{
    "biomarker_id": "AN6695-1",
    "biomarker_canonical_id": "AN6695",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased QKI level",
            "assessed_biomarker_entity_id": "Q96PU8-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "KH domain-containing RNA-binding protein QKI",
                "synonyms": [
                    {
                        "synonym": "Protein quaking"
                    },
                    {
                        "synonym": "Hqk"
                    },
                    {
                        "synonym": "HqkI"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6695-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6695-1"
                },
                {
                    "id": "27767378",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/27767378",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The relative expression level of QKI-5 was significantly lower in the tumor tissues than it was in their noncancerous counterparts (P < 0.01). Decreased QKI-5 expression significantly correlated with poorer overall survival in ccRCC patients."
                        }
                    ]
                },
                {
                    "id": "34804823",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/34804823",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Our results revealed that downregulation of QKI-5 by miR-200c attenuated KIRC migration and invasion via the EMT process, indicating that QKI-5 may be a potential therapeutic target and a key indicator of kidney renal clear cell carcinoma (KIRC) progression."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6695-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6695-1"
        },
        {
            "id": "27767378",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/27767378",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The relative expression level of QKI-5 was significantly lower in the tumor tissues than it was in their noncancerous counterparts (P < 0.01). Decreased QKI-5 expression significantly correlated with poorer overall survival in ccRCC patients."
                }
            ]
        },
        {
            "id": "34804823",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/34804823",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Our results revealed that downregulation of QKI-5 by miR-200c attenuated KIRC migration and invasion via the EMT process, indicating that QKI-5 may be a potential therapeutic target and a key indicator of kidney renal clear cell carcinoma (KIRC) progression."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6695-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6695-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA.",
            "journal": "Cell cycle (Georgetown, Tex.)",
            "authors": "Zhang RL, Yang JP, Peng LX, Zheng LS, Xie P, Wang MY, Cao Y, Zhang ZL, Zhou FJ, Qian CN, Bao YX",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27767378",
                    "url": "https://glygen.org/publication/PubMed/27767378"
                }
            ],
            "evidence": [
                {
                    "id": "AN6694-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6695-1"
                }
            ]
        },
        {
            "title": "Quaking I-5 protein inhibits invasion and migration of kidney renal clear cell carcinoma via inhibiting epithelial-mesenchymal transition suppression through the regulation of microRNA 200c.",
            "journal": "Translational andrology and urology",
            "authors": "Zhang R, Wang W, Aimudula A, Lu S, Lu P, Aihaiti R, Bao Y",
            "date": "2021",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34804823",
                    "url": "https://glygen.org/publication/PubMed/34804823"
                }
            ],
            "evidence": [
                {
                    "id": "AN6695-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6695-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}