANYLILWCFRLQAEKKEALMEQVAHQAVVMQFILEMARNTQQ------DPRGCFRHFFQKAKAGQ------EGYLDVFHTELQAFKDRVKEYTMKSTGETPKDTVHQN-------------------TPPACCLDPKEVFES-LPQELKTCIQMQDMQILQNVLSSMNPQVAEYHVKRCLEAGLWTNIPRTSKDESSEVDEWKMMET------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q24276-1", "uniprot_id": "CDC37_DROME", "id": "Q24276-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "----------MVDYSKWKNIEISDD-EDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERISKKD----------------------------------------GDE-EALKKELEKIEAEGKELDRIESEMIKKE-------KKTPWNVDTISKP------------GFEKTVINKKAGRKPDENLS---------------EEEREQRMKQFVKENE------KLCQQYG--MLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDV------DPRACVSSFFSKIQHCH------PEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKE----------------RLGPGGLDPADVFES-LPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSDDVAGGEEKTDDAKSESAAKEEPIYTGVSTEDVD-------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P06101-1", "uniprot_id": "CDC37_YEAST", "id": "P06101-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "---------MAIDYSKWDKIELSDDSDVEVHPNVDKKSFIKWKQQSIHEQRFKRNQDIKNLETQVDMYSHLNKRVDRILSNLPESSLTDLPAVTKFLNANFDKMEKSKGENVDPEIATYNEMVEDLFEQLAKDLDKEGKDSKSPSLIRDAILKHRAKIDSVTVEAKKKLDELYKEKNAHISSEDIHTGFDSSFMNKQKGGAKPLEATPSEALSSAAESNILNKLAKSSVPQTFIDFKDDPMKLAKETEEFGKISINEYSKSQKFLLEHLPIISEQQKDALMMKAFEYQLHGDDKMTLQVIHQSELMAYIKEIYDMKKIPYLNPMELSNVINMFFEKVIFNKDKPMGKESFLRSVQEKFLHIQKRSKILQQEEMDESNAEGVETIQLKSLDDSTELEVNLPDFNSKDPEEMKKVKVFKTLIPEKMQEAIMTKNLDNINKVFEDIPIEEAEKLLEVFNDIDIIGIKAILEN----EKDFQSLKDQYEQDHEDATMENLSLNDRDGGGDNHEEVKHTADTVD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .. . . .. : . * : :: : .. . :. : *:.:.:* . *:. : : ..:* : .:..*::** :: :: *: . *:: .:. : . . : :: **. * :* *: . : . **.* . : .. :: :: * : . :: : :. :*:: . :: : . : * * ", "identical_positions": 22, "similar_positions": 87, "identity": "4.24%" }, { "cls_id": "homologset.agr.HGNC:1718", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6GQT0-1", "uniprot_id": "CC14A_MOUSE", "id": "Q6GQT0-1", "name": "Dual specificity protein phosphatase CDC14A", "aln": "----------------MAAESGELIGACEFMKDRLYFATLRN--RPKSTINIHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLK---------------SYSLSRKKIVHYTSFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFDFETFDAEEYEHYERVENGDFNWIVPGKFLAFSGPHPKSK-----IENGYPLHAPEAYFPYFKKNNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEG---AIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLKEKQ----ASLWVQGDIFR----------------------------------------------------------------------------------------------------------------------SKLKNRPSSEGSITKIIST-----------LDDMSIGANLSKLQSTERIGENNFE---------------------DEDMEIKNNVTQGDKLRALKSQRHPRS----SPSCAFRSDDMKGHQRAMAQTFR---LSSSPQPTMSTMKTSKVCLSP---------SVTAKKISR-------GSLSSGANIRSFSINSRLASSLGNLNAGTEEPE---------------------------------------------------------------------------------------------------------------------------------------------------TKKTTSLTKAAFIASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSNSSSSSSGLGGN------------------------------------------LN-SSPVPQSAKPEEHT----TILRPSFPGSLSSSSVR-----------------FLSR----------------------SIPSLQSEYVHY------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6B415-1", "uniprot_id": "A0A8I6B415_RAT", "id": "A0A8I6B415-1", "name": "", "aln": "----------------MAAESGELIGACEFMKDRLYFATLRN--RPKSTINIHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKPKKMFKNVPFLRKLESYSLSRKKIVHYTSFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFDFETFDADEYEHYERVENGDFNWIVPGKFLAFSGPHPKSK-----IENGYPLHAPEAYFPYFKKNNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEG---AIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQ----ASLWVQGDIFR----------------------------------------------------------------------------------------------------------------------SKLKNRPSSEGSITKIISS-----------LDDMSIAGNLSKLQSTERIGENNFE---------------------DEDMEIKNNVTQGDKLRALKSQRQPRS----SPSCAFRSDDMKGHQRAVAQTFR---LSSSPQPTVPTVKTPKVCLSP---------SVTAKRISR-------GSLSSGANIRSFSINSRLASSLGNLNSGTEETE---------------------------------------------------------------------------------------------------------------------------------------------------NKKTTSPIKAAFIASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSSSGGS---LGGN------------------------------------------LN-SSP---SAKPEEHN----TILRPSFSGALSSSSVR-----------------FLSR----------------------SIPSLQSEYVHY------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UNH5-1", "uniprot_id": "CC14A_HUMAN", "id": "Q9UNH5-1", "name": "Dual specificity protein phosphatase CDC14A", "aln": "----------------MAAESGELIGACEFMKDRLYFATLRN--RPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLK---------------SYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSK-----IENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEG---AIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQ----ASLWVQGDIFR----------------------------------------------------------------------------------------------------------------------SKLKNRPSSEGSINKILSG-----------LDDMSIGGNLSKTQNMERFGEDNLE---------------------DDDVEMKNGITQGDKLRALKSQRQPRT----SPSCAFRSDDTKGHPRAVSQPFR---LSSSLQGSAVTLKTSKMALSP---------SATAKRINR-------TSLSSGATVRSFSINSRLASSLGNLNAATDDPE---------------------------------------------------------------------------------------------------------------------------------------------------NKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSN--------GGN------------------------------------------LN-SPPGPHSAKTEEHT----TILRPSYTG-LSSSSAR-----------------FLSR----------------------SIPSLQSEYVHY------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IVA4-1", "uniprot_id": "CC14A_DANRE", "id": "A0A0R4IVA4-1", "name": "Dual specificity protein phosphatase CDC14AB", "aln": "MTLDNLKHSAILSTLFKMADDNDLLGASEFIKDRLYFATLRS--KPKSTANTHYFSTDEEFVYENFYADFGPLNLAMLYRYCCKLNKKLK---------------SFTLTRKRIVHYTSFDQRKRANAAVLIGAYAVIYLKKTPEEAYRALISGSNASYLPFRDASFGNCTYNLTVLDCLQGIRKALQHGFLNFETFDVNEYEHYERVENGDLNWITPGKLLAFSGPHPKSK-----VENGYPLHAPEAYFPYFRKHNVTTIVRLNKKIYDAKRFTDAGFDHYDLFFVDGSTPSDIITRRFLHICESTSG---AVAVHCKAGLGRTGTLIGCYLMKHYRFTSAEAIAWIRICRPGSIIGPQQHYLEEKQ----ASLWAHGDSLR----------------------------------------------------------------------------------------------------------------------SKQ--RQYQDRSVPQLISS-----------MDNLSISTSIFKSHSLDRMEENDYA---------------------ENDLGMT----QGDKLRALKGRRQPRS----ATTGAIRVEDVKVHTRSPSQPLSRMKPPASSQGSISPLKSSKVPASSSSSSSSSSVSASAKRIGR-------SSSSS-TNLKS----TRLASSLGNLYEPNTESI---------------------------------------------------------------------------------------------------------------------------------------------------SSGK-PPSPSSFTPHPVRTTYNYHYEVNN------NNNQYSTTSSPSKS-----LGYN------------------------------------------LNHSGPSGASANARLSAGE--QGHQRNPPAGLSGLSTR-----------------HLSR----------------------SIPSLQSEYVQY------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLW7-1", "uniprot_id": "Q9VLW7_DROME", "id": "Q9VLW7-1", "name": "", "aln": "--------------MLDDDNSDLLVCASEMQEDRLYFVAFKKNIKPKNTVNTHYFSVDEEFIYENFYNDFGPLNICMLYRYCMKLNTKLN---------------AKCHANKKIVHYTSMNPAKRLNAAYLIGSYAIIYLNKTPQEAYRPLVAGEIPAYTRFCDASYGPSNFKISLLDCLNAVHKGLQAGFFNFNDFDAEEYEYFERVENGDFNWIVPQKFIAFCGPHQKSKT----LPNGYPCHAPERYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPSDAIMKKFLSICETTKG---AIAVHCKAGLGRTGSLIGAYIMKHYGFTALEAIAWLRLCRPGSVIGHQQQWMEDKQ----SWLWSEGERMRRRTSLPILQHTYGINSLELKKKLASAAADSTEHVDLLLTRVKGISQRVDTMHLNDQDNLDAACTDQTDEELSEQLRLERDERALYQSVEDPNCNNSDDNDTDTISAPADPPPTSSYTISTRRRKSPSGANKPTVIATSLRRLVNPNANRSGLSTASGVYPTPELASCTEKKLRKPSANVFEAARHTIASTVRMTQTALEKKQAQTQGDKLNQIKALRRHHSRSVNVNSNSSEQESNVRHTRARSQPFRNNNNGVGGNTAMAALKPTSSCLPTGTG----TAALLANNLNNNNDCGIGTSGSSNNNHNNNNNNSNLSNSLNNYNNNNNTTNNILASSGSSRTRSLALYSKRMELKHLRKAEQQQQQQVQQEQPLLPVEKQLLRQYATINESKIPVVSGGGGGAGSSATIPPTRGSAARTSHHHMTLRGRSRIRYQRPNAGETAPAAAQTQPCTVATARYYRDVSAIPTIGVFGGGPGGSSSTSASFNIATRSASATLDLNSNPLPKTTKLTSLNNNPTTTPPPSSNPADTSRLSGRGSAELQAIIEHGLVAGSAKRNKRSLSSTRLDKDKSDEYNTKLLRKTAAAAAAAATAASAVANSTSINATHATNASTTSSMNNNCKYNSCSSSNSGSFKLSRRLFGESGSSASTSASNSGIPTPTAPPSSSQWQQHLVRGVSRASSEKDRDRERQQQQQQQSLDHQQSNLKLRKKISY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q00684-1", "uniprot_id": "CDC14_YEAST", "id": "Q00684-1", "name": "Tyrosine-protein phosphatase CDC14", "aln": "-----------------MRRSVYLDNTIEFLRGRVYLGAYDY--TPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILN---------------DPENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVD-PPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTP-DFIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDFREWKYTTR---------------------------------------------------------------------------------------------------------------------------------------------------------ISLKPSEAIGGLYPLISLEEYRLQ---------------------KKKLKDDKRVAQNNIEGELRDLTMTPP----------SNGHGALSARNSSQPSTANNGSNSFKSSAVPQTSPGQPRKG----------------------------------------QNGSNTIEDINNNRNPTS-------------------------------------------------------------------------------------------------------------------------------------------------------HANRKVVIESNNSDDESMQDTNGTSNHYPKVSRKKNDISSASSSR---------------------------------------------------MEDNEPSATNINNAADD----TILRQLLPKNRRVTSGRR----------------TTSAAG--------------------GIRKISGSIKK-------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * : *: ..*:*: : *:.* : :*: :: :.*:.*: ****:*: :**:. :: *: :.* :*.*:. . :* *** :: .* :: **.:. :.* . ..: * **.:. . ::::: * : .: :. : *::::. *: :.** :*:** **:* :.* .::**..*: . ..: :. : : :* .:** ::*** ::*. . * : *::* **:* **: *. * :.*: .*. :************ **..::: * ** * *.::*: *** ::* **::: :* : .:. . : * . : *.: :: . * :*. . : : . ... . :.:: : . . . ..: .. .. :. . . . . * * ... : ", "identical_positions": 98, "similar_positions": 176, "identity": "8.94%" }, { "cls_id": "homologset.agr.HGNC:17180", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D1A4-1", "uniprot_id": "ASB5_MOUSE", "id": "Q9D1A4-1", "name": "Ankyrin repeat and SOCS box protein 5", "aln": "-MSVLEESRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVSQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACARTLLEAGANANAITIDGVTPLFNACSQGSASCAELLLEYGAKAQLESCF-PSPTHEAASKGHHECLDILIAWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVHKGKYWDTPLHAAAQQPSTEIVNLLLEFGADINAKNTDLLRPVDLATSNSAVERILLQHEATPSSLCQLCRLCIRNYIGRQRFHLIPQLQLPTLLQNFLQYR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8J8XZ77-1", "uniprot_id": "A0A8J8XZ77_RAT", "id": "A0A8J8XZ77-1", "name": "", "aln": "-MSVLEESRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVSQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACARTLLEAGANANAITIDGVTPLFNACSQGSASCAELLLEYGAKAQLESCF-PSPTHEAASKGHHECLNVLIAWGVDIDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVHKGKYWDTPLHAAAQQPSTEIVNLLIEFGADINAKNTELLRPVDLVTSNSAVERILLQHEATPSSLCQLCRLCIRNYIGRQRLHLIPQMQLPTLLQNFLQYR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WWX0-1", "uniprot_id": "ASB5_HUMAN", "id": "Q8WWX0-1", "name": "Ankyrin repeat and SOCS box protein 5", "aln": "-MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B5Y2-1", "uniprot_id": "A0ACD6B5Y2_DANRE", "id": "A0ACD6B5Y2-1", "name": "", "aln": "MTESTEEYRPFAAQLSNVYLTILSLFCFKLFVRITLNLLTHFYIIKGNRKEAARISAEFYDNGQGHGSWADRSALHDAASQGRLLALKTLIAQGHSVNVLTIDHISPLHEACIGGHVACARALVDAGANVNVTAIDGVTPLFRACSAGSLACLELLLQSDARPQALAIFQPSPIHEAASRGHSKCVEMLVSWGVDVDFEIPHMGTPLYTACRCKEFLCARKLLDGGANVQRGSYMETPLHAASQKDCLSIVKLLLEFGADVNARNLQYKRAVEVAPPGSLTEGFLLIYEATPRSLSQLCRQQIRERLGRSRLHLLPHLPLPKAMKNFLQYR", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . ** **** ******:************:*:* :*:****:**********:****. **:*******.**:**********:**::**:.**.:*:**::******:*.******:*::****.*. :********.*** ** :* ****: .*:.* : : *** *****:** :*:::*::**:*:* :***:*****.** .::* * *** .**:*::*.* :******:*: . .**:**:*****:**:* : *.:::....* .* :** :**** ** **** **. :*: *:**:*:: **. ::******", "identical_positions": 199, "similar_positions": 89, "identity": "60.12%" }, { "cls_id": "homologset.agr.HGNC:17181", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6ANG1-1", "uniprot_id": "A0A8I6ANG1_RAT", "id": "A0A8I6ANG1-1", "name": "", "aln": "MPFLHGFRRIIFEYQPLVDAILGALGIQDLERQEPLD--DYASSEESRILVLTELLEQKAHSPFYQEGVSNALLKMAELGLTRAAAVLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKNG-----------------------------ADVKATTKDGDTVFTCIIFLLGETVCGDKEEAPMINRFCFQVTQLLLAHGADPSECPAH-------ESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFNLIFERLCSHP-GCAEDDSHVELLHKAETVLDLMVTSSQRLQ--LPEN-FNIHPVGGLAGKIQALHASLRQLESYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLLSAHS-SPEDTC----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZU1-1", "uniprot_id": "ASB6_MOUSE", "id": "Q91ZU1-1", "name": "Ankyrin repeat and SOCS box protein 6", "aln": "MPFLHGFRRIIFEYQPLVDAILGALGIQDLERQEPLD--DSASSEESRILVLTELLEQKAHSPFYQEGVSNALLKMAELGLTRAAAVLLQSGANLNFEDPVTYYTALHIAVLRNQPDMVELLVRHGADINRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKNGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVCGDKEEAPMINRFCFQVTQLLLAHGADPSECPAH-------ESLTHICLKSFKLHFPLLCFLLESGAAYNCSLHGASCWSGFNLVFERLCSHP-GCAEDDSHIELLHKAETVLDLMVTSSQRLQ--LPEN-LNIHPVGSLAGKIQALHASLRQLESYPPPLKHLCRVSIRLCLRPWPVDTKVKALPLPDRLKWYLLSAHS-DTQDTC----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NWX5-1", "uniprot_id": "ASB6_HUMAN", "id": "Q9NWX5-1", "name": "Ankyrin repeat and SOCS box protein 6", "aln": "MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAH-------ESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHP-GCTEDESHADLLRKAETVLDLMVTNSQKLQ--LPEN-FDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BE57-1", "uniprot_id": "A0A8M2BE57_DANRE", "id": "A0A8M2BE57-1", "name": "", "aln": "MPFLHGFRRIVYEYQPLVDAVLCVLGT-DGENQRRQD------EEESVSVALAELLDREAQSPVFMQGISYSLFRVAEFGLVSAAQVLLRYGADLNFEDPVSYYNPLHIAVLRNKPDMVRMLISSGADIDKRDRIHESSPIDLASEEADKLPCLRVLLDFGADVNAKDKNGKTALLHALASSDGLTVKNMDNIQLLLERGADVNATTQDGETPMSSLAFLVKEALESSVEDAKEIGHFCTHVAHLLISHGAGPSCCLSATDGEVWEHSLTYTSLENFDLLFPLTVLLLQHSASFVCSHHSASYWTGPQLIFTRLAEALREAVDAAEVADVLAKAEVLLDLARICSPAIPPLFPRSQLPVLEQGSIHEPLLELYGKLEERESQPMPLRCLCRRLIRNCLLPWPFEEKVKALPLPDRLKDLLLPENSWKNRAGWDRFKPRGSSH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**********::********:* ** * *.*. * .*** :.*:***:::*:**.: :*:* :*:::**:**. ** ***: **:*******:**..********:****.:*: ***:::*********:******.::****: ***:****** **:* ***:***:**:* ::.: **: *:: .. *:* *.:** :*::**::***.** * : .***: .*:.*.* *** :**: .*:: ** *.** *:* :::* **.. ..: . ::* ***.:*** * : :*.. : : *.: : *: .*.: ** * **: *** ** * ***.: ************ **. :* . . ", "identical_positions": 194, "similar_positions": 110, "identity": "43.89%" }, { "cls_id": "homologset.agr.HGNC:17182", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZU0-1", "uniprot_id": "ASB7_MOUSE", "id": "Q91ZU0-1", "name": "Ankyrin repeat and SOCS box protein 7", "aln": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTRQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H672-1", "uniprot_id": "ASB7_HUMAN", "id": "Q9H672-1", "name": "Ankyrin repeat and SOCS box protein 7", "aln": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZVT6-1", "uniprot_id": "D3ZVT6_RAT", "id": "D3ZVT6-1", "name": "Ankyrin repeat and SOCS box protein 7", "aln": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTNSVSPLGLGRRLSCSVCP----ASMETSISLDKQHPDKAGHGSVLL", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**********************************************************************************************************************************************************************:*****.************************************************************************************************:**.. * *:. * .: .:.: * * * :", "identical_positions": 275, "similar_positions": 14, "identity": "86.48%" }, { "cls_id": "homologset.agr.HGNC:17183", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZT9-1", "uniprot_id": "ASB8_MOUSE", "id": "Q91ZT9-1", "name": "Ankyrin repeat and SOCS box protein 8", "aln": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAERDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPVSLKDYLLLLE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LDV0-1", "uniprot_id": "A0ABK0LDV0_RAT", "id": "A0ABK0LDV0-1", "name": "Ankyrin repeat and SOCS box protein 8", "aln": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H765-1", "uniprot_id": "ASB8_HUMAN", "id": "Q9H765-1", "name": "Ankyrin repeat and SOCS box protein 8", "aln": "MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***********************************************************************************************:************************************************************************************** *********************************:******* *****::* *******************************************.***:******", "identical_positions": 279, "similar_positions": 6, "identity": "96.88%" }, { "cls_id": "homologset.agr.HGNC:17184", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96DX5-1", "uniprot_id": "ASB9_HUMAN", "id": "Q96DX5-1", "name": "Ankyrin repeat and SOCS box protein 9", "aln": "------------MDGKQGGMDGSKPAGPRDFPGIR--------------------------------------LLSNPLMG---DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKL-VLPEDLKQFLLHL------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q91ZT8-1", "uniprot_id": "ASB9_MOUSE", "id": "Q91ZT8-1", "name": "Ankyrin repeat and SOCS box protein 9", "aln": "------------MDGEQRGRS-DRPGGSPHLP-----------------------------------------FLSNPLMG---DVVSDWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPHPETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVNQGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDLVPLESPLIQIFLQNEGPQSLRQLCRLRIRKCFGIRQHHKISEL-LLPEDLKRFLLHL------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZSR2-1", "uniprot_id": "A0A8I5ZSR2_RAT", "id": "A0A8I5ZSR2-1", "name": "Ankyrin repeat and SOCS box protein 11", "aln": "MSYDANYNSVKIFSRRNLCREEAKMEDGPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDHGRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHEGPPALSQLCRLCVRKCLGRTCHQAIYALDCLDQDVCSSTNHRAGISQGHQKHGI", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. .: . : . : ::: : * * :* **:*:** :* *:*:.**:** **::* ::**.****** **::*.. **.:**:***:* . ******* *** ***:**:.**. : * ********.:**: :*:: * * . **: :*.:******:** *: *.***** *..*::*: *:***..** :* *: ** ::**: : :*::** .::*.. :*.: * :* .*** :* ***** :***:* *: * * * :*: * ", "identical_positions": 127, "similar_positions": 86, "identity": "35.28%" }, { "cls_id": "homologset.agr.HGNC:17185", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8J8YAH4-1", "uniprot_id": "A0A8J8YAH4_RAT", "id": "A0A8J8YAH4-1", "name": "Ankyrin repeat and SOCS box protein 10", "aln": "TLMSWSPEECRDQGEPQGNRYSLCARLVEKPDRAPEENPEPGLGPIIVRKASGPALAFWQAVLVGDVGSVSQILSDSSTGLAPDSTFDTSDPERWRDYRFNIRALRLWSLTFEEELTTPLHVAASRGHTEVLQLLLRRRAKPDSAPGGRTALHEACAAGHAACVHVLLVAGADPNTPDQDGKRPLHLCRGPGILECVELLLKFGAQVDGRSEDEEETPLHVAARLGHVELADLLLRWGACPHVRNSEGWTPLLTACDARCQSPVDAEATANRCFQLCSLLLSVGADADAANQDKQRPLHLACRHGHSAVVQLLLSCGVSANAMDYGGHTPLHCALLGPTTALAHSPEHIVRDLLNYGAVRVWPGALPKVLDRWCMSPRTIEVLMNTYRVVQLPEEAKGLVPPEILQKHCGFYSSLFALVKQPRSLQHLCRWALRTHLEGRLPHALPRLPLPPRMLRYLQLDFEDLLY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZT7-1", "uniprot_id": "ASB10_MOUSE", "id": "Q91ZT7-1", "name": "Ankyrin repeat and SOCS box protein 10", "aln": "MLMSWSPEECRDQGEPQGDRYSLCAKLVEKPDRGSEEHLEPGLGPIIIRSASGPTLAFWQAVLVGDVGSVSRILSDSSTGLAPDSIFDTSDPERWRDYRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLELLLRRRAKPDSAPGGRTALHEACSAGHAACVRVLLVAGADPNTLDQDGKRPLHLCRGPGILECVELLLKFGAQVDGRTEDEEETPLHIAARLGHVELADLLLRWGACPDVRNSEGWTPLLAACDIRCQSPKDAEATTNRCFQLCRLLLSVGADADAANQDKQRPLHLACRHGHSAVVQLLLSCGVNANAMDYGGHTPLHCALLGPTTAVAHSPEHTVRDLLNHGAVRVWPGALPKVLDRWCMSPRTIEVLMNTYRVVQLPEEAKGLVPPEILQKYHGFYSSLFALVRQPRSLQHLCRCALRSHLEGCLPHALPRLPLPPRMLRFLQLDFEDLLY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WXI3-1", "uniprot_id": "ASB10_HUMAN", "id": "Q8WXI3-1", "name": "Ankyrin repeat and SOCS box protein 10", "aln": "MLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *********:.**** .:*:.***:*****.*..**: :.* ***: *.****:********.****.**:**:********** ***********:*************:********************.*******:***************:***:***:********** *************** ***.****:***:****:*:*******:*************** ****..**:*******:*** **** *****: **:*** ****.*******:************:**:***:*******.**:************* **::*:*:**** ** ***:**************:**. .*********** ******** ***.** ***: *********:********.* ***:**** **:**********:**:******.:**", "identical_positions": 377, "similar_positions": 64, "identity": "80.73%" }, { "cls_id": "homologset.agr.HGNC:17186", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZSR2-1", "uniprot_id": "A0A8I5ZSR2_RAT", "id": "A0A8I5ZSR2-1", "name": "Ankyrin repeat and SOCS box protein 11", "aln": "MSYDANYNSVKIFSRRNLCREEAKMEDGPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDHGRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHEGPPALSQLCRLCVRKCLGRTCHQAIYALDCLDQDVCSSTNHRAGISQGHQKHGI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQ31-1", "uniprot_id": "ASB11_MOUSE", "id": "Q9CQ31-1", "name": "Ankyrin repeat and SOCS box protein 11", "aln": "------------------------MEDAPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLHEGPPALSQLCRLCVRKCLGRTCHHAIYALG------LPESLEKFLLYQ-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WXH4-1", "uniprot_id": "ASB11_HUMAN", "id": "Q8WXH4-1", "name": "Ankyrin repeat and SOCS box protein 11", "aln": "------------------------MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLH------LPEPLERFLLYQ-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q70X92-1", "uniprot_id": "ASB11_DANRE", "id": "Q70X92-1", "name": "Ankyrin repeat and SOCS box protein 11", "aln": "---------------------------MAVVHAEGNVWIKQWD----------------HRFHMYGG------QTCSPLMAGS---WDDRTPLHDAALQGRLLPLRRLLSQGYNVGMATLDGITALHEACVGGHFTCAKLLLEHGADANAVTFDGATPLFSACCSGNPALVSLILTHSSAHHPAHLLCSPLHEAAKRGHTACVELLLSHGVNVDMELPSVGTALYCACEVKSTDCVLTLLILGADVQCGRGLDTPLHAACRVGGAKEAELLLEHGADRTSRNSEGKTPLDLTSDQS--IKHLLQTAGTCSLSQLCRWCIRRSLGQKGLNKTKTLC------LPHMLHNYLLYH-------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ...:. *:::. : :*:: * : .. : .* * **:***:** *****.*: *::** **.:.*:: :::*****:***.:*** ***:**..*. *..******.*****..* *.::* ..: : *.**:***.**** *:*:**::.**:: *:*.:**.** ** : .*** .** ***.*: *: ******** * ...: .** :**: . **::**:.*:*: :* : ** *. :****** *:*:.**: : * . .. : : ", "identical_positions": 124, "similar_positions": 99, "identity": "34.44%" }, { "cls_id": "homologset.agr.HGNC:17187", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88998-1", "uniprot_id": "NOE1_MOUSE", "id": "O88998-1", "name": "Noelin", "aln": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLETKFKQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTEAILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPVSLQILQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQTLYNVTLFHVIRSDEL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q62609-1", "uniprot_id": "NOE1_RAT", "id": "Q62609-1", "name": "Noelin", "aln": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPVSLQILQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQTLYNVTLFHVIRSDEL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99784-1", "uniprot_id": "NOE1_HUMAN", "id": "Q99784-1", "name": "Noelin", "aln": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAAGGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B7ZD15-1", "uniprot_id": "B7ZD15_DANRE", "id": "B7ZD15-1", "name": "", "aln": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLTAAQGGYPDRSIGVLPANPEESWQVYSSAQDSEGRCVCTVVAPQQTMCSRDARTKQLRQLLEKVQNMTQSIQVLDQRTQRDLQYVVKMEDQLRGLETKFRQVEENHKQNIAKQYKAIKAKMAELRPLIPVLEEYKADARLVQQFKEEVQNLTASLGLLQQEMGAYDYDDLHSRVVSLEERLRACMQKLACGKLTGISDAITIKTSGSRFGSWMTDPLAPEGDTRVWYMDGYHNNRFVREYKSMADFMTSDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSNMIIKFDFKTSTMSKSQRLDNAGFSNTYHYAWGGHSDIDLMVDEGGLWAVYATNQNAGNIVISKLHPITLHIIQSWTTNHPRRSAGESFMICGTLYVTNGYSGGTKVYYAYHTNSSTYEYIDIVLQNKYSHISMLDYNPRDRALYAWNNGHQVLYNVTLFHVIRSEQL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A2AWU1-1", "uniprot_id": "A2AWU1_DANRE", "id": "A2AWU1-1", "name": "", "aln": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNSTKLSVAPPGVPDRSTGVLPANPEESWQVYSSAQDSEGRCVCTVVAPQQTMCSRDARTKQLRQLLEKVQNMTQSIQNLDQRTQKDLQYVQRMEVQLRGLETKFKQVEESHKQNIAKQYKAIKAKMEELRPMIPVLEEYKADAKLVMQFKEEVKNLTSVLSELQEEIGAFDYEELHNRVSNLEERLRACMQKLACGKLTGISDAITIKTSGSRYGSWMTDPLAPDGDTRVWYMDGYHNNRFVREYKSMADFMYSDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSNTIIKFDFKTATISKSGQLDYAGFNNRYHYSWGGHSDIDLMVDEGGLWAIYATNQNAGNIVISKLNPATLQIVKSYTTNHPKRSAGEAFMICGTLYVTNGYSGGTKVYYAFHTNSSTYEYIDIPLQNKYSHISMLDYNPRDRALYAWNNGHQVLYNVTLFHVIRSEEL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*********************************:*:*:.* * *** ****:*******************:******************************:***: **:***:***** :** *::***:**:****.***::*:*:******* ****:***********:** ******:***: *. **:*:**:**::*:.** .**********************.:*:******:**********:**.********************.*** :*******************************: **:**:** :: *: ** **:.* ***:*************.****:***********:*:*.* :*: ::::.*.:*:*****:*:*****************:**::**:******** :**************:************ ************::*", "identical_positions": 385, "similar_positions": 75, "identity": "79.38%" }, { "cls_id": "homologset.agr.HGNC:17189", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BM13-1", "uniprot_id": "NOE2_MOUSE", "id": "Q8BM13-1", "name": "Noelin-2", "aln": "--------------------MRKLRQTG-------TTIAGG------QTLFQSPEEGWQLYTSAQAPDGKCVCTAVIPAQSTCARDGRSRELRQLMEKVQNVSQSMEVLELRTFRDLQYVRSMETLMRSLDARLRAADG---SVSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTAGDP----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95897-1", "uniprot_id": "NOE2_HUMAN", "id": "O95897-1", "name": "Noelin-2", "aln": "--------------------MWPLTVPPPLLLL-LCSGLAG------QTLFQNPEEGWQLYTSAQAPDGKCICTAVIPAQSTCSRDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRGMETLMRSLDARLRAADG---SLSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVMRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTSGDP----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q568Y7-1", "uniprot_id": "NOE2_RAT", "id": "Q568Y7-1", "name": "Noelin-2", "aln": "MSVPLLKIGAVLSTMAMVTNWMSQTLPSLVGLN-STVSRAGSSE--KITLFQSPEEGWQLYTSAQAPDGKCICTAVIPAQSTCARDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRSMETLMRSLDARLRTADG---SVSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTAGDP----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "F1R5K6-1", "uniprot_id": "F1R5K6_DANRE", "id": "F1R5K6-1", "name": "", "aln": "MSVPLLKIGAVLSTMAMVTNWMSQTLPSLVGLNGTTISRAGTSERIVSALYPSPEEGWQIYSSAQDADGKCICTVVAPAQNMCNRDPRSRQLRQLMEKVQNITQSMEVLDLRTYRDLQYVRDTENLMKTVDGKLKTASENPRSLNPKSFQELKDKVTQLLPLLPVLEQYKADARMILRLREEVRNLSLVLMAIQEEMGAYDYEELRQRVLLLETRLHSCMQKLGCGKLTGVSNPITVRASGSRFGSWMTDTMIPSSDNRVWSMDGYFKGRRVLEYRTMNDFMKGQNFVQHLLPHPWAGTGHVVYNGSLYYNKYQSNILIKYHFRSRSVLVQRSLSGAGYNNTFPYSWGGSSDIDLMADENGLWAVYTTIPNAGNIVISRLEPQSLEVLQTWDTGFPKRSAGESFMICGTLYVTNSHLAGAKIYFAYYTNTSTYEYTDIPFHNQYSHISMMDYNPRERVLYTWNNGHQVLYNVTLFQVIKTAED-----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0R4ILX8-1", "uniprot_id": "A0A0R4ILX8_DANRE", "id": "A0A0R4ILX8-1", "name": "", "aln": "MSAALLKLGAVLSTMVLISNWMSQNLPALVGLD-QHTAAPGTSEKIISVLYPGQDEGWQVYGSAQG---RCVCSIKTPVPDACAGDPRHTRLQQISAHVLNVSEHMQLLTRRTAGDLQELRSSETILDTLEKTLTSAQQNPQELSDRSLQELRWSVSQCRPLRVLLTRVRADVAQLDSVRDELQGISVSLSLLQERFTLQHYQQLQQRISILQQHLHSCSSHLGCGQLISISAPLTVRSSGSRFGSWMMETSIESSDNRVWVMDGYLKGRRVLEYPSLQDFASGQNYIVHHLPHAWAGTGHVVFNGSLYYSKHQSSVLVRYGLASGSVLQQRELPDAGFNNTFPYSWGGASDIDLMVDGSGLWAVHSSAGRGGTLLLSRLHPLSLQVLRSWDTGFPKRSAGEAFLICGTLYITDSHLPGAKVAFRFHTHTHTYQYTDIAFHNQYSHISMLDYNPRTRALYTWNNGQQVLYQLTLMHYIHTHTPLTHTHTNDTHA", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * .*: . :****:* *** :*:*: *. . * * * .*:*: :* *::: *::* ** *** :*. *.:: ::: * :*. .:. :*:***: ::: ** :* : :**. : :*:*::.:* * :**.: *::*:**: *: :**:* .:****:* .:* *:*:*: ******** :* *:*.*** **** *******: :: ** .***:: * **:.********:****:*.*:**.::::* : * *** **.*..**:********** **:*:*.* .*****::: ..*.:::***.* :*:*:::****:*******:*:***.**:*:***.***: * :.*:* :*:***:.**********:***** *.*******:****::**:: * * ", "identical_positions": 211, "similar_positions": 134, "identity": "42.71%" }, { "cls_id": "homologset.agr.HGNC:1719", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LEH4-1", "uniprot_id": "A0ABK0LEH4_RAT", "id": "A0ABK0LEH4-1", "name": "", "aln": "MKRKSERRSAWATAPPCSRRSSSSSPGVKKSRSSTPQELHRLEQQDDLYLDITDRLCFAILYS--RPKSASNEHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIIHFTGTDQRKQANAAFLIGCYMVIYLGRAPEDAYRTLIFGDT-AYIPFRDAAYGSCSFYITLLDCFHAVKKAIQYGFLNFNSFNLDEYEHYEKAENGDFNWIIPERFLAFCGPHSRSR-----LESGYHQHSPETYIPYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAEAIVQEFLDICENVE---GAIAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYFRQK----------------------------------LRGQENGALREAFSKHLSDVDDISINGLENQDSQ--------------------EPEPYSDDDE----------------------------------------------------------------------------------------------------VSGVTQGDRLRALKSRRQPKTN-------AIPLTVILQSSVQSSKTPEPNLSGSAGITKRTTRSASGKSSLKSLAPWRERRRRSA------------------------------------LQHMPMLALCPAISRTKTVLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6PFY9-1", "uniprot_id": "CC14B_MOUSE", "id": "Q6PFY9-1", "name": "Dual specificity protein phosphatase CDC14B", "aln": "MKRKSERRSAWATAPPCSRRSSSSSPGVKKSRSSTPQELHRLEQQDDLYLDITDRLCFAILYS--RPKSATNEHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIIHFTGTDQRKQANAAFLVGCYMVIYLGRTPEDAYRTLIFGDT-AYIPFRDAAYGSCSFYITLLDCFHAVKKAMQYGFFNFNSFNLDEYEHYEKAENGDFNWIIPERFLAFCGPHSRSR-----LESGYHQHSPETYIPYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAESIVQEFLDICENVK---GAIAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYFRQK----------------------------------LRGQENGPLREAFSKHLSDADDLSLNGLENQDNQ--------------------EPEPYSDDDE----------------------------------------------------------------------------------------------------VSGMTQGDRLRALKSRRQPKAS-------AIPLTCPLAVLT---------------------------SALCSVAIWWIVCD----------------------------------------YILPTLLFCLDGFRTQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60729-1", "uniprot_id": "CC14B_HUMAN", "id": "O60729-1", "name": "Dual specificity protein phosphatase CDC14B", "aln": "MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDPRRRDPQDDVYLDITDRLCFAILYS--RPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGET-SYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRAR-----LESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAE---GAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQK----------------------------------LKGQENGQHRAAFSKLLSGVDDISINGVENQDQQ--------------------EPEPYSDDDE----------------------------------------------------------------------------------------------------INGVTQGDRLRALKSRRQSKTN-------AIPLTVILQSSVQSCKT----------------------SEPNISGSAGITKRTTR------------------------------------SASRKSSVKSLSISRTKTVLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BE48-1", "uniprot_id": "A0A8M2BE48_DANRE", "id": "A0A8M2BE48-1", "name": "", "aln": "MKRKSERR--------CGSR--------KRICAS-------LRDRSDIQLHITDQLYFALLHQ--KVRSTPDRHCFCIDEELSYENFYADFGPLNLAMLYRFCCKLKKKLKSCAHAKKKIVFYTYGDRKKQANAAYLIGSYAVMHLQKTPEEAYSLLVSQNA-PYLPFRDASFGACMYNLNILDCLRAVHKALQFGWLDFTQFNVEEYEHYERAENGDFNWILPGKFLAFSSPHPKSK-----IENGYPLHAPEAYFPYFRKHNVTTIIRLNKKMYDSKRFTDVGFKHHDLFFVDGSTPNDSIVSRFLHICENAD---GVIAVHCKAGLGRTGTLIGCYLMKHFRLTAAEAIAWIRICRPGSVIGPQQNFVDEMQSSLWAEGELYRQK----------------------------------INEQENGSAKTAVAGILSGVEDISINGTNKSTSQR-----------------KTASQNHTEEEEED--------------------------------------------------------------------------------------------------CAGLTQGDKLRALKSKRQSRASTG---SISLEENTVHTKSTSKSLSSEKRKRTRASLGSNRASSPLHSRLAKSLGSLQVVACETDGVFCD--------------------------ISDASVANNNSFIKQSNIKHLRSISSAAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLW7-1", "uniprot_id": "Q9VLW7_DROME", "id": "Q9VLW7-1", "name": "", "aln": "MLDDDNSD--------------------LLVCASEMQE---------------DRLYFVAFKKNIKPKNTVNTHYFSVDEEFIYENFYNDFGPLNICMLYRYCMKLNTKLNAKCHANKKIVHYTSMNPAKRLNAAYLIGSYAIIYLNKTPQEAYRPLVAGEIPAYTRFCDASYGPSNFKISLLDCLNAVHKGLQAGFFNFNDFDAEEYEYFERVENGDFNWIVPQKFIAFCGPHQKSKT----LPNGYPCHAPERYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPSDAIMKKFLSICETTK---GAIAVHCKAGLGRTGSLIGAYIMKHYGFTALEAIAWLRLCRPGSVIGHQQQWMEDKQSWLWSEGERMRRRTSLPILQHTYGINSLELKKKLASAAADSTEHVDLLLTRVKGISQRVDTMHLNDQDNLDAACTDQTDEELSEQLRLERDERALYQSVEDPNCNNSDDNDTDTISAPADPPPTSSYTISTRRRKSPSGANKPTVIATSLRRLVNPNANRSGLSTASGVYPTPELASCTEKKLRKPSANVFEAARHTIASTVRMTQTALEKKQAQTQGDKLNQIKALRRHHSRSVNVNSNSSEQESNVRHTRARSQPFRNNNNGVGGNTAMAALKPTSSCLPTGTGTAALLANNLNNNNDCGIGTSGSSNNNHNNNNNNSNLSNSLNNYNNNNNTTNNILASSGSSRTRSLALYSKRMELKHLRKAEQQQQQQVQQEQPLLPVEKQLLRQYATINESKIPVVSGGGGGAGSSATIPPTRGSAARTSHHHMTLRGRSRIRYQRPNAGETAPAAAQTQPCTVATARYYRDVSAIPTIGVFGGGPGGSSSTSASFNIATRSASATLDLNSNPLPKTTKLTSLNNNPTTTPPPSSNPADTSRLSGRGSAELQAIIEHGLVAGSAKRNKRSLSSTRLDKDKSDEYNTKLLRKTAAAAAAAATAASAVANSTSINATHATNASTTSSMNNNCKYNSCSSSNSGSFKLSRRLFGESGSSASTSASNSGIPTPTAPPSSSQWQQHLVRGVSRASSEKDRDRERQQQQQQQSLDHQQSNLKLRKKISY", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q00684-1", "uniprot_id": "CDC14_YEAST", "id": "Q00684-1", "name": "Tyrosine-protein phosphatase CDC14", "aln": "MRRSVYLDN--------------------------------------TIEFLRGRVYLGAYDY--TPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDP-PFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPD-FIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIG-------------GLYPLISLEEYRLQKKKLKDDKRVAQNNIEGELRDLTMTPPSNGHGALS---------------ARNSSQPSTANNGSNS-----------------------------------------------------------------------------------------------FKSSAVPQTSPGQPRKGQNGSNTIEDINNNRNPTSHANRKVVIESNNSDDESMQDTNGTSNHYPKVSRKKNDISSASSSRMEDNEPSATNIN-------------------------------NAADDTILRQLLPKNRRVTSGRRTTSAAGGIRKISGSIKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . .:: : ..: : * ::: : *:.*: ****:*: :**:. :: *: .* ::.:: . :: *** :: .* :: :*.:. * : .: * **.:. . : :.: * . .* :. : * ::: .*: :.** :*:.* **:* : * *:**..*: ..: :. : : :* .:** ::*** ::*. . * : *:.* **:* **: * :*:..*: .*. * ************* **..::: : :** * *.::*: *** *:* **::: *. : * : :. : . . :: .: : :: . .* . . *. . .: . . : ", "identical_positions": 89, "similar_positions": 143, "identity": "8.14%" }, { "cls_id": "homologset.agr.HGNC:17190", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZMI6-1", "uniprot_id": "D3ZMI6_RAT", "id": "D3ZMI6-1", "name": "", "aln": "MCYSRLLLLSLLFCLGSASGSSRALSSTH-SLELTTPTLPETTLPETTTAWLPSGGT-SWTEGGTLSQSLSNFTGSVDSHGTCQCSVSLPDTTFPADRVERLEFTAHTLSQKFEREFSKVKEYVQLISVYEKKLLNLTVRVEVMEKDSISYTELDFELIKLEVKEMHKLVIQLKENFVGSTDIIDMLEVEIRNMTLLVEKLETLDQNNVLSIRRQILALKTKLKECEDSKSGLVPATPPPPAPGSCSHGGVVNISAPFVVQLNFQG-FNYKYGAWGRDYSPQHPERTLYWVAP-----LNTDARVLEYYRLYDSLDNLLLYSHSRQYRILYGQGGGTVAFNNSLYVNWYNGRNIAKIDLTTNGVTVNQPLPQAAYNNRFSYANVNWQDIDLAVDEQALWAIYATEASTGNIVISKLNDTTLEVISTWVTKQYKPSVSNAFIVCGVLYATRTLNTRTEEIFYYYDTNTQREGSLAITMRKMQERIQSINYHPYDHKLYVYNDGYLLNYDLVFLQTPKQPV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UZZ4-1", "uniprot_id": "OLFM4_MOUSE", "id": "Q3UZZ4-1", "name": "Olfactomedin-4", "aln": "MSYSLLFLLALQFCLGSASRTT--LTSAH-SRELTTP----PTSPQATAAWLPPGGT-SWAEGGTVSQPLSNFTGSVDSHGTCQCSVSLPDTAFPADRVERLEYTAHILSQKFEREFSKVKEYVQLISVYEKRLLNLTVRVEVMEKDSISYTELDFELIKLEVKEMQKLVLQLKKNFVGSTHIIDMLEVEIRNMTLLVEKLESLDQNNVLSIRRQILALKTKLKECEASKSDLVPATPPPPAPGSCSHGGVVNISAPSVIQLNWLG-FSYKYGAWGRDYSPQHPERTLYWVAP-----LNTDARALEYYRLYDSLDNLLIYSHFRDYRIRYGQGGGTVAFNNNLYVNWYNGGNIAKINLTTNVVDVNRPLPLAAYNNRFSYANVNWQDIDLAVDEQALWAIYATEASTGNIVISKLNDTTLEVISTWVTKQYKPSVSNAFMVCGVLYATRTLNTKTEEIFYYYDTNTEREGNLGITMRKMQERIQSINYHPFDQKLYVYNDGYLLNYDLVFLQTPRQPV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6UX06-1", "uniprot_id": "OLFM4_HUMAN", "id": "Q6UX06-1", "name": "Olfactomedin-4", "aln": "MRPGLSFLLALLFFLGQAAGDLGDVGPPIPSPGFSSFPGVDSSSSFSSSSRSGSSSSRSLGSGGSVSQLFSNFTGSVDDRGTCQCSVSLPDTTFPVDRVERLEFTAHVLSQKFEKELSKVREYVQLISVYEKKLLNLTVRIDIMEKDTISYTELDFELIKVEVKEMEKLVIQLKESFGGSSEIVDQLEVEIRNMTLLVEKLETLDKNNVLAIRREIVALKTKLKECEASKDQNTPVVHPPPTPGSCGHGGVVNISKPSVVQLNWRG-FSYLYGAWGRDYSPQHPNKGLYWVAP-----LNTDGRLLEYYRLYNTLDDLLLYINARELRITYGQGSGTAVYNNNMYVNMYNTGNIARVNLTTNTIAVTQTLPNAAYNNRFSYANVAWQDIDFAVDENGLWVIYSTEASTGNMVISKLNDTTLQVLNTWYTKQYKPSASNAFMVCGVLYATRTMNTRTEEIFYYYDTNTGKEGKLDIVMHKMQEKVQSINYNPFDQKLYVYNDGYLLNYDLSVLQKPQ---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q2M7-1", "uniprot_id": "A0A8M9Q2M7_DANRE", "id": "A0A8M9Q2M7-1", "name": "", "aln": "MMMMMKILLLSVFMLAAP-----------------------------AQAWLS---LEDWGSG--------SVDGSIGDLGQCVCNVFLPDTSFPADRMEQMQSSSKQLAVEVQIHISKLSSLKVELVVLLESLSNLTARLEVLESGPDKYIKLEFELLRVELREFEALVTQIKTSLNSSSSAFDSLYAEIHSMRIIVDQLESYDRSNLEVIRHEFTKLQRKLKKCQEDQQDITNAP-----IGSCKHAGILKIGKPVVSQLNADLNGAFKYGGWGKDSKPLSGSESMYWYSGSSDTLVSKISQYSAYYTLITRQSFKAHLLYVDRQYDWRGAGNNYVVRENNLYYQYRSPFAMAKFNMTSAKVET-KVVPKAST--QFSYHYSINQNLDFAADESGLWVTYATADSNGTLVLGKINEQSFTVEEVWQTSIFKQSVTNAFMICGVLYATRSVDTHTEEIFYTYDTTKNQESHVSIRFEKFQDFYVYLDYNPADQKLYMFNNGYYVTYNLKFKVV-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :** * *. . : : . .* .. **:.. * * *.* ****:**.**:*::: ::: *: :.: .:**: . : * : * ***.*::::*... .* :*:***:::*::*:. ** *:* .: .*: .* * .**:.* ::*::**: *:.*: **::: *: ***:*: .:. . . *** *.*:::*. * * *** : **.**:* .* .. :** : :.. .: ** * . * *.. .. :*.:* : . :*:.::*: : . : :* *: :*** *::*:*.**..**. *:* *.*.:*:.*:*: :: * ..* *. :* *.:***::********:::*:****** ***.. :*. : * :.*:*: ::*:* *:***::*:** :.*:* . ", "identical_positions": 148, "similar_positions": 167, "identity": "28.52%" }, { "cls_id": "homologset.agr.HGNC:17192", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0M8H9-1", "uniprot_id": "A0ABK0M8H9_RAT", "id": "A0ABK0M8H9-1", "name": "Toll/interleukin-1 receptor domain-containing adapter protein", "aln": "MVGLEACAMASSSSVPASSTQSKKPRDKIADWFRQALLKKPK-KMPISQESHLSDGSQTATQDGLSPSSGSSPRSHSSSQSQSSTPSCSSGMSPTSPPTHVDSSSSSSSGRWSKDYDVCVCHSEEDLEVAQELVSYLEGSKASLRCFLQFRDAAPGGAIVSELCQALSGSHCRVLLITPGFLRDPWCKYQMLQALTEAPGSEGCTIPLLSGLTRAAYPPELRFMYYVDG-RGQDGGFYQVKEAVIHCKTQEGWEGGEGSSSVCLYK-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99JY1-1", "uniprot_id": "TIRAP_MOUSE", "id": "Q99JY1-1", "name": "Toll/interleukin-1 receptor domain-containing adapter protein", "aln": "--------MASSSSVPASSTPSKKPRDKIADWFRQALLKKPK-KMPISQESHLYDGSQTATQDGLSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHVDSSSSSS-GRWSKDYDVCVCHSEEDLEAAQELVSYLEGSQASLRCFLQLRDAAPGGAIVSELCQALSRSHCRALLITPGFLRDPWCKYQMLQALTEAPASEGCTIPLLSGLSRAAYPPELRFMYYVDG-RGKDGGFYQVKEAVIHYLETLS-------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P58753-1", "uniprot_id": "TIRAP_HUMAN", "id": "P58753-1", "name": "Toll/interleukin-1 receptor domain-containing adapter protein", "aln": "--------MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPK-KRPNSPESTSSDASQPTSQD--SP----------------LPPSLSSVTSPSLPPTHASDSGSSR---WSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDG-RGPDGGFRQVKEAVMRYLQTLS-------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z2S6-1", "uniprot_id": "A0A8M6Z2S6_DANRE", "id": "A0A8M6Z2S6-1", "name": "", "aln": "---MSCICLLQFISLKGWRRMEEKRVSGVMSWFRERFGRQRNGQEQINPYENPPPPSHPSDLS-------------------ISTSICSSSSSHQHLPSFLSSSLRSA-----LKYDLYLCHSEKDMEQAQSLATFLEQPGKSLRCFLQERDCALGGAVSTELLQALRDSHCWLLLITPHFLKDDWCLYQMHQVLSEGPMSQR-IIPSVLDMPRSELPLELRFLFTVDLNVNREFGFKQVYSTVLHYLKDVCEKETSSSVSQTDRREESQL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . *: . :* . : .***: : :: : : . . *:.: . .. ** * *:. ..* * .**: :****:*: **.*.::** . ******* **.: ***: :** *** *** ***** **:* ** *** *.*:*.* :: ** : .:.*: * ****:: ** . : ** ** .:*:: ", "identical_positions": 76, "similar_positions": 59, "identity": "28.04%" }, { "cls_id": "homologset.agr.HGNC:17194", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9P0J0-1", "uniprot_id": "NDUAD_HUMAN", "id": "Q9P0J0-1", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "aln": "----MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVG-------ESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9ERS2-1", "uniprot_id": "NDUAD_MOUSE", "id": "Q9ERS2-1", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "aln": "----MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFAVGIGALIFGYWRMMRWNQERRRLLIEDLEARIALMPLFQAEKDRRTLQILRENLEEEAIIMKDVPNWKVG-------ESVFHTTRWVPPLIGEMYGLRTKEEMSNANFGFTWYT-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZE15-1", "uniprot_id": "D3ZE15_RAT", "id": "D3ZE15-1", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "aln": "----MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFALGIGALIFGYWRIMRWNRERRRLLIEDLEARIALMPLLQAEKDRRTLQILRENLEEEAIIMKDVPNWKDA-------LPGVPSTR-MKVMQYSMSQQCLLGSVHPTPPVHTWKGSEEGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9W402-1", "uniprot_id": "Q9W402_DROME", "id": "Q9W402-1", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "aln": "MATAVPHCPPKQDLPPPGGYKKIPFARVPPKSYFTGFTTIGTYVVVTAVGLGIYYLTAKKVKRDEIEMRSAQNVIFPILVAERDREFLRQLRRNRDEEAELMKNVPGWEVGTWYGEPVFKTLPEDTLVTPIFKEFYAHSDWKSYAKRAHLKLWS------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. . ***:****** * : * *: ::*:: :. : . * :: :* ** .*: .::*:: ** **. *: **.* :*** :**:**.*: . . : : .: . * ", "identical_positions": 36, "similar_positions": 39, "identity": "22.5%" }, { "cls_id": "homologset.agr.HGNC:17195", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3V140-1", "uniprot_id": "ACRBP_MOUSE", "id": "Q3V140-1", "name": "Acrosin-binding protein", "aln": "MMNLAAGFLLMLLEVLLLPGTPLSAEES-PASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQR-KQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDS--WRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6AY33-1", "uniprot_id": "ACRBP_RAT", "id": "Q6AY33-1", "name": "Acrosin-binding protein", "aln": "-MKLAASFLLMLLEVLLLPETPLSAEEA-LASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPLTSVTTPIVSRATATEHQAFQPWPERLNNNVEELLQSSLSLGGKEQQSSRKLGLEQQHKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEEGLDSVSRLQSDSEPKFQSKSLSSNPSFFTPRVREVESAPLMMENIQELIRSAQEMDEMNELYDDS--WRSQSTGSLQQLPHTETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQQCDASHKIPFISPLLSAQSISTGNQAKIPEKGRFAGLEMYGGLSSEFWCNRLALKGCEDDRVANWLKAEFLSFQDGDLPTKICDTNYVQYPNYCSFKSQQCLLKNQNRKMSRMKCMLNEKYHVLSPAKGEEVILRWSQEFNTLTLGQFG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NEB7-1", "uniprot_id": "ACRBP_HUMAN", "id": "Q8NEB7-1", "name": "Acrosin-binding protein", "aln": "MRKPAAGFLPSLLKVLLLPLAPAAAQDSTQASTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSNLPYASWFESFCQFTHYRCSNHVYYAKRVLCSQPVSILSPNTLKEIEASAEVSPTTMTSPISPHFTVTERQTFQPWPERLSNNVEELLQSSLSLGGQEQAPEHKQEQGVEHRQEPTQEHKQEEGQKQEEQEEEQEEE-GKQEEGQGTKEGREAVSQLQTDSEPKFHSESLSSNPSSFAPRVREVESTPMIMENIQELIRSAQEIDEMNEIYDENSYWRNQNPGSLLQLPHTEALLVLCYSIVENTCIITPTAKAWKYMEEEILGFGKSVCDSLGRRHMSTCALCDFCSLKLEQCHSEASLQRQQCDTSHKTPFVSPLLASQSLSIGNQVGSPESGRFYGLDLYGGLHMDFWCARLATKGCEDVRVSGWLQTEFLSFQDGDFPTKICDTDYIQYPNYCSFKSQQCLMRNRNRKVSRMRCLQNETYSALSPGKSEDVVLRWSQEFSTLTLGQFG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : **.** **:***** :* :*::: *********.****************************************************:*************::************* ***************:*:****. *::*:** .: *.**:*:********.***************::* ..:: . :** **** **.*:*******:*** .********: * ::**:**:******:*:******* *:********:*::*:***********:*****:**:. **.*..*** **** *:*:******:**** :*******.**********.****.***** ::*.** **************: **:**:*** **:****::**:* ***. *:.*** **::**** :*** *** ***** **:.**::******:**:*******:*:**************::*:***:***:*: ** * .** .*.*:*:*******.**::****", "identical_positions": 395, "similar_positions": 100, "identity": "72.61%" }, { "cls_id": "homologset.agr.HGNC:17196", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AAN8-1", "uniprot_id": "D4AAN8_RAT", "id": "D4AAN8-1", "name": "DNA helicase B", "aln": "--MAGQG-VLRELLGPLNPYKSDDE--EEDCAQEE-GEQDSE--FVDAEELCSGGIKAGSLPGRMRVS--IPDENTKEKCTVYGRFPLKDPWWRVRVRVVKH-AQSSKSYQVQGFPSYFLQSDMSPPDQKSICSLFLKECNFTPERIQEFLKWVDKVSSFENLNFENLRETFRNFCRETTKKDKMQSTQSDQ-------GDEQKLEKSFPFVIAMTALQFPKVMEFLPTLFPRHFKSLISSC--------------------SETVLGHIEEALGT-QPWKLGFRRITYREMKLLSCEASWTSFSQCPSLLQLMTALQKNALVLYSKLRQTCREDGHTYIKVKDLTWGLSEHMSFEEACQSLDFLRTIDVITYEKDFIFLSELYQAEHDIASFICELMNRPPWHLKVDVRNVL--ASIGGAKSTDSGSTEAVEGSKPDEVEVEVAAEQGDSVLGAQ----------------------DSGDHVRSNGEHVTSAEIN---------RVPLDRDQVVALETICTNAVTVLSGKGGCGKTTIVSRLFKHVEQLEE---REVQQACEDFEQDQGASEEWLDFPKQSP-------AGVDKAIEVLLTAPTGKAAGLLRQKTHLPAYTLCQVNYSFYMWK--KNEADKPWKFSTVRVLVVDEGSLVSVAIFKSVLKLLREHSKLSKLVILGDVRQLPSIEPGNMLQDVFETLKSRQCAIELKTNHRTESQLIVDNAARISRRQFPEFDAEINISDNSTLP---NSIQDKTFIFVRLPEEDSSSQSSKGKHQADLYSAVKTLLQGKDFCSPESAKTSQFIAFRRQDCDLINDCCSKHYTDHLIKDHKKKLIFAVGDKICCTRNAYLSDLLPD--------RDQEANGKGFGDAPDDNAKGKQDFESSIRLCNGEIFFITRDVTDVTSKRK----RLLTISNDAGLEVTVDFNKLMTNCQIKHAWARTIHTFQGSEEKTVAYVVGKAGRQHWQHVYTAVTRGRSRVYIIAEESELRSAIRKRSFPRQTRLKHFLQKKLSSSCASSEGLPSQPSSPRVG----GRPDTQPLASPLCTTPGSKATAN---------SARGEASPATKERFALDGRWLSTCFS-DMDTDEES----------------------------EQLRGSKRTGDGFPFEEESPSKFRMVEESSPQVSSIFQSLRLNN---LTRRQLFKPSDNQETAKSGVVDHTNNASNQETEP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6NVF4-1", "uniprot_id": "HELB_MOUSE", "id": "Q6NVF4-1", "name": "DNA helicase B", "aln": "--MARQD-RLRELLGPLHPYKSDDE--EEDCAQEEEGEQEEE--FVDAEELCSGGIKAGSLPGRARVS--IPDEYTKEKCTVYGRFPLKGPWWRVKVQVLK--PQRSRSYQVQGFPAYFLQVDMSPPDQKQICSLFLKECNLASERIQEFLKWVEKVSSFENLHFENLWETLRLFYRETEKKDKKLSTPREQQ------GEEMRVEKSFAFISAMVALQFPKVMEFLPSLFPRHFKRLISSS--------------------SDWVLGCIEDVLGT-QPWKLGFRRITYREMKLVRCEASWTAFSQCPSLLQLMTPLQKNALVIYSKLRQTCREDGHTYIEVKDLTSGLSEHMSFEEACQSLAFLKDIDVVIYEKDYVFLSELYEAEQDIASSICELMSRPPWHLKVDVKNVL--ASIRGAKPNDPGSAEAVEGSKPE----EVGSEQGDSVLDAQ----------------------DGDDHVRSNGEHVANAEIN---------DVPLDQDQVVALETICANAVTVLSGKGGCGKTTIVSRLFKHMEHLEE---TEVQQACEDFEQDQEASEEWLDCPKQSP-------AGVDKAVEVLLTAPTGKAAGLLRQRTDLPAYTLCQVNYSFYMWKT-KNEVDKPWKFSTVRVLVVDEGSLVSVGIFKSVLQLLCKHSKLSKLIILGDVRQLPSIEPGNMLQDVFETLKSRQCAIELKTNHRTESQLIVDNATRISRRQFPKFDAELNICGNPTLP---LSIQDKTFIFVRLPEEDSRSQSSKGEHRSNLYTAVKTLLQGKDFCSFESSKTSQFIAFRRQDCDLINDCCCKHYTGHLIKDHEKKLIFAVGDKICCTRNAYLSDLLPD--------KDQEAEGKGYGDAPDDDAKIKQDFESSTRLCNGEIFFITRDVTDVTFKRK----RLLTINNEAGLEVTVDFSKLMANCQIKHAWARTIHTFQGSEENTVVYVVGKAGRQHWQHVYTAVTRGRSRVYIIAQESELRSATRKRGFPRQTRLKHFLQKKLSGSCAPSTGFASQPSSPRVG----GRPDTQPPASHLCRTPDNKATAD---------SARGDE------------RWLSASVNDDVDTDEES----------------------------AQLRGSKRIGDGFPFDEESPSKFRMVEAPSPQVSSVFQNMRLNT---LTPRQLFKPTDNQDTGTAGVADDANDPSNQEMEM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NG08-1", "uniprot_id": "HELB_HUMAN", "id": "Q8NG08-1", "name": "DNA helicase B", "aln": "--MARSSPYLRQLQGPLLPPRDLVE--EDDDYLNDDVEEDEESVFIDAEELCSGGVKAGSLPGCLRVS--ICDENTQETCKVFGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSPPNQKHICALFLKECEVSSDDVNKFLTWVKEVSNYKNLNFENLRETLRTFHKETGRKDQKQPTQNGQEELFLDNEMSLPLENTIPFRNVMTALQFPKIMEFLPVLLPRHFKWIIGSG--------------------SKEMLKEIEEILGT-HPWKLGFSKITYREWKLLRCEASWIAFCQCESLLQLMTDLEKNALIMYSRLKQICREDGHTYVEVNDLTLTLSNHMSFHAASESLKFLKDIGVVTYEKSCVFPYDLYHAERAIAFSICDLMKKPPWHLCVDVEKVL--ASIHTTKPENS-SDDALNESKPD----EVRLENPVDVVDTQ----------------------DNGDHIWTNGENEINAEISEVQLDQDQVEVPLDRDQVAALEMICSNPVTVISGKGGCGKTTIVSRLFKHIEQLEE---REVKKACEDFEQDQNASEEWITFTEQSQ-------LEADKAIEVLLTAPTGKAAGLLRQKTGLHAYTLCQVNYSFYSWTQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIFKSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQLIVDNATRISRRQFPKFDAELNISDNPTLP---ISIQDKTFIFVRLPEEDASSQSSKTNHHSCLYSAVKTLLQEN---NLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLTKDHQSRLVFGIGDKICCTRNAYLSDLLPENISGSQQNNDLDASSEDFSGTLPDFAKNKRDFESNVRLCNGEIFFITNDVTDVTFGKR----RSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYVVGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGAPPADFPSPRKSSGDS----GGP-STPSASPLPVVTDHAMTND---------VTWSEASSPDERTLTFAERWQLSSPD-GVDTDDDL----------------------------PKSRASKRTCG--VNDDESPSKIFMVGE-SPQVSSRLQNLRLNN---LIPRQLFKPTDNQET-------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0UYS3-1", "uniprot_id": "B0UYS3_DANRE", "id": "B0UYS3-1", "name": "DNA helicase B", "aln": "MALQSPIAGLKTITGYILPEEQAVQPNKDDGLESEDEEEEGQPEFLDMKEMNSVSSGGNMFKSLVPTSKEVSILVGKKTYKVEGRFPLCDPWWEVTCTIRLG----RLKAFVKGYPFYRLRTHLKS-EGRSLLSLFLTACKAQADHVKMFMDWLPTDRRVELVNVLDVLQEFEDSSLEHEAVAQQLKS---------------SVNCSVVWTHVKAASLYPGIMKYLPTLLPGQYLDIIKRARIEDIPETSAMDEDPQNEQRKTNVLSKLEELINTNNVWKLGFNYIMFKELHLIRCEAKLEAFKLCD-LFSAIPLLQRNALILYAELKKHCRVTGSTYITQEMLVDKIFSETGADGAWAALHFLVTQGVLMKESTKVALRNLLKYEKGIAECLTGLVQGDPWKIHLDVKEVLREAQIKRLRAKACEKHNATMKSKDDANTSASAAENSTAVFEQLGIDLDQPGTSSMVHNGETPSCDDSENTTLTIKEENLTSDSDS-DLDIDPSTIELDCDQVRAAEMMCANPVTVISGKGGCGKTTVVSLVFKAAMEQQTSDLEEVQKACEDFQNDSHGSSNGLALDVHEEKNHSEKSISNEKSVEVLLTAPTGRAASLLTKRTGFTAYTMHQVLWSFMTVDKDRSGNPQDWKFSKVRVLVVDEGSLVSVQILHSILSMLTKHAQLQKFIILGDVRQLPSIEPGNTLYDLFEGLRRVRWAIEMRTNHRAESELIVRNAGLISEMGKKKYYKPLDFDATIDMTNPSAVPSDKRFIFIKISSD---------NFSFDLQEAILFLLKEAP--GLKDHILSQFVAFRRKDCELINELCCRHYSNHTTKTAKKTFNFQVGDKVCCTKNGYVTDYDKK------ETSLADIRASHNRAESQQDDQKKEKKEKKERLCNGEIFFIKDDVTKSVENEKNKMVRQLTLDDKSDRQVTCNYKELQRECKLRHSWARTIHTFQGSEAETIVYILGDSPAQNWQHVYTAVTRGQKRVYVVGTEYDLEGAIRKRITPRNTRLCGFVNTKVGQQDPLTTSASTQRQAETTLNHSFGHSQSTPVASQTPIRPQMLSSTRPSCARNLYTDKNGEGDQTSNISLQDDMAFSQAYSWSPMDSCDEAGRVQNENMTELSNHVDDALLATLSSSPNESSRGSKRTIAEDIYSTPSKLPKQTASEESPMVSSRLNLLSLSSPDIKSSRQLFQDDTHSHRGQP----------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *: : * : * .. : ::* .: *:: : *:* :*: * . .. : . .* : ::. .* ****: ..**.* : . *:*:* * *: .:.. : : : :***. *: .: :: *: *: : ::. :: : :. * : : :: :. : . .* :* :*::** *:* :: :* . :* :*: :.* : ***** * ::* :*: ***. :* * *:. :. *::***::*:.*:: ** * **: : *. : .. . . * :* ** .*: *. : :* . *: ** : *:. **:: :**.:** *.* :. . :* ** : *: *. *. : : *. .:: . : ** *** * * :*:*.***:**********:** :** . : **::*****::*. .*.: : :. :*::*********:**.** ::* : ***: ** :** : ****.************** *::*:*.:* :*::*.*::****:********** * *:** *: . ***::****:**:*** ** **. :: ::: . :. .** ***:::..: :. * *: **: . :. ***:****:**:***: *.:**:.* * :. : * :***:***:*.*::* . : .. : : *.. *.. **********. ***. . .: * **:.: :. :** ::.:* *:::*:************ :*:.*::*.: *:***********: ***::. * :*..* *. **:*** *::.*:. . . . . .: .: * . : * ** . : .: : : :*: :: . *.*** . * . ** *** :: : *.. ****: :.. ", "identical_positions": 330, "similar_positions": 319, "identity": "26.81%" }, { "cls_id": "homologset.agr.HGNC:17197", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AE42-1", "uniprot_id": "A0A8I6AE42_RAT", "id": "A0A8I6AE42-1", "name": "Zinc finger protein 354A", "aln": "MAPDKREGKSQVSVTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASLGFPFTKPKMISVLQQGEEPWKAEKESHGCSSLGCNSSLQTTKSTQTKESSFQELKRKQLKRDEDWDFTSGKSCRPDNSFKKQ-NKNESLQIISITHTKILTVDKSHKNFEFGPSVSLKS--ISKQKIAREKT------QRNSLKENSTSLNQPKIKTLEKRFKCSTCEKAFIHSSSLRKHLKNHSGERLFQCKDCLKAFSQSSALIQHQRTHTGEKPYICNECGKAFSHSASLCKHLRTHTLEKSYTCKECGKSFSRRSSLFLHQKIHARENPHRYNPGRKAS---ASLSGCQRAHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKPYRCGECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSAALIQHQRIHTGEKPFKCNTCGRSFRQSSSLIAHQRIHTGEKPYECSACGKLFSQRSSLTNHYKIHIEEDSLNIDLHE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QXT9-1", "uniprot_id": "Z354B_MOUSE", "id": "Q9QXT9-1", "name": "Zinc finger protein 354B", "aln": "MAPEQREGKSQVSVTFEDVAVLFTRDEWKKLVPSQRSLYREVMLENYSNLASLGFPFTKPKMISVLQQGEEPWKSEKESHGCSPLGCHGSLQTTKSTQTKESLFQELKRKQLKRDEAWDFTSGKSCRPDNSFRTQ-DTNESLEIISINHTKILTIDKSRKNFKFGPSVGLKS--IGKQKIAGEKT------QRNSLEENSTLLSQPKLKTVEKRYKCSTCEKAFIHNSSLRKHLKNHTGERLFQCKDCLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTLEKSYTCKECGKSFSRRSGLFLHQKIHARENPHKYNPGRKAS---TSLSGCQRIHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCSECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRTHTGEKPYRCQECGMSFGQSAALIQHRRIHTGEKPFKCNTCGKSFRQSSSLIAHQRIHTGEKPYECSACGKLFSQRSSLTNHYRIHIEEDALNIDLHE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96LW1-1", "uniprot_id": "Z354B_HUMAN", "id": "Q96LW1-1", "name": "Zinc finger protein 354B", "aln": "MAAGQREARPQVSLTFEDVAVLFTWDEWRKLAPSQRNLYRDVMLENYRNLVSLGLSFTKPKVISLLQQGEDPWEVEKDSSGVSSLGCKSTPKMTKSTQTQDS-FQEQIRKRLKRDEPWNFISERSCIYEEKLKKQQDKNENLQIISVAHTKILTVDRSHKNVEFGQNFYLKSVFIKQQRFAKEKTPSKCEIQRNSFKQNSNLLNQSKIKTAEKRYKCSTCEKAFIHNSSLRKHQKNHTGEKLFKCKECLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTVEKCYRCKECGKSFSRRSGLFIHQKIHAQENPHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQHQRIHTGEKPFKCNTCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDSLKADLHV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. :**.:.***:********** ***:** ***.***:****** **.***:.*****:**:*****:**: **:* * *.***:.: : ******::* *** **:***** *:* * :** ::.::.* :.**.*:***: ******:*:*:**.:** .. *** * :*::* *** ****:::**. *.*.*:** ***:***********.****** ***:**:**:**:**************************:********************:**.* ************.**:******:****:******** :****.*: * ***:*****************************:*****************************.***********************:**************************************************************.************** *******:* ***************:***************::**********************.****************:******:*: *** ", "identical_positions": 484, "similar_positions": 84, "identity": "78.96%" }, { "cls_id": "homologset.agr.HGNC:17198", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZRM3-1", "uniprot_id": "D3ZRM3_RAT", "id": "D3ZRM3-1", "name": "Hexosyltransferase", "aln": "---MAARGRRAWLSMLLGLVLGFVLASRLVLPRASELKRVGPRRRPNPEGCRPGQAAS-QPGGAPGDARGAQLWPQGSAAEGVPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVEFFSSEGSDTSIPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLESFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENFCMGGPGVILSREVLRRMAPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHSSKIHRAITLHPNKNPPYQYRLHSYMLSRKIAELRHRTIQLHREIVLMSKY-------------------SSTEIQKEDLQLGIPPSFMRFQARQREEILEWEFLTGKYLYSATEGQPPRRGMDSAQREALDDIVLQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFVEHEGLDAQELADRINQDSGSLSFLSNSLKKLVP-FQLPGSKMEHKEPKEKKINILIPLSGRFDMFVRFMGNFEKTCLIPNLNVKLVILLFNSDSNPDKAKQVELMRDYRVKYPKADMQVLPVSGGFSRALALEVGS--SQFSNESLLFFCDVDLVFTAEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDN---HFAFTQKTGFWRNYGFGITCIYKGDLVR--VGGFDVSIQGWGLEDVDLFNKVVQAG--------------------------LKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCLGSKASTFGSTQQLAEMWLEKND-----PSYSRGG--NGSARTV-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6ZQ11-1", "uniprot_id": "CHSS1_MOUSE", "id": "Q6ZQ11-1", "name": "Chondroitin sulfate synthase 1", "aln": "---MAARGRRAWLSMLLGLVLGFVLASRLVLPRASELKRVGPRRRPSPEGCRPGQEAS-QPGGARGDARGAQLWPQGSAAEGVPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVEFFSSEGSDTSIPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLESFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENFCMGGPGVILSREVLRRMAPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHSSKIHRAITLHPNKNPPYQYRLHSYMLSRKIAELRHRTIQLHREIVLMSKY-------------------SSTEIQKEDLQLGIPPSFMRFQARQREEILEWEFLTGKYLYSATDGQPPRRGMDSAQREALDDIVMQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKMQFVEHEELDAQELADRINQDSGSLSFLSNSLKKLVA-FQLPGSKTEHKEPKEKKINILIPLSGRFDMFVRFMGNFEKTCLIPNLNVKLVILLFNSDSNPDKAKQVELMRDYRVKYPKADMQVLPVSGGFSRALALEVGS--SQFNNESLLFFCDVDLVFTAEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDN---HFAFTQKTGFWRNYGFGITCIYKGDLVR--VGGFDVSIQGWGLEDVDLFNKVVQAG--------------------------LKTFRSQEVGVVHIHHPVVCDPNLDPKQYKMCLGSKASTFGSTQQLAEMWLEKND-----PSYSKGGS-HGSARTA-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86X52-1", "uniprot_id": "CHSS1_HUMAN", "id": "Q86X52-1", "name": "Chondroitin sulfate synthase 1", "aln": "---MAARGRRAWLSVLLGLVLGFVLASRLVLPRASELKRAGPRRRASPEGCRSGQAAASQAGGARGDARGAQLWPPGSDPDGGPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVQFFSSEGSDTSVPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLENFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENFCMGGPGVIMSREVLRRMVPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHNSKIHQAITLHPNKNPPYQYRLHSYMLSRKISELRHRTIQLHREIVLMSKY-------------------SNTEIHKEDLQLGIPPSFMRFQPRQREEILEWEFLTGKYLYSAVDGQPPRRGMDSAQREALDDIVMQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFVEHEELDAQELAKRINQESGSLSFLSNSLKKLVP-FQLPGSKSEHKEPKDKKINILIPLSGRFDMFVRFMGNFEKTCLIPNQNVKLVVLLFNSDSNPDKAKQVELMRDYRIKYPKADMQILPVSGEFSRALALEVGS--SQFNNESLLFFCDVDLVFTTEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDN---HFAFTQKTGFWRNYGFGITCIYKGDLVR--VGGFDVSIQGWGLEDVDLFNKVVQAG--------------------------LKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCLGSKASTYGSTQQLAEMWLEKND-----PSYSKSSNNNGSVRTA-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7KUZ9-1", "uniprot_id": "Q7KUZ9_DROME", "id": "Q7KUZ9-1", "name": "Hexosyltransferase", "aln": "MLQHTMTKRKTLIIGFFGIALGLCIGTMLKNYLALEIVKRCSLR----------------PTNLKTPADIIGLRDEDTIQNS---QRNLVFVGVMTAKSFLEGRARAVYDTWGKEVPGRMAFFSSEGS-YSDDLPVVGLKNVDDRYPPQKKSFMMLYYMYEHYIDRFEWFIRADDDVYMEPDKLERFLRSIDSSKPQFIGQAGKGNSEEFGLLSLEFDENFCMGGPGVILSSETLRRVAPHIPSCLKNLYSTHEDVEVGRCVQKFAGIPCTWNYEMQYILRHNS-SGRNAYTGKLKRKEIHNAITLHPIKQAPLMYRLHSYVQGLKAEEMRQESLLLHRDIKRMAKYLEVPDESTYMLPSVSPESDSTKRHFQDHNILGISPELNKFVPASTDDLLDWSFIA-RSLYSASSANPKQK-IDSAMREGLEDAITEVMENINNYSRQRGRVIEFRELLYGYHRLDALHGQDMILDLLLIYKKYRGKKMTVPVRRHLYVQRAFTGIFVKEVD----EDFYNVTLQQSLLGSLFQNGMARLSSHFTMPSG---LLSPTQDKIVFVLPIAGRLGTFERFLRTYERVCVRGEQHCDLLVVIFGSPD--ELGDHLQLLHDLHARHVYQQVNWIQRSSAFSRGVALDVAARSSYIRQEDIILFIDVDMVFEVETLQRVRMHTQRGKQVYLPIVFSQYDPQRRSGDAGGSEDEGETPRIDDERGYFRQFGFGICAIYKSDILDEDINGFDKDITGWGLEDVKFLEKIVRVGTRQRGFLANTAELAMDYNEAAEQWRRLSVFRAPDPTLVHIYHDISCDVQLDAPQYNMCLGTKANSLGSTRLMEQLFHSSPENVQFAADFNRQKQQQQQQQQAR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *:: : ::*:.**: :.: * * *: : . * . . * * .: :. :**::*******:.:*: ** *.* **.* :**:: ******* * :*** *:.*** *********** **::**:*::***:*******:: *:** ****::**:* *:**:* *.:**:* *:** .***********:* *.***:.*** .**:::*:***********::***: *.*.**** :: .* ..::.* .*: .:**.****** *:.* ******: . * *:*:.:: ***:* *:** *... ::. ***.*.: :* . . :::*:*.*:: : **** ..:* :: :*** **.*:* : :*** ** :: ***:*:*:*: ***:*::.::* : ******:***::*********** *:*::*: : . * : ::: . *:* *::.*.: :* . * :*.. .*.:.** :::*::**:. * **: .:*:.*: : : .*::::*.* . : ..:::*::* : :: ::: : *. ***.:**:*.: * : :*.:::* ***:** .* *** * :* *:*:*:**:******: .. *:: : :: *::*::**** .***.*:: :.*** .* *******.:::*:*:.* *..**: : :**::* : ** :**. **:****:**.: ***: : ::: .. : ..:.: : . : . ", "identical_positions": 324, "similar_positions": 278, "identity": "37.5%" }, { "cls_id": "homologset.agr.HGNC:17199", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R5D7-1", "uniprot_id": "M0R5D7_RAT", "id": "M0R5D7-1", "name": "", "aln": "MMLNWKLLGLLVLCLFAGGISGS-DDPSPKSTDTQEE-NSPPLPLGPPIPGDPWPGAPPLFDEPPPPGSNRPWRDLPDSGAWPPKPPSTDPPKPPLPDDPWPAGTQPPENPWPPAPEMDSESQEEPDLDPPREEYR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80ZC9-1", "uniprot_id": "PS1C2_MOUSE", "id": "Q80ZC9-1", "name": "Psoriasis susceptibility 1 candidate gene 2 protein homolog", "aln": "-MLTWKLLGLLVLCLCAGGISGN-GDPSPGSTDTHEEEDSPPLPLGPPIPGDPWPGAPPLFDEPPPPGSNRPWRDLPDSGAWPPKPPSTDPPKPPLPDDPWPAGTQPPENPWPPAPEMDHESQEEPDLDPPQEEYR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UIG4-1", "uniprot_id": "PS1C2_HUMAN", "id": "Q9UIG4-1", "name": "Psoriasis susceptibility 1 candidate gene 2 protein", "aln": "MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPLFEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDNRPQEEPDLDPPREEYR", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*.*****:***** : ****. ..** .:: :** .**.** ***:************::***. ..*******::*.* *:** ****:** ********.************:* ..*********:****", "identical_positions": 93, "similar_positions": 29, "identity": "68.38%" }, { "cls_id": "homologset.agr.HGNC:172", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P80202-1", "uniprot_id": "ACV1B_RAT", "id": "P80202-1", "name": "Activin receptor type-1B", "aln": "--------------------------------------------------------------------------------------------MAESAGAS-SFFP--LVVLLLAGSGGSGPRGIQALLCACTS--CLQTNYTCETDGACMVSIFNLDGME-HHVRTCIPKVELVPAGKPFYCLS---------SEDLRNTHCCYID--FCNKIDLRVPSGHLK------------EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCE-MCLSKDKTLQDLVYDLSTSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61271-1", "uniprot_id": "ACV1B_MOUSE", "id": "Q61271-1", "name": "Activin receptor type-1B", "aln": "--------------------------------------------------------------------------------------------MAESAGAS-SFFP--LVVLLLAGSGGSGPRGIQALLCACTS--CLQTNYTCETDGACMVSIFNLDGVE-HHVRTCIPKVELVPAGKPFYCLS---------SEDLRNTHCCYID--FCNKIDLRVPSGHLK------------EPAHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCE-MCLSKDKTLQDLVYDLSTSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P36896-1", "uniprot_id": "ACV1B_HUMAN", "id": "P36896-1", "name": "Activin receptor type-1B", "aln": "--------------------------------------------------------------------------------------------MAESAGAS-SFFP--LVVLLLAGSGGSGPRGVQALLCACTS--CLQANYTCETDGACMVSIFNLDGME-HHVRTCIPKVELVPAGKPFYCLS---------SEDLRNTHCCYTD--YCNRIDLRVPSGHLK------------EPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCE-MCLSKDKTLQDLVYDLSTSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B949-1", "uniprot_id": "A0A8M2B949_DANRE", "id": "A0A8M2B949-1", "name": "Activin receptor type-1C", "aln": "--------------------------------------------------------------------------------------------MLRDGNVA-VMPPRRTAVALLALCGLLAVG--DALKCNCTA--CESTGYVCETDGACMASTSYINGQEEQQVRICIPRVSLVPPGQPIYCLS---------AKGLLNTHCCYTD--FCNSINLQIPNGSSTGQTQYLSNVWGIADGKGGSWGPVELVAVIAGPVFLFCLLLIVGVLLFQHHQRNYNHRQRLDVEDPSCDHLYLAKDKTLQDLIFDLSTSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIEGMIKLSLSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNAGGIHEDYQLPYYDLVPSDPSIEEMRKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLSVQEDIKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1QZF0-1", "uniprot_id": "F1QZF0_DANRE", "id": "F1QZF0-1", "name": "receptor protein serine/threonine kinase", "aln": "------------------------------------------------------------------------------------------------------MDPRQILRILIVLSGLNGVC--DALLCNCTAPHCERDGFKCETNGACVASTSVIEGQE-QHVRLCIHKEKLVPPGQPFYCLS---------AEGLMNTHCCYTD--YCNSIDLRLPIVTNG-------------PGAGQDWGPVELTAVVAGPVFVLCVLVLLGLFLFQHHQRAYGHRQRLEVEDPSTEHMFLAKDKTLQDLIYDLSTSGSG-SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHENGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNCTCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPEVLEESINMRHFDSFKCADIYALGLVYWEIARRCNAGGIHEEYQLPYYDLVPSDPSIEEMRKVVCDQRLRPNIPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLSVDEDLKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z7L8-1", "uniprot_id": "TGFR1_DROME", "id": "A1Z7L8-1", "name": "Receptor protein serine/threonine kinase babo", "aln": "MLSALRLIFLGALLGASVCASPIEFVMDTSLNGSRSDPATATHPGKWPPTTKAPALRAPAGTAGHAYQSPSSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDT--CKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEE-GRQISVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGR-TFAKEDSAYD-PILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVEDKVKN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * : . . : : * * : * . ***:* *..* .. . *: : .:.*.*:.::* . . . .:*.* * :** : . . *:..:: *..:.: . : ::* * : **.: : * :.*::*:: :::***** :****:***::** : * .:************:*** :*********** ***********:***************************:****:*******. :.* : *::::** *:*******:*:**:***.**************.* ***.******** .*::**...:*************:*::* :****:* **:**:**: ******** * ::::*******:* .*******:**** :: ***:** *:: :.*: *.*:*:****.* .************:.:**::.:* ", "identical_positions": 249, "similar_positions": 130, "identity": "39.65%" }, { "cls_id": "homologset.agr.HGNC:1720", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F7FE70-1", "uniprot_id": "F7FE70_RAT", "id": "F7FE70-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEYQQALDILD--MEEPINRRLFEKYLKDDSG----SKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLPLSKLCAEEQ-ELLRFVFENKLKKYNK---------------------------------PSETVIP-----------------------------------------------------------------------QSVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSAVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIG---NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYI--DIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLENATKTPESRPSLEET-FEIEMNESDMMLETSMSDHST", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R349-1", "uniprot_id": "CDC16_MOUSE", "id": "Q8R349-1", "name": "Cell division cycle protein 16 homolog", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILD--MEEPINRRLFEKYLKDDNG----SRDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLPLNKLCAEEQ-ELLRFVFENKLKKYNK---------------------------------PSETVIP-----------------------------------------------------------------------ESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIG---NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLQNSTKAPESRPNLEET-FEIEMNESDMMLETSMSDHST", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13042-1", "uniprot_id": "CDC16_HUMAN", "id": "Q13042-1", "name": "Cell division cycle protein 16 homolog", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD--MEEPINKRLFEKYLKDESG----FKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQ-ELLRFLFENKLKKYNK---------------------------------PSETVIP-----------------------------------------------------------------------ESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIG---NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEET-FEIEMNESDMMLETSMSDHST", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N844-1", "uniprot_id": "A0A8M1N844_DANRE", "id": "A0A8M1N844-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLDRLRKRVRHYIDQQQYQSALFWADKIASLSHEDPQDIYWLAQCLYLTAQYHRASHALRSRKLDKLYGACQYLAARCHYAAKEYQQALDILD--MEEAASKKLLDKNLKEENG----SREIVKDWEMSPASINSSICLLRGKIYDAMDNRPLATSSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKDFLDSLPLSQQCTEEEVELLHFLFENKLKKYNK---------------------------------PSEMVVP-----------------------------------------------------------------------DIVNGLQDNLDVVVSLAERHYYNCDFKMCYSLTSMVMVKDPFHANCLPVHIGTLVELSKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLERTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNPKLAEHFFSQALSIAPEDPFVIHEVAVVAFQNGDYKTSEKLFLDAMEKIKAIG---NEVTVDKWEPLLNNLGHVCRKLKKYEQALEYHRQALVLIPQNASTYSAIGYVHSLKGDFESAIDYFHTALGLKRDDTFSVTMLGHCIEMYISDSDAYIGTDIKDKVRKTLNTPALMKMLNTSAD------GNESRAQPVEEVNVCIETPSFNADKQTDAFQRFLLECDMHESDMMLETSMSDTST", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VCN6-1", "uniprot_id": "Q9VCN6_DROME", "id": "Q9VCN6-1", "name": "", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPGDTENTSTDTTNEHIDLALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEYHRAAHTIQHHKLEKNSLPCFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENHRNELLSSIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQHEMLMAWEEFELMHHLPLAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDTDTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACLVENGDFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIG-KSDPARRYLSKATALDRLYGPAWLAYGHSFANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFINLGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDS-----ATIDEICSAALRDVAKNITAN-----------------------SRRVLNSDKFNGMKLKFDEE-EEFANSDSNMVVEMSFDT---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P09798-1", "uniprot_id": "CDC16_YEAST", "id": "P09798-1", "name": "Anaphase-promoting complex subunit CDC16", "aln": "MKFCLYCCHCYIVICGKATHYYKSSKATSNLKSSNRVLMRNPMSPSEQHSQHNSTLAASPFVSNVSAARTQQSLPTDAQNDRLQQPWNRTNTATSPYQSLANSPLIQKLQANIMTPHQPSANSNSNSNSITGNVVNDNNLLASMSKNSMFGSTIPSTLRKVSLQREYKDSVDGVVRDEDNDEDVHNNGDAAANANNDRESKLGHNGPLTTTTLTTTTTATQLDVSELSAIERLRLWRFDALMQHMYRTAEYIADKVYNISN-DPDDAFWLGQVYYNNNQYVRAVELITRNNLDGVNILCRYLLGLSFVKLQRFDDALDVIGEYNPFSEDPSTTAANTMSNNG---NNSNTSQPVTDGGIKMESSLCFLRGKIYFAQNNFNKARDAFREAILVDIKNFEAFEMLLSKNLLTPQEEWDLFDSLDFKEFGEDKE--IMKNLYKINLSKYIN---------------------------------TEDITKSN-------------------------------------------------------------------EILAKDYKLADNVDVVRSKVDICYTQCKFNECLELCETVLENDEFNTNILPAYIGCLYELSNKNKLFLLSHRLAETFPKSAITWFSVATYYMSLD-RISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYLKKALEVVKDLD-----PSSRTTISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALELNVTLSLDASHPLIDKSNLMSQASKDKASLNKKRSS------LTYDPVNMAKRLRTQKEIFDQNNKALRKGGHDSKTGSNNADDDFDADMELE----", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . : : * :* : *:*: :. :* * :: .* * :* ** . : .:*: * * . :.. :* ::: ..* . .: **: :::**:* * :* * : :*: .: ***:: * .:.:* . ** :::. * : : : : :: ::: .*.** : ..: . : . *:: : .: : :*.:: * .: . :: * *: . *. *. * * .. *.** ::*:*.: :*...::*::*. ** :. : . *::* **:: *: :..**:.:.*::* *.*::**::** .*:::: * *** *::*:: :. :*** :* * .*.* * *::*:.*: :: : : . : ::: :* .: **** **::: *: .: .* :.. : ::*::: .:: *:: :*.:* *. : : ::* .:* : * *.. : : . :.:: : .:. ", "identical_positions": 107, "similar_positions": 209, "identity": "11.12%" }, { "cls_id": "homologset.agr.HGNC:17200", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESY6-1", "uniprot_id": "LRRN3_RAT", "id": "Q9ESY6-1", "name": "Leucine-rich repeat neuronal protein 3", "aln": "MKDAPLQIHVLLGLAITALVQAGDKKVDCPQLCTCEIRPWFTPRSIYMEASTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSAISPGAFVGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDNPILRIKDMNFQPLLKLRSLVIAGINLTEVPDDALVGLENLESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSILDVEADSYVSLHCRATAEPQPEIYWITPSGKRLLPNTLREKFYVHSEGTLDIRGITPKEGGLYTCIATNLVGADLKSIMIKVGGFVPQDNNGSLNIKIRDIRANSVLVSWKANSKILKSSVKWTAFVKTEDSQAAQSARIPSDVKVYNLTHLKPSTEYKICIDIPTIYQKSRKQCVNVTTKSLEHDGKENGKS-HTVFVACVGGLLGIIGVMCLFGCVSQEGNCENEHSYTVNHCHKPTLAFSELYPPLINLWESSKEKPASLEVKATAIGVPTSMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CBC6-1", "uniprot_id": "LRRN3_MOUSE", "id": "Q8CBC6-1", "name": "Leucine-rich repeat neuronal protein 3", "aln": "MKDTPLQVHVLLGLAITTLVQAIDKKVDCPQLCTCEIRPWFTPRSIYMEASTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSQWFDALPNLEILMLGDNPIIRIKDMNFQPLVKLRSLVIAGINLTEIPDDALAGLENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNTNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSDLDVEADSYVSLHCRATAEPQPEIYWITPSGKKLLPNTMREKFYVHSEGTLEIRGITPKEGGLYTCIATNLVGADLKSIMIKVGGSVPQDNNGSLNIKIRDIRANSVLVSWKASSKILKSSVKWTAFVKTEDSHAAQSARIPFDVKVYNLTHLKPSTEYKICIDIPTVYQKSRKQCVNVTTKSLEHDGKEYGKN-HTVFVACVGGLLGIIGVMCLFSCVSQEGSSEGEHSYAVNHCHKPALAFSELYPPLINLWESSKEKRATLEVKATAIGVPTNMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3W5-1", "uniprot_id": "LRRN3_HUMAN", "id": "Q9H3W5-1", "name": "Leucine-rich repeat neuronal protein 3", "aln": "MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q8D1-1", "uniprot_id": "A0A8M9Q8D1_DANRE", "id": "A0A8M9Q8D1-1", "name": "", "aln": "MKDLLFAVCLLAGLALTNSVQASKWSVVCLKLCKCEIRPWFSPLSMYNEAPTVDCNDLGLLTLPERLPSDTQVLLSQANSIAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQLLSLHLEENWLSSLHDNFLAHFPNLQELYVNHNLLSLISAEAFQGLNKLLRLHLNSNQLRAIRSEWFQDLSQLEILMIGENPIARIQNMNFKPLINLRSLVLTRMNLTEIPDSALVGLDKLESVSFYDNMFPKVPQAALRQVRNLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELVSIDSFALHNLPELTKIEATNNPRLSYIHPNAFSQLPRLESLMLNSNALRALHHITVESLPNLQEVSIHSNPIYCDCVIRWINMNNTRVRFMELDALLCAGPSEFEGRLVKQVHSREMADICLPLISPESLPDQVNVGTGHLVSLHCRAFADPEPEIYWVTPSGEKILPQMDSKKYHLHPEGTFDIYGITENEAGQYTCVAHNLIGVDMRSVLVIVNGYYPLLVNESLHIQVENTEPNSVSISWVPPKGSLVSNIKWS--TNSQHHSLQFTSHVVSNVKKFNLTNLHSLTQYEVCVEITDMQSRHLKNCINVTTTEVSKRKNDDVIN-DGLIISLTAVLLIMSAVACSFICMLRR----NDPLYRKLRNQQ-----SEILPSHIKPNWRSRAKANDSETDLTKNSI-----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** : : :* ***:* *** . .* * :**.*******:* *:* **.**********.:* ***::**:** *:*.**:*: . *: **** :***:**:**:::* : ::.****::**** *:.* :: * :.******:****** **. ** **::*********:*: *.*:**: *.:*****:*:*** **::***:**::*****:: :****:**.**.**::***:***** : ***:.**::. ************:**:**** :*:********.****:****:*:.***:* ****************** :**:*******:*** **:* *:******:*:******* *******:***:*.:**** *:*:*..*.**:*: *:*** *:* :******:***:*. ::* :. **:**** *:*:*****:****:::**: .*:::*.***::* *:* :*.* ***:* **:*.*::*::: *.* * * **:*::.: ..*** :** . . * *.:**: .:::. :::: :** :***:*:. *:*::*::*. : .: *:*:****. : :: . ::: . ** : .* * : *: . . * :: .*: *. *: .: * :.. * .: ", "identical_positions": 359, "similar_positions": 204, "identity": "50.71%" }, { "cls_id": "homologset.agr.HGNC:17205", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZKI8-1", "uniprot_id": "D3ZKI8_RAT", "id": "D3ZKI8-1", "name": "", "aln": "---------------------------MGRVGAG-STARVAAAGSLLLLLLLLARPPPAAARNIKESEAGLVSEHFSQAP-----------QKLSFYSWYGSTRLFHFRVPPDTVLLRWLLHVS-----QGGPSCADVEITVHFRYGAPPVINPLGTSFPDDTLTHASFHIKTLLSTMLLGNTS-VNISHPAPGDWFLVAHLPPSS---QKIQVKGFVPTCAYIFQPDMLVMRVVEVSILEPD-----------------------IPLPQTLLSHPS----------------------------------------YLKIFVPEYT---QELRLELQGCVSSVSPGCPVRLT---AGVTTLPRNFQRVLTCTGLAPFCHLLLSSPPWGRWLQVTVESLAEPHVTVGFTAKAAFTACRPWS----VTFHHLIQNNPNQTYDTSAVQLSQSAAHWDLGRSGRSSRVDGGPFCLLNYPVLREDTDVVSVHFQPLNGAFVLVHSNMPSVMQLRLDTGMDSGGSFIIVLRANKSE-------------------------------------VTNGTS-VAACVNVASPFLSFNASLNCTTAFFQGYPMFLSASSHMANLIIPYPETDNWYLSLQLVCP---------------------------ESPEDCEQAAVRVETVLYLVPCLN---------------------------------------------------------------DCGPYGQCLLLRRYGYLYAGCSCKAGWRGWSCTDNSTAQTAAQQRAAALLLTLSNLMFLAPIAISVHRSFLVEASVYFYTMFFSTFYHACDQ-PGEAVLCILSYDTLQYCDFLGSGASTWVTILCMARLKTILKQVLLVLGLLVIAMSLQMDRRGIWNLMGPCVFAFVIMAFMWIYRCGHRRQCYPTSWQRWVFYLLPGISMAFVGIAMYTSMMTSDNYYYTHSIWHILLAGSVAFLLPPREEKAGSWACLQKFPCHYQICRNDRDELYTVT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ESN3-1", "uniprot_id": "PGAP6_MOUSE", "id": "Q9ESN3-1", "name": "Post-GPI attachment to proteins factor 6", "aln": "---------------------------MGRVGAG-GTAREAATGSLLLLLLLLARPPPAAASNSKESEAGLVSEHFSQAP-----------QKLSFYSWYGSTRLFHFRVPPDTVLLRWLLHVS-----QGSPSCTDEEITVHFRYGAPPVINPLGTSFPDNTLSHASFHIRALLSTLMLDNTS-VNISHPAPGDWFLVAHLPPSS---QKIQVKGFVPTCAYIFQPDMLVMRVVEVSTLEPD-----------------------VPLPQTLLSYPS----------------------------------------YLKIFVPEYT---QELRLELQGCVSSVSPGCPVRVT---VGATTLPRNFQRVLTCTGLAPSCHLLLSSPPWGRWLQVTFESLAEPHVTVGFTAKAVFTVCRPWS----VTIHHLIQNNPNQTYDTSAIQLSQSAVHRDLGRS---SRVDSGPFCLLNYPVLREDTDVVSVHFQPLNGAFVLVHSSMPSVMQLRLDTGMDSGGSFIIVLRTNKTE-------------------------------------VTNGTL-VAACVNAASPFLSFNTSLNCTTAFFQGYPMFLRASSHMANLIMPFPETDNWYLSLQLVCP---------------------------ESPEDCEQAVVRVETILYLVPCLN---------------------------------------------------------------DCGPYGQCLLLRRYGYVYAGCSCKAGWRGWSCTDNSTAQTVAQQRAAALLLTLSNLMFLAPIAISLHRSFLVEASVYFYTMFFSTFYHACDQ-PGEAVLCILSYDTLQYCDFLGSGASTWVTILCMARLKTILKQVLLVLGTLVIAMSLQMDRRGIWNLMGPCVFAFVIMASMWIYRCGHRGQCYPTSWQRWVFYLLPGISMASVGIAMYTSMMTSDNYYYTHSIWHILLAGSAAFLLPPREEKAGSWACLQKFPCHYQICRNDRDELYTVT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HCN3-1", "uniprot_id": "PGAP6_HUMAN", "id": "Q9HCN3-1", "name": "Post-GPI attachment to proteins factor 6", "aln": "---------------------------MGRAGTGTGGEAVAAVVAGPLLLLLLARPPPASAGYSGKSEVGLVSEHFSQAP-----------QRLSFYSWYGSARLFRFRVPPDAVLLRWLLQVSR----ESGAACTDAEITVHFRSGAPPVINPLGTSFPDDTAVQPSFQVGVPLSTTPRSNAS-VNVSHPAPGDWFVAAHLPPSS---QKIELKGLAPTCAYVFQPELLVTRVVEISIMEPD-----------------------VPLPQTLLSHPS----------------------------------------YLKVFVPDYT---RELLLELRDCVSNGSLGCPVRLT---VGPVTLPSNFQKVLTCTGAPWPCRLLLPSPPWDRWLQVTAESLVGPLGTVAFSAVAALTACRPRS----VTIQPLLQSSQNQSFNASSGLLSPSPDHQDLGRS---GRVDRSPFCLTNYPVTREDMDVVSVHFQPLDRVSVRVCSDTPSVMRLRLNTGMDSGGSLTISLRANKTE-------------------------------------MRNETV-VVACVNAASPFLGFNTSLNCTTAFFQGYPLSLSAWSRRANLIIPYPETDNWYLSLQLMCP---------------------------ENAEDCEQAVVHVETTLYLVPCLN---------------------------------------------------------------DCGPYGQCLLLRRHSYLYASCSCKAGWRGWSCTDNSTAQTVAQQRAATLLLTLSNLMFLAPIAVSVRRFFLVEASVYAYTMFFSTFYHACDQ-PGEAVLCILSYDTLQYCDFLGSGAAIWVTILCMARLKTVLKYVLFLLGTLVIAMSLQLDRRGMWNMLGPCLFAFVIMASMWAYRCGHRRQCYPTSWQRWAFYLLPGVSMASVGIAIYTSMMTSDNYYYTHSIWHILLAGSAALLLPPPDQPAEPWACSQKFPCHYQICKNDREELYAVT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BI41-1", "uniprot_id": "A0A8M2BI41_DANRE", "id": "A0A8M2BI41-1", "name": "", "aln": "-----------------------------------------MEKYFVLCLLLYATAG------CFADDLTYLNGFYSKTP-----------QRLSKYSWFGNVRLHHFRVPEDAVLVRWLLTVSR----GSGLNCGNQNITVHFRAGAPPVINPIQTAFPNSTSASLAHNLTLIVPSGQSSNVTLFNVTHPKPGDWFLAAHLPKDD---GKIEQQG-LPSCSYLFQAQMFSRRASDLPILQYN-----------------------IPLSQTLTASPA----------------------------------------LFKVFVPEFS---SSLDVFISNCSANVGNDCGLSIT---VGSSTLRQGSEVKQNCSGLK-ICHASVLIPPWNTWLLVTVETNQPNTSVPFYIAANVTVGCKPLSSSSDFNAAAFIRTIIAPQSNSSGVFGNSSTSAKNQSGLR---SNSSEPMCMRSPSVFRDEQDVLSFRYI-VSGNNLTVTSDLPTVLALEHSPG-DSGGTLVVQLQLNTSS-------------------------------------LIGGFARVKACLTPSAPVLQLNRSQTCATGFAQGYTLNVSSSESNALLRIPFPDAENWYLSLQTVCN---------------------------DS-VDCTNASATVSASVSVSACID---------------------------------------------------------------ECGPYGECRLLRTYNYLYGACVCKAGWQGWGCTDGVSALSYSRQMTAALLLTLSNFFFIPPIIVALYRGYLIEAAIYLFTMFFSTFYHACDQ-PGVTVMCIMDYDTLQFCDFLGSVVSVWVTIVCMARLQEPIKYLLFMMGTLVISMAMQLDRRGLWNLLGPVLFALVIMVTSWVYRGVKRHQCYPPLWRRWVLFLLPGIVSALIGVCVYVFAQTDSNYYYTHSIWHVMVATSVVFLLPPREKHVPPWGWTNKI-CSYSRCKNEKVQLYTVT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VBW1-1", "uniprot_id": "Q9VBW1_DROME", "id": "Q9VBW1-1", "name": "EGF-like domain-containing protein", "aln": "MLNSLASHRLFQTGETRGVTITCRNTMIQILTHRPNFSPLVVFMLLLVDHRLIVDSSVPVLQNPSEEYTKYVPIEELKLPEDQELVVRLPSNSLLKYTSYKDVSILHFDVPPDSRTAYFTFKAFEDPKSAFQRKCKPKDVTLHLKASSYPVISPENITFPKNFFTKDQRFKVYDLQFLSDEQQQRITIEGPYIGNWFAVAFVSWSDPNNDRIEQQGLAASCDTLLSAEMSVSRFRPIIINNGQEHEDNLTSHVLPELNGANITKDALNTSRPLRSIPPKQQKLKVASKSLAEGKSSRAAQFANTTENHNSTPTANNEIIYRFYVPDDIGDATARIMFDQVCDECPPVGFHVRANGYPLGGTDHNHGHGTIIRPNQTTEISIQFGVQP--NSWHYALLTFVNEADESEMHSQANNSHTNHSLS--YVLQIDYITEDSDNAMQKSKTVQNSTNSSSANPWEPTKFRRMNFYSLLRQTYREFFMFDYDLRPDVNGTVPETLNLTAKTHSGFAFDLGQVSDIGGTLTFALSMKEAHRASLKMSLPTQPPDLGGILAERLIGDPKEEVVPAVSATSNQSMQIVVCMQLGEPGEPEYPDKCRYGQRLMQASIIVNNTESMGLVHVPFPESGRWYVTMGLFCHGSGTARVSIMESVKEFIRKHQDMLADMRSPCDCAESVARYTSCLQSPDCLEAMNETETLKVKECIMDDKCSTNFKQMTRLFVEHHKAAMEQHVAVENCNTSVVFSVSSSPCVAGRCGRFGRCYHYMSGGFVFSTCVCSKGYRGWDCTEDSQVPTNMSILLATLLLTLSNLLFFPSIYMAVKRRYYTEGVIYFFAMFFSIFYHACDAGEDEYSFCLVKIGVLQFCDFYCGLLSIWVTLVAMAHVRTELVSLLHMFGAILLAFGTELNKQSLWVFLAPALTGICLISTSWGLRCAKSRKLFP-SRRYLSVWLPFGLTLVVAGLVCYAFLQTKQNYHIVHSIWHMVMALSILCLLPSRKSFLPKC------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . . . : : * : * *: : .. : :* ** *: : : . * ::*:*:: .: ***.* :**.. : : ..: * *:** .*.:. .. :*: :* .:* ::..:: * : : : : .:.* : *. :.:**: : * . : . * . . . * . * . . :. * . : . .:. . .. : . .: . : : : :. : : : . * **:: . * : : . : .*: . * . .: : . . : :*:*:: .**::: .* . ** :: . : : *:: ** :*.* .:::. * *. *::**.**:. . : *:*******::*:..* ::: * : *. :* ::**** ****** . :*::. ..**:*** . : ***::.**::: : :* ::* :::::. :::::.:* ::.* : .: :: * * : : :* : .:* *: . *: *. *..**: .*****:::* * ***. .. ", "identical_positions": 118, "similar_positions": 223, "identity": "11.55%" }, { "cls_id": "homologset.agr.HGNC:17206", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9NWH2-1", "uniprot_id": "TM242_HUMAN", "id": "Q9NWH2-1", "name": "Transmembrane protein 242", "aln": "META-GAATGQPASGLEAPGSTNDRLFLVKGGIFLGTVAAAGMLAGFITTLSLAKKKSPEWFNKG-SMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHS--MNDFRSKMQSIFPTIPKN----SES-AVEWEETLKSK--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8VCR3-1", "uniprot_id": "TM242_MOUSE", "id": "Q8VCR3-1", "name": "Transmembrane protein 242", "aln": "METS-GPGPGE-SSELEAPGSPDDRLFLVKGGIFLGSAAAAGMLAGFVTTLSLAKKKSPEWFNKG-TMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHS--MKDFRSKMQSIFPPIPKN----HES-AEEWEEVLKWK--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0L7E8-1", "uniprot_id": "A0ABK0L7E8_RAT", "id": "A0ABK0L7E8-1", "name": "Transmembrane protein 242", "aln": "MEAS-GSGSGE-SSAVEAPGSQDDRLFLIKGGIFLGSAAAAGMLAGFVTTLSLAKKKSPEWFNKG-TMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHSSALHAGPAATPGQPPRWPCP----LSSPVSLIEDVLCWPCHDFSHFK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q4V8S3-1", "uniprot_id": "TM242_DANRE", "id": "Q4V8S3-1", "name": "Transmembrane protein 242", "aln": "MSVEQASASGAVSDIVE-----DDKSHLIKGGAFLATVATAGMIAGFGATLAVAKKKSPDWFNKG-IIGSAAVPESGASLALRALGWGSLYAWCGVGLLSLTIWKAMGVHS--LQEFRQKMQSIFPAIPKNEDAQANSVPFDWNSIFKSK--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VYX5-1", "uniprot_id": "Q9VYX5_DROME", "id": "Q9VYX5-1", "name": "Transmembrane protein 242", "aln": "-----MSEAGTSADAVAAE---KERKFRIQAAAFLGLVGGVSALFGFSRTLATAKKTDSKVLQQAGTRQGMILMDEGATLALRALGWGTLYAVMGTGAFCYGFWKLSGAKD--FQEFRLKMGNALPRITKDEPPASRTDFESLTDLMKYLAAWNKE--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .* :. : .:: . ::.. **. .. .. : ** **: ***.... :::. : :.*::*********:*** *.* :. .** *.:. :: . * . : . : ", "identical_positions": 29, "similar_positions": 48, "identity": "18.35%" }, { "cls_id": "homologset.agr.HGNC:17208", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LEJ2-1", "uniprot_id": "A0ABK0LEJ2_RAT", "id": "A0ABK0LEJ2-1", "name": "", "aln": "MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLINTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDAVTAEPNNDAEALVNGFEHSGLVKAS-LDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVSRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDG--DYYEVDINGPEILSCKYHVAVAEAGELREQLKALHSTHEAREAQLAEEKGRYEAEVQALTEKVSLLEKASHQDQELLAQLEKELRKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAG------RTSPEGRGRRSPVLLPKGLLSTEIGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS---QELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG-------RNKATS---------KAKPATPSCSWFEVLHTNINNSSPMLP--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q921C5-1", "uniprot_id": "BICD2_MOUSE", "id": "Q921C5-1", "name": "Protein bicaudal D homolog 2", "aln": "MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSS-LDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDG--DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAG------RTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS---QELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG-------RSKAAS---------KAKPASPSL--------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TD16-1", "uniprot_id": "BICD2_HUMAN", "id": "Q8TD16-1", "name": "Protein bicaudal D homolog 2", "aln": "MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDD--AAEPNNDAEALVNGFEHGGLAKLP-LDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG--DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS---QELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG-------RAKAAP---------KTKPATPSL--------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AA52Z2I8-1", "uniprot_id": "A0AA52Z2I8_DANRE", "id": "A0AA52Z2I8-1", "name": "", "aln": "MSGDEDGCPGAQLVTEAGPNWLRAEIERLSRELSETSREKIQAAEYGLVVLEENQQLKQRFEELESEYETVRQELDQLREAYGQVHSTHRKVAADGESREESLILESASKEAYYEQRVQELQSDLRQAKNTLTGTQAENERLATLALELRENNEIVELQRSRLRDDIREYKIRESRLLQDYTELEEENISLQKQVSTLKQGQVEFEGLKHENRRLEEEVQYLNSQLEDAIRLREIADRQLTEALETVKTEREQKAALRKELTHHMTLGDSLLAS----SLDGLKLSAD----EPNNDDAILTLENGFAKVCEGNDEDNRLSSPKRDENFRPAPSLVDDLLTELNISEIQKLKQQLLQVEREKVALLTTLQDSQKQLEHARGALAEQQEAMTRLSDDLGAMRRLQAGKERQSALDSERERDSREDNDVDYYELDINGPEILRCKYEVAIAEAGELREELKGLKSEHDEMKTEHEEVRTRLEGHVRDLSIQVSQLEYSSRTDRDKVAKLEKELKEVSAVAGETEGSLSVAQDELVAFSEELANLYHHVCMCNNETPNRVMLDFYKEGKGSKT----------ETKDRQS--------TLTQTNESKGQT-----SRSNSIPVDREEPRPEPMDVYNLVAIIRDQIRHLQKAVDRTTELSRQRVAS---LELAAVADKDQAACMEEILKLKSLLSTKREQIATLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDDMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEFDNEQSRRGSGAGPGGRGKAPSGRGRGPLSFSSPHVSPRLPCKNRPQPHGLIGSPAVFCSEKYKILCDTGSD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P16568-1", "uniprot_id": "BICD_DROME", "id": "P16568-1", "name": "Protein bicaudal D", "aln": "MSSASNNGPSADQSVQD----LQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQEALTKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRMLQENSDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVEFEGAKHEIRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLNRESMYHIS-------NLAYSIR-----SNMEDNASNNSDGEEENLALKRLEADLSTELK-----SPDGTKCDLFSEIHLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDALVQLKKQIDVK---EQGKEGGQKKDE----LEQQLR---ALISQYANWFTLS---AKEIDGLKTDIAELQKGLN-----YTDATTTLRNEVTNLKNKLLATEQKSLDLQSDVQTLTHISQNAGQSLGSARSTLVALSDDLAQLYHLVCTVNGETPTRVLLDHKTDDMSFEN---------------------------DSLTAIQSQFKSDVFIAKPQIVEDLQG-LADSVEIKKYVDTVSDQIKYLKTAVEHTIDMNKHKIRSEGGDALEKVNTEEMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVALTNLKSKYENEKIIVSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEEEKKTLNQLLRLAVQQKLALTQRLEEMEMDREMRHVR-------RPMPAQR--------GTSGKSSFSTRPSSRNPASSNANPF----------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 261, "similar_positions": 254, "identity": "29.66%" }, { "cls_id": "homologset.agr.HGNC:17209", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5Y8C3-1", "uniprot_id": "A0A8I5Y8C3_RAT", "id": "A0A8I5Y8C3-1", "name": "Serine/threonine-protein kinase 36", "aln": "MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEEQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRWPSTITSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSNLGTPFTSRLPPELQVLKDEQ-AHRLAPKGNQSRILRQACKRMAEEAKQKEDQNTGSTLDQEARLSKVTPSTAPVPGLKATPQESSLLAGLLASEMKNNWEDWGAGEAPP------TPRENHITLECEQAFPELRPETMGRRSTDAVDPENEEPDSDDEWQRLLETMEPVPVQLKSPLTLLCNPDFCQHIQSQLRGTGEQILKGVLDGASHLLPALRILSSLLSSCSDSVLLYSFCQEVGLPELPLSLLRYSQESSSIQQQPWYGAFLRELVAVVQAYFSCTFNLERSQTGDSLQVFEEAASLFLDLLGKLLAQPDDSEPTFRRDSLMCFAVLCEAVDGNSRAISKAFYASLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHILCLHLLKVLYSCCYISERLCHILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGRAFLYEEQAWILSHHLLTLEEDSSMSGVCSTRKRKEPSQPIVICGASLCSRMEKLGSEVATLFTHSHIVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPCSCGFYDGLLVLLLQLLTQ--GKPGLIRDVAGSEVWTILWHRFSMALRLSEEVSAQEDDLSLSSPPSLEPDWTLISPQGMAALLSLAMAIFTQEPQLCLSHLSQHGSVLMLTLKHLLSPSFLHRLSQAPQGSEFLPVVVLSVCKLLCFPFALDVDADLLGGILADLRASEVAVYLLQVCCHHLPLFQAELPIGLLTRLALMDPTSLKQFVNTVATSSRAIISFLSVVLLCDQPLMVSDLLSLLTHTTRILSPSHLSFIQELLSGSDESYRPLRSLLGHSENAVRVRTYRLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDAIRRNAASALGNLGPE-GLG-KELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLRQEPCIHQVLVSLGASEKLTLLSLGHQLLPSSNSRPTSARHCRKLIHLLRPTHST", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q69ZM6-1", "uniprot_id": "STK36_MOUSE", "id": "Q69ZM6-1", "name": "Serine/threonine-protein kinase 36", "aln": "MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQVLKDEQ-AHRLAPKGNQSRILRQACKLMAEEAKQKEDQNAGSALEQEDGLCKVTPSTAPVPGLKATPQESSLLAGILASEMKNNWEDWGAGEAPR------TSRENHINLECEQGFPEPRPEAMGRQSTDVVDPENEEPDSDDEWQRLLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSG---------------------------------------------------MEKLGSEVATLFTHSHVVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPYSCGFYDGLLILLLQLLMQVQGKPGLIRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLLSSPSSLEPDWTLISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQGPEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMISDLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPE-GLG-KELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPNSSNRPASVRHCRKLIQLLRPTHST", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NRP7-1", "uniprot_id": "STK36_HUMAN", "id": "Q9NRP7-1", "name": "Serine/threonine-protein kinase 36", "aln": "MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQ-AHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPS------APRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCG---------------------------------------------------MEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTE-QGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPE-GLG-EELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B9P5-1", "uniprot_id": "A0A8M3B9P5_DANRE", "id": "A0A8M3B9P5-1", "name": "non-specific serine/threonine protein kinase", "aln": "MDQYHILEVIGEGSFGRVYKGRRKFSGQVVALKFIPKVGRSEKDLRSLKREIDIMRGLKHPNIVLLLDSFETEREVVVVTEYAEGELFQILEDDGSLPEKQVREIACQLVSALYYLHSHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSVSTLVLTSIKGTPLYMSPELVEEKPYDHSTDLWSLGCILYELHTGAPPFYTNSIFQLVQLIVRDPVKWPDNMSQDCLSFLKGLLMKEPEKRLSWPDLLHHPFVADGVLMVSDEGSS---NPLTVPPSPDVQALKHQQVAEKTTVRSGEGKLLGKARELREKEKTNRREVASGSAARCKTASAGGASNTGHSLGSTFSVYQNSSQPATNRHQANDNSVTRARSAPHKGQISRDYAREFPSVEVGPRQFLKRPGHVRTSLASVRMDSEEQDMDSDYEWQRLVELSDQGPVNAS----------ILQGLKIKLLQAKTQLLVRKGEETSSILLPLKVLRNIVQGCR-IGDVETVGKELELPHLLFSLIEDVLNIPDLMQESQGETVLADLMSVLIMYLEKSPGWEIKGR--------RAEDLCQLFISVFLSGDPKRSALLAAAVLTLFTQRGVSVNVGIEKLTAVLGDVLTYTEAHNPLPAGWGLCDGLLSLILHRLAECESSSLLDFQQSDLWPCLWAKVNIMLQNTPSQSCHFSPNGLYMFLSLALLLFSSDPYTCVTLLSDNTTNCSSTLGHLLTTSCSASLLERGLFWGDSEIN-SLSVMSCHLLCIPFSLDLPLEKHLSVLQSYQSSNIVAG-----------------------------------------------------------LVQMIQTIPIALVELPLCLLNRLLLS---------DPQHTTPCLITAAQASAFLPHGTESSDNGADHTQTQLKHS---GNGVERSKSNGIVKKTKIDHIKGDIKSKKSLDRPTGDVDASRDKN--------SSQNAPSRNIRQTKVKSQAKTYPTKAMEHLRDASKIGHIEELMDSLEIHGSSAGLSPQQGCGISMLIDSLEEFRRSGDRPKTSIR---SSPEEARTAGSLLALLLQSEALSGCAVELLILLSLLTRHPTYQSSFFLPVEFTQ------LRLALLHRDDGIRAACCSLLGHLG-------LCVIRVINEPKFDLFQDLLGCLCDPAPSVRRAACKAVGNWLNEIRKTSDNIPSKGLKSTTDMQTWSVQDKPRRTEGVRYMEADVWMQLAIG-----AARPLVSLLSDADNVIRQHCCGALANLAAF-SGGDGALLNADAPGLILQTACNDSHHAVRRAAVATLRVFSQQNTLLQALRSLDAGRKLCRSSQSSLFQRDYQWLVSKLDGSVEGKT--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P23647-1", "uniprot_id": "FUSED_DROME", "id": "P23647-1", "name": "Serine/threonine-protein kinase fused", "aln": "MNRYAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFIAETQAEAAKESPFTN---PEAKVKSSKQSDPEVGDLDEALAALDFGESRQENLTTSRDSINAIAPS----------------------------------------------------------------------------------------DVEHLETDVEDNMQRVVVP---------------------------FADLSYRDLSGVRAMPMVHQPVINSHTCFVSGNS------------------NMILNHMNDNFDFQASLRGGGVAAKPIVAPTVRQSRSKDLE--------------------------------KRKLSQNLDNFSVRLGHSVDHEAQRKATEIATQEKHNQENKPP----------------------------------------AEAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDS--------------------------------------------CDESQSPPIENDEWLAFLNRSVQELLDG----------------------------------------------------------ELDSLKQHNLVSIIVAPLRNS------------------KAIPRVLKSVAQLLSLP------------------------------------------------------------------------------------FVLVDPVLIVDLELIRNVYVDVKLVPNLMYACKLLLSHKQLSDSAASAPLTTGSLSRTLRSIPELT----------------VEELETACSLYELVCHLVHLQQQFLTQFCDAVAILAASDLFLNFLT----------------------------------------------------------------HDFRQSDSDAASVRLAGCMLALMGCVLRELPENAELVERIVFNPRLN--------------------------------FVSLLQSRHHLLRQRSCQLLRLLARFSLRGVQRIWNGELRFALQQLSEHHSYPALRGEAAQTLDEISHFTFFVT-----------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*::* : .::*:**** ***. :* ..:***:*.*.* **: *:*:.*:** :* * **::: :::***:. ::.***::* :*.: *. :* : *. .: :: :**********:******:****:** *. ******:** *: .* ************:***: *:**** :*:**:*** ** .* *** :.**::**.:* :: *:**..:: .**:*** *:* *:**.:** ***: . : : . . .*:* *: :. . :* . . * . . : .: : .. * *. : * : : *::: : : * :. ::.. ::. : .: . . . : . : . * . : . ::: : : .: : . . : *.: ..: . : .:: * : : :::: . : . :.: * . . * * .* .. : : .: : . ... * : * : . .*. : * * : .:. : : :..** . . :*:. . * *. * : : : : : : .. :: * :* : : : ", "identical_positions": 157, "similar_positions": 216, "identity": "11.41%" }, { "cls_id": "homologset.agr.HGNC:17210", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LZ73-1", "uniprot_id": "A0ABK0LZ73_RAT", "id": "A0ABK0LZ73-1", "name": "", "aln": "-------------------MFGQGRRVGGLKRGRRRSTRPASAPGRTAWARRRPAPPCSPAPPRARSPASARSPRGPPPSATLELIVTTLLHTVEPVGLAKALSWSGPVPFKRLKNRRADKDVLKGVDASNALVLPGRKKKKTKAPPPSKKERKPLTKKERKVLQKVLEQKEKKSQRAELLQKLSEVQVSEAEMSLFYTTAKLGTG--DRMYHIKERK--PDQPAAQGQE----------------------------------------------------------------------KVSSLSGAHR------KRHRSSSTEEDSEASEDSEP---EEVTADQPRTSTGADLVHPPPATSEIKSPVPTPQPPPPGTSAPPET--------------------------------------------PASAPPP-ALAKPAVFIPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDS-----IIGVTEPRRVAAVAMSQRVAKEMNLSHRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLP-------LKLLIMSATLRVEDFTQNQRLFTTPPPVIKVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPIRCSQPQEMEED---SAEGMR------------------RFKKSRTRARKAQA-----MALPQINLDNYSVLPAG-EGDEDREAEMDDEEEALGSDLDLDLGDS-EANEGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVIATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQMKALNIEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQERMKKLQMSQLSCPITALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEEELAELKGRRTRVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYAGCS---PQFCQANGLRYKAMLEIRRLRGQLTTAVNAVCPEAGLFLDPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSEDLLDP----KWKNAYKTPLLDDPVFIHPSSVLFRELPEFVVYQEIVET-----TKMYMKGVSTVEIQWIPSLLPSYCQFDAPLEEPAPTYCPESGRVLCHRASVFYRVGWPLPAVQVDFPEGIDRYKYFARFLLEGQVFRKLASFKSCLLSSPNTMLKTWARLQPR----TETLLRALVAQKADSRDSLLAAWKKNPKYLLAEYCEWLPKAMHGDVEKNWPPTTDR-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IY37-1", "uniprot_id": "DHX37_HUMAN", "id": "Q8IY37-1", "name": "Probable ATP-dependent RNA helicase DHX37", "aln": "--------------------------MGKLRRRYNIKGRQQAGPG------------------------PSKGPPEPPP----------------------------------VQLELEDKDTLKGVDASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTG--NRMYHTKEK---ADEVVAPGQE----------------------------------------------------------------------KISSLSGAHR------KRRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPP--------------------------------------------AAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDS-----IIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLP-------LKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMR------------------KFKKSRARAKKARA-----EVLPQINLDHYSVLPAG-EGDEDREAEVDEEEGALDSDLDLDLGDG-GQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCT---PQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLED----KWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVET-----TKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPR----TESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPDIEKAWPPTTVH-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32TYU1-1", "uniprot_id": "A0AB32TYU1_DANRE", "id": "A0AB32TYU1-1", "name": "RNA helicase", "aln": "MNVSQAADLETLTLLQISVFGCEELAMGRLRKKHNWKGRQQSTSVQ-----------------------TAAADR-QTN----------------------------------VQVEIQDGAVLKGVDDCNALVLPATKTKKQKVERPVTK-KKALTKKQRKNLEKVLEQKDKKAHRAEVLSKLAEVQLPEAELKLLYTTAKLGTG--GKLYHIKESVN-EGQDGGSSSV----------------------------------------------------------------------KISSLSGANR------KRRREADEEEEENESEMSESSEDDDDSEESDSSEEEKEKISEEKHTEEQQQQQVLKEETKPKEADMKEE--------------------------------------------KKAETWTKEDCKPAVFIPVERLPEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGG-----IIGVTEPRRVAAISMSHRVATEMNLSSGVVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIIIDEAHERSVYTDILIGLLSRIVPLRNKKGLP-------MKLIIMSATLRVEDFTENKRLFSSPPPVIKVEARQFAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLRKAFP---YKPNREHTDMMETEEDLK------------------KSKR-----AKKKN-----VSLPRINLDNYSALPVD-EGDEDRQAGID-EDDGEGSDLELELGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHCYRLYSSAVFGD-FSLFSEAEITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEMEKARLSCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVREIFEDYDRPAGSEEENVKMSGKKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLT---PQFCEENGLRFKAMLEIRRLRGQLTNAVNAVCADADVYVDNKMAPPTEAQVLCLRQIVLAGLGDHIARRVQAEELLDP----KWRNAYKTPLLDDPVFIHPSSALHKTLPEFVVYQEIMET-----TKMYMRGVCAVQDDWIPKLLPQYCHFSAPEESPAPRFCPLIGRVKCHQQSTFFRVSWKLPAIEMDYPEGLERYKLFAKFFLEGQVCPKIQKFSSCLLSSPSTMLKTWAKLQPR----TEVLLTALVSEKADNRTSLEAAWRKNEKYLLSAYCQWIPESLHEEVSKIWPPIGQADPR--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O46072-1", "uniprot_id": "KZ_DROME", "id": "O46072-1", "name": "Probable ATP-dependent RNA helicase kurz", "aln": "--------------------------MG--KKVHNAKARQNPQTIVD----------------------NSAVKKIQID------------------------------------VDAVAGGNQVGYDEANALVLPSEK-RATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLA----------------------------------------------------------------------EKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKK--------------------------------------------LKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHK------MIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQP-------LKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLE--DESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALE-------VAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETG--VQRDEDVAPGAN---RFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIKSWSSMNNK----VLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVALSELTPLWPPVDKKEPQRQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04217-1", "uniprot_id": "DHR1_YEAST", "id": "Q04217-1", "name": "Probable ATP-dependent RNA helicase DHR1", "aln": "--------------------------MGTYRKRFNEKARSGHMAKLKELKRIRN---------KQFTRQDENDERVENPDS--------------------------------APAESSTTEPNANAEILEPLTEEEKKMKKRKLQELFTPKESKVSRLKKKRLDKFIEHQLKREERKTIIGKLQDYKIDTS---LLTSSKRLGEGRQTKKEEFKEALSLERQGRGNEQTNEILYEEYEPKVWDEYGEGGSSEDDDGEDDFEASFGSMPKPTDNEEKKSSGFIDHRPAKFGGSGLSFGFSNIKVINKESKTPKKKYNWRQRVEMEELKKHGKEDEMDFDTTSEDDDEEEDQEEEDKMHPSENPLEEVESADSETGSEKFDQNDVANEFKDWANQEIKKLEGRDQELVTPTLNIDYKPIIRKEDLDDGLQEAYVPINENSTRKAFYVEVSRSDEIQKARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRVAAVSMAERVANELGDHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTLFPIAPPVLQVDARQFPVSIHFNRRTA-FNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFPFKKNSKYNKDLETPVSKMGIN---------------------------SKTTD-------LEAEDIDFSVQVIDQDKFKSAIRYEEDEGNSGNGEDEEDEEEEGFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDN---------------KEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQFSKLD---------KFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFLRGKLMEEIVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSD----------------------IPSVIQIKLLKQMICAGFVDH-------VAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLGEMPPKYMLYYSLHLGGNNKTRMNTLCDIASTPLANIARKGLLLTYSKPLTGQGLKTVNLSPTERYCYVVPRFGSTVDNDLKIGWDLNPIAVHQKKQKGQWTVIKFITRKGFQTITGEEKEKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :: . . * . . : :.*. * : * . ::: ::* *: .:::: *: * :: .* : : :: : .* : . : . . : : . ** : . . :. : . : :.:: * * *:*: *::**::.**: :**:: .: *::.**********:********:. ::*:*:******::*:.*** *:. *.* **::.... *::*.*******:*: ** * :*. :*:******.: ****:*:*** * ** * :**:********.**::* ** .**:::*::***.*::**::**. :* * :** ***. ** *.**:*:*** *: : ::**: ** : : . * * ::* : . . * : . .* : : ** ********..::* ::* * * ***:::*********** ::****.*: * * *:. .**.:* * : *:***:**:***** .***********: . *. *. .:* : ***.::***: : :..:::****:**. * * . * ****: :: *: :: **::**:.*** :. :: : * : :*::::* : : : : . . .: : * * . : . .::: : : .: :.. : . . . : .. : : * :.:* : :: . .*.: : :: : : ::. . : . :: .: : * : : . . * : . * . . : . . : : :: . .: * * : : : : . ", "identical_positions": 250, "similar_positions": 290, "identity": "17.54%" }, { "cls_id": "homologset.agr.HGNC:17211", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A321-1", "uniprot_id": "D4A321_RAT", "id": "D4A321-1", "name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "aln": "MEDAGEDASIHRLEGTNLDSQVGGLICKTKSAASEQHVFKAPAPRPSLLGLDLLASLKRREREEKD------DGEDKKKSRISSYKDWEESKDDQKDAEEDGDEQAGRSSRRDRHYRSARVETPSHPGGVSEEFWERSRQRE-RDRREHGVYASSKEDKDRKKEKSRDRDHDRKRDRADERDRSRHSSRS-------ERDGGSERSSRRNEPESPRHRPKDAATP-------SRSTWEEEDSGYGSSRRSQWETPSPTPSYRDSERSHRPSTRDRDRSVRSKSSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREDGEEGIAFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERRKAQHKHWELAGTKLGDIMGVKKEEEPD--KAMTEDGKVDYRTEQKFADHMKEK-SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHQDGYT-DYG-MIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCT-SENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDADKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLS--GAPGDILIFMPGQEDIEVTSDQIVEHLEELEN----------APALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLL-QFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVK---------QAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q92620-1", "uniprot_id": "PRP16_HUMAN", "id": "Q92620-1", "name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "aln": "MGDTSEDASIHRLEGTDLDCQVGGLICKSKSAASEQHVFKAPAPRPSLLGLDLLASLKRREREEKD------DGEDKKKSKVSSYKDWEESKDDQKDAEEEGGDQAGQNIRKDRHYRSARVETPSHPGGVSEEFWERSRQRE-RERREHGVYASSKEEKDWKKEKSRDRDYDRKRDR-DERDRSRHSSRS-------ERDGGSERSSRRNEPESPRHRPKDAATP-------SRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTKLGDIMGVKKEEEPD--KAVTEDGKVDYRTEQKFADHMKRK-SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYT-DYG-MIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCT-SENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLS--GAPGDILIFMPGQEDIEVTSDQIVEHLEELEN----------APALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLL-QFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVK---------QAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VY54-1", "uniprot_id": "Q9VY54_DROME", "id": "Q9VY54-1", "name": "RNA helicase", "aln": "MSDD-DESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFKVPQGSMLGLDKLAAKRRAEKERSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRG--QLREHKDDTPSHTGGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFGQ-RKSDWDMPTPR---RHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATP----------WGED------PESLDLWEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYS-KRG-MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCT-SERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLT--PNEGDMLIFMPGQEDIEVTCEVLEERLAEIDN----------APALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLL-QFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVK---------ESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQ-LATKQEIATPGN------ATPRRTPARIGL-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P15938-1", "uniprot_id": "PRP16_YEAST", "id": "P15938-1", "name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "aln": "-------------MGHSGREERIKDIFKELTSK--------ELTPGLLLTLQKLAQK--------------------------PNTNLEQFIASCKALTKLSSNNPIIFNELLELLKNKSEEDSTGPKKIAPSINKRKKFKIQLDLDDN----EDELDSPVQKKPAPTRTLFKRIDKLKAKQLRQYSPTVK------DPSPNSEQQTQNGHAETKDYEP-------------TRSEVVEED--------------------------------------------------------------------------------------------------------REWYDNDDDYGN-------------LVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALS-MVNPFRNPDSEFSANAKRGSKLVALRRINMEHIQQSRDNTTVLNTAMGEVLGLEN------------NNKAKDKSNQKICD-------DTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKSQKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVYHELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKNDQEATTTGLFGEHYEHTLDKVEDDIDINIRRCKDMRDSVIQELKMTDNSNKEDKKQKTKKQNILNGKENSMKPFKRRKPFF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : . . :* *: ** . : : . : : . :. . :. : .: . :: . :* : : : .:. * : *: :: :: : . . ::. .. .* : * :.* :** *:** *:.*.: * . . :: . *: :.*: : :: . : :. * .. . :: . :: .: : .: . * *.::. *::: *::** * * : *: : .:.: : .* :*:::*::. ..*.. :.:**:.* . *. * . :. **:* :.:**.:**:*.:::::***********:***:::**: . * * ********:******: ** **::***:***** * ** * :*::********:* : ** **.:*:********.**:*:*::: ::*** *****:*****::.**::****.* * ********: :::... :****:**.*::::**: **:****.******.* : : *:: :: . : :***** **:*** ****. . ** ::**********:.** :***.**.****:**:**:*:* * ***:***:*********.** .:****: :*::: *:********:*.:******.* * * :* *:* ** :.:*.*:*:**::**:* :* **. * *.:***:*. .::*::: *** *:* ******** :***** *:.*:* *:** .:***** ***: **: **:*: ***.**:: *:: :.*::* ** *: .*.:.: *.* ****::****:.: :***::.*: :**:::**:. :*****:*.*:* * *:*****:**:***: *.*:** ** * * :::.:* :* .. .: : . :: :: .:. *: . . : . . : : * : ", "identical_positions": 382, "similar_positions": 333, "identity": "29.89%" }, { "cls_id": "homologset.agr.HGNC:17213", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9BWP8-1", "uniprot_id": "COL11_HUMAN", "id": "Q9BWP8-1", "name": "Collectin-11", "aln": "--MRGNLALVGVLISLAFLSLLPS------GHPQPAGDDACS---VQILVPGLKGDAGEKGDKGAP--GRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKN--AVAGVRETESKIYLLVKE-EKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q3SXB8-1", "uniprot_id": "COL11_MOUSE", "id": "Q3SXB8-1", "name": "Collectin-11", "aln": "-MMMRDLALAGMLISLAFLSLLPS------GCPQQTTEDACS---VQILVPGLKGDAGEKGDKGAP--GRPGRVGPTGEKGDMGDKGQKGTVGRHGKIGPIGAKGEKGDSGDIGPPGPSGEPGIPCECSQLRKAIGEMDNQVTQLTTELKFIKN--AVAGLRETESKIYLLVKE-EKRYADAQLSCQARGGTLSMPKDEAANGLMASYLAQAGLARVFIGINDLEKEGAFVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFMCEFDKENL--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5U3G1-1", "uniprot_id": "COL11_DANRE", "id": "Q5U3G1-1", "name": "Collectin-11", "aln": "--MVGEKLVAYMLVSVLGLALLRS------VFGQHMPEEPCS---VQILVPGLKGEAGEKGEKGAP--GRPGRVGPTGEQGPPGDKGQKGSPGRYGKMGPTGPKGLKGDMGDPGPKGPNGEPGVPCECAPLRKMIGEMDIQVVQLTNELKFIKN--AVAGIKETDSKVYLLVKE-EKRYREAEVFCQGRGGHLAMPKDAAANRAIAGYVTDAGLSRVYIGINDLEREGHFVYVERSPMTTFSRWREGEPNNAYDDEDCVEMVSSGEWIDVACQLTMYFVCEFDKDTV--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VM16-1", "uniprot_id": "Q9VM16_DROME", "id": "Q9VM16-1", "name": "C-type lectin domain-containing protein", "aln": "MFSSTRIILCAFLLLYPYGSLIEAQEGRRYVCLLSDPPNQCSEYCVSALQPVIDHLSKEQQDWGACEVKLNGSVAKLDKIEDQLTATQIQIEAQQAFLVNNISKAIKTEDLEQKLKDIEGN--QTALSNQLKDGQKRTENQLTAIQKTLSDIERKLVLQRYQQIGSRYFYIEHNLQVNWRTAEQRCIEMGGHLAAFQNAEEYNAIVGQLNKAN---YWLGVNDLAKQGEFISLASGKRATYFKWRKNEPKYNNPTQHCAYVFG-HENIMIVLSCTTDVMHFICQSDSDV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "B7YZU7-1", "uniprot_id": "B7YZU7_DROME", "id": "B7YZU7-1", "name": "", "aln": "MLKSASALLCGLLALNLYGAWAES----DVICPLKDPPSQCGGFCLGVLTPVLNHLT----------ISQNLANSNNSSKANEVLVRQYTMEGQLTALQN------KQLSIEVALDAQGRK--LNVNEQNFTERLNCMEGILSALEKTVLEVKTKIKYLGFEQIGSKYYYIEKVSEKNWSTASKTCRNMGGHLADIKDEADLAAIKANLKEDTH--YWLGINDLDHEGKFLSMPTGKQTTFLKWASGRPSQ-LDTLNCVFLYN-GEMYDYPCHYTFRFICQTEEEDLNV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P62083-1", "uniprot_id": "RS7_RAT", "id": "P62083-1", "name": "Small ribosomal subunit protein eS7", "aln": "-------------------MFSSS---------------------AKIVKP----------------------NGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFS---------GKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFP--------------SEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL----------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * . . : : : . : : . . . : . . . *: :: : .:: : : . . . . : . : ", "identical_positions": 2, "similar_positions": 33, "identity": "0.69%" }, { "cls_id": "homologset.agr.HGNC:17217", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2KB74-1", "uniprot_id": "A0A0G2KB74_RAT", "id": "A0A0G2KB74-1", "name": "", "aln": "MADRG---------CPLEAAPLPAEVLESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQ----------------------------------------------------------------------------------------------------------------------------------------DVHTEAVQAALAKYKER---KMPMPSKRRSALVHS---SVETYTPPDTSSASEDEGSLRRPGRLTS-TLLQSHSGIEPWLDRVIQGSSTSSS--------ASSTSSHPGGRPAAAP--------SASTALAGLTAHAHIDPHSAPPDVTTGLVEHSHFERPQMASVRGVPRGHGRN-MLETADG-----------VPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVD-DFEELLEVQQPDPNQPKPEGEQMAVLKGEPLSVGTSGPPTLLAALQLWGTTQPKAPCLTALDTSGKAICTLTYGKLWSRSLKLAYTLLSKLTSK--NEPLLNPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQHVGFLLGSCGVTLALTTDACQKGLPKAPT-GEVATFKGWPPLAWLVIDGKHLTKPPKDWYP-LAQDTGSRTAYIEYKTSKDGSTVGVTVPHSSLLAQCQALTQVCGYTEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVISIPYALMKVNPLSWIQ--KVCSYKARAALVKSRDMHWSLLAQRGQRDVCLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPP----DLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGASVCVVKVDGVPYLCKTDEIGEICVSSVATGTAYYGLLGITKNVFETVPVTADG--------------VPVSDRPFTRTGLLGFIGPENLVFVVGKLDGLTVVGARRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDSSEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLG-GIHISETKQRFLEGTLHPCNVLMCPHTCVTN-LPKPRQKQP-------------------EVGPASMIVGNLVAGKRIAQASGRELA----HLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTAT-CIQLHKRAERVAAALMEKGRLD----------AGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLSTQAITRLLKSKEAAAAVDVRTWPTILDTDDIPKKKVASIFRPPSPDVLAYLDFSVSTTGILAG------------------VKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGALRMKGVNLS----------------CVRTCMVVAEERPRISLTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTTGPDPTTVYVDMRALRHDRVRLVER---GSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYG------EEALHADHFSARLSFGDTQTI-WARTGYLGFLRRTELTDAS----------------------------------------------------GERHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALD-LVALVTNVVLEEHYLVVGVVVIVDP-GVIPINS------------------RGEKQRMHLRDGFLADQLDPIYVAYNM-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BWT5-1", "uniprot_id": "DIP2A_MOUSE", "id": "Q8BWT5-1", "name": "Disco-interacting protein 2 homolog A", "aln": "MADRG---------CPLEAAPLPAEVLESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQ----------------------------------------------------------------------------------------------------------------------------------------DVHTEAVQAALAKYKER---KMPMPSKRRSALVHS---SVETYTPPDTSSASEDEGSLRRPGRLTS-TLLQSHSGIEPWLDRVIQGSSTSSS--------ASSTSSHPGGRPAAAP--------SASTALAGLTAHAHIDLHSAPPDVTTGLVEHSSYERPQMASVRGIPRGHGRN-VLETADG-----------VPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVD-DFEELLEVQQPDPNQPKPEGDQMAVLKGEPLSVGTNGPLSLLAALQLWGTTQPKAPCLTALDTAGKATCTLTYGKLWSRSLKLAYTLLNKLTSK--NEPLLNPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVTLALTTDACQKGLPKAPT-GEVATFKGWPPLAWLVIDGKHLTRPPKDWYP-LAQDTGSRTAYIEYKTSKEGSTVGVTVSHSSLLAQCQALTQACGYTEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVITIPYALMKVNPLSWIQ--KVCSYKARAALVKSRDMHWSLLAQRGQRDVCLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPP----DLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGASVCVVKVDGAPYLCKTDEIGEICVNSVATGTAYYGLLGITKNTFETVPVTADG--------------VPVSDRPFTRTGLLGFIGPDNLVFVVGKLDGLMVVGVRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLG-GIHISETKQRFLEGTLHPCNVLMCPHTCVTN-LPKPRQKQP-------------------EVGPASMIVGNLVAGKRIAQASGRELA----HLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTAT-CIQLHKRAERVAAALMEKGRLD----------AGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLSTQAITRLLKSKEAAAAVDVRTWPTILDTDDIPKKKVASIFRPPSPDVLAYLDFSVSTTGILAG------------------VKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGALRMKGVNLS----------------CVRTCMVVAEERPRISLTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTTGPDPTTVYVDMRALRHDRVRLVER---GSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYG------EETLHADHFSARLSFGDTQTI-WARTGYLGFLRRTELTDAS----------------------------------------------------GERHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALD-LVALVTNVVLEEHYLVVGVVVIVDP-GVIPINS------------------RGEKQRMHLRDGFLADQLDPIYVAYNM-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14689-1", "uniprot_id": "DIP2A_HUMAN", "id": "Q14689-1", "name": "Disco-interacting protein 2 homolog A", "aln": "MADRG---------CPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQG------------------------------------------------------------------------------------------------IDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKER---KMPMPSKRRSVLVHS---SVETYTPPDTSSASEDEGSLRRPGRLTS-TPLQSHSSVEPWLDRVIQGSSTSSS--------ASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGS-MLETADG-----------VPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVD-DFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSK--NEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVFLALTTDACQKGLPKAQT-GEVAAFKGWPPLSWLVIDGKHLAKPPKDWHP-LAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQ--KVCFYKARAALVKSRDMHWSLLAQRGQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPP----DLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLCKTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGG--------------APIFDRPFTRTGLLGFIGPDNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLG-GIHISETKQRFLEGTLHPCNVLMCPHTCVTN-LPKPRQKQP-------------------EVGPASMIVGNLVAGKRIAQASGRELA----HLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTAT-CVQLHKRAERVAAALMEKGRLS----------VGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSPDVLAYLDFSVSTTGILAG------------------VKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGVLRMKGVNLS----------------CVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVER---GSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYG------EEALHADHFSARLSFGDTQTI-WARTGYLGFLRRTELTDAS----------------------------------------------------GGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALD-LVALVTNVVLEEHYLVVGVVVIVDP-GVIPINS------------------RGEKQRMHLRDGFLADQLDPIYVAYNM-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AVP4-1", "uniprot_id": "A0A8M3AVP4_DANRE", "id": "A0A8M3AVP4-1", "name": "", "aln": "MAERGSGVLMMLLEPPALAMTLPAEVRERLAELELELSEGDITQKGYEKKRGKLLAPYIPQIQG------------------------------------------------------------------------------------------------VDPSLQIDHRIQSSAPAAHPASKHNKPRLANSRDERFRSDLHTEAVQAALAKYKER---KMPMPSKRRSVLVQS---SVEACTPPDTSSASEDEGSLRRTGRFASSSPYAAQASVEHWFNRVIQGSSTSSS--------ASSTSSHPGGRAQHCTN---TSSASAATVLADLMAHTHIDQHCAPPDVTGLLERSLHAERPQVASVRGLPRGYTHSSLMETADGSVRADEEAVDGVPVNSRVSSKIQQLLNTLKRPKRPPLREFFLD-DFEELLDVQHPDPQQPKPEGGEMRPLSGDPPVVSSNRPSSLLGSLHRWGNTQAKSPCLTSLDNTGKPLYTLTYGKLWTRSQKLAFTLLNKLSSR--NEPLLRPGDRVALVFPNNDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGGQQVGFLLGSCGVTLALTTDACQKGLPKAQT-GEVVTFKGWPRLLWFVTDGKHVVKPPKDWHP-PIRDASNEIAYIEYKTGKEGSTMGVTVSHSAMLAHCHALTQACGYTEGEIITNVLDFKRDAGLWHGVLTSVMNRMHVISIPYSLMKVNPLSWIQ--KVHTYKARVAVVKSRDMHWSLLAQRDQRDISLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSSEALTVAIRRPP----ETGVPPPGKAVLSMSGLSYGVIRVDTEEKLSVLTVQDAGQVMPGGLVCVIRVEGTPYLCRTDEVGEICVSSSTTGISYYGLPGMTKNVFETIPVTSSG--------------APISDRAFTRTSLLGFIGPDNLVFVVGKLDGLMVVSGRRHNADDVVATALAVEPMKFVYRGRIAVFSVSVLHDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLG-GIHISESKQRFLEGALHPCNVLMCPHTCVTN-LPKPRQKQPGT-----------------EVGPASMIVGNLVAGKRIAQACGRDVT----QLEDHD---QFLYLQDVLQWRAQATPDHPLFLLLNSKGTVVNTAS-CVQLHKRAERVALALMERGRLN----------AGDHVALLYPPGIDLIATFYGCLYAGCVPVTVRPPHPQNLTTTLPTVKMIVEVSKSVCILTTQAIMKLLKSKEAAAAVDIKAWPLILDTDDLPRKRLPQIYKPPSPEMLAYLDFSVSTTGILAG------------------VKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSILVPPLELETNASLWLSAVSQYKVRVTFCSYSVMEMCTKGLGSQTEALRLRNVNLS----------------CVRTCMVVAEERPRITLTQSFSKIFKDLGLSTRAVSTTFGCRVNVAVCLQGTAGPDPTTVYLDMRALRHDRVRLVER---GSPHSLPLMESGKILPGVKVIIANTETKGPLGDSHLGEVWVSSPHNATGYYTVYG------EEALHADHFNTKLSFGDTQTV-WARTGYLGFLRRTELTDAS----------------------------------------------------GERHDALYVVGALDETLELRGMRYHPIDIETSVIRSHKSIAECAVFTWTNLLVVVVELEGSEQEALD-LVALVTNVVLEEHYLIVGVVVVVDP-GVIPINS------------------RGEKQRMHLRDGFLADQLDPIYVAYNM-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0S9-1", "uniprot_id": "DIP2_DROME", "id": "Q9W0S9-1", "name": "Disco-interacting protein 2", "aln": "---------------MEHTASLPGYVREKLAELDLELSEGDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNSTNHGNINNDGVIVSSEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAPGYENMRPQGGAVGDPGYQNTREPSAFQNQQSTNNSQHRQRRTQRKVTHNEKRYHSEVRQEAVQQALAALKGRPKPSLPMPSKRTSVLNRSPGCNDELDSSTDDESIPEETISPDKEYNYPRDHISNSILPPEPIIKPPIRESSMGSQQHARTDVKQNQITNQKYTAPNSAPERRPPQNLPPLPTSEPLSSDYPPIAYKRENDFSDKAFKQKQYNAPDITQFNNAHRAADRVTRYVNVSQNELN----ETDANGKWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPNAPKPEGSTMTPVQGEQLSIPAGLPRTLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLLSRAQKIAHALSTKIFSKGPEQVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPPQQVGFLLSSCGITVALTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEFNVGNLRADDSAAAYIEYTTDKEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREVGLWHSVLTSVLNGMHVIFIPYALMKLRPSSWMQ--LITKHRASCCLVKSRDLHWGLLATKDHKDISLSSLRMLLVADGANPWSLSSCDQFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSATGRGVLSMAALSHGVVRVDSEDSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEICVTSGSTSASYFGLDGMTNSTFKVQPLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKHNADDIIATVLAVEPMRFIYRGRIAVFSIKVLRDERVCVIAEQRPDCSEEESFQWMSRVLQAVDSIHQVGIYCLALVPPNHLPKTPLG-GIHLCEARRRFLEGSLHPANVLMCPHTCVTN-LPKPRELHQGVQTAAKLSSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVG----LAEDCE--RKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLT-CSELHKRAEKIAALLQERGRIE----------PGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPIIKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGIAT-VSFDSSAYLDFSVSTCGRLSG------------------VNITHRSLSSLCASLKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNIDLR----------------CVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQVYVDMRALRNNRVALVER---GAPNSLCVIESGKLLPGVKVIIANPETKGHCGDSHLGEIWVQAPHNANGYFTIYG------DETDYNDHFNAKLVTGATSEL-YARTGYLGFLRRTECSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNESEALD-LVPLVTNTVLEDHQLIVGVVVVVDP-GVVPINS------------------RGEKQRMHLRDGFLADQLDPIYVAYNM-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12275-1", "uniprot_id": "CRM2_YEAST", "id": "Q12275-1", "name": "Homeostatic regulator of DAG", "aln": "-------------MDFSIPPTLPLDLQSRLNELIQDYKDENLTRKGYETKRKQLLDKFEISQMR---------------------------------------------------------------------------------------------------------------------------PYTPLRSPNSRKSKHLHRRNTSLASSITS----LPNSIDRRHSIYRVTTINSTSANNTPRRRSKRYTASLQSSLPGSSDENGSVKDAVYNPMIPLLPRHTGAEN---------TSSGDSAMTDSLPLILRGRFEHYDGQTAMISINSKGKETFITWDKLYLKAERVAHELNKSHLYKMDKILLWYNKNDVIEFTIA------------LLGCFISGMAAVPVSFETYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTKAKKTSPTFDIPNISYIEFTRTPLGRLSG--VVMKHNILINQFET-----MTKILNSRSMPHWKQKSQSIRKPFHKKIMATNSRFVILNSLDPTRSTGLIMGVLFNLFTGNLMISIDSSILQRP-----GGYENIIDKFRADILLNDQLQLKQVVINYLE-NPESAFSKKHKIDFSCIKSCLTSCTTIDTDVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFINREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISSNHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTKLMGFVHNGKIYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAESTKAIDISSLSG-------ETSSGYKRVVESHYLQQIT-ETVVRTVNTVFEVAAFELQHHKEEHFLVMVVESSLAKTEEES-----KNGETTDTTLMKFAETQRNKLETKMNDLTDQIFRILWIFHKIQPMCILVVPRDTLPRRYCSLELANSTVEKKFLNNDLSAQFVKFQFDNVILDFLPHSAYYNESILSEHLSKLRKMALQEEYAMIEPAYRNGGPVKPKLALQCSGVDYRDESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNASKIVKETLQLRNNSPLFSICSHTSGLGFMFSCLLGIYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQG--------------------------------------------------EVVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTKGISPKNSSMIMEVWAKNRASIMQAWFDQKIQIEAQFGINYGENISIYLLSDYEKDNI", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .** : . * ** : .: ::*:****.** :** : . : . : :** :* . .* : : . . . . * . : : : ... .. . . .. : :. : ..: .. . :*. :. . . * * : . : .. : * : . . .:* : . *:* : . : : . . : :: . :... : .:: :: . * .* . : :*.*:. : :: ::. * * : . :: : :: : :: . . *::. *. . .*: : :. : : * . : . :. :. . : : :: . ::: : .. .:. : .: . . :. : : . ..:. :: . . .:: : . .: : . * . : . . . . . ..: . : : * * . : :. : .: : . .* . . .:. . . . ..: * : :* .. : . ::*: :..:. .: . : .. . * : .** : : * . : .:::: : :*:: *: :** : **: . : . .::**:. * . * : .. : : **:. : : .: *. * : :. * : .. . : :*.** :. * . .. : .: : ::**:.. : * :. ** : :: .:: :. : .*** . : :.: . : . : * : *:: * :: : **...:.. : . * . .: : . .*.... :. *.::* : . :* :* . : . .**** : * .:*:* : *.. :: :: . :* :.: ..: : . .: . . :: : :: **. :: :***: :.: * :. :.* :* : :.* :.::. . .. :*:* :**.. : *: .: : : : :** : ..* :.:.** *..:**:* : ** .*:. . .:. ::*.::: .. : : *** ***::... ::: : ::*:*::.* :.: *: :. *:* :* * .*..* : . .*** ::. . .. *. *..*:.. :*:.* :::.: ..* . *: * ** .:* ::. : *: .: .**: : ", "identical_positions": 154, "similar_positions": 516, "identity": "8.17%" }, { "cls_id": "homologset.agr.HGNC:17218", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VDN4-1", "uniprot_id": "Q9VDN4_DROME", "id": "Q9VDN4-1", "name": "C2H2-type domain-containing protein", "aln": "MHLNHATAATAAMANYQHYQLPASHGGGGGGGGGGGGGGGSNGGSGPGPNSGQQQPTTLASLQQSPFALHQLTAVQAIQHPTHQAMLHPQHPLVHLLDISTTTANSGGGGGGSHTPISPMKQEVQSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQPQTGSGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHTC", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9NSJ1-1", "uniprot_id": "Z355P_HUMAN", "id": "Q9NSJ1-1", "name": "Putative zinc finger protein 355P", "aln": "MRDEVAEKEKADINVTLVFQG-------------------------------YENTPIMVCVDGIVFSKPDLVTCLEQRK-KPWSMKHPGLTQHNIVHTGDKPYKCKDCG-------KIFKWSSNLTIHQR---IHSGEKPYKCEECGKAFKQSSKLNEHMRAHTGEKFYKCEECGKAFKHPSGLTLHKRIHTGENPYKFEECDKAFYWVLSFTKHMIIHRGEKP-----------------YKYQECGKAFKWSSN-LTIHKRIHTG----------EKPCKCEECGKACKQSLGLTIQKRIHTEEKPYKCEECGS-----SNLTIYKKIHAGEKPYNCEKCGKAFYCSSNLIQNNIVHAEEKHY----------------------------KCQECGKAFKKSLDLNVHKIIHSGEKPYRYEECGKITHS----------GEESYKCEECGKGFYCSSSLTKHMIVHTEEKLYKCEECGKAFKWSSELTIHQRIRTEEKPYKCEECVRVFKHSSKLNEHKRNHTGEKPYKCEACGKAF---------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: : * .* : :* ::.. :..:: *: :*.: :: . :* ** . :::. . .. :. . * . :* . : .* :. :.. .* :*. * : *:* :.*.:**: **.*: ***:.*.***:: * ** * :*****:*:. : * * * :: :*: *:. :. :: .: :*:: . : : * * :::* ** :*. * : * * ::* * : ****** *.. :.*: :****:*:***.*. * * .*.* :: .*:.: . * . : :.*. .. :**: ..:* : *. * * * ::. . .* . : : .. :: : *. * : *. .* *. * : :* ******: * *:: :.**:* : *******:*. * * * ", "identical_positions": 118, "similar_positions": 154, "identity": "21.22%" }, { "cls_id": "homologset.agr.HGNC:1722", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P11440-1", "uniprot_id": "CDK1_MOUSE", "id": "P11440-1", "name": "Cyclin-dependent kinase 1", "aln": "----MEDYIKIEKIGEGTYGVVYKGRHRVTGQ---IVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDS-RLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P39951-1", "uniprot_id": "CDK1_RAT", "id": "P39951-1", "name": "Cyclin-dependent kinase 1", "aln": "----MEDYIKIEKIGEGTYGVVYKGRHRTTGQ---IVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDS-RLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P06493-1", "uniprot_id": "CDK1_HUMAN", "id": "P06493-1", "name": "Cyclin-dependent kinase 1", "aln": "----MEDYTKIEKIGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDS-RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P23572-1", "uniprot_id": "CDK1_DROME", "id": "P23572-1", "name": "Cyclin-dependent kinase 1", "aln": "----MEDFEKIEKIGEGTYGVVYKGRNRLTGQ---IVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEEN-RIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P00546-1", "uniprot_id": "CDK1_YEAST", "id": "P00546-1", "name": "Cyclin-dependent kinase 1", "aln": "MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: ::**:**********. . .** :**:*******::*****************:. *** * *:: .: ::**:****.:***:*::.:* .: : :.:*:.:: *: ..* :** :*:************:..* :*:.****.*:**:*:* ****:******:******. :** ** **** ****:..:**:* *******:*::** * **.: :** : * *:* :** * .*:. : .** .*:**:.*:* *** :***.: ****: ", "identical_positions": 155, "similar_positions": 87, "identity": "50.82%" }, { "cls_id": "homologset.agr.HGNC:17223", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZPB6-1", "uniprot_id": "D3ZPB6_RAT", "id": "D3ZPB6-1", "name": "Uronyl 2-sulfotransferase", "aln": "MKKKQQQHPGGGADPWPHGAPVGGAPPCLGSCKRRIPLLPF-LRFSLRDYGFCMATLLVFCLGSLFYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFKLVTSDIHNKTRLTKNEQ----MELIKNISTVEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKRKLGLKSRASRPPLRPQFFIPTPLETEEPIDDEEQDDD---EKWLEDIYKR----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BUB6-1", "uniprot_id": "UST_MOUSE", "id": "Q8BUB6-1", "name": "Uronyl 2-sulfotransferase", "aln": "MKKKQQQHPGGGTDPWPHGAPVGGAPPCLGSCKRRIPLLPF-LRFSLRDYGFCMATLLVFCLGSLFYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHNKTRLTKNEQ----MELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVSRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVRKTVPSPEAVQILYQRMRYEYEFYHYVREQFHLLKRKLGLKSRVSGPPVRPQFFIPTPLETEEPIDDEEQDD----EKWLEDIYKR----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2C2-1", "uniprot_id": "UST_HUMAN", "id": "Q9Y2C2-1", "name": "Uronyl 2-sulfotransferase", "aln": "MKKKQQ-HPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPF-LRFSLRDYGFCMATLLVFCLGSLLYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTSDIHNKTRLTKNEQ----MELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKRKFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDD----EKWLEDIYKR----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AWA0-1", "uniprot_id": "A0A8M3AWA0_DANRE", "id": "A0A8M3AWA0-1", "name": "Uronyl 2-sulfotransferase", "aln": "MKNYSS-----SSRLNNHSASHGTD----RNSRRGFWLSALGLRFSLRDYAFCMATLLLFCLGSLFYQLNGGPPKVLLEIRQYLGESTFVDDHGPPTPRELPFPSQVIYNRVGKCGSRTVVLLLRILAEKHQFNLVSSDIHNKTRLTKHEQVSGWVDLITNISNIPQPFLYTRHVHFLNFTRFRIEQPVYINIIRDPINRFLSNYFFRRFGDWRGEQNHLIRTPQMKDDERYLDINVCIMENYPECSNPRLFYIVPYFCGQHPQCREPGMWAVERAKQNVIENFLLVGILEELEDVLLLLERLLPHYFSDVLTIYKSPAFWKMGNLTGTVKKHMPTIEALQVLYQRMKYEYDFYNFIRDQFHLTKKKIGLKSSSQNSAHEPDFLRELALRTHEPLEEEEEEEEEEDDIGQEDANIWLVQP", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: .. .: *.*. * . :* . * .: ********.*******:******:***.****:.**::*****:**::******..: *******:*******************:*** *:**:***********:** ::**.***. **:*:*********:** :***********:.********************:****.*:::******* **:**************:********:***** **:**** ** *********************:*****..**:***.* . *:**:* **:* :*: **:*:*****:***:**:::::**** *:*:**** . .. .*.*: .*.*.**:::**::: : ** ", "identical_positions": 267, "similar_positions": 88, "identity": "63.57%" }, { "cls_id": "homologset.agr.HGNC:17224", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O75154-1", "uniprot_id": "RFIP3_HUMAN", "id": "O75154-1", "name": "Rab11 family-interacting protein 3", "aln": "--MASAPPASPPGSEPPGP---DPEPG-----GPDGPG-------------AAQLAPGP----AELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGG------PRDP-----------GPSAP------------------------------------PPRSGPRG---------QLASPDAPGPGPRS-----------EAP-------------------LPELDPLFSWTEE---PEE---------------------------------------------CGP-----------------ASCPESAPFR---------------------LQGSSSSHRARGEVD-----------------------------------------------------------------------------VFSPFPAPTAGELALEQGPGS------------------------------------------------------------PPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGD----GFVRIEDFIQFAT-VYGAEQVKDLTKYLDPSGLG-------VISFEDFYQGITAIRNGDPDGQCYGGVASAQ--DEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTS-------TLVHPELQPEGDADSAGGSAVPSECLDAMEEPD---HGALLLLPGRPH-------------PHGQSVI---------TVIGGEE----HFEDYGEGSEAELSP--------------ETLCNGQLGCSDPAFLTPSP-------------------------TKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRAN-ALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDE-------------LMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8CHD8-1", "uniprot_id": "RFIP3_MOUSE", "id": "Q8CHD8-1", "name": "Rab11 family-interacting protein 3", "aln": "--MELCQPTSLSDHDQPAS---GPQRGVMGLVGPDAPRGWSEEPE-----EHAQLQRWPEGPNAPICWPEEVEEPHAPSRWAKEPNAPRCSSQEPDESCHLAEELEESDSPRCWPQEPDTPCHLAKELEEPDAPRCLPQEPDTPCYL---------------AKELEEPNIPRCWPQEPDVPCHLAKELEEPDAPRCWPQEPDAFCHLLKEVEEPDALRCWLQGPDAPCHLAKELEDLDSPRCWPQE---PDESCHLAKELEEPDAPCHL-----------------AKELEEPDAPRCWPQEPDVPCLLAKKWEESDAPCLLTEELEEPDALHCWPQESEAPCLLAKELEEPDASHSCPQEADTGCLSAKEPEEPDVSHLWQGVPDAPCL-LVKEPEEADALHCCWPEESEEPDALNPPCFWANEPDEPDPSRCWSEEPQVLCLWPEEQNTKRCWQEEPDAPCFWPEDREEPIVSCLQFKEPEKPKVRSSWPE--ELEDCCPTRGLPLEPLLADGELLQACPGPPSDPGPALSLPSEPGTAQEEGARLRAVFDALDRDGD----GFVRIEDFIQFAT-VYGAEQVKDLTQYLDPSGLG-------VISFEDFYQGIVAIRNGDPDGQLYS-VEPVQ--DEETPACADEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTS-------TLVHPELQPEGDVDSAGGSGVPSECLDTMEEPD---HGALLLLPGRSR-------------PHSQAVV---------MVIGSEE----HFEDYGEGNEAELSP--------------ETLCDGDG--EDPAFLTPSP-------------------------AKRLSSRKVARYLHQSGTLTMEALEDPPPEPVECPEEDIADKVIFLERRVSELEKDSAAAGEQHGRLRQENLQLVHRAN-ALEEQLKEQEFRAQEKVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKMLDEIEELTQRLSEEQENKRKMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLRLEVEQRRGRSSSLGLQEYNSRARESELEQEVRRLKQDNRNLKEQNDELNGQIITLSIQGAKSLFSTSFSESLAAEISSVSRDE-------------LMEAIQKQEEINFRLQDYIDRIIVAILETNPSILEVK-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7T005-1", "uniprot_id": "RFIP3_DANRE", "id": "Q7T005-1", "name": "Rab11 family-interacting protein 3", "aln": "MEQVLSSPQGCSEWEVNGKTEWESDQNPLGFLLVDKENSSVADPTNEIFQENAINLDDLFWASQTYSWENGLDCVYPEWKAQPPPSQDLKGDGNSGISQLVEGDLICFNSRSASPSLADRPVQDNNLYDHAEQVEVTATSSTLNVCTGELGINAPTLHTDKTLLQDTHLMLEESHLTNCEFSCNSGVENESQNFLSHGTRN--ILESEGLFAVSPVEVSCVDTNSNPKPTIVCQTPPLASEHIYLSSSALPCEPVFPMTCTKPHVPPYHAGSATLPMDEVEMMLPKLQGGEGESSKPSANNRTLEPQRLDANTDTTHLSVCPLGESDISPEHCEEMLHELSTKCTVEMVEEEVNKKSVSSNTTNTAFSKPKTELCEELSGCTLGVLLETVSGDVKEEAASDSRTDHVFPETQTDLAPVALIDSQAEDPSTESLPRKNGQEESKSALPVSTPEHNALFELSSGNVVLPEDHSQSTFSAQTQALSEVDHDGDLTPDGMLTDNIVCEAVTSIDSVILSLTDSFELPKLSDCDLSSHDFESHALTLEIQNNVTCVQTGSVDNNPEEMSTPFTCTDNQLTVTGGLAGLDLTETTSQSGEASGEGEAGLPVLPTHQEDFHQLTPSEINLAQEQQVSSVVPSSPPSHRDVFPCGASLDGEAYLTLMENNPDTLKHAEMTLDLCKASDALPTKSLQIAPVDLIHVPIVSATAPRSEEQSALRAVFQALDQDGDGFVHIEEFIEFAKAYGAEQVKDLTRFLDPSGLGVISFEDFHRGISAISNEESAYSECETFTDEDTTALVHPELHEDVETDSGIENTLTDGDDRNSPSSFPASFQNFLQSEALEFFCTHCHKQISRLEDLSTRLQLLEMNRHLQQS--NNLDVMGDLTQDILDLADRDITDKVLLLEKRVCELEKDSLESEEQHARLRQENLTLVHRAN-ALEEQLKEQELRTEEDLLAQTRKHRDALNKLQRERDLEIENLQARLHQLDEENSELRSCVPCLRANIERLEEEKRKLQDEADDITQRLNEESESRRKMSDKLSHERHTNQKEKECTQGLIEDLRKQLEHLQLFKLETEARRGRSSSNGLQEYNTHMRENELEQEIRRLKQDNRSLKEQNDELNGQIINLSIQGAKSLFTESLSESLAAEINNVSRAE-------------LMEAIHKQEEINFRLQDYIDRIIVAIMESNPSILEVK-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9ND89-1", "uniprot_id": "M9ND89_DROME", "id": "M9ND89-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSQPASQPDSIDLAYDMWAGQFEFVGPTNQQSNKNSNNN-------NNNSNLNNNKCRIGAQQNRKLS----------------TDSLEDLNLSFNTSASQNPLSNAYSLGVTGG--------AGSDYCGFGKHPPILIDQETFLSLNPADFEDIVPSNSEPN-------SLVFIENKLETNNNSLESNNNHINNNNNNKIYN------LENLTSKFN-----------------------------NKTNNTN-----TNGFKLENLKNFKN--------------KLLCDFEDTNSGGGGGGGSG--------------------------------------------GSGPVGMMNGALSAEICDNLNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYH-MLEEQYRESELRAEERLAEEQKRHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHRTEEQLELARDQIGVLQQEHEEQAQALR----RHEQEKKSTEELMLELGRELQRAREESGARAMPTTSPESIRLEELHQEL--EEMRQKNRTLEEQNEELQATMLTNQATMLTNGVEQGRHLLNGTLNS-LAQELEEMSQAQDSVDSATLASLSQLQQAFQEKEDENVRLKHYIDTILLNIVENYPQLLEVKPMERK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9Z2M4-1", "uniprot_id": "DECR2_RAT", "id": "Q9Z2M4-1", "name": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTQQPPDVEE--DDCLSEYHHLFCPDLLQDKVAFITGGGSGIGFRIAEIFMRHGCHTVIVSRSLPRVSEAAKKLVAATGKRCLPLSMDVRVPPAVMAAVDQALKEFGKIDILINCAAGNFLCPASALSFNAFKTVVDIDTLGTFN---------VSRVLYEKFFRDHGGVIVNITATLSMRGQVLQLHAG-AAKAAVDAMTRHLAVEWGPQNIRVNSLAPGAISGTEGLRRLGGPKASSKFKYLSSPIPRLGTKTEIAHSVLYLASPLASYVSG---------------IVLVVDGGSWMTLPNDIGRLLEFESSSAKL----------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : :: : : . : : : : .: .: : : :: * * : :: :. . : . : : : : . * . . .: :: : : . :: . ..: : . * : :. : : . . .: . . * . *. :: .. ", "identical_positions": 6, "similar_positions": 67, "identity": "0.5%" }, { "cls_id": "homologset.agr.HGNC:17228", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6PFE3-1", "uniprot_id": "RA54B_MOUSE", "id": "Q6PFE3-1", "name": "DNA repair and recombination protein RAD54B", "aln": "MRRSAAPSQVQGKSFKKTRFIPPGRSNAD------VSKEITKMSPD--PKLFQGAEQ------SQNDPGVCSSNPCPSEGIPREVGDG--------------TRVDPLPPVHSASKEITESKA-QEEEASSLLKYFSVVWCKASKKKHKKWEGDAILIVRGRSFTLKDLEGKDIGRGIGYKFKDLENVEE-----GQTLIIGGKEIEILGTISSDDFNSGKCFQHGSGSPAVP-SSQAARKCFSNPFKS------VCQSTQA----QGKR--WNDCRPRHNPCTPNALVMPRPDE---NHQRMFNRHCSPIVDVVIDPHLVHHLRPHQKDGIIFLYECVMGMR--------------------AVGKCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKP-----------VIKKTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVDQDHK-------VEEFINST-FHSVLIISYEMLLRSLDQIKT--IPFGLLICDEGHRLKNSSIKTTTALSSLSCEKTVILTGTPVQNDLQEFFALVDFVNPGILGSLSSYRKIYEEPIIISREPS--SSKEERELGERRATELTRLTGRFILRRTQEVINKYLPPKIENVVFCRPGALQIELYRKLLRSQSVRFCLQG--LLENSAHLICIGALKKLCNHPCLLFSSVKGKEFSSSCEENEERNLCQGLLSVFPAGYNPLQFSEEESGKLQVLVKLLAVIHELRPTEKVILVSNYRQTLNVLEEVCKRHGYACARLDGQTPVSQRQHIVDSFNSKYSTDFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKHPVHIYRLLTTGTIEEKIYQRQISKQGLSGAVVDLTRS-----SEHIQFSVEELKNLFTLHESSHCVTHDLLD-CECTGEKGHTEDASEG--------------PVAS-RQCQFGP--QKSDALRP-LSMSQLKQWKHFSGDHLN-----LPDPFLERIRENVSFFFQNITNQAPAV-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y620-1", "uniprot_id": "RA54B_HUMAN", "id": "Q9Y620-1", "name": "DNA repair and recombination protein RAD54B", "aln": "MRRSAAPSQLQGNSFKKPKFIPPGRSNPG------LNEEITKLNPD--IKLFEGVAINNTFLPSQNDLRICSLN-LPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKE-QEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKDIGRGIGYKFKELEKIEE-----GQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKS------VCKPSSK----ENRQNDFQNCKPRHDPYTPNSLVMPRPDK---NHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMR--------------------MNGRCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKP-----------VIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHK-------VEEFIKSI-FYSVLIISYEMLLRSLDQIKN--IKFDLLICDEGHRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPS--ASEEEKELGERRAAELTCLTGLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQG--LLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDKNEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIVDGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVVDLTKT-----SEHIQFSVEELKNLFTLHESSDCVTHDLLD-CECTGEEVHTGDSLEK--------------FIVS-RDCQLGPHHQKSNSLKP-LSMSQLKQWKHFSGDHLN-----LTDPFLERITENVSFIFQNITTQATGT-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E9QHY4-1", "uniprot_id": "E9QHY4_DANRE", "id": "E9QHY4-1", "name": "", "aln": "MRRSGAPSQLRGNAAKKPRFMPPGPARNDGAPCLDPQPEPSQPSPPPIPALKNVLLNKVQRCLSSGDAPAASDAPVGSKALARVLGAAVPQGE--CKENHIRSMPDFPEPEESVNKDRRSPPLNTHASCTTTAHYYSVIWCKASSRKHKRWEGDAVLVARGRTVVLKDMEGRDIGRGSGYKASELESLCE-----GQTLMVGGKQIEVMGVISDQDYAKGRCFQDAAVEIPAESPTVSKTPAYRPVSKS------FTKPALKGGALTDSELDKPICKPRYDPNAPGALVMPRPTA---DHQWQYNKSGAPLVDVVIDPHLTNHLRPHQKEGVVFLYECLMGMR--------------------LAGRCGAILADEMGLGKTLQCVCVLWTLLRQGPYGGRP-----------VMKRALVVCPGSLVKNWAAEFNKWLGRERISVYTVDQDHR-------VEDFVSSP-LCSVLVISYEMLLRSVDRLKE--LDFGVLICDEGHRLKNSNIKTAGALTALSCTRRLILTGTPVQNDLQEFYSIIEFVNPGILGTSAAYRKIYEEPILRSRQPS--CTEEERCIGEERAAELFRLTGVFTLRRTQEIINQYLSERIEWTVFCKPTELQIRLYRVLLSTRPIRACLSGSHTYTHSPHLVCINALKKLCNHPALLYNTLQEK--ADEMYEGEVK-------ELFPEEYSTGAFSTADSGKLLVLTDLLSAIQHVNRTDRVVLVSNHTQTLDLLQDVCDQIGYKWCRLDGQTPVGQRQKIVDSFNSPHSSSFLLLLSSKAGGVGLNLIGASHLVLYDIDWNPANDIQAMARVWRDGQKKTVHIYRFLTTGSIEEKIYQRQVSKQGLSGTVVDLTKK-----AEHISFSAEELRDLFRFDPNTTCLTHDLLN-CKCSGDGNTPGSVKES--------------SEDTGRSCQLGRQADNAISVPQRVSMSELMHWRHFSGAVQS-----YGDIYLNQACNHITYAFQSTSKSKTTV-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38086-1", "uniprot_id": "RDH54_YEAST", "id": "P38086-1", "name": "DNA repair and recombination protein RDH54", "aln": "MAVISVKPRRREKILQEVKNSSVYQTVFDSG-----TTQMQIPKYENKPFKPPRRVGSNKYTQLKPTATAVTTAPISKAKVTVNLKRS-----------------------ISAGPTLNLAKKPNNLSSNENTRYFTIMYRKPTTKKHKTWSGDGYATLKASSDKLCFYNEAGKFLGSSMLPSDSDSLFETLFKAGSNEVQLDYELKENAEIRSAKEALSQNMGNPSPPTTSTTETVPSTKNDGGKYQMPLSQLFSLNTVKRFKSVTKQTNEHMTTVPKTSQNSKAKKYYPVFDVNKIDNPIVMNKNAAAEVDVIVDPLLGKFLRPHQREGVKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDISGCLLADDMGLGKTLMSITLIWTLIRQTPFASKVSCSQSGIPLTGLCKKILVVCPVTLIGNWKREFGKWLNLSRIGVLTLSSRNSPDMDKMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEKNKHLIDMLVCDEGHRLKNGASKILNTLKSLDIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFKRRFIIPITRARDTANRYNEELLEKGEERSKEMIEITKRFILRRTNAILEKYLPPKTDIILFCKPYSQQILAFKDILQGARLDFGQLT-----FSSSLGLITLLKKVCNSPGLVGSDPYYKSHIKDTQSQDSYS------------------RSLNSGKLKVLMTLLEGIRKG-TKEKVVVVSNYTQTLDIIENLMNMAGMSHCRLDGSIPAKQRDSIVTSFN-RNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIHRDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLKDLFSVHTDTKSNTHDLICSCDGLGEEIEYPETNQQQNTVELRKRSTTTWTSALDLQKKMNEAATNDDAKKSQYIRQCLVHYKHIDPARQDELFDEVITDSFTELKDSITFAFVKPGEICLREQ", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "D3ZXW3-1", "uniprot_id": "FSBP_RAT", "id": "D3ZXW3-1", "name": "Fibrinogen silencer-binding protein", "aln": "---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVGKARSSNFTLSEKLD---------------------------LLNLVKPYVK--------ILEEHTNKNSVIVEKNRCWDVIAVNYNAIGVDRPPR------------TAQGLRSLYKRLKEYAKQELLQQKEAQSDYKSSISEPTKKVVEMIPQISSFCLVRDRNHIQSTNLD---------------------------------------EAAQAGTSSLQVMVDHHPVAITVEVKQEEDIKPSP---------------------------------------ALVSSPQHNDALEQQEEHELMRVAEGSVSPSLSSVDMRMTSSPSSVPRR---DVFHQESGEHLRSLLRCDP--QVLQMLKEEHQLILENQKKFGLYVQEK----RDGLKR---------RQRLEEELLRAKIEVEKLRASRLR-----------------RDLPEYSSF----------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. * *:.. ** . : :* . :. : : : .. * : *: . :. : ::. ... :. : :: :* : : . * :. : : * : : . : .: : .:: .: . *: .. . * *: : ** ... *::: .: :: : : : . :* *** * ::*:: : :: : * : .:* : . ", "identical_positions": 24, "similar_positions": 88, "identity": "2.37%" }, { "cls_id": "homologset.agr.HGNC:17229", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A2Y4-1", "uniprot_id": "A0A8I6A2Y4_RAT", "id": "A0A8I6A2Y4-1", "name": "Cilia- and flagella-associated protein 45", "aln": "MPLSTGDASSSISTASNRSRNRTRYRTKAMNSEVDESLFGGVKPPPQDKCDSPIVVIRDKHAIRKTLSALGLDHKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTKEELNAREQAFKKEKEAILDAVTVRKKIMKQKEMAW--NNNKKLSDLEEVARARAQNLLQRANNLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIKKELDEEERRLDHMMEIDRQQSLQRQEDRERRRREERIRGKRHIVEQMKKNEEERSLQAEHREQEKEQMLAYLERLQEEDLQDLERRHQEKLKMQAEIKRINDENQRQKAEMLAQEKLADQMVMEFTKKKMAREAEFEAEQEKIRKEKEKEIARLRALQEKAQDYRAEQDALRAKRNQEVADREWRLKEKENAQKKIETEEKLRKSRLDQVAFKEHTLAVQVQRDRDEFERILRAQREQIEKEKREQEKKAAGCLQHANELRRQVRENQQKQVQNRLATFEEGRRLKEEAQKRRERIEDIKKQKLEELRATGLPEKYCIEAERKANILPPTSVN--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D9U9-1", "uniprot_id": "CFA45_MOUSE", "id": "Q9D9U9-1", "name": "Cilia- and flagella-associated protein 45", "aln": "MPLRPGDASSSASTASNRSRTRTRYRTKAMNSEVDESLFGGVKPSSQGKSDSPIVVIHDKHAIRKTLSALGLEHKTETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASQVLTKEELNAREQALKKEKEGILEAVTIRKKIMKQKEMTW--NNNKKLSDLEEVARERAQNLLQRADKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDEEERRLDHMMEIDRRESLQRQEDRERKRREERVRGKRHIVEQIKKNEEERSLQAEHREQEKEQMLAYLDRLQEEDLQDLERRHQEKLKMQAEIKRINDENQRQKAEMLAQERLADQMVMEFTKKKMAREAEYEAEQEKIRREKEKEIARLRALQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAQKKIETEEKLRKSRLEQVAFKEHTLAVQVQRDRDEFERILRAQREQIEREKQEQEKKAKGCLQHANELRRQVRENQQKHVQNRLATFEEGRRLKEEAEKRRERIEDIKKQKLEELRATGLPEKYCIEVERKANILPATSVN--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UL16-1", "uniprot_id": "CFA45_HUMAN", "id": "Q9UL16-1", "name": "Cilia- and flagella-associated protein 45", "aln": "MPLSTAGILSSSSAASNRSRNKARYRTKAVSSEVDESLFGDIKSPAQGQSDSPIVLLRDKHTLQKTLTALGLDRKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVW--NNNKKLSDLEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPATSVN--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NCB7-1", "uniprot_id": "A0A8M1NCB7_DANRE", "id": "A0A8M1NCB7-1", "name": "Cilia- and flagella-associated protein 45", "aln": "MPQSAASSSGKLSGGSAFTR---RYRTRALTSHVDESLFGSPKLHSTADMRNHPEGENERTRSLSHSAPSSKEPKSETIRIITKDLIRDLRIPSEDPSGQSVILSSNEFRRIMAESHVPSEEEKTARLEAQRQALEEAMDAAEQRKAQMRQADLSR--QKNQNLSELEAEARDRAQYLLERANTLRMEQEDEVKKLNELIQKVQCHAVRDVQIQERKLNSAEWLAEEKRLDAMMEVERRQALEAQEQIEQLRKQQRIQGKMCIIDQIQTRQEEKLLQDEMKEQEGQQLLENMERMQMEELKGIEKKKEEQKKLLQEIQKINEENLLAKEQKKEEERLADLRAVEYTRNKLEREAEYEAEQIRIKKDKEKEVARLRALQERDRDHKAEQDEIRARRNQEAAAREWRRKEKEQAKRKLEVEERLKAARLEQVTHKEHLLSIEAGRERAEFERVLRAQQELIEREYEKEEQRQQQIQKHADAVRQQVREREMQAVTQRREMFRERERLEEEARNRRARLDEIKEKKLKELKAAGLSPKYYKEVERKACVLP-------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VNU3-1", "uniprot_id": "Q9VNU3_DROME", "id": "Q9VNU3-1", "name": "Cilia- and flagella-associated protein 45", "aln": "MPCFSASNVRFVSAESQVQKKCNELRARAR------AQTAAYRPPACG-----------FHPTATSFGSFRRPLCDQSAAYDQKQLKRNERDRKRNQGTKQVVLRAGELRRLKDQGKLETVSEKLQRIEQHEEEHRKQLQMVEETRQRFKAIDEAKGVGASESRSTLLSEILEEKESVLSRAFLARQEQEQEVKQINRMILDAKCKAVREAQIHEKHLLSKALREDDERLARMVNERAQKALTEEDERERLEVEKRNRYAQEIRQQLSERENVRYLEAKRVADEAKDIRRATELLRSQEEQQRAFAQLRKQRLREELQRIRDMSNVFKTMFSEQERLADLRVTAYMRDKQEKERQLKEMKRLAKKEFERRQQRIFTVAAEAMETRQTNDELKYLKERDRVEREYRQREKEAAIARREAERDLLEARAQQAQEMKQRLALEIAHAGEEFAKVMDRMREEEEKQKVMDRQRDAQRQAYRQDLRQQMTDKQAERRRLAELEAGRVQKWLDHEKQRDVNIQQVINAKIAAMRDNCLPEKYLREVEKQLKNIQSSRNRIR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ... * * : . *::* : . : . . . :: ::: *: ..: . :.::: . *:.*: .:: : .* * : .: . :: . : :: : .:. * * . : :*.** * ***:*:*.:..:* ..:*:*:*:.** *:: . ::.** *:: :::: ::: *: . ::* : * :*:. .:: : * : :* ::: : :: :: : : .: :: *:::*.: . * :*:*** . : :.* :* : : : ::: *:. *: :: . : : :* :: :::: . **:* :*** * : *.* * :* :*. :: *::: : ** ::: :* *:: :.:: : : :*:*: :.: : . .: :. .:* .:::: . *: :: *. ** *.*:: : ", "identical_positions": 76, "similar_positions": 200, "identity": "13.69%" }, { "cls_id": "homologset.agr.HGNC:1723", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62623-1", "uniprot_id": "CDC20_RAT", "id": "Q62623-1", "name": "Cell division cycle protein 20 homolog", "aln": "-------MAQFVFESDLHSLLQLDAPIPNAPIARWQRKAKEATGPAP---SPMRAANRSHSAGRTPG---------------------------------------------RTPGKSNSKVQTTPSKP------------GGDRYIPQRSASQMEVASFLLSKENQPEDGGTPTKKEHQKAWARNLN------GFDVEEAKILRLSGKPQN---APEGYQNRLKVLYS-QKATPGSSRKACRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTS-HSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWVPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSP---------HYKELISGHGFAQNQLVIWKYPTMAKVAELKG-HTARVLSLTMSPDGATVASAAADETLRLWRCFE-----------------------------LDPALRREREKASTSKSSLIHQGIR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JJ66-1", "uniprot_id": "CDC20_MOUSE", "id": "Q9JJ66-1", "name": "Cell division cycle protein 20 homolog", "aln": "-------MAQFVFESDLHSLLQLDAPIPNAPVARWQRKAKEATGPAP---SPMRAANRSHSAGRTPG---------------------------------------------RTPGKSSSKVQTTPSKP------------GGDRFIPQRSASQMEVASFLLSKENQPEDRGTPTKKEHQKAWSLNLN------GFDVEEAKILRLSGKPQN---APEGYQNRLKVLYS-QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTS-HSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWAPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSP---------HYKELISGHGFAQNQLVIWKYPTMAKVAELKG-HTARVLGLTMSPDGATVASAAADETLRLWRCFE-----------------------------MDPALRREREKASVAKSSLIHQGIR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q12834-1", "uniprot_id": "CDC20_HUMAN", "id": "Q12834-1", "name": "Cell division cycle protein 20 homolog", "aln": "-------MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAP---SPMRAANRSHSAGRTPG---------------------------------------------RTPGKSSSKVQTTPSKP------------GGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLN------GFDVEEAKILRLSGKPQN---APEGYQNRLKVLYS-QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS-HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP---------HYKELISGHGFAQNQLVIWKYPTMAKVAELKG-HTSRVLSLTMSPDGATVASAAADETLRLWRCFE-----------------------------LDPARRREREKASAAKSSLIHQGIR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IU39-1", "uniprot_id": "A0A0R4IU39_DANRE", "id": "A0A0R4IU39-1", "name": "", "aln": "-------MSQFGFENDIHNVLRLDMPITNAPMARWQRKASTSNSSSTNSISPNKSVNRSVSLSKTPS---------------------------------------------KTPGK-NGKTQNTPSKA------------GGDRYIPTRNNKQLDVASFLISKENEPVEESEPSTAPNQKAWSMSLN------GYDIEEAKILHLGGKPLY---APEGYQNNLKVLYS-QVPTP-VSVKKSRYISSYPERILDAPDIRNDFYLNLMDWGRQNVLAVGLANQVYLWDAGEGDIVLLKKMEDDNEYICSVSWSKDGNFLAIGTSDCKVELWDVQYQKRLRSMDG-HSARVGCLSWNDHILSSGSRSGLIHQHDVRVADHHIFTFGGHTQEVCGLTWSPDGRYLASGGNDNMVYIWPMTTG-SENQAIHALSEHQGAVKALAWCPWQPNILASGGGTSDRHIRIWNASSGSCISSLDTCSQVSSLVFAP---------NYKELVSGHGFAHDKVVIWKYPSFAKVTEHEG-HEARILNLALSPDGSTLASIAADETIRLWKCFE-----------------------------KEKDAAKKPKQASG---RIVQQSIR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P26309-1", "uniprot_id": "CDC20_YEAST", "id": "P26309-1", "name": "APC/C activator protein CDC20", "aln": "MPESSRDKGNAAISGNRSVLSIASPTKLNILSSDWSRNQGKVSKNSLKRSSSLNIRNSKRPSLQASANSIYSRPKITIGAPPLIRRDSSFFKDEFDAKKDKATFSAYSSRSYPTIGSESVVSQTSLSQPTTSREVDEQFTVAADRYIPILQGASQNKVDPETLHEALPPPNASPISHLRAQTKIVFKQNVAEACGLDMNKRILQYMPEPPKCSSLRQKSYIMKKRTHYSYQQEQKIPDLIKLRKINTNPERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDFEN--TTICSVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMRSGLGVRIGSLSWLDTLIATGSRSGEIQINDVRIKQHIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTS----LPQFSKKTHTAAVKALSWCPYSPNILASGGGQTDKHIHFWNSITGARVGSINTGSQVSSLHWGQSHTSTNGGMMNKEIVATGGNPENAISVYNYETKFKVAEVVHAHEARICCSQLSPDGTTLATVGGDENLKFYKIFDPRCTGRSREDGLMDGMLGLIGKEGCRTNDKENRSKNSSEIHTRRPSSTSQYLIR", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: :..: : . . * : *.*: : *. . * . . ::.. * *. . *.: *:. ..**:** . . : .. :* * * . . :: : * *::: : : * :.* . :. ** * . * * : *:****** :::*:****:.*. ****:.* . :***.* **: * .:*: *.**:* .:. .:::*... :.::***: . :*.* . ..*:..*** . ::::***** *: :***: :* : * . *: ***** : .** ******** * :* .. . : . * .****::***:..*:**:*** :*:**::** :*: :.:::. ***.*: :. **::: * ..: : :::* : **:* * :*: :****:*:*: ..**.::::: *: : .. : : : **", "identical_positions": 138, "similar_positions": 173, "identity": "22.4%" }, { "cls_id": "homologset.agr.HGNC:17230", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B1AQ85-1", "uniprot_id": "B1AQ85_MOUSE", "id": "B1AQ85-1", "name": "", "aln": "MVSS-CGSVCSEEGCGQG-----CCQPSCCQTTCCRTTCCRPSCCVSSCCRPSCCVSSCCRPSCCR----------PQCCQSVCCQPTCCRPSCCISSCCQPSCGSSSCCGSSCCR-PCCRP-CCSPCC--SPCCRPCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCAIPCC---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYQ9-1", "uniprot_id": "KRA48_HUMAN", "id": "Q9BYQ9-1", "name": "Keratin-associated protein 4-8", "aln": "MVNSCCGSVCSDQGCGQDLCQETCCCPSCCQTTCCRTTCYRPSYSVSCCCRPQCCQSVCCQPTCCRPSCCVSSCCKPQCCQSVCCQPTCCHPSCCISSCCRPSCCVSSCCKPQCCQSVCCQPNCCRPSCSISSCCRPSC--CESSCCRPCCCLRPVCGRVSCHTTCYRPACVISTCPRPVCCASSCC---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D4A8A6-1", "uniprot_id": "D4A8A6_RAT", "id": "D4A8A6-1", "name": "", "aln": "MVNSCCGSVCSEQGCDQSPCQESCCQPSCCQTTCCRTTCCRPSCCVSSCCRPS-CQTTCCRPVCCQTTCR-PSCGVSSCCRPVCCQ-TTCRPSCGVSSCCRPVCCQTTCCQSSCCRPVCCQT-TCRPSCGVSSCCRPVC---CQTTCRPSCGVSSCCRPVCCQTTC-RPSCGVSSCCRPVCCQTTCCRTTSCGPSC", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.* ******::**.*. ** ************* *** .**.****. * : **:* **: ..**:.**** * *:*** :****:* * ::** ..**: **:. * *.* *.**** * . ***.* : . * *.*:*** **:* :*:* **:** .** ", "identical_positions": 95, "similar_positions": 38, "identity": "48.47%" }, { "cls_id": "homologset.agr.HGNC:17231", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2A4M2-1", "uniprot_id": "A2A4M2_MOUSE", "id": "A2A4M2-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCC-QPCCQPSCCQSSCCQPSCCQPSCCQSSCCQPSCCQSSCCQPRCCISSCCQPRCCISSCCQPCCRPSCCQSSCCKPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZAY4-1", "uniprot_id": "D3ZAY4_RAT", "id": "D3ZAY4-1", "name": "", "aln": "MTNSCCSSCCQPTCCRTTCCRTTCWKPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPSCVSSCCSTPCCQPCCCVSSCC-QPCCRPSCCQSSCCQPCCCE-------------------------SSCCQPRCCISSCCQPCCKPSCCQSSCCKPCCKPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q64526-1", "uniprot_id": "Q64526_MOUSE", "id": "Q64526-1", "name": "", "aln": "MTNSCCSPCCQPTCCRTTCCRTTCWRPSCVTSCC-QPCCQPSCCGSSCCQPCCQTTCCR-TCFQPCCVSSCCRTPCCQPCCCVSSCC-QPCCQPSCCQSSCCQPRCCE-------------------------SSCCQPRCCISSCCQPCCRPSCCQSSCCRPCCQPFCLNLCCQPACSGPVTCTRTCYQPTCVCVPGCLSQGCGSSCCEPCGC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BYQ0-1", "uniprot_id": "KRA98_HUMAN", "id": "Q9BYQ0-1", "name": "Keratin-associated protein 9-8", "aln": "MT-HCCSPCCQPTCCR-----TTCWKPTTVTTCSSTPCCQPSCCVSSCCQPCCRPTCCQNTCCQPICVTSCCQPSCCSTPCCQPTCCGQTSCGSSCGQSSSCAPVYCR-------------------------RTCYHP----TTVCLPGCLNQSCGSNCCQPCCRP----ACCETTC-----CRTTCFQPTCV-----------SSCCQPSCC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ***.******** ****:*: **:*. ******** ********:.***: ** ** **:*** ..**.. ** .:** *..* .** ***.* * *. :* :* :: * * * ..* *.**:***:* **:.:* * **:***.* ****:*. *", "identical_positions": 94, "similar_positions": 36, "identity": "43.93%" }, { "cls_id": "homologset.agr.HGNC:17233", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96JJ3-1", "uniprot_id": "ELMO2_HUMAN", "id": "Q96JJ3-1", "name": "Engulfment and cell motility protein 2", "aln": "--------------MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGP-QLYITEQTRSDIKNGTILQLAISPSRAARQLMERTQSSNMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSITFIKQIAGYVS-QPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQD------------MANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAES------DPSNAPGSGTEKRK-AMYTKDYKMLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPP--IVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRRRQERFWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEVLELAFSILYD--PDETLNFIAPNKYEYCIWIDGLSAL--LGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIPEAPPPIPKEPSSYDFVYHYG------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8BHL5-1", "uniprot_id": "ELMO2_MOUSE", "id": "Q8BHL5-1", "name": "Engulfment and cell motility protein 2", "aln": "--------------MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLPNPEYYTLRYADGP-QLYVTEQTRNDIKNGTILQLAVSPSRAARQLMERTQSSSMETRLDAMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDMVSVTFIKQIAGYVS-QPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQDKHLNPLDLPVTDMANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAES------DPSNVPGSGTEKRK-AMYTKDYKMLGFTNHINPALDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPP--IVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRRRQERFWHCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEVLELAFSILYD--PDETLNFIAPNKYEYCIWIDGLSAL--LGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIPEAPPPVPKEPSSYDFVYHYG------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6G6K9-1", "uniprot_id": "A0A8I6G6K9_RAT", "id": "A0A8I6G6K9-1", "name": "", "aln": "MVQQLSPEVGPLGTMPPPSDIVKVAIEWPGANAQLLEIDQKRPLASVIKEVCDGWSLPNPEYYTLRYADGP-QLYVTEQTRSDIKNGTILQLAISPSRAARQLMERTQSSSMETRLDAMKELAKLSADVTFATEFINMDGIVVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDHGIVSWDLVSITFIKQIAGYVS-QPMADVSVLQRSLAILESMVLNSQSLYQKIAEEITVGQLISHLQ-VSNQEIQTYAIALINALFLKAPEDKRQD------------MANAFAQKHLRSIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAES------DPSNAPGSGTEKRK-AMYTKDYKMLGFTNHINPALDFTQTPPGMLALDNMLYLAKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEILRLRQSERMSQDDFQSPP--IVELREKIQPEILELIKQQRLNRLCEGSSFRK-IGNRRRQERFWHCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSALKQNKEVLELAFSILYD--PDETLNFIAPNKYEYCIWIDGLSAL--LGKDMSSELTKSDLDTLLSMEMKLRLLDLENIQIPEAPPPVPKEPSSYDFVYHYG------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0AC58GP09-1", "uniprot_id": "A0AC58GP09_DANRE", "id": "A0AC58GP09-1", "name": "", "aln": "--------------MPPPSDIVKVAIEWPGANAQLIEIDQKKPLASIIREVCEGWSLSGSEQFALRYADGP-QLYITEQTRGEIKNGTILRLAISPMRAARQLLERIQSHSIDARLEALKELAKLSADAAFASEFINIDGLVTLARLVESG----THFGEMLAFTLTAFLELMDHGIVSWELLSLSFIKQIAGYVN-QPMVDVSILQRSLAILESMVLNSHSLYQRVAQETTVAQLITHLQ-VSNQEIQTYAIALINALFLKTPEDRRQE------------MAATLAQRHLRAIILNHIIRGNRPVKAEMAHQLYVLQVLTFNLLEERMMTKMDPNDQTQRDVIFELRRIAFDGDA------AEP----SGTEKRKAAAHTKDYRMLGFSNAVNPALDFTQTPPGMLALDNMLYLAKLHQDTYIRIVLENSSREDKHECPFARCAIELTRVLCDILQVGELPNEGCNDFHPMFFTHERAWEEFFCVCIQLLNKTWKEMRATAEDFNKVMTVVREQITRALALKPASLDQLRLKLRSLSYSEILRLRQSERMSQDDFQSPP--IIELRERIQPEILELIKQQRLSRLCEGSCFRK-LGNRRRQEKFWFCRLSLNHKLLHYGDLEESPQGEVPLELLTDKIAVSDIKAVLTGKDCPHMKEKSALKQNKEVLELAFSILYD--PDESLNFVAPNKYEYCIWTDGLSAL--LGKDLSSDLTRSDLDTLMSMEMKLRLLDLENITIPEAPPPVPKEPSSYNFSYNYG------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VKB2-1", "uniprot_id": "Q9VKB2_DROME", "id": "Q9VKB2-1", "name": "", "aln": "--------MIPKKTTVKDSHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIEDGG---QTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLENIVMCSN-KHVLVAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRT------------IAQTISAKQFRLALIGNGLG------TEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGN-VNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDKFWYARLSPNHKVIHYGDCDEKTIP--TMEELPKKLPISEIKQLLEGKECPHMKET---RIRKSAVNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINAL--LGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGVDISKDPPPIPEDPENYDFCFES-------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07799-1", "uniprot_id": "LMO1_YEAST", "id": "Q07799-1", "name": "ELMO family protein LMO1", "aln": "-----------------MKHNRQMPDESLENIKVLLNPKLGKPVKSLTSAQSKACYHTLISNKNLNKTSDEYEKLLAN-YILLCDEKYLCKTVIPDSRFWAILCDNCQKLRSETLVANLIRIFNVALKCQDSNKNEVIVSICHISRENSQLIGILLQLLSQRPIHIPLFTDTILCITLFLKCSLTLCETSLSHAVEFVPRILILLFQYNFPASMSELLYIEDLQPLILEEFVP-LKQRLINFLSSVSIDDYSCSLKADLLTAIKD-------------------NSVFQKGLEMEMG----------DLPSINLLNAYDTFTFLNSPNGSFKRLYTEQLLFGENDFPLYEAIFKLSD----------------------QFRRLFNLSGKKENQYSDSERDLKLQIATAVLNRQTCFYKTLELFLRFWIESLAKSQSDLVSLLNLAIITLKYVCLSSSDLEAAIQTKSLLKTQVVALD-SMRYKFARTLQLDSIKKEQYRTWSSSIASFDTMLSGQVR-----------------DYVRHQRLLQLQKGTWVYAENPLNPE-----------------AGTPKVYFLIVSDNHAN-LLAREFETQTNDLPYLFDNKILTSPGSEALANGRTKVVVLKHITSFKSIELTTPSR---RTSSNVYIKLDEANVYTGVELKDRN-DRTVLKFYLDTEEGRYIWLDGLKLISPFQHEDISEDTKEQIDTLFDLRKNVQMINLNVRQDIIVPPPEPSDEDEDEEFYNLETLKKVTQNFYFD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. ::. * *:: . :*: * ... . . *. . . ::: .: : : . : : . : : .: .:: . : : .: : : .. . :. * : : : . * : :. . :: . : :: :: :.. : : :* *: : :. : :. : : * . :.:*: : :: .:: : * . *. . . : :. * . . : . *: : : :: *. .: :.. .: . :* : :* * . : . :. ..: : . . * : . . :: *: :..: . :: *: : :..: *:: :: .. :: * . . : : . : : ::*:: . : . . * . .. .*: .: : ... : : : ...: *.* : * **:. : : : *. ...::***:.:. :::::: : *** *.: .. : :. ", "identical_positions": 40, "similar_positions": 221, "identity": "5.16%" }, { "cls_id": "homologset.agr.HGNC:17234", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A697-1", "uniprot_id": "A0A8I6A697_RAT", "id": "A0A8I6A697-1", "name": "", "aln": "MKKILVHGVKEKTPMGFCDVPRKNLLDFLRDMKSISVPNEPRYKPLRKIHQAASEGDTERLQKMISLGKHS-VHDRDFKQRTALHFACAYGHVEVVSVLLRNNCDIDAADRNSITPLMKAVQNWTYECVCTLLKHGADPNRMDKNGNTSLHYAVSEDNQTLAKCLLKYSANLEQKNKDGFTPLLLALKENKIEMAKFLVKKGANIHVFDEMKRNTLLYAIRWDSKDMVNLLLDEGIDFFFKDVFGWTALRYAIEGTSKGSREILMNYDEKLRRKNKNGIPEYKKFEDNSLDKHPNDPTSGSNLPKSSENACDFDYELDISKCALTTCPSNICGAGDQEDKSEAKATVDVQVLKNPALKSSTKGKVSILNEVRTMTESHHFIIESDLEIESLEETFSYDNEDKQSVSDDGHFSGTPEWDQNDTNRQTTDSAKKYPNLKTVNERNHLIQNKRSENKDEETLNSELTIASTSEEEQECPDSRGKKQRMQTGPTDIVYLVTVKNQREENMGMSQEKATPEEHPEPQCSTEKTYSIANEESDTNQEDSLHAEQVVELTTEKEQKKAYNNSKQCLNIFKRLRPKRIGSLFMTRDKSEENAIAAEEKEFPKEYGQLKSTTEEGDSMPNDSRTKTSAKSLQTESAVMFTTEKGEKCQLDSDKNNQGHMLKQSQPKMTSHLSVTEGQYDESTINDQVKVSINCVDSPQKPDVKSRLEEEHKSHGNGEKSQHEHMFKMPRPKGAARVYFDPLEQYSQCKATNERKDHDLDSNSSMMGVKTSCAEANVKLKTEENLDGEKTSQSSLSLGLTSTPTNMLNGGGKGFQKKFLEWKPPTEMKDSDSTEVSDMTPGQEFPADVDIKLETESQDYLDSSENTQSSNTITSLQSKCIPQFSVGITSGSTSLLTEGEQAFHKKNPDQKSTQQLTGSKVLASSEVSVLKHKQEFPPEVYLQMKTEESQKNLDRNENIPSSNAVIQPKQILHLPIRPALRPMNLLNEGKKAFRDKYPEQESSIEENYVSTDKSAVKCGQEFPAEADWEIKIEDFQENLDDNGSIQSYDSFTCLQPRPSPYLSLGLTQRPQIFLDEEGKGSHKKHPEWKKNPSTHRENSLPPESSEWRHEQEHPSEVDIQMKAHGSHKNRDGRESSRSTYNMSDLHLFHAPPSSAATDLLHEGGKEVELKDEPVKNQNNLESNTNIQPSDSVMHLPPRHILHSSVGISPTFSNPPNAGEAEDLQMKLEENQRKFDGNESIQLSDNMKHLQPRRIRHLLMGLIPRPMNILNRRGKGSHKKCTPCKDPIEIKEFDPNAKLERQEIKTFTSVMIEDDQNLRDGSKHKQPLVEATRKKDKSNGTEDATQSSGSSLATTAHAISTASVVAAIVAATVVAEAAPAAAVAAASAAVAAVVAATAPAAAAVASATVAVDALADVAPEAALDSSAVPVAAATAAVAAAVPAAAVASAPDGAPAVVSAAAAAAAAAVAVTSVAAASLTAVSAASVAAVVAVAVTAAAGSDAPTVAPATAAVAAVAAATGPAAAAALVASVAATAVTPCVPPAAPSSAAAPSTVAAATAAASAVVTYAAASPAVAAAAAAAVAIAVSVPTGATAAVAAVASSDTPTAVPAAAAAAAATIKRRPSPQRKYVKERRQQSPVEEAEEQDGFKMTISTKNVKPVKDIHDLNTVIPVTELCSAEYLDSPLKSIPALDSYKELLELKEIN-----IQILTEKTKVENELSEVKEENSQLEKKILRKNERICTLRSIIKEQMEKKRNVIFAYNEVVEELRDKEEMIQKSGEQYNRQVSETQELEICLKTRDVELKQLKKEKEHAQKMEDHLQILELENTSLIATVKKQKEEIEQLQRCVQNPLKNLAQSTNSTETAAQENQNMWNDHTTVITEMENIIKSLKSEVSSVKISKEFSKRELEKYKRFYLAELRNKNFLLHELNRTNESREQSHTELHMKFQQNISASNTLNTRLVHECSCVEKTHELENKDFLPGENLVLPSSSTESNQVCMAHYPWTSEDDVRDLSEGLSDLKQSIQLSLETQQKQDHEVDKELVGIGKSFKMTDRRHEIGECGSHGDFETCQLGISTPATMPGCLAQATSKPYSEFLKESYTTSTINAMETKIRSLKSTLSKLKVSRALRVLELERYKYLYYEELNIRKSFTVYTLLRNNENSEKNKSKLHTETQQSSSAVNAKSMRPLTECSSAGCFDSIPGPKKSYSERKPDGIFLKLSTINKWLGRLPENDATSVPVELWRSK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXX3-1", "uniprot_id": "AN30A_HUMAN", "id": "Q9BXX3-1", "name": "Ankyrin repeat domain-containing protein 30A", "aln": "MEEISAAAVKVVPGP-------ERPSPFSQLVYTSNDSYIVHSGDLRKIHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKN------------------HQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDEAAPLVER-TPDTAESLVEKTPDEAASLVEGTSDKIQCLEKAT-----------------------------------SGKFEQSAEETPREITSPAKETSEKFTWPAKGRPR-KIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKETPVKTGCVARVTSNKTKVLEKGRSKMIACPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFESSAKIQVCIPESIYQKVMEINR------------------------EVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQTLRADPMFPPESKQKD---------------------------YEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKD-----------------------------------------GLLKATCGMKVSIPTKALELKDMQTFKAEPPGKP-------------------------SAFEPATEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLP-----------------------KAAHQKEIDKING------------------------------------KLEGSPVKDGLLKAN----CGMKVSIPTKALELMDMQTFKAEPPEKPSAFEP--------------------------------------------------------------------------------------AIEMQKSVPNKALELKNEQTLR-----------------------------------------ADEILPSESKQKDYEESSWDSESLCETVSQKD---------------------VCLPKATHQKEIDKINGKLEE----------------------------------------------SPDNDGFLKAPCRMKVSIPTKALELMDMQTFK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEPPEKPSAFEPAIEMQKSVPN----------------------KALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELG-------RIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQ------------------EKENKYFEDIKILKEKN------AELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLKEKQD-KEILEAEIESHHPR-LASAVQDHDQIVTSRKSQEPAFHIAGDACLQRKMNVDVSSTIYNN--------------------------EVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQRDQR---------------ETQCQMKEAEHMYQNEQDN------VNKHTEQQESLDQKLFQLQS-----------------------KNMWLQQQLVHAHKKADNKSKITIDIHFLERKMQHHLLK-----------------------EKNEEIFNYNNHLKNRIYQYEKEKAETENS------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*::* . .** . :. * : : : . . : *****:***.*:..:*:** . * :: :* ::*****:**. ** ***:.*: .:*::*. * : ******:* *. *:. *** * :* ***:***** .: ::. **.:.* :* :** .:*****::.:.. ::.:**: *.** :..:: * .:*: *: .*.::*.:**::.:*.* *: * ** :**: : :* :*:* .** :: * * ..*:. ...* * : * ::. : . *.: . :: . *:: *: : .:* ..*..*:. *::. .*:*. :.* .: . :.::::*:. . . * :: :*:.:. * :: * . : : * . . ::: . *. * ** :: : : * *: * * :....:.*::. ::.:.: ::* * .:..:.* ::: : . . :: ::* : * :* **: . :*.: * :*:**.: .. ::*:::. . ::: : *..:*..:: : *. . *: .. : . .::: : :. * : . .: *:*.* . ::** :.:..* ..:. ::*.***:.* ..:. ::. * : ** : *::.:** :.* :*:* .* :. *:* * ..**. :::.* : *. * .:.:::.: :: :: . * . ::*: : **: *::* : . ::*:* :: * ::** * ::* . .*: : ::.. ..:. *: :: : :.:..: * :.:: **** * .: * * .:* *. ** :::**. * .* .:* .*: : ***. * . :: .:: : .* :*:. *:: :.:.:: *:* *:* * *: : :* .: *.. *.:: : : :** : : : *: .: ::::***.** :****:: :: ::.:*::* :::: **:**. : ::: *** : **:.:::. .*:** .*: :*:***.::.: ::..: .:: : * ** * : * ** *:: * *::* : :. .::.* : . ::*:.:* .:. .:*. . : ::.:* :*:..:: :* .:*:. :. : :::: : ::* . .. * :..: .. * : * **: .* : :: .*. *::.:.:. :* *.::: . * .: ..: . * : :.: *.: .: :* : .**...* :*: *.: : * : .:. .****: : : . :: : :: .* : ** . ::: : : ::.* : ", "identical_positions": 300, "similar_positions": 606, "identity": "13.35%" }, { "cls_id": "homologset.agr.HGNC:1724", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6AB31-1", "uniprot_id": "A0A8I6AB31_RAT", "id": "A0A8I6AB31-1", "name": "Cell division cycle protein 23 homolog", "aln": "MAANSSVVSVAAAATTVPGVSTVADFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALP--LSELQPPP-------PLTEEDAQDVDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDD-------------------------------------ETVDSLGPLEKGQVKNEALRELRVELSRKHQARGLDG-------FGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLS--------------------LPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQD-PYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQC--YIKYIQDIYSCGETVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRN----------------------------------------------------------------------QGETPTSDTPGTFFLPAS------------LSANNTPTRRVSPLNLSSVTP---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BGZ4-1", "uniprot_id": "CDC23_MOUSE", "id": "Q8BGZ4-1", "name": "Cell division cycle protein 23 homolog", "aln": "MAANSSVVSVAAAATAVPGVSTVADFSDLQEIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALP--LSELQPPP-------PLTEEDAQDVDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDD-------------------------------------ETVDSLGPLEKGQVKNEALRELRVELSRKHQARGLDG-------FGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLS--------------------LPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQD-PYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKKALVKLAKLHEQLTESEQAAQC--YIKYIQDIYSCGETVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRN----------------------------------------------------------------------QGETPTSDTPGTFFLPAS------------LSANNTPTRRVSPLNLSSVTP---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJX2-1", "uniprot_id": "CDC23_HUMAN", "id": "Q9UJX2-1", "name": "Cell division cycle protein 23 homolog", "aln": "MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALP--LAELQPPP-------PITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDD-------------------------------------ETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDG-------FGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLS--------------------LPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQD-PYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQC--YIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRN----------------------------------------------------------------------QGETPTTEVPAPFFLPAS------------LSANNTPTRRVSPLNLSSVTP---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9I7L8-1", "uniprot_id": "Q9I7L8_DROME", "id": "Q9I7L8-1", "name": "Cyclosome subunit 8", "aln": "------MAMQKFFSVLLPDVK--------RELRRGIIECS----KRGLLHSTKWLAEMHHGLADVH--IDNEAPDEDRTFSECQLEGIAPEEYSDYFLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLD-------------------------------------STTDQANLHEPNQMR--DLADLLATLRMEYGKSRLDG-------YGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLIMEKKKLLSLQ--------------------LGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKRDVDKAIELYQALLESD-PYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLGQAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYKLANLHEKLGDHETAVHC--YIMYCEDERAA---TDKQSLYQGFITLANYYEKKGEYERAAYYAYKCLDSEDRKMEAKALLKTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRVRVPITSIATTTTSTTTVAAESASSSSLISLRPDRNLIQGMRRSQSSRTSLTAPASGTTTTPSATAVTMSTEETPGTSGGPSNPPEQAPSDDNSSMEISSVSID", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "E1JHM5-1", "uniprot_id": "E1JHM5_DROME", "id": "E1JHM5-1", "name": "Cdc23 domain-containing protein", "aln": "------MAMQKFFSVLLPDVK--------RELRRGIIECS----KRGLLHSTKWLAEMHHGLADVH--IDNEAPDEDRTFSECQLEGIAPEEYSDYFLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLD-------------------------------------STTDQANLHEPNQMR--DLADLLATLRMEYGKSRLDG-------YGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLIMEKKKLLSLQ--------------------LGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKRDVDKAIELYQALLESASPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIRCDHQVAISYFQRALKLNPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P16522-1", "uniprot_id": "CDC23_YEAST", "id": "P16522-1", "name": "Anaphase-promoting complex subunit CDC23", "aln": "-------MNDDSQDKIIHDIRIQLRKAATELSRWKLYGSSKWAAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKQMFEIPQNGFGLSETEYDLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGKFTDEMYRANKDGDGSGNEDINQSGHQRANLKMVSNEHESQSNISSILKEINTFLESYEIKIDDDEADLGLALLYYLRGVILKQEKNISKAMSSFLKSLSCYSFNWSCWLELMDCLQKVDDALLLNNYLYQNFQFKFSENLGSQRTIEFNIMIKFFKLKVFEELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQD-PYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEELLEGIVTDETVKARLWLAIFEIKAGNYQLAYDYAMGVSSGTSQEIEEARMLARECRRHM----------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : : : : : .: ..*. : : . * *..: :*.:*:**... ::. . ** :** ::: :*: : . . . . .* . : . : .: *. ** **:*: . . * . :::: .: *..:*** : . . *. : * .** : : ** : .: *.: :: : * :* * .* . :: : :. ***:::::*:**:*:* . ::::: **: .*:::* ****:*.**** * :*: : **:***.*: : ", "identical_positions": 64, "similar_positions": 114, "identity": "8.31%" }, { "cls_id": "homologset.agr.HGNC:17241", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O95361-1", "uniprot_id": "TRI16_HUMAN", "id": "O95361-1", "name": "Tripartite motif-containing protein 16", "aln": "-------------MAELDLMAPGPLPRATAQPPAPLSPDSGSP--------------SPDSGSASPVE-----EEDVGSSE--------------KLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQV----------------------NIKLQSHLLTEPVKDHNWRYCPAHHS----PLSAFCCPDQQCICQDCCQ-EHSGHTIVSLDAAR------RDKEAELQCTQLDLER----------------------KLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQ-AALSQANGIKAHLEYRSAEMEKSKQELERMAA-ISNTVQFLEEYCKFKN-TEDITFPSVYVG-----LKDKLSGIRKVITESTVHLIQLLEN------------------------------------------------------------------------YKKKLQEFSKE---EEYDIRT--------------------------------QVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQS-----------------------------LYLHR-----------------YYFEVEIFGAGTYVGLTCKGIDRKGEERNSCIS--------------------------------------------GNNFSWSLQWNGKE----------FTAWYSDMETPLKAGP------FRRLGVYIDFPGGILSFYG-------------------VEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP--------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q99PP9-1", "uniprot_id": "TRI16_MOUSE", "id": "Q99PP9-1", "name": "Tripartite motif-containing protein 16", "aln": "-------------MAELDLIAPGPLTGVTAHPLAPLGPDP---------------------VSAIPVE-----KEDADPLS--------------KSGEETQEQGHDPAELGAP-GEEDQILCDFCLGASR-VRAVKSCLTCMVNYCEEHLRPHQE----------------------NSKLHSHQLTEPAKDQDLRTCPAHHS----PLVSFCHTHQQCICQECGEGEHRGDSTVSLDAAR------RNKEVDLRCMQLDLEQ----------------------KLKLNENAIARLQANHKSVLVSVSEVKVVAEEKFGELLAAVRKAQADVMVFLEEKEQ-AALNQVNSIKTHLEHRSLEMEKSKQELERLAA-ISNTVLFLEEYCKLKK-TEDTASPSIYIG-----LKDKLSGIRKVITDSTLNLIQLLES------------------------------------------------------------------------YKEKLQEFSRE---EEYDIRT--------------------------------QVSAIVQRKYRTSKPEPRTRDEFLQYACDITFDPDTAHRYLRLQEDNRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQS-----------------------------LYLHR-----------------YYFEVELSGGGTYVGLTCKGIDRKGEERNSCIS--------------------------------------------GNSFSWSIHWNGKE----------FTAWHSDTETPLKVSP------FRRLGIYVNFPGGILSFYG-------------------VEYDAMTLIHKFDCKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAGSSVEAAP--------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M1P9M9-1", "uniprot_id": "A0A8M1P9M9_DANRE", "id": "A0A8M1P9M9-1", "name": "", "aln": "-------------MSAMVLTAELPACSMTSEIPKEEKIEENRPKYTEV-------EDKKIQVNGSPPEKHTEGEKDVKTIEESKIQKDLKEIEVNKESKDPQKDDEDDEEEEEEVLGPDVVTCDSCIDKPC--RAKKSCLTCLVSYCESHLRPHLE----------------------NAKFQSHRLVDPLRDIERRTCEAHRS----PLELYCC--MCCLCPACVTEEHLGHQALPIAEAR------RNIEKELQDKQTEMLK----------------------TMTAAENAINKLQVNTVSIEGSVQEVRAVMEEQFSILQAAVEQVKRDVCELLEAEER-QALRQADGIRVHLEQRCAELKKTQSRVQKISK-NKHDIHFLQEYSEWKKEAVDVSLPGVYIG-----LVDRLQAFSHVIVRSTNRMCDNLHSS-----------------------------------------------------------------------YTNKLKDTCKN---DNVGIKT--------------------------------TVFAVMAAKKNMMLPDPKTRDDFLQYVTPLSLDANTAHVFLRLTEECKKVTNTTPWQHSYPDLPERFQDFKQVLTQES-----------------------------FYLGR-----------------HYFEVDMKGEGTHVGLTYKSIDRKGSQSNSCIA--------------------------------------------GNNFSWCLQWNGRS----------FSAWHSDVETPLSCPK------TTHIGIYVDYSGGLLAFYD-------------------VENG-MTLIHKYQAEFLEPLYPAFWLPKKENVVLLEPGAASPLSSPSPSPDASTK-------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "D4A8I5-1", "uniprot_id": "D4A8I5_RAT", "id": "D4A8I5-1", "name": "", "aln": "MENTEQKLRQSPYFCCEKGSNWVPVCHKCEACVLAWKIFATKEWFRRVNDTSQRRFLVSILVQLNSLYLLQYFQNILETTQGKDFIYNRSRIKLNRKGGKEEEVVKSSLNQMLDKTVESKMKEILCWFGNSTHRTKANYTLLLLQMCDSNLLLTAANVIRVLFMKEWNNISGLREDASNVIFFPEKTYNATHDISYISWSARPKPVSFPMSRHLGNKLGTENVDKGTTEAKAKSSLHVISEINKEIFGRGGTSRLGDEPCNLLLSLDHVQLLSSGFSKYRDFIRDLPLHLSKYILRMLDKNSLNKCVFVSQHWATLVQQVKVDQSMHSFIQNQITLLQGSYTRGIDPNYANKVSIPVPKIVDDGKRSRSKNQKWKLRTKNDYNLWTAYQNQETQLIQMEERNVFCGTYNIRILSDTFDQNRIIHYSGGDLMAVSSNRKIHLLDIMQVRELPIEFRGHAGSIRALFLSEEDNILLSGSYDLSIRYWDIKTGACIRIFYGHQGTITCLDLYKNRLVSGAKDGQVKEWDIETGKCLKTFKHKDPILAARISETYIVSSCERGIVKVWHVVTAQLQKTLTGHEGAVKCLFFNQWHLVSGGADGLVMAWSMVGKYERCLMAFKHPKEVLQVSLLYLRVISACGDGKIRIYNFLNGNCLKVIKVDARGDPVLSFFYQGNRWVVGRMVVHTDSSILVFQFENVKWQYSSDKNKTKKNKDKEEEREETSLGDTHSKSSLQVHSLRDSGSIKQEFSKSRVLLKQTRNLSSDDVENPGSEASYPLQKSGKVPITPDRFLLTLNALQAHNSEEFAYPHRPRIQVIDAWGLSIPYQRKVLTFKGKSVQHAVDQLRSSNLLTDVKQTNIPLEIRKLQPDLKKSLHSPRVQASIPQPSLIRPKVSDSLRGDEHLTSSIDGRAGPLTSLQVIKPNRMLAPRGGTTTLSLKKERPRFYTTLNPLRMNTGFMLLTVKEEKEFAEAKIKEYEASVSTKEVDPGKASKAAWIRKIKGLPIDHFLKEGKTAAPELGQNVFI", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. * . . :: . . : . . :: . : . : * :: . ::. *:.:* * : .. :. :* . *: . *: . * .. : : *. * :: : : : *: * . *.: .. :. : : :: : : .: : : : ::::.. :: .: : * : :. : .:: * : . ::* * : . *.::* . .:: .: .*.* * :: : . . * : .. .: : : .::*. * : : : : . :* . . ** .: . * *. *:: .. ::.:. *.. *: :: .*: :.* :. . : *: : : :*:* . : . ::* .: :.::.. .. : : .. : ", "identical_positions": 40, "similar_positions": 176, "identity": "3.92%" }, { "cls_id": "homologset.agr.HGNC:17245", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5U901-1", "uniprot_id": "CBPA6_MOUSE", "id": "Q5U901-1", "name": "Carboxypeptidase A6", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------MNFLGNPRSHTAAFLPVCWLLLNILKP------------------GHCHSYDNRYAGDKVIRLIPKSEEEALALKNIYHQLKVDLWQPSSISYVSEGTITDVHISQNASRTLLAFLQETHIYYKVLIEDLQKAVENENSLQTQ-----RNRRSLSEYN---------YEVYHSLEDIQSWLHHLNQTQPGLVRVFSIGRSYEGRPLFIMQLGRKSRA----YKRAVWIDCGIHAREWIGPAFCQWFVREAILTYKTD-----------PAMKKMLNHLYFYIMPVFNVDGYHFSWT--HDRFWRKTRSRDSKFR--CRGVDANRNWKVKW-CDEGASAHPCDDTYCGPFPESEPEVKAVANFLRKHRK--RIRAYLSFHAYAQMLLYPYSYKYATIP-NFSCVEFAAHKAVKALRSVHGIRYRHG-PASQTLY-----VSSGNSMDWAYKNG-IPYAFAFELRDTGHFG----FLLPEMLIKPTCTETMLAVKNITMHLLKKCP--------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M4P0-1", "uniprot_id": "F1M4P0_RAT", "id": "F1M4P0-1", "name": "Carboxypeptidase A6", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------MKFLGKPRSLTAAFLPVCCLLLKILQP------------------GHCHSYDNRYAGHKVIRLIPKSEEEALALKSVSHQLKVDLWQPSSISYVSEGTITDVRVTQNASRTLLAILQETNIQYKVLIEDLQKAVENENSVHTQ-----RNRRSLSEYN---------YEVYHSLEDIQSWMHHLNQTQPGLVRVFPIGRSFEGRSLLIIQLGRKSQV----YKRAVWIDCGIHAREWIGPAFCQWFVKEAILTYKTD-----------PAMRKMLNHLYFYIMPVLNVDGYHFSWT--HDRFWRKTRSRNSKFH--CRGVDANRNWKVKW-CDEGASADPCDDTYCGPFPESEPEVKAVANFLRKHRK--RIRAYLSFHAYAQMLLYPYSYKHATIP-NFSCVEFAAHKAVKALRSVHGIRYRHG-PASQTLY-----VSSGNSMDWAYKNG-IPYSFAFELRDTGYFG----FLLPEMLIKPTCTETMLAVKNITMHLLKNCP--------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8N4T0-1", "uniprot_id": "CBPA6_HUMAN", "id": "Q8N4T0-1", "name": "Carboxypeptidase A6", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------MKCLGKRRGQAAAFLPLCWLFLKILQP------------------GHSHLYNNRYAGDKVIRFIPKTEEEAYALKKISYQLKVDLWQPSSISYVSEGTVTDVHIPQNGSRALLAFLQEANIQYKVLIEDLQKTLEKGSSLHTQ-----RNRRSLSGYN---------YEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGRSYEGRSLFILKLGRRSR-----LKRAVWIDCGIHAREWIGPAFCQWFVKEALLTYKSD-----------PAMRKMLNHLYFYIMPVFNVDGYHFSWT--NDRFWRKTRSRNSRFR--CRGVDANRNWKVKW-CDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRK--HIRAYLSFHAYAQMLLYPYSYKYATIP-NFRCVESAAYKAVNALQSVYGVRYRYG-PASTTLY-----VSSGSSMDWAYKNG-IPYAFAFELRDTGYFG----FLLPEMLIKPTCTETMLAVKNITMHLLKKCP--------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F2H8-1", "uniprot_id": "E7F2H8_DANRE", "id": "E7F2H8-1", "name": "", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------MALRSTDVSSNVKSAVLLGCVLILCTAPNN-----------------VDSYLYNNRYVGDQVFRIIPSSKPEVQAVKQLFQNLTVDLWQPNSASLIRENSSIDVHVRRDKTHWLRNHLHQEHIYYEVLISNLQTEIEKQTGYRSS-----RKRRSELQYD---------YEVYHPLEEIQSWMFEMNRTHSHLVDLFSIGQSYEGRPLYVLQLGKRTRF----FKKAVWIDCGVHAREWIGPAFCQWFVKEALNSYQHD-----------SSMRRLMNQLNFYIMPVFNVDGYHYSWK--MDRFWRKTRSKIPKYH--CRGVDANRNWKVKW-CDEGASLHPCDDTYCGPFPESEPEVKAVAKFLRKHKK--RVKAYISMHAYAQMLLYPYSYKYATIP-NFNCVESAAQNAVSALYSAYGVRYRYG-PASSTLY-----VSSGSSMDWAYKNG-IPYAFAFELRDTGYYG----FLLPEALINPTCTETMRAVKTIASGLLRKCTK-------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VS66-1", "uniprot_id": "Q9VS66_DROME", "id": "Q9VS66-1", "name": "Peptidase M14 domain-containing protein", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------MKFSLGLLVLFLGATLVA----------------------AEQDYEGYRIYEVIPST---ADQADLLHQLSLQG--YDFISETRLLGHPSRVIVSPAQLKHFQQLVEAEKMTLTLVNSNLGASIAEEFAQRQM-----QRLLAPITGKGRLS-----TERYYTHEEIINYIDDLAQRFPSRVFVKTVGWSYEQRVLKTITITNGD---GKANKKVIFMDGGFHAREWISPAAVLYVIDQLVEQFE--------------ENAHLLKDYDWVILPLVNADGYEHTQTGTLARMWRKTRQPYTYAGQTCYGADPNRNFDFHW-NEEGASSNPCADTYAGPTAFSEPETITVRDLMHSLAD--RGIMYLTLHSYGNYLLYPWGWTSDLPE-NWEDLDAVARTGAEAIENATGTVYTYG-SSTNVLY-----IAAGASDDYGYYAG-FNVSITMELPGAGSIG----FNPPVTRIDEFVTETWIGIRAMAEKVIEMY---------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VS67-1", "uniprot_id": "Q9VS67_DROME", "id": "Q9VS67-1", "name": "Peptidase M14 domain-containing protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------MTVVWVILALSCLSLSAGLQR----------------------TNK-YEGYKIYEVSSEAR-SVAFSEALSELVKNASYYEVFSELN-AGNPGKIMVHPHEQVNFVQLMEENNVKYDIINRNVGLTLSRQFETNRM-----LRHWFPYNG--RLG-----TERYYNHEEINQFIEDLAGEHPRRVFLKTVGRSYEGRWLKTITITNGD---ARRNKNVILVDGGFHAREWISPAAATYLINQLVYNLE--------------DNADLLLDFDWVILPVVNPDGYEYTQLSEDTRMWRKTRKPSSSD---CIGTDPNRNFDFHW-NEEGASDDPCDNIYAGAKPFSEPEALVVGDLIHSYVD--RGQMYLTLHSYGSLILYPWGWTAAVPD-TEEDLHEVAAAGQSAIQEATGTIYKIGPSATTINY-----AASGASDDYAFNAG-FPISFTMELP-FGGTG----FDPPASDIDSIVKETWVGIAAMARKVIQKYPLA------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VS65-1", "uniprot_id": "Q9VS65_DROME", "id": "Q9VS65-1", "name": "Peptidase M14 domain-containing protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRNYHLEYKVLIEDLAPLVHAQRAENLR-----KKLLIQWPHIDVLS-----A--FYTHSEINDYLDSLLERFPKRVQVKQFGWSYERRPLKVLTITNGD---GRRNKPVILIDGTVHAREWISPSMALYIIQQLLDNYG--------------DNQELLQDYDWVIMPVVNADGYEYTHT--DSRYWRKSRRPTSNP--ECIGTDINRNFGYEWGHDEGSSSDPCENIYRGERPFDQSESQVLRDVMLHYKG--RLNFYLSLHSYGNYFLLPWGYTSDFPD-TYQDMMSVADAGAKAIIYSTNGIYSYG-STYYVLY-----PTSGDTTDFAFGVVNATVAMTMELPAAGFQG----FDPWISQIERLVTESWVGVRAMAAEVIRRYPS-------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VS80-1", "uniprot_id": "Q9VS80_DROME", "id": "Q9VS80-1", "name": "Peptidase M14 domain-containing protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWKILCGIVVLVTIVVNQLSEAREVRRR-----RGLMLQLDN-------------YLSYDGIMQYLDELALSHSNRVTLKDVARTYENRALKMAIITNGD---GRPGKRVIFLDAALHSREWMTPAAALLTIHKLVVEFA--------------ENSDLLTDYDWHIMPLANPDGYEYSRN--TERYWRNTRTPNGGN---CFGTNLNRNFAVDWNVGFPELKDPCDENYAGSSPFSEVEARTVRDIMHGLVESKRAVMYLSLHTANRSVFYPWVYDTDPVS-NQKEHDEIGRFVADRILQSTGTFIKTWQYAKYAG------TFGGTSMDYALLAG-FPLSFVFEMSGTGRDHVEYKFFPPARDIRHLAEESWTGIKAFAEKTIEKYPPSRVISYNPMVKLAENAATRNLGFNSMVATVCLFFTYLTNCNFF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VL86-1", "uniprot_id": "CBPA1_DROME", "id": "Q9VL86-1", "name": "Zinc carboxypeptidase A 1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLNKCLLFALLAIVASASVSAE-----------------------RVRYDNYRMYKVNSEN---AKQLEVLKDLEGSSDSIMFLDGVHLVGADIQIIVAPHKVPDFLEILGKSEIKYELQSRDVQKSLDEIDEKVAI-----KGRATTAYN----------WAQYYELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKPGIFLEAGIHAREWIAPAAATFIINQLLTSEVE-------------NIKELAENYTWYVLPHANPDGYVYTHT--TNRLWRKTRTPYG-S---CFGADPNRNWGFHW-NEVGASSSACSDTYAGPSAFSEIETLSLSKFIEG--LKGKVQLYLSLHAYSQYLLYPYGHTSDLPD-NVADFEKVFDASIAAVNKRYGTTYTGG-NIYDAIY-----PAAGASVDWAYGTQDVRMAFCYELRPSSTSYLT-GFKLPAEQIVPASEELLDSIVAMATEVKSLGYFD------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VL87-1", "uniprot_id": "Q9VL87_DROME", "id": "Q9VL87-1", "name": "Peptidase M14 domain-containing protein", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLLLLLLSVNILIFCLAE-----------------------RQRFDNYKVYRVSPVK---ANQLEGLRSLEANSEDALVLNNLHLG--PTDFLVAPDFDGTFLKLVKDLDLSPELIDANAQTSLSLDIEPIAD-----ANRRSDDYS----------WSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHND---GRAEKQSIFLEAGMHAREWIGPATATYFANELLSSQQQ-------------EIMNLARSYVWYILPHANPDGYVYTHK--TNRMWRKTRSPQDKN---CVGTDPNRNWDFHW-REVGASSDPCSESYAGPKAFSEPEVQTLSQFLKS--VPEPMFMFLSLHSFSQLLLYPYGHTSALPE-NHRQLEQIFNTAVGAMKRRYGTRYTGG-NVYDAIY-----PAAGSSMDWAYGVLNVKYSFTYELRPSGYSFWT-GFRLPAAQIIPTGQETTDSLVEMIKAAAQIEGYKIE----------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q0E9F9-1", "uniprot_id": "Q0E9F9_DROME", "id": "Q0E9F9-1", "name": "Zinc carboxypeptidase A 1", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------MGN------------KIINMPAARIGTQWLVILCVAMAASG-TNLDSGICPVAGDSGCRGNPPD-----QARYDNYRIYNVEFEN---QEQIELFQKLEEQSDSLTFIGHAREVGQKLSILVAAHRVADIADLLKTYKVKHRVLTYNFQEKIDRNLAEVQP-----ESIDASQLD----------WQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGVKLTS-N-----ANNKAIFIESGIHAREWISPAAATYIINQLLTSQDP-------------KVQQLAQDYNWIIFPCVNPDGYKYTFE--HDRMWRKNRQLFG-T---CRGVDLNRNYPDHW-NSTGSSSDPTRYDFAGPSAGSELETKRLIDFIRANAGKEQIKTYIALHSYSQMLMFPYGYTKERVS-NYDDLQEFGKKASAAIKAENGRDYVSG-SLFETIY-----PSSGGSMDWAHSEAGIPIAYTFELR-GPPDSQD-LFILPAVEIQPTASEAFTAIRAIVEAAAEKGYYK------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VCM8-1", "uniprot_id": "Q9VCM8_DROME", "id": "Q9VCM8-1", "name": "Zinc carboxypeptidase A 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------MYACQSALQENEMEIFYTDFKLRRIKMLPKGGTPKTWLLLLLVSSVCVIQESKASSFCTKADQCALDEEIKTAADSVQARYDHTRIYQVELAS---EEHVRLFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSYNVTHRVLNYNFQALIDANYLEVAP-----EDTKPEEFD----------WKRYHPLESINAWLKKLAETHP-EVLLVELGVSAQGRPILGVQIAFDN-----ENRTTVFVESGIHAREWIAPATATYIIDQLVNSKDS-------------AVQALARSQRWYIFPTVNPDGYQYTFK--GDRMWRKNRALFG-I---CRGVDLNRNFPFHW-NVTGASGDPCRYDYSGPSAASEVETQRMIEFIRHRVESERIRTFISLHSYSQMIMFPYGHSAERVD-NYHDLTDIGKLAANKIKDVSGRIYKSG-SIYETIY-----PSSGGSKDWAHGQLKIPITFSYELR-GPADSED-LFILSAKEIEPTAAEAFASIQTIVQEAGKRGYYQ------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W478-1", "uniprot_id": "Q9W478_DROME", "id": "Q9W478-1", "name": "Peptidase M14 domain-containing protein", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------MTQKTMLLQLLLLVAAVAASLANELPSN--------------LTLLDANEIPQRYDEAQLWRIYNIS----EAMQKRVPVGQMLEQKFGGNIWKENSKFLDISIARDQLKAARSFLSAHRLDPQILSHNIQSMIDEELLEGIQSSSFGHGRRTKKAARSSMH-----WKDYHDLETIYSFMREIRTKFPNIVRLYTIGQTAEGRDLKVLRISENP-----RENKKVWIDGGIHAREWISPATVTFILYQLMSDWEN--------------QPAHIRGLTWYIMPVMNPDGYEYSRT--TNRLWRKNRSPSRRAQ--CSGVDLNRNFDIGW-NGYGSSTNPCSDTYRGSAPASERETRAVAEFLAKRKYN--LESYLTFHSYGQMIVYPWAYKAVKVK-DASVLQRVSSLAAERILQKTGTSYRAA-VTHEVLG-----IAGGGSDDWSRAALGVKYVYTIELRDRGAYG----FVLPPRFIKDTALEGWTVVETVAQAIGPSSSG-------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W477-1", "uniprot_id": "Q9W477_DROME", "id": "Q9W477-1", "name": "Peptidase M14 domain-containing protein", "aln": "MHRLPWKWAWLPLLLLITAKLEQVGGKTYLDWARTDSQLTRLPFFGGGVGHLLRYLHPLSMSPPSERGKISELRSELDANYVSYRGAQLWKLNFNATRGSSMAEREEDDEAAEKRQVLASPDAQFNEVVALFALTFVALIGSVFGQKLLLWRSVSVPEISGISGLPLALLTLNSSELYESTLEGLQWLSPMDLRRFDFISPGSSYQINRRYRNGSQVQRYYGFQLWKVHETRLEQPELRAFWRHFGSEVWNINQDGIDILIEQRNVADARKFMDKVGYSYNIMIDDIESAIDESYVEVPAVEHPLDSVRNNSLPWMEVPGSTMNWRRYHDQADIKQFLQTLLETYSENVELIQIGVTRNKRPLEVIRVSNGN-----PDNWAVFVDAGLQARDWLSPAALTYAISKLTHLWGRPKGKDKGEGQRQSRAEKAMRRIDWYFLPLANPDGYQYSRQ--TDRLWTKNRGYDSVSG--CYGVNLDRNFDYGW-DGTGSTSNPCKNLYRGAHSFSEPESRAVCSFLSGMREY--LGAYVSLGGYGQAITYPWGDADYVTE-NQRNLKQTARRAVLALRRLNQAEYSSG-TSYRQKL-----ARPGNSADWVQDRIGPQLVFNMFLKDQGRYG----YLLPPHYIVESGEEVFEFLRIIAQQLQ------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38836-1", "uniprot_id": "ECM14_YEAST", "id": "P38836-1", "name": "Inactive metallocarboxypeptidase ECM14", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------MLHMNSLWGCFLFVLLAVTGAVQG----------------------LQEDYSEYAVYRFTSDN-----------YSTLVRDVIAPLTDDYDVWTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMARE-----QAVFENDYDF--------FFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPE-SNPEKKTIVITGGIHAREWISVSTVCWALYQLLNRYGSS-----------KKETKYLDDLDFLVIPVFNPDGYAYTWS--HDRLWRKNRQRTHVPQ--CLGIDIDHSFGFQW---EKAHTHACSEEYSGETPFEAWEASAWYKYINETKGDYKIYGYIDMHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGRNYDVISACKDRGSDIFPGLGAGSALDFMYHHR-AHWAFQLKLRDTGNHG----FLLPPENIKPVGKETYAALKYFCDFLLDPEI--------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VS64-1", "uniprot_id": "Q9VS64_DROME", "id": "Q9VS64-1", "name": "Peptidase M14 domain-containing protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------MWQGIVCSLALCLVGLAGLGIANNLAG----------------YEGYTKYTVQHGDENAFKYMVDLQTNDAELDFWLLTRNSSVLTVSPRRKTQFEASLSSLGVSYEMQPLMELMAALQANSSFADDNYDGEYEECQQDECEQAERPRRRTRRQARG--------FFSHYPRYHEVLSFMSGLAARYPQFCRYESLGRSNEGRHIAALSISLNSR---VRPRRVAYIQAATHGREWITTQTVLYLAYELLSNLR--------------AFTRVLQDVEIFLVPLVNPDGYEYTHT--TDRFWRKNRHRYAGHS--CSGVDINRNFGNHW-NYQGASQNLCSEVYSGTAPNSEPETSAVVRYLEFNRN--RVKLSLDVHSFGKFIFYPYGYAKNTVPPTVGTLRSVALRAANQIGRYRGTRYTTG-TSASILY-----EASGSLDDFAYGNLGIPLSYTLELPGDE-------FHVPAHDIIHVCKETFAGFIEFIRHVSLY----------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : :: : . . : : . : : . : :.*:*: : ..* * *** .: * * :.* * * : ::.: * : * . . * : : . . *: : * *: : : * * . . ", "identical_positions": 20, "similar_positions": 44, "identity": "2.84%" }, { "cls_id": "homologset.agr.HGNC:1725", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P48964-1", "uniprot_id": "MPIP1_MOUSE", "id": "P48964-1", "name": "M-phase inducer phosphatase 1", "aln": "---MELGPEPPHRRRLFFACSPTPAPQPTGKMLFGASAAGGLSPVTNLTVTMDQLEGLGSDCEK-MEVRNNSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLTRINSLPQKLLGCSPALKRSHSDSLDHDTFHLIDQDENKENEAFEFKKPIRPASR-----HIYEESKDPFTHRQNSAPARMLSSNE---SESGNFSPLFIPQSPVKATLSDEDDGFIDLLDGENMKNDEETPSCMASLWTAPLVMRRPANLADRCGLFDSPSPCGSS---TRAVLKRADRSHEEPPRG-TKRRKSVPSPVKAKADVPEPAQLP-SQSLSLMSSPKGTIENILDSDPRDLIGDFSKGYLFNTVSG--KHQDLKYISPEIMASVLNGKFAGLIKE---FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKNPIVP--------TDGKRVIVVFHCEFSSERGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHED----FKEDLKKFRTKSRTWA---------GEKSKREMYSRLKKL------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P48965-1", "uniprot_id": "MPIP1_RAT", "id": "P48965-1", "name": "M-phase inducer phosphatase 1", "aln": "---MELGPEPPHRRRLLFTCSPTPAPQPTGKVQFGASRAGGLSPVTNLTVTMDQLEGLGSDYEKPMDVRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQKLLGCSPALKRSHSDSLDHDIFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDISESGNFSPLFTPQSPVKASLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRCGLFDSPSPCSSTSSCSTRAVKRADRSHEESPRG-TKRRKSS-EASPVKADVPEPTQLP-HQSLSLTSFPKGTIENIFHSDPRDLIGDFSKGYLFHTVSG--KHQDLKYISPEIMASVLNGKFANLIKE---FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPIVP--------ADGKRVIVVFHCEFSSERGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHED----FKEDLKKFRTKSRTWA---------GEKSKREMYSRLKKL------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P30304-1", "uniprot_id": "MPIP1_HUMAN", "id": "P30304-1", "name": "M-phase inducer phosphatase 1", "aln": "---MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMR-TTNLDNRCKLFDSPSLCSSS---TRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAG--KHQDLKYISPEIMASVLNGKFANLIKE---FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP--------TDGKRVIVVFHCEFSSERGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHED----FKEDLKKFRTKSRTWA---------GEKSKREMYSRLKKL------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q03019-1", "uniprot_id": "TWINE_DROME", "id": "Q03019-1", "name": "Cdc25-like protein phosphatase twine", "aln": "MASKRLMLDVEEEDDESGACGQENFDPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQN----MNGARLDGTPKSTQRIPANRTLNNFNSLS----SRTLGSFSSSCSSYESG-NSLDDEYMDMFEMES-AENHNLELPDDLE----------------------------VLLSGQLKSE---SNLEEMSNKKGSLRRCLS------------------------MYPS--------------------EQPE-------------------------EAVQE-------PDQETNMPMKKMQRKTLSMNDAEIMR-ALG-----DEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTS-------NQEN---RRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPA----HNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRLLYAE--------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P20483-1", "uniprot_id": "MPIP_DROME", "id": "P20483-1", "name": "M-phase inducer phosphatase", "aln": "----MLWETIVEENNCSMDCNISNNTSSSSSINKMSGSRR-ARRSLELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSME-SSMDDEYMELFEMESQSQQTALGFPSGLN----------------------------SLISGQIKEQPAAKSPAGLSMRRPSVRRCLS------------------------MTESNTNSTTTPPPKTPETARDCFKRPEPPASA--------NCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAEIMS-ALARSENRNEPELIGDFSKAYALPLMEG--RHRDLKSISSETVARLLKGEFSDKVAS---YRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPA----YNEAYRHFRAKSKSWN----GD-GLGGATGR-LKKSRSRLML----------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P23748-1", "uniprot_id": "MPIP_YEAST", "id": "P23748-1", "name": "M-phase inducer phosphatase", "aln": "-------MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENE---NENDDIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQ------------------------------RSSSFSRSRSLSRKPSMNSSSNSSRR----------------------------------------------------------------------------------VQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKCFESCLAKTQIPYYYDDRNS---NDFFPRISPETLKNILQNNMCESFYN--SCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHS----DTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .. . . : : :. : : : . : : . : . *.. : . .:. : .:. . : . :.. . : : **.: : :::.:: . . *****: **: **** .: *:: :: : : ::******.*** : .:* :* . ** * **:: :*..*** .* . * * * * :: ** ::: : . : .: ", "identical_positions": 42, "similar_positions": 84, "identity": "6.13%" }, { "cls_id": "homologset.agr.HGNC:17255", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6G9X6-1", "uniprot_id": "A0A8I6G9X6_RAT", "id": "A0A8I6G9X6-1", "name": "", "aln": "---------MWNNIELLTSDDTGSGFLNVGSRKESVTALYQVDLLGKISS-EKTSLSPKIQACSLSDGFIIVADQSVILLDSTCRSLQLFLIFDTDVDVVGLCPEGKFLFVGERSGNFHLIYVTSKRTLFTKAFVEKAEDE--RTYRSLVIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTESYHSSGCLNLLASQSGKFANETSVIIGGTGSCAFSKWEPDSTKKDMSLKNFVDTDIIRGAKSFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPIEQFLLTTEADSPSSVTWQGITNLKLVTLTAT-TKEKMRNLIIYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVHKNDPNLCEDSVSNLELRYLTEVLPENRLSRLLHKHRFADAESFAIQFGLDVELVYKVKSNDILEKLALIS-DKSEQSEWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRTLPACSDDFLEVLKAHAKLTTFYGAFGPEKFSGSAWVEFLNNEDDLKDIFVQLSEGNFDCAQYLWLRHRADFESKFDVKMLENLLNSISTQIPVEKLCSWFKNDVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDKFGFSSSWHWISLKDYQNTEEVQQLRTLVSKLQELIILHRKYNCRLALSEFEKENATTVVFRMFDRVSAPELIPSVLEKFVRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVRQHLEMDHPKVKLLQESYRLMEMKKLLRGYGIREVNLLN-KEIMRVVRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRVIDLIDRDQGEDCLLLLRSLPPSEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSMDILKILCDIQKDNLQKKDDAEEFLKRFKMVASLQENFEVFLPFEDYSDTGLVAGLREQYIKAQENAQAEHKFR----------------GPPGPTPAMGTNASVKSKLHRQALVLQVSTQELEAEMALRALKDGKVAVALSKCRDLLKHYCNADTGRLLFVVCQKLCHMLADDVPMVAPVGLNLPSEIHDLTCHAVTICSPDFLLDVLELSKYTLTAVELCRQCQMDDCGILMK-AAVGTHKDPYEEWSYSDFFSEDGIVLESQVVLPVIYELISSVVPLAEGKRRPLDSISLPYCSTSEGENLILPLVSSISALLRNLQESSQWELALR--FVVASFGTCLQHSVSNVMSMSLSEKLLGKSTLASSRQIIMELKEKSIAFIRGS----ATTLLHKVFN--CRLVDLDLALAYCTLLPQKDVFENLWKFIDKAWQNYDKILALSLVGSRLANLYQDVETGLRFHELSIDAKWGIRLGKLGISFQPAFRQNFLSKKDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRN--------TTS-QSQGGDAPEPTQHQHSKLLQKATEMVPLLKSTKDLVISLTEILYKLDPYDYEMIEVVLKVIEQANEKITTVNINQ-ALNLLRHLKSYRRMSPPVDLEYQYMLEHLIT---LPPAAQTRLPFHLILFGTAQNFWKILSSELSEESLPTLLLISKLMKFSLDTLYVSTAKHVFEKNLKPKLLKSAQARSS-VMSKEVDKLVQTLESYLLSIVNPEWAVAIAISLTQEIPEGPFKMTSLKFCLYLAERWLQNIPPQDETCEKVKALQKKLYLQFRLSGTEAVLIAHKLNDQEYLRVVGKPAHLIVSLYEHPSISERLCTTSGKDYPDIHAAAKEIAEVNEINLEKIWDMLLEKWLCPSTAPGEK----ASEFFELEEDEVLHR-VVYLLQARPIDYSSRMLFVFATSATSTLG--IRQLTFAHRAR--ALQCLLYLADKETIESLFKKPTEEMKSYLKCITFLASFETLNIPITYELFCN--SPKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSVHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCESLVAILECPVSDDLDMMGVAKQYVQLELPAFALTCLTLMPHSEKRHQQIKNFLNSCDAQIILQQLEEHMNAGQLAGLSQQIRSLVLNHVVNKKEFGILAKTKYFQLLKRHVIN---TDNVTELVNYLANDLSLDEASSLITEYSKHCG----KPVPADTAPSEILKTFLGS-----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C3Y4-1", "uniprot_id": "KNTC1_MOUSE", "id": "Q8C3Y4-1", "name": "Kinetochore-associated protein 1", "aln": "---------MWNNIELLTSDDTGSGCLSVGSRKENVTALYQADLLGKISS-EKTSLSPKIQAFSLSHGFIIVADQSVILLDSICRSLQLFLIFDTDVDVVGLCQEGKFLFVGERSGNFHLIYVTSKQTLFTKAFVEKALDESQRTYRNLIIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTENYHS--CLSLVASQSGTFASKTSVIIGGTGSCAFSKWEPDSTKKEMSLKNFVGTDIIKGAKSFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPVEQFVLTTEADSPSSVTWQGITNLKLVTLTAT-AKEKMRSLIIYSLPSMETLYSLEVSSVSSLVQTGISTDTIYLLEGIHKNDPNLCEDSVSDLVLRYLTEVLPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDMLEKLALISSDKSEQSKWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRALPASSDAFMEVLKAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLRDVFLQLSEGNFACAQYLWLRHRADFESKFDVKMLENLLNSISTQFPLENLCSWFKNEVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDRFGFASSWHWISL-DYQNTEEVRQLRTLVSKLRELIILHRKYNCKLALSDFEKENATTVVFRMFDRVSAPELIPSVLEKSVRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLN-KEIMRVIRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRIIDLIDREQGGDCLLLLKSLPAAEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSVDILKILCDIRKDNLQKKDESEEFLKRFQMVASLQENFEVFLPFEDYSNTALVAGLREQYIKAQEAAQAEHKHR----------------GPPGPTPARGTHLSIKSKLHRQALALQVSEQELEAELTLRALKDGKVVAALSKCRDLLKHYCNADTGRLLFVVCQKLCQMLADDVPMVAPGGLSLPSEIHDLACHAVTICSPDYLLDVLELSKYTLTAVELCRQCQMDDCGMLMK-AALGTHKDPYEEWSFSDFFSEDGIVLESQVVLPVIYELISSVMPPAESKRHPLDSISLPYCSTSEGENRILPLVSSISALLRSLQECSQWELALR--FVVGSFGTCLQHSMSNVMSISLSKQLLGKNTLANSRHIIMELKEKSITFIREN----ATTLLHKVFN--CRVVDLDLALAYCTLLPQKDVFDNLWKFIDKAWQNYDKILALSLVGSQLANLYQDIETGLWFHELSIDAKWGIRLGKLGISFQPAFRQNFLTKKDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRN--------TSS-QSQGDAAPESTKHQHSKLLAKATELVPLLKNTKDLVISLSEILYKLDPYDYEMIDVVLKVLEQANEKITSVNINQ-ALNLLRHLKSYRRISPPVDHEYQYALEHMIT---LPPAAHTRLPFHLILFGTAQNFWKILSSELSEESLPTLLLIAKLMKFSLDTLYVSTAKHLFEKNLKPKLLKSAQARSSTLMSKEVDKLMQTLESYLLSIVNPEWAVAIAISLTQEVPEGPFKMSSLKFCLYLAERWLQNIPPQDETCEKAKALQKKLCLQVRLSGTEAVLIAHKLNDQEYLRVIGKPAHLIVSLYEHPSISERLCTTSGKDYPDIHTAAKEIAEVNEVNLEKIWDMLLEKWLCPSTVPSEK----ASEFFELEEDEVLHR-VVYLLQARPVDYCSRMLFVFATSATSTLG--MRQLTFAHKAR--ALQCLLYLADKETIESLFKKPIKEMKSYLKCITFLASFETLNIPITYELFCN--SPKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCDSLVAILECPVSDDLDMMGVAKQYVQLDLPAFALTCLTLMPHSEKRHQQIKNFLNSCDARIILQQIEEHMNTGQLAGFSHQIGSLVLNHVVNKKEFGILAKTKYFQLLKCHVIN---TGNVTELVNYLANDFSVDEASALINEYSKHCG----KPVPADAAPCEILQTFLGGS----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P50748-1", "uniprot_id": "KNTC1_HUMAN", "id": "P50748-1", "name": "Kinetochore-associated protein 1", "aln": "---------MWNDIELLTNDDTGSGYLSVGSRKEHGTALYQVDLLVKISS-EKASLNPKIQACSLSDGFIIVADQSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKQTLLTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYMLLLTYSGFFCITNLQLLKIQQAIENVDFSTAKKLQGQIKSSFISTENYHTLGCLSLVA---GDLASEVPVIIGGTGNCAFSKWEPDSSKKGMTVKNLIDAEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLIALTAS-ANKKMKNLMVYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVCKNDPKLSEDSVSVLVLRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNHILEKLALSSVDASEQTEWQQLVDDAKENLHKIQDDEFVVNYCLKAQWITYETTQEMLNYAKTRLLKKEDKTALIYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLKEGNLVCAQYLWLRHRANFESRFDVKMLESLLNSMSASVSLQKLCPWFKNDVIPFVRRTVPEGQIILAKWLEQAARNLELTDKANWPENGLQLAEIFFTAEKTDELGLASSWHWISLKDYQNTEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDKVLAPELIPSILEKFIRVYMREHDLQEEELLLLYIEDLLNRCSSKSTSLFETAWEAKAMAVIACLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLN-KEIMRVVRYILKQDVPSSLEDALKVAQAFMLSDDEIYSLRIIDLIDREQGEDCLLLLKSLPPAEAEKTAERVIIWARLALQEEPDHSKEGKAWRMSVAKTSVDILKILCDIQKDNLQKKDECEEMLKLFKEVASLQENFEVFLSFEDYSNSSLVADLREQHIKAHEVAQAKHKPG----------------STPEPIAAEVRSPSMESKLHRQALALQMSKQELEAELTLRALKDGNIKTALKKCSDLFKYHCNADTGKLLFLTCQKLCQMLADNVPVTVPVGLNLPSMIHDLASQAATICSPDFLLDALELCKHTLMAVELSRQCQMDDCGILMK-ASFGTHKDPYEEWSYSDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLESTSLPYCSLNEGDGLVLPVINSISALLQNLQESSQWELALR--FVVGSFGTCLQHSVSNFMNATLSEKLFGETTLVKSRHVVMELKEKAVIFIREN----ATTLLHKVFN--CRLVDLDLALGYCTLLPQKDVFENLWKLIDKAWQNYDKILAISLVGSELASLYQEIEMGLKFRELSTDAQWGIRLGKLGISFQPVFRQHFLTKKDLIKALVENIDMDTSLILEYCSTFQLDCDAVLQLFIETLLHN--------TNAGQGQGDASMDSAKRRHPKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQ-ALSILKHLKSYRRISPPVDLEYQYMLEHVIT---LPSAAQTRLPFHLIFFGTAQNFWKILSTELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLKLTQAKSSTLINKEITKITQTIESCLLSIVNPEWAVAIAISLAQDIPEGSFKISALKFCLYLAERWLQNIPSQDEKREKAEALLKKLHIQYRRSGTEAVLIAHKLNTEEYLRVIGKPAHLIVSLYEHPSINQRIQNSSGTDYPDIHAAAKEIAEVNEINLEKVWDMLLEKWLCPSTKPGEK----PSELFELQEDEALRR-VQYLLLSRPIDYSSRMLFVFATSTTTTLG--MHQLTFAHRTR--ALQCLFYLADKETIESLFKKPIEEVKSYLRCITFLASFETLNIPITYELFCS--SPKEGMIKGLWKNHSHESMAVRLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLKAISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLSPDQLSDCSESLIAVLECPVSGDLDLIGVARQYIQLELPAFALACLMLMPHSEKRHQQIKNFLGSCDPQVILKQLEEHMNTGQLAGFSHQIRSLILNNIINKKEFGILAKTKYFQMLKMHAMN---TNNITELVNYLANDLSLDEASVLITEYSKHCG----KPVPPDTAPCEILKMFLSGLS---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B017-1", "uniprot_id": "A0A8M3B017_DANRE", "id": "A0A8M3B017-1", "name": "", "aln": "MKQQSRFLKMWNNVELLLNEDTNTVRLYNDVEQESGNALYQVDNLVKISSSEKVVSKPNVYASSTPNCCIIVVDTAVVLFDPGFQTVLIHLYFDSVVDAVTVCPQGQFLLVGERNGSLHIIYIPLKKTVLTKNLPQQKSSCGETTFKSLILHEKPGSKGDYDLFFVIKDGFLHVSNVALGKIQRAIENMDLVVLNKIQEDILMNFFSTKEIHEDGCISASL---VCFGSTSHLLIGADGANVLSLWSMGLHQTSMSLTKLLDSSLMSEVKKVQVVDNLMYVLNNEGMLSMLDIHSFVMLCCWPDQYIVDFLLISDGNS-SSITQQDDNTLKIMTLVVEGNKDHSRKLVVQSLSSMEVFYSLEVSSESWLIQKGISMDTIYLLEGVLANTKSSPEDPVSTVVIRCFTEALPENRLNKLLYKHKFEEAEKFAKTFGLDVELVYKVKLNVVLEKLISAS-GNDQTIEWPELIQEAKTNLMKIMDEQFVVQYCLSASWPTLSIAEEMLNYTLNRFP-------------CCQIQTALAKLATFSSMYGPNNFDGIKWIEFLNSTDYLKDILALLKEGNVNGAQYLWLRHEGEFASEFDEACFHALLSSISSDIPSQDLIPWFKGVVVPFVWRVLPKGQKIIARWLEHRARNLELTEKSDWPQNGLLLAEL----------GLPSLWRSMGLAEICGAEEVESLRSLVANLRQLCDLYIKYNCHLSLSDYERGSTRSMAFLMLDKVQAPELIPAVVESSVEPYALENGLDLDQTLLDYIKDLLDCCSSQITSLF-TEWEAKAVAVLHCMKDTNKVMDAVIEIMYKAVVPWSDTIEKLVQLHLEKEHPKQELLREGYRLMEIKKLLRCYGIRSLALSNSRDIMMLVRYILKQDLPTSLEDSLKLIEAYKLNPAEFHHLHCIQLIQRNKREKCTTLLKSLPHSEAIFVIERMACWARLELQDKQHISEEQKKLQMLISQIMVEALKYLQSIQTDDAFKKTECENNLKMFTAIAHLQEDFDIFLTPEEYDDPVVRHKFNQQLITAYENTQAWRRSGKQHPDKVSDSNLNGSAAVANDPDGKTKSLSTEAGLHRLARQLQKTEQELWADLALRALDAGNVEKALQILSELYQHHSNCSTGRVLFSTAQRLCQMLEENVPMVLPEKTNLPAVIHRLACQAITVCHSDLLLDCLELCKSTRTAADVYRQCQIEDFGFFAKESSMSGEEDAYAESHFHDVFNEDGIVLDPVSVLPLQYKITRNLLPLSESRLFPFDCSCLSYCSTKEDAELVGPLLNPMASMLQMLQECSQLELAVR--LLMESYGSILLHFVSNNMDISLSKRLQSNNRMARDKQTLDKIEKTVLSSVSVV----VVSLLQKVLN--WRVVDSDLAIGLCTILSKAAVIDILWKIINSAWQNYDKIKVVAMVGAHVSFLYKDEEERGKFVSVITDAEWGVQLGRLGVSIQSVFRQCTETKRNLIPTLVKNKNITPDIILHYCSTFGLDSYSAINLYITTLLLQEDRWYEMEIEEGDAESSLRIQESLRGKDDMLESALQIIPQLGSTKDLVISLNTALTKLNPYNYEWIERVLKTIQMADESTTLIPLGQ-MVGLLQHLKSHRRISPPTDLESSYLLENSLE---PTALANTRLPFHLLFQ-SSHAFWKIVSPELSEETLPTLLLICKLMKVNLDKLYVLAVNHVFKKSLLPLLMDQTKKIQHLGSSKELCSVTDSVFQHALCIQNLELAAATVHKIAQDLPAGAVKTDFLKFSLDLVHKLLKSDTLEESLQARGEALISKLQLQYQRSATENALLSSQLGSPELLKLTGLPGRLIVALFEHSSVLDRMKNPAGQTYPDIHSVASEIASINSVDLLKIRNILLEKWLCQTGQSNGKDINHQDNVTDVNDDPDLMR-VVYLLQMHPMDISARLLSPVLTSQTWPLGGSGLRLTFEHRSR--ALLCLTHLTDAATLETLSNQPSSKIKYYLKCYMYLAQMEALNIPYTLDMFIS--SPKEGMIKGLWKNHNNEPQAVRLVADLCLEYGVYDLQLWNSVLQKLISFNMTSYLQKVLEALIAVPSLLEGQSLSRIWRSVIQAPFLTASLPLSPQQHMVMYKTFVLLLKCPFLFTLDLVAIAKRFSQFSLQAFSLGTLLLIPCLKKKEPQIQSFLLSCNPTLILDQTEESMATGELAGIPSQIRETVFAFLCQNGKSQTLLKTKHFTYLKRHLISKGRSEAVLELLNCLVEQKGEDEAICFANEYLQYRDLKGEKTAPVSDPFSDPVRDLLEKVLESRGTQTVT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V9W7-1", "uniprot_id": "Q9V9W7_DROME", "id": "Q9V9W7-1", "name": "", "aln": "---------MWSNFEASS------------LEDETISNIFSSRGIFQISSEEEVNKYPDVMASVQCGKMVIGIDKSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKG-LLLFSVAVNLEDVSLTGGTFRSIHQLDQRFYFTCKNGSIYSLSDIDETCLETLGNMSLNENETIACEKALLEDVTIQRLSKGRSSCSVDCAVLLKR---LLTGNISAENNQDDLEAQPGLVITGDQSTMNFRNAANDVTRINLPAQYGSLKQIFNLEH-YIIALTDSGHLVEICPYTRTVYMCQTTQQKNLLIEDLLVMECSEDNIELLVLTKSTAEGRFIKIVEYPTLNVKNEVEVPDHAWLVRQPKCAVNLYYLAAKEVNQSSIP----SVVEMMLVSETDPSDRFKKLICKGRLEEAEEFGKQFELCLQPIYEAKAKRILVELCNSN-----SQNVDTKFQDLLQLLSQVESKAFIKSHRMIN-LNSRHILERYLHEVKKRLTFEDDE------EDMLEIDEQLHRLKTLA-IIDPYECN-TDWQKFIYDNN-LVRMVKSLFNTDMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPFNVVQWLR-QFIPMVSNTHPSIMPFITDWSIEMTRNLQYS--PHWPDIGLEFCTKILD-------IFEEIQFTYSDVRRQQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSILQHVQLDKLQR-LVKNFMYPIFQEKGRQPLDVIKQYISQLVASRLSS------SSWLDRAMACIELLHNEDSRLECALSVLQNAPVPWPDTLAPLIRLR-ASTHPLAVKINAEYEIQVIKIMKVKYGWPADSSDINLELFMMR--IVKLNLPDMLDDISALTKAAPELSTSANFNCCYQMARRGQVEMAYEFFKKLNGEKNSKSAKEVVEIMANILENSSSASFES-DIKVQEHLNVLELFKLFLPHVESVYERRYLVIKHRFRLRKFGILLSCSSELIPLHRR-HCLLDEAIERIIERAQATLNVSAFIAS--------------EISELCTALGLPKVFGLHRICQRIGCLPLSCALAYHVVSFVDCVPANAGEFVNLALELLVQQIESAKGKNQETASSLQLINENDPLSFYLAYELLTSALLHESSRRHDLVELIKYIR--VAVIHYPLDAIKSHYDGKEQAVNEHIC-RALDGISVALGETTINFSCALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQ-KKSVGGRMAIVKFLARTLLLMVIETEPNNSLLMQVRNELPENTKADVESACADFFLSLEHLTKVKEHDAWYVMSQYLLDFQKQNCRTKRIINEGFITLQLRRIFRNAMGSKDVNFIELFTMLVVDSEALALLEKLSVEVKTDLQKINFLTLS-AMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQDHRIKGKFNADMDNIEDLLKEFHN-KQLDVQLLERMSKDFGFDYQKILITQILSILSAQELR----FEVKRDTFGDEELVMLSSAQEMRDMCQPYINEINNVELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKEMEIWMNILHFLRHKMITRRRNRPGQVETDTWLKSQRENGVMPKISRYRLPFKPIVEQPLKDILDSELNVDNCQSWFPLIQMYTALKGSKDSSQNCDYFCMSAVKNSISEYKSKNDSESWSLHPTNNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEKGHLITD-----PKSREQVAKVKRRYPIQKTQHLLYVYGLTDEKLLRQVENPTELIQALYHHELILK-------SSKVDINALVAEIAKLHDLCLATIQYRLLQKWLALTMESAGDGTILEETFMEEQNWPEQANGAESSNSQDASENVNRAFYILSSWPKAEAVKFLVGLIFKGGSVNTSTQLQMYECYSKLNDGSNSFTNTISQRQFISIKCVHELKALGYKSNLEKFSDDHCNKIDILKMIWQRNAQNPLSLEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDGLAQAWDYVLCHPLQNAVELRSFKQEEVLHKTLLRLQGCPVVHALNLLQFAQLCIVVHRPHMAASLLSFCQSSEQR-QKIKKMIHSHPVENLRQQILDLEDAGILP--------VVLNFALKELNL---------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **.:.* ..* . ::. : :*** *:. *.: * :* * :::*:: : .* *.: ::.: :. .*:::. * .*..* :.: ::: . : . *::.: .. : ..: * ::. :: :: : . .. * : . . . . . :. *.. : . : :: *: :::: * :. : :. . ..: . :: *. . . : : : . .::: .:**.. : *:: . .:* * . * . * : : .:*. *.:*:.:*: * :: :**.*. * * :: :*:.* : :* :* . : .:: * :: .. *: .. : : :. * . .*: :: :* *: .* : . * :*: . : * :. * : :. * :* ** ..: . :: :. **. :.:. .: *:: .:*:* . *. ::: * . :***: : ..**: ** :. : . . .:* .** ** *::* * :** ::*.:: : . : .: ::::* :* :::. : *:. : : : **.:*: *. : * :*:* : : : : ::..:.:: * ***. :: *:: : ** :. *.: :* : ** ::: : *:* ::* *:* : :. . :: * : . :::.* : :.: *::. * * :: :: :* : . :: : : .. * . . ::. . . : :.. * :. : : * : ::: .: :. :* :. .*: ... : :.. . .: :* : : : . : : : : . * . : : : . :.. . . * :* . .:* : .: * . *:: * : : .: :: : .. : :* : : . . :. :: . : : .::: . *::::. * :: :: . .: * *: .. : :** ::: : :: : : . : :.: : . :: *. . .:*: : : :: .:: . .. * :* : * ::* . .: . : : ..: :. .*. : .:: * ** *:: : :. . : : : :*:* ** . * : * . *: . :. ****: :. . : : . . :: .*: : . :* . *. : . . : . . ::: : * : * ::: *. : . :... : . : . *: : . *: * * : *: * .** :*:.* : . **:: . ***.::.: * .: **:***. : . . . . : :: . . . : * : . : . * * : : : : . . : : . : .:::*. . : * . . * .::* :*:.: ::. ::.:::::** : :: *:**.:*:::: *:* *. :*. : . * . ::: * *: *: .* .* .::: : **. *::: .*: . :: * : ::: :*:.:: * : .* : :* *. :: :: : ", "identical_positions": 222, "similar_positions": 682, "identity": "9.7%" }, { "cls_id": "homologset.agr.HGNC:17256", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q641P0-1", "uniprot_id": "ARP3B_MOUSE", "id": "Q641P0-1", "name": "Actin-related protein 3B", "aln": "MAGSLPP-CVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IRESAKVVDQAQRR----------------------------VLRGVDDLDFFIGDEAIDK---PTYATKWPIRHGIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVREFAKYDVDPRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQSCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6GL35-1", "uniprot_id": "A0A8I6GL35_RAT", "id": "A0A8I6GL35-1", "name": "", "aln": "MAGSLPP-CVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IRESAKVVDQAQRR----------------------------VLRGVDDLDFFIGDEAIDK---PTYATKWPIRHGIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINQRKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVITHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9P1U1-1", "uniprot_id": "ARP3B_HUMAN", "id": "Q9P1U1-1", "name": "Actin-related protein 3B", "aln": "MAGSLPP-CVVDCGTGYTKLGYAGNTEPQFIIPSCIA------IRESAKVVDQAQRR----------------------------VLRGVDDLDFFIGDEAIDK---PTYATKWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B9D0-1", "uniprot_id": "A0A8M2B9D0_DANRE", "id": "A0A8M2B9D0-1", "name": "", "aln": "MAAARPPPCVIDCGTGYTKIGYAGNTEPQFIMPTCIA------VRESASVGDQAQRR----------------------------LVKGVDDLDFFIGDEAIDK---PNYATKWPIRHGIIEDWDFMEKFMEQVIFKYLRAEPEDHNFLMTEPPLNTPENREYLAEIMFETFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHAIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREIGIPPEQSLETAKAVKERYCYICPDIVKEFTKYDMDPGKWIKKYKGINAISKNEFQIDVGYERFLGPEIFFHPEFANPDFMQPISDVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPMEVQVISHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPRICRHNPVFGIMS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P32392-1", "uniprot_id": "ARP3_DROME", "id": "P32392-1", "name": "Actin-related protein 3", "aln": "MAGRLPA-CVIDVGTGYSKLGFAGNKEPQFIIPSAIA------IKESARVGDTNTRR----------------------------ITKGIEDLDFFIGDEAFDA---TGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVFGTMT", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P47117-1", "uniprot_id": "ARP3_YEAST", "id": "P47117-1", "name": "Actin-related protein 3", "aln": "MSYLNNPAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAAPSNTKKSSGVGAPSAVSNEASYFGNSTSATNFNGATGGLLSNNLSGKRGTEDLDFYIGNEALVASQGPSYSLSYPIRHGQVENWDHMERFWENSIFKYLRTEPEDHFFLLTEPPLNPPENREQVAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSAIKNIPIAGRDITLFIQSLLRERGE---ADTSLRTAEKIKQEYCYVCPDIVKEFNKFDKDPSKFA-QFVVENQEKTRRKVVDIGYERFLAPEIFFNPEIASSDFLTPLPTVVDQTIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDLKSIVNNRIAQSELLSG--TKSTGVDVSVISHRKQRNAVWFGGSLLAQTAEFKGYCHTKKDYEEYGPEIVRNFSLFNMV-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: . *:* *** :*:*:*** .*.:::*:.** ::*: * :* :****:**:**: . *: .:*:*** :*:** **:* *: :*****:***** **:******.***** ***:**:** .****************:* .. :*:*** *:********.***********.**:******:** ***.***** .: **.**: :*:.:**:****.:** *:* :* *: :: * . :*:******.*****:**::..** .:. :**:.** ******: **:*:*********:*********:* *: *: *: ** *.. ::*.*::*: ** *******:**.*.** **** ****** * *: .:*. : ", "identical_positions": 229, "similar_positions": 103, "identity": "50.22%" }, { "cls_id": "homologset.agr.HGNC:17257", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B2RYE0-1", "uniprot_id": "B2RYE0_RAT", "id": "B2RYE0-1", "name": "SAM pointed domain-containing Ets transcription factor", "aln": "-----------------------------------------------------------------------------MGSASPGLSNVSPG-CLLLSPDVALRTGVEKAASG-------AMGLEKQEWSPSPPATPEQGLSAFYLS---YFN-MYPEDGSWVAKVPEASAREDHPEEPE-------------------QCP--VIDSQASGN---------TLDEHS--------------------LEQVQSMVVGEVLKDIETACKLLNITADPGDWSPGNVQKWLLWTEHQYRLPPAGKAFQELGGK--ELCAMSEEQFRQRAPLGGDVLHAHLDIWKS------AAWMKERTSPGALHYCAATHPARPGFLPASTSEEG--------------WTDGEVDSSCS------------------GQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGVRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPV--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WTP3-1", "uniprot_id": "SPDEF_MOUSE", "id": "Q9WTP3-1", "name": "SAM pointed domain-containing Ets transcription factor", "aln": "-----------------------------------------------------------------------------MGSASPGLSNVSPG-CLLLFPDVAPRTGTEKAASG-------AMGPEKQEWSPSPPATPEQGLSAFYLS---YFN-MYPDDSSWVAKVPEARAGEDHPEEPE-------------------QCP--VIDSQASGS---------TLDEHS--------------------LEQVQSMVVGEVLKDIETACKLLNITADPGDWSPGNVQKWLLWTEHQYRLPPAGKAFQELGGK--ELCAMSEEQFRQRAPLGGDVLHAHLDIWKS------AAWMKERTSPGTLHYCAS------------TSEEG--------------WTDGEVDSSCS------------------GQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGVRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPV--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95238-1", "uniprot_id": "SPDEF_HUMAN", "id": "O95238-1", "name": "SAM pointed domain-containing Ets transcription factor", "aln": "-----------------------------------------------------------------------------MGSASPGLSSVSPS-HLLLPPDTVSRTGLEKAAAG-------AVGLERRDWSPSPPATPEQGLSAFYLS---YFDMLYPEDSSWAAKAPGASSREEPPEEPE-------------------QCP--VIDSQAPAGSLDLVPGGLTLEEHS--------------------LEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAGK--ELCAMSEEQFRQRSPLGGDVLHAHLDIWKS------AAWMKERTSPGAIHYCAS------------TSEES--------------WTDSEVDSSCS------------------GQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P29775-1", "uniprot_id": "ETS4_DROME", "id": "P29775-1", "name": "DNA-binding protein D-ETS-4", "aln": "MEYEKMLYMPAASEMPHSPQLKPHQFQAHTPTDQYSSYADNFDLSLLPQESASIPTTVFQYNAPQIKVECAWDSQPIQQQQQPTAPYTNPSSHQLIPPPAYPHSAYPSPQSSPLQSEFAAYGLGRFGGSYDSLNSPSPSLEAVSIKQELHILPPSPPESNCETPSPRSSCGESIKAEPLDADIESLIDLNSLLQQQSLQSPQNLQDTKPDHQLLRECLEDTSFQKRHNLKPLALESFIGGLAEVRGDFEPVISLALEHAKREADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPPVADLELHFCENGAALALLSEEEFVRRLPESGSTLHAQLEIWKMAYADQPAHQQHSQQSASTDHWPASYAMPHLDLDYNEDSEDDDDMEADAQVAPLNGSTTSPPATNASNGGTATVKRPNGGRTGGGGSHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQFCHPYSQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .* . ..*. *: * . ::. .. :. * * : * .. :*. .*.*. :. :: * :.. : * : . *. ** *.* : *::. ::::: :* * *:.: .. :: :: * *:*: ** .***.:*: ** * *:**** .. .: : *. :***:* :* * .*..***:*:*** * :.: *..: *: *: **:. * . :..* *. *********** .*: * ***:::.*********.:**:*** ************************::*.: ******** ** ", "identical_positions": 127, "similar_positions": 103, "identity": "24.52%" }, { "cls_id": "homologset.agr.HGNC:17258", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0L4P2-1", "uniprot_id": "A0ABK0L4P2_RAT", "id": "A0ABK0L4P2-1", "name": "Cytosolic carboxypeptidase 1", "aln": "MSKLKVVGEKSLTNSSRVVGLLAQLEKINTDS--TESDTARHVTSKILHLAQSQEKTRREMTTKGSTGMEVLLSTLENTKDLQTVLNILSILIELVSSGGGRRASFLVAKGGSQILLQLLMNASKDSPPHEEVMVQTHSILAKIGPKDKKFGVKARVNGALNITLNLVKQHFQNYRLVLPCLQLLRVYSTNSVNSVSLGKNGVVELMFKIIGPFSKKNSGLMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMRILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPIIPVTGPVAQLYNLPPEVDDVVDESDDNDDIDLEAENEVENE-DDLDQSFKNDDIETDINKLRPQQVPGRTIEELKMYEHLFPELVDDFQDYELIA--KEPKPFVFEGKVRGPIVVPTAGEEVPGNPGNVRKGAAVKEKASPKGEE----------VKEDAKGHDKTPPWQLGGQNRAAASAHSSNNDLVKALDRITLQSTPSQVAAGLTAGMRKDYGLPLTVLSCTKACPHVAKCTSALFEGRTVHLGKLCCTGVETEDDEDFESHSSAEQVSSVEASDGPPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQNDIIDRVVYDLDNPNYTTPEEGDILKFNSKFESGNLRKVIQIRKSEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVVFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESSYYEHICQFRTRPYIFLSARVHPGETNASWVMKGTLEYLMSNSPTAQSLREAYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPNPELHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTHDNAASCDVVEDMGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGRYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYN-LPSNLLDFENDLIES--SCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELEVELAENTGDYEPSAQDEALSDSEVSRTHPI-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q641K1-1", "uniprot_id": "CBPC1_MOUSE", "id": "Q641K1-1", "name": "Cytosolic carboxypeptidase 1", "aln": "MSKLKVVGEKSLTNSSRVVGLLAQLEKINTDS--TESDTARYVTSKILHLAQSQEKTRREMTTKGSTGMEVLLSTLENTKDLQTVLNILSILIELVSSGGGRRASFLVAKGGSQILLQLLMNASKDSPPHEEVMVQTHSILAKIGPKDKKFGVKARVNGALTVTLNLVKQHFQNYRLVLPCLQLLRVYSTNSVNSVSLGKNGVVELMFKIIGPFSKKNSGLMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPIIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDLEVENELENE-DDLDQSFKNDDIETDINKLRPQQVPGRTIEELKMYEHLFPELVDDFQDYELIS--KEPKPFVFEGKARGPIVVPTAGEEVPGNSGSVKKGVVMKERASPKGEE----------AKEDPKGHDRTLPQQLGGQSRVAPSAHSFNNDLVKALDRITLQNVPSQVASGLNAGMRKDFGLPLTVLSCTKACPHVAKCGSTLFEGRTVHLGKLCCTGVETEDDEDTESHSSTEQAPSVEASDGP-TLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQNDIIDRVVYDLDNPTYTTPEEGDTLKFNSKFESGNLRKVIQIRKSEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNICPLVTITAMPESNYYEHICQFRTRPYIFLSARVHPGETNASWVMKGTLEYLMSNSPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPNPELHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTHDNSASCDIVEDMGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGRYKGLQIGTRELEEMGAKFCVGLLRLKRLTSSLEYN-LPSNLLDFENDLIES--SCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDVELAENTGDYEPSAQEEALSDSEVSRTHLI-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UPW5-1", "uniprot_id": "CBPC1_HUMAN", "id": "Q9UPW5-1", "name": "Cytosolic carboxypeptidase 1", "aln": "MSKLKVIPEKSLTNNSRIVGLLAQLEKINAEP--SESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEILLSTLENTKDLQTTLNILSILVELVSAGGGRRVSFLVTKGGSQILLQLLMNASKESPPHEDLMVQIHSILAKIGPKDKKFGVKARINGALNITLNLVKQNLQNHRLVLPCLQLLRVYSANSVNSVSLGKNGVVELMFKIIGPFSKKNSSLIKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDVEAENETENE-DDLDQNFKNDDIETDINKLKPQQEPGRTIEDLKMYEHLFPELVDDFQDYDLIS--KEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRK-VVMKENISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPSQTAPGFTAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESNSSVEQAS-VEVPDGP-TLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQSDIIDRVVYDLDNPNYTIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNYYEHICHFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNDNATSCDVVEDTGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYN-LPSSLLDFENDLIES--SCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVGDYEPSAQEEVLSDSELSRTYLP-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q4U2V3-1", "uniprot_id": "CBPC1_DANRE", "id": "Q4U2V3-1", "name": "Cytosolic carboxypeptidase 1", "aln": "MNKPKMAAEKSAS---RVLMLLSQLERLNEESRVSDNDAIRQVTGKILHLIQTQEKTRKEVGSKGSGGMEIILSSLENTRDLQTTLNILGILNELLTVGGGRRTGLFVSKGGTAILLQLLVSSSKDPPANEELMLHIHSLLVKVGPKDRKFGVKARLNGALNVTLNLAKHNLQNYKLLLPCLQVLRVYSSNSVNAVSLGKSGALEILFEIVGPFSKKSTTLLKVALDTLAALLKSGMNARRAVDRGYLPTLLAIYQDWHRNDTRHRHVIIRKSILGCIKNITNIKLGRKAFIEASGMRILYNTSTECLPVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSVFLYPLPHIPAGGPVAQLYNQPPGVDDVVDESDENEATEVDTENDTENEEDDTGHKTQNDDIETDINKLRPKQMNTRPFEELRVYEHFCREFTETFQDIDFEDSISAIPPSRVNSELHRPIIIPTT-QSSPG----LQNRRPLRESALPLKPE--------------------QSPLELDSISIAKRPDGRADADLVCSLGHLILD---AAVNGGSVDGCQDDGGE-QSVLEVPDTAALLP--------------------------------------------------LHDPELYLEMVKSTRSVPGYTEVAYPDYFGHVALNLREPILERVYGVQRTKIFQDIERLIHSSDILDKVVYDLDNQSSPLTDNGESLKFNSKFESGNLRKAIQVRKFEYDLILNSDINSNHYHQWFYFEVGNMRPGVRYRFNIINCEKSNSQFNYGMQVIMYSVQEAINGSPHWVRTGSDICYYKNHFARSSIAAGGQKGKSYFTMTFTVTFQHKDDVCYFAYHYPYTYSMLKMHLQKLSALCTP-EIYYRQEDLCETLGGNGCPLLTITAMPESSSDEHISQFRSRPVIFLSARVHPGETNSSWVMKGSLEFLMSCSPQAQSLRQSYIFKIMPMLNPDGVINGNHRCSLSGEDLNRQWQNPNAELHPTIYHAKSLLQYLRATGRTPLVFCDYHGHSRKKNVFMYGCSIKETMWQSSVNTSTCDLNEDLGYRTLPKLLSQMAPAFSLSSCSFVVERSKEATARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTSELEEMGSQFCLALLRLRRFTSPLELHNHNSHLLDMENELIDTRHIPNITSPTTYVLDEDEPAFLEEVDYSAESNDENDPELEPDLRDNH--ALPDPSSDSELSHQDSLT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*.* *: *** : *:: **:***::* :. ::.*: * **.***** *:*****:*: :*** ***::**:****:****.****.** **:: *****..::*:***: ******:.:**:.*.:*::*:: **:*.*:****:*******:****.:****.*:::**::*:*****:*****:****:*****.*.:*::*:*:******.: *:************* **********: .**:** ****:*.***:::***.** .:*.:***********:*.**:****** ***.******************************* * : ** **. *******. ** *********:*: :::.**: *** ** .:. :***********:*:* *.:*:*::***: *:.: *** :: . * .:.: : **::**: :. .* ::: ::* . * : .. . . . : *:* :*.:: *: : . * :.* . :** ..:.. :. ****:**:*:**.*:*** *:**********:. ::****** ******** ********..**:*:******* . . .::*: **************.**:** ***********************..***** ******************** :*******:*. * *:* *:*********:***:**********:*:**** * ***************** *:******.: .* :**:*:: *****.** ***:********. ***.:**.** :************:******:**:*** .* *****::*****:***************************.*..:*********.***** *. * ***:**********************:*:: *:::**: ** *******:**::****.:********:***:****************************:******** ******::**:.****:*:**.** : * ***:**:**:: ::************* ************** : ** : * . * : ****:*: ", "identical_positions": 741, "similar_positions": 256, "identity": "59.85%" }, { "cls_id": "homologset.agr.HGNC:17259", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Y4Z0-1", "uniprot_id": "LSM4_HUMAN", "id": "Q9Y4Z0-1", "name": "U6 snRNA-associated Sm-like protein LSm4", "aln": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRD----------GDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVV------AKGRG-------RGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEK------------KPGRQAGKQ-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9QXA5-1", "uniprot_id": "LSM4_MOUSE", "id": "Q9QXA5-1", "name": "U6 snRNA-associated Sm-like protein LSm4", "aln": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRD----------GDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEA-------AKGRG-------RGGPQQ-KQQKGRGMGGAGRGVFGGRGRGGIPGAGRGQPEK------------KPGRQAGKQ-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6APJ0-1", "uniprot_id": "A0A8I6APJ0_RAT", "id": "A0A8I6APJ0-1", "name": "U6 snRNA-associated Sm-like protein LSm4", "aln": "-LPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRD----------GDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEA-------AKGRG-------RGGPQQQKQQKGRGMGGAGRGRVTMRG-GRQASSEQSQPEL------------SPGRWVRRPPGAFA--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VKW8-1", "uniprot_id": "Q9VKW8_DROME", "id": "Q9VKW8-1", "name": "U6 snRNA-associated Sm-like protein LSm4", "aln": "MLPLSLLKTAQSHPMLVELKNGETYNGHLVSCDSWMNINLRDVICTSKD----------GDRFWRMPECYIRGSTIKYLRIPDEVIDMVKEDAQ------AKSRNRTEMNKNRGGNSSQNQRGGR-PGGGNRNNVGNRPGQGYGGAANNAMRLGG----------AAGQGNRLPHAAKNRK------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40070-1", "uniprot_id": "LSM4_YEAST", "id": "P40070-1", "name": "LSM complex subunit LSM4", "aln": "MLPLYLLTNAKGQQMQIELKNGEIIQGILTNVDNWMNLTLSNVTEYSEESAINSEDNAESSKAVKLNEIYIRGTFIKFIKLQDNIIDKVKQQINSNNNSNSNGPGHKRYYNNRDSNNNRGNYNRRNNNNGNSNRRPYSQNRQYNNSNSSNINNSINSINSNNQNMNNGLGGSVQHHFNSSSPQKVEF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** **..*:.: * :****** :* *.. *.***:.* :* *.: ..: :: * ****: **:::: *::** *::: ::. . *.. .. : * .... . .: . . * ", "identical_positions": 36, "similar_positions": 48, "identity": "19.25%" }, { "cls_id": "homologset.agr.HGNC:1726", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P48966-1", "uniprot_id": "MPIP2_RAT", "id": "P48966-1", "name": "M-phase inducer phosphatase 2", "aln": "MEVPPQKSAPGSALSTARVLG-GIQRPRHLSGFGFGSDG-----LLGSPERAASSSPVTTLTQTMYNLAGLG--SETPKTQVGSLSFQN--RLTDLSLSRRTSECSLSSESSESSDAGLCMDSPSPMDPQT----AERTFEQAIQAASRVIQKMQFTIKAS-VFASEAAGHSPVLQNITNSQALDSWEKDEAGYRAAS-SPGEDKENDGYIFKMPQKLPHSSSARALAEWASRREAFTQRPSSAPDLMCLT--TDGKMDVEEASPVAQ-SSSLTPVERACEEDDGFVDILESDLKDDDMVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPHDRDVPVLSKRRKSGTPLEEQQ--LEEPKARVFRSKSLCH-EIESILDS----DHRGLIGDYSKAFLLQTVDG--KHQDLKYISPETMVALLTGKFSNIVEK---FVIVDCRYPYEYEGGHIKNAVNLPLEPDAETFLLKHPITP-------CNLDKRIILIFHCEFSSERGPRMCRFIR--ERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHAAFRDELRNFRLKTRSWAG------------ERSTTQLCSRLQDQ---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P30306-1", "uniprot_id": "MPIP2_MOUSE", "id": "P30306-1", "name": "M-phase inducer phosphatase 2", "aln": "MEVPLQKSAPGSALSPARVLG-GIQRPRHLSVFEFESDG-----FLGSPEPTASSSPVTTLTQTMHNLAGLG--SEPPKAQVGSLSFQN--RLADLSLSRRTSECSLSSESSESSDAGLCMDSPSPVDPQM----AERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPVLQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVSRRQAFTQRPSSAPDLMCLT--TEWKMEVEELSPVAQ-SSSLTPVERASEEDDGFVDILESDLKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPQDRDVPVQSKRRKSVTPLEEQQ--LEEPKARVFRSKSLCH-EIENILDS----DHRGLIGDYSKAFLLQTVDG--KHQDLKYISPETMVALLTGKFSNIVEK---FVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMP-------CSLDKRIILIFHCEFSSERGPRMCRFIR--ERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAG------------ERSRRELCSRLQDQ---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P30305-1", "uniprot_id": "MPIP2_HUMAN", "id": "P30305-1", "name": "M-phase inducer phosphatase 2", "aln": "MEVPQPEPAPGSALSPAGVCG-GAQRPGHLPGLLLGSHG-----LLGSPVRAAASSPVTTLTQTMHDLAGLG--SETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHM----AEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAAS-SSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLS--PDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQE-AEEPKARVLRSKSLCHDEIENLLDS----DHRELIGDYSKAFLLQTVDG--KHQDLKYISPETMVALLTGKFSNIVDK---FVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAP-------CSLDKRVILIFHCEFSSERGPRMCRFIR--ERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAG------------ERSRRELCSRLQDQ---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B8A5N7-1", "uniprot_id": "B8A5N7_DANRE", "id": "B8A5N7-1", "name": "M-phase inducer phosphatase", "aln": "MDIDMVPGDVSPVYDPFSTGPESALGAPRFTLPELGARGSPCMKSLASPGPMAVLSPVTNLALNMNNLAVLGGQCETPK------------RKKNLPLLKIP---SFASDAS--SDAGLGLECPSPLDSLD----AEQKFEKAMQDATRAVN-EKMPIRRIHSLPLQFLGHSPNLR----SKELDPSRYGVWTHSHDS-ANKENMAEENFEFKKPSMPALRCRTRSTG---GSKDAFACRPNSAPALMLSPPPTNQPDSPNEISPFILRRPSLSCLQDD-DDDDGFLEGLD-DVENDSEVPLGMDSLLTAPLVAKQIPETDS-PVIRCRPRGLFRSPSMPCAVGRIPLKRPERPQDENTPVRVKRRRSLAGTQVSTTEQEDVVHQVQRSKSFNHSQIERMLDT----DPSNVIGDFTKAPALPTVQG--KHQELKYITPEIMVKAMSGQFQDLVER---LFVIDCRYPYEYEGGHIKGALNLHQEDQIEDYFLRSPILP-------DCPKKRVLLIFHCEFSSERGPRMCRYVR--ERDRFVNEYPNLHYPELYILKGGYKEFFQIHKAICEPQMYRPMLHEEFKEDLRKFRLKSRTWAG------------ERSKRDMYSRLKKL---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q03019-1", "uniprot_id": "TWINE_DROME", "id": "Q03019-1", "name": "Cdc25-like protein phosphatase twine", "aln": "-----------------------------------------------------------------------------------------------------MASKRLMLDVEEEDDESGACGQENFDPHDA----DMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPIT---------ELSQN----MNGARLDGTPKSTQRIPANRTLNNFNSLS----SRTLGSFSSSCSSYESGNSLDDEYMDMF-----EMES-AENHNLELPDDLEVLLSGQLKSE---SNLEEMSNKKGSLRRCLS-MYPS--------------------EQPE-----------------EAVQE-------PDQETNMPMKKMQR----------KTLSMNDAEIMRALG-----DEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTS-------NQEN---RRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRLLYAE--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P20483-1", "uniprot_id": "MPIP_DROME", "id": "P20483-1", "name": "M-phase inducer phosphatase", "aln": "---------------------------------------------------------------------------------------------------------MLWETIVEENNCSMDCNISNNTSSSS----SINKMSGSRR-ARRSLELMSMDQEELSFYDDDVVPQD---------QQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSMESSMDDEYMELF-----EMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSVRRCLS-MTESNTNSTTTPPPKTPETARDCFKRPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLR----------KCMSLNDAEIMSALARSENRNEPELIGDFSKAYALPLMEG--RHRDLKSISSETVARLLKGEFSDKVAS---YRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYRHFRAKSKSWN----GD-GLGGATGR-LKKSRSRLML----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P23748-1", "uniprot_id": "MPIP_YEAST", "id": "P23748-1", "name": "M-phase inducer phosphatase", "aln": "-----------------------------MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENENDDIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQRSSSFSRSRSLSRKPSMNSSSNSSRRVQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKCFESC---LAKTQIPYYYDDRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDH-----------YPKLFYPDILILDGG-----YKAVFDNFPELCYPRQYVG--MNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLS----------LNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVS--GDEEQDGDFTFVGSDREDLPR-------------PARRSLFPSLETEDKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: . . . : . : : . . . . :: . .: . : . : .. . : :. . . . . .: :* ::.: .: : : : :. : : : . : . :: . . : . : : ..:.*.... .:. .:. : : . .:* : . . . . . * ", "identical_positions": 4, "similar_positions": 86, "identity": "0.64%" }, { "cls_id": "homologset.agr.HGNC:17260", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5Y0F2-1", "uniprot_id": "A0A8I5Y0F2_RAT", "id": "A0A8I5Y0F2-1", "name": "Tumor necrosis factor alpha-induced protein 8", "aln": "----------MATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTKEYTQNKKEAEKVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKRKVHQLAMTVVSFHQVEYTFDRNVLSRLLNECRELLHDIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEENI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q921Z5-1", "uniprot_id": "TFIP8_MOUSE", "id": "Q921Z5-1", "name": "Tumor necrosis factor alpha-induced protein 8", "aln": "MLSEAEEPREVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTKEYTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVEYTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEENI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95379-1", "uniprot_id": "TFIP8_HUMAN", "id": "O95379-1", "name": "Tumor necrosis factor alpha-induced protein 8", "aln": "MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7KVH9-1", "uniprot_id": "TFP8L_DROME", "id": "Q7KVH9-1", "name": "Protein salivary glands marred", "aln": "----------MADNVFKSHDIGLRAQKKILSRMATKNIAKTFIDGTTASLLDNLYRLCKMHTGNKAKAEKLIKNIIKIVIKIGVLHRNNQFSDEELQKAELFKRKFQNTQLSIISFYEVDFTFDLPYLQKSIAESQVALKSIVQPHLTEKSLGRIDEVFDFFGEEALLETAFRPDSPYREVMGKIVADINAAMETGDI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :**:*:::.::******.:*.:*.**.*:**.*::.:**:***: : :* ** :**::***:** ***:.:*:*****.::** * **:*.:: ::::**::*::*** *.: : *.: *:.*:* *** ** **:::***.*.: :* : :.* . :: : *: .** :: :*", "identical_positions": 76, "similar_positions": 75, "identity": "38.38%" }, { "cls_id": "homologset.agr.HGNC:17261", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Y3A3-1", "uniprot_id": "PHOCN_HUMAN", "id": "Q9Y3A3-1", "name": "MOB-like protein phocein", "aln": "MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PEB6-1", "uniprot_id": "PHOCN_MOUSE", "id": "Q6PEB6-1", "name": "MOB-like protein phocein", "aln": "MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9QYW3-1", "uniprot_id": "PHOCN_RAT", "id": "Q9QYW3-1", "name": "MOB-like protein phocein", "aln": "MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7K0E3-1", "uniprot_id": "MOB4_DROME", "id": "Q7K0E3-1", "name": "MOB kinase activator-like 4", "aln": "MKMADGSTILRRNRPGTKSKDFCRWPDEPLEEMDSTLAVQQYIQQLIKRDPSNVELILTMPEAQDEGVWKYEHLRQFCMELNGLAVRLQKECSPSTCTQMTATDQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVTKLGSVCRRVYRIFSHAYFHHRRIFDEFEAETYLCHRFTHFVTKYNLMSKENLIVPINVG--ENAAPGESEA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* **:*:::*********::** .****.::************** *: * **:: ** **.***************:*******:**.** *.********:*************************************************:********:************:****:* **:******:** *******:****** :*:..*****", "identical_positions": 179, "similar_positions": 30, "identity": "79.56%" }, { "cls_id": "homologset.agr.HGNC:17262", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5M7T3-1", "uniprot_id": "BRMS1_RAT", "id": "Q5M7T3-1", "name": "Breast cancer metastasis-suppressor 1 homolog", "aln": "MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLLGELQERIQRLEEDRQSLDIS-SEWWDDKLHSRGSSKTWDSVPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKA------DGP---------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99N20-1", "uniprot_id": "BRMS1_MOUSE", "id": "Q99N20-1", "name": "Breast cancer metastasis-suppressor 1 homolog", "aln": "MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKMLLYDTLLGELQERIQRLEEDRQSLDIS-SEWWDDKLHSRSSSKAGDAMPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKA------DGP---------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HCU9-1", "uniprot_id": "BRMS1_HUMAN", "id": "Q9HCU9-1", "name": "Breast cancer metastasis-suppressor 1", "aln": "MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLS-SEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKS------DGP---------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VYI2-1", "uniprot_id": "Q9VYI2_DROME", "id": "Q9VYI2-1", "name": "", "aln": "MPVKNGESDGEGDVSGGESEHSNSSQPHDTSDEEEANECDSDD-SSELDASEIDRRRAEHIEDLLSLERQFNELREQYYVERINLIERQLAEVRSGRSEEFVQPQKELDKKYRTRIEVADVLRKYRLQNIEHKYQSEEQAAVQHFESEKHMALDNLREEFMERIRRLEEDRHNVDISWADWGTDKRQSK--------VRGPGRKKAVTVTGPYVVYMLREEDIMEDWTIIRKALKRSSSSATAAGTVTPTSGVSVSLSGLPAMAGASG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:: .: * : *:* . ..: .::.:*....: :*:: ***:* .: :***:* :.::*.**:**.**:*: : **:. :. :* ** : *: *:.:* *::. : **:**.: : : *: *.:**:.* *.* **:**** : *.* *: ***:******:.:*:* ::* ** ::: : . **** *:***:****:* **:**** *:** *.. : .* ", "identical_positions": 90, "similar_positions": 88, "identity": "33.58%" }, { "cls_id": "homologset.agr.HGNC:17264", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O54889-1", "uniprot_id": "RPA1_RAT", "id": "O54889-1", "name": "DNA-directed RNA polymerase I subunit RPA1", "aln": "MLASKHTPWRRLQG-ISFGMYSAEELKKLSVKSITNPRYVDSLGNPSADGLYDLALGPAD-SKEVCSTCVQDFNNCSGHLGHIDLPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAAIHLLVCQLKVLDVGALQAVYELERILS-----------RFLEET---------------SDPSAFEIQEELEEYTSKILQNNLLG----SQGAHVKNVCESRSKLVAHFWKTHMA--AKRCPHCKTGRSVVRKEHNSKLTITYPAMVHKK------------------------SGQKDAELPEGAPAAPGIDEAQMGKRGYLTPSSAQEHLFAIWKNEGFFLNYLFSGLDDIGPESSFN----PSMFFLDFIVVPPSRYRPINRLGDQMFTNGQTVNLQAVMKDAVLIRKLLAVMAQEQKLPCEMTEITIDKENDS--SGAIDRSFLSLLPGQSLTDKLYNIWIRLQSHVNIVFDSDMDKLML---EKYPGIRQILEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRTALSAVDATQREAVAKQLLTPSTGIPKPQGAKVVCRHVKNGDILLLNRQPTLHRPSIQAHRAHILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGANMTIRGCFFTREQYMELVYRGLT-----DKVGRVKLFPPAILKPFPLWTGKQVVSTLLINIIPEDYTPLNLTGKAKIGSKAWVKEKPRP-VPDFDPD--SMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGRVLTCLARLFTAYLQLYRGFTLGVEDILVKPNADVMRQRIIEESTQCGPRAVRAALNLPEAASCDEIQGKWQDAIWRKDQRDFNMIDMKFKEEVNHYSNEINKACMPFGLHRQFPENNLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIRPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVIQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFP-FLASNYEVIMKSKHLHEVLSRADPQKVLRHFRAIKKWHHRHSSALLRKGAFLSFSQKIQAAVKALNLEGK-TQNGRSPETQQMLQMWHELDEQSRRKYQKRAAPCPDPSLSVWRPDIHFASVSETFEKKIDDYSQEWAAQAEKSHNRSELSLDRLRTLLQLKWQRSLCDPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVFNTKKALRRVKSLKKQLTRVCLGEVLQKVDIQESFCMGEK--QNKFRVYELRFQFLPHAYYQQEKCLRPEDILHFMETRFFKLLMEAIKKKNSKASAFRSVNTRRATQKDLD-DTEDSGRNRREEERDEEEEGNIVDAEAEEGDADASDTKRKEKQEEEVDYESEEE----GEEEEEEDVQEEENIKGEGAHQTHEPDEEEGSGLEEE-------SSQNPPCRHSRPQGAEAMERRIQAVRESHSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHNAIVYTTKGITRCLLNETINSKNEKEFVLNTEGINLPELFKYSEVLDLRRLYSNDIHAVANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIQSSSSPLQQMTFETSFQFLKQATMMGSHDELKSPSACLVVGKVVKGGTGLFELKQPLR---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35134-1", "uniprot_id": "RPA1_MOUSE", "id": "O35134-1", "name": "DNA-directed RNA polymerase I subunit RPA1", "aln": "MLASKHTPWRRLQG-ISFGMYSAEELKKLSVKSITNPRYVDYLGNPSANGLYDLALGPAD-SKEVCATCVQDFNNCSGHLGHIDLPLTVYNPFLFDKLYLLLRGSCLSCHMLTCPRAAIYLLISQLRVLEVGALQAVYELERILS-----------RFLEET---------------GDPSAFEIQEELEEYTSKILQNNLLG----SQGTHVKNVCESRSKLVAQFWKTHMA--AKQCPHCKTGRSVVRKEHNSKLIITYPATVHKK------------------------SDQEGTELPEGVPEAPGIDKAQMGKRGYLTPSSAQEHLFAIWKNEGFFLNYLFSGLDDIGPESSFN----PSMFFLDFIVVPPSRYRPVNRLGDQMFTNGQTVNLQAVMKDAVLIRKLLALMAQEQKLPCEMTELTIDKENDS--SVAIDRSFLGLLPGPSLTDKLYNIWIRLQSHVNIVFDSEMDKLML---EKYPGIRQILEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRTALSSVDAAQREAVAKQLLTPATGAPKPQGTKVVCRHVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGANMTIRGCFFTREQYMELVYRGLT-----DKVGRVKLFPPAILKPFPLWTGKQVVSTLLINIIPEDYAPLNLSGKAKIGSKAWVKEKPRP-IPDFDPD--SMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGRVLTCLARLFTAYLQLYRGFTLGVEDILVKPNADVVRQRIIEESTQCGPQAVKAALSLPETASCDEIQGKWQDAHLSKDQRDFNMIDMKFKEEVNHYSNEINKACMPLGLHRQFPENNLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIRPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVIQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFP-FLAGNYEVIMKSKHLHEVLSRADPQKVLGHIKAIKKWHHKHSGALLRKGAFLSFSQKIQAAVKALNLKGS-IQNGRSPETQQMLQMWYDLDEESRWKYQKRAAPCPDPSLSVWRPDIYFASVSETFEKKIDDFSQEWAAQAERSYKKSELSLDRLRTLLQLKWQRSLCDPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVFDTKKALKKVKSLKKRLTRVCLGEVLQKVDIQESFCMGEK--RNKFQVYELRFQFLPHAYYQQEKCLRPEDILHFMETRFFKLLMEAIKKKKNKASAFRNVNSRRATQKDLN-DTEDSGRSQREEERDEEEEGNIVDAEAEEGDADASDTKRKEKQEEEVDYESEEE----GEEEEEEEVQEEGNIKGDGVHQGHEPDEEEHLGLEEEE------SSQKPPRRHSRPQGAEAIKRRIQAVRESYSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHKAIVYTTKGITRCLLNETTNSKNEKELVLNTEGINLPELFKYSEILDLRRLYSNDIHAMANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIQSSSSPLQQMTFETSFQFLKQATMMGSHDELKSPSACLVVGKVVKGGTGLFELKQPLR---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O95602-1", "uniprot_id": "RPA1_HUMAN", "id": "O95602-1", "name": "DNA-directed RNA polymerase I subunit RPA1", "aln": "MLISKNMPWRRLQG-ISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPAD-SKEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLLLCQLRVLEVGALQAVYELERILN-----------RFLEEN---------------PDPSASEIREELEQYTTEIVQNNLLG----SQGAHVKNVCESKSKLIALFWKAHMN--AKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRT------------------------AGQKDSEP-------LGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFN----PSVFFLDFLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTTDEEKDS--LIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMM---DKYPGIRQILEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCRHVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRGLT-----DKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKETPRS-VPGFNPD--SMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFP-FLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRRGAFLSYSQKIQEAVKALKLESE-NRNGRSPGTQEMLRMWYELDEESRRKYQKKAAACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKWQRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEK--QNKFQVYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLD-NAGELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEENDDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B7B0-1", "uniprot_id": "A0ACD6B7B0_DANRE", "id": "A0ACD6B7B0-1", "name": "DNA-directed RNA polymerase subunit", "aln": "MQFSKETPWRRLEG-MSFGLFSADETRKLSVKTITNPQLLDNVGNAAANGLYDLALGPAD-NKEICSTCMQDFSSCPGHFGHIELPLPVYNPLFFDKLYLLIRGSCLSCHILKCPRAAIHLLLCQLKLLDVGAMKEVFEIENVLN-----------QFLESN---------------PSPPGEEIQETLNDFVKPILETRKDK----QHTDPVKHICEKKSSLITSFWRIHMG--PKKCQNCKANRMTVRKEHNSKLIVT--QTLHKK------------------------ASEQD-------------DDSQLTKRIFLTPSVAREHIIKLWETEGFFLKHLFSGFDMDNSDNGFN----PEVFFLELLVVPPCRYRPINRLGDQMFTNGQTVNMQAVLKDGLIIQKLLTLIADEKTKAIEGTQTELEQSSEAPKVTEIDQSFLTSIQGVTLTDKLYSTWIHLQSLVNIVFDSDMDKLIT---EKFPGVRQLLEKKEGLFRKHMMGKRVDYAARSVICPDMYIGTNEIGIPMVFATKLTYPQPVTPWNVKEMRQAVLNGPNIHPGATMVVNEDGSRTILSSTNQTQREAVAKQLLTPSTGQHRIP-MKIVNRHIKNGDVLLLNRQPTLHRPSIQAHCARILPGEKVLRLHYANCKAYNADFDGDEMNAHFPQSELSRAEAYTLVSTDQQYLVPKDGKPLAGLIQDHMVSGTSMTIRGCFFTRDQYTALVYRGLT-----DKIGRVKLLPPTLIKPVLLWTGKQVVSTLLLNVIPENSIPLNLTGKAKIPGKAWVKESPRP-VPGYVPE--SMCESQVVIRQGELLMGVLDKAHYGSSAYGLVHCCYELYGGETSGKLLSCLARLFTAYLQLYRGFTLGVEDILVKDGANKQRKKIIKKSVTCGSKALQAAFNLPASAEDTEARERWQDAHLNIDQRDFNMVDLKFKEEVNQVNNNINKVCMPLGLHRSFPENNLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMPSGKSLPCFQPYEPQPRSGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCVIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPRQFP-FIKDNYEVIRKSKCLDEVLAKMDPVAALNHFKAIKKWKAKHEHASPRDGAFLLFSQKKMSKLKAQVEGHE-LVNGREEATLQLIERWRALDESGRMRYSKKTSHCPEPCLGLYRPDISFGSVSETFDSIVESYLNQFNIKQEFSASSETTDADRLRNLLQLKWQRALCDPGEAVGLVAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILLVASSNIKTPMMSIPVVMNKKALKQVKTLRKKITRVCLSEVLHKVNVIESFRMPKKE-TLKSRVFKITFHFLPPERYQQDKLLNPDEILHYMEQTFFRMLLEAIKKLTAKLAAISLVETRRATVNDNDRDTSDGGADREDNGGEDAENERIVDDEANEGDADATDSKRKEKQEEEVDYESEEGEE--GSDQEQEEVAEDQE-------ASQEVSEEGS-------------TESQQRVNSEQPKGSSQGSVRINSVLQLSAAIEDYKYDTKKGLWCELTLVMPITKVHFDLTSVVVKQAQNAVIMETKGITRCLLNEVTRKDGSKEMMLNTEGINIHEMFKYADILDLKRLYSNEVHAMASTYGIEVALRVIEKEIKDVFAVYGIEVDPRHLSLVADYMCFEGVYKPLNRFGIQSNSSPLQQMTFETSFKFLKQATMLGSYDKLSSPSACLVVGKVVKGGTGIFDLKQPLQ---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P91875-1", "uniprot_id": "RPA1_DROME", "id": "P91875-1", "name": "DNA-directed RNA polymerase I subunit A", "aln": "MGSKRAMDVHMFPSDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTCLK-LQDCPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAGYIIEAQELELFKS-----------EIVCQN---------------TEN-LVAIKNGDMVHPHIAAMYKLLE----KNEKNSSNSTKTSCSLRTAITHSALQRLGKKCRHCNKSMRFVRYMHRRLVFYVTLADIKER------------------------VGTGAETG---------------GQNKVIFADECRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQT-----------------LKGETAHEKLYTAWLALQMSVDVLLDVNMSREMK---SGE-GLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAKLLLSNPK-----DGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQLVFQGLS-----QLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTLLLTAFTKVFTFFLQLEG-FTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPPHDELVEKMEAAYVK-DSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPAKLR--AAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCPDPTVAVYKQDLYYGSVSERTRKLITDYAKRKPALKET-----------IADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIKPGQQ--HQAEKLRINLNSVTLANLLEYVHVSTGLTLDPE----RSYEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQTFFKQLIRAILKVSNASRTTKIVVIDDKKDADKD---DDNDLDNGDEVGRSKAKANDDDSSDDNDDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDED------------DEEKG-------------------QDGNDNDGDDKAVERLLSN----DMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKRAIIYK----GNDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGMEHSSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVRNGTGAFELLTKIC---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P10964-1", "uniprot_id": "RPA1_YEAST", "id": "P10964-1", "name": "DNA-directed RNA polymerase I subunit RPA190", "aln": "MDISKPVGS-EITS-VDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFL--RNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNELKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLS--RGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDVGRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKA-----DSFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQK-----DKVSLED-------------------RRVIFSRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGK---------------GSLENEVLFKDGALLCGILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATA-FTCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFC---LDNYYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHS----------------------------------------------------KEPHYKQSVKY-DPVLAKYNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNE---KKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSD-EQADTFCKSISKVLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQAVSYDEPDEDEIETMREAEKSSDEEGID-----SDKESDSDSEDED---------VDMNEQIN-----------------KSIVEANNNMNKVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQIPHIDRCVHPE----PENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* .: : . :.*.: : .* ::**. : . .* :*:. ..****: :*. : *.** . *.** ***:* . ***:::. : : ** *: : :*:::: * : ::: . . : .. . ::. . .. . .* : : : :* :* .* : . : . : . :. : :: . .*: :. . . . **:: : *.* * * . :*: : * *. :: ::. : : : : .:* . :: :* *: .:* : *::* :***.**:*.*******:****:** ** * .:***:* :** **:** *** :*: *:*: *:***: ***. : :::* . : . . :*:::*: **: .. * * **: * *::*:****:**:.*: .* .::* **.:****:* ************ *:**.* .**** *. . .:**.*..* *: ******: :*. :: :. **.*:.* :: : : :.*:::** **:***:::*:::*: * . :** . ** .: * . *.:* :::* ** *:*** :**:: **::*. :*:** :.: :*: : ::** :: ** *:.*: :. .: * *:. . * * . .* . : . *.. ::* .. :: ..:: . *:* * .** *.:* *. ****** **. ** ***** ***:* *:* ***:**.* .:* . :**:: *** :**:* :::**********:***************: *:***: : ** ::**:*.::***:** *.:** * ..: * .: : : . : . : : .:. :: : : *: :* :. :. .**** : .: .. : : ::::* ::* ***.**::*:**:****************:* ************:: **: **** * :*: . .:...: :. * *.:::. : : : : ::*: *.:: : ..: . : *:: * :* * . . .. : . : . . . * . . :: :: . :. . ::.:. *: : .*: . . * : : * :* :. **:..: :. : : .:: . . ::: * *.: : . . :* *:*:*: ::. .:*: : **:: *: ***:*.* ..* :*:.:** *.* *. ***.*:** * :*.: .:.* *:. .:*.: :*::*:: :**..*. . ::* ***: ::** . *** *:: : ", "identical_positions": 412, "similar_positions": 493, "identity": "22.76%" }, { "cls_id": "homologset.agr.HGNC:17265", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7Z7G0-1", "uniprot_id": "TARSH_HUMAN", "id": "Q7Z7G0-1", "name": "Target of Nesh-SH3", "aln": "----MLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWIFQICPATETIVENLKPNTVYEFGVKDNVEG--GIWSKIFNHKTVVGSK-KVNGKIQSTYDQDHTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLPASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSET-------------------------------------------------TLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTTSAG-TITPKISKSP-------------------------------------------------------------------------------------------------------------EPTWTTPAPGKTQFIS---LKPKIPLSPEVTHTKPAP-----------------------KQTPRAPPKPKTS---------------------------------------------------------PRPR----------------------------------------------------------------------------IPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQS-----------EP-----APLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTT-VRPRTSDKPHIR-------------------------PGVKQAPRPSGADRNVSVDSTHPTKK---PGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQ-KPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6AGS4-1", "uniprot_id": "A0A8I6AGS4_RAT", "id": "A0A8I6AGS4-1", "name": "", "aln": "----MLSSLGCLLLCGSIALALGNAQKLPKGKKPSLKVHINTTSDSVLLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVVDAEPKYLIVVRPAPPPSQKKSCSGKSRTRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCSSDRFYTIRYREKDKEKKWIFQLCPATETIVENLKPNTVYEFGVKDNIEG--GIWSKIFNHKTIVGSKNKVNGKIQSTYDQVHSVPAYVPRKLIPITIIKQVIQNVTHRASTKSPDKIPFGGTILVHLIIPGLNDSTVKLPSSIMLEISDALKAQLAKNETLALPAESKTPEVEKVAGQPVTVTPETVSRSTKPTLASALDTAETALVLSEKTPETAQSVLIPESELLLSSLAPKGSPEFPEAKTAFPSEKPGGSLASSEEPWVVPGAKTSEDSRVVQPRTATYDVVSSSATSDETEVEP-HTATSDPILDSVPPKTSRTAEQPRATLAPSEASFDPRTVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQSTKAPPHKTKKPGRRRPKTTRSPEVPKSKPALEPATVPPEILVPTIVPKPPQRPKATRRPEAPQIQPAHEPVTFGSEAPALAIVTTTDIAPVISRTKASVTTLAPKSSRPRTRQRPKYKATPSPKIPQTKPDLGPITAEPSLASTTKKVRRPRPKPKTTPHPEVPQTILVPATSLEPVIRTETPGTTLVPKLSQQPDFPHPKPKTTRSPAAPPTELVSTTVFEPVIPLKEDPVTTIVPFTDLEPATDLETPVAFRTEAPRTTLASKKSQRTRRPRPRPPKATLSPQAPKTKTVPAVVLEPVTLRPEVQVTTLAPKKTQIKHRPRPKPKPIPSPEVAESKPVPTKEREPVTLRTESWVTTKAPKTPKRTHRVRPKPKTTTPEAPLTKPVAATDLESSALSTEVPTTVVLTTALVPATLRTKSPKTTLAPSVQRTRRPRPRPKTTARTDVSESKSAPTELQTRVLKPMTSSSLEITQSQSVSDDLELVAFSTESPQKTIAPRQTTSPPPKLKPPHSRRPAKEQVPKGSLHTTSKPKMPPSPEVVDITSVPKDEQLSHKPDPEVSQSETVLPPVTFRVEPPKTTIVPLETRDIPLIPVISPRPSEEELQTTMEQTDQSTQELFTTKIPRTTELAKTTQAPHRLHTTPVRPRIPERPHGRPALNKTTTRPDRTKSRGMSHKNGVGPGTKQTPKPSSTGRNTSVDSHATRKPGLIPGTRHRHTSPRPVPPQRKPLPPNNVTGKPGSAGIISSSRATSPPLKATLKPTGTATERPGAEKKQPTAPASEEEFGNTTDFSSSPTKETDPLGKPRFIGPHVRYIP-KPDNKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0AC58IDH4-1", "uniprot_id": "A0AC58IDH4_DANRE", "id": "A0AC58IDH4-1", "name": "", "aln": "MAGSTVLHLGFLLTLAGILLFACSSAQRVRVRRQNMKVRINATGDTIVLKFVRPNPDVKLEGYILGYGSSMFSKQFIQLPENGEPYETEIDAEPKYLVAVQPMPTNDVKKHCTGKVNLEKPLHLVIDSVTPTSVLLSWGTYLKTPYEGNIMNDCLEEGHYTIRYRERNR--KWIYQTCSTSDTVIDNLKPNTPYEFGVRPNKDDRSGMWSKPVIHNTNMGDK-----IMQINYKHNRPIAKPLGGPHSPFP-LRPVPNNISHPVPSKNTG------------IFGGP---------------KTSFAPPMGQQGTVAAPRANEP----KWPQLPLDTDSHVRNDSSQ----------------------------------------------------------------LVEIPRILP--------------------------------------------QLLPTKPFRSSASP-------------------TPQSLTSSTRAPLHGHPQNKAPSATQMPHG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSGKNIRGDISSLP---------------------------------------------------------------------------------------------------------------------------------------------SKPAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLTVTTRN------------------------------------------------------------------------QTSLGRNPFSFSNGMRHSPPRLGDPSRRHGANGEHHKGLSFPKPALWSRAR--------------------------MGSSAGRPNNALKNPNVVGMHERIG----KDMKPDVNQDKASILMPKLPP--VTAKPSKPKTTSAPSVTAP---------------------------KYETWENSSSFSPVPASKVDAMGKERYIAPHVVYKTDKKPDEPCSITTSLTYFPEEEGGEQNVTNPPKTAPSNLTVVTVEGCPSFIILDWEKTDNET-TEYEVISTTKG-PDGEQVSILTTNQTHTAVENLKPESSYEFKVKPKNELGEGPSSEPVSFSTESADPRVSENVS-GKDAIWTQFPFKTDSYSECNGKQYVKRTWYRKFVGVQLCNSLRYKIYLSDSLNGKFHNIGDQTGFGEDHCQFVDSFLDGRTGTQLPADQLPSRPGFYRAMRQEPVHFGQIGGNSHVNYVAWYECGTPIPGKW", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 355, "similar_positions": 244, "identity": "21.81%" }, { "cls_id": "homologset.agr.HGNC:17267", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VDP8-1", "uniprot_id": "Q9VDP8_DROME", "id": "Q9VDP8-1", "name": "", "aln": "---------MSEEAASTSSFGFKKRNLKKGAGIRRKKETSSDESAKSSDEETKGKASALVRAENRRKRTNPNFQSTKTMSKAKRQAGGVGDDGSSSASDDDKLGIAYKSKREALPSGPQDQGATSINEMDTELDRDAQAIHARALKINEELEGKADDKIYRGINNYAQYYKKQDTAAGNASSGMVRSGPIRAPAHLRATVRWDYQPDICKDYKETGYCGFGDSCKFLHDRSDYKAGWQLEMDHENQRTGDVDSDGDDTKYEIHSDEETLPFKCHICRQSFVNPVVTKCKHYFCEKCALAQYKKSQRCIICSQQTNGIFNPAKELIARLKTNPMENSDSDEEEEFGKKEDKAEAGEEAQEISSDDSD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IZP6-1", "uniprot_id": "R113B_HUMAN", "id": "Q8IZP6-1", "name": "RING finger protein 113B", "aln": "MAAPPSPGRTADQADQVCTFLFKKPGRKGAAGLRKRPACDPEHGESSSSGDEGDTVAQPPRVAPRPR----GLHSWQKAAHGDRRG---------EEAAPESLDVVYRSTRSAKPVGPEDMGATADFEQDTEKEHHTPTILKCSQRVQEALRGREHDHIYRGIHSYLRYLKPKDTSMGNSSSGMARKGPIRAPGHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKLGWEIERELEEGRYCICE----DENHEVGSEEEEIPFRCFICRQAFQNPVVTKCRHYFCESCALEHFRATPRCYICDQPTGGIFNPAKELMAKLQK--LQAAE-------GKKR------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P53769-1", "uniprot_id": "CWC24_YEAST", "id": "P53769-1", "name": "Pre-mRNA-splicing factor CWC24", "aln": "---------------MFRKRLVNKSSSDEKNQKKRQKINFSEEKLVASDEEKGSSDLMSLAKSGNSR----------------------------------TLQLSHENEGKLQKKG-EDLDKYTLTVNDDSTKEDLLNFERKELAEKAKKRRPSDD---------------NELVLNMSGKNKRLTKQINQPTNIRTTVLMDFQPDVCKDYKQTGYCGYGDSCKFLHSRDDFKTGWKLNQEWNADK---------EDSKAVTLDLEKIPFKCTLCKEDYKSPVVTNCGHYFCGSCFAKDMKKGTKCFICHKETHGSAKVASDLQKMLNK---------------RKS------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .:* . . ::: .:. :*. : .. . : .* : :.. . * :* . : * . ... : : . .* :: . :... . *. * ::*:** *:***:*****:**:**:********.*.*:* **::: : : : : . : : * :**:* :*:: : .****:* **** .* . : :* ** : * * : *.:* *:. :* ", "identical_positions": 62, "similar_positions": 84, "identity": "16.94%" }, { "cls_id": "homologset.agr.HGNC:17268", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QYM8-1", "uniprot_id": "CENPH_MOUSE", "id": "Q9QYM8-1", "name": "Centromere protein H", "aln": "MEEQPRERSEAG-AEACEE--KRGLSQAAEER---IEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVALRDNMENMGPENCVLTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTEIKITTVVQHTFQGLILASKTNWAEDPALRETVLQLEKDLNTL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M389-1", "uniprot_id": "F1M389_RAT", "id": "F1M389-1", "name": "", "aln": "-MEPLRERPVAG-AEACGE--ERGP-QASEER---IMDRISLLLRLRAQTKQQLLEYKSVIDANEEKTPEQIMQEKQIEVKIEDLENEIEDVKSNFEVKSLALSRMKLSAALQNNLENMGPESSLLTDDMKHVMQLQKLIMKSQEESKELEKKLLDVRKKRLQLKQASRSKLLEIQTERNKQKEDVDKMENSEVVKAMKDKLQLEIKITTVIQHAFQGLILGSKTNWAEDPTLRELVLQLEKNLTTL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H3R5-1", "uniprot_id": "CENPH_HUMAN", "id": "Q9H3R5-1", "name": "Centromere protein H", "aln": "MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSMVDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKISRQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLEKNVDMM", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : *:: * * *.: : **::******************::*:.***************.***:******:** :*:*.***.**:**.**:.*:*::. :..:* *:***:::*:*******:** :**:****:***********.******* *:**** *:*.***** :* ::.:** *******:**.**.***.**.******:*:* ******:: :", "identical_positions": 149, "similar_positions": 60, "identity": "60.32%" }, { "cls_id": "homologset.agr.HGNC:17269", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4AEE6-1", "uniprot_id": "D4AEE6_RAT", "id": "D4AEE6-1", "name": "Kinase", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVRHGSDKGKAGVGVPLEPFLHQVGGHLSVLRYDAYTVCKPLIFQEQKFYESLPL---AMRRFTPQYKGTITVHLRRDSRG-------------------------------HLGLVANPL---KENLEPFQVSPESRAVALWQTLQQTTS---------SEGSPC-----PLAQMAHSLKE-------------------------------------------------------------------------------------------------SAA----------------KALLRSDCHLSTQASP----------------------------------------------LVESAVGSQIERKGFNP----------------------------WGLHCHQAHLSR------------------LCSQYPEDKRHRFLLLENVVSQYKQPCILDLKMGTRQHGDDASEEKKARHMKKCAQSTSACLGVRICGMQVYQTDKKSFLCKDKYYGRKLSV-EGFRQALSQFLHDGIRLR--TELLEPILRRLQALLTVIRSQSSYRFYSSSLLIIYDG-EPPQTAPAPQTTQGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSG-STSGDPAKVDVRMIDFAHTTYKG------------------SWNERTTYEGPDP-------GYIFGLENLIGILRDIQEGE--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BWD2-1", "uniprot_id": "IP6K3_MOUSE", "id": "Q8BWD2-1", "name": "Inositol hexakisphosphate kinase 3", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVRHSSDKGKIGVGVPLEPFLHQVGGHLSVLQYDAYTVCKPLVSQEQKFYESLPL---AMKCFTPKYKGTITVRLRRDSRG-------------------------------HLGLVANPL---KENLEPFQVSPESRAVALWQTLQQTTG---------SESSPC-----PLTQLARSLKE-------------------------------------------------------------------------------------------------SAA----------------KVLLRSDCHLSTQASP----------------------------------------------LVESEDGSQVERKGFNP----------------------------WGLHCHQAHLTR------------------LCSQYPEDKRHRFLLLENVVSQYKQPCILDLKMGTRQHGDDASEEKKARHMKKCAQSTSACLGVRICGMQVYQTDQKSFLCKDKYYGRKLSV-EGFRQALSQFLHDGTRLR--AELLEPILRRLQALLTVIRSQSSYRFYSSSVLIIYDG-EPP------QTTQGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSGGVTSGDPAKVDVRMIDFAHTTFKG------------------SWNEHTTYEGPDP-------GYIFGLENLIGILRDIQEGE--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96PC2-1", "uniprot_id": "IP6K3_HUMAN", "id": "Q96PC2-1", "name": "Inositol hexakisphosphate kinase 3", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVQNSADAGDMRAGVQLEPFLHQVGGHMSVMKYDEHTVCKPLVSREQRFYESLPL---AMKRFTPQYKGTVTVHLWKDSTG-------------------------------HLSLVANPV---KESQEPFKVSTESAAVAIWQTLQQTTG---------SNGSDCTLAQWPHAQLARSPKE-------------------------------------------------------------------------------------------------SPA----------------KALLRSEPHLNTPAFS----------------------------------------------LVEDTNGNQVERKSFNP----------------------------WGLQCHQAHLTR------------------LCSEYPENKRHRFLLLENVVSQYTHPCVLDLKMGTRQHGDDASEEKKARHMRKCAQSTSACLGVRICGMQVYQTDKKYFLCKDKYYGRKLSV-EGFRQALYQFLHNGSHLR--RELLEPILHQLRALLSVIRSQSSYRFYSSSLLVIYDGQEPPERAPGSPHPHEAP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAAHGSSPGGLTKVDIRMIDFAHTTYKG------------------YWNEHTTYDGPDP-------GYIFGLENLIRILQDIQEGE--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W2E9-1", "uniprot_id": "Q9W2E9_DROME", "id": "Q9W2E9-1", "name": "Kinase", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVYFLGDWGMGDSDLSSYQQHVPNIQQPRRIHGHDLLLQQQQQQLPQQQQQQQQQQQQQQQE---FVAQISSSLSQVQAQLQFASGSS-------------------------------FLQQGSSPS---PSQQQHGPVSSSSLVTANLQQLSVSSSNASSSSSNNNSASGCNTPTKPQKQKPLLLPE-------------------------------------------------------------------------------------------------AAASTATAVGKSSKNPQLSKDLLDNEDEVALHPLSNQVGGHTRLLLLNQSTVIKPLNLRELDFYQNIPQDILKFVPKYKGVMQATTMGGAKLDKRYSPSFRDDAAAVPVRKMSASKRKRDEVLRMKVHKNGQAAEVIK------------------SISQLDNTNKQYFLMLENITSQFRNPCILDLKMGTRQHGDDASAEKRSKQMAKCAASTSGSLGVRLCGMQTYLADLEQYAKRDKYWGRELNE-GGFKTALHDFFHNGYRLR--IRVIRKILQRLLQLRRVIEKQSSYRFYSCSLLIVYEGFEENPMAPPPSMSQDEWPEAPRSATVPGTVFDYHPENSIDEDDLEDDDEAGNEAGDELEAHDTDDDLHLVAADSGNASATNSSTGGDACNYDADASNDSNSLLNLATRRHLHKRGFAEAAARGVKQTASHNTTTDEEEEDEHPAMPPPRTCGVMAAKAAAAAAGLAGKGQGAFIPISEETVFLDPEPALPSVTTSSPHSGDSWMNYSSNSSDDFSGLSEQIKAVASGRQTCNNSSDDASSDYESSIIGPTEAMFKRYKSQQSFDAATAADSASSPPLTAGNSSVSNGGTTVRSLVSPASSSASSLKSVKGAVKRLRCNDDDQQSASLGESDLREAKKSTITSTPVSAVSSPAKAAPQLRSCESISNQQSLLSGLLLDNNNEQRRNALLQQSSKSLDMSAPPTDDNQCFVDVRLIDFAHTAFVPRNGTML-----------PTPAAAPVHHGPDG-------GFLTGLDSLNRLLNEIVAEERA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12494-1", "uniprot_id": "KCS1_YEAST", "id": "Q12494-1", "name": "Inositol hexakisphosphate kinase 1", "aln": "MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKD--YYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD--", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . * .:: ** ::: . : : :::: :. : : . . .. . : :.* . :. .* . : . : .. . . : * :.: : * : : . .* . : : .: . *::**::. : :** *********:* **. *: : ** :** ****:**::.: * : :***:**.:. * .* *:::* :. . : ::::* * * . ..**:*..*:*::*:* .: . *: : .:: :..*: : :: : : ", "identical_positions": 58, "similar_positions": 117, "identity": "4.21%" }, { "cls_id": "homologset.agr.HGNC:1727", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P48967-1", "uniprot_id": "MPIP3_MOUSE", "id": "P48967-1", "name": "M-phase inducer phosphatase 3", "aln": "------------MSTGPIPPASEEGSFVSAPSFRSKQRKILHLLLERNTSFTIRSDFPESPKDK-LHDSANLSILSG-GTPKCCLDLSN--LSSGEMSASPLTTSADLEDNGSLDSSGPLDRQLTGKDFHQDLMKGIPVQLLCSTPNAMNHGHRKKIAKRSTSAHKEN-----INTSLKALEWEAPRTPRFRKMP--GGPLTSPLC-ELE--------MKHLGSPITTVPKLSQNVK---LEDQERISEDPMECSLGD-------QDAKGLSLRKMVPLCDMNAIQMEE--EESGSELLIGDFS--------------------KVCVLPTVPGKHPDLKYISPDTVAALLSG-KFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFFLRKPVVPLDIQ-------KRVIIVFLCEFSSERGPRMCRSLR--EKDRALNQYPALYYPELYILKGGYRDFFPEYMELCDPQSYCPMLHQD----HQAELLSWRSQSK------------------------AQEGERQLQGQIALLVKGASPQ-----------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LL59-1", "uniprot_id": "A0ABK0LL59_RAT", "id": "A0ABK0LL59-1", "name": "M-phase inducer phosphatase", "aln": "------------MSTVPFPAASEEGSYVSAPSFRFKQRKMLHLLLERHASFTVGSDFPESPGDK-LHDSANLSLLSG-GTPKCCLDLSS--LSNGEVSASHLSTSADIEENGSLDSSGPQDIHLTGKDFHQDLMKGIPAQLLCSTPNALDHGHRRKDAKCSTSANKEN-----INTSFKTLEWEAPRTPRLQKKP--GDPLASPLC-ELENGILLESEMKNLGSPITTVPKLSKNLK---LEDQEGISEDPMECSLED-------QDAKGLSLKKTVPLCGMDAIELEE--EDSDSEHLTGDFSKIVFRNSGSFCINRPAARIVEACVLPTVPGKHQDLKYISPDTVAALLSG-KFQSVIERFYIIDCRYPYEYLGGHILGALNLYSQKELYEFFLKKPVVPEDTQ-------KRVIIVFLCEFSSERGPRMCRSLR--EKDRALNQYPALYYPELYILRGGYRDFFPEYMELCEPQGYCPMLHQD----HQAELLSWRSQSK------------------------AQEGERQLREQIALLVKNVSPQ-----------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P30307-1", "uniprot_id": "MPIP3_HUMAN", "id": "P30307-1", "name": "M-phase inducer phosphatase 3", "aln": "------------MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSG-GTPKRCLDLSN--LSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLE--EDSNQGHLIGDFS--------------------KVCALPTVSGKHQDLKYVNPETVAALLSG-KFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQ-------KRIIIVFHCEFSSERGPRMCRCLR--EEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQD----HKTELLRCRSQSK------------------------VQEGERQLREQIALLVKDMSP------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P20483-1", "uniprot_id": "MPIP_DROME", "id": "P20483-1", "name": "M-phase inducer phosphatase", "aln": "MLWETIVEENNCSMDCNISNNTSSSSSINKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSMESSMDDEYMELFEMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAG-----LSMRRPSVRRCLSMTESNTNSTTTPPPKTPETARDCFK-------RPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTIS----------HPPPLRKCMSLNDAEIMSALARSENRNEPELIGDFS--------------------KAYALPLMEGRHRDLKSISSETVARLLKG-EFSDKVASYRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPA----YNEAYRHFRAKSK------------------------SWNGDG-LGGATGRLKKSRSRLML---------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P23748-1", "uniprot_id": "MPIP_YEAST", "id": "P23748-1", "name": "M-phase inducer phosphatase", "aln": "-------------MNNIFHGTEDECANEDVLSFQK-----ISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINK-----ENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENENDDIVLSMHFAS-QTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGS----------PQRSSSFSRSRSLSRKPSMNSSSNSSRR---------------VQRQDGKIPRSSRKSS----QKFSNITQNTLNFTSAS---------------SSPLAPNSVGVKCFESCLAKTQIPYYYDDRN------------------------------SNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNN----TLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .. : . * : * . .. : : . .::. . . : .: .: . .. : . . . * .. . . . . . . * ... :. . ..: . . :. . . .* . : : :..:*: :*.. .. :****: **: **** .: *::: .:: *: : :::: *****.*** :. ** :. : ** *.**:: :* .**: .* .. *** *: * * : * :** :.. : : . ", "identical_positions": 47, "similar_positions": 108, "identity": "7.16%" }, { "cls_id": "homologset.agr.HGNC:17270", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8CEE6-1", "uniprot_id": "PASK_MOUSE", "id": "Q8CEE6-1", "name": "PAS domain-containing serine/threonine-protein kinase", "aln": "-----------------MEDRGPPVFAEDWKCLSESPP---VQEGPAAQATFEPSKPLSIAHKHLSRKNG------------------------LSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCSGS-LLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTV---------------------VDIVSRIGEKIPVSVWIKR------------------------------------------LQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLLPDGTIYGVNHSFALMLFGYGKTELLG-KNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGEMNSDAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQ-VSSRTQTRLETGYKILPSSACQPSLGVDSNPEDGEQSLLTDQQSIPKRNLPAHGG----QNQLDTSEISLPVLKEHLLSEIQKNISEESPLTHRKWLS-KVQQNPTKGSLPIHEEQLLFAGQHIHVLGKEDPSAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVDTCNLHQEAQLELMGVSSP---NPWADATMPEPHTTGQIAGGS-LTYCPQYRSEWASQQRGQDSAPSPSGMACVLLGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDLGGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHCSCTTSELSEAPSLSVVGSDLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPDPGPNDMCLSAEKPRPSAQITSTP--VARGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQGSATLFCCWLVKDLFHSHR-----DSATRTRLFLASLPSSTHS-MPELSGSSFGEVLRAKPWFEESPTPAELEGLAACEGEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILS---KVDHANIIKVLDIFENQEFFQLVMEKHGSG--MDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHP--PFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQPESGLLSAASLEIGSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LLF4-1", "uniprot_id": "A0ABK0LLF4_RAT", "id": "A0ABK0LLF4-1", "name": "PAS domain-containing serine/threonine-protein kinase", "aln": "-----------------MEDRGPPVLAEDWK--SESLP---AQEGPATQAFVEPSKPLSIAHRHLNRKNG------------------------LSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAATPDYADPIAGPLGSTSCCSLLRGLASGCSGP-LLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLTQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVAPASHSRMILSSWSTDSPILSVDIVSRSGEKIPVSVWIKR------------------------------------------LQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSIQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKSKTSGKAVAESEVASEPGYQASVWVFCTISGLITLLPDGTIYGINHSFALMLFGYGKTELLG-KNITCLIPGFYHCMDLAYDSSVQLPDLVNCLDIGSKSGPGEMSSDAKQDWELASGAQDPRID-VLTRGHMPSQDETLKLRGGQ-VSPRTQTQLETGRHILPSCASQPSLGVDSSPVDGERSLPTDQRNVPKRNLLAHAEQLLSQTQPDTLEISPPVLKE--LSEIQKNISEESPLTHRKWLLSKAQKDTTKGSLPIHDEKLLLASQHIHVLGKENPSAAESYREGLLAESRSKPVDAKPFASCEDSELLVPAKDRSNRADMSSLQQEAQLELMGISSPGSPNPWADATMPEPHTTGQIPGGS-LTYCPQHRSEWILQQRGQDSAPSPSAMGCVFVGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSFGGALGISCVELVPAEHPPFTAPVSFCDWGGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVSSYSWNLRELFLNDRTDRTPSHCSCTTSELSETPSLSGVGSDLDVGILHRQTSDILAHREMLLLSGTYFDLREGHRFQEMGAGHDGAELSNISLVSSEHYETSDIESLGCDPPIPDPGPNNMCLSAEKPRLSAQITSTP--VAPGPTSLQQEIQEGIFSGSCYHRDGLRLSVQFEVKRVQLQGSATLFCCWLVKDFLHSHR-----DSATRTRLFLASLPSSTHS-MPDLSGSSFGEMLRAKPWFEESPTPAELEGLAACEGEYSHKYNTLRPLGSGAFGFVWTAVEKEGNKEVVVKFIKKEKVLEDCWVEDPKLGRVPLEISILS---KVEHANIIKIVDVFENQGFFQLVMEKHGSG--LDLFAFIDRHPCLDEPLASYIFRQLVSAVRYLRSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHP--PFLVSQELMSLLSGLLQPCPEQRTTLEKLIVDPWVTQPVNLDNYTWEEVCRTSQPESGLMSAASLELASRSPSEVAQTEGLCRPPAPKEAPGN-HCLHLEDPSSPVS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96RG2-1", "uniprot_id": "PASK_HUMAN", "id": "Q96RG2-1", "name": "PAS domain-containing serine/threonine-protein kinase", "aln": "-----------------MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNG------------------------LSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSE-PRGSVSCCSLLRGLSSGWSSP-LLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTV---------------------VDIISRSGEKIPVSVWMKR------------------------------------------MRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLG-KNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPE---------------------------------------------------------------------------GSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQR-----DSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS---RVEHANIIKVLDIFENQGFFQLVMEKHGSG--LDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHP--PYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P31374-1", "uniprot_id": "PSK1_YEAST", "id": "P31374-1", "name": "Serine/threonine-protein kinase PSK1", "aln": "MPYIGASNLSEHSFVNLKEKHAITHKGTSSSVASLQTPPSPDQENHIDNELENYDTSLSDVSTPNKKEGDEFEQSLRDTFASFRKTKPPPPLDFEQPRLPSTASSSVDSTVSSPLTDEDIKELEFLPNESTHSYSYN-PLSPNSLAVRLRILKRSLEIIIQNPSMLLEPTPDDLPPLKEFAGRRSSLPRTSASANHLMNRNKSQIWNTTSATLNAFVNNTSSSSAASSALSNKKPGTPVFPNL-----------------DPTHSQTFHRANSLAYLPSILPEQDPLLKHNNSLFRGDYGNNISPERPSFRQPFKDQTSNLRNSSLLNERAYQEDETFLPHHGPSMDLLNEQRANLKSLLNLLNETLEKNTSERASDLHMISLFNLNKLMLGDPKKNNSERDKRTEKLKKILLDSLAEPFFEHYNFIGDNPIADTDELKEEIDEFTGSGDTTAITDIRPQQDYGRILRTFTSTKNSAPQAIFTCSQEDPWQFRAANDLACLVFGISQNAIRALTLMDLIHTDSRNFVLHKLLSTE--GQEMVFTGEIIGIVQPETLSSS---KVVWASFWAKRKNGLLVCVFEKVPCDYVDVLLNLDDFGAENIVDKCELLSDGPT---------------------------------------------------------LSSSSTLSLPKMASSPTGSKLEYSLERKILEKSYTKPTSTENRNGDENQLDGDSHSEPSLSSSPVRSKKSVKFANDIKDVKSISQSLAKLMDDVRNGVVFDPDDDLLPMPIKVCNHINETRYFTLNHLSYNIPCAVSSTVLEDELKLKIHSLPYQAGLFIVDSHTLDIVSSNKSILKNMFGYHFAELVGKSITEIIPSFPKFLQFINDKYPALDITLH--KNKGLVLTEHFFRKIQAEIMGDRKSFYTSVGIDGLHRDGCEIKIDFQLRVMNSKVILLWVTHSRDVVFEEYNTNPSQLKMLKESELSLMSSASSSASSSKKSSSRISTGTLKDMSNLST--YEDLAHRTNKLKYEIGDDSRAHSQSTLSEQEQVPLENDKDSGE------MMLADPEMKHKLELARIYSRDKSQFVKEGNFKVDENLIISKISLSPSTESLADSKSSGKGLSPLEEEKLIDENATENGLAGSPKDEDGIIMTNKRGNQPVSTFLRTPEKNIGAQKHVKKFSDFVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKKPHENILRLLDFFEDDDYYYIETPVHGETGCIDLFDLIEFKTNMTEFEAKLIFKQVVAGIKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAYVKSG-PFDVFVGTIDYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEILEGDLKFNNAEEVSEDCIELIKSILNRCVPKRPTIDDINNDKWLVI----------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q08217-1", "uniprot_id": "PSK2_YEAST", "id": "Q08217-1", "name": "Serine/threonine-protein kinase PSK2", "aln": "----------------------MTYPVSAAAPADISYSKN---------------TPLVGLSKP--------------------------------PCLYQHASSSVDS-FSSTFSDDDRSDLVAVPNESPHAFSYN-PISPNSLGVRLTILRRSLEIMVNSPDILHELK------------KKAPVIAYPPSLRHTRN-------LTETATLSASRD-PLNGSLISPLVSN-------MP-------------------SPASRPVIQRATSLMVLP---------------------------------------------------------------DNDTASKLNPAKSELENLLFLLNLALENNSFERASDLHMLSLLNIKKINFDSDIQ-------KSETLKKVLLDSLAEPFFENYKKFPHKDLGSKSQYNEYEEKHD---DIVSLADIKPQQDYSRILHPFTSAKNSGPEAIFTCSQQYPWNFKAANDLACLTFGISKNVIKALTLLDLIHTDSRNFVLEKIMNAEDDNQEIVFTGETIPIVQPNSTSNNNVPNLIWASLWAKRKNGLLVCVFEKTPCDYIDVMLNLRDFSVDSIIDTTHFLEN---------------------------------------------------------------------------------------------FDKKKQQE-------------------STSPMTEKKTVKFANEIHDIGSVSHSLSKLIDDVRFGKVFSADDDLLPLSIRVANHVNEERYFTLNCLSENIPCAVTTSVLENEIKLKIHSLPYQAGLFIVDSHTLSLLSFNKSVAKNMFGLRLHELAGSSVTKLVPSLADMISYINKTYPMLNITLP--ENKGLVLTEHFFRKIEAEMHHDKDSFYTSIGLDGCHKDGNLIKVDVQLRVLNTNAVLLWITHSRDVVIENYTTVPSQLPMLKENEIDVVGSRGSSSASSKKSSEKIPVNTLKAMADLSISSAETISNSDDEVDLNQVNEKLRETSCGKVRGIESNDNNNYDDDM------TMVDDPELKHKIELTKMYTQDKSKFVKDDNFKVDEKFIMRII-------------------EPINGEEIKKETNELD----------------KRNSTLKATYLTTPEANIGSQKRIKKFSDFTILQVMGEGAYGKVNLCIHNREHYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKNSQENILKLLDFFEDDDYYYIETPVHGETGSIDLFDVIEFKKDMVEHEAKLVFKQVVASIKHLHDQGIVHRDIKDENVIVDSHGFVKLIDFGSAAYIKSG-PFDVFVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWLKI----------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . . .: . : * * * ::. .:: ... : .: * .. * *.* ... :* : : : . . : : : : . :. : . * . :. . : . : . *: : : . . : .*: :: . :: : . :: .. . .: : *: : :.*: . :: : :: . : . *.:. * : . :*: .. . . . . :. . . . :: .. .: * . .. : .: . : * . . . .. :. .:: . . .. . . : : . ..:. : . :* . * . *. ::.: : : . :. ... :. : * .. .*: .: ::* : . * .: . .. : : .:: . : . :* . *: :: . . ..:: . ::. * : .. : . : . : *::. * :* :: : :.: : : .. .: . . * . * : : . : .: : :*.**:* * .:.:. . **:*:* **::* * *:.* *** :. ** *:: : : **::::*.**:: :: : **. :*** .*: : : * *. :*:*:*:.: :*: :.*:********::: .. :*:********:: * * .* **::*.***** *..*.* ::*::*: ***::::***: :::* :*. :: . **:: :.*:. :* :*.*::.: * *: ", "identical_positions": 121, "similar_positions": 331, "identity": "7.98%" }, { "cls_id": "homologset.agr.HGNC:17271", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P62070-1", "uniprot_id": "RRAS2_HUMAN", "id": "P62070-1", "name": "Ras-related protein R-Ras2", "aln": "MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIR-----------------KFQEQECPPSPEPTRKE----------------------KDK--------------------------------------------------------------------------------------------KGCHCVIF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5BJU0-1", "uniprot_id": "Q5BJU0_RAT", "id": "Q5BJU0-1", "name": "", "aln": "MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIR-----------------KFQEQECPPSPEPTRKE----------------------KDK--------------------------------------------------------------------------------------------KGCHCVIF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P62071-1", "uniprot_id": "RRAS2_MOUSE", "id": "P62071-1", "name": "Ras-related protein R-Ras2", "aln": "MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIR-----------------KFQEQECPPSPEPTRKE----------------------KDK--------------------------------------------------------------------------------------------KGCHCVIF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P04388-1", "uniprot_id": "RAS2_DROME", "id": "P04388-1", "name": "Ras-like protein 2", "aln": "---------MQMQTYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCNIDDVPAKLDILDTAGQEEFSAMREQYMRSGEGFLLVFALNDHSSFDEIPKFQRQILRVKDRDEFPMLMVGNKCDLKHQQQVSLEEAQNTSRNLMIPYIECSAKLRVNVDQAFHELVRIVR-----------------KFQIAER-PFIEQDYKK----------------------KGK--------------------------------------------------------------------------------------------RKC-CLM-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P01119-1", "uniprot_id": "RAS1_YEAST", "id": "P01119-1", "name": "Ras-like protein 1", "aln": "----MQGNKSTIREYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEIRDSELTSSATADREK----------------------KNNGSYVLDNSLTNAGTGSSSKSAVNHNGETTKRTDEKNYVNQNNNNEGNTKYSSNGNGNRSDISRGNQNNALNSRSKQSAEPQKNSSANARKESSGGCCIIC", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P01120-1", "uniprot_id": "RAS2_YEAST", "id": "P01120-1", "name": "Ras-like protein 2", "aln": "----MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYN---------KTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . *::************:***: **:** :********* ** *** : ***********:.********.*******:::..:.*::*: .: :** **** * .*::::*** **.:::**: ::. . :::: .::* *** :**::**: * *::* : : : *. *:: ", "identical_positions": 90, "similar_positions": 57, "identity": "26.87%" }, { "cls_id": "homologset.agr.HGNC:17272", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LZN8-1", "uniprot_id": "A0ABK0LZN8_RAT", "id": "A0ABK0LZN8-1", "name": "Centrosomal P4.1-associated protein", "aln": "MKMFLMPTSSELNTGQNFLTQWMTSPSRAGVILNREFPILDAD-EKQAATTVSASFPVKAAHFSSSFSISSEEDSFHEEQTLEAGRPYKPRSEDPEAHPVSASVRREP-IASCQDAPGCQEGNRNAATPDLKSEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQHMFPG-SLLPDELSQKHRSPGDSASGERATLSPPS--YPNPTQDNSRASSLLPDEQSNFCRATQQDSVLTSKNAS-DLFHESQYHEAHVRRNDLKEESHNHPSGEGALPCWEKKMGKSQEGKDVNLQRSRDSSGVVNIEERPIKAAIREKQQTFEDYLEEQIRLEERELRQKQLQEAEGPLLTKMKPKQPFLKRGEGLARFTNAKCKFQKGKESKLASTQSPSEQQSVPKVDRQHLQRKTALINRDLCADTTSVKKDSKARSKAGSASLRQKPKVTKTNRRDSLSPPGRKVQTGKKCDGQFRPQVKLERNVPTNNKENVPAYIKPWGAGCKVWNKTQGRDRLPLSTGPVGCVVSRSLVPETDRQTESSLDISLQKKLENWEREKEKENLELDEFLFLERAADEISFSSNSSFVLKILERDQQIYEGHRLSSTPVKAVQPQKAQQADPWGQSNHSEVPRPSVAHEDESEFEAMLLSRGS-GSP-GLRELSCKLSKKAFQNSTSENQGRWDAGDG-DVANSDSSSESEE-HDITIKPSTEAEDRVFSNREDSPQVCDAKGPSRDTGAQEDQWRDADLDLSDKECSSDESVTVESLSSQVLEPLRLPSSHDGSKVDFDDERSWADLEENPHEHGVVPREEAMSGTSQTHCHSTSEGCVLDKTIKRKIAPVKKGEDFSKSDRSVSPPPSDLMVKFFPSLKPKPKLDSHVENEPKLSLSQDQPP-------GDSVRSQVLREKVIELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYKKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIQELQEDLKRKETKWSSTHGRLRSQIEMLVKENTDLREEIKVMERFRLEAWKRAEAIENSPKACQYIMATKKDESMNSSIQFQKSHASLGVQGEKYKKKYLPAQDGVPHSSGNSSRRSKSVPPRDLGSLDKGQAALPREPLQPVN-FPDLEYKNKEEKEEEIQG---------EINHPDGKVEKVYKNGCRVVLFPNGTRKEVSADGKSITVTFFNGDVKQVMPDE-RVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFA---DGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q569L8-1", "uniprot_id": "CPAP_MOUSE", "id": "Q569L8-1", "name": "Centrosomal P4.1-associated protein", "aln": "--MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEAD-DKQAATNVSTSFPAKATHFSNSFSISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVRKEP-IASRQDAPGCQEDNNNDLTPHLESEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSAQHAFPG-TLLPDDQSQKHRSPGD------LTLPPHS--YSNPTQENSCASNVLPDEQSNFCRAT-QDSVLTSKNAS-DLFYESQYQEAHVKRNDLKEESPAHPSGEGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDERPIKAAVREKQQTFEDYLEEQIQLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAKSKFQKGKESKLASTQSPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLRQKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSKTQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEFLFLERAADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSNCSEIPRYGVAHENESECEAMLLSWGS-GSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDD-GVANSDSSTESEEQHDITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKECSSDESVIVESLNNKVLEPLRLPSSQAGSKIDFDDERSWTDLEENPYEHGVIHREEAIYGTPQTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRSQIEMLVKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHVSSGVQVEKYKKKYLPAQG-------NLSRRIKSAPPRDLGSSDKGQAALPREPLQQVN-FPDLEYKNKEEKEEEIQG---------EISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVKQVMPDE-RVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFA---DGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HC77-1", "uniprot_id": "CPAP_HUMAN", "id": "Q9HC77-1", "name": "Centrosomal P4.1-associated protein", "aln": "--MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESIL-CWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVP-QKTNPADPISHCNRSED-LDHTAREKESECEVAPKQLHSLSSADELREQPCKIR-KAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDES-IMESIKHKVSEPSRS-SSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQT-CYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPP-------GDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESS------LEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQG-------NPPRRSKSAPPRDLGNLDKGQAASPREPLEPLN-FPDPEYK-EEEEDQDIQG---------EISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQ-RVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFP---DGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRSGRIRVKDKEGNVLMDTEL---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VI72-1", "uniprot_id": "Q9VI72_DROME", "id": "Q9VI72-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------------MQEAGESPVGMPLSQEAIAQRLAALSRWQDEQKRLLQERQSNHRVLLGLEQRNMYKMLG------------------------------------------------------------------------------LLHQETESHENSVLEEWDEEHSIQMP-----------------------------------------------RLAADPDEHEPEISMAD---------------PQPAKPKRPFLRRGEGLK------------QRFKINPDQLRLENLPRYKFANAHPQFRTPQMKK------GILKKQVKSPPNP-----APPPAPKPSAQLDDLNEQRFQQMLIGKNACSSTPDLKS-SYASSTTASSTSPRVRFVEQKSRAGQTTHADDEASSEASPMTGVCWAKVLDTQSIKPAQIQRRSAQIRVE--------DDSNVSIFELLEQKATEGNIDMNSSCIRTFMARKD------------------QRRRVADDSDHIVVTQQVRQMRLQPQVDQMLVQELQEGD-----------------------------------------EEDTEPSSDQTLTMTPIQVGNTKVRVRFSDS---------------------------NDTHEYSDATSLNDGSNIQLFEQFKS--------------------------------------------------------------------------------------ALFQALEQKKKSSPSKESDEPITKDLQEKAN-------------LVRTRLEELETEIATFKEQNAQLLRLRQQHELEKAKCTQDHMEAMERVHDEKIQAEIYLHDERMKIEEERRKFEQQMRLQKSNANSKEKKEIAALKQEVEGLQLQLKQKEQAHVSAQARLRAQLRASEKEQRNYRDEIELLRKENKRLEQELVKIGRENNS-KMLQEINRNIARLAPKVLPSATMSDILDENGRRTQSLDGTAGKPAKQREAQNRRQSSGSAQVRSRSRSLSRNKKTPYALDESYASSSSVESEEVQPPVTAPKAATPPPAANSSSDFKREITNADGSKDIWYPNGNLKKISADGMNLRMLYFNKDIKETNIREGTVKYYYAETNTWHTSYLDGLEILEFPNGQTEHRRKDGTVEIHFPNNSIKIVDPSDTEKLEEWRYADGTHLVQLRNGDKILNLPNGQKEIHTKLNKRREYPDGTVKLVYPDGSQETRYSNGRVRLKDKDGKLIMDTDYAKY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . ::.: ::* *.. *::::. *:.:* :: * **.:: .*:. *. *:: :* * .: :*.. * : : * * :* : : ***:***:***** :. *: . * *: . *. . : * :*. :: :**: *: .:. * ..*. : * . ::* . :.. .... : . ..*:. :. . .:.* : . : :. . * * ::* :: ::. * :**: * * .:. *** : :: *.: :. . ** .: :: : . .: . . . :..::... :*:.* : .** .*.. ** : :. . :: * : :* :*: * * .. .: :. . :: . ::* :: ***:** .** :*:.* :** ::* * :: : :: * : * : ::* *:::**: **: :: .:.**::** :***:: *: :**:** *::.***:*:. :*: : *:**:::.: . :. : . : ::: :. : .: * : : :.: * : .* :* . :: . .:. : : * : :.. . .** : : . . .* * * :* : : :***. *::**** .: : :** *:*:. : * **** ::* **:* :***:*.*..** *:: ** ** **::::* : . : ** :.*** : *:*:*:::: ***:*:** *********** **.:* ***:* .**:*:***:*:::***: ", "identical_positions": 203, "similar_positions": 310, "identity": "14.66%" }, { "cls_id": "homologset.agr.HGNC:17273", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7TSP2-1", "uniprot_id": "KIF15_RAT", "id": "Q7TSP2-1", "name": "Kinesin-like protein KIF15", "aln": "MAPGCKSELRNVTNSHSNQPSNEDDAIKVFVRIRPAEEGA-RSADGEQSLCLSVLSQTALRLHSNPDPKTFVFDYVAGMDTTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSASVGLYLREHIKKGVFVVGAVEQVVASAAEAYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSEAVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLREQLSQFTS-------GQLTPGSSLARDKEKANYMEYFLEAMLFFKKSEQEKKSLVEKITQLEDLTLKKEKFIQSNKMIVKFREDQIMRLERLQKEARGSFLPEEQDRLLSELRDEIRTLREQVEHHPRLAKYAMENHSLREENRKLKLLAPVKRAHELDAQAIARLEQAFS---EVSSTETNDKGLQGLPPKAIKEPSFFTSTEKLKVQLLQIQTELNNSKQEYEEFKELTRKKQLELESELQSLQKANLNLENLLEATKVCKRQEVSQLNKIHAETLKIITTPTKAYQLCSRLVPKSSPEVGSFGFLRSQSAP--DNDILNEPVPPEMSEQALEAISEELRTVQEQLSVLQVKLDEEEHKNLKLQQNVDRLEH-------HSTQMQELFSSERSDWSKQQQDYLTQLSDLEKQLQDAQTKNDFLKCEVHDLRIVLNSADKELSLVKLEYSTFKESQEKELSQLSERHVQVQLQLDNARLENEKLLESQACLQDSYDNLQEVMKFEVDQLSKNLQNCKQENETLKSDLHNLVELFEAEKERNNKLSLQFEEDKENSSKEILKALET---VRQEKQEEMARCEKQMAKVQELEESLLAAENVVSCLEKSRESDKELVTNLMNQIQELRTSAGEKSEAIDTLKQELQDISCKYTAAVADKEESKELIRRQEVDILELKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQEKEEVEQKKSEYNLKMKQLEHVMGSAPEYPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKMSLQHLVTKLNEDREVKNAEILRMKDQLCEMENLRLESQQLRERTWLLQTQLDDMKRQGESSSQSRPDSQQLKNEYEEEIIRERLAKNKLIEEMLKMKTDLEEVQSALDSKEKFCHRMSEEVERTRTLESRAFQEKEQLRSKLEEMYEERERTCQEMEMLRKQLEFLAEENGKLIGHQNLHQKIQYVVRLKKENIRLAEETEKLRAENVFLKERKKE------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6P9L6-1", "uniprot_id": "KIF15_MOUSE", "id": "Q6P9L6-1", "name": "Kinesin-like protein KIF15", "aln": "MAPGCKSELRNVTNSHSNQPSNEGDAIKVFVRIRPAEEGA-RSADGEQSFCLSVLSQTTLRLHSNPDPKTFVFDYVAGMDTTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGIIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSASVGLYLREHIKKGVFVVGAVEQAVTSAAETYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLSQFTS-------GQITPESLLARDKEKTNYIEYFLEAMLFFKKSEQEKKSLIEKITQLEDLTLKKEKFIQSNKMIVKFREDQIMRLERLHKEGRGSFLPEEQDRLLSELRDEVQTLREHVEHHPRLAKYAMENHSLREENRRLKLLAPVKRAHEIDAQSIARLEKAFA---EVSSTETNDKGLQGFSPKALKESSFFTNTEKLKAQLLQIQTELNNSKQEYEEFKELTRKKQLELESELQSLQKANLNLENLLEATKVCKRQEVSQLNKLHAETLKIITTPTKAYQLCSRLVPKSSPEVGSFGFLCTESSSRLDNDILNEPVPPEMSEQALEAVSEELRTVQEQLSVLQVKLDEEERKNLKLQQNVDKLEH-------HSTQMQELFSSERSDWTKQQQEHVTQLSDLEKQLQDAQTKNEFLKCEVHDLRIVLNSADKELSLVKLEYSTFKENHEKELSQLSERHVQVQLQLDNARLENEKLLESQACLQDSYDNLQEVMKFEIDQLSKNLQNCKQENETLKSDLHNLVELFEAEKERNNKLSLQFEEDKENSSKEILKVLET---VRQEKQKEMAKCEKQMAKIQKLEESLLATENVISSLEKSRESDKELVTNLMNQIQELRISIGEKSETIATLKQELQDINCKYNASLADKEESKELIRRQEVDILELKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTRKEALIQELQHKLNQEKEEVEQKKNEFSLKMRQLEHVMGSATEYPQSPKTPPHFQAHLAKLLETQEQEIEDGRASKTSLQHLVTKLNEDREVKNAEILRMKDQLCEMENLRLESQQLREKNWLLQRQLDDVKRQQESGDQSHPDSQQLKNEH-EEIIKERLAKNKLIEEMLKMKTNLEEVQSALHSKEKACHRMSEEIERTRTLESRAFQEKEQLRSKLEEMYEERERTFLEMEMLKKQLEFLAEENGKLVGHQNLHQKIQYVVRLKKENIRLTEETEKLRAENLFLKEKKKEF-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NS87-1", "uniprot_id": "KIF15_HUMAN", "id": "Q9NS87-1", "name": "Kinesin-like protein KIF15", "aln": "MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERS-GSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELAS-------GQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFS---EISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEH-------HSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEA---VRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQ-EESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRSES----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58IVY0-1", "uniprot_id": "A0AC58IVY0_DANRE", "id": "A0AC58IVY0-1", "name": "", "aln": "------MNLKGKATAEANTNS-DGDAIKVFVRVRPLTQGTGLSTDGDHSLCLTVSSPQTVRLHCKPEPRTFTYDHVADMNTSQEEVFSSVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGPSELDNFSDELRGVIPRSFEYLFFLINREVERSGGTKSFLCKCSFIEIYNEQIYDLLDSVSTSLFLREDIKRGVFVEGSVEKYAASAAEAYQVLSMGWRNRRVASTSMNRESSRSHAVFTMTLESKETGQEVVNIRTSQLNLVDLAGSERQRDTHTEGSRLKEASSINRSLMCLGQVIMALMDVSNGKNRHICYRDSKLTFLLRDSLGGNAKTYIIANVHPGSKCFGETLSTLQFAQRAKLIKNKAMVNEDTQGNVRQLQAEVRKLKEQLANALSQGRIVELAPTDATSGTDQSEPEVSYKTQFIQAMNFWKKIHEEKKALQQKVSQLEAAWAQKEKFIQSNRMILKFRDDHIAQLKKELQTGQRSVEPEE---LNKQLQDEIRLLRDQVEHNPRMMRYAAENCSLREEIRALRALDSVKSAMESKAQSLTALEKTFLQLLEAQKTEDSNGAPPTYSTPVTMETLSSVSMERMKVQLLQKQSELTATIQAFEEFKEVTKKQVAELESERRYFEKSNKHLEKILEATKAHSKQEVSQLNKIHAETIKILTTPTKGYNLRNRLVPLSSPEH-----LNGQAEEMDVDDIQNEQPPPEMNELACEALTEELKQMQEQALRVQGQLDEEEAKNRKLLQQMSKLEEQVTIATEKSNRTEQMFGAERHSLQEEQERLQERIKTLEQQLDDEKGTMDVLQVEVRDLRVVLQSSDKELEATRTELQQQKEEHERETADLSKSLISTQLQLDTVKLEWEQVLEKQRVLQDTYDTLQAEFQFELDQHTQQMELKSRECSQLQTNINELLHTLQEEKEQNMSVKSQLTAHRESVSKELVQSVEENASLKKHITDLTNKNQQLCDEISSLQQSMSSSNGTINSLKQKIEQDKAVLLELMQEARDLRNDVAERDQTVCSLRAEIADITGKYSAVCAEKEQMKESITRMKSELQELREASDRRLASDRVELELLQEDLSYATDEMERLGKVVEEQTALLEASKSQNTEKENNINTLKEQVQQLNEQISLLR--VKESANQLPEAATPQGK-LQTPQTPCGFGSSLSQVLECQERELESRRSSMITMEVLLKELNAERTAKNQEIDRLKAQLNEKEIVRMEIQTLLDKFYTVQ-------NQQQKSNAQKDVNEAIQVSVLRELQEEKKLKNSLMAQLAESQAALQRNEVTLVQSQTCVQELTTELR-NRCLELRELRQKD----------QEQEKLQQEIEVLRKQVDHLTEENGKLLGHQNPKQKIEYLVKLKKEITKLQEENGKLRQCLHMEESPPTGLQHTHP", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*:. :...:* * :.********:** : : *:**::.:**:* * ::***.:*:*:**.:*:**.::*:**.**::***.******.********************:***: ****.:***:********* **:** *::*. ***********:***********.*..*:***.**:**** *:**: .:****:***** ************************:*:** *...* ****** ************:***:** *****..***** ****** **:**.***:**:********************* *********:*********:************:********* ******::*:***:: * . . * :.: :..* * :** *:** .:***:* :*::*** :********:**:***:*:* :*:: : .: .. *** * .:*::*:: **:::**:**: :** ** ***** * *: * .** * * .**::: **::* * . * .: .. . *. .. *::*.**** *:**. : * :*****:*:*: ***** : ::*:* :**::*****. .:********:****:**:*****.*:* .* ** *** * : :** ** ****.* * **::***: :*** :* :***** ** ** *::.:**. :*.: :::*.:** . ::*: ::. **:**:: : . :.*: **:***:**:*:****. .: * . * .:*:* .**: : .*****. :** *::**.: ***:**.** ::**:** ::::: .:* . *::::::*:. :: ***:* .:. *: .:*. ***::: :* :::. . : :: ::..*::*: ::: .:..*::. :.** :: :**:: ::** . *: ::: :*: *: **. **.: .::*: : * : : :: :*:*: *: *: :* ::* ***::**:::: * :. ::::.**::::.: *.** *: *:.:::* :*::. : . . .** .. . : *:*:** * : *:::** **:*:*. *:* ::: *:.:** :* .** ** *:* ** * * :*:* * * :: : :* .* :... .: .: :: . .* .*: *..:: :: : :: *:. : :* ..: .:: *:. .: ** : :::*: :*:*: *:*:*:**:: *:******:**** :***:*:*:**** :* **. *** : :. ", "identical_positions": 619, "similar_positions": 443, "identity": "43.78%" }, { "cls_id": "homologset.agr.HGNC:17274", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AB12Y1Z1-1", "uniprot_id": "A0AB12Y1Z1_DANRE", "id": "A0AB12Y1Z1-1", "name": "", "aln": "---------------------------------------MAEYSDSSQKQ-----------------TLSEELQCSICLDAFTDPVSTPCGHNFCKSCLNQCWNNSQTYNCPLCK---ETFNKKPELKINTALR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLVQKTSEKDKADCIELFADLMRCIERCQSELLKMMEQKQKAAEKQAEELINDLEQEITELKRRDAELEQILHTEDHLHLLQIYPELSK-PPHIRSWTHVSISDTQLSVETLRKTLTQLHDKQELRLTKTV---LKRMQQNTVDVTLDPDTAYSKLILSDDRKQVTYGATVQKLPANPKRFDSCCSVLAKEGFNSGKFYFEVQVKGKTDWDLGVARESVNRKGTITGSPVNGYWIIVLRNGSQYKARESPTVSLSLKVKPQVVGVFVDYEEGLVSFYDVESSSLIYSFTGQTFSEKVFPYFSPGTTNEGKNAAPLIILNVKNNM----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9Q7G6-1", "uniprot_id": "A0A8M9Q7G6_DANRE", "id": "A0A8M9Q7G6-1", "name": "", "aln": "---------------------------------------MEESPRGTRTQDSSKSLIS------STGPLSEELQCSVCLDVFIDPVTTPCGHNFCKTCLEKYWHNSRDYSCPICK---ETLHQKPELKVNTTLREIADHYKKK---------------------------------SNLEMAEVFCDFC-TDTKKKALKSCPLCQSSYCEAHLERHLTVPGLKQHKLINPVKNLQGYLCQEHDRPLELFCRDDQTCVCVTCTVTEHKMHNTVPVEEESEEKKNQLMKTQTDMQQLIQDRMKMIKEIQHSVELRKKNNEKEKADCVEVFADLMRSIERCQRELLEVTEQKQKAAEKQAEELIKELEQEISELRRRNTELEELSHTEDHLHLLQMFPSLCR-PLDIKIWTGININ-TGVSVETLRSALSQLQETIDEGFNNNV---LKRIQKYSVDVILDPDTAHPKLILSEDGKQVRYGNIKHDRPGSDKRFENYIVVLGKEGFSSGRFYFEVNVSGKTEWLLGVARESLNRKGEFFLSPNDGNWSLWLKDENKCEACESLTLSLSLKVKPQTVGVFVDYEEGLVSFYDVKSRSHIYSFTGQSFTEKLYPFLSPLSNNKGQNSAPLIISPVTGND----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M3ASA8-1", "uniprot_id": "A0A8M3ASA8_DANRE", "id": "A0A8M3ASA8-1", "name": "", "aln": "---------------------------------------MAESSPESSRRESRRRSQNGLPPSLSSSDSLRRLRCSICVKVFTDPVSTPCGHIFCKSCLNKCWENKQTISCPFCG---NTLTQRPDPEINTT-----------------------------------------------ENTEVVCDVC-EDRKLKAVKSCLVCQSSYCQTHLEPHLRVAGLKKHKLMDPVRNLEDYICQKHDRPLELFCRDDEKCVCPFCLEGDHKEHITVRIEEEIDERK-------IDVQQKIQEKTKKIEEIKKTAEDRKINSEKEKAAHVEIFTDLIRSIERCQTELLEMMEEQQKAAEKQEEELIEELEQEITELQMRETELEQLSHTEDHLHLLQIYSSLCS-TTDSRSLPDINAK-THENLENRRKTLIQLKGNIEEKLEQTLSEELKWVQKHAVDVTLDPDTAHVGLILSKDEKQVRLGEIIQKLPDKPQRFEKCVCVLGKEGFSSGRFYFEVQVKGKTKWDLGVARESVDRKGEIRLCPSNGFWTVWLRK-NEYKALASPSVPLSVKVKLQRVGVFVDYEEGLVSFYDVESSSHIYSFTGQTFTDKLYPFFNPCSNIDGNNSDPLIITPLGDNKK---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2BL34-1", "uniprot_id": "A0A8M2BL34_DANRE", "id": "A0A8M2BL34-1", "name": "", "aln": "---------------------------------------MSSSSGPLS----------------------EELQCSICLEVFTDPVSTPCGHNFCKSCLNTYWNNSQTCSCPYCK---ETFTQRPDLKINTTLREISEHYKEK---------------------------------NPAKKPRIMCEIC-EGRKLKALKSCLVCQSSYCQTHLEPHLRVAGLKKHKLMDPVRNLEDYICQKHDRPLELFCRDDQTCVCSFCTVKDHKNHNTVPLEEDIEEKKTELMKTQKDVQQMIEDRIKKIQDIKHSAEVRKIYSEKEKAAHVEIFTFLIRSIERCQTELLEMMEEQQKAAEKQEEELIEELEQEITELKMRNTKLEQLSHTEDHLHLLQSYSSLQSRPADTRNWPEISLK-TQENLETLRKTLDHLKDTVEEKLSQAVSAEVKWVQQYAVDVTLDPDTAHPEIILSDDGKQVKHGDIRQKLPDTPQRFDRCPCVLGKEGFSSGRFYFEVQVKGKTDWTLGVVRESINRKGSITVSPSNGFWTVVLRNGNEYKAFAGPSVSLSVGVNLQRVGVFVDYEEGLVSIYDVESSSHIYSYTGQTFTDKLYPFFSPHLNNGGKNSNPLIITPLHYNK----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1NTY9-1", "uniprot_id": "A0A8M1NTY9_DANRE", "id": "A0A8M1NTY9-1", "name": "", "aln": "---------------------------------------MSSSGGPLS------------------------VELSVCLDVFTDPVSTPCGHNLSK--------NSQ--ICQYTK---ETLNQRPDLKINTTLREISDHYKLK---------------------------------SPDEGAVVVCDLC-EDR--TAVKSCLVCQSSYCETHLQPHLKVTGLKKHKLMHPVSNLEDYICQTHQRPLELFCRDDHMSVCLHCAVTDHKTHNTVLLEDENQKMKAQLMETQRDLQKRIQDRFKEIQDIEQSAEAR----------------------RRVYTDLLKLMEDQQRAAEEQDSERMSALEQEISELESRNTELEQLSHTEDHLHLIQIHSSLSS-FRNTRSRSEISRK-TRETLK---RALIKLKESIDEKLEQTVSADLKWMQQYAVDVTLDPHTAHPELILSDDGKQVSCGDIWQKLPNKLERFNRYLSVLGREGFSSGRFYFEVLVKGKTDWTLGVARESVDRKGDIRVSPETGSWTVALINGNELSARADPPVLLSLRVSPQRVGVFVDYEEGLVCFYDVESSSHIYSYTDQCFSEKLHPCFSPGFNFEGKNSTPLIITHLSYNH----------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8N7TE82-1", "uniprot_id": "A0A8N7TE82_DANRE", "id": "A0A8N7TE82-1", "name": "", "aln": "---------------------------------------MASPSSMLA---------------------EEQVHCSICLDVFTNPVSIPCGHNFCMACIGSYWKSSALFMCPMCK---KTFFKQPDISINTVLREIAEKFKEMKRNPIVSLQSATQPDPTPSPVELPIEMPELIPPNAPWAQEVSCDVC-TGPQRRAVKSCLVCLTSYCEEHLKTH--TVRFTKHKLIEPVLNLEDRMCKKHERLLELFCKKDQTIVCVLCTEMEHRAHYTIPVEREWAEKKALLRKTESEVQQMIQDRLKKVDEIKHSIELNKSGAQREVEDSMQVFSDLIRALQKAQAELVLDIEEKQRKTESRANEQIQELEQEITVLKTRNEELEYLSHTEDHIHFLQNFPSLMS-HPHTKDWSEICVH-ADPCVGTIRRAVLKLEETLTEEVEKLAEAELRRVQKYSVDVTFDPDTANPWLQLSEDGHQIRHLGSWQDLRDAPERFDTVVIALGRQGFCSGRRYWEVQVGEKDDWYLGVARGSVNRKGRISVSTTQGYWALAMKKGQEYRVSSSPPLLVSVEHKLKRVGVYVDYEEGQVSFYDVQNKSHIYTFM-DTFKEKLFPFFYLYCCD--KASDTMIICPVQETPHTKQC-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6YWG8-1", "uniprot_id": "A0A8M6YWG8_DANRE", "id": "A0A8M6YWG8-1", "name": "", "aln": "----MQCWWSFRYVVEKHCTFWLSLVCHSFIFDFSMFLVMSSSTPFLS---------------------EELFQCSVCLDVFTHPVSLPCGHTFCQSCVLAQWTASGSSHCPKCS---AVFQETPDLCENSFAREMAEQIRKQKGQTQKS-------------------------SRPVKAKVVFCDMCPLEKASHAVKSCLVCVASYCEAHVTSH--TSRFTKHTLVQP-QSMDKRICRIHERPLELYCRYDQSAICVLCMNAEHNTHHSVPVEREWMERKTQLSKTQTDLKRMIMERWSKVEDLRHSIKLSKENTEREMAHSVEVFTTLQQIIEKSQKELLRKMKHKQKSAEKHVERLIKELEVEIAKLNTRNSELERLSSSEDHLCLIQAFPTLSE-VPHCKSWSQISAH-TCEGLELLRETLNAAEELLKTQIHSATKRELEAISQYAVDLTLDHDTANSWLAVSEDRKSVSDGNVERNFQNNTQRFDTAPCILSKEPISRGRSYWEVGVSGKTAWDLGVARKSVNRKGLVTLSPEDGYWAVCLRNGCEYRACNRESELLSLKSLPQTIGIYVDFENGRVSFYDTCACGHIYSFTGQRFTESLLAYFNPDMNDTGNNNAPLVIQPVRVDSGAKIYDTVTI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0G2K659-1", "uniprot_id": "A0A0G2K659_RAT", "id": "A0A0G2K659-1", "name": "Tripartite motif-containing protein 29", "aln": "MEGADASRSNGASPEARDARSPPGPNGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEARR-------------NSYPRADSSLLLRSKSGSEEVLCDSC-IGNKQKAVKSCLVCQASFCDLHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLG------QSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNNYTSSYGNEWSTPDTMKRYSMYLTPKG-----GGRTSYQPSSPNR-------LSKETNLKNFNNLYGTKGNYTSRVWEYSSTVQNAD-DMPTVQGNSSFSLKGYPSLLRSQV----PKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP--------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R2Q0-1", "uniprot_id": "TRI29_MOUSE", "id": "Q8R2Q0-1", "name": "Tripartite motif-containing protein 29", "aln": "MEGADACRSNGASPEARDTRSPPGPSGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEVRR-------------NSYPRADSSLLARAKSGSEEVLCDSC-IGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDDVEKWQKEKDRIKSFTTNEKAILEQNFRDLVRELEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHNISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLG------QSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNSYTSSYGNEWSTPDTMKRYSMYLTPKG-----GGRTSYQPSSPSR-------LSKETNQKNFNNLYGTKGNYTSRVWEYTSTVQNSE-DMPTVQGNSSFSLKGFPSLLRSQV----PKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP--------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q14134-1", "uniprot_id": "TRI29_HUMAN", "id": "Q14134-1", "name": "Tripartite motif-containing protein 29", "aln": "MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRR-------------NSYPRADTGLFSRSKSGSEEVLCDSC-IGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLG------QSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKG-----GVRTSYQPSSPGR-------FTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQS----PKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP--------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : * .. . :. .: : : . . .: :: :.::: : .: . :. *: . *. . * : .* : ::* . * . : . . . :: . . :*:. . : :: : . *. * : : . . : : . .. :. : : . . . . ", "identical_positions": 10, "similar_positions": 74, "identity": "1.55%" }, { "cls_id": "homologset.agr.HGNC:17276", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C460-1", "uniprot_id": "ERI3_MOUSE", "id": "Q8C460-1", "name": "ERI1 exoribonuclease 3", "aln": "MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTDPSASPAASLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLLSPCGVPELCSISTRKLAAHGFGAAMAAMVPFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCHYLGLPVADYFKQWINLKKAYSFA----MGCWPKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRG--------FIFKQTSKPF---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43414-1", "uniprot_id": "ERI3_HUMAN", "id": "O43414-1", "name": "ERI1 exoribonuclease 3", "aln": "MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTEPSASPAAGLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLFSPCGVPEFCSISTRKLAAHGFGASMAAMVSFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFA----MGCWPKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRG--------FIFKQTSKPF---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M0R8C5-1", "uniprot_id": "M0R8C5_RAT", "id": "M0R8C5-1", "name": "", "aln": "MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTDPSASPAASLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLFSPCGVPEFCSISTRKLAAHGFGASMAAMVPFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCHYLGLPVADYFKQWINLKKVQAEDSAELCGLFPEQ-LQGQHLDLSVDYHCQPWMLKVLSMTEAPALGGLQLRHGLLAQEWTTRHEQGPQPATHRPAPQRH", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****************************************************:*******.********************************************:*******:***************:*****.*************************************************************************************************************************:******************. : * :*:: * . : .**::: :* . . * : * * .:* .:* ", "identical_positions": 281, "similar_positions": 26, "identity": "78.49%" }, { "cls_id": "homologset.agr.HGNC:17277", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q562A2-1", "uniprot_id": "ZFR_RAT", "id": "Q562A2-1", "name": "Zinc finger RNA-binding protein", "aln": "MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQARQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAAT--VVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKTPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQVFILCIYHESQCTFTSVYSVLCNSPIDQ---KDACG--KLHLCRLCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAVSASKPTASPSSIGASNCTLNTSSIATTSVKGLSTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGGGNKLQSTGNKAEDLKGTDCIKNNPAASAVQIPEVKQDAVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWR-MEIRRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMP-PQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEK---SKNKEGD-DKKEG--GKD-----------------RSLKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKSLLSRIAENLPKQLAVIS---PEKYDIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGNPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMNQRFN-IHNNRKRRRD---SDGVDGFEAEG----------KKDKKDYDNF-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O88532-1", "uniprot_id": "ZFR_MOUSE", "id": "O88532-1", "name": "Zinc finger RNA-binding protein", "aln": "MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQARQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAAT--VVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKTPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTSSSN---NSTRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAASASKPTASPSSIGASNCTLNTSSIATSSVKGLSTTGNSSLNSTSNTKVSAIPTNMAAKKTSTPKINFVGG-NKLQSTGNKTEDLKGIDCVKNTPAASAVQIPEVKQDAGSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWR-MEIRRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMP-PQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEK---SKNKEGD-DKKEG--GKD-----------------RALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKSLLSRIAENLPKQLAVIS---PEKYDIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMNQRFN-IHNNRKRRRD---SDGVDGFEAEG----------KKDKKDYDNF-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96KR1-1", "uniprot_id": "ZFR_HUMAN", "id": "Q96KR1-1", "name": "Zinc finger RNA-binding protein", "aln": "MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAAT--VVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTSSSN---SSTRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAVSASKPTASPSSIAANNCTVNTSSVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGG-NKLQSTGNKAEDIKGTECVKSTPVTSAVQIPEVKQDTVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWR-MEMRRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMP-PQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEK---NKNKEGD-DKKEG--GKD-----------------RALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVIS---PEKYDIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMSQRFN-IHNNRKRRRD---SDGVDGFEAEG----------KKDKKDYDNF-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6PCR6-1", "uniprot_id": "ZFR_DANRE", "id": "Q6PCR6-1", "name": "Zinc finger RNA-binding protein", "aln": "MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHG------AGAQYSQQPAAGVAYTHPTTVASYTVHQAPVAAHTVAAAYAPTAATVAVARPAPVAVAAAANAAAFGGYQPAHAATDYGYAQRQPEVPPPPPPVTSQNYQDSYSYVRSTAPAVAYDSKQYYQQPAATPAVAAAAAQPQPTVAESYYQTAPKTGYSQGATPYTQTQQTRQVTVVKPATPSPATSTFSIYPVSSAVQPVAAAAAASVVPSYSQSPTYSTNAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQ---AAVAAAATAAWTGSTFTKKTPFQNKTLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEAALKVSQSSSSSSGGGSSARGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPSVVSQSSTSSTAAPNKTSSSNINSSTSTSSNASSSVSASYLKSGSMAASAAQGKSSGANNVSVNS-SSIKKVNTPKINFVGG-NKLQTTASKSDESK-ADAAKTAQSAASAPAADAKNDMPDPMSPQSALAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWR-MEMRRYEEDMYWRRMEEEQHHWEDRRRMPDGGYPQGPPGPPGLLGVRPGMPIPQPQGPVPPRRPDSSDDRYVMTKHAAIYPSEDELQAIQKIVSITERALKLVSDIITDQDAGASAKGKEEDKEKKEP--PKD-----------------RLLKGVMRVGVLAKGLLLRGDKEVNLVLLCSEKPTKNLLTRIVEHLPKQLTMVT---PEKYEVKGSIQESAIILTSCGDPKMQVTITLTSPIIREESSRDGDVTSSMVKDPADVLDRQKCLDALAALRHAKWFQARANGLQSCVIVIRILRDLCQRVPTWSAFPSWAMELLVEKAISSASGPMSPGDALRRVFECISSGILLSGAPGLIDPCEKNPTDTLAFMEEQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMNSRFN-VRNTRKRRRDN--SDGADGFEAEG----------KKDKKDYEGF-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q86BI3-1", "uniprot_id": "Q86BI3_DROME", "id": "Q86BI3-1", "name": "", "aln": "----------------------MANNNYAGFNYG-------GTQYNTGQVSYPAVTNATYANAAAYQNAAVAAG--QGGYGGAAGAGAGATSGPG-------AGGYGGYGDYRSAMQYDAT------------------------------------KTFYQQSPASYNASGSTA----SVSKTHYSAPPVKNQVKGKMDKSNGGP-------KPPSSAPP-----------------------------------------AGNNYSGYDTALYNAASMYVAQQHQGNPNQKPNGGANNWYQRKMGATIPGATAIRG--MRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSAT----QNRG--NNYHCELCDVTCTGTDAYAAHVRGAKHQKVVKLHQKLGKPIPSEEPKKMG-----------------------------------------------------------------------KINFVPA------------AAGGAGVAKTEGGANESDAAGDLDDNLDD-----SLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEARANRAMMSSHRGGDDHDGGYWEEQRNRQYNEEYDYN-------NWMSRSFGGAQRFGRMGNGPPPHFGMMPGGN---------VRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIV---LDESVSVKITLTSPLLRDANPGEAATTDEGEGD-SEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLING-PGLLDPCEKDPTDALLELTKQEREDLTVSAQLFLRYIAFRQIYKVLGMEPLPAMKFPMRPWRVNRKRRRSSGKAGGAPGTETESNDIDETGSDEKVAKKEGVGGTPAST", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **..** **.:. .:**. .: * ::.* . : : ::*.*** ..*. :*.: * * ..* *..:*** ::* :*. : * :***..*: . .::* :*::::*.:.* . :* :: **.:.:*. :*..****::*:*.*** * **:* : : . * *:*:. :.::. ::** **:* *:***:**********.: : :.: . : . .: . * : *.****:***:******:************ ******** **. :. ***** . *. : . :* . :*. .:::*** :*:***:::***:: *:****:*.**********:**********:**:*** *:.**: * *:: * : .: * ... .: *. . *:*:*: :. :* .* : : ** :*: ** ***:*:***:.:::** ***.*:***::*:*** ********** :::: .*: . :* . :* * ****:*** *******:**. *:**:**:***:. ** *:.: **.:* :: :* :: .*:*:*: : .:.*.******::*: . :. .*. * .:.* *: ** *** ***********.******::***********.:*. :*.*::******.****. * ****.:**::*.:***:::.* ***:*****:* *:* : .*:***:* ***: ** :*****:*****:*** *. :. : .*****. :.*. * *:*. * **: . ", "identical_positions": 363, "similar_positions": 262, "identity": "32.21%" }, { "cls_id": "homologset.agr.HGNC:17278", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q12796-1", "uniprot_id": "PNRC1_HUMAN", "id": "Q12796-1", "name": "Proline-rich nuclear receptor coactivator 1", "aln": "MTVVSVPQREPLVLGGRLAPLGFSSRGYFGALPMVTTAPPPLPR-----IPDPRALPPTLFLPHFLGGDGPCLTPQPRAPAALPNRSLAVAGGTPRAAPKKRRKKKVRASPAGQLPSRFHQYQQHRPSLEGGRSPATGPSGAQEVPGP-AAALAPSPAAAAGTEGASPDLAPLRPAAPGQTPLRKEVLKSKMGKSEKIALPHGQLVHGIHLYEQPKINRQKSKYNLPLTKITSAKRNENNFWQDSVSSDRIQKQEKKPFKNTENIKNSHLKKSAFLTEVSQKENYAGAKFSDPPSPSVLPKPPSHWMGSTVEN-------------------SNQ---NRELMAVHLKTLLKVQT---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q63647-1", "uniprot_id": "PNRC1_RAT", "id": "Q63647-1", "name": "Proline-rich nuclear receptor coactivator 1", "aln": "MTVVSVPQRD-LALGGRLAPLGS-----LGALPMVSPAPPPLPR-----LPDPRALPPTLFLPHFLGGDGPCLA---RASHRCTVQLQLGPGRCPTAAPKKRRKKKVRASPAGQLPSRFHQFQQHRPSLEGGRSPVPGPIAAQEERGPGATALLYR-----------------------QPPLAKEVLKSKMGKSEKISPPHSQLVHGIHLCEQPKISRQKSKFNLPLTKITSAKRNENDFWQDSASSDRMQKQEKKPLKNTENIKNNHLKKSAFLTEGSQKENYAGAKFSDPPSPSVLPKPPSHWMGSTTEN-------------------PSQ---SRELMAVHLKTLLKVQT---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5TZ15-1", "uniprot_id": "Q5TZ15_DANRE", "id": "Q5TZ15-1", "name": "", "aln": "------------------------------------------------------------MLGDAFGR---------RVESSVDNKAVKINRSKQVLLKKRGRNVHSKANNTSANIHRGSANEELKPAQSKPAPNKQQPKSCTAERGS-------------------------------------------------------------------QISRAS---ILNCSRLEQTTDNLN--RRTHQSKHQINARQDKPTS-TEKSPENILKQGNASTSSDAEKTYAGAKFSEPPSPSVLPKPPRHWVGDHAPQ-------------------HTHKHCSREQMSEHLKTLLKVQTDSL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VHK8-1", "uniprot_id": "Q9VHK8_DROME", "id": "Q9VHK8-1", "name": "", "aln": "MTYSHNSVRNNIRMTTASATKSIRLKKGAASATSASNSSTPSPTSAPVSPTSVSASAPATPLVTAHSNSIASSTNNAQFLSSSPTSLGFGLGLSALATPPNQRQRQLQSQSTGSKNKYQQSQQQRQSPQQQQGSSVGGGGFFFANNN--------------------------------------------------------------------RRNGGGRSPQGAMQVRQSPATILGGGFSPGIVGGSARKQRKSPSLGGKISPQHQMQQHPLIP--TALTHFAGSKCFDAPAPTALPKPPQHWTLSRSEGKLPMMMPSMPKFQVPMQTGRSKRNLLDDFDTHNLKLLLNVQS---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . : . *: : ::. :. :: :.. . . . : . .. . . :...* : : ::: . :**:* :.*:*:.***** ** . .: : : :** **:**: ", "identical_positions": 21, "similar_positions": 49, "identity": "5.87%" }, { "cls_id": "homologset.agr.HGNC:17279", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9PTY1-1", "uniprot_id": "E9PTY1_RAT", "id": "E9PTY1-1", "name": "", "aln": "MKRETFILGLLALLSYFTPGESHHFQPKPHPYQRLQQPIYHRRHSQVSSIYPRYGQYPRYFYVSQKQQAQKPQILPIQTPWQRVCPPGYTARLLHYHYSRFLCIPNKQLTSDKIETKVTTPAQTTKPTTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTNKPTTDSTTPAPTTKPTADSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTTKPTTDSTTPAPTTKIPTTPKPSTSTAIPTSTNSANSSSSTTTSSTTIQTTTLSPFQQMLQWLQMYFG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99935-1", "uniprot_id": "PROL1_HUMAN", "id": "Q99935-1", "name": "Opiorphin prepropeptide", "aln": "-MKLTFFLGLLALISCFTPSESQRFSRRPYLPGQLPPPPLYRPRWVPPSPPPPY-----------DSRLNSPLSLPFVP--GRVPPSSFSR-----------------FSQAVILSQLFPLESIRQPRLFPGYPNLHFPLRPYYVGPIRILKP------PFPPIPFFLAIYLPISNPEPQINITTADTT----ITTNPPTTATATTSTSTKPTMTISSSTVPISSTPEPATSISAATPAASTENTTQILANRPHTVL------------------LNATVQVTTSNQTILSS--PAFKSFWQKLFAIFG", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : **:******:* ***.**::*. :*: :* * :* : .* * * ..: :.* **: . ** *..:: ::. * ::: . . :* . * . . * ** * *. * ...:* : **. .* :..*:.:* .*: **.*: * ..:* . :.:* . .: .::***.:*: **: : * * : *:: ..***. ** :: ..*:.: * * **", "identical_positions": 69, "similar_positions": 85, "identity": "22.33%" }, { "cls_id": "homologset.agr.HGNC:1728", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4V8A2-1", "uniprot_id": "CDC27_RAT", "id": "Q4V8A2-1", "name": "Cell division cycle protein 27 homolog", "aln": "----------------------MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEE--------ALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSG---GVFNKQKSHDDLVTEFGDSACFT------LSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSS----CLPNT--CTALVSNHSLSHRQPETVLT--------------ETPQDTIELNRLNLESS-------NSKYSLNTDSSVSYIDSAVISP-------DNVPLGTGPSILSKQVQNK----PKTG---RSLLGGPTALSPLTPSFGILPLETPSPGD-GSYLQNYTNTPSVIDVPSTGAPTKKS-VARMGHTGAKSVFSQSGNSRE---ATPVLVAQTQSSGPQTSTTPQVLSP---TITSPPNALPRRSSRLFTSDSSTTKEN-SKKLKMKFP-PKIPNRKTKSKTNKGGITQPNINDS------------LEITKLDSSIISEGK--------------ISTITPQIQAFNLQKAAAG-LMSLLREMGKGYLALCSYNCKEAINILS-HLPSHHYSTG-WVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQ---IMGTDESQESSMTDADDTQLHAAESDEF-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2A6Q5-1", "uniprot_id": "CDC27_MOUSE", "id": "A2A6Q5-1", "name": "Cell division cycle protein 27 homolog", "aln": "----------------------MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEE--------ALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSG---GVFNKQKSHDDLVTEFGDSACFT------LSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSS----CLPNT--CTTLVSNHSLSHRQPETVLT--------------ETPQDTIELNRLNLESS-------NSKYSLNTDSSVSYIDSTVISP-------DNVPLGPGTAILSKQVQNK----PKTG---RSLLGGPTALSPLTPSFGILPLETPSPGD-GSYLQNYTNTPSVIDVAPTGAPTKKS-VARMGQTGTKSVFSQSGNSRE---VTPVLVAQTQSSGPQTSTTPQVLSP---TITSPPNALPRRSSRLFTSDSSTTKEN-SKKLKMKFP-PKIPNRKTKSKTNKGGLTQPSINDS------------LEITKLDSSIISEGK--------------ITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILS-HLPSHHYSTG-WVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQ---IMGTDESQESSMTDADDTQLHAAESDEF-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P30260-1", "uniprot_id": "CDC27_HUMAN", "id": "P30260-1", "name": "Cell division cycle protein 27 homolog", "aln": "----------------------MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEE--------ALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSG---GVFNKQKSHDDIVTEFGDSACFT------LSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSN----CLPNS--CTTQVPNHSLSHRQPETVLT--------------ETPQDTIELNRLNLESS-------NSKYSLNTDSSVSYIDSAVISP-------DTVPLGTGTSILSKQVQNK----PKTG---RSLLGGPAALSPLTPSFGILPLETPSPGD-GSYLQNYTNTPPVIDVPSTGAPSKKS-VARIGQTGTKSVFSQSGNSRE---VTPIL-AQTQSSGPQTSTTPQVLSP---TITSPPNALPRRSSRLFTSDSSTTKEN-SKKLKMKFP-PKIPNRKTKSKTNKGGITQPNINDS------------LEITKLDSSIISEGK--------------ISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILS-HLPSHHYNTG-WVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQ---IMGTDESQESSMTDADDTQLHAAESDEF-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58ICN3-1", "uniprot_id": "A0AC58ICN3_DANRE", "id": "A0AC58ICN3-1", "name": "Cell division cycle protein 27 homolog", "aln": "------------------MVKDPVLVISAQFAAVWHALNHYAYRDAVFLAERLYAEVHSEE--------ALFLLATCYYRSGKAYKAYHLLKRHSCTTPQCKYLLAKCCVELSKLAEGEQILTG---GVLNKQKSQDDIITEFGDSACFT------LALLGQIYCKTDRIAKGAECYQKSMSENPFLWSPFESLCQIGERPDPEQIFRLTSLQNFSGGSGGGIPPSPISPAHTPSNNMGHRQVDTVLM--------------ETPQETLEQNRLNLESS-------NSKYSLNTDSSVSYIDSSVISP-------DSVPLSSSGSLLSKQVQNK----PKSG---RCLLGGTATLSPLTPSFGILPLE-PSPGD-PAYLQSYGHSGTGMEPPPAPGPPKKA-VSRIRTVGTKSVFAQSGNSRE---VIPNPFIQTQTTAPQTSTTPQVLSQ---TIAAPPNVQPRRSSRLFTSASSTAKEN-SKKLKMKFP-TKIPNRKTKTKTGKGGITPSNLNES------------IEILKLDSS-LSEGK--------------GNISSPQFQAFNLQKAAADGLMTLMRDIGRGYLALCSYNCREAINILS-QLPSHHYNTG-WVLGQIGRAHFELAEYMQAERIFSEVRRIESYRVEGMDIYSTTLWHLQKDVALSALSKDLTDMDKNSPEPWCVVGNCFSLQREHDIAIKFFTRAIQVDPSFAYAYTLLGHELVLTEELEKALGCFRNAIRLNKRHYNAWYGLGMIYYKQEKFNLAEIHFKKAFSINPQSSVLLCHIGVVQHALKKSDHALETLNRAISIDPKNPLCKFHRASILFANEKYKAALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDDEPVTPDDYPYCSTEVEESQESSMTDADDTQLHTTESDEVL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VS37-1", "uniprot_id": "Q9VS37_DROME", "id": "Q9VS37-1", "name": "Cell division cycle protein 27 homolog", "aln": "-----------------------MMIQEPVQAAIWHCLNYYDFKDAVFLSERLCSEVESDE--------TIFLLATSYFRSNQVHQAYWLLKEKARRSPQCRFLQAKCAYELKKYAEAESALIS---TGFADAKNCDELQRDFGDLACFA------YQLMAQICMRTERNKLAVSALRRALKLNPFMWHAFADLCLLGQDTDAAAIFQIHSTDVFNTCQGSSVNANAMVLFGAEQQGQQHQERQSLITNLSNVSNYILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNLNSSISMLRGGLVQNSSMLAMLEDTPMGAPQDPAGQYQQNQQLYDMSSGTPFRKQFKYLSAISPPTPSFGIMPLTSPCTGNDGSFIGNHTPVMNISYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRKEGSLNKPAVFTQAGNITPRTPNNNNVGNNGNMNVPPNPNAAVRRSSRLFSNSYSVKENNKSPNIANKFVQPRSPPRKAKSRMTKICLNNELIEDKSHHLSEKRKEKVETITSSGANNNSGGRSAAEEAKVLLNNSLNNAQTMAHQLMGLKKQSADGLMALLRGLAEAYQLLSNFQCKAAIKQLETTIPKHHLNSS-WVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQREVELSALAQDLINQDKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVLTEEFDKAMDYFRAAVVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGAMQFYMKKKDLSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYLIGKIHKTLGNMDLALMHFSWATDLDPKGANNQIKDAFDSMAHPSCCPANTTALD----VDLEPTSERSDDSTQAQQDGSYDSDY--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38042-1", "uniprot_id": "CDC27_YEAST", "id": "P38042-1", "name": "Anaphase-promoting complex subunit CDC27", "aln": "MAVNPELAPFTLSRGIPSFDDQALSTIIQLQDCIQQAIQQLNYSTAEFLAELLYAECSILDKSSVYWSDAVYLYALSLFLNKSYHTAFQISKEFKEYHLGIAYIFGRCALQLSQGVNEAILTLLSIINVFSSNSSNTRINMVLNSNLVHIPDLATLNCLLGNLYMKLDHSKEGAFYHSEALAINPYLWESYEAICKMRATVDLKRVFFDIAGKKSNS-------HNNNAASSFPSTSLSHFEPRSQPS--------------------------LYSKT-------NKNGNNNINNNVNTLFQSSNSP----------PSTSASSFSSIQHFSR-------------------------------------------------SQQQQANTSIRTCQNKNTQTPKNPAINSKTSSALPNNISMN-------LVSPSSKQPTISSLAKVYNR--------NKLLTTPPSKLLNNDRNHQNNNNNNNNNNNNNNNNNNNNNNNNIINKTTFKTP-----------------RNLYSSTGRLTTSKK---------------NPRSLIISNSILTSDYSITLPEIMYNFALILRSSSQYNSFKAIRLFESQIPSHIKDTMPWCLVQLGKLHFEIINYDMSLKYFNRLKDLQPARVKDMEIFSTLLWHLHDKVKSSNLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEKATQLDPNFAYAYTLQGHEHSSNDSSDSAKTCYRKALACDPQHYNAYYGLGTSAMKLGQYEEALLYFEKARSINPVNVVLICCCGGSLEKLGYKEKALQYYELACHLQPTSSLSKYKMGQLLYSMTRYNVALQTFEELVKLVPDDATAHYLLGQTYRIVGRKKDAIKELTVAMNLDPKGNQ-VIIDELQKCHMQE------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .: :.:: : * **:* * :* : :::* * . : . . : *: : * :: .:*. :*.: .: : . .. : :.. . *:.:: : :: . .:: **::* .: :* : * * : . . . . . * : : .: *.: . * :..:. : . * . . .: . : .: *: . * .. . * .. :* . : .*:*:.. . ::* . : : . .: :. * :. : . . : : . : . * . : * :: :. ..::. **. :. :*.* .: * :* :*: :* : *. :: : *:. *:*:*: ****: .* * *::.* : ..* .** ** :***::*: *** * :* *:**.:.*:*** *** .:. :.* :* *: : :****:**:* * ::. * ::: ** .*** . *:: * : .: :*: : * ::*...* ::: ..: :: :*: **: :*** ::**.:: ..:*:*: :: :*. . *: .:: * :***** : * : ::. . ", "identical_positions": 120, "similar_positions": 241, "identity": "12.67%" }, { "cls_id": "homologset.agr.HGNC:17280", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B5DEH9-1", "uniprot_id": "B5DEH9_RAT", "id": "B5DEH9-1", "name": "Ankyrin repeat domain-containing protein 6", "aln": "--MSQQDAVAALSERLLIAAYKG-------------------QTENVVQLINKG---AKVAVTKHGRTPLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALDRQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRVLLLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLSAFCSVHEKNQAGDTALHVAAALNHKKVVKILLEAGADTTLVNNAGQTPLETARYHDNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPEKEEARRDCPPASQEPR-KDERRRKSRPEVSALSDPTPAADQQPGHQKNLHGHHHQKKKSRHRCWSPPPPHGFRAYQLYTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEAAVEELRAELGTVQDKVNTKLGHMESKSQHQMCVLDKLMVERLSAERTECLNRLQQHAAAEKQEGE-KRQMSLVDELKSWCMLKIQNLELRLSGE---SRTFRAKS-TPSPS----------DSSPAVDQPV-VAAGPGAASD-------------------SSSQ--------VVRPKDKALNATAVPRHQQELLPSDCTGSGLRKVKAP-------AASRLG---DQQTGSCVNRGTQTKKSARGGQTK-HRGQ-QPTASSPSGQQPSAASSD-----ARDASQALELTQYFFEAVSAQMEKWYERKIEEARSQASQKAQQDEATLKEHIRSLEEEVAKLRTKMHK--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q69ZU8-1", "uniprot_id": "ANKR6_MOUSE", "id": "Q69ZU8-1", "name": "Ankyrin repeat domain-containing protein 6", "aln": "--MSQQDAVAALSERLLIAAYKG-------------------QTENVVQLINKG---AKVAVTKHGRTPLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALDRQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRILLLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALNHKKVVKVLLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPR-KDERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPPPPHGFRAYQLYTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQMESKTQHQMCVLDKLMVERLSAERTECMNRLQQHAAAEKQEGE-KRQMSLVDELKAWCMLKIQSLELRLSGE---SRTFRAKS-TPPPS----------DSTPAVDQPV-VAAGPGAASD-------------------SSSQ--------VVRPKDKALNASAAHSHQQELPPSDCTGSGLRKIKAP-------GASRC----DQQTGSCVNRGTQTKKSGRSGQTK-HRGQ-QPTASSPSGQQPSAASSD-----VRDASQALELTQYFFEAVSAQMEKWYERKIEEARSQASQKAQQDEATLKEHIRSLEEELARLRTKVQK--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y2G4-2", "uniprot_id": "ANKR6_HUMAN", "id": "Q9Y2G4-2", "name": "Ankyrin repeat domain-containing protein 6", "aln": "--MSQQDAVAALSERLLVAAYKG-------------------QTENVVQLINKG---ARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGE-KRQISLVDELKTWCMLKIQNLEQKLSGD---SRACRAKS-TPSTC----------ESSTGVDQLV-VTAGPAAASD-------------------SSPP--------VVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARS----DQQAGPCVNRGTQTKKSGKSGPTR-HRAQ-QPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P2G9-1", "uniprot_id": "A0A8M9P2G9_DANRE", "id": "A0A8M9P2G9-1", "name": "", "aln": "MADSPHSSSSSSSPPFLLIAQFGSCLSNAPLSHAPVCGVLLISEENSSNSLREGEFTRISAAVQNGRTPLHLAAYKGHIAVVRILLAAGCDLDIEDDGDQTALHRAAVVGNTDVISALVQEGCALDRQDKDGNTALHEAAWHGFSQTVKLLVKAGANVHAKNKAGNTALHLACQNGHVQSCRVLLLGGSRPDSKNSVGDTCLHVSARYNHVSVIRALLGAICSVTDRNHTGDTALHIAASLNHRKTVRMLLEAGADSRIKNNTGETALDQARENNSPEVALLLTKAPQS--FSRGRTVRKRRDKMKTEGRAQSVPRDEMLPRKCDSAS---PAQDTHGSDGSLRRTDNMFLT-EPRANKNCHRKARDRLSPSDALIHRPNKQSDPKK-----KSKTERSSPSAIPPPPPHNYKAYQLYTLYRGKDGKIMQAPLNGCRCEPLISKLENQLMATKEEMQSEIHTVQELMNSKIGQMDRKSKHQIRALDKMTLERVSAERIECLHRIDKRAVQERLEAE-KRQTSVVKDLKNWCLSKIQSLETRLSGERVDSRLQRSSSLTDTLS----------DCTPVLEPSR-AAPHPSPSAE-------------------RTDAGE------TAAASSCAEDAPARYYVIEVDASADKPSSQNQSAPQSPCIVRPKQRSRACSDPHQLRDESEERSVEPRPAAEHRTIRRHRAKSKPSAQSLTLQTCPAAAEG-AFAQERDNMHALEVTQYFFEAVTLQMERWYERKIEETRRQADHRVQADRELLLDRIQHLEDELRLLRMNTQDG-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PES1-1", "uniprot_id": "A0A8M9PES1_DANRE", "id": "A0A8M9PES1-1", "name": "", "aln": "------------------------------------------------------------------------------------------------MGHQTALHRAAVVGNRDAVSALIHGGCALDLQDKEGNTALHEVSWHGFSACVKLLVKAGADVNLKNKVGNSPLHLACQNGHSQTAQVLLLGGCMPDSKNNAGETCLHFAARYNHLAIIKMLLGSFCSVTEKNQTGDTALHVAAALNHKKAVSLLLEAGADANIKNNTGQTALDKARDNNNRELAILLAKSNQVQRYARGKTVRKRRDVSRAQRKTQSLPRVHKPRKKDDSEAAEDSINSDQAFQRIQPEHRAATLSPDNRRKNTSPGRTPVLLREYDLYERGVK--------------PSSLSSPDQHQTP----AKAFQLYTLYRDTDGQIKQAPAKDCHCKPIIKALEKKLKATEMEMRTEIHTIQEEINCRLGRIEQKNKHQIKVLEKLTQERVSAERMECHYRINQRATLERMEGQRKQQAAASNAVKSWCMSKIEDLEVRMPET-QYYKLLRSPSADSELEGLPLLSLVSEESSSSLATYVNVLPTPGASHKSLEFEDTLGKRYLKIKQNGSSDDYHNITAQPMVKHKPLSRSLATADLQWQRSELQEAEISKHRSDKGHELCDSSTSSSRSTSSKTFNDSDSISRSAWKHSKHLKDRIKAHRAQTQQSTTVNTLEVFSQRPAEATFTQERANLHAVEVTQRFFETVSTQLERWYERKILETQRSAEHKALQDRSRLMEKISSLEEELRRLRTDHSTNT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.*******:**** : ::**:: ***** ***:*******.:***** .***:****:* :**.**:.*******.* *: ::***.*. .* **..*:****.:*****::::: ** ::*** ::*::******:**:***:*.. :*******: : **:*:*.*: ** ::. *:*:**:*: * ::**:::**:*: : : ::**:** . * . : . .. . : : * :. :: : . . .. . .* :*:*******. **:: *** :.*:*:*:*. **::* *: *:::*: ::*: :* ::*::: *.:**: .*:*: **:**** ** *::::: *: *.: *:* : . :* **: **:.** ::. : *: * :.:. : . . *..: . : . . : . .: : : * :. :* . . .*.. : : **.: : :: : . * :*:*:** ***:*: *:*:****** *:: .*.::. *. * ::* **:*: ** ", "identical_positions": 208, "similar_positions": 201, "identity": "26.0%" }, { "cls_id": "homologset.agr.HGNC:17281", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIA8-1", "uniprot_id": "GHITM_RAT", "id": "Q5XIA8-1", "name": "Growth hormone-inducible transmembrane protein", "aln": "-MLAARLVCLR-----TLPSRVFQPTFITKASPLVKNSITKNQWLLTP-----------------SREYATKTRIRTHRGKTGQELKEAALEPSLEKVFKIDQMGKWFVAGGAAVGLGALCYYGLGMSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSALALARSPALMNFMMTGSWMTIGATFAAMIGAGMLVQSISYEQSPGPKHLAWMLHSGVMGAVVAPLTILGGPLLLRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFASSLGSMFLPPTSVAGATLYSVAMYGGLVLFSMFLLYDTQKVVKRAEITPAYGAQKYDPINSMLTIYMDTLNIFMRVATMLATGSNRKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91VC9-1", "uniprot_id": "GHITM_MOUSE", "id": "Q91VC9-1", "name": "Growth hormone-inducible transmembrane protein", "aln": "-MLAARLVCLR-----TLPSRVFQPTFITKASPLVKNSITKNQWLVTP-----------------SREYATKTRIRTHRGKTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGMSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSALAVARTPALMNFMMTGSWVTIGATFAAMIGAGMLVHSISYEQSPGPKHLAWMLHSGVMGAVVAPLTILGGPLLLRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFASSLGSMFLPPTSVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEITPMYGAQKYDPINSMLTIYMDTLNIFMRVATMLATGSNRKK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3K2-1", "uniprot_id": "GHITM_HUMAN", "id": "Q9H3K2-1", "name": "Growth hormone-inducible transmembrane protein", "aln": "-MLAARLVCLR-----TLPSRVFHPAFT-KASPVVKNSITKNQWLLTP-----------------SREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGLSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSAIAISRTPVLMNFMMRGSWVTIGVTFAAMVGAGMLVRSIPYDQSPGPKHLAWLLHSGVMGAVVAPLTILGGPLLIRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFVSSLGSMFLPPTTVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEVSPMYGVQKYDPINSMLSIYMDTLNIFMRVATMLATGGNRKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VZ34-1", "uniprot_id": "Q9VZ34_DROME", "id": "Q9VZ34-1", "name": "Growth hormone-inducible transmembrane protein", "aln": "MLLRLALSTARPAGAIKILAQSPAQLFRANANPNLNLSTVRT----------------------YARR-VVRTREPVEE-MRAPSLKEKLMGPPSANAY---SMGKGAAAGAAAVGLGALCYYGVGLGKQTSIADNAIMWPQFVRDRIQSTYAFFGGSCVLTAAAAAATFRSHRLLELASRGGILATIASLALVIGSGAVARSIEYQPGLGAKHLAWAVHCAILGAVIAPICFMGGPILTRAALYTGGIVGGLSTIAACAPSDKFLYMGGPLAIGLGVVFASSLASMWLPPTTALGAGLASMSLYGGLVLFSGFLLYDTQRMVRRAEVYPQYSYTPYDPINASMSIYMDVLNIFIRIVTILSGGQRRK-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VIB2-1", "uniprot_id": "Q9VIB2_DROME", "id": "Q9VIB2-1", "name": "", "aln": "-MLLARLNHVLSGRPMRLLGQSGCPRLWSSAHAQMNSNSLRTPSLAQGKSVIPKRNMQELGMRKYSRESRDRDRSQLESRTRGPSLKERMMGPPSENAY---SMGKGAAAGAALMGLVGLCYYGLGLANQPSIYDHSMVWPQYVRDRIHATYAYFGASCGVTAASAVAFFQSDAMMALMTRSGWVASLVTLGLVMLSGSIAQGLEYQPGFGAKQLAWLVHCAVLGAVLAPMCLLGGPILTKALLYTSGIVGALSTVAACAPSEKFLHMGGPLAIGLGVVFASSLASMWLPPTTAVGAGLASMSLYGGLILFSGFLLYDTQRIVKSAELYPQYSKFPYDPINHALAIYMDALNIFIRIAIILAGDQKRKN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* * : .: : .* . :: . :. :*. : * . . .*** : *. : : .**: .**.* :** .*****:*:.:: . :::::***:*:***::** ::..* :** :* * :: :: : .. :: .::. :: :* :.:.: *: . *.*:*** :*..::***:**: ::***:* :* **.****.***:* ****:*** **.**.:***:**.***.**:****:. ** * *:::****:*** *******:::: **: * *. ***** ::****.****:*:. :*: . .** ", "identical_positions": 128, "similar_positions": 118, "identity": "34.69%" }, { "cls_id": "homologset.agr.HGNC:17282", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JIR4-1", "uniprot_id": "RIMS1_RAT", "id": "Q9JIR4-1", "name": "Regulating synaptic membrane exocytosis protein 1", "aln": "MSSAVGPRG-PRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPERDWRLHQQFESYKEQVRKIG-EEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNN-EDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQ--------PSQDGTLSDTATGAGSEVPREKKARLQERSRS--------------------------------------------------------------------------QTPLSTAAVSSQDTATPGAPLHRNKGAEPSQQALGPEQKQAS-RSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGIADERERKE-------RRETRRLEKGRSQDYSDRPEKRDNGRVAEDQKQRKEEEYQTRYRSDPNLARYPVKAPPEEQQMRMHARVSRARHERRHSDVALPHTEAAAAAPAEATAGKRAPATARVSPPESPRARAAA------------------------------------------------------------------------------------------------------------------AQPPTEHGPPPPRPAPGPAEPPEPRVPEPLRKQGRLDPGSAVLLRKAKREKAESMLRNDSLSSDQSESVRPSPPKPHRPKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDP---------------------------------------------------------------------------ATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRT------------TMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIG------------------------DIPRIPESSHPPLESS-SSSFESQKME---------------------RPSISVISPTSP----------------------------------------------------------------------------------------------------------------------------------GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSP------FMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVG-----------YRASARE-----SKATTLTVPEQQRTTH--------------------------------------------------------------HRSRSVSPHRG----------------------------------------------DDQGRPRSRLPNVPLQRSLDEIHPTRR----------------------SRSPTRHHDASRSPADHRSRHVESQYSSEPDSELLMLPRAKRGRS------------------------------------------------------------------------------------AESLHMT----------------------------------------------------------------SELQPSLDRARSASTNCLRPDTSL------------HSPERER----------------------------HSRKSERCSIQKQSRKGTASDADRVLPPCLS-------RRGYATPRATDQPVVRGKYPTRSRSSEHSSVRTLCSMHHLAPGGSAPPSPLLLTRTHRQGSPTQS----------------------------PPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKVKVHRFKQTTG---------------SGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSDSDVSDVSAISRASSTSRLS-------------------------------------------------------------------------------------------------------------------------------------------------------------STSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKSTSVSGEIYTLERND--GSQSDTAVGTVGAGGKKRRSSLSAKVVAIV---SRRSR-------------------------------------STSQLSQTESGHKKLK--STIQRSTETGMAAEMRK--MVRQPSRESTDGSINSYSSEGNLIFPGVR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGPDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDP--TLAPLTRRASQSSLESSSGPPCIRS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99NE5-1", "uniprot_id": "RIMS1_MOUSE", "id": "Q99NE5-1", "name": "Regulating synaptic membrane exocytosis protein 1", "aln": "MSSAVGPRG-PRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPDRNWRLHQQFESYKEQVRKIG-EEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNN-EDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQ--------PSQDGTLSDTATGAGSEVPREKKARLQERSRS--------------------------------------------------------------------------QTPLSTAAVSSQDTASHGAPLDRNKGAEPSQQALGPEQKQAS-RSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGTADERERKE-------RRETRRLEKGRSQDYPDRLEKREDGRVAEDEKQRKEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGVSTPEYTSCEDVELESESVSEKGDLD-YWLDP---------------------------------------------------------------------------ATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRT------------TMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIG------------------------DIPRIPESSHPPLESS-SSSFESQKME---------------------RPSISVISPTSP----------------------------------------------------------------------------------------------------------------------------------GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSP------FMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVG-----------YRASARE-----SKATTLTVPEQQRTTH--------------------------------------------------------------HRSRSVSPHRG----------------------------------------------DDQGRPRSRLPNVPLQRSLDEIHPTRR----------------------SRSPTRHHDASRSLADHRSRHAESQYSSEPDSELLMLPRAKRGRS------------------------------------------------------------------------------------AECLHMT----------------------------------------------------------------SELQPSLDRARSASTNCLRPDTSL------------HSPERERGRWSPSLARRRPASPRIQIQHASPENDRHSRKSERSSIQKQSRKGTASDADRVLPPCLS-------RRGYAIPRATDQPVIRGKHTTRSRSSEHSSIRTLCSMHHLAPGGSAPPSP-LLTRTHRQGSPTQS----------------------------PPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTG---------------SGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSDSDVSDVSAISRASSTSRLS-------------------------------------------------------------------------------------------------------------------------------------------------------------STSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKSTSVSGEIYTLEHND--GSQSDTAVGTVGAGGKKRRSSLSAKVVAIV---SRRSR-------------------------------------STSQLSQTESGHKKLK--STIQRSTETGMAAEMRK--MVRQPSRESTDGSINSYSSEGNLIFPGVR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGPDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDP--TLTPLTRRASQSSLESSSGPPCIRS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86UR5-1", "uniprot_id": "RIMS1_HUMAN", "id": "Q86UR5-1", "name": "Regulating synaptic membrane exocytosis protein 1", "aln": "MSSAVGPRG-PRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSP-----------------------RLHQQFESYKEQVRKIG-EEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNN-EDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQ--------TSQDGTLSDTATGAGSEVPREKKARLQERSRS--------------------------------------------------------------------------QTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKE-------RRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALP-EGKAGKRAPAAARASPPDSPRAYSAERTAE---------------------------------------------------------------------------------------------------------TRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDP---------------------------------------------------------------------------ATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRT------------TMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIG------------------------DIPRIPESSHPPLESS-SSSFESQKME---------------------RPSISVISPTSP----------------------------------------------------------------------------------------------------------------------------------GALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSP------FMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVG-----------YRSSARE-----SKSTTLTVPEQQRTTH--------------------------------------------------------------HRSRSVSPHRG----------------------------------------------NDQGKPRSRLPNVPLQRSLDEIHPTRR----------------------SRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRS------------------------------------------------------------------------------------AECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSL------------HSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLS-------RRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSP-LLTRMHRQRSPTQS----------------------------PPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTG---------------SGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLS-------------------------------------------------------------------------------------------------------------------------------------------------------------STSFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHND--GSQSDTAVGTVGAGGKKRRSSLSAKVVAIV---SRRSR-------------------------------------STSQLSQTESGHKKLK--STIQRSTETGMAAEMRK--MVRQPSRESTDGSINSYSSEGNLIFPGVR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDP--TLTPLTRRASQSSLESSTGPPCIRS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32SZR7-1", "uniprot_id": "A0AB32SZR7_DANRE", "id": "A0AB32SZR7-1", "name": "", "aln": "MSASVGPRGGPRPPTKQNSMPDLPDLSHLTEEERKIIMAVMARQKEEEAKDEAMLKEEKPIQAKTVNLVGNKKPPQQND--------------------------ISLHQQFANYKEQVRRTGPEPQQRQQGQHKDDAPTCGICHKTKFADGCGNLCSYCQTKFCARCGGRVSLRSNNKEDKVVMWVCNQCRRQQDMLTKSGDWFPSQVPKP--------GELGSAVSEPAMCG------DPSGDKKMRSRS--------------------------------------------------------------------------QNPLDSSISTAHITQTS-APTDPRKCP-----SAGPADTPSS-RSRSEPPQDRKKPPAASDQNGKPGPRGERRQRLSKIHS------EERDTGEN------RRESRKLMKTRSQEHDSPETRRTEGEQKPPREQCRTDPNAPHHPGKLRPTEPDGRLHPKSREGGDMVQDNRGARRWADGRQASLEGPQPTYVP-ERTAGETGLQGMPAMQGPTPKTNHTP-------------------------------------------------------------------------------------------------------------------QPPAPGFKLGPAMPTGPPELREPQEWDRKLQPSHLDPGSAALLRKSKRQKAESMLRNDSLSSDQSESLRPPPPRPYKSKRGGNKRQMSVSSSEEEAGSTPEYTSCEDVEIES--VSERGDWECCPLDP---------------------------------------------------------------------------TAWH---------HPVTWQPSKEGDHLIGRITLSKRT------------AMPKEAGALLGLKVVGGKVTETGRLGAFITKVKKGSLADVVGHLRAGDEVLQWNGKSLPGLTKKEVYNIILNSQAEPQVELIVSRPIG------------------------DIPRIPETSHPPLESTGSSSFESQKME---------------------RPSISVLSPSSP----------------------------------------------------------------------------------------------------------------------------------SGLRDAPQLLPGQLSVKMWYDKVGHQLIVNVLQAKDLPPRSDTRPRNPYVKMYFLPDRSDKSKRRTKTVKKSLEPKWNQTFVYSHVHRRDFREHMLEITVWDQPRIQEEESDFLGEILIELETALLDDKPHWYKLQTHDVSSIPLPHPSP------FLPRRHGHTETPTKKLQRSQRITETDY-----DDTIGVVATATE----------NRSRERERERDRDRATTLEVPDQQRPTQ--------------------------------------------------------------YRSRSVSPHRD----------------------------------------------EDRG--RSRPPNVPAQRSLDEVQHTRR----------------------SRSPTRYHD--------RNRLQERDYID--DSEVILIHRSMRGRS------------------------------------------------------------------------------------AECLHTQRSSSKYSSTLPPKMPLLVNGIHKDIYSSTLPACLKSKS-RLSVVTATHRTVTRRVLRFTDTICISDLQPSLDRVRSASTNCLRPDSNS------------NSPDRER--------------------------------------STQSLPRTRPMSPRILIQHAS-------PEDDSWVLEAMFPAQETLHHLSAKPDPQRQSRALDRPSCQKLGRKMSDSE----RVQPHSSPAFS----------------------------SSTAANSSARKVRQLPQVPAKSSSVEQA-LASEERTRQMKVRT--FRTPAP---------------SSTSQDLERALKNKRELYKEQRRSCDNVSHKSSDSDVSDVSAISRASSASRIS-------------------------------------------------------------------------------------------------------------------------------------------------------------STSYMSIQSERPRGRFS--------RHIRPSSRSMLKSTSVSGEIYTLERTD--GSQSDTALGTLGSEGKKRRSSLSARVVAIVGIPSRRSR-------------------------------------STSQLSQTEAANKKAKGSSQIQRSQETGMAVEYPRNVMARQASRESTDGSMNSYSSEGNLIFSGMR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGADSQFSDFLDGLGPAQLVGRQTLATPAMGDVQIGLMDKKGQLEVEVIRARGLTPKPGSKSLPAPYVKVYLLENGACKAKKKTKIARKTLDPLYQQSLLFEESPQGKVLQVIVWGDYGRMDHKCFMGVAQIFLEELDLSSTVIGWYKLFPPSSLVDP--TLAPLTRRASQTSLDSS-GPPGTRS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K6M2-1", "uniprot_id": "A0A0B4K6M2_DROME", "id": "A0A0B4K6M2-1", "name": "", "aln": "-------------------MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVT-------------------------------------------LEMQIRQRSEQQKKAG-----------VELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNK-----VIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYG--ANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDSLKL------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * ::******* .** * *: ***:** *:: ::: .. *. *: . .** :: * : .** ** ******* *::* **. : ******:*:****: *:*** **::*::*:*:* *: .: . .. :*: . . : ** : * * . . . . . . . . : : :*:*: :.::: *: : . : . :: . ::: : ::. : : :.*:: :: : . .:: : . * :*.... :* .:*: . :*. :: . :**.**.* :. :***:: * * * :*. :. .*. : * **:: ***:**:**: *::*.***:*:***: * . : .***:** :*: :.***:******* .:* .::: * .. ** * :. :**: : ** ** .. * : *:*.:*: **: ****.:: *..*. * . ****.*:::*****.********* . **:*.****** ::* *:. ::**:*:** * .:*:**::*:* :***:..**:**.*: :* * . .. : * * :. .:*. *: :: * . *. : . * *: : .: *. : *.. : **.**:*. : : .. * :*.* :: * * .* ** . : .* . **:: : * * :. : .:: ** . : *.. .* *.. . .. : *. : . : . . .*: . ..: : : . .* : *: : .* : : : . .. *:.*: . . : : * *:. .*.* .. .. * *.:: :* ::* **.. : : . *: .. : :..: ::.* * . .. *: * :* * : *.: ..: *: .. .::.: :*.* ** : :: : : : . * ::. . :.: :* .: *: :: * . . : *. :.:*:*****.******.*.:*::**:*:.: .:** *********.* *. ** *********:.. * * ** **:********.*:*.:* * :**: *******:::* *******:*::*:**. ******** .:***. .: :**:* :**:* ", "identical_positions": 363, "similar_positions": 416, "identity": "12.59%" }, { "cls_id": "homologset.agr.HGNC:17283", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9UQ26-6", "uniprot_id": "RIMS2_HUMAN", "id": "Q9UQ26-6", "name": "Regulating synaptic membrane exocytosis protein 2", "aln": "MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKK---------KVKEEHKPQLTQWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSN--------TPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRR------------SQHEP---QFYEDSDHLSYRDSNRRSHRHSKEYIVDDE----DVESRDEYERQR-REEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERR----------------------------HSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSS---------------------------------AVRKTKREKMETMLRNDSLSSDQSESVRPP----------------------------PPKPHKSKKGGKMRQISLSSSEEELASTP----------EYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKEMMYFGGHSLEEDLEWSEPQIK------------------------------------------------------------------------------------DSGVDTCSSTTLNEEHSHSD--KHPVTWQPSKDGDRLIGRILLNKRLK---------DGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIG----------DIPRIPDSTHAQLESSSSSFESQ------------------------------------KMDRPSISVTSPMSPGMLR--------------------------------------------------------------------DVPQFLSGQLS--------------------------------------------------------------IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMP----------------------------------------------------------RRQLHGESPTRR-----------------------------------------------LQRSKRISDSEVSDYDCDDGIG---------------------------------------------------------------------------------------------------------------------------------------------------------------VVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSVPPPQS---------------------------------------------------------------------------------------------------------------------------------------------------------------------RNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRD---------------------------------------------------------------------------------------------------------R-----------------------------------------------------DCEAADR--------------------QPYH---RSRSTEQR-----------------PLLERTTTRSRS---------TERPD--------TNLMRSMPSLMTGRSAPPSP-----------ALS------------RSHPRTGSVQTS-PSSTPVAGRRGRQLPQLPPKG-----TLDRKAGG--------KKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVR--------------------------------------------LASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDP--TLAPLTRRASQSSLESSTGPSYSRS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9EQZ7-1", "uniprot_id": "RIMS2_MOUSE", "id": "Q9EQZ7-1", "name": "Regulating synaptic membrane exocytosis protein 2", "aln": "MSAPLGPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKIKEEHKAQPTQWFPFSGITELVNNVLQPQQKQPNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSN--------TLQQPDQKVPRGLRNEEAPQEKKAKLHEQPQFQGAPGDLSVPAVEKGRAHGLTRQDTIKNGSGVKHQIASDMPSDRKRSPSVSRDQNRRYEQSEEREDYSQYVPSDGTMPRSPSDYADRR------------SQREP---QFYEEPGHLNYRDSNRRGHRHSKEYIVDDE----DVESRDEYERQR-REEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERR----------------------------HSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRTSNHSPPTPRRSPIPLDRPDMRRADSLRKQHHLDPSS---------------------------------AVRKTKREKMETMLRNDSLSSDQSESVRPP----------------------------PPRPHKSKKGGKMRQVSLSSSEEELASTP----------EYTSCDDVELESESVSEKGDSQKGKRKTSEQGVLSDSNTRSERQKKRMYYGGHSLEEDLEWSEPQIK------------------------------------------------------------------------------------DSGVDTCSSTTLNEEHSHSD--KHPVTWQPSKDGDRLIGRILLNKRLK---------DGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIG----------DIPRIPDSTHAQLESSSSSFESQ------------------------------------KMDRPSISVTSPMSPGMLR--------------------------------------------------------------------DVPQFLSGQLS--------------------------------------------------------------IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPRPSPYLP----------------------------------------------------------RRQLHGESPTRR-----------------------------------------------LQRSKRISDSEVSDYDCEDGVG---------------------------------------------------------------------------------------------------------------------------------------------------------------VVSDYRHNGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSAPPPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------RNVEQGHRGTR-ATGHYNTISRMDRHRVMDDHYSSDRD---------------------------------------------------------------------------------------------------------RSHPRTGSVQTSPSSTPGTGRRGRQLPQLPPKGTLE--------------RSAMDIEERNRQMKL--NKYKQVAGSDPRLEQDYHSKYRSGWDPHRGADTVSTKSSDSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKISVFTSKMQNRQMGVSGKNLTKST-----------SISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLSQTEGGG--------KKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVR--------------------------------------------LASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGRVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDP--TLAPLTRRASQSSLESSTGPSYSRS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9JIS1-1", "uniprot_id": "RIMS2_RAT", "id": "Q9JIS1-1", "name": "Regulating synaptic membrane exocytosis protein 2", "aln": "MSAPLGPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIIQAVMDRQKK----------------------------------------EEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSN--------TPQQPDQKALRGLRSEEAPQEKKAKLHEQTQFQGPPGDSSVPAVERGRAHGLTRQDSIKNGSGMKHQIASDMPSDRKRSPSVSRDQNRRYDQSEEREEYSQYVPSDSTMPRSPSDYADRR------------SQREP---QFYEEPDHLNYRDSNRRGHRHSKEYIVDDE----DVESRDEYERQR-REEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERR----------------------------HSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRTTNHSPPTPRRSPIPLDRPELRRADSLRKQHHLDPSS---------------------------------AVRKTKREKMETMLRNDSLSSDQSESVRPP----------------------------PPRPHKSKKGGKMRQVSLSSSEEELASTP----------EYTSCDDVEIESESVGEKGD------------------------------MEYSWLEHASWHSS-----------------------------------------------------------------------------------------------------EASPMS--LHPVTWQPSKDGDRLIGRILLNKRLK---------DGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIG----------DMPRIPDSTHAQLESSSSSFESQ------------------------------------KMDRPSISVTSPMSPGMLR--------------------------------------------------------------------DVPQFLSGQLSS----------------------------------------------QSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMP----------------------------------------------------------RRQLHGESPTRR-----------------------------------------------LQRSKRISDSEVSDYDCEDGVG---------------------------------------------------------------------------------------------------------------------------------------------------------------VVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSVPPPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------RNVEQGLRGTR-ATGHYNTISRMDRHRVMDDHYSSERDSHFLTLPRSRHRQ-----------------------TSEHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSSERADTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVTGRRGRQLPQLPPKGTLERMITEDMDSTRKRNSGAMDIEERNRQMKL--NKYKQVAGSDPRLEQDYHSKYRSGWDPHRGADTVSTKSSDSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKISVFTSKMQSRQMGVSGKSMAKST-----------SISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLSQTEGGG--------KKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVR--------------------------------------------LASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDP--TLAPLTRRASQSSLESSTGPSYSRS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0AC58HL81-1", "uniprot_id": "A0AC58HL81_DANRE", "id": "A0AC58HL81-1", "name": "", "aln": "MSAPAGPRSG----------PVLPEMPDLSHLTEEERKIILGVMDRQKK----------------------------------------EEEKEQSMLKKLHQQFEMYKDQVQKMGEEAQSGPEQKSDAPTCGICHKTKFADGCGHLCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFFSGPGG--------ALPAGASDPRR--RHEEAPQEKKAKLQEAPLLYQSSGD-------RSRAPGLPRQASLNNNSSLK---PNDPTSNRKRSPSATRDPNQKYNQREEKADRSQYAPGEGGMPRSPSDYGAGD------------RQWRGGCGRSYEDAEVARGAYRARRGGWHSQEEYPPEPGFLPDGPPLSEHELQRQRQEEYQNRYRSDPNLARYPVKPQPYEEQMRMHAEVSRFRHERR----------------------------HSDVSLAYTEMEEP-LGPLRGPHYSPG---------------------------SGQTHWRSNHSPPG--------------TDSAHRQQQLLDPVS---------------------------------AVRKSKREKMESMLRNDSLSSDQSESVRPP----------------------------PPKPHKTKRGGKMRQVSLSSSEEELATTP----------EYTSCEDVEIESESVSEKGDSQRGKRQTFEQS-----HTLSEGQKKMVRFGGHSWEEDAEWCEPQVK------------------------------------------------------------------------------------DSGVDTCSSTTLNEEHSHSE--KHPVTWQPSKDGDRLIGRILLNKRMK---------DGSVPRDSGALLGLKVVGGKMTESGRLCAFITKVRKGSLADTVGHLRPGDQVLEWNGRQLQGATFKEVYNIILESKPEPQVELVVSRPIG----------DIPRIPESTHAQLESSSSSFESQ------------------------------------KMERPSISVTSPMSPGVLR--------------------------------------------------------------------DAPQYLSGQLTS----------------------------------------------QSLSRRIEPFNPRVQVKLWYDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKSKRRTKTVKKSLEPKWNQTFMYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALVDDEPHWYKLQTHDVSSVPLPKSSPSLQ----------------------------------------------------------RRALHGDSPTRR-----------------------------------------------LQRSQRISDSEFSDYDCEDGVG---------------------------------------------------------------------------------------------------------------------------------------------------------------VVSDYRN-GRDLQSSTLSVPEQVLSSNHCSRSAD------INRARSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSMPPSQSHF----------------------------------------------------------------------------------------------------------------------------------------------------------LTLPRTRHSQPHDSDLQDLRNYGGAPDRHEYHHRSRSADQRAAMERPMYS--------------------------------------------------------------------RSRSTERPPDGPHMRSSMPSLPSGHSAPSSPALSRAHPRGGSVQTSPTGTPINSRRGRQLPQLPPKGTLER---KDGEEEVEACPGALDVEERTRQMKLKMNKYKQGTGSDSRLEQDYHK--RSGRDPQRG-ENLSAKSSDSDVSDVSAVSRTSSASRFSSMSYISVQSERPRG-------SRKIRQMGTAAGG-NMTKST-----------SIGGDMCSLEKTDGSQSDTAVSLVGTDDKKRRSSIGAKMAAVVGLSRKSRSASQLGQTEAGG--------KKLRSTIQRSTETGLAVEMRSRMTRQASRESTDGSMNSYSSEGNLIFPGVR--------------------------------------------LSSDSQFSDFLDGLGPAQLVGRQTLATPPMGDIQIGMVEKKGALEVEVIRARGLVGKPGSKALPAPYVKVYLLENGACIAKKKTKVARKTLDPLYQQQLSFEESPGGKVLQIIVWGDYGRMDHKSFMGAAQILLDDLDLSNMVIGWFKLFPPSSLVDP--TLAPLTRRASQTSLDSGSGP-FARS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K6M2-1", "uniprot_id": "A0A0B4K6M2_DROME", "id": "A0A0B4K6M2-1", "name": "", "aln": "----------------------MDEMPDLSHLTPHERMQIENVLMRQKQ----------------------------------------EEEKQNEIMRRKQDEVVTLEMQIRQRSE--QQKKAGVELDATCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYYDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYG--ANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDSLKL------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ********* .** * *: ***: :: :::. : :::. : *::: .* *. .** ** ******* ** * **: : ******:*:******:*** ****:**:*:*:* *: . . . : . . :*:.**.. . * :: . :. . . . * :: :: . : : : : . * : *** . * * :. :: *.:: : .: : *: :.::: * :.. : : *.*. *:: :.: *.:: :. . . ::.. . : : : . : * : .::. *.. . ::: :* : .: *. *. :* :*:. . . * : ** . * :**. :.* : * . ..: * :.. .* * .. : . . :**.**.* *. ****:::*.* . :*. * :*. :. .*. : .* *:: **::**:** *::****::****** *:. : .***:** **: :.****:****** ::. *. :: .. :* .: .* : ::**: :*** **.: ..* * * : :** :*: *****:: *..*. *:.* ****.*:::*****.*.******* .: **:*.***:** ::* ::. *:**:**** .* .:*:**::*:* ::***..**:**.*: :* * .. : ** :. ** * :. *:* .: ** ..*:* :* :. :: .* :. .* ** ..: * :. .*. :*: **.* . . . : .* * . : :. . * : .: : *:: : : . : . . .. :: :. . :. . *. . :.*. .. *: *. . *:. : :. :* : *.* *.:. *. : .: * .*. :.:*:*****.******.*.:*.:****:.: .:** ****:****** *. ** **********:.. *: * **. **:**:***** * *::* * :*** *******:::* ***.***:**:*:***:****:*** .:***. .:. :**:* :**:* . ", "identical_positions": 362, "similar_positions": 392, "identity": "12.61%" }, { "cls_id": "homologset.agr.HGNC:17284", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JX31-1", "uniprot_id": "A0A0G2JX31_RAT", "id": "A0A0G2JX31-1", "name": "Protection of telomeres protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------MSLVP-----VTPYTYTPLNLLKEGAVANVYGVVKFFKPPYLSKGTDYCSVVTIVDPTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINSSGFASLTFEGTLGTPVTARTSSKVFSFTSQDQKMVEALRVWASKHIAASSSLVQLCDAQPLQYYDLTCQLLGKAEVDGTAFLLKVWDGTRTMFPSWRVSIQNLTFEGDLSHIQRLQSLVIDILVYDNHVQVAKSLKIGSFIRIYSLHTKLQSVDSETSKS-LLRLEFHLHGGTSYGRGIRVLPDESSCVDQLKKDLEC-ADSAVTQPSNGICQSKNED-SFVLSSSASGSVSLYEEERCQQVSSTILTDHQHLEKTPLCAVLKQKAPQQYRVRAKLRSYLPRRLPQSVKLICPQCHSLQEVPHEDSLDKLLQDAATKAPDIRLQGTSLYESKIWTTEGQGGRQVAVHFVKKDGVLPLSSECLILIEGGRLCEVSKLSSKFHSVIPVRSGPEDLELLDISAPFLIQGKLHHYGCKQCSSLKPIQNLNSLLNKGPWIPSSVAKVLGIVPLQYVFVMTFTLDDGTGVLDTYLKD-SENFFKIPASEVLTDDNLQRNLEAIMDMICPPGIKVDAYPWLECLIKSYNVTIGTEQRICYQIFDTTVAEDV-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WC1-1", "uniprot_id": "POTE1_MOUSE", "id": "Q91WC1-1", "name": "Protection of telomeres protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------MSLVS-----TAPYTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGTDYCSVVTIVDQTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEG-ANLPVTETSTGICQSENGD-SSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKD-SEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NUX5-1", "uniprot_id": "POTE1_HUMAN", "id": "Q9NUX5-1", "name": "Protection of telomeres protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------MSLVP-----ATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSE--NQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLES-ANLTANQHSDVICQSEPDD-SFPSS----GSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTLDDGTGVLEAYLMD-SDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "H7BX60-1", "uniprot_id": "H7BX60_MOUSE", "id": "H7BX60-1", "name": "Protection of telomeres protein 1", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------MSSAP-----VAPSTYTPLNLLKEGTVVNVCGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCMLFSRDYDTLPSVYKVGDIVCFQGLKIQAYKNELQAISKFGFASLTFDGTLGAPIILRTLSKRFNFTAQDYSMVEALRTWASTHISASSNLVQLSDAQPMQYYDLTCQLLGKAQVDGVSFLLKVWDGTRTKIPSWRVCIQDVAFEGDLSHILQLQNLVVDIVVYDNHVQVAKSLKIGSFLRIYSLHTKLQPINSESTTS-LVRLEFHLHGGTSYGRGIRVLPESNYDVDQLKKALES-VDLEAIQTSDDTYQSDNVENCLTSSSSESDLVSLYEVERCQPLCATTLTGYHHLEKTSLCDILKQRAPRQYRIRAKLRSYKPRRLPQSVKLFCPKCHLLQEIPSEENVDKILQDATATAPDCKLQDTPLYDSEVWTTEGQGGRQVAVHFVKNDGVLPHSSECLVLIEGGRLCEISRLSSMFHSVIPVRSGPEDLELVDLAAPFLIRGKVCHYGCKQCSNLKTIQNLSIIPNKRLWIPSSVAEVLGIVPLQYVFVMTFMFDDGTGVLDVYLKD-SEKFFQIPASEVLTDDDLQRNLEQIMNVICPPGIKIDAHPWLECLIKSYNVTSGTEHQICYQIFDTMIAEDII", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "E7F0D5-1", "uniprot_id": "E7F0D5_DANRE", "id": "E7F0D5-1", "name": "Protection of telomeres protein 1", "aln": "MPVEKVNNSSDLDTKVPSCLQLTSIGQLTLTSDPSHRCVKARVLRKGPVISCAQRDGLEMLRAEIREEDPLQSTTEHTSINVIFFDTLAKDFSQSVKQGDIVLLANFTISKSPTFLRDKLHPCQLEMDNKDACVYVCPSAIPGPSSSEAKYVYVPLNKLKSKTLVNVYGVVTFFKQPFPSKGSDYCTTLKITDQSDVKVICTIFCKKLEDHPLIFRVGDIIRLHRFKAEAFRDSITLINTFGWSTVTFNGIIDSPIVPRTSSKSFFYGEADKRRVQELRQWAANQSLCSDLNTSLSSVQPHMYFDFTCQLLAKAVMHSGCILLKVWDGTRCQLPLLQVAVPPDELEGECTLAKDKMNLTANVLVYDNHLEVARDLKPGAFLRFYNLRALLQKVPGQLPDQ-PEHLGFHLHGGTVYGRGLRSLPAETPDLLSLKSVLEKHVDLDEHEEVNDGTLLEIWY-TPPESIVLPNDENPGAEENAGP-AYTVQTCEHNTQRITLAQVKRSTPPLSCHVRARVKKYLPQQLYQCLKLFCSKCKTMKDVPDDSAVANIFLESARDNQPCDEQ----WAATSSANSREPGRTISMHVSK-DMVGKSSHMQLIFIEGMTLDEISVLSRDHKNLVPVRSENSKMTRMDLTAPFLFSGKKRYYGCKQCS-RNTFENP-VFTGVETWDEQAVAAVLGVQMMQYRFLIQFELDDVTDTIEALLWEDAERFFHISAVDASGCQDLQDRIQTIMDTIQPPESSLEERPWMDFCLSVYTVKDNDRNKVCYQITNTEIVKQ--", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . : *.*** ** ::.** ***.*** *: ***:***:.:.*.* ::**: * :*. . : * ::: ***: :: :* :.::.. *. *::::**:* :. *: ** ** * : * *: ** **:.: * .*...** *:*:*****.** :.. .:********: :* :* :**: : .*. :::*****:.**:.:: *.*:*:*.*:: ** .: . * ******* ****:* ** . : .**. ** .: : . * . . *.. . * * : :: .*. : . .* . ::**:::.* *::* *.:** *.:*: ::::* : :: :.: : : : :.. : ** :::*. * : : * *::*** * *:. ** .:.::**** ..: : ::****: *. :******* ..::* * .:** .**: :** *:: * :** *..::. * : ::.**:*.* :. ::** :: **: : ** .:: **:: :. *.*. . .::**** :* :.:: ", "identical_positions": 188, "similar_positions": 212, "identity": "23.95%" }, { "cls_id": "homologset.agr.HGNC:17286", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0RDC9-1", "uniprot_id": "M0RDC9_RAT", "id": "M0RDC9-1", "name": "Exosome complex component CSL4", "aln": "MAPP---VRYCIPGERLCNLEEGSP----------------GSGTYTRHG----YIFSSLAGCLTKTSENGALP--------------------------------VVSVMR-------------ETESQLLPDVGAVVTCKVSSINSRFAKVHILYVG----------------------------------STPLKNAFRGTIRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHS----ESGVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DAA6-1", "uniprot_id": "EXOS1_MOUSE", "id": "Q9DAA6-1", "name": "Exosome complex component CSL4", "aln": "MAPP---VRYCIPGERLCNLEEGSP----------------GSGTYTRHG----YIFSSLAGCLMKTSENGAVP--------------------------------VVSVMR-------------ETESQLLPDVGAVVTCKVSSINSRFAKVHILYVG----------------------------------STPLKNAFRGTIRKEDIRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHS----ESGVQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y3B2-1", "uniprot_id": "EXOS1_HUMAN", "id": "Q9Y3B2-1", "name": "Exosome complex component CSL4", "aln": "MAPP---VRYCIPGERLCNLEEGSP----------------GSGTYTRHG----YIFSSLAGCLMKSSENGALP--------------------------------VVSVVR-------------ETESQLLPDVGAIVTCKVSSINSRFAKVHILYVG----------------------------------SMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHS----ESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B8A4H5-1", "uniprot_id": "B8A4H5_DANRE", "id": "B8A4H5-1", "name": "Exosome complex component CSL4", "aln": "MSP----MKLCVPGERLCSTEDCIP----------------GTGTYLRHG----YIFASLAGYVLRKNEGEELP--------------------------------VISVVR-------------ETEAQLLPDVGAIVTCKVTSINPRFAKVHILYVG----------------------------------STPLKDRFRGTIRREDVRATEKDKVETYKSFRPGDIVLAKVISLGDVQSNYLLTTAENELGVVVAHS----EAGAQMVPVSWCEMQCPRTHSKEFRKVARVQPEYLQA---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VKJ4-1", "uniprot_id": "Q9VKJ4_DROME", "id": "Q9VKJ4-1", "name": "", "aln": "MSEQQDETVVCLPGERLCRTEDSIVL---------------GIGTYEQNG----YIYASKSGIVNIEDSGDKCQ--------------------------------VVSVHK-------------PGFHLTIPATGDVVTARVLVTTPKFAKCAIFCVR----------------------------------NVLLESSYRGLLRKEDVRETEKDRVDIYKSFRPGDVILARVIN--QLEQSFLLTTAENELGVVIAYASDYRKTRVPMVPVGWSEMQCPQTTIKEPRKVAKVLPESSINAVK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53859-1", "uniprot_id": "CSL4_YEAST", "id": "P53859-1", "name": "Exosome complex component CSL4", "aln": "MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLIQYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRTVKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVEDKPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRVKVIECFKPGDIVRAQVLSLGDGTN-YYLTTARNDLGVVFARAAN--GAGGLMYATDWQMMTSPVTGATEKRKCAKPF---------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: . **: :* * ::* * :: * : .. ::** :* * :* :* . : *: *: * . * . :** :* :*:* *::*:*. :.*:***:: *:*:. : . : ****.*:****.* : : * . .* * .* * .* ** *: ", "identical_positions": 51, "similar_positions": 51, "identity": "16.78%" }, { "cls_id": "homologset.agr.HGNC:17287", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LW82-1", "uniprot_id": "A0ABK0LW82_RAT", "id": "A0ABK0LW82-1", "name": "Histone-lysine N-methyltransferase", "aln": "MAAARAKARSGEARARCHRAPGPPQRPKPRRTTRRCRADTVTARRSRSSAGGRRAGSNRARSRAPRAAVFGGECARGASFKEFSGLCMLKIYFPMRKINEAKISAVFQNGKAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKGVEYYLVKWKGWPDSTNTWEPLWNLRCPQLLQQFSDDKNTYLSQGRKRKAITSKDNNKSLQPAVAEYIVQKARQRIALQRWQDYLNRRKNHKGMIFVENTVDLEGPPSDFYYINEYRPAPGITLNSEATFGCSCTNCFFEKCCPAEAGVVLAYNKNRQIKIQPGTPIYECNSRCRCGPDCPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQLYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGELSSDSIDYSPARKRVRTQCKCGAETCRGYLN", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EQQ0-1", "uniprot_id": "SUV92_MOUSE", "id": "Q9EQQ0-1", "name": "Histone-lysine N-methyltransferase SUV39H2", "aln": "MATARAKARGSEAGARCHRAPGPPPRPKARRTARRRRAETLTARRSRPSAGERRAGSQRAWSGAPRAAVFGDECARGALF------------------------------KAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVAKGVEYYLVKWKGWPDSTNTWEPLRNLRCPQLLRQFSDDKKTYLAQERKCKAVNSK----SLQPAIAEYIVQKAKQRIALQRWQDYLNRRKNHKGMIFVENTVDLEGPPLDFYYINEYRPAPGISINSEATFGCSCTDCFFDKCCPAEAGVVLAYNKKQQIKIQPGTPIYECNSRCRCGPECPNRIVQKGTQYSLCIFKTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQCKCGAETCRGYLN", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H5I1-1", "uniprot_id": "SUV92_HUMAN", "id": "Q9H5I1-1", "name": "Histone-lysine N-methyltransferase SUV39H2", "aln": "MAAVGAEARG-----------------------------------------------------------------------------------------------------AWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:. *:**. ***********************************************.*.:******************** **:** **:***:**:.**:* :* **:..* :*:**:*****:**:********** *********************** ********:*****:: .*********:***:*********:*****::**** ************:***:*****************:**** **********************************:********************************************.*********************:***************: ******:***:***** ***** *******", "identical_positions": 353, "similar_positions": 40, "identity": "69.08%" }, { "cls_id": "homologset.agr.HGNC:17288", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QUH3-1", "uniprot_id": "APOA5_RAT", "id": "Q9QUH3-1", "name": "Apolipoprotein A-V", "aln": "---MAAVITWALALLSVFATVQARKSFWEYFGQNSQGKGMMGQ--QQKLAQE--SLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQ-NNPEGHSG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8C7G5-1", "uniprot_id": "APOA5_MOUSE", "id": "Q8C7G5-1", "name": "Apolipoprotein A-V", "aln": "---MAAVITWALALLAVFASTQARKSLWDYFSQNSWSKGVMGQ--PQKLAQE--NLKGSFEQDLYNMNNYLEKLGPLRGPGKEPPLLAQDPEGIRKQLQQELGEVSSRLEPYMAAKHQQVGWNLEGLRQQLKPYTAELMEQVGLSVQELQEQLRVVGEDTKAQLLGGVDEALNLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAAASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSAFIRVSTDGAEDGDSLDPQALSEEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLQDQGHSHLSDPEGHSG", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6Q788-1", "uniprot_id": "APOA5_HUMAN", "id": "Q6Q788-1", "name": "Apolipoprotein A-V", "aln": "MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLS--GSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSR--AFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58HH61-1", "uniprot_id": "A0AC58HH61_DANRE", "id": "A0AC58HH61-1", "name": "", "aln": "-------------MMWISDSTALPTGLWVSTTAVT-SPCYINIDWNYSPSHLFLNRTASIKAKQHRLAASVNIMKVLVVFALAVFTGCQANLFYADEPKPQLEQLTDAFWSYVSKATQTAEETVKMIRE--SQLGQEVNERLTQSADMASEYAVVLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEPYADNMKSQIQQRVEELRAAMAPYADSLDS------ETLKATLLQKSEELRGNLEQSVKELQVQLEPY---------------TAELKEKVDQHLQEFQKTVTPLTEDLQVQIRERAQMVQQSLTP-------YAEDLKE-KLDPYAQNLKDQLASLYESYTKRN----------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1N5N8-1", "uniprot_id": "A0A8M1N5N8_DANRE", "id": "A0A8M1N5N8-1", "name": "Apolipoprotein A-IV", "aln": "-------------------------------------------------------------------------MKVLVVFVIAAFSSCHANMMWQDQPMPSMDLVKNAFWNYVSQATLTAEETLQMIRN--SELGQEINDRISKSTDAINKYTLAIQSQVTPLTQELLTKLSQEADQLKLSLEQEITSAQTQLKPYVEELKVDIEEQIERLKKDVAPYAEALNP------EAMRLTLVLRAEELKAKLETSLMAMGPQSE-------------------ELKQKLEQHFVEFQMSMSPLAESFQSQLAQRSQELQKNLAP-------YSEELS--KLDPLAQDLKDQLTALWESFAKDKQS--------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : : .: :. : *:: . .:: :*: . :: ::: .: .: : . . . : : : :: : :. : :.**.: : * .:::.*: :**:* : . :.: .* ::: *: :: .: : : . *.::: *:: *: : : :.:: :*:.*:* :: :: . . . *: :* *:*. : ", "identical_positions": 22, "similar_positions": 98, "identity": "5.87%" }, { "cls_id": "homologset.agr.HGNC:17289", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BYZ7-1", "uniprot_id": "ELMO3_MOUSE", "id": "Q8BYZ7-1", "name": "Engulfment and cell motility protein 3", "aln": "MAPPR------NVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDAWSLTHPEHYALQFADG-HRKYITENNRLEIKNGSILCLSTAPDLKAQQLLGRLQNTSREGCCEVLRNLVLLASDMTFAQEVISRDGLQKLSTIIENGDDL-GEMLALGLRAFLELMEHGVVSWETLSISFVRKVISYVN-MNLMDASVQPLALRLLESVTLSSPALGQLVKSEVPLDRLLVHLQV---------MNHQLQTKAMALLTALLQGASPT-ERKEMLDHLWKKNLRQFIYKNIIHSATPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQRDQLQALRQAAFEPEGESLGTGLSADRRRS-------LCVREFRKLGFSN-SNPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTALLCELLRVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEG--TLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISS-RRRQDKLWFCCLSPNHKVLQYGDVEEGAKPPTLESLPEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSAL--LGSTMGSELTRLDLEQLLTMETKLRLLELENVPIPEQPPPVPPPPTNFNFCYDYSITEP--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q499U2-1", "uniprot_id": "ELMO3_RAT", "id": "Q499U2-1", "name": "Engulfment and cell motility protein 3", "aln": "MAPPR------NVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDTWSLTHPEHYALQFADG-HRKYITENNRSEIKNGSILCLSTAPDLKAQQLLSRLQNASREGCCEVLRNLVPLASDMTFAQEVISRDGLQKLSTIIENGDDL-GEMLALGLRAFLELMEHGVVSWETLSISFVRKVVSYVN-MNLMDASVQPLALRLLESVTLSSPTLGQLVKSEVPLDRLLVHLQV---------MNQQLQTKAMALLTALLQGASPA-ERKDMLDCLWKKNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPDGESLGTGLSADRRRS-------LCVREFRKLGFSN-SSPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCELLHVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEG--TLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISS-RRRQDKLWFCCLSPNHKVLQYGDVEEGANPPTLESLTEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSAL--LGSTMGSEQTRLDLEQLLTMETKLRLLELENVPIPEHPPPVPPPPTNFNFCYDYSMTEP--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96BJ8-1", "uniprot_id": "ELMO3_HUMAN", "id": "Q96BJ8-1", "name": "Engulfment and cell motility protein 3", "aln": "MAPPR------NVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADG-HRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDL-GEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVN-MNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQV---------MNQQLQTKAMALLTALLQGASPV-ERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRS-------LCAREFRKLGFSN-SNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEG--TLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISS-RRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSAL--LGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z4G1-1", "uniprot_id": "A0A8M6Z4G1_DANRE", "id": "A0A8M6Z4G1-1", "name": "", "aln": "MPQQK------DIVKIAIQMPGAYPQLIQLDQKKPLTSVIKEVCDKWNLPGPENYALQYADG-IQTYITESNRLDIKNGSILRLTKAPGRCAEDLYKGIQSSDSNVRCDSLNLLAIVSTDITFAQEFISRDGHSLLVKIVEDAQES-PVIMTHTLTAFMELMDHGIVSWENLSSVFIKKMASFVN-AKVLDTSIQQVSLAILESMVLSSSSLFTEVKQEITLERLLSHLQVYVDYTIHTRTNQQLQTKAMALLMALLQAGGEA-DRQELFEFLEKRNLRQYIHKNIIHSSSSVGDEMAHYLYVLQTVRLNHLEPRMKTPLDSYSQEQREMLHGLRQAAFETESES---GLSNERRRS-------LCAKEFKKLGFSNNSNPGQDLSRCPPGLLALDTMAYFASRYPDAYSRFVLENSSREDKHECPFARSSIQLTLILCEILRIGEPPSETGSDYHPIFFAQDRLLEELFCICIQLLNKTWKEMRATQEDFDKVMQVVREQITRTLASKPTSLELFKNKVNALNYSEILKLRQTERLHQEE--TLAPPVLELKERLKPELLELIRQQRLNRLCHGTLFRKMSS-RRRQDKLWYCRLSPNHKVLHYGDVEEETEMPSIEALQDKIPVADIKNVVTGKDCPHMKEN-KGKQTKEVLDLAFSITYD--VEEYSLNFIASSRTDFCLWTDGLSVL--LGKEMSSESMRSELEILLSMEIKLRLLDLENVPIPDAAPPIPKPPSNFNFCYDFSQTEQ--------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VKB2-1", "uniprot_id": "Q9VKB2_DROME", "id": "Q9VKB2-1", "name": "", "aln": "MIPKKTTVKDSHIVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIKNGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIEDGGQTNEDILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGESALSNLENIVMCSN-KHVLVAEDIKLQDILRLLQD--------VNSPVMRQNAIALLNALFVKADEG-RRRTIAQTISAKQFRLALIG------NGLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKELRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQYYKKLGFKCDINPAQDFIETPPGILALDCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFFTHDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTYQQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDKFWYARLSPNHKVIHYGDCDEKT-IPTMEELPKKLPISEIKQLLEGKECPHMKET---RIRKSAVNLAFSITFEN-MEHSTLDFVAPDESIFNYWTDGINAL--LGQPMVSKQKNEDFDTLLSMEIKLRLLDTEGVDISKDPPPIPEDPENYDFCFES-------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q07799-1", "uniprot_id": "LMO1_YEAST", "id": "Q07799-1", "name": "ELMO family protein LMO1", "aln": "MKHNR---------QMPDESLENIKVLLNPKLGKPVKSLTSAQSKACYHTLISNKNLNKTSDEYEKLLAN--YILLCDEKYLCKTVIPD---SRFWAILCDNCQKLRSETL--VANLIRIFNVALKCQDSNKNEVIVSICHISREN-----SQLIGILLQLLSQRPIHIPLFTDTILCITLFLKCSLTLCETSLSHAVEFVPRILILLFQYNFPASMSELLYIEDLQPLIL--------EEFVPLKQRLINFLSSVSIDDYSCSLKADLLTAIKDNSVFQKGLEMEMGDLPSINLLNAYDTFTFLNSPNGSFKRLYTEQLLFGEND-----FPLYEAIFKLSDQFRRLFNLSGKKEN-------------------QYSDSERDLKLQIATAVLNRQTCFYKT--LELFLRFWIESLAKSQSDLVSLLNLAIITLKYVCLSSSDLEAAIQTKSLLKTQVVALDS-MRYKFARTLQLDSIKKEQYRTWSSSIASFDTMLSGQVR-----------------DYVRHQRLLQLQKGTWVYAEN--PLNP------EAGTPKVYFLIVSDNHANLLAREFETQTND----------LPYLFDNKILTSPGSEALANGRTKVVVLKHITSFKSIELTT----PSRRTSSNVYIKLDEANVYTGVELKDRNDRTVLKFYLDTEEGRYIWLDGLKLISPFQHEDISEDTKEQIDTLFDLRKNVQMINLNVRQDIIVPPPEPSDEDEDEEFYNLETLKKVTQNFYFD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* : ::. : *:: . :*: : . .. . .. *: . . ::: : : . * *. : . : * :. : .* : . . . : .: . . : : : :*:.: : :: :. . : : .:: * * :: . : :* :: : : : ... :. :: :.: . :: : .:: * . *. . : :: . .. :*: . : :: . : :: *. .: :.. .: . :* :* *. : . .. * :. *. : . . :: *: ..: . :: *: : : .: *:: * . . * .*:: ** .:. * : ::*:: . : : : : .::. . : * : . . :: .: . :. *.* . * **:. : : *: . ::: *: :. :::::: : .** * : : :: ", "identical_positions": 42, "similar_positions": 205, "identity": "5.53%" }, { "cls_id": "homologset.agr.HGNC:1729", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P24788-1", "uniprot_id": "CD11B_MOUSE", "id": "P24788-1", "name": "Cyclin-dependent kinase 11B", "aln": "--MGDEKDSWKVKTLDEILQEKKRRKEQEE-----------------KAEIKRLKNSDDRDSKRDSLEEGE-------LRDHRMEITIRNSPYR---REDSMEDRGEEDDSLA------IKPPQQMSR--------KEKAHHRKDEKRKEKRRHRSHSAEGG-KHARVK--EKEREHERRKRHREEQDKARREWERQKRREMAREHS--RRER-------DRLEQLERK----RERERKLREQ-----------------QKEQREQKERERRAEERRKEREARREVSAHHRTMR--EEYSDKGKVGHWSRSPLRPPR--------ERFEMGDNRKP---------------VKEEKVEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPESRFDRD----SGDSEEGEEEVGEG-----TPQS---SAPTEGDYVP-DSPALSPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMT-----FSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNQGASAAGPGFSLKF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P21127-1", "uniprot_id": "CD11B_HUMAN", "id": "P21127-1", "name": "Cyclin-dependent kinase 11B", "aln": "--MGDEKDSWKVKTLDEILQEKKRRKEQEE-----------------KAEIKRLKNSDDRDSKRDSLEEGE-------LRDHRMEITIRNSPYR---REDSMEDRGEEDDSLA------IKPPQQMSR--------KEKAHHRKDEKRKEKRRHRSHSAEGG-KHARVK--EKEREHERRKRHREEQDKARREWERQKRREMAREHS--RRER-------DRLEQLERK----RERERKMREQ-----------------QKEQREQKERERRAEERRKEREARREVSAHHRTMR--EDYSDKVKASHWSRSPPRPPR--------ERFELGDGRKPGEARPAPAQ--KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE-GSTSEESEEEEEEEEEEEEE-TGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD----SGESEEAEEEVGEG-----TPQS---SALTEGDYVP-DSPALSPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMT-----FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNQGASAAGPGFSLKF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3BC62-1", "uniprot_id": "A0A8M3BC62_DANRE", "id": "A0A8M3BC62-1", "name": "Galactosyltransferase-associated protein kinase p58/GTA", "aln": "--MGDEKETWKVKTLDEILQEKKRRRELEE-----------------KSDPKRIKNADDRELKRDTPEEGE-------LRDHRMEITIRNSPYT---REDSTEDRGEEDESLA------IKPPQQMTR--------KDKNYHRKEEKRKDKRRRRSHSAEGAEKHPRTKDKEKERENERRKRQWHEDNKARQDYERQKRRDQARAHS--RRERSDTLTQRDRLEQLERK----RERDRKLREQE----------------QREQRELEERERRAKERRKDRDTRRDVPISHHRVAPAEEYTDKARLRHRSRSRSRSPVRL------QRETKAESSEPRR------------AVREGKVD-KDPLSDLQDISDSERKTSSP-GSSLGSGSGSEAEEDEDNEEEESSSQTEGDEEGESGSESEGSEHSGGALSDEEPSE-----EEEEGEEEEERENGNHIPPVPESRFDHDSEVSAEEEEEEEEEVEEEEAVDVTPQSHAPSATPEERYIP-ESPPVSPVELKKE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLRGVRHLHDNWILHRDLKTSNLLLSHKGILKIGDFGLAREYGSPLKPYTPVVVTLWYRSPDLLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKIFKDLGSPSEKIWPGYSELPAVKKMT-----FTEYPYNNLRKRFGALLSDQGFDLMNKFLTYCPAKRISADEALKHEYFRESPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRAPEGGQDFSQLGDDD---------------------------LKDTGFHLTT-ANKGASMAGPGFSLKF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P46892-1", "uniprot_id": "CD11B_RAT", "id": "P46892-1", "name": "Cyclin-dependent kinase 11B", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSEKS----RTTSWLFQSH----------------------EVTEILGRVKKNRKK----------------------LVKGLHRAGPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEKNYLP-DSPALSPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPLTSIREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLTHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDIGTPSEKIWPGYSELPAVKKMT-----FSELPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QCVKRGTSPKPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNDGAVSCRPWCSLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VPC0-1", "uniprot_id": "KP58_DROME", "id": "Q9VPC0-1", "name": "Serine/threonine-protein kinase PITSLRE", "aln": "MVNSSGSEDGQLRSPNDVHYHSRGEEDEHEGDADALYIQPPQASRESGSGPRREKKKHSRERRRHKERDDVGGAALALERDHRYDYRSREEHYHHHQRERSSNAAAAYAKHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKERERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDDIEVIRDDDDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQEQPEEKPEEKLKEKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPGFSLKF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : . .:. : . * : ..: : : .* :. :.* .* * :* **:* *.:*****************************:*:******************:**:*****:**.********************:***:************** *.*:***** * *** .* *******************:* ****:************:* **.:*******:*:*** : ***. *:*******.*:* *******:**::*::**::*:*.*******.:*****:* *:* * .:***:* *: *:.*:: :*** * :*:.*: .*** :*:* ***************** :.:**:.*.** :.*** *: .*** *.: .. * ** *", "identical_positions": 261, "similar_positions": 92, "identity": "27.42%" }, { "cls_id": "homologset.agr.HGNC:17290", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O70394-1", "uniprot_id": "I27RA_MOUSE", "id": "O70394-1", "name": "Interleukin-27 receptor subunit alpha", "aln": "MNRLR-----VARLTPLELLLSLMSLLLGTRPHGSPGPLQCYSVGPLGILNCSWEPLGDLETPPVLYHQSQKYHPNRVWEVKVPSKQSWVTIPREQFTMADKLLIWGTQKGRPLWSSVSVNLETQMKPDTPQIFSQVDISEEATLEATVQWAPPVWPPQKVLICQFRYKECQAETWTRLEPQLKTDGLTPVEMQNLEPGTCYQVSGRCQVENG-YPWGEWSSPLSFQTPFLDPEDVWVSGTVCETSGKRAALLVWKDPRPCVQVTYTVWFGAGDITTTQEEVPCCKSPVPAWMEWAVVSPGNSTSWVPPTNLSLVCLAPESAPCDVGVSSADGSPGIKVTWKQGTRKPLEYVVDWAQDGDSLDKLNWTRLPPGNLSTLLPGEFKGGVPYRITVTAVYSGGLAAAPSVWGFREELVPLAGPAVWRLPDDPPGTPVVAWGEVPRHQLRGQATHYTFCIQSRGLSTVCRNVSSQTQTATLPNLHLGSFKLWVTVSTVAGQGPPGPNLSLHLPDNRIRWKALPWFLSLWGLLLMGCGLSLASTRCLQARCLHWRHKLLPQWIWERVPDPANSNSGQPYIKEVSLPQPPKDGPILEVEEVELQPVVESPK---ASAPIYSGYEKHFLPTPEELGLLV-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A6K5-1", "uniprot_id": "D4A6K5_RAT", "id": "D4A6K5-1", "name": "Interleukin-27 receptor subunit alpha", "aln": "MSWLR-----VARLKPLELLLPLLPLLLGTRPHGSPGPLQCYSVGPLGILNCSWEPLGDLETPPVLYHQSQKYHPNRTKEVKVPSRQSWVTIPRKQFTTADELLIWGTQEGQLLWPPVSVNLETQMKPDTPQIFSDVDFFKEETLEAIVQWEPPKWPLHKVLICQFRYKKCQTKEWTQLEPQLKTDLMTPIEMQNLEPGTGYQVSGRCQVENG-YPWGEWSPDLSFPTPFLAPEDVWVSGTICETSGKPAALLFWKDPGPCVQVTYTVWLGVGDVTTTQEEVPCCKSPIPAQIEWAVVSTGNQTSWMPLTNLSLVCLAPESAPCDVRVSSTDGSPGIKVTWKQETGKPWAYVVDWAQDGDSLDKLNWTRLPPENLSTLLSGDFQAGVPYRITVTSVYSGGLAAAPSVWGFIKELAPLAGPAVWRLPDDPTGTPVVAWGEVPRHQLRGQATHYTFCRQSRGIPTICMNVSSQTKTVTLPNLYSGPFKLWVMVSTAAGQGPPGPSLSLHIPDNRIRWKFLPWVLSLWGLLLVGCGLSLAPP-----RCLYQRHKLLPQWIWERVPDPANSNSGQPYIK-VSLPQPPKDGPILEVEEMELQPVTESPK---ASVPLYSGYEKHFLPTPEELGLLRPPAPRVLDCSASG", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6UWB1-1", "uniprot_id": "I27RA_HUMAN", "id": "Q6UWB1-1", "name": "Interleukin-27 receptor subunit alpha", "aln": "MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSG----RCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA-----", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* * : * * ** * *: ***:**.******.***** *********** :*. *: *****:.*:. * *.: :***:***:*:* :*:**:***: *: **..* *********::*:: .:**: :: .*** *:* ** ** :*******:*:.** ** ***:*** :**:*:*:** .* *:* ***::*: *****. *** ** *:******.:* *.* .**.** * *****:*.**: .*. : * :.** * :*: *** **. * *** * ******** . *** .* *** **. : ***: . :* :*****:***.*:****.**** ***:**.*:* *********:* :.***:*.***** :**.**.**::*** * *.***.:************: ****:* ** .::* ***.:*::.***:* *. :*** .** ******** * **:*** :*** ** .* ****:*:*******.. ** : ***:**:*:**:*******.****::: *. .** * *******:* ** **.: *:.*: ***************** ", "identical_positions": 364, "similar_positions": 134, "identity": "56.43%" }, { "cls_id": "homologset.agr.HGNC:17291", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5BK85-1", "uniprot_id": "TMED1_RAT", "id": "Q5BK85-1", "name": "Transmembrane emp24 domain-containing protein 1", "aln": "MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPAN-ASLETEYQVIGG--AGLDVDFTLESPQ--GVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEE-VEGWAEAVEPE-----EMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKCPVPT-------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3V009-1", "uniprot_id": "TMED1_MOUSE", "id": "Q3V009-1", "name": "Transmembrane emp24 domain-containing protein 1", "aln": "MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPAN-ASLETEYQVIGG--AGLDVDFTLESPQ--GVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEE-VEGWAEAVEPE-----EMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKRPVPT-------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13445-1", "uniprot_id": "TMED1_HUMAN", "id": "Q13445-1", "name": "Transmembrane emp24 domain-containing protein 1", "aln": "MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPAN-ASLETEYQVIGG--AGLDVDFTLESPQ--GVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEE-VEGWAEAVEPE-----EMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VXY9-1", "uniprot_id": "Q9VXY9_DROME", "id": "Q9VXY9-1", "name": "", "aln": "MQAIWLGMPGLVLLLSIAALLLGVQDAEAYDKEMTVYVDAGKTECLYHSVRQG-ETIDFEYQVIDGGHGDLDISFTLLDPI--GLVIVSDFKKPENVHRHEVAKEGDYRFCFDNSFSMFNRKTVFFELIVEREGEELQGDTQWNEADELTGLSRDEYYDMKVQDIMDFIGRIRLQLTKARQLQDVLRSHEARDRNLAESNFQKVNHWSMVQISAMIGVGLIQVFMLRSIFATGGRMHNLWRKLGI", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8INX8-1", "uniprot_id": "Q8INX8_DROME", "id": "Q8INX8-1", "name": "GOLD domain-containing protein", "aln": "MFRIARVIWLLQLLLLLDLKFSNAEP---HNKQLTVFAEAGRQECFYQPIATT-ENIKIDYQVIHGGLGETHINFNLMDPS--RRLLIAETKRQMGKHSIQANETGSYKFCFDNTISTFNQKIVSFTLEVAPADREERELRDLRQEMLTD-----YHFDVAYTGIDSYVGKIHVNLMRSRQTQDFIRAIEARDRNVAESTYSMVNKWSWAQFLSMIFVGFLQVLMVRSIFNTTGTFYKFWKSF--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39704-1", "uniprot_id": "ERP2_YEAST", "id": "P39704-1", "name": "Protein ERP2", "aln": "--MIKSTIALPSFFIVLILALVNSVAASSSYAPVAISLPAFSKECLYYDMVTEDDSLAVGYQVLTG--GNFEIDFDITAPD--GSVITSEKQKKYSDFLLKSFGVGKYTFCFSNNYGTA-LKKVEITLEKEKTLTDEHEADVNNDDIIAN----------------NAVEEIDRNLNKITKTLNYLRAREWRNMSTVNSTESRLTWLSILIIIIIAVISIAQVLLIQFLFTGRQKNYV-------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q12450-1", "uniprot_id": "ERP4_YEAST", "id": "Q12450-1", "name": "Protein ERP4", "aln": "-------MRVFTLIAILFSSSLLTHAFSSNYAPVGISLPAFTKECLYYDLSSDKDVLVVSYQVLTG--GNFEIDFDITAPD--GSVIVTERQKKHSDFLLKSFGIGKYTFCLSNNYGTS-PKKVEITLEKEKEIVSSHES---KEDIIAN----------------NAIEEIDRNLNKITKTMDYLRAREWRNMYTVSSTESRLTWLSLLIMGVMVGISIVQALIIQFFFTSRQKNYV-------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q12403-1", "uniprot_id": "ERP3_YEAST", "id": "Q12403-1", "name": "Protein ERP3", "aln": "----------MSNLCVLFFQFFFLAQFFAEASPLTFELNKGRKECLYTLTPEIDCTISYYFAVQQGESNDFDVNYEIFAPDDKNKPIIERSGERQGEWSFIGQHKGEYAICFYGGKAHDKIVDLDFKYNCERQDDIRNERRKARKAQRNLR---DSKTDPLQDSVENSIDTIERQLHVLERNIQYYKSRNTRNHHTVCSTEHRIVMFSIYGILLIIGMSCAQIAILEFIFRESRKHNV-------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . :*:* : : * * .:.: : * : . . *.* :*: . . : : . . . : : .* : :: : *: .. : * . : :. * :. :* ", "identical_positions": 13, "similar_positions": 43, "identity": "5.31%" }, { "cls_id": "homologset.agr.HGNC:17292", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BY89-1", "uniprot_id": "CTL2_MOUSE", "id": "Q8BY89-1", "name": "Choline transporter-like protein 2", "aln": "MGKDSQNYYGKHGTPQKYDPTFKGPIY-NRGCTDVICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNADKPFLFYFNIVKCANPLVLLEFHCPTPQICVKQCPDRYLTLLSARNTR-DFDYYKQFCVP------GFQNNKGVTEILRDGECPAVITPSKPLAQRCFPAIHA--------------------------------------------SKG-VLMVGNETTYEDGHGARKNITDLVEGAKKANKILE----------------------ARQLAMQIFEDYTVSWYWIIIGLVIAMVLSLLFIVLLRFLAGIMVWVMIVMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSLLYPLVTFFLLCLCIAYWASTSVFLSTSNTAVYKVVDDTA-----------------CPLLRKTCNPETFPLRNESLQCPTARCQFAFYGGESTYHRA-----LLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDDMPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLN-------------------------------------------------------------KTNKKVAES------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B4F795-1", "uniprot_id": "CTL2_RAT", "id": "B4F795-1", "name": "Choline transporter-like protein 2", "aln": "MGKDSQHYYGKHGTPQKYDPTFKGPIY-NRGCTDIICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNADKPFLFYFNIVKCASPLVLLEFHCPTPQICVKQCPDRYLTFLSARNSR-DFDYYKQFCVP------GFKNNKGVAEVLRDGECPAVIIPSKPLAQRCFPAIHA--------------------------------------------SKG-VLMVGNETTYEDGHGTRKNVTDLVEGAKKANKVLE----------------------ARQLAMQIFEDYTVSWYWIVIGLVIAMLLSLMFIVLLRFLAGVMVWVMIVMVILVLGYGIFHCYAEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSMLYPLVTFFLLCLCIAYWASTSVFLSTSNVAVYKIVDDTP-----------------CPLLGKTCNPETFPL-NESRQCPNGRCQFAFYGGESTYHRA-----LLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDDMPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLN-------------------------------------------------------------KTNKKVAES------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8IWA5-1", "uniprot_id": "CTL2_HUMAN", "id": "Q8IWA5-1", "name": "Choline transporter-like protein 2", "aln": "MGDERPHYYGKHGTPQKYDPTFKGPIY-NRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSR-DFEYYKQFCVP------GFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHA--------------------------------------------YKG-VLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLE----------------------ARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSP-----------------CPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRA-----LLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLN-------------------------------------------------------------KTNKKAAES------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BD93-1", "uniprot_id": "A0A8M2BD93_DANRE", "id": "A0A8M2BD93-1", "name": "Choline transporter-like protein 2", "aln": "MEPEEKNPESKYGEPRKFDPTFKGPIY-NRGCTDILCCILFILALLGYFAVGILAWSQGDPRKVIYPTDSTGQFCGQAGTPLEKKPLLFYFNIMKCASPLVLLEFQCPTTQICVEKCPDKFMTLVNALKSQSDKTYYTQFCKE------GVDMTKNAPQILSEGLCPSILFPSKNFTRRCLPALET--------------------------------------------MKGGVVVIGNETQFTVDQGEVINATDLLNAAKKSNVVVE----------------------ARAVAMRIFEDYTQSWHWILLGLVIAMLISLIFILLLRFLAGVMVWVMIIMVIIVIGYGIFHCYMQYASLKGQAGSDVTIKDLGLQTDFSVYLQIQQTWLAFMIILCIVEAVILLLLIFLRKRLLIAIALIKEASKAIGHVMSSLFYPLLTYALMSLVIAYWAITAVFLSTSNEPIYKVFNTSN-----------------CSYSRATCNPATFNTSNVTTECPDAECLFAFYGGETLYHKW-----LIVFQFYNLFLFFWCVNFVIALGQVTLAGAFASYYWAFKKPDDMPAFPIFNSLGRALRYHTGTLAFGSLILAIVQVIRVVLEYLDQKLKGAQNKFAKFLLSCLKCCFWCLEKFIKFINRNAYIMVAIYGKNFCTSARDAFFLLMRNIVRVAVLDKVTDFLLFLGKLLIVGIVGICSFFFFTGKIKIAQDVTPALNYYWVPILTVVFGAYLIAHGFFSVYAMCVDTLFLCFCEDLERNDGSSDKPFFMSPELHQILSIEKSIEETDHAEVPVIQVQAEEEIPLQENGEVQLKQQTVLKQDQEEETPLNQETHIEEAPQETQTQAPEASAVAEEKPEEQVTAQEHEPTQATPQQNGPQEVDAEDKEEPGAQAEPPQAENLQAPEPEEPKPQENGPQESDTLLTPQE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7SYC9-1", "uniprot_id": "CTL2_DANRE", "id": "Q7SYC9-1", "name": "Choline transporter-like protein 2", "aln": "MDMEEK---PKYGEPRKFDPSFKGPIQ-NRGCTDIVCCIIFIIAILGYLAVGILAWTHGDPRKVIYPTDSMGQFCGQG--KLEKQPFLFYFNMMKCASPMVLLEFQCPTPQVCVQTCPNRTMTLITAISKPQDWEYYKSYCKE------DPG-HKAAAQILKEKLCPAYLVSSNPFLQRCFPSMG---------------------------------------------KKGEVITVGDQEKFSDGVN-VLDAKDLMAGMKNASIVME----------------------GRQVAMKIFEDYTKSWYWILICLLIAVVLSLIFIVLLRFLAGVMVWVMILMVVAVIAYGIAHCSIKYVSLKDTPGSNITLQQLGFQPDFAVYLHIRQTWLAFIIILAILELIIILLLIFLRNRIRVAVELMKEASRAIGYVMSSLVFPIFTFFLLAIVIAFWGVNAVFLSTSSEPVYKVFNETE-----------------CVHSRETCNPENFTSSSMKSDCPHSQCLFAFYGGETPYHKY-----LILLQFYNVFLFFWCANFVTALGQMTLAGAFASYYWAFDKSKDMPAFPLCASLGRSLRYHTGSLAFGSLLLAIVQVIRVLLEYIDHKLKGAENKFAKFLLCCLKCCFWCLEKFIKFINRNAYIMVAIYGKNFCRSARDAFFLLMRNVVRVVVLDKVTDFILFLGKLLIVGLVGIFAFFFFSGQTDAFKGTAPSLHYYWVPILTVLVCSYLIAHGFFSVYAMCVDTLFLCFLEDLERNDGSAERPYLMSENLLNVLK---------------------------------------------------------------KKNQAN-------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VAP3-1", "uniprot_id": "CTL12_DROME", "id": "Q9VAP3-1", "name": "Choline transporter-like 2", "aln": "-MTESVELMNKYGEPLRYDRNFTGPRQRDRSCTDVPCLLLFVLFLGGWAFIAQYAIRNGDLNKLLVPTDSFNRKCGMDSGVLNKK-NLFFFDLNQCIDPLVPITG-CDTPQVCVETCPRETFVWDTMKDKQSFAELHSRLICLSEEHKAQIRTKSDIQDAINQNQCARWYIKSAPFLKRCLFEFSQGVCDYIPSFLLNGGRSRRELHMLPGNATTEVQMQADVMYQKMTDAQALVVPQANGKQTPVDEEPIIQCKRRLNEAVIKEKMMQTDTRLAKLVGNMVAHFYNGTNDAQLLGEKIVEDLVNSWSIVLVACFCTLVASLIYIALMRWLSAPILWFSIFGVLIGLLVGIYFSVKQYIHWENTP--TVPVHGLNLHSTVKNVLQNQNTWLYLSIFVGVCFVVILLLVIVLRKRIRIAIALTKEGSKAVSSVISTVFFPIFSWILFIAAIAFAIGVGLYLGSIGDPSFRMVRQLTKSGEVTTEDCVCEGPAINYTVGGSCKPEVFQQYCSVRLTSFFQNRNPCLNTTCSFDSINNPIEIKWAIFYNVFGFLWLSFFISAFSYMVLASTFARWYWTFKK-RDVPYFTLTRAFFQTAVYHLGTVAFGSLILAIVRLIRLVLEYIHEKLKKYDNAVTRAILCCMRCFFWLLETFLKFLNRNAYIMCAIHGKNFCSSAADSFNLIMRNFLRVVTLDQVTDFLFFLSKLLLTAGAGASTYYFLDNNPSIIR-----LNYIAVPTTVVVIAAFLITSVFFGVYSTAVDTLFLCFLEDCERNDGSPEKPFFMSKQLMKILG-------------------------------------------------------------KKNNLPPRQRRGK--------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : *:* * ::* .*.** :*.***: * :::.: : *: :. * :** .*:: **** .. ** .: **:*:: :* .*:* : * *.*:**: ** . :. . .. :. . : : : *. * : :**: : :. *: .: . : . : . ::: .: :. :*.** . ** ::: . :: **::* *:*:*:. ::*. *. *: : ** .. :* .. . :.: *.::. . *: ::**: : *:: : :*:**:*.**:*: :*: * **.*:*:. *:.::.:*:.:: *: **: .::*.: . . :::. :*:* * . . . . :. : ::* * *:* *: *:. :.**.:** :**:: * *:* *.: :: :: ** *::***:*:****::**::***:..:** :* .:: :: *::* ** **.*:**:******* **:*.*** ** ::* *:***.:**..**:****:::*.***:.. .* :::*: . : *:* ** .*:. ::**: **.**. .******** ** ******.::*::** * ::* :. .. ", "identical_positions": 195, "similar_positions": 245, "identity": "20.7%" }, { "cls_id": "homologset.agr.HGNC:17293", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIS9-1", "uniprot_id": "KPCD2_RAT", "id": "Q5XIS9-1", "name": "Serine/threonine-protein kinase D2", "aln": "MAAAPSHPAGLPCSP---GPGSPPPPGGSDLQS---------------------------LPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSAADIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGSSESLPCTAEELSRSTTDLLPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEAL------INGDVPME--EAADYSEAD----------KSSLSD-----------------------------ELEDSGVIPGSHAENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITANVTYFVGETP---------GGAPGGPS------GQGTEAARGWETAIRQALMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMG-ERYITHESDDARWDQFVSER------HGTPA-------------------EGDLGGACLPQDHEMQGLAERISIL--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BZ03-1", "uniprot_id": "KPCD2_MOUSE", "id": "Q8BZ03-1", "name": "Serine/threonine-protein kinase D2", "aln": "MAAAPSHPAGLPGSP---GPGSPPPPGGLDLQS---------------------------PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSAADIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGSSESLPCTAEELSRSTTDLLPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEAL------INGDVPME--EAADYSEAD----------KSSISD-----------------------------ELEDSGVIPGSHSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITANVTYFVGETP---------GGAPGGPS------GQGTEAVRGWETAIRQALMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMG-ERYITHESDDARWDQFVAER------HGTPA-------------------EGDLGGACLPQDHEMQGLAERISIL--------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZL6-1", "uniprot_id": "KPCD2_HUMAN", "id": "Q9BZL6-1", "name": "Serine/threonine-protein kinase D2", "aln": "MATAPSYPAGLPGSP---GPGSPPPPGGLELQS---------------------------PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASS-YTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEAL------INGDVPME--EATDFSEAD----------KSALMD-----------------------------ESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMP---------GGTPGGPS------GQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMG-ERYITHESDDARWEQFAAEHPL--PGSGLPT-------------------DRDLGGACPPQDHDMQGLAERISVL--------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PLD4-1", "uniprot_id": "A0A8M9PLD4_DANRE", "id": "A0A8M9PLD4-1", "name": "Serine/threonine-protein kinase", "aln": "MANVSPFMSPGPMSQVFFPPGGPSPPGSVVLQQGTPVSVHASQTPGFPTMDMGVVSGPGGASGMLPGPPAP-AGVSFIIQIGLTRESVLLPQTA-DLAYVKQIACSIVDQKFPECGFYGIYDKILLFKHDTSSNNILQLVKAVSDIQEGDLVEVVLSAA----ATFEDFQIRPHALNVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSTTSLTSSQSLRLSTTESLSSLNSSMTSEEASLIRSHTQMPRTPSEARRFYTGRPVHLDKILMTKVKVPHTFAVHSYTRPTVCQYCKRLLRGLFRQGLQCKDCKFNCHKRCAYKVPNDCLGETLDILSPSTDAEVPMD--YSSEFSDSD----------KSSLID-----------------------------DSDEACSIPGSFSP----DSSQDRSSGDQSSN----IPLMRVVQSVRQTTRRSSTAIKEGWMVHYSNKDTLRKRHYWRLDCKCIILFQNDTTNKYYKEIPLSEILEVRSAGDFSLVPAGTSPHCFEIMTGTMIYFVGEDPNTSSPSSSISGLPVSPSSVVPNSGVGREVAKGWETAIRQALMPVIFQDNPPAEGHTPHRQASVSISVSNSQIQENVDIGMFYQIFADEVLGSGQFGVVYGGKHRKSGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHLGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILAALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIHNAAFMYPPNPWKQISPDATDLINNLLQVKMRKRYSVDKSLSHAYLQDYQTWLDLRELESKLG-ERYITHESDDSRWQQYARDHTLPYPPHLVPP-------------------PPASDDEDGNEDADMQGLTERVSIL--------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4KHC3-1", "uniprot_id": "A0A0B4KHC3_DROME", "id": "A0A0B4KHC3-1", "name": "Serine/threonine-protein kinase", "aln": "---------------------------------------------------------------------MEGPEVTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKCDGCGQNYHKRCVVKIPNNCN-------RSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSSSLNIPGRHQRTHSSGSRNGLMV--LRIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKYHKELPLAELLSIESHLGD---PRPECNYCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDS------GIGSDIAKSWETSIRQAFMHVTN----------------TQCCESEEQVQD---MGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWDCAGDMXPGCEPEAILESTTELISCSANTTTESYRRSPADCAGCHRLSDCGNSPKSEAMSDRALKWMRFHLCRHIK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . *:* :*:* .*: * :* : * :*::**.::: *:*:.*: : ::**** ** :: *:*:::.: .:: : ***:**:*: .* * ::**:*.****:.*:***.******************* ******...*****. :.. :* :*. * :..* . .. . . . . . * . : ::: :::**** :*:* ***** **:**:***:*****:**::* **:* :**:** **: . : ::.::* **:: . : :.*. : ...:.... :.. *****:****::*.::.. :::***:***:. *. **:*****.* * ** .: .:*:**:**:*:* :.. . * :***: . ****: * * * * * : .:.***:****:* * . . *:.*:*: :. .****.*************** *:*: *:**:*************:**:*******.: * *:**** ******::*******:********* :***.**:********* **::** :**************:* **********:************************* *:**************:************:*******:*******..**..**..* ********** ****:***** * :**: **: ***:**.::* **:***:** **: . . .* . :* :* ", "identical_positions": 405, "similar_positions": 209, "identity": "40.02%" }, { "cls_id": "homologset.agr.HGNC:17294", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A5PF31-1", "uniprot_id": "A5PF31_DANRE", "id": "A5PF31-1", "name": "", "aln": "---------------------------MSGVTRKGS-------GRPG--------------------YYYRLLGRTRLQRQRSRS-------------------RSRSRVTNNKDSPPERTGRRRSIPGSAPDKVPPTMEPTAAAAATPFRVTGFLSRRLKG-------SIKRTKSQPKLDRNSSFRHILPGFR----PVDNE-RSHLMPR----LKESRSHESLLSPTSAVEALDLSMEEEVLIKPVHSSILGQDYCFEVSTST-GSKCFSCRSAAERDKWMENLRRAIHPNKDNSRRVENMLRLWIIEAKDLPAKKKYFCELCLDDSLYARTTCKMKTDNVFWGEHFEFNNLPAVQSITVHVYRDSDKKKKKDKNNYVGLVSIPVVTVTSRQLVEKWYPVSQPNP--------------GKGKAAGPMVRIKARYQSMNILPMELYKEFAEYTTNNYMLLCSVLEPVISVKNKEEMACALVHILQSTGKAKDFLTDLMMSEVDRCGENEHLIFRENTLGTKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSSS---DLPEHQSNLRMCCELAFCKIIESYRVFPRELKEVFASWRQECGNRGRPDISERLISASLFLRFLCPAIMSPSLFNLTQEYPDDRTARTLTLIAKVTQNLANFTKFGNKEEYMSFMNQFLEQEWTNMQRFLLEISN---PETISNTAGFEGYIDLGRELSTLHSLLAEVLSQMDQSAASKLGPLPRILRDVHGALTNPTNVQMSV--------------PSDRVPSPPVPGCSISTG-------------IQKMAIDSDLPGPVDFTR-LPSPTPENKDLFFVTRSSG---LQGSPTRSSSYSEANEPELGLANGGKSLSMVDLQEA----ARALEPISIPAGITSEGMGEGAMVP-WNARTPQGN----------IAGGPTLHRPVQSPTTPG-AEGAPGRPTQLLAPLSFQNPVYQMAAGLPVSARGNASGDSGS-----------------------ECHSSVSSHSNNEECLGGTKTTFLTQ------------------------------------------------GASVGEEFARRSGDFSRRQLSLTDPQHGNQPTVPRQS----------------SAGPQRRIDQPPPPTQ---TAPRGRTPPNLLNSGPYPRPLNNTMMSSSPD-------------------------------------------------------------------WPGSGARLRQQSSSSKGDSPETKHRAPHKQAPSPVNPSALDRTAAWLMN--VPYIEQE--------PETELCRDEHTQAEKYQAEISMLQDRLRMSVQRLEEYEARLK---------------------------------------------------------------------GQEEQAQKMLLEYQARLDESEERLRRQQE-------------------DKDLQMKGIISRLMSVEEELKKDHADMQAVVDSKQKIIDAQEKRIASLDAANARLMSALSQLKERYSMQTRNGISPTNPTKLQITENGEFRNSSNC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M6YZX5-1", "uniprot_id": "A0A8M6YZX5_DANRE", "id": "A0A8M6YZX5-1", "name": "", "aln": "-------MFGGPTPISPHITRCQHQGWMRVTDMKGSSVHWLSCGQPLSEPIGWQVKFCLVAECQLVLLDKREISPLLFQERRAESCTVWLLRRSTSIPEGVQLRKDQSTQTRNTKSLADRVGRRRSMPGSTVDKTVVAMD---ADTSTPFKVTGFLSRRLKG-------SIKRTKSQPKLDRHSSFRNILPGFK----SAENDSRSHLMPR----LKESRSHESLLSPSSAVEALDLSMEEEVLIKPVHSSILGQDFCFEVTTST-GSKCFSCRSAAERDKWMENLRRAVHPNKDNTRRVENMLKCWIIEAKDLPAKKKYFCELCLDDTLYARTTCKLKTDNVFWGEHFEFNNLPSVKSITVHLYKETDKKKKKDKNNYVGLVNIPIATVTGRQFVEKWYSVSTPNP--------------NKGKSPGPMVRMKSRYQSMSILPMELYKEFAEYITNNYMLMCSVLEPALSVKNKEEMACALVHILQSTGKAKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSSS---DLHEHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFSLMQEYPDDRTARTLTLIAKVTQNLANFTKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN---PETISNTAGFEGYVDLGRELSSLHSLLSEAVSQLDQTTITKLGPLARILRDVNSALTNPTGAPVPS--------------PTERVGSPSLPSSSLSTG-------------LQKMVMDSEITGLVDFTR-LPSPTPENKDLFFVTRNSV---IQPSPARSSSYSEANEPDVQIPNGSKSLSMVDLQDSRSLESAANTSFSDPINDSQASAGQSAGM--WTTRTIKGN----------TPSGPTLRRAGQTPTTPS-TESAPGR-SQLLAPLSFQNPVYQMAAGLPVSPR--AVADSGS-----------------------ECQSSISSN-AEEAATAGPKHPFISQSSTGASG----------------------------------------GGGSSGDEFIQRPGEFTRRQLSLTETQH--QTNVPRQN----------------SAGPQRRIDQPPP------AITRGRTPPNMLNTAPYPRPSSGSMMSSSPD-------------------------------------------------------------------WPSSGTRLRQQSSSSKGDSPESKQRTLHKQAPSPVNPNALDRTAAWLLNMNVQYLEQEGIDPDSKHREDFPNKEDLTPTEKYQHEIAVLQEKLRISAKKLEEYESRMK---------------------------------------------------------------------SQDDQTQKMLLEYQARLEDTEERLRKQQD-------------------DKELQMKSIITRLMSVEEELKKDHSDMQAIVDSKQKIIEAQEKRIASLDAANARLMSALSQLKDRYSMQTRNGISPTNPTKLQITENGEFRNSSNC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q3UHC7-1", "uniprot_id": "DAB2P_MOUSE", "id": "Q3UHC7-1", "name": "Disabled homolog 2-interacting protein", "aln": "-------------------------MSAGGNARKST-------GRPS--------------------YYYRLLRRPRLQRQRSRS---------------------RSRTRPARESPQERPGSRRSLPGSMSEKNPSMEP----SASTPFRVTGFLSRRLKG-------SIKRTKSQPKLDRNHSFRHILPGFRSAAAAAADNERSHLMPR----LKESRSHESLLSPSSAVEALDLSMEEEVIIKPVHSSILGQDYCFEVTTSS-GSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTSKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNP--------------KGGKGPGPMIRIKARYQTVSILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSSA---DLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN---PETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLDQSVVSKLGPLPRILRDVHTALSTPGSGQLPG--------------TNDLASTPGSGSSSVSAG-------------LQKMVIENDLSGLIDFTR-LPSPTPENKDLFFVTRSSG---VQPSPARSSSYSEANEPDLQMANGSKSLSMVDLQDARTLDGEAGSPVGPDALPADGQVPATQLLAGWPARAAPVS----------LAGLATVRRAVPTPTTPGTSEGAPGR-PQLLAPLSFQNPVYQMAAGLPLSPR--GLGDSGS-----------------------EGHSSLSSHSNSEELAAAAKLGSFST---------------------------------------------------AAEELARRPGELARRQMSLTEKGG--QPTVPRQN----------------SAGPQRRIDQPPPPPPPPPPAPRGRTPPTLLSTLQYPRPSSGTLASASPD-------------------------------------------------------------------WAGPGTRLRQQSSSSKGDSPELKPRAMHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKEELSQAEK---DLAVLQDKLRISTKKLEEYETLFK---------------------------------------------------------------------CQEETTQKLVLEYQARLEEGEERLRRQQE-------------------DKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGVSPTNPTKLQITENGEFRNSSNC---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6P730-1", "uniprot_id": "DAB2P_RAT", "id": "Q6P730-1", "name": "Disabled homolog 2-interacting protein", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNP--------------KGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAA---DLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN---PETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLDQSIVSKLGPLPRILRDVHTALSTPGSGQLPG--------------TNDLASTPGSGSSSVSAG-------------LQKMVIENDLSGLIDFTR-LPSPTPENKDLFFVTRSSG---VQPSPARSSSYSEANEPDLQMANGSKSLSMVDLQDARTLDGEAGSPVGPEALPADGQVPATQLVAGWPARAAPVS----------LAGLATVRRAVPTPTTPGTSEGAPGR-PQLLAPLSFQNPVYQMAAGLPLSPR--GLGDSGS-----------------------EGHSSLSSHSNSEELAAAAKLGSFST---------------------------------------------------AAEELARRPGELARRQMSLTEKGG--QPTVPRQN----------------SAGPQRRIDQPPPPPPPPPPAPRGRTPPTMLSTLQYPRPSSGTLASASPD-------------------------------------------------------------------WAGPGTRLRQQSSSSKGDSPELKPRALHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKEELSQAEK---DLAVLQDKLRISTKKLEEYETLFK---------------------------------------------------------------------CQEETTQKLVLEYQARLEEGEERLRRQQE-------------------DKDVQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMRARNGVSPTNPTKLQITENGEFRNSSNC---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5VWQ8-1", "uniprot_id": "DAB2P_HUMAN", "id": "Q5VWQ8-1", "name": "Disabled homolog 2-interacting protein", "aln": "-------------------------MSAGGSARKST-------GRSS--------------------YYYRLLRRPRLQRQRSRS---------------------RSRTRPARESPQERPGSRRSLPGSLSEKSPSMEP----SAATPFRVTGFLSRRLKG-------SIKRTKSQPKLDRNHSFRHILPGFRSAAAAAADNERSHLMPR----LKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSS-GSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNP--------------KGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAA---DLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN---PETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPG--------------TNDLASTPGSGSSSISAG-------------LQKMVIENDLSGLIDFTR-LPSPTPENKDLFFVTRSSG---VQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVN----------LAGLATVRRAGQTPTTPGTSEGAPGR-PQLLAPLSFQNPVYQMAAGLPLSPR--GLGDSGS-----------------------EGHSSLSSHSNSEELAAAAKLGSFST---------------------------------------------------AAEELARRPGELARRQMSLTEKGG--QPTVPRQN----------------SAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPD-------------------------------------------------------------------WVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEK---DLAVLQDKLRISTKKLEEYETLFK---------------------------------------------------------------------CQEETTQKLVLEYQARLEEGEERLRRQQE-------------------DKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8T498-1", "uniprot_id": "GAP2_DROME", "id": "Q8T498-1", "name": "Ras GTPase-activating protein raskol", "aln": "MGRRTYLSRSSTISYPSRIEGWLDVCETEGELTRLIKTLPWGPLYCVLQQDDQTFTAYCSEEISLGDVCYEDIPRVRLDRVRRPAKALWDGPPTLVEENEDSDSCVGGSGGMSGINDIVLNTTLYSELGEYKSKTLPRIHFDTALNDTSLNEDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLSALTALRQRYETQQQQQQHQAPPKTQKPQ--------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P33314-1", "uniprot_id": "BUD2_YEAST", "id": "P33314-1", "name": "Inhibitory regulator protein BUD2/CLA2", "aln": "---------------------------------------------------------------------------------------------------------------MSSNNEPAQSRTSYFKLNEFLSNVKHYKN--------TFKGEIQWCNNLSLN--------DWKTHYLQITSTGALTHSIDELTADSTNIQPIIKHLQQCR----------IEIIKDKHSSFKDINANCN---FIIQVNTSGKDNKVYLRVKSWSDFKKLLTCL------IWWSSMKTNGIFNKFQVSRPLEFKSKKMAKPESLLVYKLNVFGPIVKNIVLPPATNILESPDIINNDDNSVGWFSAMGVLKSNGMLDLLLQSDGSLIYSLNISQLLRSEIR----ILDSSVLQSENS---------------LFLGELPLLRSQLGLEKFRIENIASAATNSSDIS---------QEIIVEFPLRIDLEDCFIALQS--------FARSEYLSITGSDKSNDMKIS-NSFKISILEANFQSINLNDKNNTPWSIFTDITAWGHTWARTSMVSNSS-------NPFWREEFQFNELLRLTNSYLEIKQLFHDLNN--KKRLRLIGKIKITQEIINDTRYNKETRLPIMDVDNKNFQIGTICIKISSNLNFILPSTN-FVKLEKLLMN-ANLSMVSNLIYKSSSSMENDNKLTQT--------SIIFLDIFQSLSRIEEWFHVLIDKELAKIDG-TVSRINQKNLDSKHVFNSLFRGNSILTKS--------------IEQYFFRVGNEYLSKALS------------AILKEIIESNKSCELDPARVKEKDEVKKRKIIADNYKRLYSWVTKIWKRLYATSNDLPIEIRNVLKIFRQKLEIICIDDTLQIILNGISGLLFLRFFCPVILNPKLFKYVSQNLNET------------ARRNLTLISKVLLNLSTLTQFANKEPWLMKMNNFIDKRHNDLLDYIDKMTQKKLDFNSK---------------------ILNLSSTISRPKLAIEQTMLDDLPQIPY----------------------------------------------------LLDKNLRETEFVNLIVNFSQEDMTKMEKYNHMD----------------NGGKGELIEEEGLLSGSSLNLSVDKKD---LDSPIEVKPEIGELEFEKIT---------------------------------------------------------------------ENNTEIFGDDLMNLLKSDDVGSRSRDLDNGANSG----IKFNSIIPKAEEEKHAMKELEQESCLLYNRINHIRKRLSGYECASSTLFEDKKYSISLSHKIFYEEIK---------------------------------------------------------------------EGKEIVLKLLNKPTNENSSARLQKFFTKG----------------VSSKSNNTVGDSYCKFLTIDVSDENPKSSNKTSVHGTSSENGAKDDYLTLPNSQGKGNLGNRFSPTKLSRIMRKPPNADVPKEQNSRKLTRWFKKKKETGGS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:: * : * . : :.:.* * . :.. : :: ::: :: .:. .. :. : :. : : :.. . :. .: : . : :. * :* : :. * : . * : : :: .:: : :: .: .. : : : *:: . :* :: . : ::: :. : . . ..: : . : :*: : ::: ::. *: .:::.:*. : : : .*:. . .: : : .*.:: : :.:: :: : :.::.::: :. : *:. .. . : . .: . :* *: : :::: .:. .: : . : . . : :.. . . * . ::.:: . : : .: . . . : . . . : : . : . . ... : :* : : . . . .. . . . .. . .. :* . :.: : . .* . : : . : . : . .: ::: : : . : : : . . . . ..: : . :::::: . .. : . . : .. : . :: :: . :. . : . . ", "identical_positions": 22, "similar_positions": 284, "identity": "1.38%" }, { "cls_id": "homologset.agr.HGNC:17295", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JVZ7-1", "uniprot_id": "A0A0G2JVZ7_RAT", "id": "A0A0G2JVZ7-1", "name": "", "aln": "----MREPRKGFRARLARVLTGLGGRRERKGKISKEARLQDRPWGGQSCPDLAQSQGSTNDVSLKVQTQSHSEWDLRVRSHGGLWTQRRLHTSGRRSEPLGRLQRPAVG----------------SACDLAGYDSMEHECPAGTGSTEAIGGPSHPSRPESASPSLKQGSPGAPCQHPQHGAPEVLLKPELPGNLEDAPLLPRPDSFLTAAGAKGKPDTSGSAQSEPEPLHTRLCVRRTRYHITVTLQGCG-------------------------------------PAPGEEGKEPARPAPHPCGPEESRGWQEPPQKLRPITGYPINPPGEPPPRVPQHQGSKAQQERRVGWEPGFPHSREPVHRVAGASRVLLEPNMEGTTGSSARAEARVVSATLTWRQRPPAQEESRHRFHKVSLVSGARTEAPQEDVFEHSFRRE-EVNGFVKKEEEIVNCQGPREESGPMNFQSHGPIFSKKYIPPPKEKRPTMRLQEAADWGDGG----PQAPRTEPPGMGSMARTELLVPLPGPREPSPHPNVGVTSG--GSRNREEWRVTRTVR-TTTTTVVGGHVDRQVSSSVSVGPSVSGEALPRGRN-----------------------VTRTIRAVVVSPRAEGSPSRSQALEVLSNLVPAERIPPASRIPRLTMFTSR-------------------------------------GSGLGGTVGNTLGPPPETSPAELKTESSAPAPVGVPEVAHPPQNIDIPAAQLIQDQGGVSDARTVESSRLQRTSSPVLFPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTSQSQDRAPSSPKPQPCASS--PAHSPEQPVAPARLKAQASPHVLP-SVKEKFAGLP---------------------------VAPVPPMTG-IEVTKPEAPPNPSSPRRKAVPSSQSPCAPASPKDKFVQGPENRPSSALTQEEVFPGPRVPAHSHSP-----------------------------------------------------------------------------------------------------------------------------------------KEVLQARGAPIPSSSMPTTAVQDAEGGPSIKKEVGQDPQNSP------------------------------------------------------PRSLPCKETVEGPTAPGPLTPKQDVLVQESPGNSLSSPTPEECFQSPAVPLAPPSSEAKKPLSLEGSQAPEPMKAEASTESQLIPDSTEGTVPSEPS--------------REEDEAALTADLEIFLDTLRSMEPPEILRTHRLPRAPRSSYLAMYATLPAIEEDQ-LGPCVLGPSPQEGPSLEEEEE-------ELENPYLSDDEKLQ--RRQEKAAPGPSLDPHPSRPAKVTCSPMEMMKKLVAGQ-------GPEPQPSNRPTSRLGGSLLFG----------------------------------------------------------------NLVPANKDASALEPLGTKLSALPPHGAPGVRKVPGQLPLLCSGGP-PPEKPAPIQP-----------------------PEGWSPALKTQGKLNTRPGKVILFSEPGCQGRGREVWEDVADASAWAS--VASIRVIRGCWILYEQPEFRGQKLLLPEGDVELRALASTWSLQ---------------------------------GIGSLKRAVRDYCTPRISLFSEEGLKGKPVTLMGDLKDSQGLERPLQVASATVTAGLWLLYPKPFFEDTPCILEPGEYPTLEAWGTSGLSVGSLKPMRLGCPSVEKPGEPKAVVYEAPDFQGQSWEVSGDIYNLQQPED-SQSPQLTSVGSLRILGGCWVGYEKEGFRGHQYLLEEGEYADWSHWGGYDELLTSLRVIRTDFGDPAVVLFEDMDFQG-----HRVEVSSALPDVELAQHGPNTQAIHVLSGVWVAYEQVGFSGEQYILEKGVYRNCDDWGSGNCALGSLQPVVQVGESDLHFVSKIQLFSGPNFLGDHISFEDDQASLPASFHPQSCRVHGGSWVLFEDKNFEADQHIVSEGEYPTLTAMGCLASTVLGSLRKIPLHFSEPSLSLFGLECFEGKEIELTGEVRSLQAEGFNNHVLSVRVQGGVWVVCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRAYFRLWNAALGGFLSVPDHVEDMKAGRVVVSEPRAGGSCIWYYEEGLLKNQVAPTMSLQVIGPPSPGSKVVLWAESRLPRQTWSISELGHICSQMFEGQILDVKGGRGYDRDHVVLWEPTKDRPSQIWTVHVL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A2I3BQG2-1", "uniprot_id": "A0A2I3BQG2_MOUSE", "id": "A0A2I3BQG2-1", "name": "", "aln": "----MREQRRGFRARLAQVLTGLGGRRKRKGKISKEARLQDRPWGSQSCPDLAQGQGSTNDVSLKVQTQSHSEWDLRVRSHGGLWSQKRLHSSGRQTDPLGRLQRPAVG----------------SACDLAGYGSMEHECPALAGSAEAIGGPSHPSGPEPASPSLKQGWSGTPCQHSQHSA------PELPGNLEDAPLWPHPESFLTAARAKGKPDTPGPAEPEPEPVHTRLCVRRTRYHITVTLQGCG-------------------------------------RAPGEEGREPARPAPHPCGPEESRGWQEPPQELRPITGYPINPPGEPPLKAPQHQGSKVRQKLLVGWEPGIPHSREPVHRVT--------RKMEETAGSPARAEARVVSATLTWRQRPPVQEESRHRFHKVSLVSGARMEAPQ-DVFEHSFRRE-EVNGFVKKEEETVNCQGSGEEPGSTNFQSHGPIFSKKYIPPPKEKRPTVRVQEAADWGDGG----PQAPRTELPGMGSMARTELLVPLPGPREPSPHPHVGVASG--GSRNREEWRVTRTVRTTTTTTVVGGHVDRRVSSSVSVGPSMSGETLPRGRN-----------------------VTRTVRAVVVSPRAEGSPSRSQALEVLSNLMPAERIPPASRIPRLTMLTSR-------------------------------------GSGPGGTVGTTLGQPLEISTTELKNSISALAPVGVPAVDSPAQNIDIPVAHPIRDQGGVSDARTEESSRLQGASS-VLLLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTSQSQVPASSSPKPQTCAAS--LTQSPEQPVVPAHLEAQSTPHVLP-AVKEKFTGLS---------------------------TVPVPPTAK-GEVTVPEPPPSPSSPRRKAAPSSQSPCAPASPKSKFVPDPENVPSSALTQKEVYPCPSVPAHSHIP-----------------------------------------------------------------------------------------------------------------------------------------KEVLQAHGAPKTSSSRPTTVVQNAEGGPSIKKEVGQYPQNSPS-----------------------------------------------------PCSVPCKETVESPTFPAPLPPKQDEVVRDSPGNFLSSPTPKGSFQSP--PFAPSSSEAKESLSLEGSPASKPMGAEVSTGSQTIPDSTEGKVPSEPS--------------EEEDEAALTADLEIFLDTLRSMEPPEILRTHRLPRAPRSSYLAMYATLPAIEEDQ-LGPCVPGPGPQERPVLEEEEEEVEEEEEELENPYLSDDEKLR--RRQEKAGPRPSLGLHPPTPAKVTCSPMEMMKKLIAGQ-------GPEPQPSNRPTSRLGGSLLFG----------------------------------------------------------------NLVPANKDAPALEPLGTKLSALPPHGAPGVKKVPGQLPLLCSGRP-PPEKPAPIEP-----------------------PEGWSPAPKTQGKLNTRPGKVILFSEPGCRGRGREVWGDIADASAWDP--VASIRVIRGCWILYEQPEFRGQKLSLPEGDVELRALACAWSLQ---------------------------------GFGSLRRAVQDYCTPRISLFSEEGLKGKPVTLTGDLKDSQGLERPLQVASATVTAGLWLLYPKPFFEDTPYILEPGEYPTLEAWGTSGPSVGSLKPMRLGCPSVEKPGEPKAVVYEAPGFQGQSWEVSRDIYNLQQPED-SQSPQLTSVGSLRILGGCWVGYEKEGFRGHQYLLEEGEYADWSNWGGYDELLTSLRVIRTDFGDPAVVLFEDMDFQG-----HRVEVSSALPDVELAQHGPSTQAIHVLSGVWVAYERVGFSGEQFILEKGVYRNCDDWGSGNCALGSLQPVVQVGESDLHFVTKIQLFSGPNFLGDHISFEDDQASLPASFHPQSCRVHGGSWVLFEDKNFEADQHIVSEGEFPTLTAMGCLASTVLGSLRKVPLHFSEPSLSLFGLECFEGKEIELTGEVRSLQAEGFNNHVLSVRVKGGVWVVCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRAYFRLWNAALGGFLSVPDHVEDMKAGRVVVSEPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPRQTWSINELGHICSQMFEGQILDVKGGRGYDRDHVVLWEPTKDRLSQIWTVHVL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N1P7-1", "uniprot_id": "CRBG2_HUMAN", "id": "Q8N1P7-1", "name": "Beta/gamma crystallin domain-containing protein 2", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEAGGPMARAKARVVSATLTWRQRPPTQEEIKHGFHKVSLVSGAQMEAPQKEMFEFSRREEVEVNGFATQEEETVNCQGPRDTAGSKNFQSHGPIFSKKYIPPPKEKRPEGRLKEAVDQSDGS----RQAPRTEPPCVGAMARTELLVPLPGPREPSPHPGVGLTSG--SSRSLEEYRVTRTVR---TTTVVGGHVDRRMSSSVTVRPVSSGEALPRGRQ-----------------------VSRMVPPVVVGS-PPGSPSRSQAVKVLSNLVPAGHSPPASHLPRPTAGGPR-------------------------------------STGLGSTVGAALRQLPETGTAELK-DSSALASTGIPASAHLPKNQDAPAACPDRDQGRAPDARACELWQVLGAPSSTELPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTPLVLPPKKKDGPVDPP---------------------------AATVLPMVRSEHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSL------------------------------------------------------APPLTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEVVQDPDALPAPSSSVDRVSPSPGGTPAPVPTGAEASTESQLVSDPTEGKTCTETS--------------REEDEVALAADLEIFLDTLRSMEPPEILRTHRLPRAPRSSYLSMYATLPAIEEDQ-LGPWVLGPGPQEVPSLEEKEEE---EEEEPENPYLSDDEKLQ--RRQEKAGPSPSRDLHPARPTQVSCSPLEMMKKHVAGTKGPHSELGLELQGGSRPTSRLGGSLLFG----------------------------------------------------------------SLVPTAKEASTPEPLGTKLSALLPHGAPGLRKVPGQLPLLCSERSSPTEKLACSLP-----------------------LEGWSPALKTQGKLNTRPGKVIFFSESGCQGSGREVWGDIVDASGWAP--VASIRVVRGCWVLYEEPEFRGQKLVLPEGDMELRTPGTKWSPQ---------------------------------GIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPED-SQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEG-----HGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AL91-1", "uniprot_id": "A0A8M3AL91_DANRE", "id": "A0A8M3AL91-1", "name": "", "aln": "MEKKSSSSRRTLKSLFSRSEVNLSEHEPKTDSNGGSFRLFKWKKKKKSESSEDNPNTDRAESADGDIQDGEEQNKHKTALFGRSKKGKRSYSETDLHKPKGFIGSLTWGRKKKQNRDRVQDLTSNSDISGVKDHISEQEEFDNHKETEQIQACVEAVRSAPEPPCASDQSQSQHVLSDQSTLSEEDAGFMPTAQESKAIPYIDSSDSDAYQTPPDSPNISSDAQAQPDTQYGKLSAQNSITSETSEYYICPGTDMKTAACTDTSTARISHDNVVSQKRSHLEHGEYSNAASLTQESYISRPESTDSSIHESSSLFIPKSPVFSIPESSFSSDPQNPTASIPQVSSSSDPQLSTSSIPESSFSSGPQISTSSIPQSTSTSVPQISTSSIPQSASTSVSQISTSSVPDSSSVSVPQIFISSVPQSSSSSDPQISTSLIPEFSSSSDPQIFTSSILQSTSTSVPQISTSSIPQSSSSSVPQISTSSIHQSSPTSVPQMSTSSIPQGSSSSVPQISTSSIPQSSSSSVPQISTSSIPQSSPTSVPQISTSSIPQGSSSSVPQISISSIPQSSTNSVPHSSTPLVHESSSSYIPQSSTSTMHDSFNSDSTMTQSFSTNTNSAFNLPEDSFSHPADTISYEDSHTTSANVRNKSFIDSNVINSDPSSPTTDICESDHVSSKPYVIVSSTLCSSRIKGNRIKTDRKPSSSNTNVSESDVTVHSTADSGSREETPPESSCVTISKESHATDNYSSLAYATDSEKHNPAQPVLPENESNIPLSPSARAYTIIKSTKVVTFDLSGPSDHISFDHSHRSLSNNEPDSDVETLTEILDHEGQDNNQTDTDSSAKASSGFPNHTIPSMSLTSYPPLHLDVSDQMFSSQSLKAKTEKQQKTSRACEDQEKCLQDASITEDTKLQKVSEECGMLKKKEDDVLIETEKQQKTFRACEDQEEYPQHASTQSLDPVDRINQNKSNAEITEATTLHKALEKVAMVEEKRDELYTKMEKQQKTFRAYEDQEGYLQDASTQRFTEKSIGESETNAERMTTTDDATSVTEDTKLQKVSEEFAMVKKKEDDVLMETEKQQKTFRAYKDHEEHLKDISAHRFIEKSVDQDKSNAEIKVSTKLHKALEKFAMVEKQRDDLHEETEKQQKTSRTYEDREACLQDASTQRFIEKSVDQNESNAEITEATKPHKALEKVAMVEKKTDELHMGTEQLKTSRAYEDREEYAQDASTQRLESIDQINQNKSNAERTTTRNDAISILDNELNQIIEATKLHKASEDSPMLKKMSNESHMDQISSAVETEACRGAGVLTGQAEPQIPSLSTPKPAIPVHQEHVPEECTPAPPFSELLKVSLTDSSMQSQSHLENLPLPLGLHQYNTEITILEDTAGCKHHSSTDKNTHGGYIDTLSRTLGSESQDCSIEELSGAYSTKQTFTHSNDSKQEEVKADGDTISLWNQISESTSDTERKEETDDLADQTASDCLTPGERIVHATVPSTVIEHNQVLNTVMNSGVSVLNTKLNPPSSPRDGRDDGVVFRKVSLVKNELPEPSRASPELQRRFQALQDKTERSDYTHSYEKAVYTSHFHSPETEVTHYSGGRGREELSLPGERLQIIPTHSQLDPEPALFIVEADDSEVFQAMRVELHHSPTSTEPPLLNSEMDNLVDTLKSMDRPLRQRVQRAPSN------APFSSLPPIEEDAPVSPSITPLSPPFSPVHEPKSMLNGSSGLDFGFNWSSTKDMRSPLTMMKEQQFGDAQNRGLSLPLRASALSSIVMRRSSLNDLSPEDGSAKPLINGASSSSRLENSFFFQPSENGASSRSIFRAASLPDIGSGADRISSAAKSTDSLVGSRFERFSYLTSPSNSLSGIAEASRISVAPFAQSQSAESQSFSHKSTSELYRSLPSETLLKSPPSLSIQRSSSLDGGFLINDNLQVNQKPEPEPERNLLLKYRAFPDAYLTKEKEHGKLNPRPGKMIIYDKPGFTGERIEVRGDVVDATPWEFTDTISVRVIRGGWVFYEKPDFKGEKIALDEGEMELTDPFRPAEEEEEADLQNGGESHGEIVNDGEEQQENKPHRTRKFSIGSIRRAVRDYSVPEISLFPEENAEGKKVTFRDTSEDARIFGFPIKANSIIINAGLWLVFAEPFFQGVPRVLEVGGFPSPSAWGVTHPYVGSLHPLKIGEPRVENLYEPRLVLYEKPYFTGKSREIYSSMRDFLSRADKQQTLFMFSAGSLKVTGGCWVGYEKEGFRGNQYLLEEGEYHDWRVWGGVNSELRSVRVIQSDLSEPQLVLFAMPEQESEQDEERTFDVTEAVADVELFGFGINTRSIQVLSGAWVAYSHVDFSGNQYVLEKGFYNNCGDWGSGDNRICSLQPILTAPSDGPILRNEVLLYSEPDFLGSCRVCHHNQDALPESLMVRSCRVVGGSWVLYGEEKFSGSMYVLSEGDYPNLSSMGLPADSRVRSVRAVPVSFCVPSVSLFGLECFEGREVTIDTQISSMQEEGFNTQFLSVRVNTGCWVLCEHSNYRGRQFLLEPIEITNWLKFSSMSCIGSLYPVRQKQRPFRIRNKQTGHCVSVQGGVEDMKTGRVLVSEQVEGMSDIWLYQDGLIKNKLARSMSLQVMGNVESGAKVVLWTETRVPVQTWSAQMSGAIASLTFPGMVLDIKGGKTYDKEHLVIREENEEQPSQQWELEFV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : .. .:: : ** * . . . : * . *.: :. : . . : : *... : .. . . ... .* ..: . . . :.. . .: . :*. * . :. * .: : .:: .. .*:. * :. :* .* . :: *.:* . . .** : * * .:: . : .:: .: *.. : : **:: : .*:: : . .: . * * . . :. . * . .:: : . . .::. . : : . : :.. . : :*.: * : :. . : ::.* . *. : . * : . ... .:. . ::.*.. . . *: .*: * ..* .* . . :* ::. * . . : ....: . .. . * .. .: :* : . . : : .: . : : . . : . . .* ** .:.: . :: * . : * :::: ::***:**: * *.:* * : :::**.**** :.* : .* * * :. : : * .: :: : . . * :.:. . :*:: . . . .:*** .*::* .:.* :. .: . :: *: : : ..: . * *. . . : :.: . * :****.****:*::.:.* * ** *:.**: * . *:**:** *::**:*:*:*:*: * **::** . : .:**::*.* **..*.****.**. :*: *.: :::: : *::. * :.*****::.:*:*:..* :** * :*: .***.: ****:*:::* * **: **: *:** * * *:* *: .: :: . * .*: : *.***:: **************:********* ** *** :. * *:***::*:.:* :*** : :. : .:*:.*:.**** .* .*::*:****.****..*.***:*::****.*.** ***:*: : ****:: . . . : .:: *:* *:***. ..:* :** *: :**** ****:*: : :*... :::***::*.*::** *.: : *:: :.: *. **: *:*******:*: : :: *:* ****.:.****:: * **:****::****:*: . ******.:*. . :*****::*:: **: * * ::* . *****:***:*:: * * ** *::**:**::* :*****:* ..*:*****:*:*:* **** . * *.* * * :**:***: **::*:*: * ::: ** * :..:", "identical_positions": 382, "similar_positions": 510, "identity": "14.23%" }, { "cls_id": "homologset.agr.HGNC:17296", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6PEE3-1", "uniprot_id": "RIR2B_MOUSE", "id": "Q6PEE3-1", "name": "Ribonucleoside-diphosphate reductase subunit M2 B", "aln": "--------------------------------------MGDPERPEAARPEKGEQLCS----------------ETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWN-KLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETT---DNVFTLDADF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ADQ1-1", "uniprot_id": "D4ADQ1_RAT", "id": "D4ADQ1-1", "name": "ribonucleoside-diphosphate reductase", "aln": "--------------------------------------MGDPERPEAARPEEGEQLCP----------------ETKENEVRSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWN-KLKSEEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVMEIIVDAVKIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETT---DNVFTLDADF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7LG56-1", "uniprot_id": "RIR2B_HUMAN", "id": "Q7LG56-1", "name": "Ribonucleoside-diphosphate reductase subunit M2 B", "aln": "--------------------------------------MGDPERPEAAGLDQDERSSS----------------DTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWN-KLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETT---DNVFTLDADF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P48592-1", "uniprot_id": "RIR2_DROME", "id": "P48592-1", "name": "Ribonucleoside-diphosphate reductase subunit M2", "aln": "------------MASKENIADNMEKFSLKSPSKKILTDSTNNVRKMSIGHEANGQLAKESSTVNGIGKSANSLMEKSVTPFDPSLEPLLRENPRRFVIFPIQYHDIWQMYKKAEASFWTVEEVDLSKDLTDWH-RLKDDERHFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENVHSEMYSVLIDTYIRDPHQREYLFNAIETMPAVKRKADWALSWISSKSANFGERIIAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFAVLMFQHLVQRPKRERIIEIIRDAVAIEQEFLTDALPVNLIGMNCDLMSQYIEFVADRLLVELGVGKIYNTKNPFNFMEMISLDGKTNFFEKKVGEYQRMGVVSNPL---DNVFTLDADF", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q7ZYW0-1", "uniprot_id": "Q7ZYW0_DANRE", "id": "Q7ZYW0-1", "name": "", "aln": "-----------------------------------MNSCTSNTPTVITGYQNG---------------------HKDVDPNSVEDEPLLRENPKRFVIFPIQYPDIWKMYKQAQASFWTVEEVDLSKDLTHWD-GLKSEEKHFISHVLAFFAASDGIVNENLVQRFSQEVQLPEARSFYGFQILIENVHSEMYSMLINTYIRDLKERDYLFNAVQTMPCVRRKADWALQWISDTNSTFGERLVAFAAVEGIFFSGSFAAIYWLKKRGLMPGLTYSNELISRDEGLHCNFACLIYSYLVKKPSVDRVNDIIAKAVSIEQEFLTEALPVNLIGMNCSLMKQYIEFVADRLLTDLGLPKAYCSENPFDFMESISLEGKTNFFEKRVAEYQRLGVMSNVK---DCEFTLDADF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P09938-1", "uniprot_id": "RIR2_YEAST", "id": "P09938-1", "name": "Ribonucleoside-diphosphate reductase small chain 1", "aln": "MPKETPSKAAADALSDLEIKDSKSNLNKELETLREENRVKSDMLKEKLSKDAENHKAYLKS----------HQVHRHKLKEMEKEEPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNADLMNQYVEFVADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQEAGAFTFNEDF", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P49723-1", "uniprot_id": "RIR4_YEAST", "id": "P49723-1", "name": "Ribonucleoside-diphosphate reductase small chain 2", "aln": "------------------------------------MEAHNQFLKTFQK-------------------------ERHDMKEAEKDEILLMENSRRFVMFPIKYHEIWAAYKKVEASFWTAEEIELAKDTEDFQ-KLTDDQKTYIGNLLALSISSDNLVNKYLIENFSAQLQNPEGKSFYGFQIMMENIYSEVYSMMVDAFFKDPKN-IPLFKEIANLPEVKHKAAFIERWISNDDSLYAERLVAFAAKEGIFQAGNYASMFWLTDKKIMPGLAMANRNICRDRGAYTDFSCLLFAHLRTKPNPKIIEKIITEAVEIEKEYYSNSLPVEKFGMDLKSIHTYIEFVADGLLQGFGNEKYYNAVNPFEFMEDVATAGKTTFFEKKVSDYQKASDMSKSATP-SKEINFDDDF", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . . * ** :. .* *:***:* :** **:.:*****.**::*:** .:. :. ::: :*..:**: :**.:**: *::.** ::* .*.:.****** :**::** **::::::::* :: **: : .:* : .** : ** . .: :.**::***: **:* :*.:*:::**..: :****: :*. *.**.* : :*: *:: :* :*. : .*: .** **:.: ::*** :**: : *:***** ** :* * : ***:*** :: ***.****:*.:**: . ::: :.:: **", "identical_positions": 118, "similar_positions": 125, "identity": "28.85%" }, { "cls_id": "homologset.agr.HGNC:17297", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AYH3-1", "uniprot_id": "RNF34_RAT", "id": "Q6AYH3-1", "name": "E3 ubiquitin-protein ligase RNF34", "aln": "------------------------------------------------------------------------------------------------------------------MKAGATSMWASCCGLLNEVMG---------------------------------------------TGAVRGQQAGFPGSTGPFRFTPSSDFPTYPPAATEG--PNIVCKACGLSFSVFRKKHVCCDCKKD--FCSLCSVSQENLRRCSTCHLLQETAFQRPQLMR----------------------------------------------------LKVKDLRQYLLLRNVPTDTCREK------EDLVDLVLCHRGLGS--GDGLDSRSLSSSRSQTSSFFTQSYFSNYTPPSATVS----------------------------SFQGELMDREGTFRSEVLTQVQSELASANTDDEDG---------------------------------------------------------------------------EEDDDDDDDDDDEDDDEQEENLEEQNPGLSKKKARASLSDLSSLEEVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYG------------------------ERMQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99KR6-1", "uniprot_id": "RNF34_MOUSE", "id": "Q99KR6-1", "name": "E3 ubiquitin-protein ligase RNF34", "aln": "------------------------------------------------------------------------------------------------------------------MKAGATSMWASCCGLLNEVMG---------------------------------------------TGAVRGQQAGFPGSTGPFRFTPSSDFPTYPPAATEG--PNIVCKACGLSFSVFRKKHVCCDCKKD--FCSLCSVSQENLRRCSTCHLLQETAFQRPQLMR----------------------------------------------------LKVKDLRQYLLLRNIPTDTCREK------EDLVDLVLCHRGLGS--GDDLDSSSLNSSRSQTSSFFTQSLFSNYTPPSATVS----------------------------SFQGELMDRDGAFRSEVLAQVQSEIASANTDDDD------------------------------------------------------------------------------DDDDDDDDDEDDDDEQEE--EEQNPGLSKKKARASLSDLSSLEEVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYG------------------------ERMQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969K3-1", "uniprot_id": "RNF34_HUMAN", "id": "Q969K3-1", "name": "E3 ubiquitin-protein ligase RNF34", "aln": "------------------------------------------------------------------------------------------------------------------MKAGATSMWASCCGLLNEVMG---------------------------------------------TGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEG--PNIVCKACGLSFSVFRKKHVCCDCKKD--FCSVCSVLQENLRRCSTCHLLQETAFQRPQLMR----------------------------------------------------LKVKDLRQYLILRNIPIDTCREK------EDLVDLVLCHHGLGS--EDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMS----------------------------SFQGELMDGDQTSRSGVPAQVQSEITSANT------------------------------------------------------------------------------------EDDDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYG------------------------ERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BK99-1", "uniprot_id": "A0A8M2BK99_DANRE", "id": "A0A8M2BK99-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------MKAGASSMWASCCGLLNEVMG---------------------------------------------TGAVRGQQPGFGAGAGPFRFAPTAGYSTYPPANSNS--TSLVCQACRQAFSVFRRRYICCDCTKS--FCSLCSVLQENLRRCTTCHLLKGTAFQRSQLMR----------------------------------------------------LRVKDLRQYLMLRNINTDTCREK------EDLVDLVLCHHGAE------------SEDDPDTPSLQSHP--LYSPPPLIEEP----------------------------TSPLSALSPTR----EPISRSNSSESTNQD------------------------------------------------------------------------------------IEDSTSVSLLNLDQTEHTPEVSP-QTRRRARASLSDLSSLDDVEQLTVRQLKEILARNFVSFSGCCEKWELVERVRRLYRENEDNRKSMENVSNPITAVVAYPPPICNGGIGDSCR-TQLS-NDDNLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVIRAVHVFKS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M2B9I4-1", "uniprot_id": "A0A8M2B9I4_DANRE", "id": "A0A8M2B9I4-1", "name": "E3 ubiquitin-protein ligase RNF34", "aln": "------------------------------------------------------------------------------------------------------------------MKAGASSMWASCCGLLNEVMG---------------------------------------------TGAVRTQQPGFGAGAGPFRFAPSAGYSTYPPSSTTSGSAGLACKACGLAFSVFRRKHVCSDCKKS--FCSLCSVLQENLRRCSTCHLLWGTAFQRPRLMR----------------------------------------------------LRVRDLRQYLTLRNINTDTCREK------EDLVDLVLCHLGAELELGEDEEEEEEEEEEADTDSLPSLPRSLSTPPASAARS----------------------------SSQQSALSAAAS-QGEALSRSDSSGTNNQD------------------------------------------------------------------------------------HGDAASVSLLNLESHDDMLEASP-ATQRRARASLSDLAHEDDIESLTVRQLKEILARNFVNFSGCCEKWELVERVHRLYRENQLNRRSMENVSNSLAAVIAYPPPICNGGIGDGVQVAQLGGADENLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z971-1", "uniprot_id": "A1Z971_DROME", "id": "A1Z971-1", "name": "RING-type domain-containing protein", "aln": "MPCESCGVEFTVFRRKRACFDCKRYYCANCIASRRCKRCSVFAQRPLSRTDLLKLKPKDLIFYLQSKHISTEGCLEKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGAIGGISDESKANTDTNSSHLDQWQVLEVNRIEAVEETPTTSAADEILEVTLRSRPAVEGDDSEMGESTQALNVNQRPANPSPAFYPAVPQRTKKVTRRRSDGYLNRRYHSSDDESPVAPGGPGLSLGLSTLSEHPEHGLHPHSHRQSCQRCGKNKTNIRRHVEKMRRHLENSQMSEEDIKRELQEFLTYLEQRTKSVDASDADSHAVSPLSVDAISVAAGGRSPDMPITPTIEFSPTQDEDIRWDDDEGIHVYAAPSDFEPTAGIDSRFVNLEDFEDLKDLEGLTVKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECP-------------------------------AVEKLATDELCKICMDAPIECVFLECGHMATCTSCGKVLNECPICRQYIVRVVRFFRA", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* .. .:::. .. :.: :. *: * . ..: . .... .: : . . :. : . . : .:*... :.:... . .*: :: : : :* . : . .* *: *. :: .*. ::::::.* . : : : . . . : . :. :: :* : * . . . : .* ..*.*: .::* ::*:****:* : *.:.***** **:::* **:: . :.**:***** *:**:******.***.*** :.********::*.*:.*::", "identical_positions": 67, "similar_positions": 129, "identity": "9.17%" }, { "cls_id": "homologset.agr.HGNC:17298", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q4V8D6-1", "uniprot_id": "BRF2_RAT", "id": "Q4V8D6-1", "name": "Transcription factor IIIB 50 kDa subunit", "aln": "MPNGSRCPDCGSSELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRDLRRVRDLCRILKLPLTFEETAVSYYQKAYQLSGIRAARLQKKEVVVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLADLVKSYCSSFKLFQASPSMPAKYVEDKDKMLSRTLLLVELANETWLVTGRHPLPIITAATFLAWQSLRPSDRLTCSLARFCKLANVDLPYPAAS------RLQELLAVLLQMASQLAWLQVLRLDKRSVVKHIGDLLQHRHMLVRMAFQDGTAEVETKQQQPQ----GRGQQEEVGDSTFDLPKRKRP---------ASPALLLPPCMLKPPKRTHTMPPDSVVTGDEDISDSEIEQYLRTPQEVRDFERAQAASRAAMSVPNPP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UAW9-1", "uniprot_id": "BRF2_MOUSE", "id": "Q3UAW9-1", "name": "Transcription factor IIIB 50 kDa subunit", "aln": "MPNGSRCPDCGSSELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNFREVTYSRSTGENEQVSRCQQRDLRRVRDLCRILKLPLTFEDTAISYYQKAYQLSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGTICTLLYADLDLFSGTYMQMVKLLGLDVPSLCLADLVKSYCSSFKLFQASPSVPAKYVEDKDKMLSRTLLLVELADETWLVTGRHPLPIITAATFLAWQSLRPSDRLTCSLAQFCKLANVDLPYPAAS------RLQELLAVLLQMAGQLAWLQVLKLNKRSVVKHIGDLLQHRHMLVRTAFRDGTAEVETQQQQQQQQGQGQGQQDEVGDGPFDLPKRKRR---------ASPTPLLPPCMLKPPKRTHTLPPESAVTGDEDISDSEIEQYLRTPQEVRDFERAQAASQAAMRVPNPP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HAW0-1", "uniprot_id": "BRF2_HUMAN", "id": "Q9HAW0-1", "name": "Transcription factor IIIB 50 kDa subunit", "aln": "MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTMQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASS------RLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQSLVRSAFRDGTAEVETREKEPPGWGQGQGE-GEVGNNSLGLPQGKRP---------ASPALLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTPQEVRDFQRAQAARQAATSVPNPP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8KBY2-1", "uniprot_id": "BRF2_DANRE", "id": "A8KBY2-1", "name": "Transcription factor IIIB 50 kDa subunit", "aln": "--MSKNCPECGSSRVVEDDLYSQKQWVCEDCGSVVSEGLLTTTLSEESHSRAVPFFTSTAAFKKPCRNLVSGFSRLRALCRIFRLSSSMEDASANLFERAYNHPNFLHISLSKKQILAGCCMFHICRQNSWPVFMGTIGYLLDADNYQMGTIYQELTKSLNLQTTQVCITRMLESFCYDFKLAPD--EVEEVFSVAQQRLVDQTSALLELAADTWILTGRRPFPLFLAAVYVAWQSLNPLARMKYSLMKFCKIAKAPEQLWCKSKDTINKRLNELLEVLCKLGRELPWVRPTDIQMNTVTTLVEDILKHRKALLILAVKHYEKQLEETQTSQYSESELSDSKSSVQTQCKSPPDEEDEGCELPPDHWGKRHLFLPPCVRTQKRQKINEAP-LEVTGDEDISDSEIESYIRSEEEIKLFAKARKKICKY-------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .**:***:.:***. ***.* **.***.**:**:****:*:*.: * *.: **. :: .* .: *:* ***:::*. ::*::: :::**. ..: *.**:::.***:: ***:.**: **:* ** ** :. * ::.* *.*:...:*:: :::::* .*** .: : :::::.:* *:*** :**::***:*:*:: **.::*****.* *:. ** :***:*:. . * **:*** ** ::. :*.*:: :: .:*.. : *:*:**: *: *.:. ::* : . .. .* . *. : .. :****: . :: .* *****:*******.*:*: :*:: * :*: ", "identical_positions": 137, "similar_positions": 148, "identity": "31.49%" }, { "cls_id": "homologset.agr.HGNC:17299", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G5E8H5-1", "uniprot_id": "G5E8H5_MOUSE", "id": "G5E8H5-1", "name": "", "aln": "MYGEKKSHLYLWMEHYGYDMPANIYKMYSQPSRKTDDANKKVSVSASRTIKLNGSTGYDTNEQITLITNGS---SLSYPDEIKSASYADPISTKAYTNDSSVYDPGGASSS-TTLYELNSLSEVSKEIITQGESALLRDKEATSEL-KIPSTLQTQTSMSTNTLSLSDLS-SDYQEEQMNKCKLNQMSKLYDDDERTDIQKSYWNVVKKFVRILVSSVAFRIFGIFLVILDVFLVVVDLNVSEKKIYIPLDYRSISLAIALFFLVDVLLRVSVEGRRRYFSDVLNTLDAVVIGVTVVVAVIYALYDKHFLRDIPRLAVLLRPLRLLILIRILQLAHQKRQLERLTRKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSER-AYDPKHFHYRVRRIMIDDHNVPTLEEMLLFSKEVNNWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETPSQNRYVKYFEKLKINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQIIMWQETVFSFCNSRNCMIFHDPETDRAIINVFHCPALYDDVKVKFLSPNLPKYYDDCPFFFWFHTSFIKNNRLYLPRNELDNTHKPKTWKIYGEKFAVEVDFGEN------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4ADC8-1", "uniprot_id": "D4ADC8_RAT", "id": "D4ADC8-1", "name": "", "aln": "MQGVKKSHLYLWMEHYGYDGPASS-RVYSQLSRRRRNANKKVLSSTSKSTKLNGSIGYDGNEETTTFTNGSSIDSMSYQDDMKSSNCMDPTSEKRYGNDSSLYTIDGTLNNGTTLYEMNSLSELSKEVYLN-DSALLRGKEAASELSQVSSTMKTQSSVSTSILSTSDLISEEIQEEQINKCKLNQISKLYDEDEHVDIRESYWSTVKKFVHFLVSSVAFRIFGILLIFLDVFLVAIDLHATEKNIYIPLEYRAISLAIALFFLVDVLLRVYVEGRQRYFSDVLNTLDAVVIGVTVLVAVIYTLYDKQFLRNIPRLAVLLRPLRLLILVRILQLAHQKRQLEKLTRQLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSER-SYDPKRFHYRVRRIMIDDHNVPTLEEMLLFSKEVNDWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKASLYFFGERRTDKSNSSKFQGVETPSQNRYVKYFEKLKTSYQLTLPPKKVLVIKRFTVYSIHGVGKGNGSDLEIQIMMWQETIFSCFNSKNCMIFHDVETDKVIINVFNCPALYDDVKVKFLCPNLPKYYDDCPFFFWFHTSFIRNNRLYLPRSELDNTHKQKTWKIYGPKFAVEVYFEEISSTVMY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6XPS3-1", "uniprot_id": "TPTE2_HUMAN", "id": "Q6XPS3-1", "name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2", "aln": "------------------------------------------MNESPQTNEFKGTTEEAPAKES------------PHTSEFKGAALVSPIS----------------------------------------------------------------------------------------KSMLERLSKFEVED--AENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIR----GDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P53916-1", "uniprot_id": "TEP1_YEAST", "id": "P53916-1", "name": "Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1", "aln": "--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MREEGSELEMEKGFLKWKP--VNLMKKILSLPMKKTKNDIG----LRLDISYILVNLIVCS---YPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFN-FRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIG--WLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECG------GNMTFIFGRDYLTLENDCRIEFTLGTSK--------------SKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLK-------------------RDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. *:: :. . . :**:: :.. * : **: : :* . * * : .* *: .* :*. : *. . . : :: : : . .: : * : : : : : :.: :.: . :. : *:* * :*.... :: . : :: : :* * . * : :*: : . : :: *. .* .. : :: * :: * .: : : **:** : : :: .:*.: :.. :..: : . . ::. : . . .: : : : . ::* . .* : ** :*: * :: ::: . .:: .. . :.: . : :: *: ", "identical_positions": 39, "similar_positions": 147, "identity": "5.76%" }, { "cls_id": "homologset.agr.HGNC:173", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P38444-1", "uniprot_id": "AVR2A_RAT", "id": "P38444-1", "name": "Activin receptor type-2A", "aln": "------MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNAN-WERDRTNQTGVEPCYGDKDKRRHCFATWKN--ISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPE--VYFCCCEGNMCNEKFSYFP-EMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHMMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSGGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCLGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P27038-1", "uniprot_id": "AVR2A_MOUSE", "id": "P27038-1", "name": "Activin receptor type-2A", "aln": "------MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNAN-WERDRTNQTGVEPCYGDKDKRRHCFATWKN--ISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPE--VYFCCCEGNMCNEKFSYFP-EMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P27037-1", "uniprot_id": "AVR2A_HUMAN", "id": "P27037-1", "name": "Activin receptor type-2A", "aln": "------MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNAN-WEKDRTNQTGVEPCYGDKDKRRHCFATWKN--ISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPE--VYFCCCEGNMCNEKFSYFP-EMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1QG01-1", "uniprot_id": "F1QG01_DANRE", "id": "F1QG01-1", "name": "Serine/threonine-protein kinase receptor", "aln": "------MGPATKLAFGVFLISCSSGAILGRSETQECVFYNYNPSLENRGNRSGIEPCVGDKDKRLHCFATWRN--VSGTVEIVKQGCWLDDVNCYDSTECVEKKEDPD--VFFCCCEGNMCNEKFFYNP-NTAPVQTTSNPLTQKPPLFSTLLYSIVPIMGIAAIVLLSFWMYRHHKLAYPPVLVPTQDPGPMPPSPTLVQKPLQLLEIKARGRFGCVWKAQLLNDYVAVKIFPIQDKLSWQNEYDIYNIPGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGLAYLHSDFPGHR-DGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSVSAPEEIVTVVTMVTNVDYPPKESSL-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q24468-1", "uniprot_id": "AVR2_DROME", "id": "Q24468-1", "name": "Receptor protein serine/threonine kinase put", "aln": "MSKYDLLYLTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECN-QTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGLLLYRRRKQAH-FNEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMD--KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFA-GPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYP------STQLLIKNHTNIDDAKESTNCL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :::*:: **. .. : * ** .:: : : .: :* * : ** *:. * :* :.* :**: * :* *:*: . : : :.****:*. **.: * . ..: * . . : . : : ** .: :**:: *: :**::. .** * :*:**** ** **** **:*:* *: ****** :*:* ** .*:::*.:* *:* ***:*:*.**: . : ***::::.:.** *:**::.::* ***:**::**.***:**.::*. : ** **:*:***:********.:***********: *:.**. ************************:********:** ******:.:** : ***.*: **** *:* :*:*:::** ** ** ** * : *: *.*: ::*:*:******:******:.*: **..*::: . . ::. **:* . :.:. ", "identical_positions": 216, "similar_positions": 153, "identity": "40.99%" }, { "cls_id": "homologset.agr.HGNC:1730", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9UQ88-1", "uniprot_id": "CD11A_HUMAN", "id": "Q9UQ88-1", "name": "Cyclin-dependent kinase 11A", "aln": "--MGDEKDSWKVKTLDEILQEKKRRKEQEE-----------------KAEIKRLKNSDDRDSKRDSLEEGE-------LRDHCMEITIRNSPYR---REDSMEDRGEEDDSLA------IKPPQQMSR--------KEKVHHRKDEKRKEK-----------WKHARVKE----REHERRKRHREEQDKARREWERQKRREMAREHS--RRER-------DRLEQLERK----RERERKMREQ-----------------QKEQREQKERERRAEERRKEREARREVSAHHRTMR--EDYSDKVKASHWSRSPPRPPR--------ERFELGDGRKPGEARPAPAQ--KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE-GSTSEESEEEEEEEEEEEEE-TGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD----SGESEEAEEEVGEG-----TPQS---SALTEGDYVP-DSPALLPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT-----FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNQGASAAGPGFSLKF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P24788-1", "uniprot_id": "CD11B_MOUSE", "id": "P24788-1", "name": "Cyclin-dependent kinase 11B", "aln": "--MGDEKDSWKVKTLDEILQEKKRRKEQEE-----------------KAEIKRLKNSDDRDSKRDSLEEGE-------LRDHRMEITIRNSPYR---REDSMEDRGEEDDSLA------IKPPQQMSR--------KEKAHHRKDEKRKEKRRHRSHSAE-GGKHARVKEKE--REHERRKRHREEQDKARREWERQKRREMAREHS--RRER-------DRLEQLERK----RERERKLREQ-----------------QKEQREQKERERRAEERRKEREARREVSAHHRTMR--EEYSDKGKVGHWSRSPLRPPR--------ERFEMGDNRKP---------------VKEEKVEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPESRFDRD----SGDSEEGEEEVGEG-----TPQS---SAPTEGDYVP-DSPALSPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMT-----FSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNQGASAAGPGFSLKF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M3BC62-1", "uniprot_id": "A0A8M3BC62_DANRE", "id": "A0A8M3BC62-1", "name": "Galactosyltransferase-associated protein kinase p58/GTA", "aln": "--MGDEKETWKVKTLDEILQEKKRRRELEE-----------------KSDPKRIKNADDRELKRDTPEEGE-------LRDHRMEITIRNSPYT---REDSTEDRGEEDESLA------IKPPQQMTR--------KDKNYHRKEEKRKDKRRRRSHSAEGAEKHPRTKDKEKERENERRKRQWHEDNKARQDYERQKRRDQARAHS--RRERSDTLTQRDRLEQLERK----RERDRKLREQE----------------QREQRELEERERRAKERRKDRDTRRDVPISHHRVAPAEEYTDKARLRHRSRSRSRSPVRL------QRETKAESSEPRR------------AVREGKVD-KDPLSDLQDISDSERKTSSP-GSSLGSGSGSEAEEDEDNEEEESSSQTEGDEEGESGSESEGSEHSGGALSDEEPSE-----EEEEGEEEEERENGNHIPPVPESRFDHDSEVSAEEEEEEEEEVEEEEAVDVTPQSHAPSATPEERYIP-ESPPVSPVELKKE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLRGVRHLHDNWILHRDLKTSNLLLSHKGILKIGDFGLAREYGSPLKPYTPVVVTLWYRSPDLLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKIFKDLGSPSEKIWPGYSELPAVKKMT-----FTEYPYNNLRKRFGALLSDQGFDLMNKFLTYCPAKRISADEALKHEYFRESPLPIDPSMFPTWPAKSEQ-QRVKRGTSPRAPEGGQDFSQLGDDD---------------------------LKDTGFHLTT-ANKGASMAGPGFSLKF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P46892-1", "uniprot_id": "CD11B_RAT", "id": "P46892-1", "name": "Cyclin-dependent kinase 11B", "aln": "-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSEKS----RTTSWLFQSH----------------------EVTEILGRVKKNRKK----------------------LVKGLHRAGPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEKNYLP-DSPALSPIELKQE-----------------LPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPLTSIREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMK---QPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLTHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDIGTPSEKIWPGYSELPAVKKMT-----FSELPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQ-QCVKRGTSPKPPEGGLGYSQLGDDD---------------------------LKETGFHLTT-TNDGAVSCRPWCSLLF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VPC0-1", "uniprot_id": "KP58_DROME", "id": "Q9VPC0-1", "name": "Serine/threonine-protein kinase PITSLRE", "aln": "MVNSSGSEDGQLRSPNDVHYHSRGEEDEHEGDADALYIQPPQASRESGSGPRREKKKHSRERRRHKERDDVGGAALALERDHRYDYRSREEHYHHHQRERSSNAAAAYAKHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKERERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDDIEVIRDDDDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQEQPEEKPEEKLKEKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPGFSLKF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : . .:. : . * : ..: : : .* :. :.* * * :* **:* *.:*****************************:*:******************:**:*****:**.********************:***:************** *.*:***** * *** .* *******************:* ****:************:* **.:*** ***:*:*** : ***. *:*******.*:* *****:*:**::*::**::*:*.*******.:**.**:* *:* * .:***:* *: *:.*:: :*** * :*:.*: .*** :*:* ***************** :.:**:.*.** :.*** *: .*** *.: .. * ** *", "identical_positions": 258, "similar_positions": 93, "identity": "27.1%" }, { "cls_id": "homologset.agr.HGNC:17300", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZY89-1", "uniprot_id": "D3ZY89_RAT", "id": "D3ZY89-1", "name": "Transcription initiation factor TFIID subunit 8", "aln": "MFTELFYKAGPQAPPFATSPPHNYKSRRALRSRTLRESKMADTAT---GPGGSGTRPGN-KQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPS-------ELEIQQMEETDSSEQDEQTDTENIALHISTDESGAEKENTSVLQQNSSLSGSRNGEES-TIDNPYLRPVKKPKIRRKKLTRKRVLESLTISFHSPSCRSRERNQPAGAALSWTLPTLETRARYFPSWCSWFSPLQFACVIVPSLSEVVLFNCEQTIYVFSTELERQKKI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EQH4-1", "uniprot_id": "TAF8_MOUSE", "id": "Q9EQH4-1", "name": "Transcription initiation factor TFIID subunit 8", "aln": "---------------------------------------MADTAA---GPGGSGTRPGS-KQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPS-------ELEIQQMEETDSSEQEEQTDTENNALHISTDDSGAEKESASVLQQSSSLSGSRNGEES-VIDNPYLRPVKKPKIRRK--------KSLS--------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7Z7C8-1", "uniprot_id": "TAF8_HUMAN", "id": "Q7Z7C8-1", "name": "Transcription initiation factor TFIID subunit 8", "aln": "---------------------------------------MADAAAT-AGAGGSGTRSGS-KQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPS-------ELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEEN-IIDNPYLRPVKKPKIRRK--------KSLS--------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P0T2-1", "uniprot_id": "TAF8_DANRE", "id": "Q6P0T2-1", "name": "Transcription initiation factor TFIID subunit 8", "aln": "---------------------------------------MADSVMMGSGSLNSGSRSGSSKTCTSPTENYQLARRRTLQVVVSALLTECGFDSAEKAVVETLTEMMQSYITEVGRCAKANCEHTARSTPTLSDVVITLVEMGFNVDTLPVYAKRSQRMVITAPPITNAPVVPKSLTAGQKRTHPAHIPSHFPDFPDPHTYIRTPTFREPVSDYQVVREKAASQRRDVERALTRFMAKTGETQSLFKDDISAFPLIAAKPSPIPYLSALLPS-------ELELQSLEETDSSEQDDQMDNDNNTSHIMQDDSGADKENE-VLPPGGVVPSGKANEEN-MIDNPYLRPVKKPKVRRK--------K-----------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VWY6-1", "uniprot_id": "TAF8_DROME", "id": "Q9VWY6-1", "name": "Transcription initiation factor TFIID subunit 8", "aln": "---------------------------------------MEKVEA----------------VTVSNVDPY----RRILNKVVSQLLLDKGAGQASNHSLETLTQMLQALIWEIGNSAHNYCELSGRTMPTVGDVSLALINMGISISNLDPYMRKETHVPIPLPPQQTQQRPLSLLQAGIKAPHPHYVPSYFPPMPDPHAYIRTPTHKQPVTEYEAIREKAACQKRDIEKALTKFLCKTTETNNLFPTEDNMFPLIACKPAFPPYAAALNPTDQVFDFEELEYHYLVANRTEDEPSKDDGEEGDSENEEMDGDKSKEEKPELDIKPNSNTNKAILENPNIDNPYLRAATLPKRSKNCPTPG-TMPSRSLATTAPTIRTPSTLEITKTNL-----------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . .. .: * ** *: *** ** : * .*.: :****:*:*: * *:*..*: ** :.*: **:.*: ::*::**:.:..* * ::. :: *. ** . . * ** : .** ::**:** :****:**:***.::**::*: :*****.*:**:*:***:*:.** **:.** : . *****.:* ** :** *: *** : : . :.:: .: * :: . :.. .**. * .: *. *******... ** :: ", "identical_positions": 104, "similar_positions": 96, "identity": "23.27%" }, { "cls_id": "homologset.agr.HGNC:17301", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QXV0-1", "uniprot_id": "PCS1N_MOUSE", "id": "Q9QXV0-1", "name": "ProSAAS", "aln": "MAGSPLLCGPRAGGVGILVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLVETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPA--AAPRPRPPVYDDGPTGPDVEDAGDETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRSVDQDLGPEVPPENVLGALLRVKRLENPSPQAPARRLLPP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9QXU9-1", "uniprot_id": "PCS1N_RAT", "id": "Q9QXU9-1", "name": "ProSAAS", "aln": "MAGSPLLCGPRAGGVGLLVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLAETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAPAAALRPRPPVYDDGPTGPDVEDAADETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRAVDQDLGPEVPPENVLGALLRVKRLENSSPQAPARRLLPP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UHG2-1", "uniprot_id": "PCS1N_HUMAN", "id": "Q9UHG2-1", "name": "ProSAAS", "aln": "MAGSPLLWGPRAGGVGLLVLLLLGLFRPPPALCARPVKEPRGLSAASPPLAETGAPRRFRRSVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRVWGAPRNSDPALGLDDDPDAPAAQLARALLRARLDPAALAAQLVPAPVPAAALRPRPPVYDDGPAGPDAEEAGDETPDVDPELLRYLLGRILAGSADSEGVAAPRRLRRAADHDVGSELPPEGVLGALLRVKRLETPAPQVPARRLLPP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******* ********:********:* **:*.********.*****.**.**.:* *:**:*************************************************.**:** ***.*. *********************************. ** ***********:***.*:*.*******************:**::.*...*******:.*:*:*.*:***.************..:**.********", "identical_positions": 214, "similar_positions": 38, "identity": "82.31%" }, { "cls_id": "homologset.agr.HGNC:17302", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z0J8-1", "uniprot_id": "NEGR1_RAT", "id": "Q9Z0J8-1", "name": "Neuronal growth regulator 1", "aln": "-----------------------MVLLAQGACCSNQWLAAVLLSLC----SCLPAG-----------------QSVDFPWAAVDNMLVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSV-DPRVSIST-----LNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRT-MQVHLTVQVPPKIYD-ISNDMTIN-EGTNVTLTCLATGKPEPAISWR----HISPSAKPFE---NGQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVVVNFAPTIQEIKS-GTVTPGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFS---------TRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP---PST-------------------------------------------------------AQYGITGSACDLFSCWSLALTLSSVISIFYLKNAILQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80Z24-1", "uniprot_id": "NEGR1_MOUSE", "id": "Q80Z24-1", "name": "Neuronal growth regulator 1", "aln": "-----------------------MVLLAQGACCSNQWLAAVLLSLC----SCLPAG-----------------QSVDFPWAAVDNMLVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSV-DPRVSIST-----LNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRT-MQVHLTVQVPPKIYD-ISNDMTIN-EGTNVTLTCLATGKPEPVISWR----HISPSAKPFE---NGQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVIVNFAPTIQEIKS-GTVTPGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFS---------TRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP---PST-------------------------------------------------------AQYGITGSACDLFSCWSLALTLSSVISIFYLKNAILQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7Z3B1-1", "uniprot_id": "NEGR1_HUMAN", "id": "Q7Z3B1-1", "name": "Neuronal growth regulator 1", "aln": "---------------------MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAG-----------------QSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSV-DPRVSIST-----LNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRT-MQVHLTVQVPPKIYD-ISNDMTVN-EGTNVTLTCLATGKPEPSISWR----HISPSAKPFE---NGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKS-GTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFS---------TRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP---PST-------------------------------------------------------AQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3B3I9-1", "uniprot_id": "A0A8M3B3I9_DANRE", "id": "A0A8M3B3I9-1", "name": "Neuronal growth regulator 1", "aln": "---------------------MDIMIAVQDACVSGQWLTAIILSLCCFLPSCLPAG-----------------QTVDYTTSSES-VVSRQGDTALLRCYLLDGISKGAWLNRSSIIYAGNDKWSG-DPRVSIVSNV---GDKHEYSLQIQKVDVTDEGVYTCSIQSERNLHP-KLIQLIVKVPPKIYD-ISSDITVN-EGSNVSLICAASGKPEPKISWR----HISPSARKYE---SGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPAIHEMKS-HGVRPGQVALLRCEAAAVPSPVFEWYKGEKRINMG-QGIVINNLS---------SRSVLTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTSAVSSPAS--------------------------------------------NPAMYGSTGGAEVLLACWYLILALSSLVTVY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P15364-1", "uniprot_id": "AMAL_DROME", "id": "P15364-1", "name": "Protein amalgam", "aln": "-----------------------MAR--LRLLIGLIFCLAISLDSVLS---APVIS-----------------QISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAE-NTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLL---AEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHEVANTASSS-----GTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIPVPSLS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q24372-1", "uniprot_id": "LACH_DROME", "id": "Q24372-1", "name": "Lachesin", "aln": "-----------------------MWRPSISNCVWSTLLLAIFVQQTLAQ-RTPTIS-----------------YITQEQIKDIGGTVEFDCSVQYAKEYNVLFLK----TDSDPVFLSTGSTLVIKDSRFSLRYD----PNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISD-NSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATY---VGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATAD-----EYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACG---------------------------------------------------QAYIAGAEDVSATSFALVGILAALLFAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IP70-1", "uniprot_id": "Q8IP70_DROME", "id": "Q8IP70-1", "name": "", "aln": "MAMAGPHRLPRPHTRRRFRLQAEFNVRQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQ-NSRISLTYN-----DHRSWYLHIKEVEETDRGWYMCQVNTDPMRSR--KGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKARGYPEPYVMWRREDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVEEWRDGAQGNNAGNNGDNNQTPVRNPPGAFHNSAGSLAQHNLLAKIMLGIKTQSFGIFKRLSSSLPLAAGQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVVNNDTAAECWETRSHCVSESNNNNNSRITQRPPMWARHLRIFHIAHTPCGASTQYQRLCERQWQWQRLWQWQCQWKWQHQWQWPMLICIVILAGCFVRWLPMLLHFIGRHIGTFSISATHRQHLMCTFWDNRGNKVVAKNTTPARPSTFEMLCSRMFSR", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : . : . : ..:. . : * .: . : ::*:.:: :* * * *.: . * : ** * : : . : ** :: : * * * * * : * * * : : . . * * *.*. : :.: *:* * : . :.* . *.. * . : . . . * : : :* * * * * :* ::. : * * ", "identical_positions": 39, "similar_positions": 68, "identity": "5.74%" }, { "cls_id": "homologset.agr.HGNC:17303", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5VWG9-1", "uniprot_id": "TAF3_HUMAN", "id": "Q5VWG9-1", "name": "Transcription initiation factor TFIID subunit 3", "aln": "-MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPG----SKDAE--ERKEYIPDYLPPIVS-----SQE-EEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP-----------------------LDSPEAE-ELPAMKRPRLLSTKG-------------DTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------------------------------------------------SKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKI---------------SKETIQVKQ-IQTPPDAGKLNSENQPKKAVVADKTIEASID----------------AVIARACAERE--PDPFEFSSGSESEGDIFTSPK-RISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG-----TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKE-----------------------------------------------------------------------------KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP---------------------------------------KVKLKDGLVRK-EKEKHKDKKKDREKGKKDKDKREKEK---------------------VKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKE-------------------------------------------------------------------------KVKEKEKKKDKKEKKKKKEKEKEK---KEKEREKEK---------------REREKREKEKEKHKHEKIKVE----------------PVALAP----------------SPVIPRLTLRVG-------------AGQDKIVISKVVP------APEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAP-VPLPLLAQAAAGPALLPSPGPAASGA-SAKAPVRS------------------------------------------------------------VVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTAPPEEMQWFCPKCANK-KKDKKHKKRKHRAH-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5HZG4-1", "uniprot_id": "TAF3_MOUSE", "id": "Q5HZG4-1", "name": "Transcription initiation factor TFIID subunit 3", "aln": "-MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDDVGEAFQLMGVNLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPG----SKDAE--ERKDYIPDYLPPIVS-----SQE-EEEEEQVPTDGGTSAEAMQVPLEEDDEMEEEEVINDENFLGKRP-----------------------LDSPEVE-EMPSMKRPRLLSTKG-------------DSLDVVLLEAREPLSSINPQKTPPVLSPVRVQDRADLAPPSPQPPMLAPFAKSQLPIAKPLETKSFTPKTKTKASSPGQKTKSPKAALSPARLGSPIRSPKTIPKEKKSPGR-------------------------------------------------SKSPKSPKSPKIVAHVPQTPVRPETPNRTPSAMVVEKT---------------VKETIPVMKPTQTPPEVVKLNIEMQPKKPVVTDKTIDDSID----------------AVIARACAERE--PDPFEFSSGSESEGDTFTSPK-RISGSECATPKASTSSNNFTKSLATPLPLSSGTSSSDNSWTMDASIDEVVRKAKLG-----APSNMPPTFPYISSPSISPPTPEPLHKGYEEKAKLPSSVDVKKKLKKELKTKLKKKEKQRDRERERERNKERSKEKDKMRERE-----------------------------------------------------------------------------KEKEAGKELKYPWRELMKDEDSDPYKFKIKEFEDIDAA--------------------------------------KVRLKDGIVRR-EREKHKDKKKDRERSKREKDKRERER---------------------LKEKNREDKIKAPPTQLVLPPKEMALPLFSPS-AVRVPAMLPAFSPMLPEKLFEEKE-------------------------------------------------------------------------KPKEKERKKDKKEKKKKKEKEKEKEK-KEREREKER---------------REREKREKEKEKHKHEKIKVE----------------PVIPAP----------------SPVIPRLTLRVG-------------AGQDKIVISKVVP------APEAKPAPSLNRPKTPPPAPVPIP--VRVSPTP-LQPPLLTQAAVCPALMPSPAPALSGIGSAKAPVRS------------------------------------------------------------VVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMAAPPEEMQWFCPKCANKIKKDKKHKKRKHRAH-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5RH27-1", "uniprot_id": "Q5RH27_DANRE", "id": "Q5RH27-1", "name": "Transcription initiation factor TFIID subunit 3", "aln": "-MCESFARSLLRVSVAQMCQAVGWDAVQLSACDLLSDVLERYVQQLAKSCHRYSELYGRTDPGLSDVDQAFGFLGVSIAELEDYVNNVEPIGYPQTIPQFPISKSSVLQFPAAGFDTDARDALRGERRDYIPEYFPPLVS-----LQEDEEEEEPVPADMGTSAEAMQVSMGEEEDGEEEE--NDENWLSRHD-----------------------GQSPRPEGLLPAAKRPR-LSTKP-------------GVSPEWSYEPREPLSSLNSQHMPHSPSPP-------LSPELPRPPVAPPTPGHKPKLPSPSPAR-------QKNKSPKRGGAAPTGVLGRPLTLTPPKTNQKAGK--RSPGM-------------------------------------------------PKSPRSPRPS-------SAPLG--IAGRGWPGPLADDS---------------SRD--------------------GQFKCNDTDDKDIENSIA----------------AVIARACAGEDGTSDPFAYDSDSDSEGPHPPKPVPKHTLSHIKPPQALTS-----KHLLPPVPP---LLNPPIRWTMDDSIDEVIRKASQGQKPIQPPSLSPLEPPYLSSPSDSPPTPPPPLKLTQERKDSPTGNLLKKKLKKDIKTKLKKKDKERLKEKGKEKGK--NKEKNKEKKRE-----------------------------------------------------------------------------KERGQVEENKMPWPELSLVVGGE-------------------------------------------------------ERRDGIGGKKEKDKHKDKKKDKEKGKKEKEKRDKGK---------------------ERGK-EEKRISQGTKDIAIAVAGATSPLFSPQTCLRIPSMLPPLPPILPDKLFPHPKDI-----------------------------------------------------------------------KSKDKDKKKDKKEKKKKKEKEKDREKEREKEREKERT------------KEKERDKEEKKKDKEKKEKTKEKEKDKPKLEKTSLMAEIPPAVPP----------------SPVIPRLTLRVG-------------AGQDKIVISKVVP------DTEPTPPPPRTPVARMGPGARIRPPPVLPPPAPPPATPPPRPPPVLPPPPPPAAPIQTPPNQAKARGCS------------------------------------------------------------VVTETVSAYVIRDEWGNQIWICPGCNKADDGSPMIGCDECDDWYHWPCVGLLAAPPEDQSWFCIKCAGK-KKDKKTKKRKRKAH-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V4D4-1", "uniprot_id": "Q9V4D4_DROME", "id": "Q9V4D4-1", "name": "", "aln": "MMADRYASDLALVVVAQITQTIGYSCTLSAPLELLQDILQKFVQEFARDMHRHMEHANRIEPNLKDARLSIKNLSINVQELLDYIGNVEPVGFIRDVPQFPIGKSVNMNFLKPG------SAETLTRPVYIFEYLPPMQDPELREIPADVQKEFSEKQEFCSKAEYSSTNAADKLGAKHIDSISPNTVINFRSNAFELDVGSSVREMSSVVMTTGGFISPAIEGKLPEDIIPDIVEKFLGLDAPFSPTIIVNSLQKSPQLALSDRDKTVNPRKIIPSETKIFKQNAALLTSGHSESSIIYASNNHTMLTVTTPKKNRKQKHDLICEPGQSELLTNPFEKAQEKSQRKALKMYKQTSKNQRDSSINQIQNMKKLKKKFNRGSFDPNKKHLEKIFKKQSKLKQNDLQLDIDEKHFLQNSQTTSGLAIKANSNENALQADIPSQPPTVTSQIENNFRNSIYPVQPSVIQQTQVLLAEKKSGSEPERSKLDIFKKISKPRTPRPDIGATLVPPGTGVSVFGSTMTPSALISLPSGTTITPTPSLGLNSENKNVPSMKINPCNIFDGTIPLTKAGVEMSIIDSPKPKKRGRKPGGKNVIKQTNVVSQPLINKVERKKSSQAITLPLSSSPMIITQSSLNVSPPTEPLNLCNTEQPSNNFLSNLYAKEKKDRKKYKSLPENVMQLDKSCSPEKASTLHNSIRPTKQNNDVQCSDKFVTISNALSNASIYPGIQTGMVPLLPLLQFPPRPGLIPTGPGLFPAVTGLVGFGNHGNRIPISPFIDYPGPEESVADTVRCPPIKDSPVTDSDQFLSRSSTQTDLQMDRNYCNVAPLVPDSMKFAECKSVSCASTILENPSAQATSKINTKPLLEASGNPDDPIEVSDDSDESMHNRQMVQRKTPISSPTYVKTSFAELNPSSFTSAASNGEEKSKMDLRNIVSLSSNEPLKKFKKLVKQSFPDVKSVPHTPASHSSFPQFNLPNFMGGDKFSLAGGADLIPLSRVSDSEYSSKIVPFSSLGGTIPNQIKISEEHNIFSTFSNYEDITITPTGLTSLEPKMRKHHKKLKKVKEGKNKKKKEKKDKSKKADQIGLPSFKSDRKIKANDKRQKKEKKKDKDKQILVHIPDDTEEFDKVPLANNDEPVLKSSSMTINPSLGAATSGISPNQIPKLTLKLSGKSTLFSSSEKEMTDAGKLKQTTILSSENKKRERDNSPELARFSPLVTGPPKNKQSETLHLGNSSTAVLPVPSPVAVRAVQLPVSQTSSNSAGWLSNPNNSNTASSTLSASSVLLPQQLMLAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSSYVDAEGNRIWICPACGKVDDGSAMIGCDGCDAWYHWICVGITFAPKDNDDWFCRVCVTKKRIHGSEKKKRRNKKK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P35435-1", "uniprot_id": "ATPG_RAT", "id": "P35435-1", "name": "ATP synthase F(1) complex subunit gamma, mitochondrial", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGTGSLALYEKAEIKGPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKNDMAALTAAGKEVMIVGIG----------------------------------------------------EKIKSILYRTHSDQFLVSFKDVGRKPP------------------------------------------------------------------------------------------------TFGDASVIALELLNSGYEFDEGSIIFNQFKSVISYKTEEKPIFSFSTVVAAENMSIYDDIDADVLQNYQEYNLAN------------IIYYSLKESTTSEQ-------------SARMTAMDNASKNASDMIDKLTLTFNRTRQAVITKELIEIISGAAALD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .::: : : ... . . . . * . .. . : .: . .. . . . :. : : .. . . * ... : .: .:. : : : . : : ", "identical_positions": 2, "similar_positions": 49, "identity": "0.14%" }, { "cls_id": "homologset.agr.HGNC:17304", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91WQ5-1", "uniprot_id": "TAF5L_MOUSE", "id": "Q91WQ5-1", "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L", "aln": "---------------------------------------------------------------------------------------------------------------------MKRVRTEQ-VQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAE-------PQQYEVQFGRLRSFLTDSDSQYSREVMPLLYPLFVYLHLN---LVQSGPKSTVESFYSRFHGMFLQ-----NASQKDVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDN---NTALCKVLAVHIHLDVQPAKRTDYQLYAS----GGSSRTENS-------------------------------------------------------------------------SLEPPEVPSPILQNEAALEV------------------------------LQESIKRVKDG---------PPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSE----PHHVDTSRIRLACDTLEEEENEEDNTGTEMKI----------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGH-TDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCNTPADG-----------------------------SSGELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0M2M1-1", "uniprot_id": "A0ABK0M2M1_RAT", "id": "A0ABK0M2M1-1", "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L", "aln": "MFSECGRGAGRGGRGGDAGEGPRASGSFARARARLCEVPASSRARARGLERPRTWRPRLHAPGDPAAPPGALARSQLCELTRALGGSGQRTDGSRRLPPGDAARRTSQALWLRRREVMKRVRTEQ-VQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAE-------PQQYEVQFGRLRNFLTDSDSQYSHEVMPLLYPLFVYLHLN---LVQSGPKSTVESFYSRFHGMFLQ-----NASQKDIIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDN---NTALCKVLAVHIHLDVQPAKRTDYQLYAS----GGSSRSESS-------------------------------------------------------------------------SLEPPDVPNPILQNEAALEV------------------------------LQESIKRVKDG---------PPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSE----PHCVDTSRVRLACDTLEEEESEDDDVGTEMKI----------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGH-TDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCNTPADG-----------------------------SSGELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75529-1", "uniprot_id": "TAF5L_HUMAN", "id": "O75529-1", "name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L", "aln": "---------------------------------------------------------------------------------------------------------------------MKRVRTEQ-IQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQAE-------PQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLN---LVQNSPKSTVESFYSRFHGMFLQ-----NASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQSDN---NTALCKVLTLHIHLDVQPAKRTDYQLYAS----GSSSRSENN-------------------------------------------------------------------------GLEPPDMPSPILQNEAALEV------------------------------LQESIKRVKDG---------PPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE----PHQVDVSRIHLACDILEEEDDEDDNAGTEMKI----------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH-TDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG-----------------------------SSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AB32U277-1", "uniprot_id": "A0AB32U277_DANRE", "id": "A0AB32U277-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------MKRVRTEQ-IQYAVTQYLKRRQYIDTDGSMKG-AKLSQTAEEMAASLTVQTESSCANVVSAAPCQAD-------PQQYENQYSRLRSFLQEAEGPLVKEASSVLFPLFLYLHLH---MARCGLKGALDSFYSRFHSLFQQ-----DPEQKAIVDLLRGALTLQDVTTNPKLCALLDHKYVVYLTDQAYSYLLRYLQSED---NSAICWVLTAHLQVEVTAAQRTDYQLYGAGVGTGNTSSSSSSTWASV----------------------------------------------------------------DGSEGAERLEVPAGLPQNEAALEN------------------------------LQDCIKRVREG---------PPSLTTVCFYAFQHTEQLLNTAEVSADSRLLAAGFDNSAVKLWSLRARKLKAG----PHRADVSKIRLACDVLEEEADDEDASGSEIKT----------------------------LRGHSGPVYRTAFLTDASGLLSCSEDSTVRYWDLKSFTNTVLYRGHAYPVWDVDVSPCSLYFSTASHDRTARLWSFARTYPLRLYAGHLSDVDCVKFHPNSNYIATGSTDKTVRLWSTQQGASVRLFTGHRGPVLTLAFSPNGKYLASAGEDQRLKLWDLASGGLFKDLRGH-TDTISSLSFSQDSSLVASASMDNTVRVWDIRNAHGSAPTDG-----------------------------CSSELIGQYTGSTSNILNVQFMACNLLLVTGTAMEKQEQ", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P38129-1", "uniprot_id": "TAF5_YEAST", "id": "P38129-1", "name": "SAGA complex/transcription factor TFIID complex subunit TAF5", "aln": "------------------------------------------MSQKQSTNQNQNGTHQPQPVKNQRTNNAAGANSGQQPQQQSQGQSQQQGRSNGPFSASDLNRIVLEYLNKKGYHRTEAMLRAE-SGRTLTPQNKQSPANTKTGKFPEQSSIPPNPGKTAKPISNPTNLSSKRDAEGGIVSSGRLEGLNAPENYIRAYSMLKNWVDSSLEIYKPELSYIMYPIFIYLFLN---LVAKNP-VYARRFFDRFSPDFKD-----FHG--SEINRLFSVNSIDHIKENEVASAFQSHKYRITMSKTTLNLLLYFLNENESIGGSLIISVINQHLDPNIVESVTAREKLADGIKVLSDSENGNGKQNLEMNSVPVKLGPFPKDEEFVKEIETELKIKDDQEKQLNQQTAGDNYSGANNRTLLQEYKAMNNEKFKDNTGDDDKDKIKDKIAKDEEKKESELKVDGEKKDSNLSSPARDILPLPPKTALDLKLEIQKVKESRDAIKLDNLQLALPSVCMYTFQNTNKDMSCLDFSDDCRIAAAGFQDSYIKIWSLDGSSLNNP----NIALNN---------------NDKDEDPTCKT----------------------------LVGHSGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLISGGADHTVRVWDLKKATTEPSAEPDEPFIGYLGDVTASINQDIKEYGRRRTVIPTSDLVASFYTKKTPVFKVKFSRSNLALAGGAFRP----", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VCN9-1", "uniprot_id": "TAF5L_DROME", "id": "Q9VCN9-1", "name": "Protein will decrease acetylation", "aln": "---------------------------------------------------------MSLPSASNHAHAASPVYSNSNNNKSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYG----PMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRG---HVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTLN---------------------------------------------TRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAELS--------------------KLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDH-SASISSLSWSTHNRHLATACSDGTLRLWDIKKLSPMSDNSSAGS-----------------------SSSATTNRVLTVNSSCQRLVDVFYGTSKTLYCIGT-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : ::. . . : :. . : :: . * . *: . : :: *: :* : . * ** : :: * :: : : . ** : . : :*: : :: :. .: . .. . ... . : : : * *: *. : : : : . .: :. ... . ***::* :::*.* . . ::. . * * ** * . * .. : * *:* ::* * . . *:.* :*:* :. ** . *. :.*:* :***** : :.* ::*** **:** ****. *: ***:*:: *:* . * :*:* . .* ::..*:*: *::..*: :.::*:.:* :::.* . * **::* .. : :. * ::*:**::. . . : : : . :..* : .: * ", "identical_positions": 85, "similar_positions": 170, "identity": "9.41%" }, { "cls_id": "homologset.agr.HGNC:17305", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B5DF37-1", "uniprot_id": "B5DF37_RAT", "id": "B5DF37-1", "name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "aln": "MHSSTGAMSEREERRFVEIPRESVRLMAESTGLE-LSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEVLPLRPAREGELYFPEDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLIRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALG--WKAVERVLYPHLPTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQ----AAEPNRGGLGGRGYRPAEDLPWDSLLLQESPPGGGSEPGFGSGLLLPSGVAG-SEDPS-SLTLADIYRELYSFFGDSLATRFGTGQP----APTAP-RPPGDKKEPATTP---DSVRKMPQLTASAVVSPQGDESPCG---GTLAAAN--ATSESRP---LPRVHRARGAPRQQGPGAG-TRDVFQKSRFAP--RGAPHFRFIIAGRQAGRRCRGRLFQTAFP--APYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8R2K4-1", "uniprot_id": "TAF6L_MOUSE", "id": "Q8R2K4-1", "name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "aln": "-------MSEREERRFVEIPRESVRLMAESTGLE-LSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPLRPAREGDLYFPEDREVSLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLIRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALG--WKAVERVLYPHLPTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQ----AAEPNRGGLGGRGYRPAEDLPWDSLLLQESPPGGSSETGFGSGLPPPSGVAG-PEDPS-SLTLADIYRELYSFFGDSLATRFGTGQP----APTAP-RPPGDKKEPAAAP---DSVRKMPQLTASAVVSPQGDESPCG---GTLATAT--AASESRP---LPRVHRARGAPRQQGPGAG-TRDVFQKSRFAP--RGAPHFRFIIAGRQAGRRCRGRLFQTAFP--APYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y6J9-1", "uniprot_id": "TAF6L_HUMAN", "id": "Q9Y6J9-1", "name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "aln": "-------MSEREERRFVEIPRESVRLMAESTGLE-LSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVALQDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADPVRPLCCHYGAVVGLHALG--WKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQ----AAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAG-PEDPSLSVTLADIYRELYAFFGDSLATRFGTGQP----APTAP-RPPGDKKEPAAAP---DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRP---LPRVHRARGAPRQQGPGTG-TRDVFQKSRFAP--RGAPHFRFIIAGRQAGRRCRGRLFQTAFP--APYGPSPASRYVQKLPMIGRTSRPARRWALSDYSLYLPL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FEV1-1", "uniprot_id": "E7FEV1_DANRE", "id": "E7FEV1-1", "name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "aln": "-------MTEREERRFAEVPRESVKLMAESAGVE-LSEELAGLLAEDVCYRLREATQNSSQFMRHAKRRKLSVEDFNRALRWSNTETVCGYGAQDALPFRPLKEGELFYVEDREINLVELALATNIPKGCAETMVRVHVSYLDGKGNLEPQGTVPTAVQSLSEDLLKYYQQITRAILGEDPHLMKVALLDLQSNSKIAALLPYFVYVISGVKSVSHDLDQLNRLLHMVKSLVQNPYLYLGSYVRSLVSSVMYCILEPLAASINPLNDHWTLRDYAALLLSHIFWTHGDLVSGLYHQILLSLQKVLSDPVRPLCSHYGAVVGLHALG--WKAVERVLYPHLPAYWANLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKALSLTLAAEGGSAALSG-SVTGAVGFRENSPGLS-PPPEPLSEPPLGIASHLQAGGAGCPWEEWTPVSLPAMYCELYSFFGDSLAVRFSTDPPLAGAAPAGPSQPLEGRKETATAAPNLESTRKMPQLTASMNISPRQDGSPRTEPQPPSLAATVPGRSLARSSSSSSSVSRSRSSSSRPGRSSSQSRDIFPKARFPLPQAGPPAFSFIIGGRQMGRRCQGRRFQTSFSPTPPLTSLPPRAYAHKLPVIGRVSKPVRRWTSSHYSLHLPL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P53040-1", "uniprot_id": "TAF6_YEAST", "id": "P53040-1", "name": "SAGA complex/transcription factor TFIID complex subunit TAF6", "aln": "-------MSTQQQSYTIWSPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVLNVEPLYGY------------------YDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFDRLIN-EPLPQVP-RLPTFTTHWLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTG-----ASQHLSNVKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPYFIQFIAEQITQNLSDLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLG-GSPKDDSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRVTRTLLKTFLDIN---------RVFGTYYGCLKGVSV-LEGESIRFFLGNLNNWARLVFNESGITLDNIEEH------------LNDDSNPTRTKFTKEETQILVDTVISALLVLKKD---------------------------LPDLYEGKG------------EKVTDEDKEKLLERCGVTIGFHILKRDDAKELISAIFFGE-------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: ::: *:::*: :*** *:* :.::: ** ** **: * ::: :* :*:** *:.:*..:*** ..*.: ** :. *:. . .* . * : : . :* * * ** : ::: . * . : . : : ::*: : .: : ** : . .:.* .: : . . . * .. *: ** *: *: .: . : * ** :.: * ***:: : :* : : .: *. .. *. : . .. .* *:: : ..: ::* .:. .. * *. : :* .: * .: * . : . . : :. :* * : . * : .*.:* . . . .:.: : :..: : : . * : : * . : ..:. ..: : : : * * *: .:. . * ", "identical_positions": 75, "similar_positions": 168, "identity": "11.49%" }, { "cls_id": "homologset.agr.HGNC:17306", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6NZA9-1", "uniprot_id": "TAF9B_MOUSE", "id": "Q6NZA9-1", "name": "Transcription initiation factor TFIID subunit 9B", "aln": "-----------MEPAK------MAPIKNAPRDALVMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKPT-----VDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRYCLTAPNYRLKSLVK-----KGPNQGR---LVPRLS--AVSSRPTTPPVAPPQAVSGPNKAATPVSVTSQRFAVQIP----------PSQSTPAKPAPAATAVQNVLINPSMIGPKNILITTSMVSSQNTATDSNPLKRKHDDDDD-------NDTM--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q62880-1", "uniprot_id": "TAF9B_RAT", "id": "Q62880-1", "name": "Transcription initiation factor TFIID subunit 9B", "aln": "-----------MEPSK------MAPLKNAPRDALVMAQILKDMGITDYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKPT-----VDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRYCLTAPNYRLKSLVK-----KGPNQGR---LVPRLSVGAVSSRPTTPTVAPPQAVSVPNKVATPVSVTSQRFAVQIP----------TSQSTPAKPAPAATSVQNVLINPSMIGSKNILITTNMVSSQSTATDSNPLKRKHDDDDDDDDDDDDNDTM--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9HBM6-1", "uniprot_id": "TAF9B_HUMAN", "id": "Q9HBM6-1", "name": "Transcription initiation factor TFIID subunit 9B", "aln": "-----------MESGK------MAPPKNAPRDALVMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSHAKKPN-----VDADDVRLAIQCRADQSFTSPPPRDFLLDIARQKNQTPLPLIKPYAGPRLPPDRYCLTAPNYRLKSLIK-----KGPNQGR---LVPRLSVGAVSSKPTTPTIATPQTVSVPNKVATPMSVTSQRFTVQIP----------PSQSTPVKPVPATTAVQNVLINPSMIGPKNILITTNMVSSQNTANEANPLKRKHEDDDD-------NDIM--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q27272-1", "uniprot_id": "TAF9_DROME", "id": "Q27272-1", "name": "Transcription initiation factor TFIID subunit 9", "aln": "-----------MSAEKSDKAKISAQIKHVPKDAQVIMSILKELNVQEYEPRVVNQLLEFTFRYVTCILDDAKVYANHARKKT-----IDLDDVRLATEVTLDKSFTGPLERHVLAKVADVRNSMPLPPIKPHCGLRLPPDRYCLTGVNYKLRATNQPKKMTKSAVEGRPLKTVVKPVSSANGPKRPHSVVAKQQVVTIPKPVIKFTTTTTTKTVGSSGGSGGGGGQEVKSESTGAGGDLKMEVDSDAAAVGSIAGASGSGAGSASGGGGGGGSSGVGVAVKREREEEE------FEFVTN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q05027-1", "uniprot_id": "TAF9_YEAST", "id": "Q05027-1", "name": "SAGA complex/transcription factor TFIID complex subunit TAF9", "aln": "MNGGGKNVLNKNSVGSVSEVGPDSTQEETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGSGNSAGSGLGVEDIRLAIAARTQYQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDLEDPKSM-----------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : :..*:*. :: :* . .: :** :* *:::*:.**. :*.** :* .:* . . :. :*:*** : .*. . :..: .:* :*. .** : * ****::****. :: *. . ", "identical_positions": 34, "similar_positions": 54, "identity": "11.33%" }, { "cls_id": "homologset.agr.HGNC:17307", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LW16-1", "uniprot_id": "F1LW16_RAT", "id": "F1LW16-1", "name": "", "aln": "MGYQACPVFLLILDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSANWDTRIAAGQAVEAIVKNVPEWNPVPRTK-----------------QEPT-ECSMEDSSTTDR--LNFDRFDICRLLQHGASLLGSAGAEFEVQDEK----SGEVDP--KERIARQRKLLQKK--LGLNMGEAIGMSTEELFNDEDLDYTPTSAALVNK----------QSTLQAAELIDSEFRAG------MSNRQKNKAKRMAKLFAK---------------QRSRDAVETNEKSNDSTDGEPEEKRRKV-ANVVINQTASDAKVLIDNVPE---SSSFIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLT---------QEQWEVRHGGLLGIKYALAVRQDVINTL--LPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQ-TQKVPSIINTLWDSLLELDD-LTASTNSIMTLLSSMLTYPQVQQCSIQQSLT--------VLVPRVWPFLHHTISSVRRAALETLFTLLSTQ-------DQN----------------SSSWLIPILSDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYVVAAACPWMGAWLCLMMQPSHLPID---LNMLLEVK---------ARTKEKTGGKVRQG--QMQSKEVLQEYIAGADTIMEDPATRDFVVMR--ARMMAAKLLGALCCCICDPG--VNMVNQEIKPAESLGQLLLFHLNSKSALQRISAALVICEWAALQKECKAVTLAVQPRLLDILSEHLY-------YDEIAVPFTRMQNECKQFISSLADA-----------HIEVGNRVNN--NVLTIDQANDLVTTLFNEVTSTFD--LNPQVLQQLDSKRHQVQMTVAETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQYIAKLLQQCTTRTPCPNS-KVIKNLCSSLCVDPYLTPCVTCPVPTQSG--QENSKGSNSEKDGMHHTVTKHRGIITLYRH----QKAAFAITSRRGP-IPKAIKAQIA-DLPAGSSGNILVELDEGQKPYLVQRRGAEFALTTVVKHFGAEMALKLPHLWDAMVGPLKTMIDLNNFDGKSLLERGDAPAQELVNSLQVFETAAASMDSELHP-LLVQHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDNVKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSR-EYLNPLHYTGPPTERIRLQHQV-KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKNTTEKLAVQNSSLHDIQHAPKLSALKQLLLDCGLG-------NGTSSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLD------------KDGKAEKAD----SSTSGKASMKSVLENLSDLWDAEQYDSEYNLETFMRSLE-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9QAE3-1", "uniprot_id": "E9QAE3_MOUSE", "id": "E9QAE3-1", "name": "", "aln": "-------MAVSRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSTNWDTRIAAGQAVEAIVKNVPEWNPVPRTK-----------------QEPT-ESSMEDSSTTDR--LNFDRFDICRLLQHGASLLGSAGAEFEVQDEK----SGEVDP--KERIARQRKLLQKK--LGLNMGEAIGMSTEELFNDEDLDYTPTSAALVNK----------QSTLQAAELIDSEFRAG------MSNRQKNKAKRMAKLFAK---------------QRSRDAVETNEKSNDSTDGEPEEKRRKV-ANVVINQTASDSKVLIDNVPE---SSSLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLT---------QEQWEVRHGGLLGIKYALAVRQDVINTL--LPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQ-TQKVPSIINTLWDSLLELDD-LTASTNSIMTLLSSMLTYPQVQQCSIQQSLT--------VLVPRVWPFLHHTISSVRRAALETLFTLLSTQ-------DEN----------------SSSWLIPILSDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYLVAAACPWMSAWLCLMMQPSHLPID---LNMLLEVK---------ARAKEKTGGKVRQG--QIQNKEVLQEYIAGADTIMEDPATRDFVVMR--ARMMAAKLLGALCCYICDPS--VNMVNQEIKPADSLGQLLLFYLNSKSALQRISVALVICEWAALQKECKAVTLAVQPRLLDILSEHLY-------YDEIAVPFTRMQNECKQFISSLADA-----------HIEVGNRVNN--NVLTIDQANDLVTTIFNEVTSTFD--LNPQVLQQLDSKRHQVQMTVAETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQYIAKLLQQCTTRTPCPNS-KVIKNLCSSLCVDPYLTPCVTCPVPTQSG--QENSKGSNSEKDGMHHTVTKHRGIITLYRH----QKAAFAITSRRGP-IPKAIKAQIA-DLPAGSSGTILVELDEGQKPYLVQRRGAEFALTTIVKHFGAEMAVKLPHLWDAMVGPLKSMIDLNNFDGKSLLERGDVPAQELVNSLQVFEIAAASMDSALHP-LLVQHLPHLYMCLQYPSTAVRHMAARCIGVMSKIATMETMNIFLEKVLPWLGAIDDNVKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSR-EYLNPLHYTGPPTERIRLQHQV-KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKSTTEKLTVQNSSLHDIQHAPKLSALKQLLLDCGLG-------NGSSTESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLD------------KDGKAEKAD----SSTSGKASMKSVLENLSDLWDAEQYDSEYNLETFMRSLE-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14981-1", "uniprot_id": "BTAF1_HUMAN", "id": "O14981-1", "name": "TATA-binding protein-associated factor 172", "aln": "-------MAVSRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSANWDTRIAAGQAVEAIVKNVPEWNPVPRTR-----------------QEPTSESSMEDSPTTER--LNFDRFDICRLLQHGASLLGSAGAEFEVQDEK----SGEVDP--KERIARQRKLLQKK--LGLNMGEAIGMSTEELFNDEDLDYTPTSASFVNK----------QPTLQAAELIDSEFRAG------MSNRQKNKAKRMAKLFAK---------------QRSRDAVETNEKSNDSTDGEPEEKRRKI-ANVVINQSANDSKVLIDNIPD---SSSLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLT---------QEQWEVRHGGLLGIKYALAVRQDVINTL--LPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQ-TQKVPFIINTLWDALLELDD-LTASTNSIMTLLSSLLTYPQVQQCSIQQSLT--------VLVPRVWPFLHHTISSVRRAALETLFTLLSTQ-------DQN----------------SSSWLIPILPDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYVVAAACPWMGAWLCLMMQPSHLPID---LNMLLEVK---------ARAKEKTGGKVRQG--QSQNKEVLQEYIAGADTIMEDPATRDFVVMR--ARMMAAKLLGALCCCICDPG--VNVVTQEIKPAESLGQLLLFHLNSKSALQRISVALVICEWAALQKECKAVTLAVQPRLLDILSEHLY-------YDEIAVPFTRMQNECKQLISSLADV-----------HIEVGNRVNN--NVLTIDQASDLVTTVFNEATSSFD--LNPQVLQQLDSKRQQVQMTVTETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQCIAKLLQQCTTRTPCPNS-KIIKNLCSSLCVDPYLTPCVTCPVPTQSG--QENSKGSTSEKDGMHHTVTKHRGIITLYRH----QKAAFAITSRRGP-TPKAVKAQIA-DLPAGSSGNILVELDEAQKPYLVQRRGAEFALTTIVKHFGGEMAVKLPHLWDAMVGPLRNTIDINNFDGKSLLDKGDSPAQELVNSLQVFETAAASMDSELHP-LLVQHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDSVKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSAELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCHRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSR-EYLNPLHYTGPPTERIRLQHQV-KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSATLSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKTTAEKLAVQNSSLHDIQHAPKLSALKQLLLDCGLG-------NGSTSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLD------------KDGKAEKAD----TSTSGKASMKSILENLSDLWDQEQYDSEYSLENFMHSLK-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BGW0-1", "uniprot_id": "A0A8M2BGW0_DANRE", "id": "A0A8M2BGW0-1", "name": "", "aln": "-------MAVSRLERLFILLDTGTTPVTRKAAAQQLGDVVKLHPHELNNLLSKVLTYLRSPNWDTRIAAGQAVEAIVKNIPEWNPSPKPK-----------------DEVCAEDLSPEDVSTDR--LSFYRFDISRLLKHGASLLGSAGAEFELQDDK----SGETDP--KERLARQRKQLQKK--LGLDMGAAIGMDTEELFNDEDLEDACASSTNRTQPGKSLGCHFSRNHLPAAELIDSEFRPG------MSNRQKNKAKRMAKLVAK---------------QRSRD-VDSNEKSNDSFEGEPEEKRRKT-TNVVIEQPANDSKVLIDNVPD---NSSLFEETQEWPLESFCDELCNDLFNPSWEIRHGAGTGLREVLKCHGAGGGKTVGSTAEQMERQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVALRHMENSGVAMTVDILLKLLT---------EDQWEVRHGGLLGIKYALAVRQDLIAEL--LPRVLPAITEGLRDLDDDVRAVAAAALIPVVDGLVQLQ-PAKVPFIVDTLWNALLELDD-LTASTNSIMTLLSSLLTYPQVRQCSTQQSLT--------VLVPRVWPFLRHTIASVRRAALDTLFTLLSKA-------DQS----------------CAVWLNPIMQDMLRHIFQSCILESNQEILELIQKVWRELLRQAPQQYVVAASCPWMGAWLCLMMQAPHIPID---PNMLLEVK---------ARFKEKAAGKARQG--SVPVKETVQEYIGGAETVTEEPATRDYVVTR--ARLMAAKLLGALCSCICDPR--LNSSSLELRPAESLAQLLLFHLNSKSALQRIAVSMVICEWAGLQKECELLSSVVQPRLLVILSEQLY-------YDEIAIPFTRMQNECKQLIALLADA-----------HIDVRERINS--TVFTIDQANELVTTIFSESTSTLN--LKSRQFQPLDSKRIQAQSTVCETSAEWQQLQLRVHTFTACAVVGLGMLPDKLNPVVRPLMEAARREENSLVQGCAASNIAHLLQLCAARSPCPNA-KIVKNLCSSVCVDPMLTPSAACPVPPASTPIQESSKASVAEKDAMHHMVNKTKGIITLYRH----QKAAFAITSKRGP-TPKTPKSNTNNDLPVG--GSISTETDESKKPCLIQRRGAEFCLMTVARHFSKELTKTLPYLWESMTGPLRNALDAQEFDSSQLLKQGDSVAQDLVNSLQVLEVTAGAMSQELIP-LLMEQLPLLCTCLQHPYTAVRHMAARCVGVLSKIATMETMNVFLEQVLPWLGAIDDNTKQEGAIEALACVMEQLDVDIVPYIVLLVVPVLGRMSDPCDSVRFMATQCFATLIRLLPLEAGIPDPPSMSEDLIRQKARERHFLEQLLDGRKLENYKIPVPIKAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFLRAQEYTRTKAPDSCPLPSIVVCPPTLTGHWVDEVGKFCSK-EFLNPLHYTGPPTERARLQHQV-KKHNLIVASYDVVRNDVEFFRDIKFNYCILDEGHVIKNGKTKLSKAIKQLTANYRLILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDAKSSSREQEAGVLAMEALHRQVLPFLLRRMKDDVLQDLPPKIIQDYYCNLSPLQVQLYEDFAKSRAKVNVDDVISTASTQEDEEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEYKHITEQLSTQHSSLRDIQHAPKLSALKQLLLDCGLG-------SAGASDSGTEAVVAQHRVLIFCQLKSMLDIVEQDLLKPQLPGVTYLRLDGSVQAGLRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMTIANTVISQENASLQSMGTEQLLNLFTLD------------KDDKAEKCDG--SSSSSGKSSMKSVLDGLGDLWDQQQYENEYDLGTFMHSLK-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VF02-1", "uniprot_id": "Q9VF02_DROME", "id": "Q9VF02-1", "name": "", "aln": "--------MTSRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEAILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHKGARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDK--LGLTTAAKLGVNLTDMITDEDVALNRSGSTYNVN----------AEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNTSGCSVTAVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKK-LKSTDRQEIFYS--LNAAVPD---ATGTWVDAVSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQMDEAHSRWLEDAALRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLIQH--------KNEWDVRHGGLLGLKYVFVVREELLPIY--LPQSISNILIGLLDAVDDVGAVAAATLIPVSSWLPKLLNPAQVSSIVKMLWDLLLDQDE-LTSACNSFMGLLAAILCLPNAARWVEMEPMA--------ILVPRLWPFLSHSTSSVRRSTLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWELLQQALRHIYQRILVEPQADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFD---AGVLIRAGGDVSTPGSTSRKRTPRIGDELGGNILAQSNASLKLYLGGSEATPLD--VRDANFMR--ARISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVRPGPPNLQEKLHQCVSEYVY-------YDEVAISLTRLLQEAQDFIATLKQN-----------KIPINDFNNA--KILTLDQIEAVATTLS-ENLRSYP--LKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNS-KILNNLCTLLRSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALHP-QMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDG--KTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHR-------QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTEN--LSAKTHIFQALRYLQNVCNHPKLVLR-QSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIG-------VQTES-------VSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGG------------KDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDLGNFVQALKK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32333-1", "uniprot_id": "BTAF1_YEAST", "id": "P32333-1", "name": "TATA-binding protein-associated factor MOT1", "aln": "-----MTSRVSRLDRQVILIETGSTQVVRNMAADQMGDLAKQHPEDILSLLSRVYPFLLVKKWETRVTAARAVGGIVAHAPSWDPN---------------------ESDLVGGTNEGSPLDNAQVKLEHEMKIKLEEATQNNQLNLLQEDHHLSSLS----DWKLNEILKSGKVLLASSMNDYNVLGKADDNIRKQAKTDDIKQETSMLNASDKANENK---------SNANKKSARMLAMARRKK-------KMSAKNTPKHPVDITES---------------SVSKTLLNGKNMTNSAASLATSPTSNQLNPKLEITEQADESKLMIESTVRPLLEQHEIVAGLVWQFQGIYELLLDNLMSENWEIRHGAALGLRELVKKHAYGVSRVKGNTREENNLRNSRSLEDLASRLLTVFALDRFGDYVYDTVVAPVRESVAQTLAALLIHLDSTLSIKIFNCLEQLVLQDPLQTGLPNKIWEATHGGLLGIRYFVSIKTNFLFAHGLLENVVRIVLYGLNQSDDDVQSVAASILTPITSEFVKLN-NSTIEILVTTIWSLLARLDDDISSSVGSIMDLLAKLCDHQEVLDILKNKALEHPSEWSFKSLVPKLYPFLRHSISSVRRAVLNLLIAFLSIK-------DDS----------------TKNWLN---GKVFRLVFQNILLEQNPELLQLSFDVYVALLEHYKVKHTEKTLDHVFSKHLQPILHLLNTPVGEKGKNYAMESQYILK-----PSQHYQLHPEKKRSISETTTDSDIPIPKNNEHINIDAPMIAGDITLLGLDVILNTRIMGAKAFALTLSM--FQDSTLQSFFTNVLVRCLELPFSTPRMLAGIIVSQFCSSWLQKHPEGEKLPSFVSEIFSPVMNKQLLNRDEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLPNVAIVVQGETEAGPHAFGVETAEKVYGEYYDKMFKSMNNSYKLLAKKPLEDSKHRVLMAINSAKESAKLRTGSILANYASSILLFDGLPLKLNPIIRSLMDSVKEERNEKLQTMAGESVVHLIQQLLENNKVNVSGKIVKNLCGFLCVDTSEVPDFSVNAEYKEK---------------ILTLIKE-----------------------------------------SNSIAAQDDINLAKMSEEAQLKRKGGLITLKILFEVLGPSILQKLPQLRSILFDSLSDHENEEAS------KVDNEQGQKIVDSFGVLRALFPFMSDSLRSSEVFTRFPVLLTFLRSNLSVFRYSAARTFADLAKISSVEVMAYTIREILPLMNSAGSLSDRQGSTELIYHLSLSMETDVLPYVIFLIVPLLGRMSDSNEDVRNLATTTFASIIKLVPLEAGIADPKGLPEELVASRERERDFIQQMMDPSKAKPFKLPIAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRKEDYEKTRSVESRALPSLIICPPSLTGHWENEFDQYAPF---LKVVVYAGGPTVRLTLRPQL-SDADIIVTSYDVARNDLAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHRLILTGTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALEALHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQKQLYMDFTKKQKNVVEKDIENSEIAD---------GKQHIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQTGLDLHDIINAPKLSALRTLLFECGIGEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMVENDLFKKYMPSVTYMRLDGSIDPRDRQKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVVNQQNSGLASMDTHQLLDLFDPDNVTSQDNEEKNNGDSQAAKGMEDIANETGLTGKAKEALGELKELWDPSQYEEEYNLDTFIKTLR-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *:* .**::**:* ..*: **.*:*:: * :*.:: **.:: :* .*:**::*.::* .*: : * *:* :. . . .:.: :. :..:.. . . : : . ::. ** : :.:* :. : : .:: . * .*: . . . *. :. :*.: . .: : : : : * ::.: . * :*: .**:****. .***::: *. . .: .* *: :.. *** . *** *:.******:* * *******: **.*.. : .:: : .: * :*: :. *:. ******::* . :: :.: * . : : ** : *** :***: * *: . : * : :: :*. * *: :::: .*:* **: : :. :.: ***:::*** *: :****:.*. *::: * *:. * . :* ::* ::* . :: * .*: *: : : .. : :: . ... . :. . : . . . : . . . : :: :** . : . . :: : * :.: : * . . . * . . . :. : :.: : : *:. .:. : :.:.::: : : * : : : :: . : : : : . *:. : : .:. . . : * :: : ** ****:::.**:: :.*. :* :.. :.:*:: .. : *:::*** : *. .* . : : . : ::* *. : : . :. .: .:. : : . : . . :.:*.*: ::. : * . :. :* * : ...*: *** .. :::* : :.* :..:** :. . .::*: * : : :: ::**:::*:**:** *** :.** ::* **.:::*:**:. . * : ::*.*:: ::: . :*:*:.*.. ** *** *:*** *****:****************:***:*.*: * : : ***:::***:***** *. :: *. : * * *. * *: :: . :::*:***..*:*: .: .:***:*****:***.::* :**:*.:.**:*:**:**************************: * *:.:** :**::::*::********::***:*****:***:*:***.****** ** * *. ** :** **::.: : .. .: . .. *:****:*::::**** *** : : . * .* ** ::.**.**: **::**:* ::*** ******* ***:**:**:: :*.***:*****: . *:.:* .**.***** ***** **************:*********.**************:******:**:.:************: *.**:. :*:.* :*.* *:::** . * * . :. . : : * :**. **:.**.* .*:::*. ", "identical_positions": 488, "similar_positions": 557, "identity": "23.95%" }, { "cls_id": "homologset.agr.HGNC:17310", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9VJP1-1", "uniprot_id": "Q9VJP1_DROME", "id": "Q9VJP1-1", "name": "", "aln": "-MEEYSREPCPHRIVDDCGGAFIMGCVGGGLFQGLKGFRNAPQGLGRRVAGSVAAIKTKSPVIGGSFAAWGAVFSIVDCSLVHFRQKEDPWNSIVSGAVTGGILASRN---------------------------GAAAMAGSAIIGGVLLSMIEGLGIFFTRFAAEQFR-----------------NREPH--------IMPDANEGYGDFNSS-GFGFPGAQQATATS---------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VRF6-1", "uniprot_id": "Q9VRF6_DROME", "id": "Q9VRF6-1", "name": "", "aln": "-MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLKRRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSLVHLRKKEDPWNSIMSGAIAGGILSSRN---------------------------GVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQFR-----------------NSDPQNDLGRAGAFASGSGMGSGDINSSPGFEFPVVQQANATS---------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9Z0V7-1", "uniprot_id": "TI17B_MOUSE", "id": "Q9Z0V7-1", "name": "Mitochondrial import inner membrane translocase subunit Tim17-B", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRFRGSVNAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSISSGALTGAVLAARS---------------------------GPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFR-----------------NAPPF---------LEDPSQLT-PKEGSPAPGYPNYQQYH------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8J8XD91-1", "uniprot_id": "A0A8J8XD91_RAT", "id": "A0A8J8XD91-1", "name": "", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAVKGFRNAPVGIRHRFRGSINAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSECFQPLTPVLALFCLPFLSCVSFCLPGGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFR-----------------NAPPF---------LEDPNQLT-PKEGAPAPGYPNYQQYH------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O60830-1", "uniprot_id": "TI17B_HUMAN", "id": "O60830-1", "name": "Mitochondrial import inner membrane translocase subunit Tim17-B", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARS---------------------------GPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFR-----------------NAPPF---------LEDPSQLP-PKDGTPAPGYPSYQQYH------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A8WHN3-1", "uniprot_id": "A8WHN3_DANRE", "id": "A8WHN3-1", "name": "", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGAIGGGVFQTVKGFRNAPVGVRHRLRGSANAVRVRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGAMTGAILAARS---------------------------GPLAMVGSAMMGGILLALIEGFGILLTRYTAQQFQ-----------------NSSPI---------VEDPKQLP-PKE--EARGYGQYQ---------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q7PLT4-1", "uniprot_id": "Q7PLT4_DROME", "id": "Q7PLT4-1", "name": "", "aln": "-MEEYAREPCPYRIVDDCGGAFAMGCIGGGVFQAIKGFRNAPSGLNRRLVGSIIAIKTRSPVIAGNFAVWGGMFSTIDCTLVHFRKKEDPWNSIISGAATGGILAARN---------------------------GVPAMAGSAIIGGVLLALIEGVGILFTRISADQFK-----------------NPIPP---------AEDPVALGDPGRNFSFESASNRTQYQ------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39515-1", "uniprot_id": "TIM17_YEAST", "id": "P39515-1", "name": "Mitochondrial import inner membrane translocase subunit TIM17", "aln": "MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSP--LGERGSGAMSAIKARAPVLGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGALAVRG---------------------------GWRHTRNSSITCACLLGVIEGVGLMFQRYAAWQAK-----------------PMAPP---------------LPEAPSSQPLQA--------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VNA0-1", "uniprot_id": "TI17A_DROME", "id": "Q9VNA0-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 1", "aln": "-MAEYGREPCPFRIVEDCGGAFAMGALGGGAFQAIKGFRNAPSGLGYRLSGGLAAVRARSGLVGGNFAVWGATFSAIDCSLVYFRKKEDPWNAIISGATTGGILAART---------------------------GLTSMLSSALVGGALLALIEGVGIVVSHYSADSYR-----------------QVSPVER-----QQRYKQELLRQQKGVSPLAATYGEIDSSAL----------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VN97-1", "uniprot_id": "TI17D_DROME", "id": "Q9VN97-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 4", "aln": "--MEYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSWNAIVSGAATGGILAARN---------------------------GIRAMANSAFVGCLVLAMLEGAGAAVATIYASDGG----VKAEESLITVDQQMQRPQWETSVADSNLTGAELERVLDECRAYRAHNKMQQPMRSDAVEGKELGQLMKPMHSLVDLVKLAEIV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VGA2-1", "uniprot_id": "TI17C_DROME", "id": "Q9VGA2-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 3", "aln": "--MEYNRQPCPIRIVEDCGCAFMMGTIGGSLFEFLKGFRNAPTGLQRRLYGGIDLVKMRTPSIAGSFAVWGATFSTVDCALVHYRQREDAWNSILSGAATGGILAARN---------------------------GIRAMANSALVGCLVLAMIEGAGAAVATINAADKGAGIVIKPQRAQWEAILETIDPKRASSTQDFAL--AEFERVLDKCRASREPNLLQDIP----VKSHERDSKQKPFYSLLDLVKLSQMF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: *:*** *::* * ** ** .** :. :*****:* : *. :: :: :.*.*. ** ** .** : * :**.**:* :* :*. *: * * .*:: :*.::** * . * . * ", "identical_positions": 46, "similar_positions": 38, "identity": "17.9%" }, { "cls_id": "homologset.agr.HGNC:17311", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8C5D8-1", "uniprot_id": "PIAS2_MOUSE", "id": "Q8C5D8-1", "name": "E3 SUMO-protein ligase PIAS2", "aln": "--------------------------------------MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTL---EGLCDLSTIKSSVFS---LDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQ-EKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILN---DCSDVDEIKFQEDGSWCPMRP----------------------------------------------------------KKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEED-PPAKRKCIFMSET----------QSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSV---------------------------------PFHHTPVSSMSSDLPG---LDFLSLIPVDP--QYCPPMFLDSLTSPLTASSTSVTTTSP-------------------------------------------------------------------------------HESSTHVSSSSSRSETGVITSSGRNIPDIISLD---------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75928-1", "uniprot_id": "PIAS2_HUMAN", "id": "O75928-1", "name": "E3 SUMO-protein ligase PIAS2", "aln": "--------------------------------------MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTL---EGLSDLSTIKSSVFS---LDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQ-EKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILN---DCSDVDEIKFQEDGSWCPMRP----------------------------------------------------------KKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDEEED-PPAKRKCIFMSET----------QSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSV---------------------------------PFHHTPISSMSSDLPG---LDFLSLIPVDP--QYCPPMFLDSLTSPLTASSTSVTTTSS-------------------------------------------------------------------------------HESSTHVSSSSSRSETGVITSSGSNIPDIISLD---------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6AZ28-1", "uniprot_id": "PIAS2_RAT", "id": "Q6AZ28-1", "name": "E3 SUMO-protein ligase PIAS2", "aln": "--------------------------------------MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCTPAVQIKIRELYRRRYPRTL---EGLSDLSTIKSSVFS---LDGSSSPVEPDLAVAGIHSLPSTSIAPHSPSSPVASVLLQDTKPTFEMQQPSPPIPPVHPDVQLKTLPFYDVLDVLIKPTSLVQSSIQRFQ-EKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILN---DCSDVDEIKFQEDGSWCPMRP----------------------------------------------------------KKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEED-PPAKRKCIFMSET----------QSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSV---------------------------------PFHHTPVSSMSSDLPG---EQRRNDINNEV--QLG-------------TSSDTVQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A8M2BCP8-1", "uniprot_id": "A0A8M2BCP8_DANRE", "id": "A0A8M2BCP8-1", "name": "", "aln": "--------------------------------------MADIEELRNMVSSFRVSELQVLLGFAGRNKSGRKHELLLRALHLLRSGCSSAVQIKIKELYRRRYPRTF---EGLQDLAALKSSIKSFIHLDSGATAVSSDLTLP-----TDHSDVLQQRRESCDSPVFHESKPMMNMQQPTTLMAPVHPDVQMKSLPFYDVLDVLIKPSSLGAHAVQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQEDNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPNQIVVTWAPEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEILN---DCTDVDEIQFQEDGTWCPMRP----------------------------------------------------------KKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVIDLTLESSSDDEEDDPPLKKRCIYMSKA----------EEMHSKGVLTYQPSTVRVPNVQSLDTSYLTSSIADYSV---------------------------------PFHHSSLSTIPTDMQS---LDLFSLIQGDPQQHFRGPIFLDSLSSSLQSATTSASLVSSS------------------------------------------------------------------------------AQYETATHSSSSSHETGVITGGSSGLSDIISLD---------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z7P5-1", "uniprot_id": "A1Z7P5_DROME", "id": "A1Z7P5-1", "name": "", "aln": "MRKTRSQTARTQAENAATSSSPGHQSTSSAPIAVNPFDSTKYKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRT-NLELLAPKVQEVYAQSVQEQN---ATLQYIDPTR--MYSHIQLPPTVQPNPVGLVGSG-----------QGVQVPGGQMNVVGGAPFLHTHSINSQLP-IHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQ-EVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGL----------------------------------------------------------RSETQILDTP-------SKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSD----------SDDDMPLAKRRPPAKQAVASSTSNGSGGGQRAYTPAQQ---------------------------------PQQSESPEQQASRQSP---EKQTVSEQQLQQQQHEQPATAAVHASLLESLAAAVADQKHF------------------------------------------------------------------------------QLLDLAAVAAAAAATASSGQSQNAGP----------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12216-1", "uniprot_id": "SIZ2_YEAST", "id": "Q12216-1", "name": "E3 SUMO-protein ligase SIZ2", "aln": "-----MASVMSNNNNNNNNNNASYMFTNPLSNTGG-GLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTG------------------------AFKHPVASGQLPVTALQSTALPPYSQQQALAYS---------FTSPFYKPIVQIPDANKKLKQSAGRGCTKMKFKVSKSNHDLLKS-------NKSYKLYLFSGFSIPFIYETVGHEAIDFPYPCELVFNG-----TKLEDNVKGLKKQNGTGNPANLTPYLKVPTEM-NHLDLHYL-NIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQN--CNEDVEQVEISVDGSWKPIHN--------------------------------------------------SSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKS-FPTHVNPR----------NDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNY----------------------QDAFQMRSFLNQGATTNINDTPTNNSS--INSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQ--------RNPYGPNYNTTAQDRNLLG---------------------------------------------------IEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSG--------HGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFN---TSAQDNSEVVDLTSD", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q04195-1", "uniprot_id": "SIZ1_YEAST", "id": "Q04195-1", "name": "E3 SUMO-protein ligase SIZ1", "aln": "---------MINLEDYWEDETP-----GPDREPTN-ELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVTGGRGMCSAKFKLSKADYNLLSNP------NSKHRLYLFSGMINPLGSR--GNEPIQFPFPNELRCNN-----VQIKDNIRGFKSKPGTAKPADLTPHLKPYTQQ-NNVELIYA-FTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQN--CQKNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: :. ::* **: : . :*:* * :*:. : : * : . * . . .**. : . * . * .: : : . : .. . : :* : *. : . . .* ::*. :: . * : : : : * : ::*. ::. ** :: : : : :*..* : : : ** :** **:. :: *.:: *.*:***** :*: : : *** **:*: :.* :. . ::: : :::: **.* . .. . . ... . .. .:: . . .. .. : . . . : ", "identical_positions": 49, "similar_positions": 126, "identity": "5.24%" }, { "cls_id": "homologset.agr.HGNC:17312", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35093-1", "uniprot_id": "TIM23_RAT", "id": "O35093-1", "name": "Mitochondrial import inner membrane translocase subunit Tim23", "aln": "---MEGGGGSSNKSTGGLAGFFGAGGAGYSNADLAGVP------LTG-------MNPLSPYLNVDP--RYLVQDTDEFILPTGAN---KTRGRFELAFFTIGGCCMTGAAFGALNGLRLGLKETQSMPWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDFNTVAAGTMTGMLYKCTGG------LRGIARGGLAGLTLTSVYALYN--------------------------------NWEHMKGSLLQQSL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WTQ8-1", "uniprot_id": "TIM23_MOUSE", "id": "Q9WTQ8-1", "name": "Mitochondrial import inner membrane translocase subunit Tim23", "aln": "---MEGGGRSSNKSTSGLAGFFGAGGAGYSNADLAGVP------LTG-------MNPLSPYLNVDP--RYLVQDTDEFILPTGAN---KTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGG------LRGIARGGLAGLTLTSLYALYN--------------------------------NWVHMKGSLLQQSL-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14925-1", "uniprot_id": "TIM23_HUMAN", "id": "O14925-1", "name": "Mitochondrial import inner membrane translocase subunit Tim23", "aln": "---MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVP------LTG-------MNPLSPYLNVDP--RYLVQDTDEFILPTGAN---KTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGG------LRGIARGGLTGLTLTSLYALYN--------------------------------NWEHMKGSLLQQSL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7T2P6-1", "uniprot_id": "TIM23_DANRE", "id": "Q7T2P6-1", "name": "Mitochondrial import inner membrane translocase subunit Tim23", "aln": "---MDNSTPPPGGFKGGLGSIFGGGTPEYSNTELSGVP------LTG-------MSPLSPYLNVDP--RYLIQDTDEFILPTGAN---KTRGRFELAFFTIGGCCITGAAFGTLNGLRMGLSETRDMPWSKPRNVQILNMVTRQGASWANTLGSVALLYSVFGVAIEKARGAEDDLNTVAAGTLTGMVFKSTGG------LKGVARGGLIGLAMSGLYALYN--------------------------------NWDHLKGKSPSHY--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AC58H3S6-1", "uniprot_id": "A0AC58H3S6_DANRE", "id": "A0AC58H3S6-1", "name": "", "aln": "---MDKDS-SGSRNPAGFG-LFGSAGPQYSKAELAGVP------LTG-------MSPISPYLNVDP--RYLIQDTDEFILPTGAN---KTRGRFELAFFTIGGCCITGALCGAVNGLRMGLSETRNMAWSKPQNVQILNMVTRQGATWANTLGSVALLYSAFGVIIEKARGAEDDLNTIAAGTMTGVLYKSPAEDFIEQCFSTTFNQGFSSTFHPALHVFHVSFTKHTQIISSAAETERFVKGVTDKGDIQSMQCWWALRNVVEKHCHR", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P32897-1", "uniprot_id": "TIM23_YEAST", "id": "P32897-1", "name": "Mitochondrial import inner membrane translocase subunit TIM23", "aln": "MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKG---------LKPMGYSSAMVAAACAVWC-----------------------------------SVKKRLLEK---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . . .... * : *. ::* : * .:* .** : ::: *:: :** : : *. : * * ..*: **.: . .* : :** :*::*. .*. * :** *. :. *: ** .* .::.**::** ::*.. * . .. .. :: .: ", "identical_positions": 36, "similar_positions": 67, "identity": "13.38%" }, { "cls_id": "homologset.agr.HGNC:17313", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R0U1-1", "uniprot_id": "IP6K2_RAT", "id": "Q9R0U1-1", "name": "Inositol hexakisphosphate kinase 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPAFRTMDVEPRTKG----------------------------------------------ILLEPFVHQVGGHSCVLRFNETTLCKPLVPR-----------EHQFYETLPAEMRRFTPQYK-----------------------GVVSVRFEEDEDRNLCLIAYP--------------------LKGDHGPVDIVDNSDCEPKSK------LLRWT-NKKHHVL-------------------------------------------------------------------------------------ETEKSPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVE----------KKGTVSSQLKHYN----------------------------------------------PWSMKCHQQQLQRMKEN----------------------------------------------AKHRNQYKFILLENLTCRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSV-QGFKEALFQFFHNGRYLR--RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKE--------------WPEVTLDS---------------DAEDLEDLSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SADESAGAYAYKPLG-------------------------------------------------------------------------------------------------------------------------------------------------------------ASSVDVRMIDFAHTTCRLYG-------EDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80V72-1", "uniprot_id": "IP6K2_MOUSE", "id": "Q80V72-1", "name": "Inositol hexakisphosphate kinase 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPAFRTMDVEPRTKG----------------------------------------------ILLEPFVHQVGGHSCVLRFNETTLCKPLVPR-----------EHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYP--------------------LKGDHGTVDIVDNSDCEPKSK------LLRWT-NKKHHAL-------------------------------------------------------------------------------------ETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVE----------KKGNVSSQLKHYN----------------------------------------------PWSMKCHQQQLQRMKEN----------------------------------------------AKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSV-QGFKEALFQFFHNGRYLR--RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKE--------------WPEVTLDS---------------DAEDLEDLSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SADESAGAYAYKPIG-------------------------------------------------------------------------------------------------------------------------------------------------------------ASSVDVRMIDFAHTTCRLYG-------EDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UHH9-1", "uniprot_id": "IP6K2_HUMAN", "id": "Q9UHH9-1", "name": "Inositol hexakisphosphate kinase 2", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPAFRAMDVEPRAKG----------------------------------------------VLLEPFVHQVGGHSCVLRFNETTLCKPLVPR-----------EHQFYETLPAEMRKFTPQYK-----------------------GVVSVRFEEDEDRNLCLIAYP--------------------LKGDHGIVDIVDNSDCEPKSK------LLRWTTNKKHHVL-------------------------------------------------------------------------------------ETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVE----------KKGNISSQLKHYN----------------------------------------------PWSMKCHQQQLQRMKEN----------------------------------------------AKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV-QGFKEALFQFFHNGRYLR--RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKE--------------RPEVVLDS---------------DAEDLEDLSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SADESAGAYAYKPIG-------------------------------------------------------------------------------------------------------------------------------------------------------------ASSVDVRMIDFAHTTCRLYG-------EDTVVHEGQDAGYIFGLQSLIDIVTEISEESGE-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9W2E9-1", "uniprot_id": "Q9W2E9_DROME", "id": "Q9W2E9-1", "name": "Kinase", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVYFLGDWGMGDSDLSSYQQH----------------------------------------------VPNIQQPRRIHGHDLLLQQQQQQLPQQQQQQQQQQQQ----QQQEFVAQISSSLSQVQAQLQFASGSSFLQQGSSPSPSQQQHG-PVSSSSLVTANLQQLSVSSSN--------------------ASSSSSNNNSASGCNTPTKPQKQKPLLLPEAAASTATAVG-------------------------------------------------------------------------------------KSSKNPQLSKDLLDNEDEVALHPLSNQVGGHTRLLLLNQSTV----------IKPLNLRELDFYQNIPQDILKFVPKYKGVMQATTMGGAKLDKRYSPSFRDDAAAVPVRKMSASKRKRDEVLRMKVHKNGQAAEVIKS--------------------------------ISQLDNTNKQYFLMLENITSQFRNPCILDLKMGTRQHGDDASAEKRSKQMAKCAASTSGSLGVRLCGMQTYLADLEQYAKRDKYWGRELNE-GGFKTALHDFFHNGYRLR--IRVIRKILQRLLQLRRVIEKQSSYRFYSCSLLIVYEGFEENPMAPPPSMSQDEWPEAPRSATVPGTVFDYHPENSIDEDDLEDDDEAGNEAGDELEAHDTDDDLHLVAADSGNASATNSSTGGDACNYDADASNDSNSLLNLATRRHLHKRGFAEAAARGVKQTASHNTTTDEEEEDEHPAMPPPRTCGVMAAKAAAAAAGLAGKGQGAFIPISEETVFLDPEPALPSVTTSSPHSGDSWMNYSSNSSDDFSGLSEQIKAVASGRQTCNNSSDDASSDYESSIIGPTEAMFKRYKSQQSFDAATAADSASSPPLTAGNSSVSNGGTTVRSLVSPASSSASSLKSVKGAVKRLRCNDDDQQSASLGESDLREAKKSTITSTPVSAVSSPAKAAPQLRSCESISNQQSLLSGLLLDNNNEQRRNALLQQSSKSLDMSAPPTDDNQCFVDVRLIDFAHTAFVPRNGTMLPTPAAAPVHHGPDGGFLTGLDSLNRLLNEIVAEERA-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12494-1", "uniprot_id": "KCS1_YEAST", "id": "Q12494-1", "name": "Inositol hexakisphosphate kinase 1", "aln": "MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKD--YYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDAN-------------KSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKSPNIEDKGFLRGVKSLRFYLLLIWN------------------------------------------------------------------------------------------------------------------------YLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFD----KEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .: ::. : : .:: ** ::: .: : : : .::: :. : . : : . . : ::.: : . . : . . .. * . . . . ..*. ... : : . . * * ::. . :: : *. . .: *::**::* . . ** *********:* **. * .* ** :** :***:**::.: . :** **.:. * .* *:::* :. . : ::::* * : . ..**:*..***::*:* .: . :* : : *.: : . . *:* . ::.. :. . :. . ", "identical_positions": 58, "similar_positions": 135, "identity": "4.25%" }, { "cls_id": "homologset.agr.HGNC:17315", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35092-1", "uniprot_id": "TI17A_RAT", "id": "O35092-1", "name": "Mitochondrial import inner membrane translocase subunit Tim17-A", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSTIDCGMVQIRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFP-----NGPQF------------AEDHSQL--PSSQLPSSPFGDYRQYQ---------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0V8-1", "uniprot_id": "TI17A_MOUSE", "id": "Q9Z0V8-1", "name": "Mitochondrial import inner membrane translocase subunit Tim17-A", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAFKGFRNSPVGINHRLRGSLTAIKTRAPQLGGSFAVWGGLFSTIDCSMVQIRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFP-----NGPQF------------TEDHSQL--PSSQLPSSPFGDYRQYQ---------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99595-1", "uniprot_id": "TI17A_HUMAN", "id": "Q99595-1", "name": "Mitochondrial import inner membrane translocase subunit Tim17-A", "aln": "-MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFP-----NGPQF------------AEDPSQL--PSTQLPSSPFGDYRQYQ---------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7PLT4-1", "uniprot_id": "Q7PLT4_DROME", "id": "Q7PLT4-1", "name": "", "aln": "-MEEYAREPCPYRIVDDCGGAFAMGCIGGGVFQAIKGFRNAPSGLNRRLVGSIIAIKTRSPVIAGNFAVWGGMFSTIDCTLVHFRKKEDPWNSIISGAATGGILAARNGVPAMAGSAIIGGVLLALIEGVGILFTRISADQFK-----NPIPP------------AEDPVALGDPGRNFSFESASNRTQYQ---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJP1-1", "uniprot_id": "Q9VJP1_DROME", "id": "Q9VJP1-1", "name": "", "aln": "-MEEYSREPCPHRIVDDCGGAFIMGCVGGGLFQGLKGFRNAPQGLGRRVAGSVAAIKTKSPVIGGSFAAWGAVFSIVDCSLVHFRQKEDPWNSIVSGAVTGGILASRNGAAAMAGSAIIGGVLLSMIEGLGIFFTRFAAEQFR-----NREPH--------IMPDANEGYGDFNSS-GFGFPGAQQATATS---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VRF6-1", "uniprot_id": "Q9VRF6_DROME", "id": "Q9VRF6-1", "name": "", "aln": "-MEEYSREPCPFRIVDDCGGAFTMGCFGGGLFQGLKGFRNAPQGLKRRFAGGLAAVKSRSPTIGGNFAAWGCVFSIVDCSLVHLRKKEDPWNSIMSGAIAGGILSSRNGVAAMFGSAIIGGVLLSMIEGVGILFTRISAEQFR-----NSDPQNDLGRAGAFASGSGMGSGDINSSPGFEFPVVQQANATS---------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P39515-1", "uniprot_id": "TIM17_YEAST", "id": "P39515-1", "name": "Mitochondrial import inner membrane translocase subunit TIM17", "aln": "MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSP--LGERGSGAMSAIKARAPVLGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGALAVRGGWRHTRNSSITCACLLGVIEGVGLMFQRYAAWQAK-----PMAPP---------------------LPEAPSSQPLQA--------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VNA0-1", "uniprot_id": "TI17A_DROME", "id": "Q9VNA0-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 1", "aln": "-MAEYGREPCPFRIVEDCGGAFAMGALGGGAFQAIKGFRNAPSGLGYRLSGGLAAVRARSGLVGGNFAVWGATFSAIDCSLVYFRKKEDPWNAIISGATTGGILAARTGLTSMLSSALVGGALLALIEGVGIVVSHYSADSYR-----QVSPVE-----------RQQRYKQELLRQQKGVSPLAATYGEIDSSAL----------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VN97-1", "uniprot_id": "TI17D_DROME", "id": "Q9VN97-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 4", "aln": "--MEYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAGAAVATIYASDGG----VKAEESLITVDQQMQRPQWETSVADSNLTGAELERVLDECRAYRAHNKMQQPMRSDAVEGKELGQLMKPMHSLVDLVKLAEIV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VGA2-1", "uniprot_id": "TI17C_DROME", "id": "Q9VGA2-1", "name": "Probable mitochondrial import inner membrane translocase subunit Tim17 3", "aln": "--MEYNRQPCPIRIVEDCGCAFMMGTIGGSLFEFLKGFRNAPTGLQRRLYGGIDLVKMRTPSIAGSFAVWGATFSTVDCALVHYRQREDAWNSILSGAATGGILAARNGIRAMANSALVGCLVLAMIEGAGAAVATINAADKGAGIVIKPQRAQWEAILETIDPKRASSTQDFAL--AEFERVLDKCRASREPNLLQDIP----VKSHERDSKQKPFYSLLDLVKLSQMF", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: *:*** *::* * ** ** .** :. :*****:* : *.: :: :: :.*.*. ** ** .** : * :**.**:* :* :*. *: * * .*: :*.::** * . : . ", "identical_positions": 44, "similar_positions": 39, "identity": "19.13%" }, { "cls_id": "homologset.agr.HGNC:17316", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O35094-1", "uniprot_id": "TIM44_RAT", "id": "O35094-1", "name": "Mitochondrial import inner membrane translocase subunit TIM44", "aln": "-MAAAALR---------GGWCRCPRRCLGSGIQFLSSHNLPRGGSSYQISRPGGELTLTKS--YSS-GSRKGFLSGLLDNIKQELAQNKEMKESIKKFRDEAKKLEESDALQEARRKYKTIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKGGEKLGKTAAFKAISQGVESVKKEIDESVLGHTGTYRRPERLRKRTEFAGAKFKESKVFE-ANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMK-MKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDRFLHQCETDIIPNILEAMISGELDILKDWCYEATYNQLAHSIQQAKALGLQFHSRILDISNVDLAMGKMME--QGPVLIVTFQAQLVMVIKNPK-GEVFDGDPDKVLRMLYVWALCRDQEELN--PYAAWRLLDISASSTEQIL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O35857-1", "uniprot_id": "TIM44_MOUSE", "id": "O35857-1", "name": "Mitochondrial import inner membrane translocase subunit TIM44", "aln": "-MAAAALR---------GGWCRCPRRCLGSGIQFLSSHNLPHG-SSYQISRPGRELTLTKS--YSS-GSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYKSIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKSGEKLGKTAAFKAISQGVESVKKELDESVLGQTGPYRRPERLRKRTEFAGAKFKESKVFE-ANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMK-MKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDHFLHQCETDIIPNILEAMISGELDILKDWCYEATYSQLAHPIQQAKALGFQFHSRILDISNVDLAMGKMME--QGPVLIVTFQAQVVMVIKNSK-GEVYDGDPDKVQRMLYVWALCRDQEELN--PYAAWRLLDISASSTEQIL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43615-1", "uniprot_id": "TIM44_HUMAN", "id": "O43615-1", "name": "Mitochondrial import inner membrane translocase subunit TIM44", "aln": "-MAAAALR---------SGWCRCPRRCLGSGIQFLSSHNLPHG-STYQMRRPGGELPLSKS--YSS-GNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFE-PNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMK-MKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMME--QGPVLIITFQAQLVMVVRNPK-GEVVEGDPDKVLRMLYVWALCRDQDELN--PYAAWRLLDISASSTEQIL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VDZ7-1", "uniprot_id": "Q9VDZ7_DROME", "id": "Q9VDZ7-1", "name": "Mitochondrial import inner membrane translocase subunit TIM44", "aln": "-MKATSCRPIPFINFRIVRYFYRPRRLNKYYDIYRIAALVRDRACLFTCQQASQNLQQQQPRFYSAPGRRAGFFSQFFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKERVGDVLEDASKSHLAKKVTE---ELSKKARGVSDTISDTSGKLGQTSAFQAISNTTTTIKKEMDSASIENR-VYRAPAKLRKRVQLVMS--DSDRVVE-PNTEATGMELHKDSKFYESWENFKNNNTYVNKVLDWK-VKYDESENPVIRASRLLTDKVSDVMGGLFSKTELSETMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGVYLDSKILDIENIELAMGKVME--QGPVLIITFQAQQIMCVRDQK-SQVVEGDPEKVMRVHYVWVLCRDRNELN--PKAAWRLMELSANSSEQFV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q01852-1", "uniprot_id": "TIM44_YEAST", "id": "Q01852-1", "name": "Mitochondrial import inner membrane translocase subunit TIM44", "aln": "MHRSTFIR----------TSGTSSRTLTARYRSQYTGLLVARVLFSTSTTRAQG-------------GNPRSPLQIFRDTFKKEWEKSQELQENIKTLQDASGKLGESEAYKKAREAYLKAQ----RGSTIVGKTLKKTGETMEHIATKAWESELG-------KNTRKAAAATAKKLDESFEPVRQTKIYKEVSEVID----DGESSRYGGFITKEQRRLKRERDLASGKRHRAVKSNEDAGTAVVATNIESKESFGKKVEDFKEKTVVGRSIQSLKNKLWDESENPLIVVMRKITNKV----GGFFAETESSRVYSQFKLMDPTFSNESFTRHLREYIVPEILEAYVKGDVKVLKKWFSEAPFNVYAAQQKIFKEQDVYADGRILDIRGVEIVSAKLLAPQDIPVLVVGCRAQEINLYRKKKTGEIAAGDEANILMSSYAMVFTRDPEQIDDDETEGWKILEFVRGGSRQFT", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: * .* . : :. * . :. : *..* * :.:*:::.*:.::: : :* **:. :.**. : : : * : : * : . .. :*.*. : : * :..:.. : :* :: :*: : :.: . *:* : * .. . . :.....: :. ::**::.. . . . * :***:* .* . * :*:** **:*::** *.. ::: :**:*.:. * :. . *:*::**: : *::.:**.* *:.:. * : * .. ..:**** .:::. .*:: : ***:: :** : :. * .:: ** :: *. .: ** :::: .*::::: ..:.*: ", "identical_positions": 74, "similar_positions": 167, "identity": "15.64%" }, { "cls_id": "homologset.agr.HGNC:17317", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JKW1-1", "uniprot_id": "TIM22_RAT", "id": "Q9JKW1-1", "name": "Mitochondrial import inner membrane translocase subunit Tim22", "aln": "--MAAAKAGASAPEAAG------SAE-APLQYSLLLQHLVGDKR-QPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9CQ85-1", "uniprot_id": "TIM22_MOUSE", "id": "Q9CQ85-1", "name": "Mitochondrial import inner membrane translocase subunit Tim22", "aln": "MAATAPKAGGSAPEAAG------SAE-APLQYSLLLQYLVGDKR-QPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y584-1", "uniprot_id": "TIM22_HUMAN", "id": "Q9Y584-1", "name": "Mitochondrial import inner membrane translocase subunit Tim22", "aln": "MAAAAPNAGGSAPETAG------SAE-APLQYSLLLQYLVGDKR-QPRLLEPGSLGGIPSPAKSEEQKMIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCGGFAAFSAAIDYYLR-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FA60-1", "uniprot_id": "E7FA60_DANRE", "id": "E7FA60-1", "name": "Mitochondrial import inner membrane translocase subunit TIM22", "aln": "MAAPAKSTDASLSVTAGHSANVSSAENVSLQYSLILDHLIGDKR-QIKDLNPTVMGALPSPQKTDEQKMIERGMESCAFKSLIACVGGFVLGGAFGVFTAGIDANVGLDPKDPLRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESHRGKSDWKNAVYSGCITGGAIGFRAGLKAGVLGCGGFAAFSAAIEYYLR-------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IN78-1", "uniprot_id": "TIM22_DROME", "id": "Q8IN78-1", "name": "Mitochondrial import inner membrane translocase subunit Tim22", "aln": "MSVLPNAGNNESSVTAP------KMFGDPDLDRMAMEYVGNMQRYRENIIIPKSNG--PVKIKTNEEKFIETAVESCGFKCTMACVMGYGLGAALGLFSASVNPNM-ADPFANEKKQTAREVFREMRSTTHSYAKNFALIGCVFSAVECTIESHRGVTDWKNGTYAGGITGGLIGLRAGVKAGIIGGLGFAAFSTAIDYYMYSR-----------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q12328-1", "uniprot_id": "TIM22_YEAST", "id": "Q12328-1", "name": "Mitochondrial import inner membrane translocase subunit TIM22", "aln": "MVYTGFGLEQISPAQKKPYNELTPEEQGERGAEMIMNFMTSCPG---KSVVSGVTGFALGGVLG--LFMASMAYDTPLHTPTPANTAATATAGNIGVG--GISRTVQQISDLPFR-QQMKLQFTDMGKKSYSSAKNFGYIGMIYAGVECVIESLRAKNDIYNGVTAGFFTGAGLAYKAGPQAALMGGAGFAAFSAAIDLYMKSEDGRPPQNDFKE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : ::.: . . : . * : . . :: .. * . . .. :*: .:. .: . : : : :* . * ****. :* ::: .** :** *. .* *.. :* :**. :. :** :*. :* ******:**: *: ", "identical_positions": 33, "similar_positions": 57, "identity": "15.35%" }, { "cls_id": "homologset.agr.HGNC:17318", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0AB32TWM0-1", "uniprot_id": "A0AB32TWM0_DANRE", "id": "A0AB32TWM0-1", "name": "", "aln": "----------------------------------------------MKSSKYPSNTLLELTVVFLFIQNSRMETEAASMMATRAMTEGCPLGQFPCGNMSVCLPQVLQCNGHKDCKNGADEE--HCGDNSGWADIFDRTIKKAE----------------------------PQDLPNDCYLQQYPQSCSCKKTEVECVD--VNLHVVPILSSNVTWLSLKNNRIRNLDDYIFSKYTQMQRLFLQNNIIETVSSRAFSRLFT--LQRLFLSQNNITYLGPGVFRDLHKLDWLVLDHNPLKHITRDTFIGLRSLTYLSMVNVSLMRLPNSSLCQHMPLLTWLDFAENDVELLNYSTLM-TCTELTVLTFHDNNIKTLPENTFHSLGSLAELDLSCNRISKLPKNTFKSLKYLKKLNISHNPLLHIHTGHFDHLVQLQSLSLEGIEIPNITTKMFLPMGNLSHIYFKDFQYCSYAPHVRKCKPNTDGISSVEDLLASLVLRVSVWVMAFITCFGNLFVIGMRSFIRA-ENNLHAACIKVLCFADCLMGVYLFFLGIFDVKFRGEYNRNALIWMDSVECRTIGFLAMLSSEVSVLLLTYLTLEKFLVIVFPFS-HLRPAKLQTVLILAFIWFL--GFVIAAVPLLNEDLFG-NYYGRNGVCFPLHSDRLEKPTAKGYSTGIFLGLNLVAFLVIVISYSSMFCSIYKTGINATDVRSRLHKDVAVANRFFFIVFSDALCWIPIFLVKTLSLMKVEIPGTINSWVVIFILPINSALNPILYTLTTSFFREQVELLLCRWQRRSATKKDRKSVTSSTIYMETSRNPEYPAKNSLPRLSLADMDNQYG---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F8W5N7-1", "uniprot_id": "F8W5N7_DANRE", "id": "F8W5N7-1", "name": "", "aln": "----------------------------------------------MRSLQS-AATASALELCLILFTTSITTAKAGQEHRP---SEDCPLGHFPCGNVSICLPQVLHCNNQKDCPNGADED--NCGDNSGWADLFDRTFKRGY----------------------------LQELATDCQVEQYPDVCRCINTEIHCVH--ASLRSIPQVSANVTSLSLKSNKIRTLPDEAFIKYIKLQRLFLQDNCINTVSIQAFSGLYK--LQKLSLSQNSISLLSPGVFRDLRKLKWLILDDNPITTIAANTFAGLSSLFFLSMVNTSLEALPSARLCAHMPFLSWLDFEGNSITTLGLSTLL-DCEHLTVLSLRANLIKSLPENTFQSLRMMGDLDLSNNSIKELPVGIFKDLRSLQSLNLSQNPLDHIHPGQFNHLIQLQSLGLEGVEIPNIQTSMFRPMDNLSYIYFKKFQYCSYAPHVRKCKPNSDGLSSFEDLLANVVLRVSVWVMAFITCFGNLFVIGMRTVLRA-ENNLHAFCIKVLCCADCLMGVYLFFVGIFDVKFRGEYNKNAKVWMESLECRTIGFLAMLSSEVSVMLLTYLTLEKFLVIVFPFS-HLRPSKCQTFTVLVSIWLL--GISIAAVPLLNEDTFG-NYYGLNGVCFPLHSERLEKPVAKGYSTGIFLGLNLLAFLIIVVSYSSMFYSIYKTGIRATELPGRLHRDVAMAHRFFFIVFSDALCWIPIFMVKILSLLEVEIPGTITSWVVIFILPINSALNPILYTLTTSFFREQVEHLWGHWQRQPRLKQGRKSLTSSVIYMDPSR-PSFYHRSYIPHSSILDIDASYR---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8WXD0-1", "uniprot_id": "RXFP2_HUMAN", "id": "Q8WXD0-1", "name": "Relaxin receptor 2", "aln": "--------------------------------------------MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEE--NCGDTSGWATIFGTVHGNAN----------------------------SVALTQECFLKQYPQCCDCKETELECVN--GDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCN--LQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP-KQMCAQMPQLNWVDLEGNRIKYLTNSTFL-SCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKA-ENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFS-NIRPGKRQTSVILICIWMA--GFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q91ZZ5-1", "uniprot_id": "RXFP2_MOUSE", "id": "Q91ZZ5-1", "name": "Relaxin receptor 2", "aln": "-------------------------------------------------------------MWLLLHVILLTEVKDFALADSSMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADED--NCGDTSGWTTIFGTVHGNVN----------------------------KVTLTQECFLSQYPQHCYCRENELECVK--ADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHN--LQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALP-ETLCAQMPQLNWVDLANNGIKYITNSTFL-TCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKA-ENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFS-NLRLGKRQTAVALASIWVV--GFLIAAVPFTREDYFG-NFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLHKHRRKPIFKVKKKSLSASIVWTDESS-LKLGVLSKIALGDSIMKPVSP----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VBP0-1", "uniprot_id": "Q9VBP0_DROME", "id": "Q9VBP0-1", "name": "", "aln": "----------------------------------------------MVYGRSIAVGFCLMTVVLLLAAVIFYLSLG-----------PCPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNLT-LRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFH--LERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRN--VQLPKIPTLYEVYLDFNRIEYIGEETFS-QLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSS--LMEPLNISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRD-ENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLP-YYGSYSGTCFPLHIHEAFPMG-WLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLT----LLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRN--QIFLRGWKKITSRKRAEAGNGNVATTTTGTATGSSQHPDDFTIFAKAAMRCH-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "X2JJX6-1", "uniprot_id": "X2JJX6_DROME", "id": "X2JJX6-1", "name": "", "aln": "MSIAIMPHLPITFTLAILLAIASNEGAQGVESATRTAIEAIRTGIGTKPETEIADATEAEAPVREVISLLGIIDGAESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVDAKYWDHLYRKQPFGR---------------------------HDNLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFE-AEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTFP-FPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK-PRDTEKVRIVLRLLLLWGIS--FGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKG-WEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHS--GRENVVATRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNETRSQTQTAYESGLSVSLAHLGGGVGGGSGRKRMSHRQMSYL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * . * *.. : *:*: *:. ** :.:** * * * : . ::: * : *.: : * . : : *: * :. :* * *. * :..* :. * .* ..* *.* * : : : : * * : : ::* * : : * : : . : * * : * * : .:* : : : * * :..: * *: * : : : ::. * * . : : : .* :* . * ** . .** * * **:** .** . :** .**:* :: **.:*: * . : .* : :: *. :* ***.** :. * :*.:* : * * * * *: * : * ::*: :: :::: :. *: : * :* : :* : : : . .*.*:.*: . ** :*: :* : ::.* . * :: :* : : .* ** :** :* **:*::::* : :*. : :*:.::.**:***:**:***:** ::: . . : . : . ", "identical_positions": 127, "similar_positions": 177, "identity": "15.05%" }, { "cls_id": "homologset.agr.HGNC:17321", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6IMK2-1", "uniprot_id": "Q6IMK2_RAT", "id": "Q6IMK2-1", "name": "Transcription factor Sp7", "aln": "MEQEIWTLCLPLSPSSLDPESSPLG--KLLRMASSLLEEEAHYGSSPLAMLTAACSKFGGSSP-----------------LRDSTALGKGGTKKPY---TDLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGAQDPGLLVPKGHSSSDCLPSVYTSLDMSHPYG---------------------------------------SWYKAGIHAGISPGPGNTPTPWWDMHPGG-NWLGGGQG-----QGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGAGKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTH---------------------------------------GEPGPGPPPSGPKELGEGRSVGE------------------------EEANQPPRSSTSPAPPEKAPGGSPEQSNLLEI---------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VI67-1", "uniprot_id": "SP7_MOUSE", "id": "Q8VI67-1", "name": "Transcription factor Sp7", "aln": "-------------------------------MASSLLEEEAHYGSSPLAMLTAACSKFGGSSP-----------------LRDSTTLGKGGTKKPY---ADLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGAQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYG---------------------------------------SWYKAGIHAGISPGPGNTPTPWWDMHPGG-NWLGGGQG-----QGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGAAKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTH---------------------------------------GEPGPGPPPSGPKELGEGRSVGE------------------------EEANQPPRSSTSPAPPEKAHGGSPEQSNLLEI---------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8TDD2-1", "uniprot_id": "SP7_HUMAN", "id": "Q8TDD2-1", "name": "Transcription factor Sp7", "aln": "-------------------------------MASSLLEEEVHYGSSPLAMLTAACSKFGGSSP-----------------LRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYG---------------------------------------SWYKAGIHAGISPGPGNTPTPWWDMHPGG-NWLGGGQG-----QGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTH---------------------------------------GEPGPGPPPSGPKELGEGRSTGE------------------------EEASQTPRPSASPATPEKAPGGSPEQSNLLEI---------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "M9PJG1-1", "uniprot_id": "M9PJG1_DROME", "id": "M9PJG1-1", "name": "", "aln": "MLTDMTPTAGQLYGSQIPAMGMNISNIATHLQKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSS-SGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGS-PQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQQQQQHQQQQQQQHQQQQQQHQQQQQQHHQQQQQHHHQQFGQQQHPHAHHLHHHAHHAHHLATGGSPGLDPSSLVDIKPPMVXGSLGPFLFTN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..: :. .:*****:* *.*:...** :*.: *..*:. . ** : * .*. :*:. *..*... . *. *. :. * * .:. * . . **:. * *: :: .** *. ::* .... : *****... .**. * . .: . . .:. ::. *.. . : .: *. . : . **:. .. *.. : .:*.. * *: : * ***::******** ****.*.. **** ***************:*********************************:**:**** **:*:* :*.*** *****:** :** * *.** ..*. * * * *: :. .:. .* * : . .. *. * .. *. ", "identical_positions": 155, "similar_positions": 128, "identity": "21.29%" }, { "cls_id": "homologset.agr.HGNC:17325", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VCZ9-1", "uniprot_id": "HYPDH_MOUSE", "id": "Q8VCZ9-1", "name": "Hydroxyproline dehydrogenase", "aln": "----------------MIWTRLPLYGPSKPSTGGWQP----------LRFDG-GAFHVKGTAELARALLVLRLCAWPPL-VTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAKTSEVWYEENLSAMLRCVDLSRALVDAHGPARNSLMQLKVTALASTRLCKELSAWIQRPRGSSELSPERLAEAMDSGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGGPWVWNTYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHGPP---CHLMVASHNEESVRQATKRMWELG-IPLDG-PVCFGQLLGMCDHVSLALGQAG--YMVYKSIPYGCLEEVIPYLIRRAQENRSVLQG--ARREQALLSQELWRRLLG---RTA-----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q2V057-1", "uniprot_id": "HYPDH_RAT", "id": "Q2V057-1", "name": "Hydroxyproline dehydrogenase", "aln": "----------------MIWTRLPLYGHSKPSTGGWQP----------LRFDG-GAFHLKRTAELARALLVLRLCAWPPL-VTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRLDSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPR---CHLMVASHNEESIRQATRRMWELG-IPLDG-PVCFGQLLGMCDHVSLALGQAG--YMVYKSIPYGCLEEVIPYLIRRAQENRSVLQG--ARREQALLSQELWRRLLG---RTA-----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UF12-1", "uniprot_id": "HYPDH_HUMAN", "id": "Q9UF12-1", "name": "Hydroxyproline dehydrogenase", "aln": "----------------MLRTCYVLCSQAGPPSRGWQS----------LSFDG-GAFHLKGTGELTRALLVLRLCAWPPL-VTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPM---CHLMVASHNEESVRQATKRMWELG-IPLDG-TVCFGQLLGMCDHVSLALGQAG--YVVYKSIPYGSLEEVIPYLIRRAQENRSVLQG--ARREQELLSQELWRRLLPGCRRIPH----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9QIL9-1", "uniprot_id": "A0A8M9QIL9_DANRE", "id": "A0A8M9QIL9-1", "name": "Proline dehydrogenase", "aln": "----MCSLLRPPALSRLICVRLKTMAASQFPAAKRSGELNNPSPAAYLRFEDPQAFRVKSLWELIRALGVFRLCSFPVL-VNNCGKLMSFSRRVLGKRCFCMVLRPSVYAQFVAGETEGEIADSMQKMSSLGLHPMLAVPIEEDLG--ESTGEKRYDDNLSAMLECVFMS----HSNGWSNNPMMQLKITALVSPELCVKLTSLLKTELYDLNL----LVKAMD-GEEVLFPGLTESENTHLLFGLRRLNKIGEAS-VNKVRVLVDAEYTYMNPALSLITMAMMKKFN---QQSAWIWNTYQCYLKESRNLLLDAVQTSINQSFCFGVKLVRGAYMDKERKLAEKEGRTDPIHESWEHTNDSYNGCLELMLKLIAEKPER---YMMIVATHNEESVRRAVTHMAELG-LHRDGNSVCFGQLLGMCDHVSLTLAQHG--FSVYKSVPYGSVDDTLPYLVRRAQENRTVLQG--IRKERDLLRQELHRRLKEKISRSTKRNCAGNQTKGQVGKDF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P09368-1", "uniprot_id": "PUT1_YEAST", "id": "P09368-1", "name": "Proline dehydrogenase, mitochondrial", "aln": "MIASKSSLLVTKSRIPSLCFPLIKRSYVSKTPTHSNTAANLMVETPAANANGNSVMAPPNSINFLQTLPKKELFQLGFIGIATLNSFFLNTIIKLFPYIPIPVIKFFVSSLYCGGENFKEVIECGKRLQKRGISNMMLSLTIENSEGTKSLSSTPVDQIVKETISSVHNILLP-----NIIGQLESKPINDIAPGYIALKPSALVDNP---HEVLYNFSNPAYKAQRDQLIENCSKITKEIFELNQSLLKKYPERKAPFMVSTIDAEKYDLQENGVYELQRILFQKFNPTSSKLISCVGTWQLYLRDSGDHILHELKLAQENGYKLGLKLVRGAYIHSEK------NRNQIIFGDKTGTDENYDRIITQVVNDLIINGEDSYFGHLVVASHNYQSQMLVTNLLKSTQDNSYAKSNIVLGQLLGMADNVTYDLITNHGAKNIIKYVPWGPPLETKDYLLRRLQENGDAVRSDNGWPLIKAIAKSIPKRVGL-----------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . .. . :. .: :: ::* .* : : : : * .:: : . : .**. *: . :: .: :: *: . .. : : : .* : . :. :.. :. : :: : :: * . .: . . : : . *:: : * : :* : .: : : : : . .*:* *::: : : : : . . :*:*******:..*: . : . *. .*. : :: : : ::**:** :* .. : . : :******.*:*: * : * :*:* :. **:** *** .::. : :.: :*: ", "identical_positions": 51, "similar_positions": 135, "identity": "9.94%" }, { "cls_id": "homologset.agr.HGNC:17326", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "E9Q079-1", "uniprot_id": "E9Q079_MOUSE", "id": "E9Q079-1", "name": "", "aln": "MKPLYVVFGLWLLIGCFLSGECHRGPRGQRDPRKPLAPSTHHPHSR-HTQPDPKHGQFG--LPPFLPMSSGFGKTSSFTLYSPSFEVKVQPPSYTVHILGSILGQMRAISPQRNSPARPPPTVKANTIPETIAE------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O09133-1", "uniprot_id": "SMR2A_MOUSE", "id": "O09133-1", "name": "Submaxillary gland androgen-regulated protein 2, isoform alpha", "aln": "MKALYMVFVLWVLIGCFLSGECHRAPRGQHGPRRTLAPSTHHRHYHLYPLPDPNHVQFG--VPPFLPTSSGFCKPHSLSLYAPPFEIVIQPSSIIVTIPGLILTLSSDPSPQRNCPARTPPRVKANIIPGPITAQLLPKLKIPLIILDDSRK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V685-1", "uniprot_id": "G3V685_RAT", "id": "G3V685-1", "name": "", "aln": "MKSLYLIFGLWILIGCFQSGEGVRGPRRQHNPRRPQDLSTLRHYFCLQSDPNGVQMEETTSIPLTIQPPSRIVDLPGILTIITVGQLGTIEYH--CQLTGPHPGPLSNPPTQLHSTE-----------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P13432-1", "uniprot_id": "SMR1_RAT", "id": "P13432-1", "name": "SMR1 protein", "aln": "MKSLYLIFGLWILLACFQSGEGVRGPRRQHNPRRQQDPSTLPHYLGLQPDPNGGQIGVTITIPLNLQPPRVLVNLPGFITGPPLVVQGTTEYQYQWQLTAPDPTPLSNPPTQLHSTEQANTKTDAKISNTTATTQNSTDIFEGGGK------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P02814-1", "uniprot_id": "SMR3B_HUMAN", "id": "P02814-1", "name": "Submaxillary gland androgen-regulated protein 3B", "aln": "MKSLTWILGLWALAACFTPGESQRGPRGPYPPG-PLAP----------PQPFG---------PGFVPPPPPPPYGPGRIPPPPPAPYG--------------PGIFPPPPPQP---------------------------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.* :: ** * .** .** *.** * . * * : . . . ..* ", "identical_positions": 17, "similar_positions": 13, "identity": "11.18%" }, { "cls_id": "homologset.agr.HGNC:17327", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9BTA9-1", "uniprot_id": "WAC_HUMAN", "id": "Q9BTA9-1", "name": "WW domain-containing adapter protein with coiled-coil", "aln": "MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSK------------------------------------------------------SHPSSGDHRHEKMRDAGDPSP---------------------------------PNKMLRRSDSPENKYSDSTGHSKAKN-----------VHTHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTS-----------DAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMA--VNSFPKDRD----YRREVMQATATSGFASGMEDKHSSDAS--------------------------SLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCT-----------TPSTSSASGLN-PTSAPPTSASAVPVSPVPQSPIPP-LLQDPNLLRQLLPALQATLQLNNS-------NVDISKINEVLTAAVTQASLQSIIHKFLTAGPSA-FNITSLISQAAQLS-TQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVP--------------IKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQ----GHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASN--------------------ATVVPQNSSARSTCSLTPALAAHFSENLIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q924H7-1", "uniprot_id": "WAC_MOUSE", "id": "Q924H7-1", "name": "WW domain-containing adapter protein with coiled-coil", "aln": "MVMYARKQQRLSDGCHDRRGDSQPFQALKYSSK------------------------------------------------------SHPSSGDHRHEKMRDAADPSP---------------------------------PNKMLRRSNSPENKYSDSTGHNKAKN-----------VHTQRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTS-----------DAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKLA--VNSFPKDRD----YRREVMQATATSGFTSGMEDKHSSDAS--------------------------SLLPQNILSQTSRHNDKDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTASLPAQKTERKESAPGDKSISHSCT-----------TPSTSSASGLN-PTSAPPTSASAVPVSPVPQSTIPP-LLQDPNLFRQLLPALQATLQLNNS-------NVDISKINEVLTAAVTQASLQSIIHKFLTAGPSA-FNITSLISQAAQLS-TQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVP--------------MKPLISTPPVSSQPKVSTPVVKQGPVSHSATQQPVTADKQQ----SHDPVSPRSLQRLSSQRSPSPGPNHT-CSSNAST--------------------ATVVPQNASARPACSLTPTLAAHFNDNLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7ZUK7-1", "uniprot_id": "WAC_DANRE", "id": "Q7ZUK7-1", "name": "WW domain-containing adapter protein with coiled-coil", "aln": "MVMYARKQPRLGDGCTDRR-DSQPYQTLKYSSK------------------------------------------------------SHP---DHRHEKMRDSNDATP---------------------------------PCKMLRRSDSPDNKHMDNTGHGRAKA-----------IHPHRGREREGGTSISPQENSHNHSSLHSSNSHS-----NPNKSS-----------DTPFEPADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEATKTAAVVNSFPKDRD----YRREAMQATPAS---------YSSTKS--------------------------SIATE----------------------------------------KPSSLTPS------------------------------------------------------------------SSSAAVSGLDVPNSASSASGSTVPVSPVMQSPAPPTLLQDPSLLRQLLLALQTALQLNNA-------SVDMAKINEVLTAAVTQASLQSILHKILTAGPSA-FNITTLLSQATQLSNQVAQQSSQSPMSLTSDASSPRSYVSPRISTPQTNTAS--------------LKPPLSTTPVSSQTKINAMTVKSSSLPPPSSQQPLSTEKHH----DNG-NSPRTLQRQSSQRSPSPGPNHMGSNSSSSSNNGGGGGGQGPGVVSGAMPPGSVPPGTAPGRATCSFTPTLAAHFNENLIKHVQGWPAEHVEKQASRLREEAHTMGSIYMSENCTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VX88-1", "uniprot_id": "WAC_DROME", "id": "Q9VX88-1", "name": "WW domain-containing adapter protein with coiled-coil homolog", "aln": "MVMHARKPQRMNDGYFEKHTSHTSYQSSKYSSSKRDYERDRSSNYRDRDLSPGAGGGGGGGSAGGGGGGSGNGGGPLNNGNSYRSQSPDIDSPSSRSHDLRDRSDHRGGGGGNGRGGSGERYSFMQKMRDRDRDVYKKDKYSDKRDRRGNDRDSESSYRTNHDRDRRGGGGSGGGSGKLCSSRENDKRSGSDDRDRDRDRDLRDLRDKRDRGSDRDRDMYKKDKYADKRERSDRGERTARYGDWSEHVSSSGKMYYYNCKTEISQWEKPKEWVDRERNLPRDQHREKDYRDKDRDRDRDDRFSRSTYKHSNSSRDNSRLRWNYDNDGGPPSHRRRLDGRHNDNADMDISGDSTPTSEASYSLSGTPTTHGGGPGGGGPGGGGGSNSDQPMGNALPRLSSHPTANSSASVATGTGATGGLHYGSGTGGGPVTGATMLPTMSGMLNSNSSNSAGGSSSNASSSSLRNSVVGHIGSTSGTTVPTLGSQDPHQHHLNSNAPLPPGAKGKDQALLMRQKMHLGLGVLDVQSHHGVNSVGSVSDGTNHAYNSVNNSVSGSLRDNSVNSPLYMHHSMSPSLNFTKSPIPTIVGHTNNMSIAYTCNPPFGLKATLDGGVMVANASPATPGGNASSGSSGANSSQSIVPGMGPVCGISVITSMGSNSGTLCEGPPTPTQELDLSGSALEQQQLAAAAAAATASSLQLQAAQQAQQQRKLDGTSSATLSS-----------------LQSCVSSSGQAANLRGPEISPKLAKYFRADLIAHVTNWHAEVLERQAQKCCEDTHLFGDITCTRICAELKCARSLVRSTEINATLQEQKIMYLRHQIRRIEESKTQNAFMSDDT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:*** *:.** ::: . .:*: ****. .. . * ..:** * . * **.:. :.: *.*.: : : . * .:: .*:. ::..:: *:....:. : *.. . .*****:***** *****:**:*********::**:. . : .. :*** : *.. : : :* :.. . : .. *:: ..: .* ::.. *. . * .*:.* :. . *::: : : :*: :*. . .:*: ::.:: : *::* :: : .** *. :.: : . : . : :.*:.*.: .. ... :** *: . : * . . ::* . . : . . : . :: ::: :. :** ::*:: . . .:. *. . :. .::* ** :* :** ** .* *: *:**.: *::* :* : :. *:*** ***** **:***:**:*::**:**:.:*: *.**:** ", "identical_positions": 129, "similar_positions": 207, "identity": "15.16%" }, { "cls_id": "homologset.agr.HGNC:17328", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5M834-1", "uniprot_id": "DTBP1_RAT", "id": "Q5M834-1", "name": "Dysbindin", "aln": "MLETLRERLLSVQQD------------------------FTSGLKT------LSDKSKEAKVKSRPRTAPYLP--------KYSAGLDLLSRYEDTWAALHRRAKECADAGELVDSEVVMLSAHWEKKRTSLAELQEQLQQLPALLQDVESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAHARHLEDYKKSKRKELEAFKAELDTEHAQKILEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGHLQIAERREPMGSMSSMEVNVDVLEQMDLMDLSDQEALDVFLNSGGEDNTVISPGLE---MESNPSQNEMNLQIPNPSESASQPPASPSACTDLDT-------------ADAPLIQADEEEVQVDTALVTLNTDRKSTPGVSDDSDQCDSTQDI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WZ8-1", "uniprot_id": "DTBP1_MOUSE", "id": "Q91WZ8-1", "name": "Dysbindin", "aln": "MLETLRERLLSVQQD------------------------FTSGLKT------LSDKSREAKVKGKPRTAPRLP--------KYSAGLELLSRYEDAWAALHRRAKECADAGELVDSEVVMLSAHWEKKRTSLNELQGQLQQLPALLQDLESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAQAQHLESYKKSKRKELEAFKAELDTEHTQKALEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPMGSMSSMEVNVDVLEQMDLMDISDQEALDVFLNSGGEDNIVMSPGVE---MESNPNQNEMSLQIPSPSESASQPPASPSACTDLDT-------------ADAPLIQSDEEEVQVDTALVTLHTDRKSTPGVSDDSDQCDSTQDI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96EV8-1", "uniprot_id": "DTBP1_HUMAN", "id": "Q96EV8-1", "name": "Dysbindin", "aln": "MLETLRERLLSVQQD------------------------FTSGLKT------LSDKSREAKVKSKPRTVPFLP--------KYSAGLELLSRYEDTWAALHRRAKDCASAGELVDSEVVMLSAHWEKKKTSLVELQEQLQQLPALIADLESMTANLTHLEASFEEVENNLLHLEDLCGQCELERCKHMQSQQLENYKKNKRKELETFKAELDAEHAQKVLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDISDQEALDVFLNSGGEENTVLSPALG---PESSTCQNEITLQVPNPSELRAKPPSSSSTCTDSATRDI-------SEGGESPVVQSDEEEVQVDTALATSHTDREATPDGGEDSDS-------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZWE6-1", "uniprot_id": "DTB1A_DANRE", "id": "Q7ZWE6-1", "name": "Dysbindin-A", "aln": "MFENFREKLQTVQQD------------------------FTSGIKT------LSDKSKEAKVKKKQRRDEYLP--------QYSAGVELLSRYEDTWVALHKRAKESAKSGETVDGEVVMLCAHWEKRRGAVLELQEQLQQIPTFLSDLETITSRIAHLEADFEEMESRLVYLEDLCAQCEHQRFKQFQILQLENYKKKKRKELESCKAELDAEHAQKVLEMEHAQQVKLKERRKYFEEAFQQDMEQYLSTGYLQITDRRDPLGSMSSMEVNVDLLEQMDLTDVSDHEALDVFLSSVGEESSAVSPDAGGPSLEPGSSPSDISLKVPSQSELRHNISSISSSCTDTVSGTTEGPDEEESSSGDSPLVQSDEEEVHADTALMGLPETEALKS--SDDSDTQAP----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VVT5-1", "uniprot_id": "DTBP1_DROME", "id": "Q9VVT5-1", "name": "Dysbindin protein homolog", "aln": "MFGNLKKKLSSAIQEGLVISENLQQQYRQRVSSGNSGSSQASGITTPISPLGLNESLSSSRSSSLSLSAPFQLTDGVPSHLNVAAGCSLLAKYEDDWQQIHGANEKNAEKAAQIANQISGIQDQASHQHRIMSELNSSLAGIPTLIAQLQNSSQVLNSLEEMGKQLEIELEKLEDLREECELQEFILEQQFQLSRHKQKKLNELEQYRQQIAQKHQSKIKDQEQTLLKLQRERQAVFDDAFREDMEEYKQRGQLTKIQTTS-----NKLALEEVVLEAN---EVETKDALEQFLNG--------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*: .::::* :. *: :**:.* *.:. .:: . : :** .**::*** * :* :. *. . : .:: : : .::: : **: .* :*::: :::. : ** :::* .* **** :** :. : :*. :*:.* :*** : :: :* .* : *:: :**: *::**::***:* . * * : . ..: :: :** ::. ::**: **.. ", "identical_positions": 57, "similar_positions": 97, "identity": "14.04%" }, { "cls_id": "homologset.agr.HGNC:17329", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8R4L0-1", "uniprot_id": "SLAP2_MOUSE", "id": "Q8R4L0-1", "name": "Src-like-adapter 2", "aln": "-MGSLSSRGKTSSPSPSS--SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED--PLDDA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3ZMV1-1", "uniprot_id": "D3ZMV1_RAT", "id": "D3ZMV1-1", "name": "Src-like-adapter 2", "aln": "MMGSLPSRGKNSSPSSSSSFSGPGQEPVSIQAERQKVSAVALGSFPAGEQARLSLRVGEPLTIISEDGDWWTVQSEVSGREYHIPSVYVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSIRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCALREPCVLQKLGPLPGKDTPLPVTVPTSSLNWKKLDRSLLCLDAPASGEASLLSEGLRESLSSYISLTEET-ALDDA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9H6Q3-1", "uniprot_id": "SLAP2_HUMAN", "id": "Q9H6Q3-1", "name": "Src-like-adapter 2", "aln": "-MGSLPSRRK-SLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEA-ATGEESLLSEGLRESLSFYISLNDEAVSLDDA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IKB3-1", "uniprot_id": "A0A0R4IKB3_DANRE", "id": "A0A0R4IKB3-1", "name": "", "aln": "-MGCLISRFW-----PRSDVHRLEETVLLPDGASGSHTAVALCNFPSFRSDEHTICLGDKLNIISEDDDMLRVCSTSTGNECFIPHTYVSKVHDQWFFEGISRRNAEQLLMLPQNYSGCFLIRESQSFPGLYSLSVRQHS-GQMHTVLHYKIYQLHNGWFYIQPNHPFSTLSQLVDYYSRSSVGSFCHLTEPCRLHDSIPTAAH-SPSPVAAQKSNFNWRELSTSMIKRQLKGMDQESLVSEGLRETMNAYFYLAEES-SLED-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **.* ** . : : : . :**** .**: . :: :*: *.*:***.* * * :*.* :* .:*:** . *::**:**.:**:**:** * .*.*******: * ****:* .. . : **:* *.***:**.*. .*.:* **::**. : . * * *** *: * ..: * **:. : :**::*. *:: : . .: **:******::. *: * :: .*:* ", "identical_positions": 94, "similar_positions": 78, "identity": "35.61%" }, { "cls_id": "homologset.agr.HGNC:1733", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q69ZA1-1", "uniprot_id": "CDK13_MOUSE", "id": "Q69ZA1-1", "name": "Cyclin-dependent kinase 13", "aln": "-------------------------------------------MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGAAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRPGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVS--------SQSEQGLLLGGASAATAATAAGGTGGNGGSPASSSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRRRDGTRSGSEASKARSRHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDLKAHRSRTKSSKEPPSAYKE--------PPKAYREDKSEPKAYRRRQRSLSPLGGRD------------ESPVSHRASQSLRSRKSPSP-----------AGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSAKSRSRSPY-SSRHSRSRSRHRLSRSRSRHSSISPSTLT-LKSSLAAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASNASTPTKGNTETGASVSQTNHVKEVKKLKTEHAPSPSSGGTVKSDKAKTKPPLQVTKVDNNLTVEKATKK-TVVGKESKPAATKEEPVSTKEKSKPLTPSTGAKEKEQHVALVTSTLPPLPLPPMLPEDKDADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS--------------KSPEEKKTAAQLHSKRRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK--QYRRKLREEFVFIP--AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDLSTIKAPRKDLSLGLDDSRTNTPQGVLPPAQ-LKSQSNSNVAPVIT--GPGQPLNHSELAILLNLLQSKSSVN--MADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKSLGGVQPS-QTIQPK-----------VETDAAQAAVQSAFAVLLTQLIKAQQSKQKDAMLEERENG---SGHEAPLQLRPPLEPSTPGSGQDDLIQHQDRRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYPTGDTYVPSSDYKDNFG-SSFSAAPYVSSDGLGSSSAAAPLEARSFIGNSDIQSLDNYSTASSHTGGPPQTSAFTESFASSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPITVLTNSNDPSTGPESTHPLPAKMHNYNYGGNLQENPGGPSLMHGQTWTSPAQGPGYSQGYRGHISTSAGRGRGRGLPY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M1X9-1", "uniprot_id": "F1M1X9_RAT", "id": "F1M1X9-1", "name": "", "aln": "-------------------------------------------MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGAAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRPGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVS--------SQSEQGLLLGGASAATAATAAGGTGGNGGSPASSSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRRRDGTRSGSEASKARSRHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDLKAHRSRTKSSKEPPSAYKE--------PPKAYREDKSEPKAYRRRQRSLSPLGGRD------------ESPVSHRASQSLRSRKSPSP-----------AGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSAKSRSRSPY-SSRHSRSRSRHRLSRSRSRHSSISPSTLT-LKSSLAAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASSVSTPTKGNTETGASVSQTNHVKEVKKLKTEHAPSPSSGGTVKSDKTKTKPPLQVTKVDNNLIVEKATKK-TVVGKESKPAATKEEPVSTKEKTKPLTPSVGAKEKEQHVALVTSTLPPLPLPPMLPEDKDADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS--------------KSPEEKKTATQLHSKRRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK--QYRRKLREEFVFIP--AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDLSTIKAPRKDLSLGLDDSRTSTPQGVLPPAQ-LKSQNSSSGAPVIT--GPGQPLNHSELAILLNLLQSKSSVN--MADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKSLGGVQPS-QSIQPK-----------VETDAAQAAVQSAFAVLLTQLIKAQQSKQKDAMLEERENG---SGHDAPVQLRPPPEPSTPASGQDDLIQHQDRRILELTPEPERPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHGPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYSTGDTYVPSSDYKDNFG-ASFSAAPYVSSDGLGSSSAAAPLEARSFIGNSDIQSLDNYSTASSHTGGPPQTSAFTESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPITVLTNSSDPSTGPESTHPLPAKIHNYNYGGNLQENPGGPSLMHGQTWTSPAQGPGYSQGYRGHISTSAGRGRGRGLPY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14004-1", "uniprot_id": "CDK13_HUMAN", "id": "Q14004-1", "name": "Cyclin-dependent kinase 13", "aln": "-------------------------------------------MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVS--------SQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE--------PPKAYREDKTEPKAYRRR-RSLSPLGGRD------------DSPVSHRASQSLRSRKSPSP-----------AGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPY-SSRHSRSRSRHRLSRSRSRHSSISPSTLT-LKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLS--------------KSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK--QYRRKLREEFVFIP--AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQ-LKSQGSSNVAPVKT--GPGQHLNHSELAILLNLLQSKTSVN--MADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPK-----------VETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENG---SGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSS-SAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F092-1", "uniprot_id": "E7F092_DANRE", "id": "E7F092-1", "name": "", "aln": "-------------------------------------------MP---NPEIVGREGRGRSPPPQRSQREARRSKSRRE------------------------------------------------------RHRDGKGRSASSSSRRKRHKRGREKQ------LQQPQPWQQQDALYDGDAGTLVEYDDVS--------SQSER--FSGSPSPRTDALSVD----------RLSEAELQDCGYEAPAGREHNSSS----------RRRDGPAERIRSEKDAKRN-RSGREQDAAFKSRSGVRN---HDSNGRKPSSASQADKKESRRHKSKPKPEKDAPSAYRE--------PPQAYRDDREELRAYRRSSPSFKATADNASPYGTSYY--GYQSPPANYQLIPWRSPKKQSPTSTYYRDPEMYAAYNALNSSGKRKRSPASPYWRRSPSYGRHSPYEQG-EFAGSPYGQR--RRSRSP-TPDTRRPVKSGSRSPYPSARHSRSRSRHRVSRSRSRPSSLSPSSLT-LKSSLAAELSKQKKAKAAEAARAKNSS------------------SNASTPTKGSSSSSNAPQPSPVTNHAAKKTRPPSPPPPEKGPRTPVCSQPQSP-----------VERPAKRSADVPLPGRDAKLKEE----KKKQ-------AVKEKEKTVAPVVATHTPAANNMEHLEANDSVSSLKESSAGKKSSKPERKVRALLSDLPLPPELPGLTPASP------------LSPPDEKKTPAP---RRRPKICGPRFGEIKETEIDWGKRCVDKFEIIGITGEGTYGQVYKAKDKDTAELVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALDFKNDKGAFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK--QYRRRLREEFAFIP--LMALDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHELWSKKRRRQKQM--PEELTAPKAPRK--ELGLDDSRSNTPQGFGTAAGGHKPQGSANAAGLLDPKSANSQLTQDQLAVLLNLLQSKSSAAGGSAQFMQTVSSKMNPETLQQLSKA-LPCGLPESERPPEPPALPKTSKALPAAASGPGAPRTPPMPKPPSPPGPQQADGESSASATQTAVTMLLAQLLNVQQGAPGDGTGFDGADGGVPNTAPAPPEIRQPPEPS-PVS------PDAEGGGVPSSGTLDSLSILPPDQRPPEPPEPPPC--ADLDYRHAPESRP---------------------------AEPPRPPEPDYPP-----DGSGYGGDFG------------------RPPPPFPHAGFS--------DSYLGRMMGAGLPPHAPLGPEAFARGDHG----------MVFSGDQDHRFEYNHGPP-----------------PPPP----------------------GQPWTSPSQSLGYAAALR-----------GRGLPF", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q03957-1", "uniprot_id": "CTK1_YEAST", "id": "Q03957-1", "name": "CTD kinase subunit alpha", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSYNNGNTYSKSYSRNNKRPLFGKRSPNPQSLARPP--------PPKRIRTDSG--------------------------------------------------------------YQSNMDNISSHRVNSNDQPGHTKSRGNNNLSRYNDTSFQTSSRYQGSRYNNNNTSYENRPKSIKRDETKAEFLSHLPKGPKS-----VEKSRYNNSSNTSND-IKNGYHASKYYNHKGQEGRSVIAKKVP--------------------VSVLTQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQ---------KTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSR---ADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEE--PKPEPLVLDGLVSCHEYEVKLARKQKRPNILSTNTNNKGNGNSNNNNNNNNDDDDK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "Q9VP22-1", "uniprot_id": "CDK12_DROME", "id": "Q9VP22-1", "name": "Cyclin-dependent kinase 12", "aln": "MHASSAAATALVEYSDVSSEDFSDQEAGDLDADAGKGAGNIKKPKPAPDNQFSKGRLDAKPDKEGYDNYRSRRAEDSSDPVAAGSRQTSSSEATNPREEPSQASNTSKDELWGREIYMSSDSIDTDELEAEMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVTVTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKK--THRRRLREDFEFMP--APALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESLPPTVIASTKYQQHGATMVGDA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . :. : : . : . . : . . .. . . * : . * .. . :: . : :* . * :: :. . ::: . : . . .. :*... : * ******:****:: .* .:*****:**: *:******::****:*:.: * .: .::**:.:.: :.*::*** *:** *** . *.:...: :::**: *::* *.:::****:* ****::*:*::*::****** .: ***:************** .* . :*:*.***:* *** * .:**.. *: *:* * :* *:* ** : .:* * : :: : ..: *.* : .*:* :* * ** :* :**.. :::. : . * .*** * *:* : . . . : . . ", "identical_positions": 132, "similar_positions": 153, "identity": "8.07%" }, { "cls_id": "homologset.agr.HGNC:17330", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9CWT6-1", "uniprot_id": "DDX28_MOUSE", "id": "Q9CWT6-1", "name": "Probable ATP-dependent RNA helicase DDX28", "aln": "---------MALAGPSRLLALAVRLLLEPRRNLVVRGSDQSLPVVRVPRALQRRQEQRQSGRGSLQRPVLVRPGPLLVSARRPELN-QPARLTLGRWERAPLASRGWKHRRSRQDHFSIERVQQEAPALRNLSSRGSFVDLG--LEPRVLLALQEAVPEVVQPTSVQSKTIPPLLRGRHLLCAAETGSGKTLSYLLPLFQRLLRGSDLDSRSFTAP------RGLVLVPSRELAEQVQAVAQSLGGYLGLQVIELGGGLGMSRLKLQLYRRPAADVLVATPGALWKALKSQLIS-----LQHLNFIVLDEVDTLLDESFLELVDYILEKSPIAESPAELEDPFNPKAQLVLVGATFPEGLNQLLSKVTSPDSLTTITSSKLHCLMPHVRQTFMR-----LKGADKVTELVQILKQQDKASKTEPSGTVLVFCN-SASTVNWLGYILDDHKIQHLRLQGQMPASMRAGIFQSFQKGSQNILVCTDIASRGLDSVHVEVVINYDFPPTLQDYIHRAGRVGRVGSEVPGSVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVGDPLPQKA-----------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A7Q5-1", "uniprot_id": "D4A7Q5_RAT", "id": "D4A7Q5-1", "name": "Probable ATP-dependent RNA helicase DDX28", "aln": "MRLFCIKRNMALAGPTRLLSLAVRLLLEPRRNIVLRGSDQSLPVVRIPRALQRRQEQRRSDRGSFQRPVLVQPGPLLVSAKRPELN-QPARLTLGRWERAPLASRGWKHRRSRQDHFSIERVQQEAPAMRNLSSRGNFVDLG--LEPRVLLALQKAVPEIVQPTSVQSKTIPPLLRGRHILCAAETGSGKTLSYLLPLFQRLLKGPELDSRSSTAP------RGLVLVPSRELAEQVQAVAQSLGRYLDLQVIELGGGLGMNRLKLQLGKWPSADVLVATPGALWKALKSQLIS-----LHHLNFIVLDEVDTLLDESFVELVDYILGKSPIAESPAELEDPFNPKAQLVMVGATFPEGLNQLLSKVTSPDSLTTITSSKLHCIMPHVRQTFMR-----LKGTEKVTELIQILKQHDKANKAEPSGTVLVFCN-SASTVNWLGYILDDHKIQHLRLQGQMPASMRAGIFQSFQKGSQNILVCTDIASRGLDSIHVEMVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVTSFVTHPWDVSLVQKIELAARRRRSLPGLTSSVRDPLPQQD-----------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NUL7-1", "uniprot_id": "DDX28_HUMAN", "id": "Q9NUL7-1", "name": "Probable ATP-dependent RNA helicase DDX28", "aln": "---------MALTRPVRLFSLVTRLLLAPRRGLTVRSPDEPLPVVRIPVALQRQLEQRQSRRRNLPRPVLVRPGPLLVSARRPELN-QPARLTLGRWERAPLASQGWKSRRARRDHFSIERAQQEAPAVRKLSSKGSFADLG--LEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGSGKTLSYLLPLLQRLLGQPSLDSLPIPAP------RGLVLVPSRELAQQVRAVAQPLGRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLIS-----LEQLSFLVLDEADTLLDESFLELVDYILEKSHIAEGPADLEDPFNPKAQLVLVGATFPEGVGQLLNKVASPDAVTTITSSKLHCIMPHVKQTFLR-----LKGADKVAELVHILKHRDRAERTGPSGTVLVFCN-SSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQSFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRVGSEVPGTVISFVTHPWDVSLVQKIELAARRRRSLPGLASSVKEPLPQAT-----------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VPT3-1", "uniprot_id": "Q9VPT3_DROME", "id": "Q9VPT3-1", "name": "", "aln": "-----------------MLNLSVVLRVQSSRHVASYATAAAAAVKTKPPKAKSKGKKQK--------------GEPLISCRRSQFDLTQYEQTDAKFGSLSLASKGWLHNKSKGDFFILNASVRGEELQQEMQTVDEFLESTGMQIHPQLLENLRVELGIKLLTGIQKQGMPVVHGNEHCLIAAETGCGKTITYLLPIVDKLLQKEVVTERKLNTP------RVLILTPGRELATQIAGVTEKLTQGTNLKVQSLLGGN--TKQLMMNPQFEEVDILVATLGALSKLVTTGIYR-----MEQVRHLVLDEADTLLDDTFTDKLSYFLRR-----FPFHLVQKEDAGTQMILASATMPTNTREILHKVIDVDTIREVVSPHLHRLMSHVTQKFLR-----LSKADRPATLLSLVKHDLAKRRP-----LIVFSN-KSTTSDFVSIFLNNSGVNCLNLNGDMLMKIRLGRFEQFQNGHCDVLSTTDVGSRGLDTTRARHVVNFDFPLHVSDYIHRCGRIGRVGNMDKALVTNLISSRREIDVVQRIEHAARTGGLLPDVNANIRNIINKRIVAEMKAAGMPVPALGSLNGHTPQEEAF--", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P53166-1", "uniprot_id": "MRH4_YEAST", "id": "P53166-1", "name": "ATP-dependent RNA helicase MRH4, mitochondrial", "aln": "----MSLFFKPVISPQWSFPVLLKIGVRSYAGGPRTKHKGNSPLASVPTGSSNKNRKQKAKGK----------KGNKKNDPDQAFNFGEYGGLKKDVEMNMDSTNKLIQKISNFDQLLILPPVR--DAVKEIISKESLKLQD--SRKKTSENIIPSPIQTVAIKRISKNLMDPKLQ--IHAIAAETGSGKTMAYLIPLIDYLKRQELETPELWETLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKN--RIDILVTTPGKLLNLFSIRMITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKR-------------IPNINHLIFCSATIPQEFNKTMQRLFP--TVVPIMTPRLHKLPFALDFKVINSALSPFKGSKIKALAQTLYAISNDDTEPGFEKRCIIFVNEKKNVPEIVNLLNKKFGHNAIGLTGEDTFEERSEKIMPFLSPPRPLSEVVAQSTSPPTSLKKFEIPDSNIVIGKLKNTNSNGTAPSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTDSKTKSWAKALPKIIKKHQRLS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : . .: * . : .::: . :: ::. . :. * : : : ::: : .: . :... : *****.***::**:*:.: * : * ::*.* :**. *: ... .* . . . *:**:* * * : .. : : :: .:****.***** :: : : : :::: .**:* : : :: :: : :.:** : : ..:. :. :. : : .. ::* * . .. : :. : .. : : * *: * : * . : . .: : : : :: . : * . . .::: :.. *:.: : : : ", "identical_positions": 49, "similar_positions": 147, "identity": "8.19%" }, { "cls_id": "homologset.agr.HGNC:17333", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K3V1-1", "uniprot_id": "SPAT4_MOUSE", "id": "Q8K3V1-1", "name": "Spermatogenesis-associated protein 4", "aln": "MAAAGQAEECLPLPAAESSKT-SLPTPPAVPAGKKPKKCLVYPHPPRSSRLSRSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTSLKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQDDLANFTDYIYQMRLPLVPRNTVSKSIKNNIRLSELLSNPNVLSNELKIEFLILLQMLQRKLSRKLNPG-------WFDVKPTVGEITIDRLPAHSYKRRYKSRGSKEKAAQPLSKSDNDGNARKEIHVKQSGNPCENTENL---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "M0RCM3-1", "uniprot_id": "M0RCM3_RAT", "id": "M0RCM3-1", "name": "Spermatogenesis-associated protein 4", "aln": "MAAAGRAEESLPLPAAESSKT-TLPTPPAVPAARKPKKCLVYPHPPRSSRLCPSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTSLKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQDDFANFTDYSYQMRLPLVPRSTVSKSIKNNIRLSELLSNPNILSNELKIEFLFLLQMLQRKLSRKLNPGKPSLEKGWFDIKPTVGEITVGHLPAHSYKHKYKSKVSKERAVSSLSKSGNDVQPHREIHVKQNGKPCDATAKPMINVEETMKDTEEVALKKSCH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NEY3-1", "uniprot_id": "SPAT4_HUMAN", "id": "Q8NEY3-1", "name": "Spermatogenesis-associated protein 4", "aln": "MAAAGQEKGYLTQTAAALDKSPSLSPQLAAPIRGRPKKCLVYPHAPKSSRLSRSVLRWLQGLDLSFFPRNINRDFSNGFLIAEIFCIYYPWELELSSFENGTSLKVKLDNWAQLEKFLARKKFKLPKELIHGTIHCKAGVPEILIEEVYTLLTHREIKSIQDDFVNFTDYSYQMRLPLVSRSTVSKSIKDNIRLSELLSNPNMLTNELKAEFLILLHMLQRKLGRKLNPE-------WFDVKPTVGEVTLNHLPAQASGRRYNLKVKRGRVVPVLPNIGSGGSSHREIHVKQAGQHSYYSAMKPIRNMDKKP------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****: : *. .** .*: :*.. *.* :*********.*:****. *****************:.******:*:**********:*.*******************:*****:*************************:*:******:**:*****:.***** ********.*.*******:************:*:**** ***:**:******.***** ***:******:*:.:***:: ::*: : .: :.. *.: ... ..::****** *: . : ", "identical_positions": 200, "similar_positions": 64, "identity": "61.73%" }, { "cls_id": "homologset.agr.HGNC:17337", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2AJB9-1", "uniprot_id": "A2AJB9_MOUSE", "id": "A2AJB9-1", "name": "", "aln": "MKVILLTAALLALVSIPWLQAVWLGRLDPKQLLGPWYVLAVASRAKDFMVEKDMKNVEGVVVTLTPDNKLRVESSRHGPGGCHQSTVELLKQESRWVFENPSLGILDYRVLGTNFKDYAVVFTQLEFGDEVFNTVSLYSRTEMASHEAMQLFTKWSQGLGFLSQQQAQLQKDLTCAHKILQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P62502-1", "uniprot_id": "LCN6_HUMAN", "id": "P62502-1", "name": "Epididymal-specific lipocalin-6", "aln": "MGGLLL-AAFLALVSVPRAQAVWLGRLDPEQLLGPWYVLAVASREKGFAMEKDMKNVVGVVVTLTPENNLRTLSSQHGLGGCDQSVMDLIKRNSGWVFENPSIGVLELWVLATNFRDYAIIFTQLEFGDEPFNTVELYSLTETASQEAMGLFTKWSRSLGFLSQ-----------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* :** **:*****:* **********:************** *.* :******* ********:*:**. **:** ***.**.::*:*::* *******:*:*: **.***:***::********* ****.*** ** **:*** ******:.****** ", "identical_positions": 119, "similar_positions": 28, "identity": "65.75%" }, { "cls_id": "homologset.agr.HGNC:1734", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A453-1", "uniprot_id": "D4A453_RAT", "id": "D4A453-1", "name": "E2 ubiquitin-conjugating enzyme", "aln": "WETRADPAPLPHKPRPTPHPQPRPLDVTEKAPKAAAATPQRAAQPCPPLRTQASAELFRPEATAASGASETQGACAAGRGKKTTLPGVPRGRARRHIPDPVEASHRRILDPAVARRCISGPAAAARSRIRGPGVARRRIRGPKEARRRIRGREPVRRRIRGPAAAARRRVRRGPGRAEASAGRAAAPERVEPSGSPGGGGGGGAEEEGGGSPPAGARPGPSRELAPVPRPGPAPAPGPSAAAAVTAMARPLVPSS--QKALLLELKGLQE--EPVEGFRVTLVDEGDLYNWEVAIFGP-PNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVK--TKAPAPDEG--SDLFYDDYYEDGEV---EEADSCFGD--------EEDDSGTEES---------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CFI2-1", "uniprot_id": "UB2R1_MOUSE", "id": "Q8CFI2-1", "name": "Ubiquitin-conjugating enzyme E2 R1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARPLVPSS--QKALLLELKGLQE--EPVEGFRVTLVDEGDLYNWEVAIFGP-PNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVK--TKAPAPDEG--SDLFYDDYYEDGEV---EEADSCFGD--------EEDDSGTEES---------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P49427-1", "uniprot_id": "UB2R1_HUMAN", "id": "P49427-1", "name": "Ubiquitin-conjugating enzyme E2 R1", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARPLVPSS--QKALLLELKGLQE--EPVEGFRVTLVDEGDLYNWEVAIFGP-PNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVK--TKAPAPDEG--SDLFYDDYYEDGEVE--EEADSCFGD--------DEDDSGTEES---------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A140T8I4-1", "uniprot_id": "A0A140T8I4_MOUSE", "id": "A0A140T8I4-1", "name": "E2 ubiquitin-conjugating enzyme", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGPLVPSS--QKVLLLELKGLQE--EPVEGFRVTLVDEGDLYNWEVAIFGP-PNTYYEGGYFKAHLKFPIDYPYSPPTFWFLTKMWHPNIHETGFVCISILHPPDDNPQGGELPSERWNPTQNVRTILLSVISLLNEPNTSSPANVDASVMYRKWKESKGKDHEYTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVK--TKAPAPDEG--SDLF--DYYVDGEV---EEADSCFGD--------EEDDFGPKSPDPRP-----------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9VUR4-1", "uniprot_id": "Q9VUR4_DROME", "id": "Q9VUR4-1", "name": "UBC core domain-containing protein", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTAASTSQHATSSSTMMAGSGSLATSSSAAAPTTTPSSSAVRALAMEYKSLQE--EPVEGFRVKLINDDNLFEWEVAIFGP-PDTLYQGGYFKAHMKFPHDYPYSPPSIRFLTKVWHPNVYENGDLCISILHPPVDDPQSGELPCERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRRWRDSQGKDNEYPNIIRKQALAANAEAKREGIVVPMTLEDYCLKP-TRKPTTESGLDANFYDDDFDLETEDD--LPSDDDFDE--------DDDDDEDEDEDEDSATAPISKNNGGSSKCKNNGLVREAAAAGADDAESADDSGKGETT---", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P14682-1", "uniprot_id": "UBC3_YEAST", "id": "P14682-1", "name": "Ubiquitin-conjugating enzyme E2-34 kDa", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSRKSTASS----LLLRQYRELTDPKKAIPSFHIELEDDSNIFTWNIGVMVLNEDSIYHGGFFKAQMRFPEDFPFSPPQFRFTPAIYHPNVYRDGRLCISILHQS-GDPMTDEPDAETWSPVQTVESVLISIVSLLEDPNINSPANVDAAVDYRKNPE------QYKQRVKMEVERSKQDIP-KGFIMPTSESAYISQSKLDEPESNKDMADNFWYDSDLDDDENGSVILQDDDYDDGNNHIPFEDDDVYNYNDNDDDDERIEFEDDDDDDDDSIDNDSVMDRKQPHKAEDESEDVEDVERVSKKI", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : ..** * : : * : :.: .*:: * ::.::: *::.:: :: *.**:***:::** *:*:*** : * . ::***::. * :****** . .:* .* .* *.*.*.*.::*:*::***::** *******:* **: : :* : :: :. :: : .*. :* : * : * .:.. ::: . : * *. :.: ::* :. ", "identical_positions": 63, "similar_positions": 90, "identity": "11.41%" }, { "cls_id": "homologset.agr.HGNC:17340", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V6H2-1", "uniprot_id": "G3V6H2_RAT", "id": "G3V6H2-1", "name": "Pre-mRNA-processing-splicing factor 8", "aln": "-------------------------------------------------MAGVFPYRGPGN----PVPG-------PLAPLPDYMSEEKLQEKARKWQQLQ-----------------AKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKT-EDPDLPAFYFDPLINPISHRHS--VKSQEPLPDDDEEFELPEFVEPFLKDTP-LYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQ-------LTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP--SQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNP-KGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEG-EVYSADREDLYA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99PV0-1", "uniprot_id": "PRP8_MOUSE", "id": "Q99PV0-1", "name": "Pre-mRNA-processing-splicing factor 8", "aln": "-------------------------------------------------MAGVFPYRGPGN----PVPG-------PLAPLPDYMSEEKLQEKARKWQQLQ-----------------AKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKT-EDPDLPAFYFDPLINPISHRHS--VKSQEPLPDDDEEFELPEFVEPFLKDTP-LYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTVTEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQ-------LTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP--SQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNP-KGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEG-EVYSADREDLYA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6P2Q9-1", "uniprot_id": "PRP8_HUMAN", "id": "Q6P2Q9-1", "name": "Pre-mRNA-processing-splicing factor 8", "aln": "-------------------------------------------------MAGVFPYRGPGN----PVPG-------PLAPLPDYMSEEKLQEKARKWQQLQ-----------------AKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKT-EDPDLPAFYFDPLINPISHRHS--VKSQEPLPDDDEEFELPEFVEPFLKDTP-LYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQ-------LTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP--GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNP-KGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEG-EVYSADREDLYA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2B4I2-1", "uniprot_id": "A0A8M2B4I2_DANRE", "id": "A0A8M2B4I2-1", "name": "Pre-mRNA-processing-splicing factor 8", "aln": "-------------------------------------------------MAAPFPYRGLPG----PMPPGVPPPPPAVAPVPDYMTEEKLQEKARKWQQLQ-----------------AKRYSEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQMELDPDEDSSVTDWLYEHQPLKDTTKYVNGTTYRRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKT-EDPDLPAFYFDPLINPISHRHS--VKSQEPLPDDDEEFELPEYVEPFLKETP-LYTDNTANGIALLWAPRPFNLRSGRTRRAIDVPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLSKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSESWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAIYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETAEGECNVMLESRYEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDTATESAHPIRLYCRYIDRIHIFFRFSADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTIQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKFWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGAKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQ-------LTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGTSPPDNPQVKEIRCIVMVPQWGTHQTVHLP--NQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKVMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNP-KGYLPSHYERVQMLLSDRFLGFFMVPGQVSWNYNFMGVRHDPNMKYDLQLANPKEFYHEVHRPSHFLNFASLQEG-EIYNADREDMYA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z8U0-1", "uniprot_id": "A1Z8U0_DROME", "id": "A1Z8U0-1", "name": "Pre-mRNA-processing-splicing factor 8", "aln": "MSIPPYMIPQNAWAAQLMAQQAYAAAHAQQAQLHAQQQMANQIQQIPPPGAPLPPAGGHTNGIPIPVGGQGPGLGQIPTPKPDILTEEKLQEKALKWQHLQ-----------------SKRFAEKRKFGFVDTQKEDMPPEHIRKIIRDHGDMTSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVQVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNVLDVEPLEAIQIELDNDEDNAVYKWFYDHRPLVDT-QFVNGTTYRKWNLSLPQLATLYRLANQLLTDLVDNNFFYLFDPKSFFTAKALNMAIPGGPKFEPLIKDHNVGDEDWNEFNDINKVIIRQPIRTEYRIAFPYLYNNMPHFVHLSWYHTPNVVYIKT-EDPDLPAFYFDPLINPISHRNAN-SKIQEPLPDDDEDFTLPDDVQPFLQDTP-LYTDNTANGIALLWAPRPFNMRSGRSRRAIDVPLVKCWYKEHCPPGHPVKVRVSYQKLLKYYVLNALKHRKPKPQKKRYLFRSFKATKFFQTTTLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDSHVQYRLNNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPIPIENMILRYVKMKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLIPVYEVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPSDTEPPPLLAYKWCQGINNLQDVWDVGEGECNVLLESRFEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFSSFITQYYGLVLDLLVLGLHRSSEMAGPPQMPNDFLTFQDTVTETAHPIRLYCRYVDRIHLFFRFSAEEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTIGWESTFVSVYSKDNPNLLFNMSGFECRILPKCRTQNEEFTHRDGVWNLQNEITKERTAQCFLRVDDESLGRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHDEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFPAYKWNVSRPSLLADTKDTMDNTTTQKYWLDIQLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGCKTLIQQAMAKIMKANPALYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNTERTKIILKPDKTTITEAHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQTKEQNQ-------LTATTTRTTNKHGDEIITSTTSNYETQTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKETGYTYILPKNILKKFVTISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMPPQWGTHQTINLP--NTLPTHQYLKDMEPLGWIHTQPNELPQLSPQDITTHAKIMQENSNWDGEKTIVITCSFTPGSCSLTAYKLTPSGFEWGSKNTDKGNNP-KGYLPSHYERVQMLLSNKFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHELHRTSHFLLFSNLEDGGDGAGADREDVYA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P33334-1", "uniprot_id": "PRP8_YEAST", "id": "P33334-1", "name": "Pre-mRNA-splicing factor 8", "aln": "----MSGLPPPPPGFEEDSDLALPPPPPPPPGYEIEELDNPMVPSSVNEDTFLPPPPPPPSNFEINAEEIVDFTLPPPPPPPGLDELETKAEKKVELHGKRKLDIGKDTFVTRKSRKRAKKMTKKAKRSNLYTPKAEMPPEHLRKIINTHSDMASKMYNTDKKAFLGALKYLPHAILKLLENMPHPWEQAKEVKVLYHTSGAITFVNETPRVIEPVYTAQWSATWIAMRREKRDRTHFKRMRFPPFDDDEPPLSYEQHIENIEPLDPINLPLDSQDDEYVKDWLYDSRPLEEDSKKVNGTSYKKWSFDLPEMSNLYRLSTPLRDEVTDKNYYYLFDKKSFFNGKALNNAIPGGPKFEPLYPRE--EEEDYNEFNSIDRVIFRVPIRSEYKVAFPHLYNSRPRSVRIPWYNNPVSCIIQNDEEYDTPALFFDPSLNPIPHFIDNNSSLNVSNTKENGDFTLPEDFAPLLAEEEELILPNTKDAMSLYHSPFPFNRTKGKMVRAQDVALAKKWFLQHPDEEYPVKVKVSYQKLLKNYVLNELHPTLPTNHNKTKLLKSLKNTKYFQQTTIDWVEAGLQLCRQGHNMLNLLIHRKGLTYLHLDYNFNLKPTKTLTTKERKKSRLGNSFHLMRELLKMMKLIVDTHVQFRLGNVDAFQLADGIHYILNHIGQLTGIYRYKYKVMHQIRACKDLKHIIYYKFNKN-LGKGPGCGFWQPAWRVWLNFLRGTIPLLERYIGNLITRQFEGRSNE-IVKTTTKQRLDAYYDLELRNSVMDDILEMMPESIRQKKARTILQHLSEAWRCWKANIPWDVPGMPAPIKKIIERYIKSKADAWVSAAHYNRERIKRGAHVEKTMVKKNLGRLTRLWIKNEQERQRQIQKNGPEITPEEATTIFSVMVEWLESRSFSPIPFPPLTYKNDTKILVLALEDLKDVYASKVRLNASEREELALIEEAYDNPHDTLNRIKKYLLTQRVFKPVDITMMENYQNISPVYSVDPLEKITDAYLDQYLWYEADQRKLFPNWIKPSDSEIPPLLVYKWTQGINNLSEIWDVSRGQSAVLLETTLGEMAEKIDFTLLNRLLRLIVDPNIADYITAKNNVVINFKDMSHVNKYGLIRGLKFASFIFQYYGLVIDLLLLGQERATDLAGPANNPNEFMQFKSKEVEKAHPIRLYTRYLDRIYMLFHFEEDEGEELTDEYLAENPDPNFENSIGYNNRKCWPKDSRMRLIRQDVNLGRAVFWEIQSRVPTSLTSIKWENAFVSVYSKNNPNLLFSMCGFEVRILPRQR-MEEVVSNDEGVWDLVDERTKQRTAKAYLKVSEEEIKKFDSRIRGILMASGSTTFTKVAAKWNTSLISLFTYFREAIVATEPLLDILVKGETRIQNRVKLGLNSKMPTRFPPAVFYTPKELGGLGMISASHILIPASDLSWSKQTDTGITHFRAGMTHEDEKLIPTIFRYITTWENEFLDSQRVWAEYATKRQEAIQQNRRLAFEELEGSWDRGIPRISTLFQRDRHTLAYDRGHRIRREFKQYSLERNSPFWWTNSHHDGKLWNLNAYRTDVIQALGGIETILEHTLFKGTGFNSWEGLFWEKASGFEDSMQFKKLTHAQRTGLSQIPNRRFTLWWSPTINRANVYVGFLVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESIVFDICQILDGELDVLQIESVTKETVHPRKSYKMNSSAADITMESVHEWEVSKPSLLHETNDSFKGLITNKMWFDVQLRYGDYDSHDISRYVRAKFLDYTTDNVSMYPSPTGVMIGIDLAYNMYDAYGNWFNGLKPLIQNSMRTIMKANPALYVLRERIRKGLQIYQSSVQEPFLNSSNYAELFNNDIKLFVDDTNVYRVTVHKTFEGNVATKAINGCIFTLNPKTGHLFLKIIHTSVWAGQKRLSQLAKWKTAEEVSALVRSLPKEEQPKQIIVTRKAMLDPLEVHMLDFPNIAIRPTELRLPFSAAMSIDKLSDVVMKATEPQMVLFNIYDDWLDRISSYTAFSRLTLLLRALKTNEESAKMILLSDPTITIKSYHLWPSFTDEQWITIESQMRDLILTEYGRKYNVNISALTQTEIKDIILGQNIKAPSVKRQKMAELEAARSEKQNDEEAAGASTVMKTKTINAQGEEIVVVASADYESQTFSSKNEWRKSAIANTLLYLRLKNIYVSADDFVEEQNVYVLPKNLLKKFIEISDVKIQVAAFIYGMSAKDHPKVKEIKTVVLVPQLGHVGSVQISNIPDIGDLPDTEGLELLGWIHTQTEELKFMAASEVATHSKLFADKK----RDCIDISIFSTPGSVSLSAYNLTDEGYQWGEENKDIMNVLSEGFEPTFSTHAQLLLSDRITGNFIIPSGNVWNYTFMGTAFNQEGDYNFKYGIPLEFYNEMHRPVHFLQFSELAGD-EELEAEQIDVFS", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * . .* *. *. ** : : : :*: ::* * . : : * :*****:****. *.**:.: :. **:.:******:***:******** **** ::* **** :***:**** * ****** :**.: ** ******** ************:****.* ::: ::***:.*:: ** ::* * .*:*: :** : : ***::*::*.: ** ::.****:. * ::.*.*::**** *:**..**** *********** :**:****.*:::*:* ***:**::***:***. *: *::.**:.* *:. *: * **::*** :***.* . : . ..:: :* **: . *:* : * ** :.::* :* *** .*: ** *:.*.* *: :* ****:******** **** *: *. ::* *::*:* **:** *.:****.***:****:**********.*.************.************:**:*** **:*:: **::*:***:**.**********::**: *:*****:******:*:*** ******:***:**.. :********* ..***** *:** *****::***::****** .: :.**.****:::::***** :**.**::****.*:*:***********:**********.***:* **:::* **:* *** *..:********:*** *:**: **********::* *****:: *:** *:.***.::::. *.***** *:*******:**:***:*:**** **:.*: * *** *:****.***:******::*.***::*****.** *.* :*: *.:: ***.*:*******************:*:*** ****:*:* ****.*** ******.::*:...*:. *:**: :: ****:************ *****:*********:***.*.*.**:****:*:*** ******:***:** .*::::***.: **:*: *:. .* ******: **:***:::*:* :*..:* :.**:*:**** ** :****:****:*:****:::**********:*:.*:* *:*:: **.:*******:******.*.*** ****: * * .:: :***:* :* **:***:.:*:*.:*.: :*..*:* ************:. ****:**.*:******:* *: ***:*** *.:**.*:*:*******:****.*************:* .*:*** *** ******.******:**:*::::***.::*** .**.**:********** ***** *****::*:**.*********.****:********:* *:* :****.: ::.*****:.:********* ****:******:* ********** * :*************:**::****:***:**.************************ *********:****************************:*:**::* ***.*:**:* ***:***********.*** : . ::*:**:**** :::* :.. *:* *:*:***:*******:.**.***********:*:*******:*.******::.****** * *.***::* .*****************.**:*.*. **:*.*.**.***.*:* ***********:*******::**.***.** :**:**:*****************.***********:**:**** ************.********:******.*: :**:***.*.:.::*:.*:::***********:*****. ********** *:****:.* : :*:** .* * :.:*:**::***:**.:* *::****::**:* ***:::***:**:***** :*.*** :**::**:* .*:.: *. *:* * :*:**:. ::::**:******.*** **: : *:** ::****:**: * .*:****:****: ***:: *:*.::** *. *:*:****: :*: ** * ::::. : : :* *******.:* ::..:::**:*:: :: .. * *: **** :*:**:** .*::** :*.* * :*: *:. :.*:***::: * *::*. ***.***. .: : .*::: . * ***:*:**. *** *: * . : *:: *:::", "identical_positions": 1400, "similar_positions": 608, "identity": "57.68%" }, { "cls_id": "homologset.agr.HGNC:17341", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8K1J6-1", "uniprot_id": "TRNT1_MOUSE", "id": "Q8K1J6-1", "name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "aln": "---------------MQSVLYPWHRQVLRCSWSRLCL----------------LKRYLFTMKLQSPEFQSLFTEGLKSLTELFAKENH------ELRIAGGAVRDLLNGVKPQDVDFATTATP---------TQMKEMFQSAGIR-----MINNKGEK--HGTITARLH-EENFEVTTLRIDVTTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFN--GYADLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDRPGDHDHETLEAIAENAKGLAGISGERIWVELKKILTGDHVNHLIHLIYDLGVAPHIGLPA-NANLEEFN-KVSKNVEGFSP--KPMTLLASLFKVQDDVTKLDLRLKISKEEKNLG-LFIVKNRKDLIKATDSSEPLKPYQDFVIDSREPDATARVCELLKYQGEHGLLKEMQQWSVPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGYRMEKDELLSYIKKT------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I5ZQ33-1", "uniprot_id": "A0A8I5ZQ33_RAT", "id": "A0A8I5ZQ33-1", "name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "aln": "---------------MQSLLYPWHRQVLSCSWSRLCL----------------LKRYLFTMKLQSPEFQSLFTEGLKSLTELFAKENH------ELRIAGGAVRDLLNGVKPQDVDFATTATP---------TEMKEMFQAAGIR-----MINNKGEK--HGTIIARLH-EENFEVTTLRIDVSTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFN--GYADLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDKPGDHDRETLEAIAENAKGLAGISGERIWVELKKILTGDHVNHLIHLIYDLDVASHIGLPA-NANLEEFN-KVSKNVEGFSP--KPMTVLASLFKVQDDVTKLDLRLKISKEEKNLG-LFIVKNRKDLIKATDSSEPLKPYQDFVIDSREPDATARVCELLKYQGEHALLKEMQQWSVPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGYQMEKDELLNYIKKT------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q96Q11-1", "uniprot_id": "TRNT1_HUMAN", "id": "Q96Q11-1", "name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "aln": "---------------MLRCLYHWHRPVLNRRWSRLCL----------------PKQYLFTMKLQSPEFQSLFTEGLKSLTELFVKENH------ELRIAGGAVRDLLNGVKPQDIDFATTATP---------TQMKEMFQSAGIR-----MINNRGEK--HGTITARLH-EENFEITTLRIDVTTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFN--GYEDLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDKPGDHDPETLEAIAENAKGLAGISGERIWVELKKILVGNHVNHLIHLIYDLDVAPYIGLPA-NASLEEFD-KVSKNVDGFSP--KPVTLLASLFKVQDDVTKLDLRLKIAKEEKNLG-LFIVKNRKDLIKATDSSDPLKPYQDFIIDSREPDATTRVCELLKYQGEHCLLKEMQQWSIPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGYQMEKDELLSYIKKT------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F6NXI9-1", "uniprot_id": "TRNT1_DANRE", "id": "F6NXI9-1", "name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "aln": "---------------MWAKLFLRPSFVNRVHLTWSC-------------------RALLTMQLKTKEFESLFTDGLVGLAEIFQKNQF------ELRIAGGAVRDLLSGKRPEDVDFATTATP---------EEMKSMFQTAGVR-----MINNKGEK--HGTITARLH-EENFEVTTLRVDVQTDGRHAEVEFTTDWQKDAERRDLTINSMFLGLDGTLYDYFQ--GYEDLKNRKVRFVGSASLRIQEDYLRILRYFRFYGRVAAEPGQHEPETLEAIRENARGLAGISGERIWVELKKMLVGNHAGHLLELVYELGLAQYTGLPA-DGDVEEMK-QVWQRAHVSSP--KPMTVLAALFRKQADVENLDQRLKVSREEKNLG-LFLVKYRRDLVKGHDEHDTMKPYTDFITDSREPDTQSKVLELLKYQGENKLLDELRRWSIPRFPVSGHDLRKLGYTSGKEIGTILQELRDMWKKSRYQMSKDELLSTLSQS------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VNH2-1", "uniprot_id": "Q9VNH2_DROME", "id": "Q9VNH2-1", "name": "", "aln": "MNGPSLLVKLTTRAFLLFNGRPQNRWLKSMANSMVCSRGVSPELIAQLGKPPRMRTNPAFRKVATPEFKSIFTPELNDLVALFKKYDY------ELRIAGGAVRDILMGIPPKDIDLATTATP---------DQMKQMFEKEEVR-----MINANGEK--HGTITPRINDKENFEVTTLRIDIRTDGRHAEVMYTTDWQLDANRRDLTINSMFLGFDGTVYDYFY--GYDDLQERRVVFVGEADIRIKEDFLRILRYFRFYGRIASEENNHDKATLAAIKENAKGLARISGERIWSELQKIVPGNFGAALFLEMHRCNLFEYIGLPK-EPYLDEFD-RLCKALDQFEKPHQPILYLAGMLHSVEDAMEMHKRLKLSAYERDLA-RFITQERE---KVGSQYTTLRDYQKLCLQKYIQ--RDFVEQLLKYSGKLELYNQLKSWVKPDFPIRGNALAQRGLN-GMRLGLVMDELKLLWADSDFQLTHDDLLKWIPNVLKKIPSAPGKVKRMK---------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P21269-1", "uniprot_id": "CCA1_YEAST", "id": "P21269-1", "name": "CCA tRNA nucleotidyltransferase, mitochondrial", "aln": "------------------MLRSTISLLMNSAAQKTMTN---------------SNFVLNAPKITLTKVEQNICNLLNDYTDLYNQKYHNKPEPLTLRITGGWVRDKLLGQGSHDLDIAINVMSGEQFATGLNEYLQQHYAKYGAKPHNIHKIDKNPEKSKHLETATTKLFGVEVDFVNLRSEKYTELSRIPKVCFGTPEEDALRRDATLNALFYNIHKGEVEDFTKRGLQDLKDGVLRTPLPAKQTFLDDPLRVLRLIRFASRFNFTIDPEVMAEMGDPQINVAFNSKISRERVGVEMEKILVGPTPLLALQLIQRAHLENVIFFWHNDSSVVKFNEENCQDMDKINHVYNDNILNSHLKSFIELYPMFLEKLPILREKIGRSPGFQQNFILSAILSPMANLQIIGNPKKKINNLVSVTESIVKEGLKLSKNDAAVIAKTVDSICSYEEILAKFADRSQLKKSEIGIFLRNFNGEWETAHFASLSDAFLKIPKLETKKIELLFQNYNEFYSYIFDNNLNNCHELKPIVDGKQMAKLLQMKPGPWLGKINNEAIRWQFDNPTGTDQELITHLKAILPKYL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: :.:. : * . . :: : . ***:** *** * * ..*:*:* .. . ::. : : *: . ** * . :.:...** : *: : : ** *** *:*::* .:. : * * **:: : *. : :* **:** :** .*. . . : *. : ** **: *::*:: * : : : : : : ::. . : . . : : : : :* : : . . * : : . :. * : ** . : : : . . .:* .: ::. * : : * :*. ", "identical_positions": 59, "similar_positions": 112, "identity": "10.19%" }, { "cls_id": "homologset.agr.HGNC:17342", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I5ZZE0-1", "uniprot_id": "A0A8I5ZZE0_RAT", "id": "A0A8I5ZZE0-1", "name": "Bromodomain and WD repeat-containing protein 3", "aln": "---MAAAP-TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKNTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHVFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKT---MKFRDRPVKFTERSRPG-VQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMSGNNLTSTEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSVTGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFG-CSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQL-----GYVANGDGEVVEQVIGQQTND----------------QEESILDGIIRELQREQ-------DLRLINEGDVPHFPINRSYSVNGALSSPNMDIPSSPNIGLRR-SGQIEGVRQMHNNAPRS----------QMATERDL-MAWSRRVVVNELNSGVSRVQEECRNAKGDLEVSLYTVEKKKK--PSYPIQRNDYQP--SCGRSL--------RRTQRKRQHTYLTRSNIEHNSQASSQ----NSGVQGDSDSSSEEDETVGTSDASAEDPVVEWQSESSSSDS---SSEYSDWTADA-GINLQPPKRQTRQATQKIYSSSEDE----NVKSSEDRQKKPKQTRKKKGGL--VSMAGEPNEEWLAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGIPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINNLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIKQRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEN-PNSSDPEEDTEMVDLDSDGPGTSSG----RRAKCRGRRQSLKCNPDAWKQQCKELLSLIYEREDSEPFRQPADPHSHPAQQQ-EGESSESVPPDRQ-DPSLSEDYQDVVDTPMDFSTVKETLESGNYDSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFENRIKNIISEYKSAIQ---------------------------------SQK------------------------------------RRRPRYRKRLRSSSSSLSSSRAPSP-KGKQKQMKLQPKNDQNTSVVYARTSSPFSSPVSDAAEG-------------VSLYLLDDEGDGPFSPSSCSGYSRSGNSHDPGKAKSFRNRVLP---AKQDHSLDGPLTNVDGREPRTGAKRKLLSASEEDESMGGEEKEMKETKE---KAHLSSSESGELGSSLSSESTSGSDSDSEST------SRTDQDYVDG-DHDYSKFIQT-------------RPKRK------------------------------------LRRQHATGKRNWKTRGTGGRGRWGRWGR----------------------------------------------------------------------------WSRGGRG----------------------------------------------------------------------RGGRGRGGRG----RGGGGGRGRGRGRGGRGASRGASRTKRARVADDEFD----TMFAG------RFSRLPRIKTRNQGR-----------RTVLYNDDSDNDNFVSTEDPLNLG-TSRSGRVRKMTEKARVS----HLMGWNY---------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A2AHJ4-1", "uniprot_id": "BRWD3_MOUSE", "id": "A2AHJ4-1", "name": "Bromodomain and WD repeat-containing protein 3", "aln": "---MAAAP-TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHVFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKT---MKFRDRPVKFTERSRPG-VQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMSGNNLTSAEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSVTGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFG-CSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQL-----GYVANGDGEVVEQVIGQQTND----------------QEESILDGIIRELQREQ-------DLRLINEGDVPHFPINRSYSVNGALSSPNMDIPSSPNIGLRR-SGQIEGVRQMHNNAPRS----------QMATERDL-MAWSRRVVVNELNSGVSRVQEECRNAKGDLEVSLYTVEKKKK--PSYPIQRNDYQP--SCGRSL--------RRTQRKRQHTYLTRSNIEHNSQASSQ----TSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDS---SSEYSDWIADA-GINLQPPKRQTRQATQKIYSSSEDE----NLK-LEDRQKKPKQTKKKKGGL--VSMAGEPNEEWLAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPDGTAFPDEVGAGIPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINNLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIKQRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCSDILDTYNKIKAED-PDSSDLEEDSEMVDLDSDGPGTSSG----RRAKCRGRRQSLKCNPDAWKKQCEELLSLIYEREDSEPFRQPADPQSYPVQQQQEGESSQSVPPDRQ-DPSLSEDYQDGIDTPMDFSTVKETLESGNYDSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFENHIKNIISDYKSAIQ---------------------------------SQK------------------------------------RRRPRYRKRLRSSSSSLSSSRAPSP-KGKQKQMKLQPKNDQNTSVAYARTSSPFSSPVSDAAEG-------------VSLYLLDDEGDGPFSPSSFSGYSRSGNSHDPGKAKSFRNRVLP---AKQDHSLDGPLTNVDGREPRTGAKRKLLSASEEDESMGGEEKEMKETKE---QVHLSSSESGELGSSLSSESTSGSDSDSEST------SRTDQDYVDG-DHDYSKFIQT-------------RPKRK------------------------------------LRKQHTNGKRNWKTRGTGGRGRWGRWGR----------------------------------------------------------------------------WSRGGRG----------------------------------------------------------------------RGGRGRGGRG----RGGGGGRGRGRGRGGRGASRGSSRAKRARVADDEFD----TMFSG------RFSRLPRIKTRNQGR-----------RTVLYNDDSDNDNFVSTEDPLNLG-TSRSGRVRKMTEKARVS----HLMGWNY---------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6RI45-1", "uniprot_id": "BRWD3_HUMAN", "id": "Q6RI45-1", "name": "Bromodomain and WD repeat-containing protein 3", "aln": "---MAAAP-TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKT---MKFRDRPVKFTERSRPG-VQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFG-CSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQL-----GYVANGDGEVVEQVIGQQTND----------------QDESILDGIIRELQREQ-------DLRLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRS----------QMATERDL-MAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKK--PSYTTQRNDYEP--SCGRSL--------RRTQRKRQHTYQTRSNIEHNSQASCQ----NSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDS---SSEYSDWTADA-GINLQPPKRQTRQTTRKICSSSDEE----NLKSLEERQKKPKQTRKKKGGL--VSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEE-RNSTDAEEDTEIVDLDSDGPGTSSG----RKVKCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQ---------------------------------SQK------------------------------------RRRPRYRKRLRSSSSSLSSSGAPSP-KGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDAAEG-------------LSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLP---VKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKE---KSHLSTSESGELGSSLSSESTCGSDSDSEST------SRTDQDYVDG-DHDYSKFIQT-------------RPKRK------------------------------------LRKQHGNGKRNWKTRGTGGRGRWGRWGR----------------------------------------------------------------------------WSRGGRG----------------------------------------------------------------------RGGRGRGSRG----RGGGGTRGRGRGRGGRGASRGATRAKRARIADDEFD----TMFSG------RFSRLPRIKTRNQGR-----------RTVLYNDDSDNDNFVSTEDPLNLG-TSRSGRVRKMTEKARVS----HLMGWNY---------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PQW9-1", "uniprot_id": "A0A8M9PQW9_DANRE", "id": "A0A8M9PQW9-1", "name": "", "aln": "---MAAEPCSQIEAELYYLIARFLQSGPCQKSAQMLLQELHEYEIIPKRWSCDGEQFKRSFDDWVLLNQHIPADYLLRVCKQVGPLIDKHIPPSVPGVHSLLGTGRQSLLRTAKSSSHTLWSGSAVAALHRGRPPEPPISCAKSPNIVSIIGARQKTGVARFGHAFPSCAYQHMKMHRRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRTCAPVAVLQGHTASITSIQFSPSALGSSRFLATTGADGMVCFWQWNSFS---MKFVDKPVKFMERSRPG-VQISCSSFSSGGLFLATGGTDHMIRVYYLGTEMPVKFSDLDSHTDKVVAIQFCNNTDSLRFVSGSRDGTARIWHYQQQEWKSTVLDMTTRLPGSAVISGDDKSTKLVVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLLGHDDEVFVLEAHPFDSRILLSAGHDGNIYVWDLSKGQKIRNFFNMIEGQGHGAVFDCKFSVDGQHFACTDSHGHLLIFGFG-CSQPYEMIPDQMFFHTDFRPLIRDSNNFVLDEQTQQAPHLMPPPFLVDVDGNPHPPRCQRLVPGRENCKEEQLVPQL-----GYMANGDGEVVEQVIGQQTADES--------------QEESPLDDLIRQLQNQQ-------DERVNQAN-------PAGAEVAGGPLSP-------PNVGLRR-SGQVEGVRQMHNNAPRS----------QMATERDL-LAWSRRVVVNEVQAGIFRVMEDCRLAKGEVERSYYIIEKKRKSVPSTGSQPGDNVR--TLRRPQ--------RKAQQKR-HAYQTRSTRTRRRSGSVQSFSRNEETEVESESEAEQEEDQNENSDGTSEGETQWENDSSSSDS---SSEYSDWTADA-GINLQPPKRTTRRPARVAVSSSSEDEEGTGQGEGEAAQTTKQAEKKKKPKQ--RSVPAGELEEWLPPSWIMETIPRRSPFVPQMGDELIYFRQGHQAYVRAVSRAKAYSINPQKQPWNRLNLRDQESVKVVGIKYEVGPPTLCCLKLAILDLTSGKMTNESFSLKYHDMPDVIDFLVLQQFYNEAKERNWQPGQRFRSIIDDAWWFGSLECQEPFESEYPDSLFQCYIVRWDNGEREKMSPWDIEPIPEEAPLPEEDGDSVPVTEDELQALLYSPQEGEWGLHTRDEECERVITAIDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQNCTDILDLYNKMKSEF-SSE---EDEEETVDVDSDTPGTSTGQ---RRSNSTPQKRGVVLDINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYP-------------------------DYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPNKKSRIYSMTLSLSAFFENQIIPIISDYKSAVQ---------------------------------NQR------------------------------------RSQ----QRLMCSKR-LQSSSPNSP-KGKQKSGK---KTLQMSAKARTRKSSQDSN-VAQVDE--------------------DSQPSSSSSSSSSSSSSSSFSSEQAGANRVTRSQVTS---SKS----SGVFLPNGGRSSRR--RRAVLTE----------EGEVSECES---TSSSSSSTS----ASSSSSATSSSSSESDDS------SAEVSGFADGGDHDYSKAPQH-------------KQKGK------------------------------------APAPPPPPSPPPPAPTIDNPKRKRKGEE----------------------------------------------------------------------------EQSAEPE----------------------------------------------------------------------KRPRRTSSRE----EEEEEEEEEVDDEPEEEEEPDEEEEPEEEEEESDDE----NVISPSKRSNQRTPKSGRVNTRNQGR-----------RTVLYNDDSEEE--GPTSDPLNLG-MSRSGRVRRMTERARVS----HLMGWTH---------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VC96-1", "uniprot_id": "Q9VC96_DROME", "id": "Q9VC96-1", "name": "", "aln": "METRQPSSGDDLKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHLLEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRTKETVYCHRSLRDYCTRLNGVSLPDS-VLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTGRYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPIAVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQAQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRG--LRFISGSKDGTAHIWTFESQQWKSSKLCMTERLASCPEP---EEGKRLKVTMVAWDASDRYVITAVNDFTIKIWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPAEAPPAALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNRQMPDSNGRQSSRGNVLGSRLSTPRQGWGAAAAAPVEDQAGPSQPPAEPAAEPGQAQVQQALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVGRPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEPEHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKRSKRKPLSRRPRSSDDSSDDERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKAPYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPIDQ-QRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHSSESENEVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRIHSEGDWRADCRQLLDLMWARTDSAPFREPVDTIDFP-------------------------DYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFESHIKTVVTSWKAALRRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEEEEEETSAQATSDASSDEEERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRRRPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQDSQIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTRTSSHLGAENDHSYHLPVRNGRIIESDTDSPVIRPTRQSAKRALMDWGRGSDIEEEEEEEEEDSEEAEEILPTPTKDDLPSTSRAALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSDNEPLANNQQKNYQSPAKSSSTATVAPHPLSLRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDHNYLGNVNSSRAPRRILSRHQRNADELDTSLDVLENSRLLSAIANHRRPTSTTNSNSASNVVTRRLRGRASQANSHDEDHEEEEAAASDEGTDGGSSSQSYEDEDEDSDSEDNQPLTSYVSPSNGRPRRKAKTSSSSATTQERPLRRTRRPPSNNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDAHASSQERSQASTERDQEEEEDGTSVDSEEQQVNVSSRGRVRKPSAKARGIFKE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . :::.***:**::** :** :::*::*::**.* :::*:* . :*::..::*:: ** .::**.:*.::***:*:.:* ****:::***.***.*** : . : *: *: : . *: : .*: * * .*: *:: *: :* :********* ***:** *:**:** *:***:: :********* ::**:*:::* :**::*:.* *:::*** ::* :*:***..*:. ***::*.**. . ::*.:*.:** :.***: :.* :*.:: *: *** .*: *::**.**:*:::*.:** :*:* :* : * :: : :::** * ::*:.:. ***:***:****:** ::.*:*** * *: ::.. :: .:* ******* * :****.: :*:*:* ..:* :.* **.**::***::* *.:::*******::::**:.:* : *::* *:*****:***.*:* ** :*.******:*:**:* * : *: :* ::*****:***:**:::.*:***** ***********.******.: **:*****.*. :**:*:* * : :..* : *:. . : : * :* :* * ..* * . : . .. *. *: . .. .: .* . * .:: * : : **. *. :: : :: : *:.* . * * ::: . . : *. :: ::* . : : : . .. *::: . .. ... .: : :.**.:* **:**** **: * **:**** .*:. **.:. . * . : :*. . . * : ...*: :.***::*: ******::****** *: ** * *.:. ..:*** **::* *:::*****: ** *******::* .*:**. :*.:********:*****:* :: * :***. *:***.:* *.**:* :*.:..:..::*** * *: *:***.* * *****:*** : .*:* * .:** :*: * **.*:. ** ** *.*:* .::::: *..*. * **:* ** *. :: * **.**: *: ::*****:: ::***: **. :*. .: **. :: *:*: **:* : . *: *::: .. * : : * * * **:. *: . :: . . *: :*.:*: : ** ***:*.* .* ** : : **:*: **.* * .*** .*::* **** **.*** *..**:****:* * ***:**.:* :::.:*:*:: .*: * : : : * *. *. .:*: * . : :: :* *. : : ..: . * .* . . . . .* : .: * .. * . :* : : . .: : ::* * .* *: ::..*. :* . : . **.* : : . : . : . * : . . . : * ..: . . .. . . . . :.: : . .: * .: .: .* * .:: ::*.::: . . * * .*:** :: .. . * *:.: ", "identical_positions": 557, "similar_positions": 581, "identity": "24.59%" }, { "cls_id": "homologset.agr.HGNC:17344", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A7S4-1", "uniprot_id": "D4A7S4_RAT", "id": "D4A7S4-1", "name": "", "aln": "----------------------------------MGVPKRKASESPGGAASPAGTSKRTRAEEFTGVRFKTQLKDAQGPGPALEAFVSAAKQLPQEDMCDVVEG----------------------------------------------YIKISMECAEIFQLLS-GEKRPESEVLLIFQAFEAILLRTASDLTHFHVVGTNIVKKLLNNHMKLLCESLYASGYRMARACLDLMTAVVTQGP-EAARDVCSCFDLNKKALYALVTKR-------DSKG----VHDVRLAYIQFALSFLIAGDDNTIGQVLEI-KEFIPCIFSSGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQLLNHIAALYNWN---GVSDIVPENPESTEMSAEEAGKAMVRDLVHNFLIDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAGDELVASLVVSILKVCPDLLTKY--FREVTFSFLPRVKSTWLNNVKLLNKIYEAQPEISPAFWTREFIPLPRLLAMVMVTTVPLVCNKIMFTQALNLDSIPVKQSALSLISIILKRALKTVDHCLDKEIWQDSDVYTAEMMEEFVQLFREALSKILPDLNTVIWVWQSFKKQEIKENHEKGKKSSSKTPAASKAVHRDDAETILLKSVLLQVICLYQQVVPHVVTQYNFDFSKLLKGIISEQGPAEEAPPILQHHMLKVALELPANKFLWLKAQEGPEAEIVGGERSVFYLLMKMFVNSSHLQLKLSTQRLIMKILRDTGVFEHTWRELELWLERLDSTAEKHKETVIQFLERILLTLVVNPYSYTDKASEFVQEASTLQGAVGKQDADDVSIPISHIDDVLDMVDVLVEGSEGLDEDIGFLLNEDMILLTFPFSALVPAALEARNKLLLGTECEAGESIVAYMTAVLTDILHTQRDPLALCLLLQSYDKFEPASLL---CCQQLAQFHRYYSLWIPEQAQEALPLQVSGTSGPYTPPSSACFSTLLQTAYES--QTLGDKNVQAKLLAAVPCLPLQHMLRSAKQVLLYLKSTVENFSQLGKSVGPTLLQFLLGLLKHLVIHSEQLDTQNQQKLEAA--RAESDLFLDMESVASLELATDKTVEELLVAILKHPTLETWFLALEQKALPPHTLSPVLVKLLAAQFSAGVLQLLVAS--SPILHKLGQLGLLAKYSEAITQSVLRELRTRTVN-SAMTPKTL-PQLEALRELHPYMEGVQIREVTLALLGLPEAHLLTQQGTQCPGKERQLSSLGKTLVQLLTSSHQ--NRLQSSELLWCAEYVRGLGALLPTLAEQELDT-VFLQTLQKDPVLAPVVPADLLEYCLVRRTKAALDIASLLLQYS-STHLLKFELWCGQPGVGPSLQEHLDDFFPLIHVYLQHRMQGSFMRPTEVSSAVTPVLR-ALWRQVRDRFFHIAGPSKHALHLEALAQLIPFART-KDLRVLMDHLPNLLRTLSNHKSWIVADSVSAALAESAEELASWRKTLLRSCIQWLAVSFSGREPENENTQEQEKTMLLRLS----ELLH---AVKEVDPGDWQQFVKTGLKFRYQDLTFLRTLLDATKLLYSPESSGHTKLVQLSVMHMMLTQHSLFLPTMLTSKEEETPDSPVKETLLDLMSTVVRMCPSVCESSHFAVLLGTYSATLSILDQKILLLLRAYEQHSLSLISFRVLLWGPAAVEHHKTCRSLG----KSLWQQPSVGDILRLLDPDRMMQTILHFPQYRRLLHTEDTGEPQVFKDKTARVDLSG-------------------------------LYDPCFLLHLFGELTRPEFVVDCRKFLDSNALGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIQAPN-------------LRLPFTVALFIAKAAAQILRPEEHMYWKISKFLLSHENLNMNKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFSSPLCDEVAQNWILEILQNVAHIPRSAYEVIRDYSLLTWILHILES-RFIETQLLSNVISLLHTLWVTNLGSRAAEERSQLPCQTDCHESEKTLALHMVNEFLYVLVALTKHLRPTLASTQLMDFFWTLESVLSYRATVIKIFKDMGRFTVNQVTLSTKDVLVLLHKWSLIERDTKLQGELKAIIEQHQAKDLMKMLKDKHRPLGAARAKGPRGREKRRREREEETAEPQLEASTLEKCKDLLRATLTHWGPAVPLPGPTQESVGQAIPKSKALGSAHAAVSLVAGWVLRSLAERPLSRAEVTRLLDWLKSHILPQPMVVADLLRDSAVKTGIFKLYSRHCNAQGLVGPAQDVACKFSMVMLQLLVAQGRTPSPFHSVAEALCLDSLNEKDEAKRAPAAFLVSLYIKDIWLGAQQPDTFLAHIQTVCEASKDMALGESEALVVLCRDVGSSAQSLTHSC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q571H0-1", "uniprot_id": "NPA1P_MOUSE", "id": "Q571H0-1", "name": "Nucleolar pre-ribosomal-associated protein 1", "aln": "----------------------------------MGVPKRKASEGPSSAASPAGTVKRTRAEEFTGVRFKTLLKDAQGPGPALEAFVSAAKKLPQEDMCDVVEG----------------------------------------------YIKISMECAEIFQLLS-GEKRPESEMLLIFQAFEAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTAMVTQGP-EAARDVCSSLDLNKKALFALVTKR-------DSKG----VHDVRLAYIQFALSFLIAGDDNTIGQVLEI-KEFIPCIFSSGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAALYNWN---GITDVTPEKPE---ISAEEAGKAMVRDLVHNFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAGDDLVASLVVSILKVCPDLLTKY--FKEVTFSFLPRVKSTWLNNVKLLNKIYEAQPEISPAFWTREFIPLPRLLAMVMVTTVPLVCNKIMFTQALNLDSIPVKHSALSLISDILKRALKTVDHCLDKETWQDSDVYTAEMMEEFVQLFREALGKILPDLNTVIWVWQSFKKQEIKEDHEKGKKSSSKTPAVSKAAQHDVAETILLKSVLLQVICLYQQVVPHVIMQYNFDFSKLLKGIISEQGPSQEVPPILQHHMLKVALELPANKFLWLKAQEGPEAEIIGGERSVFYLLMKMFVNSNHLQLKSSTKLLIMKILRDTGVFEHTWRELELWLEHLDSTAEERKEAVIQFLERILLTLVMNPYSYTDKASEFVQEASTLQASMGKQDADDVSIPISHIDDVLDMVDVLVEGSEGLDEDIGFLLNEDMILLTFPFSALVPAALEARNKLLLGTDCEAGESIMAYMTAVLTDLLHTQRDPLALCLLLQSYDKFEPVSLL---CGQQLAQFHRYYSLWIPAQAQEALPLQVSSSSGPCTLPPSSCFSTLLQTAYES--QTLGDKSVQAQLLAAVPSLALQHMLRSAKQVLLYLKSTVENFSQLGRSVGPALLQSLLGLLKQLVIHAERLDAQNQQKLEAA--RAESDLFLDMESVASLELATDKTIEELLLAILKHPTLETWFLALEQKALPPHTLSPILVKLLAAHFSAGVLQLLVAS--SPILHKLGQLGLLAKYSEAITQSVLIELRTRTLN-STSTPKTL-PQLEALRELHPYMEGVQIREVTLALLALPEAHLLTQQGTQSLGKERHLSSLGKTLVQLLASSHQ--DQLQSSELLWCAEYVRGLGALLPTLAEHELDT-VFLQTLQKDPVLAPVVPEGVLEYCLARRTQTALGIASLLLQYS-GTHLVKFELWCGQPGVGPTLQEHLDDFFPLIHVYLQHRAQGSFMRPTGVSSAVTPVLK-ALWRQVRDRFFHITGPSKDALHLEALAQLIPFART-KDLHVLMDHLPNTLRTLSNHKSWTLADSVSAALAESAEELGSWRKTLLRSCIQWLAVSFSGREPEDENTQEHEKAMLVRLS----ELLH---AVKEVDPGDWQQFVKTGLKFRYHDLTFLKTLLSATKLLYGPESSGRTKLVQLSVVHMMLTQHSLFLPTMLSSEEEETPDSGVKETLLDLMSTVVRLCPSVCQSSHFAVLLGTYSATLSVLDQKILLLLRAYEQNNLSLISFRVLLWGPAAVEHHKTCRSLG----KSLWQQPSVGDILRLLDPDRMMQTILHFPQYRKLLPTEDTGEPLVFKDKTARVDLDS-------------------------------LYDPCFLLHLFGELTRPEFVVDCRKFLDSNALGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRTPN-------------LRLPFTVALFIAKAAVQILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNSPLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTWVLHILES-RFVETQLLSNVISLLHTLWVTNLGNKAPEERSQPPGQVGSQESEKMLALHMVSEFLYVLIALTKHLRPTLASAQLMNFFWTLESVLSYRATIIKLFKDMGRFTVNKVALSTKDVLILLHKWSLIERDTKLQGELKAVIEQHQAKDLMKMLKDKSRPVVAAQARGPRGR-KRRHGGLEETAEPQLEASCLEKCKDLLRATLTHWGPGDPLPGPTQGSVGQTIPKSKTLSSAHAAVSLVASWVLRSLAERPVSRAEVTRLLDWLKSHILPQPMVVADLLGDSAVKTGIFKLYNHHCSAQGLVGPAQDVACKFSTVMLQLLVAQGRKESPFHSVAEALCLDSLNEKEEAKRAPAAFLVSLYVKDMWLGAQQPDTFLAHIRMVCEAAKDVPLDEPEAIVVLCRNVDSSAQCLTRSR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60287-1", "uniprot_id": "NPA1P_HUMAN", "id": "O60287-1", "name": "Nucleolar pre-ribosomal-associated protein 1", "aln": "----------------------------------MGVPKRKASGGQDGAASSAGAAKRARKEELTGVRFKAQLKDPQGPGPGLEAFVSAAKKLPREDVYDVVEG----------------------------------------------YIKISVECVEIFQLLS-GEKRPESETMLIFQVFEAILLRTASDLSHFHVVGTNIVKKLMNNHMKLICESLYASGYRLARACLSLMTAMVTQGP-EAARDVCSHFDLNKKTLYTLVTKR-------DSKG----VYDVRQAYVQFALSFLIAGDDSTIVQVLEV-KEFIPCIFSSGIKEDRISTINILLSTLKTKVVHNKNITKTQKVRFFTGQLLNHIASLYNWN---GITDVNPENVK---VSAEEAGKTMVRELVHNFLMDLCCSLKHGINFYDASLGTFGRGGNLTLLHFLLGLKTAADDDLVADLVVNILKVCPDLLNKY--FKEVTFSFIPRAKSTWLNNIKLLNKIYEAQPEISRAFQTREFIPLPRLLAMVMVTTVPLVCNKSMFTQALNLDSTSVRHTALSLISVILKRALKTVDHCLNKEVWQESGVYTAVMMEEFVQLFREALSKILPDLNTVVWVWQSLKKQETKQDDKKGQKRSDGPPAACDAHQCDDAETILLKAVLLQVICLYQKVVPHVVMQYNFDFSKLLKGVISEQGLREEVPPILQHHMLKVALELPASKFLWLKAQEGPDAEIIGGERSVFYLLMKMFVTSSHLQLKSLTKLLIMKILRDTGVFEHTWKELELWLEHLENTMEEDKETVIQFLERILLTLVANPYSYTDKASDFVQEASMLQATMTKQEADDMSIPISHIDDVLDMVDVLVEGSEGLDEEIGFTLSEDMILLTFPFSAVVPAALEARNKLLLGTGNEAAENVVTYLTAVLTDLLHTQRDPLALCLLLQAYDKLEPPCLVP--CCQQLSRFNRYYSLWIPEQAREAWLLQAQGSPSPPALPLASSFTALLQAAYES--QALRDEHIQVQLQATMPHLSMQQVLLAAKQVLLYLRSTVENFGQLGRSVGPPLLQLFLDLLRRLVVHCEQLDAQNQQRCEAA--RAEADLFLDMESVASLELANDQTLEEVLVAILRHPTLEGWFLALEQQALPPHTLSPVLVKLLATHFSAGVLQLLAAS--APILQNIGQLGLLARYSEAITQSVLKELQNRRAGPATSPPKTP-PQLEALQELHPYMEGAQLREVTLALLSLPETHLVTQQPTKSPGKERHLNALGKTLVQLLTCSPQ--DQLQSGELLWSSEYVRGLGALLPTLAVDELDT-VLLHTLQRDPVLAPAVGADLLDYCLARRTQAALSIAALLLQES-CTHLLWFEQWCLQAGPGLGLQGDLDDFLPLIHVYLQCRTRSHFTRPAGVSSAVIPVLRKTLWRQLQSRLLSTDSPPASGLYQEILAQLVPFARA-KDLSVLMDRLPSLLHTPSSHKRWIVADSISAALEGSAEELCAWRRTLLESCVKWLIVSFSGGQQDDDNTQNQEKEMLLRLN----ALLH---ALNEVDPGDWQKFVKKGLKFRYQDHTFLKMLLTAVQLLYSPESSVRTKLIQLPVVYVMLMQHSLFLPTLLTSDGEESPDSQVKEALVDLMLTVVEMCPSVCESSHFAVLLGAYGATLSVLDQKILLLLRAYEQNKLSLINFRVLLWGPAAVEHHKTCRSLG----RSLWQQPSVGDILRLLDRDRMMQTILHFPQNRRLLPPEDT-QELIFKDK-SRVDLDG-------------------------------LYDPCFLLQLFSELTRPEFVVDCRKFLDSNALGLTVTALSSYDPQMRAIAYHVLAAYYSHLEGARFQEQSQLLYLLDVVRNGIRTQD-------------MRLTFTLALFIAKAALQILKPEEHMYLKVSNFLLSHEYLNMDKVPGFYQFFYSSDFEQKTEQKWVFGVLRQGIRDKQCYELCARRGIFHIILSFFHSPLCDEAAQNWILEILQNAAQVARSAYEIIRDYSLLTWILHILES-KFLETPLLSNVISLLHTLWVTNLGDKAVEWESQRLCQPSSQEPAKRLALHLVNEFLYVLIVLMKHLRPTLAPVQLTNFFGTLDSVLRYRATVIQAFRDMNRFTVNETVLSTKDVLVLLHKWSLIERDLKLQEDLRAAIEKAQARELMKMLKDKNKPVMPARAKGPRGR-KRRPGEAEEMADPELMASTLETCKGLLRSILTYWRPVIPGPDPTQEPVDSASPESDAPGPVYAAASLAVSWVLRSVAEHPLSRAEAAGLIGWLKSHILPHPVVVADLLKDSAVRSSIFRLYSRLCGAEGLAGPVQEVACLFNTVMLQLVAAQGRAGSPFHPAMEALSLSSLSEKDEATQASAAFLVSLYIKDIWLGAQRPDTLLTHVRMVCEAADDAPSSEEEAIVVLCKDAASAASDA----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4ILM9-1", "uniprot_id": "A0A0R4ILM9_DANRE", "id": "A0A0R4ILM9-1", "name": "", "aln": "-----------------------------------MATKRENEENITESVTKAKKGK-TDESEFSGTVFKSMLKDSSEAQKGLATFIRVAKTLPCAELYDVVEG----------------------------------------------YIKISAECSEIFALLD-EEK-PEKEMMLIFQCLEMILLRTASDLSQFSMVGANIVRRIVSKHMTLLQSSLYSKNYRFVRQCLSLLSALVSQSA-DAARDVFGQMQFG-KDLCQLARKR-------DKSG----KSDVRMAFIQFVLSFLMSGDNTTIGQILDT-KELS-EILNSGLKEDRLSIINLILSTLQTKVVQNKTITKTQKVRFFSASILAQIASLYRWN---GIVDVSVDEEE----KVEEGGKHIMRELVHNFLMDLCCSRKHGISFHDPSLGTAGKVGNLVLLQFLVRLKQATEDEMVAELVVNVLKGSPDILNRY--FKETQCSFAPRNNKTWQDNISLLKKIYEVQPVVSKAFQMNEMVPFPRLLSMVLVTSLPPVCNKVFFTQGLNVHSLVVQHTTLSLLAFILKRAQQNIEYCLDRTVWETSDIYSPAMMEEFVQLYREALSKILPDMVSIVSIWQLHSKE--KEDAAKMKNRKQKQ--SQEHSQQDDPHLILVKALLLQVMCLYQKVVPHLVTQSRFDFSKLLKGIVTESGMTQEVPPVLQYQILQLALELPASKFSWFRVQEMANPDFEKGEKSVIYLLLKMFVSSNNSYLKTSSRMLVLKVLRDSGVFEHTWKELELWLDHLTMLGLSQQETVIQFLDHVLTRVVCNSHVYTDKAASMVQEAANLQANLNGQDGDEASIPISHIDDVLDMVDVIVESSEGDIEEIGPSLTEDIILQTFPFSAVVPAVLEARNKLP-DSFKDAKGVLYEYMAAVLCDVLHCQRDPLALCLTLQHYDKELSTSDAASTPHASVVSFYHYYSQWLPKNTHHTLFISESFTDGG----SHADFTALLKTSFTEGANAFLRTSFKEALQEALATLTVSRIPVAVNQVLLYLRNYVLNFNMLLKETAAEVLSSLMMVLNALILKLLSSDTHTPVESESAGQHDEDALFLDTNQVPAENTDKQQIVLAVLKSVFKHPAVEQWFLALELSSFPPHSLNPVRLKQLCVCLTEMTLLLLESS--ADTLRDLDALELISTYLTSPQRAVLRELQEMKSN---CPKKES-LSVRALLALQEYIEPSSFKEVVSTLLLLPQKHLLAPE--------NQLSVYGRTVQKLLSDSLKRSSAVSSSCVTLSPAHLQGLAALFTSCQCVQLED-FLLQVLSREPGTAKLIQTDILLHCIQRESPSAQDIGVVLLENC-STHVLSFELWCLDPSNQKQISVQNGSFLSLLNSYLKRSTADDPTRPKDVQKSVLKVLKNALMAELWHTVQQGEAGVRTALHVEVLSSLIRLAAVNSDLIQLIKDLPAILQKPDTYERWKLADSISEKLCDDSEELHQWRKSLLSAALVWLTAVYK---KQKEPQSNHEESMLTRLR----SLLLGQIFPENMTASDWNAFVKSGLKHRYHDCNFLETLNSLVEVIYDTPDTP-KEMLPVATIHMMTTTHSLFLPTMLAIDTDSLR--LTKESLVSLLLTLVRKSPEVCNVNHFLVLLGAYEASLSTTDQKLLLVLQEYEKNNISLAEFQFVLWGPAAVEHHKTRKSLG----PSLWQKPTSEHLLSLLSADRMLNTVTHFPQRRYIIPQVNKTMIYIQEGK-RSVDLSS-------------------------------LYDPCFLLPLFSFILQPECAVDCLKFVSCQALGVTMAALSSYDSKVRAAAYQVLGSFYQHLEGARFKEKRQLLYLLDTVKNGIQKQN-------------LRVPFVHVAYIAKVAQQILRPEEHMYMVVSRFLLGTQFLDLKRVPDFFKLFYSFELEHKLEREWILSVLEEGVWDQSCYELCEMQRIYQTLLAFASTSLCDQATQIQIVRVLRQTARVNRAAYILTKEHGVLTWIVQLIEK-RYVDSKLLSSVIELLHALWFTNLGDKESKAEASSTSSEQPQTSGKCLPLPIINEFLCTLLTVIRHLRSGVSGLQLQQFLHTLSSVLVHCGTAMNAYKEAGWLTLHPHKLSCSEVLSLLQRWTALSHDASLASALQTVGNKHKVKELMGSGREK--------GQGKCHSTKHAPMEKQTENAEVLDQAVLDECKPHLRNILLHWEPKEKELSTSTSQTVSDKPASSGLS--NTTACVIFKWALKTLTESRFDDKCTLALLKWTHSTIMPHRSITDAVLSDEGVRKDLLRLFHLTAQEGTLN-----TLQLFSTVMLHLLEAHRDRLNAGHQTLIQTCLLTNTD-DEAKKETGLNLLSLYLYELWSEAQSPDLLLTHARLICSGTSSK--KPKSHILHICRDILAAFHS-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VD07-1", "uniprot_id": "Q9VD07_DROME", "id": "Q9VD07-1", "name": "Nucleolar pre-ribosomal-associated protein 1", "aln": "MAIQPNRRKRRHEETTAEQEDEGEVEVPKKLAKESDTPKKKKKKDKTKESFDESTLESTETDPADSTPSKKKSKKTKTSDTSVEQQVEVEMAEDEISRDSGIDPEESRIHFPNDFKMMHFRTKLRGNNFITELRHFLHMCSTTRPKLAAKYIEKRGKPLELAEAFERIDKTNLFHVDYLTEALHRVLMEILTNQKSHMESAVHGCRYFLKVHGGVLENQMKSMQLGHRRNALKLLTAIVCVEP-QLARQVLNSYDVLSNVTVTQKLLS-------HEKSEYQCEDTVRKAFILFILAFLVEGNTLLIRNILDR-GQLIGVLAKG-LVYDDHVTVCVVLNALRQYVLENPEIQKTKKVLVFDLECCKNLRRLYDWEGPMGLKVMFAKSKHVSKIPPNPQEAEAVSAAVHELLLVLLTSRKHGICFDAMTHYRQKQ--NKLQGRLLGSLFKPYDNPRKVDLVIQTLTACPDLGRNT--VRNCSSLLSP-VKTKPKDLPIAVAFLAQIINAVPPSALSAAFDKMTLTDFSFWIKELCLPIEALLHITGKKYLSDPDFNLRLAVLRLLLS-MMKQYSNYMNAIAVREQSKKAGNSLRKFKFDLLNHLLVHFPTIESILYSLYMFIKQKNVEGVN-------------------VLESLSITLDLVMLLCKENRAFVNKTSQI-LDYLDVLRPLYETDFDKLNQP----EELLKIQLELKSIKTILLLFPHSLNPTQPLFG-NVFKSFIKAYMLEEK-SIKSESGNILSRLFQNTGMFDSCRHEINIWIEALIGFG----PATVTNVVEILLTILCLDWRQIELPEQSVTDTAIITKNLSK-----------------------------LFAQIEQGQTVQAYVETLTLSKMMPLLLKG---------VELEEPYDEYVELVFVLLFHYHSKPEIVLQMYEDNLSKHTNYMKS-----WLPGEGNGKPKKLPHLIFDKWPLLKQMRKVSTESENMSFEQVFKMDDTENNFELQLEEGQTMLLHSSLGNPRRNMIYVQDLLFVFSHFFTSQKLSKPQAELTADFLIKFLQIASQVDGPEEVQESDDEQQDENFTQSMLHYIFNHRLWQLHPTELLSETSESRLNYVIFLRRLMEHCRSLPRFETYTANYRLHLIKTLDIALDTPVDQLGNQQQLDECVKLVDSFEFNSDQCSQMLDLLTTKVQAKDCIPNGKPNHYFDLLLRLLGRLNTLKEPIDCGKSFKLILTFYKDFGELNE--------QQLEPFELAVLEFLLNYHHHMDECDSEFFACFFTSSRKLSKSAIRLACLLLERQPRLAETFAELLPSNLEQKDLVYPLLDIALTKNYQIPLPVLQRCYQTYKNGFMKSIEKPQKAALIYREHSEASALLIALCMPKSECFDYCQKQLKLDSVELFQVRVLREIYWQGFAAAKDEKQKATVFVNYINLNVQLLALDLKKQALDLPKLEQISWNCYEWWKTNRTDDLPLDWSRLQKNPQWLNFCKSSLKLALHLG---EERLPLQDETNGLVLKLM----AFLC------------------DGMYDEYK------------------EDAQQEEDATPTLLYEMICTHSCCFDHLLGKPS------ETKTHILHLMEVLARKAPSALQSDHIPVILGSYHAKLSPADRYGLALLEHYERFDVGLDKFRPFIWGESAVAHYALRAADEDVRTRLQQQETNVAQVLALIVRETSEYTIENFPIWRSLHASQQLPSTEFQNPAKKSMSFGDNQLEQMVEQGQLDFPQDLRRICPKRETIYETCYDPAFLLPLMMHCFAPESVVWARWPVQNGLLAITFCGLSSLDKDMRLAAASCQQRYRAHFELSNFYERPLWTQAYENIQAGLADLRNSWLAQRRTHGGTPRVPLIPGLFIAHSFNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVELLRCGIKCSADLFLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIPGAVKIMLEHVGILSWLVGVIRDTEFHQFDIIEGVISILNNLWYALAASRS--------------------ELTDYDHIQLRVYRLVLQLLPLLSPRISVPGLGRLFNVLWKTGSACGQHRAVSATQMDTLLECVS------RQWPDQLASVRYVRSFGSAGACSRSEYCDWLAKDQ---------------------KLETPAVLALSS---------LREYVIDWAQAHKSESDGETKLLVEPTE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P34241-1", "uniprot_id": "URB1_YEAST", "id": "P34241-1", "name": "Nucleolar pre-ribosomal-associated protein 1", "aln": "----------------------------------------MSNHSEAYGSRDQRREKYTQGKEFEDG----TLETLESIISAVEDETLSKDYQPLIVFFQRGFG------------------------------------------------------AQLVQTWSYYAQVNNHGKFSKTTSLLTKTLRVLSSDTSTVTIGSGLIRLILTDYTKVLYRGLNNMRAQLTNPILRLLKQIVNFNNGQHIEELVSYFDFSLPILPRLLVPSKSELANGNSSADSSKHDSLRFTFIKFWLTLISNASPFVRKELLTENFKIMSNLFKFMNKADSDKLSEHILSVFINDILKEKSFKRTTKTKILNELAASKIHHFYYSS---NKNLVKKANEFFLTFGASRDFSVAFPDNCVWFKNSVADGASHGAPITVNQVEFQIHN---KLLFNTLRLFKPWEDTLQLGTLIKILENVPELVAPYSIFLTTNGNYDPKMTSYWFGITLLINKIINLK---IPQFMEKVDSNIPPATSLVIENILPSLLTKSSLVKSLQFETPIIRQLACQSIVLALK-KLEKVSTFYDQKGWRNE-----------KTILLNEFHTRIPDLPIFVSTLSNSLAS--------------------------NKDNRILPLSISIIFNYYSKMFPNLFSIN-LPSSNIYTDIMQKSKIS----------GIEFAILDNYLQFQEFNSTQTRWWNPSSGGNSLFTLLLKLASSKNASNVITTRISNLLDELTRTNVIFNISLISPVMALVNSLQGLSLQVSEIDNMEQVWKWFDETISRVVKTPYKYVDMAKEYN-------------------------------------------------------YISPFIMCLSEQWKYVDKSGNPEFLIKWLILFLRNMIFIGEDHIGIDKLVKNVFPEVSDHDVN---------------IYLKLDSFEENIKKTNSSNSLISSMKSSSFFQYISALPSK--NLMNISRLPVNKLDAAGILFRVQLLVEDDSVVYDNWFEATACELTGKIASYMVTDTEFPIIKVLERYINFALPKLAIEKRNALLMKKSRFMCNLIGAVCFETG---------HQLVEFREIIQKVVFSGENVEEYANYNELYQKEDVNAFLTSVSEYLSTS----ALTSLLMCSTKLESTRNILQKLFNEGKTIKIS-----------LVKNILNKAANEDPASIKEVNISLAKFFEENKVCVDASSDPMGKLSLSETTSLINSFVSSDLN-------YLVLKAFYRWEHFSFPSFIPSIWRIKDSPLLSIVTTAALFKHMQDKDFSAFAHETISKYGNEIAKSTYTTS-------------KSEIFDEILNMITTYIDFYDETKRNEILKCVLSQSDHKYHAATVRYIAAHNNFTYPGVETWLHKTLLYLTKYLSERKVISNSFFELLRAMAELLKLEEVPNKLNVKIINSQLEAILG--SEWIKQIKVLEYVIVLIFCVSKKSIQSQRMVQLLLSNDSYSSIMIKDND------------------------------------------------EDSSYRKFLSTMILFSLFSIDPVVNSTPIVQEK----------------------------------LLTFYSGTISSNDKLILKILETIESHTATSWTNMIFSWEFIKDEEEEILEAIG----DTRLITKEREGLILTLQKNMIKKSIDRYVLERPQVPELYTDSNTNNYDATTRCDLVK------------------------------------------------KYYDDTERSGVDMYDPLFLLLLIIHNKELVKMVKDDEGNVTYRYEFENFLDCKIFQFIICSLSDCHTVAN------------------ISYEHLSNLASSLEKKTAQMNLEKQITSKDNERKESDSDLIKYNSIYQVLIKRILYQ-------RQQNQDPINPLIWFSISRIVDLLGSPTAPLHEKAYRWVLSNSTIRSWDIPMVSDVMMSYN-----KRQQDDNKKEIDMEIYYGELSWVLTTICKG----------------------------IKTDEDYKMLEKKGVFEWLLNLINMPYLKERLRELIYFIFYKVQRVADDGGLNLISRNGIVSFFEVLNNNIKSRLPQDDILNNIGTLRNENRG-------------------------------TLNTTLRLAQEQNGIEKLLLGYNELVKSQKRLILWTEGDSDNVVKRLRK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : : . . : . .: . :: . : : :. :. . . : :: : :: : . * *:. :* : .:: . :. .... :* ::: * *::: .. ::* :: : . * :*..: ::.: : :* *. .: :: :* . . : . . . : : . .** : : * . : ::. * *:: . * .. . : : : :. . . : . : : : : *. : . : . . : : :* : .: . . : : :: .: . : : .: : . ::. : : : . .:: ::* .. : : : :.:: : : : : .: . . . . * : : * : :: .: ::. . : : . : . . : . : : : .: . : : : .. . . :: . :. : . * : . . : : : : : :. : : . : : : : : *. : .:: : . . :. :. * .. * . .. : : . : :. . :* * . . . . :. : . : .: : :. : .. : :* * ..:* *: * :*. * . * . : :: : : :: .: * .: : : . * : .: . : * .* : : .::: . : : : . :*. :: : . : :*. :.* . . : : : . . : : . :. : . : : : * .:: . : . .. . : : : : . : ", "identical_positions": 45, "similar_positions": 352, "identity": "1.84%" }, { "cls_id": "homologset.agr.HGNC:17345", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZUG8-1", "uniprot_id": "D3ZUG8_RAT", "id": "D3ZUG8-1", "name": "Ferritin", "aln": "MLSCFWFFSKHIGPALMSLPCVLHRFTAPRCLASRYPLSPLLASPRRLLASVASSQGSTG----PARVRQNFHPDSEAAINRQINMELYASYVYLSMAYYFSRDDVALYNFSKYFLRQSLEEREHAEKLMRLQNQRGGRICLQDIKKPDKDDWECGLRAMECALLLEKSVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPAAGLAEYLFDKHTLGSESKH-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D5H4-1", "uniprot_id": "FTMT_MOUSE", "id": "Q9D5H4-1", "name": "Ferritin, mitochondrial", "aln": "MLSCFWFFSKHISSALMSLPRVLHRFTAPQCLASRYPLGPLLASPRRLLASVASSQDSTR----PSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALYNFSKYFLRQSLEEREHAEKLMKLQNQRGGRICLQDIKKPDKDDWECGLRAMECALLLEKNVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPAAGLAEYLFDKHTLGSESKH-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N4E7-1", "uniprot_id": "FTMT_HUMAN", "id": "Q8N4E7-1", "name": "Ferritin, mitochondrial", "aln": "MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VYH1-1", "uniprot_id": "Q9VYH1_DROME", "id": "Q9VYH1-1", "name": "Ferritin", "aln": "MAWCFRDIRRHMC----------------------------------------------------MLVRQNFAKSCEKKLNDQINMELKASHQYLAMAYHFDRSDISSPGMHRFFLKASVEEREHAEKIMTYMNKRGGLIILSSVPQP-LPCFASTLDALKHAMKMELEVNKHLLDLHALAGKEADPNLCDFIEANFLQEQVDGQKILADYISQLEKAQNQVG---EFLFDKYMGSGMHPAK", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* ** : :*: ***** ..* :* ***:** **: **:***:*.*.*:: .: ::**: * ** *****:* *:*** * *..: :* : . * *:: *: :* .**: **:**:**..:.**:****:*: :*:***.. * *.*:: :* . . *:***.: .. ", "identical_positions": 75, "similar_positions": 57, "identity": "30.99%" }, { "cls_id": "homologset.agr.HGNC:17346", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5RKH1-1", "uniprot_id": "PRP4K_RAT", "id": "Q5RKH1-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MAATEP----PSLREQPEMDDADNSEKSVNEENGEVSEDQ----------SQNKH-------SRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVLD----ASDKEGLS-PAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKK---------RSKSRSKERTRHRSDKRKSKGAVEMMREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPTLRRRSQEKVGKARSPADEKIKSEEKGKIKDRKKSPIVNE-RSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKQRDKSRRSRSPLLN--DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPSRRRSRSPIRRRSRSPLRRSRS-PRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVK-EDKFKGSLSEG-MKVEQESSSDDNLEDFDVEEED-EEAVIEQRRIQRQAIVQKYKYLAEDSNI-SVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAG---IGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61136-1", "uniprot_id": "PRP4K_MOUSE", "id": "Q61136-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MAATEP----PSLREQAEMDDADNSEKSVNEENGEVSEDQ----------SQNKH-------SRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIE----ASDKEGLS-PAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKK---------RSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNE-RSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLN--DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRS-PRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVK-EDKFKGSLSEG-MKVEQESSSDDNLEDFDVEEED-EEALIEQRRIQRQAIVQKYKYLAEDSNI-SVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAPDMFTESDDMFAAYFDSARLRAAG---IGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13523-1", "uniprot_id": "PRP4K_HUMAN", "id": "Q13523-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MAAAET----QSLREQPEMEDAN-SEKSINEENGEVSEDQ----------SQNKH-------SRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIID----ASDKEGMS-PAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKK---------RSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLN--DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRS-PRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVK-EDKFKGSLSEG-MKVEQESSSDDNLEDFDVEEED-EEALIEQRRIQRQAIVQKYKYLAEDSNM-SVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAG---IGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0V1K6-1", "uniprot_id": "B0V1K6_DANRE", "id": "B0V1K6-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MANMDA----LAKTIAKDYVDDMESSDSVDENECVPGEDG----------AKKADNMDFARVEKHKKRKHKHRSKHKKHKHSSPDERDQKHKYKHKHKRKHRDSFRDDRECSTSYEGAADSPKRFRLDDLAALEDLEKQRAMIQAELDNELMEGSVQSGMGLILQGYNSDSED-GEVQEAVRNGEQQ------RKDLDELVTVKGNGRK---------LQQDYVNDEQFYSVLEGRT-----MSEEVTVQSHKSEKRESMTGLGIKISERPSGPSETKERRRSRSTDRSKDRS-----RRSKSPVKSKEVPSSSATSNRKSNTRPEEQ--AVDHRSSSRSSKSGSKERSTSLPEVDRDKKPVKAPLKEVSSGKENRSPSRKQG--PDRLSPTVQPRSHRSPERLPVVQNTDRASRQDRSTCHNRSPPRRGRSRSVERRRREEERQRLSSDRMRSRD--MAGAHREDSPS----ISSRRRLNHSPLRRRSRSPRRRS-------SRSPLR--HRERDRMDRRQPVRSRSQERRRRRSKER-EDMFKGSLSEG-MKAEQEDSDEEVLEDYDVDEED-EEALIEQRRLQRLAIMQKYKPVNEDSNM-SGLSDHGSPQSSTHSRSPSPDDILERVAADVKAYEQENLDTFEDNVKAKYSLVSQEKN-GANSKKPPAPDMFTESDDMFAAYFDSARLRAAG---IGKDFKENPSLRDNWTDAEGYYRVNIGEVLDKRYAVYGYTGQGVFSNVIRARDLARANQEVAVKIIRNNEMMQKTGLKELEFLKKLNDADADDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLRKYGKDVGLHIKAVRSYSQQLFLALKHLKRCNILHADIKPDNILVNEPKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLNMDLKGKLPNKMIRKGLFKDQHFDQNLNFLYTEVDKVTEREKITVMSTINPTKDLSMDMVGRQALPEDQRKKVGQLKDLLDQILMLDPAKRITINQALQHPFIQERI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB32TIC0-1", "uniprot_id": "A0AB32TIC0_DANRE", "id": "A0AB32TIC0-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MADLEMDLQSKRLNNGPENLESPQKSGNEDENGDISGEDEEEGEEEVEMNGEKQDISSKHHSSKHKKKKHKHRSKHKKHKHASEEDKNRKRKHRRKHKKHKRKEEASSSAISRKAEDGSMLLSSANLDDKALLEDLEKQRALIKAELDSQMMEGKVQSGMGLILQGYNSGSEEDEERQRARNGEQRQNSSGGRTRSPRDQIGGMGRSRRDLDTSKPSAKQQSHSHSRERAGRDSKLERATKSAKETVKERSKSKEKKRSRS---RDKSKDRGKKSQSPSIRRHSAD------------RKPDQKGRP-DRRSSPHMDEKREQARQRSD----SQGGKSQSQGSKDGQ-NVGRSENDREKRPGKSPSKDPSSGKENRSPQQRPALSPQHRRSS-SPRHRDRQSNQPRFSSVDRSSKLSHSPSRNRSLARRARSRSNERRRDSPSRKRLR----------VDGVGRSRETTP-----VRRRVSRSPLRRRSVSPRRQSRSSPRRRSRSPQRRRSVERDRFGRPRPRRSTSRNRDRRRRRSRDEDKFKGSLSEG-MKADQESSSEEVMEDFDAEEED-EEALIEQRRQQRLAIVQKYKAGNEDSNLGSMPSEPSSPQSSSRSRSPSPDDILERVAADVKEYERENVNTFEANIKAKHNLIAQEKE-GNNPKKPSAPDMFTESDDMFAADFDSARLRAAG---IGKDFKENPNLRDNWTDAEGYYRVNIGEILDKRYDVYGYTGQGVFSNVVRARDTARAGQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNEITPYLVSRFYRAPEIVIGKPYDYGIDMWSVGCTLYELYTGKILFPGSSNNHMLKLAMDVKGKMPNKMIRKGLFKDQHFDQNLNFLYIEVDKVTEREKVTVMSTINPTKDLLADMVGGQRLPEDQRKKVMQLKDLLDGTLMLDPAKRISINQALQHPFIQEKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "X2JAG8-1", "uniprot_id": "X2JAG8_DROME", "id": "X2JAG8-1", "name": "Serine/threonine-protein kinase PRP4 homolog", "aln": "MADDKS---------------YDSSNNSETEE---------------------------------RRAKHKKAKKHKKHKKSSTGKTEKDRHVHKKQKKAKKRPHRT--------------SESTNESDAPENAKLKLSQNCGLSSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQNK------MLPVLEVAS---------------------SSSESDVPADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPEAEDKGD---------------------LLPHTHSQQLVVHTKSVLKAVTSVPQPQPS------KSAAPLATATSKHANIKKSTTHNSNESDVILLDDSSGGQRTPSPTPEKRR-RHASPLPAAPRSRCRRDRRSRDR--DRSPPRRRASDQQTQVRPRSRNRNMEDLRQEINRDKQRERRDHSRDRDRRGLDRPPPPT---------DMRPGRARERDVRPSRMQRS----HSRSKFE-SDRRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKESSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAP----HNSVSYESRSTSQGSSQRERPLRTPSPTMPCPNPLISEIPKDREDMDNSTS--QKTCSAKEKRNEWDMFADQD--VDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEKM", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** . .. . *: :: ***: .******::* . ::.:: ::*:*: :: . . .* . .*: .: :. .::*: :.* .: : :: .. . :.. : .. .. :: : *. . . . : ... . . : . . . : : . . . . ...:.. .: *.*:.. ** . . . * : .. . ** . ::. : . *.:.*. * * . .* : * .: . *.*. * * . *** . .*.* *. . * .* :******* * ::*.*.:: : * *** ** :** ** :* :::* *.. : * :* : ::..* : *..: . . :. : . : . : :: :* ***::.* . : ** :* :.. .*. :*** * *** ********.***:**:** * ***********:*.** **. :**:*******:*:****:***:********.:*:******:***:******:*****:*******:****:***********:******** **: .*************** : *********** ::**:***********:***::* .****** **.***:**********.*.:**:***: **:***:**::**** *::*****. **:* *:**:*****:.**..::*::.* :::. * **:**::** ******: : *******::**** *.****::", "identical_positions": 329, "similar_positions": 244, "identity": "31.24%" }, { "cls_id": "homologset.agr.HGNC:17347", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z0M9-1", "uniprot_id": "D3Z0M9_MOUSE", "id": "D3Z0M9-1", "name": "Probable ATP-dependent RNA helicase DDX23", "aln": "MAGELADKKDRDASP-KEERKRSRTPERDRDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSVERERRHKERERDKERDRSKKERERDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKGDEDEHGDKRPKIQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQKMLEEERKKR----KQFQDLGRKMLE---------DPQERERRER---RERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPP--HILEVIDKCGYKEPTPIQRQAIP---IGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLG------IRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMG-YNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTK-EDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "G3V9M1-1", "uniprot_id": "G3V9M1_RAT", "id": "G3V9M1-1", "name": "Probable ATP-dependent RNA helicase DDX23", "aln": "MAGELADKKDRDASP-KEERKRSRTPERDRDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSTERERRHKERERDKERDRSKKERERDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKGDEDEHGDKRPKIQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQKMLEEERKKR----KQFQDLGRKMLE---------DPQERERRER---RERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPP--HILEVIDKCGYKEPTPIQRQAIP---IGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLG------IRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMG-YNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTK-EDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BUQ8-1", "uniprot_id": "DDX23_HUMAN", "id": "Q9BUQ8-1", "name": "Probable ATP-dependent RNA helicase DDX23", "aln": "MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKR----KQFQDLGRKMLE---------DPQERERRER---RERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPP--HILEVIDKCGYKEPTPIQRQAIP---IGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLG------IRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMG-YNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTK-EDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VJ74-1", "uniprot_id": "Q9VJ74_DROME", "id": "Q9VJ74-1", "name": "Probable ATP-dependent RNA helicase DDX23", "aln": "---MVNDKKRRSRSR---ERHREDRPAVGNPRDRERERDRVRERDRQFDREKER--RQRRSRSREDRNRRRSPERQRPRDNVRERSR-ERGGGAGGGGGGGAEKKAKMDTGDAPPKPLIVDDEEQQDGK----EAKVKKEPLSLEELLDKKKREEEARSKPVFLTKEQRALEAIKRRQEEVERQRAAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPPPKPDRRERGGGRDRGDRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGIIKKKRRVRRLNDRKFVFDWDAGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPK--EIIDIIDKVGYKEPTPIQRQAIP---IGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQIEEETTKFGQPLG------IRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYT-KKKYRQTVMFTATMPPAVERLARTYLRRPATVYIGSVGKPTERTEQIVYMMGENDKRKKLMEILSRKIDPPVIIFVNQKKGADVLAKGLEKLG-YNSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTK-DDSALFYDLKQCVSASPVSTCPPELMNHPEAQHKPGTVVTKKRREEKIFA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P23394-1", "uniprot_id": "PRP28_YEAST", "id": "P23394-1", "name": "Pre-mRNA-splicing ATP-dependent RNA helicase PRP28", "aln": "--------------------------------------------------------------------------MARPID------------------------VSQLIAGINKKK--------------------------GLDENTSGKIS------KPRFLNKQERS------KQERLKENEESLTP-----------------------------------------------------TQSDSAKVEIKKVNSRDDSFFNETN------DKKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTR-AIDLLWKG---------------------------------------KTPKNAAESSYMGKHWTEKSLHEMNERDWRILKEDYAIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVASTGSGKTLAFVIPILIKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQKVTKIWSKESNYDCKVISIVGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVETLVLDEADKMIDLGFEDQVTNILTKVDIN-----ADSAVN---------------RQTLMFTATMTPVIEKIAAGYMQKPVYATIGVETGSEPLIQQVVEYADNDEDKFKKLKPIVAKYDPPIIIFINYKQTADWLAEKFQKETNMKVTILHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRAANEGTAVSFVSAAEDESLIRELYKYVRKH-----DPLNSNIFSEAVKNKYNVGKQLSNEIIY-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * :.: .* .*:* * ** **.* :* :*:.::... ..:. : : :.:...: : .*:*. : *. ** *.*: .*** .*: : . * :::: :* * :: :. : .:**::*. .**.:*****::*** :. *** : **:*.*:: .: : :*:: : .****** :** * **::***.****** **:**:* : * . :** *:*:******.***::** *. : . :.: ::** * *: .* * **:*::******** ***: **:.: :******:***:*** :* :** : :. ::.* : ***:******.*.:*::* *:::*. . ** . :* * .:.:.: * : : ***:***:* *: .* **: ::* : ***.*.*****.:* :::. :*::**:**.**:** :**:*:*::::*.::** *********.: * *::*:: :*.::: :* : : * * . * : *: :* *: ", "identical_positions": 205, "similar_positions": 192, "identity": "24.15%" }, { "cls_id": "homologset.agr.HGNC:17348", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q922U1-1", "uniprot_id": "PRPF3_MOUSE", "id": "Q922U1-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp3", "aln": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTHRMPTLKANIRAVKREQFKQQ--LKEKP----SEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKRE--DYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLG-TEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLS-NPAKKFKIEANAGQLYLTGVVVLHKDVN--VVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6GK69-1", "uniprot_id": "A0A8I6GK69_RAT", "id": "A0A8I6GK69-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp3", "aln": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTHRMPTLKANIRAVKREQFKQQ--LKEKP----SEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKRE--DYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLG-TEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLS-NPAKKFKIEANAGQLYLTGVVVLHKDVN--VVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O43395-1", "uniprot_id": "PRPF3_HUMAN", "id": "O43395-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp3", "aln": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQ--LKEKP----SEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKRE--DYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLG-TEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLS-NPAKKFKIEANAGQLYLTGVVVLHKDVN--VVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VW52-1", "uniprot_id": "Q9VW52_DROME", "id": "Q9VW52-1", "name": "", "aln": "--------------------------MSSIIT------------RKDGDDQK----------LSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNG--------GGGEKKEEVA------------------VPASLSSTQIKLMMAHAQREIEERKRALSNLRDKDPLLASVPSIG---MPVALATQ-ALAKKPTPEDSEKARKIAELQAQIRAKLTG--------NLASLIQPTAVAAAA-AAAAQAQERPKPLILDDEGRTVDKSGRTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPD-DVPAMEWWDSVILTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRRQNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLG-SEAVQDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDCC--VVVVEGGPKQQKKYRRLMLTRIKWEED--NAKGNDGQD-------VPNSCVLVWEGTSQRRHFGEIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTDQQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03338-1", "uniprot_id": "PRP3_YEAST", "id": "Q03338-1", "name": "U4/U6 small nuclear ribonucleoprotein PRP3", "aln": "------------------------------------------------------------------------------------------------------------------------------------------------MPPRNTYEKGNPKRQNSPYYKPSFLRREETTND----------EEKFQGHGLKTELHSALKSSNLNLIRRTYQTG--------ENPYLSDPHDRGSSS--RFNRRYERGLKFYQKGEISKRIAQERTLQKQQEEEELKRKLKQEEDEKDKRK--LIESG------DLPNLELHEDKFLLDLS-KFKIYYDNNHGYEWWDTAYLDEKGELMEKYDMNGTSPAEEK--------------------------------LAEDIDEVDDDDDDE-------HPSIRYVAHPLPEKINEAKVSIKAYLTQHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAWEKVVKDQVDLRKRKHLEENERRHEDAIKRR-KEAVNMNVEKPTVYHCKVFQFKNLQ-NPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMD----MHNNSISKTWEGYLQDCKFKGWFMKVCNDQDSLLRTLGQFDSEHFYSPVQT-----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : *: * .: : ..* * ::*: :: : : * : . :. : : : . : . : :: ** ::: : * ::: * * : .: :. : : : : :. :: . * . :*: : : :. *.:. :.:.:: .:: :.: :: * * : .:**::*:*:***: *: * : : *::*** . ****:::**:* *: : : *** * *: *: *:: * : * *: : :: *: ::. : . * .*::.::*. * :**:: *: :* :.* : :* :::* *. * * :..*:: ****:*: .. .. . *. .*** : * :* :. . : :. **::. . : ", "identical_positions": 77, "similar_positions": 156, "identity": "11.03%" }, { "cls_id": "homologset.agr.HGNC:17349", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A7J8-1", "uniprot_id": "D4A7J8_RAT", "id": "D4A7J8-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "aln": "------------------------------MASSRASST-TTKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKS-KEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKS-LRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSG-LCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHT----VRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFEPIHG-DFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9DAW6-1", "uniprot_id": "PRP4_MOUSE", "id": "Q9DAW6-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "aln": "------------------------------MASSRASST-TTKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKS-KEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKS-LRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSG-LCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHT----VRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFEPIHG-DFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43172-1", "uniprot_id": "PRP4_HUMAN", "id": "O43172-1", "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "aln": "------------------------------MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKS-KEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKS-LRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSG-LCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHT----VRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFEPIHG-NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VVI0-1", "uniprot_id": "Q9VVI0_DROME", "id": "Q9VVI0-1", "name": "", "aln": "MSDDDDIQYIKRQRTLHYGSLEESERKRQNAAASGAAATTTSGTTASSGAGTTTTGTGGQLEDIDSDEDYEESTKKTSNAK-QAGAPPPTAATLANKIDDDYFDLEMEMERDKVALLEEFERKKRARQINVSTDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKK-LQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSG-LCKLWSVPDCELKQTLRGHASYVGGVALRPG-VKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMP---HRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQ--PVYTIPAHTNLISDVKYQQECG-SFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P20053-1", "uniprot_id": "PRP4_YEAST", "id": "P20053-1", "name": "U4/U6 small nuclear ribonucleoprotein PRP4", "aln": "----------------------------------------------------------------------------MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKIPE-----------EDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMEN-INGEEVDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPD-------SNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . .. :: . :* :: . :* *:: * * :* .*. :** ** ::* : : : :: :. *: : :: ....* .** :: :*** *: .** . : .: : . . . : .* **: . :*:* :* :. :: *..*:* * * * . * :.* .* :*.: :* . : * . ** :* : ..:* : *. *:: * :****:*:.::.:* :***** . : *:* **** *. :::: ***: :**:*::. :**:*:* :* * ** :: : :****:::***. *. ::**:*:* : * ** *::: *::. * . *:: .**. :::: * : :* ** .*::.:**: :.: :.: .:**::*** ", "identical_positions": 113, "similar_positions": 157, "identity": "20.07%" }, { "cls_id": "homologset.agr.HGNC:1735", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63692-1", "uniprot_id": "CDC37_RAT", "id": "Q63692-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "-MVDYSVWDHIEVSDD-EDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKEL-EVAEGGGQVELERLRAEAQQLRK----------------EERSWEQKLEDMRKKEKN------------------------MPWNVDTLSKD------------GFSKSMVNTKPE------KAEED--SEEAREQKHKTFVE---------------KYEKQIKHFG--MLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPR------ACFRQFFTKIKTADQQYMEG--FKYELEAFKERVRGRAKLRIEKAMKEYEEE--------------------ERKKRLGPGGLDPVEVYES-LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW-----VPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDISA----------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61081-1", "uniprot_id": "CDC37_MOUSE", "id": "Q61081-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "-MVDYSVWDHIEVSDD-EDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKEL-EVAESDGQVELERLRAEAQQLRK----------------EERSWEQKLEDMRKKEKN------------------------MPWNVDTLSKD------------GFSKSMVNTKPE------KAEED--SEEAREQKHKTFVE---------------KYEKQIKHFG--MLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPR------ACFRQFFTKIKTADHQYMEG--FKYELEAFKERVRGRAKLRIEKAMKEYEEE--------------------ERKKRLGPGGLDPVEVYES-LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW-----VPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA----------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q16543-1", "uniprot_id": "CDC37_HUMAN", "id": "Q16543-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "-MVDYSVWDHIEVSDD-EDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKEL-EVAEG-GKAELERLQAEAQQLRK----------------EERSWEQKLEEMRKKEKS------------------------MPWNVDTLSKD------------GFSKSMVNTKPE------KTEED--SEEVREQKHKTFVE---------------KYEKQIKHFG--MLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPR------ACFRQFFTKIKTADRQYMEG--FNDELEAFKERVRGRAKLRIEKAMKEYEEE--------------------ERKKRLGPGGLDPVEVYES-LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW-----VPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24276-1", "uniprot_id": "CDC37_DROME", "id": "Q24276-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "-MVDYSKWKNIEISDD-EDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERISKK-DGDEEALKKELEKIEAEGKELDR----------------IES-------EMIKKEKK------------------------TPWNVDTISKP------------GFEKTVINKKAG------RKPDENLSEEEREQRMKQFVK---------------ENEKLCQQYG--MLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDVDPR------ACVSSFFSKIQHCHPEYRAQ--FDSEIEGFKGRIQKRAQEKIQEAIAQAEEE--------------------ERKERLGPGGLDPADVFES-LPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLW-----VPNAADLEGDKKEEDDSDD-VAGGEEKTDDAKSESAAKEEPIYTGVSTEDVD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P06101-1", "uniprot_id": "CDC37_YEAST", "id": "P06101-1", "name": "Hsp90 co-chaperone Cdc37", "aln": "MAIDYSKWDKIELSDDSDVEVHPNVDKKSFIKWKQQSIHEQRFKRNQDIKNLETQVDMYSHLNKRVDRILSNLPESSLTDLPAVTKFLNANFDKMEKSKGENVDPEIATYNEMVEDLFEQLAKDLDKEGKDSKSPSLIRDAILKHRAKIDSVTVEAKKKLDELYKEKNAHISSEDIHTGFDSSFMNKQKGGAKPLEATPSEALSSAAESNILNKLAKSSVPQTFIDFKDDPMKLAKETEEFGKISINEYSKSQKFLLEHLPIISEQQKDALMMKAFEYQLHGDDKMTLQVIHQSELMAYIKEIYDMKKIPYLNPMELSNVINMFFEKVIFNKDKPMGKESFLRSVQEKFLHIQKRSKILQQEEMDESNAEGVETIQLKSLDDSTELEVNLPDFNSKDPEEMKKVKVFKTLIPEKMQEAIMTKNLDNINKVFEDIPIEEAEKLLEVFNDIDIIGIKAILENEKDFQSLKDQYEQDHEDATMENLSLNDRDGGGDNHEEVKHTADTVD---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :*** *.:**:*** : :.***:*. *:::*::*: *: : ::: .:*. . .. :.: : : :.*: .:: : * :: *: *. ::* : * **..:.:*.: .: *. ..: : :.: : * :.:* :..:..*:::* ::: :: *: : *:: .:: ::. . : :* ** * :* *: . .: . ** *: . : * .:: ::: *:: :: : : : * : .* :. ..*::: :*:::: .: :::: ::..: : *: :: * .: : * :. : : : . .: .. . ", "identical_positions": 52, "similar_positions": 158, "identity": "10.22%" }, { "cls_id": "homologset.agr.HGNC:17350", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9DC48-1", "uniprot_id": "PRP17_MOUSE", "id": "Q9DC48-1", "name": "Pre-mRNA-processing factor 17", "aln": "MSAAIAALAASYGSGSGSESDSDSEGSRCPLPAADSLMHLTKSPSAKLSLTVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSSVPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIG-AVWHPHETSKVITCGWDGLIKLWD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O60508-1", "uniprot_id": "PRP17_HUMAN", "id": "O60508-1", "name": "Pre-mRNA-processing factor 17", "aln": "MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIG-AVWHPHETSKVITCGWDGLIKLWD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VD52-1", "uniprot_id": "Q9VD52_DROME", "id": "Q9VD52-1", "name": "Pre-mRNA-processing factor 17", "aln": "MLGLQSYASSSDEESDHADAATATTNSEPSAPIPDHLLPVDKTHS--LSKSIAVCAAPTVVPLGASAVPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRRTFHTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEP-PKAKKLRKQEKNDNPEDIEGFLGPWGKFENEVSVAKPNEQERAELDELLSKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPHDLGVNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFVAGTSDKKIICWDTRSGD---IVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIADPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCIS-ALWHPHEASKVVTAGWDGQIKYWD", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P40968-1", "uniprot_id": "PRP17_YEAST", "id": "P40968-1", "name": "Pre-mRNA-processing factor 17", "aln": "-----------------------------------------------------------------------------------------------------------MGLVDGYDTSSDS-DLNFDEGKSVHEKK-------NGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKG---------DGPWGSWSSSDDE--TSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN--PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : ** :. : *:: : .. . .: . .: . :. . :. . . : : ** :* *.*.. :* .::..* :: : * : : . *: ** : :: *. *****.**: *:*:.*:**. . :*:*** *: :.** :* :::: :* :.**:** . * :*:*:.* : .*:* * ** :.:: : :. .***:::** :*:**:***. :*: .. * *: .* : : *:.* *:.**: :* * .: :** **:**.:: :: :. :. :*:::*:**::*:** :* * :* *::.: **** :.: *. :::..**:**:* *. ::: : ** *.** :**. .: ** * *: ***...: ***:*::: .. : . * . ***:*:***: .* * * *", "identical_positions": 129, "similar_positions": 172, "identity": "22.13%" }, { "cls_id": "homologset.agr.HGNC:17351", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JKB8-1", "uniprot_id": "PRP18_RAT", "id": "Q9JKB8-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKVQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPMRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNSREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQ-REYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFS-KHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99633-1", "uniprot_id": "PRP18_HUMAN", "id": "Q99633-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQ-REYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFS-KHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8BM39-1", "uniprot_id": "PRP18_MOUSE", "id": "Q8BM39-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDILKSEILRKRQLVEDRNLLVENKKYFKRSELARKEEEAYYERCGYKIQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQ-REYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFS-KHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6GMH0-1", "uniprot_id": "PRP18_DANRE", "id": "Q6GMH0-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDILKAEIARKRKLIEEKELIDDSKKYFKRAELARKEEEDYYRRCGYKMDKPEEEAPQSTSANPVLELELTEEKLPMTLSRQEVIRRLRERGEPIRLFGESDYDAFQRLRKIEILAPEVNKGLRNDLKAAMDKIDQQYLNEIVGGAEGAELDTQHDLKVHEENTTIEELEALGASLGNGNDVRDMDIINKVLRFLLGVWAKDLNSREDHIKRSVQGKLASATQKQTESYLEPLFRKLRKKNLPADIKESITDIIKFMLE-REYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFS-KHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V437-1", "uniprot_id": "Q9V437_DROME", "id": "Q9V437-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDILKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYIKQESVEAQGQTTEG----AYSFVADGQ-NILPRTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEANRGFRNDFQEAMEQVDAAYLQEMFANTPTTKEDKKSDFAELDESVSWESIQTMAANMGRNKDY-DMDVIITLLTFLLKLWNDQIANYSKHEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPEDILDSLRDICKHLLN-RNYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFS-KNVAHVMNDETQRKYIQGLKRLMTKCQEYFPTDPSKCVEYVSKKDRE", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P33411-1", "uniprot_id": "PRP18_YEAST", "id": "P33411-1", "name": "Pre-mRNA-splicing factor 18", "aln": "MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEE------------------------------------------------------------NLSDNQSDDIRTTISKLENR------------PERIQEAIAQDKTISVIIDPSQIGSTEGK-----------PLLSMKCNLYIHEILSR----WKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA----------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: :.* : . :.::* .. : . . . : : . . :*:: ::.::: : : . . . :. . *. .* : :: .:: : :*:. : **: :*::. *. *: *: : .: : :: * ::*::::***..****** ******:.:.** . ::.*::: ** * :* .:***:* : : ... * . ", "identical_positions": 43, "similar_positions": 92, "identity": "12.36%" }, { "cls_id": "homologset.agr.HGNC:17352", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60705-1", "uniprot_id": "ABEC3_RAT", "id": "P60705-1", "name": "DNA dC->dU-editing enzyme APOBEC3", "aln": "-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVSLHHGVFK----NKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELS---QVIITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99J72-1", "uniprot_id": "ABEC3_MOUSE", "id": "Q99J72-1", "name": "DNA dC->dU-editing enzyme APOBEC-3", "aln": "MQPQRLGPRAGMGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFK----NKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELS---QVTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UH17-1", "uniprot_id": "ABC3B_HUMAN", "id": "Q9UH17-1", "name": "DNA dC->dU-editing enzyme APOBEC-3B", "aln": "-----------MNPQIRNPMER---------MYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCG---NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILR--YLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGT-----WVLMDQHMGFLCN------------EAKN--------LLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDP-LYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN-----------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.* . .* : ::** :*:* .*. *:*****. * * : . ***: * : ***:*** ** . : *.. : *:***::**:** :*. :: .**: * *::* * ::*** : : :: **** * **:*: ** ** **::** * *::* ** :: *: : . .*:**** *: *.: : .:.* *. :* : * .*:. : : :*:: .** * * **. :***: *** : *::*. :* :::**** .** :: ** ::...: *:*:::*:* : :::.* * ::* *.:* :* ** .** : ** **.*** *: . **: * :. * ", "identical_positions": 131, "similar_positions": 115, "identity": "29.11%" }, { "cls_id": "homologset.agr.HGNC:17354", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60705-1", "uniprot_id": "ABEC3_RAT", "id": "P60705-1", "name": "DNA dC->dU-editing enzyme APOBEC3", "aln": "-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVSLHHGVFKN----------------KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILR-PCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELSQVIITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99J72-1", "uniprot_id": "ABEC3_MOUSE", "id": "Q99J72-1", "name": "DNA dC->dU-editing enzyme APOBEC-3", "aln": "MQPQRLGPRAGMGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----------------KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILR-PCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELSQVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96AK3-1", "uniprot_id": "ABC3D_HUMAN", "id": "Q96AK3-1", "name": "DNA dC->dU-editing enzyme APOBEC-3D", "aln": "-----------MNPQIRNPMER---------MYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCG---NRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPN----------------------------TNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ---------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.* . .* : ::** :*:* .*. *:*****. * * : . ***:. : : ***:*** ** . : *.....*:***::**.**: *. :: :*** * *::* * ::*** :* : : * ** : **:* ** :* **::** * *: * ** :: *: . .*:**** * * :.*: : * *: : . . . * .:.::*. : * : :*.: ::: . :: :* * :*****:** ::* * :.:: * *:*:** :.*. :*:***** *.* *.:*. :*..**.*** .. .** *****: * :***:.* : ", "identical_positions": 126, "similar_positions": 112, "identity": "27.51%" }, { "cls_id": "homologset.agr.HGNC:17356", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60705-1", "uniprot_id": "ABEC3_RAT", "id": "P60705-1", "name": "DNA dC->dU-editing enzyme APOBEC3", "aln": "-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSP---VSLHHGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILR-PCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELSQVIITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVN-PKRPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99J72-1", "uniprot_id": "ABEC3_MOUSE", "id": "Q99J72-1", "name": "DNA dC->dU-editing enzyme APOBEC-3", "aln": "MQPQRLGPRAGMGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSP---VSLHHGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILR-PCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELSQVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVN-PKRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IUX4-1", "uniprot_id": "ABC3F_HUMAN", "id": "Q8IUX4-1", "name": "DNA dC->dU-editing enzyme APOBEC-3F", "aln": "--------------------MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEHHAEMCFLSWFCG---NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPN----------------------------TNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE---------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : ::**.::* * *: .:*****. *. . * ..:.:* . .: : ***:*** ** . : *.. : *:***::**:** :*. :: .*** * *::* * ::*** : : :: **** * **:* ** ** **::** . *: * ** :: *: : . .*:**** * * :.*: : * *: : . . :. * .: .:.::*. : * : :*.: ::: . :: :* * :*****:** ::* * :.:: * *:*:***:.*. :*:** ** *.* *::*. :*. ** *** ..** *****: : :*:.* * ", "identical_positions": 119, "similar_positions": 117, "identity": "26.74%" }, { "cls_id": "homologset.agr.HGNC:17357", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60705-1", "uniprot_id": "ABEC3_RAT", "id": "P60705-1", "name": "DNA dC->dU-editing enzyme APOBEC3", "aln": "-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSP---VSLHHGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEG----AQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELS---QVIITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99J72-1", "uniprot_id": "ABEC3_MOUSE", "id": "Q99J72-1", "name": "DNA dC->dU-editing enzyme APOBEC-3", "aln": "MQPQRLGPRAGMGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSP---VSLHHGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEG----AQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSMELS---QVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPK-RPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HC16-1", "uniprot_id": "ABC3G_HUMAN", "id": "Q9HC16-1", "name": "DNA dC->dU-editing enzyme APOBEC-3G", "aln": "--------------------MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFS--KWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILR--HSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDT-----WVLLNQRRGFLCN-----------------QAPHKHGFLEG---RHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGR-CQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN-----------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : : : ::**.::* * *: .:*****. *. . * ..:.:* . .: : *.*: *::** : * :*:::***:***** :*:.:: *** . :::* ** :*** . **: *: * * *: * : *: **::**.*** . . *.**:.* . : . * **** : *.: : .:.* .:* ** : * .*:. : : *** .** *** * :*. :***: *** * :*. : :**: :**** .** ::* * .. .: * *:*:*:* . * *:** :* ::* :.:* .:*..** .**: : ** **.**: *: . **: * :. ", "identical_positions": 124, "similar_positions": 119, "identity": "27.49%" }, { "cls_id": "homologset.agr.HGNC:17358", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "B5DEJ6-1", "uniprot_id": "B5DEJ6_RAT", "id": "B5DEJ6-1", "name": "Thiamine pyrophosphokinase", "aln": "--------------------MEHVFTPLEPLLPTGDLKFCLVVLNQTLDP---HFRHLWRKALLRACADGGANHLYDLTEGE---RESFLPEFINGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCLQVLQRKIEE--------------------------------------KELQVDVIVTLGGLGGRFDQIMASVNTLFQATD-IIPVPIIIIQKESLIYLLQPG-KHRLRVDTGMEG---SWCGLIPVGQPCNHVTTTGLKWNLTNDVLGFGT-LVSTSNTYDGSG------LVTVETDHPLLWTMAIKT--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R0M5-1", "uniprot_id": "TPK1_MOUSE", "id": "Q9R0M5-1", "name": "Thiamine pyrophosphokinase 1", "aln": "--------------------MEHAFTPLEPLLPTGNLKYCLVVLNQPLDA---RFRHLWKKALLRACADGGANHLYDLTEGE---RESFLPEFVSGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCLQVLQRKIEE--------------------------------------KELQVDVIVTLGGLGGRFDQIMASVNTLFQATH-ITPVPIIIIQKDSLIYLLQPG-KHRLHVDTGMEG---SWCGLIPVGQPCNQVTTTGLKWNLTNDVLGFGT-LVSTSNTYDGSG------LVTVETDHPLLWTMAIKS--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3S4-1", "uniprot_id": "TPK1_HUMAN", "id": "Q9H3S4-1", "name": "Thiamine pyrophosphokinase 1", "aln": "--------------------MEHAFTPLEPLLSTGNLKYCLVILNQPLDN---YFRHLWNKALLRACADGGANRLYDITEGE---RESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEE--------------------------------------KDLKVDVIVTLGGLAGRFDQIMASVNTLFQATH-ITPFPIIIIQEESLIYLLQPG-KHRLHVDTGMEG---DWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGT-LVSTSNTYDGSG------VVTVETDHPLLWTMAIKS--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1RBJ9-1", "uniprot_id": "F1RBJ9_DANRE", "id": "F1RBJ9-1", "name": "Thiamine pyrophosphokinase", "aln": "---------------------MDEFTPLDCLLPSGKQRICLVILNQPLDER--YFHVLWSKAQIRACADGGANHLYRLTEGR---RESFLPDYINGDFDSILPEVKAFYAGKNCKLMETPDQDLTDFTKCLAIMLEEIKA--------------------------------------KKLQIDSIVTLGGLGGRFDQTMATVETLFHAQK-MTDLPVVVIQDSSLAFLLKEGRHHQLNVNTGMEG---KWCSLVPVGSPC-LTTTSGLKWNLDNQVLAFGQ-LVSTSNTYEDHDPKDCRKPVTITTDNPLLWSMGIKRLQSSQTFL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P35202-1", "uniprot_id": "THI80_YEAST", "id": "P35202-1", "name": "Thiamine pyrophosphokinase", "aln": "MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKN-GTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDN------CCFIDTKDDIILNVEIFVDKLIDFL-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :. : : .. . . *::*** :* * :* ::.****.**:** :. * .:**::: **:**: :* :* : ::. . * ******: :: .:: ..: :::***:.***** : :: *: . . : : .* :*:: . :. :. :.. *.*:*:*.. * ****:: * .. **:** : . . : *.. :: .: * ", "identical_positions": 58, "similar_positions": 88, "identity": "17.74%" }, { "cls_id": "homologset.agr.HGNC:17359", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BTS4-1", "uniprot_id": "NUP54_MOUSE", "id": "Q8BTS4-1", "name": "Nuclear pore complex protein Nup54", "aln": "-MAFN-------------------FGAPSG--------------------TSGTSTATAAP-----------------------------------------------------------------------AGGFGG--FG-------TTTTTAG-----SAFS-FSAPTNTGSTGLLGGTQNKG-----FGFGTGFGTTTGTGT---GLGTGLGTGLGFGGFNTQQQQQQQQTSLGGLFSQPT----------------------QAPAQSTQLINTASALSAPTLLGDER--DAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPNNKDE--DGLVVLIFNKKETDIRSQQQQLVESLHKVLGGNQTLTVNVEGIKTLPDDQTEVVIYVVERSPNGT--SRRVPATTLYAHFEQANIKAQLQQLGVTLSMTRTELSPA-QIKQLLQNPPAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQ-KNQTTTMAKIAQYKRKLMELSHRTLQVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGR--LNELMSQIRMQNHFGAVKSEEKYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNETIHSRGGVFS------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P70582-1", "uniprot_id": "NUP54_RAT", "id": "P70582-1", "name": "Nuclear pore complex protein Nup54", "aln": "-MAFN-------------------FGAPSG--------------------TSGTSTATAAP-----------------------------------------------------------------------AGGFGG--FG-------TTTTTAG-----SAFS-FSAPTNTGSTGLLGGTQNKG-----FGFGTGFGTSTGTGT---GLGTGLGTGLGFGGFNTQQQQQQQQTSLGGLFSQPA----------------------QAPAQSNQLINTASALSAPTLLGDER--DAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPNNKDE--DGLVVLIFNKKETDIRSQQQQLVESLHKVLGGNQTLTVNVEGIKTLPDDQTEVVIYIVERSPNGT--SRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPA-QIKQLLQNPPAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQ-KNQTTTMAKIAQYKRKLMDLSHRTLQVLIKQEIQRKSGYAIQAEEEQLRVQLDTIQGELNAPTQFKGR--LNELMSQIRMQNHFGAVKSEEKYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNETIHSRGGVFS------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7Z3B4-1", "uniprot_id": "NUP54_HUMAN", "id": "Q7Z3B4-1", "name": "Nucleoporin p54", "aln": "-MAFN-------------------FGAPSG--------------------TSGTAAATAAP-----------------------------------------------------------------------AGGFGG--FG-------TTSTTAG-----SAFS-FSAPTNTGTTGLFGGTQNKG-----FGFGTGFGTTTGTST---GLGTGLGTGLGFGGFNTQQQQ---QTTLGGLFSQPT----------------------QAPTQSNQLINTASALSAPTLLGDER--DAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPSNKDE--DGLVVLVFNKKETEIRSQQQQLVESLHKVLGGNQTLTVNVEGTKTLPDDQTEVVIYVVERSPNGT--SRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPA-QIKQLLQNPPAGVDPIIWEQAKVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQ-KNQTTSVAKIAQYKRKLMDLSHRTLQVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGR--LNELMSQIRMQNHFGAVRSEERYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNETIHIRGGVFS------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9PCH0-1", "uniprot_id": "A0A8M9PCH0_DANRE", "id": "A0A8M9PCH0-1", "name": "54 kDa nucleoporin", "aln": "-MAFN-------------------FGGASGSASAPGFSFKSSSSTPFGFGASTTTTASSATGFGLTGTGFGAPTTTSASTGFGFGTGGTGFGPLVCSAGPGPAPSAAAVSFGGFGLGPAAPVFSFGSGLGGAAGAFGG--FG-------STTTSAGT---GSSFS-FSTPANTGSS-LFN-TQSKG-----FGFSSAPAPASGFTG---ALG---GGALGFGGFGALQNTQQ-----GGVFGQ------------------------QAPPPCSQLFNTASALSAPAVLSDER--DSILARWNQLQAFWGIGRGYYCSTTPPVEFSQENPFCRFKAVGYSCVPDVRDE--DGLLALALGKREADVRLQQQQLVESLHKLLGGAHTLSVNVEGVRALPDDQTEVIIYVVERSPNGS--SKRVPASTLYNFLEQVNIKTQLQQLSVIMTVSRTALSPA-QLKQLLQNPPAGVDPIIWEQAKVDNPDPEKLIPVPMVGFRELLRRLKIQEQMTKQHQTRVDIISTDISELQ-RNQATTAAKITQYKRKLMDLSHRVLQVLIRQEVQRKSGYAVQLDEEHLRVQLETIQSELNAPTQFKGR--LNELMSQIRMQNHFGAVRAEERYRVDADLLREIRQHLKHQQEGLSHLISVIKDDLDDIKTIEDGLHDSVHTRSSKLS------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V6B9-1", "uniprot_id": "NUP54_DROME", "id": "Q9V6B9-1", "name": "Probable nucleoporin Nup54", "aln": "-MSFFGSNTSLGATSTPAKTTGGLFGSPFGGTAATSQPAPAFGAQATSTPAFGAQPATSAFGAGSAFGATAAAPAFGAATG---------------------------------------------------TSAFGGSAFGSTPAFGAATTTTAGTGLGGGGFGGFGAAPATSQAGLFGAPATSAAPPAFSGFGQQAAASTAPASGFSGFGTTTTSAPAFGGFGTSQSTGFGGGAFGSTFGKPANTTVTPGFGGFGGTSFMLGQPQQQPAPISADEAFAQSILNVSIFGDER--DKIVAKWNYLQATWGTGKMFYSQSAAPVDITPENVMCRFKAIGYSRMPGKDNK--LGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNMLVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRILATELSNYLNQATLKPQLNNLGVVEALALVLPDED-QLREYLENPPRGVDPRMWRQANSDNPDPTLYIPVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELK-KRHATATAKILEHKRKLAELSHRILRIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFKGR--LSELLSQMRMQRNQFAANGGAEYALDKEAEDEMKTFLTMQQRAMEVLSDTVNKDLRALDVIIKGLPELRQS------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P48837-1", "uniprot_id": "NUP57_YEAST", "id": "P48837-1", "name": "Nucleoporin NUP57", "aln": "MFGFSGSNNG--------------FGNKPAGSTG---------------FSFGQNNNNTNT-----------------------------------------------------------------------QPSASGFGFG-------GSQPNSGT----ATTGGFGANQATNTFGSNQQSSTGG-----GLFGNKPALGSLGSS---STTASGTTATGTGLFGQQTAQPQQSTIGGGLFGNKP---------------------TTTTGGLFGNSAQNNSTTSGGLFGNKVGSTGSLMGGNSTQNTSNMNAGGLFGAKPQNTTATTGGLFGSKPQGSTTNGGLFGSGTQNNNTLGGGGLFGQSQQPQTNTAPGLGNTVSTQPSFAWSKPSTGSNLQQQQQQQIQVPLQQTQAIAQQQQLSNYPQQIQEQVLKCKESWDPNTTKTKLRAFVYNKVNETEAILYTKPGHVLQEEWDQAMEKKPSPQ-TIPIQIYGFEGLNQRNQVQTENVAQARIILNHILEKSTQLQQKHELDTASRILKAQSRNVEIEKRILKLGTQLATLKNRGLPLGIAEEKMWSQFQTLLQRSEDPAGLGKTNELWARLAILKERAKNISSQLDSKLMVFNDDTKNQDSMSKGTGEESNDRINKIVEILTNQQRGITYLNEVLEKDAAIVKKYKNKT", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.* ** . : .: . .* ** : ..:* . . *.: *. . . . *. . : . . . * *. *. *.: . .: ::.:: : * * . . . : . : *. * : . .. . .* : * : * . .. .: . :.: : * : : :. .::: : . * . : . : . : . * . * * * ** .:*.. **: : **. * * : * : . :. : . ::*: :.. : ::* : : : ::.:* *:: : :: * .: ** : :::.: . *: : * :: :: : : : . . : : : . . . . : . * . * : . ", "identical_positions": 48, "similar_positions": 149, "identity": "7.04%" }, { "cls_id": "homologset.agr.HGNC:1736", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P60953-2", "uniprot_id": "CDC42_HUMAN", "id": "P60953-2", "name": "Cell division control protein 42 homolog", "aln": "MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8CFN2-1", "uniprot_id": "CDC42_RAT", "id": "Q8CFN2-1", "name": "Cell division control protein 42 homolog", "aln": "MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P60766-2", "uniprot_id": "CDC42_MOUSE", "id": "P60766-2", "name": "Cell division control protein 42 homolog", "aln": "MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P40793-1", "uniprot_id": "CDC42_DROME", "id": "P40793-1", "name": "Cdc42 homolog", "aln": "MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDENSTLEKLAKNKQKPITMEQGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPTKKRKCKFL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P19073-1", "uniprot_id": "CDC42_YEAST", "id": "P19073-1", "name": "Cell division control protein 42", "aln": "MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLRDDKVIIEKLQRQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPPVIKKSKKCAIL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "***:**********************:**::****************.*************************.**********:**.*********.**: *** .* *:*********: :*** ::: :*** * ..:**::**************:**********:****** .*.::* :*", "identical_positions": 147, "similar_positions": 30, "identity": "76.96%" }, { "cls_id": "homologset.agr.HGNC:17360", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0RB60-1", "uniprot_id": "M0RB60_RAT", "id": "M0RB60-1", "name": "", "aln": "---------------------------------------------------------------------------------------------------------------------------------MARPGPGVFGAPRLAPRLLLWLLLLLLL--------------------------------------------------------------------------------------LLQGPESAVAQAGPR----APCAAACTCAGDSLDCSGRGLATLPRDMPSWTRSLNLSYNRLSEIDPAAFEDLTNLQEVYLNSNELTAVPSLGAASMHVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRVRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFK-LPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLKLQRNNLSKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSGLSILRLSHNAISHIAEGAFKGLKSLRVLELDHNEISGTIEDTSG--AFMGLDNLSKLTLFGNKIKSVAKRAFSGLENLEHLNLGENAIRSIQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLVSRMLQAFVTATCAHPESLKGQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSS------PMTFAWKKDNEVLTN------ADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKVDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGS------PTPRITWLKGGRPLSLT------ERHHFTPGNQLLVVQNVEAEDAGRYTCEMSNPLGTERAHSQLSILPTPGCRKDGSTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCLRDPSLFPEVDVHSFACRQPKLCVG--YTREPWKVTEKADRTTAPHPTAHSGSAVCSDCRSDTASQPQEQAFHPQTVPRDSGQPGTSSSQELRQHDRECSPHHPYSGTVDGPHALSGGSLYPSNHDRILPSLRNK-AACADGKGDSSWTLAKLQEADCIDLKPS-----GSPELMEDAISTEAQHLLVSNGQLPKACDSNPDSVPLKGQVTGRRRGPLLLAPKS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P70193-1", "uniprot_id": "LRIG1_MOUSE", "id": "P70193-1", "name": "Leucine-rich repeats and immunoglobulin-like domains protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------MARPGPGVLGAPRLAPRLLLWLLLLLL-----------------------------------------------------------------------------------------QWPESAGAQAGPR----APCAAACTCAGDSLDCSGRGLATLPRDLPSWTRSLNLSYNRLSEIDSAAFEDLTNLQEVYLNSNELTAIPSLGAASIGVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRIRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFK-LPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISRLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAFKGLKSLRVLDLDHNEISGTIEDTSG--AFTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLGENAIRSVQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLKGQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSS------PMTFAWKKDNEVLAN------ADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRYQCIITNHFGSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGS------PTPRITWLKGGRPLSLT------ERHHFTPGNQLLVVQNVMIDDAGRYTCEMSNPLGTERAHSQLSILPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGHQANGHIESNGVCLRDPSLFPEVDIHSTTCRQPKLCVG--YTREPWKVTEKADRTAAPHTTAHSGSAVCSDCSTDTA-------YHPQPVPRDSGQPGTASSQELRQHDREYSPHHPYSGTADGSHTLSGGSLYPSNHDRILPSLKNK-AASADGNGDSSWTLAKLHEADCIDLKPSPTLASGSPELMEDAISTEAQHLLVSNGHLPKACDSSPESVPLKGQITGKRRGPLLLAPRS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96JA1-1", "uniprot_id": "LRIG1_HUMAN", "id": "Q96JA1-1", "name": "Leucine-rich repeats and immunoglobulin-like domains protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------MARPVRGGLGAPRRSPCLLLLWLLLLR-------------------------------------------------------------------------------------------LEPVTAAAGPR----APCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG--AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSS------PMTFAWKKDNEVLTN------ADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGN------PPPRITWFKGDRPLSLT------ERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPE------RAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A1ZAB1-1", "uniprot_id": "A1ZAB1_DROME", "id": "A1ZAB1-1", "name": "", "aln": "MHVSAIKGRHPTRESNDDSSMVISNYRICDIKTSGNGKYLMSWSRRRRRNNNNNNNSSSNNNNAASESRSNDNCNYSTTNDFNKINKLLLITYMLLITAATICQSAAQSPSSSNGNGVGGSGSTGGSPLSALLKSGGASYNQQLPQQQLFAMLTRNGGGSSGPRSSGGNRGYTSARQHFMALSEDYSDADVDEEDMAALHYPLSASHPPAGVQGSSSSSGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVP-VLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKFIGLSG-LKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLN-NLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFN-QLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVKEN-LNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLRPRSLADLGCSYDEANHRRLTVMSTPPSEQR---------CLEQGLTLSYLRQTDLEAQQDHLSSK----DSGTGSDAAVKRTLDDFEVAMPSHKHHTDDEEEEE---------VEEVYEENEPPYIKHTYEVNYAEPEQ---HLFLQNNNHNYDGGGIGVAGGVNKMVPNALLRKCSAGASGSNYSSIQQCTTVDI--------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * * . : * * :* *.. * * . *. *.* . :**. * :* :**:.::*:*: *:*.: :.:* ** :* *: * * .:*.: . * : *.* :*:* *:....* : *..**** *:: :. ..**:. : .* *: *.* :: :* *. .* *.**:**:: **::.** * :*.:* ** * *: **:**:*:: *:*: *:: * **.*: : *:..:.* *.: .:. .*:.** *::*:** *:*:**. . *.* *.*. * ** * :..:. : * * *. *.*:** :.:: *.:*. ::.*. *:* :*.:* *** *. .* ** .* :* *.**::*.::.:*:***:.** **** **: *:*.:** :* .*::* :.* .*:***:* *: ** .*: * *.*.:** * .: : *: ...:** * **:: :*: :*: . :* : * *:*.::: :.: *::**: : : . : : . : . *:* :**: *****:::* **:**::* ::::.: *:* : * :::: : *** *:*:*.*.*:** ** **::**** ***::*: :::.*:**:.* .* *:*:*** .:**.:..****.* :.*. :** .: * **.* .:** : *: *:* .:*: :: :*:::: .::***: *. :***:: **::: * :*:* :: . ***:*::*:. :* .::* : **.:* . :. . . : * .:.. .* . ..*: **: * . * * .: :. . .:* :*. . .. * . . :* : : * .:. * * : * * . .: . :. : :: .* * .*.. ** . . ", "identical_positions": 293, "similar_positions": 352, "identity": "21.7%" }, { "cls_id": "homologset.agr.HGNC:17361", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3U108-1", "uniprot_id": "ARI5A_MOUSE", "id": "Q3U108-1", "name": "AT-rich interactive domain-containing protein 5A", "aln": "-------------------------MAAPPAKGNTEQSE------EGDLPQLPVSPKPDDEQSRSQSPTQLQDSPEAGGEQEEEQ------AFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPPTKPRKQYKMAKELRGDDGTTEKLKKAKD--SEERRVEQTTPGKTKSDATGQTQLPCQ--GSSRDSTEQLGPVSGPSPPLTGASSCPEAYKRLLSSFYCKGAHGIMSPLAKKKLLAQVSKAEALQCQEEGCRHGAR---SPNKDIQDSPQNLRGPAENSEHQLTPREGLQAPGGSTRMEAQVGPCPTAPMFSGCFHAYPTEVLKPVSQHP----RDFFSGLKDRVLLGPPGKEEGPTTKESHLVWGGDANHPSAFHKG--STRKRSFYPKPKACWVSPMAKVPTERPGAPSPHPSSPGLGSKRGLEEEGFAHGGKKLRAVSPFLKEVDSKETGGKPAAPGLAVSCLLGPTPGPTPPEAYRGTMLRCPLNFTGSADPLKGQASLPFSPLVIPAFPAHLLATTGSSPMAASLMHFPPTPYDAVLRNRLGPASSAWHMPPVTTYAAPHFFHLNTKL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A0G2K0Q5-1", "uniprot_id": "A0A0G2K0Q5_RAT", "id": "A0A0G2K0Q5-1", "name": "", "aln": "--------------------------MAPSAKGKAEQSE------EGDLQEPPVSPKPQDEQSKSQSPIQLEDSPKAGGEQEEEQ------AFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPPTKPRKQYKMAKELRGDDGATEKLKKAKD--SEERQADQTTSEKTKSDAPGQTQLPRQ--GSSRDSTEQLGPVSGSSPPFLGANSCPEAYKRLLASFYCKGAHGIMSPLAKKKLLAQVSKAEALQCQEEGCRHGAR---SPNKDLQESSQNPRGLAENSEHQLTPPEGLRAPGGSTGVEAQVGPCPTAPTFLGRFHAYPTEVLKPVSQHP----RDFFSSLKDRVLLGPPGKEEGLTAKESQLVWGGDANRPSAFHKG--STRKRSFYPKPKACWVSPMAKVPAESPGAPLPHPRSPGLSKKRGLEEEGYTHGGKKLKAVSPFLKEVDARESEGKPAAPGLAVSCLLGPALGPTPPESYRGTMLRCPLNFTSSADPLKGQASLPFSPLVIPTFPAHLLATTGPSPMATSLMHFPPTPYDTVLRNRLGPASSAWHVPPVTTYAAPHFFHLNTKL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q03989-1", "uniprot_id": "ARI5A_HUMAN", "id": "Q03989-1", "name": "AT-rich interactive domain-containing protein 5A", "aln": "--------------------------MAAPVKGNRKQST------EGDALDPPASPKPAGKQNGIQNPISLEDSPEAGGEREEEQEREEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPTSKPRKQYKMAKENRGDDGATERPKKAK----EERRMDQMMPGKTKADAADPAPLPSQ--EPPRNSTEQQGLASGSSVSFVGASGCPEAYKRLLSSFYCKGTHGIMSPLAKKKLLAQVSKVEALQCQEEGCRHGAEPQASPAVHLPESPQSPKGLTENSRHRLTPQEGLQAPGGSLREEAQAGPCPAAPIFKGCFYTHPTEVLKPVSQHP----RDFFSRLKDGVLLGPPGKE-GLSVKEPQLVWGGDANRPSAFHKG--GSRKGILYPKPKACWVSPMAKVPAESPTLPPTFPSSPGLGSKRSLEEEGAAHSGKRLRAVSPFLKEADAKKCGAKPAGSGL-VSCLLGPALGPVPPEAYRGTMLHCPLNFTGTPGPLKGQAALPFSPLVIPAFPAHFLATAGPSPMAAGLMHFPPTSFDSALRHRLCPASSAWHAPPVTTYAAPHFFHLNTKL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58G603-1", "uniprot_id": "A0AC58G603_DANRE", "id": "A0AC58G603-1", "name": "", "aln": "MPTDPADLLAVRRSCYPLRHRDAGHFRVLDPRGEVDAAEGELEDCEKKNQELNSPNQTNGEMESLTSTNSSEDNSRSDQSESEER------TFITNLYCFMKERNTPIERIPHLGFKQINLWKIYKAVETLGGYDAVTARRQWKNVYDELGGSPGSTSAATCTRRHYERLVLPFERQLRGEEDKPLPPSKPRKQYKRSPENRGSKPESKKKRKMERDESEEKMLSDHHCDRGRCSHHSPWLISSDRLDSEHTSTAPVLGMSSRENPLLQTSSPPEVISPLEKKKRLAQASLTIPASEDGGELERPSVIHISHSSQSNTRGRHS---SDGSPVPVSSPSGSLSRSPSPYSVSSEDCIAVTTQKSPAKEPENKTATRLPALSTSKAVSTGVCKPLSCYPNTKELANYPRLHYREFLQAGATE---KTQRSLLAWTSDDKSRLASHRLPLPAYTKPYWVPHASSFSKVLPRDPCRPMSSLQPSFKPHMSSYHQHLLKRPDEAYLKKMPVSSPIRITDRKEKAKTALPKPLPTQQYLFHPHGGLTVP--YQPALERLRGDLT-----VEQLKALPLQPVLFPTHLSIPPAQSHSMHCPPVGTHFP-GSYEAALPSYNYPMP-IWHAP--AGYNMPSLQPY----", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :*: . : * . : . :. .: . .. . :*...:. ...**: :*:..** *****:*****:******************.**.*: **.** *******************************: *:*:**:*****.:******* : * **.. ::: :* : **: .: : :.. . :. : . : ** *. . .: :.. **. . * . : :.. . * : * . :..:.. * * : *. . . * : ::. : : .. . : . .: . : .* * **:* :* :. *: :* . ..* ..:.. *.* .* : * *: : . : :.: . :.: * . . . . :: * :. *:: . **: .: . . . *: * * . * *: :: : ::* :: :**:.*:::*:. : * : . .. *** .:::.* * . ** * : * * : ", "identical_positions": 148, "similar_positions": 182, "identity": "23.12%" }, { "cls_id": "homologset.agr.HGNC:17362", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BM75-1", "uniprot_id": "ARI5B_MOUSE", "id": "Q8BM75-1", "name": "AT-rich interactive domain-containing protein 5B", "aln": "-----------------------------------MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVR--------------------------------CTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWAHSDFSKWRCGLRATPVKT------------EAFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRS-----MLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENE-SVCDEFAPNLKGRPRKKKT-CPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKN-NHNNCKKTSNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNTQENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDTSE----------------VSSEQRKEEETLN-HKSAPEPLPAPEVKGKPEGHKDLGARAPVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEKDSAPTPGAGKQP-LASPSTQMDSKQEAKPCCFTESPEKDLQGAPFSSFSATKPPLTSQNEAEEEQLPATANYIANCTVKVDQLGSDDIHTALKQTPKVLVVQSFDMF-----KDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIAREDLCSGLSQGHHSQS--SDHTAVSRPSVIQHVQSFKNKASEDRKSINDIFKHDKLS----RSDAHRCGFSKHQLGSLADSYILKQETQEGKDKLLEKRAVSHAHVPSFLADFYSSPHLHSLYRHTEHHLHNEQSSKYAA--RDAYQ-ESENGA-FLSHKHPEKIHVNYLASLHLQDKKVAAAEASTDDQPTDLSLPKNP---HKLTSKVLGLAHSTSGSQEIKGASQFQVVSNQSR--DCHPKACRVSPMTMSGPKKYPESLARS-GKPHQVRLENFR--KMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPA--KEASGKEKASEQESEGNKGAYGG--HSGAASEGHKLPLSTPIFPGLYSGSLCN------SGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAGINPQAAFPSSQLSSVHPSTKL-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AEL5-1", "uniprot_id": "A0A8I6AEL5_RAT", "id": "A0A8I6AEL5-1", "name": "AT-rich interactive domain-containing protein 5B", "aln": "-----------------------------------MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVR--------------------------------CTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWAHSDFSKWRCGLRATPVKT------------EGFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEENNVIVLSYPQYCRYRS-----MLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENE-SVCDEFAPNLKGRPRKKKT-CPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKN-NHNNCKKSSSEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNAQENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDPSE----------------VSSEQRKEEETLS-QKSVPEPLPAPEVKKKPEGHKDLVVRAPVSRADPEKGNETDQGSNCEKEAEEVGDKGLAPLLPSPPLPPEKGSAPTPGAGKQP-LASPSAQMDSKQEAKPCCFPESPENDLQGAPFSSLPTTEQPLAVQPEAEEEKLPAMANYIANCTVKVDQLGSDDIHTALKQTPKVLVVQSFDMF-----KDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDQ----SQAHHSQS--SDHMAISRPSVIQHVQSFKNKASEDRKSINDIFKHDKLS----RSDAHRCGFSKHQLGSLADSYILKQEAQESKDKLLEKRAVSHAHVPSLLADFYSSPHLHSLYRHTEHHLHNEQSAKYAA--RDVYQ-ESENGA-FLSHKHPEKIHVNYLASLHLQDKKLAAAEASTDEQPTDLSLPKNP---HKLTSKVLGLAHSASGSQEIKGTSQFQVISSQSR--DCHPKACRVSPMTMSAPKKYPESLARS-GKPHHVRLENFR--KMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPA--KEASGKEKASEQESEGNKAAYSG--HSGAASEGHKVPLSSPIFPGLYSGSLCN------SGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q14865-1", "uniprot_id": "ARI5B_HUMAN", "id": "Q14865-1", "name": "AT-rich interactive domain-containing protein 5B", "aln": "-----------------------------------MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVR--------------------------------CTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKT------------EALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRS-----MLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENE-SICDEFAPNLKGRPRKKKP-CPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKN-NHN-CKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAE----------------VSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQP-LTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMF-----KDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQS--TDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLS----RSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPS--RDMYR-ESENSS-FPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNP---HKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSR--DCHPKACRVSPMTMSGPKKYPESLSRS-GKPHHVRLENFR--KMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPS--KEVSGKEKASEQESEGSKAAHGG--HSGGGSEGHKLPLSSPIFPGLYSGSLCN------SGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F888-1", "uniprot_id": "ARI5B_DANRE", "id": "E7F888-1", "name": "AT-rich interactive domain-containing protein 5B", "aln": "-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSDLRSWKKGLQAVPLKPG---------VLKELGKNGQREALHKYRESTLNSGLNFKDVLKEKAELGEDADDKKVLVLSYPQYCRYRS-----IIARLRERPSSLLTDHVVLALGGIASLTNSTQILYCRDTFEHPTLVENE-SVCDEFAPNLKGRPRKKKLSISQRRDSQSGGARESNGVEGKTLVKMRADSKSGVSKPRNPSTGSCKRVQSENKPKGDGGDECRTDEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYEVITARRQWKNVYDELGGNPGSTSAATCTRRHYERLILPYERFTKGEEDKPLPPAKPRKQEGSVQESIIKAKMMPIKRPKDEQKTPRGDKDASAKVLELGM----------------EDMEELQE-------KQNSQQLQAPTQTDR-------DPNSPLTEDDEGVLVIKDEDQPVLHNAYEHANGGLLPSLP-------QDGAQLKSEDCDA-FPVAAVPLHHGHP-----LPNSHTSDQWKHGILEYKVPPSALAN---------------VEQSRPKEGQNQVVMVLPTLQQKP----VTSPEIP-----PER-VEPLKKEESCFNFNPLLYPRGNPGIMSPLAKKKMLSQVSGTGLLNNYPYGPPPPLVSRRLSSSGTEVSSAGQSSSQVSSSVETSIVIKRPSVIQHAQSFKSRGSEDRRSSTEGSQKDGCS----EGEP-----VHHSQTLIREPYLKRVDPHSSMEKSAEMPRP--GQAPSFLSEFYSSPHLHNLCRQTEHHLSKEQISKYLS--RDVYTRDSETAQGFPPSQHPDNVGLNFSARLSQKEKG-PPPERVTEEQPTDLSLPKSSPLKLPLSTSTLGGIPHAAIQQDIKNSPHFQAGNSQSSSVDYHPRACRVPPMTVSASKKVTESHSKVLEKTPNSRGEESMGFKIDEMSRPILSTKSSPQNICTARPLKRNIEDLENGPTEKKIRAVTPLHCSTQRDLPGKPRTPEADSESVKPAEPAVHINSYTSEGHKIPLHSHLFQGLYPGTFVSQVQDMCESLGSHVTPSYSHPLQYLKNQAVLSPLMPPFAIHSLMMQRQFLAA--NPAHMYRH-----QVGTSYGDILHPGLYPMSALHPQPAFSPPQLSSVHPSTKLS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P09547-1", "uniprot_id": "SWI1_YEAST", "id": "P09547-1", "name": "SWI/SNF chromatin-remodeling complex subunit SWI1", "aln": "MDFFNLNNNNNNNNTTTTTTTTNNNNTNNNNTNNNNNPANNTNNNNSTGHSSNTNNNTNNNNTNTGASGVDDFQNFFDPKPFDQNLDSNNNNSNSNNNDNNNSNTVASSTNFTSPTAVVNNAAPANVTGGKAANFIQNQSPQFNSPYDSNNSNTNLNSLSPQAILAKNSIIDSSNLPLQAQQQLYGGNNNNNSTGIANDNVITPHFITNVQSISQNSSSSTPNTNSNSTPNANQQFLPFNNSASNNGNLTSNQLISNYAASNSMDRSSSASNEFVPNTSDNNNNSNNHNMRNNSNNKTSNNNNVTAVPAATPANTNNSTSNANTVFSERAAMFAALQQKQQQRFQALQQQQQQQQNQQQQNQQPQQQQQQQQNPKFLQSQRQQQQRSILQSLNPALQEKISTELNNKQYELFMKSLIENCKKRNMPLQSIPEIGNRKINLFYLYMLVQKFGGADQVTRTQQWSMVAQRLQ-----ISDYQQLESIYFRILLPYERHMISQEGIKETQAKRIFLQQFLQELLKKVQQQQQAAALANANNNINSASSAPTPAAPGASVPATAAPGTEAGIVPVSANTPKSLNSNININVNNNNIGQQQVKKPRKQRVKKKTKKELELERKEREDFQKRQQKLLEDQQRQQKLLLETKLRQQYEIELKKLPKVYKRSIVRNYKPLINRLKHYNGYDINYISKIGEKIDSNKPIFLFAPELGAINLHALSMSLQSKNLGEINTALNTLLVTSADSNLKISLVKYPELLDSLAILGMNLLSNLSQNVVPYHRNTSDYYYEDAGSNQYYVTQHDKMVDKIFEKVNNNATLTPNDSNDEKVTILVDSLTGNQLPTPTPTEMEPDLDTECFISMQSTSPAVKQWDLLPEPIRFLPNQFPLKIHRTPYLTSLKKIKDEIDDPFTKINTRGAEDPKVLINDQLSTISMILRNISFSDNNSRIMSRNFYLKRFISDLLWLVLIHPENFTCNRKILNFKKDLVIVLSNISHLLEIASSIDCLLILILVISFGQPKLNPMASSSSFGSESLTFNEFQLQWGKYQTFGVDILAKLFSLEKPNLNYFKSILLNKNTGNNLYDRNSNNNHKDKKLLRRLLNLYNDN--NKNNNNRHNLLNDVVSFLFSAIPLQQVLSQSADPSLLIDQFSPVISQSLTSILVIVQKILPLS--NEVFEISENNSDSNSNNNGNKDSSFNFNKNLPFVWLSSEENIGSGLLKLSEIILNINNSTSKNTLLQQQNYSKVLLPSINISCVQLIKCLVEKSICFEN----CLNNDPEILKKIASIPNLFPTDLEIFQLFTNPSVDIQIINQYQLLYNLKNDILTNLE", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .:: . . .: : : :.:*.. .: :** *:. :* . :. :: *: .: : : .: * :: . :. .. ..:. .. : ... : . . : . .* :: .* *. : . :*:: ::. . .: : : : : . : . :: . : . : : . : : *: :* : *:*: *:: ** :* ::***: :: .**:** : :* :**. : :.* * . * *::*****. .:*. . * : ** *.: : . . . :.. . . : :. : : : . . .. . . . . . * : . . :. : :.: . : .: : :* : * : .: : .: : : . :..* : . ..: * . . . .:: . . .: . *:* * . .: . : : : : :. : : . . . : : :** . .: .* . * : : :. .. : . : : : . :. . .*:: : :. :. : . .:. : : : .. . :: : : : . .: :. : .* : .*. .: :.: :. : . . * : .: . . .... : . . :. : ** : . .: : : . : *: :. :*: ::. . * .: :: : .: :::: * :: : . . *:* ", "identical_positions": 67, "similar_positions": 320, "identity": "5.05%" }, { "cls_id": "homologset.agr.HGNC:17363", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZII7-1", "uniprot_id": "D3ZII7_RAT", "id": "D3ZII7-1", "name": "", "aln": "MKDDGPRRAGRTCVCGRQPPRPSGRASHGLSAPGGERVSRREAAPRTRRGCWAALPAFEVSGAAAGWPARVTCARAGVSPTAGGCVGSGGGGGGGGGGCSSRRGLPRPLASALPPAPRLGADRRAAASRASAASMGDKK--SPTRPKRQPKPASDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKDKSEKEAASKKNCHKRTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKAK--SAPASGAAAADQHSQSSCSSDTTERGLSRSSSPRGEASSLNGESH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99LW6-1", "uniprot_id": "YAF2_MOUSE", "id": "Q99LW6-1", "name": "YY1-associated factor 2", "aln": "--------------------------------------------------------------------------------------------------------------------------------------MGDKK--SPTRPKRQPKPASDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDRVEKDKSEKEAASKKNCHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKAK--SAPAS-SAAGDQHSQGSCSSDSTERGVSRSSSPRGEASSLNGESH", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8IY57-1", "uniprot_id": "YAF2_HUMAN", "id": "Q8IY57-1", "name": "YY1-associated factor 2", "aln": "--------------------------------------------------------------------------------------------------------------------------------------MGDKK--SPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTK--SPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5SP48-1", "uniprot_id": "Q5SP48_DANRE", "id": "Q5SP48-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------MADWLFYQPKVPKRQAKPSSDDGYWDCSVCTFKNTAEAFKCMMCDVRKGTSTRKPRPVSQLVSQQVTQQFASATLPKKEKKEKTEKDKNEREPTLKKNNHKKMRPRLKNVDRSSAQHLEVTVGDLTVIITDYKEKTKPSSSSSSSATSADHHSQSGSNSDNTEKGISRSSSPRGEVSSLNGESH", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W215-1", "uniprot_id": "Q9W215_DROME", "id": "Q9W215-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------------------------MDKKS--SPVRRQKRQAKVIEENFWDCSVCTYRNSAEAFKCRMCDVRKGTSTRKPRLNSALVAQQAATLPGASVNMPNGKSASGSRHGSGHD----RQRHKRYPARLKNVDRSTAQTREVTVNSVTVFITEYKAKPV------------------SSRRESSEQSFSESNDSRS----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . .* ::: ::.:*******::*:****** ************** * **:**.: ... : *. .:. . :: :: **: .********:** ****..:**:**::* *. .. :.:*:..*.*...*. ", "identical_positions": 62, "similar_positions": 51, "identity": "19.5%" }, { "cls_id": "homologset.agr.HGNC:17364", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A096MJF6-1", "uniprot_id": "A0A096MJF6_RAT", "id": "A0A096MJF6-1", "name": "Protein DBF4 homolog A", "aln": "MNLETMRIHSKAPLPGGIQDKNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYLVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSN-ALSWGVKILHIDDIRYYIEQKKKALGALKKPNTSGRDSGKKAGTGIQKARTGRLKKPFLKVEDVNRTYKPFYLQLPS---MPCINYFLQKPCSPFDIDKSSSMQKHTQPKLKINTDGDKYG-----------TPAQVQLKEK-------------------RKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSKLIFDFVEYERDTPKKKRIRYSVGS-------------------------------------------------------LSSVSASVLQNTEPREKLLLEPSFQKDGEESNGQLLEQ------------------------------------------------------------NLQCEETQKPEEK----------------------------HVFGSEPTTYSSTGFKGCVGKP---VSLIN-------------------ASEPDLKPDCEQLPLR-------DNKQEGMRVGSEHKITVDRKDVDQRGGVTPCVPQSC---TYFSTDSN---------------------------------------------------------------------LPQPKLTADITQFSAQDLQEKDLH-VIGHDSELVTLNSSREQLTVKARPPPCSP-QEPHEGHSEH---------------------MESLPCGKIQRKVRMLLGQ----------------------------------------------------KKANVEPGAEWDKNRTEYLPAHGD--RTCGSPVQSLLDLFQTSGEKSEFLGFTSYTENSGICD----VLDIWEEDNSS-----------SLLSTFFSSPSTSAFVGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZ41-1", "uniprot_id": "DBF4A_MOUSE", "id": "Q9QZ41-1", "name": "Protein DBF4 homolog A", "aln": "MNLETMRIHSKAPLPGGIQDRNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYFVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSN-ALSWGVKILHIDDIRYYIEQKKKALSALKKSSASGKDAGKKAGPGIQKTRTGRLKKPFLKVEDVNRCYRPFYLQLPS---LPCINYFLQKPCSPFDIEKSSSVQKQAQPKLRINMDGDKCG-----------TPVQLQLKEK-------------------RKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSQLVFDFVEYGRDTPQKKRIRYSVGS-------------------------------------------------------LSSVSANVLKNTAPKEKPLLEPNFQKDVGESSGHLLKP------------------------------------------------------------NSQYEETQKPEEK----------------------------HGFASEPTTYSSAGLKGCDRKP---VSMFN-------------------ASEPDPEQEYAQLPLR-------DSTP-------EHQVTEGRNDGEQRVDPAPGVSQSCGQVSHLSTESN---------------------------------------------------------------------LPQPQLAADITQLSAKDLQEKGFHVVIGHASDLVALNTSKEQLTMKARTPPCSP-QEPHECDTEN---------------------MENLPCGKIQRKVRMLLGQ----------------------------------------------------QKANAEPSAELDKKRTEYLPAHED--RTCGSPVQSLLDLFQTSEEKSEFLGFTGYTENSGICD----VLDIWEEENSS-----------TLLSTFFSSPSTSAFVGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UBU7-1", "uniprot_id": "DBF4A_HUMAN", "id": "Q9UBU7-1", "name": "Protein DBF4 homolog A", "aln": "MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSN-ALSWGVKILHIDDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTN---MPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGG----------TSIQLQLKEK-------------------KKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGS-------------------------------------------------------LSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQ------------------------------------------------------------NFLYKETQETEKK----------------------------LLFISEPIPHPSNELRGLNEKMSNKCSMLS-------------------TAEDDIRQNFTQLPLH-------KNKQECILDISEHTLSEN-DLEELRVDHYKCNIQASVHVSDFSTDNS---------------------------------------------------------------------GSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKN---------------------MDSLPSGKIHRKVKIILGRN---------------------------------------------------RKENLEPNAEFDK-RTEFITQEEN--RICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICN----VLDIWEEENSD-----------NLLTAFFSSPSTSTFTGF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9NK54-1", "uniprot_id": "CHIF_DROME", "id": "Q9NK54-1", "name": "Protein chiffon", "aln": "MQPQSDKQSASRLATTTSHSTAAASATAATPPKVKVIKSK---RPLCHFKFYLDICDHQLAKRIESDIKALGGHLEFFLSDDITHFVTDK-----PEVIGGTSGTPG-TPSTPGTPTSHYQQNDGSARKPNQRQSRADAILSRVRRSTVGVVNSGNSTPTT-SLKRSYTIWQTDYAQRFIKRIQTELKQYLEGKKEGGGGSTSASP-----HHIQLKKQYVKIESVKRNYRPYYHLIKQPDDWPKIDLSSEDGAFRLLTKSKTKDKEHSMTRKPLGSRTSQKDKQAAGEAKPLQHPSLQELKKQSAIPNSPRSNCREPIDSSEKQGGVCEICKLEYDILNIHLQSKDHELFAKNSDNFLALDTLIQSSADVNRFLEEEPVESELDMDVDESLSNEELQSPRQRPSPALREKSKRITKGKHSSEKFQGVAVASPQTPFPGAKKVQGNSPGSLSELQRQEHPTTAAATPTTNSGRRKTQNSGLSPPKRAMLPPSSIYKVVETREECATPPRGRGRPPNQVDSPSLIVKFQKIRQTELQRLNGEAENFMFPRTAVPTTRSSSELPTDVDRQTTSDVRGRYSISSASLDTSTSEAETKESSGLPTSIRKRAQAVGRRRKVGGAAAQDVFQRQLSTGSSSSNSNQQRFPSAPIQPEEGPQPQPKPQLKIKIKQEQLVATRKSSRTATAIVTAATASSHQQQQLRQTTCRKMANKLEDRMGELVKPKIKIKKEVIEEQKVKELEDLEEILDKELDEEVDSSCSSGSDEDYIAGSQRRITAAPRKSTDTREQRAARRLSRLTINRSAGELELTEVKTSPSKSRTKIQKPSSPTKNKVKQTKAVPPAIDLFFDCSKSERLREMQYTFESLPSGELWNRVFLRQDAGEENYYTYYGSTNYRKLPYEMGPIPMAKTLPAHSCALCREASEVKQDKGEQIKLEDQKPAPKKEVKKEEEVQSSSSS-ATYKNKKLHLLQRYQQEQEQLQQLEGNSLATAGAKCDSKASTPELLEREFASGSMGDRVQLIERVRSTSSSSCSNSQRSGITCRNKQLARIAELPPRKSPREHASTLALVSCIIRQRQDSQSKTNSEAEEPPPPVAAPKLKTPIKQEPVAPSSPRTTRSQAATPVEELRFATEISETVKRMRRGQNKYDHSPPAPVPTPATSSPVRSRRLTPAARNQSQIYSRRLEFATSQRESSASALLGKRKRRVNPSVAGTVRPTTQNLPGTGAYRGVRKLPSKKGLLEYEMETCALKALDQARQYCNPGFVAWQLDKYLELAGKEYDIEFDQISPEVESEGREERLVNTPQTPPPTDCFTSEFDLCDLIMGSAGSGDDDEDVSRGNPPGSGRRMSNLNLYASYYRKRKSLKSNRTGWPKAQRRRNAGGLGGSRALPDERINFQKMGLAELHPIKQEPMETEEEQTTTTTTTTTTSATRGNLLSKDDEDDEGGGNSPSGGSPADDKQNSREDAVMTPPATDVDEQAEPQADEMESLPDEDETMADSVDQQQDVEAEIEATDADVEEEEEEEDEDEDVFEDAYEEQDMGIQKTEPHEKRARIPSISVTTPPEDSSQGKKLLLTLHNGQRLQATSTPSTGQVQQHQRRTPQLNGSLGSCISPSEKLGDNSDIFTVSSDGLDTDLDLSNTQAGDSHEHCPHQTTPKRKFDISKYAPPNSGKAASSCAAEAATAAVKSLAISQFLKKETCASSSSMRNAWRRTQRRAISAACISAAPSARVPN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P32325-1", "uniprot_id": "DBF4_YEAST", "id": "P32325-1", "name": "DDK kinase regulatory subunit DBF4", "aln": "-MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAG-------HLNVFSNDNNCNNNNTTESFPKKRSLERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDT--DILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHNEKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQT----------WAPIITLEWK--------------------PQELTNLDELPYPILKIGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADT-----------------------------------------------------------LLNTSSVNDQTKNLIFIPHTCNDSTKSFKKWMQEK---------------------------------------------------------AKNFEKTELKKTDDS-----------------------AVQDVRNEHADQTDEKNSILLNETETKEPPLKEEK-------------------ENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDLCTLKTKSRQAFEIKASGAHQSNDVA---------------------------------------------------------------------TSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQTNGNNKNYTATIATTAETSKENRHRLDFNALK-------------------KDEAPSKETGKDSAVHLETN--------------------------------------------RKPQNFPKVATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGYCENCRVKYESLEQHIVS----------EKHLSFAENDLNFEAIDSLIENLRFQI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : . : .. . : : . . : .:: * : : .* .. : . :. : . . . : . * . . . . .. . *. . * : * : : . . . . . ::* .:. : . :. . :. .. : . . *: : : * *: .. :. : : : * . . : .. . . . .. : . * . . :: . : . . . . * : . . .. . . . . : : . .: . .. :: :. . :. *. : . : : . .. . . : . . : :: . : . . .. *: : *.. . : .. . . .: ", "identical_positions": 16, "similar_positions": 155, "identity": "0.93%" }, { "cls_id": "homologset.agr.HGNC:17366", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A2VCW9-1", "uniprot_id": "AASS_RAT", "id": "A2VCW9-1", "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "aln": "MLRAQRLRLARLRACVSRG-------LHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGHWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYISRFNADIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKSSVVPVEG-CPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMS----TKKKVLVLGSGYVSGPVLEYLSRGNNIEITLGSDMTNQMQQLSKKY-DINTVNVTVGKQEDKLQSLVESQDLVISLLPYVLHPVVAKACIDSKVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDKAKDLGATIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIS-SAHTLLRGTLRYKGYSKALNGFVKLGLINRETYPALRPEANPLTWKQLLCDLVGISRSSSCEKLKEVVFTKLGGDSTQ----LEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIETKGLMGPFSKEIYGPILERIKAEGIVFNTQSTIKL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99K67-1", "uniprot_id": "AASS_MOUSE", "id": "Q99K67-1", "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "aln": "MLRAQRPRLARLRACLSRG-------LHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMNLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELREVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYTSRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKSSVVPVEG-CPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQQIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMS----TKKKVLVLGSGYVSGPVLEYLSRDNNIEITLGSDMTNQMQQLSKKY-NINPVSLTVGKQEAKLQSLVESQDLVISLLPYVLHPVVAKACIESRVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDTAKELGATVESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSIKYAEIYGIS-SAHTLLRGTLRYKGYSKALNGFVKLGLINREAYPALRPEANPLTWKQLLCDLVGISRSSPCEKLKEVVFTKLGGDNTQ----LEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIEAKGLMGPFTKEIYGPILERIKAEGIVFNTQSTIKL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UDR5-1", "uniprot_id": "AASS_HUMAN", "id": "Q9UDR5-1", "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "aln": "MLQVHRTGLGRLGVSLSKG-------LHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEG-CPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMG----TRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKY-NINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGIS-SAHTLLRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLKEAVLKKLGGDNTQ----LEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FD66-1", "uniprot_id": "E7FD66_DANRE", "id": "E7FD66-1", "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "aln": "MLRLVRSQGRGFRGCMCCQRRSQHNQQNHKSVIAIRREDVNVWERRAPLAPRHVREITAAGHKVLVQPSNRRAIHDRYYEKAGAVIQEDISEASLIIGVKRPPEEKVYPRKTYAFFSHTIKAQEANMGLLDDLLKKEVRLIDYEKMVDPNGYRIVAFGQWAGVAGMINILHGLGLRFLALGHHTPFMHIGMAHNYRNVSQAIQAVRDCGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQDIFNELPCEFVEPHELKEVSLSGDLTKVYATVISRHHHLMRRSDGLYDPLEYENHPELYTSHFRDTVAPYTTCLINGIYWDPHTPRLLRRLDAQRLIRPVVTTSSSADYGCPALPHKFLAICDISADTGGSIEFMTECTTIEKPFCMYDANQHIDHDSVEGNGILMCSIDNLPAQLPIEATEYFGDRLFPYVMEMLPSDATKPLEEEDFSPQVRDAVITSNGKLTPKFEYIQKLRERRESEQILKKG----GMKRVLLLGAGYVSGPVIEYLTRDAGTQVTVASNLLNQAEEMATRYPNTIAVMLDITSQEGHLESLIKDHDIVISMLPYSFHPQVAKHCIKLKVNMVTASYLSPAMKELQKSAEDAGITIVNEMGLDPGIDHMLAMECIDQAKADGCTVESYSSFCGGLPAPECSDNPLRYKFSWSPYGVLLNTISPAIYLKDNQIVSVPPGGALLDVTKEMDFMPGFNLEGFPNRDSTKYAEPYGIE-SAHTLIRGTLRFRGFSSAMSGFVKLGLINTEPCPLLDHTASPVSWKELLCKQIGLSATVSNSVFEDAVYEKIGKDDFR----MQSLKWLGLLGEEPVPHAETILAAVAKHLEAKLSFDKGERDMIIMRNDVGIRHPTGELETKHISLVVYGDPSGYSAMAKTVGYPAAIAAHMVLNGELTTKGLVVPMVKSIYSPVLKRLQDEGLQFITKSSVSE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLX0-1", "uniprot_id": "Q9VLX0_DROME", "id": "Q9VLX0-1", "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "aln": "MWRVIQLR-ATIAHPFTRQ--------RHSRVIAIRREDQSVWERRAPFGPTHVQKLVKQNVKVIVQPSNRRAYPMQAYMQAGAHIQEDISDASVIFGVKQVPIDALIPGKTYCFFSHTIKAQESNMPLLDAILEKKIRLIDYERIIDERGARQVAFGKYAGVAGMVNILHGIGLRLLALGHHTPFMHIGPAHNYRNSSMARQAIRDCGYEISLGMMPKSIGPLTFVFTGSGNVSQGAQEVFSELPIEYVPPEMLRKVAEHGNQNKLYGCEVSRSDHLERREGGGFDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLISIPDAKNLLRPANTPWLPTSKGSPALPHRMLAICDISADPGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKGPGVLVCSIDNMPTQLPRESTDLFGELLAPHVHDIIKSDAKKPLAEENFSYPIQSAIIASNGQLTEGFQYIQELRESQSHRSRHKMEGSSESDKKVLVLGAGMVSAPLVEWLHREKDVSITVCSQVKEEADRLAQQYAGVDSVYLDVNESTGHLQELCGRADVVVSLLPYSLHGMVARYCVAEGTHMVTASYLNDEISGLHEEAKAKGVTIMNEVGLDPGIDHLLALECIHEVQDKGAVVESFVSYCGGLPAPEHSNNALRYKFSWSPRGVLLNTLSAAKYLSQGQIVEISGGGELMSSPRSLDFLPGFALEGFPNRDSTKYGNLYGLGRDVHTLLRGTIRYKGFSESIKPMQLLGLIDPEPHALLHPSGPDVTWRQLVIHLMGMSDS---TIFYENLKQKLTERIGD----VDGIESLGLLDDTPVVKLNTPLDTLSHYLSKRLAFERDERDLVVLRHEVGIRWPDGRREERGINFVVYGQPQGHSAMAMTVGKPAAIAAKMILDGEIQERGVLLPFTPDIYRPMLQRLRSEGLTATETSRWLN", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38999-1", "uniprot_id": "LYS9_YEAST", "id": "P38999-1", "name": "Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]", "aln": "----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG------KNVLLLGSGFVAQPVIDTLAANDDINVTVACRTLANAQALAKPS-GSKAISLDVTDDS-ALDKVLADNDVVISLIPYTFHPNVVKSAIRTKTDVVTSSYISPALRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNSAKYWKDGKIETVSSE-DLMATAKPYFIYPGYAFVCYPNRDSTLFKDLYHIP-EAETVIRGTLRYQGFPEFVKALVDMGMLKDDANEIFS---KPIAWNEALKQYLGAKSTSKEDLIASIDSKATWKDDEDRERILSGFAWLGLFSDAKITPRGNALDTLCARLEELMQYEDNERDMVVLQHKFGIEWADGTTETRTSTLVDYGKVGGYSSMAATVGYPVAIATKFVLDGTIKGPGLLAPYSPEINDPIMKELKDKYGIYLKEKTVA-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.**:**:* :: *::: * . .:*: . : : :. . .: : : .. * : *:*:*::** :* *.: .: ..:**:**:. : *. . *:*::.*:*****:**: *:: *. .: * ::*: *:******** *:*.* ******. ***: ..* * :.:: :. :: ** : :***** : : * : ...*::***:*::*: . :. : :*::. :. : ::*.: : . :* . : : . :.. ***:.: : . : :.. * : : *:*:::::...**. . * * : :* **. *.*:** *** *.*:*::::*:* : *:: * .* *:::.:: : . ", "identical_positions": 104, "similar_positions": 159, "identity": "11.02%" }, { "cls_id": "homologset.agr.HGNC:17367", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A1V1-1", "uniprot_id": "D4A1V1_RAT", "id": "D4A1V1-1", "name": "Intraflagellar transport protein 57 homolog", "aln": "MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALP----TNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEET------DNEE-NFIDLNVLK--AQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BXG3-1", "uniprot_id": "IFT57_MOUSE", "id": "Q8BXG3-1", "name": "Intraflagellar transport protein 57 homolog", "aln": "MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALP----TNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEET------DNEE-NFIDLNVLK--AQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NWB7-1", "uniprot_id": "IFT57_HUMAN", "id": "Q9NWB7-1", "name": "Intraflagellar transport protein 57 homolog", "aln": "MTAALAVVTTSGLEDGVPRSRGEGTGEVVLERGPGAAYHMFVVMEDLVEKLKLLRYEEEFLRKSNLKAPSRHYFALP----TNPGEQFYMFCTLAAWLINKAGRPFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCFAEEALKYIGFTWKRPIYPVEELEEESVAEDDAELTLNKVDEEFVEEET------DNEE-NFIDLNVLK--AQTYHLDMNETAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHRSGIESALKETKGFLDKLHNEITRTLEKISSREKYINNQLENLVQEYRAAQAQLSEAKERYQQGNGGVTERTRLLSEVMEELEKVKQEMEEKGSSMTDGAPLVKIKQSLTKLKQETVEMDIRIGIVEHTLLQSKLKEKSNMTRNMHATVIPEPATGFY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6IVW0-1", "uniprot_id": "IFT57_DANRE", "id": "Q6IVW0-1", "name": "Intraflagellar transport protein 57 homolog", "aln": "MAEEE-------------------------ERGPGSVYQMFVLMEDLLDKLKVLDYEQHVLDKHNIKPLSRHYFVSSPHVLSNPGEQFYMFSVIAAWLITLCGRPFDTPQEYDDPNATVSNILSELRTLGGQVDFPPSKLKTGSGEHVCYVLDQLVEKALKSKGFAWNRPLYPSVEVEDECVQEDDAELTLSKVEEEMTQEDE------EYEEEDGLDLDALK--TRTN--GELSGSRPAVVLESDVDAAEWNLEVERVLPQLKVTIRTDNKDWRIHLDQMHQHQDGINTSLQDAKGCLFKLREDISKTLEKVSSREKYLNTQLEHLISEYRQAQSQLNKVKELYQQASGGVTERTRILAEISEELDKVKQEMEEKGSSMSDGAPVVKIRQSLTKLKQEIEQMDVRMGVVEHTLLQAKLREKNNMTRDMHATHLLEPNAQAY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VQS5-1", "uniprot_id": "IFT57_DROME", "id": "Q9VQS5-1", "name": "Intraflagellar transport protein 57 homolog", "aln": "MQQDD--------------------------EQEKSQQLQNFQSDDLLEKLKLLNYEKHLLKEFKLKPLSRFYFVKA----TNPGEQFYMFTLICWWLCKKLGKDMERPQEYDDPNTVAANIIKLLGEIDVPVDFQPNKLIRGAGPICLSVLEVLSTQACKVAQVGYQKLHIAQEEEFLGDYLEDNAEIILEKLEDEQNAAALSDDSDMELEAHNFRQLNWLNRPQKKSNGDVNLDERNPELDARMSDHQEWHLELERVLPQLKVFVKADARDWRTHISQMETLKTNILENSDTAEAQLKKLHSEFTFDLEKIESREKHLNNELKPLIQQFKELSIELSTIQYAQNQLQEDMEKQTAELNEVMMEQELKKEEMERRGQAMSDGSSVQQIRKAIAKLKDDTAQLNLEVALLVHAHDQDIVVRQLQQNQTTDLANNP-------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . : . :**::***:* **:..* : ::*. **.**. . :********* :. ** . *: :: ********:. :**:. * :. .** *.** * * **: : :* * . ::: . * **:**: *.*:::* : * : :*: *: :. . : : * ** **:********* :::* :*** *:.**. : .* . ::. * **:.::: ***: ****::*.:*: *:.::: . :*. : :* . .: ::* * *: * : *:***.:*.:*:**:.: :*:::::***:: ::::.:.:: *: * : .: : .: . : ", "identical_positions": 115, "similar_positions": 134, "identity": "26.02%" }, { "cls_id": "homologset.agr.HGNC:17368", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESJ7-1", "uniprot_id": "IKBP1_MOUSE", "id": "Q9ESJ7-1", "name": "Interleukin-1 receptor-associated kinase 1-binding protein 1", "aln": "MSLQPAPASRVFMELVPWADRGRENHPISAAEAQPIGRRP-HVAEAHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVSAEAKKSVCRRLDYITQSLQQQGFQAENVTVTKNIRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPEFYHTPGSVENLRRQACLVAVENAWRKAQEVCDLVGQTLGKPLLIKEEETKDWEGQTDDHQLSRLPGTLTVQQKIKSATIHAASKVFITFEVKGKEKKKKHL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VVH5-1", "uniprot_id": "IKBP1_HUMAN", "id": "Q5VVH5-1", "name": "Interleukin-1 receptor-associated kinase 1-binding protein 1", "aln": "MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQFYHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSSSLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q501X6-1", "uniprot_id": "IKBP1_DANRE", "id": "Q501X6-1", "name": "Interleukin-1 receptor-associated kinase 1-binding protein 1 homolog", "aln": "---MAHSPSRVFAALSPSAGDVYRDENQS---VFNRGRKQ-THLSAQSNVRVIEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTARQHDVKEENITVTKHLQRDEDLFHMQAEVLVVFLDFEKMQQARTVLIEKLDKSVCVGDPYYSHSAESLSLLRRRVCLEAVDNARLKASEACCTLGQALGRPLLVREEESREWSSSQQDASGS----PLTLHPRTDATLISATSRMFVTFELRPKDNNRRKF", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ..:*** * * *. .:. * . *: .*:. .* :.*:* :*:*: **** * : *..:** :..:** ***:** *: :*:..: **:****.::* *: :**:*** :.* :* ***: ..*:****.** :. * : *:. *:. ***:.** **:** **.*.* :**:**:***::***:::*... :* . * .**:: : .:: * *:*::*:***:: *::.::::", "identical_positions": 95, "similar_positions": 94, "identity": "36.54%" }, { "cls_id": "homologset.agr.HGNC:17369", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A8QI13-1", "uniprot_id": "A8QI13_DROME", "id": "A8QI13-1", "name": "Activator of basal transcription 1", "aln": "-----------------------MKEIKRKSKPKRKPTRMEVEEIET----SDKPQPEDGESANGEANPSDEGDEMELASFKAACSSSDPAKKI-----------------KKGIIYISNIPKHMTLTRLREILGEYGGIGRAFLRSQ-----------------SSKHHNILFAEGWVEFKSKHVAKQLVLLLNNKQISTRNNSPFYYSLWSMEYLPRFKWARLAELMNFVQVTNSQ---------------------NHLEFLKKKAKEAK----------------EVKKAMKVLADRLLELPLDSNI------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A8QI32-1", "uniprot_id": "A8QI32_DROME", "id": "A8QI32-1", "name": "Activator of basal transcription 1", "aln": "-----------------------MKEIKRKSKPKRKPTRMEVEEIET----SDKPQPEDGESANGEANPSDEGDEMELASFKAACSSSDPAKKI-----------------KKGIIYISNIPKHMTLTHLREILGEYGGIGRAFLRSQ-----------------SSKHHNILFAEGWVEFKSKHVAKQLVLLLNNKQISTRNNSPFYYSLWSMEYLPRFKWARLAELMNFVQVTNSQ---------------------NHLEFLKKKAKEAK----------------EVKKAMKVLADRLLELALDSNI------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VY84-1", "uniprot_id": "Q9VY84_DROME", "id": "Q9VY84-1", "name": "Activator of basal transcription 1", "aln": "-----------------------MKEIKKKSKPKRKPTRMEVEESEPEMPFSYKTQPDEGESVNGEAHTSDDGDEMELATFKAAS--------------------------KKGVIYISNLPKHMTLTRLREILGEYGAIGRAFLRSQKL---------------SRKPHNFLFAEGWVEFKSKRVAKQIVPLLNYKQISTHKKSPFYYSLWIMEYLPRFKWARLNELMNIVPVTNSQ---------------------NHLKFLNKKAKKAK----------------KVKKAKKALADRLLELVLASSI------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W394-1", "uniprot_id": "Q9W394_DROME", "id": "Q9W394-1", "name": "Activator of basal transcription 1", "aln": "-----------------------MKNIKNKSKPKRKPTPMEVEEAELDEVRSDEPQPGEGETANGEANPSDDDDDMDLANFKATSSSSAPAKKR-----------------KMGIIYISNIPKHMNVTRLREILGEYGAIGRVYLQPEKLSSAKAK-------KNKRKRYNIHFTEGWVEFKSKRVAKQIVPLLNNKQISGRKTSQFYDSLWSMKYLPRFKWVHLTERMNYEQAVHKQRLHTEVSQ-----------ARKETTFFQNNLDKSE----------------FIRKQAKKAKNAEKALAAKSDSDA----------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W393-1", "uniprot_id": "Q9W393_DROME", "id": "Q9W393-1", "name": "Activator of basal transcription 1", "aln": "---------------------------------------MKVEETKLDEARWGKPQTKEGESANGIANPSND-DKKELANFKATFNSWAPEKKREKM-------------HKVGVILISNIPKDMDGDCLKEIMNLHSVVGRVYVQPETL---------------SSFKTKKNMRKGWVEFISKSGAKKIALELNNKPITDGKSSRFRGLLWKMKFLPRFKWYYLTDRMDYELAVCKVRVWSQARKRA-----TFWYDPDQMEYFKKQVKKMKKMK-------------KVKEAEMATRNAEMAAKKAEMAAKKLKKSA----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q8IRM9-1", "uniprot_id": "Q8IRM9_DROME", "id": "Q8IRM9-1", "name": "Activator of basal transcription 1", "aln": "---------------------------------------MKVEETKLGEVRSGKPQTKEGESANGVANPSND-DKKELANFKATFNSWAPEKKREKM-------------HKVGVILISNIPKDMDGDCLKEIMNLHSVVGRVYVQPETL---------------SSFKTKKNMRKGWVEFISKSGAKKIALELNNKPITDGKSSRFRGLLWKMKFLPRFKWYYLTDRMDYELAVCKVRVWSQARKRA-----TFLYDPDQMEYFKKQVKKMK----------------KVKKAEMATRNAEMAAKKAEMAAKKLKKSA----------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q4KLM5-1", "uniprot_id": "ABT1_RAT", "id": "Q4KLM5-1", "name": "Activator of basal transcription 1", "aln": "-------------------------------------------MVKVGKLVEEQKAAMEEEKEV----NAEAAEELEEAEEASCNGS---KKKVVP-----------------GIVYLGHVPPRFRPLHVRNLLSVYGEVGRVFFQAEDPFVRRKKKAAAAAGGKKGAKYSKDYTEGWVEFRDKRIAKRVAASLHNTPMGARKRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKRETDFYLRNVEQGQRFLAADGDATRPNSSWTFTQRPTEQELRAQKGARPGGRERARLATVQDQARSNRGLLARIFGASLLAESRKEP------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QYL7-1", "uniprot_id": "ABT1_MOUSE", "id": "Q9QYL7-1", "name": "Activator of basal transcription 1", "aln": "-------------------------------------------MVKAGELVEQQKAAMEEEA------NAEAAEDQEEPEDTACSSSSKKKKKVVP-----------------GIVYLGHVPPRFRPLHVRNLLSAYGEVGRVFFQAEDHFVKRKKKAAAAAGGKKGAKYSKDYTEGWVEFRDKRVAKRVAASLHNTPMGARKRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKRETDFYLRNVEQGQHFLAADGDATRPNSSWTFTQRPTEQEFRARKAARPGGRERARLANVEDQARSNRGLLAKIFGAPLPAESKEKP------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9ULW3-1", "uniprot_id": "ABT1_HUMAN", "id": "Q9ULW3-1", "name": "Activator of basal transcription 1", "aln": "-----------------------------------------------MEAEESEKAATEQEPLEGTEQTLDAEEEQEESEEAACGSK----KRVVP-----------------GIVYLGHIPPRFRPLHVRNLLSAYGEVGRVFFQAEDRFVRRKKKAAAAAGGKK-RSYTKDYTEGWVEFRDKRIAKRVAASLHNTPMGARRRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKRETDFYLQSVERGQRFLAADGDPARPDGSWTFAQRPTEQELRARKAARPGGRERARLATAQDKARSNKGLLARIFGAPPPSESMEGPSLVRDS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "P53743-1", "uniprot_id": "ESF2_YEAST", "id": "P53743-1", "name": "Pre-rRNA-processing protein ESF2", "aln": "MSEKVNSDFEDFSSDEETDQHNVLIQTKKKISSKDDIFSKKVEDIESENESDIEEEQKQEEKEDVEQPDKENGEKLDREVEEQASSTTSLDLKTEKLRQLVKSKAAKKSKHKTGVVYFSSIPPYMKPAKMRQILTRFGEVDRLFLKKEDDQKYKQR-------VKGGGNKKNKYEEGWAEFIRKRDAKLCAETLNGNIIGGKKGTFYHDDILNVKYLPGFKWADLTEQIARENDIRQAKLEMEISQANKLNAEFIRNVEQSKMIQNIKNSRKRAGKEGESADSHPHREFKQRRVETSRANAPSDIKQQSSGSKDLGNVLTNLL------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * : :. : *:: :. :* : ::::: .. :.* :.: : . :**.** * ** . *: . : . : : : :::* *.* * : : . . . :. . ", "identical_positions": 16, "similar_positions": 48, "identity": "4.69%" }, { "cls_id": "homologset.agr.HGNC:1737", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O54874-1", "uniprot_id": "MRCKA_RAT", "id": "O54874-1", "name": "Serine/threonine-protein kinase MRCK alpha", "aln": "-------------MSGEVRLRQLEQFILDGPAQ----------TNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTD---VSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKAFEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDRKLREQSRHYSKQLENELEGLKQKQISYSP-GICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEIMVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNS-SLGTRATDMP-WKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELR--------------------------SEKGVEHRDSQHSFLA----------FLNTPTDALDQFERSPSCTPAGKGRRIADSAPLPVHTPTLRKKGCPASAGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPSSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSD-KCSILMLADSETERSKWVGVLSELHKVLKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERVALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGA--LSCLCVAMKR-----QVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEH-LCVGFQSGFLRYPLNGEGSPCNMLHSNDHTLAFITHQPMDAICAVEISNK------EYLLCFSSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSIYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPSPSEGSLSSGGVDQGSDAPVRDYDGEDSDSPRHSTASNSSNLSSPPSPVSPRKTKSLSLESTDRGSWDP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q3UU96-1", "uniprot_id": "MRCKA_MOUSE", "id": "Q3UU96-1", "name": "Serine/threonine-protein kinase MRCK alpha", "aln": "-------------MSGEVRLRQLEQFILDGPAQ----------TNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTD---VSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSP-GICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNS-SLGTRATDMP-WKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNILTECKLKDSEKKNLELLSEIEQLIKDTEELR--------------------------SEKGIEHQDSQHSFLA----------FLNTPTDALDQFE-------------IADCAPLPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSN-KCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGA--LSCLCVAMKR-----QVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEH-LCVGFQSGFLRYPLNGEGGPCNMLHSNDHTLSFISHQPMDALCAVEISNK------EYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPSPSEGSLSSGGMDQGSDAPARDYDGEDSDSPRHSTASNSSNLSSPPSPISPQKTKSLSLESTDRGSWDP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VT25-1", "uniprot_id": "MRCKA_HUMAN", "id": "Q5VT25-1", "name": "Serine/threonine-protein kinase MRCK alpha", "aln": "-------------MSGEVRLRQLEQFILDGPAQ----------TNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTD---VSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSP-GVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNS-SLGTRATDMP-WKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELR--------------------------SEKGIEHQDSQHSFLA----------FLNTPTDALDQFERSPSCTPASKGRRTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNN-KCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGA--LTCLCVAMKR-----QVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQ-LCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSK------EYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5TZ37-1", "uniprot_id": "Q5TZ37_DANRE", "id": "Q5TZ37-1", "name": "Serine/threonine-protein kinase MRCK alpha", "aln": "-------------MSVEVRLKKLEKLIMDGPSQ----------SSGQCFSMETLLDILVCLYDECSSSPIRREKNVLEFLDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNGDCQWITTLHYAFQDENNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPLQVTD---VSEDAKDLVRRLICSREHRLGQNGIEDFKQHPFFTGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNCETLPPPSHTAFSGHHLPFVGFTYTSKCTLSDRGCLRESVGP--AQVDAHVQRSLEESLASEAYERRIRRLEQEKTELTRKLQESTQTVQALQYPDSDAPVNANKEVEIRSLKSEIDILKKQIADSGQMEQQLENASTARRDLEDSSKVVRNLEKQLKSVTQEKDDLHKELLGLAEKVKAQGKELKDAHSQKKMAIKEFAELNEQLSDVRTQKQRLSRQFKDKEEEMEGVSQKLEALRLEIRKAERMRKELEAQAEEHAAEAQKERKVRERTEQYSKQLEEELEGMKQLKQTGPPNGAASSDQQQELMRVRAELEKKSVQYEEEMCRRETLHSSEMKNLQKELRDAEGQHLTHQKEILVLKDKLEKTRRESQVEREEFVCEYKQKYEREKAHLTDENKKLSAEVEKLNGQFEQLSSSHRQLEEEMRELADKKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLRNT-SLGARGTDMP-WKMRRFAKLDMSARLELQSALDTEIRAKQSIQDELNKVKATNIATECKLQESESRNQELLGEIERLRKETEELR--------------------------LRRGVKHQDSQNSFLA----------FLNAPTSALDQFD-------------LIDHTSRSLQTPTGRS-GYGSLGHSSPKPKAHQFSVKSFNVPTKCNQCTSLMVGLIRQGCTCEACSFSCHVTCADKAPSVCPVAPDQTRGKLGIDTQRGIGTAYEGHLRVPKPTGVKKGWQRVWAVVCDFKLFLYELGEGKGAQPGVVVNQVIDMRDEEFSASSVLESDVIHANRKDIPCIFRVTASQLSASSSQKTCILILADNEQERTKWVCALNELHRILRKNKLKERFVYVPKEAYDSTLPLIKTTQTAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDVKKVHHVELMPTEHILAVISGRNRQVCLVSMAGLDGREVDKNKVADTKNCQLLVSGVVRN----VTCFCLAIKR-----QISCFEINKSKSRHSHLVDIQAPGTVQWMALFNQQ-LCVGYPSGFMRYSLYGETPPASLLHPDDPTLAFIKTDNLDALCAVEISNK------ELLLCFSKIAVYVDTHGRRSRQQELMWPAAPTACCYNAPYLSVYSENAVDVFDVNSTEWIQTIPLKKVRPLNMDGSLNLLGLETVRLIYFRNKTAEGDELVVPEVCDNSRKQMVRSMSNKRRFSFRIPEEERLQQRREMLKDPERRNKLISNPTNFNHVAHMGPGDGMQILRDLPMNVRAQDNRAGFSGSVSIPSITKNRAEPGRSMSASSGLGMRSSSQNGSALRRELSSGSYSSKRQTMTSPSESSLSSGGGMDVGEAPLSQFDREDSDSPRHSTASNSSTFSSPPSPASPHKTKSLSLESTDRTAWDT", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W1B0-1", "uniprot_id": "GEK_DROME", "id": "Q9W1B0-1", "name": "Serine/threonine-protein kinase Genghis Khan", "aln": "MEYESSEISDITTGSCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFS----LTSSSTLDS-------------KKNQSSGFGDDTLDT-----------------ISSPQLAILPSNNSETPVDS--------------------------------------------VQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFS-------EKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED---DEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLS--LNTLMLADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIHTKG---LLQYRDGNRKGLP---SIKRRFSIREINKTIKSDRR---------SKMISAPTNFNHISHMGPGDGIQNQRLLDLPT-----------------------------------TLETADQACSPIIHSLSCIPQSRKSNFLEQVDANSDDYG---------------------------NDNIISRTPSPMASSFMDGLSNND--------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : ** *: :: * .:: :.*: **:: *** :: *****..*.:****.: ::*. :***. *:::** ::**:***:*********.**:: .::**:*************************** ** :***.*******: ********* *************:***:**:**::**::**:*:**::**********:*:* .**:*********:* :******.**************:*******:**.************************************:: *::* * * *** ::**: :*** *:*******:** .**:* ****.*** ***:****************: :: :::**.::.****.****:***:: *:. . * ::. ...:. :: : *: : * : *: : :: :.*: :: **: :* *: *::* *..**:** .*:::*: *: *:.*:*::::.***:*:*:.:*****:: . ** ::** *:*:::: ::*** : * ** *::*:**::.. .:**: **. .. : * . .* . *: ::. ::. *::.::: * *:: *:::: : *. :*: **: :::*: *: ** : * * *:::: ** :*:::*::*:: . :.*. . :* .::* *:*::: ** *::********************:******* *:: ::. ...* *: ** *** *:*****: **:**: *.:**.:.:: * *: :::: :.: .:* :::: .: .:*: :. : ** .** * . :. * ::: : : . . . : *** *::*. ****::******** *** ** *.*:** * :*.*:.***. :**: ****. :*:******::::**. :*:** * .:*********::. .: : * :.**:**** ***..** ****** :**:****::.:: :.. . *:***.* *:.*** .*.***::*::*.: : :: :* *.**.**:.: :.** ::: **.*:*** ::: : ** *:*: **: :: : ::::.::.*::*:: *..: .*:. :.: *: ::*.* :* :*. : .: :*:** *: :*: ::::** : :: .* : ::.: * *.. *** * * ** . .::*.:: :*: . :**: .:** * ** *..:.:*.* :**:**::*:*:** *: : :* ::*:. :*:*:.:: **:*:: **: *** *.: * .:: ** : .: . : : *..** : . ***:*:* :: .:** .*:** ******::*******:* : * : .:: * *.: :.:* . . * : : . . .* . * *.. :* .*** :. ..** :. ", "identical_positions": 639, "similar_positions": 521, "identity": "35.26%" }, { "cls_id": "homologset.agr.HGNC:17371", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AXT1-1", "uniprot_id": "FHL5_RAT", "id": "Q6AXT1-1", "name": "Four and a half LIM domains protein 5", "aln": "MTSTQFDCQYCTASLLGKKYVLKDDNLYCISCYDRIFSNYCEQCKEPIESDSKDLCYKNRHWHEGCFRCNKCHHSLVEKPFVAKDERLLCTDCYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFRDQIWHKECFLCSG-CRKELYEEAFMSKDDFPFCLDCYNHLYAKKCAACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTQNMEILCRKCGSGADTDM-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WTX7-1", "uniprot_id": "FHL5_MOUSE", "id": "Q9WTX7-1", "name": "Four and a half LIM domains protein 5", "aln": "MTSSQFDCQYCTSSLIGKKYVLKDDNLYCISCYDRIFSNYCEQCKEPIESDSKDLCYKNRHWHEGCFRCNKCHHSLVEKPFVAKDDRLLCTDCYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFRDQIWHKECFLCSG-CRKELYEEAFMSKDDFPFCLDCYNHLYAKKCAACTKPITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTHNMEILCRKCGSGADTDA-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5TD97-1", "uniprot_id": "FHL5_HUMAN", "id": "Q5TD97-1", "name": "Four and a half LIM domains protein 5", "aln": "MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSG-CRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8MLQ2-1", "uniprot_id": "Q8MLQ2_DROME", "id": "Q8MLQ2-1", "name": "LIM zinc-binding domain-containing protein", "aln": "----------------------------------------------------------------------------------------------MS--ASICCRCNEKIWP--RAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARCSACRTPILERGVAAAERKWHEKCFRCVS-CSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKPID----RRAVVALSTKWHAKCFKCHHCRKRISAREFWIENGQPICAACQTVVPSPRNLSAQ", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VXC1-1", "uniprot_id": "Q9VXC1_DROME", "id": "Q9VXC1-1", "name": "LIM zinc-binding domain-containing protein", "aln": "----------------------------------------------------------------------------------------------MSEQPSICHKCNEVIQL--RIITALGKTWHPEHFVCKDCQCPITEASFNINDGQPVCSACFVSNYSGICHGCKRPILERTIKAMGETWHEECFLCRGPCMQQLAGSSFYEHDGLPYCRTDFEHMFAARCGNCKAPIT----ENAIVALDAKWHRECFKCKKCKTPITASSFVVEDNQPLCKACSD-----------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .* * :*:. * * : *: :* *.*:.* : : :. * *: .:.: * *: * . : . **::** * . * :.* * . :. :* :..::: :* * ** . : . :** :**:* :* : . * .: : :* * ", "identical_positions": 37, "similar_positions": 53, "identity": "12.76%" }, { "cls_id": "homologset.agr.HGNC:17372", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6GBD2-1", "uniprot_id": "A0A8I6GBD2_RAT", "id": "A0A8I6GBD2-1", "name": "Actin-related protein 10", "aln": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMSKPIKVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTGAAKGQSLPSVMGSVPESVLEDIKVRTCFVSDLQRGLQIQAAKFNIDGNNERPSPPPNVDYPL-DGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLLQCPVDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKY--KKTLGTKNFRIHTPPAKANCVAWLGGAVFGALQDILGSRSISKEYYNQTGRTPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZB7-1", "uniprot_id": "ARP10_MOUSE", "id": "Q9QZB7-1", "name": "Actin-related protein 10", "aln": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMSKPIKVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPILNCWGALPLGGKALHKELETQLLEQCTVDTGAAKGQSLPSVMGSVPEGVLEDIKVRTCFVSDLKRGLQIQAAKFNIDGNNERPTPPPNVDYPL-DGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLLQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKY--KKTLGTKNFRIHTPPAKANCVAWLGGAVFGALQDILGSRSISKEYYNQTGRIPDWCSLNNPPLEMMFDVGKAQPPLMKRAFSTEK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NZ32-1", "uniprot_id": "ARP10_HUMAN", "id": "Q9NZ32-1", "name": "Actin-related protein 10", "aln": "MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLLEQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERPSPPPNVDYPL-DGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLAENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKY--KKALGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VWE8-1", "uniprot_id": "Q9VWE8_DROME", "id": "Q9VWE8-1", "name": "", "aln": "MPIYESVMQ--EKPPIVLDIGTAYTKLGFAAEAYPRKIMPTEVVMTTTGIRKRLFDYDT-PEELYDQLVDFLQTIFFKHLLVSPKERKFVLVENVFGSTVLRETLARVLFVHFDVSSVLFVPVHLIALSTLAVPTALVVDVGYSETSVMPVFSGVQIMAAFKDQSYGGSAIHAEIKRQLVESGVKES-------------LLTESVLEDIKVRTCFVTTMER------AKARANGDENQPTPAPDVDYIVSDNDAVIQVPGLLRESAYEIMFEASNERDSLPHLILRSILDCTLDVRRALVESVFLVGGGSMVQGLLARLRQELQHLLTEDPFYAERFHGELQFKFFNAVGKQNFTAWLGGALCGAT-DLIQTRSLVKETYLKSEHVPDWSNLCD-----------------NRPTGS--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**:**.: . **..:*:*:* *:** ***.*: ** *:*: : : ::.:*: .****. * :*:: ::*:****.*::*:.*::*.*: .: :****:**** :*:*.***:.* **:** **.: :*:*:* ** *: *:*::.*: :: .: . **.*:* *:: **:*. . :: :.*.******.*****: ::* ** . :*::::*:*.*:*** : *.: :::: * :*:*. **:** .**..*:. *** *:::*.:*.*: *.*.:.::** **: *:* ** *:::*: : : :: * *::... .* * .******: ** *:: :**: ** * :: : ***..* : :*. .: ", "identical_positions": 149, "similar_positions": 150, "identity": "35.48%" }, { "cls_id": "homologset.agr.HGNC:17376", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9WTP7-1", "uniprot_id": "KAD3_MOUSE", "id": "Q9WTP7-1", "name": "GTP:AMP phosphotransferase AK3, mitochondrial", "aln": "-------MGASGRLLRAVIMGAPGSGKGTVSSRITKHF-ELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCS----WLLDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIWPHVYSFLQTKVPETTQKASVTP", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P29411-1", "uniprot_id": "KAD3_RAT", "id": "P29411-1", "name": "GTP:AMP phosphotransferase AK3, mitochondrial", "aln": "-------MGASGRLLRAVIMGAPGSGKGTGSSRITKHF-ELKHLSSGDLLRQNMLQGTEIAVLAKSFIDQGKLIPDDDMTRLALHELKNLTQCS----WLLDGFPRTLPQAEALDRVYQ-----IDTVINLNVPFEVIKLRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIRPHVYSFLQMKVPETIQKASVTP", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UIJ7-1", "uniprot_id": "KAD3_HUMAN", "id": "Q9UIJ7-1", "name": "GTP:AMP phosphotransferase AK3, mitochondrial", "aln": "-------MGASARLLRAVIMGAPGSGKGTVSSRITTHF-ELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHELKNLTQYS----WLLDGFPRTLPQAEALDRAYQ-----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTETNKIWPYVYAFLQTKVPQRSQKASVTP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R4S7-1", "uniprot_id": "F1R4S7_DANRE", "id": "F1R4S7-1", "name": "GTP:AMP phosphotransferase AK3, mitochondrial", "aln": "-------MGLQS-VFRAVIMGAPGSGKGTVSSRIAQSF-GLKHLSSGDMLRANIEAKTDLGLLMKSCIDQGQLVPDDVISRLILSSLRGLEKTS----WLLDGFPRTVAQAEALDCVYD-----VDSVINLDVPFQTIRERLTSRWVHLPSGRVYNIDFNPPKKPGLDDVTGEPLVQRDDDSPETVSRRLKDYERQTQPVLEYYRSKGVLETFSGTETNKIWPHVHTFLSRKIPGHKQAMGKA-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VGU6-1", "uniprot_id": "KAD3_DROME", "id": "Q9VGU6-1", "name": "GTP:AMP phosphotransferase, mitochondrial", "aln": "---------MFTKIFRAVIIGAPGSGKGTISELICKNH-GCVHISTGDILRQNIIKNTELGKKAKQYIAEGKLVPDAIVTKTMLARITEVGNRS----YILDGFPRNIAQAEALAAREQ-----IDAVITLDVPHSVIIDRVKNRWIHAPSGRVYNIGFKNPKVPGKDDVTGEPLMQREDDKPHVVAKRLELYDEVMSPVIAWYEKKGLVATFKGKQTKEIWPMMELFLNDRINA---------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P26364-1", "uniprot_id": "KAD3_YEAST", "id": "P26364-1", "name": "GTP:AMP phosphotransferase, mitochondrial", "aln": "MKADAKQITHLLKPLRLLLLGAPGSGKGTQTSRLLKQIPQLSSISSGDILRQEIKSESTLGREATTYIAQGKLLPDDLITRLITFRLSALGWLKPSAMWLLDGFPRTTAQASALDELLKQHDASLNLVVELDVPESTILERIENRYVHVPSGRVYNLQYNPPKVPGLDDITGEPLTKRLDDTAEVFKKRLEEYKKTNEPLKDYYKKSGIFGTVSGETSDIIFRNY-------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* :::********* :. : :*:**:** :: : :. . * :*:*:** ::: : : . ::******. .**.** . :: *: *:** ..* *: *::* .******: :: ** * **:***** :* **..... :**: *. .*: :*...*:. *..* :. * ", "identical_positions": 66, "similar_positions": 66, "identity": "27.05%" }, { "cls_id": "homologset.agr.HGNC:17377", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AYP0-1", "uniprot_id": "ALLC_RAT", "id": "Q6AYP0-1", "name": "Probable inactive allantoicase", "aln": "---MADTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSNNPSFKENEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQG-IIRGIDVDISYFSGNYAPRMSIQAANLS-EDTVTNIPPRGVKMGAAATSEEFVAITELKSHSWDYLVPMSELKPGDPDSSHNYFFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGDPKSIADGWETARRLDRPPVLEGNENGFLQVPGCEWAVFRLAHPG-VITQIEIDTKYFKGNSPDSCKVDGCILTTLEEEDMIRQKWSLP-AHKWKPLLPVTKLTPNQNHLLDSLTLELQDVITHARITIAPDGGVSRLRLKGFPSSICLLRPLREKPMLRFSLKAGFRANL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JHX6-1", "uniprot_id": "ALLC_MOUSE", "id": "Q9JHX6-1", "name": "Probable inactive allantoicase", "aln": "---MTDTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSDSPTFKEHEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQG-IIRGIDVDISYFSGNHAPRMSIQAANLSEEDTMSNIPPRGVRMGTAATPEEFEAVTELKSHSWDYLVPMSELKLGDPDSSHNYYFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGEPKSIADGWETARRLDRPPVLEASENGLLLVPGCEWAVFRLAHPG-VITQIEIDTKYFKGNCPNSCKVDGCILTTLEEEDMIRHNWNLP-AHKWKSLLPVTKLIPNQNHLLDSLTLELQDVITHAMITIAPDGGVSRLRLKGFPSSICLLRPLREKPLLRFSLKTGFRANL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8N6M5-1", "uniprot_id": "ALLC_HUMAN", "id": "Q8N6M5-1", "name": "Probable inactive allantoicase", "aln": "----------------------MDMASESVGGKILFATDDFFAPAENLIKSDSPCFKEHEYTEFGKWMDGWETRRKRIPGHDWCVLRLGIQG-VIRGFDVDVSYFTGDYAPRVSIQAANLE-EDKLPEIPERGTRTGAAATPEEFEAIAELKSDDWSYLVPMTELKPGNPASGHNYFLVNSQQRWTHIRLNIFPDGGIARLRVFGTGQKDWTATDPKEPADLVAIAFGGVCVGFSNAKFGHPNNIIGVGGAKSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPG-VITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQKWILP-AHKWKPLLPVTKLSPNQSHLFDSLTLELQDVITHARLTIVPDGGVSRLRLRGFPSSICLLRP-REKPMLKFSVS--FKANP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DGA6-1", "uniprot_id": "ALLC_DANRE", "id": "Q6DGA6-1", "name": "Allantoicase", "aln": "---MAKRQVQKETRSQPHFLQFNNLACETAGGKVIFATDEWFAPARNLLKRDPPEFIASAFTEFGKWMDGWETRRKRIPGHDWCIVQLGVPG-IIHGFDVDTSFFTGNYAPFASIQATCLD---QMPSIALEGDRTGMAASPSQFEAVAQLNSDSWKEVVPVTKLKAGYSDTCHNYLSVSYPHRVTHIRFNIYPDGGIARLKVYGIGKKDWSSVFGQDLVDLVALVNGGVCVGFSDAHYGHPRNMIGLGMAENMGDGWETARRLDRPRVLKEDENGILQVPGSEWAIFRLGHPG-IISKIELDTNHFKGNFPDSCRIEACSLTEDEENSFIQSQWSSDRSPMWNILLPPQKMKAHHRHVFSGPSLVHCGPVSHVRMVIAPDGGISRLRIWG--------RPVSSHQMISKL---------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "P25335-1", "uniprot_id": "ALLC_YEAST", "id": "P25335-1", "name": "Allantoicase", "aln": "MKFFSLADEAEFKSIIISKNKAVDVIGSKLGGQVVSFSDEWFASAENLIQPTAPIRDPTRFVHSGAWYDGWETRRHNEMEYDWVIIKMGVAAAHIIGGEIDTAFFNGNHAPFVSIEALYDE--------GEEGNIVEDDSRWVEIVEKFECGPSQRHLFVRGNGLT---------------KERFTHIKLKMYPDGGIARFRLYGR-VVPPELKTKDHIIDLAYVCNGAVALKYSDQHFGSVDNLLLPGRGHDMSDGWETKRSR--------------QPGHTDWAVIQLGRESSFIEKIIVDTAHFRGNFPQFITVEGCLKESESSENTGEG--------TWVELVGKSKTGPDKEHVY---EIRKSIRVSHVKLTIIPDGGVKRIRVWGY----------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: . **::: :*::*..*.**:: * :.. * * *******:. :** ::::*: . * * ::* ::*.*::** **:* . .* : :: : . . .* . *. .* ***:::::****:**::::* . **. : *.*.: :*: ::* *:: * ..:.***** * :**:::*.: . .* :* :** :*.** *: ::.* ..: . * *: * ..: *: : ::*. :.* ****:.*:*: * ", "identical_positions": 83, "similar_positions": 107, "identity": "19.76%" }, { "cls_id": "homologset.agr.HGNC:17378", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "G3V6D1-1", "uniprot_id": "G3V6D1_RAT", "id": "G3V6D1-1", "name": "", "aln": "MAAPRGPGLFFKPALLGLLGVAWCSLGFGVSRDDDLLLPYPLAR-----RRPSRDCARVHAGSPEQESWPPPPTNPGASHRAAVRTFVSHFEG-----RAVAGHLTRVADPLRTFSVLEPGGPGGCAQRRRATVEDTAVPAGCRVAQNGGFFRMGTGECLGNVVSDGRLVSSSGGLQNAQFGIRRDGTLVTGYLSEEDVLDTVNPFVQLLSGVVWLIRNGSIYINESQITECDETQETGSFSKFVNVMSARTAVGHDRKGQLILFHADGQTEQRGLNLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRRVSTVVCVHEPRCQPPNCSGHGTCVDGRCECTSHFWHGEACSELNCGPSNCSQHGLCTETGCRCDAGWT-------------------------------------------GSNCSEECPLGWYGPGCQRPCQCEHQRPCDPQTGNC----------SISQVKQCLQS------TEAPPRAGGLASFTGTTWLALTLILIFLLLISTAVNVSLLLGSRAERNRHLDGDYVYHPLQEVNGDA----LAAEKEQTEETCNPFKD--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8BJ48-1", "uniprot_id": "NAGPA_MOUSE", "id": "Q8BJ48-1", "name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase", "aln": "MAAPRGPGLFLIPALLGLLGVAWCSLSFGVSRDDDLLLPYPLAR-----RRPSRDCARVRSGSPEQESWPPPPTNPGASHHAAVRTFVSHFEG-----RAVAGHLTRVADPLRTFSVLEPGGAGGCAQKRRATVEDTAVPAGCRIAQNGGFFRMSTGECLGNVVSDGRLVSSSGGLQNAQFGIRRDGTIVTGYLSEEEVLDPVNPFVQLLSGVVWLIRNGNIYINESQAIECDETQETGSFSKFVNVMSARTAVGHDREGQLILFHADGQTEQRGLNLWEMAEFLRQQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCSGHGTCVDGHCECTSHFWRGEACSELDCGPSNCSQHGLCTETGCHCDAGWT-------------------------------------------GSNCSEECPLGWYGPGCQRPCQCEHQCSCDPQTGNC----------SISQVRQCLQP------TEATPRAGELASFTRTTWLALTLTLIFLLLISTGVNVSLFLGSRAERNRHLDGDYVYHPLQEVNGEA----LTAEKEHMEETSNPFKD--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UK23-1", "uniprot_id": "NAGPA_HUMAN", "id": "Q9UK23-1", "name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase", "aln": "MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPYPRAR-----ARLPRDCTRVRAGNREHESWPPPPATPGAGG-LAVRTFVSHFRD-----RAVAGHLTRAVEPLRTFSVLEPGGPGGCAARRRATVEETARAADCRVAQNGGFFRMNSGECLGNVVSDERRVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFVQLLSGVVWLIRNGSIYINESQATECDETQETGSFSKFVNVISARTAIGHDRKGQLVLFHADGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLASYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGHFWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWT-------------------------------------------GSNCSEECPLGWHGPGCQRPCKCEHHCPCDPKTGNC----------SVSRVKQCLQP------PEATLRAGELSFFTRTAWLALTLALAFLLLISTAANLSLLL-SRAERNRRLHGDYAYHPLQEMNGEP----LAAEKEQPGGAHNPFKD--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NEE2-1", "uniprot_id": "A0A8M1NEE2_DANRE", "id": "A0A8M1NEE2-1", "name": "", "aln": "MAKCFVYFDLFFLFLACLGVCLCQCKDIRHSSDDDLLLPYTKSHGPSHSHRYVRDCQPVAHGTVTHETQAASKHSN--SPVLESNIFISDITDDSGTHRWVSGHITEVHDPLRSVSVLEPGGPGGCAHNHRELVEVTAKTRKCLVAQNGGYFDTHTGQCLGNIISDGKLVRNSGGIQNAQFGIRKDGTLVFGYLSEDDILDQENPFVQLISGVVWLLRKGEIYINESIQAECDKTQETGNFRHFVDVISARTAVGHDKEGKLILFHVDGQTDVRGMNLWQVAKFLKDQNVMNAINLDGGGSATYVLNGSLASYPSDHCNPSKWRCPRAISTVLCIHERLCQPEDCSGHGRCVEGQCVCQ-HGWSTPGCANLTC-QAECGEHGICTENGCVCDAGWMGLYCSQVCTAGLYGDGCNQTCTCANGGSCDPVHGRCTCPAGFHGDSCEQECPIGFYGLNCKQLCQCQDMCPCDAATGSCNTTYQGERNISLHRAGHCLATQMWREWRQEEEAQAPRPYLSEQSWLVVCSILATSLLASLTG--NLIQTCRKCKARRQRADYSYLPLGEINGATERGEMKSGKVLFQQGDSDSQDSS", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** :: * : . * ********. :: * *** * *. :*: ... . . . *:*.: . * *:**:*.. :***:.*******.**** .:* ** ** . * :*****:* :*:****::** : * .***:********:***:* *****:::** ******:******:*:*.****** ***:*****.* :**:*:*****:***::*:*:***.****: **:***::*:** .*:*:************:****:*********: . ***** :***:*:** *** :* *** **:*:* * * * .* :* * ::*.:**:***.** ***** *..*.:***:*::* .*:: *:*:. .**. **.* *: :. :** . : . . :: :**.: * ** * .*: .* : *: .** * ** *:** . : : * . :* ", "identical_positions": 244, "similar_positions": 127, "identity": "41.22%" }, { "cls_id": "homologset.agr.HGNC:17379", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7Z5R6-1", "uniprot_id": "AB1IP_HUMAN", "id": "Q7Z5R6-1", "name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------MGESSEDIDQMFSTLLGEMDLLTQSLG----------------VDTLPPPDPNPP----RAEFNYSVGFKDLNESLNALEDQDLDALMADLVAD-----------------------------------ISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEP-------LSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKT--SRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHP---QIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLAS-------------RWTNLGTVNAAAPAQP---STGPKTGTTQPNGQIPQATHSVSA------------------------------------------------------VLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPP-VRRSSDTSGSPATPLKAKGTGGGGLPAPPD------------DFLPPPPPPPPLDDPE--------------LPPPPPDFME--------PPPDFVP-------------------------------------PPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVP---------------------------------------------------PKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS---------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q8R5A3-1", "uniprot_id": "AB1IP_MOUSE", "id": "Q8R5A3-1", "name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "aln": "--------------------------------------------------------------------------------------------------------------------------------MGESNEDIDQMFSTLLGEMDLLTQSLG----------------VDTLPPPDPNPP----REEFNYTVGFKDLNESLNALEDQDLDALMADLVAD-----------------------------------ISEAEQRTIQAQKESSQNQDRFALLRASDGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPEL----LSKEEEEAKAKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNFYLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKT--SRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHP---QIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLAS-------------RWTNLGTVGTPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGP------------------------------------------------------PLQEAQTQIETTKDEKQGLGN-HSPGATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPE------------NFLPPPPPPPPEEDNSGL-----------LPPPPPPPYLE--------EPPDFVP-------------------------------------PPPPP-AAVEDSALPPPPPPPPCLSQEITKSSPLPP----KKPLVP---------------------------------------------------PKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP---------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6PFT9-1", "uniprot_id": "AB1IP_DANRE", "id": "Q6PFT9-1", "name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "aln": "------------------------------------------------------------------------------------------------------------------------------------MDDIDAMFSDMLQEMDLLTQSLD----------------AEVDSAPLAKPPTIPEPQEMNFSIGFANFNESLNDLEDNDLDALMADLVAD-----------------------------------ISATEEKFATERDTS---------------KGSVPVAPAPSKPQSNFSLPASFDSSKPATSSNSIAAPPPPPAFK------PSKEEEEEQLKADKIKLALEKLKEAKVKKLVVKVEITDGSSKTLMVDERQTVRDVMDNLFEKTHCDCNVDWSVCETNPDLQTERAFEDHENLVEPLSTWTRDTENKVLFQEKKHKYEVFKNPQIFYLWKKDKKSLKD----MKEKDKEQLLEENFCGASVIVPDLEGVLYLKEDGKKSWKQRYFLLRASGLYYSPKGKTKA--SRDLVCLVQFDNVNVYYCKEYRIKYKAPTDHCFMLKHP---QIQKESQYIKFMCCDDEWSMNLWVTGIRVAKYGKQLYDNYKAAVRKASGSA-------------SWANRTIQASSTASTP-----SPTPKAKAANGHAPQ--PPVEN------------------------------------------------------KVPSNQSSLPPPPPSMDFLPP--PPPDPMFPPPPPAPPAPPAPPVPVSSTKVNKFPPPPKFPQS---SFPPPPM------------DDLPPPPPPPEIADLPPD-----------FLPPPPPSFVSHGGESLPPPPPDPVAS-----------------------------------LPPPPPAFTSAGGAPPPPPPPPPPPAPAPAVNNPAGS---VRKVAPP---------------------------------------------------PPKRTTPQLAAPSGG---DFMSELMNAMQKKRTQP----------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VWB7-1", "uniprot_id": "Q9VWB7_DROME", "id": "Q9VWB7-1", "name": "", "aln": "MDCGGIAAHQQQQLQQQQLHLLQQQLQQQHHQQQRQQQQHSLEEAATITNINLRGILVGGAASSAGVAGAAAGGATTTTTTTTAAGFVAGGDCPVIGAGAGAGVKLRRHSDRPLTPEAKQLSHTYRISMANLEDSQESELDQILGELSLLEAQISYTEASMLPAMCAPSAGAQIAPPPGVTQLPGSAPTMVSMSASSSRSHSRTNSTISADVSSCSSSGISENGHGLGLVLGGPGSAGMMVQPPPPGGMTMGITLGVVTPREPRTESPDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQQHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAPIRRLFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVDNLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQH-----DEQTRQMLLDEFFD--SHNQLQMDGPLYMKADPKKGWKRYHFVLRSSGLYYFPKEKTKN--TRDLACLNLFHGHNVYTGLGWRKKWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLCLSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTRQLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNGSGTLKRRPIAVPVATVVKQTEPMGSASSTSSSSNSTPTPTPSICAKPPPGDSASLMCSSTLSLDSLPPPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPSSPSTPTPMSTPMIMPNSNGSLPPAVPAKPMKPAVKQAAGGLKAAPPYKAPPDYVGPALLPGPPLPPPPPAQKKVSFADSPVLLRRKMCSPEPVLPQRSPSTTLSCHSSSSAGSAYQTYAPGPMLPPRADVARLSSLSNGSSSEVTSPKRLQESASNPPRDFLKDLQRVMRKKWQVAQKCKAEPATTPHEVLGFRDFSNEDLLAAHNLNSGANSSHYYRETANVSHWVRKHYEYAHNALYENVHAQSAAAAGVPGSGEATTPPLPPPPGNSVAAKKRPPPPPPKRSDKTHLTNRV", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q05683-1", "uniprot_id": "DCE2_RAT", "id": "Q05683-1", "name": "Glutamate decarboxylase 2", "aln": "------------------------------------------------------------------------------------------------------------------------------------------MASPGSGFWSFGSEDGS------------------------------GDPENPGTARAWCQVAQKFTGGIGNKLCALLYGDSEK-------------------------------------PAE-------------------------SGGSVTSRAATRKVACTCDQKPCSCPKGDVNYALLHATDLLPACE------------GERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILTHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGG-----SGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVS-----ATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLN-------------GVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHAS----------------------------------------------------YLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYNIIKNREGYEMVFDGKPQHTN--------VCFWFVPPSLRVLEDNEER--------------------------------------------------------------------------------MSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVIS------------------------------------------------------------NPAATHQDIDFLIEEIERLGQDL-------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . .: . . . : . . . . .: : . . * .. : . . :: .:. * . :: : .. * . :::* :: . : . : . :. :* * .: * :* . :: . . . . : . :* . . : . . : * : * . : . . . : .: * . . : :: :: : . :.. . : . .. .* . . . **. . . . . : . . **: : . : :. ", "identical_positions": 17, "similar_positions": 109, "identity": "1.45%" }, { "cls_id": "homologset.agr.HGNC:1738", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q7TT49-1", "uniprot_id": "MRCKB_RAT", "id": "Q7TT49-1", "name": "Serine/threonine-protein kinase MRCK beta", "aln": "-------------MSAKVRLKKLEQLLLD-----------GPWRNESSLSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD---VSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMIQSNTLTKDEDVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRLERQLEDTVTLRQEHEDSTQRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKRALQEFSELNERMAELRSQKQKVSRQLRDKEEEMEVAMQKIDSMRQDIRKSEKSRKELEARLEDAVAEASKERKLREHSESFSKQMERELETLKVKQG-GRGPGATLEHQQEISKIRSELEKKVLFYEEELVRREASHVLEVKNVKKEVHESESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGAMKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSS-SLGSRTLDP-LWKVRRSQKLDMSARLELQSALEAEIRAKQLVHEELRKVKDTSLAFESKLKESEAKNRELLEEMQSLKKRMEEK-----FRADTGLKLPDFQDPIFEYFNTAPLAHDLTFR-----------------TSSASDQETQASKLDLSPS---------VSVATSTEQQEDAARSQQRPSTVPLPNTQALAMAGPK-----PKAHQFSIKSFPSPTQCSHCTSLMVGLIRQGYACEVCAFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFAVSSVLASDVIHATRRDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLRSQVVHVAQEAYDSSLPLIKTVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKLILLLCGRNHHVHLYPWTSFDGAEASNFDIKLPETKGCQLIATGTLR--KSSSTCLFVAVKR-----LVLCYEIQRTKPFHRKFNEIVAPGHVQWMAMFKDR-LCVGYPSGFSLLSIQGDGQPLDLVNPADPSLAFLSQQSFDALCAVELKS------EEYLLCFSHMGLYVDPQGRRSRTQELMWPAAPVACSCSSSHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSDGSLNLLGCEPPRLIYFKNKFS-GTVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAAPTA-------------------------------QEE-------------KQGPAPTGLPR---------------------QLPSRNKPYVSWPSSGGSEPGVPVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLDQPACDA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q7TT50-1", "uniprot_id": "MRCKB_MOUSE", "id": "Q7TT50-1", "name": "Serine/threonine-protein kinase MRCK beta", "aln": "-------------MSAKVRLKKLEQLLLD-----------GPWRNDSALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD---VSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDMLRNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMTQSNTLTKDEDVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRLERQLEDTVTLRQEHEDSTHRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKRALQEFSELNERMSELRSLKQKVSRQLRDKEEEMEVAMQKIDSMRQDLRKSEKSRKELEARLEDAAAEASKERKLREHSESFCKQMERELEALKVKQG-GRGPGAASEHQQEISKIRSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGTVKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSS-SLGSRTLDP-LWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDSSLAFESKLKESEAKNRELLEEMQSLRKRMEEK-----FRADTGLKLPDFQDSIFEYFNTAPLAHDLTFR-----------------TSSASDQETQASKMDLSPS---------VSVATSTEQQEDMARPQQRPSPVPLPSTQALAMAGPK-----PKAHQFSIKSFPSPTQCSHCTSLMVGLIRQGYACEVCAFSCHVSCKDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVVASQVLDLRDEEFAVSSVLASDVIHATRRDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLKSQVVHVAQEAYDSSLPLIKAVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIELAPKEKIAILLCGRNHHVHLYPWSSFDGAEASNFDIKLPETKGCQLIATGTLR--KSSSTCLFVAVKR-----LILCYEIQRTKPFHRKFSELVAPGHVQWMAVFKDR-LCVGYPSGFSLLSIQGDGPPLDLVNPTDPSLAFLSQQSFDALCAVELKS------EEYLLCFSHMGLYVDPQGRRSRMQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSDGSLNLLGCEPPRLIYFKNKFS-GTILNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAAPTV-------------------------------QEE-------------KQGPTPAGLPR---------------------QPPSRSKPYVSWPSSGGSEPGVPVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPMEGLDQPSCDA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y5S2-1", "uniprot_id": "MRCKB_HUMAN", "id": "Q9Y5S2-1", "name": "Serine/threonine-protein kinase MRCK beta", "aln": "-------------MSAKVRLKKLEQLLLD-----------GPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD---VSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQG-GRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSS-SLGSRTLDP-LWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEK-----FRADTGLKLPDFQDSIFEYFNTAPLAHDLTFR-----------------TSSASEQETQAPKPEASPS---------MSVAAS-EQQEDMARPPQRPSAVPLPTTQALALAGPK-----PKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGS-FDIKLPETKGCQLMATATLK--RNSGTCLFVAVKR-----LILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDR-LCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELES------EEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFS-GAVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPS-------------------------------QEE-------------RPGPAPTNLAR---------------------QPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLEQPACDT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P2Q2-1", "uniprot_id": "A0A8M9P2Q2_DANRE", "id": "A0A8M9P2Q2-1", "name": "non-specific serine/threonine protein kinase", "aln": "-------------MSAKVRLKKLEQLLLD-----------GHQKNDKSLSVETLLDILICLYNECSNSPLKREKHVTDFLEWVKPFTTTVKEMRLHRDDFEMLKVIGRGAFGEVAVVKMKHTERVYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQRYVHRDIKPDNVLLDMNGHIRLADFGSCLKMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITD---VSEDAKDLIQRLICSRERRLGQHGIEEFRKHAFFSGIDWENIRNMEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPVSHTGFTGQHLPFVGFTYTTESCFSDGGSMRGVALSDGGTG-EDLQ---DGGMQVEAFEKRIRCLEQEKLELNRKLQESTQAVQSLHGSGRGAGTLGRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTLRQDFESSSTKLKALDKQVKALKLEKEDIHKQLVESLDRLKSQTKELKDAHQQRKLAMQEFSEVNERMAELRSQKQRLSRQLRDKEEEMEVVMQKIDAMRQDIRKTEKARKELESQLEDARAEASKERKLREHSEVYSKQLESELETLKVKQGTGRASGLGAETQQELTKLKSELDKKGLYYEEELVRREASHTTEMKNLRKELQDSEGQQLSLHKELLALKEKLEKAKRERQIEMEEAINALKEQYERERNLMSEDNRKLTAETDRLCSFVDKLTAQNRQLEDELQELASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELESLRSS-SLGSRTLDP-LWKVRRSQKLDMSARLELQSALEAEIRAKQLVHDELRKVKAANISFESKLKDTEAKNRELEEQLENMKKEMEESR----SRSDKGLKLPDFQDSIFDYFNTSPLAHELTFRDSVSSSSASSLLAFWDETSSVGDVDVAPQKTDIPPS---------SPSAAT--EQDEAVKPQATTPATPSPMYQP-TLTAPK-----PKAHQLSIKTFSSPTQCTHCTSLMVGQMRQGYACEVCSFICHVSCKDNAPQLCPIPPEQTKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKSTQPVVMASQVLDLRDEEFSVSSVLASDVIHANHKDVPCIFRVTSSALKSSIRPVPLLILAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDSSLPAIKTTLSAAIVDRERIVLGTEDGLFVVEITRDVIVRAADCKKVCQIELIPKEKMVALLSGRNRHVHLYPWAALEGAEGG-FDTKLTDTRGCQAMTIGNLR--PGGPACLFAGVKR-----QVFCYEITRAKPHHRKLWEVQAPGVVQWLGIIRER-ICVGYPSGFALLAMQGESSPVSLVSPGDPSLAFLAQQPLDALHAMEVGS------NELLLCFSQLGVYVDATGRRSRTQELMWPSTPLACSSNSNCLTVYSDYGVDVFDVHTMEWVQTISLRKIRPLNVEGSLNLLSIEQPHLIYFSNNSSDGCDLAIPETSDNSKKLMVRTRSKRKFLFKVPEEERLQQRREMLRDPEMRSKLISHPTNFNHVAHMGPGDGMQVLMDLPLPSETPSPSSSRHHALISPPTNFEHVYHMSPVSAGLYLQKEPSSQQSLLQFSSSSSSPSTSSLGRSVMPSSQDDLSKDKPRPLSSISRQQRSKTHITRTASGGGDFGGAGSSRSISDQDQDYEREPDSDSTKHSTPSNSSNPSSPPSPNSPHRSQLTLDSLDQSLDG-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W1B0-1", "uniprot_id": "GEK_DROME", "id": "Q9W1B0-1", "name": "Serine/threonine-protein kinase Genghis Khan", "aln": "MEYESSEISDITTGSCKKRLTFLKCILSDTTSDQKWAAEFGEDTEGHQFSLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFS---------------------------------------------------------LTSSSTLDSKKNQSSGFG-----------DDTLDTISS---------PQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELR----KGSSSVETTMPLSISSEMS--SYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED---DEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDS-----------------AESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPTTCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGG-LSLNTLMLADNESEKSKWVIALGELHRILKRNSLPNTAIFKVNEILDNTLSLIRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVE--WIKVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIH---TKGLLQYRDGNRKGLP--SIKRRFSIREINKTIKSDR---------RSKMISAPTNFNHISHMGPGDGIQNQRLLDLPTTLET--------------------------------------------------------------------------------------------ADQACSPIIHSLSCIPQSRKSNFLEQVDANSDDYG---NDNIISRTPSPMASS----FMDGLSNND---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.* **. *: :* * * : :*:: *** :: ** ***:*.*:*:* *::**: ***. *:.::* *:**:::*:*********.**:* **::************************:*** ** **** *******: ******** *************:******:**: **:***.**** :************** .**:*********:: .******.**************:***** *:**.************************************:: *::**: * *** ::**: :*** *.****:**::* .*.:* *::*:***: ***:*:****:*********: :: : ** ::..*:* ****:***:: *:.:::* :.. . . :: :: :.. ** : ..: .: :*:.*:.* : ** :: ** * :***:* .**:** .**: *: *:**:.*:::*** **::***:******:: . ** *::*:::*:::* *:*** :::** **:**:*****:* .:*:: **. * . . . . ..*:: *::: * :.*:* :::: * *:: ::::. : *. :*:* **: :::*: :: * : *:: :*.::: *: :::::*::* : .. :.:* *:: :: :::* *:*::: ** *:*********************:******* *: ::... :* *: ******* *:*****: **:**::: :** :.: :: :.:::: : : .: .::: ...:.: ::. *: . .:. :*. . :: :.* .: . . : * . : :::. . . : . . * . **: :::*.***:*.******** *** .**:*.* **. * : .* **:* :*:*****:* *******:*.*::**. :*:** * :.**** *****::. .:.: * * .*****:** **:*.** ****** ::*:****::.:: : . . *:*::.* ** *** * *: ** :* * . .:. * *.:*. *: * :.*: ::* :* *:**: ::: : *.* .:.**: *: .*:: :*.*::::::* * :::.:: *: :::.* . :: . .:: .:** :. *** *::. *:* *. .* : :: : : *.: *** ::*:. .:.** * : *** . .**: .:*: . * ** *. :.:*** **::* :*:*:*: * : : *:*: :*:*:.:* ****:*.*:: *** *.: * . : . ** : .: : : *..:* : **:* :: :: .:* ***:** ******::*******:* * *.: :. . . .. ..:: .: *::* .:. *.. * .*** :. ::.*.: ", "identical_positions": 631, "similar_positions": 514, "identity": "33.94%" }, { "cls_id": "homologset.agr.HGNC:17380", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZIT4-1", "uniprot_id": "D3ZIT4_RAT", "id": "D3ZIT4-1", "name": "Anaphase-promoting complex subunit 7", "aln": "MMGQPLSPHDCLFLRRHIRSNLYLRGAEPRLDQKDPAAAAILELSLRLGSAPGGSVSCCWVTVSPGRMSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRP-STGNSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQE-----RPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREG----RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLAT--VCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVSVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEGS---------------------------PTDATQEDDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WVM3-1", "uniprot_id": "APC7_MOUSE", "id": "Q9WVM3-1", "name": "Anaphase-promoting complex subunit 7", "aln": "-------------------------------------------------------------------MSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYAMALQQKKALSKTSKVRP-STGNSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAVLDGIPSRQRTPKINMMLANLYKKAGQE-----RPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDSKNSVLKFEQAQMLDPYLIRGMDVYGYLLAREG----RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLAT--VCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEES---------------------------PTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UJX3-1", "uniprot_id": "APC7_HUMAN", "id": "Q9UJX3-1", "name": "Anaphase-promoting complex subunit 7", "aln": "-------------------------------------------------------------------MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRP-STGNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQE-----RPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREG----RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLAT--VCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEES---------------------------PTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A9C3Q3-1", "uniprot_id": "A9C3Q3_DANRE", "id": "A9C3Q3-1", "name": "", "aln": "-------------------------------------------------------------------MNVIDHVRDMAAAGLHSNVRIISSLLLTMSTNNPELFSPSQKYQLLVYHADAIFHDKEYRNAACKYNMALQQKKMLSKTSKVRPSSTGSTTSAVQAQNLPSEIEVKYKIAECYTILKLDKDAISVLDGIPSRQRTPKINMMLANLYRKAGQE-----RSAVTSYKEVLRQCPLALDAIIGLLSLSVKGAEVASMTMDVIQSIPNLDWLSVWIKAHAFIHGGDNQRAINTICSLEKKSLLRDNVDLLVTLADVYFRAGDTKNSILKFEQAQMLDPYLIKGMDVYGYLMAREG----HLEDVEVLGGRLFNISDQHAEPWVISGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGVALRNMGRVQEAIIHFREAMRLAPCRLDCYEGLIDCYLASNGIREAMGMANNIYKTLGANAQTLTILAT--VCLEDPMTQEKAKTLLDKALAQRPDYIKAVVKKAELLSREQKYEEGIALLRNTLANQSDCVLHRMLGDFLVAVNDYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEES---------------------------PTDATVELDGDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W3Y6-1", "uniprot_id": "Q9W3Y6_DROME", "id": "Q9W3Y6-1", "name": "", "aln": "-------------------------------------------------------MASFLIVVEKMEIALFANAKKLYDHKLYECVIPAADLLRTVLKNDRYVATLDVEYQVLLYLLNANYKERNYRAALRHFDEIIHKRRLMMRHKNAVLVAIESSYPEFG------DAEQRRRAAECYRQIGNTDMAIETLLQVPPTLRSPRINLMLARLQHHGSRHGTTKKSEAVLAYKEVIRECPMALQVIEALLELGVNGNEINSLVMHAATVPDHFDWLSKWIKALAQMFNFKHSDASQTFLMLHDNTTLRCNEHLMMALGKCLYYNGDYFQAEDIFSSTLCANPDNVEAIGLMAVLCGQEGGCEQDSADMDYLFAKVSSEVKYTASHWFAHAQLLYDEGKFERGLNFVEKCLDSEPRNHEALILRGRLLIALERHTQAVCAFRTAQMVAPYRFEIYRGLFHSYLAQKRFKEANALCNWTIRLFQNSPRSFTMFGRTLFLFPDPRMRRTARKFAEKSLKINHIYTPAVNLIADICQVEGPTKAIIKLLEKHVIIFPKVNLLNHLGDIMRKQKEPVKAMEYYYKALRQDPKSKRTLRGLRLLAKSDDESPVLDESDDIGMDNQQSINDLTTLCEATNAQGAEGAESVENSREASSSAAARSGQEEDVDEHDWIDVPDGMSY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: :.:.: *:. * :.** *: .*: : : :**:*:* :: :::::** * :: ::::: : : .:. : .: . : * : : **** : . ** * :*. *:*:**:***.* ::..:. :* :****:*:**:**:.* .**.*.*:* *: *:.*.. ::**** **** * :. .:. * .*: *..:: ** * .*: :*.. : ** :: *..: :* :..:.: . * .:** *:: * :: . . *. *. . : . ::.*.* : *.:: :... :**:*:* * : * :*: ** * :** *:: *.**:..***.: ::** :.* : : ..:::*::. . : ** :..*:.: :*:* . * ** *:: . * : * **.: : .. * . ***:: :: :**: * ** **:.:::*.*:: : *. . .*:* . :.:*.* * .. .: * : .*:.:*:.: ", "identical_positions": 138, "similar_positions": 219, "identity": "20.41%" }, { "cls_id": "homologset.agr.HGNC:17381", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z200-1", "uniprot_id": "SH2B2_RAT", "id": "Q9Z200-1", "name": "SH2B adapter protein 2", "aln": "----MNGATPGSAAAP-----APVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTP--DAGTSFSRHFAANFLAVFSEEVRRVLGT------AADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQ-REGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEA-DMPRPPETMTAVG----------------------AVVTAPHGRARDTVGESLAHVPLETFLQTLESSGG-VSESNNTGDEGAELDP-DAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATS------------------------------------------------VPPRPAEGPLSARSRSNSTEHLLEAASG-ATEEP--------------------ADATLGRARAVENQYSFY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JID9-1", "uniprot_id": "SH2B2_MOUSE", "id": "Q9JID9-1", "name": "SH2B adapter protein 2", "aln": "----MNGATPSSAAAP-----APVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTP--DAGTSFSRHFAANFLAVFSEEVRRVLGS------AADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEPASEPRDKWTRRLRLARTLAAKVELVDIQ-REGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDA-DMPRPPETTTAVG----------------------AVVTAPHGRARDTVGESLAHVPLETFLQTLESSGG-VSENNNPGDEGAELDT-DAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPSNGAGASSSSGSSSSATS------------------------------------------------LPPRPAEGPLSAHSRSNSTEHLLDAASG-ATEEP--------------------TEATLGRARAVENQYSFY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O14492-1", "uniprot_id": "SH2B2_HUMAN", "id": "O14492-1", "name": "SH2B adapter protein 2", "aln": "----MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTP--DAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAE----PRDKWTRRLRLSRTLAAKVELVDIQ-REGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPE-TTAVG----------------------AVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDP-EAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASG----------------------------------------------PAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEP--------------------PEAAPGRARAVENQYSFY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0B4LHY5-1", "uniprot_id": "A0A0B4LHY5_DROME", "id": "A0A0B4LHY5-1", "name": "", "aln": "MGGNSTGANTSAFSAGGYIGPTSASSHHSLGTSSAAAAAAAGSDLIPAPIGTGNAMGVSSYAYGGTSWEEFCERHARVAASDFAKACITYIN---GNLPPEEARNIQHRSFAQKFVESFSAHYDTEFFKRRSTLKSGAGSLDFEEEHEVPKLLSKSLLRRLSFKGLRKGKISLLQAFFHKNSDDLDGSGGSGKQSKTKLAKIVVECRKEGTVNNLTPESLDQPTGSQKWEKCRLVLVKAVG--GYMLEFYTPHKATKPRSGVFCFLISEARETTALEMPDRLNTFVLKADNNMEYVIEAESAEEMRSWLATIRYCMRTPPTQQPTIESDGVMASAMQTSPTLPSPNPIGGIQNPQYQQQRGSNGNLVGGGAPLTSSLSADSALGQGGATSASELNVINELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHLWFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPTTAANHDSGQLNDLSTNGNGNGNGNGYDNGQGSSTASNAAGGTASGAAGGGHPSPRHCNEVITMNLSVRLKTNEIELPQEPTHVYFPEQVYFHLDPTTLTVHGSPPPAQNFLDQPHLRASNASLQAAAHHQAGSSGNRHPSDGGSNSGGAGGGSGSSGGAECTGRAVDNQYSFT", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .** ... :* ..... :.: * .**. :. : : . : ... * : ..*. .. * ..:. :. : . . * : * * . :: . :. : :* .:.:.: :.: :* : . . *. .: :*: : :: *: . :: :: . *: :*:****:* :**. : ***:.* **::*: .: * *.* * .****:: ******.:*. **::*: .: : :**:* *: *: . ::: * * .. . .: .. . : *: : : * ...:*.. . : : * * : ::. .. :..* * :*:* *. *: *:* :*******:* :**::** ... .** *::****** ** ********:******::. :***:****** *: :**.**: :********::*:** .:*:::. :* .:. . : . : .. .::.*:.**.::*..:... .* .* *.:. *. * * *. * .. . .: .***:***** ", "identical_positions": 155, "similar_positions": 216, "identity": "21.15%" }, { "cls_id": "homologset.agr.HGNC:17382", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M287-1", "uniprot_id": "F1M287_RAT", "id": "F1M287-1", "name": "SLIT-ROBO Rho GTPase-activating protein 1", "aln": "---MSTP-SRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQMGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSSLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIHKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVPEDKSSSKDMNSPTD-RHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLTGH-PRGLLQNRG-LNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFND--HKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHSVTLR--SSEPQLRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAV-LPKTNPTVGPAAPSQGPTDKSCTM", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91Z69-1", "uniprot_id": "SRGP1_MOUSE", "id": "Q91Z69-1", "name": "SLIT-ROBO Rho GTPase-activating protein 1", "aln": "---MSTP-SRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTS--------RGRRNSHARHQ---------------DSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLSDEQSNHDINSVAGVLKLYFRGLENPLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTD-RHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLASH-PRGLLQNRG-LNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFND--HKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALR--GSEPQIRRSTSSSSETMSTFKPMVAPRMGVQLKPPALRPKPAV-LPKTNPTMGPAAPSQGPTDKSCTM", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7Z6B7-1", "uniprot_id": "SRGP1_HUMAN", "id": "Q7Z6B7-1", "name": "SLIT-ROBO Rho GTPase-activating protein 1", "aln": "---MSTP-SRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTD-RHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASH-PRGLLQNRG-LNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFND--HKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALR--SSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAV-LPKTNPTIGPAPPPQGPTDKSCTM", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M6Z228-1", "uniprot_id": "A0A8M6Z228_DANRE", "id": "A0A8M6Z228-1", "name": "SLIT-ROBO Rho GTPase-activating protein 1", "aln": "MLKMSNPPVKFKKDKEIIVEYETQVKEIRAQLVEQQKCLEQQTDMRVQLLQDLQDFFRKKSEIEMEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRLMKKSKEITFQLQEDLMKVLNELYTVMKTYHMYHTESISAEGKLKEAEKQEEKQIGRVGDPVFHIRLEDRHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASIFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDSLDPRSDRQRFMEMYPTAFCPPVKFEFQAHMGDEVCQITAQPPVQAELLLRFQQLQSRLTTLKIENEEIKKTSEATLTTIQDMVTVEDYDVSECFHHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKFREYLEGSNLITKLQAKHDLLKRTLGDGYRPEYATTRPPSLPPKPFGTQRARPRSVFNVKLFNGNLESFVKDSGQAIPRVVESCIRFINLYGLQHQGIFRVPGSQVEVNDIKNSFERGNDPLTDEENNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIENLYERALYIRKILLTAPRSVLVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPTPETQDQVSCQAHVNEVIKTIIIHHETIFPDSKELDGPLYEKCMAGGDYCESPYSEHGALEEVDQDGGAETHTSEDEGEPIEAIAKFDYVGRSARELSFKKGASLLLYQRASDDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGHGGEEKCSSRDMGSPTDSRLPDAYISRHRKRSDPPTR-RPPARPTDTHCLVHPSHHSSHTNPDLGSPVMGHYSPRDMLRGRGHMPMDSPERRRRTGHGSLTNISRHESIKKMESPPIRRSTSSGQYSSFNEPHVKSLDPESIAQDIEETMNTALNELKELERQSSAKHAPDVVLDTLEQMKNAPTPASSTESLSQLHGLLLRPAGTELHMRRSTSSSSDTMSTFKPAVAPRMGVQLKPPTLRPKPMVPVPKTGAAQHPAAPPQDPLDKSCTM", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " **.* :********.***:********************:****************:*** *************************:***************************************************::******:***:*********************:******.************:** **********:**********************************************:*****************************************************.*:****:********:*****:*****:********::** ******:** *******:*****.**:***:**** *******:*********:***************************************:**:****.************:****:*:*.** ** :.::.* ****.** :*********************.****************::**:*::.****************************.********:*******:*:*:*** *****:************************************.** ************::*************:******:*******.***:*******:*******.*:*.****** ******************************:***:******************************************* *:*.**:**.**** * .*.*::*:***.:**. * *.*.:* ** :**.* *::. ***** : : **.:*:.** : ********.***********:*:**::*************:.**: *.****:****************:******:.*************:**:****:****** **.: ** .:* ::********:******* ************:***** * :***..: **.*.*.* ******", "identical_positions": 890, "similar_positions": 129, "identity": "81.13%" }, { "cls_id": "homologset.agr.HGNC:17383", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91ZY1-1", "uniprot_id": "HRH4_RAT", "id": "Q91ZY1-1", "name": "Histamine H4 receptor", "aln": "--MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFN-WNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQT-QSVSS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91ZY2-1", "uniprot_id": "HRH4_MOUSE", "id": "Q91ZY2-1", "name": "Histamine H4 receptor", "aln": "--MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFN-WNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQN-QSVSS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H3N8-1", "uniprot_id": "HRH4_HUMAN", "id": "Q9H3N8-1", "name": "Histamine H4 receptor", "aln": "--MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEG--SECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NCA8-1", "uniprot_id": "A0A8M1NCA8_DANRE", "id": "A0A8M1NCA8-1", "name": "", "aln": "MCEDYSCPERSVSLSVYVILYVAAAAVALLTVCGNLLVIISVSHFKQLHTPANILILSLAASDLLVGVFVMPLLFTLLIESCWIAGPVMCAVLKFVNFQATSVSVHTVSLIAVDRFLALSFPFFYSEKIS-LTVICIAALSNWLFSLFYNFTVLYINRHFTGFMCPGVCF--FVIDEVSSLIDLLIVFVMPCTLIIILYTHVFVIAKKHATAIRALQVHNSTESSKNKISDKS---------------------------------------------------------------------ERKAAMLLGILVFVFLLCLLPYYITSLVISYTTVD---LLHVRDVAVIFFFVNSTINPIIYALFYPWFQKCLKLIFTLKVFERDSSLMNVQCY", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :. :. * * . : .*: ** :**::. ::*: :. ::*.** **::**:: :** :. : . * * :* . .:: :.**:.: **: **: ::* .. * : : : * :: *::::: * .:: . :.. * *. : * :: *::* : : ::: *: *. . . *. .. *: * *.:*: .* :* ** : ::*:* :*. : :.** :**::*.* : ***.: *: :. *. . . ", "identical_positions": 61, "similar_positions": 109, "identity": "15.44%" }, { "cls_id": "homologset.agr.HGNC:17384", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LIG8-1", "uniprot_id": "A0ABK0LIG8_RAT", "id": "A0ABK0LIG8-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MTAGLGWRGVAHCVPATVRPRTHPQPLGREWVRGLLPVAAARQQDGGSGPRSGGDNGVRKVTPAGAGSRPVRAGTRSPRSRRQARLILCGVGWPSLKFPMTQWTPEYNELYTLKVAMKSGTPPDAPTTQESLKAVLLHPQPLGATKSFPAEVEMINSKVGNEFS-HLCDDSQKQEKDMNDNQQEQEKSGVVRKKRKSQQAGPSYVQN-CVKENQEILGLRQH----LATPSDEDD--DSSFSECLSSPSSSLHFGDSDTVTSDED-KEVSVRHSQPILSAKS-------------------RSHNARSHKWPRTEAEPVPGLLMKRPCFHGSAVRRVPCRKRPVKSSS---SQRTQKQKERLLVQRKK---LAQRKYALLASSSTSSENDLSSDSSSSSSTDGEEDLCASASENP---SNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHTGRAQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMDSQTTSASINNSNPSTSEQGSDTTSTVASSQPSTVSETAATLTSNSATGSSVGDDVRRTAS------NAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQ--------------QHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERP-QVQAPCGANSSSGSSYHDQQALPVDLSNSALRTHGSG--GFHGASAFDPCCPVSSSRAAVFGHQAAAAP-TQPLS-IDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRALHHQAS-ACHHSHGSAPPQTQPPPQVDYVIPHPVHAFHSQISTHAASHPVAPPPP-----THLGSTAAPIPQHLPPAHQPISHHIPAPAP-SAQRLHPHEVMQRMEVQRRRLMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKK-----------------------------RKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99ML9-1", "uniprot_id": "RN111_MOUSE", "id": "Q99ML9-1", "name": "E3 ubiquitin-protein ligase Arkadia", "aln": "---------------------------------------------------------------------------------------------------MSQWTPEFNELYTLKVAMKSGTP-DAPTTQESLKAVLLHPQPLGATKSFPAEVEMINSKVGNEFS-HLCDDSQKQEKDMTGNQQEQEKSGVVRKKRKSQQAGPSYVQN-CVKENQEILGRRQQ----LETPSDEDN--DSSLSECLSSPSSSLHFGGSDTVTSDED-KEVSVRHTQPVLSAKS-------------------RSHSARSHKWPRTEADPVPSLLMKRPCFHGSALRRVTCRKRLVKSSS---SQRTQKQKERMLVQRKKREALAQRKYALLSSSSSSSENDLSSDSSSSSSTDGEEDLCASASENP---SNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHTGRPQESRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTIVPTTSARMDSQTTSASINNSNPSTSEQASDTTSTVASSQPSTVSETEATLTSNSATGSSVGDDVRRTAS------SAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQ--------------QHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERP-QVQAPCGANSSSGSSYHDQQALPVDLSNSALRTHGSG--GFHGASAFDPCCPVTSSRAAVFGHQAAAAP-TQPLS-IDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRPLHHQAS-ACHHSHGNAPPQTQPPPQVDYVIPHPVHAFHSQISSHAASHPVAPPPP-----THLGSTAAPIPQHLPPAHQPISHHIPAPAP-SAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGASFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTD---------------------WFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6ZNA4-1", "uniprot_id": "RN111_HUMAN", "id": "Q6ZNA4-1", "name": "E3 ubiquitin-protein ligase Arkadia", "aln": "---------------------------------------------------------------------------------------------------MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFS-HLCDDSQKQEKEMNGNQQEQEKSLVVRKKRKSQQAGPSYVQN-CVKENQGILGLRQH----LGTPSDEDN--DSSFSDCLSSPSSSLHFGDSDTVTSDED-KEVSVRHSQTILNAKS-------------------RSHSARSHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNS---SQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSASENHQ--NNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTTGTSIGDDSRRTTS------SAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQ--------------QHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERPPQVQAPCGANSSSGTSYHEQQALPVDLSNSGIRSHGSG--SFHGASAFDPCCPVSSSRAAIFGHQAAAAAPSQPLSSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRPLHHQAS-ACPHSHGNPPPQTQPPPQVDYVIPHPVHAFHSQISSHATSHPVAPPPP-----THLASTAAPIPQHLPPTHQPISHHIPATAP-PAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERSAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTD---------------------WFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BG80-1", "uniprot_id": "A0A8M2BG80_DANRE", "id": "A0A8M2BG80-1", "name": "RING-type E3 ubiquitin transferase", "aln": "--------------------------------------------------------------------------------------------------------------------MKSEISADARRKQEPLKGPLANPEPMETAKSFPAEMEVIG-KAGSDFTSPLCAETRHRPSRDAGGRRDCDRGLSGRKKRKSQQPGPSYCSLKEAPMSEATLTPPRHRPMLLETRSEDERNPESSLSDCASSPSSSLRFGDSDTLSSDEDGMPMTVRQQLKAHGAASTGSTGSSTGTAVGIRPLLARTRASRSHKWARLEPDSN---HVKRPCLGS---RRPLHRKRFVKGGAGGVTQRTPKQKERLLLQRKKREVIARKKYALLHSTSSSSE-EMTSDDSSPSSTEAEHELYVDVNSSSSQASTAAVASGVLDEDVVVIEATPAPAVPASEEINVTSTDSEVEIVTVGDAFRPRSVGGHGRMHWG--PSCSQSRAQEGRGRHRLSTVIQPLRQSAGEVVDLTVDEDDLSVVPTTSDSTHPQPVSSSSSSSSRNACTSASPQEGPGPSS-SCSAAAPDSTLAAQSHGGVPRSGTTNTTATEDESRRSLLGENGGVAMPRLPSCCPQHSPCSGPSSGHLSMGHTHSGCMQSGATQQSGPPQPGSQHSHTHSHHFHHHHHTAP-VPSSLAYQESSCPLERPTAMPAPCGGVSN---QYHDQQTLPVDLSSSAVRSSGSSSTGFHGTSAFDPCCPGSASRPPVYVSQAAPGPSQQTVA--DSFSPTIVAQPQPQPP---QLSSCRHYMHPTYGSLSRPLHHQSSSSCPHSHSNAPPPQQPPPQGDYVIPHPVLPFHTPLPTHAPGHTVPTAPPPSLPSHHLPGSSAPLPQHLPPEHQALQHHLPVLGPNSVQRLHHHDLLQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSLPRQSDQRTTWELGIEAGVTVAPYPSGHLHPHLPHYHPPPRLHHFPIQLMHTGSMPEVTYPHIRYISS-------RMTFGRTYEDLLHLEERLGTVNRGASQGTIERCTYPHKYKKKVVERDTEEQLAPEAWASVGKKMHSTSNSRKLHGKQEEEEGAEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQLCVDQWLLTNKKCPICRVDIEAQLSSES", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *** . ** .**.**. * :*:*: ::***** :*:*. *.*.:*: ** ::::: . ..::: ::. ********.**** . . .: * :: * * *::: :**:*:* *******:**.***::**** ::**: .* * *:: :*****.* *.:. :****: . ** *** **..: :*** *****:*:**** :*::***** *:*:*** :::*:.**.***:.*.:* ...... ...*..** :*********: :* *.*.******************:::*.**. **.* **. .*. .*.** *.* *:*********.*.**********: ::***** ..*..*:* ..*. .:. ..* .. .** ..:.: . :**:::* * . .. . *:: . : *.* ***************.*.*..* ::.*.*:.*:* **.* ..**.**** . * ** * ::.:.:**:*** : ****. *. .**:**:******.*.:*: **. .***:******** ::**..:: ***... *.:: *.:..::********* .******** *.*.**:*.****:* :* ***...** ***** ******** .**: :.:**..*.*...** ** .::**:****** **.:.**:*. .* ..**** *:::*********:************************************ ***: :*::**********.*.*..* *****.***.******: : : . ********* * .* .:*:*:*******.********************* **** **: ***:********************************:******:****************.***", "identical_positions": 537, "similar_positions": 267, "identity": "45.66%" }, { "cls_id": "homologset.agr.HGNC:17389", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P70158-1", "uniprot_id": "ASM3A_MOUSE", "id": "P70158-1", "name": "Cyclic GMP-AMP phosphodiesterase SMPDL3A", "aln": "----------------------MALLG-NFLCCLLVAWLCGPGLGVPLAPADR-------------------------------------APAVGQFWHVTDLHLDPTYHITDDRTKVCASSK---------GANASNPGPFGDVL--CDSPYQLILSAFDFIKN-SGQEASFMIWTGDSPPH--VPVPELSTGTVIKVITNMTMTVQNLFPN----------LQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNPGLRIISLNTNLYYG--------------------------PNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVG-----------------------------YLPYATDTPAIRQYYNEKLLDIFRRYSSVIAG-------------QFYGHTHRDSLMVLSDKNG-------NPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTEANLK-------GESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNLDSMSYDDCLKQHL----------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q641Z7-1", "uniprot_id": "ASM3A_RAT", "id": "Q641Z7-1", "name": "Cyclic GMP-AMP phosphodiesterase SMPDL3A", "aln": "----------------------MALPG-NFLCCLLVAWLCDPGLGVPLAPAYG-------------------------------------APAVGQFWHVTDLHLDPTYHITDDHTKVCASSK---------GANVSNPGPFGDVL--CDSPYQLILSAFDFIKN-SGQEASFMIWTGDSPPH--VPVRELSTGSVIEVITNMTVTVQNLFPN----------LQVFPALGNHDYWPQDQLPIATSKVYSAVSDLWKPWLDEEAISTLRKGGFYSQKVASNPDLRIISLNTNLYYG--------------------------PNIMTLNKTDPANQFEWLENTLNSSLRNKEKVYVIAHVPVG-----------------------------YLPYATKTPAMRQYYNEKLVDIFRRYSSVIAG-------------QFYGHTHRDSLMVLSDKNG-------NPINSVFVAPAVTPVKGVLEKETNNPGVRLFQYKPGDYTLLDMLQYYLNLTEANLK-------GESNWTLEYTLTQAYGVADLQPKSLHGLAQQLATIDSKQFLKYYHYFFVSYDSSAPCDQRCKTLQICAIMNLDLVSYEDCLKRHL----------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q92484-1", "uniprot_id": "ASM3A_HUMAN", "id": "Q92484-1", "name": "Cyclic GMP-AMP phosphodiesterase SMPDL3A", "aln": "----------------------MALVR-ALVCCLLTAWHCRSGLGLPVAPAGGR----------------------------------NPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSK---------GANASNPGPFGDVL--CDSPYQLILSAFDFIKN-SGQEASFMIWTGDSPPH--VPVPELSTDTVINVITNMTTTIQSLFPN----------LQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYG--------------------------PNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVG-----------------------------YLPSSQNITAMREYYNEKLIDIFQKYSDVIAG-------------QFYGHTHRDSIMVLSDKKG-------SPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLK-------GESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIKHNY-----------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M2BHJ3-1", "uniprot_id": "A0A8M2BHJ3_DANRE", "id": "A0A8M2BHJ3-1", "name": "Acid sphingomyelinase-like phosphodiesterase", "aln": "----------------------MALFVLLFLFCHVFNLQVSS---APVSNVFK------------------------------------HLQTASKFWHISDLHLDPTYHVTEDHTKVCFSSK---------GVPALDPGVFGDFL--CDSPYQLILSAFSYMKQ-VDLQPEFIIWTGDSPPH--VPKEELSTDVVINVIANMTRTIQQFFPQ----------IPVYPALGNHDYWPQDQFPTSENAIYDAVAKLWSPWLNPAAVATLQKGGFYSLVIK--PGLRLLSLNTNLYYS--------------------------PNEVTVNMSDPAGQFQWLQETLELSRQSMEKVYVIAHVPIG-----------------------------YLPFAKNTTAMRENYNEQLVKIFRNYSEVVEG-------------QFYGHTHRDSIMVLLDQQG-------KPVNSIFVTPAVTPIKSQIEPFSNNPGVRAYLYQPDSYTLLDIWQFYLNLTEANLE-------QRSGWKLEYIMTEAFGIDDIQPGSLQELALRFEKPQSKAFDKYFSNFMVSYNISARCEGDCKTVQVCAVHYLDRESYSQCIDKRQKD--------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IQD3-1", "uniprot_id": "Q8IQD3_DROME", "id": "Q8IQD3-1", "name": "", "aln": "---------------------------------MLLAPISWLGFLLAYSGLPG------------------------------------AQARIGYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAASEPPGPFGHYN--CDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSH--SAQP-LSEQKQHEILRNITELLGRSFSS----------QFIFPVLGHED----------GSGSYRRLGELWRHWLPSEALVTFDQGGYYSIEQT-KSRLRIVALNTNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKSKEKQETVYIVGHMPPGVD-------------------------ERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQG-------------QFFGHLHSDTFRLIYDAKG-------NPISWLMIAPSIVPRKAGIGSS-NNPALRLYKFDTGSGQVLDYTQFWLDLPLANRA-------NEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTDLSWFTRYHRANAVRYHSGSACPGLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALMPTSWSWLLGVLAVFYGLHAERWSGGCNNCHIQRI------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04119-1", "uniprot_id": "PPN1_YEAST", "id": "Q04119-1", "name": "Endopolyphosphatase", "aln": "MVVVGKSEVRNVSMSRPKKKSLIAILSTCVLFFLVFIIGAKFQYVSVFSKFLDDRGDNESLQLLNDIEFTRLGLTPREPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVCHTGKP--------SKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQTREYYRIWKNFVPQQQQRTFDRSASFLTEVIP-GKLAVLSINTLYLFKAN----------------------PLVDNCNSKKEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHFIPTDGKKARKSLLKAMEQSTRVQQGEDSNEEDEETELNRILDHAMAAKEVFLMGAKPSNKEAYMNTVRDTYYRKVWNKLERVDEKNVENEKKKKEKKDKKKKKPITRKELIERYSIVNIGGSVIPTFNPSFRIWEYNITDIVNDSNFAVSEYKPWDEFFESLNKIMEDSLLEDEMDSSNIEVGINREKMGEKKNKKKKKNDKTMPIEMPDKYELGPAYVPQLFTPTRFVQFYADLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDSLTVGSYLDLAGRLYENKPAWEKYVEWSFASSGYKDD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . * *::*:* *. * . * . . **. **** *: .:. :* : .*::**** * : .: :: : *. : * **:.* . :* :: *: :.. : * ::::** . . *: .* .*:: .*:* :: : : .: :. ... : * * :: .* . .: . : ..: : :* : . . : : . .* . ** :*. :: : : . : : : ", "identical_positions": 44, "similar_positions": 95, "identity": "6.24%" }, { "cls_id": "homologset.agr.HGNC:1739", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z1X9-1", "uniprot_id": "CDC45_MOUSE", "id": "Q9Z1X9-1", "name": "Cell division control protein 45 homolog", "aln": "--MFVTDFRKEFYETVHN-------QRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAYLEHKEQFSYFILINCGANVDLLDILQPDED----------------SIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRD---EAEDE----DLSDSDGDG-SEPSE------KRTRLE---EEIVERNRKR-RQRREWEA-------RRKDILFDYE--QYEYYGTSSAMV------MFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVSLKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESPEKDGSG--------------------------------TDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGTPDVTLFSKPASLSLLSRHLLKSFVYSTKNRRCKLLPLVMAAPLSVEQGTVTVVGIPP--------ETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "B1WBZ4-1", "uniprot_id": "B1WBZ4_RAT", "id": "B1WBZ4-1", "name": "", "aln": "--MFVTDFRKEFYELVHN-------QRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFSYFILINCGANVDLLDILQPDED----------------SIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRD---EAEDEE---DLSENDDGG-AEPSE------KRLRLEGLEEEIVERNRKR-RQRREWEA-------RRKDILFDYE--QYEYYGTSSAMV------MFDLAWMMSKDLNDMLWWAIVGLTDQWLHDKITQMKYVTDVGVLQRHVSRHNHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMG---------------------------------MKDIRVQTFSIQFGFRHKFLASDVVFATMSLMERPEKDGSG--------------------------------TDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGTPDVALFSKPASLSLLSRHLLKSFVCSTKNRRCKLLPLVMAAPLSMEQGTVTVVGIPP--------ETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O75419-1", "uniprot_id": "CDC45_HUMAN", "id": "O75419-1", "name": "Cell division control protein 45 homolog", "aln": "--MFVSDFRKEFYEVVQS-------QRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFHYFILINCGANVDLLDILQPDED----------------TIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRD---EEEDE----EHSGNDSDG-SEPSE------KRTRLE---EEIVEQTMRR-RQRREWEA-------RRRDILFDYE--QYEYHGTSSAMV------MFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSG--------------------------------TDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPP--------ETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7ZU79-1", "uniprot_id": "Q7ZU79_DANRE", "id": "Q7ZU79-1", "name": "", "aln": "--MFVTDIRKEFYDVVVN-------QRVALLVSSDIDALCACKVLQALFHCDHVQYTLVPVTGWQDLGTAFLEHKEQYKYFVLINCGANVDLLETLQPEED----------------SVFFICDTHRPVDVVNVYNDSQIKLLIKQDDDLGVPSYDDIFRD---DEEDEEADGDDSGNESDGSAEPSG------KRRRFD---EDALERRIERQRARREWEA-------RRREILFDYE--QYEFHGTSAALV------MFELAWVMSKDTKDMLWWSIIGLTDQWVHDKIPHMKYVTDIATLQRHVSRHNHKNEDEENSLSIDCMRINFEYDLRLVLYQHWSLYESICNSCYTSCSFKLWSINGQKKLQEFLADMGLPLKQVRQKFNSMDMTIKENLREVIEESATKFGMKDIRVQTFGVHFGFKNRFLASDVVHAAAALLENVEKDETP--------------------------------TDNFIKALDCLSRSNLERLHLGIDLAKKKLKAIQQTVASCICTNLILSQGPFLYCHLLEGTPDVKLFSKPLSLTLLSKYLLKAFVCSTRNKRCKILPLIMAAPLDIEKGTVIVMGIPP--------ESETSDKKNFFGRAFEKAAESTSSRTLHDHFDTSVIELKMEDRGKFLDALITLLS-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "O96989-1", "uniprot_id": "O96989_DROME", "id": "O96989-1", "name": "", "aln": "--MFVQDLRNDFYRQLVG-------KRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEHQGDVKYVVLVNCGGCVDIVELLQPSDD----------------VTFFICDSHRPLDVCNIYSDRQVCILGDASLEENIPAFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSR--LERHEQRILKQRARRQWES-------ERDRIMFEYT--QFSYYGRSAALM------VFELAWKLSKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTNDQN---TMSASKITFENDLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLLEMGLPLVHARQTYGAMDLVLRKEFFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAADYVYALLAIMESVKKHKTP--------------------------------EDCFLEASDALSRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQVHSAGSFFYYVLQE---EHAFFSYPYALGLLARFLLRGHVATSRARQASDLPLIASCPLNASEGMCLLVGIVP--------VREDSPR-NFFGKAFEQAAQKSGVALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q08032-1", "uniprot_id": "CDC45_YEAST", "id": "Q08032-1", "name": "Cell division control protein 45", "aln": "MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYK-LLELDEESGDDELSGDENDNNGGDDE----ATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTS---LDIAYAQVYNRLYPLLQDEVKRLTPSS--RNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDG-PDLDLYRNPLTLLRLGNWLIECCAESEDKQ---LLPMVLAS-IDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :: : : : . : : :. ::**:** ::*. **: : : :**: * * : : . : .:*:. *. :*: *: . : ::: *:*** :: *::.. : : . : : . : . : ::* : . ..... . . .. : :. . * . . . .* :.:* .::. .:::: ::.* :.: . ** *:* *. . * :* .*.* . . .: : . :.:: * *.* :* .: :*: : * . :.**. .*:*:*:::: ** : *: * *:: *:: * * :::* :. . . * : *.*. : : * *:: *: * . : : . : : * : : :: * :* *.. *:. . : : **:: :. :. . . : *: * . * *. **:: : .:. : *: :::::: .* **: * ", "identical_positions": 79, "similar_positions": 196, "identity": "11.88%" }, { "cls_id": "homologset.agr.HGNC:17393", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XI50-1", "uniprot_id": "MARH7_RAT", "id": "Q5XI50-1", "name": "E3 ubiquitin-protein ligase MARCHF7", "aln": "MESKPSRIPRRISVQPSGSLSARMVSGN----------RGTSLNDSYHSRDSSFRLDSEYQ-----------------------SASASASASPYQSTWYSESEITQGARSRSQNQQR-------------DHDSKRPKLSCTNCTSTSAGRNIGSGLNTLS--DSSWRPGQVPRS-----SSMVLGSFGTDLMRERRDLERRRDSSISSLMDYSHRSGDFTAPAYVQERVPSSYSQGARPKENAANTLQLN-SSTNHQLPSEHQTVPSSRDSS--RSSFRSHFSPRQ---SESFRNSS-HPAFSYLSSRNETPTISSSERA--------GSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSEN--YISPRTLTS-QSRNNGASSS-EVNDGRASEASQGFRFLRRRWGLSSLSQNHSSEPDAENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRISPSDVPPRSHLFR---RESNEVVHLEAQGDSLGAAASRPQASGASG-NASASGSTPDLPQGGRNTGIAGILPGSLFRFAVPPALGSNLTDNVTITVDIIPSGWSSADGKSEKAKSAPSRDPEKLQKIKESLLLEDSDEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETSEDEF------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9WV66-1", "uniprot_id": "MARH7_MOUSE", "id": "Q9WV66-1", "name": "E3 ubiquitin-protein ligase MARCHF7", "aln": "MESKPSRIPRRISVQPSGSLSTRMVSGN----------RGTSLNDSYHSRDSSFRLDSEYQ-----------------------SASASACASPCQPAWYSESEIPQGARARAQTQQR-------------DHDSKRPKLSCTNCASTSAGRNGGSGLNTVS--DSSWRHSQVPRS-----SSMVLGSFGTDLMRERRDLDRRRESSISNLMDYNHRSGDFTTSSYVQERVPSSYSQGARPKENAVSTLQLNSSSTNHQLPSDHQTVPSSRDSS--RSSFRSHFSPRQ---SESFRNSS-HPAFSYFSSRNETPTISNSER---------GSSQRPYRESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSEN--YISPRTLTS-QSRNNGTSSSSDVSEGRAAEASQGFRFLRRRWGLSSLSQNHSSEPEAENFNQESEGRNSGPWLSSSLRNRCTPLFSRRRREGRDESSRMSTSDVPPRSHIFR---RDSNEVVHLEAQGDSLGAAANRPQASGASS-SAAAGGSTPELPQGGRNPGLTGILPGSLFRFAVPPALGSNLADNVMITVDIIPSGWNSTDGKNDKAKSAPSRDPEKLQKIKESLLLEDSDDEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETSEDEF------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H992-1", "uniprot_id": "MARH7_HUMAN", "id": "Q9H992-1", "name": "E3 ubiquitin-protein ligase MARCHF7", "aln": "MESKPSRIPRRISVQPSSSLSARMMSGS----------RGSSLNDTYHSRDSSFRLDSEYQ-----------------------STSASASASPFQSAWYSESEITQGARSRSQNQQR-------------DHDSKRPKLSCTNCT-TSAGRNVGNGLNTLS--DSSWRHSQVPRS-----SSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVP-SYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDS---RNSLRSNFSSRE---SESSRSNT-QPGFSYSSSRDEAPIISNSERV--------VSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENS-YVSPRILTASQSRSNVPSAS-EVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFR---RESNEVVHLEAQNDPLGAAANRPQASAASS-SATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDS-EEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA-----------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NG75-1", "uniprot_id": "A0A8M1NG75_DANRE", "id": "A0A8M1NG75-1", "name": "RING-type E3 ubiquitin transferase", "aln": "MDSKSRRFPFAVSSSSSLSSPSSLSSSSSALSASRLYGRGSVLGRDRFSRDASVKLDSDYQGSRLLSSPRVYSSTESRHSNWKLSTPVTSSSSSSSSCDRSWTESSSGDRARLTDSERRLGTYCGLLGTSQDSESKRAKLSYTNREVYSRSPSTSKPATSYSTLGSSWKSSISPLSRSSSSSSSSSVSTQSEGLWARRDLEKRVDSGLSSLGESSYRPSSLTSSLYRSERVASTYAQGARPKDSQYSSHREN-SSSSRRIPSEYIPSPLERNSQRLTSDYQSNLFPRDTPRSSSTRTSTSVSDTSHHSSWSSTPYTALSACTSSPPSISPAPTPLPAQNTGESDGRGTTRRLLSR--------LFSRRSSQESNSTASTASDSRSYDSSPDEAPPTEAPPPISRENLEAELRNSDPAQAFSFLRRR-GPSLAPVQESTDVEPE---QESLRPPAG--LSWLNWNRCTPLFSRRRREGRDESARMDPHRSPQFSLGDRDGRKTPDQGTHCEDDDDEDDDDEDESSEGAAAGPSSGASALSASLLQDG--AHLAGRSHG-MGRGMNSPLFR--LPENVLIGVGVE--GRSQAD-EQPKDKPAPSRDPERLRKIQESLLLEES-DEEEGDLCRICQMGEQWSSNPLIEPCKCTGSLQYVHQDCIKKWLRSKISSGSNLEAITTCELCKEKLHLNIENFDINELYRSHE--RSEYEFISCGLYLVVLLHLCEQRFSDVLGAVNDAG----FFNLARTLHEHMDNLESSYAESDEDEVEDSRPSIDFCDLEDDDEEEEEEEEV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:**. *:* :* ..* * .: : *.. **: *. .***:*.:***:** *:..::.:*. .. * :* ..* *:* .:* * :***.*** ** * . . .. .: * .***: . * * ** * :: : ****::* :*.:*.* : .:*...:*:. * .:**. :*:******:. .: : * **:.:::**:: . .*:* .. :*:: .*: *.* *..: . *: ** ..:* : * .: * :::.:.:** ******** :*******:* .* * *:. * *. :. . * . : * ::.:*.* ***** * * . :.*:: :.* *** :* ** ******************:*: . . * * : .:: .* * :.* . .... ..*:. .: :.. :.. *.* . ::* * : * .* : *.:** * *.: * ..:* :. * *.*******:*:**:******:* :************. *** ****************:*:****::**.***.***:**********.**:*:***:**:*:* ::******.************* ***::* . :.. *:******: **::**:* : ", "identical_positions": 284, "similar_positions": 212, "identity": "35.59%" }, { "cls_id": "homologset.agr.HGNC:17397", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R1T1-1", "uniprot_id": "BAF_RAT", "id": "Q9R1T1-1", "name": "Barrier-to-autointegration factor", "aln": "-MTTSQKHRDFVAEPMGEKPVGSLAGIGDALGKRLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O54962-1", "uniprot_id": "BAF_MOUSE", "id": "O54962-1", "name": "Barrier-to-autointegration factor", "aln": "-MTTSQKHRDFVAEPMGEKPVGSLAGIGDVLSKRLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75531-1", "uniprot_id": "BAF_HUMAN", "id": "O75531-1", "name": "Barrier-to-autointegration factor", "aln": "-MTTSQKHRDFVAEPMGEKPVGSLAGIGEVLGKKLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6P026-1", "uniprot_id": "BAF_DANRE", "id": "Q6P026-1", "name": "Barrier-to-autointegration factor", "aln": "MSSTSQKHKDFVAEPMGEKSVMALAGIGEVLGKRLEEKGFDKAYVVLGQFLVLRKDEELFREWLKDTCGANTKQQGDCYSCLREWCDSFL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VLU0-1", "uniprot_id": "BAF_DROME", "id": "Q9VLU0-1", "name": "Barrier-to-autointegration factor", "aln": "MSGTSQKHRNFVAEPMGNKSVTELAGIGETLGGRLKDAGFDMAYTVLGQYLVLKKDEELFKDWMKEVCHASSKQASDCYNCLNDWCEEFL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *****::*******:*.* *****:.*. :*:: *** **.****:***:***:**::*:*:.* *.:** **:.**.:**: **", "identical_positions": 52, "similar_positions": 26, "identity": "57.78%" }, { "cls_id": "homologset.agr.HGNC:17399", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LN08-1", "uniprot_id": "A0ABK0LN08_RAT", "id": "A0ABK0LN08-1", "name": "Rho GTPase-activating protein 32", "aln": "MTGLSHLAVSVDLHDQLWSSPQDEGNQISFICSHHVHLQILYDATALE-NRKMKSSIHSEEDDFVPELHRNVHPRERPDWEETLSAMARGA-DVPEIPGDLTLKSCGSTASMKVKHVKKSTPPGLMGCDNIHRLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEIMKNGCESKEL-----------------VYLVQIACQ-GKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDILKDSPESVTQMLAAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHE---ESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHG------FQVGLFPGHCVELINQKVPQSVTNSVPKP------------------------------------------VSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKISAVMQEG--AASLTRPKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGR-AEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEVLGNR--CNSYDNLPHDNESEEEVGLLHIPALVSP-HSAEDVDLSPPDIGVASLDFDPMSFQCSPP--KAESECLESGASFLDSLGFTRDKLGASKKDVEAGGSQSQTPGSTASSEPVSPVQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMNISEPISVTLPPRVSEVIGTVSNTVSQNASPPSWDKSVEERDVINRSPT--QLGKMKPGEREAQERCEPEAQPQEQGAAEEVELPGTEERPVSSSQSKAVPSGQSQTGAVTHDPPQDPVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQTLKRPGPSQAGCTSYGDMAVATSEEKLPSSYSSVTLDKTYFQTDRPAEQFHLQINGLGNCDQPLPETAAMGGPTHPNTTDSGEQLHQVDLIGNSLHRNHLSGDPEKARSTSAPLADSEKSDGHGSFPEDHAGKTSVSTVSFVGQGQSPLHFSSGDQPLSYLGTSMDKPHHSSELTEKSPMPSTLPRDKAH-PLSGSPEENTSTATMAYMMTTPPRAETSTREASRAMAEQPTAADFVAATLQRAHRTNRPLPPPPSQRPTEQPPGVGQVQEAPSIGVNNSHKQVQGAAPAPERPPEPRAMADPAPIFVSD-GSAAAQCPMAISAAQPGLPEKVRESSRAPPLHLRAETFPGHSCGFAAPVPPTRTVESKMAAAMHSSAAEANNSSNYHSFVPSS-ASADDVLPLPPPIAQPKHASQKIAYSSFARPDVTTEPFGPENCLHFNMTPN------CQFRPQSVPPHHN---KLEPHQVYGTRSEPPASMGPRYNTYVAPGRSMSGHHSKPCSRVEYVSSLGSSVRNP-CCPED-ILPYPTIRRVQSLHAPPPSMIRSVPISRTEVPPDDEPAYCPRPVYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRPLHRLSNRDFAFYNPRLQGKNAYNYAALPPRPRASATGYFSSNDHNVVNMPPTADVK-HTYTSWDLEDMEKYRMQSIRRESRARQKVKGPIMSQYDNMAPAVQDDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKAVSPEGDERFYRKHPESEFDRAHHHGGYGSQQVEKPSLPQKQSSLRNRKLHDMGCSLPEHRAHQEASHRQLCESKNGPPYPQGAGQLDYGSKGMPDASEPNSYHNSG-KYVTSGQESLRLNHKEVRLSKDVDRPRARQPPAPEKHSR-DCYKEEEHFTQSVVPPPKPERSHSLKLHHTQNLERDPSMLYPYQTHSKRQSSVTVVSQYDNLEDYHSLPQHQRGGFGGGGMGAYVPSGFVHPQS-RTYATALGQGAFLPTELSLPHPDTQIHAE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q811P8-1", "uniprot_id": "RHG32_MOUSE", "id": "Q811P8-1", "name": "Rho GTPase-activating protein 32", "aln": "------------METESETSSLGDDSVFWLDCEGVTQLTDGDEEEREESFRKMKSSIHSEEDDFVPELHRNVHPRERPDWEETLSAMARGA-DVPEIPGDLTLKSCGSTASTKVKHVKK--------------LPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKEL-----------------VYLVQIACQ-GKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLTELPRSDVLKDSPESVTQMLTAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHE---ESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHG------FQVGLFPGHCVELINQKVPQSVTNSVPKP------------------------------------------VSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKISAVMQEG--AASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVSSPIVTENKYIEVGEGPAALQGKFHTVIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGR-AEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGDVLGNR--CNSYDNLPHDNESEEEVGLLHIPALVSP-HSAEDVDLSPPDIGVASLDFDPMSFQCSPP--KAESECLESGASFLDSLGYTRDKLSPSKKDAEAGGSQSQTPGSTASSEPVSPVQEKLSPFFTLDLSPTDDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMNISEPISVTLPPRVSEVIGTVSNTVAQNASPTSWDKSVEERDVINRSPTQLQLGKMKAGEREAQETCEPEAQPLEQGAAEEVELPGTEERPVLSSQSKAVPSGQSQTGAVTHDPPQDPVPVSSVSLIPPPPPPKNVARMLALALAESAQQASSQTLKRPGASQAGCTSYGDTAVVPSEEKLPSSYSSLTLDKTCFQTDRPAEQFHPQINGLGNCNQPLPEAAAMGGPTQSNTTDSGEQLHQVDLIGNSLHRNHISGDPEKARSTSAPLTDSEKSDDHGSFPEDHAGKSSVSTVSFLEQDQSPLHFSCGDQPLSYLGTSVDKPHHSSELTDKSPMPSTLPRDKAHHPLSGSPEENSSTATMAYMMATPARAEPSNSEASRVLAEQPSAADFVAATLQRTHRTNRPLPPPPSQRPAEQPPVVGQVQEAPSIGLNNSHK-VQGTAPAPERPPESRAMGDPAPIFLSD-GTAAAQCPMGASAPQPGLPEKVRESSRAPPLHLRAESFPGHSCGFAAPVPPTRTMESKMAAALHSSAADATSSSNYHSFVPSS-ASVDDVMPVPLPVSQPKHASQKIAYSSFARPDVTAEPFGPENCLHFNMTPN------CQFRPQSVPPHHN---KLEPHQVYGARSEPPASMGPRYNTYVAPGRNMSGHHSKPCSRVEYVSSLGSSVRNP-CCPED-ILPYPTIRRVQSLHAPPPSMIRSVPISRTEVPPDDEPAYCPRPVYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPEGALCDVDAYGTVQLRPLHRLSSRDFAFYNPRLQGKNVYNYAGLPPRPRANATGYFSGNDHNVVTMPPTADGK-HTYTSWDLEDMEKYRMQSIRRESRARQKVKGPIMSQYDNMTPAVQEDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKAVSPEGDERFYRKHPESEFDRAHHHGGYGSTQAEKPSLPQKQSSLRNRKLHDMGCSLPEHRAHQEASHRQLCESKNGPPYPQGAGQLDYGSKGMPDTSEPSNYHNSG-KYMTSGQGSLTLNHKEVRLPKDLDRPRARQPPGPEKHSR-DCYKEEEHFSQSMVPPPKPERSHSLKLHHTQNLERDPSVLYQYQTHSKRQSSMTVVSQYDNLEDYHSLPQHQRGGFGGAGMGAYVPSGFVHPQS-RTYATALGQGAFLPTELSLPHPDTQIHAE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A7KAX9-1", "uniprot_id": "RHG32_HUMAN", "id": "A7KAX9-1", "name": "Rho GTPase-activating protein 32", "aln": "------------METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGA-DVPEIPGDLTLKTCGSTASMKVKHVKK--------------LPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKEL-----------------VYLVQIACQ-GKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHE---ESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHG------FQVGLFPGHCVELINQKVPQSVTNSVPKP------------------------------------------VSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEG--AASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGR-AEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNR--CNSYDNLPHDNESEEEGGLLHIPALMSP-HSAEDVDLSPPDIGVASLDFDPMSFQCSPP--KAESECLESGASFLDSPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPT--QIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLD-SEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIY-PPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHK-VQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMAT-AVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPN------CQYRPQSVPPHHN---KLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSSLSSSVRNT-CYPED-IPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVK-HTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSR-DCYKEEEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVFGGGGMGTYVPPGFPHPQS-RTYATALGQGAFLPAELSLQHPETQIHAE", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3ALJ2-1", "uniprot_id": "A0A8M3ALJ2_DANRE", "id": "A0A8M3ALJ2-1", "name": "Rho GTPase-activating protein 32", "aln": "------------MEAGSGAAAVVGSAALGLLGATGSHDIS---DSLFSPLRGLRPGRHPEEDDIVPELARSIHPRERPDWEETISAMARSA-EIPELSSEPLMRSCSSTASMKVKNVKK--------------LSFTKGHFPKLAECAHFHYENVDFGTIQLTLADEQTEVTRNGLESKEP-----------------VYLVQIYCQ-GRSWIVRRSYEDFRVLDKHLHLCIYDRRFSQLPELPRFDSLRERAEAVSQMLMAYLSRLSAIADNKINCGPALTWMEVDNKGNHLLVHE---ESSINVPAIAAAHVIKRYIAQAADELSFEVGDIVSVIDMPPKEDTTWWRGKHG------FQVGFFPSECVELINDKVPQSVTNSVPKPASPCSGLRPASWSLFPPYLEMESIKQDSALAPDPLNPYRLSSVSKKHGKLITFLRTFMKSRPTKQKLKQRGILRERVFGCDLGEHLLNSGHDVPQVLKSCTEFIEKHGVVDGMYRLSGIASNIQKLRHEFDSEQIPDLTKDVYIQDIHCVGSLCKLYFRELPNPLLTYQLYEKFSEAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFLMRHLSHLATFSYVTNMHTKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSPKLSSLIREGTGHNSLSRPKSLLVPSPSTKLLTLEEAQARTQAQINSPITADSKYIEVGEGPAALQGKFHTVIEFPTERKRQPMKSKKSPVGSWRSFFNLGKSSSMSKRKLQRNPSEPNELKAMALAGGRGDTGTLRSAKSEESLTSLHNVEGESKVYRPRRPRSSSDALSASFNGDLLDTRQHCNSYDNLGHG-DSDGDDGPICVPALISPPRSADDVDLSPPDIGMASLDFDPMSFQCSLP--LAETSIFS--------------------IDADT-SSLKRSP--ASGSESVSPVRAKVTSRF---LSP--DHSTALKDKHKLLLTSFSEKTPVQSVESTEMSAVVSPPSISESAASVIMKGPESTVLQPSSPPSPLDSPTKLSSLSRTTD------LPLSEAIQQELLSKAAT-----------FESKDISSIECSQPPQVTCSQEQPGAVALDSPKGNVPVSSVSLVPPPPPPKNAARMLALALAESAQQATILSQKQSSGPPT-----------------------------------PVSPLRPQE-LLETLDWPLPSSLPSQPSEEETAVESSN---------------------KSVPLSSPPSTPPEKMTRSVSLHLTTADSGKPSSISCNSQDVISPETPSQSAMPSCLTSHVSQTQKSPEKQQ--------------------PAVGQTPVSTAKTTTTTTTSTISSKDA---VIQQPTS---------EIHMPETVLPPKPNKVPD-QPVAILQPQPQMQTQPHTAFR------SQPQVQPLPQSQAQPQSQPRSQ--PNARVAPTLAAPHDP--VEKPWEAIKPVHPKGDSASQQHHTQGVTPPTPPIRSIESKLAAAALCN-TEAANPANFHAMLETSMRGSVEETPPQSHPPHRRSSTHQSGYLYHTKGEAALLDPTTEAYYHQRVTPSGQATVGYHYRPESVPPHISYVSKSEPHISYRGHGDG------RYNT-IGPRSYHQSIKSRGSLRSEYISPSSLHHSHS-YSQADGPTVYPTIRRVHSLHVPP-TAIRSMPVTRTEVPPDDELFYYQRPIYHCKSHQPS-SQVDYHVTQLQPYFENGRVQYRYSPYSGS----HVLESPFYDVDHYGTIRLRHVHSFSGRDSAPLLRSGAKSGGYHYLSRHVIP-LKEHGFISR------DMPPYSGSKGSIYFAWDPEEAERLRIHSIRRESRARQKVKGSVMSQYDNVGPYMPVDVD---MLHLRSKSDPGKT-VLVSSESKEARYNVVPGS-QHAPRHLISDPDVLMYMETEKHCQGNGMGEKTTK--QGSSRTYSSIHSHQSQLPPLSRQHLPEG-----GHHDPKFEPGEKQLSG-----KHWQEHSDSRSAQARYERSDLDRHICRVKATSSASEDEQAAPVKPAPPPKPERSHSVRERHHYNQSSLPAYLPD-----------NSDRDHSGTYSHQSQGQRQSTVTLQSHYDNLDDYHPVPQSQTTLANRGCSSSYHSPGFSTPHSNRAYSTALGQGAFIQAELSVQRPETEINAE", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "F1RDK4-1", "uniprot_id": "F1RDK4_DANRE", "id": "F1RDK4-1", "name": "Rho GTPase-activating protein 32", "aln": "------------MEASSRTAAATNARASTPPTDASTHDPS--------------EGPHPEED--EGEEDRSLQPAETAGWEDAIAVMARGAPTVPELPAESSLRSCVSTASMKVKNVKK--------------LSLTKRHFPKLAECAHFHYENVDFGSVQLSLTDEQNDLTNNGLDSKES-----------------VYLIQICCQ-GRKWTVRRSYEEFRVLDKHLHLCIYDRRFSQLPELPRIDSLKDKTGTLSQMLTAYISRLSAIADNKINCGPALTWMEIDNKGNHLLVND---ESSINVPAVAAAHVIKRYIAQAADELSFEVGDIVSVIDMPPKEDTGWWRGKHG------FQVGFFPSECVELISEKIPSNVTSSLAKP------------------------------------------VSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGHDVPQVIRSCTEFIERHGVVDGIYRLSGISSNIQKLRHEFDSEHVPDLTKDTYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDD--ERLVKVHDVIQQLPPPHYRTLEFLMRHLSRMGTYSNVTNMHCKNLAIVWAPNLLRSKQIESACFSGTSAFMEVRVQSVVVEFILNHVDVLFSPKLSTLIRHSTGHTTLARPKSLLVSSPSTKLLSLEEAQARTQAQLNSPVSPDSKYIDVGEGPAALQGKFHTVIDFPSERKKGSTKGKKSPVGNWLSFFNMGKSSASAKPKLHRHPSEPNDMKTTPLPGGRGDTGTLRSAKSEESLSSSHNFEGGSNIYRPRRPLSTSDALSLSFNEELLDSRLTGDSRSSLKDHRKDTSSSS--CVPALISPPHPSADAEF----IGISSLDIDPLAFQSARL--VEQ--------------------------ENKKKGSRKKAGGKNHELEPSNKVTS----------------PSQPPDLIPLRAEDSKHRPSELPLSSTNLDVGFS--------KTGQMGTSRSSVPKSSTVS----CPSDIVSLMKKPS----VSMKAGEGHQRSAS----------------FCKTESKSADVKQHR-----RADSGAVTFECTPG--LVRSVSLITPQPAVKSAARMLALALAESAQQATRLSKRGSSEPPT-----------------------------------PISPIHHKN-PLFTLQFPPPVQTSSDREERYASN--------------------------RAFPDPSSTMSTESHTDAGSLRSTCACHGSESGLSFSDG---------CDAPAGGQCTHVPSQGFSP--------------------------RTDPEIQLVQETQTTLRDNIR-------------------------------------------HVGVGTDGGGSSLDAEMEVR-----------GSLQTTLSERYSSLDSP-----------------------------------------------SAIDALHNKQAANAANFRAILAETAMPASVQEVLPQASSTPPSVLYQYKPREQRSAYSQHSQQWSSSDGQSTSYYQVDDGRPHPRVLSR------------------------------------------SYCNTLAPRSLHQSIKYKG-QREDYSSVGVYRHGGPRYPPLDGASVYPTIRRVRSMHTPP----------------EDKFFFLQRQGSQSKPYQNP---PPSDIQHVRPYFEDGKVRYRYSPYSEARYNQYREN--------SGYTLSYTLNKLPSRS-----SKVMATSENYHKPLRNLPLNNESDFMTRD----AGFLPRKKNP-SFYEAFNSGLSDRHFSQSIRQENAAKERPLGPVVAQPH----LVRCDRQCQETMHTRSRSNSGKE-MLISTEGADGKYRVTMVS-HYSPEHPLSEPDMPVPSKSDRHDSGQGAKSALIMKQSRSMHNYPQHRLESTALPHNLTLHKEYS-------------------------CPDFKHTGSSDSFG----VTHRNQDRLIYKTLSNPKEDYQYIQAMSREPQRSKRSQSVKNRNPPGQAKMT-----------------LERDHRLPFSSHSR-TRTRSMYVPSRSDYSESYVSAHP-KVPKSSRASSGVFPNYGCMPLYSNRLYSTAVGHAGFHQTEL---RPEMQIYAD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VIS1-1", "uniprot_id": "CDGAP_DROME", "id": "Q9VIS1-1", "name": "GTPase-activating protein CdGAPr", "aln": "----MSDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMN--TSQISNASTESSCSPPIQGAVPPPKPSR------HMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVG--------------------------------HLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESG---GVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHS--RVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPR----SWQKRKPDKTPSWKSIFS--------RSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVS-----------------------------HDSYFDLLQSPQRGHMTTCPSRELSELGLNFD-------REEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYK---------LEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFS-----------------------------------YQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVE-------------------DGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLG--------------------------VDASSSYLGSSHESLGQNINN-----------------------------------------HHDAEQRDMNALKRELSLDLN------------PLQPRLPQPANR---------------------------------------------------AATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSP-------------------------------------------------EKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYG-----------------DTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGGGSECTLHTGLSQGNGQEHLGQQRVRRISDE------------KNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTSKTPANKFERSQPMPRDRLQRNSLAESNAGTNNREKISPQFSIRDVTAMFESRSQNQ--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : . .. : .: * : . :* .::. :* .. . * * * .. :***: ********.*::*.:.: * :::.: .. *:. ::::: * . : ::**:*::::**: ** *:***::* * :: . : : *:.*:* **.:.:.**. ***:::****.:* : : : :**.**:.**: ::** *:*.**:.:****::******. : *****:. ::**:** ** *.:*:* ... . . * :******:*:*:*: ***::::*** ** :****.***.******* ::* *::**: ***.:*::**:*****::****:**: **.*::*** : ****.*.** *:********* *****::* :*:.. :*: *** :::.: :*********::* .** :. . *.* ************** :**. *.:*: * :*:**.*:::.: . :*. . :.. : : . . . : *: *: * : ...: .: .:. * * * . .: .. * . :. *:. * . . *. : :: *. : * . * : :. *.::: : .. * . . . .:. :: .. * . . . :: .: : : : : * .:*.: . . :: . . . : ... . : : : . . . * . : : : .:* . . . . .: .. . . : : *.* .: . : . . : . * * . . . . : . . :. . : : . . . . . . : .. . : * . :: . . : : . . . . : . : .::::: . . ::: . : : .: :* .:: . : . . :. : ::: :* .:: .: : : : :: . . : : :* : : . : .: .. . . : .. . * . . .. * : ::: . : : : : . : . . : :. .. : ", "identical_positions": 241, "similar_positions": 419, "identity": "10.89%" }, { "cls_id": "homologset.agr.HGNC:174", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P38445-1", "uniprot_id": "AVR2B_RAT", "id": "P38445-1", "name": "Activin receptor type-2B", "aln": "--------MTAPWAALALLWGSLCAGSGRGEAETRECIYYNAN-WELERTNQSGLERCEGEQDKRLHCYASWRN--SSGTIELVKKGCWLDDFNCYDRQECVATEENPQ--VYFCCCEGNFCN--ERFTHLPEPGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRK-PPYGHVDIHE------------------------DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGCSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNSSTSDCLVSLVTSVTNVDLLPKESSI-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P27040-1", "uniprot_id": "AVR2B_MOUSE", "id": "P27040-1", "name": "Activin receptor type-2B", "aln": "--------MTAPWAALALLWGSLCAGSGRGEAETRECIYYNAN-WELERTNQSGLERCEGEQDKRLHCYASWRN--SSGTIELVKKGCWLDDFNCYDRQECVATEENPQ--VYFCCCEGNFCN--ERFTHLPEPGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRK-PPYGHVDIHEVRQCQRWAGRRDGCADSFKPLPFQDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRG-SNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLLPKESSI-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q13705-1", "uniprot_id": "AVR2B_HUMAN", "id": "Q13705-1", "name": "Activin receptor type-2B", "aln": "--------MTAPWVALALLWGSLCAGSGRGEAETRECIYYNAN-WELERTNQSGLERCEGEQDKRLHCYASWRN--SSGTIELVKKGCWLDDFNCYDRQECVATEENPQ--VYFCCCEGNFCN--ERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRK-PPYGHVDIHE------------------------DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRG-SNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24468-1", "uniprot_id": "AVR2_DROME", "id": "Q24468-1", "name": "Receptor protein serine/threonine kinase put", "aln": "MSKYDLLYLTAQLTLVCCLIG-IHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECN-QTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSV-FSVLMVIVGMGLLLYRRRKQAHFNEIPTHE-------------------------AEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHM---DKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAG-PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPS------TQLLIKNHTNIDDAKESTNCL", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :** . :. * * : .. *. ** ::: : : : :: :*:*: * ** **. * ::* :.: ***: * .:* : ***:: * * ::****:*. ** ::: : . . .:*. * . ...*: : : : :. * :** :.: :**:** . :..: ** . . .***:. :*:**** ** **** **:*:* *: ****** :*:*:** :*::*:. * *:* *:*:*:..**: : * ***::::.:*** ****.: *:* ***::**:*:.**::***::* .: :* ********************** :******: *:**** ************************:********:** ******:****. *. **.*: **** *:* :***:*:** ** **:** : : * **** :* *:*************:.** **.: :.: . *:.. **:* :.:. ", "identical_positions": 237, "similar_positions": 147, "identity": "42.78%" }, { "cls_id": "homologset.agr.HGNC:17402", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZPT1-1", "uniprot_id": "D3ZPT1_RAT", "id": "D3ZPT1-1", "name": "", "aln": "MKFPCLSFRQPYAGLILNGIKTLETRWRPLLSSYQKCTVAIHIAHRDWEDDAWQKVLVERLGMTPTQIQTLLQAGEKYGRGVIAGLVDIGETLQCPENLAAADVVELETQAVLTNLHLKYLTPVSNPRWLLEPIPRKGGKDIFQVDIPEHLIPLEKEWSSECSGKQLGNGSAHRIS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9D1F3-1", "uniprot_id": "EOLA1_MOUSE", "id": "Q9D1F3-1", "name": "Protein EOLA1", "aln": "MKFPCLSFRQPYAGLILNGVKTLETRWRPLLSSVQKYTIAIHIAHKDWEDDEWQEVLMERLGMTWTQIQTLLQAGEKYGRGVIAGLIDIGETFQCPETLTAEEAVELETQAVLTNLQLKYLTQVSNPRWLLEPIPRKGGKDIFQVDIPEHLIPLEKE-------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96DE9-1", "uniprot_id": "EOLA2_HUMAN", "id": "Q96DE9-1", "name": "Protein EOLA2", "aln": "MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDACRELLVERLGMTPAQIQALLRKGEKFGRGVIAGLVDIGETLQCPEDLTPDEVVELENQAALTNLKQKYLTVISNPRWLLEPIPRKGGKDVFQVDIPEHLIPLGHEV------------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** **********::***:**:********** :: *:*:****:***.* :::*:****** :***:**: ***:********:*****:**** *:. :.****.**.****: **** :*****************:************ :* ", "identical_positions": 115, "similar_positions": 30, "identity": "65.34%" }, { "cls_id": "homologset.agr.HGNC:17407", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4ACQ4-1", "uniprot_id": "D4ACQ4_RAT", "id": "D4ACQ4-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------MTATAAVETPKMEKSASKEEK-------HQPKQKGSTDRDNADPEEWVNSESDPEP--MSFKSGHNSN--QSADIQLKKKE---MPSKPHRPLCRSPCLDRPSFSQSSILQDGKLD-------------------------LEKEYQAKMDFALKLGYAEEQIQSVLNKLGPESLINDVLAELVRLGNKGDSEAQ--VNLSLLLPRGASSREIASPELSLEDEIDNS-DNLRPVVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHKKQPCPYG-----KKCTYGHKCKYYHPERANQPQRSVADELRISAKLSTVKIMSEDTLAKCGTGMSTAKGEITSEIKRVASKRQSDPSIRSVAVEPEEWLSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLEHMVSMQYPPILVTNSHGTPINYTEQYPKFETMG-DHDYYSVLSDFSKLSINNMHN--HEYYMAEANQGVYVRNPGLCTDSHMSHTRNDNYSSYN-NLYLAVADAHPEGTLK--LHRAASHNHLQPFSHG-YHEALARVQSYGSEDSKQAPHKQSVPHLALHTQNPATGAHSSCPGDYT-MPPNIHP-VGPSQPGRALVMTRMDSISDSRLYDSNPMRQRRPPLCREQHASWDPLPCTADSYGYHSYPLGNSLMQPCYEPVMVRSMPEKMEQLWRNPWV----------GMCNDSRE-HMIPEHQYQTYKNLCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLRAAR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "G3X9I7-1", "uniprot_id": "G3X9I7_MOUSE", "id": "G3X9I7-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------MTATAAVETPKMEKSASKEEK-------QQPKQEDSTDRGNADPEEWANSESDPEQ--MSCKSGHTSY--QATDIQLKKKE---MPSKPHRPLCRSPCLDRPSFSQSSILQDGKLD-------------------------LEKEYQAKMDFALKLGYAEEQIQSVLNKLGPESLINDVLAELVRLGNKGDSEAQ--VNLSLLLPRGASSREIASPELSLEDEIDNS-DNLRPIVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHKKQPCPYG-----KKCTYGHKCKYYHPERANQPQRSVADELRISAKLSTVKIMSEDTLAKCGAGMSTAKGEITSEIKRVASKRQSDPSIRSVAVEPEEWLSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLEHMVSMQYPPILVTNSHGTPINYTEQYPKFETMG-DHDYYSVLSDFSKLSINNMHN--HEYYMAEANQGVYVRNPGLCTDSHMSHTRNDNYSSYN-NLYLAVADAHPEGTLK--LHRSASHNHLQPFSHG-YHEALARVQSYGSEDSKQAPHKQSVPHLAVHTQNPATGAHSSCPGDYT-MPPSIHP-VGPSQPGRALVMTRMDSISDSRLYDSNPMRQRRPPLCREQHASWDPLPCTADSYGYHSYPLGNSLMQPCYEPVMVRSMPEKMEQLWRNPWV----------GMCNDSRE-HMIPEHQYQTYKNLCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLRAAR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5HYM0-1", "uniprot_id": "ZC12B_HUMAN", "id": "Q5HYM0-1", "name": "Probable ribonuclease ZC3H12B", "aln": "------------------------------------------------------------------------------------------------------------------------MTATAEVETPKMEKSASKEEK-------QQPKQ-DSTEQGNADSEEWMSSESDPEQ--ISLKSSDNSKSCQPRDGQLKKKE---MHSKPHRQLCRSPCLDRPSFSQSSILQDGKLD-------------------------LEKEYQAKMEFALKLGYAEEQIQSVLNKLGPESLINDVLAELVRLGNKGDSEGQ--INLSLLVPRGPSSREIASPELSLEDEIDNS-DNLRPVVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPIVPEHKKQPCPYG-----KKCTYGHKCKYYHPERANQPQRSVADELRISAKLSTVKTMSEGTLAKCGTGMSSAKGEITSEVKRVAPKRQSDPSIRSVAMEPEEWLSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLEHMASMQYPPILVTNSHGTPISYAEQYPKFESMG-DHGYYSMLGDFSKLNINSMHN--REYYMAEVDRGVYARNPNLCSDSRVSHTRNDNYSSYN-NVYLAVADTHPEGNLK--LHRSASQNRLQPFPHG-YHEALTRVQSYGPEDSKQGPHKQSVPHLALHAQHPSTGTRSSCPADYP-MPPNIHP-GATPQPGRALVMTRMDSISDSRLYESNPVRQRRPPLCREQHASWDPLPCTTDSYGYHSYPLSNSLMQPCYEPVMVRSVPEKMEQLWRNPWV----------GMCNDSRE-HMIPEHQYQTYKNLCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLRAAR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q424-1", "uniprot_id": "A0A8M9Q424_DANRE", "id": "A0A8M9Q424-1", "name": "", "aln": "MVLELAAPAGAGPALQRCIPHIQRVFRVRVSCSAAESSCDSPNAGSSIIVNIEDGKEEDCTKAKEYIVSLISPVHKHRERLTLWLQRRLHALRAAIEYESCAVVQVRDHALELQGGHAQVTAACAMLQRLKMEHRGCRDPQPSPAAAGHESPEEEEEEEDEEAGEEGSSSESEGEVRPRSGSSGGVSS-AGSGDCPVGRRRDLLIAAKPHRQLCRSSCLDRPSFSQSSTLQELRADDTCTDPSQKALAPPSSASPMSLRQTSDRDYQTKMDFALKLGYSGEQVESVLSKLGANALINDVLAELVRLGNKGDPESQTAAGSASFAPRTVGAKEAVSPEASLEEDSSDTYDNLRPIVIDGSNVAMSHGNKEVFSCLGIQLAVDWFLEKGHKDITVFVPAWRKEQSRPDAPIKDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLACDSDGIIVSNDNYRDLQNEKPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHKKQPCPYGQYSKSKKCTYGHKCKYYHPERANQPQRAVADELRAFAKLSAVKTMSEGALAKCGTSGAANKGESGSEAKRVAPKRQSDPSIRSVACEQEERLCPMRKAEASSVPSLVSALSVPTMPLTKSHAAGALNTRSASSPVPGSLHFTHS--SLEHAGSVQYPPILVTNSQGASVAYGEPFPKYDSVVSDHGYYSMLSDFSTISLQDSFCSLEQPEPVGVGGGYSGRAPSMCPEPGRSHS-SDSFSSYSGEMYLNSLEGSLDDSMKSAPTQPSAQTRLQAFAHGFHHEALTRVQSYGTDEPKPGPRKQTSAHLAPHTQHAVVGARSSCPGDYPPLPQNVLPSVSPSQPGRSLGMTRMDSISDSRLYESNPLRQRRPPLCREQHASWDPLPCGNEPYSYGGYGLTGALMP-CCERVMVRSMPEKMEQIWRSPWDSVPPPPPATRGPAGDHQERHPIPEHQYQTYRNLCNIFPAYVVHSVMEKNPHMTDPQQLAAVIVTELRSCH", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :* * :: ***: ..:: : ::. : . :..: ** .***: * * .*. * . * : ::. : :**** ****.*********** **: : * :::**:**:*******: **::***.***.::*****************.*.* . : : ** .::* .*** ***:: .:: *****:*************** *** **********:************************.**:************************************ **************** *********************************************:************ **********************:****** ****:** ***.:*****:. :: *** ** ****.************ * ** *. **.*********:******:* .****.*************** **.*. **** *:**********:*:.: * * :**:::: **.***:*.***.:.::. . .: . .. * * *.:*.:. **: .*.:***. ::** : :..:* :.:::.:**.*.** :****:******.::.* .*:**: .*** *:*:. .*::****.**. :* .: * ...****:* *************:***:******************** :.*.* .* * .:** * * *****:******:**.** * ..* :* * *********:*******: :* :******* :*.*****:**::**:.:", "identical_positions": 536, "similar_positions": 182, "identity": "52.45%" }, { "cls_id": "homologset.agr.HGNC:17408", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z0X0-1", "uniprot_id": "BORG3_MOUSE", "id": "Q9Z0X0-1", "name": "Cdc42 effector protein 5", "aln": "MPVMKQLGPAQPKKRLDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEPGAPPVVAPHSVAPP--------------AAPQPPVAVPSPADPLLSFHLDLGPSMLDAVLGVMD----------------AERSETTATKPDGDAHPRVQHPKTRCCSNADLQLDDVIGL-------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6NZY7-1", "uniprot_id": "BORG3_HUMAN", "id": "Q6NZY7-1", "name": "Cdc42 effector protein 5", "aln": "MPVLKQLGPAQPKKRPDRGALSISAPLGDFRHTLHVGRGGDAFGDTSFLSRHGGGPPPEPRAPPAGAPRSPPPP--------------AVPQS--AAPSPADPLLSFHLDLGPSMLDAVLGVMD----------------AARPEAAAAKPDAEPRPGTQPPQARCRPNADLELNDVIGL-------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R2T1-1", "uniprot_id": "F1R2T1_DANRE", "id": "F1R2T1-1", "name": "", "aln": "MPLHKSS------RAPRLDPTMISAPLGDFRHTMHIGRGGDAFGDTSFLSSHGPSSPDPNTAQPVTATPSMTENQDIETNHNDEMKYVEDSSPSELRHSDSVSSFDLDLDLGPSILGDVLGVMDGLTMGSCKGNEEVFTSGSKDAMMSSRNVGNELNERMRMESLSRELRDEQLNEVNGIKSKGLRPKVRFSDKRDEIIGRQEVIEGLEAEGEEMRPNKGMQEISGRTAFDKDPRQEEMVNRREENSPSLSSSASSEYEGVSPLDRRREDQHLSDSDSEEETANGEQGYTFEDELDDEIGL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**: *. : .. ***********:*:************** ** ..* * *. *. * . ... * : . :.:.******:*. ****** . : ::: .: :: . * :*::* *: ", "identical_positions": 54, "similar_positions": 37, "identity": "17.94%" }, { "cls_id": "homologset.agr.HGNC:17409", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0JPL0-1", "uniprot_id": "ZN382_RAT", "id": "A0JPL0-1", "name": "Zinc finger protein 382", "aln": "------------------------MNCHSVPL------QGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERMFPSQSYLED----EEVLVKFRDYQDKPPTSIVIINHKKLIKERNNVYEK--TLGNNHIISKTLFEYKSDGKVLKNISDFISRDINPVMGTLGDSSEWEESVLTSEQEKTHPVPTLYKQIGRNLSSSLELAQHQKTQIPEQRFECDECDSSFLMTEVAFPHDRAHRGVRDFNCSKDEIAFFEKSDLGIHPHNLMEKKCSTYNKYGKLLCRKSVFVMHPRSQVDERPFQCPYCGNSFRRKSYLIEHQRIHTGEKPYICSQCGKAFRQKTALTLHEKTHTDGKPYLCVDCGKSFRQKATLTRHHKTHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCAECGKAFIQKTTLTVHQRTHTGEKPYMCSECGKSFCQKTTLTLHQRIHTGEKPYVCSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECHECGKFFSCKSNLVAHQKTHKAETVRFQ", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "B2RXC5-1", "uniprot_id": "ZN382_MOUSE", "id": "B2RXC5-1", "name": "Zinc finger protein 382", "aln": "MGRPGRKPRGRARPGLFPFPKEELRQGGSSPANLNAMSKGPVSFKDVTVDFTQEEWQRLDPAQKALYRDVMLENYCHFISVGFHITKPDMIRKLEQGEELWTERIFPSQSYLEE----EEVLVKFSDYQDKPPKSIVIIKHKKLIKERSSVYGE--ALGKNRVVSKTLFEYKSDGKVLKNISEFISRDINPAMGKLGGSKEWEGSILTSKQEKTHPASILHKQIGRALSSEWDLAQHQKTQIPEQRFEYNKCDSSFLMTGVEFPHGRAHRGGGNFNYSKDDITLFEKSDLGIHPHDLMEKKCSSYNKYGELLCRKSVFVMHPSSQMDERPFQCPYCGNSFRRKSYLIEHERIHTGEKPYICCQCGRAFRQKTALTLHEKTHTEGKPYLCVDCGKSFRQKATLTRHHKAHTGEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCTECGKAFIQKTTLTVHQRTHTGEKPYICSECGKSFCQKTTLTLHQRIHTGEKPYICSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKIHTGEKPYECQECGKFFSCKSNLITHQKTHKTETMRFQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96SR6-1", "uniprot_id": "ZN382_HUMAN", "id": "Q96SR6-1", "name": "Zinc finger protein 382", "aln": "-----------------------------MPL------QGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFVSVGFHMAKPDMIRKLEQGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLIFINHKKLIKERSNIYGKTFTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEKFGDSTGWEKSLLNTKHEKIHPAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGERTFEYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPYCGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQKTTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILTVHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVHQKTHKVETTGIQ", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * :*.****************:********************:*****::****************:*:*** ****: *:***** :***: . .:::*:********..:* : :**:*:: .. * ***.*********::: *:*.* .:*.*. ** *:*.:::** **. *:** * **.. :* ****.* *** *: ::*:.****. : *.* ***** *: .** *:::***.*.:** :***** *:*****::****.**:* .* :*:**:******.**********:*********:* ***:*************** :***::*:*****************:*********.****** ******************** *************************:*.*************************:*.:**************:***************************** *********::***********:.******.** :*", "identical_positions": 399, "similar_positions": 97, "identity": "68.21%" }, { "cls_id": "homologset.agr.HGNC:17410", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9ESM2-1", "uniprot_id": "HPLN2_RAT", "id": "Q9ESM2-1", "name": "Hyaluronan and proteoglycan link protein 2", "aln": "MPSWIPLPAFCCLLLPWAFTVFHKTLGNPAPHPGPHYLLPPIHEVIHSRRGATATLPCVLGTSPPSYKVRWSKVEPGE-LRETLILITNGLHARDYGLLGGRASLRRGHRLDASLIIKNVRLEDEGRYRCELINGIEDESVALTLRLEGVVFPYQPSRGRYQFNYFEAKRACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLNARAPCGGHGRPGIRSYGPRDRSRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAVCRRRGAVVAKVGHLYAAWKFSGLDRCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ESM3-1", "uniprot_id": "HPLN2_MOUSE", "id": "Q9ESM3-1", "name": "Hyaluronan and proteoglycan link protein 2", "aln": "MPSRIPLPAFCCFLLPWAFTSFHKALGNPAPHPGPHYLLPPIHEVIHSRRGATATLPCVLGTSPPSYKVRWSKVEPGE-LRETLILITNGLHARDYGLLGGRASLRRGHRLDASLIIKNVRLEDEGRYRCELINGIEDESVALTLRLEGVVFPYQPSRGRYQFNYFEAKRACEEQDGRLATYGQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGHGRPGIRSYGPRDRSRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQASYGTYCYAEK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9GZV7-1", "uniprot_id": "HPLN2_HUMAN", "id": "Q9GZV7-1", "name": "Hyaluronan and proteoglycan link protein 2", "aln": "MPGWLTLPTLCRFLL-WAFTIFHKAQGDPASHPGPHYLLPPIHEVIHSHRGATATLPCVLGTTPPSYKVRWSKVEPGE-LRETLILITNGLHARGYGPLGGRARMRRGHRLDASLVIAGVRLEDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYYEAKQACEEQDGRLATYSQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGPRDRMRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEN", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NDB5-1", "uniprot_id": "A0A8M1NDB5_DANRE", "id": "A0A8M1NDB5-1", "name": "", "aln": "-MNFIALLLTSTCFFSCINAKYHYNQDK--DKELKYLLEPLVFAEVSARRGHAAILPCVMRFKPSHYRVKWTKLEPSSRGVENIVLITNGHADKQYGSVGPRAALQRAHDLDVSLRLSDLELEDDGSYRCELINGIEDESVIITLRIEGVVFPYQSQKGRYRFTFFDAKEACAEQDATLATYKQLYRAWTEGLDWCNAGWLIDGTVSYPVLHPRPACGGDLLSGIRSYGPRHKTRENYDAFCFTSTTKGSVFFIEGQLNFAEAERACRRDGAGLAKTGQIYSSWRFQQLDRCDGGWLEDGSVRFPIINPREHCGGIAEPGVRSFGFPSKSMRLYGAYCYR--", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :.* . :: : :* .. : : * * :. : ::** :* ****: .*. *:*:*:*:**.. *.::***** : ** :* ** ::*.* **.** : .:.***:* ************** :** :********..:***:*.:::**.** ***. **** ***:**************::*:* **** .*..*** .********.: *:.********: *.***: *:*.::**. .*** ** :**.*::*::*:*. **:****** ******** .** :***:.:********* . **:*** ", "identical_positions": 176, "similar_positions": 90, "identity": "51.46%" }, { "cls_id": "homologset.agr.HGNC:17412", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9QZM3-1", "uniprot_id": "CLCF1_MOUSE", "id": "Q9QZM3-1", "name": "Cardiotrophin-like cytokine factor 1", "aln": "-----MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPG-PGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETL--PRATVNLEVWRSLNDRLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMATLGYP-LP-------------------------------------------------------------------------------------------------------------------------------QPLPGTEPAWAPG-----------------------------------------PAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAASVTLHLEAHGF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F7EKG3-1", "uniprot_id": "F7EKG3_RAT", "id": "F7EKG3-1", "name": "Cardiotrophin-like cytokine factor 1", "aln": "MQPTAWEPEAGDSWGMLACLCTVLWHLPAVPALNRTGDPG-PGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETL--PRATVNLEVWRSLNDRLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMATLGYP-LP-------------------------------------------------------------------------------------------------------------------------------QPLPGTEPAWAPG-----------------------------------------PAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAASVTLHLEAHGF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UBD9-1", "uniprot_id": "CLCF1_HUMAN", "id": "Q9UBD9-1", "name": "Cardiotrophin-like cytokine factor 1", "aln": "-----MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPG-PGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETL--PRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYP-LP-------------------------------------------------------------------------------------------------------------------------------QPLPGTEPTWTPG-----------------------------------------PAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6T6-1", "uniprot_id": "A0ACD6B6T6_DANRE", "id": "A0ACD6B6T6-1", "name": "Cardiotrophin-like cytokine factor 1", "aln": "--------MCPWKVGQVAVLLLLAVMVGNAQVLDRTLILSNERSSIERTYELTKYLDHQLKEIRDTYLSYLGPPFSHPGFSPPRPNSSSLSVPSAATRVDLWRGLENGARLAQNQHAYSILLCAVRELARSTLCPYLQSSLLHFCSGLSGLLGSISGLMNALGYTNLPSSAGYATPAQGYAPAMSSQFQGVSENSPAPLRSYVPRNQGAKTVSGVREGTTRADLKRDREKERAERGRRGRRKEGESWVAKEEGEKEEGMERWGKRRRLLSMDEEKTIKLNNMNYTSLKFGDGYRKQPLLFSTPSLHPRRSVRSIPSSHSGLSPLSLLYQYGGPVSEVHTLLAAPVLSSHPTANDFSRKVEGFWVLRELQSWLWRSAKDFTRLKKRLRV--------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . * :* * : : . .*:** . .**::**:**:**:***:.: .***.******..*.*.*** .:.:* * *:. :::**.*:: **:** .*** *** :* * *.: . *: ** ***:.*.******:*:* :***. ** *** : *: * *: .** :*::.**:*:***:*********.****::: ", "identical_positions": 98, "similar_positions": 65, "identity": "24.38%" }, { "cls_id": "homologset.agr.HGNC:17416", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A096MK89-1", "uniprot_id": "A0A096MK89_RAT", "id": "A0A096MK89-1", "name": "Adhesion G-protein coupled receptor V1", "aln": "MSVTSEPGMVSSLLLV-YLSALVVSFVCG-EAEIRFTGQTEFFVNETSTTVIRFVIERIGEPANVTAIVSLDGEDTGDFFDTYAAAFIPAGGTNRTVYIAVCDDDLPEPDETFTFQLTLQKPSANVKLGWPRAAAVTILSNDNAFGVISFSTPSSITVTEPRSRNASVSLTLIREKGTYGMVTVTFDVSGGSNPPEEDLSPVRGNITFPPGRATIIHNLTVLDDEVPENDEMFLIQLRSVGGGAEINASRSSVEIIVKKNDSPVKFLQSVYVVPEDDHVLTIPVVRGKDNNGHPIGSDESQVSVRYKVVTGDSTAHAQQNVDFIDLQPDTTLVFPPFVHESHLKFQIIDDLIPEIAESFHIMLLKNTLQGDAVLMDPSTVQVTIKANDKPHGVLSFNSILFERPVVIDEDTASSSRFEEITVVRNGGTHGNVSVNWVLTRNSSDPSPVTADLSPASGTLQFAQGQMLALIPLAIIDDELPEEAEAYLLTILPHTIQGGAEVSEPAQLLFYVQDSDDVYGEIALFPVESQRIESSPSERSLSLSFTRLGGSKGDLKVIYSALYIPAGAVDPLRAKDGILNTSRRNTLLFPEQNYQVTAKLPIRNDAFLQNGAHFLVQLEAVELVNIVPLIPPVSPRFGEIRNTSLLVTPAIANGEIGFLSNLPIILHEPNDSAAEVVSIPLHRDGTDGQATVYWSLRPSGFNSKAVTVDDTGPFNGSVVFLSGQSDTSINITVKGDDTPELNETVTLSLDRVSVDSDVLKSGYTSRDLIILENDDPGGIFEFSYDSRGPYVIKEGDAVELRIARSRGALVKQFLRFHVEPRDSNEFYGNTGVLEFSPGEREVVITLLTRLDGMPELDEHYWVVLSSHGGRESKLGSATHVNITILENDDPHGIIEFASNGLTVSIRESKGEDVYHAVYG-VVRTRGNFGAVNVSWMVSPNSTQDVFPVQGTVCFGDQENFKNITVYSFADEIPEEMEEFTIILLSATGGAQTGNQTTASLRILRNDDPIYFAEPSVVRVQEGETANFTVLRNGSVDAACTVQYATVDGKASGGEGDFVPVEKGETLVFEVGSREQSVSVSVNEDGVPETDEPFYIILFNSTGDTVVYEYGVATIIIEANDDPNGVFSLEPIDKAVEEGKTNAFWILRHRGHFGNVSVAWHLFQN-ASLQPGREFYETSGTVNFTDGEGTKPVILRAFPDRIPEFNEFYILRLVNISG----AGGQLAETDLQVTVMIPFNDDPFGVFILDPECLEREVAEDVLSEDDMSYIANFTVLRQQGVFGDVRVGWEVLSRELPAGLPPMVDFLLVGVFPSTVPLQPHMRHRHSGTDVLYFSGLEGAFGTVDPKYQPSRNNTIANFTFSAWVMPNAYTNGFLIAKDDSHGSIYYGVKIQTNETHVTLSLHYKTFGSDVTYIAKSTAMKYLEDGVWLHVLIILDDGIIEFYLDGNAMPKGIKSLKGEAITDGPGILRIGAGMDGGDRFTGWMQDVRTYERKLTPEEIYELHAMPARNDLHPISGYLEFRQGETNKSFIVAARDDSEEEGEELFLLKLVSVYGGAQLSEENTTARLRIQKSDNANGLFGFTGACIPEMTEEGSTVSCVVERTRGALGYVRVFYTISQIESEGLHYLVDDFANASGTITFLPWQRSEVLNLYVLDENIPELNEYFRVTLVSAVPGDGKLGSTPVSGASIDPEKETTDITVKASDHPYGLLQFSTGLPPQPEDAMSLPASSVPHITVQEEDGEIRLLVVRAQGLLGRVTVGFRTVSLTAFSPGDYQSIAGTLEFQSGERYKYIFVNITDNSVPELEKSFKVELLNLDGGVSELFRVDGSGSGEGDTDFFLPAVRMHAS-LGVASQILVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVVLNVTRAQGALSPVTLLWKVDSDPDGDLAVTSGNITFEVGQRLAHITVEILADEEPELDKTRTVSILNVSSGSLGVLSSATLTILASDDPHGVFIFPNKTRPISVEEATQNVTLSIIRLKGLMGEVAISYATIDDMEKPPYFPPNLARATQGGDYISASGLALFRANQTEAMITISILDDDEPERSESVFIELFNSSLVDKVQNRPIPHSPRLGPKVETVAHLIIVANDDAFGTVQLSAPTVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAATGEDYSIASSDVVLLEGETTKAVPIYIIDDIYPELEEAFLVQLLNETTGGATLGPLREAVITIDASDDPFGLFGFQNTKFIVEEPEFNSVWVNMPIIRNSGTLGNVTVEWVATINGQLATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQLAAASGGGTIGLDRVAHIVIAANDNPYGSVAFAQSIYRVQEPLQRHSSANITVRRSGGHYGRLLLFYSTSDIDVVALAVEEGEEDVLSYYESPTQGMPDPLWRTWVNVSAVEETQYTCATLCLREHACSAFSVVSGADGPQCFWMTSWVSLTVNSSDFQTYKKNMTKVASLFSGQAVAGSDYEPVTRQWALMPEGDEFANLTVSLLPDDVPEMDECFLISLLEVHLVNITDSFKNQPTIGHPSTSTVLIGLNGDAFGVFVMYSVSPNTSEDGLCVQVQEQPQTSVELVIHRTGGSLGQVMVEWRTVGGTATEGLDFIGAGDILTFAEGETKKTAILTILDDSEPEDEESIFVRLVATEGGSRILPSSDTVTVNILANDNVAGIVSFQTASRSVIGHEGEMLQLHAVRTAPGRGNVTVNWKVTGQNLEVNFANSTGQLFFSEGALNKTIFVHLLDDNIPEEKEVYQVVLYDVKTQGVSPAGVALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVVLPEANLTVQLFVNREFGSLGAINVSYATVPGIASLKNETEGNLAEPEADFIPVVGFLVLEEGETTAAINITVLEDDIPELREYFLVNLTHVDLVMAPLTSFPPRLDSEGLSAQIVIDANDGGQGVIEWQRSRLEVNETHGTVTLVVQRGRAALGHVSLFMYAQNLEAQMGLDYMCTPQILHFADGERFKPVDVVILDDDVPEGDERFQLILTNPSPGLELGTNTIALITVLANDDGPGVLSFNNSGHVFLREPTSLY-VQESVAALVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLVPSKGFIVLEEGVRSKALHISAVLDTEPEMDEHFVCTLFNPTGGARLGAHVQTVITVLQNQAPLGLFSIS-AVENSATSIDVEESNRTVYLNVSRTNGLDLAVSVQWETVSETAFGMRGMDVVFSIFQSFFDKTALDWCFFSVGDSVYGVMLRK----SSLVVYRWQGTFVPVEDLNVESPRTCEAFTIGVSLYLVITHGERNGEKPSINSVYTLASGFRLLLVQTIVISGSCQVRHFTSDTQDYFIIASQRNDSELTQVFRWNGNNFAWHQTLPVRGVLGMALFSRGGS--VFLAISQANIRQNPLLFMWSGSQFINFQELSVS-GITQVEALSSGDDVYLFFAKNTFLGNQNAIDIFVWEMGQSSLRHFQSLDFATVNRIRSFTPASGIVHILLTGQDRSALYCWNSELNAFTFVLEAPSAHDAAFVTVKSLNSSKTLIALVGATDTHVYELAYVSSQSDFIPSLGELMFEPGDREAIIAVSVLDDAVPEEEESFRVQLKNPRGGAEIGTDSSVRVTVRPNDDPYGVVAFAQNSLHKQLEELERDSLVTLNVERLKGTYGRVTVAWEAAGSVSDVFPTSGVISFAEDQAMSTITLTVLADDLPELSEAVVVTLTRIVTEGVEDPSKGATIDQDRSKSVLTILPSDSPYGVVGWHAESLFTRVPEPRENITVLQLHLVRDKGLLGDISIHLIAKPNFLLDINNQATENEDFALQDSVIIMKENIKETQAEVAILPDEVPELDEGLIVAIAAVNLVNPNFPAEQPRVQRPRMESAEIMIEENDDPRGIFSFRVSRGVGGVIIAHEGPQPLNILQVPVIRMAGSFETVNVYWKATPDSAGLEDFLPPYGMLQFADGQVIAPIHITITDDTEFELSETFSISLMSVTGGGRLGDDVLVTVVIPPNDSPFGIFGFEEKTVMVDRSHLSDDPDSYVKLTVVRSPGGKGAVRLHWTIEEKAKDDLSPLNGTLYFDETDSQKSIILHILQDSVLGEDRRFTIELMD-AGEVEISPGKGRASVIILGEKSPS-EVGIASSSRHVIIGEPSATYSGTATISLDRGPGVSGEVTVDWRILPPSRGEFAETSGQLTMLDGQSTATVVIQALDDGIPEEKCSYEFQLTGISEGAVLNEASVTASISMVASDAPYGQFSFSHEQLQVSEAAQKVNVTVARSGGSFGRVRVWYETGSRTAEAGWDFVPTSGELIFEAREKMKSLHIEILDDNLPEGPEEFVLAITRVDLQ-GRGYDFTIQENGLQIDQPPEIGSISVVQIIIMENDNVEGIIEFDPKFTDISVEEGAGVIPLPVMRLRGTYGRVSADFSSRDSSAVPG--GYVLHGGSVTFQHGQSLSFINVSIVDDNDSESEKQLEILLIGATGGAILGRHLVSKITIAKSDSPFGIIRFLNQSKISVPNPNSTMALHLVLERTGGLLGEIQVSWEIVGPSSEELLLPQHGDFADPVSGTVSFGDGEGGVRTITLTVCPHEETEAEETFVVQLKPLK-EAKLDPRAKAVTLTIQKFGDPNGVIHFAPESLSKKMFSEPPPSEGPMLISFLVTRSKGTSGEITVHWELSSEFDLTGDFLSTQGFFTIADGDSEASFDVHLLPDDVPEIEEEYVVQLVSVEGGAELDLEKCTSRFSVSANDDPHGIFALYSDQQSVLIGQN-LIRSIQINITRLAGVFGAVAVTLQILSDNKEDPVATENEERQMVIKDGARYKVGLVPLKNQVFLSLGSNFTLRLLSARLLSGPFYGMPTIHQEANQAFLSVPEEAANSQVGFESTAFQLIDITAGTSQVTVSRRGTYGRLSVAWTTGYAPGSEIPEPIAIGNMTPTLGSLSFLHGEQKKGVLLWTFPSPGQPEAFVLHLSGLRSSAAGGAQLRSAFTTAEIEPLGVFQLSPGSRNITVSEDALIIRICVQRLFGFQGDLIKVSYKTTAGSAKPLEDFEPIQKGEIFFQRFQAEVDFEITIINDQLPEREETFYINLTSVETRGPGKGDVSWRPRLNPDLSVAMVTILDNDDPAGVAVSVPVTAGTVAADSTLLAMEADFTTHPNKSKITTIPYTTEVFAPVTETVDVSAIPEKLVTIH--SAISEEPDLAPGTAQAAVFGTLSLGPPIVYVSEEMKNNTPS-TADIQIQRIGGFAGNVSVTVRTFGGRCAQKEPSVWPFQDVYGIGNLT-WAVEEEDFEEQMLTLTFLNGEREHRIAVRILDDDEPEGQEFFYVFLTDPQGGAEIVRGKDGSGFSAFALILITGSDLHNGIVGFSEESLRGLELREGTDKSSQRLEVTRQPNRAFEEVQVFWRVTLNQTATILQEKGLNLTDELRSVAGVTTCTVGQTQCFIHLELNPKKVHQVEMPFFVELYDVTAGAAINNSARFARIKVSKSGDSQSLVFFSVGSRLAVAHKKATLISLQVARDSGTGMMMSVNFSTQELRSAETVGRILLSPAVSGKDFVRTEGTLVFEPGQKSAVLDVVLTPETGSLNKFPKRFQIVLFDPKGGARIDKVYGTANITLVSDVDSQAVWGLEDLLHQPLHEDVLNRVLHSLNLRVATESTDEQLSAVMFIMEKIMMEGKNQAFSIESRTLLYELLCALINPKRKDTRGFSHFAEVAEHFAFSLLTDVTCGSPGEKSKTILDSCPYLSILALHWSPQQINGHRFEGKEGDYIQIPERFLDAPEP-EVSDGKNACALVQFVEYSSQQWFVAGDNLPALRDKVLSLNVKGRDAQPLPNNNEVLYRIYAAEPR--IIPHTSLCLLWNQAASSWLSDSQLCKVVEDAADYVECACSHMSAYAVYAQTDNLVSYNEAFFSAGFICISGLCLAVVSHVFCARYSMFAAKLLTHMMAASLGAQVSFLASAYASPQLSEESCSAVAAVAHYLYLCQFSWMLIQSVNFWYVLVVNDEHTERRCLLFCLLSWGLPSFVVILLIVILRGIYHQSMPQIYGLIHGDLCFIPNIYAALFTAALVPLMCLVVVFVVFIHAYQLKPQWKGYDDVFRGRTNAAEIPLILYLFALISLTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFVVYFILHNQTCCPMKASYTVEMNGHPGPSTAFFTPGSGIPPAG-EMNKSTQNLINAMEEVPSDWERVSFQQTSQASPDLKTSPQNGASFPSSGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIPIADTHL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8VHN7-1", "uniprot_id": "AGRV1_MOUSE", "id": "Q8VHN7-1", "name": "Adhesion G protein-coupled receptor V1", "aln": "MSVTSEPGMISSFLLV-YLSTLFISFVFG-EAEIRFTGQTEFFVNETSTTVIRLVIERIGEPANVTAIVSLSGEDTGDFFDTYAAAFIPARGTNRTVYIAVCDDDLPEPDETFTFHLTLQKPSANVKLGWPRAASVTILSNDNAFGIISFSTPSSISVIEPRSRNASVPLTLIREKGTYGMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDDEVPENDELFLIQLRSVEGGAEINASRSSVEIIVKKNDSPVNFMQSVYVVPEDDHVLTIPVLRGKDSDGNLIGSDETQVSIRYKVMTWDSTAHAQQNVDFIDLQPDTTLVFPPFVHESHLKFQIIDDLIPEIAESFHIMLLKNTLQGDAVLMGPSTVQVTIKPNDKPYGVLSFNSILFERPVIIDEDTASSSRFEEIAVVRNGGTHGNVSVSWVLTRNSSDPSPVTADITPASGTLQFAQGQMLAPISLVVFDDDLPEEAEAYLLTILPHTIQGGAEVSEPAQLLFYIQDSDNVYGEIAFFPGESQKIESSPSERSLSLSLARRGGSKGDVRVIYSALYIPAGAMDPLRAKDGILNTSRRSSLLFPEQNQQVSIKLPIRNDAFLQNGAHFLVQLEAVVLVNIFPPIPPVSPRFGEIRNISLLVTPAIANGEIGFLSNLPIILHEPKDSSAEVVSIPLHRDGTDGQATVYWSLRPSGFNSKAVTLDDAGPFNGSVVFLSGQNETSINITVKGDDIPELNETVTLSLDRVSVDSDVLKSGYTSRDLIILENDDPGGIFEFSYDSRGPYVIKEGDAVELRITRSRGSLVKQFLRFHVEPRESNEFYGNMGVLEFTPGEREVVITLLTRLDGTPELDEHFWVILSSHGERESKLGRATLVNITILKNDYPHGIIEFVSDGLSASIKESKGEDIYHAVYG-VIRTRGNFGAVNVSWMVSPDFTQDVFPVQGTVCFGDQEFFKNITVYSLVDEIPEEMEEFTIILLNATGGAQTGIRTTASLRILRNDDPVYFAEPCVLRVQEGETANFTVLRNGSVDGACTVQYATVDGKASGEEGDFAPVEKGETLVFEVGSREQSISVHVKDDGIPETDEPFYIVLFNSTGDTVVYEYGVATVIIEANDDPNGVFSLEPIDKAVEEGKTNAFWILRHRGHFGNVSVAWQLFQN-ASLQPGQEFYETSGTVNFTDGEETKPVILRAFPDRIPEFNEFYILRLVNISG----PGGQLAETNFQVTVMIPFNDDPFGIFILDPECLEREVAEDVLSEDDMSYITSFTILRQQGVFGDVRVGWEVLSREFTAGLPPMIDFILLGSFPSTVPLQPHMRRHHSGTDVLYFSGLEGAFGTVDPKYQPFRNNTIANFTFSAWVMPNANTNGFLIAKDDSHGSIYYGVKIQTNETHVTLSLHYKTFGSNVTYIAKSTVMKYLEEGVWLHVLIILDDGIIEFYLDGKAMPRGIKSLKGEAITDGPGILRIGAGMDGGARFTGWMQDVRTYERKLTPEEIYELHAVPARTDLHPISGYLEFRQGESNKSFIVAARDDSEEEGEELFLLKLVSVDGGAQISKENTTARLRIQKSDNANGLFGFTGACIPEMTEEGSTVSCVVERTRGALGYVHVFYTISQIESEGINYLVDDFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVTLVSAVPGDGKLGSTPISGASIDPEKETTGITVKASDHPYGLMQFSTGLPPQPEDSMSLPASSVPHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVELLNLDGGVSDLFRVDGSGSGEADTDFFLPPVLPHAS-LGVASQILVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVVLNVTRTRGALSAVTLQWKVDSDLDGDLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSILNVSSGSLGVLTNATLTILASDDPYGVFIFPNKTRPLSVEEATQNVALSIIRLKGLMGEVAVSYATIDDMEKPPYFPPNLARATQGGDYISASGLALFRVNQTEATITISILDDAEPERSESVFIELFNSSLVDKVQNRPIPHSPRLGPKVETVAHLVIVANDDAFGTVQLSATSVHVAENHVGPIINVTRTGGTFADVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQLLNETTGGATLGPLREAVITIEASDDPYGLFGFQNTKFIVEEPEFNSVRVNVPIIRNSGTLGNVTVQWVAIINGQFATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQLAAASGGGTIGLDRVANIVIPANDNPYGSVAFVQSVFRVQEPLERSSYANITVRRSGGHFGRLLLCYGTSDIDVVARAVEEGE-DVLSYYESPTQGVPDPLWRTWVNVSAVEETQYTCATLCLKERACSAFSVVSGAEGPRCFWMTSWVSGTVNSSDFQTYKKNMTRVASLFSGQAVAGSDYEPVTRQWAVILEGDEFANLTVSVLPDDAPEMDESFLISLLEVHLMNISDSFKNQPTIGHPNTSAVVIGLNGDAFGVFIIYSVSPNTSEDGLCVEVQEQPQTSVELVIYRTGGSLGQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRLGATEGGSRILPSSDTVTVNILANDNVAGIVSFQTASRSVIGHEGEMLQFHVVRTPPGRGNVTVNWKVVGQNLEVNFANFTGQLFFSEGTLNKTIFVHLLDDNIPEEKEVYQVVLYDVKTQGVSPAGVALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVVLQEANVTIQLFVNREFGSLGAINVTYATVPGIVSLKNNTEGNLAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNLTHVDLIMAPLTSSPPRLDSEGLTAQIVIDANDGAQGMIEWQRNRFEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGLDYMRTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLTNPSPGLELGKNTIALITVLANDDGPGVLSFNNSGHIFLREPTSLY-VQESVAVLVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLSPSKGFIVLEEGVRSKTLRISAILDTEPEMDEHFVCTLFNPTGGARLGAHVQTLITIFQNQAPLGLFSIS-AVENSATSIDVEESNRSVYLNVSRTNGLDLTASVQWETVSETAFGMRGMDVVFSIFQSFFDKTALDWCFFTVEGSVYGVMLRK----SSLVVYRWQGTFVPVEDLKVESPKTCEAFNIGVSPYLVITHGERSGEKPSINSVYMLTAGFRLVLIQTIIISGSCQVRHFTSDSQDYFIIASRRNDSELTQVFRWNGNNFAWHQTLPVRGVLGMALFSRGGS--VFLAISQANIRQTSLLFTWSGTQFINFQELPIS-GITQVEALSSGDDVYLCFAKNTFLGNQNAIDIFVWEMGHSSLRYFQSLDFAAVKRIRSFTPASGIVHILLTAQDGSALYCWNSELNAFSFVLEAPAAHDAAFVTVKSLNSSKTLIALVGATDSHLYELTYVSSQSDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQLKSPRGGAEIGINSSVRVTVLANDGAYGVVAFAQNSLHKQLEELERDSLVTLNVERLRGTHGRITVAWEAAGSVSDVFPTSGVISFTEDQAMSMITLTVLADDLPELSEAVVVTLTQIVTEGVEDPLKGATIDQSRSRSVLTILPSDSPYGAVRWHTESLFNRVPEPTENITVVQLHIVRDKGLFGDISIHLIAKPNFLLHINNQATEDEDFVLQDSVIIMKENIKETHAEVAILPDEVPELDEGLIVTIAAVNLVNPNFPAEQPRVQRPRMESAEILIEENDDPRGIFNFHVVRDVGGVIIAHEGPPPLNVLQVPVVRMAGTFETVNVYWKATPDSAGLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISLVSVTGGGRLGDDVSVNVVIAPNDSPFGIFGFEKKTVMVDGPLLSDDPDSYVTLTVVRSPGGKGAVRLHWAIEEKAKDDLSPLNGTLYFDETESQKSVILHTLKDGMVGEDRRFIIELTA-ADEVEISPVKGSASVIIRGDKSIS-EVGIASSSRHIIIGEPSATYNGTAIIDLVRGPGVSGEITVNWKILPPSRGEFVETSGQLTMLDGQTAATVVIQVLNDDIPEEKCHYEFQLTEISEGRMLHEASVSARITMVASDAPYGRFSFSHEQLHVSKAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDDLPEGPEEFVLAITRVDLQ-GRGYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTDISVEEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPG--GYVLRGSSVTFQHGQNLSFINVSIIDDNGSEFEKQFEILLIGATGGAILGRHLVSKITIAKSDSPFGIIRFLNQSKISLPNPSSTMALHLVLERTGGLLGEIQVSWEVVGPDAEEPLPPHNGDFADPVSGTVSFGDGEGGVRSIILRVCPHEETEAEETFIVQLKPLR-EAKLDPRAKAVTLTIQKFGDPNGVIHFAPESLSKRRFSEPPPSDGPLLVSFLVTRSKGTSGDIKVHWELSSEFDITRDFLSTRGFFTIADGESDANFDVHLLPDDVPEIEEEYAVQLVSVEGGAELDLGKCTARFSVSANDDPHGVFALYSDRQSVLIGQN-LDRSIQINITRLAGAFGAVAVRVQILSDNKEDPVATENEERQLVITDGARYKVGLVPLKNQVFLSLGSNFTLQLVSVRLLSGPFYGIPTILQEAKNAILSVPEEAANSQVGFESAAFQLMDIKAGTSQVMVSRKGTYGRLSVAWTTGYAPGSEIPEPIVIGNMTPTLGSLSFVHGEERKGVLLWTFPSPGRPEAFVLHLSGLRSSAAGGAQLRSGFTTAEIEPMGVFQFSPSSRNITVSEDAQTIRICVQRLFGFHGDLIKVSYETTAGSAKPPEDFEAVQKGEVFFQRFQPEIDFEITIINDQLPEIEETYYINLTSVETRGLGKGGVNWRPRLNPDLSVAVVTIVDNDDLTGAAVSVPVTAGTVAVDSTLLAMETGSTTHPNKSKITTIPYTTEVFAPVTETVTVSAIPEKLATAH--SVISVKPDVVPGTVVASVYGTLSIGPPIVYVSEEMKNGTLS-TADILIQRMGGFAGNVTITVKTFGGRCAQKEPSVWPFQDVYGVGNLTTWAVEEEDFEEQLLTLTFLYGERERKIAVQILDDDDAEGQEFFYVFLTDPQGGAEIVRGKDSTGFSAFAVIIISGSDLHNGIIGFSEESQRGLELREGADKNSQRLVVTRQPNRAFEEVQIFWRVTLNQTVTILQEKGANLTDELRFVAGVTTCTGGQTRCFIHLELNPKKVHQVEMPFFVELYDVTAGAAINNSARFAPIKLSKSGAPQSLVSFSVGSRLAVAHKKSTLISLQVARDSGTGIMMSVNFITQELRSAETVGRVLISPAVSGKDFVRTEGTLVFEPGQKSAVLDVVLTPEAGSLNKFPKRFQIVLFDPKGGARIDKVYGTANITLISDADSQAVWGLEDLLHRPLHEDILNRVLHNLNLRVATESTDEQLSAVMLIMEKITMEGRNQAFSIKSRTLLYELLCVLINPKRKDTRGFSHFVEVAEHFAFSLLTDVTCGSPGEKSKTILDSCPYLSILALHWNPQQINGHKFEGKEGDYIQIPERLLDVPEA-EMLDGKNACTLVQFVEYSSQQWFIAGDNLPALKDKVLSLNVKGQSAQPLPNNNEVLYRIHAAEPR--VVPHTSRCLLWNQAAASWLSDSQFCKVVEDASDYVECACSHMSVYAVYAQTDNSSSYNEAFFSAGLICISGLCLAVVSHMFCARHSMFAAKLLTHMMVASLGTQILFLASAYASPHLSEESCSAVAAVAHYLYLCQFSWMLIQSVNFWYVLVVSDEHTERRCLLFCLLSWGLPSFVVILLILILRGIYHRSMPQIYGLIHGDLCFIPNIYAALFTAALVPLMCLVVVFVVFIHAYQLKPQWKGYDDVFRGRTNAAEIPLILYLFALISMTWLWGGLHMAYGHFWMLVLFVIFNSLQGLYVFVVYFILHNQTCCPMKASYTVEMNGHPGPSTAFFTPGSGIPPAG-EINKSTQNLINAMEEVPSDWERSSFQQTSQASPDLKTSPQNGASFPSSGGYGPGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIPIADTHL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WXG9-1", "uniprot_id": "AGRV1_HUMAN", "id": "Q8WXG9-1", "name": "Adhesion G protein-coupled receptor V1", "aln": "MSVFLGPGMPSASLLVNLLSALLILFVFG-ETEIRFTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVKLGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAEINTSRNSIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRIS--RYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILPHTIRGGAEVSEPAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRNDAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANGEIGFLSNLPIILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSGYTSRDLIILENDDPGGVFEFSPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVMINESKGDAIYSAVYD-VVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRNDDPIYFAEPRVVRVQEGETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYIILLNSTGDTVVYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLEREVAEDVLSEDDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMIDFLLVGIFPTTVHLQQHMRRHHSGTDALYFTGLEGAFGTVNPKYHPSRNNTIANFTFSAWVMPNANTNGFIIAKDDGNGSIYYGVKIQTNESHVTLSLHYKTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYLDGNAMPRGIKSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHAMPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEENTTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRAS-LGVASQILVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHWNIDSDPDGDLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGPKVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGGARLGALTEAVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLGNVTVQWVATINGQLATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANIIIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALAMEEGQ-DLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACSAFSFFSASEGPQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDNVAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELNFANFSGQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPAGIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQEANITIQLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLELGKNTIALIIVLANDDGPGVLSFNNSEHFFLREPTALY-VQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNPTGGARLGVHVQTLITVLQNQAPLGLFSIS-AVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWETVSETAFGMRGMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRK----SSVTVYRWQGIFIPVEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLFLVQTIIILESSQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQKLPVRGVLTVALFNKGGS--VFLAISQANARLNSLLFRWSGSGFINFQEVPVS-GTTEVEALSSANDIYLIFAENVFLGDQNSIDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFSFVLEVPSAYDVASVTVKSLNSSKNLIALVGAHS-HIYELAYISSHSDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTLTRITTEGVEDSYKGATIDQDRSKSVITTLPNDSPFGLVGWRAASVFIRVAEPKENTTTLQLQIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKASPDSAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLIS-IDEVEISPVKGSASIIIRGDKRASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGEFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVVASDSPYGRFAFSHEQLRVS-EAQRVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQ-GRGYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRHLVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPNSQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEIMVYWELSSEFDITEDFLSTSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAELDLEKSITWFSVYANDDPHGVFALYSDRQSILIGQN-LIRSIQINITRLAGTFGDVAVGLRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVGGRFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNITAGTSHVMISRRGTYGALSVAWTTGYAPGLEIPEFIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEAFVLHLSGVQSSAPGGAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRGLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTLIPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPAVSEKPDVATVTANVSIHGTFSLGPSIVYIEEEMKNGTFN-TAEVLIRRTGGFTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLT-WAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTGFAAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRAFEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISIELKPEKVPQVEVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYFSVGSRLAVAHKKATLISLQVARDSGTGLMMSVNFSTQELRSAETIGRTIISPAISGKDFVITEGTLVFEPGQRSTVLDVILTPETGSLNSFPKRFQIVLFDPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVNDDILNRVLHTISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLINPKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILALHWYPQQINGHKFEGKEGDYIRIPERLLDVQDA-EIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPR--IIPQTSLCLLWNQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGHPGPSTAFFTPGSGMPPAGGEISKSTQNLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPSSGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIPIADTHL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6JAN0-1", "uniprot_id": "AGRV1_DANRE", "id": "Q6JAN0-1", "name": "Adhesion G protein-coupled receptor V1", "aln": "--------MPAVLALSGLLLMLLTVSVRSESAELRFQGQTQFVVNESSRAIVRLVVERVGDPINVTALVLLQGDDTGDFEATTAAAFLLSSESSKTIFIAVKDDDIPEADETFVFILRLQSSSNGVTVGTPNTATITILSNDNAFGIISFNSSSLITVEESKGRSQYVPLTLLREKGTYGTVTVNFEIFGGPNPASEDLSPDMGNITFPPGRSVVVFSIMIQDDKLPEDDEIFTVQLTEAAGGALLNPNRSSVQIKISRNDAPIRFSKSTLVVPENIGVISLTVTRGRTEDGLLIGSDDKTVSVAYAIITGNGAASATPLTDFVDLQTERMVVFLPGVHEADLRFSIRDDNIPEIAESFQVVLLEETLLGDAVLVTPSLTLVTIEPNDKPYGVLSISPSPIQPHIINED---LNLIYEGMIIVRNGGTHGAVSVQWNITRNSTDRSPVSADLNPAAGTLRFSEGQMSAVLPLNITQDSLPEEAEAFLLKLIPGSVQGGAEVDEPMEMVFFIQDSDDVYGRFGFHPRENQSIQSQPEGRFLSLSFLREGGTLGEVRLTLTALYIPARPLDPSRARDGVLNGTSVNTVLFSSGQSRAQLILPIRNDAFLQNGAHFRIQLDSVELVNITPPIPSMSPRFAGALNISLIITPDIANGEIGFTSNQTVVALEPEDSNSSLITLQLRRDGTDGQAVVFWSLRPTGENKEDVTKGDISPFTGSVTFLSGQSEAVINLTVLADNIPEINETIILTLDRTNVDNQILKPGFTSREIVILENDDPGGVFEFSPVSKGPWFINEGETVELRVIRAQGQLLNQLIRYTVIPSGTAQFYGATGILEFQPGEREVMVALVAKPDGIPELDETFSVVLSSYSTPASRLGNRREVNITVRKSDDPFGVIEFIQPDLDFTINESKALGCLLSILPPLEKSRGRFGNVSIFWILEPTYSGDVKPVQGEIVFAEGEYQKNLTLSSVADEIPEKTENFTITLLNATGGARLGNILSARLSIRANDDPIYFAEPVGQRVREGGVANFTILRAGLANFVTTVNYRFEYGDTSSE--DFIPESNDTMLVFHFGEWMKNISVAVVDDNIPETDEPFYIVLFNATGDAVVYGQITATVVIEANDDANGIFSLDSAQKPGEEGKTNNFYVLRDRGHFGNVTIYWQLFANDTPLEPYQEFVNTSGFITFRTGEKTKPIVLEVISDKLPEFNEFYELRLMNVSGGYPGEGGKLANRDLNASVLIPFNDDPFGVFAIAPDSLEREVAEDVLSVNDMTSVTSLTILRQQGTFGDVRVAWEILSGAFPRGLPPMEDLILMASFPSAVELQPHSRRRHAGTDALFFSGRPGAYGSISAETTLLVPQILANFTLSVWLKPKPNTDGFVVSKGNGNGTVYYGVQVQTNDSHVTIMLHYTTIGSNSTHVARATANTFVED-AWVHVIIAVEDGIIEFYLDGSPIPGGIKSLKGEAIVNDATPIRIGSNPDGEQRFTGLLQDVRLYSSCLNRSQIHELHNQPAKTDLHNVSGYLTYRQEEKEKSFLVEVRDDQEAEGEEVFYLQLVAVQGGARLPMPRPTAILKVMKSDNANGLFSFTGACIPDIAEEGSMISCVVERTRGALDYVYVNYTVTQLDSPADLSNASDFANATGFILFQPGQLSEVLNLLVVNDDLPEVDEHFRVRLVSAKSGDGKPGSTPTSGASIDPEKAVNNVTVKASDHPYGLLQFQTTPVPVG---MIRPALEEARVTVQEEAGVVRLLVARAQGLLGRVMVGYRTSPFTAAGSEDYE---GFLDFLPGERFKYINVTIIDNSVPELDKVFRVELYNPNGGVDPYFASEGSGSGESETDFFLPSFHYHHANLGAAARIIVTIAASDEAHGVFQFGADSLIVNGTEPEEGRSTVVLQVIRTFGALSNVTVYWEADAASEGELVYRSGNVNFEVGQTVRSIYLLISQDDVPELDKTFKVRLTNASHGRLGKETTATLTVLASDDPYGLFVFSDNTRPVRVAEANALVALTIQRRKGLMGRVRVAYRTLRDTDTVLYSTPGVGRASEGNDFIAVVDSVIFSANQSEVNVTLRVLDDNEPERAESVFLELVSVTLIEGLQPRPVALSPRLGPRNVTIAQVIIEASDDAFGVLQLSSSAVSVPEYYTGPIINVTRIGGIFADVSVKFRAVPLTARVGEDYRVASSDVVLLEGESSKPVPILIINDVVPELEETFRIELLNQTTGGALLGDLTQAIITILPSDDPFGLFVFQAAPITIEEPALTAFEVSVPIVRNAGTMGDVAVQWRATVNGRPATGDLRPVSGEVMFSPGETLKTLKVEVLPDDVPEIEEIIKVELVSATSGGNIGLEKVVDTIVPANDNPHGTVYFEQAVYRVQEPLEGIYIANVTIRRSGGNFGMLEVVYSTLEVDIVSNALKEGR-NFLVYYDSRLAGVPSNAIRRPINITTSTNVLNFCAAFCLRERACQAFSFTN-TTTPSCFWVTSGVSQLSPSPQTFTYLKNTTATASLFSSQAVAGSDFITMTAQTTTMLDGSGVANLTVPILTDSLPEMDESFIIKILKVSLVNVTATARNLPTIRQPDTALVTIGMNGDAFGIFLLYSINPNATQEGLYLEVREEPKTTVLLVIERRGGSMGQVTVEWKYVGGSATPNADFNGTGETLIFAEGDVKKTLEFIITDDTEPENNETLQIGLVSTEGGSRILPSSDTVTILILANDNAAGVVGFHTASRSRIVREGESVTLLVERTAPAIGNVAVDWRIEGPLVPTTFADTSGTLFFSEGILNNTIVLKLLEDTTPEDREEYRVILSNIQTTGVTKTGIAALSAQGREAVVSVEASDEPFGLLSIAPSSLQVTTDEKNTTIRIYINREFGASGAVNISYETVRGSLQDLRQTEGALAQPGQDFRYVSNSVIMQDGQTSVSIPITIIDDDIPELQEFFLVNITSAVLITTLPT--APKLNTEGLVAEIIINANDGIRGIIGWQNIDYVVNETIGVLTLVAYRDAGTYGNVSLFFYAQNLEAQLGLDFNATPSMIYFVDGERHKFIEVQILDDAVPEGGETFQLILANPSAGLQLGENTTATVMILANDDGHGIISFNNSEHFLLREPTSVSGLGTSVATLYIIRDPPQGTFGTVTVQFTITDVNGSLYTDDLTPSSGFVVLEDGVRYKTLEIWAVLDAEPEMNETFTVTLSNPTGGARLGVSLQTFITVLENQAPLGLFRISPSINRTLDTMTVEEHMGTVFLTVSRSNGLESAVSVEWETRSGTAFGMRGEQPVLAVYQSIRDSFASVWCSVPSGDAALVLRLIKGLTQNQTVLYKWQGVFVPVEFVSIQNPKSCVGFTVNGSSYVAVSHADNTVSLTTNISLFRVQADLNLTLEQTFSVSG-FSVKHFSTDLKQYLIASS--------EIFVWNRGSFFLHQSLELQDIIAAVPFRRGSSNVQHLAVCRNRTSAACFIYQWTDGRFQNPQPLALNTEVKQVESHQMGGDTFLFIVT---EGLNPACEVFLWGSQQTVFQQTQSILVPGLFSVHPFTTPSGIFHLLLAGVNGSALYSWRSELRQFAEMLKSASAQEFLYLPVPSINSPKSLILASGKSSSLVYELTSVSNQSDFIPSSGELFFQPGVQELEIAVNVIDDDVPEEEEHFRVSLKNPKGGAEIGFRGQVTFFIPANDDTYGIIGFSQNSLMREVEELQSDNPVSLSIERRRGRFGRLTVHWSAYGSLDDIFPTSGVVTFSESQAVATISLNVLADDIPELAEKVTIVLTKVTTIGIIDPSRGASIDYQRAQANLTIRANGSPYGVIGWHLDSQYFITPEPQKSPSNITLSIVRDQGSSGNVLVYYSTKPALHLLPLNQASGGTDYVAKEATVVMMENATVVLVFLTILPDDIPELAETFFVNITRVEVLGGDTGAAQPSVKRPGLEIAEVTIQENDDPRGVLSFNVSKDVSGAVLAFEVPSPGNVLRLAVMRMAGIFGRLVLYWETQSVTASTEDFTPSSGNITFQDGQAMAYIEITIIDDTIVESTETFMVKLIRVIGGARLGVETSVVVSIPANDSPFGRFGFEELKVSVSEPQFLNDPASVATLTVVRSSGGEGVVHLIWLLQEESRDDLSPRNGTLIFNGTESKKTLVIQALADAVLEGEESFTIQLLSPKNEPVIDPVRGVATVVIRPDVGALGTVGIADSSRNVLIGEPICSYNGTALISLIRGPGIFGEIEIFWNITTAAVSEFEETSGKVVMKDRQSAATIQLKALDDEIPEERRVYQLRLSSLTPGSVINPDRQFASITMAASDLPHGLFSFSQASLRATEEDRAVNVTIVRSMGLFGSVWVSFHTEGRTAISGQDFGQSSGRPLFRPGESSRVIPLVIFDDDLPEGPEEFFLNITLVELLNASSMDFTVREYGLQIDQPPAIGNLSSLMVIIQKNDNAEGILEFDPKYVNNTVEEDVGTLSIPVLRRVGSYGQVTVQFVSKGLTAQPDS-DYILLNGSITFQHGQTLSYINVSIVDDTESEFNEIFELQLTGATGGAILGAQLIARITIAKSDSPNGVVRFINQSAITIPNPNSTVRLSLFAERADGLLGDATVMWHIQGPNSNEVLPSMNTDIEP-VNGTFSFRDGEGGVRSIDLKILPHGEVEVTEKFIIMLSVISGEMGVDPRAGSVTLTIEKFGDPNGIVQFTEQDLKERIYSEPSDSEGPLKVSVLVTRREGVMGNITVFWEILSDADTSGDFAALRGSVIILAGQRLAEIILTLLPDSVPELEETYTLRLTSVEGGAELDLNRSSTRLKVRANDEPHGVFVMYSQNQSVVVNAADRSRQLIISVNRLAGAFGNASVGYRISFTTPGQSFTEDTITGNILVKDGEREASIRVPVSSQVFFVTGFNFSVELTDVTLIGPLLGSPPRIQLESKLAVVSVPEVAANPVVGFASLALRVLDIESGQCEALVTRTGLYGNITVRWSSGFPPG-QTPPGYQPGEILPRSGSIMLAHGQRSELISFTALNNISVVTAHAIYLTSVESESPGGARLRTGYTVAEVEPLGLYQFHPNSQHLVIEEDVQTITLYVQRFYGFRSNRSSVSYRTWPGTAQPDKDYVPVTDGQLLFDSRQTSASIRLSILDDTLTEPDEDFYVNLTSVRVLSTTLPLITAQPGIVQKNSISTVTIRAND--------------------------------------------------------------------------------------VVSGFLSIGPAVKLISEDSVEDSPQQKLQLRVRRTAGLSGVVSAKIRAYAGLKTPLVDASQFHREHKGT-----WALEGEDFALETQSVTLLEGQNEVEVTVIMLNDQEPEGQEAFFIYLSDAEGGAQIVSVPDELGFTSFAKIIILGSDLQNGIVGFSLSSLSGQVLDEDSVNRTVTLVLQRQENRAFEDVLVFWRVTFSTTDHALVSHGVDLSKELLQTSGTSIRRKGEVLCALKLEVQPDKNPEYEVWFLVEVYKVGEGAAINQTARFANITMLESDDPRGLVYFAQGSRLPVVTLKATSVSLQIYRDASTASSISVEYRMQELPKVESIGPSLVWPAVAGQDFVMSEGTLTFEIGQSSAGLNIDLTPNIGSSNLTPKRFQVVLSDATGGARVHPEFGLANVTLVSDTETQAVWALLDQLHQPLEETIINRVLHALINKVSRDITPEQLMAVLDASSKILSDAEQTPLKDSSRGLTYDLLCAMANPNRTDTQGVSQLSEVAERFAYSLLTDIKCGAEGKRGITILDNCPYFTIAAHHWYPMQINGHTFIGKNTDTFTLPETLLEVPALPADSTAPSACYKVHFTEYSTEHWFLTNKKPSALNGKVFSVSLYGRGSKPLSEGQEVVYRIHTPDRRGKPKPSQSLCLLWNQAAESWLSDGQFCRLVDDTQNYVECACSHLSIYTAYAEIESLASFNEAFYAAGFICISGFALAMVSHLMCARFLMFAAKLLTHMMVACLGTQICFLVSAFRGRMFSEDSCAALGLFFHYFHLSQFGWMLVQAINFWQILVMNDEHTERRYLLYFLLSWGLPALVIIVLVVVLLGGFGWSIHSVYGLVQGDLCFIPNVYAALCTAALVPLICLVGVLVIFIHAYQVTQQWKAYDDIYRGRTNSSEVPMMLYLFALVTLVCVWAGLHMAYRYIWMLILLVIFNIFLGLYVFSVYFVMHNQLFWPGKATYTVEMNGHSSPDSIYQSTGAATVGGG-EISKSTQNLISAMEEISADWERASLRPSSQPSSIFKPSPQD-EAYITEGGFINTSLVRDEESQEFDDLIFALKTGSGLNVSDNESIHGSHDGGSMANSQIVELRRIPIADTHL", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : * * *. * . .:*:** ***:*.***:* :::*:::**:*:* ****:* * *:*:*** * ****: : :.:*::*** ***:**.**** * * **..* .*.:* *.:.::**********:***. . *:* *.:.*. :.***:******* * *.*:: **.**..***.* *********:.::..: : **::**:**:* :** .. *** :*..*.*::* :.:**:*:.* :* :***: :: :.* **: .:* ****: **: * : * :.:* * **:***.: :** * :**:.*:*.* ** ********:::**::** *****: ** . ***:.****:****:.. :: :: :: :* : :******** **..* :****:* ***:**: *::*.*:*::*** * :.* : :*.*******:** ::* :::*****.** :::*::****:*** : :.* *.* *:*.* * ****: * **: *:::: :.***** .:** :*::*:** : . ::*.. : :. *************** :**::* *:** * **.:****. * **::** ******** ** .:: **:* :.:: : *:********.*:***:*:* *.: ** .* .**.*** *****.:: **:*: .*: **:***: *:***..*:.::**.*:***:::*********:**** *:**:.*:**::***:: *::* *::*:::: * * : :*** *:*** *****::::*::: ** ***** : *:***:. *:** ****: :.* *.*:*** . .* *.***. :: : :.**.** *.: *::.* : ** **** : *.: * **:*: *. *****: *:**: **..****: * :* * * ****:***** **:** .****:** * .: . *:* *.::. ** * .:. *:*..*. :.:*: * :*.:*********:*:*:***:*** .**::******.**:***:. :*. ****** *::**.**:**.*:: *:** * :.*:* :** :*** :.* ** :**::*..:.*::******* *:*:*:** **:**: :::.:*::********:* : *:.*********** :**: ::.:*:*****.****::.**:** :. ***** *::*:. **::* ** * *::*:***.*:*:* **:*::..: : :****:*.*: *:. *:**:::*.:.:*::****::***::***: ***.*:**: *::*::*. .::*: .*:*::* ::**********..:* **********.:.. :***:. :* **** :**** *. *. .:*:*** **:.*** :**** :** *.:***:: .***.: ****:* *:**:* ***::. ..** * : *********.*******:::**** :***********.** * **::*::: . ..*****:* * * * * *****: *:::::**::*:*** **** .**** **** ********* ...:*:*********:**.* * * ** . .::**:** * :**** ********* . :** .:** .. **: * *:* .***:*** :.* ***:***:* *:*** * :*** * :*****:.: :****.. : : **.*::*:*******.*****:*..:**:*.*****:* ***.*:* * *:** **: *: *: :*:*. ***:.** ** * : * *: *****: .* : ..* * ** .****:******:*:*:*.::.**: * **. ::*:* * *****.* ::* *: * :. * .*.:.**::* *:*.. . .:* .**:*. ::: :*** ****:****:**.. :*: :* *.:. ******: *:*:::* *.*****.:***:. * *.* :.******** ** ********:***:** .**** :***********::*.*** :*:*: *****:* ::*:*:***** ** * :*:* * .****:*** ** : : :*** :.:. *.:**:**:**:*:*:*:* * :**: ****** ***:* *:****::** :***.********:::*:*. *:.**.***:::.. ::.***:*:*:* * * ::******: **:*:*****::* * : *.* ::*:*: *::**. :.* **:* *:*. * :*::: : **::**:*:**.***. . : * ***:** :* ..: ** ** * .*****.*******: .:* * : : :*. .*****.:*.*. *****.*:*.:*:* *:*:: : :* *** :*. : * *.:******:*::*.:.**::::** ::*:*:*:* * *:* * ***:*** ***: ***:** . ** *:*: * ****:.** : * **:***::*:: : * ************** : ******.**:*.*:***** * :*** : : . ** *. ***:*:*:: * : .**: :* ***.** **.*:.::**:*. **::* *:*:* :::* **. :*:* *.*** **::*******.*:*.:* ** * * * *:::::*****: **:*::* ** * . .:* * **:* ** : . :::::*:*:.:* **:::**:***.*:****:* . * : * .*:*::*** *:::*:**** :*:* **. **** * :***. *. . *:****.******** ***: ** :::*.****.* ::: **** :***.* ***:*:***.**:** ** * : :****** *::***** *.:*****:: : ***.* *:*:*.** ****:*** :*:**.* :.** **.*::***:*** *:*.* *:**:****:* *. ** *********. :**.**:::******** ** :::. :: :** :*:*.***:**:: :.**:*** * ******* : *::::**: *. * ** .. . : * * .. .:*:*** *:*** :.::.*::* .*.:. * *..::* :.. . .: *:: . :.:.* * **: : .*::*::* ::*:* :* ::* ** ..* **.* ::.:: . * :*.* .**:.: . ::: *:. * * * :.:. .:**: . ..* :* :. * : : ::*:* :: :: **: .. : ::.**..*** *:** . : ****.*.** . *: :*: .:* : :.* *:**.*.** * . :***: :*.:****** ***:*:** :* ***.::** ***:** *:*.**.*:****** ..* . : .**..**::.*:**** :::**:: *. *:*.:** :* .**:*: *.* **:.*:******: *:*.*.:: *:*.:***::***:* * :.**::.* *: *. :**:** .*::: :* ...**:* : *: * : ..** :. : : * :.**:* *:: :: ::* : * ***: . *:. ::: ::* ** . . . ::****::*** * ::* *: *:::. : : ** *:** :* **: *:*******:: *.* :... .: *.* * * *:*::.*:*:** * : :**:: . :*. *** *. * : * * *. * * :** **: .* *** :.*: * **.*** :. * * *. ****** ****: .* :. . :** * ..******.**:*.*:* * ::*:::.:*** **** *: *:*:*::::: * * :: :. * *:* .* *.* :* *:::* : **** ***:::**** ..*.*** *.* ****: **: : *.* ..: .** ****::.* * *::. : ::.*:* ****: *:::*: :: * :: * *::.*** *:* *:**: .*:.: : **:*: ** * ** . : :.* . ** :* ** ::*. :*.. * : : : *:**: ******* * ** *:* . . ***::* ******** **.:* : :** :***.***:*****:. ***..* : :**:* *:** *:.:* *:. :* *. .*:* ..::******.**:**:**:**. ** :: :*: * ******:** :*:::* ******* *::**:*** *::.**.**: * *. **:.****: * *. **.::* * . : *: *.* . * :******:* * : ** * *. *.*:: * : * :*.** *****::******:::*: : *.:: :*** :**: ::.:* * :*. *:* *.**: *: * : ** : * . * *: *.: : ****.***:** *.::*.********** :. : :.* ***:***:*.:**:.**:::. *.: *.:.****.** .:* :* :... :. ::::.** **:..***: * **::.* . *:. : . * * *:: *.:.*.* ***. *** * *:::::* :* ... ::* * ** ::* *::*:.** : * *:: * **: : **:. : : : :: . . *..::*:.:.*.:.***:**:.: .**:**:*::*: ..*::: :.**. * : ***::**:.: .***.* .*:*:* :*: .: .*:::*: *.. .:.::*::* *.* :* :*:*****. . :. * : . *:: :** ** : * :*:**.: :.*: :.: . . :: ::* .*::* *: .::::. : .: * **:* *** : :: :* *:.* .::* :*:*::.**** *:::*::.:***:** * **::** ::* ****:***:*** .* * * *.: * : ** *****:* :*****:. * * ..* :* .** .:*.: *:. * : :*::*.* : *: *:**:*.. *****::**** *.: :*. .:.** *: ****.*. *:* :***: **:.*. :**:: *** ..*::* :: **::*:*** :****.** ** *: *:: ***: ** * *****:** *..****:. :* **:**:**.::**:*.* * **:*:.: ::***** : :*: : * *** *:: .** :.. .:. ** * *::** : **:*.**:*.*:: **:*.**:****::.**: *::. ****.***::* * ** * ***** * **: * : :** :*:. . .:* *:*.***:::**::..: .:*..**:*:.: *:.:: *.:.:**:***::.: * * * ******** *****.*:*::*::: :********:* *:.**. :. *:****:::*:*****:.**::**::***. ***********.*.**:*: **.**: . ::*:**:*:. . **::*.**.***:*::*** :**:.******* **: *******::*:*:*:::* * : *: .:***::********:**** ******* *** *:*:******:. ***.***::*****::*:*::******:::. :*.****** ::***:*:**** : ***** ***::*** * **:********..*.: : :.*:. .* *:.*******.****:..**** *:: **.*. :*.***: :: :.**: **: *****************:**.****** :**::**::::****************", "identical_positions": 2859, "similar_positions": 1974, "identity": "45.16%" }, { "cls_id": "homologset.agr.HGNC:17418", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9I7L4-1", "uniprot_id": "Q9I7L4_DROME", "id": "Q9I7L4-1", "name": "", "aln": "----------------------------------------------------------------------------MASTSRAARSQNAIPSQEAQQP-------VDVVDAKVRAILNYILDHTAQKIPIKDKDLIAVAG--DKSELKKRLPLVTNLLAETFGIILTPLDATTKTFICTAEEPVASIHELTPAQ-RPQFTLLYIILMYIFLRGNRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQYLKRERSQLSAYDDSKTFFLWGPRAKAEFTFEQMVQFASKLLNQHPKVFGHHLSMAQEGVNAE---------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A8MXT2-1", "uniprot_id": "MAGBH_HUMAN", "id": "A8MXT2-1", "name": "Melanoma-associated antigen B17", "aln": "MPRGQASKRRAREKRRQARGEDQCLGGAQATAAEKEKLPSSSSPACQSPPQSFPNAGIPQESQRASYPSSPASAVSLTSSDEGAKGQKGESPNSFHGPSSSESTGRDLLNTKTGELVQFLLNKYIRKEPITREAMLKVINRKYKQHFPEILRRSTENVEVVFGLYLKEMDPSRQSYVLVGKLDFPNQGSLSDGGGFPLSGLLMVLLSTIFMHGNRATEEEMWECLNALGMYKGRKHFIYG-EPQELVTKDLVREGYLEYQ--QVPSSDPPRYEFLWGPRARAETSKMKVLEFVAKLNDTVASTYKSRYEEALREEEEQARARAVARDSARARASRSFQP", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ::*:...*:.*:. ..:. : * *::::*. :::::*:: :* **. : :: * . *..: : * *: : .**: *. :*.: :::: ..: ... .*: . * ** ::* **::*** :.::: *: *.:* ..:* :* : :: : : :*:: **: : *:.: * .: *******:** : ::::*.:** : ...: : . * . : : ", "identical_positions": 51, "similar_positions": 107, "identity": "15.04%" }, { "cls_id": "homologset.agr.HGNC:17419", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q3T1J1-1", "uniprot_id": "IF5A1_RAT", "id": "Q3T1J1-1", "name": "Eukaryotic translation initiation factor 5A-1", "aln": "MAD-DLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDG-YLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P63242-1", "uniprot_id": "IF5A1_MOUSE", "id": "P63242-1", "name": "Eukaryotic translation initiation factor 5A-1", "aln": "MAD-DLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDG-YLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6IS14-1", "uniprot_id": "IF5AL_HUMAN", "id": "Q6IS14-1", "name": "Eukaryotic translation initiation factor 5A-1-like", "aln": "MAD-DLDFETGDAGASATFPMQCSALRKNGFVVLKGWPCKIVEMSASKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDG-YLSLLQDSGEVPEDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NX89-1", "uniprot_id": "IF5A1_DANRE", "id": "Q6NX89-1", "name": "Eukaryotic translation initiation factor 5A-1", "aln": "MADPDLDFASGDAGASATYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTNKKYEDICPSTHNMDVPNIKRNDYQLVDISEG-FLSLMMDNGDVREDLRVPDGDLGKEIENKFAAGEEMLVTVLSAMGEESAVALKPMTK---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9GU68-1", "uniprot_id": "IF5A_DROME", "id": "Q9GU68-1", "name": "Eukaryotic translation initiation factor 5A", "aln": "MAELDDQFETTDSGASTTYPMQCSALRKNGFVMLKSRPCKIVEMSTSKTGKHGHAKVHMVGIDIFSNKKYEDICPSTHNMDVPNVKREDLQLIAISDDSFLTLMTESGDLREDLKVPEGELGEQLRLDFDSGKDLLCTVLKACGEECVIAIKTNTALDK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P23301-1", "uniprot_id": "IF5A1_YEAST", "id": "P23301-1", "name": "Eukaryotic translation initiation factor 5A-1", "aln": "MSDEEHTFETADAGSSATYPMQCSALRKNGFVVIKSRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMEVPVVKRNEYQLLDIDDG-FLSLMNMDGDTKDDVKAPEGELGDSLQTAFDEGKDLMVTIISAMGEEAAISFKEAARTD-", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P19211-1", "uniprot_id": "IF5A2_YEAST", "id": "P19211-1", "name": "Eukaryotic translation initiation factor 5A-2", "aln": "MSDEEHTFENADAGASATYPMQCSALRKNGFVVIKGRPCKIVDMSTSKTGKHGHAKVHLVTLDIFTGKKLEDLSPSTHNLEVPFVKRSEYQLLDIDDG-YLSLMTMDGETKDDVKAPEGELGDSMQAAFDEGKDLMVTIISAMGEEAAISFKEAPRSD-", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*:: : * . *:*:*:*:*************::*. *****:**:************:* :***:.** **:.*****::** :**.: **: *.:. :*:*: .*: :*:: *:*:**..:. : *:::: *::.* **..:::* . ", "identical_positions": 73, "similar_positions": 56, "identity": "45.91%" }, { "cls_id": "homologset.agr.HGNC:1742", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A0G2JYR4-1", "uniprot_id": "A0A0G2JYR4_RAT", "id": "A0A0G2JYR4-1", "name": "Lipopolysaccharide-responsive and beige-like anchor protein", "aln": "MASEDNRAPSRPPTGDDGGGEGKEETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEAESITCMVELLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDSMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGQWPPHAGKLLSVLKHMPQKYAPDAFFNFPGKSAAAIALPPIARWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIITSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSDALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLLYDGKLSSAIAFTYNARATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSVGGVQVLFPLFAQLDYRQYLSDEV--DLTICTTLLAFIMELLKNSVAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNG------------MPLLKQLCDHVLLNPAVWIHTPAKVQLMLYTYLSTEFIGTVNIYNTVRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEILSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMAEHPNSMTPAFDQRNGLRVIYKLLASKSEGIRVQALKALGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTMYNVLFEILIEQICTQVIHKQHPDPDSTVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKSSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREEQGKGDEEIGPCSASLSPEGTGVT----------------------------------------------------RDVDVSEGPQHSDRKESLISPHFTTNS-----------------------------------------------------------------------------------------------DENSSIGKASSIDSASNIELQTPGY---EKKVEQ---GNQELLDQ-----------------------------AAMEEATTNEAKHACDLEASS--DAVEPVTLTSTSSEP-GKDTVTISGVRASVSSPSEQDAAEMPELLEN-------------------------------SGVEEEDGDDDYVELKVEGIE---GSPAEEARLPAERQAEEARLPAEHQAEEACQPAERQGESVSVAASEGREEVE----------VCGNG--CELQEEAPITKSHNDPETGDSK------------ESGFPTVATAGSLATSS-------------EVPVPQTTLQ---PDSDEMLGGGVK-TDIAGETESVSDCADDVSEAP----------ATSEQK--------------IAKLDVSSVASDTER----------------------------FELKASTSTEAPQPQRHGLEISRQQEHPRQETAPDTGDQQRRDSRPT-----------MFRIPEFKWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENVEPAQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKNMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKARGEA--AKSLKAVHSLVPVGRSA-AKSPVDIVTGGISPVRDLDRL-LQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEP----QDERHSQSLKEAGSDNGTVSLPD---------------AENTTAEFSSLTLSSVEESLEGTSSTRRRDSGLGEETASGLGSSMSVASPAAPLGVSTGPDAISEVLCTLSLEVNKSQETKNDGGNELDGKVTPS---VPVSKNVNVKDILRSLVNMPADG-VTVDPALLPPACLG----ALGDLSVDPPVQFRSFDRSVIIATKKS--------------SVLPSTLTASAPSNAVSVVSSVDSTQVPDAGGESPGS---------RSPNAKLP-SVPAVGSVP--QDPVTHMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREEEKMCDHLIRAAKYRDHVTATQLIQKVINLLRDKHGAWGSCAVS----------RPREFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEH-----------AADEDILAKGKQSIKSQALGNQNSENEALLEGDDDTLSSVDEKDLEN-LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDSATVKKVVNYLPRVGVGTSFGLPQTRRISLATPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFAERFESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVRINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVSLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQAYLLLQSPLMFTDQAQQDVIMVLKFPSNSPVTHVAANTQPGLAVPAVITVTANRLFAVNKWHS------LPAHQG-AVQDQPYQLPVEIDPLIACG------TGTHRRQVTDLLDQSIQVHSQCFVITSDNRHILVCGFWDKSFRVYSTDTGKLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKSSGIGDNPGSETTTPRAILTGHDYEITCAVVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGCFCTFSVNGKLQATVETDDHIRAIQLSRDGQYLLTGGDNGVVIVRQVSDLKQLFAYPGCDAGIRAMALSFDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ESE1-1", "uniprot_id": "LRBA_MOUSE", "id": "Q9ESE1-1", "name": "Lipopolysaccharide-responsive and beige-like anchor protein", "aln": "MASEDNRAPSRPPTGDDGGGGGKEETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESIMCMVELLEKCDVTCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDSMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGQWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIARWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIITSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSDALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLLYDGKLSSAIAFMYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYKQYLSDEV--DLTICTTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNG------------MPLLKQLCDHILLNPAVWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEILSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMAEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKALGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTMYNVLFEILIEQICTQVIHKQHPDPDSTVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREEQRKGDEETGPCSSSLVPEGTGAT----------------------------------------------------RGVDVSVGSQHEDRKDSPISPHFTRNS-----------------------------------------------------------------------------------------------DENSSIGRASSIDSASNTELQTHDMSSDEKKVER---ENQELLDQ-----------------------------ATVEETATNGAKD--DLETSS--DAAEPVTINSNSLEP-GKDTVTISEVSASISSPSEEDAAEMPELLEK-------------------------------SGVEEKE-DDDYVELKVE------GSPTEEAGLPTELQ----------------------GEGLSVAASGGREEPD----------MCGHG--CEVQVEAPITKIHNDPETTDSE------------DSRFPTVATAGSLATSS-------------EVPVPQATVQ---SDSHEMLDGGMKATNLAGETESVSDCADNVSEAP----------ATSEQK--------------ITKLDVSSVASDTER----------------------------FELKASTSTEAPQPQRHGLEISRQQEQTAQGTAPDAVDQQRRDSRST-----------MFRIPEFKWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKNMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKARGDT--AKSSKTIHSLIPMGKSA-AKSPVDIVTGGISSVRDLDRLPARTWTLIGLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEP----QDERHSQSLKETSSDNGNASLPD---------------AENTPAEFSSLTLSSVEESLEGTSCTRRRDSGLGEETASGLGSGLSVASPAAPLGVSAGPDAISEVLCTLSLEVNKSQETRIDGGNELDRKVTPS---VPVSKNVNVKDILRSLVNMPADG-VTVDPALLPPACLG----ALGDLSVDPPMQFRSFDRSVIIATKKS--------------SVLPSALTTSAPSSAVSVVSSVDPTHASDTGGESPGS---------RSPKCKTALSCKQLAPSH--KTPAAHMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREEEKMCDHLIRAAKYRDHVTATQLIQKIINLLTDKHGAWGSSAVS----------RPREFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEH-----------AADEDILAKGKQSIKSQALGNQNSENEALLEGDDDTLSSVDEKDLEN-LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLATPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFAERFESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVRINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQA-----SPLMFTDQAQQDVIMVLKFPSNSPVTHVAANTQPGLAMPAVITVTANRLFAVNKWHN------LPAHQG-AVQDQPYQLPVEIDPLIACG------TGTHRRQVTDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGKLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKSSGIGDNPGGETATPRAILTGHDYEITCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGCFCTFSVNGKLQATVETDDHIRAIQLSRDGQYLLTGGDNGVVIVRQVSDLKQLFAYPGCDAGIRAMALSFDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P50851-1", "uniprot_id": "LRBA_HUMAN", "id": "P50851-1", "name": "Lipopolysaccharide-responsive and beige-like anchor protein", "aln": "MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEI--DLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNG------------MPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIR----------------------------------------------------RDINVSVGSQQPDTKDSPVCPHFTTNG-----------------------------------------------------------------------------------------------NENSSIEKTSSLESASNIELQTTNTSYEEMKAEQ---ENQELPDE-----------------------------GTLEETLTNETRNADDLEVSS--DIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDK-------------------------------SIVEEEE-DDDYVELKVE------GSPTEEANLPTELQ----------------------DNSLSPAASEAGEKLD----------MFGNDDKLIFQEGKPVTEKQTDTETQDSK------------DSGIQTMTASGSSAMSP-------------ETTVSQIAVE---SDLGQMLEEGKKATNLTRETKLINDCHGSVSEA------------SSEQK--------------IAKLDVSNVATDTER----------------------------LELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRST-----------VFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGD----KALKPMHSLIPLGKSA-AKSPVDIVTGGISPVRDLDRL-LQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEP----QNERHSQSCTETGSENENVSLS-----------------EITPAAFSTLTTASVEES-ESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPS---VSVSKNVNVKDILRSLVNIPADG-VTVDPALLPPACLG----ALGDLSVEQPVQFRSFDRSVIVAAKKS--------------AVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGS---------RSSNAKLP-SVPTVDSVS--QDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVS----------RPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLEN-LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQV-----SPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHN------LPAHQG-AVQDQPYQLPVEIDPLIASN------TGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AI36-1", "uniprot_id": "A0A8M3AI36_DANRE", "id": "A0A8M3AI36-1", "name": "Neurobeachin", "aln": "MASAGDSAVQ----------------------------IPIRGIRMKFAVLAGLLEAGEVSNRDTVETIFNLLVGGQFDLEMNFIIQETESIICMVELLDKCDSTCQAEVWNMFTAVLKKSLRNLQACTDIGLIQLVLQRIDRAETMIADLMVDMLGVLASYSITVKELKLYFSKLKGEQGQWPPHAVKLLSVLKSMAQRNGPDSFFSFPGKSAAAIALPPIAKWPYQNGFTFHTWLRLDPINNINVDKDKPYLYCFRTNKGLGYSAHFVGGCLIVTSLKSKAKGFQHCVKYDFKPQKWYMVTIVHIYNRWKNSEISCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMGAVYLFSEALSAAQILAIYQLGPGYKGTFKHKAESDLLFAEHHK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLYDGKLSACIAFTYNPRATDAQLCLESSPKDNASIFVHSPHALMLQDVKAVVTHSVQSAIHSIGGVQVLFPLFAQLDFLQHSGDEL--DTSVCCTLLSFVMELLKGSVAMQEQVLACKGFLVIGYSLEKSSKVHVTRPVLDIVLAFARYLSNLPTG------------VMLLKQLCDHILFNPTIWIHAPAKVQLVLYTYLATEFISTVTIYNAIRRVGTVLQVMHTLKYFYWVVNPLDRSGITPKGLDGPRPNQKEIHSLRAFLLLFVKQLIMKDHGIKEDELQSILNYLLTMHEDDNLMDVLQLLVALMSEHPGSMVQAFDQRNGIRVIFKLLASTSEGIRVQALKVLGYFLKYLSPKRKSEVMLAHGLFSLLTERLMLHSNQFTVTTYNVLFEILTEQICTQVIHKQHPDPDSTVKIQNPQILKVIAALLKNAPPEAESMEVRRIFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCFINPKNSEEQKITEMVYAIFRILLYHAIKYEWGGWRVWVDTLSITHSKVTFEQHKENLARMFLEYQRIGSEGGSESRIRTISGVSQDS----------------------------------------------------QFLASANGELHTEEKAPSTVIELRVEE-----------------------------------------------------------------------------------------------QDNDQTADNEEMQTQIPVTVSNILVRDEEERLTDTVPTSVEMQDRDK-----------------------DEQYAVKEPEKDNEIKHMDDNHKTGDEDREQMENVKTEGRVEEESSNLSIKDDTDSPQTETDKNAKDATEAVKM-------------------------------SDEGKTSNAENEQNVQVEDEKKDLGDSTLEAVKEDSTQKSSEVLVHEETSTTGASVVNEDSTDVSSASNFVKVSDDSTEDSSFVSATTGETDDHGVEREDGGKEKENKSETDKDEKLMENEKTVGIQDSPAPMVEVDLNQSSSP-------------EETKPQTEGHG-DVEAEQTTTEQKSKAEVSSSAESISQDAANNQDSPKVAGTDNSANKTKEIK--------------IARLDVSSVASDTER----------------------------LELKDTSATNP------------SANQAAPTSPTGQSNEGSSSARST-----------MFRIPEFKWSHMHQRLLTDLLFSIETDVQMWRSHSTKTVMDFVNSSENVVFVHNTVHLISQVVDNLIMACGGILPLLSAATSSSHELENIEPSQGLAVEASLMFLQRLINLVDVLIFASSLNFTEIEAEKNMSSGGILRQCLRLVCAMAVRNCLECQQHTLSKSGAE-----SSRGQQSLLGAAKSIPAQSPVDIVTGGMSPIRDLDRL-LQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEP----HNDRR-----------------------------------NTQRSQSVRSTESVQSDLENGLSPLHRDSGIEDEKASDIQSNVKAQT---------GPDAVSEALSTLSDEVRRGQEDRDSKG-----------------KNVNVKDILRSLVSAPSDD-IMVDPSLIPPGFLG----AVSEASRDQSIQFHSFDRSVVVAPKKAGGAPSPGMSTVSASASVPSATAASSGGTPVNSVSVVSAGETVQSTESTPGG---------TSTSSNLP-SVPALSPMT--QTSTPNMSISERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSHTMKDHLVRVANEAEFILSRQRAEDIQKHAEFESHCAQYSAEKRDEEKMCDHLIRAAKYRDHVTSTQLIQKIVNILTDKHGAWGSSAFS----------RPREFWRLDYWEDDLRRRRRFIRNPFGSTHSEATLKAAAEH-----------APEEDVLK-GKQSIRSSVLGNQNSESELLLE-DDDTLSSLEEKELEN-LTGPVNLSTSAQLVAPAVVVKGTLSITALELYFEVDEEDPSFKNIDPKILAYTEGLHGKWLFTEIRAVFSRRYLLQNTALEVFMANRTAVMFNFPDAATVKKVVHCLPRVGVGTNVGLPQTRRISLASPKQLYKASNMTQRWQRREISNFEYLMFLNTISGRTFNDLNQYPVFPWVITNYDSEELDLTLPSNYRDLSKPIGALNPKRAAFFSERFESWEDEQVPKFHYGTHYSTSSFTQMWLLRIEPFTTFFLNFQGGKFDHADRTFSSVSRAWRNCQRDTSDVKELIPEFYYLPEMFVNSNNYNLGVMDDGTVVSDVELPPWAKSPEEFVRINRLALESEFVSCQLHQWIDLIFGYKQQGPEAIRALNVFYYLTYEGAVNLSSISDPMLREAVESQIRSFGQTPCQLLIEPHPPRSSAMQVYLLLQTPLMFTEQMQQDVIMVLKFPSNSPVTHVAANTQSGLTNAAVITVTANRLFAVNKWHG------LTGHQTSSVQDQQYQLPVEIDPLIASN------VGAHRRQISDLLDQSIQVNAQCFVITADNRFILLCGFWDKSFRVYSTDTGKLTQIVFGHLDVVTCLARSESYIGGDCYVLSGSRDATLLLWYWNGKHSSIGESAGTEFVTPRAILTGHDCEVTCASVCAELGLVISGCREGPCLVHSMNGDLLRTLEGPDGCMRPRLVLSSTEGHCVIYYDKGHFCVFSINGKLLGHMEVEDNIKAMLLSKDGQYLLCGGDAGVLNVWQIHDLKQLFTYPGCDAGIRSMAIAHDQRCIITGMASGSIVLFYNDFNRWHHEYQTRY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W4E2-5", "uniprot_id": "NBEA_DROME", "id": "Q9W4E2-5", "name": "Neurobeachin", "aln": "MADIMRPPYSEIKRPDE-------------------IVRMTTADNLKFAVLIGLIEVGQVTNREVVNTVLHLLVGGEFDMELNFVIQDAQNIKHMLELLDHCPPNLQAEIWSVFIAILRKSVRNLQACTDVGLIEHVLVRLQRSETVVADLLIEMLGVLASYSITVKELKLLFGTMKATNGKWPRHSAKLLNVLRQMPHRNGPDVFFSFPGRKGSAMVLPPLAKWPYENGFTFTTWFRLDPINSVNIEREKPYLYCFKTSKGVGYTAHFVGNCLVLTSMKVKGKGFQHCVKYEFQPRKWYMIAIVYIYNRWTKSEIKCLVNGQLASSTEMAWFVSTNDPFDKCYIGATPELDEERVFCGQMSAIYLFSEALTTQQICAMHRLGPGYKSQFRFDNECYLNLPDNHKRVSHFQLLPATLGASALSGGSGSGTGSGTGNDASAAAAAAVAAGQQQQLQLQFQILAAEQEARAIDWSDEKLDLNAAFVKIRAVLTARNAVTLAGSSSTGTTAVATAAAAAAAAGAGAGTTAAATSAAAAAAATQNENDAAVGQQQHATHHHATAATGSADDPLGHLPTGNASSSSSSFEQLRRMSSVSSLNSMVGSADTEEVNQLKAVLYDGKLSNAIVFMYNPVATDGQLCLQSSPKGNVSYFVHTPHALMLQDVKAVVTHSIHCTLNSIGGIQVLFPLFSQLDMAHEGLGDIKRDPTLCSKLLGFICELVETSQTVQQHMIQNRGFLVISFMLQRSSREHLTLEVLGSFLNLTKYLVTCLSANSDLLLKQLFCFSFLTWQLLDHVLFNPALWIYTPANVQARLYSYLATEFLSDTQIYSNVRRVSTVLQTVHTLKYYYWVVNPRAKSGIIPKGLDGPRPAQKDILAIRAYILLFLKQLIMIGNGVKEDELQSILNYLTTMHEDENLHDVLQMLISLMSEHPSSMVPAFDVKHGVRSIFKLLAAESQLIRLQALKLLGFFLSRSTHKRKYDVMSPHNLYTLLAERLLLYEESLSLPTYNVLYEIMTEHISQQILYTRHPEPESHYRLENPMILKVVATLIRQSKQTESLIDVKKLFLQDMTLLCNSNRENRRTVLQMSVWQEWLIAMAYIHPKSSEEQKISDMVYSLFRMLLHHAIKHEYGGWRVWVDTLAIVHSKVSYEEFKLQFAQMYEHYERQRTDNITDPALRQARPISTISGWEREELHQQQNGGSAAAVATNQTAAVKGSVSIASLEDVPPVVEEEVEELELEEVEIQEGPITEETEQKSVIANISDVYNEQLKTDATCNGNLEDVKEEEPVQQQIGDLEKQPEPSTPLGALRETLQLGDDMDVEELELATAKDALNAEQHVSRVLQASEAALNDCKMAVDDVLQESSSVLKDEEIELAVNEVVQGVLNNEKKTQSQDNKDNKEQPGEQDVNVSLLNSKNLLNNNNNNNNNSPSPTPTTATATAETEAETEVNANEIVSSTEAPKAETETSVAPEVETPETAKPSPIVPSPVLATNQKTEDAANKLNNNEKLAEISASPEPPIVVETPEADLLQLSDSETKPNKETEAEDSVALAVRDIVEQLIDKVIDATEAESASETKTETNNNEIPKKEKQ-TSEEPEDVETAETLAAAAKEIVQEVVEAALVMVQEESTQEKPEKGANSEEEKNEIGKEEILLQLEEKPASTEVQETKIEGDLKKPEDPKGHSSVEPKTPNLEEPKPQETEQQKSQEVAEELPQKPEEQVVAIVNQVLDTLVDDTVKAVAAEQTTQTSPAPEEQSPQILAMESPATSVRVKPTEVDSTTQTTPKNEAGSSLLVEQVQQVLQEDDAQQSAGMTIEDEDYSNQQAAAAVENANSSQLDANHYGPGNPESKQQQQRSKSGSTRPMFSPGPTRPPFRIPEFKWSYIHQRLLSDVLFSLETDIQVWRSHSTKSVLDFVNSSENAIFVVNTVHLISQLADNLIIACGGLLPLLASATSPNSELDVLEPTQGMPLEVAVSFLQRLVNMADVLIFATSLNFGELEAEKNMSSGGILRQCLRLVCTCAVRNCLECKERTRYNVGALARDVPGAAHLQALIRGAQAS-PKNIVESITGQLSPVKDPEKL-LQDMDVNRLRAVIYRDVEETKQAQFLSLAIVYFISVLMVSKYRDILEPPAEPQIQRQSPVLQRTAGGGGRQIQDSDYEIIVVDENNPSVLADNDSHSSGPPSIKANQTTTIATTTTTTATTHINNNNTKTTTSNAPTATIKIQQQPLSPPKPLVPQKLPKSVDSDVGSLNMNSTENEVPEVESSSEILIDDHKPSHSNDESWTDVNLNEDAAVQAASAGIVVGLVDNRGNVISDKHDPSHHNQQQQQQAGIIGQQQQ-------------HGSLGHSERGDKPDSEISVVRVPDGYGGAGSGGGVNSGQGQGVPSNQRPRPEELPMKAPALVAQLPLTTPSREASLTQKLEIALGPVCPLLREIMVDFAPFLSKTLVGSHGQELLMEGKGLTTFKNSHSVVELVMLLCSQEWQNSLQKHAGLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRMRADDVLKHADFESQCAQTLLERREEERMCDHLITAARRRDNVIASRLLEKVRNIMCNRHGAWGDSSSTSSGGAIVGAVQKSPYWKLDAWEDDARRRKRMVQNPRGSSHPQATLKAALEN----------GGPEDAILQTRDEFHTQIAVSRTHPSGQHNGELLDDAELLIEDRELDLDLTGPVNISTKARLIAPGLVAPGTVSITSTEMFFEVDEEHPEFQKIDGEVLKYCDHLHGKWYFSEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESWDSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYRLGHREDGALVDDIELPPWAKSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHL-----SPMMFS-AMPEDLCQMLKFYQNSPVIHISANTYPQLSLPSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSNQPLTIDPVLAVHGTNNNSNAASRRHLGDNFSQMLKIRSNCFVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCTVLLWHWNARTQSIVGE--GDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTFGDLLRSLDPPAEFHSPELITMSREGFIVINYDKGNVAAYTINGKKLRHETHNDNLQCMLLSRDGEYLMTAGDRGIVEVWRTFNLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHIDFNRWHHEYQQRY", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**. . . .:***** **:*.*:*:**: *:*:::*****:**:*:**:**: :.* *::**::* . ***:*.:* *:*:**:****.**::**:: ** :::: :.::***:::********.:**:**** *..::. :*:** *: ***.**: *.:: .** **.***:..:*:.***:*:***:***** **:*:**:*.:*::::*******:*.**:**:*****.**::**:* *.********::*:*:****::**:*****.:**: * ***:*** *::***.*.*.****::*:: * :******* *:****:**.: ** *:::** ***. *:.. *. * :.::** :******* .*.* **. ***.****:****.* * ***:************:***::.:::*:**:*******:*** : .:: * ::* .**.*: **:: * ::*:::: :*****.: *::**: *:: ** * :::** . .. * ** **:*:**::**::**:** **:**:***:. . **. :***.*** :*****:**.*** :*** ********* **:: ::**::*:*:***:* . *:******:***** *****:** ****:*::**:***.** *** ::*:* *:****: *: **:**** :*:**. : *** :** *.*::**:***:* : :::. ****:**: *:* *:::.:**:*:* :::** ****:*:*:::: . ::*:: **.** * *..*****::** ******::::.:::**.*:****::***::**:**:**:*:*:**********:*.****::* .* ::*.:: . : : : . : * : : .: ::... ..:: :. : : . : :. . : . . . : : .: . .. . . * :::.: : .: :. : : :: : *. . . :* . . .:. * . : . : .. . . * ..: : : . . .. * . .* . : : . :: : :. . .: ..* . : :*...: * : :* : . :. . :: . . : .: .* ******:** :*****:*:***:***:*:*******:*:******:*.:** **:*****: **:::****:****::***.. **: :**:**:.:*.:: *****:.:.******:**.* *:****.***************: ********:::: : . . ::*: .:: .:. *: :** :*.::* ::* : : ****::**:*::******:**:****************** : :*: . : : : . : : ::.:. * . . *..: . * : . . * : :* : *. * : . .: : . :. .:.: : :. ::: ::. :: . : . . :. * . .. . : . . : . . . *::::** ** ..******:********:**:********:**..*. :*.* *****************:**:********:*******::****:***********.* **:*: :**:*** *** ::*::*:****** **: **:* :::*::*: *:: ::*****..: : : :*:** **** ***:*:::** **:*.:****:* *: ..:: :* .: . .:.. :...: * **: :::::*: *:***.:** *:*:**.:*. **:*:*: *::******.*.*::** ::* * : ***** *:*:*::*********.***:*:*.*.:::* *** *****:: ******* . *:***** *: :*:** : *****:**:***************:**::*******:****:***:*::***:**:*:************.* *:* **:***:.: :* *********::*. **:*:***** ** :******:.** ***:* :*:*.******:******:*:***** * ..*.** :**::*.*:*******:.****:***:***********************:****:** **********:*.*..: **::***** ***.*****.***:******.***: :*:**: :*: :*** .**** *::*** . *: .:*:****.: ****:*: . : *. : *: ***::* . **:: * :.* :::.::*** * *.*.:: *****:****::*:*.:: *:**** .****:****. * .:**: *** *.*:***:**.: ..* . : :*** ****: :*.. :.******:**. :** *:*: *****:*: * *.*: * **. ** *::* ...:::*** :*:::.: **:**:**: .** *:: * : :* *:::*.*:****::*::.**: :::*:::***::*: ********** **", "identical_positions": 1234, "similar_positions": 863, "identity": "35.07%" }, { "cls_id": "homologset.agr.HGNC:17422", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P69478-1", "uniprot_id": "CHSTB_RAT", "id": "P69478-1", "name": "Carbohydrate sulfotransferase 11", "aln": "MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAILHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLSGRGK-YSDPMEIPANEAHVSANLKTLNQYSIPEINHRLK-SYMKFLFVREPFERLVSAYRNKFTQKYNTS--FHKRYGTKIIRRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEP--FNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLRLAGVSGYLKFPTYAKSTRTTDEMTTEFFQNISAEHQTQLYEVYKLDFLMFNYSVPNYLKLD--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JME2-1", "uniprot_id": "CHSTB_MOUSE", "id": "Q9JME2-1", "name": "Carbohydrate sulfotransferase 11", "aln": "MKPALLEVMRMNRICRMVLATCFGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAILHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLSGRGK-YSDPMEIPANEAHVSANLKTLNQYSIPEINHRLK-SYMKFLFVREPFERLVSAYRNKFTQKYNTS--FHKRYGTKIIRRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEP--FNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVSGYLKFPTYAKSTRTTDEMTTEFFQNISAEHQTQLYEVYKLDFLMFNYSVPNYLKLD--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NPF2-1", "uniprot_id": "CHSTB_HUMAN", "id": "Q9NPF2-1", "name": "Carbohydrate sulfotransferase 11", "aln": "MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGK-YSDPMEIPANEAHVSANLKTLNQYSIPEINHRLK-SYMKFLFVREPFERLVSAYRNKFTQKYNIS--FHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEP--FNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q7T3S3-1", "uniprot_id": "CHSTB_DANRE", "id": "Q7T3S3-1", "name": "Carbohydrate sulfotransferase 11", "aln": "MKQTILDLMRMSRICRMVLATCLGSFILVIFYFQSMFQPVMRRNPFAAEGCCRKGSRNALQELYNPTQAEFSAAAVLHQARRDQVAETCRAHSASSRKRRVLTPSDLKHLVVDEDHELIYCYVPKVACTNWKRVMMVLSGRGK-YSNPMEIPSNEAHVPSNLKTLNQYSIPDINHRLK-NYLKFLFVREPFERLVSAYRNKFTLRYNTS--FHKRYGTKIVRRYRKNATTEALQSGADVKFQEFAEYLVDPGTQREAP--LNEHWQTVYSLCHPCHIHYDLVGKYETLEDDANYVLKLVGEGDSLRFPSFAKSTRTTDQMAAMFFGNISSQQQSQLYQLYKLDYLMFNYSIPSYLKLQ--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VJG5-1", "uniprot_id": "Q9VJG5_DROME", "id": "Q9VJG5-1", "name": "Carbohydrate sulfotransferase", "aln": "----------MDQLVWLSFCISIGFSLLGNFSTGLPFEDGNNNN-------------------VKITRRSLELTQTINIQRQEFMQRQCELLGDHTQTLEDLSELQMDHMIVDKEHKLLYCYVPKVACTNWKRVLMMLTNKWHNGTDPLQIPGSLAHSVGMFTKLYDLSEAEQQQVLSDEYTRFILVRHPLERLLSAYRNKLEGDSPSARYFQSRVGRQIVKELRPGASNNSLERGDDVSFGEFIQYLVTPELSRANQSDYNEHWEVIAKLCNPCVMKYNVVGKYDTLLDDSALALYLAG-ADNLTFPTGHKPSSTRANLR-NYFDPLPIGAIRKLYDIYEDDFRLFDYALDEVLGFEFG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.:: : :. .:* :* * :. ..* : : .:. : :: *:: : *. . ::. . *: ::.*::**::*:*:**************::*:*:.: : ::*::**.. ** . :..* : * .: :: *. .* :*::**.*:***:******: : *:.* * :*::. * .*: ::*. * **.* ** **: * .* ****:.: .**:** ::*::****:** :*: .* *.* .. * **: *.: * :: :* :. :**::*: *: :*:*:: . * :: ", "identical_positions": 100, "similar_positions": 122, "identity": "27.78%" }, { "cls_id": "homologset.agr.HGNC:17423", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8M1Q1N4-1", "uniprot_id": "A0A8M1Q1N4_DANRE", "id": "A0A8M1Q1N4-1", "name": "Carbohydrate sulfotransferase", "aln": "------------MQKLHRHCLLLGAVFITMSFIVVFWDEVRVGPPYPRTNHRASS--------------------------------------------------------------------------------KHLAQFKLRQAHRKHLIKELCSANSSLNYRQKSITLD--------HLIVDDHHRVIYCYVPKVACSNWKRVMFVLSQNLKAPDGAPYLDPLDIPLEIIHNSTVHNTFKKLWMRHGRYARPLMHQKLKNYTKFLFVRDPFVRLISAYRDKFAEPNEYYYYKFGFMILQRYANISQPPTLAPEAFRAGIRPSFSHFIKFLLDPQTEKEKP--FDEHWKQIHRLCHPCQIDYDFIGKLETLDEDTEHLLKILGLDKHIHFPPGYENRTAVDWEQEWFANISLADRRELYSLYETDFKLFGYDKPETLLNE--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1RER3-1", "uniprot_id": "A0A8M1RER3_DANRE", "id": "A0A8M1RER3-1", "name": "Carbohydrate sulfotransferase", "aln": "------------MQKLHRHCLLLGAVFITMSFIVVFRDEVRVWPPYLRTNHRASS--------------------------------------------------------------------------------KHLAQFKLRQAHRKHLINELCSANSSLNYRQKSFTFDQIPDSSLNHLIVDDHHRVIYCYVPKVACSNWKRVMFALSQNLKAPDGAPYLDPHDMPLKIIHNSTVHNTFKKLWMRHGRYARPLMHQKLKNYTKFLFVRDPFVRLISAYRDKIAEPNEYYYYKFGSMILQRYANISQPPTLAPEAFRAGIRPSFNHFIKYLLDPQTEKEKP--FDEHWQQIHRLCHPCQIDYDFIGKLETLDEDTEHLLKILGLDKHIHFPPGYENRTAVDWEQEWFANISLADRRELYSLYETDFKLFGYDKPETLLNE--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M1PZ65-1", "uniprot_id": "A0A8M1PZ65_DANRE", "id": "A0A8M1PZ65-1", "name": "Carbohydrate sulfotransferase", "aln": "------------MQKLHHFCFLLGAVFITLFFIVVFWDEVRVG----TYQHMDSS--------------------------------------------------------------------------------KNLKQ---RQAHRKHLINKLCLANSSLLFRDKLITFDQIPNKALDHLIVDDRHRVIYCFVPKVACTNWKRVMIVLSQNLKAPDGAPYLHPLDIPIEVIHNSTVHKTFNNLWIHHGRYARPLMHQKLKNYTKFLFVRDPFVRLISAFRAKFNRPDEYFYSNYGSTMLQRYANISHPPASAQEAFSAGIRLSFTHFIQYLLDPQTEKEKP--FNEHWQQIHRLCHPCQIDYDFIGKLETLDEDTEHLLKILGLDKHIHFPPGNENRTAVDWEREWFANISVAHRRKLYSLYETDFKLFGYDKPETLLNE--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q498S0-1", "uniprot_id": "Q498S0_RAT", "id": "Q498S0-1", "name": "Carbohydrate sulfotransferase", "aln": "----------MTKPRLFRLWLALGSALMIL-LIIVYWDNVGTAHFYLHTSLSRPH--ILEPLPTQG------LAEENVLASDVDEFLDTLLSSDAKHNDLSRRKTEQPPVLTPSKPVLSHMEENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCAN-ASLAFPTKDRSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLD-RGSPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAP--FNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99LL3-1", "uniprot_id": "CHSTC_MOUSE", "id": "Q99LL3-1", "name": "Carbohydrate sulfotransferase 12", "aln": "----------MTKPRLFRLWLVLGSALMIL-LIIVYWDNVGTAHFYLHTSLSRPH--ILEPLPTQG------LVEENVFTSDVDEFLDTLLSSDAKHNDLSRRKTEQPPVPAPSKPVLSHMEENVRGYDWSTHDAHQNPDRDRQQAERRSLLRDFCAN-ASLAFPTKDRSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLD-RGSPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAP--FNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRFLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9NRB3-1", "uniprot_id": "CHSTC_HUMAN", "id": "Q9NRB3-1", "name": "Carbohydrate sulfotransferase 12", "aln": "----------MTKARLFRLWLVLGSVFMIL-LIIVYWDSAGAAHFYLHTSFSRPH--TGPPLPTPGPD----RDRELTADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPG-------SMEESVRGYDWSPRDARRSPDQGRQQAERRSVLRGFCAN-SSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKRVMIVLSGSLLH-RGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSFANFIQYLLDPHTEKLAP--FNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDRQLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A2R8QL27-1", "uniprot_id": "A0A2R8QL27_DANRE", "id": "A0A2R8QL27-1", "name": "Carbohydrate sulfotransferase", "aln": "MALSQSKSTKMGKSRLFRIFMIVGAVFMIL-LIIIYWDDVGASNFYLHTTISGPHPSRLSPQGRRGPEKKVEEDKESSFLTDIDAFVNQFLEGTADPTEQVRG--EPPPGDPHNQSSEKSDEKFVPRREWKIHLSPIDPEKKQKQENRKQLIQDVCGNKSVFDFPGKNRTFDDIPNKELDHLIVDDRHGIIYCYVPKVACTNWKRIMIVLSESLLV-DGVPYQDPLDVPQELIHNSSLHFTFNKFWKRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAYRNKFEQENEDFYKRFALVMLKKYSNYTDPPASVVDAFAAGIRPSFSNFVQYLLDPSTEKEMP--FNEHWRQMYRLCHPCQINYDFVGKLETLDEDAEHLLRILRVDNIVEFPESHRNRTVSSWEQDWFANIPLETRKELYRLYEADFKLFGYSKPEKLLHE--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VJG5-1", "uniprot_id": "Q9VJG5_DROME", "id": "Q9VJG5-1", "name": "Carbohydrate sulfotransferase", "aln": "----------MDQLVWLSFCISIGFSLLGNFSTGLPFEDGNNNNVK-------------------------------------------------------------------------------------------ITRRSLELTQTINIQRQEFMQRQCELLGDHTQTLEDLSELQMDHMIVDKEHKLLYCYVPKVACTNWKRVLMMLTNKWHN-----GTDPLQIPGSLAHSVGMFTKLYDLSEAE------QQQVLSDEYTRFILVRHPLERLLSAYRNKLEGDSP--SARYFQSRVGRQIVKELRPGASNNSLERGDDVSFGEFIQYLVTPELSRANQSDYNEHWEVIAKLCNPCVMKYNVVGKYDTLLDDSALALYLAGADN-LTFPTGHKPSSTRANLRNYFDPLPIGAIRKLYDIYEDDFRLFDYALDEVLGFEFG", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : :* :: : :. . . : . : ::: *:***..* :**:******:****::: *: . .* :* . *. . .: .: : .:**:*::**.*: **:**:* *: . .: : * ::: * ** .*:::*: * .: ::***. : :**:** :.*:.:** :** :*: * * : ** . . :. .::* :.: ::** :** ** **.* * * : ", "identical_positions": 70, "similar_positions": 90, "identity": "15.77%" }, { "cls_id": "homologset.agr.HGNC:17425", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9EP86-1", "uniprot_id": "NPFF1_RAT", "id": "Q9EP86-1", "name": "Neuropeptide FF receptor 1", "aln": "----------------------------------------------------------------------------------------------------------------------------------ME--------AEPSQPPNGSWPLGQNGSDVETSMATS---------------------------LTFSSYYQHSSPVAAMFIAAYVLIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALFTIAVIWALALLIMCPSAVTLTVTREEHHFML--DARNRSYPLYSCWEAWPE-KGMRKVYTAVLFAHIYLVPLALIVVMYVRIARKLCQAPGPARDTEEAVAEGGRTSRRRARVVHMLVMVALFFTLSWLPLWVLLLLIDYGELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYFNENFRRGFQAAFRAQLCWPPW-----------------AAHKQAYSERPN--------------RLLRRRVVVDVQPSDSG----LPSESGPSSGVP--GPGRLPLRNGRVAHQDGPGEGPGCNHMPLTIPAWNI------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "E9Q468-1", "uniprot_id": "E9Q468_MOUSE", "id": "E9Q468-1", "name": "Neuropeptide FF receptor 1", "aln": "----------------------------------------------------------------------------------------------------------------------------------ME--------AEPSQPPNGSWPPSLNESDAETAPVAS---------------------------LTFSSYYQHSSPVAAMFIAAYALIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALLTIAVIWALALLIMCPSAVTLTVTREEHHFML--DARNRSYPLYSCWEAWPE-KGMRKVYTAVLFAHIYLAPLALIVVMYARIARKLCQAPGPARDAEEAVAEGGRASRRRARVVHMLVMVALFFTLSWLPLWVLLLLIDYGELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYFNENFRRGFQAAFRAQLCWLPW-----------------AAHKQAYSERPG--------------RLLRRRVVVDVQPSDSG----LPSESGPSSGVP--GPNRLPLRNGRVAHQDGPREGPGCNHMPLTIPAWNI------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9GZQ6-1", "uniprot_id": "NPFF1_HUMAN", "id": "Q9GZQ6-1", "name": "Neuropeptide FF receptor 1", "aln": "----------------------------------------------------------------------------------------------------------------------------------ME--------GEPSQPPNSSWPLSQNGTNTEATPATN---------------------------LTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMV--DARNRSYPLYSCWEAWPE-KGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADP--RASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPS-----------------GSHKEAYSERPG--------------GLLHRRVFVVVRPSDSG----LPSESGPSSGAP--RPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58GKB8-1", "uniprot_id": "A0AC58GKB8_DANRE", "id": "A0AC58GKB8-1", "name": "Neuropeptide FF receptor 1", "aln": "----------------------------------------------------------------------------------------------------------------------MYLVSSQNCFALMEGSETVGLWADISICVFSNIHCTNQTNVTNSSTMAG---------------------------IILSPYYQHSLPTAALFTLAYLFIFLLCLMGNALVCVIVLRNRHMRTVTNIFILNLAVSDLLVGIFCIPTTLVDNLITGWPFSNTVCKLSGLVQGMSVSASVFTLVAIAVDRFRCIVYPFKPKLTLFIAKVSIGTIWLLALTIMFPSVLMLTVEQERAHFMIYNDDYNNTYPLYSCYETWPD-PEMRKIYTTVLFIHIYVIPLALIMLMYGRIGAKLYSAA----VSEHANAQ----GKRKIRVVKMLIMVALLFMLSWLPLWTLMMLTDYGHPDNDSLEILTSYIFPLSHWLAFSNSSVNPIIYGYFNENFKRGFQAVFQRQACFRRRRKMR----------FRVKRPRQGCSPLNT--------------GVLGSKTNRIFTESDLTGCVRLELEHRRASTIENKAEGGNSGSSGRREIHFEEIEKVSSVGGKIYN-AWEH------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q8IN35-1", "uniprot_id": "SIFAR_DROME", "id": "Q8IN35-1", "name": "Neuropeptide SIFamide receptor", "aln": "MMAASGRIRKRKHKSHTSGDVPSTTTSVPMPIPTMAPGKMVAETMEEAAALAGDYNNFTHNFVDLQNLLSFNELNGTSGSGGTAVSSLGSSSAIKLNNSAITDTLLGTVLTTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ-MTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSD-ALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDR--MQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILY-SVNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEARRSAGHGLNDTLVDRDSVSMDVGRRQGATPSSLLDKRQKFVKQDSVISFVDQRPEQRRHQLVKQDSVISFADQRRGLLHKQDSLMANRTGDAPTHHVSILKKTDSQLSYGSSTSPRRNADLYE", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * . . : : : : :.. *:*: . : :: ** .:**: ::**::* :**: :*:**** **:***::*:** :**:*:**:.*::. * :. **: :**:**:***::*:*::::** .* *:: :* * . * ** :** * : : : . * : * : * *.** . : . : *: *::** : * * *: . : : : :*::**: *.::* ******:.:: .:* . : :*.::**. :*. ***:* .*::::*** * :: : * . * * : *: * : : . . .* . . . ", "identical_positions": 99, "similar_positions": 120, "identity": "12.98%" }, { "cls_id": "homologset.agr.HGNC:17427", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q92784-1", "uniprot_id": "DPF3_HUMAN", "id": "Q92784-1", "name": "Zinc finger protein DPF3", "aln": "MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVD--AREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCD--------------ICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8I6AL27-1", "uniprot_id": "A0A8I6AL27_RAT", "id": "A0A8I6AL27-1", "name": "", "aln": "MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVD--AREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCD--------------ICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P58269-1", "uniprot_id": "DPF3_MOUSE", "id": "P58269-1", "name": "Zinc finger protein DPF3", "aln": "MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVD--AREEESIQEIQRVLENDENVEEGNEEEDLEEDVPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCD--------------ICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A9LMC0-1", "uniprot_id": "DPF3_DANRE", "id": "A9LMC0-1", "name": "Zinc finger protein DPF3", "aln": "MATVIQNPLKALGDQFYREAIEHCRSYNARLCAERSVRMPFLDSQTGVAQNNCYIWMEKRHRGPGMAAGQMYTYPARCWRKKRRLHTPLDPQLRLCELRLEAELMAKREAPQTEATALEALLRGDGILDKRNNNAKEEETLLEIQRVLEADENGDGFHDDEDFEVDTPKRKHRNKGRGRGS--GRRRTEAVANDDQDKPYVCDNRYKQKHNSKTADSVCGKRYKNRPGLSYHYAHTHLAEEEGEEERETEIPQSPPVHHENHKPQKAPDGSIIPNDYCDFCLGDSGSNRKTGQAEELVSCSDCGRSGHPSCLQFTDNMMQAVRTYQWQCIECKSCSLCGTSENDDQLLFCDDCDRGYHMYCLKPPMTQPPEGSWSCHLCQNLLKDKASGVEDP-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****:***********:**********:*********:**************************:*.**:***************.* **:*** *:: *.** *::. :*:*:*******:*: .* : *:***:: ******* *** : :::**:* * ****:*.:**.*** **** :*.:::*:******* :*********************.***:* :: * ..* ::***:***.***::***:*******.*. *:*:*:.******:********:***** ** :**:**:********* **************************:**:::*********** :***:***.. ", "identical_positions": 271, "similar_positions": 73, "identity": "68.78%" }, { "cls_id": "homologset.agr.HGNC:17428", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8J8XFA0-1", "uniprot_id": "A0A8J8XFA0_RAT", "id": "A0A8J8XFA0-1", "name": "", "aln": "------------------------------------------------------------------------------------------------------------------------MKPLEKFLKKQTSQLAGRAVAGGPGGGPGCCGGPGGGGGSGGGGGPTGGLRPLQRRQSVSRLLLPAFLREHPT------------------------------------------------------------------DPGLEPPVEEE------------------GGEPLGVSEEPGSGGPCWLQLEEVPGPGPIGSGVPLRSPSSYSSDE---------------------LSPGEPLASPPWAPLGAPERPEHLLN-------------------------------------------------------------------------------------------------------------------RVLERLAGGTTRDSSSASDILLDDIVLTHSLFLPTEKFLQELHQYFVQSK----NVEGPEGLGRKQACLALLLHFLDTYQGLLQEE-EGAGHIIKELYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRIDS--CLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAEREDALILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEIQASP-GDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFESLTDPCRNHKSYREVISKMKP---PLIPFVPLILKDLTFLHEGSKTLVDG--LVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNHLFELSYKLEANSQ--", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q68EF8-1", "uniprot_id": "RPGFL_MOUSE", "id": "Q68EF8-1", "name": "Rap guanine nucleotide exchange factor-like 1", "aln": "------------------------------------------------------------------------------------------------------------------------MKPLEKFLKKQTSQLAGRAVTGGPGGGPGCCGGPGGGGGPGGGGGPAGGLRPLQRRQSVSRLLLPAFLREPPT------------------------------------------------------------------EPGLEPPVEEE------------------GGEPLGVSEEPGSGGPCWLQLEEVPGPGPIGSGVPLRSPSSYSSDE---------------------LSPGEPLASPPWAPLGAPERPEHLLN-------------------------------------------------------------------------------------------------------------------RVLERLAGGTTRDSS-ASDILLDDIVLTHSLFLPTEKFLQELHQYFVQSR----NVEGPEGLGRKQACLALLLHFLDTYQGLLQEE-EGAGHIIKELYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRIDS--CLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAEREDALILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEVQVSP-GDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMKP---PLIPFVPLILKDLTFLHEGSKTLVDG--LVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNHLFELSYKLEANSQ--", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UHV5-1", "uniprot_id": "RPGFL_HUMAN", "id": "Q9UHV5-1", "name": "Rap guanine nucleotide exchange factor-like 1", "aln": "------------------------------------------------------------------------------------------------------------------------MKPLEKFLKKQTSQLAGRTVAGGPGGGLGSCGGPGGGGGPGGGGGPAGGQRSLQRRQSVSRLLLPAFLREPPA------------------------------------------------------------------EPGLEPPVPEE------------------GGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDE---------------------LSPGEPLTSPPWAPLGAPERPEHLLN-------------------------------------------------------------------------------------------------------------------RVLERLAGGATRDSA-ASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAG----GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDS--CLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSP-GDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKP---PVIPFVPLILKDLTFLHEGSKTLVDG--LVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ--", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7FGN2-1", "uniprot_id": "E7FGN2_DANRE", "id": "E7FGN2-1", "name": "", "aln": "--------------------------------------------------------------------------------------------------------------------MPAGMKPLEKFLKKQTNALTR----------------------AGGFGEKATGTGASRRRASLSRVVP--FFRETSP------------------------------------------------------------------ESGPAREVFSP------------------ETEEA----------PCWP-----------SATADIRSPS-LSSDE---------------------QSSEASLDTN-WTPLPA-DTPENLAL-------------------------------------------------------------------------------------------------------------------ALLDSVAG--KRYAN-CTEILLDDFMLTHPIFLAPDKFQQVLLQQFSSEGKQGEGWPGWDGAERKLAVLTVAFRYLDTYRDLLQEEGDRSNTFPKELYLCAVDELNRFPELVEDVLKLQRWTEILHSPAEEDKESRKKQVRPLFRHFRRIDA--CLQPREAFRGSDEIFCRVYTPDHSYVTIRSRLSCRVGEILALVKEKLQYSEDQPTQPANLILVAVTSSGEKAVFRPSDEAVFTTLGVNTHLFACEPAELESLIPLPEEIHWTP-GDSKLHDMSAEEVANQLVVFDWELFSCVHEVEFVCYVFHGEQARWRPLNLELILQRCSEVQHWVATEILQCQSLPKRIQLLRKFIKIAALCKQQQDLLSFLALVLGLDNPAVSRLRLTWEGLPGKFRKQFQQFESIADPSRNHKSYRDLLASLRA---PLIPFTPLLLKDLTFLHESCKTFHGE--LVNFEKMHKVAEMVRSIRRYRSSQLAMEAEPSPSHLQTKAYVRQLQVIDNQNLLFEMSSKLEPKDM--", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1Z6P8-1", "uniprot_id": "A1Z6P8_DROME", "id": "A1Z6P8-1", "name": "", "aln": "MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAH--EDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGP----EDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP---PLIPFMPLLLKDMTFAHEGNKTSLDG--LVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P25300-1", "uniprot_id": "BUD5_YEAST", "id": "P25300-1", "name": "Bud site selection protein 5", "aln": "------------------------------------------------------------------------------------------------------MSPKNKYVYICVEYIYIYFAKIHKQSTLSSDTTKMFVLIDNVLAYLLEQDDLFVTARFAIQGQIVSRRVNKIHISNITDVLLQQFISHTLPYN----------------------------------------------------------------DNIVPKKILDS-------------------------------------MRTAVRQLLEATACVSRECPLVKRSQD---------------------IKRARKRLLSDWYRLGADANMDAVLLVVN--------------------------------------------------------------------------------------------------------------SAWRFLAVWRPFVNSIQHATQELYQNIAHYLLHGNVNIQRVTALIQLVMGQD------DLLFSMDDVLQEVFRIQLYLNKMLPHNSHKWQKPSPFDSANLLLNFRDWTTDNALLQELLLSYPTINKNKHKNHSVPRLIQIWVESYWQDSETTLK-DILNFWYSHLAEYYEYQELFADIVQLFINKKRTRQLKIHYIGLTDKEIEENKPPLDYENLFLQYEIDKTN-------ANDELCGATDLSDLLFQWKQGELLEVEAFALN-------------VSPWSLAKTLTLLESSLYLDIETIEFTRHFKHN------DTTIDSVFTLSNQLSSYVLETTLQQTHT------ISYWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPIDVKS---DHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIRDGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSNTTARSLLGAMIKVHTLYNDNKDRAYQVSIAKVPRLT", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . . . : . : . . : : . . *.: . : * : : : : : ::: : * : . . :::. . . . : : : . . . . . . .:: : . . .::: .. :: : ... : : .:. ** : : : :.. .:* :. :. .*: :. *: : .:: .: .:: :: : : ::::* * ::* :: ::: .*.* ::.** . : . : *:.:: : .* .*:. ** : : * :** .*:::*:** ::. .* **::*:: ::: : : :. . . . : ..:.: *:. . .: ", "identical_positions": 32, "similar_positions": 164, "identity": "3.14%" }, { "cls_id": "homologset.agr.HGNC:17429", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A8I6A4L9-1", "uniprot_id": "A0A8I6A4L9_RAT", "id": "A0A8I6A4L9-1", "name": "Cingulin", "aln": "-----MMADPRGPVDHGVQIRFITEPEGA-----AEMGTLRRSGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGADSFGVQIKGGNNRGSPGALSSDSELPENPYSQVKGYPATSQGSTSDEEPRDHLNGKLLRSQSQASLTGLALMSPSNRSTSLLELAPQKTPSVNTIDTAPLSSVDSLINKFDGQKGSQVRGRTGRRTKTLP-QEQQRKRSQSLDSRLSRDTREDRELQSTNHWARGTKYDNHMDSSKTLPQKQ--SPFSSFSRSRQTQDWVLQSFE----ESREKVQDPAMVQFKSTPDLLRDQREAAPPGSADHMKATIYG---ILREGSADSEASVRRKVSLVLEQMQPLGMVSPASTKALVGQAELTRKMEELQKKLDEEVKKRQKLEPSRIG-------------LERQLEEKAEECHRLQELLEKRKGEVQQSAKELQNMKLLLGQEEGLRHGLETQVKELQLKLKHSQNLDPGKESLLKDLLETRELLEELLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRLQYQRDTEQLRRSMQDATQDHAAVEAERQKMSSLVRELQKELEETSEETGHWQNMFQKNKEELRAAKQELLQLRMEKEEIEEELGEKMEILQRDLEQARASTRDTQQVEELKKELQRTQGELKELQAERQSQEVAGRHRNQVLEKQLSVLRAEADRSRDLEEQNLQLQKTLQQLRQDCEEASKAKVASETEAMVLGQRQATVETTLRETQEENDEFRRRILGLEQQLKEARGLVEGGEAVEARLRDKVHRLEVEKQQLEEALNVAQEEEGSLAAAKRALEIRLEEAQRGLARLGQEQQALNRALEEEGKQREALRKSKAELEEQKRLLNRTVDRLNKELEQIGDDSKLALQQLQSQMEDYKEKARKEVADAQRQAKDWASEAEKNSGGLSRLQDELQRLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDKARQLKSLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGLQKPSASFSQLESQNQLLQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLTLRVKALKRQVDEAEEEIERLDSLRKKAQRELEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKQEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P59242-1", "uniprot_id": "CING_MOUSE", "id": "P59242-1", "name": "Cingulin", "aln": "------MADPRGPVDHGVQIRFITEPEGA-----TEMGTLRRSGRRPARDARASTYGVAVRVQGIAGQPFVVLNSGEKGTDSFGVQIKGGNNRGSPGALSSDSELPENPYSQVKGRPATSRSSTSDEEPKDHLNGKLIRSQSQASLTGLAFMSPSNRSTSLLELAPKPTSSINTIDTAPLSSVDSLINKFDSQKGGQVRGRTGRRTRTLP-HEQ-RKRSQSLDSRLPRDTREEREHQSANHWTRGTKYDNHVDSSKNPSQKQ--SPFSSFSRSRQTQDWVLQSFE----ETR----DPAMVQFKSTPDLLRDQRETAPPGSADHVKATIYG---ILREGSSESEASVRRKVSLVLEQMQPLGMVSPASTKALAGQAELTRKMEELQKKLDEEVKKRQKLEPSRVG-------------LERQLEEKAEECHRLQELLERRKGEVQQSSKELQNMKLLLGQEEGLRHGLEAQVKELQLKLKHSQSPDSGKESLLKDLLDTRELLEELLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRLQYQRDTEQLRRSMQDATQDHAALEAERQKMSSLVRELQRELEETSEETGHWQSMFQKNKEELRATKQELLQLRMEKEEMEEELGEKMEVLQRDLEQARASTRDTHQVEELKKELRRTQGELKELQAEQQNQEVTGRHRNQVLEKQLAALREEADRGRELEQQNLQLQKTLQQLRQDCEEASKAKVASETEAMMLGQRRATVETTLRETQEENDEFRRRILGLEQQLKEARGLAEGGEAVEARLRDKVHRLEVEKQQLEEALNAAQEEEGNLAAAKRALEVRLDEAQRGLARLGQEQQALNRALEEEGKQREALRRSKAELEEQKRLLNRTVDRLNKELEQIGDDSKLALQQLQAQMEDYKEKARKEVADAQRQAKDWASEAEKNSGGLSRLQDELQRLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRFQDDKARQLKSLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLTLRVKALKRQVDEAEEEIERLDSLRKKAQRELEEQHEVNEQLQARIKSLEKDAWRKASRSAAESALKQEGLSSDEEFDNVYDPSSIASLLTESNLQTSSC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9P2M7-1", "uniprot_id": "CING_HUMAN", "id": "Q9P2M7-1", "name": "Cingulin", "aln": "MEQAPNMAEPRGPVDHGVQIRFITEPVSG-----AEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLP-PEQ-RKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYG---ILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVG-------------LERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q1L8T5-1", "uniprot_id": "CING_DANRE", "id": "Q1L8T5-1", "name": "Cingulin", "aln": "--MSSLSADRKPPLDYGVQIRFIKDLDDAGGGFPDKSRLANGVGGVSNGTSSPSKYGVAVRVQGISGQPYVVLQDGEKG-DSYGVQLKTQPQIQSAPPVVSQTSPYNTLLLGQREGARTPQGSYNPTDQPSSPDEDFGSPLRRPPGDGQAGTQGEAEPRTTERFTPSALAPKLDKKDNDAFNEAGLRKVKQNGIGSSLNGTGLNGSFPPPSSAQDEDQAPAIDTKSLAPINKLISRFGGGGGGSGDILNSEAQTRPRLDNRVRSQSADALNKPSEEASSTSPTINPYAPNTSATVPKLNSTKPSSTGSLGRDATSVAKVAAIPNFKPLAFNQSPKLFAPKEAPPAVPKKPVTPDLIKSQTTSIENGNGEDDQTKQAIYN-ILKEGSIEKEEAIKRKASLIHERFCGVKAPQISVTDSNMKTELEQAFGRNTQLQQQLDKSRRELQENQDQMVELRMDREGAESRLRQQEDQLAQLQEELRRTLENSPQSDSMQLDLLTVQAELSESQLLRQKLEDTLRQRERELTALKGALKDEVASHDKEMEALREQFSQDMDALRHSMETVSQSQLEIEEERQKVNASILAMEEELEGYKEQSEQWKKQFS-------SANQELLKAQQGKRELEEKL------------LAVVKQTDETDSNSVMKELQQCRDSLKKAQSELEKQ------KAETLKKQEELKSATRASEKRETELKAEIDRLINQLKKEKEELSKAIEKTQQPLVSDQTKDPESNLELQEAN-------------------------------ARLRERIARMTRLHSSVPDSSSSDALEE-----ENRSLKTQLEESRRAASRLGVEKEELNRRLEEREREREALRRGKSDLEEQKRLLDRSLDKINKEMESMMGDSRQSVQVLQSQLEEFRDRSRRELQDAQRLSKDRLVELQRAQALLKTTQEEVSRVKKELLSCTEERDSTQLDKELLSSRLKNMETELQTDRSSQTDRSREIRLLEDKVKTLEIELDEEKSGAELLNERITRCREQVDQLRSELMQERSARHDLEMDKSALERQIKELKSRIADMGTQSRPSAGVTMLENKVQELEDRLRSEEREKNTIQAAQRRLDRKLKDVTATLDQERNQHAEQRDQLSLRVKALKRQLDESEGEVERLEGVRRKVLRELEEQRELQAALQAKVNAMDNELRKIQQ---SRRSTLGSTLSSDEE-DNYSDTKSITSILTDSPLQTTSC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus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identical_positions": 352, "similar_positions": 414, "identity": "28.62%" }, { "cls_id": "homologset.agr.HGNC:1743", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O08837-1", "uniprot_id": "CDC5L_RAT", "id": "O08837-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAS-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRR-------------------------------LECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q6A068-1", "uniprot_id": "CDC5L_MOUSE", "id": "Q6A068-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAS-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRR-------------------------------LECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A1W2P855-1", "uniprot_id": "A0A1W2P855_MOUSE", "id": "A0A1W2P855-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAIMKYRKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRR-------------------------------LECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A1W2P7H4-1", "uniprot_id": "A0A1W2P7H4_MOUSE", "id": "A0A1W2P7H4-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAIMKYRKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRR-------------------------------LECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A1W2P7Z8-1", "uniprot_id": "A0A1W2P7Z8_MOUSE", "id": "A0A1W2P7Z8-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRR-------------------------------LECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A1W2P6Q8-1", "uniprot_id": "A0A1W2P6Q8_MOUSE", "id": "A0A1W2P6Q8-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRR-------------------------------LECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A1W2P7S8-1", "uniprot_id": "A0A1W2P7S8_MOUSE", "id": "A0A1W2P7S8-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKMRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAP-QDRILQEAQNLMALTNVDTPLIGGLNTPLHESDFSGVTPQQQVVQTPNTVLSTPLRTPSNGAEG-----LTPRSGTTP-----KPVTNATPGRTPLRDKLHINPEDGMADHSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQATRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPFDVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNDSEHITYLEHSPYEKFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSCYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRR-------------------------------LECLEEDVQRQQEREKELQQRYADLLMEKETLQAKF---------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99459-1", "uniprot_id": "CDC5L_HUMAN", "id": "Q99459-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRG---VDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPAS-QDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEG-----LTPRSGTTP-----KPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRR-------------------------------LECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF---------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0AC58HMF3-1", "uniprot_id": "A0AC58HMF3_DANRE", "id": "A0AC58HMF3-1", "name": "Cell division cycle 5-like protein", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHMAKLMPTQWRTIAPIIGRTAAQCLEHYEYLLDKAAQRENEDDVGDDPRKLKPGEIDPNPETKPARPDPVDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIDIQKKRKKKRG---VDYNAEIPFEKKPAQGFYDTSMEQYDPLEPDFKRLRQQHLDGELRSEKEDRDRKKDRQKIKKKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELEEVVKLGQASEIARQTAEESGITNSASSALLSEYNVTNNSMALRTPKTPAA-QDKILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSHTGEG-----LTPHGGLTP-----KASVGVTPGRTPLRDKLNINTEEGGVDYTDPSFSKHMQRESREHLRLGLMSLPVPKNDFEIVLPENAEKELEETEVDESFVEDAAEIELRKQAVRDAEREKELRQRHTSVQRDLPRPSEVNETILRPHNVEPPLTDLQQAEELIKREMITMIHYDCLHHPF--SDAKKTKGVNSSSNNAEHISYLEKTPYEKVSEEELKKAGDLLLQEMEVVKHGMGHGDLSMEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIDSLEKKLEMNRGHMTAEAKRAAKMEKKMKILLGGYQSRAMGLLKQLSEVWDQLEQANLELHTFMELKKQEDLAIPRRQEVRIYTHTPHSGHPTQTRGAHIHTHTTLWPFHTDKGDAHIHTHHTLAIPHRQEVRIYTHTTLWPFHTDKRCTYTSRSIQHSIIAHLA", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W0R0-1", "uniprot_id": "Q9W0R0_DROME", "id": "Q9W0R0-1", "name": "", "aln": "MP--RIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAGIGSGN-RKRIKG---IDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERERKRDKQKLKQRKENEVPTAMLQN---MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIET--TDALLADYSIT--PQVAATPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHESDFSGVLPKAASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETNS-EPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQLQ---------SYFKANPYEDISQQELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNRRHMAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAVPRR-------------------------------LESLQEDVRRQMDREKELQQKYASLVEERDSLYSQIEHITG--VRPTAQQLLPDQEA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q03654-1", "uniprot_id": "CEF1_YEAST", "id": "Q03654-1", "name": "Pre-mRNA-splicing factor CEF1", "aln": "MPPVPIYVKGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNPKLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLESED--SGGAALSTGVTDLKAGDINPNAETQMARPDNGDLEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRRELKQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQ-IKKKFEQFERKVNRKGLDGNKDKPSKKNKDKKRKHDENEHVEKAALGESTTLTDEYKKPKLILSAPGTKQGKVTYKKKLESKRQKLIEAQATG--------------------------------------------------------------------------------TVLTPKELLPHDSGQE---------------------------------DNERSNIKSG----------KQLKSRIRKFLVQMFASLPSPKNDFEIVLSEDEKEE------------DAEIAEYEKEFENERAMNEEDNFIEPPSQNDAPRVSLVAVPLAYSTLPIPEFKNNPQS--------------------------------------------AIDNKYNLLVANAINKEPHMVPEDTVDFLKEVES------------------------RMQHITQGRTSMKIQFKTAMPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQRKYYADYYAYRQEIRSLEGR-------------------------------------------------RKRLQAMLNSSSSI-------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** * :***** *.**:*****: ** .:***::****::*:*:*.: ** *:*:*.:: **:*:**: :**.:*: :*.****** ::.*.* *:*:*: **: .. . .**.*:*:**.**: **** *::::* ***:****** *******.** **: ***::*:* *******: *** : : : :*** :* :*: * *:**** *. : . .*.::.:: * .:*: .:* . :: *: ::..: .* * *:.**:*.:* .: :: *: : : . **::. . . *: * :.. *: : . :. * : ** *:**:***:.*: :.* * : . .: .* . *.. ** : * : . :.: :: . *: . : : * : :: . . : : : . :* * ::.: * : :.: ::::*:: : * . . . : : . : .:* :: * :: : :: ", "identical_positions": 160, "similar_positions": 186, "identity": "18.39%" }, { "cls_id": "homologset.agr.HGNC:17432", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6RY07-1", "uniprot_id": "CHIA_RAT", "id": "Q6RY07-1", "name": "Acidic mammalian chitinase", "aln": "-------------------------------------------------------------------MAKLILVTG--LVLLLNVQLGSAYN--------------------------------LVCYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQN---NQITTIEWND------------------------------VTLYKAFNDLKN--RNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQ--DKHLFTVLVKELREAFEQEAIESNRPRLMVTAAVAAGISNIQAGYEIPELSQYLDFIHVMTYDLHGSWDGYTGENSPLYKLPTETGSNAYLN----VDYVMNYWKDNGAPAEKLIVGFPEYGHTYILSNPSDTGIGAPTS-----GNGPAGPYTRQAGFWAYYEICTFLRNG---ATQDWDAPQEVPYAYKGN-------EWVGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCD------------------------------------------------------QGKFPLTSTLNKALD----------IPTAGCTAPDLPSEPVTTPP---GSGSGGGSSGGGSEGSGFCA---------------------GKADGLYPVADDRNAFWHCINGITYQQHCQAGLVFDTSCNCCNWP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91XA9-1", "uniprot_id": "CHIA_MOUSE", "id": "Q91XA9-1", "name": "Acidic mammalian chitinase", "aln": "-------------------------------------------------------------------MAKLLLVTG--LALLLNAQLGSAYN--------------------------------LICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQN---NEITTIEWND------------------------------VTLYKAFNDLKN--RNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQ--DKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLN----VDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTS-----GDGPAGPYTRQAGFWAYYEICTFLRSG---ATEVWDASQEVPYAYKAN-------EWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCD------------------------------------------------------QGKFPLTSTLNKALG----------ISTEGCTAPDVPSEPVTTPP---GSGSGGGSSGGSSGGSGFCA---------------------DKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BZP6-1", "uniprot_id": "CHIA_HUMAN", "id": "Q9BZP6-1", "name": "Acidic mammalian chitinase", "aln": "-------------------------------------------------------------------MTKLILLTG--LVLILNLQLGSAYQ--------------------------------LTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQN---NEITTIEWND------------------------------VTLYQAFNGLKN--KNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQ--DKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLN----VDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTS-----GAGPAGPYAKESGIWAYYEICTFLKNG---ATQGWDAPQEVPYAYQGN-------VWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCN------------------------------------------------------QGKFPLISTLKKALG----------LQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCA---------------------VRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "O35744-1", "uniprot_id": "CHIL3_MOUSE", "id": "O35744-1", "name": "Chitinase-like protein 3", "aln": "-------------------------------------------------------------------MAKLILVTG--LAILLNVQLGSSYQ--------------------------------LMCYYTSWAKDRPIEGSFKPGNIDPCLCTHLIYAFAGMQN---NEITYTHEQD------------------------------LRDYEALNGLKD--KNTELKTLLAIGGWKFGPAPFSAMVSTPQNRQIFIQSVIRFLRQYNFDGLNLDWQYPGSRGSPPK--DKHLFSVLVKEMRKAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKDGYTGENSPLYKSPYDIGKSADLN----VDSIISYWKDHGAASEKLIVGFPAYGHTFILSDPSKTGIGAPTI-----STGPPGKYTDESGLLAYYEVCTFLNEG---ATEVWDAPQEVPYAYQGN-------EWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCH------------------------------------------------------QRHFPLTSTLKGDLN----------IHSASCKGPY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q91Z98-1", "uniprot_id": "CHIL4_MOUSE", "id": "Q91Z98-1", "name": "Chitinase-like protein 4", "aln": "-------------------------------------------------------------------MAKLILVTG--LAILLNVQLGSSYQ--------------------------------LMCYYTSWAKDRPTEGSFKPGNIDPCLCTHLIYAFAGMKN---NEITYLSEQD------------------------------LRDYEALNGLKD--RNTELKTLLAIGGWKFGPAPFSSMVSTPQNRQTFIKSVIRFLRQYNFDGLNLDWQYPGSRGSPPK--DKHLFSVLVQEMRKAFEEESTLNHIPRLLLTSTGAGFIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKNGYTGENSPLYKSPYDIGKSADLN----VDSIITYWKDHGAASEKLIVGFPAYGHTFILSDPSKNGIGDPTV-----SAGPPGKYTNEQGLLAYFEICTFLNEG---ATEIFDATQEVPYAYLGN-------EWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCH------------------------------------------------------QGRFPLTTTLKRDLN----------VHSASCKASYRGEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1M559-1", "uniprot_id": "F1M559_RAT", "id": "F1M559-1", "name": "", "aln": "-------------------------------------------------------------------MAKLILATG--LAILLYAHLGSSYQ--------------------------------LMCYYTSWAKDRPTVGSFKIGNIDPCLCTHLIYAFAGMRN---NEIINTSEQD------------------------------LIDYEAINYLKD--RNTELKTLLAIGGWKFGSAPFSAMVSTPQNRQTFIKSVIKFLRQYKFDGLNLDWQYPGSRGSPPK--DKHLFSVLVQEMRKAFEKESTEQEIPRLLLTATVAGVIDTIQSGYKIPELSQSLDYFQVMTYNLHDFQNGYTRENSPLYQSPSDTGIYAYLN----VDAIISYWKDNGAAREKLIVGFPAYGHNFILSDPSNTGINAPIV-----STGPPGKFTGEAGLWAYYEICTFLNDG---ATDLWDGPQEVPYAVQGN-------VWVGYDNVKSFKIKAQWLKDNKLGGAMVWPLDMDDFTGSFCQ------------------------------------------------------QGRFPLTSTLKHYLG----------VQSTNCMA-YKEEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "A0A0G2JDS2-1", "uniprot_id": "A0A0G2JDS2_MOUSE", "id": "A0A0G2JDS2-1", "name": "", "aln": "-------------------------------------------------------------------MTKLILVTG--LALLLNPQLGSAYQ--------------------------------LMCYYNNVAQNRPKLGSFNPADIDPCLCTHLIYAFAGMQN---NKVTMRSMND------------------------------LTDYQALNTLKS--RNVQLKTLLAIGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSR--DKHLFTVLVQKIREAFELEAIENKSPRLMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGYTGENSPLYKSLNDTGINTLLN----VDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTA-----SAGTLGPYTEESGTWAYYEICSFLNDG---ATEAWDSAQEVPYAYQGN-------KWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCN------------------------------------------------------QGQFPLTSTLKNALL----------VYSTSCMASVSDLQQVNAPLY---SGNRNWKRGSKAMDS------------------------------VSPVPRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D4A2D4-1", "uniprot_id": "D4A2D4_RAT", "id": "D4A2D4-1", "name": "", "aln": "--------------------------------------------------MLYKTSEDPAGSVLRAFISKLVFIMG--LNLLLNVQLDSAYQ--------------------------------LMCYFNNWPQYQPDVRGMKLDDIDPCLCTHLIYSFAGIWE---NNNTMTKRKD------------------------------LDDYKEFNDLKK--RNNKLKTLLSIGCWNFEAGLFITMVSTPESRHTFITSVRKFLRKYGFDGLNLAWQYPGCYGSPPK--DKHLFTILTQEIRKAFEKEVSKNKKSRLIITAALAGVISPIQFGYHVPQLSQSLDYIQVMTYDLHGSWDGYTGENSPLYKSPAETGVKAFYN----IKYTMHNWKNKGVSPEKLIVGFPAYGHTFILSDSTKTEIGAPSN-----RGGHPGPYTKKTGFWAYYEICAFLKNG---AIQVWNAAQQVPYAFHGN-------EWVGYDNVKSFHIKAQWLKNNNFGGAMIWAIGMDDYTGSFCD------------------------------------------------------QGPFPLTSTLKNALK----------VHSASCKVTALSAN---------VTGSRDSNFG--------------------------------ALEPLFQLSSK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VZV2-1", "uniprot_id": "Q9VZV2_DROME", "id": "Q9VZV2-1", "name": "", "aln": "MFPPRLLRIAFVICLLIVLLSPSADSAQTKTRRRLRRPTTSVSSSRSNLIESKKSTEAPEAEKRIDQITSATTTSARRTRLRSKAKLGAAAAGGAAVAAGGTALVASGSSLKGKKTKVDDGTPKIVCYYTNWSQYRVKIGKFVPEDIPADLCTHIIFAFGWLKK---NKLSSYESNDETK------------------------DNVPGLYERMMTLKK--ANPKLKILLALGGWSFGTQKFKDMSSTRYTRQTFVYSAIPFLRKRGFDGLDMDWEYP--KGS--D--DKKNFVLLLKELREAFEAEAQELKKPRLLLSAAVPVGPDNIRGGYDVPAIASYLDFINLMAYDFHGKWERETGHNAPLYAPSTDSEWRKQLS----VDNAASLWVKMGAPKEKLVIGMPTYGRSFTLANPDKHGPNAPAS-----GGGREGVYTKEGGFLAYYEICEMLLNG---AVYVWDDEMKVPYLVDGD-------QWVGFDDERAIRNKMHWIKSNGFGGAMVWTIDMDDFKGEVCGG-----------------------------------------------------NVKYPLIGAMREELLGISRGKEAKDVNWTAVAATFEDIEEKPEPIKISVDEILNKVRKPQVQKKQRIK---------------------SGANAVASNTRPAQVFCYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQDYKLTEATDDDPENYESVIALRDNNPDLQILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIDFLRDYKFNGLDVDWEYPRGAEDRVAYVSLLKELRVAFEGEAKSSGLPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWERTVGHNSPLFALESATGYQKKLTVDYSAREWVKQGAPKEKLLIGMPTYGRSFELVNDTQFDIGSPSSGGGKAGKFTNEAGFLSYYEVCSFLAADNTTLVWDSEQQVPFAYRGNQWVGFDDERSLKTKTEWLKEQGFGGIMVWSIDMDDFSGRCGSGKYPLLTALNDELKDYKVELEYDGPYESHGPRGAYTTKDPHDVTCAEEDGHISYHKDWADCTHYYMCEGERKHHMPCPANLVFNPQENVCDWPENVEGCHTPTEAPA", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W2M6-1", "uniprot_id": "Q9W2M6_DROME", "id": "Q9W2M6-1", "name": "chitinase", "aln": "-------------------------------------------------------------------MKLVSIWALAALCLCLGQVAS-SEKL-------------------------------LNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISD-AGEFKSLDTWLDMDD--------------------------GLGFISQTIALKQ--RNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQYSFDGLDLDWEYPGQRGGSEA--DRENFVTLLREIKETYDQYG-------LELGIAVGASEKSASISYDIPAISQHLTFINVMTYDFHMALDGYLGLNAPLPEVAESID----------------YWLSHGAPAEKLILGIGFYGHSYQMSDSSQNWPGAACI-----GPGTAGVYTRENGFLGYHEICLNN------WQTVFDQENGAPYAFQGD-------QWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCG-------------------------------------------------------ESYPLLKTMNRALGREVSGGSGGGGGGGGEGSVTPAPTAAPTSSPTPAPTPGGGSGGNE-----------------------------CAQDGFFVLESDCNKFYQCVGGVRYDFQCGAGLCFNTITLNCDWP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W2M5-1", "uniprot_id": "Q9W2M5_DROME", "id": "Q9W2M5-1", "name": "", "aln": "---------------------------------------------------------------------MGKLLALLAV-LCLSQVIG-AERI-------------------------------VNCYWGTWANYRSGNGKFDVSNIDAGLCTHLSYSFFGIND-NGEIQSLDTWLDYD----------------------------LGFINQAISLKN--QNSNLKVLAVVGGWNEGSTKYSSMSGDWYKRQNFINSALNLLRNHGFDGLDLDWEYPNQRGGNWN--DRANFVTLLREIKEAFAPYG-------YELGIAVGAGESLASASYEIANIAQQVDFINVMTYDFAMASDGQTGFNAPQWAVENAIN----------------FWLSQGAPANKLVLGVGTYGRSFQLSDSSQNWPGAPCR-----GEGSAGSYTGSTGYLGYNEICQNN------WHTVFDYDNAAPYAYSGD-------QWVSFDNVLSVQYKMDFALSKGLAGAMIWSLETDDYRG-QCG-------------------------------------------------------ETYPLLKTINRKLRW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W2M7-1", "uniprot_id": "Q9W2M7_DROME", "id": "Q9W2M7-1", "name": "chitinase", "aln": "---------------------------------------------------------------MWSVSGLVKLLLGVILMAASSSAQGNSSKN-------------------------------VVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIEE-TGQLRVIDAYLDLEE------------------------NSGRGNIKSFNALKL--KNPVLKTLVAVGGWNEGSKRFSLVARDPSKREKFVDDVVRFLQRHGFDGLDLDWEYPGQRHSLDNE-DRSNYITFLKELKEGLEPFG-------FILSAAVGSAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAVVKYWLKAGAPAEKLILGVPFYGRSFTLATAEGNQPGAPHI-----GKGIAGNYSREPGVLGYNELCEMMEREE--WTQKWEATQQVPYAYRQR-------QWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRG-TCGQ------------------------------------------------------QPYPLLHEINRVLFG--------------------GNTPSGLTTESNRESPSEGFSCPA-----------------------------DAPAGYIRDPDNCSKFYYCSGGKTHNFDCPSGLNFDLDTKSCNYSGSVKC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VFR3-1", "uniprot_id": "Q9VFR3_DROME", "id": "Q9VFR3-1", "name": "chitinase", "aln": "-----------------------------------------------------------------MVRYIPLLLLGVLCSWPAATVASDQASR-------------------------------IVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSFIGVNDKSWDVLVIDPELDVDQ----------------------------GGFSKFTQLKK--SNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLDWEYPGATDRGGNYGDKDKFLYFVEELRRAFDREGR-----GWEITMAVPVAKFRLNEGYHVPELCEALDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLN----VNDGLALWEEMGCPANKLVVGVPFYGRTFTLSNSNKNYNMGTYINK-EAGGGAPGPYTNASGFLAYYEICTEVMDKSKGWTVEWDDAGMVPYTYKDT-------QWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFHG-MCGRKNGLTQILYDNMKNYRVPEPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTSAPGPVPTVGSSTPKPTTKKPKKPKKTTTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPEQPMGPQFDPNEIDCTNRDFVPHPNCRKYFRCVHGKPVEFECKEGTAFHTVLNVCDWIENSDRYYCSRMKNKEKGNEAH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9W092-1", "uniprot_id": "CHIT2_DROME", "id": "Q9W092-1", "name": "Probable chitinase 2", "aln": "----------------------------------------------------MTLRSRLSGEAPQLWLLLLLASTASSLWASVAARTGPLHDK------------------------------VVVCYVSTWAVYRPEQGAYAIENFDPNLCTHVVYAFAGLDITQAAIKSLDPWQDLKE------------------------EYGKGGYEKMTGLKR--SHPHLKVSLAIGGWNEGSANYSTLVANNLLRGRFVKQVSSFIRKYNFDGLDLDWEYPTQRKGKPA--DRENFVLLTKELREEFDEHG-------LLLTSAIGASKKVIDEAYDVRQISRYLDYLHIMCYDYHGSWDRRVGYNAPLTAPADDPLS---------VKFSIDYLLKLGAPPEKLVMGLPFYGRTFKTLASGFLNDVSEGV-------GFKGPYTREDGFLGYNEICQTLSNQTSGWTREWDPQTSQVLAKSERNVFTQEINVVTYDSSRSIANKVLFAMSKRLAGVMVWSVDTDDFLGNCKLD-----------------------------------------------------EDTYEDFQKVTAAPK-----------RSSQNYPLLRTINEATMLAVDELAVPEP-----------------------------------QPDDSENEIPHGSIADRKNAGASMVSLGLGVTAVFMLLHRLAQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q06350-1", "uniprot_id": "CHI2_YEAST", "id": "Q06350-1", "name": "Sporulation-specific chitinase 2", "aln": "--------------------------------------------------MVGHSAQHRSKSSLVSHLLILLIFITIIIEMCLYNKIFKNQRSDDIRDNFNNGGHRVPSNVQNHGTHIRDEAFISGVYYSNWSPYKPR--FHFPHDINLKQVSHIYYAFFKINSRTGGIENTDSWSDLEMNLYKSLAIKNSELIKESSNNSVQNILPLGCIGELFYLKNTCSDKKFKVIMSIGGWS-DSENFKIIIKDDKLLQNFVDSSVETMFRLGFDGIDLDWEFPGNNESEPR--GYLKLVRMLRLKLNSLESQIFGKRTEDHFQLSIAAPAFKDKLFYLPITEIDQYVDYWNMMTYDYYGSWSETTGYHSNLFSETELNGNFAMHY----------MIDRFGVNSRKLVLGMAAYGRSFHIKDNKFEPFNQNTVLINKIFKGVGKPTKEIDKADGKEGIWPYKNLPKIGTIEQYDPKYVSAYCFDEKNS-----IFISYDNTKSVKTKAEYVTHNNLGGGFWWESCGEAYAN-----------------------------------------------------------ESRSLINAFNEGLH--------------------------------------------------------------------------------FNVSSKPSIFQDVRVKKYYLNKYGDGGFLSPYLKHLDSRKQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . : :. :*: ::* * ** . .* :* : : *: : . ***::: *::* . : . . : : : : * *: :: * .**::*. **:.: * . : :: : ::. :. * . .* . * : : . ", "identical_positions": 26, "similar_positions": 56, "identity": "2.28%" }, { "cls_id": "homologset.agr.HGNC:17433", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P61023-1", "uniprot_id": "CHP1_RAT", "id": "P61023-1", "name": "Calcineurin B homologous protein 1", "aln": "MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLR----------MMVGVNISDEQL----------GSIADRTIQEADQD-------GDSAIS---------------------FTEFVKVLEKVDVEQKMSIRFLH-------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P61022-1", "uniprot_id": "CHP1_MOUSE", "id": "P61022-1", "name": "Calcineurin B homologous protein 1", "aln": "MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLR----------MMVGVNISDEQL----------GSIADRTIQEADQD-------GDSAIS---------------------FTEFVKVLEKVDVEQKMSIRFLH-------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99653-1", "uniprot_id": "CHP1_HUMAN", "id": "Q99653-1", "name": "Calcineurin B homologous protein 1", "aln": "MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLR----------MMVGVNISDEQL----------GSIADRTIQEADQD-------GDSAIS---------------------FTEFVKVLEKVDVEQKMSIRFLH-------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ABK0L6A7-1", "uniprot_id": "A0ABK0L6A7_RAT", "id": "A0ABK0L6A7-1", "name": "", "aln": "MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGLEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQKNQSLYCQNEGMAQMTGIHGSHKKLRVYILTHKCEGERREERERERERERERGRRRGRGRIRGRRGEERRGEERREEKRREEKRREEKRREEKRREEERAQKRDLEVVKATLPKQRHQLETKFPSTAACGGHFHPNH", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9VNF9-1", "uniprot_id": "Q9VNF9_DROME", "id": "Q9VNF9-1", "name": "", "aln": "MGNKSSLFLRNEEIAQIQEETGFTPNQIERLYSRFTSLDRNDCGTLSREDLMRIPELAINPLCERIVHSFFAESNDDRVNFRQFMNVLAHFRPLRDNKQSK-------LNSREEKLKFAFKMYDLDDDGVISRDELLSILH----------MMVGANISQDQL----------VSIAERTILEADLC-------CQGKIS---------------------FEDFCKALDRTDVDQKMSIRFLN-------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "**.::* :**:**: :*::****: .** **********:.: *******: ********** :**:::**.*. :*:**** **..******:.**::** ****.:**:***::****.* *******. : *.* : *..:* . :. * : . * : : :: ::: . * *. ", "identical_positions": 92, "similar_positions": 56, "identity": "33.45%" }, { "cls_id": "homologset.agr.HGNC:17435", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q99MR3-1", "uniprot_id": "S12A9_MOUSE", "id": "Q99MR3-1", "name": "Solute carrier family 12 member 9", "aln": "-------------------MASESSPLLAYRLLGEEGAAFPP-----NGAGVSGVPS--------------------SRKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADATG---SSGIQVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRNIPLAPRPGTNASSVPHRHGHFTGFNGSTLRDNLGAGYAEDYTTG---AMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIIAVAYTFFIYILLFFLSSFTCDRALLQEDYGFFRDISLWPPLVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSALLTARGGP---SSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGG---SPALSTLFP----PPRAPGSPRALSPQDYVATVADALKMNKNVVLARACGALPPE-RLSRGSSSSAQLHHVDVWPLNLLRPRGGPGYVDVCG-------LFLLQMATILSMVPAWHSAR-LRIFLCLGPREAPG---AAEGRLRALLSQLRIRAEVQEVVWGEGAETGEPE---------------------------------------------------------------------------------------------------------EEEGDFVNGGRGDEEAEALACSANALVRAQQGRGTVGGPGGPEGRDGEEGPTTALTFLYLPRP----------------------------------------------------------------------------PAD-----PARYPRYLALLETLSRDLGPTLLIHGVTPVTCTDL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q66HR0-1", "uniprot_id": "S12A9_RAT", "id": "Q66HR0-1", "name": "Solute carrier family 12 member 9", "aln": "-------------------MASENSPLLAYRLLGEEGAAFPP-----NGAGGSGVAS--------------------ARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYVILALTVLSVCAIATNGAVRGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADVTG---SSGIKVLPQGYGWNLLYGSLLLGLVGGVCALGAGLYARASFLTFLLVSGSLASVLVSFVAVGPRNITLAPRPGTNGSSVPPRHGHFTGFNGSTLKDNLGAGYAEDYTTG---AMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIIAVAYTFFIYILLFFLSSFTCDRALLQGDYGFFRDISLWPPLVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLSALLTARGGP---SSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPAEGTREGG---SPALSTLFP----PPRAPGSPRALSPQDYVATVADALKMNKNVVLARACGALPPE-RLSRGSGSSAQLHHVDVWPLNLLRPRGGPGYVDVCG-------LFLLQMATILSMVPAWHSAR-LRIFLCLGPREAPG---AAEGRLRALLSQLRIRAEVQEVVWGEGAEAGEPE---------------------------------------------------------------------------------------------------------EEEGDFVNGGRGDEEAEALACSANALVRAQQGRGTGGGPGGPEGRDGEEGPTTALTFLYLPRP----------------------------------------------------------------------------PAD-----PARYPRYLALLETLSRDLGPTLLIHGVTPVTCTDL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9BXP2-1", "uniprot_id": "S12A9_HUMAN", "id": "Q9BXP2-1", "name": "Solute carrier family 12 member 9", "aln": "-------------------MASESSPLLAYRLLGEEGVALPA-----NGAGGPGGAS--------------------ARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATG---PSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTG---AVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGP---SSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGS---SPALSTLFP----PPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPE-RLSRGSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCG-------LFLLQMATILGMVPAWHSAR-LRIFLCLGPREAPG---AAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEA--------------------------------------------------------------------------------------------------------EEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGD-AEGPITALTFLYLPRP----------------------------------------------------------------------------PAD-----PARYPRYLALLETLTRDLGPTLLVHGVTPVTCTDL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A2BFP5-1", "uniprot_id": "S12A9_DANRE", "id": "A2BFP5-1", "name": "Solute carrier family 12 member 9", "aln": "-------------------MANEHSPLLVHGVYSMMGNAEDSR----GGSAGTGEASNPKTD---------------PRKLNTFFGVMVPTILSMFSIVLFLRTGFVVGHAGLLHGLLMLFVAYFIISLTILSICAISTNGAVEGGGAYFMISRSLGPEFGGSIGLMFYLAKVCACGVYVLGLVEAIMDVFGQDPGSSV-AQGLRVLPQGYWYTVLYSSVVLLLCMLVCLVGAHIYAKASFLILLVVTVSLISIIISPLIVSPQGFNITHTYGNNHSVTVSPS--YTGFNSTTLKNNLGPRYSLDYSTN---TMMSFATVFAVMFTSCTGIMAGANMSGELKNPSESIPKGTIMAVAYTFTVYVLLYLLLSSTCDRSLLLNDYAVFQRVNVWPPFVTIGVYCASLSAAMCSMIGASRILHALALDQLFGLPLAPAAVTSSSGNPWVSVLYTWALVQCTLFAGQLNVIAGIVTVFYLLAYAAVDLACLALEWASAPNFRPTFQFFSWHTCLLGIISCVVMMFVINPVYSSASIVLLLLLLLFLHYRSPT---SSWGYISQALIFHQVRKYLLMLDSRKDHVKFWRPQVLLMVSNPRSSCQLICFVNQLKKGGLFVLGHVQIGDLDVLPADPVQPQYNFWLSLVDKLGVKAFVDLTLSPSVRQGTQHLLRITGLGGMKPNTLVLGFYDNSYPEDYFLQDPVFCKGDRSEGDNFGVDLPSLQAHFP----PVRHAESPRALQPQEYVSIIQDAIKMGKNICLARYFFQLPPESKGATYMWGKDSMDTIDVWPTNLLTP-GSASYADVGS-------LFLLQMACVLNMASGWRRAR-LRIFVCVESESEDQGWLAKEEQFRELLGKLRIRAAIKIVAWDNVARMVRGP-----------------------------------------------------------------------------------------------------------------NTESQPVSEDFLCAVNGLLKEHS-------------------STAAVRFLYLPDP----------------------------------------------------------------------------PSS-----CELSQQYLTQLDTLTRDLGPTLLIHGVTPVTCTEL", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VJ75-1", "uniprot_id": "Q9VJ75_DROME", "id": "Q9VJ75-1", "name": "Solute carrier family 12 member 9", "aln": "----------------MSASAEQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFG--PRGHF-VSGDSHLPDGDWWRFLTSSMINTLQLLVCLVGAALFAKTSVIILATVTVCLFATYFSFLFVGATNNTIP-VPGDNILSNTTTFLDYTGLNATTLRDNLGSHYGRDYTSNG--KQVDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEALSKDQVFGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVDFVNDLKKSGLYIIGHVKLGDFKGIEDAEDNQQ---WWSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSPYKTDDFN---------NGEIQNF----PIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDKN-----FISMSKHVKYIDVWPINIFNPTSGDP-FDMVS-------LFMMQLAVIM--LAKWKHLR-VRIFLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRD-----------------------------------------------------------------------------------------------------TDFSRHARTLKQFTAQADNVVLEDDDEVGEETLNRSLLYMQRANQIIRERSDQTALSFIYLAAP----------------------------------------------------------------------------PKLSAPDFAQRSASYMELLTELTADLPPTILVHGVSTVTSTTL", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P38329-1", "uniprot_id": "VHC1_YEAST", "id": "P38329-1", "name": "Vacuolar cation-chloride cotransporter 1", "aln": "MVSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPN------------------KDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSP---------------FTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHS------PLYSLIFTWILTQLCLFS-DVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVDGISASVLFLAMILLFLFIHYFSPP---KSWGDVSQSLIYHQVRKYLLRLR--QDNIKYWRPQILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQKQVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIP----NKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEWKRTHSLRVILFVEQEYHRT---NETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :.: :. : . . : . .*.*: **. *. *.::* ::*:* *:::*: *: : ::::* * :* *:.**:***::.***.*:****:** *.***** :*::.:* ..: * * :: :* . ** * . .::: * *. :*: :::. : : :: .: : .* : .. :** . *:::** . . : . * *.*:* . :**:***.**.**:.**.:** **: .: :** * :: : . : : : .: :. . :* ::: : : .::*:: :*.*:: *::: . * :: :* *.: *: ..* :* . :: ::::: . :*:*: : :.****** *. *. :* :* :: *:::. :. :: :* : . . .** :**:*::******** * ::::*:****:**:*..** . *: : *.***.**:::*** : : * * .: * :***.:: . *: * :::: :*:*.**** ::**:* ...: . : . * . .. *::* : * * .*: :.: * . :*::* :: . :::*:* :: . *: : :*::: :: ::: : : :: . : : . :: :. * * *: * .* * :*::. : .. * *", "identical_positions": 174, "similar_positions": 280, "identity": "14.85%" }, { "cls_id": "homologset.agr.HGNC:17438", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ABK0LVH9-1", "uniprot_id": "A0ABK0LVH9_RAT", "id": "A0ABK0LVH9-1", "name": "", "aln": "MQFQRAESAGTSSADAHRGNKRTTKEGFSDLRFQNVSLLKNRSWPRLSSAKGPCRAVLEPLPDHRRNLAVIPDGEKCSSNNDYEDPELQLLRAWPSMKILPARPIQESEYADTRYFKDAMEAPLLLPPKPSVSTERQIRDVGMNPQKEDVDKPTSKNVRSQHFKGFKYTKVNKTPLPPPRPAMTLPKKYQPLPPAPPEESSEHSPPKHTFPEAQRGPRQRSSKDFSKVLEAEEESHHQTKPESPCPSPSLNTQKSPPAIASSSYMPGKHNKQARDHTGIMQHCPPQRCQAAASHSP--PVLSYENTNSEKPVPTKFDEKDAQQNEWYIGDYSRQAVEEVLMRESKDGTFLVRDCSTKSKAEPYVLVVFYGNKVYNVKIRFLESNQQFALGTGLRGNEMFDSVEDIIEHHMYFPIVLIDGKDK-AAHREQCYLTQPLPLARHLLTQYSNQTLHEEEDQWEEQEPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9QZE2-1", "uniprot_id": "CLNK_MOUSE", "id": "Q9QZE2-1", "name": "Cytokine-dependent hematopoietic cell linker", "aln": "MTSQ--------------GNKRTTKEGFGDLRFQNVSLLKNRSWPSLSSAKGRCRAVLEPLPDHRRNLAGVPGGEKCNSNNDYEDPEFQLLKAWPSMKILPARPIQESEYADTRYFQDTMEAPLLLPPKASVSTERQTRDVRMT-HLEEVDKPTFKDVRSQRFKGFKYTKINKTPLPPPRPAITLPKKYQPLPPAPPEESSAYFAPKPTFPEVQRGPRQRSAKDFSRVLGAEEESHHQTKPESSCPSSNQNTQKSPPAIASSSYMPGKHSIQARDHTGSMQHCPAQRCQAAASHSP--RMLPYENTNSEKPDPTKPDEKDVWQNEWYIGEYSRQAVEDVLMKENKDGTFLVRDCSTKSKAEPYVLVVFYGNKVYNVKIRFLESNQQFALGTGLRGNEMFDSVEDIIEHYTYFPILLIDGKDK-AARRKQCYLTQPLPLARLLLTQYSSQALHE-----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q7Z7G1-1", "uniprot_id": "CLNK_HUMAN", "id": "Q7Z7G1-1", "name": "Cytokine-dependent hematopoietic cell linker", "aln": "MNRQ--------------GNRKTTKEGSNDLKFQNFSLPKNRSWPRINSATGQYQRMNKPLLDWERNFAAVLDGAKGHSDDDYDDPELRMEETWQSIKILPARPIKESEYADTHYFKVAMDTPLPLDTRTSISIGQPTWNTQTR--LERVDKPISKDVRSQNIKGDASVRKNKIPLPPPRPLITLPKKYQPLPPEP-ESSRPPLSQRHTFPEVQRMPSQISLRDLSEVLEAEKVPHNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQPCSPQRCQPPASCSPHENILPYKYTSWRPPFPKRSDRKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLVRDCSTKSKEEPYVLAVFYENKVYNVKIRFLERNQQFALGTGLRGDEKFDSVEDIIEHYKNFPIILIDGKDKTGVHRKQCHLTQPLPLTRHLLPL-------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VAA1-1", "uniprot_id": "Q9VAA1_DROME", "id": "Q9VAA1-1", "name": "SH2 domain-containing protein", "aln": "--------------------------------------------------------------------------MCCWCARVY----------WTVLHNLLARMMDS-----------------------------------------------LMEVRSPTFCSCCFG-------------------------------------------YQRQASQEG--DVAERVSSTDDDPQQQPREDYVIVDDADVN-----------------------------------------------------------YAEIEERHVEKEQYYF--TVDRPTAERMLHGREDGSCLVRPFKAADQWIRYIVSIWAADQYYHLFIRQVDRRQRYAIGQKKSQERCFGSPSEIVEFYTEHPLLCTN------KVRSQCVQLRPISYA-------------------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . * * :: * ** :.. :*** : . ** . * . *.:. : : . :* *. . :.: . :.:.. ::::*: :.. : ::: :**: *** .: .: *:: :: :: *:: ** :: .*::*:* :. *.* .:*:*.: .*:: : *.** :*:. : ", "identical_positions": 36, "similar_positions": 78, "identity": "7.76%" }, { "cls_id": "homologset.agr.HGNC:1744", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3ZRK7-1", "uniprot_id": "D3ZRK7_RAT", "id": "D3ZRK7-1", "name": "Cell division control protein", "aln": "---------------------MPQTRSQTQATIDFPKKKQSKTLSKT------------------------------------NSRDSEVKLRNVQPVPTTPCADIKILPLSPRKRLGDDNLCNTPHLSPCSPPKLGRKENGPPRSHTRKGC------------RLIFDDEL------------------------AVKASAPKEQDRVPQHQILSS-AQRGQESETNPEQKCPPEKESACMRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRDFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKTIVLNCMSLRNAQAVFPAIAQEIGREELCRPTGKDLMRKLEKHLTAERGPMIVLVLDEMDQLDSKGQ------DVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEAREGCKPKLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRS---------QTVLKPLSECKSPCESLVPKRVGLAHISQVISGVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTKRLKIKEVTLGKLYEAYSSVCRKQQ-VAAVDQSECLSLSGLLESRGIVGLKKNKES-RLTKVSLKIEEKEIEHVLKGKAFIGNILAAGLP---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "O89033-1", "uniprot_id": "CDC6_MOUSE", "id": "O89033-1", "name": "DNA replication factor CDC6", "aln": "---------------------MPQTRSQTQATIGFPKKKLSNTLKKP------------------------------------NSRDCEVKLRNVQPVPTTPCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGC------------RLVFDDEP------------------------TFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAEKGPMIVLVLDEMDQLDSKGQ------DVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRS---------QTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQ-VTAVDQSECLSLSGLLESRGLVGLKKNKES-RLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q99741-1", "uniprot_id": "CDC6_HUMAN", "id": "Q99741-1", "name": "DNA replication factor CDC6", "aln": "---------------------MPQTRSQAQATISFPKRKLSRALNKAK-----------------------------------NSSDAKLEPTNVQTVTCSP--RVKALPLSPRKRLGDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGR------------RLVFDNQL------------------------TIKSPSKRELAKVHQNKILSS-VRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMDVIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTAQAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQ------DVLYTLFEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLNQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKS---------QTILKPLSECKSPSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVCRKQQ-VAAVDQSECLSLSGLLEARGILGLKRNKET-RLTKVFFKIEEKEIEHALKDKALIGNILATGLP---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VSM9-1", "uniprot_id": "Q9VSM9_DROME", "id": "Q9VSM9-1", "name": "Cell division control protein", "aln": "MAAVRRSTRLSSISKATAASPLPPSTQTPRRSEVWKRRQPKKVLADSDEEEEVVTAIYDLTSPVSENNENRNVLNKMDKISRRRTSQVQVAQSELPKTPRSTKKTVQSAGSSRAKREEENREATARFLEGEQDSEVDPLHGSPPKQRKLQPLPQHLISPSRLLDRLSIDERQEEEVEATTHKTETAEQQPKHQAKDEAKPRPKQQEDPLAQKQQEKPPTKQPNKNQTKEKSNIQTNEETQQNNLPSPSRNKYQNARRVLNSAETQNLPGRESQLQELREFFSNHLESQTSGSLYVSGQPGTGKTACLSLLLRDPDFSKR-LQRVYINCTSIASVGAVYKKLCTELQLKVSGR-TERDHLEAIQRHLKTAKR-MLLLVLDEIDQLCTSRQ------EVLYTIFEWPALPGSRILLVGIANSLDLTDRALMRLNARCELKPRLMHFPPYSKQQIVEIFKSRLAEAEVLDVFPPVTLQLLAAKVSAISGDVRRALDIGRRVVEIAEQQKRDGEKEFN-MKALQLEGKDAVEAKEKQDTLKPVQVTQVAAVLNKVYGASQNLEED-IEASFPLQQKLMLCTLVLMLRNERNKDISMGRLHEVYRRVCAKRN-ILALDQAEFTGTVDLVETRGILRIMRKKEP-RLHKVLLQWDEEEVHAALSDKQLIASILSDTACLSK", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P09119-1", "uniprot_id": "CDC6_YEAST", "id": "P09119-1", "name": "DNA replication factor CDC6", "aln": "---------------------------------------------------------------------------------------------------------MSAIPITPTKRIRRNLFDDAPATPP-----------RPLKRKKLQFT------------DVTPESSP-------------------------EKLQFGSQSIFLRTKALLQKSSELVNLNSSDGALPARTAEYEQVMNFLAKAISEHRSDSLYI-TGPPGTGKTAQLDMIIRQKFQSLPLSLSTPRSKDVLRHTNPNLQNLSWFELPD--GRLESVAVTSINCISLGEPSSIFQKIFDSFQDLNGPTLQIKNMQHLQKFLEPYHKKTTFVVVLDEMDRLLHANTSETQSVRTILELFLLAKLPTVSFVLIGMANSLDMKDRFLSRLNLDRGLLPQTIVFQPYTAEQMYEIVIQKMSSLP-TIIFQPMAIKFAAKKCAGNTGDLRKLFDVLRGSIEIYELEKRFLLSPTRGSLNSAQVPLTPTTSPVKKSYPEPQGKIGLNYIAKVFSKFVNNNSTRTRIAKLNIQQKLILCTIIQSLKLN--SDATIDESFDHYIKAITKTDTLAPLQRNEFLEICTILETCGLVSIKKTKCKGKTKRFVDKIDVDLDMREFYDEMTKISILKPFLH---", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. : ** : : * : :. : : :. * : : : . . :. : .: . ::. : :. . : :: :.* : ... * : .... * * . . :** *: ::: : .: :: . : : :::****:*:* .: :* . *. ::*:*:**:**:.** * **: *: : * **: :*: *. .:: . :: :::: * * :. :**:*: :*: * :** * : : : : : : : . . . . .: :***:::*::: : .: ::.. .: * * : : .::: * ::*: *:: : :.* : :. : : . : .: .** ", "identical_positions": 58, "similar_positions": 154, "identity": "8.59%" }, { "cls_id": "homologset.agr.HGNC:17440", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0A096UWG1-1", "uniprot_id": "A0A096UWG1_RAT", "id": "A0A096UWG1-1", "name": "E3 ubiquitin-protein ligase COP1", "aln": "MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAASAATLVSGGVAPAAGSGGLGGPGRPVLVAAAVSGSASAGGAVSAGLSRLSCAARPSAGVGGSSSSLGSSSRKRPLIAPLCNGLLNSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDLLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGPSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYGTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKVLELV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9R1A8-1", "uniprot_id": "COP1_MOUSE", "id": "Q9R1A8-1", "name": "E3 ubiquitin-protein ligase COP1", "aln": "MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAASAATLVSGGVAPAAGSGGLGGPGRPVLVAAAVSGSASAGGAVSAGQSRLSCAARPSAGVGGSSSSLGSSSRKRPLLVPLCNGLLNSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDLLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGTSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYGTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKVLELV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8NHY2-1", "uniprot_id": "COP1_HUMAN", "id": "Q8NHY2-1", "name": "E3 ubiquitin-protein ligase COP1", "aln": "MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSG--SGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****************************************.***:******* ********** ******.**** *.*****:* ** *******************.******:.******:**************************************************************************************************** ******************************************************************************************************************.**************************************************************************************************************.*****************************************************************************************************************************************************************************************************************************************************************.**********************", "identical_positions": 714, "similar_positions": 12, "identity": "97.41%" }, { "cls_id": "homologset.agr.HGNC:17441", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "M0R3J8-1", "uniprot_id": "M0R3J8_RAT", "id": "M0R3J8-1", "name": "", "aln": "MPAMVEKGPEVSGKRRGRNTASAAASAAAASAASAAASA-----AASAGTASASAAATASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEPNGS-----------------------------------------------------NPVDIDIDPNRESKKEVPPTETVPQVKKEKHSTQAKNRAKRKP-------------PKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNMKQTN-------SALKEKLAGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVN-YRRRFSIDEVLQEWEAEHGKEEANGPTNQKPAKSPESSVKIQEEEDEAASVLDVRYASAS--------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CFE3-1", "uniprot_id": "RCOR1_MOUSE", "id": "Q8CFE3-1", "name": "REST corepressor 1", "aln": "MPAMVEKGPEVSGKRRGRNTAASAAS-AAASAASAAASA-----AASAGTASASAAAAASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEETNGS-----------------------------------------------------NPVDIEIDPNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKP-------------PKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNIKQTN-------SALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVN-YRRRFNIDEVLQEWEAEHGKDETNGPANQKPVKSPESSIKIPEEEDEAASVLDVRYASAS--------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9UKL0-1", "uniprot_id": "RCOR1_HUMAN", "id": "Q9UKL0-1", "name": "REST corepressor 1", "aln": "MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGN-----------------------------------------------------NPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKP-------------PKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTN-------SALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVN-YRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAP-VLDVRYASAS--------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q59E36-2", "uniprot_id": "RCOR_DROME", "id": "Q59E36-2", "name": "REST corepressor", "aln": "--MVLAERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASL-----------VGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVP-EAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPELAAAVLKIGVAEAADAVATVASSTASGVIGAATSASKPSTSATITIIDESDTATNSSSDVVTTGLATSTGSSALSSTTSAPASKTQTSSEELSAQKSNPASGIAAIGAATGGGQTANSSGSKRDSSVLPVAEQPPAKKIALSTGGGSSVAEFLAN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :: : .. *.**.. ..:.. ::...: :*. ..:. : *. * .*: ..::..*.. .*..:. : .. *.:.:.. :*** :***. * : * : **.:: :: .:*****.:.:.: **:***::****:*** ************::*::: **.**********:**********.****:****:*************:******** ::*.***: : * ::..:: .* ... : ::: : :* *:.*. .* .*.* * . :*: .: .:: **.* *:.*:*. : .* : **:. .:::*.* :* : . : : : :*. * . . : * :.. .: . :. : . . . * * :. *.. ...:. . *: .* :: ::.:.. : . *::. ", "identical_positions": 136, "similar_positions": 182, "identity": "22.52%" }, { "cls_id": "homologset.agr.HGNC:17442", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9D267-1", "uniprot_id": "LCN9_MOUSE", "id": "Q9D267-1", "name": "Epididymal-specific lipocalin-9", "aln": "-MVLLLVLGLVLSLATAQFN----LHTAVRRDYNLARISGTWYLDSIASDNMTRIEENGDLRLFIRNIKLLNNGSLQFDFHFMLQGECVAVTMVCEKTKNNGEFSVAYEGKNKVLLLETDYSMYIIFYMQNIKNGTKTQVLALYGRSILLDKTHQREFENICNLYGLDSQNIIDMTKKDFCFL-----------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6GET9-1", "uniprot_id": "A0A8I6GET9_RAT", "id": "A0A8I6GET9-1", "name": "", "aln": "-MLQYQGRRRRGSKADSHQASYGVLCSSHSRVVMQMKISGVWHLVSMASDNMTYIEEKGDLRLFIRNIQFLNNSNLQFDFHIMIHGECVAVTVVCEKTKNSGEFSIAYEGENKVLLVETDYTMYAIFHMQNIKNGTRTQVLALYGRFMQIDETYQERFENICKLYGLGSQNIIDMTNKGRVPFSDAERPGEGSLPPGVACTGALRIAVGGQGGARQAI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8WX39-1", "uniprot_id": "LCN9_HUMAN", "id": "Q8WX39-1", "name": "Epididymal-specific lipocalin-9", "aln": "MALLLLSLGLSLIAAQEFDP-----HTVMQRNYNVARVSGVWYSIFMASDDLNRIKENGDLRVFVRNIEHLKNGSLIFDFEYMVQGECVAVVVVCEKTEKNGEYSINYEGQNTVAVSETDYRLFITFHLQNFRNGTETHTLALY---------------ETCEKYGLGSQNIIDLTNKDPCYSKHYRSP---PRPP-------MRW------------", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * : * ::**.*: :***::. *:*:****:*:***: *:*..* ***. *::******.:*****::.**:*: ***:*.* : **** :: *::**::***.*:.**** : *: ***.******:*:*. ", "identical_positions": 71, "similar_positions": 46, "identity": "32.57%" }, { "cls_id": "homologset.agr.HGNC:17443", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q91YM4-1", "uniprot_id": "FAKD4_MOUSE", "id": "Q91YM4-1", "name": "FAST kinase domain-containing protein 4", "aln": "MAVRLMKRCTCLLREATRLVPTVAPVGRLRLAGVSCKTLTS-SVSSPSS---GSLAELLGKEQVFTPYPEHQELDFLIEKASRPEQLLELLGSDHSLHHNHAALILIRLSYLLSEKPKEKALLAEDARFQRLVKLVDSQITCVWHGTLVKLLRSLYTLVLPQISKELQSVEQEVRWRLRRLKYKHLVFLAESCASFMKEQHSQELLA-ELLMHLERRWTEINDSRTLVTMMTMAGHLSESLMNHLEDKCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKP-FPMTKGMLLDLAYAYGKLSFHQTQVSQRLAADLLPFIPS--MTPGEVARCAKSFAFLKWLNLPLFEAFTQHLLSRVQDVSLSHVCSVLLAFARLNFHPEQEEDQFFSMVHEKLDPVLGSLEPALQVDLVWALCVLQHVHETELHTVLHPGLHARFLESKSP-KDQSTFQKLVHINTTALLEHPEYKGPFLPASAVAP--IPSPSNKKMTPLQKELQETLKALLGNTDKG-SLEVATQYGWVLDAEVLLDADGHFLPLRNFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNFNS-RSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKSAYLKDKMRKAMAEELAK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5M9G9-1", "uniprot_id": "FAKD4_RAT", "id": "Q5M9G9-1", "name": "FAST kinase domain-containing protein 4", "aln": "MAVRLMKQCTCLLREATRLVPTVAPVGRLRLAGVACKTLTS-SVSSPSS---GSLTELLGKEQVFTPYPEHQEVDYLIEKATRPEELLELLGGDHSLHHNHAALILIRLSYLLSEKPKEKALLVEDARFQQLVRLVDSQITSVWHGTLVKLLRSLYTLVLPQGSKELRSVEQEVRWRLRRLKYKHLVFLAESCAPFMKEQHSKELLA-ELLRHLERRWTEISDSRTLVSMMTMAGHLSESLMNRLEDKCLELVEQFGPDELRKVLMTLAAQSRRSVPLLRAISYHLVQKP-FPMTKGMLLDLAYAYGKLSFHQTQVAQRLAADLLPFIPS--MTPGEVARCAKSFAFLKWLNLPLFEAFTQHLLNSAQDVSLSHLCSVLLAFARLNFHPEQE-DQFFNLVHEKLDSVLGSLEPALQVDLVWALCVLQQVQVAELQTVLHPGLHTRFLESKSP-KDQSTFQKLVHINSTALLEYPEYKGPFLPASAVAP--SPSPSNKKMTPLQKELQDALKALLGNNDTG-SLEVATQYGWVLDAEVLLDAEGHFLPLRDFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNFNS-RSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKTAYLKDKMRKAVAEELAK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q969Z0-1", "uniprot_id": "FAKD4_HUMAN", "id": "Q969Z0-1", "name": "FAST kinase domain-containing protein 4", "aln": "MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTS-SATSPISHLPGSLMEPVEKERASTPYIEKQ-VDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLA-ELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKP-FSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPS--LTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQE-DQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQ-KDQNTFQKLLHINATALLEYPEYSGPLLPASAVAP--GPSALDRKVTPLQKELQETLKGLLGSADKG-SLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNS-RSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "E7F3K7-1", "uniprot_id": "E7F3K7_DANRE", "id": "E7F3K7-1", "name": "FAST kinase domain-containing protein 4", "aln": "MTTRLLCRWARWFPRSPRTATASARLQTSTVHHTEPLCLMTLSWIRPSVRHLCQGNELAKIDEGTVPY-ERTKLIKLVEKASTPDEVLQLWD-QHGGTGSEAARCLIQLNLRVVEKGSKG--VLLDPRCKSMQDTLNTQLSTVWNGSLVGLLRTLTMLGLPAHAPLLGAIQNEVLWRIRRLSYRHLSYLADWVAFQRKMGYENEVLTSTLLKQLELRWTELSDSRTITILMGRASLFTPSLMDKLEDKALELAESFTAEDMRRVALALASQNRRAVPLLRALSYHLNQKPSFELKTPLLLDIAYVYGKLNFSQTQFFKRLASELLPRLSE--LSSSEVSRCAKSLALLKWLHLPLFEGFAQHYVSNSEKYSTLQMCNLLMAFAKLNFQLGKE--QFYLKVHKALEDSFTSLEPFLKTDLVWSLCVLNQANSDYISSVIKPDFQKKLSAGGIEGRTENYRQKLLNICAYAQLEP---LGLAVDASAVLLPDRQSKAESSTSALQKTLHTALWSLANERKQALHTAVKTLYGWTIDGELVVDSENKPIDMENFKAPHLPEGGGADALPEGTRRIAFVAWDFSNFCL-KSKDLLGRFAMQKRHLQLAGFIVVEVPYFEFLELKSDWQKVAYLKDKLGKAVAEEMAK", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VD14-1", "uniprot_id": "Q9VD14_DROME", "id": "Q9VD14-1", "name": "RAP domain-containing protein", "aln": "-MLGLQRFAGSFVTQLYRRAAFSSSVR-------------------------AAGIPVAPTGAQSDAVEPEARAPAVEEAAKKPRGHMVAAAFESLRNDDPKDESKSQASSKIDER-------IINAKTVNGLLTITENNNGFSRKHALRIVSILAEWSTLNRVKISEFENDTRFLRICRMLGRTVPKNNNANNKDLGDNGTAKRIS-------GFRTDDLN------TVLGVAG----------DDEAAKLIASISLPQMVKVMSTLAQRKRRSTPLLRSLAFNISSAS-ESLDLKQAGDVLFAMSTLNFQDSVLGAKVCADVQSALPKNVEKSAVVGSIITSLGILRYRDLDILESLTQWLLKNSEICRPQDLSAYFLTSALLNFKSAQLEEVSKKLVKSIVREDFTKQSEWLS--FVWSLTMLGLVEHGHLASVLSADFLETLKKDKAG-VTATSKMRLLNLNSYAQLIATDYKGPLLPTDSPVY-QVPMAHPKAKQVLVNGMLDALKSLLPASNHL-QTAVDTKMGFLIDALCHFDANKNPLPLD--------------KENPNAIRVALMVIDFHDICHGTHRSGSGVTNLTFDLLEKSGYHVIPVPYNEFSTSDKLLKRVQYLESKFKAIASSK---", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . . * .. : : . . : : *. * : . . : . : *: :.: : : . . :: * :: *: :: : : : : :: * ::. :: .. :*:. :* : :: :* ** :.**:.****:::::: . . : *: :. ..*.* :: . ::.::: . :.. ... *. .*:.:*:: * ::*.::* :. : .:. ::: * ***: : *:. : : . *. :**:* :* .. : :*: . : : . . :*::: : * * * : :.: * : : :* .* . * * *: :*. .*:: . : : .: *:*:: :* :: :. * : : :*: :: **: *: .. :: **:.*: :.: ", "identical_positions": 62, "similar_positions": 181, "identity": "9.64%" }, { "cls_id": "homologset.agr.HGNC:17447", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6Q0N0-1", "uniprot_id": "CSTN1_RAT", "id": "Q6Q0N0-1", "name": "Calsyntenin-1", "aln": "----MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAG----------EICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPG-TGALAVFPSIHLETCDEPVAS-----VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLD--PKEPFTISVWMRHGPFGRK----KETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKK--YRPAEFHWKLNQVCDEDWHHFVLNVEVPS-VTLYVDGVSHEP--------FSVTEDYPLHPTK-IETQLVVGACWQ-------------------GGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNR------GVQIQTSSSQAVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVE--------PEADGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNH--SDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEE----------------EEDITSAESESSE--EEEGGPGDGQNTTRQQQLEWDYSTLSY-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9EPL2-1", "uniprot_id": "CSTN1_MOUSE", "id": "Q9EPL2-1", "name": "Calsyntenin-1", "aln": "----MLRRPAPALAPAVRLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQHSSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPG-TGALAVFPSIHLETCDEPVAS-----VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLD--PKEPFTISVWMRHGPFGRK----KETILCSSDKTDMNRHHYSLYVHGCRLVFLLRQDPSEEKK--YRPAEFHWKLNQVCDEDWHHFVLNVEVPS-VTLYVDGIPHEP--------FSVTEDYPLHPTK-IETQLVVGACWQEYSGVESGNETEPATMASAGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDANR------GVQIQASSSQAVLTLEGDNVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESAEGISLFPELRIISTITREVE--------PEADGSEDPTVQESLVSEEIVHDLDTCEVTVEGDELNAEQESLEVDVTRLQQKGIEASH--SDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEE----------------EEDITSAESESSE--EEEGGPGDGQNATR--QLEWDDSTLSY-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O94985-1", "uniprot_id": "CSTN1_HUMAN", "id": "O94985-1", "name": "Calsyntenin-1", "aln": "----MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPG-TGALAVFPNIHLETCDEPVAS-----VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVS--PKEPFTISVWMRHGPFGRK----KETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKK--YRPAEFHWKLNQVCDEEWHHYVLNVEFPS-VTLYVDGTSHEP--------FSVTEDYPLHPSK-IETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGR------GVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVE--------PEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSS--SELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEE----------------EDDITSAESESSE--EEEGEQGDPQNATRQQQLEWDDSTLSY-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "F1R520-1", "uniprot_id": "CSTN1_DANRE", "id": "F1R520-1", "name": "Calsyntenin-1", "aln": "----MRIRGVKPFASAVGLLLG-LLY--AVDAAKVNKHKPWIETTYHGIVTENDDKVLLDPPLIALDKDAPLRYAG----------EICGFRIHGQNVPFEAVVLDKSTGEGVIRAKDKLDCELQKEHTFTIQAYDCGEGPDGGNMKKSHKATVHIQVNDVNEYSPVFKEKSYKATVIEGKKYDSIMKVEAVDADCSFQFSQICSYEIVTPDVPFTIDKDGNIKNTEKLNYGKERMYKLTVTAYDCGKNRASEDVLVKINIKPTCKPSWQGFNKRIEYEPG-TGSLALFPSMHLETCEEPITS-----IQASIMLETNHIGKGCDRDTYSEKSLHKLCGASSGTVELLPAPSNSANWTVGLPTDNGHDSDQVFEFNGTQAIKVPEGVVSTT--LKEPFTISVWMRHGPGGRE----KETILCNSDKTEMNRHHYSLYVHNCRLVLLLRQEPTESES--YKPAEFHWKLDQVCDKEWHHYVLNIEFPA-VTLFVDGGTFEP--------FLVTEDYPLHTSK-IETQLTIGACWQ-------------------GGSARMTQFFRGNLAGLMIRSGKLENKKVIDCLYTCKEGLDVQLPEEVAS------AVKVEFNPNQSSLSLEGDDIESFEKVMQHISYLNSRQFPTPGIRHLRVSTTVKCFNEETCISVPDSEGYVMVLQPEEPKISLSGIDHFARGAAEFESVEGVTLFPELRIVSTITREVEVEAEAE--TEAEGEDDPTVQETVVSEEIMHNLDTCEVTVVGEDLNGDHESLEVDLAQIQQRALEMSS--SNVGMVITGVNTMANYEQVLHLIRYRNWHTEALFDRKFKLVCSELNGRYISNEFKVEVNVIHTANPMDHANNAMVQPQFISQVQHASVDLSGHNLVNTHQASVVPSAATIVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQENGKENEMDWDDSALTITVNPMETYEDQHSSEEEGDEEEEE-SEDGEE----------------EDDITSAESDSSE--DEAGEQEDQQGSSRQQQLEWDDSTLTY-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V498-1", "uniprot_id": "CSTN1_DROME", "id": "Q9V498-1", "name": "Calsyntenin-1", "aln": "MTFHKTFGYGCIVLICFELLFAGVETSSENDDEYLTQKEIILEKSYHGLIRENETLVEITP-LIKVNEE-----------------KICNFHILKKPYHEIPFKIELVNNLGILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMK-ESAPIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLP---HGAEWTKELSYDEGLEP--IFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQS-------------------LENRLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCKNES-SLRLPPIETYIMVNEPIAP---LGIDIDVVSASLETSDLTPPSYSPKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKNNGKLEEKNHIDSCSVVVFP-SLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPS----SLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIARLKNNQKYIEHHQPCPKISDDGLIWDDSALTITINPMQADVTSDASSESENSESEDEEALKDGFTHINQLEWDNSNIFQQ", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . **:. : :.::: :* :***:: **: * : * ** :::: :**.*:* : .. :: .. *::::: .*:** :*.: * * * *. * *:.*.*** * *****:*.* * ** * **: :..*::*** * **: *.::*.***:. * **::*::* ***** *.: .: : *:*.****. : : ::*.*.:: .* . : * .**:* .* * :* :**. :*: *: . . ::::: *:*.**. ***** . * :. . :*** . :** *. *:* :. :*.*:*: .: :* *: .:**:* . :**.. . ** *:*.:*. .***** :*:*:.***::*:*:: .* . : ***::**: :***::***:***:* .: * *::** .* * :*:***.:: ::*.*.:***:* . ::.: *.*::: : : ..: : *.* ** * * : ::: . : :...: .::: *:::.*:*::* ** * *.:.: :*::* ** .: :* : *:** :* * *. ... .: * .. *:: * .* .: *. : :*.:. . * :.:*:*.*.* .** ::*.:::* . . .:: . .. *: : * :*::.* :**: : * * :. ::* *** *:: ..:* *.*:.: :.*:*. :.: ::.: . : :. :.:: : . * . . . . : :: . .: :* ::: .: *.. * :: ::* . : ..::: *..: .: .:: : *:** *..** :. . :. :: ***** *.: ", "identical_positions": 243, "similar_positions": 354, "identity": "23.28%" }, { "cls_id": "homologset.agr.HGNC:17448", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VDA1-1", "uniprot_id": "CSTN2_RAT", "id": "Q8VDA1-1", "name": "Calsyntenin-2", "aln": "----MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPTIVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPQEAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQRQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPG-SGSMPLFPGIHLETCDGAVS-----SLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKIPDGIVPKN--LTDQFTITMWMKHGPSPGV-RAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADT--FRPAEFHWKLDQICDKEWHYYVINVEFP-VVTLYMDGATYEP--------YLVTNDWPIHPSH-IAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEG------LDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINQALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQ-------ITLQGTERFWRPAAQFESARG-----VTLFPDIKIISTFAKTEASGDLRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATN--STAGYSIYGVGSMSRYEQVLHHLRYRNWHPTSLETRRFQIKCSELNGRYTSNEFNLEVSVLHEVRVSDTEHVNHLIVQPPFLQSVYHPETRSSIQ--RSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAK-EAEMDWDDSALTITVNPMEKHEGPGHGEDE-TEGEEEEEAEE-------------------GMSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQRPERSTWNTAGVINIWK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ER65-1", "uniprot_id": "CSTN2_MOUSE", "id": "Q9ER65-1", "name": "Calsyntenin-2", "aln": "----MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLVAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPG-SGSMPLFPSIHLETCDGAVS-----SLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKIPDGIVPKN--LTDQFTITMWMKHGPSPGV-RAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADT--FRPAEFHWKLDQICDKEWHYYVINVEFP-VVTLYMDGATYEP--------YLVTNDWPIHPSH-IAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEG------LDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQ-------ITLQGTERFWRPAAQFESARG-----VTLFPDIKIVSTFAKTEASGDMRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATN--STAGYSIYGVGSMNRYEQVLHHLRYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVRVSDKEHVNHLIVQPPFLQSVHHPETRSSIQ--RSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAK-EAEMDWDDSALTITVNPMEKHEGPGNGEDETTEVEEEEEAEE-------------------GSSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQSPERSTWNTAGVINIWK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H4D0-1", "uniprot_id": "CSTN2_HUMAN", "id": "Q9H4D0-1", "name": "Calsyntenin-2", "aln": "----MLPGRLCWVPLLLALGVGSG--SGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPG-SGSMPLFPSIHLETCDGAVS-----SLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKVPDGIVPKN--LTDQFTITMWMKHGPSPGV-RAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADT--FRPAEFHWKLDQICDKEWHYYVINVEFP-VVTLYMDGATYEP--------YLVTNDWPIHPSH-IAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQACKEG------LDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPR-------ITLRGTDHFWRPAAQFESARG-----VTLFPDIKIVSTFAKTEAPGDVKTT--DPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSELHQRHLDATN--STAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQ--HSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAK-ESEMDWDDSALTITVNPMEKHEGPGHGEDE-TEGEEEEEAEE-------------------EMSSSSGSDDSEEEEEEEGMGRGRHGQNG---ARQAQLEWDDSTLPY---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0S5G3-1", "uniprot_id": "CSTN2_DANRE", "id": "B0S5G3-1", "name": "Calsyntenin-2", "aln": "-----MKMRAITAMLLLVLSGQCG-------------ILAGKVNKHKPWIETSYHGVITENMDTVMLDPPLVALDKDAPVPYAGEICAFKIHGQEAPFEAEVLNRTSGEGVLRARGPIDCEQQKEYTFIIQAYDCGASPNGADWKKSHKAVVHIQVDDVNEFSPVFREPLYRATVTEGKIYDSILQVEAWDQDCSPQYSQICNYEIVTQDTPFAIDRNGNIRNTERLSFDKQQHYKIMVTAYDCGQKRAMESVPVHIDVKPVCKPGWQGWNKRVDYEPG-TGSKQLFPKMHLETCDGPLS-----SVRAMVELQTSHIGKGCDRETYSEKSLQKLCGAASGSTDLLPAPSTSTNWTASLLTDSGRDSDLIFRFDGRQAANIPDWVVPQN--LTDQFTIATWMKHGPSPGL-RAEKETLLCNSDKTEMNRHHYSLYVHNCRLVFLLRRDFIQLDS--FRPAEFHWRLEQICDKEWHYYVINVEFP-SVTLFVDGVTYEP--------YLVTDDWPIHPSE-IDVQLTVGACWQGGEVTTPRFTQYFRGSLSGLTIRPGKIATQKVISCLQACKEG------LDISSLESLGKGIKFHFNPAQSVLVMEADDLESINTAMTKVSYINSRQFPTPGLRKLHITTTVQCFGEDTCISIPEIKAMVMVLPPSEPR-------ITIAGVERLVWPSAQLRAPVG-----VALFKDIHIISTVTKTDATLSIARR------PGVLELMHNLDYCDVLVIGEELDPERESLEIHHSSLLGKHLDATN--STSGISIYGVDSMAHYEQAIRQVRYRNWKPGSLSERRFRLSCSELNGRYTSNEFNLEIGVVHSS--EAVEHVNHMAVQSQFMRPVHHPLVVHTVNSDHISGTPPAATVVIVMCIAALVVIVVLGIYRIHTTHQDSSKEDEEERKDPEMDWDNSNLN-SIEGTQIAEEVREEEPEEDEDEDEEDDDL-------------------AGDLSSAESEDSDEDEETNIQKG---------KVKGKLEWDPSTLPY---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "R4GEC6-1", "uniprot_id": "R4GEC6_DANRE", "id": "R4GEC6-1", "name": "Calsyntenin-2", "aln": "-----MKRKLMLMLLALGLSCVR----------------AHRVNKHKPWIETSYHGVITENTDEVLLDPPLVALDKDAPVPYAGEICGFHVQGLSAPFEAVLLNGTSGEGRLRARGPIDCERHREFSFIIQAHDCGTGPQGHGQKRSHKAAVRVQVGDVNEFSPVFGQLEYHGSVTEGKVYDSILQVQASDQDCSPQYSQICNYQITSPDTAFAVDRNGNIRNTESLSFEKKSHYKIRVTALDCGQKRAMQEAIVHIHVKPICKPGWQGWRKLVDYEPG-AGSKLLFPKMHLETCEGSVS-----WIRTTVELETSGVGRGCD----SERSLQKLCGSSSGSTALLPATGGVCNWTVTLVRDSGRDSDLAYRFDGHQAAKIPDWVVPQN--LTDQFTITTWMKHGPSPGQ-RAEKETLLCNSDKTEMNRHHYSLYVHNCRLVFLLRTDYTQTDS--FRPAEFHWKLEQICDKEWHYYVLSVDFP-VVTLYVDGVTYEP--------YLVTDDWPIHSSQ-IDVQLTVGACWQGGEVSKAKFSQYFRGSLSGLTIRPGKIESQKIISCLQACKEG------LDITSLENLGQRIKFHLNPAQSVLVMEAEDLEQMNGALRKVSYINSRQFPTMGSRHLRISTAVQCFGEDVCISVPDIEVVVMVMQPSEAR-------ITITGAEHLTIP--AYDLALG-----LSLFRDLHIISTVTKRDKVTNMDHR------SSAKETAHNLDYCDILVLGEELRAGLESLELHHSALLGKHLEYAN--SSTGMSIYGVDSISHYTEVIRQVRYQSRR-AVDSVRTFRLTCSELNGRYTSDQYTLQVNILHSE--EAREHVNHLMTPPKSMQITHRTVMESNNY--FNLVVPAVSTSVVVVCIAALL-VVLLGVYQLNQTQNKDSIQTHTLA-EEQVDCEGSSLSITVNPLQNCQELQS-----AEVTEEEEDEE-------------------DCAISSTESDSDEEETDTPFTHR-----------QTKQQWGKATLHC---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9V498-1", "uniprot_id": "CSTN1_DROME", "id": "Q9V498-1", "name": "Calsyntenin-1", "aln": "MTFHKTFGYGCIVLICFELLFAGVETS--------SENDDEYLTQKEIILEKSYHGLIRENETLVEITPLIKVNEE--------KICNFHILKKPYHEIPFKIELVNNLGILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMKESAP-IMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDISNCTSGQKVK-------DLLPHG---AEWTKELSYDEG--LEPIFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQS---LENRLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCK-NESSLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKN------NGKLEEKNHIDSCSVVVFP-SLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPK-QTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIARLKNNQKYIEHHQPCPKISDDGLIWDDSALTITINPMQADVTSDASSESENSESEDEEALKDG--------FTHINQLEWDNSNIFQQ--", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : * :.::: :*.****:* ** * : * : . :: :** *:: . :: ... * *:*: .::** ::.: * * * *. * *:.* *:: * ****::*.* : * * **::*:.**:*:* *:**:* :.::*:*:* . * .*::*.:*.*:*** **.. . :: : *.* **. * : * :.*: :*:. : . : ::* .* : * *** :*: *: . . :: *:*. :. *** . * **: *** :** * *. : ::*** .. :* :: : :: *:* ::*... : ** ::*.:*. :***** :*:*:****:**** :: : * * ***::*:: ::**:***:**:.*: . * *::**. :* * :***:*.:. : .*::***:*. :: : *.*.:: :.: ..: : : *.* :* * *: .. :. . : : * . : :...: .:: : **.***::* ** * *.:.: : ::* :: .: :* :.. :** . . : .. : * . . : : :::: . : .: * :::* *.::*: .* . * :::. . :: . .. * .: * .:: .* :.:: : * . : * *::.*:: ..:*.*.::.* : ::* : .* : :. .. . . : : .: . . : : . : . * : . . . : : :* .:..:.: : : : *. : : ", "identical_positions": 190, "similar_positions": 320, "identity": "18.34%" }, { "cls_id": "homologset.agr.HGNC:17449", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9JKJ9-1", "uniprot_id": "CP39A_MOUSE", "id": "Q9JKJ9-1", "name": "24-hydroxycholesterol 7-alpha-hydroxylase", "aln": "MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAG-HSGTLLQAILEVVETET-RQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0M2G5-1", "uniprot_id": "A0ABK0M2G5_RAT", "id": "A0ABK0M2G5-1", "name": "24-hydroxycholesterol 7-alpha-hydroxylase", "aln": "MGIMELFSPIAIAVLGSCVLFLFSRWKNLRGPPCIQGWIPWIGAGFEFGKAPLEFIEKARIKYGPVFTVFAVGKRMTFVTEEEGINVLLKSKHVDFELAVQRPLYHTAWIPKNIFFALHEKLYVLMKGKMGTFNTHHFTGQLTEEFHDQLEGLGTHGTMDLNDFVRYLLYPATLNTLFMKGLFLTDKRKIKEFYQHFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGDIKTHGSAG-HSETLLQAVLGMVETET-RLHSPNYGLVMLWASLANAAPIAFWTLAYILSHPDLHRTIVESISSVFGTAGKDKIQVSENDLKKLLLIKWCILESIRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQAKFSSFGGCPPASREMPN-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9NYL5-1", "uniprot_id": "CP39A_HUMAN", "id": "Q9NYL5-1", "name": "24-hydroxycholesterol 7-alpha-hydroxylase", "aln": "---MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q5VSI8-1", "uniprot_id": "Q5VSI8_DANRE", "id": "Q5VSI8-1", "name": "24-hydroxycholesterol 7-alpha-hydroxylase", "aln": "---MEWITLILTVSVVIISFHLLFGKSHPNAPPCIRGWIPWFGAAFEFGKAPLHFIQQARAKYGPVFTVVAAGKRMTFVTLNEDFRVFFTSKDVDFEQAVQEPVHNTASISKDNFFESHPTCSAIIKGRLTPGNTAMLSPHLCEEFNDHLESLGSEGSGQLNELIKSVMYPSVMSNLLGRCNSPSSALSRQEFLEKFTTYDEGFEYGSQLPEMFLKEWSNSKHWLLSLLRKMVIKSEETLYSESDRKTLLQHLAASISEQY----LPNYGLLLLWASLANAIPVTFWAVAFILSNPTAYKIVMDQINSVLGRQDKQKTKVTLDDLQQMPYVKWCIMEAIRLRAPGAITRKVVRPLKLQNYVIPPGDMLMLSPYWAHRNPKYFPDPEDFKPERWETADLEKNVLLEGFVAFGGGKNQCPGRWYAIMELHMFVALILYKFEFAQLDPMPKPSPLHLVGTQQPDGPCTVRYKHR-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** :: : :.*: .: ****:*****:*..:*******.**::** ****:**:.* *:*****: :*.:.*::.*:.**** *** ::.** *.*: * * ::**:: . * :: * **::::**.**:.*: :**:::: ::** .:. *: : :. . :** : * .***.********* :*::**:**:*:* *:.* : . : : . **** :. : *****::***:*:** *::**::.::**:* :: ::: *.**:* .*:* :*: :**::: :***::*::**:***.******:*::: *: :*.**:*****:* ********:** ******: *:*:* :*: *:***.** ***.**:*::*::: : *:***:: : ***:** : .* * . . ", "identical_positions": 193, "similar_positions": 153, "identity": "40.89%" }, { "cls_id": "homologset.agr.HGNC:1745", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D4A8S5-1", "uniprot_id": "D4A8S5_RAT", "id": "D4A8S5-1", "name": "Cell division cycle 7-related protein kinase", "aln": "--------------------------------------------------------------------------------------------MEEPMAFSPLRGCDRCPADDSLKKYEQSVKLS-GIKRDIEELCEAVPQLVSVFKIKDKIGEGTFSSVYLA-------TAQLQ----EGREEKIALKHLIPTSHPVRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKCHGVIGHKGPLSR--PAPKNVDQHITTKTSVKRSYANAQIHIKQGKDGKEGSVGLSVQRSVFGE----------------RNFNIHSSISHES-PAEKLIKQSKTVDIMSRKLATKKM-AVSTKAVN-SSMRDSARS-------CPAALTCDCYGTDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSILCS------KEVPAQDLRTLCERLRGPDSANPKSAVDPPGNTGHHPAASESTDHKAP-HAPASPAQHSEDSLYKRGSGGGRRHPRDRTANPEGWDSVPDDAYDLLDKLLDLNPASRITAEAALVHPFFKDVC----------------------------------------------------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z0H0-1", "uniprot_id": "CDC7_MOUSE", "id": "Q9Z0H0-1", "name": "Cell division cycle 7-related protein kinase", "aln": "--------------------------------------------------------------------------------------------MEEPMAFSSLRGSDRCPADDSLKKYEQSVKLS-GIKRDIEELCEAVPQLVNVFKIKDKIGEGTFSSVYLA-------TAQLQ----EGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCSRNKYHGVVGHKGLLSR--PAPKTVDQQCTPKTSVKRSYT--QVHIKQGKDGKERSVGLSVQRSVFGE----------------RNFNIHSSISHES-PAEKLIKQSKTVDIISRKLATKKT-AISTKAMN-SVMRETARS-------CPAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCS------KEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKAS-RVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFFKDMCS---------------------------------------------------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O00311-1", "uniprot_id": "CDC7_HUMAN", "id": "O00311-1", "name": "Cell division cycle 7-related protein kinase", "aln": "------------------------------------------------------------------------------------MEASLGIQMDEPMAFSPQR--DRFQAEGSLKKNEQNFKLA-GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLA-------TAQLQ----VGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG--PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGE----------------RNFNIHSSISHES-PAVKLMKQSKTVDVLSRKLATKKK-AISTKVMNSAVMRKTASS-------CPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCS------KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL---------------------------------------------------------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "B0UYI0-1", "uniprot_id": "B0UYI0_DANRE", "id": "B0UYI0-1", "name": "non-specific serine/threonine protein kinase", "aln": "--------------------------------------------------------------------------------------------MEE--ANTVQR-----SSHRSVEKGRSRHKISRDVETEIAYLYEVLPQLSRIFRIIDKIGEGTFSSVYLA-------EAQMT----DSSRRLFALKHLIPTSHPVRIAAELQCLTVAGGTENVMGVTYCFRKEHHVVIVMPYMEHQTFVDIVGLLSFEDVRHYIYHLLKALKHIHKFGIIHRDIKPTNFLFNRQKREYALVDFGLAQGTPDTQIELLKVVKSKGHKGGGSSKMVEESLGKQKLVPLP-PNSRNPAVQSSTKAPAKRPCPPSRVKHSKELMGLDKAP-----RSVFGE----------------KSINSTNSHKPGSDKVEGLLSKPKKEEVIPRKIVSAKHRSVPVRAPLNQKQKLPAESQKPKPAAVNPLLTCNCYMTDRVCNICLSRKQQVAPRAGTPGFRAPEVLTKCPNQGTAIDMWSAGVILLSLLSGRYPFFKANDDLIALTQIMTIRGSKETIEAAKTFGKSIVCS------RELPRLDLRILCETLRGLRSWDDASLP-AEFQASHNPAEEKEE--------AESPALKSTGSRLCRSS---------AELKEIGWDRVPDEVYDLLDKLLDLNPATRITASTALQHPLFKDMSE---------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9W3Y1-1", "uniprot_id": "CDC7_DROME", "id": "Q9W3Y1-1", "name": "non-specific serine/threonine protein kinase Cdc7", "aln": "MADR---VMCQELATPGSHYRRPK--TGVPSTNVVYANG----GGSWRAAPRQTQRLPRQTVQQYATGTPATGSAGRHSGR--------AFATAGATEEQTVEFNG-AAVMGLPATPRTTKQARNKSEEAINDLLTRIPDIGKLFDVHSRIGNGTFSTVLLG-------TLRRESHLPDSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDFYTRMDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVNPPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEESNKMPLKPVNDIAPSDAPEQSVDGSNHVQPQLVQQEQQQLQPQQQQQQQQQQQQSQQQQQPQQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSA-----AAANNAKCVCFANPSVCLNCLMKKEVHASRAGTPGYRPPEVLLKYPDQTTAVDVWAAGVIFLSIMSTVYPFFKAPNDFIALAEIVTIFGDQAIRKTALALDRMITLS------QRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFNCLCEDSDYLTEP--------------------LDAYECFPPSAYDLLDRLLEINPHKRITAEEALKHPFFTAAEEAEQ----TEQDQLANGTPRKMRRQRYQ--SHRTVAASQE-QVKQQVALDLQQAAINKL-----", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q9VJ90-1", "uniprot_id": "CDC7B_DROME", "id": "Q9VJ90-1", "name": "non-specific serine/threonine protein kinase", "aln": "MDKKEVQHHRSQQAMTKSLYAIGMGLLGKSATNMDCANTNLESAGKSSSTNYNRNRFYNERFVPMASGTMPSVSGTNHHSRHQQLLLQQAPKCTADLNEKLVKINRQNANKELSTIQAKDMQSVDKNEEALKELQESIPEINKIFDVHCRIGSGTFSTVLLG-------TLQRERGLVETQRRRFAIKHHNPTNHPERILRELECMYRIGGVENVIGINCCIRYNDNVAFIMPYMTHDRFHDIYRSLNFPEIRDYLRNLLIALRHVHKFNVIHRDVKPSNILYNRRTGKFLLCDFGLAQRIADDGSVVQSSDLSSREVFSILRDLENG---------------RSVTLTDGNS------AQAEAEDYMARRRMRALGGGGSVERAVTGP----------------PSIQKLREQAGGHLTKKDVANQRADTMR-----LLNRLRLVSPNADPNNYVVSTNTS----------------------------KKEMHASRAGTPGYRPPEVLLRYPKQSTAVDVWAAGVIMLSLLSGLHPFFKAPHDCGALAEIINLFGDMPVRKTAFLLDRLILLA------QKVNTLDLRRVCMRFRHADFFLAPEIQRKYQRPDGTTEMCRSCEQPTFNCLCSNSGHNLER--------------------YDGLDIFPAVAYDLLSRLLEVNPQKRITAEEALKHPFFSDQHRITPGIPLHQQQLIMHQQQHIMQHQQHLQRSRETLPSSAARTLKAFVCYPMEITSTASQAAGNI", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P06243-1", "uniprot_id": "CDC7_YEAST", "id": "P06243-1", "name": "Cell division control protein 7", "aln": "----------------------------------------------------------------------------------------------------------------MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSMISSQNDYDNYANTNHDG----------------------------------------------------------------------------------GYSMRNHEQFCPCIMRNQYSPNSHNQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNE--------------------------TRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNMDAVDAYELK-----------KYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLDGESTDE------------------DDVVSSSEADLLDKDVLLISE------------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . : : * :* : : : :**.****:* . : . .*:*: *. * ** **: : * ..* : . * . :*: *: * : : . ::.*: .*: **: :*. .::***:**:*:*:* . . * *****: . . . :: * **** *:*.**** : * * :*:*:.***:**::. .*:::: .* :* :: .: * : * . . : . .*: . : . :::*.: ::::* .* :*. * .:*. ", "identical_positions": 74, "similar_positions": 101, "identity": "9.64%" }, { "cls_id": "homologset.agr.HGNC:17450", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O09158-1", "uniprot_id": "CP3AP_MOUSE", "id": "O09158-1", "name": "Cytochrome P450 3A25", "aln": "MELIPNLSIETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLG---TIFNYYDGMWKFDEDCYKKYG--KIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVG---------FMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEE--KGEPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKER-----LASNQKNRVDFLQLMMNTQN-----SKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK--APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEING----VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISRE-PIFQPEKPIILKVVSRDKPRTGS--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3Z2W7-1", "uniprot_id": "D3Z2W7_MOUSE", "id": "D3Z2W7-1", "name": "Cytochrome P450 3A", "aln": "MELIPNLSIETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFG---TIFNYFDGMWKFDEDCYKKYG--KIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVG---------FLKKSITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEE--KGEPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKER-----LASKQKNRVDFLQLMMNTQN-----SKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK--APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEING----VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISRE-PVFQPEKPIILKVVSRDKPRTAS--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "D3YYZ0-1", "uniprot_id": "D3YYZ0_MOUSE", "id": "D3YYZ0-1", "name": "Cytochrome P450 3A", "aln": "MELIPNLSIQTWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFG---NIINYLDGMWKFDDDCYKKYG--KIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPVG---------FLKKSITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEE--KEEPINMKDIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDR-----LDYNQKNRVDFLQLMMNTQN-----SKGQESLKALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK--APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHG----VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQ-PIFRPEKPIILKFVSRDKPRTGP--------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q64581-1", "uniprot_id": "CP3AI_RAT", "id": "Q64581-1", "name": "Cytochrome P450 3A18", "aln": "MEIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFG---TIFNYGDGMWKFDDDCYKKYG--KIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMG---------FMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEA--KGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNR-----LDSNQKNRVDFLQLMMNTQN-----SKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK--APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEING----VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQ-PIFQPEGPIILKLVSRD--------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P05183-1", "uniprot_id": "CP3A2_RAT", "id": "P05183-1", "name": "Cytochrome P450 3A2", "aln": "MDLLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLG---TVLNYYKGLGRFDMECYKKYG--KIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVG---------IMGKAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAE--TGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETR-----LDSKHKHRVDFLQLMLNAHNN----SKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK--APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDG----LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQ-AILEPEKPIVLKVLPRDAVINGA--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P51538-1", "uniprot_id": "CP3A9_RAT", "id": "P51538-1", "name": "Cytochrome P450 3A9", "aln": "MDLIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLG---TILAYRKGFWEFDKYCHKKYG--KLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVG---------ILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSE--EGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENR-----MKEKEKQRMDFLQLMINSQN-----SKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK--AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEING----VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQ-GLLQPEKPLLLKVVSRDETVNGA--------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9HB55-1", "uniprot_id": "CP343_HUMAN", "id": "Q9HB55-1", "name": "Cytochrome P450 3A43", "aln": "MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLG---TILFYLRGLWNFDRECNEKYG--EMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG---------FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE--NSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESR-----LKDKQKHRVDFFQQMIDSQN-----SKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK--APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING----VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL-PILQPEKPIVLKVHLRDGITSGP--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1N818-1", "uniprot_id": "A0A8M1N818_DANRE", "id": "A0A8M1N818-1", "name": "unspecific monooxygenase", "aln": "----MFFSAETWTLLAFLVALLVIYGSWPHRYFKKLGIPGPKTIPFFG---TMLRYKDGFHVFDMDCFEKYG--RIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNG---------ALYDAVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAK--RGESADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQ--APVDYETLMSMDYLDAALSESLRLYPVAARLERVCKKTVEING----LLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFN-GLLSPKDPIKLKLQPRKLSQSPDVCNNNQKS", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VG82-1", "uniprot_id": "CP9F2_DROME", "id": "Q9VG82-1", "name": "Probable cytochrome P450 9f2", "aln": "------MLWEFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQYFVRLVLDAMKYR------QEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKLVQRN--------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "A0A2U8U1P3-1", "uniprot_id": "A0A2U8U1P3_DROME", "id": "A0A2U8U1P3-1", "name": "", "aln": "------MLWEFLALFAIATALFYRWASANNDFFKDRGIAYEKPVLYLGNMAGMFLRKRAMLDIVCDLYTKGGSGKFFGIFAQRQPLLMVRDPDLIKQITIKDFDHFINHRNEFDTSSDDDPHDMSNLFSSSLFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQN--MKFILLFALKSLNKILKVEIFDRKSTQYFVRLVLDAMKYR------QEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKEL--------KYLDQVVSEVLRKWPPAIAFDRECNK---------------------------------------------------------------------------EAKAVIYYLLKDYRFAPAKKSCIPLELISSGFQLSPKGGFWIKLVQRN--------------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : : *.. :: .: : **. **. ..: :* :: .: : * * .::*:: *.: : * :** : :*: :.:: : . : .:: .* *: *: ***:**. ::::*. :: : . : : : : :*. :: **::.* .::::*::: ::.* **: : ::: : :: : : : :.. :* . :: : . * : * *::: ::::: . : : ** :: :* .:::*..:: :: : : : * . : ::* :*:: . . .*** .:.* ** :* . * .:. * .: *: : . ..:: :*::: : *: : :*. *. ", "identical_positions": 56, "similar_positions": 163, "identity": "10.29%" }, { "cls_id": "homologset.agr.HGNC:17451", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q924T8-1", "uniprot_id": "CLTR1_RAT", "id": "Q924T8-1", "name": "Cysteinyl leukotriene receptor 1", "aln": "-------------MVGAENMTASFSNNRCHDTIDEFRNQVYSTMYSMISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWFFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLLSKSYQDEKNNTKCFEPPQDKQTKKYVLVLHYVSLIFGFIIPFVTIIVCYTMIILTLLKNTMKKNLPSRRKAIGMIIVVTAAFLVSFMPYHIQRAIHLHFLHSETRSCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYIPKKKASLPEKGEEMCKE", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99JA4-1", "uniprot_id": "CLTR1_MOUSE", "id": "Q99JA4-1", "name": "Cysteinyl leukotriene receptor 1", "aln": "MYLQGTKQTFLENMNGTENLTTSLINNTCHDTIDEFRNQVYSTMYSVISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWLFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCIGIWIFVILTSSPFLMYKSYQDEKNNTKCFEPPQNNQAKKYVLILHYVSLFFGFIIPFVTIIVCYTMIILTLLKNTMKKNMPSRRKAIGMIIVVTAAFLVSFMPYHIQRTIHLHLLHSETRPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYVPKKKASLPEKGEEICNE", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y271-1", "uniprot_id": "CLTR1_HUMAN", "id": "Q9Y271-1", "name": "Cysteinyl leukotriene receptor 1", "aln": "-------------MDETGNLTVSS--ATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : *:*.* ******:********:**:*********.***********:************:******************** *:********:***********************:*********************:**************: *. :*************::*:*::**:******:.******* **************::****:.*::******:*****************:****:**.**:.*************************************:************:**:*:***********:*: ", "identical_positions": 284, "similar_positions": 42, "identity": "80.68%" }, { "cls_id": "homologset.agr.HGNC:17452", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8VHT6-1", "uniprot_id": "AS3MT_RAT", "id": "Q8VHT6-1", "name": "Arsenite methyltransferase", "aln": "MAAPRDA-EIHKDVQNYYGNVLKTSADLQTNACVTPAKGVPEYIRKSLQNVHEEVISRYYGCGLVVPEHLENCRILDLGSGSGRDCYVLSQLVGQKGHITGIDMTKVQVEVAKAYLEYHTEKFGFQTPNVTFLHGQIEMLAEAGIQKESYDIVISNCVINLVPDKQKVLREVYQVLKYGGELYFSDVYASLEVSEDIKSHKVLWGECLGGALYWKDLAVIAKKIGFCPPRLVTANIITVGNKELERVLGDCRFVSATFRLFKLPKTEPAGRCQVVYNGGIMGHEKELIFDANFTFKEGEAVEVDEETAAILRNSRFAHDFLFTPVEASLLAPQ------TKVIIRDPFKLAEESDKMKPRCAPEGTGGCCGKRKSC", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q91WU5-1", "uniprot_id": "AS3MT_MOUSE", "id": "Q91WU5-1", "name": "Arsenite methyltransferase", "aln": "MAASRDADEIHKDVQNYYGNVLKTSADLQTNACVTRAKPVPSYIRESLQNVHEDVSSRYYGCGLTVPERLENCRILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTEVQVEVAKTYLEHHMEKFGFQAPNVTFLHGRIEKLAEAGIQSESYDIVISNCVINLVPDKQQVLQEVYRVLKHGGELYFSDVYASLEVPEDIKSHKVLWGECLGGALYWKDLAIIAQKIGFCPPRLVTADIITVENKELEGVLGDCRFVSATFRLFKLPKTEPAERCRVVYNGGIKGHEKELIFDANFTFKEGEAVAVDEETAAVLKNSRFAPDFLFTPVDASLPAPQGRSELETKVLIRDPFKLAEDSDKMKPRHAPEGTGGCCGKRKNC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9HBK9-1", "uniprot_id": "AS3MT_HUMAN", "id": "Q9HBK9-1", "name": "Arsenite methyltransferase", "aln": "MAALRDA-EIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*** *** **:****.***:*** *******.*** *: **.:**::******:* *******.:**:**** ********************:***:******: *****: **::* **:***:.****:** ** *.****:.**:***:************:**:*.*:***:**********:***:.*:*::****************:**::*:************::**: ***** *:************** .** *: **:*:***** ******:*********** * *******:*:***** ***: *: .* :. * :* *******:**.**.* .*:.:*****.:*.*", "identical_positions": 269, "similar_positions": 70, "identity": "71.54%" }, { "cls_id": "homologset.agr.HGNC:17466", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "A0ACD6B6L3-1", "uniprot_id": "A0ACD6B6L3_DANRE", "id": "A0ACD6B6L3-1", "name": "", "aln": "-----------------------------------------------------MFGCQGD-GLRVRSWFTLISGLVECLGFAGAVFGWASLVFVLKNEGYFSSLCVNTTING---TAVEDCSRQDEQFSLIFTIASFMNNFLTLPNGFLFDRFGTTVARLLG--ISVYSTGMLLIAFSTTASSILLFPALSFISVGGILFLMTNIQVGNLFGTHRSTIITLYNGAFDSSSAVFLIIKLLFEDG---VSLRGCFLFMACCSVIHLFRTFVLMPRT--HIPYPLPENYTYGIN---CGGTQDYTIAKVEEKNIQTSQAE--EEEAFTETSPQGQNTSKMER-------------------SFKSCFLSWFFLWHLLWLSVMQLRHYLFIGTLNPMLNHLTAGDPSLVSRYTNAFAFTQLCGILCAPWNGLLMDRHKGK----QREPGQSEQEADLKAAILSLSLTALQCVLFSVCAATPILPLQYLTFILQVLNRSFLYGGNAAFISVAFPSVHFGKLYGTVMALSAVVSLLQYPCFALIKGTLGGDPLYVNIGLTVL-SLLAFVNPLYVYLHCRRQATQRRAAKKTSSS-------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "E7F4C3-1", "uniprot_id": "E7F4C3_DANRE", "id": "E7F4C3-1", "name": "", "aln": "-----------------------------------------------------MMAYKGSSGKVVRYKLTLATGLLECLCFAGVVFGWASLVFVLKTDGYFGDLCSNATDAGG--EFSSDCGLQDEHFSLVFTVASFMNNFLTLPNGFLYDHFGTMATRLLA--IFLYTTGTLIVAFSNKALSVLLFPALSFIAVGGILFLMTNMQVGNLFGSHRSTIITVYNGAFDSSSVIFLIIKVLYEKG---VSLRSSFLFLSACNLIHLIRTLFLMPKS--HIPYPIPQDYQYGIS---CAKSNSYNVEEYEAKREASSDRSRRAEEELLETDSIKLTDNPEKD-------------------SFRSCVLSWFFLWHLVWLSVMQLRHYFFIGTLNPMLNRLANQNPVTVSEYTNAFAFTQFCGVLCAPWNGLLMDRHKRK----PLDPDVSEREADLRSSILSLLLTSLQCFLFSICASIPFLPLQYLTFILQVLNRSFLYGGNAAFISIAFPARHFGKLYGLVMSLSAVVSLLQYPCFALNK-ALGGDPLYVNILLTIL-TLLAFIHPVYVFLHCRELAKHRENSRTLEASIQETSMY", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A2AVZ9-1", "uniprot_id": "S43A3_MOUSE", "id": "A2AVZ9-1", "name": "Equilibrative nucleobase transporter 1", "aln": "----------------------------------------------------------MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIA--IFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSSSAVFLVIKLLYEQG---ISLRSSFIFMSVCSVWHIARTFLLMPKG--HIPYPLPPNYSYGLCSRFGASKKENKAAEHETKELRSKECLPPKEENSGPEQQQQQEQQQQQQQQQEQHE----------QHSFRRCALSRRFILHVVWLSIIQLWHYLFIGTLNSLLTKLSGGDKVEVSAYTNAFAITQFFGVLCAPWNGLLMDRLKQKYQKAAKRTGSSSEAVALCSMVPSLALTSLLSLGFALCASIPVMQLQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESN-----AVYVSMGLA-IFLTLVHPFLVYRECRAEKTKSSVDA------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ABK0LPJ3-1", "uniprot_id": "A0ABK0LPJ3_RAT", "id": "A0ABK0LPJ3-1", "name": "", "aln": "MAQGSRQTDPRHFLLNPETVGTRGLIEVECLPKEISYTPLPVVSEVQDRICGPTSPQTMASQ-LPLYLATFLTGLLECIGFAGVLFGWTSLLFVFKAENYFLKPCEQDCVLGGNTTGLPDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLA--IFFYTCATLIIAFTSADTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITFYNGAFDSSSAVFLIIKLLYEQG---ISLRHSFIFLSVCSAWHVGRTFLLMPRG--HIPYPLPPNYSYGLCSRFCTRKEENEAAEHETKELQSRECQSPKEENSGPEQQQQQQQQQQQQQQQQQ------------QHSFRRCVFSHRFILHVVWLSIIQLWHYLFIGTLNSLLTKLAGEDSVKVSAYTNAFAITQFFGVLCAPWNGLLMDCLKQKYQKEAKRTGLSSEAVALCSMVPSLALTSLLSLGFTLCASIPVIELQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESK-----AVYVSMGLA-IFLTLVHPFLVYRECRVEKTKPSVDA------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NBI5-1", "uniprot_id": "S43A3_HUMAN", "id": "Q8NBI5-1", "name": "Equilibrative nucleobase transporter 1", "aln": "----------------------------------------------------------MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIA--IFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKG---ISLRASFIFISVCSTWHVARTFLLMPRG--HIPYPLPPNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELR-------------------------SFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQ-FGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLA-ILLTFFHPFLVYRECRTWKESPSAIA------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q04991-1", "uniprot_id": "FMP42_YEAST", "id": "Q04991-1", "name": "Protein FMP42", "aln": "-----------------------------------------------------------MTSTRTLRYAQVACACIWCLFSAGIIFGFAALKPILISEGVYHELCDPKDGDR------LLCTAQDLKLNFIFALSATVTNIMALPVGKILDMYGPRVCGIIGSCLLFLASGNFISAKHLVSLWDPYLVGYTLLAVAGPFVFISCFQLANSFPQRSGTVLALLTGSFDSSSALFLLYRLLYQNWFPTLNVSRFFTLYLIVPVFILACQLTIMPHSSYKTVNHIAKIAVEGLDENGRLIEGDTGSGIIPDEQERQSLIAIEREEDSIPSRPQRRKSVLETYVEDKLQKKSGGIFGVLHGKSAYEQIKSPWFYLMLLFALVAMLRINYFIATVRTQEEYLLNDPDLALKLNSIFDMLLPLGGAVSIPFIGLLLD------------------HTDTLSTLTILFTTSTAIGVFGLIPNS--FTWNLIGIVLLVVYRPFYYTVVSDYSSKVFGFDTFGTVYGLLSCICGIFNMSQNLLDKWTHTTFNMNPFPINLTLVILTVVFSLTLTFYIRSQILPKPVNERGLSSNYQTI------", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . . : *: ** :**:.:* :: :. : . * ** ::.::*::.: :.*::::* * : * : . . ::. : . : . :: * : . .::::.* :.::: :*:.* * : .*:::. .*:*****.:**: ::*::. :.: * : : : :**: : :. *: . .. ** * * * ::: : * **.*:.. : :. : : * :. *: ***:* . : : * *: * : . : : ::* *: *.* * : : : .* **.::* : .:..:..: * : : : : : .::: .. : . ", "identical_positions": 61, "similar_positions": 147, "identity": "10.25%" }, { "cls_id": "homologset.agr.HGNC:17468", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q62920-1", "uniprot_id": "PDLI5_RAT", "id": "Q62920-1", "name": "PDZ and LIM domain protein 5", "aln": "----MS-NYNVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVAVQKGEPKEVVKPVPITS--PAVSKVTSTTNMAY--NKVPRPFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVSSPKVTSIPSPSSAFTPAHAATSSHASPPPVAAVTPPPLSASGLHASANPSAAQCSSPPNTGKPAVHVPRQPTVTSVCSESAQELAEG-------------------------------------------------------QRRG---SQGDIKQQNGPPRKHIVER-----------------------------------------------------------------------------------------------------NTEFYHIPTHSDASKKRLIEDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDWRPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGTTQSRSFRILAQITGTEHLKESENDNAKKAN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPEPSQQ----SASPLSAAESLESPGSNRPVVAGLRSAAAFKPVGST-SVKSPSWQRPNQAAPSTGRISNSASSSGTGAPMKPAVGPPQPSDQDTLVQR-------------------------------------------------------------------AEHIPAGKRTPMCAHCNQAIRGPFLVALGKSWHPEEFNCAH--CKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGSTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8CI51-1", "uniprot_id": "PDLI5_MOUSE", "id": "Q8CI51-1", "name": "PDZ and LIM domain protein 5", "aln": "----MS-NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVSVQKGEPKEVVKPVPITS--PAVSKVTSTTNMAY--NKAPRPFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVSSPKVTSIPSPSSAFTPAHAATSSHASPTPVAAATPLHLSASGLHVSANLSADQCSSPPNTGKPAVNVPRQPTVTSVCSESAQELAEG-------------------------------------------------------QRRG---SQGDIKQQNGPPRKHIVER-----------------------------------------------------------------------------------------------------NTEFYHIPTHSDASKKRLIEDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDWRPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGTTQSRSFRILAQITGTEHLTESENDNTKKAN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STQEPSQQPASSGASPLSASEGPESPGSSRPSVAGLRSAAAFKPVGST-SVKSPSWQRPNQAAPSTGRISNNARSSGTGA----SVGPPQPSDQDTLVQR-------------------------------------------------------------------AEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAH--CKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96HC4-1", "uniprot_id": "PDLI5_HUMAN", "id": "Q96HC4-1", "name": "PDZ and LIM domain protein 5", "aln": "----MS-NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITS--PAVSKVTSTNNMAY--NKAPRPFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEG-------------------------------------------------------QRRG---SQGDSKQQNGPPRKHIVER-----------------------------------------------------------------------------------------------------YTEFYHVPTHSDASKKRLIEDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDWRPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGTTQSRSFRILAQITGTEHLKESEADNTKKAN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQR-------------------------------------------------------------------AEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAH--CKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IN44-1", "uniprot_id": "A0A0R4IN44_DANRE", "id": "A0A0R4IN44-1", "name": "", "aln": "----MSGKYSVVLQGPAPWGFRLQGGKDFNMPLSISRLTDAGKAAKAGVAVGDLVLSIDGISTDGMNHLEAQNKIKASSDKLNLSLQKASSLPKPD--VAPKDDCVEIIKPVPMTTSIPFSSDITNSTHITSSSNRSARPFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAGSPPIAFIPSTASAFAPASTAQYPNPLSPPTDGSP--------------------NHQPTVPRPSVYN---TPINLYSDENACEVAMG-------------------------------------------------------QRRGLLESQGESCQLNGLPRVPITET-----------------------------------------------------------------------------------------------------DIEFYHVPTHGDASRKRIMEDT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDWRPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGTSQSRSFRILAQITG----TESELDRAQEAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKK---------TTNEDVDDCQPSAHITCPVKTMIKAPAT--PVRNSAGFITPTFGVVSSSTPLGPALDR-------------PMPRPHPKDEASLVQR-------------------------------------------------------------------AEHIPAGTRTPMCAHCDMVIRGPFLVAMGKSWHPEEFTCAH--CSVSLSELGFVEEQGSVYCQHCYEEFFAPTCSRCHHKILGEVINALKQTWHVYCFLCASCQQPIRNDTFHLEDGEPYCERDFYSLFGTGCRGCDFPIEAGDKFLEALGGTWHDTCFVCTVCSVSLEGQTFFSKKGKPLCKKHAHALKI", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A1ZA47-1", "uniprot_id": "ZASP_DROME", "id": "A1ZA47-1", "name": "PDZ and LIM domain protein Zasp", "aln": "MAQPQLLQIKLSRFDAQPWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNFVITVQRGGSTWRPHVTPTGN-VPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDGGVKSIVNKQYNTPVGIYSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIKPNTKLSASTISSALNSHGYGGHSNGYSNGNSTPAPAPVASSQATATVATVAPSAATAATAAATPQAATATDSPAATASSSDNMSAYVADEPSSIYGQISAESVALAPPPPQPPTAGGGDQPFEYVTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAAAPKSPVSYPPQQQQQSPRPAPGGQNPYATLPRSNVGQQGGEAVEELQPEFEEEDCYEMDIEVALAASRQSQRGSSFTWPPPQDDSHLAPTAAPLYIPPPETQHVVVSNPVQQVPPLPPGGATARLDPQPVVGTSANGAPQWQSYSAPQLTTASARQLAEQESSSDSYTSTSTTTTTTSEEYQRMYAAQVQAYQMQEQSGSEFDYQVDYASTQDSVQDYPSGRRSAQECVDSLAVPLSTYKLVDMVREVTPSPVTTPTQTPAPAAPTTRRVVFNDEPEIKELPQLPAELETIPEASEAVEDREGLVIEQRCQILESERKFQPTPEIKIEIAPVRQIPPTKIPNPMPKEWINPMIRVLTTAPEVPFHLVECPFPRPCGDDFEAEAAAAEAAKTQEVPEPLPPQVSAAPPATVSVEPSPAPLRESPPRGSRLSQAMVTAPEFELKFAPPADQGIPLPEETEPYMPPPIDTKPYLREDYRPKSPFVSALTTAPDRPFEGHFDKDVPIHMIDLPTPKEHLSMCDALCTAPERGYTPLNPENAMHRVDEEQKQQELKKREFQVLDHEEELGIRPEPPQSVEYYETRRDQPRKSSAFAAMQAFQPSREPLSSNTVSNAGSVADTPRASIVSALKEETDLEYQKYLKAQQRNQKRLDYFHQKEEELSGLQGQQLTQLQRELSNQQQNLLSQQQLQQSKLLQLQQCVQSQELQQQVQHLTQKSQQQPPQANQQQQQQQQQRGTQQQQHSQVTQRTQQQQQQVPQQVTQQQQQEHSLLSQTTLAETQTLQANAQSQSSASYSSKATACSNSSSTVPPANTSTAFAPAPAPAPTSIPVRPSAIAVQSSYCSSQFDVHELIEETAEELEHSEVLFPPPSPLSHLTKQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVDAPKAPVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYNELNASPFPDRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIERRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNHAR----", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : .: .. *********.** ** :. :. .. : :* : ** *:.*:.:.. .: * :**: : . ..: :::*:..: :.. . : : .: . . .: :: *. .***. . ... : * .:* :.: :: . . .... . . .:: . . . : * *::. : * ** : : : * * ** ::: *: **:**: * :*.:. :: *:* .* ..: *: : : :: . . *. . : : .: .: :.: ... : . . *. : . : .* * *:* *: *****:.*:*: * *:.* *.: * .: :*****:* :**: *:*:::** *.:* ** *: :.*: : :* ** * * : : * *.****:.*** *: ** * * .* **:**** ::***. .:*. ** *:.* .****:*:.* .:*:**:**: ", "identical_positions": 130, "similar_positions": 188, "identity": "5.91%" }, { "cls_id": "homologset.agr.HGNC:17470", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "D3Z9P6-1", "uniprot_id": "D3Z9P6_RAT", "id": "D3Z9P6-1", "name": "Epigen", "aln": "MEERLRARSKNPPPFCLGGPEKELRQLQDMALRVPIAVCLLFKAMKAALSEETEAVPPSTTTQQSDWTLNITEADYIEEPVALKFSHPCLEDHNSYCINGACAFHHELKKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVGLLISAFLAVFYCYVRKRCLNVKSPYIICSG-GRPL", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q924X1-1", "uniprot_id": "EPGN_MOUSE", "id": "Q924X1-1", "name": "Epigen", "aln": "-----------------------------MALGVLIAVCLLFKAMKAALSEEAEVIPPS-TAQQSNWTFNNTEADYIEEPVALKFSHPCLEDHNSYCINGACAFHHELKQAICRCFTGYTGQRCEHLTLTSYAVDSYEKYIAIGIGVGLLISAFLAVFYCYIRKRCINLKSPYIICSG-GSPL", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q6UW88-1", "uniprot_id": "EPGN_HUMAN", "id": "Q6UW88-1", "name": "Epigen", "aln": "-----------------------------MALGVPISVYLLFNAMTALTEEAAVTVTPPITAQQGNWTVNKTEADNIEGPIALKFSHLCLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVGLLLSGFLVIFYCYIRKRCLKLKSPYNVCSGERRPL", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IWG0-1", "uniprot_id": "A0A0R4IWG0_DANRE", "id": "A0A0R4IWG0-1", "name": "", "aln": "-----------------------------MTQVLGLMLVLFLFSGLGEAQEKSEDVLLNNTTEN---LLYSHEIE--EEPLVLAAQRPCGSEHEGFCVNGVCSFSTELDTPICRCNEKYSGVRCEHIIMDTRSLSSPEEVIGISCGVVLFLGMLTVLLFFCLKKRCQKSPPPYKNCGSEHSV-", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *: : : : *:: : . .* : : *::: . * : * *:.* .: * .:*:.:*:**.*:* **. .**** *:* ****: : : ::.* *: *.*. ** *::. : .::: ::*** : .** *.. ", "identical_positions": 40, "similar_positions": 54, "identity": "21.86%" }, { "cls_id": "homologset.agr.HGNC:17474", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AYD4-1", "uniprot_id": "ESAM_RAT", "id": "Q6AYD4-1", "name": "Endothelial cell-selective adhesion molecule", "aln": "MILPARTPETSLLRVLFLGLSTLAAFSLAQMELHVPPGLNKLEAVEGEEVVLPAWYTMAREESSSHPWEAPFLIWFLEQEGKEPKQVLSYFKGSLSN-----KPGVTLVHSISTRNVSLRLDALQEGDSGTYRCSVNAYDSDGKNIGHSIKTIELKVLVPPAPPSCSFQGVPYVGTNVTLNCKSPRSKPTAQYQWERLAPSSQVFFGPA---------------LDTVRGSLKLTNISTAMSGVYVCKAQNRVGFAQCNVTLDVMTGSKAAVVAGAVVGTFVGLVLIAG-LVLLYQRRSKTLEELANDIKEDAIAPRTLPWTK---GSDTISKNGTLSSVTSARALRPPKAA------------PPRPGTFTPTPSVSSQALSSP------------------------------------------RLPRTDGPPPQAVSL--TPGGVSSSTLNRMGAVPVMVPAQSQAGSLV", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q925F2-1", "uniprot_id": "ESAM_MOUSE", "id": "Q925F2-1", "name": "Endothelial cell-selective adhesion molecule", "aln": "MILQAGTPETSLLRVLFLGLSTLAAFSRAQMELHVPPGLNKLEAVEGEEVVLPAWYTMAREESWSHPREVPILIWFLEQEGKEPNQVLSYINGVMTN-----KPGTALVHSISSRNVSLRLGALQEGDSGTYRCSVNVQNDEGKSIGHSIKSIELKVLVPPAPPSCSLQGVPYVGTNVTLNCKSPRSKPTAQYQWERLAPSSQVFFGPA---------------LDAVRGSLKLTNLSIAMSGVYVCKAQNRVGFAKCNVTLDVMTGSKAAVVAGAVVGTFVGLVLIAG-LVLLYQRRSKTLEELANDIKEDAIAPRTLPWTK---GSDTISKNGTLSSVTSARALRPPKAA------------PPRPGTFTPTPSVSSQALSSP------------------------------------------RLPRVDEPPPQAVSL--TPGGVSSSALSRMGAVPVMVPAQSQAGSLV", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q96AP7-1", "uniprot_id": "ESAM_HUMAN", "id": "Q96AP7-1", "name": "Endothelial cell-selective adhesion molecule", "aln": "MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLP--ANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKE-DQVLSYINGVTTS-----KPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPA---------------LDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAG-LVLLYHRRGKALEEPANDIKEDAIAPRTLPWPK---SSDTISKNGTLSSVTSARALRPP-HG------------PPRPGALTPTPSLSSQALPSP------------------------------------------RLPTTDGAHPQPISP--IPGGVSSSGLSRMGAVPVMVPAQSQAGSLV", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M1NGH6-1", "uniprot_id": "A0A8M1NGH6_DANRE", "id": "A0A8M1NGH6-1", "name": "", "aln": "MERRTSAKLHNYL-SIFTFLCCFSSGELAQLVLPYE----NVDVIQGKMVVLQASYS-STDFQKN------TVVWNYMQSATSTEMIISFVNGDFSHGTSQFAGRVGFFHNMPNTNLSLYINNTKVSDSGRYVCQVMIPGASGLTG-----TLNLNVKVPPSIPVCKVKEKPVLKANITLSCNSNEGKPAPKYKWIKTSPTSEVFFSPA---------------LNETAGTLKLNNLSSNMSGKYVCTSTNSAGEETCYINLEVITSTNAGMIAGVTFGCIVALILIVIFLIFMWTRRKDTEEDLANDIKEDAQAPKRVSWAKSGTGSDIISKNGTLSSIHTSSYPRDAHN---HHHYPH----SDTASIITATGSTAGYRSQPPVDATLERSLPGYNTNPAPTRGP-----FGPPSNNGGSQ--HTSMPRTAPAQPQIPRPPVLPTTVTAANISRMGGVPIMVPAQNQAGSLV", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9Q5H7-1", "uniprot_id": "A0A8M9Q5H7_DANRE", "id": "A0A8M9Q5H7-1", "name": "", "aln": "MEMLMDWRTPTFL-LLTSLL--LITGDSQRVEMPRK----DMEVIMGQMVVLEAWYTPTTSIDKN------TVIWSFMANDS--KQVISYSSGQIGIGSPDFRKRVGFAMSMPSANLSIFINNTQESDSGRYLCNVIIPGAAGLTG-----ELRLNVKVPPSTPVCSMTGNPVLRGNVTLSCKSGYGKPVPQYKWTKAAPLSEVFFSPMQKWRSCPQPLLVLGYLDERQGTLRLSNLTKSMSGKYVCRASNTAGTDSCHINLEVSTPNNAWVIAGATVGSVVGLMALVLFLIFILRRNRDTEEEMANDIKEDAQAPKRVSWAKSGTGSDIISKNGTLSSIATSPPVRDPNHPLQNNHYPFPPGASDTASILTTSGSTTTYRLRPGEPNPLHG-LPGYNASSTPNHTHRHHHHHHRHHNPGGINPNGSSTLRTEGPQPQAPRPLNMP--INNATLSRMGAVPVMVPTQNHAGSLV", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . * : * : . . :: : ::.: * *** * *: . . . ::* . . . ::*: .* . : .:.. *:*: : : *** * *.* . * . :.*:* ***: * * . * : *:**.*:* .**. :*:* : * :.**.* *: *:* *.*:: *:* *** : * .* * :.*:* * * ::**...* .*.* :. *::: *. .: *: ******** **: :.*.* .** *********: :: * . . .. :*.: * : . . . ** * :. : :.***.**:***:*.:*****", "identical_positions": 110, "similar_positions": 111, "identity": "23.21%" }, { "cls_id": "homologset.agr.HGNC:17479", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q96PM5-1", "uniprot_id": "ZN363_HUMAN", "id": "Q96PM5-1", "name": "RING finger and CHY zinc finger domain-containing protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------MAATAREDGASGQERGQ-----------------------------------RGCEHYDRGCLLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEECSTLFGEYYCDICHLFD-KDKKQYHCENCGICRIGPKEDFFHCLKCNLCLAMNLQGR-HKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEG-YRCPLCMHSALDMTRYWRQLDDEVAQTPMPSEYQNMTVDILCNDCNGRSTVQFHILGMKCKICESYNTAQAGGRR--ISLDQQ------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9CR50-1", "uniprot_id": "ZN363_MOUSE", "id": "Q9CR50-1", "name": "RING finger and CHY zinc finger domain-containing protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------MAATAREDGVRNLAQGP-----------------------------------RGCEHYDRACLLKAPCCDKLYTCRLCHDTNEDHQLDRFKVKEVQCINCEKLQHAQQTCEDCSTLFGEYYCSICHLFD-KDKRQYHCESCGICRIGPKEDFFHCLKCNLCLTTNLRGK-HKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEG-YRCPLCMHSALDMTRYWRQLDTEVAQTPMPSEYQNVTVDILCNDCNGRSTVQFHILGMKCKLCDSYNTAQAGGRR--VPVDQQ------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8M1PH56-1", "uniprot_id": "A0A8M1PH56_DANRE", "id": "A0A8M1PH56-1", "name": "RING finger and CHY zinc finger domain-containing protein 1", "aln": "---------------------------------------------------------------------------------------------------------------------------------MAATK-----------------------------------------------VGCEHYVRSCLLKAPCCGKFYVCRLCHDAEETHQMDRFKVQEVKCAVCNTIQEAQQICKECEVKFGEYYCDICHLFD-KDKKQYHCQPCGICRIGPREKYFHCTKCNLCLGTELKDK-HKCVENVSRQNCPVCMEDIHTSRVGAHVLPCGHLLHGTCFDDMLKTGAYRCPLCMHSAFNMKEYWKQMDEEISQTPMPTEYQDSTVKIICNDCQARSTVSFHVLGMKCSSCGSYNTAQDGGLMGTPAANTQTLPEEPDAEQHH", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q9VMD4-1", "uniprot_id": "Q9VMD4_DROME", "id": "Q9VMD4-1", "name": "", "aln": "MKNRQRTRRISLNENHNRYMGSGGIDVQIVTNTKEPNQVNLNSSSATTTSAEAALPASLPLAQIAQQPHTHPHPHPNPHLHQQHQLIVTPTTMTGKYHPAHAKLRRCKSTPSLNCDGMAEPMEEDQLHRFAACSRNPAAEAQQHAQPSCNSSSSSSDGSCNSNKCSSNICGAQPTTPESLRFGCAHYKRRAMFVTPCCNKFYKCRFCHDENETHHFDRKTLTELICSECNTRQTVREQCLNCGVRFGKYTCLICNLFDDADKQQYHCHGCGICRIGGAENFFHCEVCNMCLPIQLKIDGHRCVENISRSHCPVCLGDIHTSRIPCHIPDCGHLLHKMCFDQLLASGHYTCPTCQTSLIDMTALWVYLDDQAERMPVPLKYENQRVHIFCNDCHKTSKTKFHFIGLKCVHCGAYNTTQDVKRRLSLVTDEPSSA---------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :** ** ** * .:: :***.*:* **:*** :* *::** .: *: * *:. * .:: * :* . **:* * **:*** **:****. ******* *.:*** **:** :*: *:*:**:**.:**:*: ******: .*: ****** *::::* * * ** * * ::*. * :* : : *:* :*:: *.*:****: *...**.:*:** * :***:* : ", "identical_positions": 111, "similar_positions": 66, "identity": "25.11%" }, { "cls_id": "homologset.agr.HGNC:1748", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P09803-1", "uniprot_id": "CADH1_MOUSE", "id": "P09803-1", "name": "Cadherin-1", "aln": "-MGARCRSFSALLLLLQVSSWLCQELEPES--CSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSG-LDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVN-DPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATD-DGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9R0T4-1", "uniprot_id": "CADH1_RAT", "id": "Q9R0T4-1", "name": "Cadherin-1", "aln": "-MGARCRSFSALLLLLQVSSWLCQQPESESDSCRPGFSSEVYTFLVPERHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPELLTFPSFHQGLRRQKRDWVIPPINCPENQKGEFPQRLVQIKSNRDKETTVFYSITGPGADKPPVGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGSVAEGALPGTSVMQVSATDADDDINTYNAAIAYTILSQDPELPHKNMFTVNRDTGVISVVTSG-LDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENEVGARIATLKVTDDDAPNTPAWNAVYTVVN-DPDHQFTVITDPKTNEGILKTAKGLDFEAKQQYILHVTVENEEPFEGSLVPSTATVTVDVVDVNEAPIFVPAEKRVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTANWLEINPETGVISTRAEMDREDSEHVKNSTYTALIIATD-DGSPIATGTGTLLLVLSDVNDNAPIPEPRNMQFCQRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEQESLILQPRKDLEIGEYKINLKLSDNQNKDQVTTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSMPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEED", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P12830-1", "uniprot_id": "CADH1_HUMAN", "id": "P12830-1", "name": "Cadherin-1", "aln": "-MGPWSRSLSALLLLLQVSSWLCQEPEP----CHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTG-LDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILN-DDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATD-NGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q90Z37-1", "uniprot_id": "CADH1_DANRE", "id": "Q90Z37-1", "name": "Cadherin-1", "aln": "MACVTTVGLGVIFFLFRVFSSGYTHMSI----CTPGFELEEFVFKVHRNHLHSGKRLGKVTFNNCDGRTRTLFQSIDKRFEINTDGTVTLKRQVTLHEGHKVFSVHAWDSSGMKHTASVRVERVPAQVE--------SSSDVDLTKN-------KRVKRGWIIPPISVSENSKGPFPMRLVQIKSDYAIETRLAYKITGEGADLDPKGIFTIDRLSGWVSVTQLLDREKKASYKLRAHANGVDADVTEKPMDIIVTVTDQNDNKPVFTQNPFNGNVPEALEKGEVFMTVTATDADDKENTDNADISYVIISQDPPSPKPNMFAINPVSGGISVLEKG-LDREQWFRYTLVITATDMNGEGLSTTGTAVITVTDSNDNAPLFEQSSYTASVPENQVGVEVAKLPVTDGDEPESTAWSTKYQIIAGDKGGFFNISTGPSRLEGIITTVKPLDYEKTKQYILSVIVVNDDKFVGPLPTSTATVTVNVKDVNEPPEFIPKEKFISRPENLPVGSNLIPFTAIDPDTEKKQNITYRIGNDPSDWLNIT-GSGQIQVKNALDRESS-NVKDGKYKALILALDNDVESPATGTGTLVIELQDVNDNAPVINERTIKLCNRESAPVLLSITDKDLPPFAGPFKVEPQGDTSKNWSVFFNETG-HFLNIKPQSQLEQGEYKVVLRVADREGESQENIIQASVCDCKGEAFQCTDKQ--VAGIPLFGVLGVLGGILLLLLLALLLLMFLRRKSNSKKEPLLPEDDVRDNIYYYDEEGGGEDDQDFDLSVLHRGLDNRPEVFRNDVAPTFMPAPQYRPRPANPEEIGTFIDDNLKAADNDPTAPPYDSLLVFDYEGGGSDAGSLSSLNTSSSGNDQDYDFLNEWGPRFKKLADMYGGGED-", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0AB13A7X0-1", "uniprot_id": "A0AB13A7X0_DANRE", "id": "A0AB13A7X0-1", "name": "Cadherin-1", "aln": "----------------------------------------------------------------MEGDAHGCFICVICLVMLTTHGEIVPEYLAANQ--QENFMAYQRNSSNIWQNSITPDDFLIKVFS--------KPFNS------------IRRKRDWLIPHVSIVENDKGPFPKQVVKMKSTAADSMTMIYEITGTGANEPPINLFKVGKSSGILWVTKAVDREETEEYTLTVHATSNNRDYTEKPVQLVIKVLDQNDNKPRCTQNPYTGEVLERAKPNTPVMQVTAEDLDDP-TSSNSIVRYKLLKQEP---NSGVFHIDQTTGVISLALMGILDRETDAVYNLAVEAADMDGHGLSSTCMVAIKITDSNDHRPLFSQEYYAETVKENKAGEVVARLTVTDKDEPLTVNALSKFTIIQGNDRGFFNISTDHNGMDGIITTLKALDFEQANSFSLLIMVENEAPFALPFRTSTATVTITVLDVNEPPVFDLPEKQIIIYEDQSVGSMISKYTATDPDTDRAQKIRYKLRGDIANWLEITEDTGHITISSSLDREAK-FIRDGQYKVLVLAFD-DDDEPATGTGTFMIKLLDVNDNPPVLEQHKVQMCSTEPKPVRLTITDADEPENGPPFTTELHEEFKSNWTISSDSNS--SVLLSSLRPLAVGEHSLWLRLSDSKLLFQDSSLIVNVCDCKGDDGTCSSPR-YAASISTPLIFVFVA--VFCLLVLIVLLLFLKRRCGRKFQQFTKNEEDRDNIICYNEEGGGEQDQDFDIMLLCGG----PEVFYRDIAPTVLPTVVYRQLPEEDEDMENFIYENLCTADDEHYVAPFDSVLVFAHEGEGSKAGSLSSIQSSISDGGLEFQDLHSWGPPFRRLADLYAERQDE", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * : : . . : *.* :. : : . * . :*: .: . . : . : * **.*:** :. **.** ** .:*::** . : *.*** **: * .:* : : :* : **: :*** * * ** . : : .*.*:::::.* *****:* *: : *.* * . .* *:* * ** .: *: : * ::.*:* . .:* :: :* **: * **** *.*.: *:*::*.***:* ..*.:.* **: *:*. * * **:.. :: * *** * * : : : :: : * : *. :**:.* * **:* :.: * : * * * .: .******: * ****.* * *: : *: ** : :** :*** *:* *:: * ::**:*. :* * :*** :::. * .*::* * : . ******::: * *****.*: : :.: :*. :. * :.* * * * **..* . **:: :. : :.. * *::.: *:: * : * . : . ****:* * . *.: :: .:. : *:: ::**:**:*: * : ::: ***: *:******:*****: * * *** .*:***.:. * * : ::: .** :** :** : ..*:**:*** :** **.*.****:::* *. . ::: *:.** *::***:*. :: ", "identical_positions": 246, "similar_positions": 238, "identity": "27.64%" }, { "cls_id": "homologset.agr.HGNC:17481", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q63364-1", "uniprot_id": "PJA2_RAT", "id": "Q63364-1", "name": "E3 ubiquitin-protein ligase Praja-2", "aln": "MSQYTEKEPSVMDQDSSKAAWPRAAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVAKENTAGSSSLDQVHPSLPSETTVEKSETEIPTCGPALNQSTESNPSVATVCHSEEVRETLDSSTNLQNHAERECTPAVCNASSVQNGIVLVHTDSYDPDSKHDE-NDSLQLCAQAVEG-GRRQKVLGNAVFELENGEVERYADLCPSVPSLSGEIREESEELGSALLEKNSAGDAEAVHQDGQEFQRSSEDGIVRKRRQDDTDQGRQTENSTEDADCVPGHV--EQNTSERANHHGSSPEQVVRPKVRKVISSSQVDQESGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPSYSR-VTPREAERHRATAENGATASGRQEARENAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSEPDLDASPANDNAEEAP-", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q80U04-1", "uniprot_id": "PJA2_MOUSE", "id": "Q80U04-1", "name": "E3 ubiquitin-protein ligase Praja-2", "aln": "MSQYTEKEPSVMDQESSKAAWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVPKENTSGSSSLDQVHPALPNEPTVEKSETEISTCGPALNQSTESSPSIATVCHSEEVRETLESNTNLHNRTETEHTPAVCNVSSVQNGIMLVHTDSYDPDSKHDE-NGSLQLGAEAVEG-GRHQKGLGRAVFELENGEAEIYADLSPSVPSLNGEISEAFEELDSAPLEKSSTADAELVHQNGQEFQRSSEDGVVRKRRQDDTDQGRQTENSTEDADCAPGHV--EQNTSDRANHHGSSPEQVVRPKVRKVISSSQVDQEIGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPTYSR-VTQRETERNRVTSENGATASGRQESRDNAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDDSWETLPGKDENDPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSDPDPDASPANDNAEEAP-", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O43164-1", "uniprot_id": "PJA2_HUMAN", "id": "O43164-1", "name": "E3 ubiquitin-protein ligase Praja-2", "aln": "MSQYTEKEPAAMDQESGKAVWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVPKENSSGSSPLDQVDSSLPSEPIFEKSETEIPTCGSALNQTTESSQSFVAVHHSEEGRDTLGSSTNLHNHSEGEYIPGACSASSVQNGIALVHTDSYDPDGKHGEDNDHLQLSAEVVEG-SRYQESLGNTVFELENREAEAYTGLSPPVPSFNCEVRDEFEELDSVPLVKSSAGDTEFVHQNSQEIQRSSQDEMVSTKQQNNTSQERQTEHSPEDAACGPGHICSEQNTNDREKNHGSSPEQVVRPKVRKLISSSQVDQETGFNRHEAKQRSVQRWREALEVEESGSDDLLIKCEEYDGEHDCMFLDPPYSRVITQRETENNQMTSESGATA-GRQE-VDNTFWNGCGDYYQLYDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQP-AFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDP-QFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIEASAAPSSEPDPDAPPSNDSIAEAP-", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M3AZZ7-1", "uniprot_id": "A0A8M3AZZ7_DANRE", "id": "A0A8M3AZZ7-1", "name": "RING-type E3 ubiquitin transferase", "aln": "-----------MGQEAGKSAWPKPAGGYQTISGRRYGRRHAYISFKPFTDKQ-----RATSTVDCQNMQRTSDQKSQAMESKGNISSVLQTILPISCTNSVRPEINAAAHHPEGHNRRHSSLRRVP--KAPLNHFKRPKNDQVVPYDRKHCSGR--EKSKVWPIDENHKTNSKALS---YINIDAYEPDSSGAEEEDLSSDPSHAACRRLDGICELGGNVDSLDDSRSSLFR--KNRMKQMASSKDSTDLFDDTPDCQRT-----VKTNGKPSFFLEDGAPKCYGDTASAVSHKNKEQNNPGETFES----EMVVRPKIRKQTSETHLERRKRSEKEETGHLSGSAIRN-----KCGSAPPGFLAQTCP-ENEFLFNFPAMAL--SDLNSEDRKSEDEYAKVE--DEDDIWEDLENFGEKCEPSMKADESSSEFSEGEWSASWTS-DSGLDKERCTSEESWETLPGIDE-PPASRSSS---LEEVPSLNLALEEQTPLEEGEIPWLMYNEDSGSSSDEDPDGVSQFVHPGLFILDGNNNLEDDSSMSEDLDTEWRFLDEFGDGFGMAQAISYVDHSQLLTYMALEERLAQAMEAALAHLESLAIDVEQAHPPATEQIIDCLPQITMHAEN--IEQEQCCAICCCEYVKDEIATLLPCRHMFHKLCVTLWLRKSGTCPVCRHVLTPAVTTDPASLSSEQE--TSPSTHSASGGAC", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " *.*::.*:.**:.*******:**********:**** :: ** . : ::: ...::: . .. .:: . * . .. ::: . ..* ::. . :: : : .* .. :* *. ::. :.:..:.* . ::: * :. . :: *. . . : * * *:. . . . . *: *: :.:: : **: * .. : . : :. *: . .* ***. . . * *****:** *.:::::. ::.*: : * . *: :..* : .: ::: :* *. : : ::* .: * . . :: : : * . . **.*** *:****** . ** :*::.:*::******* ** * :*.* ** .*.* ***.********* *** . *****. : ..:*.:* *:************:*****.:* ::* *.**:*:*:****** *:***************:*********:*** *:***::: ** **: : :: * *****.***.**:**:*** ***:*:*** **::**:*********: :.*** .*: **: : :.*:... .. ", "identical_positions": 231, "similar_positions": 210, "identity": "32.35%" }, { "cls_id": "homologset.agr.HGNC:17482", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z282-1", "uniprot_id": "GP132_MOUSE", "id": "Q9Z282-1", "name": "Probable G protein-coupled receptor 132", "aln": "--------------------------MRSEPTNAAGNTTLGVTSVLQSTSVPSSETCH-VSYEESRVVLVVVYSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKV------EKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEVSRIHTGWKKWSTKTYVT---CSKDSEETHLPTELSNTYTFPNPAHPPGSQPAKLGLLCSPERLPEELC", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0A8I6AM45-1", "uniprot_id": "A0A8I6AM45_RAT", "id": "A0A8I6AM45-1", "name": "", "aln": "MTCFLVILSCQSHLHKGVHRTHIGATMRSEPTNATGNATA-VTSTLQTTSVPTS--CHTLSYEESRVVLVAVYSVVCMLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTMPLWIIYIQNQHKWSLGQQACKVTAYIFFCNIYTSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVVILVGLVNYPVFDMKV------EDSFCFEPLGIDSRIAGYYYLRFTFGFAVPLGVLAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLIKAASFSFYEGDRDAVCDFENRLYTVSTVFLCLSTVNSVADPIIYVLATDHSRQEVCRIHTGWKKWSTKTDVT---YLKDSEETHSPTALMNAYTFPSTVHLPGSQPVELGSLGSAGETA----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9UNW8-1", "uniprot_id": "GP132_HUMAN", "id": "Q9UNW8-1", "name": "Probable G protein-coupled receptor 132", "aln": "-----------------------MCPMLLK-NGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTE-------DKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSP-------CPAKRLIEESC", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4IEK2-1", "uniprot_id": "A0A0R4IEK2_DANRE", "id": "A0A0R4IEK2-1", "name": "", "aln": "-----------------------MVSGRVLTTFRDMMHATTVAQSIMTSMNQSSRASCEISHEADRIPLMVLYIVVFIIGLPANLATVYLTLHQVCRKNVLGIYLLSLSICDLTYLFTLPMWTVYVSRNHEWPWSSLACKITGFVFFNNMYISIFLLCCVSIDRYVAVVYAIESRGLRQKRIAAFVSFLIFIVVGLGHSPVFIMREGQVEEGS-HRCFEPSQSTTLVTGFNYARVCIGFCIPLAILIFTNRAILANVQASTGLQPHQKVKVRYLAVAVVALFLICFAPYHIILLMRAVIFHFPN--LQGKCHFEQHIYTPYKISLGLSTFNSAINPILYVLSSNNIRQEIRRGITSVCDRVLSSQRST---HSSQHNMHSSRSNSEPFPIKGGQMRTVCPTA----------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A8M9PLR3-1", "uniprot_id": "A0A8M9PLR3_DANRE", "id": "A0A8M9PLR3-1", "name": "", "aln": "------------------------------------MNVT----SLPTARSNHTSSCGPLYDEENPLPLVALYSTVLTVGLPANLITVFLTFLEVCRKNVLGVYLFSLTLCDLMYLSTLPLWAIYIHRGHRWEWGSLACKITGYVFFNNMYISIFLMCCVSVDRFVAVVYAVESRGLRRMRHAAIISVTIVAVVAIGHVPVFTMTEGNSEKISEKRCFEPSNPSSVVTGLNYARFFVGFFIPLCILTLTNFAILVNVQASAGLMTKTKVKVRNLAVAVVLFFLVCFTPYHVILLLRAVNFHVS----DGKCDFERHVYTPYTISLGLSTVNSALNPVFYVLASSSAQKKIYKG--------LQGLRS------------SSRSSSLA-------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " . :: : . : * . : *:.:* .* :*:*** *.:*:: :* : ***.:**:.*::*:* * *:*:* :*: . *.* . ***:*.::** *:* **:::**:* **::*****:**** *: * * :* :. :*.: : *** . **: : ::* * *. .** :** :: :** *: .:: * .* . * **: *:*** :**:**:***::**::*. * :. * :* ::** : * ***.*.. :*::***.:. :::: : . : . ", "identical_positions": 103, "similar_positions": 104, "identity": "24.64%" }, { "cls_id": "homologset.agr.HGNC:17485", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AXZ3-1", "uniprot_id": "P2R3C_RAT", "id": "Q6AXZ3-1", "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "aln": "------MDWKDVLRRRLASPNSDPKRKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQIPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRVSIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNE-NSADLDDT", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JK24-1", "uniprot_id": "P2R3C_MOUSE", "id": "Q9JK24-1", "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "aln": "------MDWKDVLRRRLASPNTDPKRKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQIPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNE-NSADLDDT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q969Q6-1", "uniprot_id": "P2R3C_HUMAN", "id": "Q969Q6-1", "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "aln": "------MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSE-NSADLDDT", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q803V3-1", "uniprot_id": "P2R3C_DANRE", "id": "Q803V3-1", "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "aln": "MANDITAHWKDLLRKRLASLKPD---GRTEEEKKAEESELFSKYYTEWKGGEKGEDDSFKHIPRFYYRLPAEDEVLMQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQVPPTTGDEAMISYESFLKVGEKAGTKCKLFFTARVYAKLLHNDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLHTGKIKIQDILACSFLDDLLELRDEELSKESQESNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTGTLTSVFLDRVYQACLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDMENKGYLNVFALNYFFRAIQEQMKIHGQEPVSFQDVKDEIFDMVKPKDPYKITLQDLVNSGQGDTVSSILIDLNGFWTYENREVLVANDTDSNAADLDDT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .**::**:***: :. ::*:* * ** :**:***:*****.*. :: :* ***************:************************************ ** *:****.**.*********.*** ****:*:*****.*.***:******************************************************************************:********************************:************************************.*:*.******:* *************************************:*********:********** ******:******************** **:****:**.*****::***************.*****.: *:******", "identical_positions": 387, "similar_positions": 46, "identity": "84.13%" }, { "cls_id": "homologset.agr.HGNC:1749", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1LR98-1", "uniprot_id": "F1LR98_RAT", "id": "F1LR98-1", "name": "Cadherin-10", "aln": "MSIYSFLRLFVLWACLPQFCCPELTFRRTPGLQQMTAESHVPRGDGK----------------ILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAG------------------TLFIIDEKTGDIHATRRIDREE--KAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ--PYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMG---------------------------------------------------------------------------------GQMG-----------------------------GLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAVGSVKATDAD-TGKNAEVDYRIIDGD------------------------------------------------GTDMFDIITEKDT------QEGIITVKKPLDYENRRLYTLKVEAENTHVDPRFYY-----------------------------------------LGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDS--TSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINN-----PKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEALLLPAGLSTGALIAILLCIIILL--VVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDA----------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P70408-1", "uniprot_id": "CAD10_MOUSE", "id": "P70408-1", "name": "Cadherin-10", "aln": "MTIYQFLRLFVLWACLPHFCCPELTFRRTPGIQQMTAESRAPRSDGK----------------ILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAG------------------TLFIIDEKTGDIHATRRIDREE--KAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ--PYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMG---------------------------------------------------------------------------------GQMG-----------------------------GLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAVGSVKATDAD-TGKNAEVDYRIIDGD------------------------------------------------GTDMFDIITEKDT------QEGIITVKKPLDYENRRLYTLKVEAENTHVDPRFYY-----------------------------------------LGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDS--TSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINN-----PKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDA----------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9Y6N8-1", "uniprot_id": "CAD10_HUMAN", "id": "Q9Y6N8-1", "name": "Cadherin-10", "aln": "MTIHQFLLLFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRSDGK----------------ILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAG------------------TLFIIDEKTGDIHATRRIDREE--KAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ--PYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMG---------------------------------------------------------------------------------GQMG-----------------------------GLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDAD-TGKNAEVEYRIIDGD------------------------------------------------GTDMFDIVTEKDT------QEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYY-----------------------------------------LGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDS--ISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINN-----PKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDS----------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24298-1", "uniprot_id": "CADE_DROME", "id": "Q24298-1", "name": "DE-cadherin", "aln": "-MSTSVQRMSRSYHCINMSATPQAGHLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDD---GNNSLVEYEILRERDFQYFKIDKESGIIYLKRP-IDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIP-YYTEVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDN-SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDG--DYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQ-KNGWHEKDIDDIRETIINYEDEGGGERD-TDYDLNVLRTQPFYEEK-----LYKDPHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQGWRI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. : : *: . *: . ... * .: *. *: :* : : : . :: . .. .: : . .*:*: :... . *:*: .** *.:*: :**:* : :.: : . . * *:: . * :.*.***** *:* : * *:.* : .: *: ::*:* ** **.: * *.**: : **.:: *:*** * :::. :.* ::::* :: .*:* *. ::* : ***** * : :. :**..* **.: .*:* * * *. * *.:.: *. * ::* * ... *:. .:: *: . . .::*:**: . .:: * * :.* * * *.****:: * . :..* . : *: . * ** * *** .: :: . * : .. :.*.. .*.* *.***: .: *: : : *: .. :* * * : *:***** : .: ** .**:::* : .* * .*: * : ..*::..: . *. * : *:*. . *::*: ***.. * **:.. * : : :.:. :..* : *: :. *:. . :***::*: :** :: ... *:* *: . :***:.*:.*:******.* :*:..**. . *** : :. : . . * .*: **:.:: :: * * *.. *.: *****:.. ***** * * :** *:*** ::****.***:*** **.*: ", "identical_positions": 213, "similar_positions": 278, "identity": "13.99%" }, { "cls_id": "homologset.agr.HGNC:17493", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "O88513-1", "uniprot_id": "GEMI_MOUSE", "id": "O88513-1", "name": "Geminin", "aln": "MNLSMKQKQEGAQENVKNSPVPRRTLKMIQPSADGSLVGRENELPKGLFKRKLWDDQLASQTSSCG---PEANENKDVGDLTQEAFDLISKENPSSQYWKEVAEQRRKALYEALKENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEEEAVEYSELEDSGAGTCAEETVSSSTDARPCT", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "O75496-1", "uniprot_id": "GEMI_HUMAN", "id": "O75496-1", "name": "Geminin", "aln": "MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEETVEDSLVEDSEIGTCAEGTVSSSTDAKPCI", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "D3ZWJ0-1", "uniprot_id": "D3ZWJ0_RAT", "id": "D3ZWJ0-1", "name": "", "aln": "MNLSMKQKQEGAQENVKSSPVPRRTLKMIQPSAAGSLVGRENELPKGLSKRKLWDDQLTSKISSCG---PEANENNSVGDLTQEACDLMTKENPSSQYWKEVAEQRRKALYEALTENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIEIY--------------LFYAHMFTVAVFRHTRRRFWIWIPLQMVVSHHVVAGI", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "** ******* :**:*.*.************* **********. ** *** :*:*:* ** * **:.**:.:*.:***: **: **************:*********.*************.*****:****:*************:** * :. :* : * .. . ", "identical_positions": 120, "similar_positions": 30, "identity": "57.42%" }, { "cls_id": "homologset.agr.HGNC:17494", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q8BQU6-1", "uniprot_id": "CXG2_MOUSE", "id": "Q8BQU6-1", "name": "Gap junction gamma-2 protein", "aln": "MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGTRRLPRAQLPPPPPGWPDTTDLGEAEPILAL-EEDEDEEPGAPEGPGEDTEEERAEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPTPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCAGLNATSRGAPRVGGLASGTGSATSGGTVGEQSRPGAQEQLATKPRAGSEKGSTGSRDGKATVWI", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q80XF7-1", "uniprot_id": "CXG2_RAT", "id": "Q80XF7-1", "name": "Gap junction gamma-2 protein", "aln": "MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQLPPPPPGWPDTTDLGEAEPILAL-EEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRGPPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5T442-1", "uniprot_id": "CXG2_HUMAN", "id": "Q5T442-1", "name": "Gap junction gamma-2 protein", "aln": "MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDR--DRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "********************************************:******:*******************************************************************.** ***:**** .***:.:**** **:*.* **:*:**.**.**.**::** :*:..:*. *.***:. ****:***********************.******************** ***.***********************************************************..*:.*.*:***************************************************.. ****.** ** *:***.**.*. ** ******.******.*.*::*: .:***.******:.*****:****", "identical_positions": 369, "similar_positions": 54, "identity": "83.67%" }, { "cls_id": "homologset.agr.HGNC:17495", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q921C1-1", "uniprot_id": "CXG3_MOUSE", "id": "Q921C1-1", "name": "Gap junction gamma-3 protein", "aln": "MLLLELPIKCRMCGRFLRQLLAQESQHSTPVGRFLLPMLMGFRLLILVSSGPGVFGNDENEFICHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIYVAFTLYHVIGYWEVPGKENKEQETQISKGDHSKDVSGAKSLKLLWAYVAHLGVRLALEGAALGVQYNLYGFKMSSTFICREDPCIGSTTCFQSHPSEKTIFLNIMFGISGACFLFIFLELALLGLGRFWRIYKHKLSFLKKLPTSESSVRSKDTTDELSVVEAKEPF----------------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "F1LPT0-1", "uniprot_id": "F1LPT0_RAT", "id": "F1LPT0-1", "name": "Gap junction protein", "aln": "-----------MCCSFLRQLLARESQHSTPVGRFLLPVLVGFRLLILVSSGPGVFGNDENEFMCHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIYVAFTLYHVIGYWEVPGR-NKEQEAQICKGGRCKDVSGAMSLKLLWAYVAHLGVRLVLEGAALGVQYHLYGFKMPSTFICREDPCIGSTTCFQSHPSEKTILLNTMFGISGACLLFIFLELVLLGLGRVWKTYRHKLPLFKNLSTSERSVRHKDTTDDLSVVETKEPF----------------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8NFK1-1", "uniprot_id": "CXG3_HUMAN", "id": "Q8NFK1-1", "name": "Gap junction gamma-3 protein", "aln": "-----------MCGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIWHWELSGK-GKEEETLIQGREGNTDVPGAGSLRLLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGLGRWWRTWKHKSSSSKYFLTSESTRRHKKATDSLPVVETKEQFQEAVPGRSLAQEKQRPVGPRDA", "tax_id": 9606, "tax_name": "Human" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " ** ***:***.**::******:***:*:****::*.:*****:*:::.**:** *****: *:*.*:********.*****:*****:*:.******* :**:.*: .**:*: * .**.** **:*******:**.**.*******:**:****:*.*:* **.:**:** ** *:******:*: ***:** *:** ****.****** *: ::** . * : *** : * *.:**.*.***:** * ", "identical_positions": 161, "similar_positions": 64, "identity": "55.33%" }, { "cls_id": "homologset.agr.HGNC:17496", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5XIG5-1", "uniprot_id": "GKAP1_RAT", "id": "Q5XIG5-1", "name": "G kinase-anchoring protein 1", "aln": "MASAVLSSVLTTASRFALLQVDSGSGSDSEPGK--GKGRNNGKSQT----LGNKSTANEKKREKRRKKKEQQQSEANELRNLAFKKIPQKS----SHSVCNVQHELSLPNPVQKESR-EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHRQDYENAENASTQTKVINKKDKRKNHQGKDKPLTVSLKDFQCEDHISKKTEESNSSQPLSHDGGFFNRLEDDVHKILVREKRREQLTEHNGTDNCPAPEHNQEVGLKDGRIERLKLELERKDAEIQKLKAVVTQWEAKYKEVKARNGQLLKMLQEGEMKDKAEILLQVDESQSIKNELTVQVSSLHAALEQERSKVKVLQAELAKYQGGRKGKRNCEPDQCR", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9JMB0-1", "uniprot_id": "GKAP1_MOUSE", "id": "Q9JMB0-1", "name": "G kinase-anchoring protein 1", "aln": "MASAVLSSVLTTASRFALLQVDSGSGSDSEPGK--GKGRSNGKSQT----LGNKATSNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKS----SHSICNVQHELSSPNPAQKESR-EENWQEWRQKDEQLTSEMFEADLEKALLLSKLEYEEHKQDYENAETASTQTKGINKKDKRKNHQGKDKPVTVSLKDFQCEDHISKKAEESNSAQTLSHDGGFFNRLEDDVHKILIREKRREQLTEHNGTDNSPAPEHNQEVGLKDGRIERLKLELERKDAEIQKLKAVITQWEAKYKEVKARNGQLLKMLQEGEMKDKAEILLQVDESQSIKNELTVQVSSLHAALEQERSKVKVLQAELAKYQGGRKGKRNFEPDHCR", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q5VSY0-1", "uniprot_id": "GKAP1_HUMAN", "id": "Q5VSY0-1", "name": "G kinase-anchoring protein 1", "aln": "MASAVLSSVPTTASRFALLQVDSGSGSDSEPGK--GKGRNTGKSQT----LGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKS----SHAVCNAQHDLPLSNPVQKDSR-EENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEELSSSQTLSHDGGFFNRLEDDVHKILIREKRREQLTEYNGTDNCTAHEHNQEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESDQCR", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6NWC9-1", "uniprot_id": "GKAP1_DANRE", "id": "Q6NWC9-1", "name": "G kinase-anchoring protein 1", "aln": "MASAVIS-VPTTASRFALLQVDSDSDSDSDVGKPKAAGRGAGKPRSGKSPSGKNSQNNEKKKEKRRRKKEQQQSEANELRSLAFKKIPQKSTAPPSLTLQDLANDLINPANVQQGSKPQENWQEWKQRDEQLTSDLYEADLEKALMLSKLEFEEHKKDADKAETASPKTKTGGKKDRKKNQQGKDKRVTVSLKDFQQEDQLKNKPEREPVNPALRDDK-FFNKLEDDVSKIVQRDKRREQYSNSAGQEVNTSSEHEQDV-----RTEQLKYELEKKDQEIAKLKKTISQWEERYKEVKARNSQLLKMLQQGEMKDKAEILLQVEELLNIKEELSSQVTQLHTALEQERSKVKGLQSEQPKHQGNRKGKKASEGDV--", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "*****:* * *************.*.***: ** . **. **.:: *.:: ****:****:*************.********** * :: : ::* . .*: *: :******:*:******:::********:*****:***::: :.**.:*.::* .***::**:****: :*******: **::.:*.*. .* .* ***:***** **: *:***** :: * : .: **:*:* * *:** ***:** ** *** .::*** :********.*******:*************:* .**:**: **:.**:********** **:* .*:**.****: * * ", "identical_positions": 218, "similar_positions": 87, "identity": "57.82%" }, { "cls_id": "homologset.agr.HGNC:17497", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q5PQN7-1", "uniprot_id": "LZIC_RAT", "id": "Q5PQN7-1", "name": "Protein LZIC", "aln": "MASRGKTETSKLKQNLEEQLDRLMQQLQDLEECREELDGDEYEETKKETLEQLSEFNDSLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRTRLAEMDRDLMVGKLERDLHTQQKVEILTALRKLGEKLTDDDEAFLSANAGAVLSQFEKVSTELGSGDKVLALAGFEVEKAKK", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q8K3C3-1", "uniprot_id": "LZIC_MOUSE", "id": "Q8K3C3-1", "name": "Protein LZIC", "aln": "MASRGKTETSKLKQNLEEQLDRLMQQLQDLEECREELDADEYEETKKETLEQLSEFNDSLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRTRLAEMDRDLMVGKLERELYTQRKVEILTALRKLGEKLTEDDETFLSANASAVLSQFEKVSTELGSGDKVLALAGFDVEKAKK", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q8WZA0-1", "uniprot_id": "LZIC_HUMAN", "id": "Q8WZA0-1", "name": "Protein LZIC", "aln": "MASRGKTETSKLKQNLEEQLDRLMQQLQDLEECREELDTDEYEETKKETLEQLSEFNDSLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRTRLAEMDRDLMVGKLERDLYTQQKVEILTALRKLGEKLTADDEAFLSANAGAILSQFEKVSTDLGSGDKILALASFEVEKTKK", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q6DHH7-1", "uniprot_id": "LZIC_DANRE", "id": "Q6DHH7-1", "name": "Protein LZIC", "aln": "MASRGKSETSKLRQNMEEQLDRLMQQLQDLEECREDLEEEEYEETKKETLEQLSEFNDSLKKLMSGNMTLVDELGGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRTRLAEMDRDVMVGKLSRDVFTQQKVEILTALRKLGEKLTTEDEAFLAANASATLSHFEKVTASLGSEDKIMALASSGVGKTQT", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******:*****:**:*******************:*: :**********************:***********.*****************************************:*****.*::.**:**************** :**:**:***.* **:****::.*** **::***. * *::.", "identical_positions": 155, "similar_positions": 28, "identity": "81.58%" }, { "cls_id": "homologset.agr.HGNC:17499", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9UGK8-1", "uniprot_id": "SRGEF_HUMAN", "id": "Q9UGK8-1", "name": "Secretion-regulating guanine nucleotide exchange factor", "aln": "MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQ--LNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIP---YFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHG-PRRCVVPQAIELHK-EKVVCIAAGLRHAVAATASGIVFQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTE-TGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHN-LAIIGGVCYSWGWNEHGMCGDG------------TEANVWAPKPVQALLSSSG--LLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPDAIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL--------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q80YD6-1", "uniprot_id": "SRGEF_MOUSE", "id": "Q80YD6-1", "name": "Secretion-regulating guanine nucleotide exchange factor", "aln": "MARESCASETVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQ--LSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVL---RFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHG-PRKCVVPQAIECLR-EKVVCVAAGLRHALATTATGSVFQWG-TGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTE-TGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGATEISCGSEHN-LAVIRDKCCSWGWNEHGMCGDG------------TESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVCQLPAHPVPCQDLKVTCPLPDDTENTESQGAVDRDR----LEGETISDLNPDRTRNGGGGCESETVQ", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "A0ACD6B687-1", "uniprot_id": "A0ACD6B687_DANRE", "id": "A0ACD6B687-1", "name": "", "aln": "MEGD----QLSKCVSLLYTWGANSYGQLGQGNAEDQAEPRR--VESGLQEEQIRAVTGGGGHSALISDSGELLVCGQNHKGQLGLGHTLEIM---TFQTCPLPGFGRVQQVSCGWDFTIILTGDGLVLACGSNAFGQLGVSAE-KTHSAEPLLLKSFH-EPVSSVAAGLRHALASTASGCVYQWG-TGLSSHAKRMLNPQPVPSHLSSKEPCLVPGFAHVTTQKVIAGSAHCACLTVNGDVFLWGSNKHGQLISGSLFLPLPVALDRSMLQDERVSDVHSGWTHLIAQTE-SGRVFTWGRSNYGQLG---QTDHSMEKQSSDEHLVRS------PVEVKALFGATQISCGSEHN-LAVVGGRVFSWGWNEHGMCGDG------------SLQDITQPQPIPALADAVA--LLIGCGAGHSMALCSLKSS-----------------EDSAR---------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "M9PAZ8-1", "uniprot_id": "M9PAZ8_DROME", "id": "M9PAZ8-1", "name": "RCC1-like domain-containing protein", "aln": "--------------MEVYAWGANSHGQLGLGFESELCMTPQRVAKCSFAPAQVRLIRGGGGHVLILDTSGRIHACGWNNRGQLGLDSTEECHSEFKMIPTEYFGDVPVETISCGWDISGAITLTKRLFVWGSNAFQQLGICQRGFTAVRRPMPVKLPREEPAQRISFGLRHCAVLTQDNKIYVFGRLRIMDPPPIELDITATCLHRCNTVKIQVHNPNELRIVSISSGQNHMVLKCADLSETGGGSTKRILTLGDNKFG-----QSNAFQFEEDVRQLAVGWTHNAAVLK-NNEILVWGRNCYGQLGMGSFSEQQAIPTPLRLKLPED-------------QGPARIHMGAEHGLLRTTAGEVYTWGWNEHGNCGNN------------STENLHPNSFTTATSEIVRRRSRILLRDHRARNLTLSPCDVLLV---------------------------------------------------------", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "P31386-1", "uniprot_id": "ATS1_YEAST", "id": "P31386-1", "name": "Protein KTI13", "aln": "-------------MSCVYAFGSNGQRQLGLGHDEDMDTPQR--SVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRRGELDSAQALRQVH--DWRPVEVP--APVVDVACGWDTTVIVDADGRVWQRGGGCYEFT--------QQHVPLNSNDER-----IAVYGCFQNFVVVQGTRVYGWG-----SNTKCQLQE---PKSRSLKEPVLVYDTGSVAVDYVAMGKDFMVIVDEGGRIVHAS----GRLPTG---------FELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQLFPQERLDFPIVGVATG-------------------SEHGILTTANQEG--KSHCYNVYCWGWGEHGNCGPQ------------KGS-----QPGLQLVGQYSGKPRVFGGCATTWIVL------------------------------------------------------------------", "tax_id": 559292, "tax_name": "Baker's yeast" }, { "uniprot_ac": "P09810-1", "uniprot_id": "TPH1_RAT", "id": "P09810-1", "name": "Tryptophan 5-hydroxylase 1", "aln": "----------MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWG-TIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFG-LCKQDGQLRVFGAGLLSSISELR--HALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV--------------------------------", "tax_id": 10116, "tax_name": "Rat" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " :. :: . :. : . : : . :*. . : . : . * : :* . . . . . . * : : :. : * . : ", "identical_positions": 5, "similar_positions": 34, "identity": "1.02%" }, { "cls_id": "homologset.agr.HGNC:175", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "P80203-1", "uniprot_id": "ACVL1_RAT", "id": "P80203-1", "name": "Activin receptor type-1-like", "aln": "-----------------------------------MTLGIFR------RVFLMLS--VALGLTKGDLVKPSRGQ----LVNCT--CENP-HCKRPICQGAWCTVVLVREQGRHPQVYRGCGSLNQELCLGRP--------------TEFVNHHCCYRSFCNHN---VSLMLEATQTPSEEPEVDAHLPLILGPVLALLVLVALGTLGLWRVRRRQEKQRGLHSDLGE------SSLILKASEQGDSMLGDFLVSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSQNP----EKPKVIH-----", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q61288-1", "uniprot_id": "ACVL1_MOUSE", "id": "Q61288-1", "name": "Activin receptor type-1-like", "aln": "-----------------------------------MTLGSFR------RGLLMLS--VAFGLTRGDLAKPSK------LVNCT--CESP-HCKRPFCQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRP--------------TEFLNHHCCYRSFCNHN---VSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGE------SSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNP----EKPKVIH-----", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P37023-1", "uniprot_id": "ACVL1_HUMAN", "id": "P37023-1", "name": "Activin receptor type-1-like", "aln": "-----------------------------------MTLGSPR------KGLLMLL--MAL-VTQGDPVKPSRGP----LVTCT--CESP-HCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRP--------------TEFVNHYCCDSHLCNHN---VSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGE------SSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSP----EKPKVIQ-----", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9P4Z5-1", "uniprot_id": "A0A8M9P4Z5_DANRE", "id": "A0A8M9P4Z5-1", "name": "receptor protein serine/threonine kinase", "aln": "--------------------------------MRDMKASVML------AVLFVLVYSGSYATTADHLMETSTLKNDESSLQCS--CENTNLCENNSCWGRICFYTSVHER-----VVRGC-FQTAEQCYVPA--------------IPGVYTKCCYTHHCNAN---LTMPEKPVCLFSVEKPIR--VILLVGVPLLVLLVIAMAACGLVLWLR---TRRQYCHPVEH------DTSMLKVPSGGDPTYGDIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYLDVGTNPRVGTKRYMAPEVLDETIRVDVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSLSKLDQDHDYDIDKLKLDL-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "A0A0B4K7J3-1", "uniprot_id": "A0A0B4K7J3_DROME", "id": "A0A0B4K7J3-1", "name": "receptor protein serine/threonine kinase", "aln": "MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASAD----EKIRLDFDEVCV", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " * . : : . . . * *... . * .:: *** : . : ** ** . : .. :::. . : :.. : * .: . . :*:... .*. : : *:***:*** *****:*:*::*:**:*:*:******* * ***:***** ****:** ******.*: ***:******.*****:**.*****:**:: ***:*.*: .:*. . : :.:* * **.***.**:..*****:****:**:*:**. * .* ***:**** **: :. **:*.**:************** * : **: : ***:*:******: **** **.*:*: **:*:** *****:*:****:*: *:: ** :..:::.::::*:***. .*..**.***::*:: *: :* :: ", "identical_positions": 197, "similar_positions": 135, "identity": "33.62%" }, { "cls_id": "homologset.agr.HGNC:1750", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1MAH6-1", "uniprot_id": "F1MAH6_RAT", "id": "F1MAH6-1", "name": "", "aln": "-MKENYCLQAALVCLSMLYHSQAFALERRSHLRPSFHGHHEKGKEGQVLQRSKRG----WVWNQFFVIEEYTGPDPVLVG-----------RLHSDIDSGDGNIKYILSGEGAG------------------TIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTN--RPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQ--PYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMG---------------------------------------------------------------------------------GHMG-----------------------------GLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPD-IGENGLVTYNIVDG-----------------------------------------------------------------------------------DGMELFEITTDYET----------------------QDGVVKLKKPVDFETKRAYSLKVEAAN--------VHIDPKFISNGP--FKDTVTVKIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPD-------------------------------------------------------------------------------------------AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQEAKVPVAIRVLDVNDNAP------KFAAPYEGFICESDHPKPLSNQP----------------------------------------------------------------IVTVSADDLDDTANGPRFIFSLPPEIIHNPN-------------------------------FTVRDNR------------------DNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLT----------------------------------------------------------------------------------IKVCG--------------------------------------------------------------------------------------------CDVNGALLSCN-------------------------------------------------------------------AEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS---------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "P55288-1", "uniprot_id": "CAD11_MOUSE", "id": "P55288-1", "name": "Cadherin-11", "aln": "-MKENYCLQAALVCLSMLYHSQAFALERRSHLHPSFHGHHEKGKEGQVLQRSKRG----WVWNQFFVIEEYTGPDPVLVG-----------RLHSDIDSGDGNIKYILSGEGAG------------------TIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTN--RPLEPPSEFIVKVQDINDNPPEFLHEIYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQ--PYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMG---------------------------------------------------------------------------------GHMG-----------------------------GLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPD-IGENGLVTYNIVDG-----------------------------------------------------------------------------------DGIELFEITTDYET----------------------QDGVVKLKKPVDFETKRAYSLKIEAAN--------VHIDPKFISNGP--FKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPD-------------------------------------------------------------------------------------------AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQETKVPVAIRVLDVNDNAP------KFAAPYEGFICESDHPKALSNQP----------------------------------------------------------------IVTVSADDQDDTANGPRFIFSLPPEIMHNPN-------------------------------FTVRDNR------------------DNTAGVYARRGGFSRQKQDFYLLPIVISDGGIPPMSSTNTLT----------------------------------------------------------------------------------IKVCG--------------------------------------------------------------------------------------------CDVNGALLSCN-------------------------------------------------------------------AEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS---------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P55287-1", "uniprot_id": "CAD11_HUMAN", "id": "P55287-1", "name": "Cadherin-11", "aln": "-MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRG----WVWNQFFVIEEYTGPDPVLVG-----------RLHSDIDSGDGNIKYILSGEGAG------------------TIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTN--RPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQ--PYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMG---------------------------------------------------------------------------------GHMG-----------------------------GLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPD-IGENGLVTYNIVDG-----------------------------------------------------------------------------------DGMESFEITTDYET----------------------QEGVIKLKKPVDFETKRAYSLKVEAAN--------VHIDPKFISNGP--FKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPD-------------------------------------------------------------------------------------------AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAP------KFAAPYEGFICESDQTKPLSNQP----------------------------------------------------------------IVTISADDKDDTANGPRFIFSLPPEIIHNPN-------------------------------FTVRDNR------------------DNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLT----------------------------------------------------------------------------------IKVCG--------------------------------------------------------------------------------------------CDVNGALLSCN-------------------------------------------------------------------AEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS---------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q24298-1", "uniprot_id": "CADE_DROME", "id": "Q24298-1", "name": "DE-cadherin", "aln": "MSTSVQRMSRSYHCINMSATPQAGHLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDD---GNNSLVEYEILRERDFQYFKIDKESGIIYLKRP-IDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIP-YYTEVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNG-WHEKDIDDIRETIINYEDEGGGERDTD-YDLNVLRTQP----FYEEKLYKDPHALQG--NMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQGWRI", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " .. :. : *:.* .:* : : . * :: :. ::: : .: :: ** : * ..:.. : : .*:*: *... . *.*: .:* *.:*:*:**:* : .:: :*: * **: . * *.::*****.* * : *. .:.*.:: .: *: ::*** ** **.: : *.**. : **.:: ::*** * :*:.. :.* ::::* :: .::* *. ::.* : ***** * : .* . :: * ** * :*:* * * . *.:*::::.*. . * :*:.:: * : * :.::: :*:** *.**:.* : * *. : :.:.* **: :*.* * : : :: . :* ::::. * :* :* :* : .. . : :.** .: * .:. :..::::. :*** *.: :: :*.: : : : ****** * *:* *:* : : :: :* .:: *.:.. *** *:: *. *** :*. :: *: *:. .:: *: :* : *.: * :.. :: * * .*. *:. ** :. * : * :. *:. . :***:.*:.:**:*:: .*. ::**: : :*:**.**.*:******.**: :*: .*:. * .* * : .:* . : *: **:. : ::.*.* *.. *.:: *.*** *. ****** *.* *.**::***.*:****:****:**.: : *.. ", "identical_positions": 212, "similar_positions": 302, "identity": "13.95%" }, { "cls_id": "homologset.agr.HGNC:17500", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9R064-1", "uniprot_id": "GORS2_RAT", "id": "Q9R064-1", "name": "Golgi reassembly-stacking protein 2", "aln": "MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSISGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEE-GKKISLPGQMTGTPITPLKDG----FTQVQLSSVSPPSLS--PPGTAGVEQSLSGLSISSAPPAVSNVLST----GVPTVPLLPPQVNQSLASVPPMNPAATLPSLMPLSAGLPNLPNLPSLSNFNLPAPHIMPGVGLPELGKPGLPPLPSLPPRNVPGIAPLPMPSDFLPSFPLVPEGSSAASAGEPLSSLPAMG--PPSDPVMTTAKADTSS-LTVDVMSPASKVPTTVEDRVSDCTPAMEKPVSAVTDANASGAS", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q99JX3-1", "uniprot_id": "GORS2_MOUSE", "id": "Q99JX3-1", "name": "Golgi reassembly-stacking protein 2", "aln": "MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEE-GKKISLPGQMTGTPITPLKDG----FTEVQLSSVSPPSLS--PPGTTGVEQSLSGLSISSAPPAVSNVLST----GVPTVPLLPPQVNQSLASMPPMNPATTLPSLMPLSAGLPSLPNLPSLSNFNLPAPHIMPGVGLPELGSPGLPPLPSLPPRNLPGIAPLPMLSDFLPSFPLVPEGSSAASAGEPLSSLPAMG--PPSDPVMTTAKADASS-LTVDVTSPASKVPTTVEDRVSDCTPAVEKPVS---DADASEPS", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9H8Y8-1", "uniprot_id": "GORS2_HUMAN", "id": "Q9H8Y8-1", "name": "Golgi reassembly-stacking protein 2", "aln": "MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEE-GKKISLPGQMAGTPITPLKDG----FTEVQLSSVNPPSLS--PPGTTGIEQSLTGLSISSTPPAVSSVLST----GVPTVPLLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNL----NLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASSGELLSSLPPTSN-APSDPATTTAKADAASSLTVDVTPPTAKAPTTVEDRVGDSTPVSEKPVSAAVDANASESP", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "Q9VW57-1", "uniprot_id": "Q9VW57_DROME", "id": "Q9VW57-1", "name": "", "aln": "MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDKPVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLRAYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIGFGYLHRIPVQAEPVTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPAP--PAVADVSVAQPQVQVPAPAQPLPPPANIFIPGVFDPST-QQNANALGGIPAAQLP----FPQATAAPAAVPMFSAPQQAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTPLPPQMAHVFAPPVPPQAGAAPAAGNDELSGPAVNQAGN-", "tax_id": 7227, "tax_name": "Fruit fly" }, { "uniprot_ac": "Q04410-1", "uniprot_id": "GRH1_YEAST", "id": "Q04410-1", "name": "GRASP65 homolog protein 1", "aln": "MFRIAKNLVRTFEQSVQDTLALSQDS----SNLDAFFQSIP--------------PNLLSAQLESPVDAVSEGVKHTNVNETLSGLRIVWVDEMQFQLQSFFDYIVGFNDDPVPVVSNQHG--------FSYPDYRR-----------ITSIFNEHCGRTLKVNIWSAKGGTFRDEYISIISKESDD---LDDVSLNHDERRPSSGEAHQFQALGFKVQWTPLIASTFTYH----ILNVNIPDGPAQSAG-LIPDEDYIIGCQDGLLATGGETLLQDIVRS-----RANYDLVLYVYNKVSDCVRPITVHIGPDGRLGCNVGYGFLHRIPTVKHCPQQAQQQGQ--------------------------------DDNPVPVPVPVESETAFVPSAFT---------APPVPTKKKSKNKKGT-----QPLAMDDYFNEGRDKSSTAAKSAESDILAPPPQKQSSSD", "tax_id": 559292, "tax_name": "Baker's yeast" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "* . : . ..* :.::* :.*:.**: * :** :::.** . * :.* * .: : :. * : * *:. ::. . . .:.** : :::: * :.**: ::. . . *: *. : ..: .:. .: .* * . .. : :.: .::.. . : * . : . . ..:. : .. * .: . . .. : * ..*: . * .. *. * : . . . .: . . : ", "identical_positions": 33, "similar_positions": 111, "identity": "7.05%" }, { "cls_id": "homologset.agr.HGNC:17509", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q6AZ54-1", "uniprot_id": "HEMGN_RAT", "id": "Q6AZ54-1", "name": "Hemogen", "aln": "MDVRKDQSHLTLNQTPEAHVEKSHAPDIIGSWSLRNREQLKKRKAEAQGRQTSQWQLGEQKKRKYQRTGKGNRRGRKRQGNVEQKAESWSQ-TENERVQEVLVPAEEETEYSGNTATQALPLRASPTKAVPTEHCSEVPQESLQCQEITIQNHSQTHQRRDKAEALSPTTCQEIGVLQYSPKMCQDMAEPEARSPKMCQETAVPQTYSPKAHEDMAEYEALSPKMCRETPVPQYHSSKIPQDMTGPEALAPDMCQETTVSQNHSSKVPQDMAGPEALSLKMCQEPTVLQEHTLKICQDVARPDVLSSKTHQEMTVPKALPCITPGDAAGPEGCSPKTLPQS--------DVTPMSVTPGKNTSHPDLGTAVAEGCFSEAGECIVSEDISTKTHQEAVEPKFLSHKTYKEFTVPIVSSHKTIQESPGPEEYSPG--------------SRHEMS----------------------------GPEDLSIKTCKNRDGPKHSLPEGAQEVGGAQRQDPDAQDIEDAGAFSQD---LEEGNKADQDPETPAGPQGPQKICPENDVHSSALF", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9ERZ0-1", "uniprot_id": "HEMGN_MOUSE", "id": "Q9ERZ0-1", "name": "Hemogen", "aln": "MDMGKGRPRLKLPQMPEAHPQKSCAPDIIGSWSLRNREQLRKRKAEAQGRQTSQWLLGEQKKRKYQRTGKGNKRGRKRQGNVEQKAEPWSQ-TERERVQEVLVSAEEETEHPGNSATEALPLVPSPTKAVPADQCSEAHQESIQCQERAIQNHSQTH--------LSPTTCQGIAVLQHSPKMCQDMAEPEVFSPNMCQETAVPQTYPPKALEEMAAAEPLSPKMC----------------------------QETTVSPNHSSKVPQDMAGPEALSPNMCQEPTVPQEHTLKMCHDVARPEVLSPKTHQEMAVPKAFPCVTPGDAAGLEGCAPKALPQSDVAEGCPLDTTPTSVTPEQTTSDPDLGMAVTEGFFSEARECTVSEGVSTKTHQEAVEPEFISHETYKEFTVPIVSSQKTIQESPEPEQYSPETCQPIPGPENYSLETCHEMS----------------------------GPEDLSIKTCQDREEPKHSLPEGAQKVGGAQGQDADAQDSENAGAFSQDFTEMEEENKADQDPEAPASPQGSQETCPENGIYSSALF", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q9BXL5-1", "uniprot_id": "HEMGN_HUMAN", "id": "Q9BXL5-1", "name": "Hemogen", "aln": "MDLGKDQSHLKHHQTPDPHQEENHSPEVIGTWSLRNRELLRKRKAEVHEKETSQWLFGEQKKRKQQRTGKGNRRGRKRQQNTELKVEPQPQ-IEKEIVEKALAPIEKKTEPPG-SITKVFPSVASPQKVVPEEHFSEICQESNIYQEN-------------------FSEYQEIAVQNHSSETCQHVSEPEDLSPKMYQEISVLQ--------------------------------------------------------DNSSKICQDMKEPEDNSPNTCQVISVIQDHPFKMYQDMAKREDLAPKMCQEAAVPKILPCPTSEDTADLAGCSLQAYPKPDVPKGYILDTDQNPAEPEEYN-ETDQGIAETEGLFPKIQEIAEPKDLSTKTHQESAEPKYLPHKTCNEIIVPKAPSHKTIQETPHSEDYSIEINQETPGSEKYSPETYQEIPGLEEYSPEIYQETSQLEEYSPEIYQETPGPEDLSTETYKNKDVPKECFPEPHQETGGPQGQDPKAHQEDAKDAYTFP---QEMKEKPKEEPGIPAILN---ESHPENDVYSYVLF", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0ACD6B6Y2-1", "uniprot_id": "A0ACD6B6Y2_DANRE", "id": "A0ACD6B6Y2-1", "name": "", "aln": "------MEDPLEKEIPPTEIKDSDEGGIR--RRLRDRDLLKKRKAEAEEKATNQWVYGAQSIKRVKKRTTTGTPGRKGRPRKEPIVIAEDLGLAQEVDPSPITIPVTEPELPTIAEIEPLQPVEPQQELVPEEAISEKPQE-------------------------------EFLIEDLGPDEEEDMPQ---------------------------------------------------------------------------KNLVIDTGDDE------------------KPYNDVPEQ--------SSIAIPMFAPAPDSSQPDNLSLTENLLF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------", "tax_id": 7955, "tax_name": "Zebrafish" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : * .. :.. : **:*: *:*****.. : *.** * *. :: :: . . *** : . * . . .* . :. :.* . : : : . : ** : ** ** : : : ... :.:.: .:: * * * :*:.. .. ::* *. . :. . ", "identical_positions": 33, "similar_positions": 65, "identity": "5.81%" }, { "cls_id": "homologset.agr.HGNC:1751", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "F1M1A2-1", "uniprot_id": "F1M1A2_RAT", "id": "F1M1A2-1", "name": "Cadherin-12", "aln": "------MLTRNSLYLLLWILFDGGLLTPLQPQPQQT----------------------LATEPK-DNVIHLLGRRSHFQRVKRGWVWN---QFFVLEEYMGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG-TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETR--KPLEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ--PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMG---------------------------------------------------------------------------------GQLG-----------------------------GLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIVTDEDTQEGIIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVD--EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNPSLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVGAVDRDLS-------------------------------------------------PAGQQFSFRLAPEAVIKPNFTVHDFRN-----------------NTAGIETRRN---------------------------------------GYSRRQQELYFLPIVIEDSSYPVQSSTNTMTIRVCRCDSDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILSCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSFCLPRQRPQVEDNTDIRDFIHQRLQENDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTSEADQDYDYLSDWGPRFKVLADMFGEEESYNPDNVT-------------", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q5RJH3-1", "uniprot_id": "CAD12_MOUSE", "id": "Q5RJH3-1", "name": "Cadherin-12", "aln": "------MLTRNSLYLLLWILFDGGLLTPLQPQPQQT----------------------LATEPK-ENVIHLSGRRSHFQRVKRGWVWN---QFFVLEEYMGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG-TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETR--KPLEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ--PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMG---------------------------------------------------------------------------------GQLG-----------------------------GLAGTTVVNITLTDVNDNPPRFPKSIFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIVTDEDTQEGIIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVD--EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGESYFTIDGTEGTIATNELLDRENMAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVGAVDRDLS-------------------------------------------------PAGQQFSFRLAPEAVIKPNFTVHDFRN-----------------NTAGIETRRN---------------------------------------GYSRRQQELYFLPIVIEDSSYPVQSSTNTMTIRVCRCDSDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILSCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEAIFLPVGLSTGALIAILLCMVILLAIVVLYVALRRQRKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLSRQRPQVEDNTDIRDFIHRRLQENDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTTEADQDYDYLSDWGPRFKVLADMFGEEESYNPDNVT-------------", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "P55289-1", "uniprot_id": "CAD12_HUMAN", "id": "P55289-1", "name": "Cadherin-12", "aln": "------MLTRNCLSLLLWVLFDGGLLTPLQPQPQQT----------------------LATEPR-ENVIHLPGQRSHFQRVKRGWVWN---QFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG-TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETR--KPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ--PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMG---------------------------------------------------------------------------------GQLG-----------------------------GLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVD--EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLS-------------------------------------------------PAGQQFSFRLSPEAAIKPNFTVRDFRN-----------------NTAGIETRRN---------------------------------------GYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILSCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT-------------", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A8M9Q975-1", "uniprot_id": "A0A8M9Q975_DANRE", "id": "A0A8M9Q975-1", "name": "Cadherin-12", "aln": "------MLRRNCLLLFLCFLFEQSSCTPFQSRPGQE----------------------WPHSPTGPSAAGRNGGSRGFQRVKRGWVWN---QFFVLEEYMGSDPQYVGKLHTDLDKGDSAVKYTLSGDGAG-TIFTIDQTTGDIHALRSLDREEKPYYTLRAQAVDIDTN--RPLEPESEFVIKVQDINDNEPKFLEGPYTASVPEMSPVGTYVMKVTATDADDPTYGNSARVVYSILHGQ--PYFSVDPKTGVIRTALPNMDREVKELYQVLIQAKDMG---------------------------------------------------------------------------------GQLG-----------------------------GLAGTTTINITLSDVNDNPPRFSKSIFHLRVPESSAVGSAVGRIKAHDLDIGKNAEVEYNIVPGDGGAMFDITTNEHNQEGIIMLKKPLDYETKKAYTFKVEASNAHLDPRFHSFGPFKDTATVKINVLDVD--EPPVFSKPSYAMDVYEDTPQGTIIGAVTAQDLDAGNSPVRYSIDWKSDLDSFFDIDPVRGTISTNELLDRESIAQHNISVVATKVNNPVLTSRVAVSVHVLDINEFPPELAMPYETFVCETAKIGQVIQIISAKDEDLP-------------------------------------------------QAGQRFSFRSPQEGVKTKNFTIRDFGN-----------------NTAGVVTLRS---------------------------------------GFKRRSQEIYHLPIVIEDGGLQTLSSTNTLTIRVCGCDTDGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLTCS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEAIFLPVGLSTGALIAILVCIIILLVIVVLYVGVRRQKKKETLMTSKEDIRDNVIHYDDEGGGEEDTHAFDMGTLRNPKVIKENLFRRDVKPELGLCPRRPIGSQNSNDISNFISQRLQEHDGDTSAPPYDSLATYAYEGEGSVAESLSSIESVKGETEEDYDYLNEWGPRFKTLAGIFGERSESQSDVTSSSATENKH-----", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "B0V236-1", "uniprot_id": "B0V236_DANRE", "id": "B0V236-1", "name": "Cadherin-12", "aln": "------MLMGNCLLLFLWCLLEKSFVSSLHSSSQSR----------------------MGKEQHRNLMAHRKHGVMGVHRVKRGWVWN---QFFVLEEYMGSDPQYVGKLHSDMDKGDSMVKYTLSGEGVG-SIFTIEPSTGDIHALRSLDREEKPYYTLRAQAVDMLTG--RPLEPESEFIIKVQDINDNEPRFLEGPYSASVPEMSPVGTYVTQITATDADDPTYGNSARIVYSILHGQ--PYFSVDPKTGVIRVALPNMDREVKETYQVVIQAKDMG---------------------------------------------------------------------------------GQLG-----------------------------GLAGTTTINITLRDVNDNPPRFSKSIFHLRVPESSPVGSSVGRVKAHDLDTGKNAEVEYSILPGDGGSMFDIYSNKDTQEGTVILKKRLDFETRKAYTFKVEASNAVLDHRFLHLGPFKDTAMVKVNVLDVE--EPPVFSRLYYNMETYEDTPVGIIVGAVNAEDLDVSNSPVRYSVEWRKDAENHFAIDPVEGTLSISEALDRERNAEHNVTVVATKVNNPQLSSKVTVTIKVLDVNEFPPELAFVYETFVCENAKAGQVIQILSATDKDVP-------------------------------------------------AVEHRFYFKSSQ--TRNRNFTIRDYGN-----------------NTAGVVTRRG---------------------------------------GFRRLEQSMYLVPVVVEDGGYPIRSSTGTVSVRVCSCDADGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLSCN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEAVFFPMGLSTGALMAILLCIVILLVMVVLYMGLRRHKKKDTLMSSKEDVRDNVIHYDDEGGGEEDTQAFDIGTLRNPKGIKETGPLQKIRSED--KADQASAAEDSEDIRAYIHHCLLES----STPPYDSLVTYAYEGDGSVAESLSSIESWVLEPKEDYRNLCDWGPRFKTLAGIFKEHEGKEKEKVENEAHAEALQDRLD", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q24298-1", "uniprot_id": "CADE_DROME", "id": "Q24298-1", "name": "DE-cadherin", "aln": "MSTSVQRMSRSYHCINMSATPQAGHLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDD---GNNSLVEYEILRERDFQYFKIDKESGIIYLKRP-IDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIP-YYTEVKSGTILENEPPGTPVMQVRAFDMDG-TSANNIVSFELADNREYFTIDPN----TGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDN-ASQILYSIES-GNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDG---IYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQ-KNGWHEKDIDDIRETIINYEDEGGGERD-TDYDLNVLRTQPFYEEK-----LYKDPHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQGWRI------", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": " : . : : : . .. : . . . . :* .:: : : .: ** .:.: . : ::*:: . . * *: :** *.: :::**:* . .: :*: **: . * :.::***** * * .. * ::.* : .: * :.*:* ** **.: : *.**: : **.:* ::*:* * :*:. : * ::::* :: .*:* *. ::* : ***** * : ..: : *... *:.: :::* * * .*: .: .*. * * .: * : . :* * :. *..** **: . * * :. .::.: * : :* . . **: . : *.*:* * * : * :: : . * *. *.:: .: ** * ::::..: * . . . : ::: *:*: ** : *.. : * :. .: * : * * *: . .. . . . ..*::* : *.. : : : * *. * :*: :.*.. *:.. : : : : :. : :*. *: :..*:. . ::**::*: :** ::: : ::: *: .. :*:*:.:*:*:******.* :*:..**. :*. : : . :: ** :: : :.. *.: *****.*. ****: * : . :: * ::****: **.:: *. . . ", "identical_positions": 155, "similar_positions": 276, "identity": "10.1%" }, { "cls_id": "homologset.agr.HGNC:17512", "date": "2026-09-09 05:52:11 EDT-0400", "sequences": [ { "uniprot_ac": "Q9Z214-1", "uniprot_id": "HOME1_RAT", "id": "Q9Z214-1", "name": "Homer protein homolog 1", "aln": "MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQ------ESAGGDLQS---PLTPES------INGTDDERTP-----DVTQNSEPRAEPAQNALPFSHSAGDRTQGLSHASS------------------------------------AISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVH--SHKTELSQTVQELEETLKVKEEEIERLKQEIDNARELQEQR--DSLTQKLQEVE----------------------------------IRNKDLEGQLSELEQRLEKSQS----------------EQDAFRSNLKTLLEILDGKIFELT----------------------------------------------------ELRDNLAKLLECS---", "tax_id": 10116, "tax_name": "Rat" }, { "uniprot_ac": "Q9Z2Y3-1", "uniprot_id": "HOME1_MOUSE", "id": "Q9Z2Y3-1", "name": "Homer protein homolog 1", "aln": "MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQ------ESAGGDLQS---PLTPES------INGTDDERTP-----DVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASS------------------------------------AISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVH--SHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQR--DSLTQKLQEVE----------------------------------IRNKDLEGQLSDLEQRLEKSQN----------------EQEAFRSNLKTLLEILDGKIFELT----------------------------------------------------ELRDNLAKLLECS---", "tax_id": 10090, "tax_name": "Mouse" }, { "uniprot_ac": "Q86YM7-1", "uniprot_id": "HOME1_HUMAN", "id": "Q86YM7-1", "name": "Homer protein homolog 1", "aln": "MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQ------ESAGGDLQS---PLTPES------INGTDDERTP-----DVTQNSEPRAEPTQNALPFSHSS------------------------------------------------AISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVH--THKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQR--DSLTQKLQEVE----------------------------------IRNKDLEGQLSDLEQRLEKSQN----------------EQEAFRNNLKTLLEILDGKIFELT----------------------------------------------------ELRDNLAKLLECS---", "tax_id": 9606, "tax_name": "Human" }, { "uniprot_ac": "A0A0R4INT7-1", "uniprot_id": "A0A0R4INT7_DANRE", "id": "A0A0R4INT7-1", "name": "Homer protein homolog 1", "aln": "MGEQPIYSTRAHVFQIDPSTKKNWMPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMSFTKTSQKFGQWADSRANTVYGLGFSSEHHLAKFADKFAEYKEAARIAKEKSLEKMELASSPSQ------ESP-ADIHS---PLTPPVTADLCRINGTGDDVTLS----DVSPNSMLQSDLSPTTPTLAHSP------------------------------------------------TTNKHWEAELAALKSNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVSELESQSSQTNVIK--SQKTELNQTIEELECTLRAKEEEMMRLKEEVENAKQLQAQK--DELTKKLEDTD----------------------------------MRNKELEEQLSDLEQRLESSQV----------------DQENLRKNLKTLLEILDGKIFELT----------------------------------------------------ELRDNLAKLIEDS---", "tax_id": 7955, "tax_name": "Zebrafish" }, { "uniprot_ac": "Q0E8S7-1", "uniprot_id": "Q0E8S7_DROME", "id": "Q0E8S7-1", "name": "", "aln": "MGEQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNMTFTQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSANTSPISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQPTSGVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCANAKKWEIELATLKNNNIRLTSALQESTANVDEWKRQLHTYKEENIRLKRDMEQLCVGGGVVAAAGGGATEDELRREVATLKARTEQLQKELMQQELELKSANISLREKSNDQTLAKLSEVNGVFAKHLSELYGVQKDMESLIQIAKCTXDTELAFMRKVSVQEQTTMINTTTTSSTTTGSTTSKRYLSNFPTAEAESTLSNVTSIHTQLQSSLYETQNMPQLKALDKHSALLQELHQRQAAPRRNSASAEAAAAGSGGAKTATILVSKSKTKTGLPLLLKNSINN", "tax_id": 7227, "tax_name": "Fruit fly" } ], "algorithm": { "name": "clustalw2", "url": "http://www.clustal.org/clustal2/", "parameter": "Default Clustalw2 parameters" }, "consensus": "******:: :****:***.**:.*:.:* :**.**:****:**:*****::*:**:*********:**:********:* **********:** .*:**.:** * ***:: * :.: . ::.:.* . ..::. .: * * . :: . .: .* ::: : . :. : *:** ***:**.** :**:** ******.:**:** :*:** **:: : :* .. . . : : ** : : *: . ::*: : : *:..*. :: *. **.:.: :*: .:: * : :: .* : : .*:.:: *:..::* : : .*. *:: * ", "identical_positions": 129, "similar_positions": 128, "identity": "24.29%" } ]