{
    "disease_id": "DOID:0110913",
    "recommended_name": {
        "id": "DOID:0110913",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110913",
        "name": "adult hypophosphatasia",
        "description": "A hypophosphatasia that has_material_basis_in a heterozygous or compound heterozygous mutation of the ALPL gene on chromosome 1p36.12."
    },
    "synonyms": [
        {
            "id": "DOID:0110913",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110913",
            "name": "mild hypophosphatasia",
            "description": ""
        },
        {
            "id": "MONDO:1010154",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:1010154",
            "name": "adult hypophosphatasia",
            "description": "Adult hypophosphatasia (A-HPP) is a mildform of hypophosphatasia characterized by osteomalacia, chondrocalcinosis, osteoarthropathy, stress fractures duringmiddle age, and dental anomalies."
        },
        {
            "id": "MONDO:1010154",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:1010154",
            "name": "adult hypophosphatasia",
            "description": ""
        },
        {
            "id": "MONDO:1010154",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:1010154",
            "name": "hypophosphatasia of adults",
            "description": ""
        },
        {
            "id": "MIM:146300",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/146300",
            "name": "Hypophosphatasia",
            "description": "Hypophosphatasia"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110913"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110913",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110913",
            "categories": []
        },
        {
            "id": "MONDO:1010154",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:1010154",
            "categories": []
        },
        {
            "id": "MIM:146300",
            "database": "MIM",
            "url": "https://www.omim.org/entry/146300",
            "categories": []
        }
    ],
    "proteins": [
        {
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            "uniprot_ac": "F1Q5B5",
            "uniprot_id": "F1Q5B5_DANRE",
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                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
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                    "type": "synonym"
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                },
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                    "type": "synonym"
                },
                {
                    "name": "zgc:56672",
                    "type": "synonym"
                }
            ],
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                    "id": "0110913",
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                }
            ]
        },
        {
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            "uniprot_ac": "P09242",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                    "type": "synonym"
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                    "type": "synonym"
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                    "type": "synonym"
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                    "type": "synonym"
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            ],
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                    "name": "Alpl",
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                }
            ],
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                    "name": "Alkaline phosphatase, tissue-nonspecific isozyme",
                    "type": "recommended"
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                    "type": "synonym"
                },
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                    "type": "synonym"
                },
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                    "type": "synonym"
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                    "type": "synonym"
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                    "name": "TNSALP",
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                    "type": "synonym"
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                    "type": "synonym"
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                    "type": "synonym"
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                    "name": "liver/bone/kidney-type alkaline phosphatase",
                    "type": "synonym"
                },
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                    "type": "synonym"
                },
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                    "name": "phosphocreatine phosphatase",
                    "type": "synonym"
                },
                {
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                    "type": "synonym"
                },
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                    "name": "tissue-nonspecific ALP",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "ALPL",
                    "type": "recommended"
                },
                {
                    "name": "ALPL",
                    "type": "synonym"
                },
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                    "type": "synonym"
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                    "type": "synonym"
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                    "id": "0110913",
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                }
            ]
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                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
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                    "name": "Rattus norvegicus",
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                {
                    "name": "Alp5-PA",
                    "type": "synonym"
                },
                {
                    "name": "CG10827-PA",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 5",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp5",
                    "type": "recommended"
                },
                {
                    "name": "Alp5",
                    "type": "synonym"
                },
                {
                    "name": "CG10827",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG10827",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG10827",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VXS8-1",
            "uniprot_ac": "Q9VXS8",
            "uniprot_id": "Q9VXS8_DROME",
            "refseq_ac": "NP_573047",
            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp11-PA",
                    "type": "synonym"
                },
                {
                    "name": "CG8105-PA",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 11",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp11",
                    "type": "recommended"
                },
                {
                    "name": "Alp11",
                    "type": "synonym"
                },
                {
                    "name": "CG8105",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8105",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8105",
                    "type": "synonym"
                },
                {
                    "name": "FBgn0030661",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W274-1",
            "uniprot_ac": "Q9W274",
            "uniprot_id": "Q9W274_DROME",
            "refseq_ac": "NP_611654",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp2-PA",
                    "type": "synonym"
                },
                {
                    "name": "CG3290-PA",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp2",
                    "type": "recommended"
                },
                {
                    "name": "Alp2",
                    "type": "synonym"
                },
                {
                    "name": "Aph-2",
                    "type": "synonym"
                },
                {
                    "name": "CG3290",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3290",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3290",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W274-1",
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                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W275-1",
            "uniprot_ac": "Q9W275",
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            "refseq_ac": "NP_611653",
            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp7-PA",
                    "type": "synonym"
                },
                {
                    "name": "CG3292-PA",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 7",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp7",
                    "type": "recommended"
                },
                {
                    "name": "Alp7",
                    "type": "synonym"
                },
                {
                    "name": "CG3292",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3292",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3292",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W275-1",
            "evidence": [
                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "M9PD70-1",
            "uniprot_ac": "M9PD70",
            "uniprot_id": "M9PD70_DROME",
            "refseq_ac": "NP_001262159",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp1-PB",
                    "type": "synonym"
                },
                {
                    "name": "CG5656-PB",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 1, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase-1",
                    "type": "synonym"
                },
                {
                    "name": "larval alkaline phosphatase",
                    "type": "synonym"
                },
                {
                    "name": "pupal alkaline phosphatase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp1",
                    "type": "recommended"
                },
                {
                    "name": "APH",
                    "type": "synonym"
                },
                {
                    "name": "Alp1",
                    "type": "synonym"
                },
                {
                    "name": "Aph-1",
                    "type": "synonym"
                },
                {
                    "name": "Aph",
                    "type": "synonym"
                },
                {
                    "name": "CG5656",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5656",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5656",
                    "type": "synonym"
                },
                {
                    "name": "l-Aph",
                    "type": "synonym"
                },
                {
                    "name": "p-Aph",
                    "type": "synonym"
                }
            ],
            "record_id": "M9PD70-1",
            "evidence": [
                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W273-1",
            "uniprot_ac": "Q9W273",
            "uniprot_id": "Q9W273_DROME",
            "refseq_ac": "NP_001286709",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Alkaline phosphatase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp8-PB",
                    "type": "synonym"
                },
                {
                    "name": "CG3264-PB",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 8, isoform B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp8",
                    "type": "recommended"
                },
                {
                    "name": "Alp8",
                    "type": "synonym"
                },
                {
                    "name": "CG3264",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3264",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3264",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W273-1",
            "evidence": [
                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q24238-1",
            "uniprot_ac": "Q24238",
            "uniprot_id": "APH4_DROME",
            "refseq_ac": "NP_524601",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Alkaline phosphatase 4",
                    "type": "recommended"
                },
                {
                    "name": "3.1.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Alp4-PA",
                    "type": "synonym"
                },
                {
                    "name": "CG1462-PA",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase 4, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "alkaline phosphatase-4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Alp4",
                    "type": "recommended"
                },
                {
                    "name": "Alp4",
                    "type": "synonym"
                },
                {
                    "name": "Aph-4",
                    "type": "synonym"
                },
                {
                    "name": "CG1462",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG1462",
                    "type": "synonym"
                },
                {
                    "name": "aph-4",
                    "type": "synonym"
                },
                {
                    "name": "l(3)07028",
                    "type": "synonym"
                },
                {
                    "name": "pMY51",
                    "type": "synonym"
                }
            ],
            "record_id": "Q24238-1",
            "evidence": [
                {
                    "id": "0110913",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110913"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110913"
}