{
    "disease_id": "DOID:0080653",
    "recommended_name": {
        "id": "DOID:0080653",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080653",
        "name": "urolithiasis",
        "description": "A urinary system disease that is characterized by the formation of stony concretions in the bladder or urinary tract."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0080653"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080653",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080653",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M1RIV5-1",
            "uniprot_ac": "A0A8M1RIV5",
            "uniprot_id": "A0A8M1RIV5_DANRE",
            "refseq_ac": "XP_003199339",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin K-dependent gamma-carboxylase",
                    "type": "recommended"
                },
                {
                    "name": "4.1.1.90",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "Peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "Vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ggcx",
                    "type": "recommended"
                },
                {
                    "name": "ggcx",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1RIV5-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06869-1",
            "uniprot_ac": "P06869",
            "uniprot_id": "UROK_MOUSE",
            "refseq_ac": "NP_032899",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Urokinase-type plasminogen activator",
                    "type": "recommended"
                },
                {
                    "name": "3.4.21.73",
                    "type": "synonym"
                },
                {
                    "name": "U-plasminogen activator",
                    "type": "synonym"
                },
                {
                    "name": "uPA",
                    "type": "synonym"
                },
                {
                    "name": "urokinase-type plasminogen activator precursor",
                    "type": "synonym"
                },
                {
                    "name": "urokinase-type plasminogen activator",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Plau",
                    "type": "recommended"
                },
                {
                    "name": "Plau",
                    "type": "synonym"
                },
                {
                    "name": "u-PA",
                    "type": "synonym"
                },
                {
                    "name": "uPA",
                    "type": "synonym"
                }
            ],
            "record_id": "P06869-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9QYC7-1",
            "uniprot_ac": "Q9QYC7",
            "uniprot_id": "VKGC_MOUSE",
            "refseq_ac": "NP_062776",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin K-dependent gamma-carboxylase",
                    "type": "recommended"
                },
                {
                    "name": "4.1.1.90",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "Peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                },
                {
                    "name": "Vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ggcx",
                    "type": "recommended"
                },
                {
                    "name": "Ggcx",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9QYC7-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O88496-1",
            "uniprot_ac": "O88496",
            "uniprot_id": "VKGC_RAT",
            "refseq_ac": "NP_113944",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin K-dependent gamma-carboxylase",
                    "type": "recommended"
                },
                {
                    "name": "4.1.1.90",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "Peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                },
                {
                    "name": "Vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-glutamyl carboxylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ggcx",
                    "type": "recommended"
                },
                {
                    "name": "Ggcx",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                }
            ],
            "record_id": "O88496-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P29598-1",
            "uniprot_ac": "P29598",
            "uniprot_id": "UROK_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Urokinase-type plasminogen activator",
                    "type": "recommended"
                },
                {
                    "name": "3.4.21.73",
                    "type": "synonym"
                },
                {
                    "name": "U-plasminogen activator",
                    "type": "synonym"
                },
                {
                    "name": "uPA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Plau",
                    "type": "recommended"
                }
            ],
            "record_id": "P29598-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W0C4-1",
            "uniprot_ac": "Q9W0C4",
            "uniprot_id": "Q9W0C4_DROME",
            "refseq_ac": "NP_001163323",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "4.1.1.90",
                    "type": "synonym"
                },
                {
                    "name": "CG13927-PB",
                    "type": "synonym"
                },
                {
                    "name": "GC-PB",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "gamma-glutamyl carboxylase, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "gamma-glutamyl-carboxylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "GC",
                    "type": "recommended"
                },
                {
                    "name": "CG13927",
                    "type": "synonym"
                },
                {
                    "name": "DgammaC",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG13927",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG13927",
                    "type": "synonym"
                },
                {
                    "name": "GC",
                    "type": "synonym"
                },
                {
                    "name": "dGC",
                    "type": "synonym"
                },
                {
                    "name": "dgammaC",
                    "type": "synonym"
                },
                {
                    "name": "gammaC",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W0C4-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P19622-1",
            "uniprot_ac": "P19622",
            "uniprot_id": "HME2_HUMAN",
            "refseq_ac": "NP_001418",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Homeobox protein engrailed-2",
                    "type": "recommended"
                },
                {
                    "name": "Homeobox protein en-2",
                    "type": "synonym"
                },
                {
                    "name": "Hu-En-2",
                    "type": "synonym"
                },
                {
                    "name": "engrailed homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "engrailed-2",
                    "type": "synonym"
                },
                {
                    "name": "homeobox protein en-2",
                    "type": "synonym"
                },
                {
                    "name": "homeobox protein engrailed-2",
                    "type": "synonym"
                },
                {
                    "name": "hu-En-2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "EN2",
                    "type": "recommended"
                },
                {
                    "name": "EN2",
                    "type": "synonym"
                }
            ],
            "record_id": "P19622-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P38435-1",
            "uniprot_ac": "P38435",
            "uniprot_id": "VKGC_HUMAN",
            "refseq_ac": "NP_000812",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin K-dependent gamma-carboxylase",
                    "type": "recommended"
                },
                {
                    "name": "4.1.1.90",
                    "type": "synonym"
                },
                {
                    "name": "Gamma-glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "Peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                },
                {
                    "name": "Vitamin K gamma glutamyl carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "peptidyl-glutamate 4-carboxylase",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "vitamin K-dependent gamma-carboxylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "GGCX",
                    "type": "recommended"
                },
                {
                    "name": "GC",
                    "type": "synonym"
                },
                {
                    "name": "GGCX",
                    "type": "synonym"
                },
                {
                    "name": "VKCFD1",
                    "type": "synonym"
                },
                {
                    "name": "VKGC",
                    "type": "synonym"
                }
            ],
            "record_id": "P38435-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P00749-1",
            "uniprot_ac": "P00749",
            "uniprot_id": "UROK_HUMAN",
            "refseq_ac": "NP_001138503",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Urokinase-type plasminogen activator",
                    "type": "recommended"
                },
                {
                    "name": "3.4.21.73",
                    "type": "synonym"
                },
                {
                    "name": "U-plasminogen activator",
                    "type": "synonym"
                },
                {
                    "name": "Urokinase",
                    "type": "synonym"
                },
                {
                    "name": "plasminogen activator, urinary",
                    "type": "synonym"
                },
                {
                    "name": "uPA",
                    "type": "synonym"
                },
                {
                    "name": "urokinase-type plasminogen activator isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "urokinase-type plasminogen activator",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PLAU",
                    "type": "recommended"
                },
                {
                    "name": "ATF",
                    "type": "synonym"
                },
                {
                    "name": "BDPLT5",
                    "type": "synonym"
                },
                {
                    "name": "PLAU",
                    "type": "synonym"
                },
                {
                    "name": "QPD",
                    "type": "synonym"
                },
                {
                    "name": "UPA",
                    "type": "synonym"
                },
                {
                    "name": "URK",
                    "type": "synonym"
                },
                {
                    "name": "u-PA",
                    "type": "synonym"
                }
            ],
            "record_id": "P00749-1",
            "evidence": [
                {
                    "id": "0080653",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080653"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080653"
}