{
    "disease_id": "DOID:0080630",
    "recommended_name": {
        "id": "DOID:0080630",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080630",
        "name": "B-lymphoblastic leukemia/lymphoma",
        "description": "A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow."
    },
    "synonyms": [
        {
            "id": "DOID:0080630",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080630",
            "name": "B lymphoblastic leukemia/lymphoma",
            "description": ""
        },
        {
            "id": "DOID:0080630",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080630",
            "name": "B-ALL",
            "description": ""
        },
        {
            "id": "DOID:0080630",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080630",
            "name": "precursor B lymphoblastic lymphoma/leukemia",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080630"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080630",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080630",
            "categories": []
        }
    ],
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        {
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            "uniprot_ac": "E9QFU2",
            "uniprot_id": "E9QFU2_DANRE",
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                    "glygen_name": "Zebrafish",
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                }
            ],
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                {
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                    "type": "synonym"
                }
            ],
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                    "type": "recommended"
                },
                {
                    "name": "cdkn2a/b",
                    "type": "synonym"
                }
            ],
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                    "id": "0080630",
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                }
            ]
        },
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                    "name": "Danio rerio",
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                }
            ],
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                    "name": "unspecific monooxygenase",
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                    "name": "1.14.14.1",
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                    "name": "cytochrome P450 3A65",
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                {
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                    "type": "synonym"
                }
            ],
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                    "id": "0080630",
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                }
            ]
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                    "name": "Danio rerio",
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                }
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                {
                    "name": "DNA-binding protein Ikaros isoform X1",
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                    "name": "znfn1a1",
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                }
            ],
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                    "name": "Cellular tumor antigen p53",
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                    "name": "Tumor suppressor p53",
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                },
                {
                    "name": "cellular tumor antigen p53 isoform 2",
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                },
                {
                    "name": "cellular tumor antigen p53",
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                {
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                    "name": "etID22686.5",
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                    "name": "fb40d06",
                    "type": "synonym"
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                    "name": "p53",
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                },
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                    "name": "tp53",
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                    "name": "wu:fb40d06",
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                    "id": "0080630",
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                }
            ]
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                }
            ],
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                    "name": "alcohol dehydrogenase (NADP(+))",
                    "type": "recommended"
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                {
                    "name": "1.1.1.2",
                    "type": "synonym"
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                {
                    "name": "S-nitroso-CoA reductase",
                    "type": "synonym"
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                {
                    "name": "uncharacterized protein LOC326033",
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                }
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                {
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                    "name": "zgc:56622",
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                    "name": "fd58h08",
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                {
                    "name": "wu:fd58h08",
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                {
                    "name": "zgc:56622",
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                }
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                {
                    "id": "0080630",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
                }
            ]
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        {
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                    "name": "lipoprotein-associated",
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                    "name": "tissue factor pathway inhibitor a isoform 1 precursor",
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                    "name": "tfpib",
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                    "name": "wu:fb92g01",
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                {
                    "name": "zgc:158592",
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                    "id": "0080630",
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                    "name": "TFb",
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                    "name": "coagulation factor IIIb precursor",
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                    "id": "0080630",
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                    "id": "0080630",
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                    "id": "0080630",
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                    "id": "0080630",
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                    "id": "0080630",
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                {
                    "name": "Cyclin-dependent kinase inhibitor 2A",
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                {
                    "name": "Akr1c3",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
                }
            ]
        },
        {
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "CG33336-PB",
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                    "name": "Dmp53",
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                {
                    "name": "P53, isoform B",
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                {
                    "name": "drosophila p53",
                    "type": "synonym"
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                {
                    "name": "p53, isoform B",
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                {
                    "name": "p53-PB",
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                },
                {
                    "name": "p53-like regulator of apoptosis and cell cycle",
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                {
                    "name": "protein 53",
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                }
            ],
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                {
                    "name": "p53",
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                    "name": "CG10873",
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                },
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                    "name": "CG31325",
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                },
                {
                    "name": "CG33336",
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                },
                {
                    "name": "D-p53",
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                    "name": "DMP53",
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                },
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                    "name": "Dm-P53",
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                    "name": "DmP53",
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                {
                    "name": "Dmel\\CG33336",
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                {
                    "name": "Dmel_CG33336",
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                    "name": "Dmp53",
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                },
                {
                    "name": "Dp53",
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                },
                {
                    "name": "P53",
                    "type": "synonym"
                },
                {
                    "name": "dmP53",
                    "type": "synonym"
                },
                {
                    "name": "dmp53",
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                },
                {
                    "name": "dp53",
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                },
                {
                    "name": "p53",
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                },
                {
                    "name": "prac",
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                }
            ],
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                {
                    "id": "0080630",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
                }
            ]
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            "uniprot_canonical_ac": "P13709-1",
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                }
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                    "name": "Homeotic protein female sterile",
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                    "name": "CG2252-PF",
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                },
                {
                    "name": "Fragile-chorion membrane protein",
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                },
                {
                    "name": "anon-fast-evolving-1G2",
                    "type": "synonym"
                },
                {
                    "name": "female sterile (1) homeotic, isoform F",
                    "type": "synonym"
                },
                {
                    "name": "female sterile (1) homoeotic",
                    "type": "synonym"
                },
                {
                    "name": "female sterile 1 homeotic",
                    "type": "synonym"
                },
                {
                    "name": "female sterile homeotic",
                    "type": "synonym"
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                {
                    "name": "fs(1)h-PF",
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                },
                {
                    "name": "rancor",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "fs(1)h",
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                {
                    "name": "26A",
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                },
                {
                    "name": "Brd4",
                    "type": "synonym"
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                {
                    "name": "CG2252",
                    "type": "synonym"
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                {
                    "name": "Dmel\\CG2252",
                    "type": "synonym"
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                {
                    "name": "Dmel_CG2252",
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                    "name": "FSH-S",
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                {
                    "name": "FSH",
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                {
                    "name": "Fs(1)h-L",
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                {
                    "name": "Fs(1)h/Brd4",
                    "type": "synonym"
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                {
                    "name": "Fs(1)hL",
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                },
                {
                    "name": "Fs(1)hS",
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                {
                    "name": "Fs(1)h",
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                {
                    "name": "N72",
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                {
                    "name": "ORE-1",
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                {
                    "name": "anon-EST:Liang-1.81",
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                {
                    "name": "anon-EST:fe1G2",
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                    "name": "fs(1)1456",
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                    "name": "fs(1)26/26A",
                    "type": "synonym"
                },
                {
                    "name": "fs(1)M16",
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                {
                    "name": "fs(1)R10.4",
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                    "name": "fs(1)h",
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                    "name": "fs[1]h",
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                {
                    "name": "fsh",
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                {
                    "name": "fst(1)h",
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                {
                    "name": "l(1)7Da",
                    "type": "synonym"
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                {
                    "name": "l(1)G0093",
                    "type": "synonym"
                },
                {
                    "name": "l(1)G0495",
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                {
                    "name": "rnc",
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                }
            ],
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                    "id": "0080630",
                    "database": "AGR",
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                }
            ]
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                }
            ],
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                    "name": "CG13597-PA",
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                {
                    "name": "Testis-specifically expressed bromodomain containing protein-1, isoform A",
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                },
                {
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                    "type": "synonym"
                },
                {
                    "name": "tbrd-1-PA",
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                },
                {
                    "name": "testis-specifically expressed bromodomain containing protein-1, isoform A",
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            ],
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                {
                    "name": "tbrd-1",
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                    "name": "CG13597",
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                {
                    "name": "Dmel\\CG13597",
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                {
                    "name": "Dmel_CG13597",
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                {
                    "name": "tBRD-1",
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                {
                    "name": "tBrd-1",
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                },
                {
                    "name": "tbrd-1",
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                }
            ],
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                    "id": "0080630",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P00522-1",
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                }
            ],
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                    "name": "Tyrosine-protein kinase Abl",
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                {
                    "name": "Abl oncogene",
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                },
                {
                    "name": "Abl tyrosine kinase, isoform J",
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                    "name": "Abl-PJ",
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                {
                    "name": "CG4032-PJ",
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                {
                    "name": "D-abelson",
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                {
                    "name": "D-ash",
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                {
                    "name": "Protein abelson",
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                {
                    "name": "abelson kinase",
                    "type": "synonym"
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                {
                    "name": "abelson tyrosine kinase",
                    "type": "synonym"
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                {
                    "name": "abl kinase",
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                    "name": "Abl",
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                {
                    "name": "4674",
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                    "name": "ABL-1",
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                {
                    "name": "ABL",
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                {
                    "name": "Abl1",
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                {
                    "name": "AblK",
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                {
                    "name": "Ableson",
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                {
                    "name": "Abl",
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                },
                {
                    "name": "Am ABL",
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                    "name": "C-abl",
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                    "name": "CG4032",
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                    "name": "D-Abl",
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                {
                    "name": "D-abl",
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                {
                    "name": "D-ash",
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                {
                    "name": "DAbl",
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                {
                    "name": "DROTKABL3",
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                {
                    "name": "Dabl",
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                {
                    "name": "Dash",
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                    "name": "Ddash/abl",
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                    "name": "Dmel\\CG4032",
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                {
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                    "name": "abl",
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                    "name": "c-abl",
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                    "name": "cAbl",
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                {
                    "name": "dAbl",
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                {
                    "name": "l(3)04674",
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                },
                {
                    "name": "l(3)73Ba",
                    "type": "synonym"
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                {
                    "name": "l(3)c-abl",
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                }
            ],
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                    "id": "0080630",
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                }
            ],
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                {
                    "name": "CG10863-PA",
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                {
                    "name": "uncharacterized protein",
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            ],
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                    "name": "Ar3",
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                    "name": "AKR2E3",
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                },
                {
                    "name": "Akr2E3",
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                {
                    "name": "BcDNA:GH10614",
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                    "id": "0080630",
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            ]
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                {
                    "name": "CG8222-PJ",
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                {
                    "name": "PDGF receptor",
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                },
                {
                    "name": "PDGF- and VEGF receptor related",
                    "type": "synonym"
                },
                {
                    "name": "PDGF- and VEGF- receptor related",
                    "type": "synonym"
                },
                {
                    "name": "PDGF- and VEGF-Receptor related",
                    "type": "synonym"
                },
                {
                    "name": "PDGF- and VEGF-receptor related, isoform J",
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                },
                {
                    "name": "PDGF- and VEGF-related receptor",
                    "type": "synonym"
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                {
                    "name": "PDGF/VEGF receptor",
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                    "name": "PVF receptor",
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                {
                    "name": "Pvr-PJ",
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                {
                    "name": "VEGF receptor",
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                },
                {
                    "name": "stasis",
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                {
                    "name": "vascular endothelial growth factor receptor-1 like",
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                {
                    "name": "vascular endothelial growth factor receptor",
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                    "name": "CG8222",
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                {
                    "name": "CT24332",
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                {
                    "name": "Dmel\\CG8222",
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                {
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                    "name": "PvR",
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                {
                    "name": "VEGFR-A",
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                    "name": "VEGFR",
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                {
                    "name": "VGR1",
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                {
                    "name": "Vegfr-b",
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                {
                    "name": "Vegfr-c",
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                {
                    "name": "Vegfr",
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                {
                    "name": "Vegf",
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                {
                    "name": "Vgr1",
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                {
                    "name": "pvr",
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                {
                    "name": "stai",
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                {
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                    "id": "0080630",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
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                }
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                {
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                {
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                {
                    "name": "Transglutaminase-A",
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                },
                {
                    "name": "transglutaminase, isoform A",
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                    "name": "transglutaminase",
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                    "name": "CG7356",
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                {
                    "name": "DmTG",
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                {
                    "name": "Dmel\\CG7356",
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                {
                    "name": "Dmel_CG7356",
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                {
                    "name": "TG",
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                {
                    "name": "Tg",
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                {
                    "name": "dTG-alpha",
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                {
                    "name": "dTG",
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                {
                    "name": "tg",
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            ],
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                    "id": "0080630",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
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            ]
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        {
            "uniprot_canonical_ac": "Q24151-1",
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            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Signal transducer and transcription activator",
                    "type": "recommended"
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                {
                    "name": "CG4257-PG",
                    "type": "synonym"
                },
                {
                    "name": "Protein marelle",
                    "type": "synonym"
                },
                {
                    "name": "Signal-transducer and activator of transcription protein at 92E, isoform G",
                    "type": "synonym"
                },
                {
                    "name": "Signal-transducer and activator of transcription protein",
                    "type": "synonym"
                },
                {
                    "name": "Stat92E-PG",
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                    "name": "d-STAT",
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                {
                    "name": "marelle",
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                    "name": "signal transducer and activator of transcription",
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                {
                    "name": "signal transducers and activator of transcription",
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                    "name": "D-STAT",
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                    "name": "Dstat92E",
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                {
                    "name": "Dstat",
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                    "name": "Dst",
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                    "name": "MARE",
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                    "name": "SD-stat",
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                    "name": "STAT 92E",
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                    "name": "STAT92E",
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                    "name": "STAT92e",
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                    "name": "STAT",
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                    "name": "Sta92E",
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                    "name": "Stat1alpha-like",
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                    "name": "Stat92E",
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                {
                    "name": "Stat92e",
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                    "name": "Stat92",
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                    "name": "marelle",
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                    "name": "mrL",
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                    "name": "stat[92E]",
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                    "name": "dmMYB",
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                    "name": "dmyb",
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                }
            ]
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                    "name": "Extrinsic pathway inhibitor",
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                {
                    "name": "Lipoprotein-associated coagulation inhibitor",
                    "type": "synonym"
                },
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                    "name": "TFPI",
                    "type": "synonym"
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                    "name": "anti-convertin",
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                    "type": "synonym"
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                {
                    "name": "tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)",
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                }
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                    "name": "LACI",
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                    "name": "TFI",
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                },
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                    "type": "synonym"
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                    "name": "TFPI",
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                    "name": "coagulation factor III (thromboplastin, tissue factor)",
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                    "name": "F3",
                    "type": "synonym"
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                    "name": "TFA",
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                }
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                    "id": "0080630",
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                }
            ]
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                    "name": "Homo sapiens",
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                {
                    "name": "1.1.1.188",
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                {
                    "name": "1.1.1.210",
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                    "name": "1.1.1.357",
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                {
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                {
                    "name": "3-alpha hydroxysteroid dehydrogenase, type II",
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                {
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                    "type": "synonym"
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                {
                    "name": "3-alpha-HSD type II, brain",
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                {
                    "name": "3-alpha-hydroxysteroid dehydrogenase type 2",
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                {
                    "name": "Chlordecone reductase homolog HAKRb",
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                    "name": "DD-3",
                    "type": "synonym"
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                {
                    "name": "DD3",
                    "type": "synonym"
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                {
                    "name": "Dihydrodiol dehydrogenase 3",
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                },
                {
                    "name": "Dihydrodiol dehydrogenase type I",
                    "type": "synonym"
                },
                {
                    "name": "HA1753",
                    "type": "synonym"
                },
                {
                    "name": "PGFS",
                    "type": "synonym"
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                {
                    "name": "Prostaglandin F synthase",
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                {
                    "name": "Testosterone 17-beta-dehydrogenase 5",
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                },
                {
                    "name": "aldo-keto reductase family 1 member C3 isoform 2",
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                },
                {
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                },
                {
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                    "type": "synonym"
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                {
                    "name": "dihydrodiol dehydrogenase X",
                    "type": "synonym"
                },
                {
                    "name": "indanol dehydrogenase",
                    "type": "synonym"
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                {
                    "name": "prostaglandin F synthase",
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                {
                    "name": "testosterone 17-beta-dehydrogenase 5",
                    "type": "synonym"
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                {
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                    "name": "type IIb 3-alpha hydroxysteroid dehydrogenase",
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                    "name": "AKR1C3",
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                {
                    "name": "DD3",
                    "type": "synonym"
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                    "name": "DDH1",
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                    "name": "HAKRe",
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                {
                    "name": "KIAA0119",
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                {
                    "name": "hluPGFS",
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                    "id": "0080630",
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                {
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                {
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                {
                    "name": "TNF-related death ligand 1",
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                {
                    "name": "TRDL-1",
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                {
                    "name": "a proliferation-inducing ligand",
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                {
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                {
                    "name": "tumor necrosis factor ligand 7B",
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                {
                    "name": "tumor necrosis factor ligand superfamily member 13 isoform zeta",
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                {
                    "name": "tumor necrosis factor superfamily member 13",
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                {
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                {
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                {
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                {
                    "name": "TNLG7B",
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                {
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                {
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                    "name": "FSH",
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                {
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                {
                    "name": "KIAA9001",
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                {
                    "name": "NAT",
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                {
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                {
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                {
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                {
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                {
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                {
                    "name": "BCR::ABL1 fusion protein",
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                {
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                {
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                {
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                {
                    "name": "tyrosine-protein kinase ABL1 isoform a",
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                {
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                {
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                {
                    "name": "cellular tumor antigen p53",
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                    "name": "IKZF1",
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                {
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                {
                    "name": "LyF-1",
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                {
                    "name": "PPP1R92",
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                {
                    "name": "PRO0758",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P42771-1",
            "uniprot_ac": "P42771",
            "uniprot_id": "CDN2A_HUMAN",
            "refseq_ac": "NP_000068",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cyclin-dependent kinase inhibitor 2A",
                    "type": "recommended"
                },
                {
                    "name": "CDK4 inhibitor p16-INK4",
                    "type": "synonym"
                },
                {
                    "name": "CDK4I",
                    "type": "synonym"
                },
                {
                    "name": "CDKN2A/ARF Intron 2 lncRNA",
                    "type": "synonym"
                },
                {
                    "name": "Cyclin-dependent kinase 4 inhibitor A",
                    "type": "synonym"
                },
                {
                    "name": "MTS-1",
                    "type": "synonym"
                },
                {
                    "name": "Multiple tumor suppressor 1",
                    "type": "synonym"
                },
                {
                    "name": "alternative reading frame",
                    "type": "synonym"
                },
                {
                    "name": "cell cycle negative regulator beta",
                    "type": "synonym"
                },
                {
                    "name": "cyclin-dependent kinase 4 inhibitor A",
                    "type": "synonym"
                },
                {
                    "name": "cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)",
                    "type": "synonym"
                },
                {
                    "name": "cyclin-dependent kinase inhibitor 2A isoform p16INK4a",
                    "type": "synonym"
                },
                {
                    "name": "inhibitor of cdk4 A",
                    "type": "synonym"
                },
                {
                    "name": "multiple tumor suppressor 1",
                    "type": "synonym"
                },
                {
                    "name": "multiple tumour suppressor 1",
                    "type": "synonym"
                },
                {
                    "name": "p16-INK4a",
                    "type": "synonym"
                },
                {
                    "name": "p16-INK4",
                    "type": "synonym"
                },
                {
                    "name": "p16INK4A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CDKN2A",
                    "type": "recommended"
                },
                {
                    "name": "ARF",
                    "type": "synonym"
                },
                {
                    "name": "CAI2",
                    "type": "synonym"
                },
                {
                    "name": "CDK4I",
                    "type": "synonym"
                },
                {
                    "name": "CDKN2A",
                    "type": "synonym"
                },
                {
                    "name": "CDKN2",
                    "type": "synonym"
                },
                {
                    "name": "CMM2",
                    "type": "synonym"
                },
                {
                    "name": "INK4A",
                    "type": "synonym"
                },
                {
                    "name": "INK4",
                    "type": "synonym"
                },
                {
                    "name": "MLM",
                    "type": "synonym"
                },
                {
                    "name": "MTS-1",
                    "type": "synonym"
                },
                {
                    "name": "MTS1",
                    "type": "synonym"
                },
                {
                    "name": "P14ARF",
                    "type": "synonym"
                },
                {
                    "name": "P14",
                    "type": "synonym"
                },
                {
                    "name": "P16-INK4A",
                    "type": "synonym"
                },
                {
                    "name": "P16INK4A",
                    "type": "synonym"
                },
                {
                    "name": "P16INK4",
                    "type": "synonym"
                },
                {
                    "name": "P16",
                    "type": "synonym"
                },
                {
                    "name": "P19ARF",
                    "type": "synonym"
                },
                {
                    "name": "P19",
                    "type": "synonym"
                },
                {
                    "name": "TP16",
                    "type": "synonym"
                }
            ],
            "record_id": "P42771-1",
            "evidence": [
                {
                    "id": "0080630",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20815-1",
            "uniprot_ac": "P20815",
            "uniprot_id": "CP3A5_HUMAN",
            "refseq_ac": "NP_000768",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytochrome P450 3A5",
                    "type": "recommended"
                },
                {
                    "name": "1.14.14.1",
                    "type": "synonym"
                },
                {
                    "name": "CYPIIIA5",
                    "type": "synonym"
                },
                {
                    "name": "Cytochrome P450-PCN3",
                    "type": "synonym"
                },
                {
                    "name": "aryl hydrocarbon hydroxylase",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450 3A5 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450 3A5",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450 HLp2",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, family 3, subfamily A, polypeptide 5",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450-PCN3",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein-linked monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "microsomal monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "xenobiotic monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CYP3A5",
                    "type": "recommended"
                },
                {
                    "name": "CP35",
                    "type": "synonym"
                },
                {
                    "name": "CYP3A5",
                    "type": "synonym"
                },
                {
                    "name": "CYPIIIA5",
                    "type": "synonym"
                },
                {
                    "name": "P450PCN3",
                    "type": "synonym"
                },
                {
                    "name": "PCN3",
                    "type": "synonym"
                }
            ],
            "record_id": "P20815-1",
            "evidence": [
                {
                    "id": "0080630",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080630"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080630"
}