{
    "disease_id": "DOID:0110098",
    "recommended_name": {
        "id": "DOID:0110098",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110098",
        "name": "atopic dermatitis 2",
        "description": "An atopic dermatitis conferred by variation in the FLG gene on chromosome 1q21."
    },
    "synonyms": [
        {
            "id": "DOID:0110098",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110098",
            "name": "ATOD2",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "dermatitis, atopic, 2",
            "description": "An inherited susceptibility or predisposition to developing atopic dermatitis in which the cause of the disease is a mutation in the FLG gene."
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "ATOD2",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "FLG atopic eczema",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "atopic dermatitis type 2",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "atopic eczema caused by mutation in FLG",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "dermatitis, Atopic, type 2",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "dermatitis, atopic, susceptibility to, 2",
            "description": ""
        },
        {
            "id": "MONDO:0011596",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "name": "dermatitis, ATOPIC, 2",
            "description": ""
        },
        {
            "id": "MIM:605803",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/605803",
            "name": "Dermatitis atopic 2",
            "description": "Dermatitis atopic 2"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110098"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110098",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110098",
            "categories": []
        },
        {
            "id": "MONDO:0011596",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011596",
            "categories": []
        },
        {
            "id": "MIM:605803",
            "database": "MIM",
            "url": "https://www.omim.org/entry/605803",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P11088-1",
            "uniprot_ac": "P11088",
            "uniprot_id": "FILA_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Filaggrin",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "Flg",
                    "type": "recommended"
                }
            ],
            "record_id": "P11088-1",
            "evidence": [
                {
                    "id": "0110098",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110098"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20930-1",
            "uniprot_ac": "P20930",
            "uniprot_id": "FILA_HUMAN",
            "refseq_ac": "NP_002007",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Filaggrin",
                    "type": "recommended"
                },
                {
                    "name": "epidermal filaggrin",
                    "type": "synonym"
                },
                {
                    "name": "filaggrin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FLG",
                    "type": "recommended"
                },
                {
                    "name": "ATOD2",
                    "type": "synonym"
                },
                {
                    "name": "FLG-1",
                    "type": "synonym"
                },
                {
                    "name": "FLG1",
                    "type": "synonym"
                },
                {
                    "name": "FLG",
                    "type": "synonym"
                }
            ],
            "record_id": "P20930-1",
            "evidence": [
                {
                    "id": "605803",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/605803"
                },
                {
                    "id": "0110098",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110098"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P07092-1",
            "uniprot_ac": "P07092",
            "uniprot_id": "GDN_RAT",
            "refseq_ac": "NP_062070",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Glia-derived nexin",
                    "type": "recommended"
                },
                {
                    "name": "Clozapine Regulated Gene",
                    "type": "synonym"
                },
                {
                    "name": "GDN",
                    "type": "synonym"
                },
                {
                    "name": "Glia-derived nexin/protease nexin I",
                    "type": "synonym"
                },
                {
                    "name": "PI-7",
                    "type": "synonym"
                },
                {
                    "name": "PN-1",
                    "type": "synonym"
                },
                {
                    "name": "Peptidase inhibitor 7",
                    "type": "synonym"
                },
                {
                    "name": "Protease nexin 1",
                    "type": "synonym"
                },
                {
                    "name": "Protease nexin I",
                    "type": "synonym"
                },
                {
                    "name": "Serpin E2",
                    "type": "synonym"
                },
                {
                    "name": "glia-derived nexin / preotease nexin I",
                    "type": "synonym"
                },
                {
                    "name": "glia-derived nexin precursor",
                    "type": "synonym"
                },
                {
                    "name": "peptidase inhibitor 7",
                    "type": "synonym"
                },
                {
                    "name": "plasminogen activator inhibitor type 1",
                    "type": "synonym"
                },
                {
                    "name": "protease nexin 1",
                    "type": "synonym"
                },
                {
                    "name": "protease nexin PN-1",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) peptidase inhibitor, clade E, member 2",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) proteinase inhibitor, clade E, member 2",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 4",
                    "type": "synonym"
                },
                {
                    "name": "serpin E2",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade E, member 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Serpine2",
                    "type": "recommended"
                },
                {
                    "name": "CRG",
                    "type": "synonym"
                },
                {
                    "name": "Gdnpn1",
                    "type": "synonym"
                },
                {
                    "name": "PI-7",
                    "type": "synonym"
                },
                {
                    "name": "Pi7",
                    "type": "synonym"
                },
                {
                    "name": "Pn-1",
                    "type": "synonym"
                },
                {
                    "name": "Pn1",
                    "type": "synonym"
                },
                {
                    "name": "Serpine2",
                    "type": "synonym"
                },
                {
                    "name": "Spin4",
                    "type": "synonym"
                }
            ],
            "record_id": "P07092-1",
            "evidence": [
                {
                    "id": "0110098",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110098"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33260-1",
            "uniprot_ac": "P33260",
            "uniprot_id": "CP2CI_HUMAN",
            "refseq_ac": "NP_000763",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytochrome P450 2C18",
                    "type": "recommended"
                },
                {
                    "name": "(S)-mephenytoin hydroxylase associated cytochrome P450",
                    "type": "synonym"
                },
                {
                    "name": "1.14.14.1",
                    "type": "synonym"
                },
                {
                    "name": "CYPIIC18",
                    "type": "synonym"
                },
                {
                    "name": "Cytochrome P450-6b/29c",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450 2C18 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450 2C18",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, family 2, subfamily C, polypeptide 18",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450-6B/29C",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein-linked monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "microsomal monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "unspecific monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CYP2C18",
                    "type": "recommended"
                },
                {
                    "name": "CPCI",
                    "type": "synonym"
                },
                {
                    "name": "CYP2C17",
                    "type": "synonym"
                },
                {
                    "name": "CYP2C18",
                    "type": "synonym"
                },
                {
                    "name": "CYP2C",
                    "type": "synonym"
                },
                {
                    "name": "P450-6B/29C",
                    "type": "synonym"
                },
                {
                    "name": "P450IIC17",
                    "type": "synonym"
                }
            ],
            "record_id": "P33260-1",
            "evidence": [
                {
                    "id": "0110098",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110098"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110098"
}