{
    "disease_id": "DOID:0070662",
    "recommended_name": {
        "id": "DOID:0070662",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070662",
        "name": "subcutaneous panniculitis-like T-cell lymphoma",
        "description": "A primary cutaneous T-cell non-Hodgkin lymphoma characterized by infiltration of subcutaneous tissue by neoplastic alpha-beta cytotoxic T cells mimicking panniculitis. Homozygous or compound heterozygous mutation in the HAVCR2 gene may contribute to development of this disease, with some evidence of incomplete penetrance."
    },
    "synonyms": [
        {
            "id": "DOID:0070662",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070662",
            "name": "SPTCL",
            "description": ""
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "subcutaneous panniculitis-like T-cell lymphoma",
            "description": "Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic cutaneous lymphoma that has been recognized as a distinct subset of peripheral T-cell lymphomas originating and presenting primarily in the subcutaneous fat tissue."
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "SPTCL",
            "description": ""
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "subcutaneous panniculitic T-cell lymphoma",
            "description": ""
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "subcutaneous panniculitis-like T-cell lymphoma",
            "description": ""
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "subcutaneous panniculitis-like T-cell lymphoma (Alpha/Beta type)",
            "description": ""
        },
        {
            "id": "MONDO:0019475",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "name": "subcutaneous panniculitis-like T-cell lymphoma, Alpha/Beta type",
            "description": ""
        },
        {
            "id": "MIM:618398",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/618398",
            "name": "T-cell lymphoma, subcutaneous panniculitis-like",
            "description": "T-cell lymphoma, subcutaneous panniculitis-like"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070662"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070662",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070662",
            "categories": []
        },
        {
            "id": "MONDO:0019475",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0019475",
            "categories": []
        },
        {
            "id": "MIM:618398",
            "database": "MIM",
            "url": "https://www.omim.org/entry/618398",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "E7FEV9-1",
            "uniprot_ac": "E7FEV9",
            "uniprot_id": "E7FEV9_DANRE",
            "refseq_ac": "XP_003200921",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Hepatitis A virus cellular receptor 1 homolog isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 1 homolog isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "havcr2",
                    "type": "recommended"
                },
                {
                    "name": "havcr2",
                    "type": "synonym"
                }
            ],
            "record_id": "E7FEV9-1",
            "evidence": [
                {
                    "id": "0070662",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070662"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8VIM0-1",
            "uniprot_ac": "Q8VIM0",
            "uniprot_id": "HAVR2_MOUSE",
            "refseq_ac": "NP_599011",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Hepatitis A virus cellular receptor 2 homolog",
                    "type": "recommended"
                },
                {
                    "name": "HAVcr-2",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin and mucin domain containing 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin and mucin domain-containing protein 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin mucin receptor 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell membrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "TIM-3",
                    "type": "synonym"
                },
                {
                    "name": "TIMD-3",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 2 homolog precursor",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 2 homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Havcr2",
                    "type": "recommended"
                },
                {
                    "name": "Havcr2",
                    "type": "synonym"
                },
                {
                    "name": "TIM-3",
                    "type": "synonym"
                },
                {
                    "name": "Tim3",
                    "type": "synonym"
                },
                {
                    "name": "Timd3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8VIM0-1",
            "evidence": [
                {
                    "id": "0070662",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070662"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8TDQ0-1",
            "uniprot_ac": "Q8TDQ0",
            "uniprot_id": "HAVR2_HUMAN",
            "refseq_ac": "NP_116171",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Hepatitis A virus cellular receptor 2",
                    "type": "recommended"
                },
                {
                    "name": "HAVcr-2",
                    "type": "synonym"
                },
                {
                    "name": "T cell immunoglobulin mucin 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin and mucin domain 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin and mucin domain-containing protein 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin mucin family member 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin mucin receptor 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell membrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "TIM-3",
                    "type": "synonym"
                },
                {
                    "name": "TIMD-3",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 2 precursor",
                    "type": "synonym"
                },
                {
                    "name": "kidney injury molecule-3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HAVCR2",
                    "type": "recommended"
                },
                {
                    "name": "CD366",
                    "type": "synonym"
                },
                {
                    "name": "HAVCR2",
                    "type": "synonym"
                },
                {
                    "name": "HAVcr-2",
                    "type": "synonym"
                },
                {
                    "name": "KIM-3",
                    "type": "synonym"
                },
                {
                    "name": "SPTCL",
                    "type": "synonym"
                },
                {
                    "name": "TIM3",
                    "type": "synonym"
                },
                {
                    "name": "TIMD-3",
                    "type": "synonym"
                },
                {
                    "name": "TIMD3",
                    "type": "synonym"
                },
                {
                    "name": "Tim-3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8TDQ0-1",
            "evidence": [
                {
                    "id": "618398",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618398"
                },
                {
                    "id": "0070662",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070662"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P0C0K5-1",
            "uniprot_ac": "P0C0K5",
            "uniprot_id": "HAVR2_RAT",
            "refseq_ac": "NP_001094232",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Hepatitis A virus cellular receptor 2 homolog",
                    "type": "recommended"
                },
                {
                    "name": "HAVcr-2",
                    "type": "synonym"
                },
                {
                    "name": "T cell immunoglobulin mucin-3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin and mucin domain-containing protein 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell immunoglobulin mucin receptor 3",
                    "type": "synonym"
                },
                {
                    "name": "T-cell membrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "TIM-3",
                    "type": "synonym"
                },
                {
                    "name": "TIMD-3",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 2 homolog precursor",
                    "type": "synonym"
                },
                {
                    "name": "hepatitis A virus cellular receptor 2 homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Havcr2",
                    "type": "recommended"
                },
                {
                    "name": "Havcr2",
                    "type": "synonym"
                },
                {
                    "name": "Tim3",
                    "type": "synonym"
                },
                {
                    "name": "Timd3",
                    "type": "synonym"
                },
                {
                    "name": "tim3",
                    "type": "synonym"
                }
            ],
            "record_id": "P0C0K5-1",
            "evidence": [
                {
                    "id": "0070662",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070662"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070662"
}