{
    "biomarker_id": "AN6726-1",
    "biomarker_canonical_id": "AN6726",
    "condition": {
        "recommended_name": {
            "id": "DOID:1612",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1612",
            "name": "breast cancer",
            "description": "An organ system cancer that originates in the mammary gland."
        },
        "synonyms": [
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "breast tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant neoplasm of breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant tumor of the breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast carcinoma",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
    "biomarker_component": [
        {
            "biomarker": "increased EGFR level",
            "assessed_biomarker_entity_id": "P00533-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Epidermal growth factor receptor",
                "synonyms": [
                    {
                        "synonym": "Receptor tyrosine-protein kinase erbB-1"
                    },
                    {
                        "synonym": "Proto-oncogene c-ErbB-1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "breast",
                    "namespace": "UBERON",
                    "id": "0000310",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000310",
                    "loinc_code": "13659-8"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6726-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6726-1"
                },
                {
                    "id": "30431376",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/30431376",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The high expression of EGFR can be used to predict the severity of IBC, as well as the candidate biomarkers of metastasis, and it may also be associated with poor prognosis of IBC patients."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6726-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6726-1"
        },
        {
            "id": "30431376",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/30431376",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The high expression of EGFR can be used to predict the severity of IBC, as well as the candidate biomarkers of metastasis, and it may also be associated with poor prognosis of IBC patients."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6726-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6726-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Relationship of Epidermal Growth Factor Receptor Expression with Clinical Symptoms and Metastasis of Invasive Breast Cancer.",
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research",
            "authors": "Han L, Li L, Wang N, Xiong Y, Li Y, Gu Y",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30431376",
                    "url": "https://glygen.org/publication/PubMed/30431376"
                }
            ],
            "evidence": [
                {
                    "id": "AN6725-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6726-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}