{
    "biomarker_id": "AN6714-1",
    "biomarker_canonical_id": "AN6714",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased P4HB level",
            "assessed_biomarker_entity_id": "P07237-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Protein disulfide-isomerase",
                "synonyms": [
                    {
                        "synonym": "Prolyl 4-hydroxylase subunit beta"
                    },
                    {
                        "synonym": "p55"
                    },
                    {
                        "synonym": "Cellular thyroid hormone-binding protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6714-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6714-1"
                },
                {
                    "id": "31350524",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31350524",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "High expression of P4HB mRNA was related to significantly worse Overall Survival (OS) for KIRC patients (Kidney renal cell carcinoma) (p<0.0001). Univariate Cox regression analyses, showed higher stage and high P4HB mRNA expression exhibited unfavorable effects on OS (p<0.0001 and p<0.0001)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6714-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6714-1"
        },
        {
            "id": "31350524",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31350524",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "High expression of P4HB mRNA was related to significantly worse Overall Survival (OS) for KIRC patients (Kidney renal cell carcinoma) (p<0.0001). Univariate Cox regression analyses, showed higher stage and high P4HB mRNA expression exhibited unfavorable effects on OS (p<0.0001 and p<0.0001)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6714-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6714-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Computational identification and analysis of early diagnostic biomarkers for kidney cancer.",
            "journal": "Journal of human genetics",
            "authors": "Tang Tang, Du Xiaoyan, Zhang Xiaoyi, Niu Wenling, Li Chunhua, Tan Jianjun",
            "date": "2019-10",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31350524",
                    "url": "https://glygen.org/publication/PubMed/31350524"
                }
            ],
            "evidence": [
                {
                    "id": "AN6711-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6714-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}