{
    "disease_id": "DOID:0080933",
    "recommended_name": {
        "id": "DOID:0080933",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080933",
        "name": "immunoglobulin light chain amyloidosis",
        "description": "An amyloidosis that is characterized by misfolded and aggregated amyloidogenic immunoglobulin light chains produced by marrow clonal plasma cells."
    },
    "synonyms": [
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "AL amyloidosis",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Amyloidosis primary systemic",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Light chain amyloidosis",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Primary AL amyloidosis",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Primary systemic AL amyloidosis",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Primary systemic amyloidosis",
            "description": ""
        },
        {
            "id": "DOID:0080933",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "name": "Systemic AL amyloidsis",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080933"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080933",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080933",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P28862-1",
            "uniprot_ac": "P28862",
            "uniprot_id": "MMP3_MOUSE",
            "refseq_ac": "NP_034939",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Stromelysin-1",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.17",
                    "type": "synonym"
                },
                {
                    "name": "EMS-2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-3",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-3",
                    "type": "synonym"
                },
                {
                    "name": "SL-1",
                    "type": "synonym"
                },
                {
                    "name": "Transin-1",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 3",
                    "type": "synonym"
                },
                {
                    "name": "progelatinase",
                    "type": "synonym"
                },
                {
                    "name": "stromelysin-1 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "stromelysin-1",
                    "type": "synonym"
                },
                {
                    "name": "transin-1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Mmp3",
                    "type": "recommended"
                },
                {
                    "name": "EMS-2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-3",
                    "type": "synonym"
                },
                {
                    "name": "Mmp3",
                    "type": "synonym"
                },
                {
                    "name": "SL-1",
                    "type": "synonym"
                },
                {
                    "name": "SLN-1",
                    "type": "synonym"
                },
                {
                    "name": "SLN1",
                    "type": "synonym"
                },
                {
                    "name": "STR-1",
                    "type": "synonym"
                },
                {
                    "name": "Stmy1",
                    "type": "synonym"
                },
                {
                    "name": "Str1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080933",
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                }
            ]
        },
        {
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            "uniprot_ac": "Q9EPL6",
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            "refseq_ac": "",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Interstitial collagenase B",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.7",
                    "type": "synonym"
                },
                {
                    "name": "MMP-1b",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-1b",
                    "type": "synonym"
                },
                {
                    "name": "Mcol-B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp1b",
                    "type": "recommended"
                },
                {
                    "name": "McolB",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080933",
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                }
            ]
        },
        {
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                    "name": "Mus musculus",
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                }
            ],
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                {
                    "name": "72 kDa type IV collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72kD gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72kD type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp2",
                    "type": "recommended"
                },
                {
                    "name": "Clg4a",
                    "type": "synonym"
                },
                {
                    "name": "GelA",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Mmp2",
                    "type": "synonym"
                }
            ],
            "record_id": "P33434-1",
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                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9EPL5-1",
            "uniprot_ac": "Q9EPL5",
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            "refseq_ac": "NP_114395",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interstitial collagenase A",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.7",
                    "type": "synonym"
                },
                {
                    "name": "MMP-1a",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-1a",
                    "type": "synonym"
                },
                {
                    "name": "Mcol-A",
                    "type": "synonym"
                },
                {
                    "name": "collagenase-like A",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase A preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 1a (interstitial collagenase)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp1a",
                    "type": "recommended"
                },
                {
                    "name": "MMP-1a",
                    "type": "synonym"
                },
                {
                    "name": "Mcol-A",
                    "type": "synonym"
                },
                {
                    "name": "McolA",
                    "type": "synonym"
                },
                {
                    "name": "Mcola",
                    "type": "synonym"
                },
                {
                    "name": "Mmp1a",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9EPL5-1",
            "evidence": [
                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P03957-1",
            "uniprot_ac": "P03957",
            "uniprot_id": "MMP3_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Stromelysin-1",
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                    "name": "3.4.24.17",
                    "type": "synonym"
                },
                {
                    "name": "MMP-3",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-3",
                    "type": "synonym"
                },
                {
                    "name": "PTR1 protein",
                    "type": "synonym"
                },
                {
                    "name": "SL-1",
                    "type": "synonym"
                },
                {
                    "name": "Transin-1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Mmp3",
                    "type": "recommended"
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            ],
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                {
                    "id": "0080933",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P81563-1",
            "uniprot_ac": "P81563",
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            "refseq_ac": "",
            "glycoprotein": "no",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
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                }
            ],
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                {
                    "name": "Interstitial collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.7",
                    "type": "synonym"
                },
                {
                    "name": "Fibroblast collagenase",
                    "type": "synonym"
                },
                {
                    "name": "MMP-1",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-1",
                    "type": "synonym"
                },
                {
                    "name": "Myocardial collagenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp1",
                    "type": "recommended"
                }
            ],
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                {
                    "id": "0080933",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33436-1",
            "uniprot_ac": "P33436",
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                {
                    "name": "Rattus norvegicus",
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                    "common_name": "Rat",
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                }
            ],
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                    "name": "72 kDa type IV collagenase",
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                {
                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 KDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase precursor",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp2",
                    "type": "recommended"
                },
                {
                    "name": "Mmp2",
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                }
            ],
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                {
                    "id": "0080933",
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                }
            ]
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            "uniprot_canonical_ac": "D3ZRZ2-1",
            "uniprot_ac": "D3ZRZ2",
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                    "name": "Rattus norvegicus",
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                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                    "name": "interstitial collagenase",
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                },
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                    "name": "3.4.24.7",
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                },
                {
                    "name": "interstitial collagenase A-like",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase B precursor",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase B-like",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase B",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 1b (interstitial collagenase)",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Mmp1b",
                    "type": "recommended"
                },
                {
                    "name": "Mmp1b",
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                }
            ],
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                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08253-1",
            "uniprot_ac": "P08253",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                }
            ],
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                {
                    "name": "72 kDa type IV collagenase",
                    "type": "recommended"
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                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "TBE-1",
                    "type": "synonym"
                },
                {
                    "name": "collagenase type IV-A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)",
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                },
                {
                    "name": "matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-II",
                    "type": "synonym"
                },
                {
                    "name": "neutrophil gelatinase",
                    "type": "synonym"
                }
            ],
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                    "name": "MMP2",
                    "type": "recommended"
                },
                {
                    "name": "CLG4A",
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                },
                {
                    "name": "CLG4",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-II",
                    "type": "synonym"
                },
                {
                    "name": "MMP2",
                    "type": "synonym"
                },
                {
                    "name": "MONA",
                    "type": "synonym"
                },
                {
                    "name": "TBE-1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P03956-1",
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            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Interstitial collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.7",
                    "type": "synonym"
                },
                {
                    "name": "Fibroblast collagenase",
                    "type": "synonym"
                },
                {
                    "name": "MMP-1",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-1",
                    "type": "synonym"
                },
                {
                    "name": "fibroblast collagenase",
                    "type": "synonym"
                },
                {
                    "name": "interstitial collagenase isoform 1 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "matrix metallopeptidase 1 (interstitial collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloprotease 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MMP1",
                    "type": "recommended"
                },
                {
                    "name": "CLG",
                    "type": "synonym"
                },
                {
                    "name": "MMP1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08254-1",
            "uniprot_ac": "P08254",
            "uniprot_id": "MMP3_HUMAN",
            "refseq_ac": "NP_002413",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Stromelysin-1",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.17",
                    "type": "synonym"
                },
                {
                    "name": "MMP-3",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-3",
                    "type": "synonym"
                },
                {
                    "name": "SL-1",
                    "type": "synonym"
                },
                {
                    "name": "Transin-1",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 3 (stromelysin 1, progelatinase)",
                    "type": "synonym"
                },
                {
                    "name": "proteoglycanase",
                    "type": "synonym"
                },
                {
                    "name": "stromelysin-1 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "stromelysin-1",
                    "type": "synonym"
                },
                {
                    "name": "transin-1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MMP3",
                    "type": "recommended"
                },
                {
                    "name": "CHDS6",
                    "type": "synonym"
                },
                {
                    "name": "MMP-3",
                    "type": "synonym"
                },
                {
                    "name": "MMP3",
                    "type": "synonym"
                },
                {
                    "name": "SL-1",
                    "type": "synonym"
                },
                {
                    "name": "STMY1",
                    "type": "synonym"
                },
                {
                    "name": "STMY",
                    "type": "synonym"
                },
                {
                    "name": "STR1",
                    "type": "synonym"
                }
            ],
            "record_id": "P08254-1",
            "evidence": [
                {
                    "id": "0080933",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080933"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080933"
}