{
    "disease_id": "DOID:0081042",
    "recommended_name": {
        "id": "DOID:0081042",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0081042",
        "name": "T-cell prolymphocytic leukemia",
        "description": "A prolymphocytic leukemia that is characterized by the proliferation of small to medium sized prolymphocytes with a mature T-cell phenotype, involving the blood, bone marrow, lymph nodes, liver, spleen, and skin."
    },
    "synonyms": [
        {
            "id": "DOID:0081042",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0081042",
            "name": "Prolymphocytic leukemia, T-cell type",
            "description": ""
        },
        {
            "id": "DOID:0081042",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0081042",
            "name": "T Cell Prolymphocytic Leukemia",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0081042"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0081042",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0081042",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "B0V237-1",
            "uniprot_ac": "B0V237",
            "uniprot_id": "B0V237_DANRE",
            "refseq_ac": "XP_002663133",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "jak3",
                    "type": "recommended"
                },
                {
                    "name": "jak3",
                    "type": "synonym"
                }
            ],
            "record_id": "B0V237-1",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62137-1",
            "uniprot_ac": "Q62137",
            "uniprot_id": "JAK3_MOUSE",
            "refseq_ac": "NP_001177759",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase JAK3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "JAK-3",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Jak3",
                    "type": "recommended"
                },
                {
                    "name": "Jak3",
                    "type": "synonym"
                },
                {
                    "name": "fae",
                    "type": "synonym"
                },
                {
                    "name": "wil",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62137-1",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q63272-1",
            "uniprot_ac": "Q63272",
            "uniprot_id": "JAK3_RAT",
            "refseq_ac": "NP_036987",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase JAK3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "JAK-3",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3, protein-tyrosine kinase",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Jak3",
                    "type": "recommended"
                },
                {
                    "name": "Insl3",
                    "type": "synonym"
                },
                {
                    "name": "Jak3",
                    "type": "synonym"
                },
                {
                    "name": "RATJAK3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q63272-1",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q24592-1",
            "uniprot_ac": "Q24592",
            "uniprot_id": "JAK_DROME",
            "refseq_ac": "NP_511119",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase hopscotch",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "CG1594-PA",
                    "type": "synonym"
                },
                {
                    "name": "Hop",
                    "type": "synonym"
                },
                {
                    "name": "JAK kinase",
                    "type": "synonym"
                },
                {
                    "name": "Janus-family kinase",
                    "type": "synonym"
                },
                {
                    "name": "hop-PA",
                    "type": "synonym"
                },
                {
                    "name": "hopscotch",
                    "type": "synonym"
                },
                {
                    "name": "hopskotch",
                    "type": "synonym"
                },
                {
                    "name": "janus kinase",
                    "type": "synonym"
                },
                {
                    "name": "locus 18",
                    "type": "synonym"
                },
                {
                    "name": "tumorous",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "hop",
                    "type": "recommended"
                },
                {
                    "name": "4",
                    "type": "synonym"
                },
                {
                    "name": "CG1594",
                    "type": "synonym"
                },
                {
                    "name": "Dm JAK",
                    "type": "synonym"
                },
                {
                    "name": "DmHD-160",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG1594",
                    "type": "synonym"
                },
                {
                    "name": "HD-160",
                    "type": "synonym"
                },
                {
                    "name": "HOP",
                    "type": "synonym"
                },
                {
                    "name": "Hop1",
                    "type": "synonym"
                },
                {
                    "name": "Hop2",
                    "type": "synonym"
                },
                {
                    "name": "Hop",
                    "type": "synonym"
                },
                {
                    "name": "Hpo",
                    "type": "synonym"
                },
                {
                    "name": "JAK",
                    "type": "synonym"
                },
                {
                    "name": "Jak",
                    "type": "synonym"
                },
                {
                    "name": "L4",
                    "type": "synonym"
                },
                {
                    "name": "Tum-1",
                    "type": "synonym"
                },
                {
                    "name": "Tum",
                    "type": "synonym"
                },
                {
                    "name": "d-jak",
                    "type": "synonym"
                },
                {
                    "name": "hop/JAK",
                    "type": "synonym"
                },
                {
                    "name": "hop",
                    "type": "synonym"
                },
                {
                    "name": "jak",
                    "type": "synonym"
                },
                {
                    "name": "l(1)10Be",
                    "type": "synonym"
                },
                {
                    "name": "l(1)G18",
                    "type": "synonym"
                },
                {
                    "name": "l(1)L4",
                    "type": "synonym"
                },
                {
                    "name": "l(1)hop",
                    "type": "synonym"
                },
                {
                    "name": "msvl",
                    "type": "synonym"
                }
            ],
            "record_id": "Q24592-1",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9P2D7-4",
            "uniprot_ac": "Q9P2D7",
            "uniprot_id": "DYH1_HUMAN",
            "refseq_ac": "NP_056327",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Dynein axonemal heavy chain 1",
                    "type": "recommended"
                },
                {
                    "name": "Axonemal beta dynein heavy chain 1",
                    "type": "synonym"
                },
                {
                    "name": "Ciliary dynein heavy chain 1",
                    "type": "synonym"
                },
                {
                    "name": "HSRF-1",
                    "type": "synonym"
                },
                {
                    "name": "Heat shock regulated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "axonemal beta dynein heavy chain 1",
                    "type": "synonym"
                },
                {
                    "name": "ciliary dynein heavy chain 1",
                    "type": "synonym"
                },
                {
                    "name": "dynein axonemal heavy chain 1",
                    "type": "synonym"
                },
                {
                    "name": "dynein heavy chain 1, axonemal",
                    "type": "synonym"
                },
                {
                    "name": "dynein, axonemal, heavy polypeptide 1",
                    "type": "synonym"
                },
                {
                    "name": "hDHC7",
                    "type": "synonym"
                },
                {
                    "name": "heat shock regulated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "testicular tissue protein Li 60",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DNAH1",
                    "type": "recommended"
                },
                {
                    "name": "CILD37",
                    "type": "synonym"
                },
                {
                    "name": "DHC7",
                    "type": "synonym"
                },
                {
                    "name": "DNAH1",
                    "type": "synonym"
                },
                {
                    "name": "DNAHC1",
                    "type": "synonym"
                },
                {
                    "name": "HDHC7",
                    "type": "synonym"
                },
                {
                    "name": "HL-11",
                    "type": "synonym"
                },
                {
                    "name": "HL11",
                    "type": "synonym"
                },
                {
                    "name": "HSRF-1",
                    "type": "synonym"
                },
                {
                    "name": "KIAA1410",
                    "type": "synonym"
                },
                {
                    "name": "SPGF18",
                    "type": "synonym"
                },
                {
                    "name": "XLHSRF-1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9P2D7-4",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P52333-1",
            "uniprot_ac": "P52333",
            "uniprot_id": "JAK3_HUMAN",
            "refseq_ac": "NP_000206",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tyrosine-protein kinase JAK3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.10.2",
                    "type": "synonym"
                },
                {
                    "name": "JAK-3",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3 (a protein tyrosine kinase, leukocyte)",
                    "type": "synonym"
                },
                {
                    "name": "Janus kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "L-JAK",
                    "type": "synonym"
                },
                {
                    "name": "Leukocyte janus kinase",
                    "type": "synonym"
                },
                {
                    "name": "leukocyte Janus kinase",
                    "type": "synonym"
                },
                {
                    "name": "tyrosine-protein kinase JAK3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "JAK3",
                    "type": "recommended"
                },
                {
                    "name": "JAK-3",
                    "type": "synonym"
                },
                {
                    "name": "JAK3_HUMAN",
                    "type": "synonym"
                },
                {
                    "name": "JAK3",
                    "type": "synonym"
                },
                {
                    "name": "JAKL",
                    "type": "synonym"
                },
                {
                    "name": "L-JAK",
                    "type": "synonym"
                },
                {
                    "name": "LJAK",
                    "type": "synonym"
                }
            ],
            "record_id": "P52333-1",
            "evidence": [
                {
                    "id": "0081042",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081042"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0081042"
}