{
    "disease_id": "DOID:0080826",
    "recommended_name": {
        "id": "DOID:0080826",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080826",
        "name": "nocturnal asthma",
        "description": "A chronic asthma that is characterized by significant decline in pulmonary function and increase of airway inflammation at night. During sleep, recumbent posture causes a reduction in the lung volumes, respiratory muscle tone, and lung compliance. The overnight physiological abnormalities include: increased airway inflammation and decreased steroid responsiveness, increased pulmonary capillary blood volume, functional differences in blood/air volume ratios and mechanical coupling of the parenchyma to the airways."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0080826"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080826",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080826",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1QLY4-1",
            "uniprot_ac": "F1QLY4",
            "uniprot_id": "RORAA_DANRE",
            "refseq_ac": "NP_001103637",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nuclear receptor ROR-alpha A",
                    "type": "recommended"
                },
                {
                    "name": "NR1F1-B",
                    "type": "synonym"
                },
                {
                    "name": "Retinoid-related orphan receptor alpha 2",
                    "type": "synonym"
                },
                {
                    "name": "Retinoid-related orphan receptor-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor alpha 2",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "rora",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "roraa",
                    "type": "recommended"
                },
                {
                    "name": "RORalpha-B",
                    "type": "synonym"
                },
                {
                    "name": "gb:dq017624",
                    "type": "synonym"
                },
                {
                    "name": "rora2",
                    "type": "synonym"
                },
                {
                    "name": "roraa",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QLY4-1",
            "evidence": [
                {
                    "id": "0080826",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1QJF4-1",
            "uniprot_ac": "F1QJF4",
            "uniprot_id": "RORAB_DANRE",
            "refseq_ac": "NP_957361",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nuclear receptor ROR-alpha B",
                    "type": "recommended"
                },
                {
                    "name": "NR1F1-A",
                    "type": "synonym"
                },
                {
                    "name": "RORalpha-A",
                    "type": "synonym"
                },
                {
                    "name": "Retinoid-related orphan receptor alpha 1",
                    "type": "synonym"
                },
                {
                    "name": "Retinoid-related orphan receptor-alpha B",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha B",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor alpha 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor-alpha B",
                    "type": "synonym"
                },
                {
                    "name": "rora1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "rorab",
                    "type": "recommended"
                },
                {
                    "name": "Rora",
                    "type": "synonym"
                },
                {
                    "name": "rora1",
                    "type": "synonym"
                },
                {
                    "name": "rorab",
                    "type": "synonym"
                },
                {
                    "name": "wu:fq24g04",
                    "type": "synonym"
                },
                {
                    "name": "zgc:55954",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QJF4-1",
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                {
                    "id": "0080826",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P51448-1",
            "uniprot_ac": "P51448",
            "uniprot_id": "RORA_MOUSE",
            "refseq_ac": "NP_001276845",
            "glycoprotein": "no",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nuclear receptor ROR-alpha",
                    "type": "recommended"
                },
                {
                    "name": "Nuclear receptor RZR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group F member 1",
                    "type": "synonym"
                },
                {
                    "name": "RAR-related orphan receptor A",
                    "type": "synonym"
                },
                {
                    "name": "Retinoid-related orphan receptor-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor RZR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group F member 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor-alpha",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rora",
                    "type": "recommended"
                },
                {
                    "name": "9530021D13Rik",
                    "type": "synonym"
                },
                {
                    "name": "Nr1f1",
                    "type": "synonym"
                },
                {
                    "name": "ROR1",
                    "type": "synonym"
                },
                {
                    "name": "ROR2",
                    "type": "synonym"
                },
                {
                    "name": "ROR3",
                    "type": "synonym"
                },
                {
                    "name": "Rora",
                    "type": "synonym"
                },
                {
                    "name": "Rzra",
                    "type": "synonym"
                },
                {
                    "name": "nmf267",
                    "type": "synonym"
                },
                {
                    "name": "sg",
                    "type": "synonym"
                },
                {
                    "name": "staggerer",
                    "type": "synonym"
                },
                {
                    "name": "tmgc26",
                    "type": "synonym"
                }
            ],
            "record_id": "P51448-1",
            "evidence": [
                {
                    "id": "0080826",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8BZP8-1",
            "uniprot_ac": "Q8BZP8",
            "uniprot_id": "NPSR1_MOUSE",
            "refseq_ac": "NP_783609",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Neuropeptide S receptor",
                    "type": "recommended"
                },
                {
                    "name": "G protein-coupled receptor 154",
                    "type": "synonym"
                },
                {
                    "name": "G protein-coupled receptor PGR14",
                    "type": "synonym"
                },
                {
                    "name": "neuropeptide S receptor",
                    "type": "synonym"
                },
                {
                    "name": "vasotocin receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Npsr1",
                    "type": "recommended"
                },
                {
                    "name": "9330128H10Rik",
                    "type": "synonym"
                },
                {
                    "name": "GPRA",
                    "type": "synonym"
                },
                {
                    "name": "Gpr154",
                    "type": "synonym"
                },
                {
                    "name": "MVTR",
                    "type": "synonym"
                },
                {
                    "name": "Npsr1",
                    "type": "synonym"
                },
                {
                    "name": "PGR14",
                    "type": "synonym"
                },
                {
                    "name": "Pgr14",
                    "type": "synonym"
                },
                {
                    "name": "VRR1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080826",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ABK0M9J5-1",
            "uniprot_ac": "A0ABK0M9J5",
            "uniprot_id": "A0ABK0M9J5_RAT",
            "refseq_ac": "NP_001414296",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "RAR-related orphan receptor A",
                    "type": "synonym"
                },
                {
                    "name": "RAR-related orphan receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha-like",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rora",
                    "type": "recommended"
                },
                {
                    "name": "Rora",
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                }
            ],
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                {
                    "id": "0080826",
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                }
            ]
        },
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            "uniprot_canonical_ac": "P0C0L6-1",
            "uniprot_ac": "P0C0L6",
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            "refseq_ac": "",
            "glycoprotein": "yes",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Neuropeptide S receptor",
                    "type": "recommended"
                },
                {
                    "name": "G protein-coupled receptor 154",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Npsr1",
                    "type": "recommended"
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                {
                    "name": "Gpr154",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080826",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
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            "uniprot_canonical_ac": "P31396-1",
            "uniprot_ac": "P31396",
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                    "name": "Drosophila melanogaster",
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                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                    "name": "Probable nuclear hormone receptor HR3",
                    "type": "recommended"
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                    "name": "CG33183-PF",
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                    "name": "Hr3-PF",
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                },
                {
                    "name": "Nuclear receptor subfamily 1 group F member 4",
                    "type": "synonym"
                },
                {
                    "name": "complementation group D",
                    "type": "synonym"
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                {
                    "name": "dHR3",
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                {
                    "name": "hormone receptor 3, isoform F",
                    "type": "synonym"
                },
                {
                    "name": "hormone receptor 3",
                    "type": "synonym"
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                {
                    "name": "hormone receptor-like 46",
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                {
                    "name": "hormone receptor-like in 46",
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                    "name": "Hr3",
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                    "name": "12.6",
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                    "name": "2.4",
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                    "name": "CG11823",
                    "type": "synonym"
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                    "name": "CG12208",
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                    "name": "CG33183",
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                    "name": "DHR3",
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                    "name": "Dhr3",
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                    "name": "DmHr3",
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                    "name": "DmRORalpha",
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                    "name": "Dmel\\CG33183",
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                    "name": "Dmel_CG33183",
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                    "name": "D",
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                    "name": "HR3",
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                    "name": "Hr3",
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                {
                    "name": "Hr46",
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                {
                    "name": "NR1F4",
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                    "name": "dHR3",
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                {
                    "name": "dhr3",
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                    "name": "hr46",
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                {
                    "name": "l(2)46CFi",
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                {
                    "name": "l(2)k09242",
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                    "id": "0080826",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
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            "uniprot_canonical_ac": "Q868T3-1",
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                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Cardioacceleratory peptide receptor",
                    "type": "recommended"
                },
                {
                    "name": "CCAP receptor",
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                {
                    "name": "CCAP-R-PC",
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                {
                    "name": "CG33344-PC",
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                },
                {
                    "name": "Crustacean cardioactive peptide receptor",
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                {
                    "name": "cardioacceleratory peptide receptor",
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                {
                    "name": "crustacean cardioactive peptide receptor, isoform C",
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                    "name": "CCAP-R",
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                {
                    "name": "CCAP-R",
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                    "name": "CCAPR",
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                    "name": "CG14547",
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                },
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                    "name": "CG33344",
                    "type": "synonym"
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                    "name": "CG6111",
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                },
                {
                    "name": "Ccap R",
                    "type": "synonym"
                },
                {
                    "name": "CcapR",
                    "type": "synonym"
                },
                {
                    "name": "DCCAPR",
                    "type": "synonym"
                },
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                    "name": "Dmel\\CG33344",
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                },
                {
                    "name": "Dmel_CG33344",
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                },
                {
                    "name": "anon-WO0170980.46",
                    "type": "synonym"
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                {
                    "name": "anon-WO0170980.47",
                    "type": "synonym"
                }
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                    "id": "0080826",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6W5P4-1",
            "uniprot_ac": "Q6W5P4",
            "uniprot_id": "NPSR1_HUMAN",
            "refseq_ac": "NP_001287862",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                    "name": "Neuropeptide S receptor",
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                    "name": "G protein-coupled receptor PGR14",
                    "type": "synonym"
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                {
                    "name": "G protein-coupled receptor for asthma susceptibility",
                    "type": "synonym"
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                {
                    "name": "G-protein coupled receptor 154",
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                },
                {
                    "name": "G-protein coupled receptor PGR14",
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                {
                    "name": "G-protein coupled receptor for asthma susceptibility",
                    "type": "synonym"
                },
                {
                    "name": "neuropeptide S receptor isoform B short",
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                {
                    "name": "vasopressin receptor-related receptor 1",
                    "type": "synonym"
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                    "name": "NPSR1",
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                {
                    "name": "FNSS3",
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                    "name": "GPR154",
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                    "name": "GPRA",
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                    "name": "NPSR",
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                    "name": "PGR14",
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                {
                    "name": "VRR1",
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                    "id": "0080826",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
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        {
            "uniprot_canonical_ac": "P35398-2",
            "uniprot_ac": "P35398",
            "uniprot_id": "RORA_HUMAN",
            "refseq_ac": "NP_002934",
            "glycoprotein": "yes",
            "species": [
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                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nuclear receptor ROR-alpha",
                    "type": "recommended"
                },
                {
                    "name": "Nuclear receptor RZR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group F member 1",
                    "type": "synonym"
                },
                {
                    "name": "RAR-related orphan nuclear receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "RAR-related orphan receptor A",
                    "type": "synonym"
                },
                {
                    "name": "ROR-alpha",
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                {
                    "name": "Retinoid-related orphan receptor-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha isoform c",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor ROR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor RZR-alpha",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group F member 1",
                    "type": "synonym"
                },
                {
                    "name": "retinoic acid receptor-related orphan receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "retinoid-related orphan receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "transcription factor RZR-alpha",
                    "type": "synonym"
                }
            ],
            "gene_names": [
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                    "name": "RORA",
                    "type": "recommended"
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                {
                    "name": "IDDECA",
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                },
                {
                    "name": "NR1F1",
                    "type": "synonym"
                },
                {
                    "name": "ROR1",
                    "type": "synonym"
                },
                {
                    "name": "ROR2",
                    "type": "synonym"
                },
                {
                    "name": "ROR3",
                    "type": "synonym"
                },
                {
                    "name": "RORA",
                    "type": "synonym"
                },
                {
                    "name": "RORa1",
                    "type": "synonym"
                },
                {
                    "name": "RORalpha",
                    "type": "synonym"
                },
                {
                    "name": "RZR-ALPHA",
                    "type": "synonym"
                },
                {
                    "name": "RZRA",
                    "type": "synonym"
                }
            ],
            "record_id": "P35398-2",
            "evidence": [
                {
                    "id": "0080826",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080826"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080826"
}