{
    "disease_id": "DOID:0070413",
    "recommended_name": {
        "id": "DOID:0070413",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070413",
        "name": "autosomal recessive spinocerebellar ataxia 32",
        "description": "An autosomal recessive cerebellar ataxia characterized by onset of gait ataxia in the second or third decade of life that has_material_basis_in homozygous or compound heterozygous mutation in the PRDX3 gene on chromosome 10q26."
    },
    "synonyms": [
        {
            "id": "DOID:0070413",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070413",
            "name": "SCAR32",
            "description": ""
        },
        {
            "id": "MONDO:0859245",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0859245",
            "name": "spinocerebellar ataxia, autosomal recessive 32",
            "description": ""
        },
        {
            "id": "MIM:619862",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/619862",
            "name": "Spinocerebellar ataxia, autosomal recessive, 32",
            "description": "Spinocerebellar ataxia, autosomal recessive, 32"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070413"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070413",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070413",
            "categories": []
        },
        {
            "id": "MONDO:0859245",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0859245",
            "categories": []
        },
        {
            "id": "MIM:619862",
            "database": "MIM",
            "url": "https://www.omim.org/entry/619862",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P20108-1",
            "uniprot_ac": "P20108",
            "uniprot_id": "PRDX3_MOUSE",
            "refseq_ac": "NP_031478",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "AOP-1",
                    "type": "synonym"
                },
                {
                    "name": "Antioxidant protein 1",
                    "type": "synonym"
                },
                {
                    "name": "PRX III",
                    "type": "synonym"
                },
                {
                    "name": "Perioredoxin-3",
                    "type": "synonym"
                },
                {
                    "name": "Protein MER5",
                    "type": "synonym"
                },
                {
                    "name": "Prx III",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                },
                {
                    "name": "anti-oxidant protein 1",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial Trx dependent peroxide reductase",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial thioredoxin dependent peroxide reductase",
                    "type": "synonym"
                },
                {
                    "name": "perioredoxin-3",
                    "type": "synonym"
                },
                {
                    "name": "peroxiredoxin III",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial precursor",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Prdx3",
                    "type": "recommended"
                },
                {
                    "name": "Aop1",
                    "type": "synonym"
                },
                {
                    "name": "D0Tohi1",
                    "type": "synonym"
                },
                {
                    "name": "Ef2l",
                    "type": "synonym"
                },
                {
                    "name": "Mer5",
                    "type": "synonym"
                },
                {
                    "name": "Prdx3",
                    "type": "synonym"
                },
                {
                    "name": "Prx3",
                    "type": "synonym"
                },
                {
                    "name": "SP22",
                    "type": "synonym"
                },
                {
                    "name": "TDXM",
                    "type": "synonym"
                }
            ],
            "record_id": "P20108-1",
            "evidence": [
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P30048-1",
            "uniprot_ac": "P30048",
            "uniprot_id": "PRDX3_HUMAN",
            "refseq_ac": "NP_001289201",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "AOP-1",
                    "type": "synonym"
                },
                {
                    "name": "Antioxidant protein 1",
                    "type": "synonym"
                },
                {
                    "name": "HBC189",
                    "type": "synonym"
                },
                {
                    "name": "Peroxiredoxin III",
                    "type": "synonym"
                },
                {
                    "name": "Peroxiredoxin-3",
                    "type": "synonym"
                },
                {
                    "name": "Protein MER5 homolog",
                    "type": "synonym"
                },
                {
                    "name": "Prx-III",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                },
                {
                    "name": "antioxidant protein 1",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "peroxiredoxin III",
                    "type": "synonym"
                },
                {
                    "name": "protein MER5 homolog",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PRDX3",
                    "type": "recommended"
                },
                {
                    "name": "AOP-1",
                    "type": "synonym"
                },
                {
                    "name": "AOP1",
                    "type": "synonym"
                },
                {
                    "name": "HBC189",
                    "type": "synonym"
                },
                {
                    "name": "MER5",
                    "type": "synonym"
                },
                {
                    "name": "PPPCD",
                    "type": "synonym"
                },
                {
                    "name": "PRDX3",
                    "type": "synonym"
                },
                {
                    "name": "PRO1748",
                    "type": "synonym"
                },
                {
                    "name": "SCAR32",
                    "type": "synonym"
                },
                {
                    "name": "SP-22",
                    "type": "synonym"
                },
                {
                    "name": "prx-III",
                    "type": "synonym"
                }
            ],
            "record_id": "P30048-1",
            "evidence": [
                {
                    "id": "619862",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/619862"
                },
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q04120-1",
            "uniprot_ac": "Q04120",
            "uniprot_id": "TSA2_YEAST",
            "refseq_ac": "NP_010741",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Peroxiredoxin TSA2",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "Cytoplasmic thiol peroxidase 2",
                    "type": "synonym"
                },
                {
                    "name": "Prx",
                    "type": "synonym"
                },
                {
                    "name": "TPx type Ib",
                    "type": "synonym"
                },
                {
                    "name": "Thiol-specific antioxidant protein 2",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin peroxidase type Ib",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxiredoxin TSA2",
                    "type": "synonym"
                },
                {
                    "name": "cTPx 2",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin peroxidase TSA2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TSA2",
                    "type": "recommended"
                },
                {
                    "name": "D9461.38",
                    "type": "synonym"
                },
                {
                    "name": "TSA2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q04120-1",
            "evidence": [
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P34760-1",
            "uniprot_ac": "P34760",
            "uniprot_id": "TSA1_YEAST",
            "refseq_ac": "NP_013684",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Peroxiredoxin TSA1",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "Cytoplasmic thiol peroxidase 1",
                    "type": "synonym"
                },
                {
                    "name": "PRP",
                    "type": "synonym"
                },
                {
                    "name": "Protector protein",
                    "type": "synonym"
                },
                {
                    "name": "Prx",
                    "type": "synonym"
                },
                {
                    "name": "TPx type Ia",
                    "type": "synonym"
                },
                {
                    "name": "Thiol-specific antioxidant protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin peroxidase type Ia",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxide reductase",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxiredoxin TSA1",
                    "type": "synonym"
                },
                {
                    "name": "cTPx 1",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin peroxidase TSA1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TSA1",
                    "type": "recommended"
                },
                {
                    "name": "TPX1",
                    "type": "synonym"
                },
                {
                    "name": "TSA1",
                    "type": "synonym"
                },
                {
                    "name": "TSA",
                    "type": "synonym"
                },
                {
                    "name": "ZRG14",
                    "type": "synonym"
                }
            ],
            "record_id": "P34760-1",
            "evidence": [
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Z0V6-1",
            "uniprot_ac": "Q9Z0V6",
            "uniprot_id": "PRDX3_RAT",
            "refseq_ac": "NP_071985",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "PRX-3",
                    "type": "synonym"
                },
                {
                    "name": "PRx III",
                    "type": "synonym"
                },
                {
                    "name": "Peroxiredoxin-3",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial precursor",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-dependent peroxiredoxin 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Prdx3",
                    "type": "recommended"
                },
                {
                    "name": "Prdx3",
                    "type": "synonym"
                },
                {
                    "name": "Prx3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Z0V6-1",
            "evidence": [
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VEJ0-1",
            "uniprot_ac": "Q9VEJ0",
            "uniprot_id": "PRDX3_DROME",
            "refseq_ac": "NP_524387",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thioredoxin-dependent peroxide reductase, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.11.1.24",
                    "type": "synonym"
                },
                {
                    "name": "CG5826-PA",
                    "type": "synonym"
                },
                {
                    "name": "Peroxiredoxin 3",
                    "type": "synonym"
                },
                {
                    "name": "Prx3-PA",
                    "type": "synonym"
                },
                {
                    "name": "Thioredoxinperoxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial peroxiredoxin",
                    "type": "synonym"
                },
                {
                    "name": "peroxiredoxin 3",
                    "type": "synonym"
                },
                {
                    "name": "peroxiredoxin 5037",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin peroxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "thioredoxin-peroxidase-3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Prx3",
                    "type": "recommended"
                },
                {
                    "name": "CG5826",
                    "type": "synonym"
                },
                {
                    "name": "DPx-5037",
                    "type": "synonym"
                },
                {
                    "name": "DPx5037",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5826",
                    "type": "synonym"
                },
                {
                    "name": "Prx3",
                    "type": "synonym"
                },
                {
                    "name": "Prx5037",
                    "type": "synonym"
                },
                {
                    "name": "dPRDX3",
                    "type": "synonym"
                },
                {
                    "name": "dPrx3",
                    "type": "synonym"
                },
                {
                    "name": "dprx3",
                    "type": "synonym"
                },
                {
                    "name": "mTPx",
                    "type": "synonym"
                },
                {
                    "name": "mtTPx",
                    "type": "synonym"
                },
                {
                    "name": "peroxiredoxin 5037",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VEJ0-1",
            "evidence": [
                {
                    "id": "0070413",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070413"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070413"
}