{
    "biomarker_id": "AN6692-1",
    "biomarker_canonical_id": "AN6692",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "increased NUPR1 level",
            "assessed_biomarker_entity_id": "O60356-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Nuclear protein 1",
                "synonyms": [
                    {
                        "synonym": "Candidate of metastasis 1"
                    },
                    {
                        "synonym": "Protein p8"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6692-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6692-1"
                },
                {
                    "id": "34030133",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/34030133",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "NUPR1 mRNA levels were significantly increased in ccRCC cells and cancer tissues compared with HK-2 cells (human renal cortex/proximal tubular epithelial cells) and adjacent normal kidney tissues. High NUPR1 mRNA level in primary tumors was correlated with poor overall survival (OS) and disease-free survival (DFS)."
                        }
                    ]
                },
                {
                    "id": "27451286",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/27451286",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Finally, immunohistochemical analysis revealed strong expression of NUPR1 in the nuclei of renal proximal tubules of injured human kidney allografts, but not in those of stable allografts. Taken together, these results suggest that epithelial expression of NUPR1 has a protective role in response to injury after renal transplant and, presumably, in other forms of acute tubular damage."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6692-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6692-1"
        },
        {
            "id": "34030133",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/34030133",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "NUPR1 mRNA levels were significantly increased in ccRCC cells and cancer tissues compared with HK-2 cells (human renal cortex/proximal tubular epithelial cells) and adjacent normal kidney tissues. High NUPR1 mRNA level in primary tumors was correlated with poor overall survival (OS) and disease-free survival (DFS)."
                }
            ]
        },
        {
            "id": "27451286",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/27451286",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Finally, immunohistochemical analysis revealed strong expression of NUPR1 in the nuclei of renal proximal tubules of injured human kidney allografts, but not in those of stable allografts. Taken together, these results suggest that epithelial expression of NUPR1 has a protective role in response to injury after renal transplant and, presumably, in other forms of acute tubular damage."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6692-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6692-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway.",
            "journal": "Aging",
            "authors": "He W, Cheng F, Zheng B, Wang J, Zhao G, Yao Z, Zhang T",
            "date": "2021",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34030133",
                    "url": "https://glygen.org/publication/PubMed/34030133"
                }
            ],
            "evidence": [
                {
                    "id": "AN6691-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6692-1"
                }
            ]
        },
        {
            "title": "Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo.",
            "journal": "Journal of the American Society of Nephrology : JASN",
            "authors": "Galichon P, Bataille A, Vandermeersch S, Wetzstein M, Xu-Dubois YC, Legouis D, Hertig A, Buob D, Placier S, Bige N, Lefevre G, Jouanneau C, Martin C, Iovanna JL, Rondeau E",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27451286",
                    "url": "https://glygen.org/publication/PubMed/27451286"
                }
            ],
            "evidence": [
                {
                    "id": "AN6692-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6692-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
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                    "count": 2
                }
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            "sort_fields": [
                "title",
                "journal",
                "authors",
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}