{
    "biomarker_id": "AN6693-1",
    "biomarker_canonical_id": "AN6693",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased DKC1 level",
            "assessed_biomarker_entity_id": "O60832-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "H/ACA ribonucleoprotein complex subunit DKC1",
                "synonyms": [
                    {
                        "synonym": "Nucleolar protein family A member 4"
                    },
                    {
                        "synonym": "Nopp140-associated protein of 57 kDa"
                    },
                    {
                        "synonym": "Dyskerin"
                    },
                    {
                        "synonym": "Nucleolar protein NAP57"
                    },
                    {
                        "synonym": "CBF5 homolog"
                    },
                    {
                        "synonym": "snoRNP protein DKC1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6693-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6693-1"
                },
                {
                    "id": "29901172",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29901172",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "High DKC1 expression was detected in 61.3% ccRCC tissues and 34.7% paracancerous tissues. ccRCC patients with high DKC1 expression were correlated with greater unfavorable 5-year overall and disease-specific survival than the rest of the patients with low DKC1 expression (P<0.001 and P<0.001, respectively)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6693-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6693-1"
        },
        {
            "id": "29901172",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29901172",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "High DKC1 expression was detected in 61.3% ccRCC tissues and 34.7% paracancerous tissues. ccRCC patients with high DKC1 expression were correlated with greater unfavorable 5-year overall and disease-specific survival than the rest of the patients with low DKC1 expression (P<0.001 and P<0.001, respectively)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6693-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6693-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "DKC1 serves as a potential prognostic biomarker for human clear cell renal cell carcinoma and promotes its proliferation, migration and invasion via the NFkappaB pathway.",
            "journal": "Oncology reports",
            "authors": "Zhang M, Pan Y, Jiang R, Hou P, Shan H, Chen F, Jiang T, Bai J, Zheng J",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29901172",
                    "url": "https://glygen.org/publication/PubMed/29901172"
                }
            ],
            "evidence": [
                {
                    "id": "AN6692-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6693-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}