{
    "biomarker_id": "AN6645-1",
    "biomarker_canonical_id": "AN6645",
    "condition": {
        "recommended_name": {
            "id": "DOID:1781",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1781",
            "name": "thyroid cancer",
            "description": "An endocrine gland cancer located in the thyroid gland located in the neck below the thyroid cartilage."
        },
        "synonyms": [
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "Thyroid gland neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "malignant tumour of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "neoplasm of thyroid gland",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1781",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1781",
                "name": "thyroid gland cancer",
                "description": ""
            }
        ],
        "id": "DOID:1781"
    },
    "biomarker_component": [
        {
            "biomarker": "increased STAT3 level",
            "assessed_biomarker_entity_id": "P40763-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Signal transducer and activator of transcription 3",
                "synonyms": [
                    {
                        "synonym": "Acute-phase response factor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "thyroid gland",
                    "namespace": "UBERON",
                    "id": "0002046",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002046",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6645-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6645-1"
                },
                {
                    "id": "21577321",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21577321",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Expression of STAT3 in all PTC primary tumors was 98% (40/41) and thus significantly higher than corresponding benign thyroid tissue."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6645-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6645-1"
        },
        {
            "id": "21577321",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21577321",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Expression of STAT3 in all PTC primary tumors was 98% (40/41) and thus significantly higher than corresponding benign thyroid tissue."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6645-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6645-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Upregulation of the signal transducers and activators of transcription 3 (STAT3) pathway in lymphatic metastases of papillary thyroid cancer.",
            "journal": "International journal of clinical and experimental pathology",
            "authors": "Zhang J, Gill A, Atmore B, Johns A, Delbridge L, Lai R, McMullen T",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21577321",
                    "url": "https://glygen.org/publication/PubMed/21577321"
                }
            ],
            "evidence": [
                {
                    "id": "AN6644-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6645-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "journal",
                "authors",
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        }
    ]
}