{ "biomarker_id": "AN6400-1", "biomarker_canonical_id": "AN6400", "condition": { "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "COVID-19", "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2." }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV infection", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "coronavirus disease 2019", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2 infectious disease", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019 novel coronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "2019-nCoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-CoV-2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "SARS-coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "beta-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "betacoronavirus", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "severe acute respiratory syndrome coronavirus 2", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoV", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-CoVs", "description": "" }, { "id": "MONDO:0100096", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100096", "name": "-coronavirus", "description": "" } ], "id": "DOID:0080600" }, "biomarker_component": [ { "biomarker": "increased NT-proBNP level", "assessed_biomarker_entity_id": "P01160-1", "assessed_entity_type": "protein", "assessed_biomarker_entity": { "recommended_name": "Natriuretic peptides A", "synonyms": [ { "synonym": "Cardiodilatin" }, { "synonym": "CDD" }, { "synonym": "CDD-ANF" }, { "synonym": "Pro atrial natriuretic factor 1-30" }, { "synonym": "proANF 1-30" }, { "synonym": "Atrial natriuretic factor" }, { "synonym": "ANF" }, { "synonym": "Atrial natriuretic factor 1-33" }, { "synonym": "ANF 1-33" }, { "synonym": "Pro atrial natriuretic peptide 95-126" }, { "synonym": "proANP 95-126" }, { "synonym": "Pro atrial natriuretic factor 99-126" }, { "synonym": "proANF 99-126" }, { "synonym": "Pro atrial natriuretic peptide 79-98" }, { "synonym": "proANP 79-98" }, { "synonym": "Pro atrial natriuretic peptide 1-30" }, { "synonym": "proANP 1-30" }, { "synonym": "Long-acting natriuretic hormone" }, { "synonym": "LANH" }, { "synonym": "Atrial natriuretic factor 3-33" }, { "synonym": "ANF 3-33" }, { "synonym": "Pro atrial natriuretic factor 79-98" }, { "synonym": "proANF 79-98" }, { "synonym": "Pro atrial natriuretic peptide 31-67" }, { "synonym": "proANP 31-67" }, { "synonym": "Atrial natriuretic factor 8-33" }, { "synonym": "ANF 8-33" }, { "synonym": "Pro atrial natriuretic factor 31-67" }, { "synonym": "proANF 31-67" }, { "synonym": "CDD 95-126" }, { "synonym": "Cardionatrin" }, { "synonym": "Atriopeptin III" }, { "synonym": "CDD-ANP (99-126)" }, { "synonym": "Alpha-atrial natriuretic peptide" }, { "synonym": "Atriopeptin I" }, { "synonym": "CDD-ANP (95-126)" }, { "synonym": "Atriopeptin II" }, { "synonym": "Alpha-hANP" }, { "synonym": "Atrial natriuretic peptide prohormone" }, { "synonym": "preproANP" }, { "synonym": "proANP" }, { "synonym": "Atrial natriuretic factor prohormone" }, { "synonym": "proANF" }, { "synonym": "preproCDD-ANF" }, { "synonym": "Atriopeptigen" } ] }, "specimen": [ { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "loinc_code": "20569-0" } ], "evidence_source": [ { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" }, { "id": "32596365", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32596365", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "The levels of laboratory cardiac markers, lactose dehydrogenase (LDH), creatine kinase (CK), creatinine kinase-muscle/brain activity (CK-MB), myoglobin (Mb), cardiac troponin I (cTnI), alpha-hydroxybutyrate dehydrogenase (\u03b1-HBDH), aspartate aminotransferase (AST), and N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) increase in different proportions in patients with COVID-19 (see Table 1)." } ] } ] }, { "biomarker": "increased NT-proBNP level", "assessed_biomarker_entity_id": "P16860-1", "assessed_entity_type": "protein", "assessed_biomarker_entity": { "recommended_name": "Natriuretic peptides B", "synonyms": [ { "synonym": "Gamma-brain natriuretic peptide" }, { "synonym": "Brain natriuretic peptide" }, { "synonym": "BNP" }, { "synonym": "NT-pro-BNP" }, { "synonym": "proBNP(79-108)" }, { "synonym": "des-SerPro-BNP" }, { "synonym": "NT-proBNP(1-76)" }, { "synonym": "Brain natriuretic factor prohormone" }, { "synonym": "preproBNP" }, { "synonym": "proBNP" }, { "synonym": "Iso-ANP" } ] }, "specimen": [ { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178", "loinc_code": "2639-3" } ], "evidence_source": [ { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" }, { "id": "32305557", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32305557", "tags": [ "assessed_biomarker_entity", " biomarker", " specimen" ], "evidence_list": [ { "evidence": "More severe COVID-19 infection is associated with higher mean troponin (SMD 0.53, 95% CI 0.30 to 0.75, p < 0.001), with a similar trend for creatine kinase-MB, myoglobin, and NT-proBNP. hsTnI and NT-proBNP levels increased during the course of hospitalization only in non-survivors." } ] } ] } ], "best_biomarker_role": [ { "role": "monitoring" } ], "evidence_source": [ { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" }, { "id": "32596365", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32596365", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "The levels of laboratory cardiac markers, lactose dehydrogenase (LDH), creatine kinase (CK), creatinine kinase-muscle/brain activity (CK-MB), myoglobin (Mb), cardiac troponin I (cTnI), alpha-hydroxybutyrate dehydrogenase (\u03b1-HBDH), aspartate aminotransferase (AST), and N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) increase in different proportions in patients with COVID-19 (see Table 1)." } ] }, { "id": "32305557", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32305557", "tags": [ "best_biomarker_role", " condition" ], "evidence_list": [ { "evidence": "More severe COVID-19 infection is associated with higher mean troponin (SMD 0.53, 95% CI 0.30 to 0.75, p < 0.001), with a similar trend for creatine kinase-MB, myoglobin, and NT-proBNP. hsTnI and NT-proBNP levels increased during the course of hospitalization only in non-survivors." } ] } ], "crossref": [ { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1", "categories": [ "Biomarkers" ] } ], "citation": [ { "title": "Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019.", "journal": "BioMed research international", "authors": "Li Lin, Zhou Qi, Xu Jiancheng", "date": "2020", "reference": [ { "type": "PubMed", "id": "32596365", "url": "https://glygen.org/publication/PubMed/32596365" } ], "evidence": [ { "id": "AN6755-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" }, { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" } ] }, { "title": "The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis.", "journal": "Progress in cardiovascular diseases", "authors": "Li JW, Han TW, Woodward M, Anderson CS, Zhou H, Chen YD, Neal B", "date": "2020", "reference": [ { "type": "PubMed", "id": "32305557", "url": "https://glygen.org/publication/PubMed/32305557" } ], "evidence": [ { "id": "AN6400-1", "database": "BiomarkerKB", "url": "https://biomarkerkb.org/biomarker/AN6400-1" } ] } ], "section_stats": [ { "table_id": "biomarker_component", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "biomarker", "assessed_biomarker_entity_id", "assessed_entity_type", "assessed_biomarker_entity.recommended_name" ] }, { "table_id": "citation", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "authors", "date" ] } ] }