{
    "biomarker_id": "AN6627-2",
    "biomarker_canonical_id": "AN6627",
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                "description": ""
            },
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                "description": ""
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                "description": ""
            },
            {
                "id": "MONDO:0001056",
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            },
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                "id": "MONDO:0001056",
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            },
            {
                "id": "MONDO:0001056",
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                "name": "malignant gastric tumour",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
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                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
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                "description": ""
            },
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                "id": "MONDO:0001056",
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                "id": "MONDO:0001056",
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                "id": "MONDO:0001056",
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            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of body of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of greater curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of lesser curve of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant tumor of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
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                "description": ""
            },
            {
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                "name": "malignant tumour of body of stomach",
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            },
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                "id": "MONDO:0001056",
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                "name": "malignant tumour of stomach",
                "description": ""
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                "name": "malignant tumour of the stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "stomach cancer",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "Ca body - stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "ca greater curvature of stomach",
                "description": ""
            },
            {
                "id": "MONDO:0001056",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                "name": "malignant neoplasm of body of stomach",
                "description": ""
            },
            {
                "id": "MIM:613659",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/613659",
                "name": "Gastric cancer",
                "description": "Gastric cancer"
            }
        ],
        "id": "DOID:10534"
    },
    "biomarker_component": [
        {
            "biomarker": "increased REG4 level",
            "assessed_biomarker_entity_id": "Q9BYZ8-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Regenerating islet-derived protein 4",
                "synonyms": [
                    {
                        "synonym": "Regenerating islet-derived protein IV"
                    },
                    {
                        "synonym": "Reg IV"
                    },
                    {
                        "synonym": "Gastrointestinal secretory protein"
                    },
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                        "synonym": "REG-like protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "stomach",
                    "namespace": "UBERON",
                    "id": "0000945",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000945",
                    "loinc_code": ""
                }
            ],
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                    "database": "BiomarkerKB",
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                },
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                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "In the present study, we show that high expression of REG4 correlates with advanced stage and poor survival prognosis for gastric cancer patients. REG4 overexpression significantly enhances peritoneal metastasis by increasing adhesion ability. Moreover, SP1 is proved to be a transcription factor of REG4 and induce REG4 expression upon TGF-alpha stimulation."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6627-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6627-2"
        },
        {
            "id": "27036049",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/27036049",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "In the present study, we show that high expression of REG4 correlates with advanced stage and poor survival prognosis for gastric cancer patients. REG4 overexpression significantly enhances peritoneal metastasis by increasing adhesion ability. Moreover, SP1 is proved to be a transcription factor of REG4 and induce REG4 expression upon TGF-alpha stimulation."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6627-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6627-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "REG4 promotes peritoneal metastasis of gastric cancer through GPR37.",
            "journal": "Oncotarget",
            "authors": "Wang H, Hu L, Zang M, Zhang B, Duan Y, Fan Z, Li J, Su L, Yan M, Zhu Z, Liu B, Yang Q",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27036049",
                    "url": "https://glygen.org/publication/PubMed/27036049"
                }
            ],
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                {
                    "id": "AN6627-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6627-2"
                }
            ]
        }
    ],
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            ],
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}