{
    "disease_id": "DOID:0080746",
    "recommended_name": {
        "id": "DOID:0080746",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080746",
        "name": "Sweet syndrome",
        "description": "A skin disease that is characterized by sudden onset of well defined tender plaques or nodules accompanied by fever, arthralgias, ocular inflammation, headaches and, rarely, oral or genital lesions."
    },
    "synonyms": [
        {
            "id": "DOID:0080746",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080746",
            "name": "Acute Febrile Neutrophilic Dermatosis",
            "description": ""
        },
        {
            "id": "DOID:0080746",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080746",
            "name": "Sweet's syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0011959",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011959",
            "name": "sweet syndrome",
            "description": "Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis) is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques), and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis."
        },
        {
            "id": "MONDO:0011959",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011959",
            "name": "acute febrile neutrophilic dermatosis",
            "description": ""
        },
        {
            "id": "MONDO:0011959",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011959",
            "name": "sweet syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0011959",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011959",
            "name": "Gomm button disease",
            "description": ""
        },
        {
            "id": "MIM:608068",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/608068",
            "name": "Pyrin-associated autoinflammatory disease",
            "description": "Pyrin-associated autoinflammatory disease"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080746"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080746",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080746",
            "categories": []
        },
        {
            "id": "MONDO:0011959",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011959",
            "categories": []
        },
        {
            "id": "MIM:608068",
            "database": "MIM",
            "url": "https://www.omim.org/entry/608068",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AC58HIZ5-1",
            "uniprot_ac": "A0AC58HIZ5",
            "uniprot_id": "A0AC58HIZ5_DANRE",
            "refseq_ac": "XP_073781980",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Zinc-binding protein A33 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "zinc-binding protein A33 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:ch73-54f23.4",
                    "type": "recommended"
                },
                {
                    "name": "si:ch73-54f23.4",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AC58HIZ5-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M9PKM7-1",
            "uniprot_ac": "A0A8M9PKM7",
            "uniprot_id": "A0A8M9PKM7_DANRE",
            "refseq_ac": "XP_021332022",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase TRIM69",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:ch211-114c12.5",
                    "type": "recommended"
                },
                {
                    "name": "si:ch211-114c12.5",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M9PKM7-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M9PX13-1",
            "uniprot_ac": "A0A8M9PX13",
            "uniprot_id": "A0A8M9PX13_DANRE",
            "refseq_ac": "XP_021335987",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase TRIM15",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:dkey-219e21.2",
                    "type": "recommended"
                },
                {
                    "name": "si:dkey-219e21.2",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M9PX13-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9JJ26-1",
            "uniprot_ac": "Q9JJ26",
            "uniprot_id": "MEFV_MOUSE",
            "refseq_ac": "NP_062326",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pyrin",
                    "type": "recommended"
                },
                {
                    "name": "familial mediterranean fever",
                    "type": "synonym"
                },
                {
                    "name": "marenostrin",
                    "type": "synonym"
                },
                {
                    "name": "pyrin isoform 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mefv",
                    "type": "recommended"
                },
                {
                    "name": "FMF",
                    "type": "synonym"
                },
                {
                    "name": "Mefv",
                    "type": "synonym"
                },
                {
                    "name": "TRIM20",
                    "type": "synonym"
                },
                {
                    "name": "pyrin",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9JJ26-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P41245-1",
            "uniprot_ac": "P41245",
            "uniprot_id": "MMP9_MOUSE",
            "refseq_ac": "NP_038627",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Matrix metalloproteinase-9",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.35",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "92kD gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "92kD type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "collagenase type IVB",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp9",
                    "type": "recommended"
                },
                {
                    "name": "B/MMP9",
                    "type": "synonym"
                },
                {
                    "name": "Clg4b",
                    "type": "synonym"
                },
                {
                    "name": "Gel B",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "Mmp9",
                    "type": "synonym"
                },
                {
                    "name": "pro-MMP-9",
                    "type": "synonym"
                }
            ],
            "record_id": "P41245-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33434-1",
            "uniprot_ac": "P33434",
            "uniprot_id": "MMP2_MOUSE",
            "refseq_ac": "NP_032636",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "72 kDa type IV collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72kD gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72kD type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp2",
                    "type": "recommended"
                },
                {
                    "name": "Clg4a",
                    "type": "synonym"
                },
                {
                    "name": "GelA",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Mmp2",
                    "type": "synonym"
                }
            ],
            "record_id": "P33434-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O15553-2",
            "uniprot_ac": "O15553",
            "uniprot_id": "MEFV_HUMAN",
            "refseq_ac": "NP_000234",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pyrin",
                    "type": "recommended"
                },
                {
                    "name": "MEFV innate immuity regulator, pyrin",
                    "type": "synonym"
                },
                {
                    "name": "MEFV, pyrin innate immunity regulator",
                    "type": "synonym"
                },
                {
                    "name": "Marenostrin",
                    "type": "synonym"
                },
                {
                    "name": "Mediterranean fever",
                    "type": "synonym"
                },
                {
                    "name": "marenostrin",
                    "type": "synonym"
                },
                {
                    "name": "pyrin isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "pyrin",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "MEFV",
                    "type": "recommended"
                },
                {
                    "name": "FMF",
                    "type": "synonym"
                },
                {
                    "name": "MEFV",
                    "type": "synonym"
                },
                {
                    "name": "MEF",
                    "type": "synonym"
                },
                {
                    "name": "PAAND",
                    "type": "synonym"
                },
                {
                    "name": "TRIM20",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "608068",
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                    "url": "https://www.omim.org/entry/608068"
                },
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9JJ25-1",
            "uniprot_ac": "Q9JJ25",
            "uniprot_id": "MEFV_RAT",
            "refseq_ac": "NP_113822",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Pyrin",
                    "type": "recommended"
                },
                {
                    "name": "MEFV innate immuity regulator, pyrin",
                    "type": "synonym"
                },
                {
                    "name": "MEFV, pyrin innate immunity regulator",
                    "type": "synonym"
                },
                {
                    "name": "Mediterranean fever",
                    "type": "synonym"
                },
                {
                    "name": "marenostrin",
                    "type": "synonym"
                },
                {
                    "name": "pyrin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mefv",
                    "type": "recommended"
                },
                {
                    "name": "Mefv",
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                },
                {
                    "name": "pyrin",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9JJ25-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P50282-1",
            "uniprot_ac": "P50282",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Matrix metalloproteinase-9",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.35",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "92-kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9 precursor",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mmp9",
                    "type": "recommended"
                },
                {
                    "name": "Mmp9",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P33436-1",
            "uniprot_ac": "P33436",
            "uniprot_id": "MMP2_RAT",
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            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "72 kDa type IV collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 KDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase precursor",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-2",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Mmp2",
                    "type": "recommended"
                },
                {
                    "name": "Mmp2",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08253-1",
            "uniprot_ac": "P08253",
            "uniprot_id": "MMP2_HUMAN",
            "refseq_ac": "NP_001121363",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "72 kDa type IV collagenase",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.24",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "72 kDa type IV collagenase isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase A",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "Matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "TBE-1",
                    "type": "synonym"
                },
                {
                    "name": "collagenase type IV-A",
                    "type": "synonym"
                },
                {
                    "name": "matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-2",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-II",
                    "type": "synonym"
                },
                {
                    "name": "neutrophil gelatinase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MMP2",
                    "type": "recommended"
                },
                {
                    "name": "CLG4A",
                    "type": "synonym"
                },
                {
                    "name": "CLG4",
                    "type": "synonym"
                },
                {
                    "name": "MMP-2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-II",
                    "type": "synonym"
                },
                {
                    "name": "MMP2",
                    "type": "synonym"
                },
                {
                    "name": "MONA",
                    "type": "synonym"
                },
                {
                    "name": "TBE-1",
                    "type": "synonym"
                }
            ],
            "record_id": "P08253-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P14780-1",
            "uniprot_ac": "P14780",
            "uniprot_id": "MMP9_HUMAN",
            "refseq_ac": "NP_004985",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Matrix metalloproteinase-9",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.35",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "macrophage gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "type V collagenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MMP9",
                    "type": "recommended"
                },
                {
                    "name": "CLG4B",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "MANDP2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "MMP9",
                    "type": "synonym"
                }
            ],
            "record_id": "P14780-1",
            "evidence": [
                {
                    "id": "0080746",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080746"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080746"
}