{
    "disease_id": "DOID:0050634",
    "recommended_name": {
        "id": "DOID:0050634",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050634",
        "name": "alopecia universalis",
        "description": "An alopecia characterized by the complete loss of hair on the scalp and body."
    },
    "synonyms": [
        {
            "id": "DOID:0050634",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050634",
            "name": "ALOPECIA UNIVERSALIS CONGENITA",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "alopecia universalis congenita",
            "description": "The most severe form of alopecia areata, an inflammatory disease of the hair follicle, which is characterized by a complete loss of hair of the scalp and all the hair-bearing areas of the body."
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "alopecia universalis congenita",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "atrichia, generalised",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "atrichia, generalized",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "ALUNC",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "AU",
            "description": ""
        },
        {
            "id": "MONDO:0008757",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "name": "alopecia areata universalis",
            "description": ""
        },
        {
            "id": "MIM:203655",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/203655",
            "name": "Alopecia universalis congenita",
            "description": "Alopecia universalis congenita"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050634"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050634",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050634",
            "categories": []
        },
        {
            "id": "MONDO:0008757",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008757",
            "categories": []
        },
        {
            "id": "MIM:203655",
            "database": "MIM",
            "url": "https://www.omim.org/entry/203655",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q61645-1",
            "uniprot_ac": "Q61645",
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            "refseq_ac": "NP_068677",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Lysine-specific demethylase hairless",
                    "type": "recommended"
                },
                {
                    "name": "1.14.11.65",
                    "type": "synonym"
                },
                {
                    "name": "[histone H3]-dimethyl-L-lysine(9) demethylase hairless",
                    "type": "synonym"
                },
                {
                    "name": "lysine demethylase and nuclear receptor corepressor",
                    "type": "synonym"
                },
                {
                    "name": "lysine-specific demethylase hairless",
                    "type": "synonym"
                },
                {
                    "name": "protein hairless",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Hr",
                    "type": "recommended"
                },
                {
                    "name": "ALUNC",
                    "type": "synonym"
                },
                {
                    "name": "Hr",
                    "type": "synonym"
                },
                {
                    "name": "bldy",
                    "type": "synonym"
                },
                {
                    "name": "rh-bmh",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050634",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050634"
                }
            ]
        },
        {
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            "uniprot_ac": "P07750",
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            "refseq_ac": "NP_067258",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
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                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-4",
                    "type": "recommended"
                },
                {
                    "name": "B-cell IgG differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "B-cell growth factor 1",
                    "type": "synonym"
                },
                {
                    "name": "B-cell stimulatory factor 1",
                    "type": "synonym"
                },
                {
                    "name": "BSF-1",
                    "type": "synonym"
                },
                {
                    "name": "IGG1 induction factor",
                    "type": "synonym"
                },
                {
                    "name": "IL-4",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte stimulatory factor 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 precursor",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte stimulatory factor 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Il4",
                    "type": "recommended"
                },
                {
                    "name": "BSF-1",
                    "type": "synonym"
                },
                {
                    "name": "Il-4",
                    "type": "synonym"
                },
                {
                    "name": "Il4",
                    "type": "synonym"
                }
            ],
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                    "id": "0050634",
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                }
            ]
        },
        {
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            "uniprot_ac": "O43593",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Lysine-specific demethylase hairless",
                    "type": "recommended"
                },
                {
                    "name": "1.14.11.65",
                    "type": "synonym"
                },
                {
                    "name": "[histone H3]-dimethyl-L-lysine(9) demethylase hairless",
                    "type": "synonym"
                },
                {
                    "name": "hair growth associated",
                    "type": "synonym"
                },
                {
                    "name": "hairless homolog",
                    "type": "synonym"
                },
                {
                    "name": "lysine demethylase 3D",
                    "type": "synonym"
                },
                {
                    "name": "lysine-specific demethylase hairless isoform a",
                    "type": "synonym"
                },
                {
                    "name": "lysine-specific demethylase hairless",
                    "type": "synonym"
                },
                {
                    "name": "protein hairless",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HR",
                    "type": "recommended"
                },
                {
                    "name": "ALUNC",
                    "type": "synonym"
                },
                {
                    "name": "AU",
                    "type": "synonym"
                },
                {
                    "name": "HR",
                    "type": "synonym"
                },
                {
                    "name": "HSA277165",
                    "type": "synonym"
                },
                {
                    "name": "HYPT4",
                    "type": "synonym"
                },
                {
                    "name": "KDM3D",
                    "type": "synonym"
                },
                {
                    "name": "MUHH1",
                    "type": "synonym"
                },
                {
                    "name": "MUHH",
                    "type": "synonym"
                }
            ],
            "record_id": "O43593-1",
            "evidence": [
                {
                    "id": "203655",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/203655"
                },
                {
                    "id": "0050634",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050634"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P97609-1",
            "uniprot_ac": "P97609",
            "uniprot_id": "HAIR_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Lysine-specific demethylase hairless",
                    "type": "recommended"
                },
                {
                    "name": "1.14.11.65",
                    "type": "synonym"
                },
                {
                    "name": "[histone H3]-dimethyl-L-lysine(9) demethylase hairless",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Hr",
                    "type": "recommended"
                }
            ],
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            "evidence": [
                {
                    "id": "0050634",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050634"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20096-1",
            "uniprot_ac": "P20096",
            "uniprot_id": "IL4_RAT",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Interleukin-4",
                    "type": "recommended"
                },
                {
                    "name": "B-cell IGG differentiation factor",
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                {
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                    "type": "synonym"
                },
                {
                    "name": "B-cell stimulatory factor 1",
                    "type": "synonym"
                },
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                    "name": "BSF-1",
                    "type": "synonym"
                },
                {
                    "name": "IL-4",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte stimulatory factor 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 precursor",
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                {
                    "name": "lymphocyte stimulatory factor 1",
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                }
            ],
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                    "name": "Il4",
                    "type": "recommended"
                },
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                    "name": "Il-4",
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                },
                {
                    "name": "Il4e12",
                    "type": "synonym"
                },
                {
                    "name": "Il4",
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                    "id": "0050634",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VHC5-1",
            "uniprot_ac": "Q9VHC5",
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            "refseq_ac": "NP_001287255",
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            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Lysine-specific demethylase 3",
                    "type": "recommended"
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                    "name": "1.14.11.65",
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                },
                {
                    "name": "CG8165-PB",
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                {
                    "name": "JmjC domain-containing histone demethylase 2",
                    "type": "synonym"
                },
                {
                    "name": "Kdm3-PB",
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                {
                    "name": "lysine demethylase 3, isoform B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Kdm3",
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                    "name": "CG31123",
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                },
                {
                    "name": "CG8165",
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                {
                    "name": "Dmel\\CG8165",
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                {
                    "name": "JHDM2",
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                },
                {
                    "name": "KDM3",
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                },
                {
                    "name": "Kdm3",
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                },
                {
                    "name": "kdm3",
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            ],
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                {
                    "id": "0050634",
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            ]
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            "uniprot_canonical_ac": "P09622-1",
            "uniprot_ac": "P09622",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Dihydrolipoyl dehydrogenase, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.8.1.4",
                    "type": "synonym"
                },
                {
                    "name": "Dihydrolipoamide dehydrogenase",
                    "type": "synonym"
                },
                {
                    "name": "E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex",
                    "type": "synonym"
                },
                {
                    "name": "Glycine cleavage system L protein",
                    "type": "synonym"
                },
                {
                    "name": "diaphorase",
                    "type": "synonym"
                },
                {
                    "name": "dihydrolipoyl dehydrogenase, mitochondrial isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "dihydrolipoyl dehydrogenase, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "glycine cleavage system L protein",
                    "type": "synonym"
                },
                {
                    "name": "glycine cleavage system protein L",
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                },
                {
                    "name": "lipoamide dehydrogenase",
                    "type": "synonym"
                },
                {
                    "name": "lipoamide reductase",
                    "type": "synonym"
                },
                {
                    "name": "lipoyl dehydrogenase",
                    "type": "synonym"
                },
                {
                    "name": "pyruvate dehydrogenase complex subunit E3, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex, glycine cleavage system protein L",
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                }
            ],
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                {
                    "name": "DLD",
                    "type": "recommended"
                },
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                    "name": "DLDD",
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                },
                {
                    "name": "DLDH",
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                {
                    "name": "DLD",
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                {
                    "name": "E3",
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                },
                {
                    "name": "GCSL",
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                {
                    "name": "LAD",
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                },
                {
                    "name": "OGDC-E3",
                    "type": "synonym"
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                {
                    "name": "PHE3",
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                    "id": "0050634",
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                }
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            "uniprot_canonical_ac": "P05112-1",
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                {
                    "name": "Homo sapiens",
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                    "glygen_name": "Human",
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                }
            ],
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                    "name": "Interleukin-4",
                    "type": "recommended"
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                    "name": "B cell growth factor 1",
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                {
                    "name": "B-cell stimulatory factor 1",
                    "type": "synonym"
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                    "name": "BSF-1",
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                {
                    "name": "B_cell stimulatory factor 1",
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                    "name": "Binetrakin",
                    "type": "synonym"
                },
                {
                    "name": "IL-4",
                    "type": "synonym"
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                {
                    "name": "Lymphocyte stimulatory factor 1",
                    "type": "synonym"
                },
                {
                    "name": "Pitrakinra",
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                },
                {
                    "name": "binetrakin",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte stimulatory factor 1",
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                {
                    "name": "pitrakinra",
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                }
            ],
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                    "name": "IL4",
                    "type": "recommended"
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                {
                    "name": "BCGF-1",
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                },
                {
                    "name": "BCGF1",
                    "type": "synonym"
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                    "name": "BSF-1",
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                {
                    "name": "BSF1",
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                },
                {
                    "name": "IL-4",
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                {
                    "name": "IL4",
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                {
                    "id": "0050634",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050634"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050634"
}