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"https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G65092SV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G66538GV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G72735IY", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "Q05320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05320#ptm_processing" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "D", "comment": "Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "618", "end_pos": "618", "site_lbl": "Asn618", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "G08249BH", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G60145BJ", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G68094RR", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "G91344EV", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "35927436", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35927436" }, { "id": "TP3222006", "database": "GlyTableMaker", "url": "https://glygen.ccrc.uga.edu/tablemaker/data/TP3222006" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "Q05320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05320#ptm_processing" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "D", "comment": "Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "108", "end_pos": "108", "site_lbl": "Cys108", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "G", "comment": "Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "111", "end_pos": "111", "site_lbl": "Leu111", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "About 60% loss of ability to counteract host BST2.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "27707924", "url": "https://glygen.org/publication/PubMed/27707924" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "121", "end_pos": "121", "site_lbl": "Cys121", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "G", "comment": "Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "122", "end_pos": "122", "site_lbl": "Leu122", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "About 60% loss of ability to counteract host BST2.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "27707924", "url": "https://glygen.org/publication/PubMed/27707924" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "135", "end_pos": "135", "site_lbl": "Cys135", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "147", "end_pos": "147", "site_lbl": "Cys147", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "170", "end_pos": "170", "site_lbl": "Ile170", "weight": 0.0, "mutagenesis": [ { "sequence_org": "I", "sequence_mut": "A", "comment": "90% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "I", "sequence_mut": "E", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "I", "sequence_mut": "F", "comment": "50% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "511", "end_pos": "511", "site_lbl": "Cys511", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "G", "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "528", "end_pos": "528", "site_lbl": "Gly528", "weight": 0.0, "mutagenesis": [ { "sequence_org": "G", "sequence_mut": "R", "comment": "Reduced infectivity.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "10482652", "url": "https://glygen.org/publication/PubMed/10482652" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "529", "end_pos": "529", "site_lbl": "Leu529", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Reduced infectivity.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "10482652", "url": "https://glygen.org/publication/PubMed/10482652" } ] }, { "sequence_org": "L", "sequence_mut": "R", "comment": "Reduced infectivity.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "10482652", "url": "https://glygen.org/publication/PubMed/10482652" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "532", "end_pos": "532", "site_lbl": "Ile532", "weight": 0.0, "mutagenesis": [ { "sequence_org": "I", "sequence_mut": "A", "comment": "Reduced infectivity.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "10482652", "url": "https://glygen.org/publication/PubMed/10482652" } ] }, { "sequence_org": "I", "sequence_mut": "R", "comment": "Almost complete loss of infectivity. 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No effect on transport of GP to the cell surface and incorporation onto virions.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "10482652", "url": "https://glygen.org/publication/PubMed/10482652" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "537", "end_pos": "537", "site_lbl": "Pro537", "weight": 0.0, "mutagenesis": [ { "sequence_org": "P", "sequence_mut": "R", "comment": "Almost complete loss of infectivity. 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Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "55", "end_pos": "55", "site_lbl": "Asp55", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "A", "comment": "80% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "D", "sequence_mut": "E", "comment": "No effect on viral entry.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "D", "sequence_mut": "K", "comment": "No effect on viral entry.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "57", "end_pos": "57", "site_lbl": "Leu57", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "L", "sequence_mut": "F", "comment": "90% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "L", "sequence_mut": "I", "comment": "90% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "L", "sequence_mut": "K", "comment": "90% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "601", "end_pos": "601", "site_lbl": "Cys601", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "S", "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "608", "end_pos": "608", "site_lbl": "Cys608", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "G", "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "609", "end_pos": "609", "site_lbl": "Cys609", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "G", "comment": "Induces GP1 secretion. Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "632", "end_pos": "632", "site_lbl": "Asp632", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "V", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "633", "end_pos": "633", "site_lbl": "Lys633", "weight": 0.0, "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] }, { "sequence_org": "K", "sequence_mut": "V", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "634", "end_pos": "634", "site_lbl": "Thr634", "weight": 0.0, "mutagenesis": [ { "sequence_org": "T", "sequence_mut": "I", "comment": "50% loss of release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "635", "end_pos": "635", "site_lbl": "Leu635", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "V", "comment": "60% loss of release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] }, { "sequence_org": "L", "sequence_mut": "V", "comment": "Increased GP shedding.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "26092855", "url": "https://glygen.org/publication/PubMed/26092855" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "636", "end_pos": "636", "site_lbl": "Pro636", "weight": 0.0, "mutagenesis": [ { "sequence_org": "P", "sequence_mut": "A", "comment": "60% loss of release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "637", "end_pos": "637", "site_lbl": "Asp637", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "E", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] }, { "sequence_org": "D", "sequence_mut": "L", "comment": "Increased release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] }, { "sequence_org": "D", "sequence_mut": "V", "comment": "Decreased GP shedding.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "26092855", "url": "https://glygen.org/publication/PubMed/26092855" } ] }, { "sequence_org": "D", "sequence_mut": "V", "comment": "Increased release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "638", "end_pos": "638", "site_lbl": "Gln638", "weight": 0.0, "mutagenesis": [ { "sequence_org": "Q", "sequence_mut": "V", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "639", "end_pos": "639", "site_lbl": "Gly639", "weight": 0.0, "mutagenesis": [ { "sequence_org": "G", "sequence_mut": "V", "comment": "40% loss of release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "63", "end_pos": "63", "site_lbl": "Leu63", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "90% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "L", "sequence_mut": "F", "comment": "Almost complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "L", "sequence_mut": "K", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "640", "end_pos": "640", "site_lbl": "Asp640", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "V", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "641", "end_pos": "641", "site_lbl": "Asn641", "weight": 0.0, "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "A", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "642", "end_pos": "642", "site_lbl": "Asp642", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "V", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "643", "end_pos": "643", "site_lbl": "Asn643", "weight": 0.0, "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "A", "comment": "No effect on release of soluble GP1,2delta.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "15103332", "url": "https://glygen.org/publication/PubMed/15103332" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "64", "end_pos": "64", "site_lbl": "Arg64", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "R", "sequence_mut": "E", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "R", "sequence_mut": "K", "comment": "No loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "660", "end_pos": "660", "site_lbl": "Gly660", "weight": 0.0, "mutagenesis": [ { "sequence_org": "G", "sequence_mut": "L", "comment": "About 60% loss of viral release; when associated with L-664.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "29669839", "url": "https://glygen.org/publication/PubMed/29669839" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "664", "end_pos": "664", "site_lbl": "Ala664", "weight": 0.0, "mutagenesis": [ { "sequence_org": "A", "sequence_mut": "L", "comment": "About 60% loss of viral release; when associated with L-660.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "29669839", "url": "https://glygen.org/publication/PubMed/29669839" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "670", "end_pos": "670", "site_lbl": "Cys670", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "A", "comment": "Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "11877482", "url": "https://glygen.org/publication/PubMed/11877482" }, { "database": "PubMed", "id": "11152533", "url": "https://glygen.org/publication/PubMed/11152533" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] }, { "sequence_org": "C", "sequence_mut": "F", "comment": "Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "11877482", "url": "https://glygen.org/publication/PubMed/11877482" }, { "database": "PubMed", "id": "11152533", "url": "https://glygen.org/publication/PubMed/11152533" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "672", "end_pos": "672", "site_lbl": "Cys672", "weight": 0.0, "mutagenesis": [ { "sequence_org": "C", "sequence_mut": "A", "comment": "Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "11152533", "url": "https://glygen.org/publication/PubMed/11152533" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] }, { "sequence_org": "C", "sequence_mut": "F", "comment": "Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "11152533", "url": "https://glygen.org/publication/PubMed/11152533" }, { "database": "PubMed", "id": "12438572", "url": "https://glygen.org/publication/PubMed/12438572" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "88", "end_pos": "88", "site_lbl": "Phe88", "weight": 0.0, "mutagenesis": [ { "sequence_org": "F", "sequence_mut": "A", "comment": "About 50% loss of ability to counteract host BST2.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" }, { "database": "PubMed", "id": "27707924", "url": "https://glygen.org/publication/PubMed/27707924" } ] }, { "sequence_org": "F", "sequence_mut": "A", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "F", "sequence_mut": "E", "comment": "Complete loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "F", "sequence_mut": "I", "comment": "No loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] }, { "uniprot_canonical_ac": "Q05320-1", "start_pos": "95", "end_pos": "95", "site_lbl": "Lys95", "weight": 0.0, "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "A", "comment": "80% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "K", "sequence_mut": "E", "comment": "80% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] }, { "sequence_org": "K", "sequence_mut": "R", "comment": "20% loss of virus capability to enter into host cell.", "evidence": [ { "database": "UniProtKB", "id": "Q05320", "url": "https://www.uniprot.org/uniprotkb/Q05320" } ] } ] } ], "record_id": "Q05320-1" }, { "uniprot_canonical_ac": "Q05322-1", "species": [ { "name": "Zaire ebolavirus (strain Mayinga-76)", "taxid": 128952, "evidence": [ { "database": "UniProtKB", "id": "Q05322", "url": "https://www.uniprot.org/uniprotkb/Q05322" } ], "common_name": "Zaire ebolavirus", "glygen_name": "Ebola (EBOV)", "reference_species": "Zaire ebolavirus (strain Mayinga-76) [128952]" } ], "length": 251, "chemical_mass": 28219.0, "gene_names": "VP24", "protein_name": "Membrane-associated protein VP24", "disease": [], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q05322", "url": "https://www.uniprot.org/uniprotkb/Q05322" } ], "pmid": "" }, { "name": "virion membrane", "id": "GO:0055036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055036", "evidence": [ { "database": "UniProtKB", "id": "Q05322", "url": "https://www.uniprot.org/uniprotkb/Q05322" } ], "pmid": "" }, { "name": "host cell plasma membrane", "id": "GO:0020002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020002", "evidence": [ { "database": "UniProtKB", "id": "Q05322", "url": "https://www.uniprot.org/uniprotkb/Q05322" } ], "pmid": "" }, { "name": "host cell endomembrane system", "id": "GO:0033645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033645", "evidence": [ { "database": "UniProtKB", "id": "Q05322", "url": "https://www.uniprot.org/uniprotkb/Q05322" } ], "pmid": "" } ], "molecular_function": [ { "name": "structural molecule activity", "id": "GO:0005198", 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"evidence": [ { "database": "UniProtKB", "id": "A1Z8X3", "url": "https://www.uniprot.org/uniprotkb/A1Z8X3" } ], "pmid": "" }, { "name": "centriole-centriole cohesion", "id": "GO:0010457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010457", "evidence": [ { "database": "UniProtKB", "id": "A1Z8X3", "url": "https://www.uniprot.org/uniprotkb/A1Z8X3" } ], "pmid": "" }, { "name": "centriole assembly", "id": "GO:0098534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098534", "evidence": [ { "database": "UniProtKB", "id": "A1Z8X3", "url": "https://www.uniprot.org/uniprotkb/A1Z8X3" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "A1Z8X3", "url": "https://www.uniprot.org/uniprotkb/A1Z8X3" } ], "pmid": "" }, { "name": "ciliary basal body organization", "id": "GO:0032053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032053", "evidence": [ { "database": 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fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 212, "chemical_mass": 24022.0, "gene_names": "GLaz;CG4604;DGLaz;Dmel\\CG4604;Dmel_CG4604;GLaz;Glaz;dGLaz;glaz", "protein_name": "", "disease": [], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" } ], "biological_process": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "response to reactive oxygen species", "id": "GO:0000302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000302", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" } ], "molecular_function": [ { "name": "lipoprotein particle receptor binding", "id": "GO:0070325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070325", "evidence": [ { "database": "UniProtKB", "id": "A1Z991", "url": "https://www.uniprot.org/uniprotkb/A1Z991" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z991-1" }, { "uniprot_canonical_ac": "A1Z9B5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9B5", "url": "https://www.uniprot.org/uniprotkb/A1Z9B5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 166, "chemical_mass": 18736.0, "gene_names": "Dmel\\CG10799;CG10799;CT30256;Dmel\\CG10799;Dmel_CG10799", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9B5-1" }, { "uniprot_canonical_ac": "A1Z9D5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9D5", "url": "https://www.uniprot.org/uniprotkb/A1Z9D5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 171, "chemical_mass": 19448.0, "gene_names": "Dmel\\CG30062;CG30062;Dmel\\CG30062;Dmel_CG30062", "protein_name": "lysozyme", "disease": [ { "disease_id": "DOID:2326", "name": "gastroenteritis", "description": "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. 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"UniProtKB", "id": "A1Z9D5", "url": "https://www.uniprot.org/uniprotkb/A1Z9D5" } ], "pmid": "" } ], "molecular_function": [ { "name": "lysozyme activity", "id": "GO:0003796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003796", "evidence": [ { "database": "UniProtKB", "id": "A1Z9D5", "url": "https://www.uniprot.org/uniprotkb/A1Z9D5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9D5-1" }, { "uniprot_canonical_ac": "A1Z9F8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 361, "chemical_mass": 38873.0, "gene_names": "NEST:bs27e02;CG13334;Dmel\\CG13334;Dmel_CG13334;NEST:bs27e02", "protein_name": "", "disease": [], "biological_process": [ { "name": "pyruvate biosynthetic process", "id": "GO:0042866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042866", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "lactate biosynthetic process from pyruvate", "id": "GO:0019244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019244", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "lactate metabolic process", "id": "GO:0006089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006089", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "lactate catabolic process", "id": "GO:1903457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903457", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "pyruvate catabolic process", "id": "GO:0042867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042867", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" } ], "molecular_function": [ { "name": "L-lactate dehydrogenase (NAD+) activity", "id": "GO:0004459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004459", "evidence": [ { "database": "UniProtKB", "id": "A1Z9F8", "url": "https://www.uniprot.org/uniprotkb/A1Z9F8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9F8-1" }, { "uniprot_canonical_ac": "A1Z9G3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 549, "chemical_mass": 59630.0, "gene_names": "S-Lap5;CG18369;Dmel\\CG18369;S-LAP 5;S-Lap5", "protein_name": "Crystallomitin S-Lap5", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" }, { "name": "major mitochondrial derivative", "id": "GO:0016008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016008", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" }, { "name": "mesoderm development", "id": "GO:0007498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007498", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" } ], "molecular_function": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A1Z9G3", "url": "https://www.uniprot.org/uniprotkb/A1Z9G3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9G3-1" }, { "uniprot_canonical_ac": "A1Z9J6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9J6", "url": "https://www.uniprot.org/uniprotkb/A1Z9J6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 155, "chemical_mass": 16861.0, "gene_names": "mRpL53;BcDNA:GM05817;CG30481;CG33184;Dmel\\CG30481;Dmel_CG30481;mRpL53", "protein_name": "Large ribosomal subunit protein mL53", "disease": [], "cellular_component": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "A1Z9J6", "url": "https://www.uniprot.org/uniprotkb/A1Z9J6" } ], "pmid": "" } ], "molecular_function": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A1Z9J6", "url": "https://www.uniprot.org/uniprotkb/A1Z9J6" } ], "pmid": "" } ], "biological_process": [ { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "A1Z9J6", "url": "https://www.uniprot.org/uniprotkb/A1Z9J6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9J6-1" }, { "uniprot_canonical_ac": "A1Z9N6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9N6", "url": "https://www.uniprot.org/uniprotkb/A1Z9N6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1092, "chemical_mass": 123827.0, "gene_names": "conv;ALS;Als;CG8561;CT24963;Dmel\\CG8561;Dmel_CG8561;capricious-like;conv;dALS;l(2)k06507b;tartan/capricious-like", "protein_name": "", "disease": [ { "disease_id": "DOID:0060870", "name": "isolated growth hormone deficiency", "description": "A hypopituitarism characterized by abnormally low levels, absence or impaired function of growth hormone in the absence of abnormalities in other pituitary hormones.", "url": "https://disease-ontology.org/term/DOID:0060870", "evidence": [ { "id": "0060870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060870" } ], "weight": 0.0 }, { "disease_id": "DOID:0061068", "name": "immunodeficiency 98", "description": "A combined T cell and B cell immunodeficiency that is characterized by recurrent infections associated with lymphoproliferation and autoinflammation in the first decade of life and that has_material_basis_in hemizygous mutation in the TLR8 gene on chromosome Xp22.", "url": "https://disease-ontology.org/term/DOID:0061068", "evidence": [ { "id": "0061068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061068" } ], "weight": 0.0 }, { "disease_id": "DOID:0080552", "name": "congenital disorder of glycosylation Ia", "description": "A congenital disorder of glycosylation I that is characterized by a severe encephalopathy with axial hypotonia, abnormal eye movement, pronounced psychomotor retardation, peripheral neuropathy, cerebellar hypoplasia, and retinitis pigmentosa and has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding phosphomannomutase-2 on chromosome 16p13.", "url": "https://disease-ontology.org/term/DOID:0080552", "evidence": [ { "id": "0080552", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080552" } ], "weight": 0.0 }, { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:0081013", "name": "severe COVID-19", "description": "A COVID-19 that is characterized by any of (1) Oxygen saturation < 90% on room air, (2) Respiratory rate > 30 breaths/min in adults and children > 5 years old, 60 breaths/min in children < 2 months old, 50 in children 211 months old, and 40 in children 15 years old, or (3) signs of severe respiratory distress (accessory muscle use, inability to complete full sentences, and, in children, very severe chest wall indrawing, grunting, central cyanosis, or presence of any other general danger signs.", "url": "https://disease-ontology.org/term/DOID:0081013", "evidence": [ { "id": "0081013", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081013" } ], "weight": 0.0 }, { "disease_id": "DOID:0112063", "name": "X-Linked immunodeficiency 74", "description": "A T cell deficiency characterized by severe respiratory insufficiency in response to infection with the COVID19 coronavirus and impaired signaling through the TLR7 pathway that has_material_basis_in hemizygous mutation in the TLR7 gene on chromosome Xp22.2.", "url": "https://disease-ontology.org/term/DOID:0112063", "evidence": [ { "id": "0112063", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112063" } ], "weight": 0.0 }, { "disease_id": "DOID:11168", "name": "anogenital venereal wart", "description": "A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, or throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.", "url": "https://disease-ontology.org/term/DOID:11168", "evidence": [ { "id": "11168", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11168" } ], "weight": 0.0 }, { "disease_id": "DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.", "url": "https://disease-ontology.org/term/DOID:1184", "evidence": [ { "id": "1184", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ], "weight": 0.0 }, { "disease_id": "DOID:1273", "name": "respiratory syncytial virus infectious disease", "description": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus (Orthopneumovirus hominis), which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.", "url": "https://disease-ontology.org/term/DOID:1273", "evidence": [ { "id": "1273", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1273" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.", "url": "https://disease-ontology.org/term/DOID:1574", "evidence": [ { "id": "1574", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:3310", "name": "atopic dermatitis", "description": "An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.", "url": "https://disease-ontology.org/term/DOID:3310", "evidence": [ { "id": "3310", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3310" } ], "weight": 0.0 }, { "disease_id": "DOID:3490", "name": "Noonan syndrome", "description": "A RASopathy that is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.", "url": "https://disease-ontology.org/term/DOID:3490", "evidence": [ { "id": "3490", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3490" } ], "weight": 0.0 }, { "disease_id": "DOID:4481", "name": "allergic rhinitis", "description": "A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.", "url": "https://disease-ontology.org/term/DOID:4481", "evidence": [ { "id": "4481", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4481" } ], "weight": 0.0 }, { "disease_id": "DOID:4483", "name": "rhinitis", "description": "A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. 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surrounding the heart.", "url": "https://disease-ontology.org/term/DOID:9074", "evidence": [ { "id": "9074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9074" } ], "weight": 0.0 } ], "biological_process": [ { "name": "motor neuron axon guidance", "id": "GO:0008045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008045", "evidence": [ { "database": "UniProtKB", "id": "A1Z9N6", "url": "https://www.uniprot.org/uniprotkb/A1Z9N6" } ], "pmid": "" }, { "name": "open tracheal system development", "id": "GO:0007424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007424", "evidence": [ { "database": "UniProtKB", "id": "A1Z9N6", "url": "https://www.uniprot.org/uniprotkb/A1Z9N6" } ], "pmid": "" }, { "name": "regulation of tube size, open tracheal system", "id": "GO:0035151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035151", "evidence": [ { "database": "UniProtKB", "id": "A1Z9N6", "url": "https://www.uniprot.org/uniprotkb/A1Z9N6" } ], "pmid": "" }, { "name": "regulation of tube length, open tracheal system", "id": "GO:0035159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035159", "evidence": [ { "database": "UniProtKB", "id": "A1Z9N6", "url": "https://www.uniprot.org/uniprotkb/A1Z9N6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9N6-1" }, { "uniprot_canonical_ac": "A1Z9P1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 559, "chemical_mass": 63851.0, "gene_names": "tej;CG8589;Dmel\\CG8589;Dmel_CG8589;TDRD5;Tejas;Tej;anon-EST:fe1D11;tej", "protein_name": "", "disease": [], "biological_process": [ { "name": "P granule organization", "id": "GO:0030719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030719", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" }, { "name": "secondary piRNA processing", "id": "GO:0140965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140965", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" }, { "name": "transposable element silencing by mRNA destabilization", "id": "GO:0141008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141008", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" } ], "cellular_component": [ { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "A1Z9P1", "url": "https://www.uniprot.org/uniprotkb/A1Z9P1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9P1-1" }, { "uniprot_canonical_ac": "A1Z9W2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1Z9W2", "url": "https://www.uniprot.org/uniprotkb/A1Z9W2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 320, "chemical_mass": 36401.0, "gene_names": "CG10220;CG10220;CG33506;Dmel\\CG33506;Dmel_CG33506", "protein_name": "Transmembrane protein 177", "disease": [], "cellular_component": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A1Z9W2", "url": "https://www.uniprot.org/uniprotkb/A1Z9W2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A1Z9W2", "url": "https://www.uniprot.org/uniprotkb/A1Z9W2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1Z9W2-1" }, { "uniprot_canonical_ac": "A1ZA03-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 899, "chemical_mass": 101283.0, "gene_names": "Pms2;CG8169;Dmel\\CG8169;Dmel_CG8169;Mlh2;PMS2;Pms2;dmlh-2;dmlh2;dpms2;pms2", "protein_name": "", "disease": [ { "disease_id": "DOID:0070275", "name": "hereditary nonpolyposis colorectal cancer type 4", "description": "A Lynch syndrome that has_material_basis_in heterozygous mutation in the PMS2 gene on chromosome 7p22.", "url": "https://disease-ontology.org/term/DOID:0070275", "evidence": [ { "id": "0070275", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070275" } ], "weight": 0.0 }, { "disease_id": "DOID:0112182", "name": "mismatch repair cancer syndrome", "description": "A syndrome characterized by predisposition for development of a broad spectrum of malignancies during childhood, including mainly brain, hematological and gastrointestinal cancers that has_material_basis_in homozygous or compound heterozygous mutation in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2 on chromosomes 3p22.2, 2p21-p16, 2p16.3, and 7p22.1, respectively.", "url": "https://disease-ontology.org/term/DOID:0112182", "evidence": [ { "id": "0112182", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112182" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:3883", "name": "Lynch syndrome", "description": "A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers.", "url": "https://disease-ontology.org/term/DOID:3883", "evidence": [ { "id": "3883", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3883" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" }, { "name": "mismatched DNA binding", "id": "GO:0030983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030983", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" }, { "name": "ATP-dependent DNA damage sensor activity", "id": "GO:0140664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140664", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" } ], "biological_process": [ { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" } ], "cellular_component": [ { "name": "MutLalpha complex", "id": "GO:0032389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032389", "evidence": [ { "database": "UniProtKB", "id": "A1ZA03", "url": "https://www.uniprot.org/uniprotkb/A1ZA03" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "A1ZA03-1", "start_pos": "20", "end_pos": "20", "site_lbl": "Thr20", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 20, "start_aa": "Thr", "end_pos": 20, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr20", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "A1ZA03-1" }, { "uniprot_canonical_ac": "A1ZA44-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZA44", "url": "https://www.uniprot.org/uniprotkb/A1ZA44" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 279, "chemical_mass": 31300.0, "gene_names": "Dmel\\CG30083;CG30083;Dmel\\CG30083;Dmel_CG30083;SP217", "protein_name": "Peptidase S1 domain-containing protein", "disease": [], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A1ZA44", "url": "https://www.uniprot.org/uniprotkb/A1ZA44" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A1ZA44", "url": "https://www.uniprot.org/uniprotkb/A1ZA44" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A1ZA44", "url": "https://www.uniprot.org/uniprotkb/A1ZA44" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1ZA44-1" }, { "uniprot_canonical_ac": "A1ZA77-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZA77", "url": "https://www.uniprot.org/uniprotkb/A1ZA77" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 174, "chemical_mass": 19564.0, "gene_names": 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], "molecular_function": [ { "name": "protein tyrosine kinase inhibitor activity", "id": "GO:0030292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030292", "evidence": [ { "database": "UniProtKB", "id": "A1ZAE2", "url": "https://www.uniprot.org/uniprotkb/A1ZAE2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A1ZAE2-1" }, { "uniprot_canonical_ac": "A1ZAF6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A1ZAF6", "url": "https://www.uniprot.org/uniprotkb/A1ZAF6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 600, "chemical_mass": 66849.0, "gene_names": "Menl-2;CG30097;CG7969;Dmel\\CG7969;Dmel_CG7969;Menl-2", "protein_name": "", "disease": [], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": 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"pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8DYI6-1" }, { "uniprot_canonical_ac": "A8DYL7-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DYL7", "url": "https://www.uniprot.org/uniprotkb/A8DYL7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 71, "chemical_mass": 8542.0, "gene_names": "pgc;CG11296;CG32885;CR32885;Dmel\\CG32885;Dmel_CG32885;PGC1;Pgc1;Pgc;pgc-1;pgc;pgr", "protein_name": "", "disease": [], "biological_process": [ { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A8DYL7", "url": "https://www.uniprot.org/uniprotkb/A8DYL7" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": 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"A8DYL9-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DYL9", "url": "https://www.uniprot.org/uniprotkb/A8DYL9" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 50, "chemical_mass": 5641.0, "gene_names": "Dmel\\CG34208;CG34208;Dmel\\CG34208;Dmel_CG34208", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8DYL9-1" }, { "uniprot_canonical_ac": "A8DYM6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DYM6", "url": "https://www.uniprot.org/uniprotkb/A8DYM6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 77, "chemical_mass": 8557.0, "gene_names": "CG13512;CG13512;CG42566;Dmel\\CG42566;Dmel_CG42566", "protein_name": "LITAF 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"database": "UniProtKB", "id": "A8DYM8", "url": "https://www.uniprot.org/uniprotkb/A8DYM8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 501, "chemical_mass": 54840.0, "gene_names": "BcDNA:AT17081;BcDNA:AT17081;CG13528;CG30271;Dmel\\CG30271;Dmel_CG30271", "protein_name": "Protein bfr2", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8DYM8-1" }, { "uniprot_canonical_ac": "A8DZ13-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DZ13", "url": "https://www.uniprot.org/uniprotkb/A8DZ13" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 62, "chemical_mass": 6801.0, "gene_names": "Dmel\\CG34170;CG34170;Dmel\\CG34170;Dmel_CG34170", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8DZ13-1" }, { "uniprot_canonical_ac": "A8DZ19-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1310, "chemical_mass": 144424.0, "gene_names": "RtGEF;38C.40;ARHGEF7;CG10043;Dmel\\CG10043;Dmel_CG10043;DrhoGEF;DrtGEF;Pix;RacGEF;Rho/RacGEF;RhoGEF;RtGEF;beta-PIX;betaPIX;dPIX;dPix;dpix;pix;rhoGEF;rtGEF", "protein_name": "", "disease": [ { "disease_id": "DOID:1059", "name": "intellectual disability", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.", "url": "https://disease-ontology.org/term/DOID:1059", "evidence": [ { "id": "1059", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1059" } ], "weight": 0.0 }, { "disease_id": "DOID:6713", "name": "cerebrovascular disease", "description": "An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.", "url": "https://disease-ontology.org/term/DOID:6713", "evidence": [ { "id": "6713", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6713" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of organ growth", "id": "GO:0046621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046621", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "positive regulation of hippo signaling", "id": "GO:0035332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "regulation of synapse organization", "id": "GO:0050807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050807", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" } ], "molecular_function": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" }, { "name": "muscle cell postsynaptic specialization", "id": "GO:0097482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097482", "evidence": [ { "database": "UniProtKB", "id": "A8DZ19", "url": "https://www.uniprot.org/uniprotkb/A8DZ19" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "A8DZ19-1", "start_pos": "194", "end_pos": "194", "site_lbl": "Thr194", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": 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"phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A8JNI3", "url": "https://www.uniprot.org/uniprotkb/A8JNI3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8JNI3-1" }, { "uniprot_canonical_ac": "A8JNU6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8JNU6", "url": "https://www.uniprot.org/uniprotkb/A8JNU6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1105, "chemical_mass": 122896.0, "gene_names": "Ogdh1;141810_at;CG11661;DOGDH;Dmel\\CG11661;Dmel_CG11661;E1;Nc73EF;Nc73eF;OGDH;Ogdh;alpha-KGDH-E1;anon-WO0118547.329;dOgdh", "protein_name": "2-oxoglutarate dehydrogenase, mitochondrial", "disease": [ { "disease_id": "DOID:0070468", "name": "Yoon-Bellen neurodevelopmental syndrome", "description": "A syndrome characterized by onset in the first decade of highly variable neurodevelopmental phenotypes including global developmental delay, intellectual disability, seizures, hearing and visual problems, and ataxia that has_material_basis_in homozygous or compound heterozygous mutation in the OGDHL gene on chromosome 10q11.23.", "url": "https://disease-ontology.org/term/DOID:0070468", "evidence": [ { "id": "0070468", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070468" } ], "weight": 0.0 }, { "disease_id": "DOID:0081326", "name": "oxoglutarate dehydrogenase deficiency", "description": "An amino acid metabolic disorder that is characterized by infantile and pediatric onset basal ganglia-associated movement disorders, hypotonia, developmental delays, ataxia, and seizures and that has_material_basis_in homozygous mutation in the oxoglutarate dehydrogenase gene (OGDH) on chromosome 7p13.", "url": "https://disease-ontology.org/term/DOID:0081326", "evidence": [ { 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"Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 311, "chemical_mass": 34627.0, "gene_names": "Dmel\\CG34277;CG34277;Dmel\\CG34277;Dmel_CG34277", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8JQT7-1" }, { "uniprot_canonical_ac": "A8JQX6-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 362, "chemical_mass": 41611.0, "gene_names": "Dmel\\CG4820;CG4820;Dmel\\CG4820;Dmel_CG4820", "protein_name": "Transcription factor Ouib", "disease": [ { "disease_id": "DOID:0060318", "name": "acute promyelocytic leukemia", "description": "An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by 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"molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A8JQX6", "url": "https://www.uniprot.org/uniprotkb/A8JQX6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8JQX6-1" }, { "uniprot_canonical_ac": "A8JQZ1-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A8JQZ1", "url": "https://www.uniprot.org/uniprotkb/A8JQZ1" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 234, "chemical_mass": 27738.0, "gene_names": "Dmel\\CG46281;CG12360;CG46281;Dmel\\CG46281;Dmel_CG46281", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "A8JQZ1-1" }, { "uniprot_canonical_ac": "Q9VD71-1", "species": [ { "name": "Drosophila 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"chemical_mass": 29471.0, "gene_names": "lectin-22C;AC 004716A;AC004716a;CG15378;CG42295;Dmel\\CG42295;Dmel_CG42295;lectin-22C", "protein_name": "", "disease": [ { "disease_id": "DOID:0060576", "name": "3MC syndrome 2", "description": "A 3MC syndrome that has_material_basis_in autosomal recessive inheritance of homozygous mutation in the collectin subfamily member 11 gene (COLEC11) on chromosome 2p25.", "url": "https://disease-ontology.org/term/DOID:0060576", "evidence": [ { "id": "0060576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060576" } ], "weight": 0.0 }, { "disease_id": "DOID:0060577", "name": "3MC syndrome 3", "description": "A 3MC syndrome that has_material_basis_in a compound heterozygous mutation in the COLEC10 gene on chromosome 8q24.", "url": "https://disease-ontology.org/term/DOID:0060577", "evidence": [ { "id": "0060577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060577" } ], "weight": 0.0 }, { "disease_id": "DOID:674", "name": "cleft palate", "description": "An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.", "url": "https://disease-ontology.org/term/DOID:674", "evidence": [ { "id": "674", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:674" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" } ], "biological_process": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" }, { "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" } ], "molecular_function": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" }, { "name": "galactose binding", "id": "GO:0005534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005534", "evidence": [ { "database": "UniProtKB", "id": "B7YZU7", "url": "https://www.uniprot.org/uniprotkb/B7YZU7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B7YZU7-1" }, { "uniprot_canonical_ac": "B7YZX0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "B7YZX0", "url": "https://www.uniprot.org/uniprotkb/B7YZX0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1677, "chemical_mass": 183512.0, "gene_names": "Hasp;CG10186;CT28647;Dmel\\CG10186;Dmel_CG10186;Hasp;anon-EST:Posey189;hasp", "protein_name": "", "disease": [ { "disease_id": "DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen.", "url": "https://disease-ontology.org/term/DOID:0051061", "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ], "weight": 0.0 }, { "disease_id": "DOID:0060903", "name": "thrombosis", "description": "A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.", "url": "https://disease-ontology.org/term/DOID:0060903", "evidence": [ { "id": "0060903", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060903" } ], "weight": 0.0 }, { "disease_id": "DOID:0080301", "name": "atypical hemolytic-uremic syndrome", "description": "A complement deficiency that is characterized by mechanical hemolytic anemia, thrombocytopenia, and renal dysfunction.", "url": "https://disease-ontology.org/term/DOID:0080301", "evidence": [ { "id": "0080301", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080301" } ], "weight": 0.0 }, { "disease_id": "DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum.", "url": "https://disease-ontology.org/term/DOID:0080600", "evidence": [ { "id": "0080600", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ], "weight": 0.0 }, { "disease_id": "DOID:0081150", "name": "common variable immunodeficiency 7", "description": "A common variable immunodeficiency that has_material_basis_in compound heterozygous mutation in the CD21 gene (CR2) on chromosome 1q32.", "url": "https://disease-ontology.org/term/DOID:0081150", "evidence": [ { "id": "0081150", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081150" } ], "weight": 0.0 }, { "disease_id": "DOID:0110017", "name": "age related macular degeneration 4", "description": "An age related macular degeneration conferred by variation in the CFH gene on chromosome 1q31.", "url": "https://disease-ontology.org/term/DOID:0110017", "evidence": [ { "id": "0110017", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110017" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10611", "name": "protein-losing enteropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:10611", "evidence": [ { "id": "10611", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10611" } ], "weight": 0.0 }, { "disease_id": "DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.", "url": "https://disease-ontology.org/term/DOID:12365", "evidence": [ { "id": "12365", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ], "weight": 0.0 }, { "disease_id": "DOID:12554", "name": "hemolytic-uremic syndrome", "description": "A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs.", "url": "https://disease-ontology.org/term/DOID:12554", "evidence": [ { "id": "12554", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12554" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.", "url": "https://disease-ontology.org/term/DOID:2349", "evidence": [ { "id": "2349", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ], "weight": 0.0 }, { "disease_id": "DOID:2870", "name": "endometrial adenocarcinoma", "description": "An endometrial carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:2870", "evidence": [ { "id": "2870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2870" } ], "weight": 0.0 }, { "disease_id": "DOID:2920", "name": "membranoproliferative glomerulonephritis", "description": "", "url": "https://disease-ontology.org/term/DOID:2920", "evidence": [ { "id": "2920", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2920" } ], "weight": 0.0 }, { "disease_id": "DOID:2988", "name": "antiphospholipid syndrome", "description": "An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).", "url": "https://disease-ontology.org/term/DOID:2988", "evidence": [ { "id": "2988", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2988" } ], "weight": 0.0 }, { "disease_id": "DOID:341", "name": "peripheral vascular disease", "description": "A vascular disease that is characterized by obstruction of vessels not within the coronary, aortic arch vasculature, or brain.", "url": "https://disease-ontology.org/term/DOID:341", "evidence": [ { "id": "341", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:341" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4449", "name": "macular retinal edema", "description": "", "url": "https://disease-ontology.org/term/DOID:4449", "evidence": [ { "id": "4449", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4449" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:576", "name": "proteinuria", "description": "A kidney disease that is characterized by the presence of excess proteins in the urine.", "url": "https://disease-ontology.org/term/DOID:576", "evidence": [ { "id": "576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:576" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:769", "name": "neuroblastoma", "description": "An autonomic nervous system neoplasm that derives_from immature nerve cells.", "url": "https://disease-ontology.org/term/DOID:769", "evidence": [ { "id": "769", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:769" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 }, { "disease_id": "DOID:9074", "name": "systemic lupus erythematosus", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.", "url": "https://disease-ontology.org/term/DOID:9074", "evidence": [ { "id": "9074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9074" } ], "weight": 0.0 }, { "disease_id": "DOID:9261", "name": "nasopharynx carcinoma", "description": "A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.", "url": "https://disease-ontology.org/term/DOID:9261", "evidence": [ { "id": "9261", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9261" } ], "weight": 0.0 }, { "disease_id": "DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.", "url": "https://disease-ontology.org/term/DOID:9351", "evidence": [ { "id": "9351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9351" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "B7YZX0", "url": "https://www.uniprot.org/uniprotkb/B7YZX0" } ], "pmid": "" } ], "cellular_component": [ { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "B7YZX0", "url": "https://www.uniprot.org/uniprotkb/B7YZX0" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of dendrite development", "id": "GO:0050773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050773", "evidence": [ { "database": "UniProtKB", "id": "B7YZX0", "url": "https://www.uniprot.org/uniprotkb/B7YZX0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "B7YZX0-1", "start_pos": "309", "end_pos": "309", "site_lbl": "Thr309", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 309, "start_aa": "Thr", "end_pos": 309, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr309", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "B7YZX0-1" }, { "uniprot_canonical_ac": "B7Z078-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 448, "chemical_mass": 47763.0, "gene_names": "Rnf146;BcDNA:GM01527;CG8786;DRNF146;Dmel\\CG8786;Dmel_CG8786;Iduna;RNF146;Rnf146", "protein_name": "E3 ubiquitin-protein ligase", "disease": [ { "disease_id": "DOID:2256", "name": "osteochondrodysplasia", "description": "A bone development disease that results_in defective development of cartilage or bone.", "url": "https://disease-ontology.org/term/DOID:2256", "evidence": [ { "id": "2256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2256" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "poly-ADP-D-ribose binding", "id": "GO:0072572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072572", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" } ], "biological_process": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "negative regulation of JNK cascade", "id": "GO:0046329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046329", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "B7Z078", "url": "https://www.uniprot.org/uniprotkb/B7Z078" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "B7Z078-1" }, { "uniprot_canonical_ac": "B7Z0E2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ 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cells due to a lack of oxygen.", "url": "https://disease-ontology.org/term/DOID:0051061", "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ], "weight": 0.0 }, { "disease_id": "DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:0060074", "evidence": [ { "id": "0060074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ], "weight": 0.0 }, { "disease_id": "DOID:0060108", "name": "brain glioma", "description": "A brain cancer that has_material_basis_in glial cells.", "url": "https://disease-ontology.org/term/DOID:0060108", "evidence": [ { "id": "0060108", "database": "AGR", "url": 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"disease_id": "DOID:0060230", "name": "basal ganglia calcification", "description": "A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills.", "url": "https://disease-ontology.org/term/DOID:0060230", "evidence": [ { "id": "0060230", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060230" } ], "weight": 0.0 }, { "disease_id": "DOID:0060669", "name": "cerebral cavernous malformation", "description": "A cerebrovascular disease that is characterized by dilated blood-filled capillaries lacking structural support.", "url": "https://disease-ontology.org/term/DOID:0060669", "evidence": [ { "id": "0060669", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060669" } ], "weight": 0.0 }, { "disease_id": "DOID:0060688", "name": "arteriovenous malformations of the brain", "description": "A central nervous system benign neoplasm that derives_from endothelial cells and that is located_in the brain.", "url": "https://disease-ontology.org/term/DOID:0060688", "evidence": [ { "id": "0060688", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060688" } ], "weight": 0.0 }, { "disease_id": "DOID:0070210", "name": "hereditary lymphedema IA", "description": "A hereditary lymphedema characterized by autosomal dominant inheritance that has_material_basis_in mutation in the FLT4 gene on chromosome 5q35.", "url": "https://disease-ontology.org/term/DOID:0070210", "evidence": [ { "id": "0070210", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070210" } ], "weight": 0.0 }, { "disease_id": "DOID:0070666", "name": "infantile myofibromatosis 1", "description": "An infantile myofibromatosis that has_material_basis_in heterozygous mutation in the PDGFRB gene on chromosome 5q32.", "url": "https://disease-ontology.org/term/DOID:0070666", "evidence": [ { "id": "0070666", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070666" } ], "weight": 0.0 }, { "disease_id": "DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa.", "url": "https://disease-ontology.org/term/DOID:0080199", "evidence": [ { "id": "0080199", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ], "weight": 0.0 }, { "disease_id": "DOID:0080523", "name": "adult-onset leukoencephalopathy with axonal spheroids and pigmented glia", "description": "A leukodystrophy that is characterized by progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy and has_material_basis_in heterozygous mutation in the CSF1R gene on chromosome 5q32.", "url": "https://disease-ontology.org/term/DOID:0080523", "evidence": [ { "id": "0080523", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080523" } ], "weight": 0.0 }, { "disease_id": "DOID:0080547", "name": "metabolic dysfunction-associated steatohepatitis", "description": "A metabolic dysfunction-associated steatotic liver disease characterized by the presence of inflammation with hepatocyte injury such as ballooning, with or without fibrosis.", "url": "https://disease-ontology.org/term/DOID:0080547", "evidence": [ { "id": "0080547", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080547" } ], "weight": 0.0 }, { "disease_id": "DOID:0080630", "name": "B-lymphoblastic leukemia/lymphoma", "description": "A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow.", "url": "https://disease-ontology.org/term/DOID:0080630", "evidence": [ { "id": "0080630", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080630" } ], "weight": 0.0 }, { "disease_id": "DOID:0081082", "name": "acute myelomonocytic leukemia", "description": "An acute myeloid leukemia that is characterized by the proliferation of both neutrophil and monocyte precursors.", "url": "https://disease-ontology.org/term/DOID:0081082", "evidence": [ { "id": "0081082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081082" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10487", "name": "Hirschsprung's disease", "description": "A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.", "url": "https://disease-ontology.org/term/DOID:10487", "evidence": [ { "id": "10487", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10487" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:10591", "name": "pre-eclampsia", "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.", "url": "https://disease-ontology.org/term/DOID:10591", "evidence": [ { "id": "10591", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10591" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:10873", "name": "Kuhnt-Junius degeneration", "description": "", "url": "https://disease-ontology.org/term/DOID:10873", "evidence": [ { "id": "10873", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10873" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:11132", "name": "prostatic hypertrophy", "description": "", "url": "https://disease-ontology.org/term/DOID:11132", "evidence": [ { "id": "11132", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11132" } ], "weight": 0.0 }, { "disease_id": "DOID:1115", "name": "sarcoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.", "url": "https://disease-ontology.org/term/DOID:1115", "evidence": [ { "id": "1115", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1115" } ], "weight": 0.0 }, { "disease_id": "DOID:11382", "name": "corneal neovascularization", "description": "", "url": "https://disease-ontology.org/term/DOID:11382", "evidence": [ { "id": "11382", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11382" } ], "weight": 0.0 }, { "disease_id": "DOID:11446", "name": "sciatic neuropathy", "description": "", "url": "https://disease-ontology.org/term/DOID:11446", "evidence": [ { "id": "11446", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ], "weight": 0.0 }, { "disease_id": "DOID:11650", "name": "bronchopulmonary dysplasia", "description": "A lung disease that is characterized by underdeveloped lungs in newborns that can be easily irritated or inflamed after birth resulting in damage to the alveoli of the lungs and bronchi. Most newborns who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds at birth, and have breathing problems.", "url": "https://disease-ontology.org/term/DOID:11650", "evidence": [ { "id": "11650", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11650" } ], "weight": 0.0 }, { "disease_id": "DOID:12215", "name": "oligohydramnios", "description": "A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.", "url": "https://disease-ontology.org/term/DOID:12215", "evidence": [ { "id": "12215", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12215" } ], "weight": 0.0 }, { "disease_id": "DOID:1240", "name": "leukemia", "description": "A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.", "url": "https://disease-ontology.org/term/DOID:1240", "evidence": [ { "id": "1240", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1240" } ], "weight": 0.0 }, { "disease_id": "DOID:13025", "name": "retinopathy of prematurity", "description": "", "url": "https://disease-ontology.org/term/DOID:13025", "evidence": [ { "id": "13025", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13025" } ], "weight": 0.0 }, { "disease_id": "DOID:13207", "name": "proliferative diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:13207", "evidence": [ { "id": "13207", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13207" } ], "weight": 0.0 }, { "disease_id": "DOID:13208", "name": "background diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:13208", "evidence": [ { "id": "13208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13208" } ], "weight": 0.0 }, { "disease_id": "DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ], "weight": 0.0 }, { "disease_id": "DOID:13378", "name": "Kawasaki disease", "description": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels and that symptoms of fever, congestion of ocular conjunctivae, reddening of lips, reddening of oral cavity, protuberance of tongue papillae and edema of extremities.", "url": "https://disease-ontology.org/term/DOID:13378", "evidence": [ { "id": "13378", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13378" } ], "weight": 0.0 }, { "disease_id": "DOID:13619", "name": "extrahepatic cholestasis", "description": "A cholestasis resulting from causes located_in bile ducts outside the liver.", "url": "https://disease-ontology.org/term/DOID:13619", "evidence": [ { "id": "13619", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13619" } ], "weight": 0.0 }, { "disease_id": "DOID:13812", "name": "adhesions of uterus", "description": "A uterine disease that is characterized by the presence of scar tissue which attaches the uterus to another structure.", "url": "https://disease-ontology.org/term/DOID:13812", "evidence": [ { "id": "13812", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13812" } ], "weight": 0.0 }, { "disease_id": "DOID:1475", "name": "lymphangioma", "description": "A benign vascular tumor that is composed of dilated lymphatic channels.", "url": "https://disease-ontology.org/term/DOID:1475", "evidence": [ { "id": "1475", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1475" } ], "weight": 0.0 }, { "disease_id": "DOID:1577", "name": "limited scleroderma", "description": "", "url": "https://disease-ontology.org/term/DOID:1577", "evidence": [ { "id": "1577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1577" } ], "weight": 0.0 }, { "disease_id": "DOID:1580", "name": "diffuse scleroderma", "description": "", "url": "https://disease-ontology.org/term/DOID:1580", "evidence": [ { "id": "1580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1580" } ], "weight": 0.0 }, { "disease_id": "DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland.", "url": "https://disease-ontology.org/term/DOID:1612", "evidence": [ { "id": "1612", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ], "weight": 0.0 }, { "disease_id": "DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.", "url": "https://disease-ontology.org/term/DOID:162", "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ], "weight": 0.0 }, { "disease_id": "DOID:1679", "name": "cystitis", "description": "A bladder disease that is characterized by inflammation of the bladder.", "url": "https://disease-ontology.org/term/DOID:1679", "evidence": [ { "id": "1679", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1679" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:1875", "name": "impotence", "description": "A sexual dysfunction that is characterized by persistent or recurrent inability to achieve or to maintain an erection during sexual activity.", "url": "https://disease-ontology.org/term/DOID:1875", "evidence": [ { "id": "1875", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1875" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:1967", "name": "leiomyosarcoma", "description": "A smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.", "url": "https://disease-ontology.org/term/DOID:1967", "evidence": [ { "id": "1967", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1967" } ], "weight": 0.0 }, { "disease_id": "DOID:2154", "name": "nephroblastoma", "description": "A kidney cancer that affects the kidneys and typically occuring in children.", "url": "https://disease-ontology.org/term/DOID:2154", "evidence": [ { "id": "2154", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2154" } ], "weight": 0.0 }, { "disease_id": "DOID:2226", "name": "myeloproliferative neoplasm", "description": "A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.", "url": "https://disease-ontology.org/term/DOID:2226", "evidence": [ { "id": "2226", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2226" } ], "weight": 0.0 }, { "disease_id": "DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand.", "url": "https://disease-ontology.org/term/DOID:2316", "evidence": [ { "id": "2316", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ], "weight": 0.0 }, { "disease_id": "DOID:234", "name": "colon adenocarcinoma", "description": "A colon carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:234", "evidence": [ { "id": "234", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:234" } ], "weight": 0.0 }, { "disease_id": "DOID:2349", "name": "arteriosclerosis", "description": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.", "url": "https://disease-ontology.org/term/DOID:2349", "evidence": [ { "id": "2349", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2349" } ], "weight": 0.0 }, { "disease_id": "DOID:2526", "name": "prostate adenocarcinoma", "description": "A prostate carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:2526", "evidence": [ { "id": "2526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2526" } ], "weight": 0.0 }, { "disease_id": "DOID:264", "name": "hemangiopericytoma", "description": "A hemangiopericytic tumor that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries.", "url": "https://disease-ontology.org/term/DOID:264", "evidence": [ { "id": "264", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:264" } ], "weight": 0.0 }, { "disease_id": "DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells.", "url": "https://disease-ontology.org/term/DOID:2671", "evidence": [ { "id": "2671", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ], "weight": 0.0 }, { "disease_id": "DOID:2696", "name": "Leydig cell tumor", "description": "A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located_in ovary or testicle.", "url": "https://disease-ontology.org/term/DOID:2696", "evidence": [ { "id": "2696", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2696" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:289", "name": "endometriosis", "description": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.", "url": "https://disease-ontology.org/term/DOID:289", "evidence": [ { "id": "289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:289" } ], "weight": 0.0 }, { "disease_id": "DOID:2999", "name": "granulosa cell tumor", "description": "A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma.", "url": "https://disease-ontology.org/term/DOID:2999", "evidence": [ { "id": "2999", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2999" } ], "weight": 0.0 }, { "disease_id": "DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.", "url": "https://disease-ontology.org/term/DOID:3008", "evidence": [ { "id": "3008", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ], "weight": 0.0 }, { "disease_id": "DOID:3042", "name": "allergic contact dermatitis", "description": "A contact dermatitis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.", "url": "https://disease-ontology.org/term/DOID:3042", "evidence": [ { "id": "3042", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3042" } ], "weight": 0.0 }, { "disease_id": "DOID:305", "name": "carcinoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:305", "evidence": [ { "id": "305", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:305" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine.", "url": "https://disease-ontology.org/term/DOID:3070", "evidence": [ { "id": "3070", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ], "weight": 0.0 }, { "disease_id": "DOID:3082", "name": "interstitial lung disease", "description": "A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough.", "url": "https://disease-ontology.org/term/DOID:3082", "evidence": [ { "id": "3082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3082" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3179", "name": "inverted papilloma", "description": "", "url": "https://disease-ontology.org/term/DOID:3179", "evidence": [ { "id": "3179", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3179" } ], "weight": 0.0 }, { "disease_id": "DOID:3192", "name": "neurilemmoma", "description": "A neuroma that is characterized as a benign nerve sheath tumor that is composed of Schwann cells.", "url": "https://disease-ontology.org/term/DOID:3192", "evidence": [ { "id": "3192", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3192" } ], "weight": 0.0 }, { "disease_id": "DOID:3263", "name": "piebaldism", "description": "An integumentary system disease characterized by congenital absence of melanocytes in areas of the skin and hair that has_material_basis_in heterozygous mutation in the KIT gene on chromosome 4q12.", "url": "https://disease-ontology.org/term/DOID:3263", "evidence": [ { "id": "3263", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3263" } ], "weight": 0.0 }, { "disease_id": "DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.", "url": "https://disease-ontology.org/term/DOID:332", "evidence": [ { "id": "332", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:332" } ], "weight": 0.0 }, { "disease_id": "DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:3459", "evidence": [ { "id": "3459", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ], "weight": 0.0 }, { "disease_id": "DOID:350", "name": "mastocytosis", "description": "", "url": "https://disease-ontology.org/term/DOID:350", "evidence": [ { "id": "350", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:350" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:3594", "name": "choriocarcinoma", "description": "A placenta cancer that has_material_basis_in trophoblastic cells.", "url": "https://disease-ontology.org/term/DOID:3594", "evidence": [ { "id": "3594", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3594" } ], "weight": 0.0 }, { "disease_id": "DOID:3744", "name": "cervical squamous cell carcinoma", "description": "A cervix carcinoma that has_material_basis_in squamous cells of the cervix.", "url": "https://disease-ontology.org/term/DOID:3744", "evidence": [ { "id": "3744", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3744" } ], "weight": 0.0 }, { "disease_id": "DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. It can be caused by inhaling hazardous chemicals, certain diseases, medication and genetics or unknown causes.", "url": "https://disease-ontology.org/term/DOID:3770", "evidence": [ { "id": "3770", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ], "weight": 0.0 }, { "disease_id": "DOID:3827", "name": "congenital diaphragmatic hernia", "description": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs.", "url": "https://disease-ontology.org/term/DOID:3827", "evidence": [ { "id": "3827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3827" } ], "weight": 0.0 }, { "disease_id": "DOID:3840", "name": "craniopharyngioma", "description": "", "url": "https://disease-ontology.org/term/DOID:3840", "evidence": [ { "id": "3840", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3840" } ], "weight": 0.0 }, { "disease_id": "DOID:3907", "name": "lung squamous cell carcinoma", "description": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell.", "url": "https://disease-ontology.org/term/DOID:3907", "evidence": [ { "id": "3907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3907" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:3963", "name": "thyroid gland carcinoma", "description": "A thyroid gland cancer that has_material_basis_in epithelial cells.", "url": "https://disease-ontology.org/term/DOID:3963", "evidence": [ { "id": "3963", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3963" } ], "weight": 0.0 }, { "disease_id": "DOID:418", "name": "systemic scleroderma", "description": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.", "url": "https://disease-ontology.org/term/DOID:418", "evidence": [ { "id": "418", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:418" } ], "weight": 0.0 }, { "disease_id": "DOID:4202", "name": "brain stem glioma", "description": "A brain stem cancer that is characterized by mass lesion of the brainstem, associated cranial nerve nuclei and long tracts, has_material_basis_in abnormally proliferating cells, derives_from glial cells.", "url": "https://disease-ontology.org/term/DOID:4202", "evidence": [ { "id": "4202", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4202" } ], "weight": 0.0 }, { "disease_id": "DOID:4226", "name": "endometrial stromal sarcoma", "description": "An endometrial stromal tumor that has_material_basis_in connective tissue.", "url": "https://disease-ontology.org/term/DOID:4226", "evidence": [ { "id": "4226", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4226" } ], "weight": 0.0 }, { "disease_id": "DOID:4297", "name": "scimitar syndrome", "description": "A congenital heart disease that is characterized by partial or entire anomalous curved venous drainage of the right lung to the inferior vena cava, association with variable right lung and pulmonary artery hypoplasia, dextraposition of the heart and an anomalous systemic blood supply to the ipsilateral lung.", "url": "https://disease-ontology.org/term/DOID:4297", "evidence": [ { "id": "4297", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4297" } ], "weight": 0.0 }, { "disease_id": "DOID:4440", "name": "seminoma", "description": "A germinoma that has_material_basis_in cells that make sperm and eggs.", "url": "https://disease-ontology.org/term/DOID:4440", "evidence": [ { "id": "4440", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4440" } ], "weight": 0.0 }, { "disease_id": "DOID:4441", "name": "dysgerminoma", "description": "A germ cell cancer that derives_from cells that give rise to egg cells.", "url": "https://disease-ontology.org/term/DOID:4441", "evidence": [ { "id": "4441", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4441" } ], "weight": 0.0 }, { "disease_id": "DOID:4448", "name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 }, { "disease_id": "DOID:4449", "name": "macular retinal edema", "description": "", "url": "https://disease-ontology.org/term/DOID:4449", "evidence": [ { "id": "4449", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4449" } ], "weight": 0.0 }, { "disease_id": "DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.", "url": "https://disease-ontology.org/term/DOID:4450", "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ], "weight": 0.0 }, { "disease_id": "DOID:4511", "name": "breast angiosarcoma", "description": "An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.", "url": "https://disease-ontology.org/term/DOID:4511", "evidence": [ { "id": "4511", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4511" } ], "weight": 0.0 }, { "disease_id": "DOID:4905", "name": "pancreatic carcinoma", "description": "A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas.", "url": "https://disease-ontology.org/term/DOID:4905", "evidence": [ { "id": "4905", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4905" } ], "weight": 0.0 }, { "disease_id": "DOID:4914", "name": "esophagus adenocarcinoma", "description": "An esophageal carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:4914", "evidence": [ { "id": "4914", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4914" } ], "weight": 0.0 }, { "disease_id": "DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.", "url": "https://disease-ontology.org/term/DOID:4947", "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ], "weight": 0.0 }, { "disease_id": "DOID:4971", "name": "myelofibrosis", "description": "A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.", "url": "https://disease-ontology.org/term/DOID:4971", "evidence": [ { "id": "4971", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4971" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:5389", "name": "oxyphilic adenoma", "description": "", "url": "https://disease-ontology.org/term/DOID:5389", "evidence": [ { "id": "5389", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5389" } ], "weight": 0.0 }, { "disease_id": "DOID:5409", "name": "lung small cell carcinoma", "description": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:5409", "evidence": [ { "id": "5409", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5409" } ], "weight": 0.0 }, { "disease_id": "DOID:5425", "name": "ovarian hyperstimulation syndrome", "description": "An ovarian disease that is characterized by cystic enlargement of the ovaries and a fluid shift from the intravascular to the third space and has_symptom abdominal pain, has_symptom nausea and has_symptom vomiting. This disease is an iatrogenic complication of assisted reproduction technology.", "url": "https://disease-ontology.org/term/DOID:5425", "evidence": [ { "id": "5425", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5425" } ], "weight": 0.0 }, { "disease_id": "DOID:5603", "name": "T-cell acute lymphoblastic leukemia", "description": "An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood.", "url": "https://disease-ontology.org/term/DOID:5603", "evidence": [ { "id": "5603", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5603" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:585", "name": "nephrolithiasis", "description": "A kidney disease characterized by the formation of stoney concentrations in the kidneys.", "url": "https://disease-ontology.org/term/DOID:585", "evidence": [ { "id": "585", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:585" } ], "weight": 0.0 }, { "disease_id": "DOID:6039", "name": "uveal melanoma", "description": "A uveal cancer that has_material_basis_in uvea pigment cells.", "url": "https://disease-ontology.org/term/DOID:6039", "evidence": [ { "id": "6039", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6039" } ], "weight": 0.0 }, { "disease_id": "DOID:6171", "name": "uterine carcinosarcoma", "description": "A uterine body mixed cancer that has_material_basis_in both endometrial carcinoma and sarcoma.", "url": "https://disease-ontology.org/term/DOID:6171", "evidence": [ { "id": "6171", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6171" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:7736", "name": "retinal telangiectasia", "description": "", "url": "https://disease-ontology.org/term/DOID:7736", "evidence": [ { "id": "7736", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7736" } ], "weight": 0.0 }, { "disease_id": "DOID:8398", "name": "osteoarthritis", "description": "An arthritis that has_material_basis_in worn out cartilage located_in joint.", "url": "https://disease-ontology.org/term/DOID:8398", "evidence": [ { "id": "8398", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8398" } ], "weight": 0.0 }, { "disease_id": "DOID:8549", "name": "chronic ulcer of skin", "description": "", "url": "https://disease-ontology.org/term/DOID:8549", "evidence": [ { "id": "8549", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8549" } ], "weight": 0.0 }, { "disease_id": "DOID:8577", "name": "ulcerative colitis", "description": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.", "url": "https://disease-ontology.org/term/DOID:8577", "evidence": [ { "id": "8577", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8577" } ], "weight": 0.0 }, { "disease_id": "DOID:8634", "name": "prostate carcinoma in situ", "description": "An in situ carcinoma that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:8634", "evidence": [ { "id": "8634", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8634" } ], "weight": 0.0 }, { "disease_id": "DOID:8683", "name": "myeloid sarcoma", "description": "", "url": "https://disease-ontology.org/term/DOID:8683", "evidence": [ { "id": "8683", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8683" } ], "weight": 0.0 }, { "disease_id": "DOID:8692", "name": "myeloid leukemia", "description": "A leukemia that is located_in myeloid tissue.", "url": "https://disease-ontology.org/term/DOID:8692", "evidence": [ { "id": "8692", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8692" } ], "weight": 0.0 }, { "disease_id": "DOID:8717", "name": "decubitus ulcer", "description": "A chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.", "url": "https://disease-ontology.org/term/DOID:8717", "evidence": [ { "id": "8717", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8717" } ], "weight": 0.0 }, { "disease_id": "DOID:8719", "name": "in situ carcinoma", "description": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues.", "url": "https://disease-ontology.org/term/DOID:8719", "evidence": [ { "id": "8719", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8719" } ], "weight": 0.0 }, { "disease_id": "DOID:8725", "name": "vascular dementia", "description": "A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.", "url": "https://disease-ontology.org/term/DOID:8725", "evidence": [ { "id": "8725", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8725" } ], "weight": 0.0 }, { "disease_id": "DOID:8778", "name": "Crohn's disease", "description": "An intestinal disease that involves inflammation located_in intestine.", "url": "https://disease-ontology.org/term/DOID:8778", "evidence": [ { "id": "8778", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8778" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 }, { "disease_id": "DOID:8991", "name": "cervix uteri carcinoma in situ", "description": "An uterus carcinoma in situ that is located_in the uterine cervix.", "url": "https://disease-ontology.org/term/DOID:8991", "evidence": [ { "id": "8991", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8991" } 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[ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "M9MS30-1" }, { "uniprot_canonical_ac": "M9MSL3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "M9MSL3", "url": "https://www.uniprot.org/uniprotkb/M9MSL3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 836, "chemical_mass": 91903.0, "gene_names": "Hsp110;0041/12;02;0318/20;12;1342/17;1348/02;13;1485/13;17;20;BEST:LD32772;CG6603;Dmel\\CG6603;Dmel_CG6603;HSC-70cb;HSC-70;HSC70cb;HSC70;HSP110-1;HSP110;Hsc70CB;Hsc70Cb;Hsc70cb;Hsc70;Hsp110;LD32772;anon-WO0118547.302;dHsp110;hsc70Cb;hsc70cb;l(3)00082;l(3)07621;l(3)134217;l(3)148513;l(3)70Ca;l(3)70Cb;l(3)S134217;l(3)S134802;l(3)S148513", "protein_name": "", "disease": [ { "disease_id": "DOID:11394", "name": "adult respiratory distress syndrome", "description": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.", "url": "https://disease-ontology.org/term/DOID:11394", "evidence": [ { "id": "11394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11394" } ], "weight": 0.0 }, { "disease_id": "DOID:12140", "name": "Chagas disease", "description": "A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.", "url": "https://disease-ontology.org/term/DOID:12140", "evidence": [ { "id": "12140", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12140" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:8577", "name": "ulcerative colitis", "description": "A colitis that is 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"name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "M9NFS2", "url": "https://www.uniprot.org/uniprotkb/M9NFS2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 44, "chemical_mass": 4969.0, "gene_names": "Dmel\\CG43147;CG43147;Dmel\\CG43147;Dmel_CG43147;lincRNA.541", "protein_name": "Seminal fluid protein", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "M9NFS2-1" }, { "uniprot_canonical_ac": "M9NG60-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "M9NG60", "url": "https://www.uniprot.org/uniprotkb/M9NG60" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 43, "chemical_mass": 4634.0, "gene_names": "Dmel\\CG43407;CG43407;Dmel\\CG43407;Dmel_CG43407", "protein_name": "", "disease": [], 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"evidence": [ { "database": "UniProtKB", "id": "O46052", "url": "https://www.uniprot.org/uniprotkb/O46052" } ], "pmid": "" }, { "name": "sarcomere", "id": "GO:0030017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "evidence": [ { "database": "UniProtKB", "id": "O46052", "url": "https://www.uniprot.org/uniprotkb/O46052" } ], "pmid": "" } ], "biological_process": [ { "name": "positive regulation of Rho protein signal transduction", "id": "GO:0035025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", "evidence": [ { "database": "UniProtKB", "id": "O46052", "url": "https://www.uniprot.org/uniprotkb/O46052" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O46052", "url": "https://www.uniprot.org/uniprotkb/O46052" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": 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"site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 264, "start_aa": "Thr", "end_pos": 264, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr264", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] }, { "uniprot_canonical_ac": "O46052-1", "start_pos": "369", "end_pos": "369", "site_lbl": "Thr369", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 369, "start_aa": "Thr", "end_pos": 369, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr369", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "O46052-1" }, { 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"O46070-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O46070", "url": "https://www.uniprot.org/uniprotkb/O46070" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 434, "chemical_mass": 46793.0, "gene_names": "anon-WO03040301.165;CG2865;Dmel\\CG2865;Dmel_CG2865;EG:25E8.4;anon-WO03040301.165", "protein_name": "SERTA domain-containing protein", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "O46070-1" }, { "uniprot_canonical_ac": "O46094-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O46094", "url": "https://www.uniprot.org/uniprotkb/O46094" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 850, "chemical_mass": 97530.0, "gene_names": "Ocrl;CG3573;Dmel\\CG3573;Dmel_CG3573;EG:86E4.5;OCRL;Ocrl;dOCRL;dOcrl;docrl;ocrl", "protein_name": "inositol-polyphosphate 5-phosphatase", "disease": [ { "disease_id": "DOID:0081454", "name": "Dent disease 2", "description": "A Dent disease that is characterized by low molecular weight proteinuria and other features of Fanconi syndrome but typically do not include proximal renal tubular acidosis and that has_material_basis_in mutation in the OCRL gene on chromosome Xq26.", "url": "https://disease-ontology.org/term/DOID:0081454", "evidence": [ { "id": "0081454", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081454" } ], "weight": 0.0 }, { "disease_id": "DOID:1056", "name": "oculocerebrorenal syndrome", "description": "A syndrome that has_material_basis_in mutation in the OCRL gene on chromosome Xq26 and that is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the 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} ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O46094", "url": "https://www.uniprot.org/uniprotkb/O46094" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "O46094", "url": "https://www.uniprot.org/uniprotkb/O46094" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "O46094", "url": "https://www.uniprot.org/uniprotkb/O46094" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O46094", "url": "https://www.uniprot.org/uniprotkb/O46094" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", 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BMP signaling pathway", "id": "GO:0030513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030513", "evidence": [ { "database": "UniProtKB", "id": "Q0E9E0", "url": "https://www.uniprot.org/uniprotkb/Q0E9E0" } ], "pmid": "" }, { "name": "determination of adult lifespan", "id": "GO:0008340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "evidence": [ { "database": "UniProtKB", "id": "Q0E9E0", "url": "https://www.uniprot.org/uniprotkb/Q0E9E0" } ], "pmid": "" }, { "name": "germ-line stem cell population maintenance", "id": "GO:0030718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030718", "evidence": [ { "database": "UniProtKB", "id": "Q0E9E0", "url": "https://www.uniprot.org/uniprotkb/Q0E9E0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q0E9E0-1" }, { "uniprot_canonical_ac": "Q0KHZ2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KHZ2", "url": 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"taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KIB0", "url": "https://www.uniprot.org/uniprotkb/Q0KIB0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 1689, "chemical_mass": 181555.0, "gene_names": "side-III;34113;CG10989;CG14677;CG14678;CG34113;CT34460;Dm_3R:9314;Dmel\\CG34113;Dmel_CG34113;side-III", "protein_name": "", "disease": [], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q0KIB0", "url": "https://www.uniprot.org/uniprotkb/Q0KIB0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q0KIB0-1" }, { "uniprot_canonical_ac": "Q0KIF2-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q0KIF2", "url": "https://www.uniprot.org/uniprotkb/Q0KIF2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 899, "chemical_mass": 102769.0, "gene_names": "Ekar;CG9935;CT36399;DmelCG9935;Dmel\\CG9935;Dmel_CG9935;Ekar;ekar", "protein_name": "", "disease": [], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q0KIF2", "url": "https://www.uniprot.org/uniprotkb/Q0KIF2" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "Q0KIF2", "url": "https://www.uniprot.org/uniprotkb/Q0KIF2" } ], "pmid": "" } ], "molecular_function": [ { "name": "ligand-gated monoatomic ion channel activity", "id": "GO:0015276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015276", "evidence": [ { "database": "UniProtKB", "id": "Q0KIF2", "url": 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"Thr829", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 829, "start_aa": "Thr", "end_pos": 829, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr829", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ] } ] } ], "record_id": "Q0KIF2-1" }, { "uniprot_canonical_ac": "Q24050-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q24050", "url": "https://www.uniprot.org/uniprotkb/Q24050" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 262, "chemical_mass": 28883.0, "gene_names": 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material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. 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"Fer1HCH;1HCH;BEST:LD36673;CG2216;Dmel\\CG2216;Dmel_CG2216;FER1HCH;FER1;Fe1HCH;Fer-L;Fer1HCH;Fer1HC;Fer1H;Fer1;FerHCH;HCH;T21;T9;fer1HCH;fer1hch;fer1;l(3)00451;l(3)j10B4", "protein_name": "Ferritin heavy chain", "disease": [ { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": 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{ "database": "UniProtKB", "id": "Q7KS77", "url": "https://www.uniprot.org/uniprotkb/Q7KS77" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 479, "chemical_mass": 52207.0, "gene_names": "lbe;CG6545;Dmel\\CG6545;Dmel_CG6545;Hox11-D125;Lbe;Lb;NK?;lbe;lb", "protein_name": "", "disease": [ { "disease_id": "DOID:0060731", "name": "congenital central hypoventilation syndrome", "description": "An autonomic nervous system disease characterized by reduced responsiveness of the respiratory center to carbon dioxide, diminished pupillary light responses, and other symptoms related to defects in the autonomic nervous system and that has_material_basis_in most commonly heterozygous mutation in the PHOX2B gene on chromosome 4p13 and less frequently mutations in the RET, GDNF, EDN3, BDNF, or ASCL1 genes.", "url": "https://disease-ontology.org/term/DOID:0060731", "evidence": [ { "id": "0060731", "database": "AGR", "url": 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"common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 648, "chemical_mass": 70531.0, "gene_names": "Bsg;10;135/10;BSG;BcDNA:GH21853;Bsg;CG31605;Dmel\\CG31605;Dmel_CG31605;NP6293;basigin;bsg;gel;l(2)06243;l(2)SH1217;l(2)SH2 1217;l(2)k06338;l(2)k09030;l(2)k13638;l(2)k14308;ms(2)08318", "protein_name": "", "disease": [ { "disease_id": "DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells.", "url": "https://disease-ontology.org/term/DOID:2671", "evidence": [ { "id": "2671", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ], "weight": 0.0 }, { "disease_id": "DOID:2871", "name": "endometrial carcinoma", "description": "A endometrial cancer that is located_in the tissue lining the uterus.", "url": "https://disease-ontology.org/term/DOID:2871", "evidence": [ { "id": "2871", "database": "AGR", "url": 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"evidence": [ { "database": "UniProtKB", "id": "Q9VCN7", "url": "https://www.uniprot.org/uniprotkb/Q9VCN7" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 915, "chemical_mass": 98738.0, "gene_names": "orb;151666_s_at;CG10868;Dmel\\CG10868;Dmel_CG10868;ORB1;ORB;Oo18;Orb1;Orb;fs(3)00107;oo18;orb", "protein_name": "", "disease": [ { "disease_id": "DOID:10762", "name": "portal hypertension", "description": "", "url": "https://disease-ontology.org/term/DOID:10762", "evidence": [ { "id": "10762", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10762" } ], "weight": 0.0 }, { "disease_id": "DOID:12236", "name": "primary biliary cholangitis", "description": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.", "url": "https://disease-ontology.org/term/DOID:12236", "evidence": [ { "id": "12236", "database": "AGR", "url": 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fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 257, "chemical_mass": 29294.0, "gene_names": "Dmel\\CG31473;CG2649;CG31473;Dmel\\CG31473;Dmel_CG31473", "protein_name": "pyridoxal 5'-phosphate synthase", "disease": [], "molecular_function": [ { "name": "FMN binding", "id": "GO:0010181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010181", "evidence": [ { "database": "UniProtKB", "id": "Q8INR5", "url": "https://www.uniprot.org/uniprotkb/Q8INR5" } ], "pmid": "" }, { "name": "pyridoxamine phosphate oxidase activity", "id": "GO:0004733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004733", "evidence": [ { "database": "UniProtKB", "id": "Q8INR5", "url": "https://www.uniprot.org/uniprotkb/Q8INR5" } ], "pmid": "" } ], "biological_process": [ { "name": "pyridoxine biosynthetic process", "id": "GO:0008615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008615", "evidence": [ { "database": "UniProtKB", "id": "Q8INR5", "url": 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"evidence": [ { "database": "UniProtKB", "id": "Q8INT0", "url": "https://www.uniprot.org/uniprotkb/Q8INT0" } ], "pmid": "" } ], "molecular_function": [ { "name": "N-acetyltransferase activity", "id": "GO:0008080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008080", "evidence": [ { "database": "UniProtKB", "id": "Q8INT0", "url": "https://www.uniprot.org/uniprotkb/Q8INT0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8INT0-1" }, { "uniprot_canonical_ac": "Q8IP15-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IP15", "url": "https://www.uniprot.org/uniprotkb/Q8IP15" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 155, "chemical_mass": 18451.0, "gene_names": "Dmel\\CG31807;CG31807;Dmel\\CG31807;Dmel_CG31807", "protein_name": "RING-type domain-containing protein", "disease": [], 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"pmid": "" } ], "biological_process": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q8IP15", "url": "https://www.uniprot.org/uniprotkb/Q8IP15" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "Q8IP15", "url": "https://www.uniprot.org/uniprotkb/Q8IP15" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8IP15-1" }, { "uniprot_canonical_ac": "Q8IP27-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IP27", "url": "https://www.uniprot.org/uniprotkb/Q8IP27" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 62, "chemical_mass": 6432.0, "gene_names": 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"Q8IP52", "url": "https://www.uniprot.org/uniprotkb/Q8IP52" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8IP52-1" }, { "uniprot_canonical_ac": "Q8IP90-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IP90", "url": "https://www.uniprot.org/uniprotkb/Q8IP90" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 810, "chemical_mass": 88271.0, "gene_names": "bru1;ARET;Aret;BcDNA:GM15173;Bru1;Bruno;Bru;CG31762;CG6319;Dm Bru;Dmel\\CG31762;Dmel_CG31762;NEST:bs01g04;NEST:bs34h11;aret/bruno1;aret;arrest/Bruno;bru-1;bru1;bruno1;bruno;bru;ms(2)01284", "protein_name": "", "disease": [ { "disease_id": "DOID:0070383", "name": "developmental and epileptic encephalopathy 97", "description": "A developmental and epileptic encephalopathy characterized by onset of seizures in the first months of life that 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"biomarkers": [], "sites": [], "record_id": "Q8IRY5-1" }, { "uniprot_canonical_ac": "Q8IRZ3-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8IRZ3", "url": "https://www.uniprot.org/uniprotkb/Q8IRZ3" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 533, "chemical_mass": 59105.0, "gene_names": "Sdic3;CG32823;CG46275;CG46276;Dmel\\CG32823;Dmel\\CG46275;Dmel\\CG46276;Dmel_CG32823;Dmel_CG46275;Dmel_CG46276;Sdic3;Sdic:CG32823;SdicA;SdicB;Sdic", "protein_name": "", "disease": [ { "disease_id": "DOID:0070296", "name": "autosomal recessive primary microcephaly", "description": "A primary microcephaly characterized by microcephaly present at birth, where the brain is small but has normal architecture, and nonprogressive mental retardation that has_material_basis_in an autosomal recessive mutation.", "url": 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7227, "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 241, "chemical_mass": 26535.0, "gene_names": "Rpi;CG30410;CG9872;Dmel\\CG30410;Dmel_CG30410;Rpi;rpi", "protein_name": "ribose-5-phosphate isomerase", "disease": [], "molecular_function": [ { "name": "ribose-5-phosphate isomerase activity", "id": "GO:0004751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004751", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" } ], "biological_process": [ { "name": "D-ribose metabolic process", "id": "GO:0006014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006014", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" }, { "name": "pentose-phosphate shunt, non-oxidative branch", "id": "GO:0009052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009052", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8MLS2", "url": "https://www.uniprot.org/uniprotkb/Q8MLS2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8MLS2-1" }, { "uniprot_canonical_ac": "Q8MLT8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8MLT8", "url": "https://www.uniprot.org/uniprotkb/Q8MLT8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 275, "chemical_mass": 31490.0, "gene_names": "Dmel\\CG30278;CG30278;CG3387;Dmel\\CG30278;Dmel_CG30278", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8MLT8-1" }, { "uniprot_canonical_ac": "Q8MLW5-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8MLW5", "url": "https://www.uniprot.org/uniprotkb/Q8MLW5" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 566, "chemical_mass": 62288.0, "gene_names": 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"Q8MLW5", "url": "https://www.uniprot.org/uniprotkb/Q8MLW5" } ], "pmid": "" }, { "name": "glucose-6-phosphate transport", "id": "GO:0015760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015760", "evidence": [ { "database": "UniProtKB", "id": "Q8MLW5", "url": "https://www.uniprot.org/uniprotkb/Q8MLW5" } ], "pmid": "" } ], "molecular_function": [ { "name": "glucose 6-phosphate:phosphate antiporter activity", "id": "GO:0061513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061513", "evidence": [ { "database": "UniProtKB", "id": "Q8MLW5", "url": "https://www.uniprot.org/uniprotkb/Q8MLW5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q8MLW5-1" }, { "uniprot_canonical_ac": "Q8MMD0-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q8MMD0", "url": "https://www.uniprot.org/uniprotkb/Q8MMD0" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 126, "chemical_mass": 14013.0, "gene_names": "BcDNA:RH04491;BcDNA:RH04491;CG30423;Dmel\\CG30423;Dmel_CG30423", "protein_name": "Leptin receptor gene-related protein", "disease": [], "molecular_function": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q8MMD0", "url": "https://www.uniprot.org/uniprotkb/Q8MMD0" } ], "pmid": "" } ], "cellular_component": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q8MMD0", "url": "https://www.uniprot.org/uniprotkb/Q8MMD0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q8MMD0", "url": "https://www.uniprot.org/uniprotkb/Q8MMD0" } ], "pmid": "" }, { "name": "membrane", 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"Snp;CG11478;CG30327;CG42257;CG44248;CG6393;Dmel\\CG44248;Snp", "protein_name": "3'-5' exonuclease Snipper", "disease": [], "molecular_function": [ { "name": "single-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008310", "evidence": [ { "database": "UniProtKB", "id": "Q95RQ4", "url": "https://www.uniprot.org/uniprotkb/Q95RQ4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q95RQ4", "url": "https://www.uniprot.org/uniprotkb/Q95RQ4" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q95RQ4", "url": "https://www.uniprot.org/uniprotkb/Q95RQ4" } ], "pmid": "" }, { "name": "double-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008311", "url": 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from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000467", "evidence": [ { "database": "UniProtKB", "id": "Q95RQ4", "url": "https://www.uniprot.org/uniprotkb/Q95RQ4" } ], "pmid": "" }, { "name": "negative regulation of regulatory ncRNA-mediated heterochromatin formation", "id": "GO:0060906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060906", "evidence": [ { "database": "UniProtKB", "id": "Q95RQ4", "url": "https://www.uniprot.org/uniprotkb/Q95RQ4" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "Q95RQ4-1" }, { "uniprot_canonical_ac": "Q9I7H8-1", "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9I7H8", "url": "https://www.uniprot.org/uniprotkb/Q9I7H8" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "length": 308, 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